Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RPS6KA3	6197	broad.mit.edu	37	X	20195168	20195168	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:20195168C>T	ENST00000379565.3	-	11	1087	c.880G>A	c.(880-882)Gaa>Aaa	p.E294K	RPS6KA3_ENST00000544447.1_Missense_Mutation_p.E266K|RPS6KA3_ENST00000540702.1_Missense_Mutation_p.E266K|RPS6KA3_ENST00000379548.4_Missense_Mutation_p.E265K	NM_004586.2	NP_004577.1	P51812	KS6A3_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 3	294	Protein kinase 1.				axon guidance|central nervous system development|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|skeletal system development|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein serine/threonine kinase activity			breast(4)|central_nervous_system(4)|endometrium(3)|kidney(2)|large_intestine(5)|liver(14)|lung(7)|ovary(1)|stomach(1)	41						CTCTGCGCTTCAGGACTCAAA	0.299000													37	90					0	0	1	0	0
CCDC173	129881	broad.mit.edu	37	2	170502583	170502583	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:170502583C>T	ENST00000447353.1	-	9	1532	c.1427G>A	c.(1426-1428)aGa>aAa	p.R476K		NM_001085447.1	NP_001078916.1			coiled-coil domain containing 173																		AATTACCTCTCTGGCATAGTC	0.393000													74	116					0	0	1	0	0
ZFYVE9	9372	broad.mit.edu	37	1	52703213	52703213	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:52703213C>A	ENST00000287727.3	+	4	296	c.124C>A	c.(124-126)Ccc>Acc	p.P42T	ZFYVE9_ENST00000371591.1_Missense_Mutation_p.P42T|ZFYVE9_ENST00000357206.2_Missense_Mutation_p.P42T			O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9	42					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			breast(1)|central_nervous_system(4)|endometrium(3)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	53						GATTCTAGATCCCCCTTCTCA	0.383000													27	88					4.40665e-25	4.91157e-25	1	1	0
ZNF773	374928	broad.mit.edu	37	19	58018640	58018640	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:58018640G>T	ENST00000282292.4	+	4	1317	c.1177G>T	c.(1177-1179)Ggg>Tgg	p.G393W	ZNF773_ENST00000598770.1_Missense_Mutation_p.G392W|ZNF773_ENST00000599847.1_Intron|ZNF773_ENST00000593916.1_Intron	NM_198542.1	NP_940944.1	Q6PK81	ZN773_HUMAN	zinc finger protein 773	393					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	22		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0254)		CAATGAATGTGGGAGATTCTT	0.418000													19	185					8.00594e-06	8.37103e-06	1	1	0
CLEC14A	161198	broad.mit.edu	37	14	38723989	38723989	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr14:38723989C>G	ENST00000342213.2	-	1	1585	c.1239G>C	c.(1237-1239)ttG>ttC	p.L413F		NM_175060.2	NP_778230.1	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	413						integral to membrane	sugar binding			breast(1)|cervix(2)|endometrium(2)|large_intestine(7)|lung(9)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		CTGTCATGGTCAAGATCACCA	0.537000													6	21					0	0	1	0	0
FNDC3B	64778	broad.mit.edu	37	3	172062049	172062049	+	Splice_Site	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:172062049G>A	ENST00000336824.4	+	19	2349		c.e19+1		FNDC3B_ENST00000416957.1_Splice_Site|FNDC3B_ENST00000415807.2_Splice_Site	NM_001135095.1	NP_001128567.1	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B							endoplasmic reticulum|integral to membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(12)|lung(26)|ovary(3)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	69	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		TGATGGAGGGGTGAGTATAAG	0.512000													14	62					0	0	1	0	0
DDX39A	10212	broad.mit.edu	37	19	14520163	14520163	+	Silent	SNP	G	G	A	rs141070619	byFrequency	TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:14520163G>A	ENST00000242776.4	-	9	1172	c.1071C>T	c.(1069-1071)atC>atT	p.I357I		NM_005804.3	NP_005795.2	O00148	DX39A_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A	357	Helicase C-terminal.				mRNA export from nucleus|nuclear mRNA splicing, via spliceosome	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			NS(1)|endometrium(5)|kidney(1)|lung(2)|ovary(1)|pancreas(1)	11						AGTTAAAGACGATGTTGACTC	0.612000													15	45					0	0	1	0	0
DCSTAMP	81501	broad.mit.edu	37	8	105360810	105360810	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr8:105360810C>G	ENST00000297581.2	+	2	79	c.30C>G	c.(28-30)atC>atG	p.I10M	DCSTAMP_ENST00000517991.1_Missense_Mutation_p.I10M|DPYS_ENST00000521601.1_Intron	NM_030788.3	NP_110415.1	Q9H295	TM7S4_HUMAN	dendrocyte expressed seven transmembrane protein	10					osteoclast differentiation	cell surface|integral to membrane|plasma membrane											GCACTGATATCTTCCTAAGTC	0.448000													13	68					0	0	1	0	0
ESR2	2100	broad.mit.edu	37	14	64701857	64701857	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr14:64701857G>C	ENST00000557772.1	-	7	1236	c.1237C>G	c.(1237-1239)Ctg>Gtg	p.L413V	ESR2_ENST00000553796.1_Missense_Mutation_p.L413V|ESR2_ENST00000357782.2_Missense_Mutation_p.L413V|ESR2_ENST00000341099.4_Missense_Mutation_p.L413V|ESR2_ENST00000554572.1_Missense_Mutation_p.L413V|ESR2_ENST00000353772.3_Missense_Mutation_p.L413V|ESR2_ENST00000555278.1_Missense_Mutation_p.L413V|ESR2_ENST00000542956.1_Missense_Mutation_p.L413V|ESR2_ENST00000267525.6_Missense_Mutation_p.L322V|ESR2_ENST00000358599.5_Missense_Mutation_p.L413V|ESR2_ENST00000555483.1_5'UTR	NM_001214903.1	NP_001201832.1	Q92731	ESR2_HUMAN	estrogen receptor 2 (ER beta)	413	Steroid-binding.				cell-cell signaling|negative regulation of cell growth|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	mitochondrion|nucleoplasm	enzyme binding|estrogen receptor activity|receptor antagonist activity|sequence-specific DNA binding transcription factor activity|steroid binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	23				all cancers(60;0.00916)|OV - Ovarian serous cystadenocarcinoma(108;0.0111)|BRCA - Breast invasive adenocarcinoma(234;0.0437)	Bicalutamide(DB01128)|Estradiol(DB00783)|Estramustine(DB01196)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Trilostane(DB01108)	GCTGTGACCAGAGGGTACATA	0.557000													6	23					0	0	1	0	0
FGD6	55785	broad.mit.edu	37	12	95604759	95604759	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:95604759G>C	ENST00000343958.4	-	2	524	c.301C>G	c.(301-303)Cag>Gag	p.Q101E	FGD6_ENST00000546711.1_Missense_Mutation_p.Q101E|FGD6_ENST00000549499.1_Missense_Mutation_p.Q101E	NM_018351.3	NP_060821.3	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	101					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(14)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	56						TCATTGCTCTGATTGCCTTCA	0.398000													28	142					0	0	1	0	0
ZNF483	158399	broad.mit.edu	37	9	114304657	114304657	+	Missense_Mutation	SNP	C	C	T	rs149958964	byFrequency	TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr9:114304657C>T	ENST00000309235.5	+	6	1600	c.1442C>T	c.(1441-1443)tCg>tTg	p.S481L	ZNF483_ENST00000358151.4_Intron	NM_133464.2	NP_597721.2	Q8TF39	ZN483_HUMAN	zinc finger protein 483	481					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(11)|lung(11)|ovary(1)|skin(5)	31						GATAGTTCATCGCTCACACCA	0.418000													3	42					0	0	1	0	0
SLC17A7	57030	broad.mit.edu	37	19	49933880	49933880	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:49933880C>T	ENST00000221485.3	-	12	1750	c.1579G>A	c.(1579-1581)Gag>Aag	p.E527K	SLC17A7_ENST00000600601.1_Missense_Mutation_p.E460K|SLC17A7_ENST00000543531.1_Missense_Mutation_p.E515K	NM_020309.3	NP_064705.1	Q9P2U7	VGLU1_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 7	527					glutamate secretion|neurotransmitter secretion	cell junction|clathrin sculpted glutamate transport vesicle membrane|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|sodium-dependent phosphate transmembrane transporter activity|sodium:inorganic phosphate symporter activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(7)|ovary(2)|pancreas(1)|skin(1)|stomach(1)	26		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(486;0.0245)		GGCTCAGCCTCATCCTCCATT	0.667000													24	43					0	0	1	0	0
GPR63	81491	broad.mit.edu	37	6	97247334	97247334	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:97247334G>C	ENST00000229955.3	-	2	619	c.274C>G	c.(274-276)Ctg>Gtg	p.L92V	GPR63_ENST00000417980.1_Missense_Mutation_p.L92V	NM_001143957.2|NM_030784.3	NP_001137429.1|NP_110411.1	Q9BZJ6	GPR63_HUMAN	G protein-coupled receptor 63	92						integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			kidney(1)|large_intestine(5)|lung(13)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		all_cancers(76;6.89e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0618)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0912)		GACACAAACAGAATGAATATC	0.438000													6	43					0	0	1	0	0
RUSC1	23623	broad.mit.edu	37	1	155291799	155291799	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:155291799C>T	ENST00000368352.5	+	2	386	c.235C>T	c.(235-237)Ccg>Tcg	p.P79S	RUSC1-AS1_ENST00000450199.1_RNA|RUSC1-AS1_ENST00000443642.1_RNA|RUSC1_ENST00000368354.3_Missense_Mutation_p.P79S	NM_001105203.1	NP_001098673.1	Q9BVN2	RUSC1_HUMAN	RUN and SH3 domain containing 1	79						cytoplasm|nucleolus	SH3/SH2 adaptor activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(2)|liver(2)|lung(7)|ovary(2)|skin(1)|urinary_tract(1)	21	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;1.55e-10)|all cancers(21;4.15e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)			GGAGCACGGTCCGGGCCTAGA	0.667000													10	14					0	0	1	0	0
ZC3HAV1	56829	broad.mit.edu	37	7	138768692	138768692	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:138768692G>A	ENST00000242351.5	-	3	847	c.531C>T	c.(529-531)ttC>ttT	p.F177F	ZC3HAV1_ENST00000464606.1_Silent_p.F177F|ZC3HAV1_ENST00000471652.1_Silent_p.F177F	NM_020119.3	NP_064504.2	Q7Z2W4	ZCCHV_HUMAN	zinc finger CCCH-type, antiviral 1	177					response to virus	cytoplasm|nucleus	NAD+ ADP-ribosyltransferase activity|RNA binding|zinc ion binding			cervix(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|prostate(4)|skin(1)	37						TCCCTCGGGTGAAGTGGTCAC	0.542000													8	37					0	0	1	0	0
USP3	9960	broad.mit.edu	37	15	63882911	63882911	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr15:63882911C>G	ENST00000268049.7	+	16	1707	c.1383C>G	c.(1381-1383)ttC>ttG	p.F461L	USP3-AS1_ENST00000560962.1_RNA|USP3_ENST00000559711.1_Missense_Mutation_p.F394L|USP3-AS1_ENST00000558831.1_RNA|USP3_ENST00000540797.1_Missense_Mutation_p.F439L|USP3-AS1_ENST00000559737.1_RNA|USP3_ENST00000380324.3_Missense_Mutation_p.F483L|USP3_ENST00000558285.1_Missense_Mutation_p.F466L|USP3_ENST00000539772.1_Missense_Mutation_p.F234L|USP3-AS1_ENST00000559861.1_RNA|USP3-AS1_ENST00000561256.1_RNA|USP3_ENST00000558218.1_3'UTR			Q9Y6I4	UBP3_HUMAN	ubiquitin specific peptidase 3	483					DNA repair|histone deubiquitination|mitotic cell cycle|regulation of protein stability|ubiquitin-dependent protein catabolic process	nuclear chromatin	histone binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			endometrium(3)|large_intestine(7)|lung(4)	14				GBM - Glioblastoma multiforme(80;0.0187)		GCCGCTGGTTCCACTTCAATG	0.473000													5	101					0	0	1	0	0
OR6N1	128372	broad.mit.edu	37	1	158736082	158736082	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:158736082G>A	ENST00000335094.2	-	1	410	c.391C>T	c.(391-393)Cac>Tac	p.H131Y		NM_001005185.1	NP_001005185.1	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N, member 1	131					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54	all_hematologic(112;0.0378)					GTTGGGTAGTGGAGGGGCCGG	0.512000													6	34					0	0	1	0	0
CXCL9	4283	broad.mit.edu	37	4	76926031	76926031	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr4:76926031A>T	ENST00000264888.5	-	3	245	c.207T>A	c.(205-207)aaT>aaA	p.N69K	RP11-630D6.5_ENST00000501239.2_RNA	NM_002416.1	NP_002407.1	Q07325	CXCL9_HUMAN	chemokine (C-X-C motif) ligand 9	69					cell-cell signaling|cellular defense response|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response	extracellular space	chemokine activity			large_intestine(3)|liver(1)|lung(5)|ovary(1)|skin(1)	11			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TTTGAACTCCATTCTTCAGTG	0.323000													9	46					0	0	1	0	0
PNLDC1	154197	broad.mit.edu	37	6	160222187	160222187	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:160222187G>C	ENST00000610273.1	+	3	315	c.144G>C	c.(142-144)caG>caC	p.Q48H	PNLDC1_ENST00000392167.3_Missense_Mutation_p.Q59H|PNLDC1_ENST00000609334.1_3'UTR	NM_001271862.1|NM_173516.1	NP_001258791.1|NP_775787.1	Q8NA58	PNDC1_HUMAN	poly(A)-specific ribonuclease (PARN)-like domain containing 1							integral to membrane|nucleus	nucleic acid binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(9)|ovary(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	31		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;1.55e-18)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		AGACCCGTCAGAGTGTTCAGC	0.413000													25	155					0	0	1	0	0
OR51D1	390038	broad.mit.edu	37	11	4661542	4661542	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:4661542C>T	ENST00000357605.2	+	1	598	c.522C>T	c.(520-522)ttC>ttT	p.F174F		NM_001004751.2	NP_001004751.1	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D, member 1	174					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|liver(2)|lung(14)|prostate(1)|skin(2)|urinary_tract(1)	27		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)		CACTGCCCTTCATCCTCAAGT	0.507000													18	57					0	0	1	0	0
TRMT2B	79979	broad.mit.edu	37	X	100296327	100296327	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:100296327C>T	ENST00000338687.7	-	4	1087	c.282G>A	c.(280-282)ttG>ttA	p.L94L	TRMT2B_ENST00000545398.1_Silent_p.L94L|TRMT2B_ENST00000372939.1_Silent_p.L94L|TRMT2B_ENST00000478422.1_5'UTR|TRMT2B_ENST00000372931.5_Silent_p.L94L|TRMT2B_ENST00000372935.1_Silent_p.L94L|TRMT2B_ENST00000372936.3_Silent_p.L94L			Q96GJ1	TRM2_HUMAN	tRNA methyltransferase 2 homolog B (S. cerevisiae)	94							tRNA (uracil-5-)-methyltransferase activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	24						CTTCATAGCTCAACCTCCAGA	0.433000													17	35					0	0	1	0	0
KCNC4	3749	broad.mit.edu	37	1	110765807	110765807	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:110765807C>G	ENST00000369787.3	+	2	927	c.900C>G	c.(898-900)atC>atG	p.I300M	KCNC4_ENST00000412512.2_Intron|KCNC4_ENST00000413138.3_Missense_Mutation_p.I300M|KCNC4_ENST00000438661.2_Missense_Mutation_p.I300M	NM_004978.4	NP_004969.2	Q03721	KCNC4_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 4	300					synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(2)|lung(11)|ovary(1)|skin(2)	32		all_cancers(81;9.88e-06)|all_epithelial(167;3.23e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0238)|all cancers(265;0.0693)|Epithelial(280;0.0748)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.135)		TGGTGCGCATCGTGTGCTGCC	0.607000													6	89					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10933880	10933880	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr21:10933880G>A	ENST00000298232.7	-	16	1312	c.945C>T	c.(943-945)atC>atT	p.I315I	TPTE_ENST00000361285.4_Silent_p.I333I|TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000342420.5_Silent_p.I295I	NM_199259.2	NP_954868	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	333	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.I333I(1)|p.I315I(1)		NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GAATCGCTACGATGTTTTCAA	0.313000													23	89					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9089781	9089781	+	Silent	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:9089781G>C	ENST00000397910.4	-	1	2237	c.2034C>G	c.(2032-2034)gtC>gtG	p.V678V		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	678	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCTCAGGGATGACAGAAGAAA	0.522000													31	46					0	0	1	0	0
CKB	1152	broad.mit.edu	37	14	103988660	103988660	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr14:103988660G>A	ENST00000348956.2	-	2	528	c.171C>T	c.(169-171)atC>atT	p.I57I		NM_001823.4	NP_001814.2	P12277	KCRB_HUMAN	creatine kinase, brain	57	Phosphagen kinase N-terminal.				creatine metabolic process	cytosol	ATP binding|creatine kinase activity			lung(2)|prostate(1)	3		Melanoma(154;0.155)	Epithelial(46;0.14)		Creatine(DB00148)	CGCCTGTCTGGATGACGTCGT	0.736000													6	9					0	0	1	0	0
LECT2	3950	broad.mit.edu	37	5	135290515	135290515	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr5:135290515G>C	ENST00000274507.1	-	1	208	c.8C>G	c.(7-9)tCc>tGc	p.S3C	LECT2_ENST00000522943.1_Missense_Mutation_p.S3C|LECT2_ENST00000514447.2_Missense_Mutation_p.S3C	NM_002302.2	NP_002293.2	O14960	LECT2_HUMAN	leukocyte cell-derived chemotaxin 2	3					chemotaxis|skeletal system development	cytoplasm|extracellular space				large_intestine(1)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GGCTTTGGTGGAAAACATCTG	0.373000													8	40					0	0	1	0	0
EPHA5	2044	broad.mit.edu	37	4	66201676	66201676	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr4:66201676C>T	ENST00000273854.3	-	16	3426	c.2826G>A	c.(2824-2826)ctG>ctA	p.L942L	EPHA5_ENST00000354839.4_Silent_p.L920L|EPHA5_ENST00000511294.1_Silent_p.L943L|EPHA5_ENST00000432638.2_Silent_p.L779L	NM_001281765.1|NM_004439.5	NP_001268694.1|NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	942					cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						CCAGCGTCTTCAGACTACTTG	0.413000										TSP Lung(17;0.13)			11	82					0	0	1	0	0
BPIFA3	128861	broad.mit.edu	37	20	31814242	31814242	+	Silent	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr20:31814242C>G	ENST00000375454.3	+	5	777	c.567C>G	c.(565-567)ctC>ctG	p.L189L	BPIFA3_ENST00000490499.1_3'UTR|BPIFA3_ENST00000375452.3_Silent_p.L153L	NM_178466.3	NP_848561.2	Q9BQP9	SPLC3_HUMAN	BPI fold containing family A, member 3	189						extracellular region	lipid binding										ATCAGTTTCTCTACAACCTCA	0.423000													39	86					0	0	1	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90161914	90161914	+	RNA	SNP	T	T	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr16:90161914T>C	ENST00000567960.1	+	0	650				TUBB8P7_ENST00000564451.1_RNA																							ACCCTAAAACTGCCCACACCC	0.527000													6	22					0	0	1	0	0
NPEPPS	9520	broad.mit.edu	37	17	45669349	45669349	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr17:45669349G>C	ENST00000322157.4	+	11	1525	c.1288G>C	c.(1288-1290)Gat>Cat	p.D430H	NPEPPS_ENST00000544660.1_Missense_Mutation_p.D350H|NPEPPS_ENST00000530173.1_Missense_Mutation_p.D426H|NPEPPS_ENST00000525037.1_3'UTR	NM_006310.3	NP_006301.3	P55786	PSA_HUMAN	aminopeptidase puromycin sensitive	430					proteolysis	cytosol|nucleus	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(6)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	27						ATCTGAGGTTGATGAGATATT	0.388000													4	35					0	0	1	0	0
ATAD3B	83858	broad.mit.edu	37	1	1418033	1418033	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:1418033G>C	ENST00000378741.3	+	7	911	c.285G>C	c.(283-285)gaG>gaC	p.E95D	ATAD3B_ENST00000308647.7_Intron|ATAD3B_ENST00000378736.3_3'UTR			Q5T9A4	ATD3B_HUMAN	ATPase family, AAA domain containing 3B	0							ATP binding|nucleoside-triphosphatase activity			endometrium(2)|large_intestine(1)|lung(3)|ovary(1)|skin(2)|urinary_tract(1)	10	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		AGGTGGCTGAGAGGCAGCATG	0.587000													4	80					0	0	1	0	0
KAT6B	23522	broad.mit.edu	37	10	76735876	76735876	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr10:76735876G>C	ENST00000287239.4	+	8	2270	c.1781G>C	c.(1780-1782)aGa>aCa	p.R594T	KAT6B_ENST00000372711.1_Intron|KAT6B_ENST00000372714.1_Intron|KAT6B_ENST00000372724.1_Intron|KAT6B_ENST00000372725.1_Intron	NM_001256468.1|NM_012330.3	NP_001243397.1|NP_036462.2	Q8WYB5	MYST4_HUMAN	K(lysine) acetyltransferase 6B	594	Negatively regulates HAT activity.				histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding										AGAGATATTAGAAGTCGGTTT	0.428000													15	44					0	0	1	0	0
U2AF1	7307	broad.mit.edu	37	21	44514877	44514877	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr21:44514877C>T	ENST00000459639.1	-	5	1175	c.151G>A	c.(151-153)Gaa>Aaa	p.E51K	U2AF1_ENST00000398137.1_Missense_Mutation_p.E51K|U2AF1_ENST00000486519.1_5'UTR|U2AF1_ENST00000380276.2_Missense_Mutation_p.E124K|U2AF1_ENST00000291552.4_Missense_Mutation_p.E124K			Q01081	U2AF1_HUMAN	U2 small nuclear RNA auxiliary factor 1	124					mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	Cajal body|catalytic step 2 spliceosome|nuclear speck	nucleotide binding|RNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(111)|large_intestine(2)|lung(7)|prostate(2)|skin(1)	126						ACAGCCTTTTCCGCATCTTCC	0.473000			Mis		"""CLL, MDS"""								6	34					0	0	1	0	0
KAT6A	7994	broad.mit.edu	37	8	41800466	41800466	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr8:41800466G>A	ENST00000396930.3	-	15	2824	c.2281C>T	c.(2281-2283)Cag>Tag	p.Q761*	KAT6A_ENST00000406337.1_Nonsense_Mutation_p.Q761*|KAT6A_ENST00000265713.2_Nonsense_Mutation_p.Q761*|KAT6A_ENST00000485568.1_Nonsense_Mutation_p.Q761*	NM_001099412.1	NP_001092882.1	Q92794	MYST3_HUMAN	K(lysine) acetyltransferase 6A	761	Catalytic.|Mediates interaction with BRPF1, required for histone H3 acetyltransferase activity.				histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding										AAATTCAGCTGAAGCTTTGCC	0.453000													6	127					0	0	1	0	0
NRBP2	340371	broad.mit.edu	37	8	144919309	144919309	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr8:144919309G>A	ENST00000442628.2	-	14	1304	c.1165C>T	c.(1165-1167)Cga>Tga	p.R389*	NRBP2_ENST00000327830.5_Nonsense_Mutation_p.R146*	NM_178564.3	NP_848659.2	Q9NSY0	NRBP2_HUMAN	nuclear receptor binding protein 2	389					negative regulation of neuron apoptosis|neuron differentiation	cytoplasm	ATP binding|protein kinase activity			central_nervous_system(2)|kidney(1)|large_intestine(2)	5	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			CCCAGGGGTCGAGTGGCTGCA	0.627000													17	21					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144865880	144865880	+	Silent	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:144865880G>C	ENST00000369359.4	-	38	6146	c.6108C>G	c.(6106-6108)ctC>ctG	p.L2036L	PDE4DIP_ENST00000530740.1_Silent_p.L1985L|PDE4DIP_ENST00000369354.3_Silent_p.L1900L|PDE4DIP_ENST00000369356.4_Silent_p.L1900L|PDE4DIP_ENST00000313382.9_Silent_p.L1794L|PDE4DIP_ENST00000524974.1_5'UTR			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	1900					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TCTCATTGCAGAGCTGAGGTA	0.468000			T	PDGFRB	MPD								121	406					0	0	1	0	0
MED12	9968	broad.mit.edu	37	X	70347966	70347966	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:70347966G>T	ENST00000333646.6	+	22	3404	c.3205G>T	c.(3205-3207)Gat>Tat	p.D1069Y	MED12_ENST00000374080.3_Missense_Mutation_p.D1069Y|MED12_ENST00000374102.1_Missense_Mutation_p.D1069Y	NM_005120.2	NP_005111.2	Q93074	MED12_HUMAN	mediator complex subunit 12	1069					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(6)|central_nervous_system(2)|endometrium(22)|kidney(5)|large_intestine(8)|lung(31)|ovary(2)|pancreas(1)|prostate(11)|skin(5)|soft_tissue(323)|upper_aerodigestive_tract(1)|urinary_tract(3)	420	Renal(35;0.156)					CCATGATCCCGATAGGTATGG	0.537000			"""M, S"""		uterine leiomyoma		Opitz-Kaveggia Syndrome						17	67					3.52763e-06	3.69653e-06	1	1	0
GLI2	2736	broad.mit.edu	37	2	121746705	121746705	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:121746705C>T	ENST00000452319.1	+	14	3275	c.3215C>T	c.(3214-3216)gCg>gTg	p.A1072V	GLI2_ENST00000361492.4_Missense_Mutation_p.A1072V|GLI2_ENST00000314490.11_Missense_Mutation_p.A744V			P10070	GLI2_HUMAN	GLI family zinc finger 2	1072					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				TACATCAAGGCGCACGCCAGT	0.697000													10	45					0	0	1	0	0
ADCY5	111	broad.mit.edu	37	3	123021988	123021988	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:123021988G>A	ENST00000462833.1	-	14	3850	c.2638C>T	c.(2638-2640)Cac>Tac	p.H880Y	ADCY5_ENST00000309879.5_Missense_Mutation_p.H530Y|ADCY5_ENST00000491190.1_Missense_Mutation_p.H513Y	NM_183357.2	NP_899200.1	O95622	ADCY5_HUMAN	adenylate cyclase 5	880					activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(22)|ovary(5)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(114;0.0342)		TCCGCCACGTGACACGCGTTG	0.642000													10	25					0	0	1	0	0
PTPRC	5788	broad.mit.edu	37	1	198682129	198682129	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:198682129C>G	ENST00000367376.2	+	12	1384	c.1213C>G	c.(1213-1215)Caa>Gaa	p.Q405E	PTPRC_ENST00000352140.3_Missense_Mutation_p.Q357E|PTPRC_ENST00000442510.2_Missense_Mutation_p.Q407E|PTPRC_ENST00000594404.1_Missense_Mutation_p.Q244E|PTPRC_ENST00000348564.6_Missense_Mutation_p.Q246E	NM_002838.4	NP_002829.3	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	405	Fibronectin type-III 1.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(7)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(22)|lung(41)|ovary(4)|pancreas(2)|prostate(1)|skin(13)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	111						AGCTGCACATCAAGGAGTAAT	0.318000													33	94					0	0	1	0	0
FRMD3	257019	broad.mit.edu	37	9	85913689	85913689	+	Silent	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr9:85913689G>T	ENST00000304195.3	-	12	1250	c.1044C>A	c.(1042-1044)atC>atA	p.I348I	FRMD3_ENST00000376438.1_Silent_p.I348I|FRMD3_ENST00000376434.1_Silent_p.I154I	NM_001244960.1|NM_174938.5	NP_001231889.1|NP_777598.3	A2A2Y4	FRMD3_HUMAN	FERM domain containing 3	348						cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|liver(1)|lung(15)|ovary(1)|upper_aerodigestive_tract(1)	30						GCTCCCTCTGGATCTTGGAAC	0.493000													5	28					0.217242	0.217694	1	1	0
S1PR5	53637	broad.mit.edu	37	19	10624718	10624718	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:10624718C>T	ENST00000439028.3	-	2	1095	c.970G>A	c.(970-972)Gga>Aga	p.G324R	S1PR5_ENST00000333430.4_Missense_Mutation_p.G324R	NM_001166215.1	NP_001159687.1	Q9H228	S1PR5_HUMAN	sphingosine-1-phosphate receptor 5	324						integral to membrane|plasma membrane	lysosphingolipid and lysophosphatidic acid receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	12						GAGTGGCGTCCGCAGCAGACC	0.701000													5	40					0	0	1	0	0
ZNF254	9534	broad.mit.edu	37	19	24310125	24310125	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:24310125A>C	ENST00000357002.4	+	4	1438	c.1323A>C	c.(1321-1323)aaA>aaC	p.K441N	ZNF254_ENST00000342944.6_Missense_Mutation_p.K356N	NM_001278661.1|NM_001278662.1|NM_001278664.1|NM_001278677.1|NM_001278678.1|NM_203282.2	NP_001265590.1|NP_001265591.1|NP_001265593.1|NP_001265606.1|NP_001265607.1|NP_975011.3	O75437	ZN254_HUMAN	zinc finger protein 254	441					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				AATGTGGCAAAGCATTTATCT	0.368000													9	40					0	0	1	0	0
PRSS35	167681	broad.mit.edu	37	6	84233890	84233890	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:84233890G>A	ENST00000536636.1	+	3	1075	c.730G>A	c.(730-732)Gaa>Aaa	p.E244K	PRSS35_ENST00000369700.3_Missense_Mutation_p.E244K	NM_001170423.1	NP_001163894.1	Q8N3Z0	PRS35_HUMAN	protease, serine, 35	244	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|endometrium(2)|large_intestine(12)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	32		all_cancers(76;0.000113)|Acute lymphoblastic leukemia(125;1.09e-08)|all_hematologic(105;3.12e-05)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0768)		GAGGATTGCCGAAGGGAGGCC	0.567000													4	23					0	0	1	0	0
ARMC4	55130	broad.mit.edu	37	10	28229527	28229527	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr10:28229527G>C	ENST00000305242.5	-	13	2043	c.1951C>G	c.(1951-1953)Cca>Gca	p.P651A	ARMC4_ENST00000537576.1_Missense_Mutation_p.P343A|ARMC4_ENST00000545014.1_Missense_Mutation_p.P176A	NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	651							binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						CCCACCACTGGAATTAGCATG	0.468000													23	33					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577058	7577058	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr17:7577058C>A	ENST00000420246.2	-	8	1012	c.880G>T	c.(880-882)Gag>Tag	p.E294*	TP53_ENST00000445888.2_Nonsense_Mutation_p.E294*|TP53_ENST00000359597.4_Nonsense_Mutation_p.E294*|TP53_ENST00000269305.4_Nonsense_Mutation_p.E294*|TP53_ENST00000413465.2_Intron|TP53_ENST00000455263.2_Nonsense_Mutation_p.E294*	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	294	Interaction with E4F1.|Interaction with HIPK1 (By similarity).		E -> A (in a sporadic cancer; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> Q (in sporadic cancers; somatic mutation).|E -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E294*(46)|p.E294fs*51(9)|p.K291fs*48(8)|p.0?(8)|p.E294K(3)|p.E294fs*12(3)|p.?(2)|p.E294Q(2)|p.L265_K305del41(1)|p.E294>*(1)|p.G293fs*1(1)|p.R290fs*50(1)|p.R290_P295>X(1)|p.E294fs*11(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGGTGAGGCTCCCCTTTCTTG	0.567000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			21	19					1.2644e-06	1.32638e-06	1	1	0
BUB3	9184	broad.mit.edu	37	10	124919978	124919978	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr10:124919978G>C	ENST00000368865.4	+	5	682	c.473G>C	c.(472-474)aGa>aCa	p.R158T	BUB3_ENST00000368858.5_Missense_Mutation_p.R158T|BUB3_ENST00000538238.1_Missense_Mutation_p.R78T|BUB3_ENST00000368859.2_Intron	NM_004725.3	NP_004716.1	O43684	BUB3_HUMAN	BUB3 mitotic checkpoint protein	158					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|attachment of spindle microtubules to kinetochore|cell division|meiosis|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	condensed chromosome kinetochore|cytosol|nucleus	protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)	9		all_neural(114;0.0765)|Colorectal(57;0.102)|all_lung(145;0.11)|Lung NSC(174;0.163)				GCAGGCCGCAGAGTGTTGGTG	0.498000													16	53					0	0	1	0	0
NXNL2	158046	broad.mit.edu	37	9	91150561	91150561	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr9:91150561C>G	ENST00000375855.3	+	1	542	c.212C>G	c.(211-213)tCa>tGa	p.S71*	NXNL2_ENST00000375854.3_Nonsense_Mutation_p.S71*|NXNL2_ENST00000487646.2_3'UTR	NM_145283.2	NP_660326.2	Q5VZ03	NXNL2_HUMAN	nucleoredoxin-like 2	71	Thioredoxin.									lung(3)	3						GTCTTCGTGTCAGCCGACGGC	0.701000													6	16					0	0	1	0	0
BST1	683	broad.mit.edu	37	4	15707257	15707257	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr4:15707257G>A	ENST00000382346.3	+	3	402	c.353G>A	c.(352-354)aGa>aAa	p.R118K	BST1_ENST00000265016.4_Missense_Mutation_p.R103K			Q10588	BST1_HUMAN	bone marrow stromal cell antigen 1	103					humoral immune response|multicellular organismal development	anchored to membrane|extrinsic to membrane|plasma membrane	binding|NAD+ nucleosidase activity			central_nervous_system(1)|large_intestine(1)|lung(2)|stomach(3)|urinary_tract(1)	8						TCTATTCCCAGAGATAAGGTA	0.488000													50	38					0	0	1	0	0
IGF2BP3	10643	broad.mit.edu	37	7	23381743	23381743	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:23381743C>T	ENST00000258729.3	-	10	1499	c.1143G>A	c.(1141-1143)ggG>ggA	p.G381G		NM_006547.2	NP_006538.2	O00425	IF2B3_HUMAN	insulin-like growth factor 2 mRNA binding protein 3	381					anatomical structure morphogenesis|negative regulation of translation|translation	cytosol|nucleus	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(14)|ovary(2)|prostate(2)|skin(4)|stomach(1)	34						GAGGTGGCATCCCTGAAGTGG	0.493000													4	23					0	0	1	0	0
FTO	79068	broad.mit.edu	37	16	53860020	53860020	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr16:53860020C>T	ENST00000471389.1	+	3	590	c.368C>T	c.(367-369)tCt>tTt	p.S123F	FTO_ENST00000394647.3_Intron	NM_001080432.2	NP_001073901.1	Q9C0B1	FTO_HUMAN	fat mass and obesity associated	123	Fe2OG dioxygenase domain.				DNA dealkylation involved in DNA repair|oxidative single-stranded DNA demethylation|oxidative single-stranded RNA demethylation|RNA repair	nucleus	DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|oxidative DNA demethylase activity|oxidative RNA demethylase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(1)|kidney(2)|large_intestine(7)|lung(13)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	29						GTGAAAGGGTCTAATATAAAA	0.502000													11	18					0	0	1	0	0
PPRC1	23082	broad.mit.edu	37	10	103899030	103899030	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr10:103899030C>T	ENST00000278070.2	+	5	804	c.765C>T	c.(763-765)ttC>ttT	p.F255F	PPRC1_ENST00000413464.2_Silent_p.F255F	NM_015062.3	NP_055877.3	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator-related 1	255					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(10)|lung(19)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		TGGCCAGCTTCAGTGGCCAGA	0.582000													14	35					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62290314	62290314	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:62290314G>T	ENST00000378024.4	-	5	11849	c.11575C>A	c.(11575-11577)Ccc>Acc	p.P3859T	AHNAK_ENST00000530124.1_Intron|AHNAK_ENST00000257247.7_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	3859					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				TTGAATTTGGGACCTTTCAAC	0.478000													42	184					6.68952e-21	7.39611e-21	1	1	0
SMURF1	57154	broad.mit.edu	37	7	98633248	98633248	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:98633248C>T	ENST00000361125.1	-	17	2298	c.1979G>A	c.(1978-1980)cGg>cAg	p.R660Q	SMURF1_ENST00000361368.2_Missense_Mutation_p.R634Q|AC004893.11_ENST00000468960.2_RNA|AC004893.11_ENST00000360902.1_RNA	NM_020429.2	NP_065162.1	Q9HCE7	SMUF1_HUMAN	SMAD specific E3 ubiquitin protein ligase 1	660	HECT.				BMP signaling pathway|cell differentiation|ectoderm development|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein export from nucleus|protein localization at cell surface|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|plasma membrane	activin binding|I-SMAD binding|R-SMAD binding|ubiquitin-protein ligase activity			endometrium(3)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|skin(2)|urinary_tract(1)	25	all_cancers(62;1.05e-08)|all_epithelial(64;4.34e-09)|Lung NSC(181;0.00902)|all_lung(186;0.0145)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)|Lung(104;0.224)			CCAGAACCACCGCACGATGTT	0.577000													5	19					0	0	1	0	0
OR4D11	219986	broad.mit.edu	37	11	59271959	59271959	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:59271959G>C	ENST00000313253.1	+	1	911	c.911G>C	c.(910-912)aGa>aCa	p.R304T		NM_001004706.1	NP_001004706.1	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D, member 11	304					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29						CTGAAGAGAAGACTCGTGCCT	0.522000													14	30					0	0	1	0	0
FUT2	2524	broad.mit.edu	37	19	49207215	49207215	+	Silent	SNP	C	C	T	rs144809245		TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:49207215C>T	ENST00000425340.2	+	2	1119	c.1002C>T	c.(1000-1002)gcC>gcT	p.A334A	FUT2_ENST00000391876.4_Silent_p.A334A	NM_000511.5|NM_001097638.2	NP_000502.4|NP_001091107.1	Q10981	FUT2_HUMAN	fucosyltransferase 2 (secretor status included)	334					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	galactoside 2-alpha-L-fucosyltransferase activity			breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(1)|lung(2)	7		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.00011)|all cancers(93;0.000238)|GBM - Glioblastoma multiforme(486;0.0164)|Epithelial(262;0.017)		CAGGGATTGCCGCAGACCTGT	0.552000													13	49					0	0	1	0	0
LRRC8E	80131	broad.mit.edu	37	19	7964331	7964331	+	Silent	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:7964331C>G	ENST00000306708.6	+	3	1025	c.924C>G	c.(922-924)ctC>ctG	p.L308L	AC010336.1_ENST00000539278.1_3'UTR	NM_001268284.1|NM_001268285.1|NM_025061.4	NP_001255213.1|NP_001255214.1|NP_079337.2	Q6NSJ5	LRC8E_HUMAN	leucine rich repeat containing 8 family, member E	308						integral to membrane				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(10)	35						AGGCCCACCTCTTCTCCAAGC	0.557000													5	24					0	0	1	0	0
C1orf56	54964	broad.mit.edu	37	1	151020727	151020727	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:151020727C>T	ENST00000368926.5	+	1	512	c.404C>T	c.(403-405)tCc>tTc	p.S135F		NM_017860.3	NP_060330.2	Q9BUN1	CA056_HUMAN	chromosome 1 open reading frame 56	135						extracellular region				endometrium(1)|kidney(1)|lung(3)|ovary(1)|prostate(1)	7	Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GCGGGGAGTTCCAGCACGAGG	0.577000													36	32					0	0	1	0	0
ITGA4	3676	broad.mit.edu	37	2	182399633	182399633	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:182399633C>G	ENST00000397033.2	+	27	3404	c.2974C>G	c.(2974-2976)Ctt>Gtt	p.L992V		NM_000885.4	NP_000876.3	P13612	ITA4_HUMAN	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	992					blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	ACTTATTGTACTTCTATTGAT	0.343000													28	81					0	0	1	0	0
SLC45A1	50651	broad.mit.edu	37	1	8390433	8390433	+	Silent	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:8390433C>A	ENST00000471889.1	+	5	1265	c.880C>A	c.(880-882)Cgg>Agg	p.R294R	SLC45A1_ENST00000377479.2_Silent_p.R328R|SLC45A1_ENST00000289877.8_Silent_p.R294R			Q9Y2W3	S45A1_HUMAN	solute carrier family 45, member 1	294					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(2)	33	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		GAGGCCGCTGCGGCCGCCGAG	0.697000													17	35					1.5739e-10	1.68594e-10	1	1	0
PDE1C	5137	broad.mit.edu	37	7	31918760	31918760	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:31918760C>T	ENST00000396184.3	-	5	478	c.274G>A	c.(274-276)Gac>Aac	p.D92N	PDE1C_ENST00000321453.7_Missense_Mutation_p.D92N|PDE1C_ENST00000396182.2_Missense_Mutation_p.D92N|PDE1C_ENST00000396191.1_Missense_Mutation_p.D92N|PDE1C_ENST00000396193.1_Missense_Mutation_p.D152N	NM_005020.2	NP_005011.1	Q14123	PDE1C_HUMAN	phosphodiesterase 1C, calmodulin-dependent 70kDa	92					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(38)|prostate(4)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	81			GBM - Glioblastoma multiforme(11;0.216)			GACTGAATGTCACTGAGCTCA	0.527000													5	33					0	0	1	0	0
IFI44	10561	broad.mit.edu	37	1	79116319	79116319	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:79116319G>C	ENST00000370747.4	+	2	524	c.439G>C	c.(439-441)Gaa>Caa	p.E147Q	IFI44_ENST00000495254.1_Intron|IFI44_ENST00000545124.1_Intron	NM_006417.4	NP_006408.3	Q8TCB0	IFI44_HUMAN	interferon-induced protein 44	147					response to virus	cytoplasm				central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	21						TCAGGATTATGAAGTTTTTCG	0.338000													10	38					0	0	1	0	0
TLDC1	57707	broad.mit.edu	37	16	84520349	84520349	+	Silent	SNP	G	G	C	rs150857959	byFrequency	TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr16:84520349G>C	ENST00000343629.6	-	5	1028	c.846C>G	c.(844-846)ctC>ctG	p.L282L	TLDC1_ENST00000535580.1_Silent_p.L255L	NM_020947.3	NP_065998.3			TBC/LysM-associated domain containing 1																		TGTGGCCACAGAGCTGGGAGA	0.597000													9	31					0	0	1	0	0
AHRR	57491	broad.mit.edu	37	5	428077	428077	+	Silent	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr5:428077G>C	ENST00000316418.5	+	9	974	c.930G>C	c.(928-930)ctG>ctC	p.L310L	AHRR_ENST00000506456.1_Silent_p.L148L|AHRR_ENST00000505113.1_Silent_p.L292L|AHRR_ENST00000512529.1_Silent_p.L138L	NM_020731.4	NP_065782.2	A9YTQ3	AHRR_HUMAN	aryl-hydrocarbon receptor repressor	292					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)|endometrium(4)|large_intestine(1)|lung(12)|prostate(1)	20			Epithelial(17;0.0011)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00354)|Lung(60;0.0863)			GCGCGCTCCTGAGGGCAAAAC	0.637000													5	11					0	0	1	0	0
HELQ	113510	broad.mit.edu	37	4	84374572	84374572	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr4:84374572C>T	ENST00000295488.3	-	2	986	c.824G>A	c.(823-825)gGa>gAa	p.G275E	HELQ_ENST00000510985.1_Missense_Mutation_p.G275E	NM_133636.2	NP_598375	Q8TDG4	HELQ_HUMAN	helicase, POLQ-like	275							ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(10)|lung(17)|ovary(2)|skin(2)	38						CTTCGCATTTCCAGTCATGGC	0.378000								Other identified genes with known or suspected DNA repair function					49	93					0	0	1	0	0
OSBPL2	9885	broad.mit.edu	37	20	60861760	60861760	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr20:60861760C>G	ENST00000313733.3	+	11	1320	c.1118C>G	c.(1117-1119)tCt>tGt	p.S373C	OSBPL2_ENST00000439951.2_Missense_Mutation_p.S281C|OSBPL2_ENST00000358053.2_Missense_Mutation_p.S361C	NM_144498.1	NP_653081.1	Q9H1P3	OSBL2_HUMAN	oxysterol binding protein-like 2	373					lipid transport		lipid binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	17	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;1.33e-06)			CCCCCCAACTCTGCCCAGGTC	0.657000													11	51					0	0	1	0	0
DDX26B	203522	broad.mit.edu	37	X	134681100	134681100	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:134681100C>A	ENST00000370752.4	+	6	986	c.652C>A	c.(652-654)Caa>Aaa	p.Q218K	DDX26B_ENST00000481908.1_3'UTR	NM_182540.4	NP_872346.3	Q5JSJ4	DX26B_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B	218	VWFA.									large_intestine(1)|lung(8)	9	Acute lymphoblastic leukemia(192;6.56e-05)					AATGTTGAATCAATGTTTAGA	0.328000													53	128					4.25531e-23	4.72649e-23	1	1	0
OR52K1	390036	broad.mit.edu	37	11	4510814	4510814	+	Silent	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:4510814C>A	ENST00000307632.3	+	1	706	c.684C>A	c.(682-684)ctC>ctA	p.L228L		NM_001005171.2	NP_001005171.2	Q8NGK4	O52K1_HUMAN	olfactory receptor, family 52, subfamily K, member 1	228					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(18)|skin(2)|stomach(1)	32		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.76e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0836)|LUSC - Lung squamous cell carcinoma(625;0.192)		AGGCAGTTCTCCAGCTTGCCT	0.488000													30	125					3.69857e-22	4.09864e-22	1	1	0
FRMPD4	9758	broad.mit.edu	37	X	12736650	12736650	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:12736650G>A	ENST00000380682.1	+	16	4211	c.3705G>A	c.(3703-3705)gtG>gtA	p.V1235V		NM_014728.3	NP_055543.2	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	1235					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			breast(1)|central_nervous_system(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)	22						CCACACCCGTGGAGTCGCCGC	0.597000													32	92					0	0	1	0	0
MATK	4145	broad.mit.edu	37	19	3789324	3789324	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:3789324C>T	ENST00000395045.2	-	2	359	c.22G>A	c.(22-24)Gaa>Aaa	p.E8K	MATK_ENST00000590821.1_5'UTR	NM_002378.3	NP_002369.2	P42679	MATK_HUMAN	megakaryocyte-associated tyrosine kinase	0					cell proliferation|mesoderm development|positive regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|skin(2)|stomach(2)|urinary_tract(1)	26		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		tctcttcgttcagcagggaaa	0.498000													7	21					0	0	1	0	0
DNAJC3	5611	broad.mit.edu	37	13	96438198	96438198	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr13:96438198C>T	ENST00000602402.1	+	10	1198	c.1081C>T	c.(1081-1083)Cag>Tag	p.Q361*	DNAJC3_ENST00000376795.6_Nonsense_Mutation_p.Q310*	NM_006260.4	NP_006251.1	Q13217	DNJC3_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 3	361					protein folding|response to unfolded protein|response to virus		heat shock protein binding|protein kinase inhibitor activity|unfolded protein binding	p.D362_Q367delDYETAQ(1)		NS(1)|breast(1)|kidney(4)|large_intestine(1)|lung(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.126)			GACAGCTATTCAGGATTATGA	0.343000													7	23					0	0	1	0	0
POTEG	404785	broad.mit.edu	37	14	19553704	19553704	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr14:19553704C>A	ENST00000409832.3	+	1	340	c.288C>A	c.(286-288)agC>agA	p.S96R		NM_001005356.2	NP_001005356.1	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	96										cervix(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(31)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	47						CACTCAGGAGCAAGATGGGCA	0.617000													12	235					1.96292e-10	2.098e-10	1	1	0
OSBPL3	26031	broad.mit.edu	37	7	24932039	24932039	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:24932039G>C	ENST00000313367.2	-	2	504	c.53C>G	c.(52-54)tCa>tGa	p.S18*	OSBPL3_ENST00000396431.1_Nonsense_Mutation_p.S18*|OSBPL3_ENST00000431825.2_Nonsense_Mutation_p.S18*|OSBPL3_ENST00000352860.1_Nonsense_Mutation_p.S18*|OSBPL3_ENST00000353930.1_Nonsense_Mutation_p.S18*|OSBPL3_ENST00000396429.1_Nonsense_Mutation_p.S18*|OSBPL3_ENST00000409069.1_Nonsense_Mutation_p.S18*	NM_015550.2	NP_056365.1	Q9H4L5	OSBL3_HUMAN	oxysterol binding protein-like 3	18					lipid transport		lipid binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(19)|prostate(1)|skin(3)|urinary_tract(1)	43						TGTGCTCCTTGAAGGTGATAC	0.423000													12	46					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179498774	179498774	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:179498774T>C	ENST00000589042.1	-	231	42676	c.42452A>G	c.(42451-42453)cAa>cGa	p.Q14151R	TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.Q11583R|TTN_ENST00000342175.6_Missense_Mutation_p.Q5278R|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.Q5211R|TTN_ENST00000460472.2_Missense_Mutation_p.Q5086R|TTN_ENST00000591111.1_Missense_Mutation_p.Q12510R|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000589487.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	12510	Fibronectin type-III 2.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTACTGTTTGATCTTCAAG	0.353000													30	52					0	0	1	0	0
TRIM54	57159	broad.mit.edu	37	2	27505742	27505742	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:27505742G>A	ENST00000296098.4	+	1	413	c.143G>A	c.(142-144)cGc>cAc	p.R48H	TRIM54_ENST00000380075.2_Missense_Mutation_p.R48H	NM_032546.3	NP_115935.3	Q9BYV2	TRI54_HUMAN	tripartite motif containing 54	48					cell differentiation|microtubule-based process|multicellular organismal development|negative regulation of microtubule depolymerization	microtubule|sarcomere	signal transducer activity|zinc ion binding	p.R32H(1)		cervix(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AACCTGTGCCGCAAATGTGCC	0.587000													4	297					0	0	1	0	0
HIST1H2AL	8332	broad.mit.edu	37	6	27833414	27833414	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:27833414C>T	ENST00000357320.2	+	1	381	c.282C>T	c.(280-282)ctC>ctT	p.L94L		NM_003511.2	NP_003502.1	P0C0S8	H2A1_HUMAN	histone cluster 1, H2al	94					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding			breast(1)|endometrium(1)|large_intestine(2)|lung(3)|urinary_tract(2)	9						ACGAGGAGCTCAACAAGCTGC	0.617000													9	108					0	0	1	0	0
SMARCA2	6595	broad.mit.edu	37	9	2110333	2110333	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr9:2110333G>A	ENST00000382203.1	+	24	3581	c.3372G>A	c.(3370-3372)ctG>ctA	p.L1124L	SMARCA2_ENST00000349721.2_Silent_p.L1124L|SMARCA2_ENST00000382194.1_Silent_p.L1124L|SMARCA2_ENST00000357248.2_Silent_p.L1124L			P51531	SMCA2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	1124	Helicase C-terminal.				chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		TTTTCTTGCTGAGCACAAGAG	0.473000													17	50					0	0	1	0	0
TBC1D8B	54885	broad.mit.edu	37	X	106046148	106046148	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:106046148C>T	ENST00000357242.5	+	1	239	c.65C>T	c.(64-66)tCc>tTc	p.S22F	TBC1D8B_ENST00000310452.2_Missense_Mutation_p.S22F|TBC1D8B_ENST00000276175.3_Missense_Mutation_p.S22F|TBC1D8B_ENST00000481617.2_Missense_Mutation_p.S22F	NM_017752.2	NP_060222.2	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	22						intracellular	calcium ion binding|Rab GTPase activator activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|liver(4)|lung(15)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						ATGGAAAGGTCCAACGACTAC	0.612000													7	43					0	0	1	0	0
GABBR1	2550	broad.mit.edu	37	6	29589917	29589917	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:29589917G>A	ENST00000377034.4	-	9	1364	c.1029C>T	c.(1027-1029)ttC>ttT	p.F343F	GABBR1_ENST00000377016.4_Silent_p.F281F|GABBR1_ENST00000355973.3_Silent_p.F226F|GABBR1_ENST00000377012.4_Silent_p.F226F|GABBR1_ENST00000376977.3_Silent_p.F343F	NM_001470.2	NP_001461.1	Q9UBS5	GABR1_HUMAN	gamma-aminobutyric acid (GABA) B receptor, 1	343					gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|extracellular region|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			endometrium(3)|kidney(1)|large_intestine(13)|liver(1)|lung(16)|ovary(5)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47					Baclofen(DB00181)|Progabide(DB00837)	GATCTGAGAAGAAACTCTGGC	0.517000													13	22					0	0	1	0	0
GPR37L1	9283	broad.mit.edu	37	1	202096982	202096982	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:202096982C>T	ENST00000367282.5	+	2	850	c.744C>T	c.(742-744)atC>atT	p.I248I		NM_004767.3	NP_004758.3	O60883	ETBR2_HUMAN	G protein-coupled receptor 37 like 1							integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)	18						GCCAATCCATCCTGGCCAAGT	0.647000													14	44					0	0	1	0	0
UROC1	131669	broad.mit.edu	37	3	126218907	126218907	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:126218907C>G	ENST00000290868.2	-	12	1289	c.1236G>C	c.(1234-1236)caG>caC	p.Q412H	UROC1_ENST00000383579.3_Missense_Mutation_p.Q472H	NM_144639.2	NP_653240.1	Q96N76	HUTU_HUMAN	urocanate hydratase 1	412					histidine catabolic process	cytosol	urocanate hydratase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(1)|skin(1)	39				GBM - Glioblastoma multiforme(114;0.17)		tACCTGCTCTCTGGGCCTCCA	0.627000													12	31					0	0	1	0	0
ZFP30	22835	broad.mit.edu	37	19	38134166	38134166	+	Splice_Site	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:38134166C>T	ENST00000351218.2	-	5	792	c.235G>A	c.(235-237)Gat>Aat	p.D79N	ZFP30_ENST00000392144.1_Splice_Site_p.D79N|ZFP30_ENST00000514101.2_Splice_Site_p.D79N|ZFP30_ENST00000589018.1_Splice_Site_p.G78S	NM_014898.2	NP_055713.1	Q9Y2G7	ZFP30_HUMAN	ZFP30 zinc finger protein	79					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	21			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CAGCACTTACCTAGAGTCCAT	0.488000													5	280					0	0	1	0	0
SNX1	6642	broad.mit.edu	37	15	64429794	64429794	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr15:64429794C>A	ENST00000353874.4	+	14	1438	c.1402C>A	c.(1402-1404)Cct>Act	p.P468T	SNX1_ENST00000559844.1_Missense_Mutation_p.P516T|SNX1_ENST00000261889.5_Intron|SNX1_ENST00000560829.1_Missense_Mutation_p.P298T|SNX1_ENST00000561026.1_Missense_Mutation_p.P451T			Q13596	SNX1_HUMAN	sorting nexin 1	516	BAR.				cell communication|early endosome to Golgi transport|endocytosis|intracellular protein transport	early endosome membrane|Golgi apparatus	phosphatidylinositol binding|protein binding|protein transporter activity			breast(1)|endometrium(1)|large_intestine(5)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	13						AGCCTTCCTTCCTGAGGCAAA	0.557000													17	17					1.56452e-12	1.69475e-12	1	1	0
SFI1	9814	broad.mit.edu	37	22	31942884	31942884	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr22:31942884G>A	ENST00000432498.1	+	5	769	c.376G>A	c.(376-378)Gaa>Aaa	p.E126K	SFI1_ENST00000400289.1_Missense_Mutation_p.E44K|SFI1_ENST00000443011.1_Missense_Mutation_p.E44K|SFI1_ENST00000540643.1_Missense_Mutation_p.E102K|SFI1_ENST00000414585.1_Missense_Mutation_p.E44K|SFI1_ENST00000400288.2_Missense_Mutation_p.E126K|SFI1_ENST00000443326.1_Missense_Mutation_p.E44K	NM_014775.3	NP_055590.2	A8K8P3	SFI1_HUMAN	Sfi1 homolog, spindle assembly associated (yeast)	126	Interaction with CETN2.				G2/M transition of mitotic cell cycle	centriole|cytosol				NS(2)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(3)|upper_aerodigestive_tract(3)	38						GAAGGTCTTCGAAGAATGGAA	0.413000													13	56					0	0	1	0	0
PDGFRA	5156	broad.mit.edu	37	4	55141105	55141105	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr4:55141105C>G	ENST00000257290.5	+	12	2082	c.1751C>G	c.(1750-1752)tCa>tGa	p.S584*	FIP1L1_ENST00000507166.1_Nonsense_Mutation_p.S344*	NM_006206.4	NP_006197.1	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor, alpha polypeptide	584					cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			NS(1)|autonomic_ganglia(1)|bone(1)|breast(4)|central_nervous_system(17)|cervix(1)|endometrium(4)|eye(1)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(22)|kidney(6)|large_intestine(26)|liver(4)|lung(48)|ovary(4)|prostate(6)|skin(11)|small_intestine(49)|soft_tissue(727)|stomach(32)|urinary_tract(1)	967	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	CCTTATGACTCAAGATGGGAG	0.443000			"""Mis, O, T"""	FIP1L1	"""GIST, idiopathic hypereosinophilic syndrome, paediatric GBM"""				Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Intestinal Neurofibromatosis	TSP Lung(21;0.16)			30	34					0	0	1	0	0
TRHDE	29953	broad.mit.edu	37	12	72666943	72666943	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:72666943G>C	ENST00000261180.4	+	1	481	c.385G>C	c.(385-387)Gag>Cag	p.E129Q	TRHDE-AS1_ENST00000426250.3_RNA	NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	129					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						GTCGGAGGAGGAGCGGGAGCC	0.716000													6	11					0	0	1	0	0
TRMT1	55621	broad.mit.edu	37	19	13227003	13227003	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:13227003C>T	ENST00000592062.1	-	3	781	c.211G>A	c.(211-213)Gag>Aag	p.E71K	TRMT1_ENST00000357720.4_Missense_Mutation_p.E71K|TRMT1_ENST00000437766.1_Missense_Mutation_p.E71K|TRMT1_ENST00000221504.8_Missense_Mutation_p.E71K|TRMT1_ENST00000592892.1_5'UTR			Q9NXH9	TRM1_HUMAN	tRNA methyltransferase 1 homolog (S. cerevisiae)	71							RNA binding|tRNA (guanine-N2-)-methyltransferase activity|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(19;6.08e-22)	GBM - Glioblastoma multiforme(1328;0.0356)		TAAAAGACCTCGTTGGCACTG	0.597000													46	50					0	0	1	0	0
ACAD10	80724	broad.mit.edu	37	12	112184921	112184921	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:112184921G>C	ENST00000455480.2	+	16	2595	c.2418G>C	c.(2416-2418)caG>caC	p.Q806H	ACAD10_ENST00000392636.2_Missense_Mutation_p.Q377H|ACAD10_ENST00000413681.3_3'UTR|ACAD10_ENST00000313698.4_Missense_Mutation_p.Q775H	NM_001136538.1	NP_001130010.1	Q6JQN1	ACD10_HUMAN	acyl-CoA dehydrogenase family, member 10	775							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(17)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(5)	47						CCGAAGCGCAGAAGGCTCGCT	0.597000													5	43					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77641944	77641944	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr13:77641944C>A	ENST00000407578.2	-	71	12493	c.12227G>T	c.(12226-12228)aGc>aTc	p.S4076I	MYCBP2_ENST00000357337.6_Missense_Mutation_p.S4038I|MYCBP2_ENST00000544440.2_Missense_Mutation_p.S4038I	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	4038					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TCCTATGATGCTGGCCAGACG	0.413000													27	48					6.07407e-21	6.72337e-21	1	1	0
CNTF	1270	broad.mit.edu	37	11	58391530	58391530	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:58391530G>C	ENST00000361987.4	+	2	218	c.138G>C	c.(136-138)aaG>aaC	p.K46N	ZFP91-CNTF_ENST00000389919.4_3'UTR	NM_000614.3	NP_000605.1	P26441	CNTF_HUMAN	ciliary neurotrophic factor	46					ciliary neurotrophic factor-mediated signaling pathway|growth|negative regulation of neuron apoptosis|positive regulation of tyrosine phosphorylation of Stat3 protein		ciliary neurotrophic factor receptor binding|growth factor activity|interleukin-6 receptor binding			NS(1)|breast(1)|kidney(2)|large_intestine(4)|lung(1)|ovary(1)	10		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				GCCTGAACAAGAACATCAACC	0.512000													10	62					0	0	1	0	0
OR51I1	390063	broad.mit.edu	37	11	5461964	5461964	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:5461964A>C	ENST00000380211.1	-	1	780	c.781T>G	c.(781-783)Tcc>Gcc	p.S261A	HBG2_ENST00000380252.1_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380259.2_Intron|AC104389.28_ENST00000415970.1_RNA	NM_001005288.2	NP_001005288.1	Q9H343	O51I1_HUMAN	olfactory receptor, family 51, subfamily I, member 1	261					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	30		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGAATCATGGAGACAGCAATT	0.488000													7	36					0	0	1	0	0
CEACAM5	1048	broad.mit.edu	37	19	42225092	42225092	+	Silent	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:42225092C>G	ENST00000221992.6	+	8	2136	c.2022C>G	c.(2020-2022)gtC>gtG	p.V674V	CEACAM5_ENST00000405816.1_Silent_p.V674V|CEA_ENST00000598976.1_Intron|CEACAM5_ENST00000398599.4_Silent_p.V673V	NM_004363.2	NP_004354.2	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 5	674	Ig-like 7.					anchored to membrane|basolateral plasma membrane|integral to plasma membrane				breast(1)|endometrium(3)|kidney(5)|large_intestine(4)|lung(10)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	34				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		GCATCACAGTCTCTGGTAAGT	0.458000													18	59					0	0	1	0	0
PPP1R16A	84988	broad.mit.edu	37	8	145724372	145724372	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr8:145724372G>C	ENST00000292539.4	+	4	1321	c.404G>C	c.(403-405)aGt>aCt	p.S135T	CTD-2517M22.14_ENST00000532766.1_RNA|CTD-2517M14.5_ENST00000569326.1_RNA|PPP1R16A_ENST00000435887.1_Missense_Mutation_p.S135T			Q96I34	PP16A_HUMAN	protein phosphatase 1, regulatory subunit 16A	135						plasma membrane	protein binding			NS(1)|endometrium(1)|kidney(2)|lung(3)|prostate(1)	8	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			GCCTGTGACAGTGAGTGCTGG	0.627000													5	18					0	0	1	0	0
THBS4	7060	broad.mit.edu	37	5	79372747	79372747	+	Silent	SNP	C	C	A	rs142782610	by1000genomes	TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr5:79372747C>A	ENST00000350881.2	+	16	2152	c.1962C>A	c.(1960-1962)acC>acA	p.T654T	THBS4_ENST00000511733.1_Silent_p.T563T|CTD-2201I18.1_ENST00000503007.1_RNA|CTD-2201I18.1_ENST00000514042.1_RNA	NM_003248.4	NP_003239.2	P35443	TSP4_HUMAN	thrombospondin 4	654					endothelial cell-cell adhesion|myoblast migration|negative regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation	basement membrane|extracellular space	calcium ion binding|heparin binding|integrin binding|structural molecule activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|stomach(3)	34		Lung NSC(167;0.00328)|all_lung(232;0.00355)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-45)|Epithelial(54;1.77e-39)|all cancers(79;3.2e-34)		AGCTGGACACCGATAAGGATG	0.557000													43	54					5.44703e-19	6.00858e-19	1	1	0
SOS1	6654	broad.mit.edu	37	2	39250095	39250095	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:39250095C>G	ENST00000426016.1	-	11	1560	c.1474G>C	c.(1474-1476)Gaa>Caa	p.E492Q	SOS1_ENST00000472480.1_5'UTR|SOS1_ENST00000395038.2_Missense_Mutation_p.E492Q|SOS1_ENST00000402219.2_Missense_Mutation_p.E492Q			Q07889	SOS1_HUMAN	son of sevenless homolog 1 (Drosophila)	492	PH.				apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(29)|ovary(4)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	75		all_hematologic(82;0.21)				AAAAACTTTTCTTTAAGACGA	0.318000									Noonan syndrome				48	50					0	0	1	0	0
TMC2	117532	broad.mit.edu	37	20	2591187	2591187	+	Silent	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr20:2591187C>G	ENST00000358864.1	+	12	1551	c.1536C>G	c.(1534-1536)ctC>ctG	p.L512L	TMC2_ENST00000496948.1_3'UTR	NM_080751.2	NP_542789.2	Q8TDI7	TMC2_HUMAN	transmembrane channel-like 2	512						integral to membrane				NS(1)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						TCTTTGCACTCTTCCTGGGGA	0.537000													9	55					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22204973	22204973	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:22204973C>G	ENST00000374695.3	-	20	2649	c.2570G>C	c.(2569-2571)gGa>gCa	p.G857A		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	857	Laminin EGF-like 3.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GCCCTCGTATCCGGGGGCACA	0.677000													6	13					0	0	1	0	0
PCDHB11	56125	broad.mit.edu	37	5	140580018	140580018	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr5:140580018G>C	ENST00000354757.3	+	1	671	c.671G>C	c.(670-672)gGa>gCa	p.G224A	PCDHB11_ENST00000536699.1_Intron	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		224	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCAGGTCTGGAACTGCCTTG	0.517000													27	41					0	0	1	0	0
AICDA	57379	broad.mit.edu	37	12	8757435	8757435	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:8757435G>T	ENST00000229335.6	-	4	614	c.511C>A	c.(511-513)Cgt>Agt	p.R171S	AICDA_ENST00000537228.1_Missense_Mutation_p.R161S	NM_020661.2	NP_065712.1	Q9GZX7	AICDA_HUMAN	activation-induced cytidine deaminase	171					B cell differentiation|DNA demethylation|mRNA processing|negative regulation of methylation-dependent chromatin silencing	cytoplasm	cytidine deaminase activity|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(4)|ovary(2)|pancreas(1)	16	Lung SC(5;0.184)					CTGGAGAGACGAACTGAATTT	0.368000													27	135					1.7881e-09	1.90903e-09	1	1	0
GPR137	56834	broad.mit.edu	37	11	64055319	64055319	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:64055319G>A	ENST00000539851.1	+	4	1001	c.534G>A	c.(532-534)gtG>gtA	p.V178V	GPR137_ENST00000313074.3_Silent_p.V178V|GPR137_ENST00000377702.4_Silent_p.V178V|GPR137_ENST00000438980.2_Silent_p.V178V|GPR137_ENST00000411458.1_Silent_p.V236V	NM_001177358.1	NP_001170829.1	Q96N19	G137A_HUMAN	G protein-coupled receptor 137	178						integral to membrane				central_nervous_system(1)|endometrium(3)|kidney(1)|lung(4)|skin(1)	10						GCGTCCTGGTGAGCGACTCCC	0.672000													12	32					0	0	1	0	0
BCKDHA	593	broad.mit.edu	37	19	41916898	41916898	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:41916898A>G	ENST00000269980.2	+	3	727	c.359A>G	c.(358-360)tAt>tGt	p.Y120C	BCKDHA_ENST00000595085.1_Missense_Mutation_p.Y154C|CTC-435M10.3_ENST00000540732.1_Missense_Mutation_p.Y154C|BCKDHA_ENST00000457836.2_Missense_Mutation_p.Y98C	NM_000709.3|NM_001164783.1	NP_000700.1|NP_001158255.1	P12694	ODBA_HUMAN	branched chain keto acid dehydrogenase E1, alpha polypeptide	120					branched chain family amino acid catabolic process	mitochondrial alpha-ketoglutarate dehydrogenase complex	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|alpha-ketoacid dehydrogenase activity|carboxy-lyase activity|metal ion binding|protein binding			central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)	10						CGCATCCTCTATGAGTCTCAG	0.592000													50	112					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38765020	38765020	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:38765020C>A	ENST00000449082.2	-	18	3252	c.3253G>T	c.(3253-3255)Gag>Tag	p.E1085*		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1085					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GTGCTGCCCTCAGAGGAGCTT	0.597000													3	14					1	1	1	1	0
NRBP1	29959	broad.mit.edu	37	2	27659664	27659664	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:27659664G>C	ENST00000233557.3	+	9	1538	c.706G>C	c.(706-708)Gag>Cag	p.E236Q	NRBP1_ENST00000379852.3_Missense_Mutation_p.E236Q|NRBP1_ENST00000379863.3_Missense_Mutation_p.E244Q			Q9UHY1	NRBP_HUMAN	nuclear receptor binding protein 1	236	Protein kinase.				ER to Golgi vesicle-mediated transport|gene expression|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cell cortex|endomembrane system|lamellipodium|membrane|nucleoplasm	ATP binding|protein homodimerization activity|protein kinase activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19	Acute lymphoblastic leukemia(172;0.155)					TTGTCGAGAAGAGCAGAAGAA	0.478000													18	90					0	0	1	0	0
HERC4	26091	broad.mit.edu	37	10	69750954	69750954	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr10:69750954T>G	ENST00000395198.3	-	12	1521	c.1274A>C	c.(1273-1275)gAg>gCg	p.E425A	HERC4_ENST00000373700.4_Missense_Mutation_p.E425A|HERC4_ENST00000412272.2_Missense_Mutation_p.E425A|HERC4_ENST00000395187.2_3'UTR|HERC4_ENST00000277817.6_Missense_Mutation_p.E315A	NM_022079.2	NP_071362.1	Q5GLZ8	HERC4_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 4	425					cell differentiation|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|spermatogenesis	cytosol	ubiquitin-protein ligase activity			NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	27						TCCATCTATCTCACTAAAAAA	0.239000													9	23					0	0	1	0	0
SLC1A4	6509	broad.mit.edu	37	2	65243804	65243804	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:65243804C>G	ENST00000234256.3	+	5	1274	c.1031C>G	c.(1030-1032)tCc>tGc	p.S344C	SLC1A4_ENST00000531327.1_Intron	NM_003038.4	NP_003029.2	P43007	SATT_HUMAN	solute carrier family 1 (glutamate/neutral amino acid transporter), member 4	344					cellular nitrogen compound metabolic process|cognition|synaptic transmission, glutamatergic	intermediate filament|melanosome	chloride channel activity|L-alanine transmembrane transporter activity|L-cystine transmembrane transporter activity|L-hydroxyproline transmembrane transporter activity|L-proline transmembrane transporter activity|L-serine transmembrane transporter activity|L-threonine transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|pancreas(1)|prostate(1)|urinary_tract(1)	13					L-Alanine(DB00160)	GCTACCTGCTCCAGGTGAGTG	0.478000													26	24					0	0	1	0	0
KCNJ2	3759	broad.mit.edu	37	17	68171347	68171347	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr17:68171347T>C	ENST00000243457.3	+	2	550	c.167T>C	c.(166-168)gTt>gCt	p.V56A	KCNJ2_ENST00000535240.1_Missense_Mutation_p.V56A	NM_000891.2	NP_000882.1	P63252	IRK2_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 2	56					synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(13)|skin(1)|urinary_tract(1)	25	Breast(10;1.64e-08)					CACTGTAATGTTCAGTTCATC	0.522000													8	52					0	0	1	0	0
SLC6A9	6536	broad.mit.edu	37	1	44476472	44476472	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:44476472A>G	ENST00000372310.3	-	3	278	c.113T>C	c.(112-114)cTg>cCg	p.L38P	SLC6A9_ENST00000475075.2_Intron|SLC6A9_ENST00000492434.2_Intron|SLC6A9_ENST00000360584.2_Missense_Mutation_p.L111P|SLC6A9_ENST00000537678.1_Intron|SLC6A9_ENST00000372306.3_Missense_Mutation_p.L38P|SLC6A9_ENST00000372307.3_5'UTR|SLC6A9_ENST00000357730.2_Missense_Mutation_p.L57P	NM_001024845.2	NP_001020016.1	P48067	SC6A9_HUMAN	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	111						integral to plasma membrane|membrane fraction	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			endometrium(3)|large_intestine(8)|lung(7)|ovary(1)|skin(1)|urinary_tract(2)	22	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			Glycine(DB00145)	CACGCTCGTCAGTACAAACTC	0.622000													24	37					0	0	1	0	0
WHSC1L1	54904	broad.mit.edu	37	8	38133860	38133860	+	Silent	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr8:38133860G>C	ENST00000317025.8	-	23	4543	c.4026C>G	c.(4024-4026)ccC>ccG	p.P1342P	WHSC1L1_ENST00000527502.1_Silent_p.P1331P|RP11-513D5.5_ENST00000529325.1_RNA|WHSC1L1_ENST00000433384.2_Silent_p.P1293P	NM_023034.1	NP_075447.1	Q9BZ95	NSD3_HUMAN	Wolf-Hirschhorn syndrome candidate 1-like 1	1342					cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	24	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)			GGTATGCTTTGGGACAGTCTT	0.448000			T	NUP98	AML								4	71					0	0	1	0	0
THOC2	57187	broad.mit.edu	37	X	122757987	122757987	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:122757987C>A	ENST00000245838.8	-	27	3273	c.3242G>T	c.(3241-3243)gGt>gTt	p.G1081V	THOC2_ENST00000355725.4_Missense_Mutation_p.G1081V|THOC2_ENST00000491737.1_Missense_Mutation_p.G966V	NM_001081550.1	NP_001075019.1	Q8NI27	THOC2_HUMAN	THO complex 2	1081					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			breast(2)|endometrium(13)|kidney(4)|large_intestine(11)|lung(26)|ovary(3)|skin(1)|upper_aerodigestive_tract(3)	63						CTTATTTCCACCATCAAATCC	0.318000													12	59					3.03607e-14	3.31866e-14	1	1	0
OR56A4	120793	broad.mit.edu	37	11	6023938	6023938	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:6023938G>C	ENST00000330728.4	-	1	486	c.441C>G	c.(439-441)atC>atG	p.I147M		NM_001005179.2	NP_001005179.2	Q8NGH8	O56A4_HUMAN	olfactory receptor, family 56, subfamily A, member 4	95					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(4)|large_intestine(5)|lung(17)|ovary(1)|skin(1)|urinary_tract(1)	32		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTGGGAAGCTGATCGACCTGA	0.542000													11	44					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135453603	135453603	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:135453603G>C	ENST00000394143.1	+	14	7804	c.7513G>C	c.(7513-7515)Gag>Cag	p.E2505Q	GPR112_ENST00000394141.1_Missense_Mutation_p.E2300Q|GPR112_ENST00000287534.4_Missense_Mutation_p.E2303Q|GPR112_ENST00000412101.1_Missense_Mutation_p.E2300Q|GPR112_ENST00000370652.1_Missense_Mutation_p.E2505Q	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	2505					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					ACAATGTGATGAGATAAGTAT	0.323000													9	82					0	0	1	0	0
SELO	83642	broad.mit.edu	37	22	50648640	50648640	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr22:50648640G>A	ENST00000380903.2	+	4	1028	c.970G>A	c.(970-972)Gag>Aag	p.E324K	SELO_ENST00000492092.1_3'UTR	NM_031454.1	NP_113642.1	Q9BVL4	SELO_HUMAN															all_cancers(38;1.14e-10)|all_epithelial(38;2.12e-09)|all_lung(38;7.01e-05)|Breast(42;0.000523)|Lung NSC(38;0.0018)|Ovarian(80;0.0365)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.105)		GATGGTGGCCGAGTGGCAGTG	0.657000											OREG0026676	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	13					0	0	1	0	0
ZNF358	140467	broad.mit.edu	37	19	7584149	7584149	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:7584149C>T	ENST00000599312.1	+	2	119	c.119C>T	c.(118-120)tCa>tTa	p.S40L	ZNF358_ENST00000394341.2_Silent_p.V7V|ZNF358_ENST00000597229.1_Silent_p.V7V																							CAGTCCTGGTCAGGAACCCAG	0.587000													9	60					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100361433	100361433	+	RNA	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:100361433C>T	ENST00000542585.1	+	0	4139				ZAN_ENST00000449052.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000546292.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TTGCAGGTGTCAGAAGTACCA	0.597000													39	47					0	0	1	0	0
ZNF524	147807	broad.mit.edu	37	19	56113490	56113490	+	Silent	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:56113490C>G	ENST00000591046.1	+	1	246	c.12C>G	c.(10-12)ccC>ccG	p.P4P	ZNF524_ENST00000301073.3_Silent_p.P4P			Q96C55	ZN524_HUMAN	zinc finger protein 524	4					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|large_intestine(2)|lung(6)|prostate(1)	10			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)		TGGACACCCCCAGCCCAGACC	0.657000													5	74					0	0	1	0	0
COL5A2	1290	broad.mit.edu	37	2	189918914	189918914	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:189918914G>C	ENST00000374866.3	-	36	2690	c.2416C>G	c.(2416-2418)Cca>Gca	p.P806A		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	806					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			GCCGGACCTGGAGGGCCCAAA	0.403000													10	74					0	0	1	0	0
GLB1	2720	broad.mit.edu	37	3	33087665	33087665	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:33087665C>T	ENST00000307363.5	-	10	1159	c.1015G>A	c.(1015-1017)Gag>Aag	p.E339K	GLB1_ENST00000307377.8_Missense_Mutation_p.E208K|GLB1_ENST00000399402.3_Missense_Mutation_p.E309K|GLB1_ENST00000445488.2_Missense_Mutation_p.E387K	NM_000404.2	NP_000395	P16278	BGAL_HUMAN	galactosidase, beta 1	339					carbohydrate metabolic process	lysosome|perinuclear region of cytoplasm	beta-galactosidase activity|cation binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	21		Melanoma(143;0.104)				TCCCCAGCCTCACTCAGTGGG	0.517000													23	55					0	0	1	0	0
CEP128	145508	broad.mit.edu	37	14	81259106	81259106	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr14:81259106G>A	ENST00000555265.1	-	14	1933	c.1558C>T	c.(1558-1560)Cag>Tag	p.Q520*	CEP128_ENST00000281129.3_Nonsense_Mutation_p.Q520*			Q6ZU80	CE128_HUMAN	centrosomal protein 128kDa	520						centriole|spindle pole				NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	51						TTTTATACCTGATTATTCTTG	0.373000													19	54					0	0	1	0	0
MAST1	22983	broad.mit.edu	37	19	12984486	12984486	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:12984486C>T	ENST00000251472.4	+	26	3554	c.3515C>T	c.(3514-3516)tCg>tTg	p.S1172L		NM_014975.2	NP_055790.1	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase 1	1172					cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(20)|ovary(5)|prostate(5)|skin(3)	56						TCGTCGGCGTCGCACCACATT	0.662000													6	10					0	0	1	0	0
LRRC37A4P	55073	broad.mit.edu	37	17	43587569	43587569	+	RNA	SNP	G	G	C	rs149697015	by1000genomes	TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr17:43587569G>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							aactccgtctgaaaagaaaag	0.443000													3	10					0	0	1	0	0
DHX9	1660	broad.mit.edu	37	1	182852729	182852729	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:182852729G>C	ENST00000367549.3	+	26	3329	c.3219G>C	c.(3217-3219)aaG>aaC	p.K1073N	DHX9_ENST00000485081.1_3'UTR	NM_001357.4	NP_001348.2	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 9	1073					CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(10)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	49						TTGCCTCCAAGAAAGTCCAAT	0.418000													25	83					0	0	1	0	0
DYTN	391475	broad.mit.edu	37	2	207559548	207559548	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:207559548G>C	ENST00000452335.2	-	8	889	c.773C>G	c.(772-774)tCt>tGt	p.S258C		NM_001093730.1	NP_001087199.1	A2CJ06	DYTN_HUMAN	dystrotelin	258						plasma membrane	zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(24)|ovary(1)|upper_aerodigestive_tract(1)	36				LUSC - Lung squamous cell carcinoma(261;0.082)|Epithelial(149;0.129)|Lung(261;0.153)		GTGAAGACCAGATAAGAAACA	0.398000													6	43					0	0	1	0	0
TRO	7216	broad.mit.edu	37	X	54957733	54957733	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:54957733C>G	ENST00000319167.8	+	13	2195	c.2083C>G	c.(2083-2085)Caa>Gaa	p.Q695E	TRO_ENST00000375022.4_Missense_Mutation_p.Q695E|TRO_ENST00000375041.2_3'UTR|TRO_ENST00000173898.7_3'UTR|TRO_ENST00000420798.2_3'UTR|TRO_ENST00000399736.1_Missense_Mutation_p.Q298E	NM_016157.3	NP_057241.2	Q12816	TROP_HUMAN	trophinin	0					embryo implantation|homophilic cell adhesion	integral to plasma membrane				breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|skin(2)|urinary_tract(1)	37						ACACAGCAGTCAAGGCAGTTA	0.423000													20	74					0	0	1	0	0
POLR1C	9533	broad.mit.edu	37	6	43488737	43488737	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:43488737G>C	ENST00000372389.3	+	8	961	c.873G>C	c.(871-873)gaG>gaC	p.E291D	POLR1C_ENST00000372344.2_Missense_Mutation_p.E241D|POLR1C_ENST00000304004.3_Missense_Mutation_p.E291D	NM_203290.2	NP_976035.1	O15160	RPAC1_HUMAN	polymerase (RNA) I polypeptide C, 30kDa	291					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein dimerization activity			kidney(1)|large_intestine(2)|lung(1)|prostate(1)	5	all_cancers(18;3.79e-05)|Lung NSC(15;0.00217)|all_lung(25;0.00536)		Colorectal(64;0.00245)|all cancers(41;0.00511)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0711)			TCCGGAATGAGAAGCTAAAGA	0.468000													21	67					0	0	1	0	0
TRIM67	440730	broad.mit.edu	37	1	231337118	231337118	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:231337118G>A	ENST00000444294.3	+	5	2247	c.1389G>A	c.(1387-1389)ctG>ctA	p.L463L	TRIM67_ENST00000366652.2_Silent_p.L463L|TRIM67_ENST00000449018.3_Silent_p.L401L|TRIM67_ENST00000366653.5_Silent_p.L463L	NM_001004342.3	NP_001004342.3	Q6ZTA4	TRI67_HUMAN	tripartite motif containing 67	463	COS.					cytoplasm|cytoskeleton	zinc ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29	Breast(184;0.0871)	all_cancers(173;0.189)|Prostate(94;0.167)				CAGATGCTCTGATCAAGCGCG	0.527000													8	16					0	0	1	0	0
DNMT3L	29947	broad.mit.edu	37	21	45681115	45681115	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr21:45681115C>G	ENST00000270172.3	-	2	511	c.28G>C	c.(28-30)Gag>Cag	p.E10Q	DNMT3L_ENST00000418993.1_Missense_Mutation_p.E10Q	NM_013369.3	NP_037501.2	Q9UJW3	DNM3L_HUMAN	DNA (cytosine-5-)-methyltransferase 3-like	10					DNA methylation|negative regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|spermatogenesis	cytosol	enzyme activator activity|enzyme binding|metal ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(3)	11				Colorectal(79;0.0165)|READ - Rectum adenocarcinoma(84;0.0781)		GGCTCGGCCTCTGGGTCCAGG	0.602000													5	67					0	0	1	0	0
AKAP17A	8227	broad.mit.edu	37	X	1720174	1720174	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:1720174G>A	ENST00000313871.3	+	5	1971	c.1775G>A	c.(1774-1776)gGa>gAa	p.G592E		NM_005088.2	NP_005079.2	Q02040	AK17A_HUMAN	A kinase (PRKA) anchor protein 17A	592	Arg-rich.				B cell activation|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|signal transduction	nuclear speck|spliceosomal complex	nucleotide binding|protein binding|RNA binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)	26						CGGGCCACCGGAGACGGGCTT	0.706000													5	34					0	0	1	0	0
KCNK2	3776	broad.mit.edu	37	1	215256745	215256745	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:215256745C>A	ENST00000444842.2	+	1	167	c.17C>A	c.(16-18)tCg>tAg	p.S6*	KCNK2_ENST00000391894.2_Intron|KCNK2_ENST00000391895.2_Intron	NM_001017425.2|NM_014217.3	NP_001017425.2|NP_055032.1	O95069	KCNK2_HUMAN	potassium channel, subfamily K, member 2	6							outward rectifier potassium channel activity	p.S6W(2)		endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|upper_aerodigestive_tract(1)	30				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)	CCCAGCGCCTCGCGGGAGAGA	0.547000													13	32					6.49762e-13	7.05435e-13	1	1	0
ZBTB4	57659	broad.mit.edu	37	17	7366392	7366392	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr17:7366392C>G	ENST00000311403.4	-	4	2248	c.1909G>C	c.(1909-1911)Gag>Cag	p.E637Q	ZBTB4_ENST00000380599.4_Missense_Mutation_p.E637Q	NM_020899.3	NP_065950.2	Q9P1Z0	ZBTB4_HUMAN	zinc finger and BTB domain containing 4	637	Glu-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(7)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|prostate(3)|skin(6)	36		Colorectal(1115;3.46e-05)|Myeloproliferative disorder(207;0.0255)		COAD - Colon adenocarcinoma(228;4.1e-06)|READ - Rectum adenocarcinoma(115;0.0642)		tcgtcctcctcactctcctcc	0.602000													7	3					0	0	1	0	0
DDX19B	11269	broad.mit.edu	37	16	70349882	70349882	+	Silent	SNP	T	T	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr16:70349882T>G	ENST00000288071.6	+	4	416	c.171T>G	c.(169-171)gcT>gcG	p.A57A	DDX19B_ENST00000393657.2_5'UTR|RP11-529K1.3_ENST00000567706.1_Silent_p.A57A|RP11-529K1.2_ENST00000562077.1_RNA|DDX19B_ENST00000355992.3_Silent_p.A57A|DDX19B_ENST00000563206.1_Silent_p.A62A|DDX19B_ENST00000570055.1_3'UTR|DDX19B_ENST00000568625.1_5'UTR|DDX19B_ENST00000563392.1_5'UTR|DDX19B_ENST00000451014.3_Silent_p.A62A	NM_007242.5	NP_009173.1	Q9UMR2	DD19B_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B	57					mRNA export from nucleus|protein transport|transmembrane transport	cytoplasm|nuclear membrane|nuclear pore	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(1)|prostate(1)	9		Ovarian(137;0.0694)				AGGACAGAGCTGCCCAGTCCT	0.428000													41	120					0	0	1	0	0
SIPA1L1	26037	broad.mit.edu	37	14	72139167	72139167	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr14:72139167G>A	ENST00000555818.1	+	9	3280	c.2932G>A	c.(2932-2934)Gag>Aag	p.E978K	SIPA1L1_ENST00000537413.1_Missense_Mutation_p.E453K|SIPA1L1_ENST00000358550.2_Missense_Mutation_p.E978K|SIPA1L1_ENST00000381232.3_Missense_Mutation_p.E978K	NM_001284247.1|NM_015556.1	NP_001271176.1|NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	978	PDZ.				actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		GGCGGATGTGGAGCCCTACGG	0.562000													9	46					0	0	1	0	0
IL1RAP	3556	broad.mit.edu	37	3	190326925	190326925	+	Silent	SNP	T	T	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:190326925T>C	ENST00000412504.2	+	4	744	c.492T>C	c.(490-492)gaT>gaC	p.D164D	IL1RAP_ENST00000422485.1_Silent_p.D164D|IL1RAP_ENST00000439062.1_Silent_p.D164D|IL1RAP_ENST00000422940.1_Silent_p.D164D|IL1RAP_ENST00000072516.3_Silent_p.D164D|IL1RAP_ENST00000317757.3_Silent_p.D164D|IL1RAP_ENST00000434491.1_Silent_p.D23D|IL1RAP_ENST00000443369.2_Silent_p.D164D|IL1RAP_ENST00000447382.1_Silent_p.D164D			Q9NPH3	IL1AP_HUMAN	interleukin 1 receptor accessory protein	164	Ig-like C2-type 2.				inflammatory response|innate immune response|protein complex assembly	extracellular region|integral to plasma membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	20	all_cancers(143;3.61e-10)|Ovarian(172;0.0733)|Breast(254;0.21)		Lung(62;1.95e-06)|LUSC - Lung squamous cell carcinoma(58;2.05e-06)	GBM - Glioblastoma multiforme(93;0.00851)		CAAATGTAGATGGATATTTTC	0.348000													33	66					0	0	1	0	0
PKDREJ	10343	broad.mit.edu	37	22	46654619	46654619	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr22:46654619A>T	ENST00000253255.5	-	1	4600	c.4601T>A	c.(4600-4602)cTc>cAc	p.L1534H		NM_006071.1	NP_006062.1	Q9NTG1	PKDRE_HUMAN	polycystin (PKD) family receptor for egg jelly	1534					acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			NS(2)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(4)|kidney(5)|large_intestine(21)|lung(16)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	73		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		ATTTGGCCCGAGGGTCTCCGG	0.478000													34	199					0	0	1	0	0
FAM122B	159090	broad.mit.edu	37	X	133915913	133915913	+	Silent	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:133915913G>C	ENST00000370790.1	-	8	1465	c.537C>G	c.(535-537)ctC>ctG	p.L179L	FAM122B_ENST00000486347.1_Silent_p.L180L|FAM122B_ENST00000343004.5_Silent_p.L198L|FAM122B_ENST00000493333.1_5'UTR|FAM122B_ENST00000298090.6_Silent_p.L198L	NM_001166599.2|NM_145284.5	NP_001160071.1|NP_660327.2	Q7Z309	F122B_HUMAN	family with sequence similarity 122B	179										breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|skin(1)	6	Acute lymphoblastic leukemia(192;0.000127)					TGCCTTGGAAGAGTCTCTTGG	0.363000													40	87					0	0	1	0	0
ZNF606	80095	broad.mit.edu	37	19	58489891	58489891	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:58489891C>G	ENST00000341164.4	-	7	2777	c.2157G>C	c.(2155-2157)gaG>gaC	p.E719D	ZNF606_ENST00000536132.1_Missense_Mutation_p.E629D	NM_025027.3	NP_079303.2	Q8WXB4	ZN606_HUMAN	zinc finger protein 606	719					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.E719D(2)		NS(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)		GGGATGAACTCTCATTAAATG	0.368000													52	68					0	0	1	0	0
RUSC1-AS1	284618	broad.mit.edu	37	1	155290466	155290466	+	RNA	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:155290466C>G	ENST00000446880.1	-	0	410				RUSC1-AS1_ENST00000450199.1_RNA|RUSC1-AS1_ENST00000543656.1_RNA|RUSC1-AS1_ENST00000443642.1_RNA			Q66K80	RUAS1_HUMAN																			TCTTGTGGTTCTGTTCTTGCT	0.557000													9	17					0	0	1	0	0
MMRN1	22915	broad.mit.edu	37	4	90816441	90816441	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr4:90816441G>A	ENST00000394980.1	+	2	638	c.319G>A	c.(319-321)Gaa>Aaa	p.E107K	MMRN1_ENST00000394981.1_Missense_Mutation_p.E73K|MMRN1_ENST00000264790.2_Missense_Mutation_p.E107K			Q13201	MMRN1_HUMAN	multimerin 1	107					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|liver(2)|lung(34)|ovary(5)|prostate(1)|skin(6)|stomach(1)|urinary_tract(2)	72		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		AGAGAAAGCAGAAGGAGTGGT	0.453000													8	53					0	0	1	0	0
SLC7A9	11136	broad.mit.edu	37	19	33355550	33355550	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:33355550C>A	ENST00000023064.4	-	3	411	c.220G>T	c.(220-222)Gtc>Ttc	p.V74F	SLC7A9_ENST00000590341.1_Missense_Mutation_p.V74F|SLC7A9_ENST00000587772.1_Missense_Mutation_p.V74F	NM_001126335.1|NM_001243036.1|NM_014270.4	NP_001119807.1|NP_001229965.1|NP_055085.1	P82251	BAT1_HUMAN	solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9	74					blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	integral to plasma membrane	L-cystine transmembrane transporter activity|neutral amino acid transmembrane transporter activity|peptide antigen binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	32	Esophageal squamous(110;0.137)				L-Cystine(DB00138)	GTCGCGAGGACCCCGCAAGCC	0.637000													6	76					0.000157383	0.000163849	1	1	0
RAD21	5885	broad.mit.edu	37	8	117862989	117862989	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr8:117862989C>T	ENST00000297338.2	-	12	1775	c.1488G>A	c.(1486-1488)caG>caA	p.Q496Q	RAD21_ENST00000523986.1_5'UTR|RAD21_ENST00000518055.1_Silent_p.Q41Q	NM_006265.2	NP_006256.1	O60216	RAD21_HUMAN	RAD21 homolog (S. pombe)	496	Pro-rich.				apoptosis|cell division|chromosome segregation|double-strand break repair|mitotic metaphase/anaphase transition|mitotic prometaphase|protein localization to chromatin|reciprocal meiotic recombination|regulation of transcription from RNA polymerase II promoter	chromosome, centromeric region|cohesin complex|nuclear chromosome|nucleoplasm	protein binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|skin(1)|stomach(1)	32	all_cancers(13;1.21e-21)|Lung NSC(37;0.000134)|Ovarian(258;0.0172)					GTATTTCCATCTGCTCTACCT	0.368000													9	79					0	0	1	0	0
CD82	3732	broad.mit.edu	37	11	44639760	44639760	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:44639760G>A	ENST00000227155.4	+	8	735	c.487G>A	c.(487-489)Gag>Aag	p.E163K	CD82_ENST00000530931.1_3'UTR|CD82_ENST00000342935.3_Missense_Mutation_p.E138K	NM_002231.3	NP_002222.1	P27701	CD82_HUMAN	CD82 molecule	163						integral to plasma membrane	protein binding			large_intestine(1)|ovary(1)	2						AGACAACGCTGAGCTCATGAA	0.602000													13	45					0	0	1	0	0
ADAM18	8749	broad.mit.edu	37	8	39486947	39486947	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr8:39486947G>C	ENST00000265707.5	+	7	622	c.577G>C	c.(577-579)Gaa>Caa	p.E193Q	ADAM18_ENST00000541111.1_5'UTR|ADAM18_ENST00000379866.1_Missense_Mutation_p.E193Q	NM_014237.2	NP_055052.1	Q9Y3Q7	ADA18_HUMAN	ADAM metallopeptidase domain 18	193	Peptidase M12B.				cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			NS(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(31)|ovary(1)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)	71		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			CATTATAGTGGAAAAAGCTTT	0.318000													18	196					0	0	1	0	0
HPS1	3257	broad.mit.edu	37	10	100190958	100190958	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr10:100190958C>T	ENST00000325103.6	-	7	831	c.598G>A	c.(598-600)Gag>Aag	p.E200K	HPS1_ENST00000467246.1_5'UTR|HPS1_ENST00000338546.5_Missense_Mutation_p.E200K|HPS1_ENST00000361490.4_Missense_Mutation_p.E200K	NM_000195.3	NP_000186.2	Q92902	HPS1_HUMAN	Hermansky-Pudlak syndrome 1	200					lysosome organization|response to stimulus|visual perception	cytoplasmic membrane-bounded vesicle|integral to plasma membrane|lysosome|membrane fraction|soluble fraction	protein dimerization activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(9)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	23		Colorectal(252;0.234)		Epithelial(162;3.87e-12)|all cancers(201;5.63e-10)		CCTCCCCGCTCGGGGCTGGTG	0.632000									Hermansky-Pudlak syndrome				3	11					0	0	1	0	0
FAM171B	165215	broad.mit.edu	37	2	187615976	187615976	+	Silent	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:187615976G>C	ENST00000304698.5	+	5	1043	c.840G>C	c.(838-840)ctG>ctC	p.L280L		NM_177454.3	NP_803237.3	Q6P995	F171B_HUMAN	family with sequence similarity 171, member B	280						integral to membrane	DNA binding			NS(1)|breast(6)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(22)|ovary(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						TTCTACGTCTGAATGATATAA	0.363000													21	88					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149481978	149481978	+	RNA	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:149481978C>G	ENST00000378016.2	+	0	2766							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CAGGGGCATTCTGCCCCAGGG	0.612000													24	42					0	0	1	0	0
TAT	6898	broad.mit.edu	37	16	71606217	71606217	+	Missense_Mutation	SNP	G	G	C	rs142154262		TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr16:71606217G>C	ENST00000355962.4	-	6	711	c.578C>G	c.(577-579)tCt>tGt	p.S193C	RP11-432I5.1_ENST00000561529.1_RNA	NM_000353.2	NP_000344.1	P17735	ATTY_HUMAN	tyrosine aminotransferase	193					2-oxoglutarate metabolic process|glutamate metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-tyrosine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(3)	29		Ovarian(137;0.125)		Kidney(780;0.0157)	L-Glutamic Acid(DB00142)|L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Pyridoxal Phosphate(DB00114)	AATTTCCCAAGATTTCTCTGG	0.398000													4	30					0	0	1	0	0
ATP5J2-PTCD1	100526740	broad.mit.edu	37	7	99057805	99057805	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:99057805C>T	ENST00000413834.1	-	2	47	c.25G>A	c.(25-27)Gac>Aac	p.D9N	ATP5J2_ENST00000544611.1_Missense_Mutation_p.D9N|PTCD1_ENST00000555673.1_Missense_Mutation_p.D9N|ATP5J2_ENST00000449683.1_Missense_Mutation_p.D19N|ATP5J2-PTCD1_ENST00000437572.1_Intron|ATP5J2_ENST00000394186.3_Missense_Mutation_p.D9N|ATP5J2_ENST00000488775.1_Missense_Mutation_p.D9N|ATP5J2_ENST00000292475.3_Missense_Mutation_p.D15N|ATP5J2_ENST00000466753.1_Intron|ATP5J2_ENST00000359832.4_Missense_Mutation_p.D15N			B4DJ38	B4DJ38_HUMAN		9																	AGTTTCTTGTCCTTCACTGGT	0.473000													24	105					0	0	1	0	0
SLC29A4	222962	broad.mit.edu	37	7	5336660	5336660	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:5336660C>T	ENST00000396872.3	+	7	874	c.713C>T	c.(712-714)tCg>tTg	p.S238L	SLC29A4_ENST00000297195.4_Missense_Mutation_p.S238L|SLC29A4_ENST00000406453.3_Missense_Mutation_p.S224L			Q7RTT9	S29A4_HUMAN	solute carrier family 29 (equilibrative nucleoside transporter), member 4						nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|integral to membrane	nucleoside transmembrane transporter activity			breast(1)|cervix(2)|kidney(7)|large_intestine(1)|liver(1)|lung(7)|urinary_tract(1)	20		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0903)|OV - Ovarian serous cystadenocarcinoma(56;2.65e-15)		TTCCTGGTGTCGGTGGCGCTG	0.662000													6	45					0	0	1	0	0
EWSR1	2130	broad.mit.edu	37	22	29669816	29669816	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr22:29669816G>A	ENST00000397938.2	+	4	508	c.189G>A	c.(187-189)caG>caA	p.Q63Q	EWSR1_ENST00000332050.6_Silent_p.Q63Q|EWSR1_ENST00000414183.2_Silent_p.Q63Q|EWSR1_ENST00000406548.1_Silent_p.Q63Q|EWSR1_ENST00000331029.7_Silent_p.Q63Q|EWSR1_ENST00000333395.6_Silent_p.Q63Q|EWSR1_ENST00000332035.6_Silent_p.Q63Q	NM_001163285.1|NM_001163286.1|NM_005243.3|NM_013986.3	NP_001156757.1|NP_001156758.1|NP_005234.1|NP_053733.2	Q01844	EWS_HUMAN	EWS RNA-binding protein 1	63	31 X approximate tandem repeats.|EAD (Gln/Pro/Thr-rich).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	calmodulin binding|nucleotide binding|RNA binding|zinc ion binding		EWSR1/ATF1(347)|EWSR1/POU5F1(10)|EWSR1/PBX1(3)|EWSR1/DDIT3(45)|EWSR1/FEV(11)|EWSR1/CREB1(44)|EWSR1/SMARCA5(2)|EWSR1/ETV4(6)|EWSR1/ERG(178)|EWSR1/ZNF384(4)|EWSR1/ETV1(7)|EWSR1/FLI1(2569)|EWSR1/NR4A3(146)|EWSR1/SP3(3)|EWSR1/PATZ1(2)|EWSR1/WT1(234)|EWSR1/NFATC2(9)	breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|liver(1)|lung(6)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						CCTATGGGCAGACCGCCTATG	0.507000			T	"""FLI1, ERG, ZNF278, NR4A3, FEV, ATF1, ETV1, ETV4, WT1, ZNF384, CREB1, POU5F1,  PBX1"""	"""Ewing sarcoma,  desmoplastic small round cell tumor , ALL, clear cell sarcoma, sarcoma, myoepithelioma"""								21	38					0	0	1	0	0
ABCA6	23460	broad.mit.edu	37	17	67092856	67092856	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr17:67092856G>T	ENST00000284425.2	-	24	3381	c.3207C>A	c.(3205-3207)ttC>ttA	p.F1069L	ABCA6_ENST00000446604.2_5'UTR	NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	1069					transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					GAATTAAAATGAAGAAGCTGA	0.363000													11	36					5.50884e-06	5.76632e-06	1	1	0
HIST1H2BC	8347	broad.mit.edu	37	6	26123970	26123970	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:26123970T>C	ENST00000314332.5	-	1	168	c.163A>G	c.(163-165)Atc>Gtc	p.I55V	HIST1H2BC_ENST00000396984.1_Missense_Mutation_p.I55V			P62807	H2B1C_HUMAN	histone cluster 1, H2bc	55					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)	16						TTGGAAGAGATGCCAGTGTCG	0.542000													29	124					0	0	1	0	0
CBLN2	147381	broad.mit.edu	37	18	70209071	70209071	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr18:70209071T>A	ENST00000269503.4	-	3	1098	c.325A>T	c.(325-327)Agc>Tgc	p.S109C	CBLN2_ENST00000585159.1_Missense_Mutation_p.S109C|CBLN2_ENST00000581073.1_Intron|CBLN2_ENST00000583651.1_Intron|CBLN2_ENST00000584764.1_Intron	NM_182511.3	NP_872317.1	Q8IUK8	CBLN2_HUMAN	cerebellin 2 precursor	109	C1q.					integral to membrane				endometrium(2)|lung(15)	17		Esophageal squamous(42;0.131)				GTGCGGTTGCTCATCTCGGAC	0.721000													5	6					0	0	1	0	0
AP4M1	9179	broad.mit.edu	37	7	99704427	99704427	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:99704427C>T	ENST00000429084.1	+	15	1463	c.1305C>T	c.(1303-1305)ttC>ttT	p.F435F	AP4M1_ENST00000421755.1_Silent_p.F428F|AP4M1_ENST00000359593.4_Silent_p.F428F|AP4M1_ENST00000422582.1_Silent_p.F300F			O00189	AP4M1_HUMAN	adaptor-related protein complex 4, mu 1 subunit	428	MHD.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|coated pit|Golgi trans cisterna	transporter activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)	17	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GGCTGGCCTTCAGGCCATGCG	0.642000													11	28					0	0	1	0	0
SNX31	169166	broad.mit.edu	37	8	101608876	101608876	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr8:101608876G>A	ENST00000311812.2	-	10	1119	c.969C>T	c.(967-969)gtC>gtT	p.V323V	SNX31_ENST00000428383.2_Silent_p.V224V|SNX31_ENST00000519521.1_5'UTR	NM_152628.3	NP_689841.3	Q8N9S9	SNX31_HUMAN	sorting nexin 31	323					cell communication|protein transport		phosphatidylinositol binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|skin(3)|urinary_tract(1)	26	all_cancers(14;4.01e-05)|all_epithelial(15;1.26e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;1.21e-11)|all cancers(13;2.62e-09)|OV - Ovarian serous cystadenocarcinoma(57;3.22e-06)|STAD - Stomach adenocarcinoma(118;0.206)			CAAGGAAAGTGACCTGCCAGC	0.488000													17	31					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10212682	10212682	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr17:10212682G>A	ENST00000418404.3	-	34	5201	c.5038C>T	c.(5038-5040)Cgc>Tgc	p.R1680C	MYH13_ENST00000252172.4_Missense_Mutation_p.R1680C|RP11-401O9.4_ENST00000609088.1_RNA			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	1680					muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						CCATTCCTGCGCTCCACGATG	0.642000													3	21					0	0	1	0	0
CTAGE5	4253	broad.mit.edu	37	14	39782546	39782546	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr14:39782546A>T	ENST00000553728.1	+	18	3014	c.2801A>T	c.(2800-2802)aAa>aTa	p.K934I	CTAGE5_ENST00000396165.4_Missense_Mutation_p.K370I|RP11-407N17.3_ENST00000603904.1_Missense_Mutation_p.K370I|CTAGE5_ENST00000396158.2_Missense_Mutation_p.K404I|CTAGE5_ENST00000280083.3_Missense_Mutation_p.K399I|CTAGE5_ENST00000557038.1_Missense_Mutation_p.K319I|CTAGE5_ENST00000341749.3_Missense_Mutation_p.K387I|CTAGE5_ENST00000348007.3_Missense_Mutation_p.K399I|CTAGE5_ENST00000341502.5_Missense_Mutation_p.K399I|CTAGE5_ENST00000553352.1_Missense_Mutation_p.K370I|CTAGE5_ENST00000556148.1_Missense_Mutation_p.K324I																							TTTTTAAGGAAATTAACAGTA	0.303000													5	34					0	0	1	0	0
CMA1	1215	broad.mit.edu	37	14	24977459	24977459	+	Translation_Start_Site	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr14:24977459C>A	ENST00000250378.3	-	0	12				CMA1_ENST00000206446.4_De_novo_Start_InFrame|RP11-80A15.1_ENST00000555109.1_Silent_p.A87A	NM_001836.3	NP_001827.1	P23946	CMA1_HUMAN	chymase 1, mast cell						interleukin-1 beta biosynthetic process|proteolysis	extracellular region	serine-type endopeptidase activity			kidney(1)|lung(8)|pancreas(1)|prostate(1)	11				GBM - Glioblastoma multiforme(265;0.0271)		GAGAGGCTGCCTGAGCAAATG	0.527000													3	13					0.004672	0.00476603	1	1	0
TMC1	117531	broad.mit.edu	37	9	75407236	75407236	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr9:75407236C>G	ENST00000297784.5	+	17	2074	c.1534C>G	c.(1534-1536)Cga>Gga	p.R512G	TMC1_ENST00000486417.1_3'UTR|TMC1_ENST00000340019.3_Missense_Mutation_p.R512G|TMC1_ENST00000396237.3_Missense_Mutation_p.R512G	NM_138691.2	NP_619636.2	Q8TDI8	TMC1_HUMAN	transmembrane channel-like 1	512					sensory perception of sound	integral to membrane				NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(21)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	36						AGATGTACCTCGAGGACCTTG	0.423000													38	164					0	0	1	0	0
BEST4	266675	broad.mit.edu	37	1	45253367	45253367	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:45253367G>A	ENST00000372207.3	-	1	10	c.11C>T	c.(10-12)tCa>tTa	p.S4L		NM_153274.2	NP_695006.1	Q8NFU0	BEST4_HUMAN	bestrophin 4	4						chloride channel complex|plasma membrane	chloride channel activity			large_intestine(1)|lung(4)|ovary(1)|skin(1)	7	Acute lymphoblastic leukemia(166;0.155)					GAGAGTGTATGAAACCGTCAT	0.577000													9	39					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8517918	8517918	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr9:8517918T>G	ENST00000381196.4	-	18	2016	c.1473A>C	c.(1471-1473)aaA>aaC	p.K491N	PTPRD_ENST00000540109.1_Missense_Mutation_p.K491N|PTPRD_ENST00000397617.3_Missense_Mutation_p.K481N|PTPRD_ENST00000356435.5_Missense_Mutation_p.K491N|PTPRD_ENST00000397606.3_Missense_Mutation_p.K481N|PTPRD_ENST00000537002.1_Missense_Mutation_p.K488N|PTPRD_ENST00000360074.4_Missense_Mutation_p.K478N|PTPRD_ENST00000358503.5_Missense_Mutation_p.K478N|PTPRD_ENST00000397611.3_Missense_Mutation_p.K488N|PTPRD_ENST00000355233.5_Missense_Mutation_p.K491N|PTPRD_ENST00000486161.1_Missense_Mutation_p.K491N	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	491	Fibronectin type-III 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		AAGCCAGGACTTTGACAGAAT	0.438000										TSP Lung(15;0.13)			10	46					0	0	1	0	0
CHN2	1124	broad.mit.edu	37	7	29440302	29440302	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:29440302C>G	ENST00000222792.6	+	6	964	c.434C>G	c.(433-435)tCa>tGa	p.S145*	CHN2_ENST00000546235.1_Nonsense_Mutation_p.S130*|CHN2_ENST00000539389.1_Intron|CHN2_ENST00000435288.2_Intron|CHN2_ENST00000495789.2_Nonsense_Mutation_p.S158*|CHN2_ENST00000539406.1_Nonsense_Mutation_p.S220*	NM_004067.2	NP_004058.1	P52757	CHIO_HUMAN	chimerin 2	145					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|membrane	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			breast(2)|endometrium(3)|large_intestine(2)|lung(12)|ovary(2)|urinary_tract(2)	23						GAGTACATTTCAAAAATGACA	0.408000													8	45					0	0	1	0	0
TMEM241	85019	broad.mit.edu	37	18	20964995	20964995	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr18:20964995C>G	ENST00000383233.3	-	5	368	c.316G>C	c.(316-318)Gaa>Caa	p.E106Q	TMEM241_ENST00000542162.1_Missense_Mutation_p.E106Q|TMEM241_ENST00000450466.2_5'UTR|TMEM241_ENST00000399707.1_Missense_Mutation_p.E80Q	NM_032933.4	NP_116322.3	Q24JQ0	CR045_HUMAN	transmembrane protein 241	106						integral to membrane											ATGATAACTTCAGCTACATTA	0.333000													6	35					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167675327	167675327	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr5:167675327G>C	ENST00000519204.1	+	26	7138	c.7020G>C	c.(7018-7020)aaG>aaC	p.K2340N	TENM2_ENST00000520394.1_Missense_Mutation_p.K2222N|TENM2_ENST00000403607.2_Missense_Mutation_p.K2285N|TENM2_ENST00000518659.1_Missense_Mutation_p.K2461N|TENM2_ENST00000545108.1_Missense_Mutation_p.K2460N					teneurin transmembrane protein 2																		ATATGTTCAAGAGCAACAATC	0.517000													7	18					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151948040	151948040	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:151948040C>T	ENST00000355193.2	-	12	1851	c.1633G>A	c.(1633-1635)Gaa>Aaa	p.E545K	KMT2C_ENST00000262189.6_Missense_Mutation_p.E545K					lysine (K)-specific methyltransferase 2C																		ACTTCCATTTCATTGTTATAA	0.343000													10	54					0	0	1	0	0
CORIN	10699	broad.mit.edu	37	4	47676441	47676441	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr4:47676441G>A	ENST00000273857.4	-	10	1325	c.1326C>T	c.(1324-1326)ctC>ctT	p.L442L	CORIN_ENST00000508498.1_Silent_p.L303L|CORIN_ENST00000504584.1_Silent_p.L405L|CORIN_ENST00000502252.1_Silent_p.L375L|CORIN_ENST00000505909.1_Silent_p.L405L	NM_006587.2	NP_006578.2	Q9Y5Q5	CORIN_HUMAN	corin, serine peptidase	442					peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						TCGGGTCACAGAGAGAGCTAC	0.448000													34	42					0	0	1	0	0
LIMD1	8994	broad.mit.edu	37	3	45637258	45637258	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:45637258C>T	ENST00000273317.4	+	1	908	c.887C>T	c.(886-888)tCt>tTt	p.S296F	LIMD1_ENST00000465039.1_Intron|LIMD1_ENST00000440097.1_Missense_Mutation_p.S296F	NM_014240.2	NP_055055.1	Q9UGP4	LIMD1_HUMAN	LIM domains containing 1	296					cytoplasmic mRNA processing body assembly|gene silencing by miRNA|multicellular organismal development|negative regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasmic mRNA processing body|nucleus|RNA-induced silencing complex	protein binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)	10				BRCA - Breast invasive adenocarcinoma(193;0.011)|KIRC - Kidney renal clear cell carcinoma(197;0.0264)|Kidney(197;0.0315)		AGGACCCCTTCTGTGTCAGCA	0.632000													15	54					0	0	1	0	0
C3orf56	285311	broad.mit.edu	37	3	126916019	126916019	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:126916019C>T	ENST00000398112.1	+	2	731	c.491C>T	c.(490-492)tCa>tTa	p.S164L		NM_001007534.2	NP_001007535.1			chromosome 3 open reading frame 56											breast(1)|endometrium(2)|kidney(1)|lung(5)	9				GBM - Glioblastoma multiforme(114;0.142)		CCAGCCAGCTCAGCCCCCAGG	0.627000													17	48					0	0	1	0	0
USP32	84669	broad.mit.edu	37	17	58300841	58300841	+	Silent	SNP	C	C	T	rs138712503		TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr17:58300841C>T	ENST00000300896.4	-	14	1733	c.1539G>A	c.(1537-1539)ttG>ttA	p.L513L	USP32_ENST00000592339.1_Silent_p.L183L	NM_032582.3	NP_115971.2	Q8NFA0	UBP32_HUMAN	ubiquitin specific peptidase 32	513	DUSP.				protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(5)|endometrium(5)|kidney(4)|large_intestine(12)|liver(1)|lung(24)|pancreas(1)|prostate(3)|skin(3)|urinary_tract(1)	62	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			TAAGGTGCAACAAAATATTCC	0.393000													16	101					0	0	1	0	0
ABCF2	10061	broad.mit.edu	37	7	150921105	150921105	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:150921105C>T	ENST00000287844.2	-	4	572	c.463G>A	c.(463-465)Gac>Aac	p.D155N	ABCF2_ENST00000222388.2_Missense_Mutation_p.D155N	NM_007189.1	NP_009120.1	Q9UG63	ABCF2_HUMAN	ATP-binding cassette, sub-family F (GCN20), member 2	155	ABC transporter 1.					ATP-binding cassette (ABC) transporter complex|mitochondrial envelope	ATP binding|ATPase activity|transporter activity			breast(1)|central_nervous_system(1)|large_intestine(4)|lung(15)|ovary(1)|skin(2)	24			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGTGTCTTGTCACTAGGGGGC	0.557000													14	30					0	0	1	0	0
TBC1D8B	54885	broad.mit.edu	37	X	106065249	106065249	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:106065249G>C	ENST00000357242.5	+	4	577	c.403G>C	c.(403-405)Gat>Cat	p.D135H	TBC1D8B_ENST00000310452.2_Missense_Mutation_p.D135H|TBC1D8B_ENST00000276175.3_Missense_Mutation_p.D135H|TBC1D8B_ENST00000481617.2_Missense_Mutation_p.D135H	NM_017752.2	NP_060222.2	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	135						intracellular	calcium ion binding|Rab GTPase activator activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|liver(4)|lung(15)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						TGCAAAAGAAGATGATCCTGA	0.318000													31	54					0	0	1	0	0
RWDD4	201965	broad.mit.edu	37	4	184577047	184577047	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr4:184577047G>C	ENST00000326397.5	-	2	364	c.92C>G	c.(91-93)tCt>tGt	p.S31C	RWDD4_ENST00000327570.9_Missense_Mutation_p.S31C|RWDD4_ENST00000512740.1_Intron|RWDD4_ENST00000510968.1_Intron	NM_152682.2	NP_689895.2	Q6NW29	RWDD4_HUMAN	RWD domain containing 4	31	RWD.									large_intestine(2)|lung(4)|ovary(1)|prostate(1)	8						ATATTGAAAAGAAACTGGACT	0.318000													23	86					0	0	1	0	0
FN1	2335	broad.mit.edu	37	2	216274681	216274681	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:216274681T>G	ENST00000354785.4	-	14	2467	c.2098A>C	c.(2098-2100)Acc>Ccc	p.T700P	FN1_ENST00000432072.2_Missense_Mutation_p.T700P|FN1_ENST00000357009.2_Missense_Mutation_p.T700P|FN1_ENST00000359671.1_Missense_Mutation_p.T700P|FN1_ENST00000346544.3_Missense_Mutation_p.T700P|FN1_ENST00000345488.5_Missense_Mutation_p.T700P|FN1_ENST00000323926.6_Missense_Mutation_p.T700P|FN1_ENST00000357867.4_Missense_Mutation_p.T700P|FN1_ENST00000446046.1_Missense_Mutation_p.T700P|FN1_ENST00000443816.1_Missense_Mutation_p.T700P|FN1_ENST00000421182.1_Missense_Mutation_p.T700P|FN1_ENST00000356005.4_Missense_Mutation_p.T700P|FN1_ENST00000336916.4_Missense_Mutation_p.T700P			P02751	FINC_HUMAN	fibronectin 1	700					acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding		FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTGGTGCTGGTGGTGGTGAAG	0.562000													24	98					0	0	1	0	0
VASN	114990	broad.mit.edu	37	16	4432202	4432202	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr16:4432202G>C	ENST00000304735.3	+	2	1479	c.1324G>C	c.(1324-1326)Gag>Cag	p.E442Q	CORO7_ENST00000251166.4_Intron|CORO7_ENST00000539968.1_Intron|CORO7_ENST00000574025.1_Intron|CORO7-PAM16_ENST00000572467.1_Intron|CORO7_ENST00000423908.2_Intron|CORO7_ENST00000537233.2_Intron	NM_138440.2	NP_612449.2	Q6EMK4	VASN_HUMAN	vasorin	442	EGF-like.					extracellular region|integral to membrane				breast(1)|lung(3)|prostate(1)|skin(1)	6						CCTGTACTGTGAGAGCCAGAT	0.692000													3	1					0	0	1	0	0
C1orf52	148423	broad.mit.edu	37	1	85725229	85725229	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:85725229C>T	ENST00000471115.1	-	1	96	c.88G>A	c.(88-90)Gag>Aag	p.E30K	C1orf52_ENST00000344356.5_Missense_Mutation_p.E30K|C1orf52_ENST00000294661.4_5'UTR	NM_198077.3	NP_932343.1	Q8N6N3	CA052_HUMAN	chromosome 1 open reading frame 52	30										endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)	10				all cancers(265;0.0105)|Epithelial(280;0.0293)		TCCTCCGGCTCGATGTTATCC	0.647000											OREG0013580	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	9					0	0	1	0	0
EPHX3	79852	broad.mit.edu	37	19	15338883	15338883	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:15338883G>T	ENST00000221730.3	-	5	865	c.645C>A	c.(643-645)ttC>ttA	p.F215L	EPHX3_ENST00000435261.1_Missense_Mutation_p.F215L|EPHX3_ENST00000602233.1_Missense_Mutation_p.F215L	NM_024794.2	NP_079070.1	Q9H6B9	EPHX3_HUMAN	epoxide hydrolase 3	215						extracellular region	hydrolase activity			endometrium(1)|large_intestine(1)|lung(3)|pancreas(1)|skin(1)	7						GGGAACGGAAGAACTGGCTGA	0.577000													7	16					0.00307968	0.00315839	1	1	0
KIF6	221458	broad.mit.edu	37	6	39325103	39325103	+	Silent	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:39325103G>C	ENST00000287152.7	-	19	2224	c.2130C>G	c.(2128-2130)ctC>ctG	p.L710L	KIF6_ENST00000229913.5_Silent_p.L161L|KIF6_ENST00000538893.1_Silent_p.L654L|KIF6_ENST00000373216.3_Silent_p.L710L|KIF6_ENST00000373213.4_Silent_p.L549L|KIF6_ENST00000541946.1_Silent_p.L161L|KIF6_ENST00000373215.3_Silent_p.L693L|KIF6_ENST00000394362.1_Silent_p.L161L	NM_145027.4	NP_659464.3	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	710					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(16)|large_intestine(8)|lung(15)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	52						CAGATGTCTGGAGAAATGGCT	0.473000													14	62					0	0	1	0	0
CPE	1363	broad.mit.edu	37	4	166405672	166405672	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr4:166405672C>T	ENST00000402744.4	+	5	1169	c.889C>T	c.(889-891)Cgg>Tgg	p.R297W		NM_001873.2	NP_001864.1	P16870	CBPE_HUMAN	carboxypeptidase E	297			R -> Q (in a colorectal cancer sample; somatic mutation).		cardiac left ventricle morphogenesis|neuropeptide signaling pathway|protein modification process	extracellular region|nucleus|plasma membrane	metallocarboxypeptidase activity|protein binding|zinc ion binding			endometrium(2)|large_intestine(10)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	26	all_hematologic(180;0.221)	Prostate(90;0.0962)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.137)	Glucagon recombinant(DB00040)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TGACCCCAATCGGCCACCATG	0.532000													120	129					0	0	1	0	0
ERCC6L	54821	broad.mit.edu	37	X	71427455	71427455	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:71427455C>G	ENST00000373657.1	-	3	1395	c.793G>C	c.(793-795)Gat>Cat	p.D265H	ERCC6L_ENST00000334463.3_Missense_Mutation_p.D388H|PIN4_ENST00000423432.2_Intron			Q2NKX8	ERC6L_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6-like	388	Helicase ATP-binding.				cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol	ATP binding|DNA binding|helicase activity|protein binding			breast(2)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(9)|lung(9)|ovary(3)|skin(1)	38	Renal(35;0.156)					TTGATATGATCTAAAGACACA	0.418000													39	60					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	81675174	81675174	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:81675174C>G	ENST00000550584.2	-	26	3369	c.3074G>C	c.(3073-3075)gGa>gCa	p.G1025A	PPFIA2_ENST00000550359.2_Missense_Mutation_p.G872A|PPFIA2_ENST00000443686.3_Missense_Mutation_p.G920A|PPFIA2_ENST00000552948.1_Missense_Mutation_p.G1004A|PPFIA2_ENST00000549396.1_Missense_Mutation_p.G1025A|PPFIA2_ENST00000545296.2_Intron|PPFIA2_ENST00000541017.1_Missense_Mutation_p.G211A|PPFIA2_ENST00000549325.1_Missense_Mutation_p.G1010A|PPFIA2_ENST00000548586.1_Missense_Mutation_p.G1019A|PPFIA2_ENST00000407050.4_Missense_Mutation_p.G924A|RP11-121G22.3_ENST00000549161.1_lincRNA|PPFIA2_ENST00000333447.7_Missense_Mutation_p.G1010A|PPFIA2_ENST00000541570.2_Missense_Mutation_p.G561A	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	924										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						CCATTCATTTCCAATCCACTC	0.378000													6	48					0	0	1	0	0
LIAS	11019	broad.mit.edu	37	4	39471699	39471699	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr4:39471699G>C	ENST00000261434.3	+	8	916	c.798G>C	c.(796-798)aaG>aaC	p.K266N	LIAS_ENST00000513731.1_Missense_Mutation_p.K136N|LIAS_ENST00000381846.1_Missense_Mutation_p.K223N|LIAS_ENST00000340169.2_Missense_Mutation_p.K266N	NM_006859.2	NP_006850.2	O43766	LIAS_HUMAN	lipoic acid synthetase	266					inflammatory response|response to lipopolysaccharide|response to oxidative stress	mitochondrion	4 iron, 4 sulfur cluster binding|lipoate synthase activity|metal ion binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(2)|ovary(2)	12					Lipoic Acid(DB00166)	AACATGCCAAGAAGGTTCAGC	0.393000													11	29					0	0	1	0	0
TSC22D3	1831	broad.mit.edu	37	X	106957959	106957959	+	Silent	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:106957959C>G	ENST00000372383.4	-	3	760	c.393G>C	c.(391-393)ctG>ctC	p.L131L	TSC22D3_ENST00000372397.2_Silent_p.L65L|TSC22D3_ENST00000506081.1_Silent_p.L131L|TSC22D3_ENST00000514426.1_Silent_p.L63L|TSC22D3_ENST00000372390.4_Silent_p.L8L|TSC22D3_ENST00000315660.4_Silent_p.L131L|TSC22D3_ENST00000372382.4_Silent_p.L41L|TSC22D3_ENST00000372384.2_Silent_p.L131L	NM_198057.2	NP_932174.1	Q99576	T22D3_HUMAN	TSC22 domain family, member 3	65							sequence-specific DNA binding transcription factor activity			breast(1)|large_intestine(2)|lung(3)	6						CAGCATACATCAGATGATTCT	0.512000													14	86					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39888501	39888501	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:39888501G>C	ENST00000564288.1	+	60	16855	c.16078G>C	c.(16078-16080)Gag>Cag	p.E5360Q	MACF1_ENST00000567887.1_Missense_Mutation_p.E5397Q|MACF1_ENST00000289893.4_Missense_Mutation_p.E3800Q|MACF1_ENST00000545844.1_Missense_Mutation_p.E3298Q|MACF1_ENST00000361689.2_Missense_Mutation_p.E3298Q|MACF1_ENST00000372915.3_Missense_Mutation_p.E5365Q|MACF1_ENST00000539005.1_Missense_Mutation_p.E3277Q|MACF1_ENST00000317713.7_Missense_Mutation_p.E3298Q			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	5365					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AGATACCGAGGAGCTCATAGC	0.473000													25	37					0	0	1	0	0
FCRL4	83417	broad.mit.edu	37	1	157556119	157556119	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:157556119C>A	ENST00000271532.1	-	6	1109	c.974G>T	c.(973-975)cGa>cTa	p.R325L	FCRL4_ENST00000448509.2_5'UTR	NM_031282.2	NP_112572.1	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4	325	Ig-like C2-type 4.					integral to membrane|plasma membrane	receptor activity			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(5)|lung(20)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	40	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				CATGTCCTCTCGGTGCCAGGA	0.607000													4	99					0.150653	0.15144	1	1	0
STK3	6788	broad.mit.edu	37	8	99718791	99718791	+	Silent	SNP	T	T	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr8:99718791T>A	ENST00000523601.1	-	8	1071	c.672A>T	c.(670-672)atA>atT	p.I224I	STK3_ENST00000419617.2_Silent_p.I196I	NM_001256312.1	NP_001243241.1	Q13188	STK3_HUMAN	serine/threonine kinase 3	196	Protein kinase.				apoptosis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of apoptosis	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein dimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	17	Breast(36;2.4e-06)	Breast(495;0.106)	OV - Ovarian serous cystadenocarcinoma(57;0.0382)	KIRC - Kidney renal clear cell carcinoma(542;9.44e-06)		AGTTATAGCCTATTTCTTGAA	0.408000													39	87					0	0	1	0	0
NLGN3	54413	broad.mit.edu	37	X	70367798	70367798	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:70367798G>A	ENST00000374051.3	+	2	521	c.199G>A	c.(199-201)Gac>Aac	p.D67N	NLGN3_ENST00000358741.3_Missense_Mutation_p.D67N|NLGN3_ENST00000536169.1_Missense_Mutation_p.D67N	NM_018977.3	NP_061850.2	Q9NZ94	NLGN3_HUMAN	neuroligin 3	67					neuron cell-cell adhesion|positive regulation of synaptogenesis|receptor-mediated endocytosis|social behavior|synapse assembly	cell surface|endocytic vesicle|integral to plasma membrane|synapse	neurexin binding|receptor activity			biliary_tract(1)|breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(10)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	37	Renal(35;0.156)					GGGGCCTGTGGACCAATACCT	0.647000													4	20					0	0	1	0	0
CAV3	859	broad.mit.edu	37	3	8787493	8787493	+	Silent	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:8787493C>G	ENST00000343849.2	+	2	473	c.396C>G	c.(394-396)ctC>ctG	p.L132L	CAV3_ENST00000397368.2_Silent_p.L132L|CAV3_ENST00000472766.1_Intron	NM_001234.4|NM_033337.2	NP_001225.1|NP_203123.1	P56539	CAV3_HUMAN	caveolin 3	132					cell growth|elevation of cytosolic calcium ion concentration|muscle organ development|negative regulation of cardiac muscle hypertrophy|negative regulation of cell size|negative regulation of MAP kinase activity|negative regulation of sarcomere organization|positive regulation of microtubule polymerization|regulation of skeletal muscle contraction|regulation of ventricular cardiomyocyte membrane repolarization|T-tubule organization	caveola|dystrophin-associated glycoprotein complex|Golgi membrane|neuromuscular junction|T-tubule	protein C-terminus binding|protein complex binding|protein complex scaffold|sodium channel regulator activity			breast(1)|kidney(2)|large_intestine(4)|lung(3)|prostate(1)	11						GCAACCCACTCTTCGCGGCCC	0.607000													24	66					0	0	1	0	0
NXF4	55999	broad.mit.edu	37	X	101826197	101826197	+	RNA	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:101826197C>G	ENST00000360035.2	+	0	3337					NR_002216.1															endometrium(2)|lung(8)	10						TTTCACTATTCTCCAGGTGAG	0.488000													6	14					0	0	1	0	0
PLCXD3	345557	broad.mit.edu	37	5	41382448	41382448	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr5:41382448G>A	ENST00000377801.3	-	2	366	c.292C>T	c.(292-294)Cga>Tga	p.R98*	PLCXD3_ENST00000328457.3_Nonsense_Mutation_p.R98*			Q63HM9	PLCX3_HUMAN	phosphatidylinositol-specific phospholipase C, X domain containing 3	98	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity	p.R98*(1)		central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37						GTGGAAATTCGAAGATCAAAA	0.443000													23	63					0	0	1	0	0
CRHBP	1393	broad.mit.edu	37	5	76259175	76259175	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr5:76259175C>T	ENST00000274368.4	+	6	1123	c.701C>T	c.(700-702)tCa>tTa	p.S234L	CRHBP_ENST00000514258.1_3'UTR	NM_001882.3	NP_001873.2	P24387	CRHBP_HUMAN	corticotropin releasing hormone binding protein	234					female pregnancy|learning or memory|signal transduction	soluble fraction				kidney(3)|large_intestine(4)|lung(6)|prostate(1)|skin(2)	16		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-51)|Epithelial(54;8.79e-46)|all cancers(79;2.49e-41)		TAGAAATCCTCAGCAGGTTGC	0.463000													20	84					0	0	1	0	0
KIAA0232	9778	broad.mit.edu	37	4	6862709	6862709	+	Silent	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr4:6862709C>G	ENST00000307659.5	+	7	1055	c.600C>G	c.(598-600)gtC>gtG	p.V200V	KIAA0232_ENST00000425103.1_Silent_p.V200V	NM_014743.2	NP_055558.2	Q92628	K0232_HUMAN	KIAA0232	200							ATP binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(12)|ovary(2)|prostate(4)|skin(1)|urinary_tract(1)	41						AGTCTAAAGTCTGTTCTTACT	0.438000													14	71					0	0	1	0	0
MCTP1	79772	broad.mit.edu	37	5	94208915	94208915	+	Silent	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr5:94208915C>G	ENST00000515393.1	-	13	1964	c.1965G>C	c.(1963-1965)ctG>ctC	p.L655L	MCTP1_ENST00000505078.1_Silent_p.L171L|MCTP1_ENST00000429576.2_Silent_p.L388L|MCTP1_ENST00000312216.8_Silent_p.L434L|MCTP1_ENST00000505208.1_Silent_p.L434L	NM_024717.4	NP_078993.4	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1	655	C2 3.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(3)|large_intestine(13)|liver(2)|lung(13)|ovary(2)|skin(4)|stomach(2)|urinary_tract(1)	41		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		TATCGTTGTTCAGTTCTACCA	0.373000													18	28					0	0	1	0	0
SDC2	6383	broad.mit.edu	37	8	97620648	97620648	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr8:97620648A>G	ENST00000302190.4	+	4	1313	c.392A>G	c.(391-393)tAt>tGt	p.Y131C	SDC2_ENST00000519914.1_Missense_Mutation_p.Y102C|SDC2_ENST00000518385.1_Missense_Mutation_p.Y95C|SDC2_ENST00000522911.1_Missense_Mutation_p.Y102C	NM_002998.3	NP_002989.2	P34741	SDC2_HUMAN	syndecan 2	131						integral to plasma membrane	cytoskeletal protein binding|PDZ domain binding			breast(1)|cervix(1)|large_intestine(5)|lung(4)|ovary(2)|prostate(1)|stomach(2)	16	Breast(36;3.41e-05)				Sargramostim(DB00020)	ACAAATGTGTATACTGAGAAA	0.483000													12	39					0	0	1	0	0
KREMEN1	83999	broad.mit.edu	37	22	29533341	29533341	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr22:29533341G>A	ENST00000400338.2	+	6	696	c.643G>A	c.(643-645)Gcc>Acc	p.A215T	KREMEN1_ENST00000327813.5_Missense_Mutation_p.A215T|KREMEN1_ENST00000400335.4_Missense_Mutation_p.A215T|KREMEN1_ENST00000407188.1_Missense_Mutation_p.A213T			Q96MU8	KREM1_HUMAN	kringle containing transmembrane protein 1	213	CUB.				cell communication|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane|membrane fraction	protein binding			breast(1)|endometrium(3)|large_intestine(2)|lung(8)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)	20						TCTCGTGGGCGCCTGCGGTGG	0.592000													12	73					0	0	1	0	0
BPIFB6	128859	broad.mit.edu	37	20	31628062	31628062	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr20:31628062C>A	ENST00000349552.1	+	11	1080	c.1080C>A	c.(1078-1080)ttC>ttA	p.F360L		NM_174897.2	NP_777557.1	Q8NFQ5	BPIL3_HUMAN	BPI fold containing family B, member 6	360						extracellular region	lipid binding										GCCAGCACTTCAATCTGAAGG	0.587000													5	44					0.000602214	0.000620913	1	1	0
CHCHD5	84269	broad.mit.edu	37	2	113343940	113343940	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:113343940G>C	ENST00000409719.1	+	3	360	c.307G>C	c.(307-309)Gag>Cag	p.E103Q	CHCHD5_ENST00000489052.1_3'UTR|CHCHD5_ENST00000324913.5_Missense_Mutation_p.E103Q			Q9BSY4	CHCH5_HUMAN	coiled-coil-helix-coiled-coil-helix domain containing 5	103										NS(1)|endometrium(1)|large_intestine(4)|urinary_tract(1)	7						TGCAACTGTGGAGGTAAGAGG	0.562000													8	37					0	0	1	0	0
ARHGEF26	26084	broad.mit.edu	37	3	153840609	153840609	+	Silent	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:153840609C>G	ENST00000356448.4	+	2	1112	c.828C>G	c.(826-828)ctC>ctG	p.L276L	ARHGEF26_ENST00000465817.1_Silent_p.L276L|ARHGEF26_ENST00000465093.1_Silent_p.L276L	NM_001251962.1	NP_001238891.1	Q96DR7	ARHGQ_HUMAN	Rho guanine nucleotide exchange factor (GEF) 26	276					regulation of Rho protein signal transduction	intracellular|ruffle	Rho guanyl-nucleotide exchange factor activity			endometrium(4)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|pancreas(1)|urinary_tract(1)	23						AGAGACTCCTCAAGGTGCGCA	0.542000													3	12					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24878189	24878189	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr14:24878189C>G	ENST00000382554.3	+	4	1507	c.1189C>G	c.(1189-1191)Ctg>Gtg	p.L397V		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	397					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						GCAGAGACCTCTGGGCCCCAT	0.547000													4	11					0	0	1	0	0
GATA3-AS1	399717	broad.mit.edu	37	10	8092836	8092836	+	RNA	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr10:8092836C>T	ENST00000355358.1	-	0	1790					NR_024256.1																						TTTAGGACTTCGACCCCGGGG	0.672000													5	4					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	131844337	131844337	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:131844337T>C	ENST00000359827.3	-	25	5517	c.4555A>G	c.(4555-4557)Atc>Gtc	p.I1519V	PLXNA4_ENST00000321063.4_Missense_Mutation_p.I1519V			Q9HCM2	PLXA4_HUMAN	plexin A4	1519						integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						CAGTTGAGGATCTTTACTGGG	0.532000													42	165					0	0	1	0	0
UBE2U	148581	broad.mit.edu	37	1	64680524	64680524	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:64680524G>C	ENST00000371076.3	+	5	610	c.366G>C	c.(364-366)gaG>gaC	p.E122D		NM_152489.1	NP_689702.1	Q5VVX9	UBE2U_HUMAN	ubiquitin-conjugating enzyme E2U (putative)	122							ATP binding|protein binding|ubiquitin-protein ligase activity			large_intestine(3)|lung(2)|skin(1)	6						CAGTGCTAGAGAATCCAGTGA	0.333000													26	75					0	0	1	0	0
C1orf162	128346	broad.mit.edu	37	1	112019436	112019436	+	Silent	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:112019436C>G	ENST00000343534.5	+	3	304	c.54C>G	c.(52-54)ctC>ctG	p.L18L	C1orf162_ENST00000464591.1_3'UTR|C1orf162_ENST00000369718.3_Silent_p.L18L	NM_174896.2	NP_777556.1	Q8NEQ5	CA162_HUMAN	chromosome 1 open reading frame 162	18						integral to membrane				NS(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)	5		all_cancers(81;0.00116)|all_epithelial(167;0.000761)|all_lung(203;0.00277)|Lung NSC(277;0.0043)		Lung(183;0.0236)|Colorectal(144;0.0286)|all cancers(265;0.0572)|Epithelial(280;0.0862)|COAD - Colon adenocarcinoma(174;0.112)|LUSC - Lung squamous cell carcinoma(189;0.134)		AAGGCACTCTCTCCACAGCAG	0.458000													34	100					0	0	1	0	0
ARID1A	8289	broad.mit.edu	37	1	27106512	27106512	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:27106512G>A	ENST00000324856.7	+	20	6494	c.6123G>A	c.(6121-6123)gtG>gtA	p.V2041V	ARID1A_ENST00000374152.2_Silent_p.V1658V|ARID1A_ENST00000540690.1_Silent_p.V369V|ARID1A_ENST00000457599.2_Silent_p.V1824V	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	2041					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		ACCAAGGGGTGAGCTGCAACA	0.552000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								14	62					0	0	1	0	0
OSTM1	28962	broad.mit.edu	37	6	108372309	108372309	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:108372309C>A	ENST00000193322.3	-	4	794	c.709G>T	c.(709-711)Gaa>Taa	p.E237*		NM_014028.3	NP_054747.2	Q86WC4	OSTM1_HUMAN	osteopetrosis associated transmembrane protein 1	237						integral to membrane				central_nervous_system(2)|endometrium(1)|lung(2)|ovary(1)|upper_aerodigestive_tract(2)	8		all_cancers(87;3.82e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000195)|Colorectal(196;0.0293)|all_lung(197;0.0938)		BRCA - Breast invasive adenocarcinoma(108;0.0131)|Epithelial(106;0.0438)|OV - Ovarian serous cystadenocarcinoma(136;0.0571)|all cancers(137;0.0581)		TTTTGCATTTCACTGTACAGA	0.353000													15	50					6.31663e-08	6.67718e-08	1	1	0
DNAH5	1767	broad.mit.edu	37	5	13866331	13866331	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr5:13866331G>A	ENST00000265104.4	-	26	4218	c.4114C>T	c.(4114-4116)Cag>Tag	p.Q1372*	CTB-51A17.1_ENST00000503244.1_RNA	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1372	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					AAGATTACCTGAAACATGATA	0.358000									Kartagener syndrome				3	27					0	0	1	0	0
ALDH3A2	224	broad.mit.edu	37	17	19559772	19559772	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr17:19559772G>T	ENST00000176643.6	+	4	1011	c.565G>T	c.(565-567)Gtt>Ttt	p.V189F	ALDH3A2_ENST00000339618.4_Missense_Mutation_p.V189F|ALDH3A2_ENST00000579855.1_Missense_Mutation_p.V189F|ALDH3A2_ENST00000581518.1_Missense_Mutation_p.V189F|ALDH3A2_ENST00000395575.2_Missense_Mutation_p.V189F			P51648	AL3A2_HUMAN	aldehyde dehydrogenase 3 family, member A2	189					cellular aldehyde metabolic process|central nervous system development|epidermis development|lipid metabolic process|peripheral nervous system development	endoplasmic reticulum membrane|integral to membrane	3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase|aldehyde dehydrogenase (NAD) activity			endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(2)|ovary(2)|prostate(1)	13	all_cancers(12;1.39e-05)|all_epithelial(12;0.00158)|Breast(13;0.245)				NADH(DB00157)	AAACACTGCGGTTGGCAAAAT	0.443000													25	81					2.48779e-11	2.67681e-11	1	1	0
USP37	57695	broad.mit.edu	37	2	219423311	219423311	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:219423311C>A	ENST00000258399.3	-	4	478	c.66G>T	c.(64-66)tgG>tgT	p.W22C	USP37_ENST00000454775.1_Missense_Mutation_p.W22C|USP37_ENST00000338465.5_Missense_Mutation_p.W22C|USP37_ENST00000418019.1_Missense_Mutation_p.W22C|USP37_ENST00000415516.1_Intron	NM_020935.2	NP_065986	Q86T82	UBP37_HUMAN	ubiquitin specific peptidase 37	22					ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(2)|breast(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(1)|lung(7)|ovary(2)|prostate(3)|skin(5)|stomach(1)	35		Renal(207;0.0915)		Epithelial(149;1.08e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.00375)|Lung(261;0.00487)		ATCCTTCTTTCCACTTTGTAA	0.343000													33	127					1.99505e-19	2.20325e-19	1	1	0
C19orf73	55150	broad.mit.edu	37	19	49622065	49622065	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:49622065G>A	ENST00000408991.2	-	1	332	c.215C>T	c.(214-216)tCc>tTc	p.S72F		NM_018111.2	NP_060581.2	Q9NVV2	CS073_HUMAN	chromosome 19 open reading frame 73	72										large_intestine(1)|lung(2)	3						GGGCGGGGCGGAGCGAACCAT	0.692000													37	30					0	0	1	0	0
ACTRT1	139741	broad.mit.edu	37	X	127185631	127185631	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:127185631C>T	ENST00000371124.3	-	1	751	c.555G>A	c.(553-555)ggG>ggA	p.G185G		NM_138289.3	NP_612146.1	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	185						cytoplasm|cytoskeleton				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|skin(3)	34						TGATGTCCCTCCCTGCCATAC	0.537000													16	67					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73071200	73071200	+	RNA	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:73071200G>A	ENST00000429829.1	-	0	1388					NR_001564.2																						ACTGCGGCAAGACCTTCAGCC	0.527000													21	180					0	0	1	0	0
ABCC12	94160	broad.mit.edu	37	16	48125064	48125064	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr16:48125064G>C	ENST00000311303.3	-	23	3597	c.3252C>G	c.(3250-3252)ttC>ttG	p.F1084L	ABCC12_ENST00000448542.1_3'UTR|ABCC12_ENST00000416054.1_3'UTR	NM_033226.2	NP_150229.2	Q96J65	MRP9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 12	1084						integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|liver(1)|lung(43)|ovary(2)|prostate(3)|skin(7)|urinary_tract(1)	90		all_cancers(37;0.0474)|all_lung(18;0.047)				CCACGGAGGTGAATTTGGCTT	0.517000													59	65					0	0	1	0	0
PTPRS	5802	broad.mit.edu	37	19	5211777	5211777	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:5211777C>T	ENST00000372412.4	-	33	5294	c.5061G>A	c.(5059-5061)cgG>cgA	p.R1687R	PTPRS_ENST00000348075.2_Silent_p.R1648R|PTPRS_ENST00000353284.2_Silent_p.R1239R|PTPRS_ENST00000357368.4_Silent_p.R1686R|PTPRS_ENST00000588552.1_5'UTR|PTPRS_ENST00000262963.6_Silent_p.R1666R|PTPRS_ENST00000587303.1_Silent_p.R1686R|PTPRS_ENST00000588012.1_Silent_p.R1648R|PTPRS_ENST00000592099.1_Silent_p.R1239R			Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type, S	1686	Tyrosine-protein phosphatase 2.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(9)|ovary(4)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)	61				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		AGTTAGCCAGCCGCTGTGGGG	0.562000													7	35					0	0	1	0	0
TRAPPC4	51399	broad.mit.edu	37	11	118890872	118890872	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:118890872C>G	ENST00000533632.1	+	3	727	c.363C>G	c.(361-363)atC>atG	p.I121M	TRAPPC4_ENST00000528230.1_Missense_Mutation_p.I78M|TRAPPC4_ENST00000359005.4_Missense_Mutation_p.I121M|TRAPPC4_ENST00000434101.2_Intron|TRAPPC4_ENST00000525303.1_Intron|TRAPPC4_ENST00000533058.1_Missense_Mutation_p.I121M	NM_016146.4	NP_057230.1	Q9Y296	TPPC4_HUMAN	trafficking protein particle complex 4	121					dendrite development|ER to Golgi vesicle-mediated transport	cis-Golgi network|dendrite|endoplasmic reticulum|Golgi stack|synaptic vesicle	protein binding			NS(1)|endometrium(1)|large_intestine(2)|lung(1)	5	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_neural(223;0.224)|all_hematologic(192;0.243)		BRCA - Breast invasive adenocarcinoma(274;7.58e-05)		TCTTTGCCATCGGCTCCCAGC	0.488000													10	47					0	0	1	0	0
SDPR	8436	broad.mit.edu	37	2	192711334	192711334	+	Silent	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:192711334G>C	ENST00000304141.4	-	1	647	c.318C>G	c.(316-318)tcC>tcG	p.S106S	AC098617.1_ENST00000424116.2_RNA	NM_004657.5	NP_004648.1	O95810	SDPR_HUMAN	serum deprivation response	106						caveola|cytosol	phosphatidylserine binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|urinary_tract(3)	23			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	TGTTGCTGGTGGAGGCCTGGT	0.597000													11	43					0	0	1	0	0
OR9G4	283189	broad.mit.edu	37	11	56510367	56510367	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:56510367C>T	ENST00000302957.3	-	1	920	c.921G>A	c.(919-921)ctG>ctA	p.L307L		NM_001005284.1	NP_001005284.1	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G, member 4	307					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						CTTTGTTTCTCAGGCTATAGA	0.428000													18	107					0	0	1	0	0
ADAM22	53616	broad.mit.edu	37	7	87762245	87762245	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:87762245G>A	ENST00000398204.4	+	12	1379	c.1056G>A	c.(1054-1056)ctG>ctA	p.L352L	ADAM22_ENST00000265727.7_Silent_p.L352L|ADAM22_ENST00000398201.4_Silent_p.L352L|ADAM22_ENST00000398209.3_Silent_p.L352L|ADAM22_ENST00000315984.7_Silent_p.L352L	NM_016351.4|NM_021723.3	NP_057435.2|NP_068369.1	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22	352	Peptidase M12B.				cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			endometrium(7)|kidney(4)|large_intestine(7)|liver(2)|lung(20)|ovary(6)|prostate(4)|skin(3)	53	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			GCTCGTTGCTGAAAGGAGGAG	0.408000													19	74					0	0	1	0	0
E2F1	1869	broad.mit.edu	37	20	32268189	32268189	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr20:32268189G>A	ENST00000343380.5	-	2	434	c.295C>T	c.(295-297)Cag>Tag	p.Q99*		NM_005225.2	NP_005216.1	Q01094	E2F1_HUMAN	E2F transcription factor 1	99	Cyclin A/CDK2 binding.			KRRLDLETDHQYLAESSGPARGR -> RTPGTPRRQRRLCP PRRPGRAPC (in Ref. 8; AAD14150).	apoptosis|cell proliferation|G1 phase of mitotic cell cycle|G2 phase of mitotic cell cycle|mRNA stabilization|negative regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of fibroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle	mitochondrion|Rb-E2F complex	sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription factor binding			NS(2)|breast(1)|endometrium(3)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	16						GCCAGGTACTGATGGTCAGTT	0.622000													14	30					0	0	1	0	0
BUD31	8896	broad.mit.edu	37	7	99013881	99013881	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:99013881G>A	ENST00000403633.2	+	4	744	c.215G>A	c.(214-216)aGa>aAa	p.R72K	BUD31_ENST00000431419.1_Missense_Mutation_p.R43K|BUD31_ENST00000222969.5_Missense_Mutation_p.R72K|BUD31_ENST00000456893.1_Intron			P41223	BUD31_HUMAN	BUD31 homolog (S. cerevisiae)	72					regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity			autonomic_ganglia(1)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|ovary(1)	4	all_cancers(62;1.76e-08)|all_epithelial(64;1.63e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			GCCATCAGCAGAGGTAATTAG	0.473000													14	56					0	0	1	0	0
SYNJ1	8867	broad.mit.edu	37	21	34011403	34011403	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr21:34011403G>C	ENST00000382499.2	-	31	3846	c.3847C>G	c.(3847-3849)Cag>Gag	p.Q1283E	SYNJ1_ENST00000357345.3_Missense_Mutation_p.Q1228E|SYNJ1_ENST00000382491.3_Missense_Mutation_p.Q1197E|SYNJ1_ENST00000433931.2_Missense_Mutation_p.Q1283E|SYNJ1_ENST00000322229.7_Missense_Mutation_p.Q1244E	NM_203446.2	NP_982271.2	O43426	SYNJ1_HUMAN	synaptojanin 1	1244	Pro-rich.						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|lung(11)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	57						AAAGCAGCCTGAGGCTTCAGT	0.488000													16	53					0	0	1	0	0
ZNF146	7705	broad.mit.edu	37	19	36727581	36727581	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:36727581C>T	ENST00000456324.1	+	3	1688	c.239C>T	c.(238-240)tCa>tTa	p.S80L	ZNF565_ENST00000355114.5_Intron|ZNF146_ENST00000443387.2_Missense_Mutation_p.S80L	NM_001099638.1|NM_001099639.1	NP_001093108.1|NP_001093109.1	Q15072	OZF_HUMAN	zinc finger protein 146	80					regulation of transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|heparin binding|zinc ion binding			kidney(1)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	11	Esophageal squamous(110;0.162)					TGTGGAAAATCATTTAGCCAG	0.398000													15	74					0	0	1	0	0
PNCK	139728	broad.mit.edu	37	X	152935946	152935946	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:152935946G>C	ENST00000393831.2	-	11	1501	c.1067C>G	c.(1066-1068)tCa>tGa	p.S356*	PNCK_ENST00000370150.1_Nonsense_Mutation_p.S333*|PNCK_ENST00000370142.1_Nonsense_Mutation_p.S356*|PNCK_ENST00000340888.3_Nonsense_Mutation_p.S333*|PNCK_ENST00000447676.2_Nonsense_Mutation_p.S416*|PNCK_ENST00000370145.4_Nonsense_Mutation_p.S350*	NM_001039582.3	NP_001034671.3	Q6P2M8	KCC1B_HUMAN	pregnancy up-regulated nonubiquitous CaM kinase	333						cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(2)|lung(3)|skin(1)	6	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					ACGGAGGCCTGAGTGGCTGTG	0.672000													3	9					0	0	1	0	0
DUSP8	1850	broad.mit.edu	37	11	1579102	1579102	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:1579102G>C	ENST00000397374.3	-	6	870	c.743C>G	c.(742-744)gCt>gGt	p.A248G	DUSP8_ENST00000528778.1_5'UTR|DUSP8_ENST00000331588.4_Missense_Mutation_p.A248G	NM_004420.2	NP_004411.2	Q13202	DUS8_HUMAN	dual specificity phosphatase 8	248	Tyrosine-protein phosphatase.				inactivation of MAPK activity	cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			endometrium(1)|lung(2)|prostate(1)|urinary_tract(1)	5		all_epithelial(84;0.000134)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000621)|Lung(200;0.0687)|LUSC - Lung squamous cell carcinoma(625;0.0825)		GGAGATGCCAGCCAGACAGTG	0.617000													12	28					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15617559	15617559	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr10:15617559G>C	ENST00000378076.3	-	24	2760	c.2407C>G	c.(2407-2409)Cat>Gat	p.H803D		NM_003638.1	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8	803					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						TCCCAGTTATGAATGGGCAGA	0.443000													55	58					0	0	1	0	0
REXO2	25996	broad.mit.edu	37	11	114310358	114310358	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:114310358G>A	ENST00000265881.5	+	1	251	c.108G>A	c.(106-108)ggG>ggA	p.G36G	REXO2_ENST00000539754.1_Silent_p.G36G|RP11-212D19.4_ENST00000544347.1_Intron|REXO2_ENST00000544196.1_Silent_p.G36G|REXO2_ENST00000539275.1_Silent_p.G36G	NM_015523.3	NP_056338.2	Q9Y3B8	ORN_HUMAN	RNA exonuclease 2	36					nucleotide metabolic process	mitochondrion|nucleus	3'-5' exonuclease activity|nucleic acid binding			cervix(1)|endometrium(1)|kidney(1)|lung(1)	4		all_cancers(61;5.06e-12)|all_epithelial(67;5.3e-06)|all_hematologic(158;7.68e-05)|Acute lymphoblastic leukemia(157;0.000966)|Melanoma(852;0.00153)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Breast(348;0.0818)|Prostate(24;0.104)		BRCA - Breast invasive adenocarcinoma(274;2.65e-06)|Epithelial(105;6.09e-05)|all cancers(92;0.000494)		TGGCGGCAGGGGAGAGCATGG	0.697000											OREG0021351	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	17					0	0	1	0	0
PDE1C	5137	broad.mit.edu	37	7	32110084	32110084	+	Translation_Start_Site	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:32110084G>C	ENST00000396191.1	-	0	377				PDE1C_ENST00000396184.3_Intron|PDE1C_ENST00000321453.7_Intron|PDE1C_ENST00000396182.2_De_novo_Start_InFrame|PDE1C_ENST00000396193.1_Intron	NM_001191057.1	NP_001177986.1	Q14123	PDE1C_HUMAN	phosphodiesterase 1C, calmodulin-dependent 70kDa						activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(38)|prostate(4)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	81			GBM - Glioblastoma multiforme(11;0.216)			CCCAGCTCGCGATGCCCAGCC	0.672000													6	9					0	0	1	0	0
FHOD1	29109	broad.mit.edu	37	16	67267925	67267925	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr16:67267925C>G	ENST00000258201.4	-	13	1928	c.1681G>C	c.(1681-1683)Gag>Cag	p.E561Q		NM_013241.2	NP_037373.2	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	561	FH1.				actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(4)|endometrium(3)|kidney(3)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	34		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		TCCACAGACTCTACATTCAGC	0.617000													9	35					0	0	1	0	0
POM121	9883	broad.mit.edu	37	7	72412747	72412747	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:72412747G>C	ENST00000395270.1	+	14	2461	c.1420G>C	c.(1420-1422)Gag>Cag	p.E474Q	POM121_ENST00000434423.2_Missense_Mutation_p.E739Q|POM121_ENST00000446813.1_Missense_Mutation_p.E474Q|POM121_ENST00000358357.3_Missense_Mutation_p.E474Q|POM121_ENST00000257622.4_Missense_Mutation_p.E474Q	NM_001257190.1	NP_001244119.1	Q96HA1	P121A_HUMAN	POM121 transmembrane nucleoporin	739	Pore side (Potential).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|breast(1)|endometrium(9)|kidney(4)|large_intestine(6)|lung(12)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Lung NSC(55;0.163)				ACCCAAGAGTGAGAAGGAAGG	0.627000													6	24					0	0	1	0	0
SESN3	143686	broad.mit.edu	37	11	94908802	94908802	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:94908802C>G	ENST00000536441.1	-	9	1588	c.1252G>C	c.(1252-1254)Gat>Cat	p.D418H	RP11-712B9.2_ENST00000534864.1_RNA|RP11-712B9.2_ENST00000534891.1_RNA|SESN3_ENST00000278499.2_Missense_Mutation_p.D279H	NM_001271594.1|NM_144665.2	NP_001258523.1|NP_653266.2	P58005	SESN3_HUMAN	sestrin 3	418					cell cycle arrest	nucleus				endometrium(5)|large_intestine(6)|lung(3)|skin(1)|stomach(1)	16		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)		BRCA - Breast invasive adenocarcinoma(274;0.234)		TCATAGTCATCATACCTACGA	0.308000													5	17					0	0	1	0	0
SLX4IP	128710	broad.mit.edu	37	20	10601965	10601965	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr20:10601965G>C	ENST00000334534.5	+	7	589	c.409G>C	c.(409-411)Gaa>Caa	p.E137Q		NM_001009608.1	NP_001009608.1			SLX4 interacting protein																		GGAGTAGACAGAAAGAGTTCT	0.403000													5	32					0	0	1	0	0
TNS4	84951	broad.mit.edu	37	17	38637021	38637021	+	Splice_Site	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr17:38637021C>T	ENST00000254051.6	-	9	1831		c.e9-1			NM_032865.5	NP_116254.4	Q8IZW8	TENS4_HUMAN	tensin 4						apoptosis|protein localization	cytoplasm|cytoskeleton|focal adhesion	actin binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	30		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(5;5.91e-05)			CCTCCCAGTTCTGAGCCAAGG	0.597000													7	23					0	0	1	0	0
SAMD9	54809	broad.mit.edu	37	7	92731256	92731256	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:92731256C>A	ENST00000379958.2	-	3	4424	c.4155G>T	c.(4153-4155)aaG>aaT	p.K1385N		NM_001193307.1|NM_017654.3	NP_001180236.1|NP_060124.2	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	1385						cytoplasm				NS(1)|breast(4)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(20)|lung(32)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	88	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			TGAAATTTAGCTTTTCTTTTG	0.353000													42	45					1.47197e-15	1.61631e-15	1	1	0
PCDH9	5101	broad.mit.edu	37	13	66878845	66878845	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr13:66878845A>G	ENST00000544246.1	-	5	4347	c.3656T>C	c.(3655-3657)cTg>cCg	p.L1219P	PCDH9-AS1_ENST00000430861.1_RNA|PCDH9_ENST00000328454.5_Missense_Mutation_p.L1185P|PCDH9_ENST00000377865.2_Missense_Mutation_p.L1219P|PCDH9_ENST00000456367.1_Missense_Mutation_p.L1185P	NM_203487.2	NP_982354.1	Q9HC56	PCDH9_HUMAN	protocadherin 9	1219					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(33)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	103		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		ATAAGACTTCAGATTTGCCAG	0.443000													4	35					0	0	1	0	0
GTF3C1	2975	broad.mit.edu	37	16	27492442	27492442	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr16:27492442G>A	ENST00000356183.4	-	27	4169	c.4154C>T	c.(4153-4155)tCt>tTt	p.S1385F	GTF3C1_ENST00000561623.1_Missense_Mutation_p.S1385F	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	1385						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						TTCAAGGTTAGAATTCCTTAG	0.473000													51	46					0	0	1	0	0
ACTN1	87	broad.mit.edu	37	14	69346680	69346680	+	Splice_Site	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr14:69346680C>T	ENST00000193403.6	-	18	2662	c.2279G>A	c.(2278-2280)cGg>cAg	p.R760Q	ACTN1_ENST00000394419.4_Splice_Site_p.R760Q|ACTN1_ENST00000538545.2_Splice_Site_p.R760Q|ACTN1_ENST00000376839.3_Splice_Site_p.R695Q|ACTN1_ENST00000438964.2_Splice_Site_p.R760Q	NM_001102.3	NP_001093.1	P12814	ACTN1_HUMAN	actinin, alpha 1	760	EF-hand 1.				focal adhesion assembly|negative regulation of cellular component movement|platelet activation|platelet degranulation|regulation of apoptosis	actin cytoskeleton|cytosol|extracellular region|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|sarcomere	actin binding|calcium ion binding|integrin binding|vinculin binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(9)|prostate(2)|urinary_tract(1)	27				BRCA - Breast invasive adenocarcinoma(234;0.00605)|all cancers(60;0.00846)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		GGCTCTCACCCGGTCAAAGTG	0.612000													6	16					0	0	1	0	0
HIVEP1	3096	broad.mit.edu	37	6	12130067	12130067	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:12130067G>C	ENST00000379388.2	+	5	6483	c.6151G>C	c.(6151-6153)Gat>Cat	p.D2051H	HIVEP1_ENST00000541134.1_Intron	NM_002114.2	NP_002105.2	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer binding protein 1	2051					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(11)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	90	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				CAGTGAGCAAGATAAAGAAAA	0.308000													9	47					0	0	1	0	0
PTPRU	10076	broad.mit.edu	37	1	29647256	29647256	+	Silent	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:29647256C>G	ENST00000323874.8	+	27	3875	c.3765C>G	c.(3763-3765)ccC>ccG	p.P1255P	PTPRU_ENST00000356870.3_Silent_p.P1255P|PTPRU_ENST00000460170.2_Silent_p.P1255P|PTPRU_ENST00000373779.3_Silent_p.P1249P|PTPRU_ENST00000345512.3_Silent_p.P1259P|PTPRU_ENST00000428026.2_Silent_p.P1246P			Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	1259	Tyrosine-protein phosphatase 2.				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(26)|ovary(1)|prostate(3)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	79		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		GCACCACGCCCGACTTCTGGC	0.642000													12	33					0	0	1	0	0
NELL2	4753	broad.mit.edu	37	12	44926496	44926496	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:44926496C>A	ENST00000429094.2	-	16	2176	c.1672G>T	c.(1672-1674)Gaa>Taa	p.E558*	NELL2_ENST00000437801.2_Nonsense_Mutation_p.E608*|NELL2_ENST00000549027.1_Nonsense_Mutation_p.E557*|NELL2_ENST00000395487.2_Nonsense_Mutation_p.E557*|NELL2_ENST00000333837.4_Nonsense_Mutation_p.E581*|NELL2_ENST00000452445.2_Nonsense_Mutation_p.E558*|NELL2_ENST00000551601.1_Intron	NM_001145108.1	NP_001138580.1	Q99435	NELL2_HUMAN	NEL-like 2 (chicken)	558	EGF-like 5; calcium-binding (Potential).				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(16)|lung(30)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	65	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		TCAGAGCATTCATCAATGTCT	0.368000													14	59					6.81908e-15	7.47073e-15	1	1	0
MST1	4485	broad.mit.edu	37	3	49723877	49723877	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:49723877G>A	ENST00000449682.2	-	8	1246	c.885C>T	c.(883-885)gtC>gtT	p.V295V	MST1_ENST00000545762.1_3'UTR|MST1_ENST00000383728.3_Silent_p.V220V	NM_020998.3	NP_066278.3	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth factor-like)	281	Kringle 3.				proteolysis	extracellular region	serine-type endopeptidase activity			NS(4)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(1)|large_intestine(1)|lung(9)|prostate(2)|skin(9)|stomach(1)|urinary_tract(2)	41				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		GGAAGCAGCTGACAGTTGTGG	0.662000													11	26					0	0	1	0	0
KRT33B	3884	broad.mit.edu	37	17	39525672	39525672	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr17:39525672C>G	ENST00000251646.3	-	1	380	c.331G>C	c.(331-333)Gag>Cag	p.E111Q		NM_002279.4	NP_002270.1	Q14525	KT33B_HUMAN	keratin 33B	111	Coil 1B.|Rod.					intermediate filament	protein binding|structural molecule activity			NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|lung(6)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)	21		Breast(137;0.000496)				TGGAGCTCCTCAATGGTCTTG	0.532000													17	29					0	0	1	0	0
IQCJ-SCHIP1	100505385	broad.mit.edu	37	3	159614545	159614545	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:159614545G>A	ENST00000337808.6	+	8	2023	c.1446G>A	c.(1444-1446)gaG>gaA	p.E482E	IQCJ-SCHIP1_ENST00000527095.1_Silent_p.E250E|SCHIP1_ENST00000482804.1_Silent_p.E255E|IQCJ-SCHIP1_ENST00000412423.2_Silent_p.E469E|IQCJ-SCHIP1_ENST00000485419.1_Silent_p.E558E|IQCJ-SCHIP1_ENST00000476809.1_Silent_p.E531E|SCHIP1_ENST00000445224.2_Silent_p.E239E	NM_001197107.1|NM_014575.3	NP_001184036.1|NP_055390.1	Q9P0W5	SCHI1_HUMAN		482						cytoplasm	identical protein binding|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(7)	12						ACATGGCAGAGAAAATGCCTG	0.373000													6	27					0	0	1	0	0
PPFIBP2	8495	broad.mit.edu	37	11	7655762	7655762	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:7655762G>C	ENST00000299492.4	+	13	1561	c.1173G>C	c.(1171-1173)ttG>ttC	p.L391F	PPFIBP2_ENST00000533792.1_Missense_Mutation_p.L233F|PPFIBP2_ENST00000528883.1_Missense_Mutation_p.L279F|PPFIBP2_ENST00000530582.1_3'UTR|PPFIBP2_ENST00000530181.1_Missense_Mutation_p.L248F	NM_003621.3	NP_003612	Q8ND30	LIPB2_HUMAN	PTPRF interacting protein, binding protein 2 (liprin beta 2)	391					cell communication|DNA integration	intracellular	DNA binding|integrase activity|protein binding			breast(8)|cervix(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32				Epithelial(150;2.01e-07)|BRCA - Breast invasive adenocarcinoma(625;0.236)		TAGAAGACTTGAGAAGTGAAT	0.398000													17	86					0	0	1	0	0
C2orf54	79919	broad.mit.edu	37	2	241831158	241831158	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:241831158C>T	ENST00000307486.8	-	2	188	c.90G>A	c.(88-90)ctG>ctA	p.L30L	C2orf54_ENST00000402775.2_Silent_p.L11L|C2orf54_ENST00000388934.4_Silent_p.L179L	NM_001282921.1	NP_001269850.1	Q08AI8	CB054_HUMAN	chromosome 2 open reading frame 54	179										haematopoietic_and_lymphoid_tissue(1)|lung(4)|prostate(1)	6		all_epithelial(40;3.99e-16)|Breast(86;2.35e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|Lung NSC(271;0.094)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;8.14e-32)|all cancers(36;4.77e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;4.88e-06)|Lung(119;0.000452)|LUSC - Lung squamous cell carcinoma(224;0.00415)|Colorectal(34;0.021)|COAD - Colon adenocarcinoma(134;0.15)		GCTCCTCCCTCAGGCTGGCCG	0.652000													16	28					0	0	1	0	0
ANO5	203859	broad.mit.edu	37	11	22249057	22249057	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:22249057C>A	ENST00000324559.8	+	7	890	c.573C>A	c.(571-573)ttC>ttA	p.F191L		NM_001142649.1|NM_213599.2	NP_001136121.1|NP_998764.1	Q75V66	ANO5_HUMAN	anoctamin 5	191						chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			breast(2)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(12)|lung(36)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						CTGCACAATTCAGCAGACATC	0.473000													9	47					0.000442599	0.000457321	1	1	0
EML2	24139	broad.mit.edu	37	19	46120942	46120942	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:46120942G>A	ENST00000536630.1	-	16	1847	c.1709C>T	c.(1708-1710)tCa>tTa	p.S570L	EML2_ENST00000245925.3_Missense_Mutation_p.S423L|EML2_ENST00000587152.1_Missense_Mutation_p.S624L|EML2_ENST00000589876.1_Missense_Mutation_p.S423L	NM_001193269.1	NP_001180198.1	O95834	EMAL2_HUMAN	echinoderm microtubule associated protein like 2	423					sensory perception of sound|visual perception	cytoplasm|intracellular membrane-bounded organelle|microtubule|microtubule associated complex	catalytic activity|protein binding			NS(1)|breast(2)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(13)|ovary(1)|urinary_tract(1)	31		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00553)|GBM - Glioblastoma multiforme(486;0.131)|Epithelial(262;0.197)		GAAGCCGGCTGAGCGGGCAGG	0.607000													8	11					0	0	1	0	0
PPP1R15B	84919	broad.mit.edu	37	1	204380369	204380369	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:204380369C>G	ENST00000367188.4	-	1	550	c.171G>C	c.(169-171)gaG>gaC	p.E57D	RP11-739N20.2_ENST00000443515.1_RNA	NM_032833.3	NP_116222.3	Q5SWA1	PR15B_HUMAN	protein phosphatase 1, regulatory subunit 15B	57					regulation of translation					breast(3)|cervix(1)|kidney(4)|large_intestine(3)|lung(16)|ovary(1)|pancreas(2)|skin(1)|urinary_tract(3)	34	all_cancers(21;0.0032)|all_neural(3;0.0218)|Glioma(3;0.0382)|Breast(84;0.179)|all_epithelial(62;0.193)|Prostate(682;0.227)		all cancers(3;1.14e-29)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.139)			TGACCCGAGTCTCGGGCTGGG	0.582000													22	92					0	0	1	0	0
CLEC12B	387837	broad.mit.edu	37	12	10167319	10167319	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:10167319G>A	ENST00000396502.1	+	3	516	c.388G>A	c.(388-390)Gag>Aag	p.E130K	CLEC12B_ENST00000338896.5_Missense_Mutation_p.E130K	NM_205852.2	NP_995324.2	Q2HXU8	CL12B_HUMAN	C-type lectin domain family 12, member B	130						integral to membrane|plasma membrane	receptor activity|sugar binding			central_nervous_system(2)|large_intestine(2)|lung(5)	9						ACTGTGCCAAGAGCTAATCAT	0.448000													11	20					0	0	1	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													5	54					0	0	1	0	0
NACA	4666	broad.mit.edu	37	12	57113652	57113652	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:57113652C>T	ENST00000454682.1	-	3	1943	c.1662G>A	c.(1660-1662)aaG>aaA	p.K554K	NACA_ENST00000550952.1_Silent_p.K554K|NACA_ENST00000393891.4_Intron|NACA_ENST00000546392.1_Intron|NACA_ENST00000548563.1_Intron|NACA_ENST00000552540.1_Intron|NACA_ENST00000356769.3_Intron|NACA_ENST00000551793.1_Intron	NM_001113203.2	NP_001106674.2	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha subunit	28					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	10						TAGGGTCTTTCTTGGTGGTGA	0.468000			T	BCL6	NHL								9	15					0	0	1	0	0
GPBP1L1	60313	broad.mit.edu	37	1	46093957	46093957	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:46093957C>T	ENST00000355105.3	-	13	2756	c.1396G>A	c.(1396-1398)Gaa>Aaa	p.E466K	GPBP1L1_ENST00000479235.1_5'UTR|GPBP1L1_ENST00000290795.3_Missense_Mutation_p.E466K	NM_021639.4	NP_067652.1	Q9HC44	GPBL1_HUMAN	GC-rich promoter binding protein 1-like 1	466					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding		GPBP1L1/MAST2_ENST00000361297(2)	breast(1)|endometrium(2)|large_intestine(4)|lung(10)|ovary(1)|skin(2)|stomach(1)	21	Acute lymphoblastic leukemia(166;0.155)					TCTGATGTTTCACTGCTACTG	0.458000													97	187					0	0	1	0	0
C10orf137	26098	broad.mit.edu	37	10	127429670	127429670	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr10:127429670G>C	ENST00000337623.3	+	16	2274	c.2169G>C	c.(2167-2169)caG>caC	p.Q723H	C10orf137_ENST00000356792.4_Missense_Mutation_p.Q757H	NM_015608.2	NP_056423.2	Q3B7T1	EDRF1_HUMAN	chromosome 10 open reading frame 137	757					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(12)|lung(20)|ovary(8)|pancreas(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	61		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				TGCTGGCCCAGAATGCAAATA	0.428000													20	46					0	0	1	0	0
GPR75-ASB3	100302652	broad.mit.edu	37	2	53978035	53978035	+	Missense_Mutation	SNP	G	G	C	rs35388971		TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:53978035G>C	ENST00000263634.3	-	3	374	c.240C>G	c.(238-240)ttC>ttG	p.F80L	GPR75-ASB3_ENST00000482829.1_5'UTR|ASB3_ENST00000406625.2_Missense_Mutation_p.F115L|ASB3_ENST00000498475.2_Intron|GPR75-ASB3_ENST00000352846.3_Missense_Mutation_p.F118L|GPR75-ASB3_ENST00000394717.2_Missense_Mutation_p.F7L|GPR75-ASB3_ENST00000406687.1_Missense_Mutation_p.F7L	NM_016115.4	NP_057199.1	Q2TAI4	Q2TAI4_HUMAN		115					intracellular signal transduction												GCAAAGCACAGAAACCTTCAA	0.383000													65	53					0	0	1	0	0
VNN2	8875	broad.mit.edu	37	6	133072427	133072427	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:133072427C>T	ENST00000326499.6	-	5	1181	c.1057G>A	c.(1057-1059)Gaa>Aaa	p.E353K	VNN2_ENST00000525289.1_Intron|VNN2_ENST00000525270.1_Missense_Mutation_p.E300K	NM_004665.2	NP_004656	O95498	VNN2_HUMAN	vanin 2	353					cellular component movement|pantothenate metabolic process	anchored to membrane|plasma membrane	pantetheine hydrolase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(155;0.00237)|GBM - Glioblastoma multiforme(226;0.0267)		CCTGCATTTTCAAAAAGTTCT	0.398000													20	64					0	0	1	0	0
ABCA6	23460	broad.mit.edu	37	17	67092798	67092798	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr17:67092798G>C	ENST00000284425.2	-	24	3439	c.3265C>G	c.(3265-3267)Ctt>Gtt	p.L1089V	ABCA6_ENST00000446604.2_5'UTR	NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	1089					transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					CTTGTAATAAGAAGGTACTGC	0.299000													10	43					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124336080	124336080	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr10:124336080C>G	ENST00000338354.3	+	7	555	c.449C>G	c.(448-450)tCa>tGa	p.S150*	DMBT1_ENST00000368909.3_Nonsense_Mutation_p.S150*|DMBT1_ENST00000359586.6_Nonsense_Mutation_p.S150*|DMBT1_ENST00000368955.3_Nonsense_Mutation_p.S150*|DMBT1_ENST00000344338.3_Nonsense_Mutation_p.S150*|DMBT1_ENST00000330163.4_Nonsense_Mutation_p.S150*|DMBT1_ENST00000368956.2_Nonsense_Mutation_p.S150*			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	150	SRCR 1.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TGGGCCATGTCAGCTCCAGGA	0.602000													36	137					0	0	1	0	0
PRAMEF4	400735	broad.mit.edu	37	1	12939599	12939599	+	Silent	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:12939599C>G	ENST00000235349.5	-	4	1273	c.1203G>C	c.(1201-1203)ctG>ctC	p.L401L		NM_001009611.2	NP_001009611.1	O60810	PRAM4_HUMAN	PRAME family member 4	401										breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|prostate(3)|skin(1)	24	Ovarian(185;0.249)	Lung NSC(185;3.67e-05)|all_lung(284;4.03e-05)|Renal(390;0.000147)|Breast(348;0.000278)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TTGTGTGGCTCAGCAGGTTCT	0.537000													116	255					0	0	1	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21068999	21068999	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:21068999T>A	ENST00000381545.3	+	16	2146	c.1927T>A	c.(1927-1929)Ttc>Atc	p.F643I	LST3_ENST00000381541.3_Intron|SLCO1B3_ENST00000553473.1_Intron|LST3_ENST00000540229.1_Intron|SLCO1B3_ENST00000261196.2_Missense_Mutation_p.F643I|SLCO1B7_ENST00000554957.1_Intron	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	643					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					ATATATTGTTTTCATTTTTGC	0.299000													5	82					0	0	1	0	0
NFE2L3	9603	broad.mit.edu	37	7	26217662	26217662	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:26217662C>T	ENST00000056233.3	+	2	929	c.670C>T	c.(670-672)Cag>Tag	p.Q224*		NM_004289.6	NP_004280.5	Q9Y4A8	NF2L3_HUMAN	nuclear factor, erythroid 2-like 3	224					transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|skin(5)|urinary_tract(7)	29						GAACTCACTTCAGCAGAATGA	0.438000													13	26					0	0	1	0	0
SYNJ1	8867	broad.mit.edu	37	21	34003394	34003394	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr21:34003394G>C	ENST00000382491.3	-	28	4616	c.4492C>G	c.(4492-4494)Ctg>Gtg	p.L1498V	SYNJ1_ENST00000357345.3_3'UTR|SYNJ1_ENST00000433931.2_Missense_Mutation_p.L1584V|SYNJ1_ENST00000322229.7_Missense_Mutation_p.L1545V|SYNJ1_ENST00000382499.2_3'UTR	NM_001160306.1	NP_001153778.1	O43426	SYNJ1_HUMAN	synaptojanin 1	1545	Pro-rich.						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|lung(11)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	57						GGCGGGAGCAGAGGGACAGGA	0.517000													15	44					0	0	1	0	0
ZCCHC24	219654	broad.mit.edu	37	10	81192416	81192416	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr10:81192416C>T	ENST00000372333.3	-	2	216	c.166G>A	c.(166-168)Gac>Aac	p.D56N	ZCCHC24_ENST00000372336.3_Silent_p.L115L			Q8N2G6	ZCH24_HUMAN	zinc finger, CCHC domain containing 24	31							nucleic acid binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(3)|lung(1)|skin(1)	9						AGGTGAGGGTCAGGTCTGAGA	0.612000													13	21					0	0	1	0	0
CRISPLD1	83690	broad.mit.edu	37	8	75926323	75926323	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr8:75926323C>T	ENST00000262207.4	+	5	1080	c.612C>T	c.(610-612)tgC>tgT	p.C204C	CRISPLD1_ENST00000517786.1_Intron|CRISPLD1_ENST00000523524.1_Silent_p.C16C	NM_031461.5	NP_113649.1	Q9H336	CRLD1_HUMAN	cysteine-rich secretory protein LCCL domain containing 1	204						extracellular region				biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(7)|large_intestine(10)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Breast(64;0.0799)		Epithelial(68;0.155)|BRCA - Breast invasive adenocarcinoma(89;0.161)			ACCTGGTGTGCAATTACTCCC	0.408000													13	42					0	0	1	0	0
MANSC1	54682	broad.mit.edu	37	12	12483053	12483053	+	Missense_Mutation	SNP	C	C	T	rs138511907		TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:12483053C>T	ENST00000535902.1	-	4	1767	c.1204G>A	c.(1204-1206)Gtc>Atc	p.V402I	MANSC1_ENST00000396349.3_Missense_Mutation_p.V368I|MANSC1_ENST00000545735.1_Missense_Mutation_p.V321I			Q9H8J5	MANS1_HUMAN	MANSC domain containing 1	402						integral to membrane				breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|skin(1)|stomach(4)	23		Prostate(47;0.0865)		BRCA - Breast invasive adenocarcinoma(232;0.185)		CCCAGGAGGACGAGGCCTATC	0.483000													9	28					0	0	1	0	0
MAP4K2	5871	broad.mit.edu	37	11	64557919	64557919	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:64557919G>A	ENST00000294066.2	-	28	2199	c.2108C>T	c.(2107-2109)tCg>tTg	p.S703L	MAP4K2_ENST00000377350.3_Missense_Mutation_p.S695L	NM_004579.3	NP_004570.2	Q12851	M4K2_HUMAN	mitogen-activated protein kinase kinase kinase kinase 2	703	CNH.				activation of JUN kinase activity|immune response|positive regulation of JNK cascade|vesicle targeting	basolateral plasma membrane|Golgi membrane|soluble fraction	ATP binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity|small GTPase regulator activity			cervix(1)|lung(3)|ovary(1)|pancreas(1)|urinary_tract(2)	8						CTGCTGGGCCGAGCCTGGGAT	0.622000													6	27					0	0	1	0	0
DNHD1	144132	broad.mit.edu	37	11	6592004	6592004	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:6592004C>T	ENST00000254579.6	+	42	13826	c.13262C>T	c.(13261-13263)tCa>tTa	p.S4421L	DNHD1_ENST00000527990.2_Missense_Mutation_p.S4421L	NM_144666.2	NP_653267.2	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1	4421					microtubule-based movement	dynein complex	microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(4)|endometrium(13)|kidney(6)|large_intestine(11)|lung(14)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	55		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		CAGCGGAGTTCACCCGTGTGG	0.647000													5	11					0	0	1	0	0
IRF5	3663	broad.mit.edu	37	7	128588054	128588054	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:128588054C>T	ENST00000402030.2	+	7	1083	c.1011C>T	c.(1009-1011)atC>atT	p.I337I	IRF5_ENST00000249375.4_Silent_p.I337I|IRF5_ENST00000473745.1_Silent_p.I337I|IRF5_ENST00000477535.1_Silent_p.I251I|IRF5_ENST00000357234.5_Silent_p.I353I	NM_001098629.1|NM_001098630.1	NP_001092099.1|NP_001092100.1	Q13568	IRF5_HUMAN	interferon regulatory factor 5	337					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(1)|prostate(1)	15						TTTATGCCATCCGCCTGTGTC	0.597000													7	76					0	0	1	0	0
MAP3K7	6885	broad.mit.edu	37	6	91226369	91226369	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:91226369C>T	ENST00000369329.3	-	17	1833	c.1672G>A	c.(1672-1674)Gaa>Aaa	p.E558K	MAP3K7_ENST00000479630.1_5'UTR|MAP3K7_ENST00000369325.3_Silent_p.*519*|MAP3K7_ENST00000369320.1_Missense_Mutation_p.E212K|MAP3K7_ENST00000369327.3_Silent_p.*492*|MAP3K7_ENST00000369332.3_Missense_Mutation_p.E531K	NM_145331.2	NP_663304.1	O43318	M3K7_HUMAN	mitogen-activated protein kinase kinase kinase 7	558					activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|histone H3 acetylation|I-kappaB phosphorylation|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytosol|endosome membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	28		all_cancers(76;6.4e-08)|Acute lymphoblastic leukemia(125;1.43e-09)|Prostate(29;9.32e-09)|all_hematologic(105;3.69e-06)|all_epithelial(107;0.000187)|Ovarian(999;0.0164)		OV - Ovarian serous cystadenocarcinoma(136;2.05e-11)|all cancers(137;3.25e-11)|GBM - Glioblastoma multiforme(226;0.0416)|BRCA - Breast invasive adenocarcinoma(108;0.0429)		TGGTCCTTTTCATCCTGGTCC	0.368000													15	58					0	0	1	0	0
MYH9	4627	broad.mit.edu	37	22	36681372	36681372	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr22:36681372C>A	ENST00000216181.5	-	38	5508	c.5278G>T	c.(5278-5280)Gac>Tac	p.D1760Y	MYH9_ENST00000475726.1_5'UTR	NM_002473.4	NP_002464.1	P35579	MYH9_HUMAN	myosin, heavy chain 9, non-muscle	1760					actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			NS(1)|breast(8)|central_nervous_system(3)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(16)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(3)	86						TTGATCTGGTCGATCTGCAGA	0.612000			T	ALK	ALCL		"""Deafness, autosomal dominant 17, Epstein syndrome, Fechtner syndrome, May-Hegglin anomaly, Sebastian syndrome"""		Hereditary Macrothrombocytopenia, MYH9-associated				35	47					2.47316e-13	2.69113e-13	1	1	0
CPXM1	56265	broad.mit.edu	37	20	2776987	2776987	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr20:2776987C>A	ENST00000380605.2	-	9	1212	c.1148G>T	c.(1147-1149)cGa>cTa	p.R383L		NM_001184699.1|NM_019609.4	NP_001171628.1|NP_062555.1	Q96SM3	CPXM1_HUMAN	carboxypeptidase X (M14 family), member 1	383					cell adhesion|proteolysis		metallocarboxypeptidase activity|zinc ion binding			endometrium(5)|kidney(5)|large_intestine(8)|lung(17)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						TGGGTTCCCTCGCAGGAACTC	0.627000													7	51					0.000157383	0.000163849	1	1	0
ZNF763	284390	broad.mit.edu	37	19	12089721	12089721	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:12089721C>G	ENST00000343949.5	+	4	1146	c.991C>G	c.(991-993)Ctt>Gtt	p.L331V	ZNF763_ENST00000590798.1_Missense_Mutation_p.L348V|ZNF763_ENST00000538752.1_Missense_Mutation_p.L348V|ZNF763_ENST00000358987.3_Missense_Mutation_p.L328V|ZNF763_ENST00000545530.1_Missense_Mutation_p.L206V	NM_001012753.1	NP_001012771.1			zinc finger protein 763											central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(9)	15						CAGATCCTATCTTAGACATAA	0.408000													9	68					0	0	1	0	0
GMFG	9535	broad.mit.edu	37	19	39819122	39819122	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:39819122G>A	ENST00000597595.1	-	7	632	c.424C>T	c.(424-426)Cgt>Tgt	p.R142C	GMFG_ENST00000598034.1_3'UTR|GMFG_ENST00000594700.1_Missense_Mutation_p.R73C|GMFG_ENST00000602185.1_Missense_Mutation_p.R93C|GMFG_ENST00000253054.8_Missense_Mutation_p.R109C|GMFG_ENST00000601387.1_Missense_Mutation_p.R101C|GMFG_ENST00000600322.1_Missense_Mutation_p.R109C|GMFG_ENST00000595636.1_3'UTR	NM_004877.2	NP_004868.1	O60234	GMFG_HUMAN	glia maturation factor, gamma	142					protein phosphorylation	intracellular	actin binding|enzyme activator activity|growth factor activity|protein kinase inhibitor activity			breast(1)|large_intestine(2)|liver(2)|lung(3)|skin(1)|stomach(1)	10	all_cancers(60;2.5e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.15e-27)|all cancers(26;1.3e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			AGAGATCAACGAAAGAAAGAC	0.498000											OREG0025458	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	57					0	0	1	0	0
CORO1B	57175	broad.mit.edu	37	11	67207599	67207599	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:67207599C>G	ENST00000393893.1	-	9	1100	c.997G>C	c.(997-999)Gag>Cag	p.E333Q	CORO1B_ENST00000341356.5_Missense_Mutation_p.E333Q|CORO1B_ENST00000539724.1_Intron	NM_001018070.2	NP_001018080.1	Q9BR76	COR1B_HUMAN	coronin, actin binding protein, 1B	333					actin cytoskeleton organization	actin cytoskeleton|cytoplasm	actin filament binding			cervix(1)|endometrium(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)	13			BRCA - Breast invasive adenocarcinoma(15;3.26e-06)			CGGGCGATCTCGCACTTGCTG	0.622000													9	35					0	0	1	0	0
C1orf131	128061	broad.mit.edu	37	1	231374697	231374697	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:231374697G>T	ENST00000318906.2	-	2	384	c.356C>A	c.(355-357)tCt>tAt	p.S119Y	C1orf131_ENST00000366649.2_Missense_Mutation_p.S119Y|C1orf131_ENST00000366651.3_Missense_Mutation_p.S119Y|C1orf131_ENST00000471936.1_5'UTR			Q8NDD1	CA131_HUMAN	chromosome 1 open reading frame 131	119										breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(1)	8	Breast(184;0.0871)	all_cancers(173;0.2)|Prostate(94;0.183)				CTTTAGGGAAGAGGGAGGAAC	0.453000													20	40					8.10497e-08	8.55821e-08	1	1	0
PLP2	5355	broad.mit.edu	37	X	49028421	49028421	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:49028421G>A	ENST00000376327.5	+	1	149	c.74G>A	c.(73-75)gGa>gAa	p.G25E	PLP2_ENST00000376322.3_Missense_Mutation_p.G25E	NM_002668.2	NP_002659.1	Q04941	PLP2_HUMAN	proteolipid protein 2 (colonic epithelium-enriched)	25	MARVEL.				chemotaxis|cytokine-mediated signaling pathway	endoplasmic reticulum membrane|integral to membrane|membrane fraction|plasma membrane	chemokine binding|ion transmembrane transporter activity			endometrium(3)|large_intestine(1)|lung(6)|urinary_tract(3)	13						ACTCGAAAGGGAATCCTCCTG	0.642000													4	24					0	0	1	0	0
ZNF286B	729288	broad.mit.edu	37	17	18566063	18566063	+	Silent	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr17:18566063G>C	ENST00000545289.1	-	5	1006	c.756C>G	c.(754-756)ctC>ctG	p.L252L	ZNF286B_ENST00000285274.5_3'UTR	NM_001145045.1	NP_001138517.1	P0CG31	Z286B_HUMAN	zinc finger protein 286B	252					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|lung(1)	2						GGCAGGTGAAGAGTTCACCAC	0.358000													15	25					0	0	1	0	0
CCDC157	550631	broad.mit.edu	37	22	30772606	30772606	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr22:30772606G>T	ENST00000405659.1	+	12	2840	c.2131G>T	c.(2131-2133)Gag>Tag	p.E711*	CCDC157_ENST00000338306.3_Nonsense_Mutation_p.E711*|RP1-130H16.16_ENST00000332468.4_RNA			Q569K6	CC157_HUMAN	coiled-coil domain containing 157	711										central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(5)|skin(3)|upper_aerodigestive_tract(1)	15						GTCCTTGCTGGAGGGTGTGAC	0.647000													18	57					5.03518e-11	5.40567e-11	1	1	0
XIRP2	129446	broad.mit.edu	37	2	168101632	168101632	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:168101632G>A	ENST00000409195.1	+	9	3819	c.3730G>A	c.(3730-3732)Gaa>Aaa	p.E1244K	XIRP2_ENST00000409273.1_Missense_Mutation_p.E1022K|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.E1244K|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409756.2_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1069					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GTGGCTTTTTGAAAACCAACC	0.348000													6	37					0	0	1	0	0
PGAM2	5224	broad.mit.edu	37	7	44105092	44105092	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:44105092C>T	ENST00000297283.3	-	1	94	c.37G>A	c.(37-39)Gag>Aag	p.E13K	AC017116.11_ENST00000445938.1_RNA	NM_000290.3	NP_000281.2	P15259	PGAM2_HUMAN	phosphoglycerate mutase 2 (muscle)	13					gluconeogenesis|glycolysis|striated muscle contraction	cytosol	2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity			large_intestine(2)|lung(4)|ovary(1)|stomach(1)	8						CATGTGCTCTCGCCGTGCCGG	0.622000													14	40					0	0	1	0	0
ZNRD1-AS1	80862	broad.mit.edu	37	6	29977359	29977359	+	RNA	SNP	G	G	A	rs3831361	by1000genomes	TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:29977359G>A	ENST00000376797.3	-	0	731				ZNRD1-AS1_ENST00000420251.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA|ZNRD1-AS1_ENST00000448093.1_RNA|HLA-J_ENST00000462773.1_RNA																							ATTTGTTCATGCCTTCCCTTT	0.453000													5	41					0	0	1	0	0
PUM1	9698	broad.mit.edu	37	1	31465481	31465481	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:31465481G>C	ENST00000373747.3	-	7	1013	c.914C>G	c.(913-915)tCt>tGt	p.S305C	PUM1_ENST00000424085.2_Intron|PUM1_ENST00000373741.4_Missense_Mutation_p.S341C|PUM1_ENST00000423018.2_Missense_Mutation_p.S209C|PUM1_ENST00000426105.2_Missense_Mutation_p.S305C|PUM1_ENST00000373742.2_Missense_Mutation_p.S245C|PUM1_ENST00000257075.5_Missense_Mutation_p.S305C|PUM1_ENST00000440538.2_Missense_Mutation_p.S305C	NM_001020658.1	NP_001018494.1	Q14671	PUM1_HUMAN	pumilio RNA-binding family member 1	305					cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding	p.S305F(1)		breast(1)|central_nervous_system(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(17)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		TTCATTAGCAGAGTTCTGGCA	0.493000													39	96					0	0	1	0	0
TKT	7086	broad.mit.edu	37	3	53275178	53275178	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:53275178G>A	ENST00000462138.1	-	3	397	c.309C>T	c.(307-309)atC>atT	p.I103I	TKT_ENST00000296289.6_Silent_p.I56I|TKT_ENST00000423516.1_Silent_p.I103I|TKT_ENST00000423525.2_Silent_p.I103I			P29401	TKT_HUMAN	transketolase	103					energy reserve metabolic process|xylulose biosynthetic process	cytosol	protein binding|transketolase activity			endometrium(5)|large_intestine(4)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	17		Prostate(884;0.0959)		BRCA - Breast invasive adenocarcinoma(193;0.000159)|OV - Ovarian serous cystadenocarcinoma(275;0.000314)|Kidney(197;0.00178)|KIRC - Kidney renal clear cell carcinoma(197;0.00201)	Thiamine(DB00152)	AGTCGGAGCTGATCTTCCTCA	0.637000													15	25					0	0	1	0	0
HECTD4	283450	broad.mit.edu	37	12	112617073	112617073	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:112617073C>G	ENST00000550722.1	-	63	11073	c.10678G>C	c.(10678-10680)Gag>Cag	p.E3560Q	HECTD4_ENST00000377560.5_Missense_Mutation_p.E3534Q|HECTD4_ENST00000430131.2_Missense_Mutation_p.E3284Q	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		TTGATCTGCTCTTTGCTAAGA	0.532000													23	17					0	0	1	0	0
SBNO1	55206	broad.mit.edu	37	12	123820972	123820972	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:123820972C>G	ENST00000420886.2	-	5	717	c.718G>C	c.(718-720)Gaa>Caa	p.E240Q	SBNO1_ENST00000267176.4_Missense_Mutation_p.E239Q|SBNO1_ENST00000602398.1_Missense_Mutation_p.E240Q|SBNO1_ENST00000602750.1_Missense_Mutation_p.E239Q	NM_001167856.1	NP_001161328.1	A3KN83	SBNO1_HUMAN	strawberry notch homolog 1 (Drosophila)	240							ATP binding|DNA binding|hydrolase activity			NS(2)|breast(6)|cervix(2)|endometrium(8)|kidney(3)|large_intestine(11)|lung(18)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(2)	62	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		GCATAGGTTTCTGCATGACCC	0.363000													7	30					0	0	1	0	0
DENND4A	10260	broad.mit.edu	37	15	66044729	66044729	+	Silent	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr15:66044729G>C	ENST00000443035.3	-	4	764	c.549C>G	c.(547-549)ctC>ctG	p.L183L	DENND4A_ENST00000431932.2_Silent_p.L183L	NM_001144823.1	NP_001138295.1	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A	183	MABP.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(11)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	51						TACTGTTATTGAGATTCTTGT	0.333000													6	37					0	0	1	0	0
ATP2B4	493	broad.mit.edu	37	1	203652429	203652429	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:203652429C>T	ENST00000357681.5	+	2	1219	c.96C>T	c.(94-96)ctC>ctT	p.L32L	ATP2B4_ENST00000367218.3_Silent_p.L32L|ATP2B4_ENST00000391954.2_Silent_p.L32L|ATP2B4_ENST00000367219.3_Silent_p.L32L|ATP2B4_ENST00000341360.2_Silent_p.L32L	NM_001684.4	NP_001675.3	P23634	AT2B4_HUMAN	ATPase, Ca++ transporting, plasma membrane 4	32					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding	p.L32L(2)		NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(20)|ovary(2)|prostate(6)|skin(1)|stomach(1)|urinary_tract(3)	56	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			TGAGGAAGCTCATGGAGCTGC	0.522000													43	94					0	0	1	0	0
WWP2	11060	broad.mit.edu	37	16	69969881	69969881	+	Silent	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr16:69969881C>G	ENST00000359154.2	+	18	2069	c.1968C>G	c.(1966-1968)gtC>gtG	p.V656V	WWP2_ENST00000568684.1_Silent_p.V217V|WWP2_ENST00000448661.1_Silent_p.V656V|WWP2_ENST00000356003.2_Silent_p.V656V|WWP2_ENST00000542271.1_Silent_p.V540V|WWP2_ENST00000544162.1_3'UTR	NM_001270454.1|NM_007014.4	NP_001257383.1|NP_008945.2	O00308	WWP2_HUMAN	WW domain containing E3 ubiquitin protein ligase 2	656	HECT.				entry of virus into host cell|negative regulation of protein transport|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transporter activity|proteasomal ubiquitin-dependent protein catabolic process|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	RNA polymerase II transcription factor binding|ubiquitin-protein ligase activity			breast(4)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						ACTCCATTGTCTGGATCAAGT	0.542000													15	37					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140449173	140449173	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:140449173G>A	ENST00000288602.6	-	16	1966	c.1906C>T	c.(1906-1908)Cag>Tag	p.Q636*		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	636	Protein kinase.				activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.Q636E(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	ACATCTGACTGAAAGCTGTAT	0.333000		61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				11	29					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55538163	55538163	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr8:55538163C>G	ENST00000220676.1	+	4	1869	c.1721C>G	c.(1720-1722)tCa>tGa	p.S574*		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	574					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TCAAATAACTCAATTGTGGAG	0.348000													9	62					0	0	1	0	0
HNRNPUL1	11100	broad.mit.edu	37	19	41810097	41810097	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:41810097G>C	ENST00000392006.3	+	13	2366	c.2193G>C	c.(2191-2193)aaG>aaC	p.K731N	HNRNPUL1_ENST00000602130.1_Missense_Mutation_p.K731N|HNRNPUL1_ENST00000352456.3_Missense_Mutation_p.K631N|HNRNPUL1_ENST00000378215.4_Missense_Mutation_p.K617N|HNRNPUL1_ENST00000263367.3_Missense_Mutation_p.K642N|HNRNPUL1_ENST00000595018.1_Missense_Mutation_p.K631N|HNRNPUL1_ENST00000593587.1_Missense_Mutation_p.K631N	NM_007040.3	NP_008971.2	Q9BUJ2	HNRL1_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 1	731	Necessary for interaction with TP53.|Pro-rich.				nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	29						CCTACAATAAGAACAGCAACA	0.612000													13	40					0	0	1	0	0
FGD4	121512	broad.mit.edu	37	12	32751511	32751511	+	Silent	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:32751511C>G	ENST00000427716.2	+	5	1105	c.681C>G	c.(679-681)ctC>ctG	p.L227L	FGD4_ENST00000266482.3_5'UTR|FGD4_ENST00000531134.1_Silent_p.L312L|FGD4_ENST00000381025.3_5'UTR|FGD4_ENST00000546442.1_Silent_p.L134L|FGD4_ENST00000534526.2_Silent_p.L364L|FGD4_ENST00000525053.1_Silent_p.L339L	NM_139241.2	NP_640334.2	Q96M96	FGD4_HUMAN	FYVE, RhoGEF and PH domain containing 4	227	DH.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|filopodium|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(1)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	27	Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)					GACTTGACCTCTTAGATCAGG	0.303000													7	154					0	0	1	0	0
COL24A1	255631	broad.mit.edu	37	1	86488240	86488240	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:86488240G>T	ENST00000370571.2	-	17	2549	c.2183C>A	c.(2182-2184)cCc>cAc	p.P728H	COL24A1_ENST00000436319.1_Missense_Mutation_p.P728H	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	728					cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		AGGATACCCGGGTTCTCCTAG	0.343000													20	51					2.21704e-12	2.39888e-12	1	1	0
NOC3L	64318	broad.mit.edu	37	10	96098452	96098452	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr10:96098452C>G	ENST00000371361.3	-	18	2104	c.2004G>C	c.(2002-2004)caG>caC	p.Q668H	NOC3L_ENST00000371350.1_Missense_Mutation_p.Q668H|NOC3L_ENST00000543788.1_Missense_Mutation_p.Q406H	NM_022451.9	NP_071896.8	Q8WTT2	NOC3L_HUMAN	nucleolar complex associated 3 homolog (S. cerevisiae)	668						nuclear speck|nucleolus	binding			endometrium(3)|large_intestine(17)|lung(5)|ovary(1)|skin(2)|stomach(1)	29		Colorectal(252;0.0897)				CTCCACTTCCCTGAGATTCAC	0.433000													10	31					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151154611	151154611	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:151154611C>T	ENST00000282466.3	-	6	7737	c.7738G>A	c.(7738-7740)Gga>Aga	p.G2580R	MED12L_ENST00000474524.1_3'UTR|IGSF10_ENST00000495443.1_5'UTR	NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	2580	Ig-like C2-type 12.				cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TGCTCACTTCCATGTGTCCTC	0.498000													18	66					0	0	1	0	0
ZIM2	23619	broad.mit.edu	37	19	57286545	57286545	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:57286545G>A	ENST00000391708.3	-	12	1637	c.1095C>T	c.(1093-1095)ttC>ttT	p.F365F	AC006115.3_ENST00000594400.1_RNA|ZIM2_ENST00000593711.1_Silent_p.F365F|AC006115.3_ENST00000597946.1_RNA|ZIM2_ENST00000599935.1_Silent_p.F365F|ZIM2_ENST00000601070.1_Silent_p.F365F|AC006115.3_ENST00000595954.1_RNA|ZIM2_ENST00000221722.5_Silent_p.F365F	NM_001146326.1|NM_001146327.1	NP_001139798.1|NP_001139799.1			zinc finger, imprinted 2											NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(20)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0314)		GCATGAGATAGAAGGCTTCAG	0.473000													66	94					0	0	1	0	0
PTPRF	5792	broad.mit.edu	37	1	44083518	44083518	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:44083518G>A	ENST00000359947.4	+	25	4647	c.4307G>A	c.(4306-4308)aGg>aAg	p.R1436K	PTPRF_ENST00000372414.3_Missense_Mutation_p.R1436K|PTPRF_ENST00000422171.2_Missense_Mutation_p.R795K|PTPRF_ENST00000372413.3_Missense_Mutation_p.R1427K|PTPRF_ENST00000496447.1_3'UTR|PTPRF_ENST00000438120.1_Missense_Mutation_p.R1427K	NM_002840.3	NP_002831.2	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	1436	Tyrosine-protein phosphatase 1.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(24)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)	72	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GATTTCTGGAGGATGGTGTGG	0.617000													4	34					0	0	1	0	0
TBATA	219793	broad.mit.edu	37	10	72541683	72541683	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr10:72541683G>A	ENST00000299290.1	-	4	540	c.151C>T	c.(151-153)Cgg>Tgg	p.R51W	TBATA_ENST00000545575.1_Missense_Mutation_p.R41W|TBATA_ENST00000456372.2_Missense_Mutation_p.R51W	NM_152710.2	NP_689923			thymus, brain and testes associated									p.R51R(2)									CGGCGGATCCGCTCGAAATCC	0.597000													25	59					0	0	1	0	0
PCDHB12	56124	broad.mit.edu	37	5	140590576	140590576	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr5:140590576G>A	ENST00000239450.2	+	1	2286	c.2097G>A	c.(2095-2097)tcG>tcA	p.S699S	PCDHB12_ENST00000541609.1_Silent_p.S362S	NM_018932.3	NP_061755.1	Q9Y5F1	PCDBC_HUMAN		699					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(10)|large_intestine(17)|lung(38)|ovary(3)|pancreas(1)|prostate(2)|skin(7)|stomach(1)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAGTGTCGTCGCTCTTCCTCT	0.706000													26	71					0	0	1	0	0
PRDM13	59336	broad.mit.edu	37	6	100057121	100057121	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:100057121C>G	ENST00000369215.4	+	3	640	c.335C>G	c.(334-336)tCt>tGt	p.S112C		NM_021620.3	NP_067633.2	Q9H4Q3	PRD13_HUMAN	PR domain containing 13	112	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(9)|prostate(1)	17		all_cancers(76;1.64e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0128)|Colorectal(196;0.069)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0598)		GTGTGGTATTCTAACTCCTTG	0.537000													7	12					0	0	1	0	0
WFDC6	140870	broad.mit.edu	37	20	44167971	44167971	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr20:44167971C>G	ENST00000600168.1	-	1	163	c.76G>C	c.(76-78)Gaa>Caa	p.E26Q	WFDC6_ENST00000372670.3_Missense_Mutation_p.E26Q|EPPIN_ENST00000555685.1_Intron|EPPIN-WFDC6_ENST00000504988.1_Intron					WAP four-disulfide core domain 6											breast(1)|kidney(1)|large_intestine(2)|lung(2)	6		Myeloproliferative disorder(115;0.0122)				AGGATGCCTTCAGCGTGCCCA	0.493000													13	48					0	0	1	0	0
OR2M2	391194	broad.mit.edu	37	1	248344279	248344279	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:248344279C>T	ENST00000359682.2	+	1	992	c.992C>T	c.(991-993)tCc>tTc	p.S331F		NM_001004688.1	NP_001004688.1	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M, member 2	331					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(45)|ovary(3)|prostate(1)|skin(3)	70	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TTTCTAATATCCATCTTTTTC	0.313000													38	81					0	0	1	0	0
MRS2	57380	broad.mit.edu	37	6	24409759	24409759	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:24409759G>C	ENST00000378386.3	+	4	465	c.372G>C	c.(370-372)atG>atC	p.M124I	MRS2_ENST00000443868.2_Missense_Mutation_p.M124I|MRS2_ENST00000483634.1_Intron|MRS2_ENST00000535061.1_Intron|MRS2_ENST00000274747.7_Intron|MRS2_ENST00000378353.1_Missense_Mutation_p.M124I|MRS2_ENST00000543597.1_5'UTR	NM_020662.2	NP_065713.1	Q9HD23	MRS2_HUMAN	MRS2 magnesium transporter	124					ion transport	integral to membrane|mitochondrial inner membrane				breast(1)|endometrium(2)|large_intestine(2)|lung(5)|skin(1)|stomach(1)	12						AGCATGTAATGAGTATCACAG	0.308000													16	20					0	0	1	0	0
AQP1	358	broad.mit.edu	37	7	30951862	30951862	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:30951862C>G	ENST00000311813.4	+	1	393	c.338C>G	c.(337-339)tCa>tGa	p.S113*	AQP1_ENST00000434909.2_Nonsense_Mutation_p.S173*|AQP1_ENST00000509504.1_Nonsense_Mutation_p.S290*	NM_198098.2	NP_932766.1			aquaporin 1											kidney(1)|large_intestine(2)|lung(9)	12		Melanoma(862;0.16)				GCCATCCTCTCAGGCATCACC	0.617000													35	58					0	0	1	0	0
MAPK10	5602	broad.mit.edu	37	4	87028452	87028452	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr4:87028452C>A	ENST00000395169.3	-	5	896	c.176G>T	c.(175-177)aGa>aTa	p.R59I	MAPK10_ENST00000395166.1_Missense_Mutation_p.R59I|MAPK10_ENST00000513839.1_5'UTR|MAPK10_ENST00000395157.3_5'UTR|MAPK10_ENST00000395161.2_Missense_Mutation_p.R97I|MAPK10_ENST00000395160.3_5'UTR|MAPK10_ENST00000449047.2_5'UTR|MAPK10_ENST00000359221.3_Missense_Mutation_p.R97I|MAPK10_ENST00000361569.2_Missense_Mutation_p.R97I	NM_138980.2|NM_138982.2	NP_620446.1|NP_620448.1	P53779	MK10_HUMAN	mitogen-activated protein kinase 10	97					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|MAP kinase kinase activity|protein binding			breast(1)|central_nervous_system(1)|stomach(1)	3		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.243)		OV - Ovarian serous cystadenocarcinoma(123;0.002)		CTGAAAGGGTCTGCTGAGCTT	0.428000													31	41					1.68575e-08	1.78787e-08	1	1	0
LINGO3	645191	broad.mit.edu	37	19	2290278	2290278	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:2290278C>A	ENST00000585527.1	-	1	1745	c.1498G>T	c.(1498-1500)Gag>Tag	p.E500*	LINGO3_ENST00000404279.1_Nonsense_Mutation_p.E500*			P0C6S8	LIGO3_HUMAN	leucine rich repeat and Ig domain containing 3	500						integral to membrane				lung(1)|urinary_tract(1)	2						GCGGCCGGCTCGGGGCGCACG	0.736000													4	13					0.00909568	0.00922986	1	1	0
EFHD1	80303	broad.mit.edu	37	2	233546331	233546331	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:233546331G>C	ENST00000264059.3	+	4	1099	c.622G>C	c.(622-624)Gag>Cag	p.E208Q	EFHD1_ENST00000409708.1_Missense_Mutation_p.E96Q|EFHD1_ENST00000410095.1_Missense_Mutation_p.E96Q|EFHD1_ENST00000409613.1_Missense_Mutation_p.E112Q	NM_025202.3	NP_079478.1	Q9BUP0	EFHD1_HUMAN	EF-hand domain family, member D1	208							calcium ion binding|protein binding			NS(1)|breast(1)|large_intestine(2)|lung(3)	7		all_hematologic(139;0.0123)|Acute lymphoblastic leukemia(138;0.0182)|Breast(86;0.0199)|Renal(207;0.025)		Epithelial(121;2.08e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000383)|LUSC - Lung squamous cell carcinoma(224;0.00825)|Lung(119;0.0101)		GTTTGAAGCAGAGTTGAAAGC	0.547000													26	71					0	0	1	0	0
ERCC2	2068	broad.mit.edu	37	19	45857993	45857993	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:45857993C>G	ENST00000391945.4	-	17	1737	c.1660G>C	c.(1660-1662)Gag>Cag	p.E554Q	ERCC2_ENST00000391944.3_Missense_Mutation_p.E476Q	NM_000400.3	NP_000391.1	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 2	554	Mediates interaction with MMS19.				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			large_intestine(4)|lung(2)|ovary(1)|pancreas(1)|stomach(1)	9		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		CGTACCTGCTCATACCAGGAG	0.602000			"""Mis, N, F, S"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				41	45					0	0	1	0	0
C12orf40	283461	broad.mit.edu	37	12	40037665	40037665	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:40037665G>C	ENST00000324616.5	+	3	302	c.148G>C	c.(148-150)Gac>Cac	p.D50H	C12orf40_ENST00000398716.1_5'UTR|C12orf40_ENST00000405531.3_Missense_Mutation_p.D50H	NM_001031748.2	NP_001026918.2	Q86WS4	CL040_HUMAN	chromosome 12 open reading frame 40	50										breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(6)|prostate(1)|skin(2)	38						TGTCAGCTTAGACATTCTTAA	0.294000													27	71					0	0	1	0	0
TONSL	4796	broad.mit.edu	37	8	145666128	145666128	+	Silent	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr8:145666128C>G	ENST00000409379.3	-	9	1166	c.1137G>C	c.(1135-1137)ctG>ctC	p.L379L		NM_013432.4	NP_038460.4	Q96HA7	TONSL_HUMAN	tonsoku-like, DNA repair protein	379					cytoplasmic sequestering of transcription factor|double-strand break repair via homologous recombination|replication fork processing	cytoplasm|nuclear replication fork	histone binding|transcription corepressor activity			biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|lung(14)|ovary(3)|prostate(1)|skin(1)	26						TGCGCAGCCTCAGTTCCTCCT	0.642000													12	35					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152187670	152187670	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:152187670C>G	ENST00000368801.2	-	3	6510	c.6435G>C	c.(6433-6435)agG>agC	p.R2145S	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	2145					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTCGTTCACCCCTAGATGACT	0.582000													16	779					0	0	1	0	0
TRMT2A	27037	broad.mit.edu	37	22	20100205	20100205	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr22:20100205C>G	ENST00000252136.7	-	12	2147	c.1759G>C	c.(1759-1761)Gag>Cag	p.E587Q	TRMT2A_ENST00000403707.3_Missense_Mutation_p.E587Q|TRMT2A_ENST00000439169.2_Missense_Mutation_p.E605Q|TRMT2A_ENST00000404751.3_3'UTR	NM_001257994.1|NM_022727.5|NM_182984.4	NP_001244923.1|NP_073564.3|NP_892029.2	Q8IZ69	TRM2A_HUMAN	tRNA methyltransferase 2 homolog A (S. cerevisiae)	587					RNA processing		nucleotide binding|RNA binding|RNA methyltransferase activity			breast(2)|endometrium(2)|lung(5)	9						TCCACCCTCTCAAACAGGATG	0.617000													5	39					0	0	1	0	0
SLITRK3	22865	broad.mit.edu	37	3	164906398	164906398	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:164906398C>T	ENST00000475390.1	-	2	2664	c.2221G>A	c.(2221-2223)Gag>Aag	p.E741K	SLITRK3_ENST00000241274.3_Missense_Mutation_p.E741K			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	741						integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						GGGATGTACTCATACACATGA	0.582000										HNSCC(40;0.11)			13	47					0	0	1	0	0
ANKRD26	22852	broad.mit.edu	37	10	27294537	27294537	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr10:27294537C>G	ENST00000376087.4	-	34	5280	c.5115G>C	c.(5113-5115)aaG>aaC	p.K1705N	ANKRD26_ENST00000376070.3_Missense_Mutation_p.K1262N|ANKRD26_ENST00000436985.2_Missense_Mutation_p.K1721N	NM_001256053.1|NM_014915.2	NP_001242982.1|NP_055730.2	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	1704						centrosome				breast(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|urinary_tract(2)	70						TATAATTTTTCTTTAAAACCT	0.284000													20	136					0	0	1	0	0
MCTP1	79772	broad.mit.edu	37	5	94206145	94206145	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr5:94206145C>G	ENST00000515393.1	-	16	2292	c.2293G>C	c.(2293-2295)Gag>Cag	p.E765Q	MCTP1_ENST00000505078.1_Missense_Mutation_p.E281Q|MCTP1_ENST00000429576.2_Missense_Mutation_p.E498Q|MCTP1_ENST00000312216.8_Missense_Mutation_p.E544Q|MCTP1_ENST00000505208.1_Missense_Mutation_p.E544Q	NM_024717.4	NP_078993.4	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1	765					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(3)|large_intestine(13)|liver(2)|lung(13)|ovary(2)|skin(4)|stomach(2)|urinary_tract(1)	41		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		CTGTTTTCCTCTTCAATGTAC	0.313000													15	27					0	0	1	0	0
COG5	10466	broad.mit.edu	37	7	106871137	106871137	+	Splice_Site	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:106871137C>G	ENST00000393603.2	-	19	2456		c.e19-1		COG5_ENST00000297135.3_Splice_Site|COG5_ENST00000347053.3_Splice_Site	NM_001161520.1	NP_001154992.1	Q9UP83	COG5_HUMAN	component of oligomeric golgi complex 5						intra-Golgi vesicle-mediated transport|protein transport	cytosol|Golgi membrane|Golgi transport complex|nucleus	protein binding			breast(3)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(17)|ovary(2)|skin(4)|stomach(1)	40						CCAACTCCATCTGAAATATTA	0.388000													34	53					0	0	1	0	0
CLP1	10978	broad.mit.edu	37	11	57427062	57427062	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:57427062G>C	ENST00000533682.1	+	2	839	c.114G>C	c.(112-114)ttG>ttC	p.L38F	CLP1_ENST00000529430.1_Missense_Mutation_p.L49F|CLP1_ENST00000302731.4_Missense_Mutation_p.L38F|CLP1_ENST00000525602.1_Missense_Mutation_p.L38F			Q92989	CLP1_HUMAN	cleavage and polyadenylation factor I subunit 1	38					mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|siRNA loading onto RISC involved in RNA interference|targeting of mRNA for destruction involved in RNA interference|termination of RNA polymerase II transcription|tRNA splicing, via endonucleolytic cleavage and ligation	nucleoplasm|tRNA-intron endonuclease complex	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|stomach(1)	15						TGGAGTTGTTGACTGGCATGG	0.468000													7	36					0	0	1	0	0
ATAD3B	83858	broad.mit.edu	37	1	1422041	1422041	+	Missense_Mutation	SNP	C	C	T	rs139682140	byFrequency	TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:1422041C>T	ENST00000308647.7	+	11	1323	c.1207C>T	c.(1207-1209)Cgg>Tgg	p.R403W		NM_031921.4	NP_114127.3	Q5T9A4	ATD3B_HUMAN	ATPase family, AAA domain containing 3B	403							ATP binding|nucleoside-triphosphatase activity			endometrium(2)|large_intestine(1)|lung(3)|ovary(1)|skin(2)|urinary_tract(1)	10	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		CAATACCAGCCGGCGCGGGTG	0.672000													6	24					0	0	1	0	0
ZBTB33	10009	broad.mit.edu	37	X	119387502	119387502	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:119387502T>C	ENST00000326624.2	+	2	460	c.232T>C	c.(232-234)Ttt>Ctt	p.F78L	ZBTB33_ENST00000557385.1_Missense_Mutation_p.F78L	NM_006777.3	NP_006768.1	Q86T24	KAISO_HUMAN	zinc finger and BTB domain containing 33	78	BTB.|Interaction with NCOR1.|Self-association (By similarity).				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|nucleolus|plasma membrane	DNA binding|protein binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(6)|large_intestine(6)|lung(5)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	26						AGCAGAGATCTTTGCAGAAAT	0.363000													21	137					0	0	1	0	0
OR4A47	403253	broad.mit.edu	37	11	48510813	48510813	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:48510813C>T	ENST00000446524.1	+	1	545	c.469C>T	c.(469-471)Caa>Taa	p.Q157*		NM_001005512.2	NP_001005512.2	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A, member 47	157					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(18)|ovary(1)|skin(1)|urinary_tract(2)	29						CTCAGTATTTCAACTTAGCAT	0.433000													29	103					0	0	1	0	0
TCTN1	79600	broad.mit.edu	37	12	111078196	111078196	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:111078196C>G	ENST00000551590.1	+	8	1008	c.852C>G	c.(850-852)atC>atG	p.I284M	TCTN1_ENST00000551555.2_3'UTR|TCTN1_ENST00000397655.3_Missense_Mutation_p.I270M|TCTN1_ENST00000377654.3_Missense_Mutation_p.I106M|HVCN1_ENST00000548312.1_Intron|TCTN1_ENST00000397659.4_Missense_Mutation_p.I284M			Q2MV58	TECT1_HUMAN	tectonic family member 1	284					multicellular organismal development	extracellular region				NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(9)|urinary_tract(1)	15						AGGTCCCTATCACTGTTCAGT	0.502000													12	44					0	0	1	0	0
LSM3	27258	broad.mit.edu	37	3	14223150	14223150	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:14223150G>A	ENST00000306024.3	+	2	615	c.112G>A	c.(112-114)Gag>Aag	p.E38K		NM_014463.2	NP_055278.1	P62310	LSM3_HUMAN	LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)	38					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	catalytic step 2 spliceosome|cytosol	protein binding|RNA binding			central_nervous_system(1)|large_intestine(2)|ovary(1)	4						AAATGACCGAGAGCTTCGAGG	0.418000													33	156					0	0	1	0	0
ZNF550	162972	broad.mit.edu	37	19	58059268	58059268	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:58059268G>C	ENST00000325134.5	-	3	404	c.248C>G	c.(247-249)tCt>tGt	p.S83C	ZNF549_ENST00000594943.1_Intron|ZNF550_ENST00000506609.2_Missense_Mutation_p.S74C|ZNF549_ENST00000602149.1_Intron|ZNF550_ENST00000457177.1_Missense_Mutation_p.S115C|ZNF550_ENST00000601415.1_Intron			Q7Z398	ZN550_HUMAN	zinc finger protein 550	115	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(1)|lung(4)|prostate(1)	7		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TGAGGTTGAAGATTCCAGAGT	0.527000													84	253					0	0	1	0	0
SPINK8	646424	broad.mit.edu	37	3	48361094	48361094	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:48361094C>G	ENST00000434006.1	-	3	131	c.132G>C	c.(130-132)aaG>aaC	p.K44N		NM_001080525.1	NP_001073994.1	P0C7L1	ISK8_HUMAN	serine peptidase inhibitor, Kazal type 8 (putative)	44	Kazal-like.					extracellular region	serine-type endopeptidase inhibitor activity			autonomic_ganglia(1)|kidney(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		TATTTACATTCTTGAGGCATT	0.458000													13	34					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179464414	179464414	+	Silent	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:179464414G>C	ENST00000589042.1	-	289	56438	c.56214C>G	c.(56212-56214)gtC>gtG	p.V18738V	TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Silent_p.V16170V|TTN_ENST00000342175.6_Silent_p.V9865V|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN_ENST00000359218.5_Silent_p.V9798V|TTN_ENST00000460472.2_Silent_p.V9673V|TTN_ENST00000591111.1_Silent_p.V17097V|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000456053.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	17097	Fibronectin type-III 36.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCAGTTTGTTGACATGGGTGT	0.433000													40	63					0	0	1	0	0
KLHL41	10324	broad.mit.edu	37	2	170366373	170366373	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:170366373G>A	ENST00000284669.1	+	1	162	c.85G>A	c.(85-87)Gag>Aag	p.E29K	RP11-724O16.1_ENST00000513963.1_Intron|BBS5_ENST00000554017.1_Intron	NM_006063.2	NP_006054.2			kelch-like family member 41																		TCTCCTGGATGAGAAAAAATT	0.453000													25	111					0	0	1	0	0
ESF1	51575	broad.mit.edu	37	20	13755880	13755880	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr20:13755880C>G	ENST00000202816.1	-	4	1179	c.1072G>C	c.(1072-1074)Gat>Cat	p.D358H		NM_001276380.1|NM_016649.3	NP_001263309.1|NP_057733.2	Q9H501	ESF1_HUMAN	ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)	358					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm				endometrium(3)|kidney(5)|large_intestine(8)|lung(11)|ovary(2)|skin(1)|stomach(1)	31						TTTAATCTATCCCAGTCCATG	0.323000													15	118					0	0	1	0	0
SEPT9	10801	broad.mit.edu	37	17	75493399	75493399	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr17:75493399G>C	ENST00000329047.8	+	10	2334	c.1522G>C	c.(1522-1524)Gaa>Caa	p.E508Q	SEPT9_ENST00000427674.2_Missense_Mutation_p.E362Q|SEPT9_ENST00000591198.1_Missense_Mutation_p.E507Q|SEPT9_ENST00000585930.1_Missense_Mutation_p.E302Q|SEPT9_ENST00000431235.2_Missense_Mutation_p.E362Q|SEPT9_ENST00000591088.1_Missense_Mutation_p.E275Q|SEPT9_ENST00000427180.1_Missense_Mutation_p.E414Q|SEPT9_ENST00000592951.1_Missense_Mutation_p.E275Q|SEPT9_ENST00000423034.2_Missense_Mutation_p.E519Q|SEPT9_ENST00000427177.1_Missense_Mutation_p.E526Q|SEPT9_ENST00000588690.1_Missense_Mutation_p.E362Q|SEPT9_ENST00000541152.2_Missense_Mutation_p.E275Q|SEPT9_ENST00000449803.2_Missense_Mutation_p.E362Q|SEPT9_ENST00000590294.1_Missense_Mutation_p.E508Q	NM_006640.4	NP_006631.2	Q9UHD8	SEPT9_HUMAN	septin 9	526					cell cycle|cell division|protein heterooligomerization	microtubule|perinuclear region of cytoplasm|stress fiber	GTP binding|GTPase activity|protein binding	p.E508K(1)		autonomic_ganglia(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|prostate(2)	16			BRCA - Breast invasive adenocarcinoma(99;0.153)			TCTCCTAGTTGAAAACACCAC	0.582000													5	13					0	0	1	0	0
SCG2	7857	broad.mit.edu	37	2	224462539	224462539	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:224462539C>G	ENST00000305409.2	-	2	1694	c.1462G>C	c.(1462-1464)Gaa>Caa	p.E488Q		NM_003469.4	NP_003460.2	P13521	SCG2_HUMAN	secretogranin II	488					angiogenesis|endothelial cell migration|eosinophil chemotaxis|induction of positive chemotaxis|inflammatory response|MAPKKK cascade|negative regulation of apoptosis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|protein secretion	extracellular space|stored secretory granule	chemoattractant activity|cytokine activity			NS(1)|breast(1)|endometrium(1)|kidney(6)|large_intestine(10)|liver(1)|lung(16)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	44		Renal(207;0.0112)|Lung NSC(271;0.0185)|all_lung(227;0.0271)		Epithelial(121;8.16e-11)|all cancers(144;4.66e-08)|Lung(261;0.00714)|LUSC - Lung squamous cell carcinoma(224;0.008)		TGTCTGTTTTCAACATGTGGA	0.438000													12	88					0	0	1	0	0
KIAA1211L	343990	broad.mit.edu	37	2	99439386	99439386	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:99439386C>T	ENST00000397899.2	-	7	1681	c.1350G>A	c.(1348-1350)gaG>gaA	p.E450E		NM_207362.2	NP_997245.2			KIAA1211-like																		GGGGCCCCTTCTCCTCATCCG	0.726000													10	22					0	0	1	0	0
CLCN5	1184	broad.mit.edu	37	X	49854786	49854786	+	Silent	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:49854786G>T	ENST00000376088.3	+	13	2399	c.1758G>T	c.(1756-1758)cgG>cgT	p.R586R	CLCN5_ENST00000376091.3_Silent_p.R586R|CLCN5_ENST00000307367.2_Silent_p.R516R|CLCN5_ENST00000376108.3_Silent_p.R516R	NM_001127898.1|NM_001127899.1	NP_001121370.1|NP_001121371.1	P51795	CLCN5_HUMAN	chloride channel, voltage-sensitive 5	516	CBS 1.				excretion	apical part of cell|endosome membrane|Golgi membrane|integral to plasma membrane	antiporter activity|ATP binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(8)|ovary(2)|skin(1)	30	Ovarian(276;0.236)					GGGTGACTCGGATGACTGTTT	0.468000													45	189					2.43139e-17	2.67898e-17	1	1	0
PLA2R1	22925	broad.mit.edu	37	2	160869838	160869838	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:160869838G>A	ENST00000283243.7	-	10	1806	c.1600C>T	c.(1600-1602)Cga>Tga	p.R534*	PLA2R1_ENST00000392771.1_Nonsense_Mutation_p.R534*	NM_001195641.1|NM_007366.4	NP_001182570.1|NP_031392.3	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1, 180kDa	534	C-type lectin 3.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding		PLA2R1/RBMS1(2)	central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(17)|lung(20)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	60						TCAAAGCTTCGAAGGACTGTG	0.368000													11	43					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77641943	77641943	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr13:77641943G>A	ENST00000407578.2	-	71	12494	c.12228C>T	c.(12226-12228)agC>agT	p.S4076S	MYCBP2_ENST00000357337.6_Silent_p.S4038S|MYCBP2_ENST00000544440.2_Silent_p.S4038S	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	4038					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		CTCCTATGATGCTGGCCAGAC	0.413000													27	50					0	0	1	0	0
KCTD6	200845	broad.mit.edu	37	3	58487085	58487085	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:58487085C>G	ENST00000355076.6	+	2	1423	c.440C>G	c.(439-441)aCt>aGt	p.T147S	KCTD6_ENST00000490264.1_Missense_Mutation_p.T147S|KCTD6_ENST00000404589.3_Missense_Mutation_p.T147S	NM_153331.3	NP_699162.3	Q8NC69	KCTD6_HUMAN	potassium channel tetramerization domain containing 6	147						voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(1)|large_intestine(2)|lung(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(55;0.000177)|Kidney(10;0.00229)|KIRC - Kidney renal clear cell carcinoma(10;0.00258)|OV - Ovarian serous cystadenocarcinoma(275;0.148)		ACCATCACCACTAAGGTCCAT	0.423000													15	129					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195516459	195516459	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:195516459G>A	ENST00000463781.3	-	2	2451	c.1992C>T	c.(1990-1992)gtC>gtT	p.V664V	MUC4_ENST00000349607.4_Intron|MUC4_ENST00000475231.1_Silent_p.V664V|MUC4_ENST00000346145.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	669					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		CTGGGGTGGTGACTGTCTTGG	0.567000													54	47					0	0	1	0	0
LDOC1	23641	broad.mit.edu	37	X	140271168	140271168	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:140271168C>T	ENST00000370526.2	-	1	142	c.39G>A	c.(37-39)ctG>ctA	p.L13L	LDOC1_ENST00000460721.1_5'UTR	NM_012317.2	NP_036449.1	O95751	LDOC1_HUMAN	leucine zipper, down-regulated in cancer 1	13					negative regulation of cell proliferation	nucleus	protein binding			endometrium(6)|large_intestine(1)|lung(6)|ovary(1)	14	Acute lymphoblastic leukemia(192;7.65e-05)					GGTGCCGCATCAGGAGCGCGT	0.672000													6	6					0	0	1	0	0
UBE2H	7328	broad.mit.edu	37	7	129519417	129519417	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:129519417G>T	ENST00000355621.3	-	3	589	c.196C>A	c.(196-198)Cca>Aca	p.P66T	UBE2H_ENST00000473814.2_Missense_Mutation_p.P66T	NM_001202498.1|NM_003344.3	NP_001189427.1|NP_003335.1	P62256	UBE2H_HUMAN	ubiquitin-conjugating enzyme E2H	66					protein K11-linked ubiquitination|protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process		ATP binding|ubiquitin-protein ligase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(2)|skin(1)	10	Melanoma(18;0.0435)					CCTATAGATGGAGATTTGAAA	0.358000													21	108					5.35356e-11	5.74106e-11	1	1	0
TBC1D1	23216	broad.mit.edu	37	4	38097678	38097678	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr4:38097678G>C	ENST00000261439.4	+	14	2720	c.2365G>C	c.(2365-2367)Gac>Cac	p.D789H	TBC1D1_ENST00000508802.1_Missense_Mutation_p.D883H	NM_001253914.1|NM_001253915.1|NM_015173.3	NP_001240843.1|NP_001240844.1|NP_055988.2	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	789						nucleus	Rab GTPase activator activity			NS(1)|breast(3)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	36						AATTAAGTTTGACATGGAAAA	0.428000													13	47					0	0	1	0	0
PCYT1A	5130	broad.mit.edu	37	3	195965721	195965721	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:195965721G>A	ENST00000292823.2	-	10	1114	c.942C>T	c.(940-942)atC>atT	p.I314I	PCYT1A_ENST00000431016.1_Silent_p.I314I|PCYT1A_ENST00000419333.1_Silent_p.I314I	NM_005017.2	NP_005008.2	P49585	PCY1A_HUMAN	phosphate cytidylyltransferase 1, choline, alpha	314						cytosol|soluble fraction	choline-phosphate cytidylyltransferase activity			cervix(1)|endometrium(3)|large_intestine(8)|lung(5)|ovary(1)	18	all_cancers(143;1.19e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.28e-24)|all cancers(36;1.01e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00259)	Choline(DB00122)	GCTTCGGGCTGATGGCCTGCA	0.582000													4	12					0	0	1	0	0
KCNU1	157855	broad.mit.edu	37	8	36788510	36788510	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr8:36788510G>T	ENST00000518904.1	+	2	181	c.112G>T	c.(112-114)Ggt>Tgt	p.G38C	KCNU1_ENST00000399881.3_Silent_p.L926L			A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	784						voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(31)|ovary(1)|urinary_tract(1)	57				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		TTCAGATGCTGGTGACAGGAG	0.453000													14	65					3.27435e-08	3.46887e-08	1	1	0
RALGAPB	57148	broad.mit.edu	37	20	37174949	37174949	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr20:37174949G>A	ENST00000262879.6	+	19	3062	c.2778G>A	c.(2776-2778)gtG>gtA	p.V926V	RALGAPB_ENST00000397038.1_Silent_p.V704V|RALGAPB_ENST00000397040.1_Silent_p.V926V|RALGAPB_ENST00000397042.3_Silent_p.V922V			Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit (non-catalytic)	926					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(29)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						GTAGTCTTGTGAATGAGACCA	0.438000													19	100					0	0	1	0	0
MSL3P1	151507	broad.mit.edu	37	2	234775296	234775296	+	RNA	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:234775296C>G	ENST00000438684.1	-	0	818					NR_024322.1																						AGGACCGCCTCAGAGACTGCA	0.612000													15	17					0	0	1	0	0
CCDC30	728621	broad.mit.edu	37	1	43011226	43011226	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:43011226G>A	ENST00000428554.2	+	11	1544	c.401G>A	c.(400-402)cGa>cAa	p.R134Q	CCDC30_ENST00000342022.4_Missense_Mutation_p.R134Q|CCDC30_ENST00000390640.4_Intron|CCDC30_ENST00000340612.4_Missense_Mutation_p.R134Q|CCDC30_ENST00000507855.1_Intron			Q5VVM6	CCD30_HUMAN	coiled-coil domain containing 30	134										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(2)	30						ATTCAAAGCCGAAAGGAAGAG	0.328000													10	61					0	0	1	0	0
PCDH7	5099	broad.mit.edu	37	4	31144170	31144170	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr4:31144170C>A	ENST00000543491.1	+	3	3467	c.3467C>A	c.(3466-3468)tCc>tAc	p.S1156Y				O60245	PCDH7_HUMAN	protocadherin 7	0					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(8)|liver(1)|lung(26)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	55						CACTCAGACTCCTGCTGGATG	0.522000													27	89					1.17739e-12	1.27684e-12	1	1	0
FPGS	2356	broad.mit.edu	37	9	130573250	130573250	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr9:130573250C>G	ENST00000373225.3	+	14	1373	c.1164C>G	c.(1162-1164)ttC>ttG	p.F388L	FPGS_ENST00000373245.1_3'UTR|FPGS_ENST00000460181.1_3'UTR|FPGS_ENST00000393706.2_Missense_Mutation_p.F412L|FPGS_ENST00000373247.2_Missense_Mutation_p.F438L	NM_001018078.1	NP_001018088.1	Q05932	FOLC_HUMAN	folylpolyglutamate synthase	438					folic acid metabolic process|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|one-carbon metabolic process	cytosol|mitochondrial matrix	ATP binding|tetrahydrofolylpolyglutamate synthase activity			endometrium(2)|kidney(1)|lung(3)|ovary(1)	7					L-Glutamic Acid(DB00142)	ATGCCGTCTTCTGCCCTAACC	0.592000													3	6					0	0	1	0	0
AGBL5	60509	broad.mit.edu	37	2	27275977	27275977	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:27275977G>A	ENST00000360131.4	+	2	310	c.151G>A	c.(151-153)Gac>Aac	p.D51N	AGBL5_ENST00000323064.8_Missense_Mutation_p.D51N	NM_021831.5	NP_068603.4	Q8NDL9	CBPC5_HUMAN	ATP/GTP binding protein-like 5	51					protein branching point deglutamylation|proteolysis	cytosol|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(8)|ovary(3)|pancreas(1)|prostate(2)|skin(1)	28	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTCTTCCCCTGACTATGAATT	0.532000													37	80					0	0	1	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33577065	33577065	+	Silent	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr5:33577065G>T	ENST00000504830.1	-	19	3401	c.3066C>A	c.(3064-3066)gtC>gtA	p.V1022V	ADAMTS12_ENST00000352040.3_Silent_p.V937V	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	1022	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						TAGGTGGAGGGACGGGCTTTA	0.537000										HNSCC(64;0.19)			8	100					0.0381472	0.0384265	1	1	0
ASB16	92591	broad.mit.edu	37	17	42254125	42254125	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr17:42254125G>T	ENST00000293414.1	+	3	673	c.589G>T	c.(589-591)Gaa>Taa	p.E197*	ASB16-AS1_ENST00000591166.1_RNA|ASB16-AS1_ENST00000585457.1_RNA|ASB16-AS1_ENST00000588785.1_RNA	NM_080863.4	NP_543139.4	Q96NS5	ASB16_HUMAN	ankyrin repeat and SOCS box containing 16	197					intracellular signal transduction		protein binding			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(2)|liver(2)|lung(2)|prostate(1)	14		Breast(137;0.00765)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.114)		GTTGCTGCTGGAAGCAGGAGC	0.632000													21	53					3.28513e-13	3.57063e-13	1	1	0
BTN3A3	10384	broad.mit.edu	37	6	26448630	26448630	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:26448630G>A	ENST00000244519.2	+	6	1113	c.870G>A	c.(868-870)atG>atA	p.M290I	BTN3A3_ENST00000339789.4_Missense_Mutation_p.M248I|BTN3A3_ENST00000361232.3_Missense_Mutation_p.M248I	NM_006994.4	NP_008925.1	O00478	BT3A3_HUMAN	butyrophilin, subfamily 3, member A3	290						integral to membrane				cervix(1)|endometrium(3)|large_intestine(4)|liver(1)|lung(15)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	30						AGCGAGAGATGAAAGAAATGG	0.488000													14	20					0	0	1	0	0
OR14K1	343170	broad.mit.edu	37	1	247902395	247902395	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:247902395G>T	ENST00000283225.2	+	1	479	c.479G>T	c.(478-480)gGa>gTa	p.G160V	RP11-634B7.4_ENST00000449298.1_RNA					olfactory receptor, family 14, subfamily K, member 1											NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|lung(18)|ovary(1)|urinary_tract(1)	27						TACACAGCTGGAACATTCTCT	0.502000													54	92					2.29192e-23	2.54863e-23	1	1	0
ADGRG6	57211	broad.mit.edu	37	6	142741106	142741106	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:142741106G>A	ENST00000230173.6	+	22	3660	c.3184G>A	c.(3184-3186)Gaa>Aaa	p.E1062K	GPR126_ENST00000367608.2_Missense_Mutation_p.E1034K|GPR126_ENST00000296932.8_Missense_Mutation_p.E1034K|GPR126_ENST00000367609.3_Missense_Mutation_p.E1062K	NM_020455.5	NP_065188	Q86SQ4	GP126_HUMAN	G protein-coupled receptor 126	1062					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			cervix(1)|endometrium(1)|kidney(3)|large_intestine(12)|lung(10)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36	Breast(32;0.176)			OV - Ovarian serous cystadenocarcinoma(155;9.33e-06)|GBM - Glioblastoma multiforme(68;0.00121)		CCTGAGAGAAGAAGTGTTAAG	0.468000													34	102					0	0	1	0	0
ERCC6-PGBD3	101243544	broad.mit.edu	37	10	50723838	50723838	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr10:50723838C>T	ENST00000515869.1	-	6	2847	c.2727G>A	c.(2725-2727)ctG>ctA	p.L909L	PGBD3_ENST00000508005.2_Silent_p.L441L|PGBD3_ENST00000603152.1_Silent_p.L909L|ERCC6_ENST00000355832.5_Intron|PGBD3_ENST00000374127.3_Silent_p.L441L|ERCC6-PGBD3_ENST00000447839.2_Silent_p.L909L	NM_001277059.1	NP_001263988.1																					TCTTCTTTTTCAGTTTCTGGG	0.433000													26	88					0	0	1	0	0
ROBO2	6092	broad.mit.edu	37	3	77651412	77651412	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:77651412C>T	ENST00000461745.1	+	20	3806	c.2906C>T	c.(2905-2907)tCa>tTa	p.S969L	ROBO2_ENST00000487694.3_Missense_Mutation_p.S985L|ROBO2_ENST00000332191.8_Missense_Mutation_p.S969L	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	969					apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		ACGATGCTCTCAGATGGAGCC	0.468000													6	58					0	0	1	0	0
RILPL2	196383	broad.mit.edu	37	12	123907608	123907608	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:123907608C>T	ENST00000280571.8	-	3	884	c.588G>A	c.(586-588)aaG>aaA	p.K196K		NM_145058.1	NP_659495.1	Q969X0	RIPL2_HUMAN	Rab interacting lysosomal protein-like 2	196						cytosol|plasma membrane	identical protein binding			endometrium(1)|large_intestine(2)|lung(2)|skin(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000546)|Epithelial(86;0.00179)|all cancers(50;0.0168)		TTATGATTGTCTTCTCCTCCT	0.507000													11	50					0	0	1	0	0
PCCB	5096	broad.mit.edu	37	3	136002774	136002774	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:136002774C>T	ENST00000471595.1	+	6	657	c.639C>T	c.(637-639)ttC>ttT	p.F213F	PCCB_ENST00000490504.1_Silent_p.F156F|PCCB_ENST00000468777.1_Silent_p.F244F|PCCB_ENST00000251654.4_Silent_p.F213F|PCCB_ENST00000478469.1_Silent_p.F213F|PCCB_ENST00000462637.1_Silent_p.F190F|PCCB_ENST00000483687.1_Silent_p.F194F|PCCB_ENST00000469217.1_Silent_p.F233F|PCCB_ENST00000482086.1_Silent_p.F97F|PCCB_ENST00000466072.1_Silent_p.F213F|PCCB_ENST00000474833.1_3'UTR			P05166	PCCB_HUMAN	propionyl CoA carboxylase, beta polypeptide	213	Carboxyltransferase.				fatty acid beta-oxidation	mitochondrial matrix	ATP binding|propionyl-CoA carboxylase activity			breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|urinary_tract(1)	25					Biotin(DB00121)|L-Valine(DB00161)	TAACAGACTTCACGTTCATGG	0.493000													8	55					0	0	1	0	0
DOPEY1	23033	broad.mit.edu	37	6	83847184	83847184	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:83847184G>A	ENST00000349129.2	+	21	3683	c.3423G>A	c.(3421-3423)aaG>aaA	p.K1141K	DOPEY1_ENST00000237163.5_Silent_p.K1122K|DOPEY1_ENST00000369739.3_Silent_p.K1132K	NM_015018.3	NP_055833.2	Q5JWR5	DOP1_HUMAN	dopey family member 1	1141					protein transport					breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(16)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	67		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		AAATGCCCAAGGAAAGCTCCC	0.453000													9	16					0	0	1	0	0
SYT14	255928	broad.mit.edu	37	1	210273416	210273416	+	Silent	SNP	A	A	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:210273416A>G	ENST00000537238.1	+	7	1051	c.660A>G	c.(658-660)gaA>gaG	p.E220E	SYT14_ENST00000399639.2_Silent_p.E258E|SYT14_ENST00000367019.1_Silent_p.E258E|SYT14_ENST00000472886.1_Silent_p.E258E|SYT14_ENST00000534859.1_Silent_p.E258E|SYT14_ENST00000367015.1_Silent_p.E220E|SYT14_ENST00000271745.7_3'UTR|SYT14_ENST00000422431.1_Silent_p.E303E	NM_001256006.1|NM_153262.3	NP_001242935.1|NP_694994.2	Q8NB59	SYT14_HUMAN	synaptotagmin XIV	258						integral to membrane				endometrium(4)|large_intestine(11)|lung(17)|ovary(1)|prostate(1)|skin(3)	37				OV - Ovarian serous cystadenocarcinoma(81;0.085)		CTGAGCCAGAAGCTAAATATG	0.383000													31	65					0	0	1	0	0
PLA2G1B	5319	broad.mit.edu	37	12	120760074	120760074	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:120760074G>T	ENST00000308366.4	-	4	404	c.369C>A	c.(367-369)aaC>aaA	p.N123K	PLA2G1B_ENST00000549767.1_Missense_Mutation_p.N94K|PLA2G1B_ENST00000423423.3_3'UTR	NM_000928.2	NP_000919.1	P04054	PA21B_HUMAN	phospholipase A2, group IB (pancreas)	123					actin filament organization|activation of MAPK activity|activation of phospholipase A2 activity|arachidonic acid secretion|cellular response to insulin stimulus|glucose transport|interleukin-8 production|leukotriene biosynthetic process|multicellular organismal lipid catabolic process|neutrophil chemotaxis|neutrophil mediated immunity|phosphatidylcholine metabolic process|positive regulation of calcium ion transport into cytosol|positive regulation of DNA replication|positive regulation of immune response|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein secretion|positive regulation of transcription from RNA polymerase II promoter	extracellular space	bile acid binding|calcium ion binding|calcium-dependent phospholipase A2 activity|cell surface binding|receptor binding			endometrium(1)|large_intestine(1)|lung(3)|skin(2)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AGATGGCAGCGTTGCGGTCGC	0.463000													43	114					6.21074e-16	6.82756e-16	1	1	0
ZNF107	51427	broad.mit.edu	37	7	64167872	64167872	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:64167872C>G	ENST00000395391.1	+	4	2565	c.1190C>G	c.(1189-1191)tCa>tGa	p.S397*	ZNF107_ENST00000344930.3_Nonsense_Mutation_p.S397*|ZNF107_ENST00000423627.1_Nonsense_Mutation_p.S397*			Q9UII5	ZN107_HUMAN	zinc finger protein 107	397					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(18)|ovary(1)|stomach(1)	37		Lung NSC(55;0.00948)|all_lung(88;0.0249)				AACCAACACTCAAACCTAATT	0.333000													8	37					0	0	1	0	0
ZNF544	27300	broad.mit.edu	37	19	58773494	58773494	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:58773494G>C	ENST00000269829.4	+	7	1996	c.1522G>C	c.(1522-1524)Gtt>Ctt	p.V508L	ZNF544_ENST00000600220.1_Missense_Mutation_p.V480L|ZNF544_ENST00000596652.1_Missense_Mutation_p.V508L|ZNF544_ENST00000596825.1_3'UTR|CTD-3138B18.4_ENST00000600029.1_Intron|ZNF544_ENST00000596929.1_Intron|ZNF544_ENST00000600044.1_Missense_Mutation_p.V480L|ZNF544_ENST00000599953.1_Missense_Mutation_p.V366L|CTD-3138B18.5_ENST00000597230.1_RNA|ZNF544_ENST00000595981.1_Intron|ZNF544_ENST00000599227.1_3'UTR|ZNF544_ENST00000415203.2_Missense_Mutation_p.V480L	NM_014480.2	NP_055295.2	Q6NX49	ZN544_HUMAN	zinc finger protein 544	508					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|pancreas(1)|skin(1)|urinary_tract(1)	18		all_cancers(17;4.17e-12)|all_epithelial(17;1.25e-08)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.17)|GBM - Glioblastoma multiforme(193;0.018)		GTATGACCTTGTTGTACATCA	0.438000													38	146					0	0	1	0	0
PPP2R1B	5519	broad.mit.edu	37	11	111637028	111637028	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:111637028C>G	ENST00000527614.1	-	1	123	c.58G>C	c.(58-60)Gat>Cat	p.D20H	PPP2R1B_ENST00000341980.6_Missense_Mutation_p.D20H|PPP2R1B_ENST00000427203.2_5'UTR|PPP2R1B_ENST00000393055.2_Missense_Mutation_p.D20H|PPP2R1B_ENST00000426998.2_Missense_Mutation_p.D20H|PPP2R1B_ENST00000311129.5_Missense_Mutation_p.D20H	NM_001177562.1|NM_002716.4	NP_001171033.1|NP_002707.3	P30154	2AAB_HUMAN	protein phosphatase 2, regulatory subunit A, beta	20							protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|liver(1)|lung(10)|prostate(1)|urinary_tract(2)	22		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|Epithelial(105;2.36e-06)|all cancers(92;3.78e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0761)		TATAGCGAATCATCTCCATCT	0.652000													10	68					0	0	1	0	0
ABCA6	23460	broad.mit.edu	37	17	67114092	67114092	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr17:67114092C>G	ENST00000284425.2	-	11	1616	c.1442G>C	c.(1441-1443)aGa>aCa	p.R481T		NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	481	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					CTTAACATTTCTGATTCTGAA	0.338000													21	41					0	0	1	0	0
DNMT3A	1788	broad.mit.edu	37	2	25470578	25470578	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:25470578T>A	ENST00000264709.3	-	8	1233	c.896A>T	c.(895-897)aAa>aTa	p.K299I	DNMT3A_ENST00000321117.5_Missense_Mutation_p.K299I|DNMT3A_ENST00000402667.1_Missense_Mutation_p.K76I|DNMT3A_ENST00000380746.4_Missense_Mutation_p.K110I	NM_175629.2	NP_783328.1	Q9Y6K1	DNM3A_HUMAN	DNA (cytosine-5-)-methyltransferase 3 alpha	299	Interaction with DNMT1 and DNMT3B.|PWWP.				regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(964)|kidney(3)|large_intestine(10)|lung(29)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	1021	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCCCCGCAGTTTCCCCCACAC	0.642000			"""Mis, F, N, S"""		AML								4	53					0	0	1	0	0
AGL	178	broad.mit.edu	37	1	100330038	100330038	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:100330038C>G	ENST00000294724.4	+	5	1035	c.557C>G	c.(556-558)tCa>tGa	p.S186*	AGL_ENST00000361915.3_Nonsense_Mutation_p.S186*|AGL_ENST00000361522.4_Nonsense_Mutation_p.S169*|AGL_ENST00000370161.2_Nonsense_Mutation_p.S170*|AGL_ENST00000370163.3_Nonsense_Mutation_p.S186*|AGL_ENST00000370165.3_Nonsense_Mutation_p.S186*|AGL_ENST00000361302.3_Nonsense_Mutation_p.S170*	NM_000028.2	NP_000019.2	P35573	GDE_HUMAN	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	186					glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(9)|lung(35)|ovary(1)|prostate(4)|skin(3)|urinary_tract(1)	69		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		CCTGACTTTTCAAGACCTAAT	0.363000													30	86					0	0	1	0	0
CYR61	3491	broad.mit.edu	37	1	86047753	86047753	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:86047753C>T	ENST00000451137.2	+	3	644	c.420C>T	c.(418-420)ctC>ctT	p.L140L	CYR61_ENST00000480413.1_3'UTR	NM_001554.4	NP_001545.2	O00622	CYR61_HUMAN	cysteine-rich, angiogenic inducer, 61	140	VWFC.				cell proliferation|chemotaxis|positive regulation of BMP signaling pathway|positive regulation of cell migration|positive regulation of osteoblast differentiation|positive regulation of osteoblast proliferation|positive regulation of protein kinase activity|positive regulation of protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell growth|regulation of ERK1 and ERK2 cascade|wound healing, spreading of cells	extracellular region	heparin binding|insulin-like growth factor binding			central_nervous_system(1)|endometrium(1)|large_intestine(2)|prostate(1)	5				all cancers(265;0.0216)|Epithelial(280;0.0441)		AACTATCTCTCCCCAACTTGG	0.552000											OREG0013583	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	116					0	0	1	0	0
HECTD4	283450	broad.mit.edu	37	12	112616811	112616811	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:112616811G>C	ENST00000550722.1	-	64	11244	c.10849C>G	c.(10849-10851)Ccc>Gcc	p.P3617A	HECTD4_ENST00000377560.5_Missense_Mutation_p.P3591A|HECTD4_ENST00000430131.2_Missense_Mutation_p.P3341A	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		ACCTTCACGGGGTGCTGCTCC	0.622000													24	12					0	0	1	0	0
RRN3P2	653390	broad.mit.edu	37	16	29088001	29088001	+	RNA	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr16:29088001G>C	ENST00000564580.1	+	0	171																											GTGCATTAGAGAATGATTTTT	0.338000													10	29					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1271640	1271640	+	Silent	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:1271640G>T	ENST00000447027.1	+	31	13597	c.13539G>T	c.(13537-13539)ctG>ctT	p.L4513L	MUC5B_ENST00000529681.1_Silent_p.L4510L			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	4510	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		TTCCAGCACTGAGAAGCACAG	0.627000													27	117					3.90053e-15	4.27814e-15	1	1	0
PRKCI	5584	broad.mit.edu	37	3	169999030	169999030	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:169999030C>G	ENST00000295797.4	+	10	1264	c.959C>G	c.(958-960)tCt>tGt	p.S320C		NM_002740.5	NP_002731.4	P41743	KPCI_HUMAN	protein kinase C, iota	320	Protein kinase.				anti-apoptosis|cellular membrane organization|cellular response to insulin stimulus|establishment or maintenance of epithelial cell apical/basal polarity|intracellular signal transduction|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|protein targeting to membrane|secretion|tight junction assembly|vesicle-mediated transport	cytosol|endosome|nucleus|polarisome	ATP binding|phospholipid binding|protein binding|protein kinase C activity|zinc ion binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(16)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	36	all_cancers(22;6.45e-23)|all_epithelial(15;8.52e-28)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			GGGCTGCATTCTTGCTTTCAG	0.383000													20	62					0	0	1	0	0
PKNOX1	5316	broad.mit.edu	37	21	44441458	44441458	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr21:44441458G>A	ENST00000291547.5	+	8	977	c.766G>A	c.(766-768)Gat>Aat	p.D256N	PKNOX1_ENST00000432907.2_Missense_Mutation_p.D139N	NM_004571.3	NP_004562.2	P55347	PKNX1_HUMAN	PBX/knotted 1 homeobox 1	256							sequence-specific DNA binding			cervix(3)|endometrium(3)|kidney(2)|large_intestine(3)|liver(1)|lung(8)|ovary(1)|prostate(1)	22						GCATCAAGATGATGGTTCATC	0.458000													7	26					0	0	1	0	0
OR6K6	128371	broad.mit.edu	37	1	158725016	158725016	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:158725016C>T	ENST00000368144.2	+	1	507	c.411C>T	c.(409-411)atC>atT	p.I137I		NM_001005184.1	NP_001005184.1	Q8NGW6	OR6K6_HUMAN	olfactory receptor, family 6, subfamily K, member 6	137					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(5)|lung(17)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_hematologic(112;0.0378)					CACTTGGTATCACAGAAAGCT	0.493000													16	56					0	0	1	0	0
SRCIN1	80725	broad.mit.edu	37	17	36734904	36734904	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr17:36734904G>C	ENST00000264659.7	-	2	387	c.163C>G	c.(163-165)Cgg>Ggg	p.R55G	SRCIN1_ENST00000578925.1_Missense_Mutation_p.R55G	NM_025248.2	NP_079524.2	Q9C0H9	SRCN1_HUMAN	SRC kinase signaling inhibitor 1	62					exocytosis|negative regulation of protein tyrosine kinase activity|positive regulation of protein tyrosine kinase activity|regulation of cell migration|regulation of dendritic spine morphogenesis|substrate adhesion-dependent cell spreading	actin cytoskeleton|axon|cell junction|cytoplasm|dendrite|postsynaptic density|postsynaptic membrane	protein kinase binding			endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)	19						GTGTGCCGCCGCTCGGACGTG	0.731000													4	4					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24878016	24878016	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr14:24878016C>T	ENST00000382554.3	+	4	1334	c.1016C>T	c.(1015-1017)tCa>tTa	p.S339L		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	339					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						CCTCCAGTATCAGCCCTGGGT	0.582000													3	9					0	0	1	0	0
TMEM181	57583	broad.mit.edu	37	6	159006376	159006376	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:159006376C>T	ENST00000367090.3	+	5	722	c.711C>T	c.(709-711)gtC>gtT	p.V237V		NM_020823.1	NP_065874.1	Q9P2C4	TM181_HUMAN	transmembrane protein 181	237					pathogenesis	integral to membrane	toxin binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|skin(1)	22		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;8.15e-18)|BRCA - Breast invasive adenocarcinoma(81;1.38e-05)		CTGTTAAAGTCGATGGTGTAG	0.443000													20	53					0	0	1	0	0
EP300	2033	broad.mit.edu	37	22	41568569	41568569	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr22:41568569G>A	ENST00000263253.7	+	28	5738	c.4519G>A	c.(4519-4521)Gat>Aat	p.D1507N	RP1-85F18.6_ENST00000415054.1_RNA	NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	1507					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						TTTCGAGGGTGATTTCTGGCC	0.383000			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				16	48					0	0	1	0	0
LARS2	23395	broad.mit.edu	37	3	45500348	45500348	+	Silent	SNP	A	A	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:45500348A>G	ENST00000415258.1	+	7	861	c.720A>G	c.(718-720)caA>caG	p.Q240Q	LARS2_ENST00000414984.1_Silent_p.Q197Q|LARS2_ENST00000265537.3_Silent_p.Q240Q			Q15031	SYLM_HUMAN	leucyl-tRNA synthetase 2, mitochondrial	240					leucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|leucine-tRNA ligase activity			endometrium(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	18				BRCA - Breast invasive adenocarcinoma(193;0.0122)|KIRC - Kidney renal clear cell carcinoma(197;0.0313)|Kidney(197;0.0372)	L-Leucine(DB00149)	ACCTCAGACAATGGTTTATTA	0.512000													5	67					0	0	1	0	0
NPR3	4883	broad.mit.edu	37	5	32783018	32783018	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr5:32783018G>A	ENST00000265074.8	+	6	1653	c.1310G>A	c.(1309-1311)gGa>gAa	p.G437E	NPR3_ENST00000415685.2_Missense_Mutation_p.G221E|NPR3_ENST00000434067.2_Missense_Mutation_p.G221E|NPR3_ENST00000415167.2_Missense_Mutation_p.G437E	NM_000908.3|NM_001204375.1	NP_000899.1|NP_001191304.1	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)	437					osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	24					Nesiritide(DB04899)	GATTATTTTGGAAAAGAAGGT	0.403000													6	24					0	0	1	0	0
HELZ	9931	broad.mit.edu	37	17	65105757	65105757	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr17:65105757G>C	ENST00000358691.5	-	29	4130	c.3964C>G	c.(3964-3966)Cct>Gct	p.P1322A	HELZ_ENST00000580168.1_Missense_Mutation_p.P1323A	NM_014877.3	NP_055692			helicase with zinc finger											NS(1)|breast(5)|endometrium(9)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					ACAACACTAGGACGTGATTCA	0.403000													26	31					0	0	1	0	0
NMT2	9397	broad.mit.edu	37	10	15183526	15183526	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr10:15183526C>G	ENST00000378165.4	-	2	221	c.141G>C	c.(139-141)aaG>aaC	p.K47N	NMT2_ENST00000378150.1_Missense_Mutation_p.R20T|NMT2_ENST00000535341.1_Missense_Mutation_p.R20T|NMT2_ENST00000540259.1_5'UTR	NM_004808.2	NP_004799.1	O60551	NMT2_HUMAN	N-myristoyltransferase 2	47	Poly-Lys.				N-terminal protein myristoylation|protein lipoylation	Golgi apparatus|plasma membrane	glycylpeptide N-tetradecanoyltransferase activity			breast(3)|endometrium(1)|kidney(4)|large_intestine(3)|lung(6)|ovary(1)|upper_aerodigestive_tract(3)	21						tcttctttttctttttGGCTC	0.398000													4	14					0	0	1	0	0
MPL	4352	broad.mit.edu	37	1	43805739	43805739	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:43805739C>T	ENST00000372470.3	+	5	837	c.795C>T	c.(793-795)ctC>ctT	p.L265L	MPL_ENST00000413998.2_Silent_p.L265L	NM_005373.2	NP_005364.1	P40238	TPOR_HUMAN	myeloproliferative leukemia virus oncogene	265					cell proliferation|platelet activation	integral to plasma membrane	cytokine receptor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(551)|large_intestine(3)|lung(7)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	567	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GGATCTCCCTCGGTGGCTCCT	0.592000			Mis		MPD	MPD	congenital amegakaryocytic thrombocytopenia						3	20					0	0	1	0	0
DDX3X	1654	broad.mit.edu	37	X	41196683	41196683	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:41196683C>T	ENST00000399959.2	+	2	923	c.68C>T	c.(67-69)tCt>tTt	p.S23F	DDX3X_ENST00000441189.2_Missense_Mutation_p.S23F|DDX3X_ENST00000542215.1_Missense_Mutation_p.S67F|DDX3X_ENST00000457138.2_Missense_Mutation_p.S23F|DDX3X_ENST00000478993.1_3'UTR	NM_001193416.1|NM_001193417.1|NM_001356.3	NP_001180345.1|NP_001180346.1|NP_001347.3	O00571	DDX3X_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked	23					interspecies interaction between organisms	cytoplasm|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding|RNA binding			NS(3)|breast(8)|central_nervous_system(36)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	84						GACCTGAACTCTTCAGATAAT	0.413000										HNSCC(61;0.18)			16	76					0	0	1	0	0
CCDC63	160762	broad.mit.edu	37	12	111311690	111311690	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:111311690C>T	ENST00000308208.5	+	5	656	c.414C>T	c.(412-414)ttC>ttT	p.F138F	CCDC63_ENST00000545036.1_Silent_p.F98F|CCDC63_ENST00000552694.1_Silent_p.F59F|CCDC63_ENST00000550317.1_3'UTR	NM_152591.1	NP_689804.1	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	138										NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(1)	39						AACAGATTTTCGCAAAAATGC	0.413000													23	122					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90074321	90074321	+	Silent	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr5:90074321G>C	ENST00000405460.2	+	63	12840	c.12744G>C	c.(12742-12744)ctG>ctC	p.L4248L		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	4248					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GAGGAGTTCTGAGTGAATCCA	0.493000													5	6					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247587973	247587973	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:247587973T>G	ENST00000366497.2	+	4	2008	c.1228T>G	c.(1228-1230)Ttc>Gtc	p.F410V	NLRP3_ENST00000336119.3_Missense_Mutation_p.F410V|NLRP3_ENST00000391827.2_Missense_Mutation_p.F410V|NLRP3_ENST00000348069.2_Missense_Mutation_p.F410V|NLRP3_ENST00000474792.1_3'UTR|NLRP3_ENST00000366496.2_Missense_Mutation_p.F410V|NLRP3_ENST00000391828.3_Missense_Mutation_p.F410V	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	410	NACHT.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			CACCATGTGCTTCATCCCCCT	0.537000													4	33					0	0	1	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33751629	33751629	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr5:33751629C>T	ENST00000504830.1	-	3	849	c.514G>A	c.(514-516)Gga>Aga	p.G172R	ADAMTS12_ENST00000504582.1_5'UTR|ADAMTS12_ENST00000515401.1_Missense_Mutation_p.G172R|ADAMTS12_ENST00000352040.3_Missense_Mutation_p.G172R	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	172					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						AAAAAGTCTCCATGTGGTAGT	0.383000										HNSCC(64;0.19)			30	82					0	0	1	0	0
SLC6A2	6530	broad.mit.edu	37	16	55690822	55690822	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr16:55690822C>T	ENST00000379906.2	+	1	471	c.216C>T	c.(214-216)ttC>ttT	p.F72F	SLC6A2_ENST00000561820.1_Silent_p.F72F|SLC6A2_ENST00000219833.8_Silent_p.F72F|SLC6A2_ENST00000568943.1_Silent_p.F72F|SLC6A2_ENST00000414754.3_Silent_p.F72F|SLC6A2_ENST00000566163.1_Silent_p.F72F	NM_001043.3	NP_001034.1	P23975	SC6A2_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 2	72					synaptic transmission	integral to plasma membrane|membrane fraction	norepinephrine:sodium symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(3)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(1)	41				BRCA - Breast invasive adenocarcinoma(181;0.01)|Kidney(780;0.0267)	Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Atomoxetine(DB00289)|Bethanidine(DB00217)|Bupropion(DB01156)|Clomipramine(DB01242)|Cocaine(DB00907)|Debrisoquin(DB04840)|Desipramine(DB01151)|Diethylpropion(DB00937)|Doxepin(DB01142)|Duloxetine(DB00476)|Ergotamine(DB00696)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Imipramine(DB00458)|Maprotiline(DB00934)|Mazindol(DB00579)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Protriptyline(DB00344)|Reboxetine(DB00234)|Sibutramine(DB01105)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)	TAGTCGGCTTCGCAGTGGACC	0.672000													17	54					0	0	1	0	0
FOXN3	1112	broad.mit.edu	37	14	89878715	89878715	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr14:89878715G>A	ENST00000345097.4	-	2	222	c.106C>T	c.(106-108)Cag>Tag	p.Q36*	FOXN3_ENST00000557258.1_Nonsense_Mutation_p.Q36*|FOXN3_ENST00000261302.5_Nonsense_Mutation_p.Q36*|FOXN3_ENST00000555353.1_Nonsense_Mutation_p.Q36*|RP11-33N16.3_ENST00000555070.1_RNA	NM_001085471.1	NP_001078940.1	O00409	FOXN3_HUMAN	forkhead box N3	36					DNA damage checkpoint|embryo development|G2 phase of mitotic cell cycle|negative regulation of transcription, DNA-dependent|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein C-terminus binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(4)|large_intestine(4)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						TCGTCTTCCTGAAGGGCCTTG	0.537000													17	35					0	0	1	0	0
BAZ2A	11176	broad.mit.edu	37	12	56994860	56994860	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:56994860C>T	ENST00000179765.5	-	23	4426	c.4227G>A	c.(4225-4227)tgG>tgA	p.W1409*	BAZ2A_ENST00000553222.1_5'UTR|BAZ2A_ENST00000549884.1_Nonsense_Mutation_p.W1439*|BAZ2A_ENST00000551812.1_Nonsense_Mutation_p.W1441*|BAZ2A_ENST00000379441.3_Nonsense_Mutation_p.W1411*			Q9UIF9	BAZ2A_HUMAN	bromodomain adjacent to zinc finger domain, 2A	1441	Pro-rich.				chromatin silencing at rDNA|DNA methylation|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	DNA binding|histone acetyl-lysine binding|ligand-dependent nuclear receptor binding|RNA binding|zinc ion binding			breast(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(15)|urinary_tract(1)	31						GATCTCGTATCCACCACCAGC	0.557000													5	12					0	0	1	0	0
CILP	8483	broad.mit.edu	37	15	65491157	65491157	+	Silent	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr15:65491157C>A	ENST00000261883.4	-	9	1633	c.1467G>T	c.(1465-1467)cgG>cgT	p.R489R		NM_003613.3	NP_003604	O75339	CILP1_HUMAN	cartilage intermediate layer protein, nucleotide pyrophosphohydrolase	489					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				breast(5)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(17)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	55						GCACGATGCTCCGAGTTTCCG	0.592000													11	36					1.5842e-08	1.68201e-08	1	1	0
CTTNBP2	83992	broad.mit.edu	37	7	117420596	117420596	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:117420596C>G	ENST00000160373.3	-	7	2513	c.2422G>C	c.(2422-2424)Gat>Cat	p.D808H		NM_033427.2	NP_219499.1	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	808										breast(3)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(36)|ovary(4)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		TGTCCTCCATCAGCAGCATGA	0.348000													8	44					0	0	1	0	0
NEUROD1	4760	broad.mit.edu	37	2	182543225	182543225	+	Silent	SNP	T	T	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:182543225T>C	ENST00000295108.3	-	2	820	c.363A>G	c.(361-363)ctA>ctG	p.L121L	CERKL_ENST00000479558.1_Intron|NEUROD1_ENST00000496876.1_Intron	NM_002500.4	NP_002491.2	Q13562	NDF1_HUMAN	neuronal differentiation 1	121	Helix-loop-helix motif.				amacrine cell differentiation|cerebellum development|dentate gyrus development|embryonic organ morphogenesis|enteroendocrine cell differentiation|glucose homeostasis|inner ear development|insulin secretion|negative regulation of apoptosis|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of intestinal epithelial structure maintenance|response to glucose stimulus	cytoplasm|nucleus	chromatin binding|E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25			OV - Ovarian serous cystadenocarcinoma(117;0.088)			GCAGGTTGTCTAGCGCCGCGT	0.552000													31	45					0	0	1	0	0
LRRC32	2615	broad.mit.edu	37	11	76371368	76371368	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:76371368G>A	ENST00000407242.2	-	3	1511	c.1269C>T	c.(1267-1269)agC>agT	p.S423S	LRRC32_ENST00000260061.5_Silent_p.S423S|LRRC32_ENST00000404995.1_Silent_p.S423S|LRRC32_ENST00000464145.1_Intron|AP001189.4_ENST00000447519.1_RNA	NM_005512.2	NP_005503.1	Q14392	LRC32_HUMAN	leucine rich repeat containing 32	423						integral to plasma membrane				endometrium(1)|large_intestine(3)|lung(26)|upper_aerodigestive_tract(1)	31						CCCCACAGGGGCTGACTCGGT	0.657000													4	7					0	0	1	0	0
TICAM1	148022	broad.mit.edu	37	19	4817058	4817058	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:4817058G>A	ENST00000248244.5	-	2	1561	c.1332C>T	c.(1330-1332)gaC>gaT	p.D444D		NM_182919.3	NP_891549.1	Q8IUC6	TCAM1_HUMAN	toll-like receptor adaptor molecule 1	444	TIR.				apoptosis|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein kinase binding|signal transducer activity			NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	26				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		GGTCTATGGCGTCCTGCAGGC	0.622000													7	33					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179588344	179588344	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:179588344T>A	ENST00000589042.1	-	74	21707	c.21483A>T	c.(21481-21483)agA>agT	p.R7161S	TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.R5917S|TTN_ENST00000342175.6_Intron|RP11-171I2.1_ENST00000590024.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.R6844S	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6844	Ig-like 53.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAGGGGTTCCTCTAATAACGC	0.438000													5	22					0	0	1	0	0
UROC1	131669	broad.mit.edu	37	3	126218960	126218960	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:126218960C>G	ENST00000290868.2	-	12	1236	c.1183G>C	c.(1183-1185)Gag>Cag	p.E395Q	UROC1_ENST00000383579.3_Missense_Mutation_p.E455Q	NM_144639.2	NP_653240.1	Q96N76	HUTU_HUMAN	urocanate hydratase 1	395					histidine catabolic process	cytosol	urocanate hydratase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(1)|skin(1)	39				GBM - Glioblastoma multiforme(114;0.17)		AACTTCTCCTCGGCCAACCTG	0.622000													8	33					0	0	1	0	0
EPHA8	2046	broad.mit.edu	37	1	22915528	22915528	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:22915528G>A	ENST00000166244.3	+	5	1216	c.1144G>A	c.(1144-1146)Ggc>Agc	p.G382S	EPHA8_ENST00000538803.1_Missense_Mutation_p.G382S|EPHA8_ENST00000374644.4_Missense_Mutation_p.G382S	NM_020526.3	NP_065387.1	P29322	EPHA8_HUMAN	EPH receptor A8	382	Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity	p.G382S(2)		breast(3)|central_nervous_system(5)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(6)|lung(22)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		ATGTGGGAGCGGCACCCGCTT	0.677000													11	19					0	0	1	0	0
NTSR2	23620	broad.mit.edu	37	2	11798693	11798693	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:11798693G>T	ENST00000306928.5	-	4	1179	c.1145C>A	c.(1144-1146)cCc>cAc	p.P382H		NM_012344.3	NP_036476	O95665	NTR2_HUMAN	neurotensin receptor 2	382					sensory perception	integral to plasma membrane		p.P382H(1)		breast(1)|large_intestine(7)|lung(7)|prostate(1)|urinary_tract(1)	17	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.129)|OV - Ovarian serous cystadenocarcinoma(76;0.24)	Levocabastine(DB01106)	CCGCTTCATGGGGTGGTGCTC	0.567000													13	81					1.49906e-05	1.56402e-05	1	1	0
POLN	353497	broad.mit.edu	37	4	2200254	2200254	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr4:2200254G>A	ENST00000511885.2	-	6	1258	c.905C>T	c.(904-906)gCc>gTc	p.A302V	POLN_ENST00000515357.1_5'UTR|POLN_ENST00000382865.1_Missense_Mutation_p.A302V			Q7Z5Q5	DPOLN_HUMAN	polymerase (DNA directed) nu	302					DNA repair|DNA replication	nucleus	DNA binding|DNA-directed DNA polymerase activity			kidney(6)|large_intestine(5)|liver(1)|lung(8)|ovary(2)|skin(4)|urinary_tract(2)	28			OV - Ovarian serous cystadenocarcinoma(23;0.0955)			TTCTTACCGGGCAAATTGTTG	0.428000								DNA polymerases (catalytic subunits)					4	177					0	0	1	0	0
LINGO3	645191	broad.mit.edu	37	19	2290237	2290237	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:2290237C>G	ENST00000585527.1	-	1	1786	c.1539G>C	c.(1537-1539)gaG>gaC	p.E513D	LINGO3_ENST00000404279.1_Missense_Mutation_p.E513D			P0C6S8	LIGO3_HUMAN	leucine rich repeat and Ig domain containing 3	513						integral to membrane				lung(1)|urinary_tract(1)	2						CCGCCAGCGTCTCGTTGTGGG	0.721000													7	27					0	0	1	0	0
PRR5-ARHGAP8	553158	broad.mit.edu	37	22	45241152	45241152	+	Silent	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr22:45241152C>G	ENST00000352766.7	+	13	1230	c.1230C>G	c.(1228-1230)ctC>ctG	p.L410L	ARHGAP8_ENST00000389773.5_Silent_p.L322L|ARHGAP8_ENST00000356099.6_Silent_p.L200L|ARHGAP8_ENST00000389774.2_Silent_p.L231L|ARHGAP8_ENST00000336963.4_Silent_p.L200L|PRR5-ARHGAP8_ENST00000361473.5_Silent_p.L331L|ARHGAP8_ENST00000517296.3_Silent_p.L410L																breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(10)|prostate(1)|skin(8)	30						TTCTCAGCCTCAAAGACAAAA	0.517000													22	16					0	0	1	0	0
MUC1	4582	broad.mit.edu	37	1	155160209	155160209	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:155160209G>C	ENST00000368395.1	-	5	1141	c.1070C>G	c.(1069-1071)tCa>tGa	p.S357*	MUC1_ENST00000343256.5_Intron|MUC1_ENST00000368396.4_Intron|MUC1_ENST00000342482.4_Intron|MUC1_ENST00000438413.1_Nonsense_Mutation_p.S111*|MUC1_ENST00000368393.3_Nonsense_Mutation_p.S155*|MUC1_ENST00000368392.3_Nonsense_Mutation_p.S146*|MUC1_ENST00000457295.2_Nonsense_Mutation_p.S146*|MUC1_ENST00000368389.2_Intron|MUC1_ENST00000338684.5_Nonsense_Mutation_p.S106*|MUC1_ENST00000368398.3_Nonsense_Mutation_p.S112*|MUC1_ENST00000368390.3_Nonsense_Mutation_p.S137*|MUC1_ENST00000337604.5_Nonsense_Mutation_p.S155*|MUC1_ENST00000462215.1_5'UTR	NM_001204285.1|NM_001204286.1	NP_001191214.1|NP_001191215.1	P15941	MUC1_HUMAN	mucin 1, cell surface associated	1137	42 X 20 AA approximate tandem repeats of P-A-P-G-S-T-A-P-P-A-H-G-V-T-S-A-P-D-T-R.					apical plasma membrane|cell surface|cytoplasm|extracellular region|integral to plasma membrane|nucleus	protein binding			breast(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|pancreas(1)|skin(2)	10	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;5.31e-10)|all cancers(21;2.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			GCTGACGTCTGAGATCGTCAG	0.567000			T	IGH@	B-NHL								18	50					0	0	1	0	0
TECR	9524	broad.mit.edu	37	19	14640521	14640521	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:14640521G>A	ENST00000215567.5	+	1	150	c.13G>A	c.(13-15)Gag>Aag	p.E5K	TECR_ENST00000596073.1_5'UTR|TECR_ENST00000596164.1_3'UTR|TECR_ENST00000600083.1_5'UTR|TECR_ENST00000436007.2_5'UTR	NM_138501.5	NP_612510.1	Q9NZ01	TECR_HUMAN	trans-2,3-enoyl-CoA reductase	5					fatty acid elongation|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	integral to endoplasmic reticulum membrane	trans-2-enoyl-CoA reductase (NADPH) activity|very long-chain-acyl-CoA dehydrogenase activity			endometrium(1)|large_intestine(1)|ovary(1)	3						GAAGCATTACGAGGTAAGAAG	0.632000													4	30					0	0	1	0	0
ADCY9	115	broad.mit.edu	37	16	4042323	4042323	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr16:4042323G>A	ENST00000294016.3	-	5	2569	c.2031C>T	c.(2029-2031)ctC>ctT	p.L677L	ADCY9_ENST00000571889.1_Intron	NM_001116.3	NP_001107.2	O60503	ADCY9_HUMAN	adenylate cyclase 9	677					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						GGGGAGGGCTGAGGAGCCCGT	0.592000													14	20					0	0	1	0	0
TLR8	51311	broad.mit.edu	37	X	12938526	12938526	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:12938526C>G	ENST00000218032.6	+	2	1454	c.1367C>G	c.(1366-1368)tCa>tGa	p.S456*	TLR8_ENST00000311912.5_Nonsense_Mutation_p.S474*	NM_138636.4	NP_619542.1	Q9NR97	TLR8_HUMAN	toll-like receptor 8	456					cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						AAACGACGCTCAACAGATTTT	0.388000													53	92					0	0	1	0	0
MED13L	23389	broad.mit.edu	37	12	116450678	116450678	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:116450678C>G	ENST00000281928.3	-	9	1410	c.1204G>C	c.(1204-1206)Gaa>Caa	p.E402Q		NM_015335.4	NP_056150.1	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	402					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					NS(2)|breast(1)|endometrium(9)|kidney(3)|large_intestine(18)|lung(34)|ovary(4)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	85	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		GGCTCTTCTTCAAGAGTTGGA	0.413000													22	73					0	0	1	0	0
COL4A5	1287	broad.mit.edu	37	X	107939599	107939599	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:107939599G>A	ENST00000328300.6	+	53	5311	c.5067G>A	c.(5065-5067)aaG>aaA	p.K1689K	COL4A5_ENST00000361603.2_Silent_p.K1683K	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5	1683					axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						TGTGCATGAAGAGGACATAAC	0.358000									Alport syndrome with Diffuse Leiomyomatosis				18	51					0	0	1	0	0
BOD1L1	259282	broad.mit.edu	37	4	13606519	13606519	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr4:13606519C>T	ENST00000040738.5	-	10	2140	c.2005G>A	c.(2005-2007)Gaa>Aaa	p.E669K		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	669	Lys-rich.						DNA binding										TCAGTCTCTTCCTGTACCCCC	0.403000													42	230					0	0	1	0	0
AKAP9	10142	broad.mit.edu	37	7	91660846	91660846	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:91660846G>A	ENST00000359028.2	+	17	4527	c.4302G>A	c.(4300-4302)gtG>gtA	p.V1434V	AKAP9_ENST00000356239.3_Silent_p.V1422V|AKAP9_ENST00000358100.2_Silent_p.V1434V			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	1434					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AATTTGGAGTGAAAGAGGAAA	0.294000			T	BRAF	papillary thyroid								10	58					0	0	1	0	0
SCAND3	114821	broad.mit.edu	37	6	28543861	28543861	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:28543861G>A	ENST00000452236.2	-	3	1238	c.621C>T	c.(619-621)ctC>ctT	p.L207L	SCAND3_ENST00000530247.1_5'UTR	NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	207					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						CTAAGCTACTGAGGTTATCAC	0.318000													20	21					0	0	1	0	0
L1TD1	54596	broad.mit.edu	37	1	62677014	62677014	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:62677014G>C	ENST00000498273.1	+	4	2863	c.2568G>C	c.(2566-2568)ttG>ttC	p.L856F		NM_001164835.1|NM_019079.4	NP_001158307.1|NP_061952.3	Q5T7N2	LITD1_HUMAN	LINE-1 type transposase domain containing 1	856										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	35						tgcccaccttgagagaattac	0.378000													26	43					0	0	1	0	0
WWC3	55841	broad.mit.edu	37	X	10058934	10058934	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:10058934G>A	ENST00000380861.4	+	6	892	c.501G>A	c.(499-501)ctG>ctA	p.L167L	WWC3_ENST00000454666.1_Silent_p.L167L	NM_015691.3	NP_056506.2	Q9ULE0	WWC3_HUMAN	WWC family member 3	167										NS(1)|breast(3)|endometrium(10)|kidney(1)|large_intestine(11)|lung(17)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	52						GGCGGGACCTGATGCATGTAA	0.413000													14	40					0	0	1	0	0
LMTK2	22853	broad.mit.edu	37	7	97784176	97784176	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:97784176G>A	ENST00000297293.5	+	5	850	c.557G>A	c.(556-558)gGa>gAa	p.G186E		NM_014916.3	NP_055731.2	Q8IWU2	LMTK2_HUMAN	lemur tyrosine kinase 2	186	Protein kinase.				early endosome to late endosome transport|endocytic recycling|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation|receptor recycling|transferrin transport	early endosome|Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|recycling endosome	ATP binding|myosin VI binding|protein phosphatase inhibitor activity|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(25)|ovary(1)|pancreas(2)|skin(2)|stomach(3)	59	all_cancers(62;3.23e-09)|all_epithelial(64;7.65e-10)|Lung NSC(181;0.00902)|all_lung(186;0.0104)|Esophageal squamous(72;0.0125)					TTGAAAAATGGAGAACCTTAC	0.418000													5	69					0	0	1	0	0
SPAG16	79582	broad.mit.edu	37	2	215275015	215275015	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:215275015C>T	ENST00000331683.5	+	16	1967	c.1872C>T	c.(1870-1872)gaC>gaT	p.D624D	SPAG16_ENST00000374309.3_Silent_p.D530D|AC107218.3_ENST00000437883.1_RNA|AC107218.3_ENST00000412896.1_RNA	NM_024532.4	NP_078808.3	Q8N0X2	SPG16_HUMAN	sperm associated antigen 16	624					cilium assembly	cilium axoneme|flagellar axoneme				endometrium(4)|kidney(1)|large_intestine(15)|lung(27)|ovary(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	56		Renal(323;0.00461)		UCEC - Uterine corpus endometrioid carcinoma (47;0.0525)|Epithelial(149;7.07e-07)|all cancers(144;7.96e-05)|Lung(261;0.00255)|LUSC - Lung squamous cell carcinoma(224;0.00599)		GAGGCTCTGACGGCACAGTTC	0.512000													10	51					0	0	1	0	0
RNF217-AS1	7955	broad.mit.edu	37	6	125231651	125231651	+	RNA	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:125231651G>C	ENST00000439075.1	-	0	3094					NR_026876.1																						AGTACAATTAGATCAAACATA	0.249000													4	16					0	0	1	0	0
SMG1	23049	broad.mit.edu	37	16	18877945	18877945	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr16:18877945C>T	ENST00000446231.2	-	23	3760	c.3348G>A	c.(3346-3348)ggG>ggA	p.G1116G	SMG1_ENST00000389467.3_Silent_p.G1116G			Q96Q15	SMG1_HUMAN	SMG1 phosphatidylinositol 3-kinase-related kinase	1116	Interaction with SMG8 and SMG9.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(8)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(37)|ovary(1)|skin(1)|stomach(4)|urinary_tract(1)	92						CAACCTACCTCCCTTCAGCCT	0.393000													23	44					0	0	1	0	0
SBNO2	22904	broad.mit.edu	37	19	1112019	1112019	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:1112019G>A	ENST00000361757.3	-	23	2913	c.2676C>T	c.(2674-2676)ctC>ctT	p.L892L	SBNO2_ENST00000587024.1_Silent_p.L882L|SBNO2_ENST00000438103.2_Silent_p.L835L	NM_014963.2	NP_055778.2	Q9Y2G9	SBNO2_HUMAN	strawberry notch homolog 2 (Drosophila)	892					macrophage activation involved in immune response|negative regulation of transcription, DNA-dependent|regulation of inflammatory response|transcription, DNA-dependent					NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	14		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGTACTTGCTGAGGTCACGGG	0.672000													7	55					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179640102	179640102	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:179640102G>T	ENST00000589042.1	-	28	6713	c.6489C>A	c.(6487-6489)caC>caA	p.H2163Q	TTN_ENST00000342992.6_Missense_Mutation_p.H2163Q|TTN_ENST00000342175.6_Missense_Mutation_p.H2117Q|TTN_ENST00000359218.5_Missense_Mutation_p.H2117Q|TTN_ENST00000360870.5_Missense_Mutation_p.H2163Q|TTN_ENST00000460472.2_Missense_Mutation_p.H2117Q|TTN_ENST00000591111.1_Missense_Mutation_p.H2163Q	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1924	Ig-like 10.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTAAGAATGCGTGACTGGAGG	0.393000													8	58					5.4927e-09	5.85119e-09	1	1	0
USP47	55031	broad.mit.edu	37	11	11957937	11957937	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:11957937G>A	ENST00000339865.5	+	16	2516	c.1753G>A	c.(1753-1755)Gaa>Aaa	p.E585K	USP47_ENST00000539466.1_5'UTR|USP47_ENST00000399455.2_Missense_Mutation_p.E673K|USP47_ENST00000527733.1_Missense_Mutation_p.E653K	NM_017944.3	NP_060414.3	Q96K76	UBP47_HUMAN	ubiquitin specific peptidase 47	673					base-excision repair|cellular response to UV|monoubiquitinated protein deubiquitination|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of cell growth|response to drug|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|WD40-repeat domain binding			breast(4)|endometrium(7)|kidney(2)|large_intestine(8)|liver(2)|lung(14)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	46				Epithelial(150;0.000339)		ACGGTCATATGAAGGAGAAGA	0.398000													12	43					0	0	1	0	0
SLC2A8	29988	broad.mit.edu	37	9	130167755	130167755	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr9:130167755C>T	ENST00000373371.3	+	9	1296	c.1207C>T	c.(1207-1209)Ctg>Ttg	p.L403L	SLC2A8_ENST00000373360.3_Intron|SLC2A8_ENST00000373352.1_Silent_p.L140L	NM_001271712.1|NM_014580.3	NP_001258641.1|NP_055395.2	Q9NY64	GTR8_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 8	403						cytoplasmic vesicle membrane|integral to plasma membrane	D-glucose transmembrane transporter activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(2)|ovary(1)	11						GATCTTCCCTCTGCATGTCAA	0.627000													14	32					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215813826	215813826	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:215813826G>C	ENST00000272895.7	-	46	7119	c.6900C>G	c.(6898-6900)ttC>ttG	p.F2300L	ABCA12_ENST00000389661.4_Missense_Mutation_p.F1982L|AC072062.1_ENST00000607412.1_RNA	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	2300	ABC transporter 2.				cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TCAGCATCTTGAATATAGTGG	0.393000													21	69					0	0	1	0	0
RNF20	56254	broad.mit.edu	37	9	104303103	104303103	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr9:104303103C>T	ENST00000389120.3	+	5	564	c.474C>T	c.(472-474)ttC>ttT	p.F158F		NM_019592.5	NP_062538.5	Q5VTR2	BRE1A_HUMAN	ring finger protein 20, E3 ubiquitin protein ligase	158					histone H2B ubiquitination|histone monoubiquitination|negative regulation of cell migration|positive regulation of transcription, DNA-dependent|protein polyubiquitination|ubiquitin-dependent protein catabolic process	nucleolus|ubiquitin ligase complex	histone binding|p53 binding|transcription coactivator activity|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(3)|kidney(6)|large_intestine(7)|lung(23)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_hematologic(171;8.99e-06)|Acute lymphoblastic leukemia(62;0.000365)|Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.88e-19)|STAD - Stomach adenocarcinoma(157;0.00311)		CTTTCTCTTTCCTTGCTACTT	0.483000													20	34					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113275983	113275983	+	Silent	SNP	G	G	A	rs61754530		TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr8:113275983G>A	ENST00000297405.5	-	61	9991	c.9747C>T	c.(9745-9747)ttC>ttT	p.F3249F	CSMD3_ENST00000343508.3_Silent_p.F3209F|CSMD3_ENST00000455883.2_Silent_p.F3080F|CSMD3_ENST00000352409.3_Silent_p.F3179F	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	3249	Sushi 25.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						AGCCCCAGTCGAAATTTGTTC	0.453000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			15	52					0	0	1	0	0
TM4SF4	7104	broad.mit.edu	37	3	149220466	149220466	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:149220466G>C	ENST00000305354.4	+	5	1499	c.595G>C	c.(595-597)Gat>Cat	p.D199H		NM_004617.3	NP_004608.1	P48230	T4S4_HUMAN	transmembrane 4 L six family member 4	199						integral to membrane				large_intestine(3)|lung(4)|ovary(1)|prostate(1)	9			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			CTTCTAGGGAGATGGACCCGT	0.403000													22	84					0	0	1	0	0
BNIPL	149428	broad.mit.edu	37	1	151018334	151018334	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:151018334C>G	ENST00000295294.7	+	8	1276	c.667C>G	c.(667-669)Ctg>Gtg	p.L223V	BNIPL_ENST00000491386.1_3'UTR|BNIPL_ENST00000368931.3_Missense_Mutation_p.L305V	NM_001159642.1	NP_001153114.1	Q7Z465	BNIPL_HUMAN	BCL2/adenovirus E1B 19kD interacting protein like	305	CRAL-TRIO.				apoptosis|induction of apoptosis|negative regulation of cell proliferation|regulation of growth rate	cytosol|nucleus	identical protein binding			autonomic_ganglia(1)|endometrium(3)|large_intestine(1)|lung(4)|skin(1)	10	Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GAAAGCATTTCTGGCACTGCT	0.453000													61	74					0	0	1	0	0
PJA2	9867	broad.mit.edu	37	5	108691666	108691666	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr5:108691666G>C	ENST00000361189.2	-	7	1953	c.1714C>G	c.(1714-1716)Cag>Gag	p.Q572E	PJA2_ENST00000361557.3_Missense_Mutation_p.Q572E	NM_014819.4	NP_055634.3	O43164	PJA2_HUMAN	praja ring finger 2, E3 ubiquitin protein ligase	572	Interaction with PRKAR1A, PRKAR2A and PRKAR2B.				long-term memory|regulation of protein kinase A signaling cascade	cell junction|endoplasmic reticulum membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	ligase activity|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	21		all_cancers(142;4.4e-06)|all_epithelial(76;8.17e-08)|Prostate(80;0.00676)|Lung NSC(167;0.0436)|Ovarian(225;0.0443)|all_lung(232;0.053)|Colorectal(57;0.0946)|Breast(839;0.151)		OV - Ovarian serous cystadenocarcinoma(64;3.46e-10)|Epithelial(69;6.02e-09)|COAD - Colon adenocarcinoma(37;0.224)		GTAAGGAACTGAGGATCCACA	0.383000													26	49					0	0	1	0	0
HGS	9146	broad.mit.edu	37	17	79657710	79657710	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr17:79657710G>A	ENST00000329138.4	+	7	610	c.475G>A	c.(475-477)Gac>Aac	p.D159N		NM_004712.4	NP_004703.1	O14964	HGS_HUMAN	hepatocyte growth factor-regulated tyrosine kinase substrate	159					cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of JAK-STAT cascade|regulation of protein catabolic process	cytosol|early endosome membrane|multivesicular body membrane	metal ion binding|protein domain specific binding			endometrium(2)|kidney(3)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	12	all_neural(118;0.0878)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)			TCAGGCCCCAGACTGGGTGGA	0.682000													8	41					0	0	1	0	0
TRIM33	51592	broad.mit.edu	37	1	114967341	114967341	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:114967341C>G	ENST00000358465.2	-	10	1815	c.1732G>C	c.(1732-1734)Ggc>Cgc	p.G578R	TRIM33_ENST00000450349.2_Missense_Mutation_p.G186R|TRIM33_ENST00000369543.2_Missense_Mutation_p.G578R	NM_015906.3	NP_056990.3	Q9UPN9	TRI33_HUMAN	tripartite motif containing 33	578					negative regulation of BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	nucleus	co-SMAD binding|DNA binding|ligase activity|R-SMAD binding|zinc ion binding			breast(2)|central_nervous_system(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	48	all_epithelial(7;0.000132)|all_lung(7;0.00106)|Lung SC(450;0.184)	all_cancers(81;3.03e-08)|all_epithelial(167;3.24e-08)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTCATGTTGCCTCTTTGCATT	0.388000			T	RET	papillary thyroid								27	31					0	0	1	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95514981	95514981	+	RNA	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:95514981C>G	ENST00000432432.2	-	0	676					NR_040113.1																						TACTTGCTTTCTTTTTCAATA	0.323000													12	232					0	0	1	0	0
ARMC3	219681	broad.mit.edu	37	10	23287284	23287284	+	Silent	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr10:23287284C>G	ENST00000298032.5	+	11	1467	c.1383C>G	c.(1381-1383)ctC>ctG	p.L461L	ARMC3_ENST00000409983.3_Silent_p.L461L|ARMC3_ENST00000409049.3_Silent_p.L461L|ARMC3_ENST00000376528.4_Silent_p.L198L	NM_173081.3	NP_775104.2	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	461							binding			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(24)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						AAGCTGCTCTCGCTGTCACCG	0.502000													7	20					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215823163	215823163	+	Missense_Mutation	SNP	G	G	C	rs138503581		TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:215823163G>C	ENST00000272895.7	-	41	6174	c.5955C>G	c.(5953-5955)atC>atG	p.I1985M	ABCA12_ENST00000389661.4_Missense_Mutation_p.I1667M|AC072062.1_ENST00000607412.1_RNA	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	1985					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		CTAAAATATCGATTAAACTGC	0.393000													8	34					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124392387	124392387	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr10:124392387C>T	ENST00000338354.3	+	48	6097	c.5991C>T	c.(5989-5991)ctC>ctT	p.L1997L	DMBT1_ENST00000368909.3_Silent_p.L1997L|DMBT1_ENST00000359586.6_Silent_p.L717L|DMBT1_ENST00000368955.3_Silent_p.L1987L|DMBT1_ENST00000344338.3_Silent_p.L1987L|DMBT1_ENST00000330163.4_Silent_p.L1369L|DMBT1_ENST00000368956.2_Silent_p.L1369L			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	1997					epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CTCCTTTTCTCAACATCACCC	0.498000													4	8					0	0	1	0	0
ARHGAP31	57514	broad.mit.edu	37	3	119135096	119135096	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:119135096G>A	ENST00000264245.4	+	12	4852	c.4320G>A	c.(4318-4320)ggG>ggA	p.G1440G		NM_020754.2	NP_065805.2	Q2M1Z3	RHG31_HUMAN	Rho GTPase activating protein 31	1440					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(3)|large_intestine(11)|lung(29)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	67						GAAGAAGTGGGAGGCAAATAG	0.458000													6	39					0	0	1	0	0
OR4C46	119749	broad.mit.edu	37	11	51515674	51515674	+	Missense_Mutation	SNP	G	G	C	rs143619747		TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:51515674G>C	ENST00000328188.1	+	1	393	c.393G>C	c.(391-393)atG>atC	p.M131I		NM_001004703.1	NP_001004703.1	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C, member 46	131					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(5)|large_intestine(5)|lung(31)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	48						TGCACTATATGACTATCATGA	0.478000													43	67					0	0	1	0	0
TAF7	6879	broad.mit.edu	37	5	140698943	140698943	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr5:140698943G>C	ENST00000313368.5	-	1	1387	c.669C>G	c.(667-669)ttC>ttG	p.F223L		NM_005642.2	NP_005633.2	Q15545	TAF7_HUMAN	TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa	223					negative regulation of histone acetylation|negative regulation of protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|spermine transport|transcription initiation from RNA polymerase II promoter	Golgi apparatus|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	histone acetyltransferase binding|thyroid hormone receptor binding|transcription coactivator activity|transcription regulatory region DNA binding|vitamin D receptor binding			central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(5)|skin(1)	12			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAGGTCATTGAATATCTCCC	0.473000													40	46					0	0	1	0	0
GRIK3	2899	broad.mit.edu	37	1	37337945	37337945	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:37337945G>A	ENST00000373091.3	-	4	592	c.576C>T	c.(574-576)atC>atT	p.I192I	GRIK3_ENST00000373093.4_Silent_p.I192I	NM_000831.3	NP_000822.2	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	192					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(27)|lung(35)|ovary(5)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	89		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	ATGGGGCCATGATGAGCTCCT	0.577000													10	53					0	0	1	0	0
ZKSCAN4	387032	broad.mit.edu	37	6	28214835	28214835	+	Silent	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:28214835G>C	ENST00000377294.2	-	4	933	c.690C>G	c.(688-690)ctC>ctG	p.L230L	ZKSCAN4_ENST00000423974.2_Silent_p.L75L	NM_019110.3	NP_061983.2	Q969J2	ZKSC4_HUMAN	zinc finger with KRAB and SCAN domains 4	230	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|large_intestine(2)|lung(10)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	18						ACCCAGGAGTGAGGGTCAGGG	0.478000													28	33					0	0	1	0	0
CCNT1	904	broad.mit.edu	37	12	49093573	49093573	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:49093573G>A	ENST00000261900.3	-	5	706	c.484C>T	c.(484-486)Caa>Taa	p.Q162*		NM_001240.3	NP_001231.2	O60563	CCNT1_HUMAN	cyclin T1	162					cell cycle|cell division|interspecies interaction between organisms|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	DNA binding|protein kinase binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|skin(2)	27						CGAACAAGTTGAGTGCACTTT	0.343000													31	133					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37029032	37029032	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:37029032G>A	ENST00000358047.3	+	1	2601	c.2549G>A	c.(2548-2550)aGa>aAa	p.R850K		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	850										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						CACACATCGAGAAAACTCCGT	0.463000													28	71					0	0	1	0	0
NAA16	79612	broad.mit.edu	37	13	41897194	41897194	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr13:41897194G>C	ENST00000379406.3	+	5	729	c.405G>C	c.(403-405)gaG>gaC	p.E135D	NAA16_ENST00000403412.3_Missense_Mutation_p.E135D|NAA16_ENST00000379367.3_Missense_Mutation_p.E135D	NM_024561.4	NP_078837.3	Q6N069	NAA16_HUMAN	N(alpha)-acetyltransferase 16, NatA auxiliary subunit	135					N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent	cytoplasm|transcription factor complex	binding			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|urinary_tract(2)	31						TTTTTTAGGAGACAAGATACC	0.343000													6	96					0	0	1	0	0
P2RY12	64805	broad.mit.edu	37	3	151056546	151056546	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:151056546G>C	ENST00000302632.3	-	3	387	c.88C>G	c.(88-90)Ctg>Gtg	p.L30V	MED12L_ENST00000491549.1_Intron|MED12L_ENST00000474524.1_Intron|MED12L_ENST00000273432.4_Intron	NM_022788.4|NM_176876.2	NP_073625.1|NP_795345.1	Q9H244	P2Y12_HUMAN	purinergic receptor P2Y, G-protein coupled, 12	30					platelet activation	integral to membrane|plasma membrane	guanyl-nucleotide exchange factor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)	17			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)		Clopidogrel(DB00758)|Epoprostenol(DB01240)|Ticlopidine(DB00208)|Treprostinil(DB00374)	GTGTAGAGCAGTGGGAAGAGG	0.443000													9	42					0	0	1	0	0
ARID1A	8289	broad.mit.edu	37	1	27106387	27106387	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:27106387G>C	ENST00000324856.7	+	20	6369	c.5998G>C	c.(5998-6000)Gag>Cag	p.E2000Q	ARID1A_ENST00000374152.2_Missense_Mutation_p.E1617Q|ARID1A_ENST00000540690.1_Missense_Mutation_p.E328Q|ARID1A_ENST00000457599.2_Missense_Mutation_p.E1783Q	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	2000					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CAATGACTTTGAGATGTCCAA	0.527000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								18	48					0	0	1	0	0
HID1	283987	broad.mit.edu	37	17	72954796	72954796	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr17:72954796G>C	ENST00000425042.2	-	10	1289	c.1212C>G	c.(1210-1212)ttC>ttG	p.F404L		NM_030630.2	NP_085133.1			HID1 domain containing																		CGTTGAGGAAGAAGAGGATGG	0.612000											OREG0024721	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	26					0	0	1	0	0
PLXNA1	5361	broad.mit.edu	37	3	126708422	126708422	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:126708422G>A	ENST00000251772.4	+	1	986	c.917G>A	c.(916-918)gGc>gAc	p.G306D	PLXNA1_ENST00000393409.2_Missense_Mutation_p.G329D			Q9UIW2	PLXA1_HUMAN	plexin A1	329	Sema.				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			breast(3)|central_nervous_system(5)|endometrium(10)|kidney(5)|large_intestine(4)|lung(32)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	67				GBM - Glioblastoma multiforme(114;0.155)		CACCAGCTGGGCCTGGCTGAG	0.657000													24	86					0	0	1	0	0
CACNA1I	8911	broad.mit.edu	37	22	39996539	39996539	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr22:39996539C>T	ENST00000336649.4	+	5	363	c.363C>T	c.(361-363)ttC>ttT	p.F121F	CACNA1I_ENST00000400164.3_Silent_p.F121F|CACNA1I_ENST00000404898.1_Silent_p.F121F|CACNA1I_ENST00000402142.3_Silent_p.F121F|CACNA1I_ENST00000401624.1_Silent_p.F121F|CACNA1I_ENST00000407673.1_Silent_p.F121F			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	121					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	TTGATGACTTCATCTTTATCT	0.567000													11	30					0	0	1	0	0
DUSP9	1852	broad.mit.edu	37	X	152915626	152915626	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:152915626G>T	ENST00000342782.3	+	4	1286	c.1021G>T	c.(1021-1023)Gag>Tag	p.E341*	DUSP9_ENST00000370167.4_Nonsense_Mutation_p.E341*			Q99956	DUS9_HUMAN	dual specificity phosphatase 9	341	Tyrosine-protein phosphatase.				inactivation of MAPK activity|JNK cascade	cytosol|endoplasmic reticulum|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|prostate(1)	16	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GCTGGACTTTGAGCGCAGCTT	0.607000													50	75					1.32667e-27	1.4804e-27	1	1	0
APOBEC4	403314	broad.mit.edu	37	1	183616819	183616819	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:183616819C>G	ENST00000308641.4	-	2	1369	c.1098G>C	c.(1096-1098)aaG>aaC	p.K366N	RGL1_ENST00000536277.1_Intron|APOBEC4_ENST00000481562.1_5'UTR|RGL1_ENST00000304685.4_Intron	NM_203454.2	NP_982279.1	Q8WW27	ABEC4_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)	366					mRNA processing		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|zinc ion binding			NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(6)|skin(1)	21						GATTTTATTTCTTCCCTTTCT	0.413000													17	95					0	0	1	0	0
CLP1	10978	broad.mit.edu	37	11	57426946	57426946	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:57426946G>A	ENST00000529430.1	+	2	85	c.31G>A	c.(31-33)Gag>Aag	p.E11K	CLP1_ENST00000533682.1_5'UTR|CLP1_ENST00000302731.4_5'UTR|CLP1_ENST00000525602.1_5'UTR			Q92989	CLP1_HUMAN	cleavage and polyadenylation factor I subunit 1	0					mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|siRNA loading onto RISC involved in RNA interference|targeting of mRNA for destruction involved in RNA interference|termination of RNA polymerase II transcription|tRNA splicing, via endonucleolytic cleavage and ligation	nucleoplasm|tRNA-intron endonuclease complex	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|stomach(1)	15						CTACACAGAAGAGATGGGAGA	0.428000													4	32					0	0	1	0	0
ANAPC1	64682	broad.mit.edu	37	2	112605344	112605344	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:112605344G>T	ENST00000341068.3	-	15	2521	c.1749C>A	c.(1747-1749)taC>taA	p.Y583*		NM_022662.3	NP_073153.1	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	583					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(7)|lung(16)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	49						TAGAATGAATGTAAGTTCCAA	0.403000													57	140					1.17253e-29	1.30991e-29	1	1	0
HOXA10	3206	broad.mit.edu	37	7	27213894	27213894	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:27213894G>A	ENST00000283921.4	-	1	31	c.32C>T	c.(31-33)tCg>tTg	p.S11L	RP1-170O19.20_ENST00000470747.4_Intron|HOXA10_ENST00000396344.4_Intron|RP1-170O19.20_ENST00000465941.1_Intron	NM_018951.3	NP_061824.3	P31260	HXA10_HUMAN	homeobox A10	11					spermatogenesis		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	9						ATAATTTGGCGAAGGGAGCAG	0.587000													28	46					0	0	1	0	0
MYO1G	64005	broad.mit.edu	37	7	45009674	45009674	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:45009674C>G	ENST00000258787.7	-	10	1433	c.1297G>C	c.(1297-1299)Gaa>Caa	p.E433Q		NM_033054.2	NP_149043.2	B0I1T2	MYO1G_HUMAN	myosin IG	433	Myosin head-like.					myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|pancreas(1)|skin(4)	28						TCGTACTCTTCCTGTTCCTGC	0.612000													4	16					0	0	1	0	0
UGT1A1	54658	broad.mit.edu	37	2	234669410	234669410	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:234669410C>G	ENST00000360418.3	+	1	477	c.477C>G	c.(475-477)atC>atG	p.I159M	UGT1A6_ENST00000373424.1_Intron|UGT1A3_ENST00000482026.1_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A1_ENST00000608381.1_Intron|UGT1A1_ENST00000609767.1_Intron|UGT1A8_ENST00000305208.5_Missense_Mutation_p.I159M|UGT1A1_ENST00000608383.1_Missense_Mutation_p.I159M|UGT1A4_ENST00000373409.3_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A6_ENST00000305139.6_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A1_ENST00000373450.4_Intron|UGT1A1_ENST00000609637.1_Intron|UGT1A5_ENST00000373414.3_Intron|UGT1A6_ENST00000406651.1_Intron			P22309	UD11_HUMAN		159					bilirubin conjugation|digestion|estrogen metabolic process|flavone metabolic process|heme catabolic process	endoplasmic reticulum membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding|steroid binding			breast(1)|central_nervous_system(2)|endometrium(7)|large_intestine(5)|lung(9)|skin(4)|urinary_tract(2)	30		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;4.1e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000435)|Lung(119;0.00211)|LUSC - Lung squamous cell carcinoma(224;0.0054)	Abacavir(DB01048)|Adenine(DB00173)|Diclofenac(DB00586)|Estradiol(DB00783)|Ezetimibe(DB00973)|Irinotecan(DB00762)|Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|Propofol(DB00818)|Rifampin(DB01045)|Troglitazone(DB00197)	GCAGCCCCATCGTGGCCCAGT	0.557000													23	103					0	0	1	0	0
PDCD11	22984	broad.mit.edu	37	10	105164886	105164886	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr10:105164886G>A	ENST00000369797.3	+	5	604	c.510G>A	c.(508-510)ctG>ctA	p.L170L		NM_014976.1	NP_055791.1	Q14690	RRP5_HUMAN	programmed cell death 11	170	S1 motif 1.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	64		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		AGCTGTCTCTGAACCCCAAAA	0.527000													16	30					0	0	1	0	0
ZBTB7B	51043	broad.mit.edu	37	1	154988247	154988247	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:154988247G>A	ENST00000368426.3	+	3	1248	c.1111G>A	c.(1111-1113)Gag>Aag	p.E371K	ZBTB7B_ENST00000535420.1_Missense_Mutation_p.E371K|ZBTB7B_ENST00000292176.2_Missense_Mutation_p.E371K|ZBTB7B_ENST00000417934.2_Missense_Mutation_p.E405K	NM_001256455.1	NP_001243384.1	O15156	ZBT7B_HUMAN	zinc finger and BTB domain containing 7B	371					cell differentiation|ectoderm development|multicellular organismal development|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(1)|prostate(3)|skin(3)	29	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			CCACACAGGCGAGAAGCCCTT	0.647000													16	61					0	0	1	0	0
RBAK	57786	broad.mit.edu	37	7	5104216	5104216	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:5104216G>A	ENST00000396912.1	+	5	1648	c.1129G>A	c.(1129-1131)Gaa>Aaa	p.E377K	RBAK-RBAKDN_ENST00000396904.2_Intron|RBAK-RBAKDN_ENST00000407184.1_Intron|RBAK_ENST00000353796.3_Missense_Mutation_p.E377K	NM_021163.3	NP_066986.1	Q9NYW8	RBAK_HUMAN	RB-associated KRAB zinc finger	377					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			NS(1)|kidney(1)|large_intestine(2)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)	10		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0916)|OV - Ovarian serous cystadenocarcinoma(56;2.44e-14)		TCCATGTAACGAATGTGGGAA	0.468000													48	59					0	0	1	0	0
EXOC2	55770	broad.mit.edu	37	6	553871	553871	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:553871C>G	ENST00000230449.4	-	21	2239	c.2104G>C	c.(2104-2106)Gac>Cac	p.D702H	EXOC2_ENST00000448181.3_Missense_Mutation_p.D297H	NM_018303.5	NP_060773.3	Q96KP1	EXOC2_HUMAN	exocyst complex component 2	702					exocytosis|protein transport					breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|liver(1)|lung(16)|ovary(4)|pancreas(1)|prostate(2)	46	Ovarian(93;0.0733)	Breast(5;0.0014)|all_lung(73;0.0697)|all_hematologic(90;0.0897)		OV - Ovarian serous cystadenocarcinoma(45;0.0507)|BRCA - Breast invasive adenocarcinoma(62;0.14)		AAGCTGAAGTCTTCATGGATA	0.368000													7	66					0	0	1	0	0
GLCE	26035	broad.mit.edu	37	15	69548288	69548288	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr15:69548288G>C	ENST00000261858.2	+	3	371	c.143G>C	c.(142-144)aGa>aCa	p.R48T	GLCE_ENST00000559420.2_5'UTR	NM_015554.1	NP_056369.1	O94923	GLCE_HUMAN	glucuronic acid epimerase	48					heparan sulfate proteoglycan biosynthetic process|heparin biosynthetic process	Golgi membrane|integral to membrane	UDP-glucuronate 5'-epimerase activity			NS(1)|breast(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	18						AGTGGCTTCAGAGTGGATGGG	0.458000													11	60					0	0	1	0	0
TBC1D5	9779	broad.mit.edu	37	3	17279814	17279814	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:17279814T>A	ENST00000253692.7	-	17	3093	c.1429A>T	c.(1429-1431)Agt>Tgt	p.S477C	TBC1D5_ENST00000429924.2_Missense_Mutation_p.S429C|TBC1D5_ENST00000414318.2_5'UTR|TBC1D5_ENST00000429383.4_Missense_Mutation_p.S477C|TBC1D5_ENST00000446818.2_Missense_Mutation_p.S477C	NM_014744.2	NP_055559.1	Q92609	TBCD5_HUMAN	TBC1 domain family, member 5	477						intracellular	protein binding|Rab GTPase activator activity			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	36						CCACCTGCACTGCCTGGAGCC	0.502000													13	38					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39798399	39798399	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:39798399C>G	ENST00000564288.1	+	37	6916	c.6139C>G	c.(6139-6141)Cag>Gag	p.Q2047E	MACF1_ENST00000567887.1_Missense_Mutation_p.Q2084E|MACF1_ENST00000289893.4_Missense_Mutation_p.Q487E|MACF1_ENST00000545844.1_Intron|MACF1_ENST00000361689.2_Intron|MACF1_ENST00000372915.3_Missense_Mutation_p.Q2052E|MACF1_ENST00000539005.1_Intron|MACF1_ENST00000476350.1_Intron|MACF1_ENST00000317713.7_Intron			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	2052					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GTTTTCTTCTCAGAACAAAGA	0.433000													3	59					0	0	1	0	0
ITGAX	3687	broad.mit.edu	37	16	31391162	31391162	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr16:31391162G>A	ENST00000268296.4	+	25	3074	c.2953G>A	c.(2953-2955)Gat>Aat	p.D985N	ITGAX_ENST00000562522.1_Missense_Mutation_p.D985N	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	985					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						TGTGTGGATGGATGTGGAGGT	0.587000													5	13					0	0	1	0	0
ZEB1	6935	broad.mit.edu	37	10	31799699	31799699	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr10:31799699G>A	ENST00000446923.2	+	5	923	c.532G>A	c.(532-534)Gaa>Aaa	p.E178K	ZEB1_ENST00000559858.1_3'UTR|ZEB1_ENST00000320985.10_Missense_Mutation_p.E194K|ZEB1_ENST00000361642.5_Missense_Mutation_p.E195K|ZEB1_ENST00000560721.2_Missense_Mutation_p.E174K|ZEB1_ENST00000542815.3_Missense_Mutation_p.E127K	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	194					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				ATATCGTCATGAAAAGAATGA	0.383000													13	72					0	0	1	0	0
C12orf55	144535	broad.mit.edu	37	12	97045378	97045378	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:97045378C>G	ENST00000524981.4	+	36	4908	c.4885C>G	c.(4885-4887)Cgt>Ggt	p.R1629G						chromosome 12 open reading frame 55																		TCTTGCTCATCGTGGTGGCTA	0.378000													15	40					0	0	1	0	0
SAMD9	54809	broad.mit.edu	37	7	92731759	92731759	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:92731759C>G	ENST00000379958.2	-	3	3921	c.3652G>C	c.(3652-3654)Gat>Cat	p.D1218H		NM_001193307.1|NM_017654.3	NP_001180236.1|NP_060124.2	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	1218						cytoplasm				NS(1)|breast(4)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(20)|lung(32)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	88	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			TTTTTATTATCAAAAAAAGGA	0.338000													38	64					0	0	1	0	0
THAP7-AS1	439931	broad.mit.edu	37	22	21363359	21363359	+	RNA	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr22:21363359G>C	ENST00000452284.1	+	0	1026				TUBA3FP_ENST00000422086.1_RNA|THAP7-AS1_ENST00000436079.1_RNA	NR_027051.1																						AGTTGGTTTGGAATTCTGTCA	0.577000													11	28					0	0	1	0	0
PCNXL4	64430	broad.mit.edu	37	14	60590987	60590987	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr14:60590987G>C	ENST00000406854.1	+	9	2652	c.2098G>C	c.(2098-2100)Gat>Cat	p.D700H	PCNXL4_ENST00000535349.1_5'UTR|PCNXL4_ENST00000404681.2_Missense_Mutation_p.D700H|PCNXL4_ENST00000317623.4_Missense_Mutation_p.D466H|PCNXL4_ENST00000406949.1_Missense_Mutation_p.D466H					pecanex-like 4 (Drosophila)																		TCGCAGAGTTGATGAAGTTTT	0.353000													4	9					0	0	1	0	0
GPRIN1	114787	broad.mit.edu	37	5	176023997	176023997	+	Missense_Mutation	SNP	C	C	G	rs147780512		TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr5:176023997C>G	ENST00000303991.4	-	2	3016	c.2839G>C	c.(2839-2841)Gag>Cag	p.E947Q		NM_052899.2	NP_443131.2	Q7Z2K8	GRIN1_HUMAN	G protein regulated inducer of neurite outgrowth 1	947	Interaction with GNAO1 (By similarity).					growth cone|plasma membrane		p.E947Q(1)		NS(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|liver(1)|lung(15)|ovary(2)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(89;0.00263)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCGTGCTCCTCGATCTGTCGC	0.746000													6	16					0	0	1	0	0
ASTN2	23245	broad.mit.edu	37	9	119738401	119738401	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr9:119738401C>G	ENST00000313400.4	-	9	1843	c.1743G>C	c.(1741-1743)aaG>aaC	p.K581N	ASTN2_ENST00000361477.3_5'UTR|ASTN2_ENST00000361209.2_Missense_Mutation_p.K530N|ASTN2_ENST00000373996.3_Missense_Mutation_p.K581N			O75129	ASTN2_HUMAN	astrotactin 2	581						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						ACCTGAGAATCTTTTCAGGGG	0.493000													8	12					0	0	1	0	0
ZNF107	51427	broad.mit.edu	37	7	64167368	64167368	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:64167368C>T	ENST00000395391.1	+	4	2061	c.686C>T	c.(685-687)tCa>tTa	p.S229L	ZNF107_ENST00000344930.3_Missense_Mutation_p.S229L|ZNF107_ENST00000423627.1_Missense_Mutation_p.S229L			Q9UII5	ZN107_HUMAN	zinc finger protein 107	229					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(18)|ovary(1)|stomach(1)	37		Lung NSC(55;0.00948)|all_lung(88;0.0249)				AGCCAGTCCTCACACCTTACT	0.358000													21	58					0	0	1	0	0
NLRP12	91662	broad.mit.edu	37	19	54327330	54327330	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:54327330C>T	ENST00000324134.6	-	1	267	c.99G>A	c.(97-99)ggG>ggA	p.G33G	NLRP12_ENST00000345770.5_Silent_p.G33G|NLRP12_ENST00000351894.4_Silent_p.G33G|NLRP12_ENST00000391773.1_Silent_p.G33G|NLRP12_ENST00000354278.3_Silent_p.G33G|NLRP12_ENST00000391772.1_Silent_p.G33G|NLRP12_ENST00000391775.3_Silent_p.G33G|NLRP12_ENST00000535162.1_Silent_p.G33G	NM_001277126.1|NM_144687.2	NP_001264055.1|NP_653288.1	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12	33	DAPIN.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(36)|ovary(5)|pancreas(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	80	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		CTGTCGCGGTCCCCAGGTATA	0.602000													11	63					0	0	1	0	0
SMG5	23381	broad.mit.edu	37	1	156238196	156238196	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:156238196C>G	ENST00000361813.5	-	8	868	c.724G>C	c.(724-726)Gaa>Caa	p.E242Q	SMG5_ENST00000368267.5_Missense_Mutation_p.E242Q	NM_015327.2	NP_056142.2	Q9UPR3	SMG5_HUMAN	SMG5 nonsense mediated mRNA decay factor	242					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			NS(1)|breast(3)|endometrium(8)|kidney(2)|large_intestine(7)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	48	Hepatocellular(266;0.158)					AAGGACACTTCTGACTGGATG	0.478000													77	93					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124390626	124390626	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:124390626G>A	ENST00000291478.5	+	15	1892	c.1729G>A	c.(1729-1731)Gag>Aag	p.E577K	KALRN_ENST00000360013.3_Missense_Mutation_p.E2274K|KALRN_ENST00000459915.1_Missense_Mutation_p.E366K|KALRN_ENST00000393496.1_Missense_Mutation_p.E615K|KALRN_ENST00000428018.2_Missense_Mutation_p.E545K	NM_007064.3	NP_008995.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase						apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						TGCGGGCTCAGAGAAGCCCCC	0.577000													18	69					0	0	1	0	0
ICK	22858	broad.mit.edu	37	6	52884028	52884028	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:52884028C>G	ENST00000356971.3	-	7	977	c.488G>C	c.(487-489)aGa>aCa	p.R163T	ICK_ENST00000350082.5_Missense_Mutation_p.R163T	NM_016513.4	NP_057597.2	Q9UPZ9	ICK_HUMAN	intestinal cell (MAK-like) kinase	163	Protein kinase.				intracellular protein kinase cascade|multicellular organismal development	cytosol|nucleus	ATP binding|cyclin-dependent protein kinase activity|magnesium ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(3)|stomach(1)	31	Lung NSC(77;0.103)					TATTCACCATCTGGTAGATAC	0.328000													11	47					0	0	1	0	0
ADAM22	53616	broad.mit.edu	37	7	87759715	87759715	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:87759715C>T	ENST00000398204.4	+	10	1089	c.766C>T	c.(766-768)Cgg>Tgg	p.R256W	ADAM22_ENST00000265727.7_Missense_Mutation_p.R256W|ADAM22_ENST00000439864.1_Missense_Mutation_p.R256W|ADAM22_ENST00000398201.4_Missense_Mutation_p.R256W|ADAM22_ENST00000398209.3_Missense_Mutation_p.R256W|ADAM22_ENST00000315984.7_Missense_Mutation_p.R256W	NM_016351.4|NM_021723.3	NP_057435.2|NP_068369.1	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22	256	Peptidase M12B.				cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			endometrium(7)|kidney(4)|large_intestine(7)|liver(2)|lung(20)|ovary(6)|prostate(4)|skin(3)	53	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			TAAAAAACATCGGCTTTCCGT	0.368000													12	71					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	137814238	137814238	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:137814238G>C	ENST00000409968.1	+	3	566	c.388G>C	c.(388-390)Gag>Cag	p.E130Q	THSD7B_ENST00000272643.3_Missense_Mutation_p.E130Q|THSD7B_ENST00000413152.2_Missense_Mutation_p.E99Q					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		TCGGACTGCAGAGTGTGTGAC	0.537000													20	37					0	0	1	0	0
KANK4	163782	broad.mit.edu	37	1	62728770	62728770	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:62728770C>G	ENST00000371153.4	-	7	2911	c.2533G>C	c.(2533-2535)Gag>Cag	p.E845Q	KANK4_ENST00000317477.4_5'UTR|KANK4_ENST00000371150.1_Missense_Mutation_p.E201Q|KANK4_ENST00000354381.3_Missense_Mutation_p.E217Q	NM_181712.4	NP_859063.3	Q5T7N3	KANK4_HUMAN	KN motif and ankyrin repeat domains 4	845										NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(49)|ovary(3)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	81						TGACCTGTCTCCAGCAGCAGC	0.463000													4	11					0	0	1	0	0
ZIC5	85416	broad.mit.edu	37	13	100617675	100617675	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr13:100617675C>G	ENST00000267294.4	-	2	2181	c.1948G>C	c.(1948-1950)Gag>Cag	p.E650Q		NM_033132.3	NP_149123.2	Q96T25	ZIC5_HUMAN	Zic family member 5	650					cell differentiation	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(1)|lung(2)|prostate(1)|skin(2)	9	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TAAATTTCCTCATCTTCAGTC	0.478000													22	59					0	0	1	0	0
PCDHA2	56146	broad.mit.edu	37	5	140175795	140175795	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr5:140175795G>T	ENST00000526136.1	+	1	1246	c.1246G>T	c.(1246-1248)Gag>Tag	p.E416*	PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000378132.1_Nonsense_Mutation_p.E416*|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000520672.2_Nonsense_Mutation_p.E416*	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTGGACCGCGAGAGCGTGTC	0.627000													30	77					8.16721e-17	8.9886e-17	1	1	0
CCDC173	129881	broad.mit.edu	37	2	170502475	170502475	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:170502475C>G	ENST00000447353.1	-	9	1640	c.1535G>C	c.(1534-1536)aGa>aCa	p.R512T		NM_001085447.1	NP_001078916.1			coiled-coil domain containing 173																		TAATCCACCTCTGTCCACAAA	0.408000													40	73					0	0	1	0	0
FEN1	2237	broad.mit.edu	37	11	61563671	61563671	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:61563671C>T	ENST00000305885.2	+	2	1251	c.838C>T	c.(838-840)Cac>Tac	p.H280Y	FADS2_ENST00000574708.1_Intron	NM_004111.5	NP_004102.1	P39748	FEN1_HUMAN	flap structure-specific endonuclease 1	280					base-excision repair|DNA replication, removal of RNA primer|double-strand break repair|phosphatidylinositol-mediated signaling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|UV protection	mitochondrion|nucleolus|nucleoplasm	5'-3' exonuclease activity|5'-flap endonuclease activity|damaged DNA binding|double-stranded DNA binding|double-stranded DNA specific exodeoxyribonuclease activity|metal ion binding|protein binding|ribonuclease H activity			endometrium(1)|large_intestine(4)|lung(1)|ovary(1)	7						CAAGGAGGCTCACCAGCTCTT	0.537000								Editing and processing nucleases					4	19					0	0	1	0	0
IDI2	91734	broad.mit.edu	37	10	1070541	1070541	+	Silent	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr10:1070541C>G	ENST00000277517.1	-	2	187	c.123G>C	c.(121-123)ctG>ctC	p.L41L	IDI2-AS1_ENST00000428780.2_RNA|IDI2-AS1_ENST00000437374.1_RNA|IDI2-AS1_ENST00000420381.1_RNA|IDI2-AS1_ENST00000536039.1_RNA|IDI2-AS1_ENST00000434470.1_RNA	NM_033261.2	NP_150286.1	Q9BXS1	IDI2_HUMAN	isopentenyl-diphosphate delta isomerase 2	41					carotenoid biosynthetic process|cholesterol biosynthetic process	cytosol|peroxisome	hydrolase activity|isopentenyl-diphosphate delta-isomerase activity|metal ion binding			kidney(1)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	9		Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.143)	Epithelial(11;0.067)|OV - Ovarian serous cystadenocarcinoma(14;0.169)|all cancers(11;0.192)		TGTTTTCGTTCAGATGGCAAT	0.498000													10	44					0	0	1	0	0
ERCC2	2068	broad.mit.edu	37	19	45862128	45862128	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:45862128G>C	ENST00000485403.2	-	12	1426	c.1208C>G	c.(1207-1209)tCt>tGt	p.S403C	ERCC2_ENST00000391945.4_Intron|ERCC2_ENST00000391940.4_Missense_Mutation_p.S403C|ERCC2_ENST00000391944.3_Intron	NM_001130867.1	NP_001124339.1	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 2	0					cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			large_intestine(4)|lung(2)|ovary(1)|pancreas(1)|stomach(1)	9		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		ttagggatgagatcttttttg	0.398000			"""Mis, N, F, S"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				12	29					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124332536	124332536	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:124332536C>T	ENST00000409039.3	+	32	5514	c.5489C>T	c.(5488-5490)cCc>cTc	p.P1830L		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1830	AAA 1 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GGTGGGGCCCCCGCCGGCCCA	0.532000													5	75					0	0	1	0	0
BMPER	168667	broad.mit.edu	37	7	34006100	34006100	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:34006100A>G	ENST00000297161.2	+	5	703	c.329A>G	c.(328-330)tAt>tGt	p.Y110C	BMPER_ENST00000426693.1_Missense_Mutation_p.Y110C	NM_133468.4	NP_597725.1	Q8N8U9	BMPER_HUMAN	BMP binding endothelial regulator	110	VWFC 2.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(24)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48						GGTTGCACCTATGAAGGAAAT	0.448000													8	55					0	0	1	0	0
CEP290	80184	broad.mit.edu	37	12	88452740	88452740	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:88452740C>T	ENST00000552810.1	-	49	7046	c.6703G>A	c.(6703-6705)Gag>Aag	p.E2235K	CEP290_ENST00000397838.3_Missense_Mutation_p.E1295K|CEP290_ENST00000547691.2_Missense_Mutation_p.E1295K|CEP290_ENST00000309041.7_Missense_Mutation_p.E2237K	NM_025114.3	NP_079390.3	O15078	CE290_HUMAN	centrosomal protein 290kDa	2235					cilium assembly|eye photoreceptor cell development|G2/M transition of mitotic cell cycle|hindbrain development|otic vesicle formation|positive regulation of transcription, DNA-dependent|pronephros development|protein transport	cell surface|centrosome|cytosol|nucleus|photoreceptor connecting cilium	protein binding			breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|liver(1)|lung(18)|ovary(5)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	73						GTCATCTTCTCATTTAATATC	0.353000													3	39					0	0	1	0	0
MKL1	57591	broad.mit.edu	37	22	40820226	40820226	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr22:40820226G>C	ENST00000396617.3	-	8	1051	c.461C>G	c.(460-462)tCt>tGt	p.S154C	MKL1_ENST00000355630.3_Missense_Mutation_p.S154C|MKL1_ENST00000407029.1_Missense_Mutation_p.S154C|MKL1_ENST00000402042.1_Missense_Mutation_p.S154C	NM_001282662.1	NP_001269591.1	Q969V6	MKL1_HUMAN	megakaryoblastic leukemia (translocation) 1	154	Mediates interaction with SCAI and ACTB (By similarity).				positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(13)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	30						GGGGGATGCAGAGGTGGCACT	0.637000			T	RBM15	acute megakaryocytic leukemia								58	87					0	0	1	0	0
SPAG8	26206	broad.mit.edu	37	9	35809936	35809936	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr9:35809936C>T	ENST00000484764.1	-	7	1473	c.1433G>A	c.(1432-1434)tGa>tAa	p.*478*	SPAG8_ENST00000340291.2_Intron|SPAG8_ENST00000479751.1_5'UTR|SPAG8_ENST00000396638.2_Silent_p.*486*			Q99932	SPAG8_HUMAN	sperm associated antigen 8	0						acrosomal vesicle|membrane				NS(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(1)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)			CCTCACCCCTCAGAAAGGAGT	0.498000													13	96					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179393141	179393141	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:179393141G>A	ENST00000589042.1	-	361	107461	c.107237C>T	c.(107236-107238)tCa>tTa	p.S35746L	TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.S33178L|TTN_ENST00000342175.6_Missense_Mutation_p.S26873L|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000588804.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.S26806L|TTN-AS1_ENST00000589434.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000585487.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.S26681L|TTN_ENST00000591111.1_Missense_Mutation_p.S34105L|TTN-AS1_ENST00000442329.2_RNA|TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000604571.1_RNA|TTN-AS1_ENST00000585625.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000431259.2_RNA|TTN-AS1_ENST00000592182.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000587568.1_RNA|TTN-AS1_ENST00000456053.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	34105							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTGACATTTGAAGAAATAGA	0.338000													6	30					0	0	1	0	0
DRG2	1819	broad.mit.edu	37	17	18003719	18003719	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr17:18003719C>T	ENST00000225729.3	+	6	648	c.510C>T	c.(508-510)ctC>ctT	p.L170L	DRG2_ENST00000395726.4_Silent_p.L170L|DRG2_ENST00000583355.1_Intron	NM_001388.4	NP_001379.1	P55039	DRG2_HUMAN	developmentally regulated GTP binding protein 2	170	G.				signal transduction		GTP binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	14	all_neural(463;0.228)					GCATCCGCCTCAACAAGCACA	0.577000													15	58					0	0	1	0	0
CPSF3	51692	broad.mit.edu	37	2	9580774	9580774	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:9580774C>G	ENST00000460593.1	+	8	1942	c.804C>G	c.(802-804)ttC>ttG	p.F268L	CPSF3_ENST00000238112.3_Missense_Mutation_p.F305L			Q9UKF6	CPSF3_HUMAN	cleavage and polyadenylation specific factor 3, 73kDa	305					histone mRNA 3'-end processing|mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex|ribonucleoprotein complex	5'-3' exonuclease activity|endoribonuclease activity|metal ion binding|protein binding|RNA binding			NS(1)|breast(3)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)	all_cancers(51;2.39e-25)|all_epithelial(98;8.75e-19)|Lung NSC(108;2.38e-06)|Ovarian(717;0.0308)		all cancers(51;2.2e-40)|Epithelial(75;6.71e-35)|OV - Ovarian serous cystadenocarcinoma(76;4.35e-21)|STAD - Stomach adenocarcinoma(1183;0.00644)		CCTTTGTTTTCAAACACATTA	0.408000													18	66					0	0	1	0	0
IGKV1D-8	28904	broad.mit.edu	37	2	90259814	90259814	+	RNA	SNP	T	T	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:90259814T>A	ENST00000471857.1	+	0	222																											GGGCTCCTGCTGCTCTGGCTC	0.522000													21	188					0	0	1	0	0
RAB36	9609	broad.mit.edu	37	22	23495229	23495229	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr22:23495229G>C	ENST00000263116.2	+	5	475	c.435G>C	c.(433-435)aaG>aaC	p.K145N	RAB36_ENST00000341989.4_Missense_Mutation_p.K123N	NM_004914.2	NP_004905.2	O95755	RAB36_HUMAN	RAB36, member RAS oncogene family	145					protein transport|small GTPase mediated signal transduction	Golgi membrane	GTP binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.155)		GGTTTTGCAAGAATGTTTTTG	0.468000													12	70					0	0	1	0	0
MGARP	84709	broad.mit.edu	37	4	140187920	140187920	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr4:140187920C>G	ENST00000398955.1	-	4	735	c.556G>C	c.(556-558)Gaa>Caa	p.E186Q		NM_032623.3	NP_116012.2	Q8TDB4	CD049_HUMAN	mitochondria-localized glutamic acid-rich protein	186						integral to membrane											GTGACAGCTTCATCCAGGGCA	0.473000													42	163					0	0	1	0	0
CYR61	3491	broad.mit.edu	37	1	86047730	86047730	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:86047730C>T	ENST00000451137.2	+	3	621	c.397C>T	c.(397-399)Ctg>Ttg	p.L133L	CYR61_ENST00000480413.1_3'UTR	NM_001554.4	NP_001545.2	O00622	CYR61_HUMAN	cysteine-rich, angiogenic inducer, 61	133	VWFC.				cell proliferation|chemotaxis|positive regulation of BMP signaling pathway|positive regulation of cell migration|positive regulation of osteoblast differentiation|positive regulation of osteoblast proliferation|positive regulation of protein kinase activity|positive regulation of protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell growth|regulation of ERK1 and ERK2 cascade|wound healing, spreading of cells	extracellular region	heparin binding|insulin-like growth factor binding			central_nervous_system(1)|endometrium(1)|large_intestine(2)|prostate(1)	5				all cancers(265;0.0216)|Epithelial(280;0.0441)		CTGCATTCCTCTGTGTCCCCA	0.532000											OREG0013583	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	125					0	0	1	0	0
LINC00471	151477	broad.mit.edu	37	2	232378279	232378279	+	RNA	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:232378279C>G	ENST00000313064.2	-	0	322					NR_024079.1																						GACATCTCATCTTCCCCATCT	0.358000													5	51					0	0	1	0	0
GPR31	2853	broad.mit.edu	37	6	167570935	167570935	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:167570935G>A	ENST00000366834.1	-	1	882	c.385C>T	c.(385-387)Cag>Tag	p.Q129*		NM_005299.2	NP_005290.2	O00270	GPR31_HUMAN	G protein-coupled receptor 31	129						integral to plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(4)|large_intestine(4)|lung(7)|prostate(1)	17		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;4.81e-20)|BRCA - Breast invasive adenocarcinoma(81;4.45e-06)|GBM - Glioblastoma multiforme(31;0.00492)		AGGGCCGCCTGAGGAGACAGC	0.682000													11	17					0	0	1	0	0
GPR18	2841	broad.mit.edu	37	13	99908020	99908020	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr13:99908020C>G	ENST00000340807.3	-	3	663	c.107G>C	c.(106-108)gGa>gCa	p.G36A	GPR18_ENST00000397470.2_Missense_Mutation_p.G36A|GPR18_ENST00000397473.2_Missense_Mutation_p.G36A|UBAC2_ENST00000403766.3_Intron|UBAC2_ENST00000376440.2_Intron			Q14330	GPR18_HUMAN	G protein-coupled receptor 18	36						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(2)|large_intestine(2)|lung(6)	10	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Glycine(DB00145)	AACAAATAATCCAATTATGAA	0.388000													22	45					0	0	1	0	0
AKAP9	10142	broad.mit.edu	37	7	91706275	91706275	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:91706275C>G	ENST00000359028.2	+	30	6980	c.6755C>G	c.(6754-6756)tCt>tGt	p.S2252C	AKAP9_ENST00000356239.3_Missense_Mutation_p.S2240C|AKAP9_ENST00000358100.2_Missense_Mutation_p.S2252C			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	2252	Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AAAAAGGAATCTACTACCCGC	0.289000			T	BRAF	papillary thyroid								25	48					0	0	1	0	0
DHTKD1	55526	broad.mit.edu	37	10	12148393	12148393	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr10:12148393G>C	ENST00000263035.4	+	11	2107	c.2045G>C	c.(2044-2046)gGa>gCa	p.G682A		NM_018706.5	NP_061176	Q96HY7	DHTK1_HUMAN	dehydrogenase E1 and transketolase domain containing 1	682					glycolysis	mitochondrion	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(1)	44		Renal(717;0.228)	BRCA - Breast invasive adenocarcinoma(52;0.188)			TTCATCTCTGGAGGTTGGTGT	0.557000													84	61					0	0	1	0	0
NF2	4771	broad.mit.edu	37	22	30064420	30064420	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr22:30064420G>A	ENST00000338641.4	+	10	1425	c.984G>A	c.(982-984)gaG>gaA	p.E328E	NF2_ENST00000413209.2_Intron|NF2_ENST00000403435.1_Silent_p.E328E|NF2_ENST00000353887.4_Silent_p.E245E|NF2_ENST00000361166.4_Silent_p.E328E|NF2_ENST00000403999.3_Silent_p.E328E|NF2_ENST00000334961.7_Silent_p.E245E|NF2_ENST00000361676.4_Silent_p.E286E|NF2_ENST00000347330.5_Silent_p.E169E|NF2_ENST00000361452.4_Silent_p.E287E|NF2_ENST00000397789.3_Silent_p.E328E	NM_000268.3|NM_016418.5|NM_181832.2	NP_000259.1|NP_057502.2|NP_861970.1	P35240	MERL_HUMAN	neurofibromin 2 (merlin)	328	Glu-rich.				actin cytoskeleton organization|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of cell-matrix adhesion|negative regulation of DNA replication|negative regulation of tyrosine phosphorylation of Stat3 protein|negative regulation of tyrosine phosphorylation of Stat5 protein|positive regulation of stress fiber assembly|regulation of hippo signaling cascade|Schwann cell proliferation	cytoskeleton|early endosome|extrinsic to membrane|filopodium membrane|nucleolus|perinuclear region of cytoplasm|ruffle membrane	cytoskeletal protein binding|protein binding	p.?(4)|p.I296_Q333del(1)|p.Q324fs*12(1)		NS(1)|bone(2)|breast(5)|central_nervous_system(21)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(17)|large_intestine(9)|liver(1)|lung(9)|meninges(372)|ovary(2)|pituitary(1)|pleura(9)|prostate(1)|skin(7)|soft_tissue(303)|stomach(2)|thyroid(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	776						CCAGGGAGGAGAAGGCTAGAA	0.512000			"""D, Mis, N, F, S, O"""		"""meningioma, acoustic neuroma, renal """	"""meningioma, acoustic neuroma"""			Neurofibromatosis, type 2				11	16					0	0	1	0	0
NFYC	4802	broad.mit.edu	37	1	41236499	41236499	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:41236499G>A	ENST00000372652.1	+	10	1587	c.1319G>A	c.(1318-1320)tGa>tAa	p.*440*	NFYC_ENST00000372651.1_Silent_p.*336*|NFYC_ENST00000372654.1_Silent_p.*336*|NFYC_ENST00000440226.3_Silent_p.*336*|NFYC_ENST00000447388.3_Silent_p.*336*|NFYC_ENST00000308733.5_Silent_p.*459*|NFYC_ENST00000456393.2_Silent_p.*335*|NFYC_ENST00000425457.2_Silent_p.*355*|NFYC_ENST00000427410.2_Silent_p.*298*|NFYC_ENST00000372653.1_Silent_p.*302*			Q13952	NFYC_HUMAN	nuclear transcription factor Y, gamma	0					protein folding|regulation of transcription from RNA polymerase II promoter	CCAAT-binding factor complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(3)|lung(1)|prostate(1)|skin(2)	15	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.72e-17)			ACCGGCGACTGAGGGCCTGAG	0.657000													4	39					0	0	1	0	0
IQGAP2	10788	broad.mit.edu	37	5	75950813	75950813	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr5:75950813G>C	ENST00000274364.6	+	20	2602	c.2305G>C	c.(2305-2307)Gac>Cac	p.D769H	IQGAP2_ENST00000396234.3_Missense_Mutation_p.D265H|IQGAP2_ENST00000502745.1_Missense_Mutation_p.D265H|IQGAP2_ENST00000379730.3_Missense_Mutation_p.D271H	NM_006633.2	NP_006624	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	769	IQ 3.				small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(23)|ovary(6)|prostate(1)|skin(3)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	68		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		AGCTAGAGATGACTACAAAAC	0.393000													12	62					0	0	1	0	0
IGF2R	3482	broad.mit.edu	37	6	160506147	160506147	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:160506147G>C	ENST00000356956.1	+	41	6337	c.6189G>C	c.(6187-6189)caG>caC	p.Q2063H		NM_000876.2	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor	2063					receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			breast(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(27)|lung(31)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		TTCACACGCAGAAGCTGGGTG	0.552000													8	24					0	0	1	0	0
KEL	3792	broad.mit.edu	37	7	142658935	142658935	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:142658935C>G	ENST00000355265.2	-	2	502	c.28G>C	c.(28-30)Gag>Cag	p.E10Q	KEL_ENST00000479768.2_5'UTR	NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	10					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					TCCCTCGGCTCTTCCTCACTT	0.537000													33	139					0	0	1	0	0
ZNF543	125919	broad.mit.edu	37	19	57839842	57839842	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:57839842C>T	ENST00000321545.4	+	4	1357	c.1012C>T	c.(1012-1014)Ccc>Tcc	p.P338S		NM_213598.3	NP_998763.2	Q08ER8	ZN543_HUMAN	zinc finger protein 543	338					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|kidney(2)|large_intestine(8)|lung(11)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	28		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GGGAGAGAAGCCCTATGAGTG	0.507000													20	62					0	0	1	0	0
LCLAT1	253558	broad.mit.edu	37	2	30785065	30785065	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:30785065G>A	ENST00000309052.4	+	5	741	c.532G>A	c.(532-534)Gac>Aac	p.D178N	LCLAT1_ENST00000379509.3_Missense_Mutation_p.D140N|LCLAT1_ENST00000319406.4_Missense_Mutation_p.D178N|LCLAT1_ENST00000359433.1_Missense_Mutation_p.D178N|LCLAT1_ENST00000491680.2_3'UTR|LCLAT1_ENST00000540623.1_Missense_Mutation_p.D140N	NM_182551.3	NP_872357.2	Q6UWP7	LCLT1_HUMAN	lysocardiolipin acyltransferase 1	178					multicellular organismal development|phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(6)|ovary(2)	19						ATGGAAGGATGACAAGAGCCA	0.373000													22	63					0	0	1	0	0
FHOD1	29109	broad.mit.edu	37	16	67281174	67281174	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr16:67281174C>T	ENST00000258201.4	-	1	387	c.140G>A	c.(139-141)gGg>gAg	p.G47E		NM_013241.2	NP_037373.2	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	47					actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(4)|endometrium(3)|kidney(3)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	34		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		GGGCAGCGCCCCGTCCAGGCT	0.697000													8	4					0	0	1	0	0
RCVRN	5957	broad.mit.edu	37	17	9801509	9801509	+	Missense_Mutation	SNP	T	T	A	rs111535086		TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr17:9801509T>A	ENST00000226193.5	-	3	946	c.506A>T	c.(505-507)gAg>gTg	p.E169V	RCVRN_ENST00000570909.3_5'UTR	NM_002903.2	NP_002894.1	P35243	RECO_HUMAN	recoverin	169	EF-hand 4.				visual perception		calcium ion binding|calcium sensitive guanylate cyclase activator activity			endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|upper_aerodigestive_tract(1)	12						GAATTCTTTCTCTGTAAGTTT	0.418000													19	102					0	0	1	0	0
PTGFR	5737	broad.mit.edu	37	1	78959032	78959032	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:78959032C>G	ENST00000370756.3	+	2	841	c.604C>G	c.(604-606)Ctt>Gtt	p.L202V	PTGFR_ENST00000370758.1_Missense_Mutation_p.L202V|PTGFR_ENST00000370757.3_Missense_Mutation_p.L202V	NM_001039585.1	NP_001034674.1	P43088	PF2R_HUMAN	prostaglandin F receptor (FP)	202					parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity			breast(6)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	33				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)	TAGATTTTATCTTCTACTTTT	0.393000													10	74					0	0	1	0	0
VEGFA	7422	broad.mit.edu	37	6	43745253	43745253	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:43745253G>A	ENST00000372067.3	+	3	1200	c.706G>A	c.(706-708)Gag>Aag	p.E236K	VEGFA_ENST00000372055.4_Missense_Mutation_p.E236K|VEGFA_ENST00000518824.1_Missense_Mutation_p.E56K|VEGFA_ENST00000425836.2_Missense_Mutation_p.E236K|VEGFA_ENST00000324450.6_Missense_Mutation_p.E236K|VEGFA_ENST00000520948.1_Missense_Mutation_p.E56K|VEGFA_ENST00000417285.2_Missense_Mutation_p.E236K|VEGFA_ENST00000372064.4_Missense_Mutation_p.E236K|VEGFA_ENST00000518689.1_Missense_Mutation_p.E56K|VEGFA_ENST00000523125.1_Missense_Mutation_p.E56K|VEGFA_ENST00000413642.3_Missense_Mutation_p.E236K|VEGFA_ENST00000523950.1_Missense_Mutation_p.E56K|VEGFA_ENST00000523873.1_Missense_Mutation_p.E56K|VEGFA_ENST00000372077.4_Missense_Mutation_p.E56K|VEGFA_ENST00000482630.2_Missense_Mutation_p.E236K|VEGFA_ENST00000457104.2_Missense_Mutation_p.E56K|VEGFA_ENST00000230480.6_Missense_Mutation_p.E28K	NM_001025366.2|NM_001025367.2|NM_001025368.2|NM_001025369.2|NM_001033756.2|NM_001171623.1|NM_001171624.1|NM_001171625.1|NM_001171626.1|NM_001171627.1|NM_001171629.1|NM_003376.5	NP_001020537.2|NP_001020538.2|NP_001020539|NP_001020540.2|NP_001028928.1|NP_001165094.1|NP_001165095.1|NP_001165096.1|NP_001165097.1|NP_001165098.1|NP_001165100.1|NP_003367.4	P15692	VEGFA_HUMAN	vascular endothelial growth factor A	56					basophil chemotaxis|cellular response to hypoxia|induction of positive chemotaxis|platelet activation|platelet degranulation|platelet-derived growth factor receptor signaling pathway|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of cell adhesion|positive regulation of cell division|positive regulation of endothelial cell proliferation|positive regulation of leukocyte migration|positive regulation of mast cell chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|positive regulation of vascular permeability|regulation of cell shape|vascular endothelial growth factor receptor signaling pathway|vasculogenesis	cell surface|extracellular space|membrane|platelet alpha granule lumen	cell surface binding|chemoattractant activity|cytokine activity|fibronectin binding|growth factor activity|heparin binding|platelet-derived growth factor receptor binding|protein heterodimerization activity|protein homodimerization activity|vascular endothelial growth factor receptor 1 binding|vascular endothelial growth factor receptor 2 binding|vascular endothelial growth factor receptor binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|prostate(1)	9	all_cancers(18;5.46e-07)|all_epithelial(2;5.96e-08)|Lung NSC(15;0.000157)|all_lung(25;0.000486)|Hepatocellular(11;0.00309)		all cancers(41;0.000413)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0742)|OV - Ovarian serous cystadenocarcinoma(102;0.196)		Atorvastatin(DB01076)|Bevacizumab(DB00112)|Carvedilol(DB01136)|Ginkgo biloba(DB01381)|Gliclazide(DB01120)|Minocycline(DB01017)|Ranibizumab(DB01270)|Simvastatin(DB00641)	CCATCCAATCGAGACCCTGGT	0.547000													12	58					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158582732	158582732	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:158582732C>G	ENST00000368147.4	-	51	7189	c.7009G>C	c.(7009-7011)Gag>Cag	p.E2337Q		NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)		EF-hand 2.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					GTATAGTCCTCCAGTGAGACA	0.478000													8	39					0	0	1	0	0
POLA1	5422	broad.mit.edu	37	X	24766501	24766501	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:24766501G>C	ENST00000379068.3	+	25	2808	c.2765G>C	c.(2764-2766)cGg>cCg	p.R922P	POLA1_ENST00000379059.3_Missense_Mutation_p.R916P			P09884	DPOLA_HUMAN	polymerase (DNA directed), alpha 1, catalytic subunit	916					cell proliferation|DNA replication checkpoint|DNA replication, synthesis of RNA primer|DNA-dependent DNA replication initiation|double-strand break repair via nonhomologous end joining|interspecies interaction between organisms|lagging strand elongation|leading strand elongation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|cytoplasm|nuclear envelope|nuclear matrix|nucleolus|nucleoplasm	chromatin binding|DNA-directed DNA polymerase activity|metal ion binding|nucleoside binding	p.R916Q(1)		breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|ovary(2)|skin(2)	11					Clofarabine(DB00631)|Fludarabine(DB01073)	AGAGAGATCCGGAAACTGGTA	0.398000													4	70					0	0	1	0	0
KIF21B	23046	broad.mit.edu	37	1	200971448	200971448	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:200971448C>T	ENST00000332129.2	-	9	1559	c.1243G>A	c.(1243-1245)Gag>Aag	p.E415K	KIF21B_ENST00000461742.2_Missense_Mutation_p.E415K|KIF21B_ENST00000422435.2_Missense_Mutation_p.E415K|KIF21B_ENST00000360529.5_Missense_Mutation_p.E415K	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	415					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						CTATAGCCCTCAGCGCCATCC	0.607000													23	102					0	0	1	0	0
SNAI2	6591	broad.mit.edu	37	8	49832453	49832453	+	Splice_Site	SNP	A	A	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr8:49832453A>T	ENST00000396822.1	-	3	983		c.e3+1		SNAI2_ENST00000020945.1_Splice_Site			O43623	SNAI2_HUMAN	snail family zinc finger 2						canonical Wnt receptor signaling pathway|ectoderm and mesoderm interaction|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(2)|prostate(1)	18		all_cancers(86;0.0368)|all_epithelial(80;0.000624)|Lung NSC(129;0.0019)|all_lung(136;0.00502)				TTTTTCTCTTACCCGTGTGAG	0.453000													32	62					0	0	1	0	0
RFC4	5984	broad.mit.edu	37	3	186508143	186508143	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:186508143G>C	ENST00000392481.2	-	9	1135	c.854C>G	c.(853-855)tCt>tGt	p.S285C	RFC4_ENST00000433496.1_Intron|RFC4_ENST00000296273.2_Missense_Mutation_p.S285C	NM_181573.2	NP_853551.1	P35249	RFC4_HUMAN	replication factor C (activator 1) 4, 37kDa	285					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|phosphatidylinositol-mediated signaling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			breast(3)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26	all_cancers(143;2.92e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)	GBM - Glioblastoma multiforme(93;0.0739)		TTTGTCAAAAGAGCCACTCTG	0.363000													27	50					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37027964	37027964	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:37027964G>C	ENST00000358047.3	+	1	1533	c.1481G>C	c.(1480-1482)gGa>gCa	p.G494A		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	494										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						CCCGACACTGGAGTGTCCCAT	0.627000													20	98					0	0	1	0	0
MICAL1	64780	broad.mit.edu	37	6	109770638	109770638	+	Missense_Mutation	SNP	T	T	C	rs146727348	byFrequency	TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:109770638T>C	ENST00000368952.4	-	11	1828	c.1538A>G	c.(1537-1539)aAc>aGc	p.N513S	MICAL1_ENST00000358577.3_Missense_Mutation_p.N408S|MICAL1_ENST00000358807.3_Missense_Mutation_p.N494S			Q8TDZ2	MICA1_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 1	494	CH.				cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|liver(1)|lung(7)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	40		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)		CTTGTCGTTGTTCCTCTGCAC	0.597000													20	46					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11787043	11787043	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr17:11787043G>T	ENST00000262442.4	+	56	11015	c.10947G>T	c.(10945-10947)caG>caT	p.Q3649H	DNAH9_ENST00000396001.2_3'UTR|DNAH9_ENST00000608377.1_5'UTR|DNAH9_ENST00000454412.2_Missense_Mutation_p.Q3649H	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9		AAA 5 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TCACCAAGCAGACTGCTGCCG	0.507000													4	46					0.150653	0.15144	1	1	0
PRSS35	167681	broad.mit.edu	37	6	84233807	84233807	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:84233807G>C	ENST00000536636.1	+	3	992	c.647G>C	c.(646-648)aGa>aCa	p.R216T	PRSS35_ENST00000369700.3_Missense_Mutation_p.R216T	NM_001170423.1	NP_001163894.1	Q8N3Z0	PRS35_HUMAN	protease, serine, 35	216	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|endometrium(2)|large_intestine(12)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	32		all_cancers(76;0.000113)|Acute lymphoblastic leukemia(125;1.09e-08)|all_hematologic(105;3.12e-05)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0768)		GGTGACCAAAGAGAGGGTACC	0.517000													6	29					0	0	1	0	0
ANKAR	150709	broad.mit.edu	37	2	190541383	190541383	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:190541383C>T	ENST00000520309.1	+	2	255	c.167C>T	c.(166-168)tCt>tTt	p.S56F	ANKAR_ENST00000461516.1_Intron|ANKAR_ENST00000313581.4_Missense_Mutation_p.S56F|ANKAR_ENST00000438402.2_Missense_Mutation_p.S56F|ANKAR_ENST00000281412.6_5'UTR|ANKAR_ENST00000431575.2_5'UTR	NM_144708.3	NP_653309.3	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	56						integral to membrane	binding			breast(3)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(16)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(2)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			AGCTGGTTGTCTGCCAAAGAG	0.403000													16	78					0	0	1	0	0
ST6GAL1	6480	broad.mit.edu	37	3	186760673	186760673	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:186760673A>T	ENST00000169298.3	+	4	856	c.182A>T	c.(181-183)cAg>cTg	p.Q61L	ST6GAL1_ENST00000448044.1_Missense_Mutation_p.Q61L|ST6GAL1_ENST00000457772.2_Intron	NM_173216.2	NP_775323.1	P15907	SIAT1_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 1	61					humoral immune response|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	7	all_cancers(143;2.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;8.53e-19)	GBM - Glioblastoma multiforme(93;0.0939)		TCTGATTCCCAGTCTGTATCC	0.532000													14	78					0	0	1	0	0
LIPE	3991	broad.mit.edu	37	19	42907083	42907083	+	Silent	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:42907083C>G	ENST00000244289.4	-	9	2919	c.2643G>C	c.(2641-2643)ctG>ctC	p.L881L	LIPE-AS1_ENST00000597203.1_RNA|LIPE-AS1_ENST00000593491.2_RNA|LIPE-AS1_ENST00000594624.2_RNA|LIPE-AS1_ENST00000599276.1_RNA	NM_005357.2	NP_005348.2	Q05469	LIPS_HUMAN	lipase, hormone-sensitive	881					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			breast(2)|endometrium(4)|kidney(7)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	32		Prostate(69;0.00682)				AGTTTCCCCTCAGGCTCAAGT	0.612000													11	49					0	0	1	0	0
GDPD2	54857	broad.mit.edu	37	X	69649412	69649412	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:69649412C>A	ENST00000453994.2	+	11	1367	c.1006C>A	c.(1006-1008)Cca>Aca	p.P336T	GDPD2_ENST00000538649.1_Missense_Mutation_p.P257T|GDPD2_ENST00000536730.1_Missense_Mutation_p.P257T|GDPD2_ENST00000374382.3_Missense_Mutation_p.P336T|GDPD2_ENST00000472623.1_3'UTR	NM_001171192.1	NP_001164663.1	Q9HCC8	GDPD2_HUMAN	glycerophosphodiester phosphodiesterase domain containing 2	336	GDPD.				glycerol metabolic process|lipid metabolic process	cytoplasm|cytoskeleton|integral to membrane|plasma membrane	glycerophosphodiester phosphodiesterase activity|glycerophosphoinositol inositolphosphodiesterase activity|metal ion binding			NS(1)|breast(1)|cervix(1)|endometrium(6)|large_intestine(8)|lung(3)|ovary(2)	22	Renal(35;0.156)					TCAGACGGTACCAGCATTAGA	0.512000													4	38					0.00024832	0.000257686	1	1	0
PRDM4	11108	broad.mit.edu	37	12	108145474	108145474	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:108145474C>G	ENST00000228437.5	-	5	1303	c.844G>C	c.(844-846)Gac>Cac	p.D282H	RP11-864J10.4_ENST00000546714.1_RNA	NM_012406.3	NP_036538.3	Q9UKN5	PRDM4_HUMAN	PR domain containing 4	282					cell proliferation|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			biliary_tract(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|prostate(2)|skin(2)|urinary_tract(1)	20						AGGGCACTGTCAGACATGCCA	0.537000													15	26					0	0	1	0	0
TIAL1	7073	broad.mit.edu	37	10	121338340	121338340	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr10:121338340C>A	ENST00000369092.4	-	8	1393	c.85G>T	c.(85-87)Gaa>Taa	p.E29*	TIAL1_ENST00000369093.2_Nonsense_Mutation_p.E169*|TIAL1_ENST00000436547.2_Nonsense_Mutation_p.E152*			Q01085	TIAR_HUMAN	TIA1 cytotoxic granule-associated RNA binding protein-like 1	152	RRM 1.				apoptosis|defense response|induction of apoptosis|regulation of transcription from RNA polymerase II promoter	lysosome|nucleus|stress granule	nucleotide binding|RNA binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|liver(1)|lung(3)|ovary(1)	13		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.00239)|BRCA - Breast invasive adenocarcinoma(275;0.0932)		ATCGCATTTTCTGCATCCTAT	0.423000													15	30					8.60227e-14	9.38164e-14	1	1	0
TENM1	10178	broad.mit.edu	37	X	123680846	123680846	+	Silent	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:123680846G>C	ENST00000422452.2	-	15	2592	c.2529C>G	c.(2527-2529)ctC>ctG	p.L843L	TENM1_ENST00000371130.3_Silent_p.L843L	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		TTTGCTGAATGAGGTCAAGAG	0.438000													15	59					0	0	1	0	0
FOXQ1	94234	broad.mit.edu	37	6	1313480	1313480	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:1313480C>G	ENST00000296839.2	+	1	806	c.541C>G	c.(541-543)Ctg>Gtg	p.L181V		NM_033260.3	NP_150285.3	Q9C009	FOXQ1_HUMAN	forkhead box Q1	181					DNA fragmentation involved in apoptotic nuclear change|embryo development|hair follicle morphogenesis|pattern specification process|positive regulation of caspase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	caspase regulator activity|DNA bending activity|double-stranded DNA binding|estrogen receptor binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin conjugating enzyme binding			lung(1)|urinary_tract(1)	2	Ovarian(93;0.0733)	Breast(5;0.052)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.0954)|BRCA - Breast invasive adenocarcinoma(62;0.18)		CGTCAAGGTGCTGCGCGACCC	0.642000													10	34					0	0	1	0	0
KIR3DL1	3811	broad.mit.edu	37	19	55341591	55341591	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:55341591C>T	ENST00000391728.4	+	9	1229	c.1196C>T	c.(1195-1197)gCa>gTa	p.A399V	KIR3DL1_ENST00000326542.7_Missense_Mutation_p.A382V|KIR3DL1_ENST00000358178.4_Missense_Mutation_p.A304V|KIR3DL1_ENST00000402254.2_Intron|KIR3DL1_ENST00000538269.1_Missense_Mutation_p.A399V|KIR3DL1_ENST00000541392.1_Missense_Mutation_p.A382V	NM_013289.2	NP_037421.2			killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1											breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	11				GBM - Glioblastoma multiforme(193;0.0192)		GTGACATACGCACAGTTGGAT	0.517000													6	229					0	0	1	0	0
EPHA8	2046	broad.mit.edu	37	1	22924263	22924263	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:22924263G>A	ENST00000166244.3	+	11	2097	c.2025G>A	c.(2023-2025)gaG>gaA	p.E675E		NM_020526.3	NP_065387.1	P29322	EPHA8_HUMAN	EPH receptor A8	675	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(6)|lung(22)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		GCTACACGGAGAGACAGAGGC	0.652000													30	39					0	0	1	0	0
KDM2A	22992	broad.mit.edu	37	11	67022358	67022358	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:67022358G>C	ENST00000529006.2	+	21	3767	c.3321G>C	c.(3319-3321)ttG>ttC	p.L1107F	KDM2A_ENST00000308783.5_Missense_Mutation_p.L565F|KDM2A_ENST00000526258.1_3'UTR|KDM2A_ENST00000398645.2_3'UTR|KDM2A_ENST00000530342.1_Missense_Mutation_p.L668F	NM_012308.2	NP_036440.1	Q9Y2K7	KDM2A_HUMAN	lysine (K)-specific demethylase 2A	1107					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(15)|ovary(5)|skin(1)|urinary_tract(2)	36						GCAATAAATTGACAGACCAGA	0.488000													4	20					0	0	1	0	0
STRADA	92335	broad.mit.edu	37	17	61790876	61790876	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr17:61790876C>G	ENST00000245865.5	-	5	273	c.64G>C	c.(64-66)Gag>Cag	p.E22Q	STRADA_ENST00000392950.4_Missense_Mutation_p.E43Q|STRADA_ENST00000582137.1_Missense_Mutation_p.E51Q|STRADA_ENST00000580039.1_5'UTR|STRADA_ENST00000375840.4_Missense_Mutation_p.E22Q|STRADA_ENST00000579340.1_Missense_Mutation_p.E22Q|STRADA_ENST00000336174.6_Missense_Mutation_p.E80Q|STRADA_ENST00000447001.3_Missense_Mutation_p.E36Q|RP11-51F16.8_ENST00000580553.1_3'UTR			Q7RTN6	STRAA_HUMAN	STE20-related kinase adaptor alpha	80					activation of protein kinase activity|cell cycle arrest|insulin receptor signaling pathway|protein export from nucleus|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|kinase binding|protein kinase activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|liver(1)|lung(2)|ovary(1)|prostate(2)	13						ATCAGGTCCTCAAATCCTTTG	0.388000													22	95					0	0	1	0	0
ALG12	79087	broad.mit.edu	37	22	50307276	50307276	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr22:50307276G>A	ENST00000330817.6	-	2	411	c.138C>T	c.(136-138)ctC>ctT	p.L46L		NM_024105.3	NP_077010.1	Q9BV10	ALG12_HUMAN	ALG12, alpha-1,6-mannosyltransferase						dolichol-linked oligosaccharide biosynthetic process|GPI anchor biosynthetic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	integral to membrane|intrinsic to endoplasmic reticulum membrane				endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|prostate(3)	12		all_cancers(38;8.58e-10)|all_epithelial(38;1.15e-08)|all_lung(38;0.000109)|Lung NSC(38;0.0018)|Breast(42;0.00191)|Ovarian(80;0.0164)|Lung SC(80;0.164)		BRCA - Breast invasive adenocarcinoma(115;0.199)|LUAD - Lung adenocarcinoma(64;0.247)		GCCAGTGGTAGAGCAGGTCAT	0.612000													23	26					0	0	1	0	0
RILPL2	196383	broad.mit.edu	37	12	123907666	123907666	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:123907666C>T	ENST00000280571.8	-	3	826	c.530G>A	c.(529-531)aGa>aAa	p.R177K		NM_145058.1	NP_659495.1	Q969X0	RIPL2_HUMAN	Rab interacting lysosomal protein-like 2	177						cytosol|plasma membrane	identical protein binding			endometrium(1)|large_intestine(2)|lung(2)|skin(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000546)|Epithelial(86;0.00179)|all cancers(50;0.0168)		ATCTTTTTCTCTTCTTCCTCC	0.413000													10	49					0	0	1	0	0
CRTC1	23373	broad.mit.edu	37	19	18860678	18860678	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:18860678G>A	ENST00000338797.6	+	6	604	c.579G>A	c.(577-579)caG>caA	p.Q193Q	CRTC1_ENST00000601916.1_Silent_p.Q102Q|CRTC1_ENST00000321949.8_Silent_p.Q177Q|CRTC1_ENST00000594658.1_Silent_p.Q136Q	NM_001098482.1	NP_001091952.1	Q6UUV9	CRTC1_HUMAN	CREB regulated transcription coactivator 1	177					interspecies interaction between organisms|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	cAMP response element binding protein binding|protein binding		CRTC1/MAML2(516)	NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|skin(1)	19						ACGTGCACCAGAAAAGAGGTA	0.597000													12	26					0	0	1	0	0
ALMS1	7840	broad.mit.edu	37	2	73718610	73718610	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:73718610C>G	ENST00000264448.6	+	10	9632	c.9521C>G	c.(9520-9522)cCa>cGa	p.P3174R	ALMS1_ENST00000409009.1_Missense_Mutation_p.P3132R	NM_015120.4	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	3174					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						GAGGGGACCCCAGTATTTGCA	0.413000													3	35					0	0	1	0	0
ASCC3	10973	broad.mit.edu	37	6	101315833	101315833	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:101315833G>A	ENST00000369162.2	-	2	385	c.41C>T	c.(40-42)tCa>tTa	p.S14L	ASCC3_ENST00000522650.1_Missense_Mutation_p.S14L|ASCC3_ENST00000369143.2_Missense_Mutation_p.S14L	NM_006828.2	NP_006819.2	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit 3	14					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(20)|liver(1)|lung(36)|ovary(6)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	92		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		GGTGACATTTGAAAAGGAACG	0.348000													4	24					0	0	1	0	0
RIMS1	22999	broad.mit.edu	37	6	73000551	73000551	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:73000551C>A	ENST00000521978.1	+	25	3724	c.3724C>A	c.(3724-3726)Ccg>Acg	p.P1242T	RIMS1_ENST00000518273.1_Intron|RIMS1_ENST00000523963.1_Intron|RIMS1_ENST00000517960.1_Intron|RIMS1_ENST00000538414.1_Intron|RIMS1_ENST00000264839.7_Intron|RIMS1_ENST00000522291.1_Intron|RIMS1_ENST00000520567.1_Intron|RIMS1_ENST00000425662.2_Intron|RIMS1_ENST00000491071.2_Intron|RIMS1_ENST00000401910.3_Intron|RIMS1_ENST00000348717.5_Intron|RIMS1_ENST00000517827.1_Intron	NM_014989.5	NP_055804.2	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	1242					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(25)|liver(4)|lung(35)|ovary(9)|pancreas(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	102		all_epithelial(107;0.179)|all_hematologic(105;0.212)				GCCACCTTCTCCGCTTCTGAC	0.547000													3	17					0.00909568	0.00922986	1	1	0
IPO7	10527	broad.mit.edu	37	11	9466671	9466671	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:9466671G>T	ENST00000379719.3	+	25	3189	c.3047G>T	c.(3046-3048)gGa>gTa	p.G1016V		NM_006391.2	NP_006382.1	O95373	IPO7_HUMAN	importin 7	1016					interspecies interaction between organisms|signal transduction	Golgi apparatus|nuclear pore|soluble fraction	protein transporter activity|Ran GTPase binding|small GTPase regulator activity			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				all cancers(16;8.29e-09)|Epithelial(150;4.76e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0217)		AAGCATGGAGGATACAAATTC	0.378000													5	33					0.000274275	0.000284007	1	1	0
SCN10A	6336	broad.mit.edu	37	3	38739575	38739575	+	Silent	SNP	G	G	A	rs144598009		TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:38739575G>A	ENST00000449082.2	-	27	5135	c.5136C>T	c.(5134-5136)atC>atT	p.I1712I		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1712					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TGTTGACCATGATGAGGAAGG	0.522000													28	75					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126401010	126401010	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr4:126401010C>A	ENST00000394329.3	+	14	12601	c.12588C>A	c.(12586-12588)taC>taA	p.Y4196*	FAT4_ENST00000335110.5_Intron	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4196	EGF-like 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CTGGGAAATACTGTGAAAAAT	0.398000													7	20					7.48243e-07	7.86635e-07	1	1	0
PACSIN2	11252	broad.mit.edu	37	22	43284697	43284697	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr22:43284697G>A	ENST00000263246.3	-	5	762	c.561C>T	c.(559-561)ctC>ctT	p.L187L	PACSIN2_ENST00000407585.1_Silent_p.L187L|PACSIN2_ENST00000402229.1_Silent_p.L187L|PACSIN2_ENST00000403744.3_Silent_p.L187L|PACSIN2_ENST00000337959.4_Silent_p.L187L	NM_001184970.1	NP_001171899.1	Q9UNF0	PACN2_HUMAN	protein kinase C and casein kinase substrate in neurons 2	187					actin cytoskeleton organization|endocytosis	cytoplasmic membrane-bounded vesicle	transporter activity			NS(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(3)|prostate(2)|upper_aerodigestive_tract(1)	19		Glioma(61;0.222)				GCAATTTCTTGAGCTGTTCAG	0.463000													11	132					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130289661	130289661	+	Splice_Site	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:130289661G>A	ENST00000358511.6	+	6	2432		c.e6-1		COL6A6_ENST00000453409.2_Splice_Site	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6						axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						TCCTCTTTCAGAATGCAAGCG	0.388000													4	27					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14806702	14806702	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr9:14806702G>A	ENST00000380881.4	-	19	4049	c.3234C>T	c.(3232-3234)ctC>ctT	p.L1078L	FREM1_ENST00000422223.2_Silent_p.L1077L|FREM1_ENST00000380880.3_Silent_p.L1077L			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	1077					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		CCACAGAAGGGAGTATATTTT	0.428000													3	14					0	0	1	0	0
BEND6	221336	broad.mit.edu	37	6	56880015	56880015	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:56880015C>G	ENST00000370746.3	+	4	652	c.383C>G	c.(382-384)tCt>tGt	p.S128C	BEND6_ENST00000545789.1_Missense_Mutation_p.S30C|BEND6_ENST00000370750.2_3'UTR|BEND6_ENST00000484701.1_3'UTR	NM_152731.2	NP_689944.2	Q5SZJ8	BEND6_HUMAN	BEN domain containing 6	128										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)	17						ATGTCTACATCTGCATCCACC	0.458000													10	55					0	0	1	0	0
SPATA17	128153	broad.mit.edu	37	1	218036153	218036153	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:218036153C>G	ENST00000366933.4	+	10	1098	c.1043C>G	c.(1042-1044)tCa>tGa	p.S348*	SPATA17_ENST00000471021.1_3'UTR	NM_138796.2	NP_620151.1	Q96L03	SPT17_HUMAN	spermatogenesis associated 17	348						cytoplasm	calmodulin binding			endometrium(1)|kidney(1)|large_intestine(9)|lung(6)|pancreas(2)|prostate(1)|urinary_tract(1)	21				OV - Ovarian serous cystadenocarcinoma(81;0.0516)|all cancers(67;0.0891)|GBM - Glioblastoma multiforme(131;0.117)		GAGCTCTTCTCAAAGTATGGA	0.284000													76	176					0	0	1	0	0
IGJ	3512	broad.mit.edu	37	4	71522974	71522974	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr4:71522974G>A	ENST00000254801.4	-	3	392	c.223C>T	c.(223-225)Ccc>Tcc	p.P75S	ENAM_ENST00000472903.1_Intron|IGJ_ENST00000543780.1_Missense_Mutation_p.P91S	NM_144646.3	NP_653247.1	P01591	IGJ_HUMAN	immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides	75					immune response	extracellular region	antigen binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	7			Lung(101;0.235)			GGTGAGGTGGGATCAGAGATA	0.313000													6	24					0	0	1	0	0
EPHB6	2051	broad.mit.edu	37	7	142562357	142562357	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:142562357G>C	ENST00000392957.2	+	7	1586	c.799G>C	c.(799-801)Gag>Cag	p.E267Q	EPHB6_ENST00000442129.1_Missense_Mutation_p.E267Q|EPHB6_ENST00000411471.2_Intron	NM_004445.3	NP_004436.3	O15197	EPHB6_HUMAN	EPH receptor B6	267	Cys-rich.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					GGCTCATGCAGAGCCAGAGGA	0.682000													11	53					0	0	1	0	0
PLB1	151056	broad.mit.edu	37	2	28804960	28804960	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:28804960C>T	ENST00000327757.5	+	24	1636	c.1592C>T	c.(1591-1593)aCa>aTa	p.T531I	PLB1_ENST00000329020.6_Missense_Mutation_p.T219I|PLB1_ENST00000422425.2_Intron	NM_153021.4	NP_694566.4	Q6P1J6	PLB1_HUMAN	phospholipase B1	531	4 X 308-326 AA approximate repeats.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(31)|ovary(6)|prostate(1)|skin(7)|stomach(2)	69	Acute lymphoblastic leukemia(172;0.155)					CAGAACTTCACAGACAACATT	0.512000													6	47					0	0	1	0	0
KIF26B	55083	broad.mit.edu	37	1	245852042	245852042	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:245852042C>G	ENST00000366518.4	+	9	4718	c.4614C>G	c.(4612-4614)agC>agG	p.S1538R	KIF26B_ENST00000407071.2_Missense_Mutation_p.S1919R			Q2KJY2	KI26B_HUMAN	kinesin family member 26B	1919					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			ACTCCACGAGCGAGAACAGCA	0.701000													3	26					0	0	1	0	0
MOXD1	26002	broad.mit.edu	37	6	132644006	132644006	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:132644006G>C	ENST00000367963.3	-	8	1235	c.1117C>G	c.(1117-1119)Ctg>Gtg	p.L373V	MOXD1_ENST00000336749.3_Missense_Mutation_p.L305V|MOXD1_ENST00000489128.1_5'UTR	NM_015529.2	NP_056344.2	Q6UVY6	MOXD1_HUMAN	monooxygenase, DBH-like 1	373					catecholamine metabolic process	endoplasmic reticulum membrane|integral to membrane	copper ion binding|dopamine beta-monooxygenase activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|prostate(3)|skin(1)	37	Breast(56;0.0495)			OV - Ovarian serous cystadenocarcinoma(155;0.0132)|GBM - Glioblastoma multiforme(226;0.0191)		TCGGCTTCCAGAGCCTACAGG	0.473000													5	10					0	0	1	0	0
CCDC132	55610	broad.mit.edu	37	7	92983073	92983073	+	Splice_Site	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:92983073G>A	ENST00000544910.1	+	27	2715	c.2495G>A	c.(2494-2496)gGa>gAa	p.G832E	CCDC132_ENST00000535481.1_Splice_Site_p.G582E|CCDC132_ENST00000541136.1_3'UTR|CCDC132_ENST00000305866.5_Splice_Site_p.G862E|CCDC132_ENST00000474412.1_3'UTR	NM_001257998.1	NP_001244927.1	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132	862										endometrium(1)|large_intestine(2)|lung(5)	8	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			ATTGTAGAAGGGTAAGTTTTT	0.313000													14	49					0	0	1	0	0
ZNF534	147658	broad.mit.edu	37	19	52937307	52937307	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:52937307G>C	ENST00000332323.6	+	2	176	c.115G>C	c.(115-117)Gag>Cag	p.E39Q	ZNF534_ENST00000301085.4_Missense_Mutation_p.E39Q|ZNF534_ENST00000432303.2_Missense_Mutation_p.E39Q|ZNF534_ENST00000433050.1_Missense_Mutation_p.E39Q	NM_001143939.1	NP_001137411.1	Q76KX8	ZN534_HUMAN	zinc finger protein 534	39	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|lung(1)|prostate(1)|skin(1)	4						CGTGATGTTAGAGAACTACAG	0.483000													14	100					0	0	1	0	0
LRRC37A3	374819	broad.mit.edu	37	17	62892305	62892305	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr17:62892305G>A	ENST00000584306.1	-	3	1601	c.1071C>T	c.(1069-1071)atC>atT	p.I357I	LRRC37A3_ENST00000400877.3_Intron|RP11-927P21.1_ENST00000584131.1_RNA|RP11-927P21.1_ENST00000584959.1_RNA|RP11-927P21.1_ENST00000577938.1_RNA|LRRC37A3_ENST00000339474.5_Intron|LRRC37A3_ENST00000319651.5_Silent_p.I357I	NM_199340.2	NP_955372.2	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	357						integral to membrane				NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|liver(1)|lung(10)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						GCTGCTCACTGATGGAAAGTT	0.547000													39	127					0	0	1	0	0
PDGFC	56034	broad.mit.edu	37	4	157891978	157891978	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr4:157891978C>T	ENST00000502773.1	-	1	568	c.78G>A	c.(76-78)ctG>ctA	p.L26L	PDGFC_ENST00000541126.1_5'UTR|PDGFC_ENST00000422544.2_Silent_p.L26L	NM_016205.2	NP_057289.1	Q9NRA1	PDGFC_HUMAN	platelet derived growth factor C	26					central nervous system development|platelet-derived growth factor receptor signaling pathway|positive regulation of cell division|positive regulation of DNA replication|positive regulation of fibroblast proliferation|vascular endothelial growth factor receptor signaling pathway	endoplasmic reticulum lumen|extracellular space|Golgi membrane|nucleus	cell surface binding|growth factor activity|platelet-derived growth factor receptor binding|protein homodimerization activity			central_nervous_system(1)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.08)|Kidney(143;0.0977)|COAD - Colon adenocarcinoma(41;0.212)		ATTTACTACTCAGGTTGGATT	0.547000											OREG0016375	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	37					0	0	1	0	0
ZNF639	51193	broad.mit.edu	37	3	179046084	179046084	+	Translation_Start_Site	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:179046084G>C	ENST00000326361.3	+	4	448	c.3G>C	c.(1-3)atG>atC	p.M1I	ZNF639_ENST00000484866.1_Start_Codon_SNP_p.M1I|ZNF639_ENST00000496856.1_Start_Codon_SNP_p.M1I	NM_016331.1	NP_057415.1	Q9UID6	ZN639_HUMAN	zinc finger protein 639	1					initiation of viral infection|negative regulation by host of viral transcription|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of cell growth|positive regulation of transcription, DNA-dependent	nucleus	protein self-association|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(10)|urinary_tract(1)	16	all_cancers(143;7.9e-17)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			GAAAAGATATGAATGAGTATC	0.284000													37	27					0	0	1	0	0
FAM214A	56204	broad.mit.edu	37	15	52903803	52903803	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr15:52903803C>G	ENST00000261844.7	-	4	525	c.373G>C	c.(373-375)Gaa>Caa	p.E125Q	FAM214A_ENST00000546305.2_Missense_Mutation_p.E132Q	NM_019600.2	NP_062546.2	Q32MH5	K1370_HUMAN	family with sequence similarity 214, member A	125																	ATCCATCTTTCTAATAATAAT	0.388000													11	60					0	0	1	0	0
COX11	1353	broad.mit.edu	37	17	53045689	53045689	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr17:53045689G>A	ENST00000299335.3	-	1	457	c.319C>T	c.(319-321)Ctg>Ttg	p.L107L	COX11_ENST00000571584.1_Silent_p.L107L	NM_004375.3	NP_004366.1	Q9Y6N1	COX11_HUMAN	cytochrome c oxidase assembly homolog 11 (yeast)	107					respiratory chain complex IV assembly|respiratory gaseous exchange	integral to membrane|mitochondrial inner membrane	copper ion binding|cytochrome-c oxidase activity|electron carrier activity			endometrium(1)|kidney(1)|large_intestine(1)|liver(2)|lung(2)|ovary(1)|prostate(1)	9						GACGCCCCCAGCATGCCCACG	0.687000													17	23					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	145075715	145075715	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:145075715C>T	ENST00000369359.4	-	1	186	c.148G>A	c.(148-150)Gaa>Aaa	p.E50K	PDE4DIP_ENST00000530740.1_Missense_Mutation_p.E50K|PDE4DIP_ENST00000369348.3_Missense_Mutation_p.E50K|PDE4DIP_ENST00000369345.4_Missense_Mutation_p.E50K			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	0					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CGCCGTCTTTCCCGGCTCGGG	0.721000			T	PDGFRB	MPD								4	86					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20963831	20963831	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr16:20963831C>A	ENST00000261383.3	-	56	11111	c.11112G>T	c.(11110-11112)agG>agT	p.R3704S	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3704	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		ACATACTAATCCTCAGGTCAG	0.468000													12	16					1.5842e-08	1.68201e-08	1	1	0
ZCCHC10	54819	broad.mit.edu	37	5	132335832	132335832	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr5:132335832C>G	ENST00000324170.3	-	3	303	c.237G>C	c.(235-237)aaG>aaC	p.K79N	ZCCHC10_ENST00000509008.1_Missense_Mutation_p.E89Q|ZCCHC10_ENST00000355372.2_Missense_Mutation_p.K101N|ZCCHC10_ENST00000513541.1_Missense_Mutation_p.E111Q|ZCCHC10_ENST00000508080.1_5'UTR|ZCCHC10_ENST00000513848.1_Intron|ZCCHC10_ENST00000509437.1_Missense_Mutation_p.K101N	NM_017665.1	NP_060135.1	Q8TBK6	ZCH10_HUMAN	zinc finger, CCHC domain containing 10	101							nucleic acid binding|zinc ion binding	p.K79N(1)		skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ACCTTTTTTTCTTGGCCTTTC	0.378000													16	32					0	0	1	0	0
NFATC3	4775	broad.mit.edu	37	16	68225423	68225423	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr16:68225423C>T	ENST00000349223.5	+	9	3075	c.2851C>T	c.(2851-2853)Cct>Tct	p.P951S	NFATC3_ENST00000575270.1_Missense_Mutation_p.P951S|NFATC3_ENST00000535127.2_3'UTR|NFATC3_ENST00000346183.3_Missense_Mutation_p.P951S|NFATC3_ENST00000329524.4_Missense_Mutation_p.P951S	NM_173163.2	NP_775186.1	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	951					inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	44		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		TCAGCCTATGCCTTACCAATC	0.542000													12	31					0	0	1	0	0
AURKC	6795	broad.mit.edu	37	19	57746784	57746784	+	Nonstop_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:57746784G>C	ENST00000302804.7	+	7	1115	c.929G>C	c.(928-930)tGa>tCa	p.*310S	AURKC_ENST00000415300.2_Nonstop_Mutation_p.*291S|AURKC_ENST00000599062.1_Nonstop_Mutation_p.*307S|AURKC_ENST00000598785.1_Nonstop_Mutation_p.*276S|AURKC_ENST00000448930.1_Nonstop_Mutation_p.*276S	NM_001015878.1	NP_001015878.1	Q9UQB9	AURKC_HUMAN	aurora kinase C	0					cell cycle|cytokinesis	condensed chromosome|cytoplasm|midbody|spindle midzone	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(1)|large_intestine(9)|lung(9)|ovary(3)|prostate(1)|stomach(1)	25		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0122)		ATGGCTTCCTGAGCCCTGTCT	0.552000													42	56					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168106680	168106680	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:168106680C>G	ENST00000409195.1	+	9	8867	c.8778C>G	c.(8776-8778)ttC>ttG	p.F2926L	XIRP2_ENST00000409273.1_Missense_Mutation_p.F2704L|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.F2926L|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409756.2_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	2751					actin cytoskeleton organization	cell junction	actin binding	p.F2926F(1)		NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						ACAAATCTTTCTTTTCCTCTG	0.378000													19	60					0	0	1	0	0
HEATR5A	25938	broad.mit.edu	37	14	31782177	31782177	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr14:31782177C>T	ENST00000543095.2	-	28	4622	c.4438G>A	c.(4438-4440)Gaa>Aaa	p.E1480K	HEATR5A_ENST00000439348.1_Missense_Mutation_p.E1474K|HEATR5A_ENST00000439727.1_Missense_Mutation_p.E1187K|HEATR5A_ENST00000389961.3_Missense_Mutation_p.E1474K	NM_015473.3	NP_056288.2	Q86XA9	HTR5A_HUMAN	HEAT repeat containing 5A	1474							binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)	26	Hepatocellular(127;0.0877)|Breast(36;0.137)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.0797)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0059)		TCCTTACCTTCAGCAGGAAGT	0.388000													3	16					0	0	1	0	0
PIP5K1A	8394	broad.mit.edu	37	1	151214973	151214973	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:151214973G>A	ENST00000409426.1	+	13	1979	c.1534G>A	c.(1534-1536)Gag>Aag	p.E512K	PIP5K1A_ENST00000414290.2_Intron|PIP5K1A_ENST00000441902.2_Missense_Mutation_p.E484K|PIP5K1A_ENST00000368890.4_Missense_Mutation_p.E462K|PIP5K1A_ENST00000368888.4_Missense_Mutation_p.E524K			Q99755	PI51A_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type I, alpha	524					phospholipid biosynthetic process|signal transduction	endomembrane system|Golgi stack|lamellipodium|nuclear speck	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|kinase binding			breast(1)|central_nervous_system(1)|ovary(1)|skin(1)|stomach(1)	5	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.181)			GGAAATCAGTGAGGGCTCGCC	0.453000													53	149					0	0	1	0	0
LRRC37A4P	55073	broad.mit.edu	37	17	43587576	43587576	+	RNA	SNP	A	A	G	rs145439557	by1000genomes	TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr17:43587576A>G	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							tctgaaaagaaaagaaaaaaa	0.428000													3	12					0	0	1	0	0
FN1	2335	broad.mit.edu	37	2	216279649	216279649	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:216279649C>G	ENST00000354785.4	-	13	2221	c.1852G>C	c.(1852-1854)Gag>Cag	p.E618Q	FN1_ENST00000432072.2_Missense_Mutation_p.E618Q|FN1_ENST00000357009.2_Missense_Mutation_p.E618Q|FN1_ENST00000426059.1_Missense_Mutation_p.E618Q|FN1_ENST00000359671.1_Missense_Mutation_p.E618Q|FN1_ENST00000346544.3_Missense_Mutation_p.E618Q|FN1_ENST00000345488.5_Missense_Mutation_p.E618Q|FN1_ENST00000323926.6_Missense_Mutation_p.E618Q|FN1_ENST00000357867.4_Missense_Mutation_p.E618Q|FN1_ENST00000446046.1_Missense_Mutation_p.E618Q|FN1_ENST00000443816.1_Missense_Mutation_p.E618Q|FN1_ENST00000421182.1_Missense_Mutation_p.E618Q|FN1_ENST00000356005.4_Missense_Mutation_p.E618Q|FN1_ENST00000336916.4_Missense_Mutation_p.E618Q			P02751	FINC_HUMAN	fibronectin 1	618	Fibronectin type-III 1.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding		FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTCGGAGTCTCAGTGATAAAT	0.433000													10	39					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14806697	14806697	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr9:14806697G>T	ENST00000380881.4	-	19	4054	c.3239C>A	c.(3238-3240)tCt>tAt	p.S1080Y	FREM1_ENST00000422223.2_Missense_Mutation_p.S1079Y|FREM1_ENST00000380880.3_Missense_Mutation_p.S1079Y			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	1079					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		AAAACCCACAGAAGGGAGTAT	0.438000													3	14					0.004672	0.00476603	1	1	0
UNC5C	8633	broad.mit.edu	37	4	96171718	96171718	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr4:96171718G>C	ENST00000453304.1	-	5	1043	c.695C>G	c.(694-696)tCt>tGt	p.S232C	UNC5C_ENST00000506749.1_Missense_Mutation_p.S232C|UNC5C_ENST00000504962.1_Missense_Mutation_p.S232C	NM_003728.3	NP_003719.3	O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	232	Ig-like C2-type.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		TGCAGTATCAGAGAGTCGGGC	0.413000													58	94					0	0	1	0	0
RAB9BP1	9366	broad.mit.edu	37	5	104435325	104435325	+	RNA	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr5:104435325G>A	ENST00000522464.1	-	0	68				RP11-6N13.1_ENST00000503650.1_lincRNA																							AGATTTGGAAGTGGATGGACA	0.393000													11	21					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24922370	24922370	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr15:24922370G>T	ENST00000329468.2	+	1	1830	c.1356G>T	c.(1354-1356)gaG>gaT	p.E452D		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		AAATGGATGAGAAAATAGCAT	0.488000													8	81					0.00307968	0.00315839	1	1	0
RHOBTB1	9886	broad.mit.edu	37	10	62670660	62670660	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr10:62670660C>T	ENST00000337910.5	-	4	618	c.281G>A	c.(280-282)cGc>cAc	p.R94H	RHOBTB1_ENST00000357917.4_Missense_Mutation_p.R94H	NM_001242359.1|NM_014836.4	NP_001229288.1|NP_055651.1	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	94	Rho-like.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23	Prostate(12;0.0112)					ATATGCAAAGCGTCTGTCTTT	0.443000													5	19					0	0	1	0	0
PCDH9	5101	broad.mit.edu	37	13	66878835	66878835	+	Nonsense_Mutation	SNP	A	A	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr13:66878835A>C	ENST00000544246.1	-	5	4357	c.3666T>G	c.(3664-3666)taT>taG	p.Y1222*	PCDH9-AS1_ENST00000430861.1_RNA|PCDH9_ENST00000328454.5_Nonsense_Mutation_p.Y1188*|PCDH9_ENST00000377865.2_Nonsense_Mutation_p.Y1222*|PCDH9_ENST00000456367.1_Nonsense_Mutation_p.Y1188*	NM_203487.2	NP_982354.1	Q9HC56	PCDH9_HUMAN	protocadherin 9	1222					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(33)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	103		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		CTGCTTGCTTATAAGACTTCA	0.438000													5	38					0	0	1	0	0
EGFLAM	133584	broad.mit.edu	37	5	38338854	38338854	+	Missense_Mutation	SNP	G	G	A	rs145835462	byFrequency	TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr5:38338854G>A	ENST00000322350.5	+	3	608	c.262G>A	c.(262-264)Gtg>Atg	p.V88M	EGFLAM_ENST00000354891.3_Missense_Mutation_p.V88M	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	88	Fibronectin type-III 1.					cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					GTTGCACAGCGTGCCTCTCAG	0.557000													10	37					0	0	1	0	0
EPB41L2	2037	broad.mit.edu	37	6	131277156	131277156	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:131277156G>T	ENST00000337057.3	-	2	651	c.470C>A	c.(469-471)tCa>tAa	p.S157*	EPB41L2_ENST00000527659.1_Nonsense_Mutation_p.S157*|EPB41L2_ENST00000530481.1_Nonsense_Mutation_p.S157*|EPB41L2_ENST00000525193.1_Nonsense_Mutation_p.S157*|EPB41L2_ENST00000368128.2_Nonsense_Mutation_p.S157*|EPB41L2_ENST00000529208.1_Nonsense_Mutation_p.S157*|EPB41L2_ENST00000530148.1_Intron|EPB41L2_ENST00000525271.1_Nonsense_Mutation_p.S157*|EPB41L2_ENST00000528282.1_Nonsense_Mutation_p.S157*|EPB41L2_ENST00000445890.2_Nonsense_Mutation_p.S157*|EPB41L2_ENST00000527411.1_Nonsense_Mutation_p.S157*|EPB41L2_ENST00000392427.3_Nonsense_Mutation_p.S157*	NM_001431.3	NP_001422.1	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	157					cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(23)|prostate(1)|skin(2)	44	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		TTTGCTCACTGAGGGTTTTTC	0.403000													49	166					2.47907e-22	2.75039e-22	1	1	0
SREK1	140890	broad.mit.edu	37	5	65455156	65455156	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr5:65455156G>C	ENST00000334121.6	+	3	564	c.405G>C	c.(403-405)ttG>ttC	p.L135F	SREK1_ENST00000284041.3_3'UTR|SREK1_ENST00000380918.3_Missense_Mutation_p.L19F	NM_001077199.2|NM_001270492.1	NP_001070667.1|NP_001257421.1	Q8WXA9	SREK1_HUMAN	splicing regulatory glutamine/lysine-rich protein 1	19	RRM.				mRNA processing|RNA splicing	spliceosomal complex	nucleic acid binding|nucleotide binding|protein binding			breast(1)|kidney(3)|large_intestine(2)|lung(1)|pancreas(1)|prostate(1)	9						CAAATCCTTTGACTACTGTAA	0.438000													5	25					0	0	1	0	0
ZBTB32	27033	broad.mit.edu	37	19	36205943	36205943	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:36205943G>A	ENST00000392197.2	+	3	733	c.415G>A	c.(415-417)Gag>Aag	p.E139K	ZBTB32_ENST00000262630.3_Missense_Mutation_p.E139K			Q9Y2Y4	ZBT32_HUMAN	zinc finger and BTB domain containing 32	139					DNA repair|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleoplasm	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			large_intestine(5)|lung(1)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	14	all_lung(56;2.22e-07)|Lung NSC(56;3.47e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			AAGGAATCCTGAGAGAGAACT	0.547000													17	24					0	0	1	0	0
ZNF254	9534	broad.mit.edu	37	19	24310715	24310715	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:24310715C>T	ENST00000357002.4	+	4	2028	c.1913C>T	c.(1912-1914)gCc>gTc	p.A638V	ZNF254_ENST00000342944.6_Missense_Mutation_p.A553V	NM_001278661.1|NM_001278662.1|NM_001278664.1|NM_001278677.1|NM_001278678.1|NM_203282.2	NP_001265590.1|NP_001265591.1|NP_001265593.1|NP_001265606.1|NP_001265607.1|NP_975011.3	O75437	ZN254_HUMAN	zinc finger protein 254	638					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				TTTGGCAAAGCCTTTAATCGG	0.393000													13	101					0	0	1	0	0
ZFYVE28	57732	broad.mit.edu	37	4	2306843	2306843	+	Silent	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr4:2306843C>A	ENST00000290974.2	-	8	1563	c.1224G>T	c.(1222-1224)ggG>ggT	p.G408G	ZFYVE28_ENST00000511071.1_Silent_p.G378G|ZFYVE28_ENST00000515312.1_Silent_p.G338G|RP11-478C1.7_ENST00000510632.1_RNA	NM_020972.2	NP_066023.2	Q9HCC9	LST2_HUMAN	zinc finger, FYVE domain containing 28	408					negative regulation of epidermal growth factor receptor activity	cytosol|early endosome membrane	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(4)	31						CTTCTGCCGTCCCCTCCACGT	0.701000													18	40					4.96729e-08	5.25659e-08	1	1	0
PZP	5858	broad.mit.edu	37	12	9353018	9353018	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:9353018G>C	ENST00000261336.2	-	7	725	c.697C>G	c.(697-699)Cag>Gag	p.Q233E	PZP_ENST00000381997.2_Missense_Mutation_p.Q102E	NM_002864.2	NP_002855.2			pregnancy-zone protein											breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(21)|lung(46)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)	102						TTTGGCACCTGAACTTTGACC	0.318000													3	42					0	0	1	0	0
GPX7	2882	broad.mit.edu	37	1	53073984	53073984	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:53073984C>T	ENST00000361314.4	+	3	489	c.451C>T	c.(451-453)Cca>Tca	p.P151S		NM_015696.4	NP_056511.2	Q96SL4	GPX7_HUMAN	glutathione peroxidase 7	151					response to oxidative stress	extracellular region	glutathione peroxidase activity			breast(1)|kidney(1)|lung(4)|upper_aerodigestive_tract(1)	7					Glutathione(DB00143)	CCTAGTAGCCCCAGATGGAAA	0.562000													23	43					0	0	1	0	0
SULT1B1	27284	broad.mit.edu	37	4	70615496	70615496	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr4:70615496C>T	ENST00000310613.3	-	4	615	c.318G>A	c.(316-318)gtG>gtA	p.V106V		NM_014465.3	NP_055280.2	O43704	ST1B1_HUMAN	sulfotransferase family, cytosolic, 1B, member 1						3'-phosphoadenosine 5'-phosphosulfate metabolic process|cellular biogenic amine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|thyroid hormone metabolic process|xenobiotic metabolic process	cytosol				breast(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(14)|prostate(1)|upper_aerodigestive_tract(1)	24						GATGTGTTTTCACAATCCGGG	0.388000													15	45					0	0	1	0	0
TBC1D8B	54885	broad.mit.edu	37	X	106116801	106116801	+	Splice_Site	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:106116801C>G	ENST00000357242.5	+	21	3143	c.2969C>G	c.(2968-2970)tCt>tGt	p.S990C	TBC1D8B_ENST00000276175.3_Splice_Site_p.S984C	NM_017752.2	NP_060222.2	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	990						intracellular	calcium ion binding|Rab GTPase activator activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|liver(4)|lung(15)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						GTCTTCTAGTCTCAGTTTATT	0.328000													15	50					0	0	1	0	0
PHKA2	5256	broad.mit.edu	37	X	18943857	18943857	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:18943857G>C	ENST00000379942.4	-	15	2163	c.1498C>G	c.(1498-1500)Cga>Gga	p.R500G		NM_000292.2	NP_000283.1	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	500					glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			NS(1)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(12)|lung(23)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	61	Hepatocellular(33;0.183)					CCAATATGTCGATACGGTCGC	0.408000													5	175					0	0	1	0	0
PRKCD	5580	broad.mit.edu	37	3	53220213	53220213	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:53220213G>C	ENST00000394729.2	+	12	1445	c.1117G>C	c.(1117-1119)Gag>Cag	p.E373Q	PRKCD_ENST00000330452.3_Missense_Mutation_p.E373Q	NM_212539.1	NP_997704.1	Q05655	KPCD_HUMAN	protein kinase C, delta	373	Protein kinase.				activation of phospholipase C activity|cellular component disassembly involved in apoptosis|cellular senescence|interferon-gamma-mediated signaling pathway|intracellular signal transduction|mRNA metabolic process|negative regulation of insulin receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein binding|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of ceramide biosynthetic process|positive regulation of glucosylceramide catabolic process|positive regulation of protein dephosphorylation|positive regulation of sphingomyelin catabolic process|protein stabilization|regulation of receptor activity|termination of signal transduction	cytosol|endoplasmic reticulum|nucleoplasm	ATP binding|calcium-independent protein kinase C activity|enzyme activator activity|enzyme binding|insulin receptor substrate binding|metal ion binding|protein C-terminus binding			breast(1)|central_nervous_system(4)|endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Ovarian(412;0.0728)		OV - Ovarian serous cystadenocarcinoma(275;3.58e-08)|BRCA - Breast invasive adenocarcinoma(193;0.000142)|Kidney(197;0.00153)|KIRC - Kidney renal clear cell carcinoma(197;0.00173)		GGGCAGAGGAGAGTACTTTGC	0.607000													8	17					0	0	1	0	0
MARCO	8685	broad.mit.edu	37	2	119726835	119726835	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:119726835A>C	ENST00000327097.4	+	2	332	c.197A>C	c.(196-198)cAa>cCa	p.Q66P	MARCO_ENST00000541757.1_5'UTR	NM_006770.3	NP_006761.1	Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	66					cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(12)|lung(37)|ovary(4)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	70						CTGGTGGTCCAAGGTAAAGCA	0.607000													11	44					0	0	1	0	0
FAM71B	153745	broad.mit.edu	37	5	156593038	156593038	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr5:156593038C>G	ENST00000302938.4	-	1	237	c.142G>C	c.(142-144)Gag>Cag	p.E48Q		NM_130899.2	NP_570969.2	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	48						nucleus				NS(3)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(32)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AAATTACTCTCGAACATTGGT	0.453000													37	40					0	0	1	0	0
LHB	3972	broad.mit.edu	37	19	49519550	49519550	+	Silent	SNP	C	C	T	rs149579838	by1000genomes	TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:49519550C>T	ENST00000221421.2	-	3	200	c.201G>A	c.(199-201)gcG>gcA	p.A67A		NM_000894.2	NP_000885.1	P01229	LSHB_HUMAN	luteinizing hormone beta polypeptide	67					cell-cell signaling|cellular nitrogen compound metabolic process|male gonad development|peptide hormone processing|progesterone biosynthetic process|signal transduction	extracellular region|soluble fraction	hormone activity			cervix(1)|endometrium(1)|large_intestine(1)|lung(4)|prostate(1)	8		all_epithelial(76;9.62e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000371)|OV - Ovarian serous cystadenocarcinoma(262;0.000503)|GBM - Glioblastoma multiforme(486;0.00518)|Epithelial(262;0.0427)	Lutropin alfa(DB00044)|Menotropins(DB00032)	GCGGCAGGACCGCCTGCAGCA	0.677000													7	86					0	0	1	0	0
TIMM44	10469	broad.mit.edu	37	19	8000015	8000015	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:8000015C>G	ENST00000270538.3	-	4	596	c.328G>C	c.(328-330)Gaa>Caa	p.E110Q		NM_006351.3	NP_006342.2	O43615	TIM44_HUMAN	translocase of inner mitochondrial membrane 44 homolog (yeast)	110					protein targeting to mitochondrion	mitochondrial inner membrane presequence translocase complex|mitochondrial matrix	ATP binding|P-P-bond-hydrolysis-driven protein transmembrane transporter activity	p.E110Q(1)		NS(1)|endometrium(3)|kidney(3)|large_intestine(2)|liver(2)|lung(2)|ovary(2)|skin(1)|urinary_tract(1)	17						CGCACGGTTTCTGACTCGATG	0.552000													3	14					0	0	1	0	0
PFN2	5217	broad.mit.edu	37	3	149684286	149684286	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:149684286G>C	ENST00000239940.7	-	3	665	c.413C>G	c.(412-414)tCt>tGt	p.S138C	PFN2_ENST00000481275.1_Missense_Mutation_p.S89C|PFN2_ENST00000494827.1_Intron|PFN2_ENST00000475518.1_Missense_Mutation_p.S89C|PFN2_ENST00000497148.1_Missense_Mutation_p.S89C|PFN2_ENST00000498307.1_Missense_Mutation_p.S89C|PFN2_ENST00000423691.2_Intron|PFN2_ENST00000452853.2_Intron|PFN2_ENST00000489155.1_Missense_Mutation_p.S89C|PFN2_ENST00000481767.1_Intron|PFN2_ENST00000490975.1_Missense_Mutation_p.S123C			P35080	PROF2_HUMAN	profilin 2	138					actin cytoskeleton organization|regulation of actin polymerization or depolymerization	actin cytoskeleton|cytoplasm	actin binding|phosphatidylinositol-4,5-bisphosphate binding			large_intestine(1)|lung(4)|ovary(1)|prostate(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			CTAGAACCCAGAGTCTCTCAA	0.388000													46	255					0	0	1	0	0
PHKA2	5256	broad.mit.edu	37	X	18918793	18918793	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:18918793C>T	ENST00000379942.4	-	28	3717	c.3052G>A	c.(3052-3054)Gaa>Aaa	p.E1018K		NM_000292.2	NP_000283.1	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	1018					glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			NS(1)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(12)|lung(23)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	61	Hepatocellular(33;0.183)					GTCACCTGTTCATCAGCACTA	0.468000													11	42					0	0	1	0	0
NUMA1	4926	broad.mit.edu	37	11	71729512	71729512	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:71729512G>A	ENST00000393695.3	-	11	1121	c.790C>T	c.(790-792)Ctg>Ttg	p.L264L	RP11-849H4.4_ENST00000502284.1_RNA|NUMA1_ENST00000351960.6_Silent_p.L264L|NUMA1_ENST00000358965.6_Silent_p.L264L	NM_006185.2	NP_006176.2	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	264					G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(12)|lung(20)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	65						TTCTCATTCAGCAGGGCTAGG	0.582000			T	RARA	APL								5	22					0	0	1	0	0
CHD5	26038	broad.mit.edu	37	1	6186675	6186675	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:6186675G>A	ENST00000262450.3	-	26	4134	c.4035C>T	c.(4033-4035)atC>atT	p.I1345I	CHD5_ENST00000378021.1_Silent_p.I202I	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1345					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		CCTGCTTGCGGATGCGCTTGC	0.667000													22	29					0	0	1	0	0
RAB1A	5861	broad.mit.edu	37	2	65331928	65331928	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:65331928G>C	ENST00000409784.3	-	2	226	c.36C>G	c.(34-36)ttC>ttG	p.F12L	RAB1A_ENST00000409751.1_Missense_Mutation_p.F12L|RAB1A_ENST00000356214.7_Missense_Mutation_p.F12L|RAB1A_ENST00000494188.1_5'UTR|RAB1A_ENST00000409892.1_Missense_Mutation_p.F12L|RAB1A_ENST00000260638.8_Missense_Mutation_p.F12L|RAB1A_ENST00000398529.3_Missense_Mutation_p.F12L	NM_004161.4	NP_004152.1	P62820	RAB1A_HUMAN	RAB1A, member RAS oncogene family	12					protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	endoplasmic reticulum|Golgi apparatus	GTP binding|GTPase activity			endometrium(1)|kidney(1)|lung(3)|prostate(1)	6						GAAGTAACTTGAATAAATAAT	0.318000													3	16					0	0	1	0	0
DDX18	8886	broad.mit.edu	37	2	118586537	118586537	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:118586537G>A	ENST00000263239.2	+	12	1776	c.1648G>A	c.(1648-1650)Gaa>Aaa	p.E550K		NM_006773.3	NP_006764.3	Q9NVP1	DDX18_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18	550	Helicase C-terminal.						ATP binding|ATP-dependent RNA helicase activity|RNA binding	p.E550K(1)		breast(2)|endometrium(2)|kidney(4)|large_intestine(3)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						TCCATTAAGTGAATTTGACTT	0.398000													11	67					0	0	1	0	0
FNDC3B	64778	broad.mit.edu	37	3	172096176	172096176	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:172096176C>T	ENST00000336824.4	+	24	3224	c.3125C>T	c.(3124-3126)tCa>tTa	p.S1042L	FNDC3B_ENST00000416957.1_Missense_Mutation_p.S1042L|FNDC3B_ENST00000415807.2_Missense_Mutation_p.S1042L	NM_001135095.1	NP_001128567.1	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	1042	Fibronectin type-III 8.					endoplasmic reticulum|integral to membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(12)|lung(26)|ovary(3)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	69	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		GGGCCCTTCTCAGAAACCTAT	0.507000													4	39					0	0	1	0	0
TTC3	7267	broad.mit.edu	37	21	38534361	38534361	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr21:38534361C>T	ENST00000399017.2	+	31	5913	c.3166C>T	c.(3166-3168)Cat>Tat	p.H1056Y	TTC3_ENST00000355666.1_Missense_Mutation_p.H1056Y|TTC3_ENST00000479930.1_3'UTR|TTC3_ENST00000354749.2_Missense_Mutation_p.H1056Y	NM_003316.3	NP_003307.3	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	1056					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(5)|endometrium(7)|kidney(5)|large_intestine(17)|liver(1)|lung(18)|ovary(4)|prostate(2)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(5)	75		Myeloproliferative disorder(46;0.0412)				AAGTGAAGACCATAGGTAAGT	0.264000													5	54					0	0	1	0	0
POLR3C	10623	broad.mit.edu	37	1	145609227	145609227	+	Missense_Mutation	SNP	C	C	G	rs150557296		TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:145609227C>G	ENST00000334163.3	-	2	270	c.110G>C	c.(109-111)aGa>aCa	p.R37T	POLR3C_ENST00000471254.1_5'UTR|POLR3C_ENST00000369294.1_Missense_Mutation_p.R37T	NM_006468.6	NP_006459.3	Q9BUI4	RPC3_HUMAN	polymerase (RNA) III (DNA directed) polypeptide C (62kD)	37					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|regulation of transcription from RNA polymerase III promoter|response to virus	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(3)|liver(1)|lung(8)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)		Epithelial(2;7.55e-13)			GGCAATTACTCTTAGTGGCTG	0.393000													45	76					0	0	1	0	0
BCORL1	63035	broad.mit.edu	37	X	129150108	129150108	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:129150108G>T	ENST00000540052.1	+	3	3404	c.3360G>T	c.(3358-3360)aaG>aaT	p.K1120N	BCORL1_ENST00000303743.5_Missense_Mutation_p.K1120N|BCORL1_ENST00000359304.2_Missense_Mutation_p.K1120N|BCORL1_ENST00000218147.7_Missense_Mutation_p.K1120N	NM_021946.4	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 corepressor-like 1	1120					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						AGAAGATGAAGTGCGGCAAAG	0.562000													10	34					0.00621372	0.00633207	1	1	0
KIAA0226L	80183	broad.mit.edu	37	13	46942248	46942248	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr13:46942248G>C	ENST00000429979.1	-	5	1359	c.755C>G	c.(754-756)tCt>tGt	p.S252C	KIAA0226L_ENST00000389908.3_Missense_Mutation_p.S252C|KIAA0226L_ENST00000378784.4_Missense_Mutation_p.S185C|KIAA0226L_ENST00000378781.3_Missense_Mutation_p.S252C|KIAA0226L_ENST00000322896.6_Missense_Mutation_p.S95C|KIAA0226L_ENST00000378787.3_Missense_Mutation_p.S252C|KIAA0226L_ENST00000409879.2_Missense_Mutation_p.S95C|KIAA0226L_ENST00000378797.2_Missense_Mutation_p.S252C|KIAA0226L_ENST00000534925.1_Missense_Mutation_p.S117C	NM_025113.2	NP_079389.2	Q9H714	CM018_HUMAN	KIAA0226-like	252										NS(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(7)|pancreas(1)	26						AGTCATTTCAGAGTCAGGCTG	0.423000													48	70					0	0	1	0	0
MYO1G	64005	broad.mit.edu	37	7	45009687	45009687	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:45009687C>T	ENST00000258787.7	-	10	1420	c.1284G>A	c.(1282-1284)ctG>ctA	p.L428L		NM_033054.2	NP_149043.2	B0I1T2	MYO1G_HUMAN	myosin IG	428	Myosin head-like.					myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|pancreas(1)|skin(4)	28						GTTCCTGCTTCAGGATGAGCT	0.612000													4	20					0	0	1	0	0
ZSWIM1	90204	broad.mit.edu	37	20	44512264	44512264	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr20:44512264G>A	ENST00000372523.1	+	2	1128	c.1033G>A	c.(1033-1035)Gag>Aag	p.E345K	ZSWIM1_ENST00000372520.1_Missense_Mutation_p.E345K	NM_080603.4	NP_542170.3	Q9BR11	ZSWM1_HUMAN	zinc finger, SWIM-type containing 1	345							zinc ion binding			breast(1)|endometrium(3)|large_intestine(4)|lung(3)|ovary(1)|skin(1)	13		Myeloproliferative disorder(115;0.028)				GTGCCTGGGCGAGCTTGCTGT	0.562000													27	79					0	0	1	0	0
WNK1	65125	broad.mit.edu	37	12	936296	936296	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:936296C>G	ENST00000537687.1	+	3	1664	c.1021C>G	c.(1021-1023)Cga>Gga	p.R341G	WNK1_ENST00000535572.1_Missense_Mutation_p.R341G|WNK1_ENST00000315939.6_Missense_Mutation_p.R341G|WNK1_ENST00000530271.2_Missense_Mutation_p.R341G|WNK1_ENST00000447667.2_Missense_Mutation_p.R341G	NM_001184985.1|NM_213655.4	NP_001171914.1|NP_998820.3	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	341	Protein kinase.				intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity	p.R341G(2)		breast(7)|central_nervous_system(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(43)|ovary(6)|prostate(3)|skin(7)|stomach(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	104	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			TCTTCATACTCGAACTCCACC	0.438000													59	71					0	0	1	0	0
C1orf116	79098	broad.mit.edu	37	1	207196772	207196772	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:207196772C>G	ENST00000359470.5	-	4	586	c.337G>C	c.(337-339)Gag>Cag	p.E113Q	C1orf116_ENST00000461135.2_5'UTR	NM_023938.5	NP_076427.2	Q9BW04	SARG_HUMAN	chromosome 1 open reading frame 116	113						cytoplasm|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(4)|stomach(1)	29	Prostate(682;0.19)					GAGCTGGACTCAGTTACTGTC	0.542000													4	36					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100683527	100683527	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:100683527G>C	ENST00000306151.4	+	3	8894	c.8830G>C	c.(8830-8832)Gag>Cag	p.E2944Q		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2944	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GGCCGGTTCTGAGGCTAGCAC	0.488000													35	170					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132504648	132504648	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:132504648C>A	ENST00000333577.4	+	23	4549	c.4440C>A	c.(4438-4440)ttC>ttA	p.F1480L	EP400_ENST00000332482.4_Missense_Mutation_p.F1407L|EP400_ENST00000330386.6_Missense_Mutation_p.F1444L|EP400_ENST00000389561.2_Missense_Mutation_p.F1444L|EP400_ENST00000389562.2_Missense_Mutation_p.F1443L			Q96L91	EP400_HUMAN	E1A binding protein p400	1480					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		CCGTGGCTTTCCCCAGCACTC	0.647000													19	47					2.4624e-09	2.62601e-09	1	1	0
KCNK13	56659	broad.mit.edu	37	14	90650876	90650876	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr14:90650876G>C	ENST00000282146.4	+	2	1197	c.756G>C	c.(754-756)gaG>gaC	p.E252D		NM_022054.2	NP_071337.2	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	252						integral to membrane	potassium channel activity|voltage-gated ion channel activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(12)|prostate(1)|skin(4)	25		all_cancers(154;0.186)				CCCACTATGAGAGCCAAGGCC	0.493000													11	44					0	0	1	0	0
TBCK	93627	broad.mit.edu	37	4	107168423	107168423	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr4:107168423C>T	ENST00000273980.5	-	11	1251	c.804G>A	c.(802-804)atG>atA	p.M268I	TBCK_ENST00000394706.3_Missense_Mutation_p.M229I|TBCK_ENST00000394708.2_Missense_Mutation_p.M268I|TBCK_ENST00000361687.4_Missense_Mutation_p.M205I|TBCK_ENST00000432496.2_Missense_Mutation_p.M268I			Q8TEA7	TBCK_HUMAN	TBC1 domain containing kinase		Protein kinase.					intracellular	Rab GTPase activator activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)	25						CTTTGTCCTTCATTAATTGAT	0.363000													8	35					0	0	1	0	0
ARID1B	57492	broad.mit.edu	37	6	157505389	157505389	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:157505389G>A	ENST00000346085.5	+	13	3371	c.3370G>A	c.(3370-3372)Gag>Aag	p.E1124K	ARID1B_ENST00000367148.1_Missense_Mutation_p.E1164K|ARID1B_ENST00000275248.4_Missense_Mutation_p.E1106K|ARID1B_ENST00000350026.5_Missense_Mutation_p.E1111K	NM_020732.3	NP_065783.3	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1111	ARID.				chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			NS(2)|breast(5)|central_nervous_system(4)|endometrium(12)|kidney(4)|large_intestine(11)|lung(30)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(3)	81		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		GAAGTGGCGTGAGCTGGCAAC	0.443000													32	43					0	0	1	0	0
TLR10	81793	broad.mit.edu	37	4	38776398	38776398	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr4:38776398C>G	ENST00000308973.4	-	4	1419	c.814G>C	c.(814-816)Gaa>Caa	p.E272Q	TLR10_ENST00000508334.1_Missense_Mutation_p.E272Q|TLR10_ENST00000361424.2_Missense_Mutation_p.E272Q|TLR10_ENST00000506111.1_Missense_Mutation_p.E272Q	NM_001017388.2|NM_001195107.1|NM_030956.3	NP_001017388.1|NP_001182036.1|NP_112218.2	Q9BXR5	TLR10_HUMAN	toll-like receptor 10	272					inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane	transmembrane receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(2)	25						TGAAAGTGTTCCACTGATGTA	0.343000													13	49					0	0	1	0	0
MOAP1	64112	broad.mit.edu	37	14	93650053	93650053	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr14:93650053C>T	ENST00000556883.1	-	2	1019	c.535G>A	c.(535-537)Gaa>Aaa	p.E179K	MOAP1_ENST00000298894.4_Missense_Mutation_p.E179K			Q96BY2	MOAP1_HUMAN	modulator of apoptosis 1	179					activation of caspase activity|apoptotic nuclear change	cytoplasm	protein homodimerization activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|ovary(1)|skin(2)	13		all_cancers(154;0.00528)|Acute lymphoblastic leukemia(33;0.0497)|all_epithelial(191;0.125)|all_neural(303;0.13)		Epithelial(152;0.178)|all cancers(159;0.2)|COAD - Colon adenocarcinoma(157;0.204)		ccaaattcttcttctcctggt	0.502000													6	37					0	0	1	0	0
ETV6	2120	broad.mit.edu	37	12	11992227	11992227	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:11992227C>G	ENST00000396373.4	+	3	591	c.317C>G	c.(316-318)tCt>tGt	p.S106C		NM_001987.4	NP_001978.1	P41212	ETV6_HUMAN	ets variant 6	106	PNT.					cytoplasm|nucleolus	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.Y104fs*14(1)	ETV6/JAK2(11)|ETV6/ITPR2(2)|ETV6/NTRK3(238)	breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(15)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(2;1.88e-12)|Acute lymphoblastic leukemia(2;6.91e-39)|all_hematologic(2;2.7e-36)				CGCTATCGATCTCCTCATTCA	0.463000			T	"""NTRK3, RUNX1, PDGFRB, ABL1, MN1, ABL2, FACL6, CHIC2, ARNT, JAK2, EVI1, CDX2, STL, HLXB9, MDS2, PER1, SYK, TTL, FGFR3, PAX5"""	"""congenital fibrosarcoma, multiple leukemia and lymphoma,  secretory breast, MDS, ALL"""								21	35					0	0	1	0	0
NLGN3	54413	broad.mit.edu	37	X	70367745	70367745	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:70367745G>A	ENST00000374051.3	+	2	468	c.146G>A	c.(145-147)gGg>gAg	p.G49E	NLGN3_ENST00000358741.3_Missense_Mutation_p.G49E|NLGN3_ENST00000536169.1_Missense_Mutation_p.G49E	NM_018977.3	NP_061850.2	Q9NZ94	NLGN3_HUMAN	neuroligin 3	49					neuron cell-cell adhesion|positive regulation of synaptogenesis|receptor-mediated endocytosis|social behavior|synapse assembly	cell surface|endocytic vesicle|integral to plasma membrane|synapse	neurexin binding|receptor activity			biliary_tract(1)|breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(10)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	37	Renal(35;0.156)					ACTCACTTTGGGAAGCTAAGG	0.637000													3	12					0	0	1	0	0
TBC1D23	55773	broad.mit.edu	37	3	100013994	100013994	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:100013994C>T	ENST00000394144.4	+	6	671	c.664C>T	c.(664-666)Cta>Tta	p.L222L	TBC1D23_ENST00000344949.5_Silent_p.L222L|TBC1D23_ENST00000475134.1_Silent_p.L85L|TBC1D23_ENST00000486274.1_3'UTR	NM_001199198.2	NP_001186127.1	Q9NUY8	TBC23_HUMAN	TBC1 domain family, member 23	222	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			breast(1)|endometrium(1)|large_intestine(7)|liver(1)|lung(10)|ovary(1)|prostate(2)|skin(2)	25						GGATGGATATCTACAACAAGC	0.328000													35	50					0	0	1	0	0
TMEM81	388730	broad.mit.edu	37	1	205052985	205052985	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:205052985G>C	ENST00000367167.3	-	1	660	c.464C>G	c.(463-465)tCt>tGt	p.S155C		NM_203376.1	NP_976310.1	Q6P7N7	TMM81_HUMAN	transmembrane protein 81	155	Ig-like.					integral to membrane				endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	9	all_cancers(21;0.144)|Breast(84;0.0437)		BRCA - Breast invasive adenocarcinoma(75;0.0923)			ATATGTCCCAGAGTCATACTC	0.463000													25	51					0	0	1	0	0
PLXNA1	5361	broad.mit.edu	37	3	126735363	126735363	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:126735363G>A	ENST00000251772.4	+	15	3018	c.2949G>A	c.(2947-2949)agG>agA	p.R983R	PLXNA1_ENST00000393409.2_Silent_p.R1006R			Q9UIW2	PLXA1_HUMAN	plexin A1	1006	IPT/TIG 2.				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			breast(3)|central_nervous_system(5)|endometrium(10)|kidney(5)|large_intestine(4)|lung(32)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	67				GBM - Glioblastoma multiforme(114;0.155)		CCTCCAGGAGGAACTCCCGTG	0.642000													5	31					0	0	1	0	0
FAAH2	158584	broad.mit.edu	37	X	57515266	57515266	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:57515266C>G	ENST00000374900.4	+	11	1620	c.1500C>G	c.(1498-1500)atC>atG	p.I500M	FAAH2_ENST00000491179.1_3'UTR	NM_174912.3	NP_777572.2	Q6GMR7	FAAH2_HUMAN	fatty acid amide hydrolase 2	500						integral to membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|hydrolase activity			endometrium(2)|large_intestine(4)|lung(10)|ovary(3)|upper_aerodigestive_tract(3)	22						CTTTAGGCATCCAGGTTGTGG	0.502000										HNSCC(52;0.14)			13	26					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22183587	22183587	+	Silent	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:22183587C>G	ENST00000374695.3	-	44	5575	c.5496G>C	c.(5494-5496)ctG>ctC	p.L1832L		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	1832	Ig-like C2-type 3.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CTGCATCACTCAGCTGGACGT	0.582000													56	68					0	0	1	0	0
UBAC2	337867	broad.mit.edu	37	13	99853753	99853753	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr13:99853753C>T	ENST00000376440.2	+	1	591	c.88C>T	c.(88-90)Cgt>Tgt	p.R30C	UBAC2_ENST00000403766.3_Intron	NM_177967.3	NP_808882.1	Q8NBM4	UBAC2_HUMAN	UBA domain containing 2	0						integral to membrane				breast(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(2)	10	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					GTTAGGAAGTCGTGGCGAGGG	0.493000											OREG0022482	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	33					0	0	1	0	0
COL16A1	1307	broad.mit.edu	37	1	32146636	32146636	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:32146636G>A	ENST00000373672.3	-	38	3087	c.2571C>T	c.(2569-2571)ctC>ctT	p.L857L	COL16A1_ENST00000271069.6_Silent_p.L856L|COL16A1_ENST00000373668.3_Silent_p.L857L	NM_001856.3	NP_001847.3	Q07092	COGA1_HUMAN	collagen, type XVI, alpha 1	857	Triple-helical region 5 (COL5) with 3 imperfections.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(15)|ovary(8)|prostate(4)	48		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		GTGTTCCTCTGAGTCCCGTCT	0.627000													10	16					0	0	1	0	0
UBC	7316	broad.mit.edu	37	12	125397652	125397652	+	Silent	SNP	T	T	C	rs146795524		TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:125397652T>C	ENST00000536769.1	-	1	2242	c.666A>G	c.(664-666)gtA>gtG	p.V222V	UBC_ENST00000339647.5_Silent_p.V222V|UBC_ENST00000538617.1_Intron|UBC_ENST00000546120.1_Silent_p.V146V			P0CG48	UBC_HUMAN	ubiquitin C	222	Ubiquitin-like 3.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			breast(3)|endometrium(4)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		TGAGACGGAGTACCAGGTGCA	0.512000													4	73					0	0	1	0	0
ZMYM3	9203	broad.mit.edu	37	X	70470559	70470559	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:70470559C>G	ENST00000373998.1	-	5	1493	c.796G>C	c.(796-798)Gat>Cat	p.D266H	ZMYM3_ENST00000489332.1_5'UTR|ZMYM3_ENST00000373982.1_Missense_Mutation_p.D268H|ZMYM3_ENST00000314425.5_Missense_Mutation_p.D266H|ZMYM3_ENST00000373984.3_Missense_Mutation_p.D268H|ZMYM3_ENST00000373978.1_Intron|ZMYM3_ENST00000353904.2_Missense_Mutation_p.D266H|ZMYM3_ENST00000373988.1_Missense_Mutation_p.D268H|ZMYM3_ENST00000373981.1_Missense_Mutation_p.D266H	NM_001171162.1	NP_001164633.1	Q14202	ZMYM3_HUMAN	zinc finger, MYM-type 3	266					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(7)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(17)|ovary(1)|prostate(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(35;0.156)					GCATCAGAATCCTCATCTGAC	0.547000													4	13					0	0	1	0	0
CHRDL1	91851	broad.mit.edu	37	X	109919569	109919569	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:109919569C>T	ENST00000218054.4	-	12	1457	c.1261G>A	c.(1261-1263)Gaa>Aaa	p.E421K	CHRDL1_ENST00000372045.1_Missense_Mutation_p.E415K|CHRDL1_ENST00000394797.4_Missense_Mutation_p.E421K|CHRDL1_ENST00000444321.2_Missense_Mutation_p.E422K|CHRDL1_ENST00000434224.1_Missense_Mutation_p.E342K|CHRDL1_ENST00000482160.1_Missense_Mutation_p.E343K|CHRDL1_ENST00000372042.1_Missense_Mutation_p.E423K	NM_001143981.1|NM_001143982.1|NM_145234.3	NP_001137453.1|NP_001137454.1|NP_660277.2	Q9BU40	CRDL1_HUMAN	chordin-like 1	415					BMP signaling pathway|cell differentiation|nervous system development|ossification	extracellular region				endometrium(1)|large_intestine(12)|liver(1)|lung(15)|prostate(1)|skin(1)	31						GCTTCTCCTTCGGTGAAGATC	0.453000													15	37					0	0	1	0	0
PACSIN3	29763	broad.mit.edu	37	11	47202146	47202146	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:47202146G>A	ENST00000539589.1	-	5	649	c.307C>T	c.(307-309)Caa>Taa	p.Q103*	PACSIN3_ENST00000298838.6_Nonsense_Mutation_p.Q103*	NM_001184975.1	NP_001171904.1	Q9UKS6	PACN3_HUMAN	protein kinase C and casein kinase substrate in neurons 3	103					endocytosis|negative regulation of endocytosis|positive regulation of membrane protein ectodomain proteolysis	cytoplasm|plasma membrane	cytoskeletal protein binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)	11						TCCTGCCCTTGCAGCTTCTCC	0.706000													18	29					0	0	1	0	0
KCNC2	3747	broad.mit.edu	37	12	75444196	75444196	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:75444196T>C	ENST00000549446.1	-	3	2269	c.1589A>G	c.(1588-1590)aAt>aGt	p.N530S	KCNC2_ENST00000550433.1_Missense_Mutation_p.N530S|KCNC2_ENST00000548243.1_5'UTR|KCNC2_ENST00000298972.1_Missense_Mutation_p.N530S|KCNC2_ENST00000548513.1_Missense_Mutation_p.N530S|KCNC2_ENST00000540018.1_Missense_Mutation_p.N530S|KCNC2_ENST00000350228.2_Missense_Mutation_p.N530S|KCNC2_ENST00000393288.2_Missense_Mutation_p.N530S|KCNC2_ENST00000341669.3_Missense_Mutation_p.N530S	NM_001260497.1|NM_139137.3	NP_001247426.1|NP_631875.1	Q96PR1	KCNC2_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 2	530					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(28)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	54						CAGAAGTCGATTGTCTTTGCC	0.423000													19	87					0	0	1	0	0
KIF5A	3798	broad.mit.edu	37	12	57961297	57961297	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:57961297C>G	ENST00000455537.2	+	8	884	c.610C>G	c.(610-612)Cgg>Ggg	p.R204G	KIF5A_ENST00000286452.5_Missense_Mutation_p.R115G	NM_004984.2	NP_004975.2	Q12840	KIF5A_HUMAN	kinesin family member 5A	204	Kinesin-motor.|Microtubule-binding.		R -> Q (in SPG10; complicated form).		blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(32)|ovary(2)|prostate(2)|skin(2)	62						ACACAGCTCTCGGAGCCACAG	0.567000													13	13					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149509070	149509070	+	RNA	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:149509070C>T	ENST00000378016.2	+	0	9616							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CCGGTGCCATCGGCACCGGTT	0.697000													9	38					0	0	1	0	0
C22orf29	79680	broad.mit.edu	37	22	19839740	19839740	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr22:19839740G>C	ENST00000405640.1	-	2	713	c.45C>G	c.(43-45)atC>atG	p.I15M	C22orf29_ENST00000328554.4_Missense_Mutation_p.I15M|GNB1L_ENST00000403325.1_Intron|GNB1L_ENST00000329517.6_Intron|C22orf29_ENST00000407472.1_Missense_Mutation_p.I15M|GNB1L_ENST00000405009.1_Intron|C22orf29_ENST00000484072.1_Intron|GNB1L_ENST00000460402.1_Intron			Q7L3V2	CV029_HUMAN	chromosome 22 open reading frame 29	15								p.I15I(1)		NS(1)|large_intestine(1)|lung(3)|prostate(1)|urinary_tract(1)	7	Colorectal(54;0.0993)					CGGCTGCCCAGATGGGAATGC	0.637000													29	44					0	0	1	0	0
CEP128	145508	broad.mit.edu	37	14	81302621	81302621	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr14:81302621G>C	ENST00000555265.1	-	12	1360	c.985C>G	c.(985-987)Caa>Gaa	p.Q329E	CEP128_ENST00000281129.3_Missense_Mutation_p.Q329E|CEP128_ENST00000216517.6_Missense_Mutation_p.Q329E			Q6ZU80	CE128_HUMAN	centrosomal protein 128kDa	329						centriole|spindle pole				NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	51						TGAGATACTTGATGCTGTAAA	0.393000													25	68					0	0	1	0	0
ATP4B	496	broad.mit.edu	37	13	114303727	114303727	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr13:114303727C>G	ENST00000335288.4	-	7	879	c.838G>C	c.(838-840)Gaa>Caa	p.E280Q		NM_000705.3	NP_000696.1	P51164	ATP4B_HUMAN	ATPase, H+/K+ exchanging, beta polypeptide	280					ATP biosynthetic process	integral to membrane|plasma membrane	hydrogen:potassium-exchanging ATPase activity|sodium:potassium-exchanging ATPase activity			breast(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	Lung NSC(43;0.0113)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.00696)|all_epithelial(44;0.00347)|all_lung(25;0.0221)|Breast(118;0.0411)|Lung NSC(25;0.0839)	all cancers(43;0.171)		Rabeprazole(DB01129)	ACTTTCCCTTCATACGGGTCG	0.587000													3	10					0	0	1	0	0
OR10J3	441911	broad.mit.edu	37	1	159284232	159284232	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:159284232C>T	ENST00000332217.5	-	1	217	c.218G>A	c.(217-219)tGc>tAc	p.C73Y		NM_001004467.1	NP_001004467.1	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J, member 3	73					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(7)|kidney(4)|large_intestine(7)|lung(19)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	47	all_hematologic(112;0.0429)					CACAGTGTAGCAGGTCTCAGA	0.488000													11	89					0	0	1	0	0
USP46	64854	broad.mit.edu	37	4	53476749	53476749	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr4:53476749G>A	ENST00000441222.3	-	5	780	c.596C>T	c.(595-597)tCt>tTt	p.S199F	USP46_ENST00000508499.1_Missense_Mutation_p.S192F|USP46_ENST00000451218.2_Missense_Mutation_p.S172F	NM_022832.3	NP_073743.2	P62068	UBP46_HUMAN	ubiquitin specific peptidase 46						behavior|protein deubiquitination|regulation of synaptic transmission, GABAergic|ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|endometrium(2)|large_intestine(2)|lung(5)|ovary(2)	12			LUSC - Lung squamous cell carcinoma(32;0.0295)			CACATCAACAGAAAGGTCAAG	0.358000													4	32					0	0	1	0	0
TMEFF2	23671	broad.mit.edu	37	2	193044353	193044353	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:193044353C>T	ENST00000409056.3	-	4	479	c.480G>A	c.(478-480)tgG>tgA	p.W160*	TMEFF2_ENST00000392314.1_Intron|TMEFF2_ENST00000272771.5_Intron			Q9UIK5	TEFF2_HUMAN	transmembrane protein with EGF-like and two follistatin-like domains 2	0						extracellular region|integral to membrane				breast(2)|cervix(1)|kidney(2)|large_intestine(4)|liver(1)|lung(12)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27			OV - Ovarian serous cystadenocarcinoma(117;0.0835)			ATAATAATATCCACCAGTAAA	0.313000													8	42					0	0	1	0	0
ROCK2	9475	broad.mit.edu	37	2	11426712	11426712	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:11426712C>T	ENST00000315872.6	-	3	725	c.277G>A	c.(277-279)Gat>Aat	p.D93N	ROCK2_ENST00000462366.1_5'UTR	NM_004850.3	NP_004841.2	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein kinase 2	93	Protein kinase.				axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(6)|lung(10)|prostate(1)|skin(4)|stomach(3)|urinary_tract(2)	43	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		TTTACAACATCATAGTCTTCT	0.318000													26	110					0	0	1	0	0
GPR101	83550	broad.mit.edu	37	X	136113687	136113687	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:136113687G>A	ENST00000298110.1	-	1	146	c.147C>T	c.(145-147)aaC>aaT	p.N49N		NM_054021.1	NP_473362.1	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	49						integral to membrane|plasma membrane	G-protein coupled receptor activity			autonomic_ganglia(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(18)|ovary(3)|skin(1)|urinary_tract(1)	42	Acute lymphoblastic leukemia(192;0.000127)					CCAGCACTATGTTGCCGACGA	0.582000													25	79					0	0	1	0	0
ZNF584	201514	broad.mit.edu	37	19	58928190	58928190	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:58928190G>A	ENST00000306910.4	+	4	828	c.305G>A	c.(304-306)aGa>aAa	p.R102K	ZNF584_ENST00000322834.7_Missense_Mutation_p.E135K|ZNF584_ENST00000593920.1_Missense_Mutation_p.R57K|ZNF584_ENST00000596921.1_3'UTR|ZNF584_ENST00000599238.1_3'UTR	NM_173548.1	NP_775819.1	Q8IVC4	ZN584_HUMAN	zinc finger protein 584	102					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(3)|lung(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	14		all_cancers(17;5.3e-17)|all_epithelial(17;3.71e-12)|Lung NSC(17;8.3e-05)|Colorectal(82;0.000147)|all_lung(17;0.000386)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0271)		GGTTTGTGTAGAGTGGAGGAT	0.483000													4	29					0	0	1	0	0
PCNA	5111	broad.mit.edu	37	20	5096165	5096165	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr20:5096165C>T	ENST00000379160.3	-	6	878	c.636G>A	c.(634-636)ctG>ctA	p.L212L	PCNA_ENST00000379143.5_Silent_p.L212L	NM_002592.2	NP_002583.1	P12004	PCNA_HUMAN	proliferating cell nuclear antigen	212					cell proliferation|DNA strand elongation involved in DNA replication|mismatch repair|nucleotide-excision repair, DNA gap filling|phosphatidylinositol-mediated signaling|positive regulation of deoxyribonuclease activity|regulation of DNA replication|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair|translesion synthesis	cytoplasm|DNA replication factor C complex|microtubule cytoskeleton|nuclear replication fork|nucleoplasm|PCNA complex|PCNA-p21 complex	dinucleotide insertion or deletion binding|DNA polymerase processivity factor activity|MutLalpha complex binding|purine-specific mismatch base pair DNA N-glycosylase activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(2)	9						TAAAGAAGTTCAGGTACCTCA	0.368000								DNA polymerases (catalytic subunits)					16	98					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14812908	14812908	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr9:14812908C>G	ENST00000380881.4	-	17	3613	c.2798G>C	c.(2797-2799)cGc>cCc	p.R933P	FREM1_ENST00000422223.2_Missense_Mutation_p.R932P|FREM1_ENST00000380880.3_Missense_Mutation_p.R932P			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	932					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		CTGAGGTTCGCGAGCAATCAC	0.478000													7	116					0	0	1	0	0
FABP1	2168	broad.mit.edu	37	2	88424061	88424061	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:88424061G>C	ENST00000393750.3	-	3	316	c.285C>G	c.(283-285)ttC>ttG	p.F95L	FABP1_ENST00000495375.1_5'UTR|FABP1_ENST00000295834.3_Missense_Mutation_p.F95L			P07148	FABPL_HUMAN	fatty acid binding protein 1, liver	95					organ morphogenesis					kidney(1)|large_intestine(1)|lung(2)|prostate(1)|stomach(1)	6						TGATGTTTTTGAAAGTTGTCA	0.527000													15	117					0	0	1	0	0
CNTN2	6900	broad.mit.edu	37	1	205041086	205041086	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:205041086G>C	ENST00000331830.4	+	20	2840	c.2556G>C	c.(2554-2556)tgG>tgC	p.W852C		NM_005076.3	NP_005067.1	Q02246	CNTN2_HUMAN	contactin 2 (axonal)	852	Fibronectin type-III 3.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(11)|lung(23)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	54	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			TCCGCTACTGGAAAGCTGGGG	0.617000													7	14					0	0	1	0	0
SOS1	6654	broad.mit.edu	37	2	39249918	39249918	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:39249918C>T	ENST00000426016.1	-	11	1737	c.1651G>A	c.(1651-1653)Gaa>Aaa	p.E551K	SOS1_ENST00000395038.2_Missense_Mutation_p.E551K|SOS1_ENST00000402219.2_Missense_Mutation_p.E551K			Q07889	SOS1_HUMAN	son of sevenless homolog 1 (Drosophila)	551					apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(29)|ovary(4)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	75		all_hematologic(82;0.21)				AGCATCCTTTCCAGTGTACTC	0.398000									Noonan syndrome				46	62					0	0	1	0	0
JAG1	182	broad.mit.edu	37	20	10639261	10639261	+	Silent	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr20:10639261G>T	ENST00000254958.5	-	4	1064	c.549C>A	c.(547-549)atC>atA	p.I183I	JAG1_ENST00000423891.2_Silent_p.I24I	NM_000214.2	NP_000205.1	P78504	JAG1_HUMAN	jagged 1	183					angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|pancreas(1)|urinary_tract(1)	44						AGGTCACGCGGATCTGATACT	0.522000									Alagille Syndrome				8	69					0.00448238	0.00458718	1	1	0
TLE1	7088	broad.mit.edu	37	9	84205815	84205815	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr9:84205815G>A	ENST00000376499.3	-	16	2798	c.1734C>T	c.(1732-1734)taC>taT	p.Y578Y		NM_005077.3	NP_005068.2	Q04724	TLE1_HUMAN	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	578					negative regulation of Wnt receptor signaling pathway|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway		transcription factor binding			NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	29						TGGCCAGGGCGTAGCAGGCGG	0.617000													15	61					0	0	1	0	0
FANCG	2189	broad.mit.edu	37	9	35077035	35077035	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr9:35077035G>C	ENST00000378643.3	-	6	1201	c.710C>G	c.(709-711)tCa>tGa	p.S237*		NM_004629.1	NP_004620.1	O15287	FANCG_HUMAN	Fanconi anemia, complementation group G	237					cell cycle checkpoint|DNA repair|mitochondrion organization	mitochondrion|nucleoplasm	damaged DNA binding|protein binding			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(7)|ovary(2)|prostate(3)|stomach(1)	28			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			ACACAGGCCTGAGGCCGCTTC	0.572000			"""Mis, N, F, S"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks					24	35					0	0	1	0	0
HPX	3263	broad.mit.edu	37	11	6461461	6461461	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:6461461C>T	ENST00000265983.3	-	4	370	c.270G>A	c.(268-270)tgG>tgA	p.W90*	HPX_ENST00000525057.1_5'UTR	NM_000613.2	NP_000604.1	P02790	HEMO_HUMAN	hemopexin	90	Hemopexin-like 1.				cellular iron ion homeostasis|interspecies interaction between organisms	extracellular space	heme transporter activity|metal ion binding|protein binding			endometrium(1)|large_intestine(2)|lung(11)|prostate(1)	15		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;5.46e-08)|BRCA - Breast invasive adenocarcinoma(625;0.19)		GGAAATTCTTCCATCTCTCTG	0.512000													18	46					0	0	1	0	0
ZSWIM4	65249	broad.mit.edu	37	19	13923877	13923877	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:13923877A>T	ENST00000254323.2	+	6	1268	c.1079A>T	c.(1078-1080)cAg>cTg	p.Q360L	ZSWIM4_ENST00000440752.2_Missense_Mutation_p.Q77L	NM_023072.2	NP_075560.2	Q9H7M6	ZSWM4_HUMAN	zinc finger, SWIM-type containing 4	360							zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27			OV - Ovarian serous cystadenocarcinoma(19;2.94e-23)|Epithelial(5;4.58e-19)			GGCTGGCTCCAGCTACTCAGC	0.657000													4	24					0	0	1	0	0
KIF4B	285643	broad.mit.edu	37	5	154396459	154396459	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr5:154396459C>G	ENST00000435029.4	+	1	3200	c.3040C>G	c.(3040-3042)Cca>Gca	p.P1014A		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	1014	Globular (By similarity).|Interaction with PRC1 (By similarity).				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			CCTTCTATCTCCAGACTCTTC	0.413000													31	41					0	0	1	0	0
LAMB1	3912	broad.mit.edu	37	7	107564714	107564714	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:107564714G>C	ENST00000393561.1	-	31	5441	c.5257C>G	c.(5257-5259)Ctt>Gtt	p.L1753V	LAMB1_ENST00000222399.6_Missense_Mutation_p.L1729V			P07942	LAMB1_HUMAN	laminin, beta 1	1729	Domain I.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			NS(3)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(37)|ovary(6)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)	82					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGAGCTAAAAGAGTTTTTGCT	0.333000													39	87					0	0	1	0	0
SLC52A2	79581	broad.mit.edu	37	8	145582986	145582986	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr8:145582986G>A	ENST00000532887.1	+	2	616	c.33G>A	c.(31-33)ctG>ctA	p.L11L	SLC52A2_ENST00000527078.1_Silent_p.L11L|SLC52A2_ENST00000526752.1_Silent_p.L11L|SLC52A2_ENST00000526891.1_Intron|SLC52A2_ENST00000530047.1_Silent_p.L11L|SLC52A2_ENST00000402965.1_Silent_p.L11L|SLC52A2_ENST00000540505.1_Intron|SLC52A2_ENST00000329994.2_Silent_p.L11L			Q9HAB3	RFT3_HUMAN	solute carrier family 52 (riboflavin transporter), member 2	11						integral to plasma membrane	receptor activity|riboflavin transporter activity										GTCCGGTGCTGACCCACCTGC	0.642000													10	21					0	0	1	0	0
ZNF675	171392	broad.mit.edu	37	19	23844937	23844937	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:23844937C>T	ENST00000359788.4	-	3	373	c.205G>A	c.(205-207)Gag>Aag	p.E69K	ZNF675_ENST00000600313.1_Missense_Mutation_p.E69K|ZNF675_ENST00000599168.1_Missense_Mutation_p.E69K|ZNF675_ENST00000601010.1_Missense_Mutation_p.E69K|ZNF675_ENST00000596211.1_Missense_Mutation_p.E69K|ZNF675_ENST00000601935.1_Missense_Mutation_p.E69K	NM_138330.2	NP_612203.2	Q8TD23	ZN675_HUMAN	zinc finger protein 675	69	KRAB.				bone resorption|cytokine-mediated signaling pathway|hemopoiesis|I-kappaB kinase/NF-kappaB cascade|negative regulation of JNK cascade|negative regulation of osteoclast differentiation|negative regulation of protein kinase activity|negative regulation of transcription, DNA-dependent|regulation of ossification|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	27		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				TTCACCATCTCATGTCTCTTC	0.398000													15	76					0	0	1	0	0
OCRL	4952	broad.mit.edu	37	X	128710427	128710427	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:128710427C>T	ENST00000371113.4	+	18	2178	c.2013C>T	c.(2011-2013)atC>atT	p.I671I	OCRL_ENST00000357121.5_Silent_p.I671I	NM_000276.3	NP_000267.2	Q01968	OCRL_HUMAN	oculocerebrorenal syndrome of Lowe	671					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	clathrin-coated vesicle|cytosol|early endosome|Golgi stack|Golgi-associated vesicle	GTPase activator activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			breast(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(24)|ovary(2)|upper_aerodigestive_tract(3)	48						TCTTGACTATCAGTGGAAATT	0.433000													30	54					0	0	1	0	0
ZRANB3	84083	broad.mit.edu	37	2	136261993	136261993	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:136261993C>G	ENST00000401392.1	-	2	279	c.67G>C	c.(67-69)Gat>Cat	p.D23H	ZRANB3_ENST00000536680.1_Missense_Mutation_p.D23H|ZRANB3_ENST00000264159.6_Missense_Mutation_p.D23H			Q5FWF4	ZRAB3_HUMAN	zinc finger, RAN-binding domain containing 3	23						intracellular	ATP binding|DNA binding|endonuclease activity|helicase activity|zinc ion binding			NS(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(10)|upper_aerodigestive_tract(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.135)		AGCAGATTATCAGATTCATTT	0.368000													10	36					0	0	1	0	0
TRAV13-2	28670	broad.mit.edu	37	14	22386865	22386865	+	RNA	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr14:22386865C>A	ENST00000390439.2	+	0	344																											GACAGTGAAACATCTCTCTCT	0.413000													5	20					0.000602214	0.000620913	1	1	0
OR5D14	219436	broad.mit.edu	37	11	55563880	55563880	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:55563880C>T	ENST00000335605.1	+	1	849	c.849C>T	c.(847-849)gtC>gtT	p.V283V		NM_001004735.1	NP_001004735.1	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D, member 14	283					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(30)|ovary(2)|prostate(1)|skin(2)|stomach(3)|urinary_tract(1)	48		all_epithelial(135;0.196)				ACACAGTTGTCAACCCCATGC	0.433000													11	56					0	0	1	0	0
ACPT	93650	broad.mit.edu	37	19	51298100	51298100	+	Silent	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:51298100C>G	ENST00000270593.1	+	10	1044	c.1044C>G	c.(1042-1044)ctC>ctG	p.L348L	ACPT_ENST00000270594.3_Silent_p.L255L	NM_033068.2	NP_149059.1	Q9BZG2	PPAT_HUMAN	acid phosphatase, testicular	348						integral to membrane	acid phosphatase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|skin(3)	11		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		CCCTGCCTCTCAGCCTCCCCG	0.677000													44	143					0	0	1	0	0
INF2	64423	broad.mit.edu	37	14	105178831	105178831	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr14:105178831G>A	ENST00000392634.4	+	17	2663	c.2551G>A	c.(2551-2553)Gag>Aag	p.E851K	INF2_ENST00000330634.7_Missense_Mutation_p.E851K	NM_022489.3	NP_071934.3	Q27J81	INF2_HUMAN	inverted formin, FH2 and WH2 domain containing	851	FH2.				actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding			large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		TCTGGAGACCGAGCGGAAGGT	0.652000													6	25					0	0	1	0	0
IL16	3603	broad.mit.edu	37	15	81592368	81592368	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr15:81592368G>A	ENST00000394660.2	+	14	3061	c.2701G>A	c.(2701-2703)Gag>Aag	p.E901K	IL16_ENST00000560230.1_3'UTR|IL16_ENST00000302987.4_Missense_Mutation_p.E901K|IL16_ENST00000394652.2_Missense_Mutation_p.E200K	NM_001172128.1|NM_172217.3	NP_001165599.1|NP_757366.2	Q14005	IL16_HUMAN	interleukin 16	901					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(12)|lung(20)|ovary(3)|skin(3)|stomach(1)|urinary_tract(1)	57						CCAGCAGCCTGAGCAAGTACT	0.627000													10	35					0	0	1	0	0
IDI2	91734	broad.mit.edu	37	10	1070588	1070588	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr10:1070588C>T	ENST00000277517.1	-	2	140	c.76G>A	c.(76-78)Gag>Aag	p.E26K	IDI2-AS1_ENST00000428780.2_RNA|IDI2-AS1_ENST00000437374.1_RNA|IDI2-AS1_ENST00000420381.1_RNA|IDI2-AS1_ENST00000536039.1_RNA|IDI2-AS1_ENST00000434470.1_RNA	NM_033261.2	NP_150286.1	Q9BXS1	IDI2_HUMAN	isopentenyl-diphosphate delta isomerase 2	26					carotenoid biosynthetic process|cholesterol biosynthetic process	cytosol|peroxisome	hydrolase activity|isopentenyl-diphosphate delta-isomerase activity|metal ion binding			kidney(1)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	9		Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.143)	Epithelial(11;0.067)|OV - Ovarian serous cystadenocarcinoma(14;0.169)|all cancers(11;0.192)		TTATCATTCTCATCCACAACA	0.493000													13	58					0	0	1	0	0
PPP2R1B	5519	broad.mit.edu	37	11	111608256	111608256	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:111608256C>T	ENST00000311129.5	-	15	1847	c.1827G>A	c.(1825-1827)gtG>gtA	p.V609V	PPP2R1B_ENST00000426998.2_Silent_p.V545V	NM_181699.2	NP_859050.1	P30154	2AAB_HUMAN	protein phosphatase 2, regulatory subunit A, beta	0							protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|liver(1)|lung(10)|prostate(1)|urinary_tract(2)	22		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|Epithelial(105;2.36e-06)|all cancers(92;3.78e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0761)		CACTGTCCTTCACAGGAAATT	0.577000													14	44					0	0	1	0	0
CLP1	10978	broad.mit.edu	37	11	57426958	57426958	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:57426958G>A	ENST00000533682.1	+	2	735	c.10G>A	c.(10-12)Gag>Aag	p.E4K	CLP1_ENST00000529430.1_Missense_Mutation_p.E15K|CLP1_ENST00000302731.4_Missense_Mutation_p.E4K|CLP1_ENST00000525602.1_Missense_Mutation_p.E4K			Q92989	CLP1_HUMAN	cleavage and polyadenylation factor I subunit 1	4					mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|siRNA loading onto RISC involved in RNA interference|targeting of mRNA for destruction involved in RNA interference|termination of RNA polymerase II transcription|tRNA splicing, via endonucleolytic cleavage and ligation	nucleoplasm|tRNA-intron endonuclease complex	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|stomach(1)	15						GATGGGAGAAGAGGCTAATGA	0.413000													4	34					0	0	1	0	0
HERC3	8916	broad.mit.edu	37	4	89599246	89599246	+	Silent	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr4:89599246G>C	ENST00000402738.1	+	19	2396	c.2157G>C	c.(2155-2157)ctG>ctC	p.L719L	HERC3_ENST00000543130.1_Silent_p.L163L|HERC3_ENST00000264345.3_Silent_p.L719L	NM_001271602.1|NM_014606.1	NP_001258531.1|NP_055421.1	Q15034	HERC3_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 3	719					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasmic membrane-bounded vesicle	ubiquitin-protein ligase activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(14)|prostate(2)|skin(2)	45				OV - Ovarian serous cystadenocarcinoma(123;0.000319)		TAAGAGAGCTGAGCATTCATT	0.453000													17	56					0	0	1	0	0
GON4L	54856	broad.mit.edu	37	1	155783560	155783560	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:155783560G>A	ENST00000437809.1	-	10	1439	c.1317C>T	c.(1315-1317)atC>atT	p.I439I	GON4L_ENST00000471341.1_5'UTR|GON4L_ENST00000368331.1_Silent_p.I439I|GON4L_ENST00000361040.5_Silent_p.I439I|GON4L_ENST00000271883.5_Silent_p.I439I	NM_001282856.1	NP_001269785.1	Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	439					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					CCTCAGCACTGATGTGCCTGA	0.488000													15	46					0	0	1	0	0
ENTPD3	956	broad.mit.edu	37	3	40464485	40464485	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:40464485G>C	ENST00000301825.3	+	8	1094	c.976G>C	c.(976-978)Gaa>Caa	p.E326Q	ENTPD3_ENST00000456402.1_Missense_Mutation_p.E326Q|ENTPD3-AS1_ENST00000452768.1_RNA|ENTPD3-AS1_ENST00000425156.1_RNA|ENTPD3_ENST00000445129.1_Missense_Mutation_p.E326Q|ENTPD3-AS1_ENST00000439293.1_RNA	NM_001248.2	NP_001239.2	O75355	ENTP3_HUMAN	ectonucleoside triphosphate diphosphohydrolase 3	326						integral to membrane	ATP binding|hydrolase activity			endometrium(1)|kidney(3)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18				KIRC - Kidney renal clear cell carcinoma(284;0.0605)|Kidney(284;0.0758)		CATCACTTTTGAAGGAACTGG	0.448000													23	61					0	0	1	0	0
BCAT2	587	broad.mit.edu	37	19	49303531	49303531	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:49303531G>C	ENST00000402551.1	-	5	824	c.204C>G	c.(202-204)ttC>ttG	p.F68L	BCAT2_ENST00000599246.1_Missense_Mutation_p.F16L|BCAT2_ENST00000545387.2_Missense_Mutation_p.F16L|BCAT2_ENST00000597011.1_Missense_Mutation_p.F68L|BCAT2_ENST00000316273.6_Missense_Mutation_p.F108L|BCAT2_ENST00000598162.1_Missense_Mutation_p.F108L	NM_001284325.1	NP_001271254.1	O15382	BCAT2_HUMAN	branched chain amino-acid transaminase 2, mitochondrial	108						mitochondrial matrix	L-isoleucine transaminase activity|L-leucine transaminase activity|L-valine transaminase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|ovary(2)|skin(1)	12		all_epithelial(76;7e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000138)|all cancers(93;0.000366)|Epithelial(262;0.0195)|GBM - Glioblastoma multiforme(486;0.0224)	L-Glutamic Acid(DB00142)|L-Isoleucine(DB00167)|L-Leucine(DB00149)|Pyridoxal Phosphate(DB00114)	CTTTGCCTTTGAACGCCTTCA	0.627000													10	39					0	0	1	0	0
PPP1R21	129285	broad.mit.edu	37	2	48685295	48685295	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:48685295C>G	ENST00000294952.8	+	4	461	c.304C>G	c.(304-306)Caa>Gaa	p.Q102E	PPP1R21_ENST00000281394.4_Missense_Mutation_p.Q102E|PPP1R21_ENST00000449090.2_Missense_Mutation_p.Q102E	NM_001135629.2	NP_001129101.1	Q6ZMI0	KLRAQ_HUMAN	protein phosphatase 1, regulatory subunit 21	102										endometrium(2)|kidney(4)|lung(9)	15						TCAGTTGAGTCAAGAGCAGAA	0.348000													14	132					0	0	1	0	0
KCNAB3	9196	broad.mit.edu	37	17	7829275	7829275	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr17:7829275G>C	ENST00000303790.2	-	6	467	c.468C>G	c.(466-468)atC>atG	p.I156M	RP11-1099M24.7_ENST00000573621.1_3'UTR	NM_004732.3	NP_004723.2	O43448	KCAB3_HUMAN	potassium voltage-gated channel, shaker-related subfamily, beta member 3	156						cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			breast(2)|endometrium(2)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)	8		Prostate(122;0.157)				TCTTGGTAGTGATGACATAGC	0.488000													49	43					0	0	1	0	0
GPR158	57512	broad.mit.edu	37	10	25887151	25887151	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr10:25887151G>A	ENST00000376351.3	+	11	2955	c.2596G>A	c.(2596-2598)Gag>Aag	p.E866K	GPR158_ENST00000490549.1_3'UTR	NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	866						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						AGAAGACAGCGAGGCTGAGTC	0.498000													10	64					0	0	1	0	0
SPICE1	152185	broad.mit.edu	37	3	113218358	113218358	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:113218358C>G	ENST00000295872.4	-	4	478	c.219G>C	c.(217-219)ttG>ttC	p.L73F		NM_144718.3	NP_653319.1	Q8N0Z3	SPICE_HUMAN	spindle and centriole associated protein 1	73					cell division|mitosis	centriole|spindle	protein binding			NS(1)|autonomic_ganglia(1)|breast(4)|endometrium(3)|large_intestine(9)|lung(10)|ovary(2)|skin(2)|urinary_tract(1)	33						ATTTTCTCTTCAAAGCTTTTT	0.358000													4	30					0	0	1	0	0
ZC3H7A	29066	broad.mit.edu	37	16	11859511	11859511	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr16:11859511G>C	ENST00000396516.2	-	13	1750	c.1553C>G	c.(1552-1554)tCa>tGa	p.S518*	ZC3H7A_ENST00000355758.4_Nonsense_Mutation_p.S518*			Q8IWR0	Z3H7A_HUMAN	zinc finger CCCH-type containing 7A	518						nucleus	nucleic acid binding|zinc ion binding			breast(2)|endometrium(3)|kidney(5)|large_intestine(2)|liver(1)|lung(3)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(2)	25						GCAGTGGCCTGAATATCTACA	0.502000													11	30					0	0	1	0	0
DIMT1	27292	broad.mit.edu	37	5	61688797	61688797	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr5:61688797C>T	ENST00000199320.4	-	9	844	c.684G>A	c.(682-684)agG>agA	p.R228R	DIMT1_ENST00000506390.1_Silent_p.R228R|KIF2A_ENST00000509663.2_Intron	NM_014473.2	NP_055288.1	Q9UNQ2	DIMT1_HUMAN	DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)	228						nucleolus	RNA binding|rRNA (adenine-N6,N6-)-dimethyltransferase activity										CAAAGGTTATCCTTACTAGAC	0.343000													11	53					0	0	1	0	0
TUBA3E	112714	broad.mit.edu	37	2	130952744	130952744	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:130952744C>T	ENST00000312988.7	-	3	383	c.283G>A	c.(283-285)Ggg>Agg	p.G95R		NM_207312.2	NP_997195	Q6PEY2	TBA3E_HUMAN	tubulin, alpha 3e	95					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			endometrium(4)|kidney(7)|large_intestine(6)|lung(9)|skin(2)	28	Colorectal(110;0.1)					TCTTCCTTCCCGGTGATCAGC	0.522000													9	96					0	0	1	0	0
APLP2	334	broad.mit.edu	37	11	129991605	129991605	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:129991605C>G	ENST00000263574.5	+	5	685	c.613C>G	c.(613-615)Cag>Gag	p.Q205E	APLP2_ENST00000345598.5_Intron|APLP2_ENST00000338167.5_Missense_Mutation_p.Q205E|APLP2_ENST00000528499.1_Missense_Mutation_p.Q205E|APLP2_ENST00000539648.1_Missense_Mutation_p.Q49E|APLP2_ENST00000278756.7_Missense_Mutation_p.Q215E|APLP2_ENST00000543137.1_Missense_Mutation_p.Q112E	NM_001642.2	NP_001633.1	Q06481	APLP2_HUMAN	amyloid beta (A4) precursor-like protein 2	205					G-protein coupled receptor protein signaling pathway	integral to membrane|nucleus|plasma membrane	DNA binding|identical protein binding|serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(6)|ovary(4)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_hematologic(175;0.0429)	Breast(109;0.00586)|Lung NSC(97;0.00785)|all_lung(97;0.0154)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0197)|Lung(977;0.24)		GTGCTGCCCTCAGACAAAGAT	0.443000													26	144					0	0	1	0	0
DNAJC22	79962	broad.mit.edu	37	12	49743189	49743189	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:49743189C>T	ENST00000549441.2	+	3	1738	c.534C>T	c.(532-534)ctC>ctT	p.L178L	DNAJC22_ENST00000395069.3_Silent_p.L178L			Q8N4W6	DJC22_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 22	178					protein folding	integral to membrane	heat shock protein binding|unfolded protein binding	p.L178L(2)		breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|liver(2)|lung(1)|ovary(1)|pancreas(1)	10						CAGAGCCGCTCAGTGTGCGGC	0.587000													16	53					0	0	1	0	0
PTPN6	5777	broad.mit.edu	37	12	7060782	7060782	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:7060782C>T	ENST00000456013.1	+	2	261	c.19C>T	c.(19-21)Cga>Tga	p.R7*	PTPN6_ENST00000447931.2_Intron|PTPN6_ENST00000318974.9_Nonsense_Mutation_p.R7*|PTPN6_ENST00000399448.1_Nonsense_Mutation_p.R9*	NM_080549.3	NP_536859.1	P29350	PTN6_HUMAN	protein tyrosine phosphatase, non-receptor type 6	7	SH2 1.				apoptosis|cell junction assembly|G-protein coupled receptor protein signaling pathway|interferon-gamma-mediated signaling pathway|leukocyte migration|negative regulation of peptidyl-tyrosine phosphorylation|platelet activation|positive regulation of cell proliferation|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of G1/S transition of mitotic cell cycle|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|T cell costimulation|type I interferon-mediated signaling pathway	cytosol|membrane|nucleus	protein binding|protein tyrosine phosphatase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|prostate(3)	18						GTGGTTTCACCGAGACCTCAG	0.662000													8	45					0	0	1	0	0
TRMT112	51504	broad.mit.edu	37	11	64084438	64084438	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:64084438C>T	ENST00000544844.1	-	4	830	c.273G>A	c.(271-273)gtG>gtA	p.V91V	TRMT112_ENST00000535750.1_Silent_p.V47V|TRMT112_ENST00000535126.1_3'UTR|TRMT112_ENST00000539854.1_3'UTR|TRMT112_ENST00000308774.2_Silent_p.V86V			Q9UI30	TR112_HUMAN	tRNA methyltransferase 11-2 homolog (S. cerevisiae)	91	TRM112.				peptidyl-glutamine methylation	protein complex	protein binding|protein methyltransferase activity			large_intestine(1)|upper_aerodigestive_tract(1)	2						CTATCACTTCCACCTGCGGGC	0.627000													14	39					0	0	1	0	0
CUBN	8029	broad.mit.edu	37	10	17089552	17089552	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr10:17089552A>C	ENST00000377833.4	-	23	3255	c.3190T>G	c.(3190-3192)Ttc>Gtc	p.F1064V		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	1064	CUB 6.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TTATTGGGGAAGTTTGGAGAA	0.403000													6	58					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24488161	24488161	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr5:24488161C>T	ENST00000264463.4	-	12	2485	c.1978G>A	c.(1978-1980)Gag>Aag	p.E660K	CDH10_ENST00000502921.1_5'UTR	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	660					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		CCACCACCCTCATCGTTATAG	0.453000										HNSCC(23;0.051)			21	114					0	0	1	0	0
SYT4	6860	broad.mit.edu	37	18	40853974	40853974	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr18:40853974C>T	ENST00000255224.3	-	2	788	c.420G>A	c.(418-420)aaG>aaA	p.K140K	SYT4_ENST00000590752.1_Silent_p.K122K|SYT4_ENST00000586678.1_Intron	NM_020783.3	NP_065834.1	Q9H2B2	SYT4_HUMAN	synaptotagmin IV	140						cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	44						AAGTGCTGGACTTTAAACTCT	0.433000													5	41					0	0	1	0	0
SLC24A3	57419	broad.mit.edu	37	20	19665975	19665975	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr20:19665975G>C	ENST00000328041.6	+	12	1491	c.1294G>C	c.(1294-1296)Gaa>Caa	p.E432Q		NM_020689.3	NP_065740.2	Q9HC58	NCKX3_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 3	432						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						ggatgatgatgaagGACCGTA	0.507000													8	50					0	0	1	0	0
SGOL2	151246	broad.mit.edu	37	2	201437404	201437404	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:201437404G>T	ENST00000357799.4	+	7	2433	c.2335G>T	c.(2335-2337)Gat>Tat	p.D779Y		NM_001160033.1|NM_001160046.1|NM_152524.5	NP_001153505.1|NP_001153518.1|NP_689737.4	Q562F6	SGOL2_HUMAN	shugoshin-like 2 (S. pombe)	779					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			NS(2)|breast(2)|cervix(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	46						AAACCTGTATGATTCTGAGAT	0.378000													25	37					1.42536e-11	1.53537e-11	1	1	0
PRDM7	11105	broad.mit.edu	37	16	90128810	90128810	+	Splice_Site	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr16:90128810G>A	ENST00000449207.2	-	6	628	c.609C>T	c.(607-609)ctC>ctT	p.L203L	PRDM7_ENST00000407825.1_5'UTR	NM_001098173.1	NP_001091643.1	Q9NQW5	PRDM7_HUMAN	PR domain containing 7	203						chromosome|nucleus	nucleic acid binding			lung(2)|ovary(2)|stomach(1)	5		all_cancers(9;4.44e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.00118)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		GTCACTCACAGAGGTAGTCAT	0.448000													22	85					0	0	1	0	0
PCDHB7	56129	broad.mit.edu	37	5	140554439	140554439	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr5:140554439G>C	ENST00000231137.3	+	1	2197	c.2023G>C	c.(2023-2025)Gag>Cag	p.E675Q		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		675					calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCGGCTCCCGGAGGCGGCCCC	0.692000													26	173					0	0	1	0	0
IGKV2-30	28919	broad.mit.edu	37	2	89544435	89544435	+	RNA	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:89544435C>T	ENST00000468494.1	-	0	218																											GGCCTGGCCTCTGCTGAAACC	0.542000													14	131					0	0	1	0	0
CDCA2	157313	broad.mit.edu	37	8	25323728	25323728	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr8:25323728G>T	ENST00000330560.3	+	5	902	c.425G>T	c.(424-426)aGa>aTa	p.R142I	CDCA2_ENST00000380665.3_Missense_Mutation_p.R127I	NM_152562.2	NP_689775.2	Q69YH5	CDCA2_HUMAN	cell division cycle associated 2	142					cell division|mitosis	cytoplasm|nucleus				breast(3)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(7)|lung(10)|ovary(1)|prostate(3)	35		all_cancers(63;0.0378)|Ovarian(32;0.000878)|all_epithelial(46;0.0162)|Breast(100;0.0164)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.022)|Epithelial(17;1.37e-11)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0443)		AACACTTTAAGAGAACGAATA	0.403000													8	22					0.0381472	0.0384265	1	1	0
TEAD4	7004	broad.mit.edu	37	12	3104133	3104133	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:3104133C>T	ENST00000359864.2	+	3	391	c.201C>T	c.(199-201)atC>atT	p.I67I	TEAD4_ENST00000397122.2_Intron|TEAD4_ENST00000358409.2_Silent_p.I67I	NM_003213.3	NP_003204	Q15561	TEAD4_HUMAN	TEA domain family member 4	67					hippo signaling cascade|muscle organ development|skeletal system development		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)	10	Ovarian(42;0.211)		OV - Ovarian serous cystadenocarcinoma(31;0.000563)|COAD - Colon adenocarcinoma(12;0.0831)			GCAAAATCATCCTGTCGGACG	0.612000													7	74					0	0	1	0	0
ARHGAP33	115703	broad.mit.edu	37	19	36279015	36279015	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:36279015C>G	ENST00000007510.4	+	21	3692	c.3548C>G	c.(3547-3549)tCt>tGt	p.S1183C	ARHGAP33_ENST00000378944.5_Missense_Mutation_p.S1019C|ARHGAP33_ENST00000314737.5_Missense_Mutation_p.S1022C			O14559	RHG33_HUMAN	Rho GTPase activating protein 33	1183	Poly-Ser.				cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			endometrium(7)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	37						TCACCTGCCTCTTCCTCCTCC	0.687000													12	43					0	0	1	0	0
CASC3	22794	broad.mit.edu	37	17	38320215	38320215	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr17:38320215G>A	ENST00000264645.7	+	7	1493	c.1267G>A	c.(1267-1269)Gag>Aag	p.E423K		NM_007359.4	NP_031385.2	O15234	CASC3_HUMAN	cancer susceptibility candidate 3	423	Necessary for localization in cytoplasmic stress granules.				mRNA processing|mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translation|response to stress|RNA splicing	exon-exon junction complex|nuclear speck|perinuclear region of cytoplasm	identical protein binding|RNA binding|ubiquitin protein ligase binding			endometrium(4)|kidney(2)|large_intestine(3)|lung(4)|ovary(1)|urinary_tract(2)	16						GCTTGCAGAGGAGGTGCCCCC	0.562000													17	28					0	0	1	0	0
SLC1A4	6509	broad.mit.edu	37	2	65243799	65243799	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:65243799C>T	ENST00000234256.3	+	5	1269	c.1026C>T	c.(1024-1026)acC>acT	p.T342T	SLC1A4_ENST00000531327.1_Intron	NM_003038.4	NP_003029.2	P43007	SATT_HUMAN	solute carrier family 1 (glutamate/neutral amino acid transporter), member 4	342					cellular nitrogen compound metabolic process|cognition|synaptic transmission, glutamatergic	intermediate filament|melanosome	chloride channel activity|L-alanine transmembrane transporter activity|L-cystine transmembrane transporter activity|L-hydroxyproline transmembrane transporter activity|L-proline transmembrane transporter activity|L-serine transmembrane transporter activity|L-threonine transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|pancreas(1)|prostate(1)|urinary_tract(1)	13					L-Alanine(DB00160)	CATTTGCTACCTGCTCCAGGT	0.488000													29	28					0	0	1	0	0
APC2	10297	broad.mit.edu	37	19	1466484	1466484	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:1466484G>C	ENST00000535453.1	+	14	4897	c.3184G>C	c.(3184-3186)Gag>Cag	p.E1062Q	APC2_ENST00000233607.2_Missense_Mutation_p.E1062Q|C19orf25_ENST00000588427.1_Intron|APC2_ENST00000238483.4_Missense_Mutation_p.E788Q			O95996	APC2_HUMAN	adenomatosis polyposis coli 2	1062	5 X 20 AA approximate repeat of F-X-V-E- X-T-P-X-C-F-S-R-X-S-S-L-S-S-L-S.|Interaction with CTNNB1.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|cervix(1)|kidney(4)|large_intestine(2)|lung(5)|pancreas(1)|skin(2)	18		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCGGCGCAAGAGGGGCCACT	0.687000													9	10					0	0	1	0	0
ADCY4	196883	broad.mit.edu	37	14	24802090	24802090	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr14:24802090C>T	ENST00000310677.4	-	3	377	c.264G>A	c.(262-264)tgG>tgA	p.W88*	ADCY4_ENST00000396747.3_5'UTR|ADCY4_ENST00000558563.1_5'UTR|RP11-934B9.3_ENST00000555591.1_Missense_Mutation_p.D155N|ADCY4_ENST00000554068.2_Nonsense_Mutation_p.W88*|ADCY4_ENST00000418030.2_Nonsense_Mutation_p.W88*	NM_001198568.1|NM_001198592.1|NM_139247.3	NP_001185497.1|NP_001185521.1|NP_640340.2	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	88					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(265;0.0192)		GGGGACGCGTCCAGCGCTGCA	0.692000											OREG0022624	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	13					0	0	1	0	0
NCAPH	23397	broad.mit.edu	37	2	97019974	97019974	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:97019974C>T	ENST00000455200.1	+	9	1318	c.1023C>T	c.(1021-1023)atC>atT	p.I341I	NCAPH_ENST00000240423.4_Silent_p.I352I|NCAPH_ENST00000427946.1_Silent_p.I216I			Q15003	CND2_HUMAN	non-SMC condensin I complex, subunit H	352					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|microtubule cytoskeleton|nucleus				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Ovarian(717;0.0221)				TATTTGACATCAATGCTGAAG	0.502000													18	138					0	0	1	0	0
MRPS31	10240	broad.mit.edu	37	13	41340884	41340884	+	Silent	SNP	C	C	T	rs35441585	byFrequency	TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr13:41340884C>T	ENST00000323563.6	-	2	474	c.438G>A	c.(436-438)aaG>aaA	p.K146K		NM_005830.3	NP_005821.2	Q92665	RT31_HUMAN	mitochondrial ribosomal protein S31	146						mitochondrion|ribosome	protein domain specific binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	13		Lung NSC(96;3.55e-06)|Breast(139;0.00394)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(188;0.194)		all cancers(112;1.52e-08)|Epithelial(112;7.63e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000192)|GBM - Glioblastoma multiforme(144;0.00233)|BRCA - Breast invasive adenocarcinoma(63;0.0706)		AAATTTACCTCTTCTTTGGAG	0.338000													13	19					0	0	1	0	0
OR4C16	219428	broad.mit.edu	37	11	55339744	55339744	+	Silent	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:55339744C>G	ENST00000314634.3	+	1	141	c.141C>G	c.(139-141)gtC>gtG	p.V47V		NM_001004701.2	NP_001004701.2	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C, member 16 (gene/pseudogene)	47					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(28)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41		all_epithelial(135;0.0748)				TTATTAGTGTCAAGACCAGCC	0.378000													43	101					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45262889	45262889	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr5:45262889G>T	ENST00000303230.4	-	8	1864	c.1807C>A	c.(1807-1809)Caa>Aaa	p.Q603K		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	603						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						TGGAACTTTTGCAGAAGAATT	0.433000													12	64					7.03913e-09	7.49025e-09	1	1	0
IGKJ4	28947	broad.mit.edu	37	2	89160422	89160422	+	RNA	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:89160422C>T	ENST00000452230.1	-	0	39				AC096579.7_ENST00000430694.1_RNA|IGKJ4_ENST00000390239.2_RNA																							TTGGTCCCTCCGCCGAAAGTG	0.418000													34	32					0	0	1	0	0
SNX31	169166	broad.mit.edu	37	8	101608942	101608942	+	Silent	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr8:101608942G>T	ENST00000311812.2	-	10	1053	c.903C>A	c.(901-903)atC>atA	p.I301I	SNX31_ENST00000428383.2_Silent_p.I202I	NM_152628.3	NP_689841.3	Q8N9S9	SNX31_HUMAN	sorting nexin 31	301					cell communication|protein transport		phosphatidylinositol binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|skin(3)|urinary_tract(1)	26	all_cancers(14;4.01e-05)|all_epithelial(15;1.26e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;1.21e-11)|all cancers(13;2.62e-09)|OV - Ovarian serous cystadenocarcinoma(57;3.22e-06)|STAD - Stomach adenocarcinoma(118;0.206)			CAGGCAGGGTGATGCAGCAGC	0.512000													38	41					2.6416e-12	2.85506e-12	1	1	0
CLECL1	160365	broad.mit.edu	37	12	9885610	9885610	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:9885610A>G	ENST00000327839.3	-	1	285	c.251T>C	c.(250-252)gTc>gCc	p.V84A		NM_172004.3	NP_742001.1	Q8IZS7	CLCL1_HUMAN	C-type lectin-like 1	84						integral to membrane|plasma membrane	sugar binding			breast(1)|kidney(1)|large_intestine(4)|lung(3)	9						GTCAGCGTAGACTACATCTCC	0.428000													11	52					0	0	1	0	0
ABCC5	10057	broad.mit.edu	37	3	183696419	183696419	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:183696419G>A	ENST00000334444.6	-	9	1408	c.1168C>T	c.(1168-1170)Cgg>Tgg	p.R390W	ABCC5_ENST00000265586.6_Missense_Mutation_p.R390W|ABCC5_ENST00000492216.1_5'UTR	NM_005688.2	NP_005679.2	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	390	ABC transmembrane type-1 1.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TCCAATATCCGACGCTCCTCC	0.473000													17	47					0	0	1	0	0
OVCH1	341350	broad.mit.edu	37	12	29608223	29608223	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:29608223C>G	ENST00000318184.5	-	20	2395	c.2396G>C	c.(2395-2397)aGa>aCa	p.R799T	OVCH1-AS1_ENST00000551108.1_Intron|OVCH1-AS1_ENST00000549411.1_Intron	NM_183378.2	NP_899234.2	Q7RTY7	OVCH1_HUMAN	ovochymase 1	799	Peptidase S1 2.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(43)|ovary(5)|pancreas(3)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)	92	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					GATCATCACTCTGGCAAATAC	0.423000													17	52					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38990358	38990358	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:38990358G>A	ENST00000355481.4	+	44	7242	c.7111G>A	c.(7111-7113)Gag>Aag	p.E2371K	RYR1_ENST00000360985.3_Missense_Mutation_p.E2371K|RYR1_ENST00000359596.3_Missense_Mutation_p.E2371K	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	2371	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CCTGCGGGGTGAGGGTGGCTC	0.701000													7	6					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110476838	110476838	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr8:110476838G>A	ENST00000378402.5	+	49	7881	c.7777G>A	c.(7777-7779)Gat>Aat	p.D2593N		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	2593					immune response	cytosol|extracellular space|integral to membrane	receptor activity	p.D2595H(1)		NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CAACCACCCTGATGGGCCATC	0.453000										HNSCC(38;0.096)			13	46					0	0	1	0	0
STK32B	55351	broad.mit.edu	37	4	5332959	5332959	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr4:5332959G>A	ENST00000282908.5	+	4	695	c.273G>A	c.(271-273)caG>caA	p.Q91Q	STK32B_ENST00000512636.1_Silent_p.Q44Q|STK32B_ENST00000510398.1_Silent_p.Q44Q	NM_018401.1	NP_060871.1	Q9NY57	ST32B_HUMAN	serine/threonine kinase 32B	91	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(16)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	39						ACTCCTTCCAGGATGAGGAGG	0.532000													14	36					0	0	1	0	0
LRRC57	255252	broad.mit.edu	37	15	42840305	42840305	+	Splice_Site	SNP	C	C	A	rs150825131		TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr15:42840305C>A	ENST00000323443.2	-	2	589	c.222G>T	c.(220-222)ctG>ctT	p.L74L	LRRC57_ENST00000563454.1_Splice_Site_p.L74L|LRRC57_ENST00000397130.3_Splice_Site_p.L74L			Q8N9N7	LRC57_HUMAN	leucine rich repeat containing 57	74										breast(1)|kidney(1)|lung(5)|prostate(1)	8		all_cancers(109;1.99e-12)|all_epithelial(112;5.11e-11)|Lung NSC(122;4.53e-07)|all_lung(180;1.64e-06)|Melanoma(134;0.0262)		GBM - Glioblastoma multiforme(94;6.87e-07)		GAGCCATACTCAGTTTGTTGT	0.468000													12	38					7.93312e-07	8.33107e-07	1	1	0
DDX19B	11269	broad.mit.edu	37	16	70349884	70349884	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr16:70349884C>T	ENST00000288071.6	+	4	418	c.173C>T	c.(172-174)gCc>gTc	p.A58V	DDX19B_ENST00000393657.2_5'UTR|RP11-529K1.3_ENST00000567706.1_Missense_Mutation_p.A58V|RP11-529K1.2_ENST00000562077.1_RNA|DDX19B_ENST00000355992.3_Missense_Mutation_p.A58V|DDX19B_ENST00000563206.1_Missense_Mutation_p.A63V|DDX19B_ENST00000570055.1_3'UTR|DDX19B_ENST00000568625.1_5'UTR|DDX19B_ENST00000563392.1_5'UTR|DDX19B_ENST00000451014.3_Missense_Mutation_p.A63V	NM_007242.5	NP_009173.1	Q9UMR2	DD19B_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B	58					mRNA export from nucleus|protein transport|transmembrane transport	cytoplasm|nuclear membrane|nuclear pore	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(1)|prostate(1)	9		Ovarian(137;0.0694)				GACAGAGCTGCCCAGTCCTTA	0.433000													42	123					0	0	1	0	0
ATXN1	6310	broad.mit.edu	37	6	16327614	16327614	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:16327614C>T	ENST00000244769.4	-	8	1864	c.928G>A	c.(928-930)Gag>Aag	p.E310K	ATXN1_ENST00000436367.1_Missense_Mutation_p.E310K	NM_000332.3	NP_000323.2	P54253	ATX1_HUMAN	ataxin 1	310					cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(11)|lung(12)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)	44	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				CGGCTGCTCTCAGCTTTCTTG	0.672000													8	51					0	0	1	0	0
EVC2	132884	broad.mit.edu	37	4	5664925	5664925	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr4:5664925C>T	ENST00000310917.2	-	9	1545	c.814G>A	c.(814-816)Gat>Aat	p.D272N	EVC2_ENST00000344408.5_Missense_Mutation_p.D352N|EVC2_ENST00000344938.1_Missense_Mutation_p.D352N	NM_001166136.1	NP_001159608.1	Q86UK5	LBN_HUMAN	Ellis van Creveld syndrome 2	352						integral to membrane				NS(2)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(32)|lung(28)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	81						TTCACGCCATCAGCTGAGGTG	0.463000													23	54					0	0	1	0	0
DDR1	780	broad.mit.edu	37	6	30863264	30863264	+	Missense_Mutation	SNP	G	G	A	rs138565451		TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:30863264G>A	ENST00000324771.8	+	14	2145	c.1597G>A	c.(1597-1599)Gcc>Acc	p.A533T	DDR1_ENST00000446312.1_Intron|DDR1_ENST00000376575.3_Missense_Mutation_p.A533T|DDR1_ENST00000376567.2_Intron|DDR1_ENST00000452441.1_Missense_Mutation_p.A533T|DDR1_ENST00000376569.3_Intron|DDR1_ENST00000361741.4_Silent_p.P236P|DDR1_ENST00000513240.1_Missense_Mutation_p.A533T|DDR1_ENST00000418800.2_Intron|DDR1_ENST00000376570.4_Intron|DDR1_ENST00000454612.2_Intron|DDR1_ENST00000508312.1_Intron|DDR1_ENST00000376568.3_Missense_Mutation_p.A533T			Q08345	DDR1_HUMAN	discoidin domain receptor tyrosine kinase 1	533	Gly/Pro-rich.				cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(14)|ovary(1)|prostate(1)|skin(1)	29					Imatinib(DB00619)	CCCCACACCCGCCTGGGCCAA	0.682000													24	68					0	0	1	0	0
TSKU	25987	broad.mit.edu	37	11	76507390	76507390	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:76507390G>A	ENST00000527881.1	+	2	1756	c.730G>A	c.(730-732)Gag>Aag	p.E244K	TSKU_ENST00000333090.4_Missense_Mutation_p.E244K			Q8WUA8	TSK_HUMAN	tsukushi, small leucine rich proteoglycan	244						extracellular region				NS(1)|large_intestine(4)|lung(6)|urinary_tract(1)	12	Ovarian(111;0.112)					GAGGCTCCCTGAGCTGGCGCC	0.647000													30	77					0	0	1	0	0
ZBP1	81030	broad.mit.edu	37	20	56179691	56179691	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr20:56179691C>G	ENST00000340462.4	-	7	1439	c.1159G>C	c.(1159-1161)Gaa>Caa	p.E387Q	ZBP1_ENST00000371173.3_Missense_Mutation_p.E410Q|ZBP1_ENST00000395822.3_Missense_Mutation_p.E335Q			Q9H171	ZBP1_HUMAN	Z-DNA binding protein 1	410						cytoplasm|nucleus	double-stranded RNA adenosine deaminase activity|left-handed Z-DNA binding|RNA binding			large_intestine(11)|lung(8)|ovary(4)|prostate(1)|skin(2)|urinary_tract(1)	27	Lung NSC(12;0.000545)|all_lung(29;0.00195)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;7.87e-13)|Epithelial(14;3.26e-09)|all cancers(14;3.62e-08)			TGGCTGCCTTCTGCAGCTTTG	0.577000													21	38					0	0	1	0	0
TXN2	25828	broad.mit.edu	37	22	36872861	36872861	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr22:36872861C>G	ENST00000216185.2	-	3	772	c.306G>C	c.(304-306)aaG>aaC	p.K102N	TXN2_ENST00000416967.1_5'UTR|TXN2_ENST00000403313.1_Missense_Mutation_p.K102N|TXN2_ENST00000487725.1_5'UTR			Q99757	THIOM_HUMAN	thioredoxin 2	102	Thioredoxin.				cell redox homeostasis|electron transport chain|glycerol ether metabolic process|transport	mitochondrion|nucleolus	electron carrier activity			breast(1)|lung(1)|prostate(1)	3						TGGCCACCATCTTCTCTAACC	0.542000													11	73					0	0	1	0	0
PRB1	5542	broad.mit.edu	37	12	11506247	11506247	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:11506247G>A	ENST00000500254.2	-	4	428	c.391C>T	c.(391-393)Ccc>Tcc	p.P131S	PRB1_ENST00000545626.1_Missense_Mutation_p.P111S|PRB1_ENST00000546254.1_Missense_Mutation_p.P131S	NM_005039.3|NM_199353.2	NP_005030.2|NP_955385.1	P04280	PRP1_HUMAN	proline-rich protein BstNI subfamily 1	325	15 X 20 AA approximate tandem repeats of P-P-G-K-P-Q-G-P-P-[PAQ]-Q-[GE]-[GD]- [NKS]-[KSQRN]-[PRQS]-[QS] [GPS]-[PQAR]- [PSR].		Missing (in allele M).|Missing (in clone CP-4).|Missing (in clone CP-5).			extracellular region				NS(1)|central_nervous_system(1)|kidney(4)|large_intestine(1)|lung(9)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	20			OV - Ovarian serous cystadenocarcinoma(49;0.185)			CCTTGTGCGGGTGGTCCTTGT	0.602000													24	113					0	0	1	0	0
TBCD	6904	broad.mit.edu	37	17	80890597	80890597	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr17:80890597C>G	ENST00000355528.4	+	34	3307	c.3177C>G	c.(3175-3177)ttC>ttG	p.F1059L	TBCD_ENST00000539345.2_Missense_Mutation_p.F1059L	NM_005993.4	NP_005984.3	Q9BTW9	TBCD_HUMAN	tubulin folding cofactor D	1059					'de novo' posttranslational protein folding|adherens junction assembly|negative regulation of cell-substrate adhesion|negative regulation of microtubule polymerization|post-chaperonin tubulin folding pathway|tight junction assembly	adherens junction|cytoplasm|lateral plasma membrane|microtubule|tight junction	beta-tubulin binding|chaperone binding|GTPase activator activity					Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0266)|all_epithelial(8;0.0696)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.18)			TCGACATCTTCACCACGGAGG	0.532000													11	47					0	0	1	0	0
KANK4	163782	broad.mit.edu	37	1	62728893	62728893	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:62728893C>T	ENST00000371153.4	-	7	2788	c.2410G>A	c.(2410-2412)Gag>Aag	p.E804K	KANK4_ENST00000317477.4_5'UTR|KANK4_ENST00000371150.1_Missense_Mutation_p.E160K|KANK4_ENST00000354381.3_Missense_Mutation_p.E176K	NM_181712.4	NP_859063.3	Q5T7N3	KANK4_HUMAN	KN motif and ankyrin repeat domains 4	804										NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(49)|ovary(3)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	81						GGCTGGACCTCGTGGAGGTAG	0.587000													7	20					0	0	1	0	0
EFNA4	1945	broad.mit.edu	37	1	155039418	155039418	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:155039418C>T	ENST00000368409.3	+	2	419	c.326C>T	c.(325-327)tCa>tTa	p.S109L	EFNA3_ENST00000556931.1_Intron|EFNA3_ENST00000505139.1_Intron|EFNA4_ENST00000427683.2_Missense_Mutation_p.S109L|EFNA4_ENST00000359751.4_Missense_Mutation_p.S109L	NM_005227.2	NP_005218.1			ephrin-A4											breast(1)|endometrium(1)|large_intestine(1)|ovary(1)	4	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			GTTCAATTCTCAGAGAAGATT	0.567000													27	86					0	0	1	0	0
ZNF155	7711	broad.mit.edu	37	19	44501429	44501429	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:44501429C>T	ENST00000270014.2	+	5	1548	c.1420C>T	c.(1420-1422)Cat>Tat	p.H474Y	ZNF155_ENST00000407951.2_Missense_Mutation_p.H485Y|ZNF155_ENST00000590615.1_Missense_Mutation_p.H474Y|RP11-15A1.7_ENST00000589021.1_RNA|RP11-15A1.7_ENST00000586860.1_RNA	NM_001260487.1|NM_198089.2	NP_001247416|NP_932355	Q12901	ZN155_HUMAN	zinc finger protein 155	474			H -> R (in a colorectal cancer sample; somatic mutation).			nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(2)	15		Prostate(69;0.0352)				TATTTTGAATCATAAGAGACT	0.448000													54	88					0	0	1	0	0
MEP1A	4224	broad.mit.edu	37	6	46801206	46801206	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:46801206G>A	ENST00000230588.4	+	11	1549	c.1540G>A	c.(1540-1542)Gag>Aag	p.E514K		NM_005588.2	NP_005579.2	Q16819	MEP1A_HUMAN	meprin A, alpha (PABA peptide hydrolase)	514	MATH.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42			Lung(136;0.192)			CCTTGACCAGGAGCCTGATGT	0.507000													19	101					0	0	1	0	0
TOP3B	8940	broad.mit.edu	37	22	22317255	22317255	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr22:22317255C>T	ENST00000398793.2	-	12	1649	c.1215G>A	c.(1213-1215)gcG>gcA	p.A405A	TOP3B_ENST00000357179.5_Silent_p.A405A|TOP3B_ENST00000413067.2_Silent_p.A134A	NM_003935.3	NP_003926.1	O95985	TOP3B_HUMAN	topoisomerase (DNA) III beta	405					DNA topological change	nucleus	ATP binding|DNA topoisomerase type I activity|protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(4)|lung(9)|ovary(1)	26	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.145)		AGAGCCGCCACGCGTCACCCC	0.622000													8	33					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51174590	51174590	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr16:51174590C>G	ENST00000440970.1	-	2	1683	c.1252G>C	c.(1252-1254)Gag>Cag	p.E418Q	SALL1_ENST00000251020.4_Missense_Mutation_p.E515Q|SALL1_ENST00000541611.1_Intron|SALL1_ENST00000566102.1_Intron	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	515					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			TCCAAATGCTCAGGCACAGGA	0.522000													19	47					0	0	1	0	0
NUP214	8021	broad.mit.edu	37	9	134027165	134027165	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr9:134027165G>C	ENST00000359428.5	+	17	2464	c.2320G>C	c.(2320-2322)Gag>Cag	p.E774Q	RP11-544A12.4_ENST00000415391.2_RNA|RP11-544A12.4_ENST00000587408.1_RNA|NUP214_ENST00000451030.1_Missense_Mutation_p.E775Q|RP11-544A12.4_ENST00000590461.1_RNA|RP11-544A12.4_ENST00000586290.1_RNA|RP11-544A12.4_ENST00000589667.1_RNA|RP11-544A12.4_ENST00000589540.1_RNA|RP11-544A12.4_ENST00000587264.1_RNA|RP11-544A12.4_ENST00000588378.1_RNA|NUP214_ENST00000411637.2_Missense_Mutation_p.E764Q			P35658	NU214_HUMAN	nucleoporin 214kDa	774	11 X 5 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			NS(1)|breast(9)|central_nervous_system(3)|endometrium(13)|kidney(2)|large_intestine(9)|liver(2)|lung(29)|ovary(2)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	86	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		AACTTTACTTGAGGGCTTTGC	0.383000			T	"""DEK, SET, ABL1"""	"""AML, T-ALL"""								18	52					0	0	1	0	0
FAM214A	56204	broad.mit.edu	37	15	52903368	52903368	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr15:52903368C>T	ENST00000261844.7	-	5	641	c.489G>A	c.(487-489)ctG>ctA	p.L163L	FAM214A_ENST00000546305.2_Silent_p.L170L	NM_019600.2	NP_062546.2	Q32MH5	K1370_HUMAN	family with sequence similarity 214, member A	163																	GAGAAACACTCAGCCATGCAC	0.428000													19	40					0	0	1	0	0
REXO4	57109	broad.mit.edu	37	9	136279826	136279826	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr9:136279826C>A	ENST00000371942.3	-	2	730	c.531G>T	c.(529-531)aaG>aaT	p.K177N	ADAMTS13_ENST00000485925.1_Intron|REXO4_ENST00000371935.2_Missense_Mutation_p.R118I|REXO4_ENST00000478037.1_5'UTR	NM_020385.2	NP_065118.2	Q9GZR2	REXO4_HUMAN	REX4, RNA exonuclease 4 homolog (S. cerevisiae)	177						nucleolus	exonuclease activity|nucleic acid binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(4)|lung(7)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	15				OV - Ovarian serous cystadenocarcinoma(145;8.58e-08)|Epithelial(140;9.55e-07)|all cancers(34;1.05e-05)		CTTTCCGCTTCTTATGCTCGA	0.542000													16	50					0.0285812	0.0288811	1	1	0
TRAV26-2	28656	broad.mit.edu	37	14	22671077	22671077	+	RNA	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr14:22671077G>C	ENST00000390460.1	+	0	142																											CAGTGGAACTGATTACATACA	0.453000													9	24					0	0	1	0	0
MPL	4352	broad.mit.edu	37	1	43805747	43805747	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:43805747C>G	ENST00000372470.3	+	5	845	c.803C>G	c.(802-804)tCc>tGc	p.S268C	MPL_ENST00000413998.2_Missense_Mutation_p.S268C	NM_005373.2	NP_005364.1	P40238	TPOR_HUMAN	myeloproliferative leukemia virus oncogene	268					cell proliferation|platelet activation	integral to plasma membrane	cytokine receptor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(551)|large_intestine(3)|lung(7)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	567	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CTCGGTGGCTCCTGGGGATCC	0.577000			Mis		MPD	MPD	congenital amegakaryocytic thrombocytopenia						3	16					0	0	1	0	0
ELAVL2	1993	broad.mit.edu	37	9	23692861	23692861	+	Missense_Mutation	SNP	G	G	C	rs138657080	by1000genomes	TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr9:23692861G>C	ENST00000397312.2	-	7	1048	c.774C>G	c.(772-774)gaC>gaG	p.D258E	ELAVL2_ENST00000544538.1_Missense_Mutation_p.D258E|ELAVL2_ENST00000380110.4_Missense_Mutation_p.D288E|ELAVL2_ENST00000223951.6_Missense_Mutation_p.D245E|ELAVL2_ENST00000380117.1_Missense_Mutation_p.D258E	NM_004432.3	NP_004423.2	Q12926	ELAV2_HUMAN	ELAV like neuron-specific RNA binding protein 2	258					regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	39				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)		TGGTCATTCCGTCAATGGTCA	0.423000													3	37					0	0	1	0	0
PIPOX	51268	broad.mit.edu	37	17	27370262	27370262	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr17:27370262C>A	ENST00000323372.4	+	1	345	c.19C>A	c.(19-21)Ctc>Atc	p.L7I	PIPOX_ENST00000583215.1_Intron	NM_016518.2	NP_057602.2	Q9P0Z9	SOX_HUMAN	pipecolic acid oxidase	7					tetrahydrofolate metabolic process	peroxisome	L-pipecolate oxidase activity|sarcosine oxidase activity			endometrium(2)|large_intestine(4)|lung(1)|prostate(1)|skin(1)|urinary_tract(1)	10	Lung NSC(42;0.015)		Epithelial(11;9.87e-06)|BRCA - Breast invasive adenocarcinoma(11;3.92e-05)|all cancers(11;5.59e-05)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)		Glycine(DB00145)	TCAGAAAGATCTCTGGGACGC	0.582000													9	38					0.00448238	0.00458718	1	1	0
FAM208B	54906	broad.mit.edu	37	10	5790587	5790587	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr10:5790587G>C	ENST00000328090.5	+	15	5828	c.5203G>C	c.(5203-5205)Gat>Cat	p.D1735H		NM_017782.4	NP_060252	Q5VWN6	CJ018_HUMAN	family with sequence similarity 208, member B	1735																	CACGCTGCAAGATGTGTCAAC	0.483000													25	21					0	0	1	0	0
ST13	6767	broad.mit.edu	37	22	41228587	41228587	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr22:41228587C>A	ENST00000216218.3	-	8	1148	c.667G>T	c.(667-669)Gaa>Taa	p.E223*		NM_003932.3	NP_003923.2	P50502	F10A1_HUMAN	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)	223							protein binding, bridging			cervix(1)|large_intestine(1)|lung(3)|skin(1)	6						GGTTGAACTTCTTTCAGCATT	0.433000													5	37					0.014758	0.0149599	1	1	0
NRAP	4892	broad.mit.edu	37	10	115405671	115405671	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr10:115405671C>T	ENST00000369358.4	-	11	1267	c.1023G>A	c.(1021-1023)atG>atA	p.M341I	NRAP_ENST00000360478.3_Missense_Mutation_p.M341I|NRAP_ENST00000369360.3_Missense_Mutation_p.M341I|NRAP_ENST00000359988.3_Missense_Mutation_p.M341I			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	341						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		CAGCGCCTTTCATCTTATTGA	0.458000													25	44					0	0	1	0	0
CYP3A7	1551	broad.mit.edu	37	7	99312292	99312292	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:99312292G>T	ENST00000336374.2	-	8	686	c.684C>A	c.(682-684)ttC>ttA	p.F228L		NM_000765.3	NP_000756.2	P24462	CP3A7_HUMAN	cytochrome P450, family 3, subfamily A, polypeptide 7	228					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			autonomic_ganglia(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	32	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)					TTGGGGTAAGGAATGGAAAGA	0.318000													16	51					5.03518e-11	5.40567e-11	1	1	0
ANKAR	150709	broad.mit.edu	37	2	190611323	190611323	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:190611323G>A	ENST00000520309.1	+	23	4363	c.4275G>A	c.(4273-4275)caG>caA	p.Q1425Q	ANKAR_ENST00000281412.6_3'UTR|ANKAR_ENST00000438402.2_3'UTR|ANKAR_ENST00000313581.4_Silent_p.Q1425Q|ANKAR_ENST00000431575.2_Silent_p.Q1354Q	NM_144708.3	NP_653309.3	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	1425						integral to membrane	binding			breast(3)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(16)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(2)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			AACATGTCCAGAAAGCCAACC	0.313000													22	27					0	0	1	0	0
TRPM3	80036	broad.mit.edu	37	9	73477919	73477919	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr9:73477919C>G	ENST00000377110.3	-	3	610	c.367G>C	c.(367-369)Gaa>Caa	p.E123Q	TRPM3_ENST00000377097.3_5'UTR|TRPM3_ENST00000423814.3_Missense_Mutation_p.E125Q|TRPM3_ENST00000360823.2_5'UTR|TRPM3_ENST00000377106.1_5'UTR|TRPM3_ENST00000396283.1_5'UTR|TRPM3_ENST00000377111.2_Missense_Mutation_p.E123Q|TRPM3_ENST00000361823.5_5'UTR|TRPM3_ENST00000357533.2_Missense_Mutation_p.E125Q|TRPM3_ENST00000377101.1_5'UTR|TRPM3_ENST00000437699.3_5'UTR|TRPM3_ENST00000377105.1_5'UTR			Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3							integral to membrane	calcium channel activity			NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						GACCACTTTTCAGACTGGATG	0.502000													14	35					0	0	1	0	0
PKD1L1	168507	broad.mit.edu	37	7	47898429	47898429	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:47898429G>C	ENST00000289672.2	-	27	4254	c.4204C>G	c.(4204-4206)Caa>Gaa	p.Q1402E		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	1402	REJ.				cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						AACTGGCCTTGAGCAAGGAGT	0.488000													6	37					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114276415	114276415	+	Missense_Mutation	SNP	C	C	T	rs143469039		TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr4:114276415C>T	ENST00000357077.4	+	38	6694	c.6641C>T	c.(6640-6642)cCg>cTg	p.P2214L	ANK2_ENST00000510275.2_Intron|ANK2_ENST00000264366.6_Missense_Mutation_p.P2181L|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000509550.1_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2181					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GCCGGCTCTCCGTGTGGCAGC	0.512000													9	35					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29120968	29120968	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr22:29120968T>G	ENST00000382580.2	-	5	793	c.718A>C	c.(718-720)Aaa>Caa	p.K240Q	CHEK2_ENST00000328354.6_Missense_Mutation_p.K197Q|CHEK2_ENST00000403642.1_Intron|CHEK2_ENST00000405598.1_Missense_Mutation_p.K197Q|CHEK2_ENST00000404276.1_Missense_Mutation_p.K197Q|CHEK2_ENST00000382578.1_Intron|CHEK2_ENST00000382566.1_Missense_Mutation_p.K197Q|CHEK2_ENST00000348295.3_Missense_Mutation_p.K197Q|CHEK2_ENST00000544772.1_5'UTR|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000402731.1_Missense_Mutation_p.K197Q	NM_001005735.1	NP_001005735.1	O96017	CHK2_HUMAN	checkpoint kinase 2	197	Protein kinase.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						ATATTACCTTTATTTCTGCTT	0.353000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					18	24					0	0	1	0	0
CHD2	1106	broad.mit.edu	37	15	93557924	93557924	+	Splice_Site	SNP	A	A	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr15:93557924A>T	ENST00000394196.4	+	37	5760		c.e37-1		CHD2_ENST00000557381.1_Splice_Site	NM_001271.3	NP_001262.3	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2						regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	47	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			TTTACTCTTTAGGAGCAAAAG	0.473000													9	30					0	0	1	0	0
SNX31	169166	broad.mit.edu	37	8	101601189	101601189	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr8:101601189C>T	ENST00000311812.2	-	11	1147	c.997G>A	c.(997-999)Gat>Aat	p.D333N	SNX31_ENST00000428383.2_Missense_Mutation_p.D234N|SNX31_ENST00000519521.1_5'UTR	NM_152628.3	NP_689841.3	Q8N9S9	SNX31_HUMAN	sorting nexin 31	333					cell communication|protein transport		phosphatidylinositol binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|skin(3)|urinary_tract(1)	26	all_cancers(14;4.01e-05)|all_epithelial(15;1.26e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;1.21e-11)|all cancers(13;2.62e-09)|OV - Ovarian serous cystadenocarcinoma(57;3.22e-06)|STAD - Stomach adenocarcinoma(118;0.206)			TGGGGCCCATCCGTATCCAGC	0.423000													26	34					0	0	1	0	0
BPTF	2186	broad.mit.edu	37	17	65914842	65914842	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr17:65914842G>A	ENST00000321892.4	+	14	5755	c.5694G>A	c.(5692-5694)caG>caA	p.Q1898Q	BPTF_ENST00000424123.3_Silent_p.Q1759Q|BPTF_ENST00000306378.6_Silent_p.Q1772Q|BPTF_ENST00000335221.5_Silent_p.Q1898Q			Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	1898					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding	p.Q1898H(1)|p.Q1772H(1)		NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(23)|ovary(3)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	78	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			ATAGACTTCAGACAGTAAAGT	0.423000													17	70					0	0	1	0	0
TEX11	56159	broad.mit.edu	37	X	69871318	69871318	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:69871318C>G	ENST00000395889.2	-	18	1665	c.1510G>C	c.(1510-1512)Gag>Cag	p.E504Q	TEX11_ENST00000344304.3_Missense_Mutation_p.E504Q|TEX11_ENST00000374320.2_Missense_Mutation_p.E179Q|TEX11_ENST00000374333.2_Missense_Mutation_p.E489Q	NM_001003811.1	NP_001003811.1	Q8IYF3	TEX11_HUMAN	testis expressed 11	504							protein binding			breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(12)|lung(13)|ovary(3)|prostate(3)|skin(3)	48	Renal(35;0.156)					GAGTTGCCCTCTATGACTGCA	0.358000													13	17					0	0	1	0	0
RPL7	6129	broad.mit.edu	37	8	74204023	74204023	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr8:74204023G>A	ENST00000396467.1	-	4	431	c.293C>T	c.(292-294)cCa>cTa	p.P98L	RPL7_ENST00000352983.2_Missense_Mutation_p.P138L|RPL7_ENST00000396465.1_Missense_Mutation_p.P98L|RPL7_ENST00000396466.1_Missense_Mutation_p.P98L	NM_000971.3	NP_000962.2	P18124	RL7_HUMAN	ribosomal protein L7	138					endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	DNA binding|mRNA binding|protein homodimerization activity|structural constituent of ribosome			breast(1)|kidney(1)|large_intestine(2)|lung(1)	5	Breast(64;0.0954)		Epithelial(68;0.0193)|all cancers(69;0.0766)|BRCA - Breast invasive adenocarcinoma(89;0.134)			TGCAATATATGGCTCTACAAT	0.388000													17	87					0	0	1	0	0
ZCCHC13	389874	broad.mit.edu	37	X	73524385	73524385	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:73524385G>C	ENST00000339534.2	+	1	361	c.284G>C	c.(283-285)gGc>gCc	p.G95A		NM_203303.2	NP_976048.1	Q8WW36	ZCH13_HUMAN	zinc finger, CCHC domain containing 13	95							nucleic acid binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(1)|lung(4)|upper_aerodigestive_tract(1)	8						TATACCTGCGGCAGACTAGGA	0.517000													10	36					0	0	1	0	0
TRMT12	55039	broad.mit.edu	37	8	125463496	125463496	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr8:125463496G>C	ENST00000328599.3	+	1	449	c.328G>C	c.(328-330)Gag>Cag	p.E110Q	TRMT12_ENST00000521443.1_3'UTR	NM_017956.3	NP_060426.2	Q53H54	TYW2_HUMAN	tRNA methyltransferase 12 homolog (S. cerevisiae)	110					tRNA processing		methyltransferase activity			breast(2)|endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	15	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			ATTGTGTCTTGAGGTGAGTCG	0.577000													24	36					0	0	1	0	0
HIST1H4L	8368	broad.mit.edu	37	6	27840978	27840978	+	Nonstop_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:27840978C>G	ENST00000355981.2	-	1	311	c.311G>C	c.(310-312)tGa>tCa	p.*104S		NM_003546.2	NP_003537.1	P62805	H4_HUMAN	histone cluster 1, H4l	0					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	13						GTAAAACACTCAGCCGCCAAA	0.512000													11	24					0	0	1	0	0
ANKRD30BP2	149992	broad.mit.edu	37	21	14414844	14414844	+	RNA	SNP	T	T	C	rs148060711	by1000genomes	TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr21:14414844T>C	ENST00000507941.1	+	0	95																											ACTGGGCCTGTGCCAATGGCC	0.433000													4	47					0	0	1	0	0
PALMD	54873	broad.mit.edu	37	1	100155161	100155161	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:100155161G>A	ENST00000263174.4	+	7	1720	c.1345G>A	c.(1345-1347)Gat>Aat	p.D449N	PALMD_ENST00000605497.1_Missense_Mutation_p.D449N	NM_017734.4	NP_060204.1	Q9NP74	PALMD_HUMAN	palmdelphin	449					regulation of cell shape	cytoplasm|membrane				central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(8)|ovary(6)|pancreas(1)|prostate(2)	31		all_epithelial(167;0.000813)|all_lung(203;0.0214)|Lung NSC(277;0.0216)		Epithelial(280;0.067)|all cancers(265;0.117)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)		TGTGATTGATGATGAGGAGGA	0.493000													8	40					0	0	1	0	0
C2orf80	389073	broad.mit.edu	37	2	209045482	209045482	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:209045482G>A	ENST00000341287.4	-	6	548	c.353C>T	c.(352-354)tCt>tTt	p.S118F	C2orf80_ENST00000453017.1_Missense_Mutation_p.S118F|C2orf80_ENST00000451346.1_Missense_Mutation_p.S99F	NM_001099334.2	NP_001092804	Q0P641	CB080_HUMAN	chromosome 2 open reading frame 80	118										endometrium(2)|large_intestine(3)|lung(6)|skin(2)	13						GATGGTACCAGAATCGGCAGA	0.343000													19	52					0	0	1	0	0
RAB33A	9363	broad.mit.edu	37	X	129318670	129318670	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:129318670G>C	ENST00000257017.4	+	2	1084	c.670G>C	c.(670-672)Gag>Cag	p.E224Q		NM_004794.2	NP_004785.1	Q14088	RB33A_HUMAN	RAB33A, member RAS oncogene family	224					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(5)	11						GCAGAAACTGGAGTTCCCACA	0.443000													12	29					0	0	1	0	0
GDPD4	220032	broad.mit.edu	37	11	76944218	76944218	+	Splice_Site	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:76944218C>G	ENST00000315938.4	-	13	1492		c.e13-1		GDPD4_ENST00000376217.2_Splice_Site	NM_182833.1	NP_878253.1	Q6W3E5	GDPD4_HUMAN	glycerophosphodiester phosphodiesterase domain containing 4						glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|prostate(1)|skin(1)	20						TTTATAATCTCTGGAACAAAA	0.428000													13	53					0	0	1	0	0
SGIP1	84251	broad.mit.edu	37	1	67147569	67147569	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:67147569A>G	ENST00000371037.4	+	15	909	c.832A>G	c.(832-834)Aca>Gca	p.T278A	SGIP1_ENST00000237247.6_Missense_Mutation_p.T282A|SGIP1_ENST00000371039.1_Intron|SGIP1_ENST00000371036.3_Intron|SGIP1_ENST00000371035.3_Intron	NM_032291.2	NP_115667.2	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting protein 1	278	Pro-rich.				positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(43)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	71						CCAGTCAGCCACAGAGGTCAA	0.403000													7	138					0	0	1	0	0
GUCY2F	2986	broad.mit.edu	37	X	108684645	108684645	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:108684645G>A	ENST00000218006.2	-	7	1927	c.1636C>T	c.(1636-1638)Ctc>Ttc	p.L546F		NM_001522.2	NP_001513.2	P51841	GUC2F_HUMAN	guanylate cyclase 2F, retinal	546	Protein kinase.				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(6)|large_intestine(14)|lung(33)|prostate(3)|skin(1)	67						GAAAAGGAGAGTCTTGGGGAC	0.433000													5	196					0	0	1	0	0
OR2L13	284521	broad.mit.edu	37	1	248263103	248263103	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:248263103G>A	ENST00000366478.2	+	3	763	c.426G>A	c.(424-426)aaG>aaA	p.K142K	OR2L13_ENST00000358120.2_Silent_p.K142K	NM_175911.2	NP_787107.1	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L, member 13	142					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(32)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	59	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			TGTGTGTGAAGATGATTGGAG	0.488000													64	135					0	0	1	0	0
KCNJ4	3761	broad.mit.edu	37	22	38824093	38824093	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr22:38824093C>T	ENST00000303592.3	-	2	303	c.45G>A	c.(43-45)cgG>cgA	p.R15R		NM_004981.1|NM_152868.2	NP_004972.1|NP_690607.1	P48050	IRK4_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 4	15					synaptic transmission	basolateral plasma membrane|voltage-gated potassium channel complex	inward rectifier potassium channel activity|PDZ domain binding			endometrium(7)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	23	Melanoma(58;0.0286)					TGCGGCGCTTCCGCCGGGGCA	0.642000													41	207					0	0	1	0	0
AMPH	273	broad.mit.edu	37	7	38457532	38457532	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:38457532G>A	ENST00000356264.2	-	17	1506	c.1291C>T	c.(1291-1293)Cca>Tca	p.P431S	AMPH_ENST00000325590.5_Intron|AMPH_ENST00000471913.1_Intron|AMPH_ENST00000428293.2_Intron	NM_001635.3	NP_001626.1	P49418	AMPH_HUMAN	amphiphysin	431					endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(12)|liver(3)|lung(27)|ovary(3)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)	62						TCTGTGGGTGGAGCCTGTTCA	0.488000													17	61					0	0	1	0	0
MAPK15	225689	broad.mit.edu	37	8	144803408	144803408	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr8:144803408T>C	ENST00000338033.4	+	11	1150	c.1031T>C	c.(1030-1032)cTg>cCg	p.L344P		NM_139021.2	NP_620590.2	Q8TD08	MK15_HUMAN	mitogen-activated protein kinase 15	344					protein autophosphorylation	extracellular region	ATP binding|MAP kinase activity|SH3 domain binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|skin(1)|stomach(1)	12	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CAGATGATCCTGGAGTGTGGA	0.647000													11	50					0	0	1	0	0
KIAA2022	340533	broad.mit.edu	37	X	73962016	73962016	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:73962016G>T	ENST00000055682.6	-	3	2987	c.2376C>A	c.(2374-2376)tgC>tgA	p.C792*		NM_001008537.2	NP_001008537.1	Q5QGS0	K2022_HUMAN	KIAA2022						base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						TTTCAGAAGAGCATGTCGTTG	0.408000													25	85					2.49675e-24	2.77962e-24	1	1	0
ARHGAP33	115703	broad.mit.edu	37	19	36279068	36279068	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:36279068C>A	ENST00000007510.4	+	21	3745	c.3601C>A	c.(3601-3603)Ccc>Acc	p.P1201T	ARHGAP33_ENST00000378944.5_Missense_Mutation_p.P1037T|ARHGAP33_ENST00000314737.5_Missense_Mutation_p.P1040T			O14559	RHG33_HUMAN	Rho GTPase activating protein 33	1201					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			endometrium(7)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	37						AGATCCCGGTCCCCCAGTCCC	0.682000													11	39					2.27111e-07	2.39287e-07	1	1	0
EIF2AK3	9451	broad.mit.edu	37	2	88890561	88890561	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:88890561G>C	ENST00000303236.3	-	5	1078	c.777C>G	c.(775-777)ttC>ttG	p.F259L	EIF2AK3_ENST00000419748.1_Missense_Mutation_p.F108L	NM_004836.5	NP_004827.4	Q9NZJ5	E2AK3_HUMAN	eukaryotic translation initiation factor 2-alpha kinase 3	259					activation of caspase activity|bone mineralization|calcium-mediated signaling|chondrocyte development|endocrine pancreas development|endoplasmic reticulum organization|endoplasmic reticulum unfolded protein response|ER overload response|insulin secretion|insulin-like growth factor receptor signaling pathway|negative regulation of myelination|negative regulation of translational initiation in response to stress|protein autophosphorylation|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|identical protein binding			ovary(3)	3						GGCCAACACTGAAATTCCACC	0.348000													30	38					0	0	1	0	0
PADI6	353238	broad.mit.edu	37	1	17708559	17708559	+	RNA	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:17708559G>C	ENST00000434762.2	+	0	701							Q6TGC4	PADI6_HUMAN	peptidyl arginine deiminase, type VI						peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(2)	29		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;7.59e-06)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.0134)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	AGGAAGAGTCGAAGAAGGCGA	0.522000													23	54					0	0	1	0	0
ZNF44	51710	broad.mit.edu	37	19	12384228	12384228	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:12384228T>C	ENST00000356109.5	-	5	1104	c.986A>G	c.(985-987)tAc>tGc	p.Y329C	ZNF44_ENST00000355684.5_Missense_Mutation_p.Y281C	NM_001164276.1	NP_001157748.1	P15621	ZNF44_HUMAN	zinc finger protein 44	329					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1		Renal(1328;0.157)		GBM - Glioblastoma multiforme(1328;0.0164)|Lung(535;0.179)		TTTACATTTGTAGGGTTTCTC	0.413000													42	112					0	0	1	0	0
OVCH1	341350	broad.mit.edu	37	12	29592300	29592300	+	Silent	SNP	A	A	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:29592300A>G	ENST00000318184.5	-	26	3224	c.3225T>C	c.(3223-3225)ttT>ttC	p.F1075F	OVCH1-AS1_ENST00000551108.1_Intron|OVCH1-AS1_ENST00000549411.1_Intron	NM_183378.2	NP_899234.2	Q7RTY7	OVCH1_HUMAN	ovochymase 1	1075					proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(43)|ovary(5)|pancreas(3)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)	92	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					atgtgttaataaaattcagtt	0.318000													15	16					0	0	1	0	0
RNF168	165918	broad.mit.edu	37	3	196198865	196198865	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:196198865G>C	ENST00000318037.3	-	6	2135	c.1541C>G	c.(1540-1542)tCa>tGa	p.S514*		NM_152617.3	NP_689830.2	Q8IYW5	RN168_HUMAN	ring finger protein 168, E3 ubiquitin protein ligase	514					double-strand break repair|histone H2A K63-linked ubiquitination|positive regulation of DNA repair|response to ionizing radiation	nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|endometrium(2)|large_intestine(7)|lung(9)|ovary(1)	20	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;5.25e-24)|all cancers(36;5.47e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00348)		TTTGTCCCTTGAGCCTCTCTC	0.423000													138	174					0	0	1	0	0
FTSJ3	117246	broad.mit.edu	37	17	61904001	61904001	+	Silent	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr17:61904001G>T	ENST00000427159.2	-	3	744	c.99C>A	c.(97-99)atC>atA	p.I33I		NM_017647.3	NP_060117.3	Q8IY81	RRMJ3_HUMAN	FtsJ homolog 3 (E. coli)	33					RNA methylation|rRNA processing	nucleolus	methyltransferase activity|nucleic acid binding			breast(2)|central_nervous_system(1)|endometrium(6)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	27						GATTGAGCTGGATCAGCTTGA	0.562000													5	14					0.0215528	0.0218018	1	1	0
DOCK9	23348	broad.mit.edu	37	13	99498236	99498236	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr13:99498236C>G	ENST00000376460.1	-	38	4151	c.4071G>C	c.(4069-4071)atG>atC	p.M1357I	DOCK9_ENST00000339416.2_Missense_Mutation_p.M1358I|DOCK9_ENST00000448493.2_Missense_Mutation_p.D1382H	NM_001130048.1|NM_015296.2	NP_001123520.1|NP_056111.1	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9	1358					blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(18)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	59	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TGGCATGCATCATTCCTGTTC	0.493000													6	10					0	0	1	0	0
TSIX	9383	broad.mit.edu	37	X	73047089	73047089	+	RNA	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:73047089C>A	ENST00000604411.1	+	0	35050				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						CTGCACCTATCAGGCAGGGGT	0.488000													31	112					2.68265e-12	2.89618e-12	1	1	0
ZNF436	80818	broad.mit.edu	37	1	23688594	23688594	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:23688594G>A	ENST00000314011.4	-	4	1417	c.1281C>T	c.(1279-1281)ttC>ttT	p.F427F	ZNF436_ENST00000374608.3_Silent_p.F427F	NM_001077195.1	NP_001070663.1	Q9C0F3	ZN436_HUMAN	zinc finger protein 436	427					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	19		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;5.5e-08)|COAD - Colon adenocarcinoma(152;3.09e-06)|GBM - Glioblastoma multiforme(114;5.97e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000977)|KIRC - Kidney renal clear cell carcinoma(1967;0.00336)|STAD - Stomach adenocarcinoma(196;0.0127)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.187)		AGCTCTGGGTGAAACCTTTCC	0.483000													46	112					0	0	1	0	0
PYGL	5836	broad.mit.edu	37	14	51379841	51379841	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr14:51379841C>G	ENST00000216392.7	-	13	1858	c.1526G>C	c.(1525-1527)gGa>gCa	p.G509A	RP11-218E20.5_ENST00000557343.1_RNA|PYGL_ENST00000532462.1_Missense_Mutation_p.G509A|PYGL_ENST00000544180.2_Missense_Mutation_p.G475A	NM_002863.4	NP_002854.3	P06737	PYGL_HUMAN	phosphorylase, glycogen, liver	509					glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(1)|skin(3)	25	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	ATAGTCTTCTCCAATTTTCTT	0.468000													6	19					0	0	1	0	0
CHD2	1106	broad.mit.edu	37	15	93540221	93540221	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr15:93540221C>G	ENST00000394196.4	+	29	4698	c.3630C>G	c.(3628-3630)atC>atG	p.I1210M	CHD2_ENST00000557381.1_Missense_Mutation_p.I1210M	NM_001271.3	NP_001262.3	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1210					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	47	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			GTCCAACAATCAAGATATCCG	0.383000													10	15					0	0	1	0	0
PLK3	1263	broad.mit.edu	37	1	45269843	45269843	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:45269843G>A	ENST00000372201.4	+	11	1506	c.1267G>A	c.(1267-1269)Gaa>Aaa	p.E423K	PLK3_ENST00000465443.1_3'UTR	NM_004073.2	NP_004064.2	Q9H4B4	PLK3_HUMAN	polo-like kinase 3	423						membrane	ATP binding|protein binding|protein serine/threonine kinase activity			endometrium(4)|large_intestine(2)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(166;0.155)					AGGATTTGAAGAAGGTCTGAC	0.557000													28	56					0	0	1	0	0
CCT5	22948	broad.mit.edu	37	5	10262689	10262689	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr5:10262689G>T	ENST00000280326.4	+	9	1696	c.1276G>T	c.(1276-1278)Gag>Tag	p.E426*	CCT5_ENST00000506600.1_Nonsense_Mutation_p.E333*|CCT5_ENST00000515390.1_Nonsense_Mutation_p.E371*|CCT5_ENST00000515676.1_Nonsense_Mutation_p.E388*|CCT5_ENST00000503026.1_Nonsense_Mutation_p.E405*	NM_012073.3	NP_036205.1	P48643	TCPE_HUMAN	chaperonin containing TCP1, subunit 5 (epsilon)	426					'de novo' posttranslational protein folding|response to virus	microtubule organizing center|nucleolus	ATP binding|unfolded protein binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(2)	26						AGGGGCTGCTGAGATATCCTG	0.522000													4	150					0.00024832	0.000257686	1	1	0
SLC4A5	57835	broad.mit.edu	37	2	74480183	74480183	+	Missense_Mutation	SNP	C	C	T	rs145653085		TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:74480183C>T	ENST00000394019.2	-	15	1583	c.1186G>A	c.(1186-1188)Gag>Aag	p.E396K	SLC4A5_ENST00000423644.1_Missense_Mutation_p.E396K|SLC4A5_ENST00000346834.4_Missense_Mutation_p.E396K|SLC4A5_ENST00000357822.5_Missense_Mutation_p.E396K|SLC4A5_ENST00000359484.4_Missense_Mutation_p.E332K|SLC4A5_ENST00000377634.4_Missense_Mutation_p.E396K|SLC4A5_ENST00000483195.1_5'UTR|SLC4A5_ENST00000358683.4_Missense_Mutation_p.E332K|RP11-287D1.3_ENST00000451608.2_3'UTR|SLC4A5_ENST00000377632.1_Missense_Mutation_p.E396K	NM_133478.2	NP_597812.1	Q9BY07	S4A5_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 5	396						apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						ACGATGACCTCATCCAGAAAT	0.532000													9	52					0	0	1	0	0
EIF4ENIF1	56478	broad.mit.edu	37	22	31838022	31838022	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr22:31838022C>T	ENST00000397525.1	-	17	2512	c.2289G>A	c.(2287-2289)caG>caA	p.Q763Q	EIF4ENIF1_ENST00000344710.5_Silent_p.Q589Q|EIF4ENIF1_ENST00000397523.1_Silent_p.Q739Q|EIF4ENIF1_ENST00000330125.5_Silent_p.Q763Q|EIF4ENIF1_ENST00000382180.2_Silent_p.Q418Q	NM_001164501.1	NP_001157973.1	Q9NRA8	4ET_HUMAN	eukaryotic translation initiation factor 4E nuclear import factor 1	763						nucleus	protein binding|protein transporter activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						ACGAAGACCTCTGTAATGCTG	0.488000													14	89					0	0	1	0	0
TAS2R39	259285	broad.mit.edu	37	7	142881081	142881081	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:142881081C>T	ENST00000446620.1	+	1	570	c.570C>T	c.(568-570)atC>atT	p.I190I		NM_176881.2	NP_795362.2	P59534	T2R39_HUMAN	taste receptor, type 2, member 39	190					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20	Melanoma(164;0.059)					CTTTCCCTATCCACTCCTCCA	0.438000													14	41					0	0	1	0	0
RPSA	3921	broad.mit.edu	37	3	39453526	39453526	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:39453526C>T	ENST00000301821.6	+	6	876	c.767C>T	c.(766-768)tCt>tTt	p.S256F	RPSA_ENST00000443003.1_Missense_Mutation_p.S261F|RPSA_ENST00000478027.1_3'UTR	NM_001012321.1|NM_002295.4	NP_001012321.1|NP_002286.2	P08865	RSSA_HUMAN	ribosomal protein SA	256	Laminin-binding.				cell adhesion|endocrine pancreas development|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit assembly|rRNA export from nucleus|translational elongation|translational termination|viral transcription	90S preribosome|cytosolic small ribosomal subunit|nucleus|plasma membrane	protein binding|receptor activity|ribosome binding|structural constituent of ribosome			endometrium(1)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	7				KIRC - Kidney renal clear cell carcinoma(284;0.0509)|Kidney(284;0.064)		CAGGTGCCCTCTGTGCCTATT	0.458000													23	61					0	0	1	0	0
UMODL1	89766	broad.mit.edu	37	21	43529671	43529671	+	Splice_Site	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr21:43529671G>A	ENST00000400424.2	+	10	1699		c.e10-1		UMODL1_ENST00000408910.2_Splice_Site|UMODL1_ENST00000400427.1_Splice_Site|UMODL1_ENST00000408989.2_Splice_Site	NM_001199528.2	NP_001186457	Q5DID0	UROL1_HUMAN	uromodulin-like 1							cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(22)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	47						CCCCCTGGCAGACTGGGACGA	0.577000													14	68					0	0	1	0	0
SLCO4C1	353189	broad.mit.edu	37	5	101631717	101631717	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr5:101631717C>G	ENST00000310954.6	-	1	536	c.250G>C	c.(250-252)Gag>Cag	p.E84Q		NM_180991.4	NP_851322.3	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family, member 4C1	84					cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	50		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		GACCCCTCCTCAAACTCGGAC	0.587000													24	34					0	0	1	0	0
CLLU1OS	574016	broad.mit.edu	37	12	92814855	92814855	+	Silent	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:92814855C>G	ENST00000378487.2	-	3	238	c.237G>C	c.(235-237)gtG>gtC	p.V79V	CLLU1OS_ENST00000538965.1_Silent_p.V79V	NM_001025232.1	NP_001020403.1	Q5K130	CLU1O_HUMAN	chronic lymphocytic leukemia up-regulated 1 opposite strand	79										large_intestine(1)|lung(7)	8						TTCTCCTTGTCACATTTCCTT	0.433000													65	118					0	0	1	0	0
TRPM3	80036	broad.mit.edu	37	9	73736162	73736162	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr9:73736162G>C	ENST00000377110.3	-	1	352	c.109C>G	c.(109-111)Cga>Gga	p.R37G	TRPM3_ENST00000423814.3_Intron|TRPM3_ENST00000377111.2_Missense_Mutation_p.R37G|TRPM3_ENST00000357533.2_Intron			Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3							integral to membrane	calcium channel activity	p.R37R(1)		NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						TTTAGGGGTCGAGGAGCATCA	0.498000													22	20					0	0	1	0	0
OR10AG1	282770	broad.mit.edu	37	11	55735632	55735632	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:55735632C>G	ENST00000312345.2	-	1	358	c.308G>C	c.(307-309)tGt>tCt	p.C103S		NM_001005491.1	NP_001005491.1	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG, member 1	103					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(24)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	40	Esophageal squamous(21;0.0137)					CAGAAGGAGACACTCCGTGCC	0.428000													30	41					0	0	1	0	0
TARDBP	23435	broad.mit.edu	37	1	11076934	11076934	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:11076934C>A	ENST00000240185.3	+	3	386	c.272C>A	c.(271-273)tCa>tAa	p.S91*	TARDBP_ENST00000439080.2_Intron|TARDBP_ENST00000315091.3_Nonsense_Mutation_p.S91*	NM_007375.3	NP_031401.1	Q13148	TADBP_HUMAN	TAR DNA binding protein	91					3'-UTR-mediated mRNA stabilization|cell death|mRNA processing|negative regulation by host of viral transcription|RNA splicing|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|mRNA 3'-UTR binding|nucleotide binding|protein binding|sequence-specific DNA binding transcription factor activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(3)|ovary(2)	11	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0578)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.37e-07)|COAD - Colon adenocarcinoma(227;7.38e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)		ACAGATGCTTCATCAGCAGTG	0.368000													24	63					1.64293e-13	1.78976e-13	1	1	0
TMEM38A	79041	broad.mit.edu	37	19	16798977	16798977	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:16798977C>G	ENST00000187762.2	+	6	786	c.695C>G	c.(694-696)tCa>tGa	p.S232*		NM_024074.1	NP_076979.1	Q9H6F2	TM38A_HUMAN	transmembrane protein 38A	232						integral to membrane|nuclear membrane|sarcoplasmic reticulum membrane	potassium channel activity			central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(1)	15						GCCACCCACTCACACAGCTCC	0.612000													42	254					0	0	1	0	0
NECAB3	63941	broad.mit.edu	37	20	32246632	32246632	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr20:32246632G>A	ENST00000246190.6	-	9	943	c.888C>T	c.(886-888)ctC>ctT	p.L296L	NECAB3_ENST00000606525.1_5'UTR|NECAB3_ENST00000375238.4_Silent_p.L262L	NM_031232.3	NP_112509.3	Q96P71	NECA3_HUMAN	N-terminal EF-hand calcium binding protein 3	296					antibiotic biosynthetic process|protein metabolic process|protein secretion|regulation of amyloid precursor protein biosynthetic process	endoplasmic reticulum membrane|Golgi cis cisterna|nucleus	calcium ion binding|oxidoreductase activity|protein binding			large_intestine(3)|lung(5)|skin(2)	10						TCTGGGCCATGAGGATGTGCT	0.652000													3	16					0	0	1	0	0
NLGN3	54413	broad.mit.edu	37	X	70368014	70368014	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:70368014G>A	ENST00000374051.3	+	2	737	c.415G>A	c.(415-417)Gaa>Aaa	p.E139K	NLGN3_ENST00000358741.3_Missense_Mutation_p.E139K|NLGN3_ENST00000536169.1_Missense_Mutation_p.E139K	NM_018977.3	NP_061850.2	Q9NZ94	NLGN3_HUMAN	neuroligin 3	139					neuron cell-cell adhesion|positive regulation of synaptogenesis|receptor-mediated endocytosis|social behavior|synapse assembly	cell surface|endocytic vesicle|integral to plasma membrane|synapse	neurexin binding|receptor activity			biliary_tract(1)|breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(10)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	37	Renal(35;0.156)					GGAGCCCAACGAAGACTGTCT	0.597000													11	54					0	0	1	0	0
SERPINA13P	388007	broad.mit.edu	37	14	95109918	95109918	+	RNA	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr14:95109918C>G	ENST00000469935.1	+	0	955					NR_015340.1																						GCCACCGCTTCCTGCACGACC	0.587000													8	26					0	0	1	0	0
TEAD2	8463	broad.mit.edu	37	19	49858459	49858459	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:49858459G>T	ENST00000377214.4	-	5	844	c.482C>A	c.(481-483)tCt>tAt	p.S161Y	TEAD2_ENST00000601519.1_Missense_Mutation_p.S161Y|TEAD2_ENST00000539846.1_Missense_Mutation_p.S30Y|TEAD2_ENST00000593945.1_Missense_Mutation_p.S162Y|TEAD2_ENST00000598397.1_5'UTR|TEAD2_ENST00000311227.2_Missense_Mutation_p.S158Y|TEAD2_ENST00000598810.1_Missense_Mutation_p.S162Y			Q15562	TEAD2_HUMAN	TEA domain family member 2	158	Pro-rich.				hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)	29		all_lung(116;7.65e-05)|Lung NSC(112;0.000132)|all_neural(266;0.0506)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00093)|GBM - Glioblastoma multiforme(486;0.0467)		GAAAAGCTCAGAGGCCTGGAT	0.577000													4	24					0.00024832	0.000257686	1	1	0
ICA1	3382	broad.mit.edu	37	7	8196838	8196838	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:8196838G>T	ENST00000402384.3	-	8	978	c.712C>A	c.(712-714)Ctg>Atg	p.L238M	ICA1_ENST00000406470.2_Missense_Mutation_p.L238M|ICA1_ENST00000265577.7_Missense_Mutation_p.L237M|ICA1_ENST00000422063.2_Missense_Mutation_p.L238M|ICA1_ENST00000396675.3_Missense_Mutation_p.L238M|ICA1_ENST00000401396.1_Missense_Mutation_p.L226M|ICA1_ENST00000407906.1_Missense_Mutation_p.L238M			Q05084	ICA69_HUMAN	islet cell autoantigen 1, 69kDa	238	AH.				neurotransmitter transport	cell junction|cytosol|Golgi membrane|nucleus|secretory granule membrane|synaptic vesicle membrane|transport vesicle membrane				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(8)|urinary_tract(1)	23		Ovarian(82;0.0612)		UCEC - Uterine corpus endometrioid carcinoma (126;0.246)		AAATGAAGCAGAGTGGTCTGC	0.393000													34	35					1.26612e-14	1.38554e-14	1	1	0
CDK11A	728642	broad.mit.edu	37	1	1636406	1636406	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:1636406G>A	ENST00000356200.3	-	12	1527	c.1293C>T	c.(1291-1293)atC>atT	p.I431I	CDK11A_ENST00000404249.3_Silent_p.I465I|CDK11A_ENST00000357760.2_Silent_p.I464I|CDK11A_ENST00000358779.5_Silent_p.I455I|CDK11A_ENST00000378633.1_Silent_p.I468I|RP1-283E3.8_ENST00000598846.1_RNA|CDK11A_ENST00000378638.2_Silent_p.I431I					cyclin-dependent kinase 11A											central_nervous_system(1)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(4)|stomach(1)|urinary_tract(1)	18						TCAGGGACGTGATCGGGAAGC	0.547000													84	134					0	0	1	0	0
PALM	5064	broad.mit.edu	37	19	731233	731233	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:731233G>C	ENST00000264560.7	+	5	602	c.408G>C	c.(406-408)atG>atC	p.M136I	PALM_ENST00000593172.1_3'UTR|PALM_ENST00000338448.5_Missense_Mutation_p.M136I	NM_001040134.1	NP_001035224.1	O75781	PALM_HUMAN	paralemmin	136					cellular component movement|negative regulation of adenylate cyclase activity|negative regulation of dopamine receptor signaling pathway|positive regulation of filopodium assembly|regulation of cell shape	cytoplasmic membrane-bounded vesicle|filopodium membrane|integral to plasma membrane				endometrium(2)|large_intestine(1)|lung(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	11		all_epithelial(18;2.19e-21)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)|Lung(535;0.201)		AGGTGGTGATGAATTCACAGC	0.697000													3	4					0	0	1	0	0
ACCSL	390110	broad.mit.edu	37	11	44069600	44069600	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:44069600C>G	ENST00000378832.1	+	1	70	c.14C>G	c.(13-15)tCa>tGa	p.S5*		NM_001031854.2	NP_001027025.2	Q4AC99	1A1L2_HUMAN	1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)-like	5							1-aminocyclopropane-1-carboxylate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			central_nervous_system(1)|endometrium(6)|large_intestine(5)|lung(14)|ovary(5)|pancreas(1)|skin(2)	34						AGTCATCGGTCAGACACCCTT	0.552000													11	43					0	0	1	0	0
DDX25	29118	broad.mit.edu	37	11	125778370	125778370	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:125778370G>C	ENST00000263576.6	+	6	634	c.479G>C	c.(478-480)aGa>aCa	p.R160T	RP11-680F20.9_ENST00000533033.2_RNA|DDX25_ENST00000525943.1_3'UTR	NM_013264.4	NP_037396.3	Q9UHL0	DDX25_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 25	160	Helicase ATP-binding.				mRNA export from nucleus|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|nucleus	ATP binding|ATP-dependent RNA helicase activity|RNA binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)	10	all_hematologic(175;0.177)	Breast(109;0.0021)|all_lung(97;0.0203)|Lung NSC(97;0.0203)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.14e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.046)		ATGTTAAGCAGAGTTAATGCC	0.468000													17	99					0	0	1	0	0
SLC4A3	6508	broad.mit.edu	37	2	220496757	220496757	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:220496757C>T	ENST00000358055.3	+	7	1391	c.879C>T	c.(877-879)ggC>ggT	p.G293G	SLC4A3_ENST00000317151.3_Silent_p.G293G|SLC4A3_ENST00000373762.3_Silent_p.G320G|SLC4A3_ENST00000273063.6_Silent_p.G320G|SLC4A3_ENST00000373760.2_Silent_p.G293G|SLC4A3_ENST00000497589.1_3'UTR			P48751	B3A3_HUMAN	solute carrier family 4 (anion exchanger), member 3	293					bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	51		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGACGCAGGGCGGGAGGGGCA	0.627000													14	33					0	0	1	0	0
IRF3	3661	broad.mit.edu	37	19	50167973	50167973	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:50167973G>A	ENST00000597198.1	-	2	504	c.123C>T	c.(121-123)ggC>ggT	p.G41G	IRF3_ENST00000596765.1_Intron|IRF3_ENST00000599144.1_Intron|IRF3_ENST00000599223.1_Silent_p.G41G|IRF3_ENST00000598808.1_Intron|IRF3_ENST00000593922.1_Intron|IRF3_ENST00000309877.7_Silent_p.G41G|IRF3_ENST00000600022.1_Intron|IRF3_ENST00000601291.1_Silent_p.G41G|IRF3_ENST00000596822.1_Intron|IRF3_ENST00000600911.1_Silent_p.G41G|IRF3_ENST00000377139.3_Silent_p.G41G|IRF3_ENST00000377135.4_Silent_p.G41G|IRF3_ENST00000442265.2_Silent_p.G41G			Q14653	IRF3_HUMAN	interferon regulatory factor 3	41					interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|response to virus|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|endosome membrane|nucleoplasm|plasma membrane	DNA binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			breast(1)|large_intestine(2)|lung(4)|ovary(2)|stomach(1)	10		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.02)		CCTGCCGTAGGCCGTGCTTCC	0.662000													58	69					0	0	1	0	0
ZNF695	57116	broad.mit.edu	37	1	247151090	247151090	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:247151090C>T	ENST00000339986.7	-	4	874	c.727G>A	c.(727-729)Gaa>Aaa	p.E243K	ZNF695_ENST00000487338.2_Intron|ZNF695_ENST00000498046.2_Intron	NM_020394.4	NP_065127	Q8IW36	ZN695_HUMAN	zinc finger protein 695	243					regulation of transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			endometrium(1)|large_intestine(1)|lung(9)|prostate(1)|urinary_tract(1)	13	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			TTACATTCTTCACATTTGCAA	0.358000													23	35					0	0	1	0	0
ZNF365	22891	broad.mit.edu	37	10	64382990	64382990	+	Missense_Mutation	SNP	C	C	T	rs113542007	byFrequency	TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr10:64382990C>T	ENST00000410046.3	+	5	1389	c.1109C>T	c.(1108-1110)aCg>aTg	p.T370M	ZNF365_ENST00000395251.1_Intron	NM_199451.2	NP_955523.1	Q70YC4	TALAN_HUMAN	zinc finger protein 365	124										breast(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27	Prostate(12;0.0297)|all_hematologic(501;0.228)					AATCCCTGGACGTCTTCCACG	0.463000													25	74					0	0	1	0	0
RPL31	6160	broad.mit.edu	37	2	101620642	101620642	+	Silent	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:101620642C>A	ENST00000409711.1	+	2	141	c.130C>A	c.(130-132)Cgg>Agg	p.R44R	RPL31_ENST00000409320.3_Silent_p.R44R|RPL31_ENST00000409038.1_Silent_p.R44R|RPL31_ENST00000264258.3_Silent_p.R44R|RPL31_ENST00000409650.1_Silent_p.R44R|RPL31_ENST00000409028.4_Silent_p.R44R|RPL31_ENST00000409000.1_Silent_p.R44R|RPL31_ENST00000409733.1_Silent_p.R44R			P62899	RL31_HUMAN	ribosomal protein L31	44					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome			kidney(1)|large_intestine(2)|lung(1)|prostate(1)|urinary_tract(3)	8						GCGTGCACCTCGGGCACTCAA	0.448000													13	57					0.000308642	0.00031925	1	1	0
MRTO4	51154	broad.mit.edu	37	1	19585286	19585286	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:19585286G>C	ENST00000330263.4	+	8	979	c.682G>C	c.(682-684)Gag>Cag	p.E228Q		NM_016183.3	NP_057267.2	Q9UKD2	MRT4_HUMAN	mRNA turnover 4 homolog (S. cerevisiae)	228					ribosome biogenesis	nuclear membrane|nucleolus				breast(1)|endometrium(1)|large_intestine(1)|liver(2)|ovary(1)|pancreas(1)|stomach(1)	8		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.87e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|GBM - Glioblastoma multiforme(114;0.00301)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GAGCGCATCTGAGTCCACAGA	0.517000													19	66					0	0	1	0	0
PCIF1	63935	broad.mit.edu	37	20	44572019	44572019	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr20:44572019C>T	ENST00000372409.3	+	9	1226	c.862C>T	c.(862-864)Ctc>Ttc	p.L288F		NM_022104.3	NP_071387.1	Q9H4Z3	PCIF1_HUMAN	PDX1 C-terminal inhibiting factor 1	288						nucleus				central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	20						CAAGCGCCTGCTCTTTAAATA	0.542000													5	62					0	0	1	0	0
OR6K6	128371	broad.mit.edu	37	1	158724754	158724754	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:158724754G>A	ENST00000368144.2	+	1	245	c.149G>A	c.(148-150)aGa>aAa	p.R50K		NM_001005184.1	NP_001005184.1	Q8NGW6	OR6K6_HUMAN	olfactory receptor, family 6, subfamily K, member 6	50					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(5)|lung(17)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_hematologic(112;0.0378)					CATGCGCACAGAGGTGGCCTC	0.463000													32	140					0	0	1	0	0
MBTPS1	8720	broad.mit.edu	37	16	84132724	84132724	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr16:84132724C>G	ENST00000343411.3	-	3	850	c.355G>C	c.(355-357)Gat>Cat	p.D119H		NM_003791.2	NP_003782.1	Q14703	MBTP1_HUMAN	membrane-bound transcription factor peptidase, site 1	119					cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|lung(10)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						TTTGGATGATCTTCAAGTGTT	0.423000													14	63					0	0	1	0	0
COL1A2	1278	broad.mit.edu	37	7	94057055	94057055	+	Silent	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:94057055C>G	ENST00000297268.6	+	49	3855	c.3384C>G	c.(3382-3384)ctC>ctG	p.L1128L		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	1128					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging	p.L1128L(1)	COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	CACCTTCTCTCAGACCCAAGG	0.522000										HNSCC(75;0.22)			10	43					0	0	1	0	0
SULT1C2	6819	broad.mit.edu	37	2	108921937	108921937	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:108921937G>C	ENST00000326853.5	+	8	1150	c.697G>C	c.(697-699)Gat>Cat	p.D233H	SULT1C2_ENST00000437390.2_Missense_Mutation_p.D236H|SULT1C2_ENST00000409880.1_Missense_Mutation_p.D185H|SULT1C2_ENST00000251481.6_Missense_Mutation_p.D222H	NM_176825.2	NP_789795.1	O00338	ST1C2_HUMAN	sulfotransferase family, cytosolic, 1C, member 2	222					3'-phosphoadenosine 5'-phosphosulfate metabolic process|amine metabolic process|sulfation|xenobiotic metabolic process	cytosol|microtubule cytoskeleton	sulfotransferase activity			NS(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	20						AACAGTGCTAGATAAAATTGT	0.418000													24	32					0	0	1	0	0
FAM193A	8603	broad.mit.edu	37	4	2659602	2659602	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr4:2659602G>A	ENST00000324666.5	+	6	862	c.511G>A	c.(511-513)Gaa>Aaa	p.E171K	FAM193A_ENST00000505311.1_Missense_Mutation_p.E171K|FAM193A_ENST00000382839.3_Missense_Mutation_p.E171K|FAM193A_ENST00000545951.1_Missense_Mutation_p.E171K|FAM193A_ENST00000502458.1_Missense_Mutation_p.E195K	NM_001256666.1	NP_001243595.1	P78312	F193A_HUMAN	family with sequence similarity 193, member A	171										NS(2)|breast(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(12)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	40						ATTCATTGAAGAACAGGTAAG	0.373000													20	182					0	0	1	0	0
RACGAP1	29127	broad.mit.edu	37	12	50388223	50388223	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:50388223C>T	ENST00000434422.1	-	12	1415	c.1114G>A	c.(1114-1116)Gag>Aag	p.E372K	RACGAP1_ENST00000454520.2_Missense_Mutation_p.E372K|RACGAP1_ENST00000551016.1_Missense_Mutation_p.E372K|RACGAP1_ENST00000312377.5_Missense_Mutation_p.E372K|RACGAP1_ENST00000427314.2_Missense_Mutation_p.E372K|RACGAP1_ENST00000547905.1_Missense_Mutation_p.E372K			Q9H0H5	RGAP1_HUMAN	Rac GTPase activating protein 1	372	Rho-GAP.				blood coagulation|cytokinesis, actomyosin contractile ring assembly|cytokinesis, initiation of separation|embryo development|microtubule-based movement|neuroblast proliferation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|spermatogenesis|sulfate transport	acrosomal vesicle|cytosol|microtubule|midbody|nucleus|spindle	alpha-tubulin binding|beta-tubulin binding|gamma-tubulin binding|GTPase activator activity|metal ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(6)	14						TGCTCAATCTCATTTACACAA	0.368000													10	50					0	0	1	0	0
CNNM4	26504	broad.mit.edu	37	2	97464824	97464824	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:97464824C>G	ENST00000377075.2	+	4	1810	c.1712C>G	c.(1711-1713)tCa>tGa	p.S571*	CNNM4_ENST00000496186.1_3'UTR|CNNM4_ENST00000540067.1_Nonsense_Mutation_p.S58*	NM_020184.3	NP_064569.3	Q6P4Q7	CNNM4_HUMAN	cyclin M4	571					biomineral tissue development|ion transport|response to stimulus|visual perception	integral to membrane|plasma membrane				breast(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)	20						TCCCTGATATCAGAGAAGATC	0.532000													5	53					0	0	1	0	0
CSTF2T	23283	broad.mit.edu	37	10	53458721	53458721	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr10:53458721C>T	ENST00000331173.4	-	1	634	c.589G>A	c.(589-591)Gtc>Atc	p.V197I	PRKG1_ENST00000401604.2_Intron|PRKG1_ENST00000373985.1_Intron|PRKG1_ENST00000373980.4_Intron	NM_015235.2	NP_056050.1	Q9H0L4	CSTFT_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant	197					mRNA processing	nucleus	nucleotide binding|RNA binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(6)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	30				COAD - Colon adenocarcinoma(2;0.00736)|Colorectal(2;0.00898)|all cancers(4;0.0188)|GBM - Glioblastoma multiforme(4;0.0778)|Epithelial(53;0.122)		AGTGGTGTGACATGTATCTTC	0.512000													6	55					0	0	1	0	0
ZNF157	7712	broad.mit.edu	37	X	47272750	47272750	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:47272750G>C	ENST00000377073.3	+	4	1364	c.1278G>C	c.(1276-1278)aaG>aaC	p.K426N		NM_003446.3	NP_003437.2	P51786	ZN157_HUMAN	zinc finger protein 157	426					negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(5)|upper_aerodigestive_tract(1)	11						TCAGTATGAAGAAATCCCTTT	0.413000													9	19					0	0	1	0	0
FAM60A	58516	broad.mit.edu	37	12	31435710	31435710	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr12:31435710G>A	ENST00000337682.4	-	6	970	c.602C>T	c.(601-603)gCa>gTa	p.A201V	FAM60A_ENST00000539409.1_Missense_Mutation_p.A53V|FAM60A_ENST00000542983.1_Missense_Mutation_p.A53V|FAM60A_ENST00000454658.2_Missense_Mutation_p.A201V|FAM60A_ENST00000395766.1_Missense_Mutation_p.A53V	NM_001135812.1	NP_001129284.1	Q9NP50	FA60A_HUMAN	family with sequence similarity 60, member A	201										large_intestine(1)|lung(2)	3	all_cancers(9;5.22e-13)|all_epithelial(9;4e-13)|all_lung(12;1.2e-11)|Lung NSC(12;2.17e-09)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0207)|Lung SC(12;0.0592)|Esophageal squamous(101;0.162)					CTCAGCAGCTGCTTTCTTATT	0.468000													5	32					0	0	1	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14791438	14791438	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr18:14791438A>T	ENST00000358984.4	+	16	1953	c.1773A>T	c.(1771-1773)ttA>ttT	p.L591F	ANKRD30B_ENST00000579292.1_Intron|ANKRD30B_ENST00000447268.2_Missense_Mutation_p.L591F	NM_001145029.1	NP_001138501.1	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	591										breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						ATGTGTATTTACCCAAAGCTA	0.289000													6	31					0	0	1	0	0
DLAT	1737	broad.mit.edu	37	11	111922053	111922053	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:111922053G>A	ENST00000280346.6	+	11	2153	c.1494G>A	c.(1492-1494)tgG>tgA	p.W498*	DLAT_ENST00000393051.1_Nonsense_Mutation_p.W393*|DLAT_ENST00000537636.1_Nonsense_Mutation_p.W269*	NM_001931.4	NP_001922.2	P10515	ODP2_HUMAN	dihydrolipoamide S-acetyltransferase	498	Catalytic (By similarity).				glycolysis|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial pyruvate dehydrogenase complex	dihydrolipoyllysine-residue acetyltransferase activity|protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(10)|ovary(1)|skin(1)	22		all_cancers(61;4.53e-11)|all_epithelial(67;2.76e-06)|Melanoma(852;9.42e-06)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0512)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)		Epithelial(105;4.87e-07)|BRCA - Breast invasive adenocarcinoma(274;6.83e-07)|all cancers(92;9.63e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0557)	NADH(DB00157)	ATTCTTCTTGGATGGACACAG	0.358000													15	69					0	0	1	0	0
ST13	6767	broad.mit.edu	37	22	41228614	41228614	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr22:41228614C>G	ENST00000216218.3	-	8	1121	c.640G>C	c.(640-642)Gat>Cat	p.D214H		NM_003932.3	NP_003923.2	P50502	F10A1_HUMAN	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)	214							protein binding, bridging			cervix(1)|large_intestine(1)|lung(3)|skin(1)	6						GCATCTTCATCATAATCCAAT	0.408000													6	43					0	0	1	0	0
SLC4A5	57835	broad.mit.edu	37	2	74492307	74492307	+	Silent	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:74492307G>C	ENST00000394019.2	-	9	883	c.486C>G	c.(484-486)ctC>ctG	p.L162L	SLC4A5_ENST00000423644.1_Silent_p.L162L|SLC4A5_ENST00000346834.4_Silent_p.L162L|SLC4A5_ENST00000357822.5_Silent_p.L162L|SLC4A5_ENST00000359484.4_Silent_p.L98L|SLC4A5_ENST00000377634.4_Silent_p.L162L|SLC4A5_ENST00000483195.1_5'UTR|SLC4A5_ENST00000358683.4_Silent_p.L98L|RP11-287D1.3_ENST00000451608.2_3'UTR|SLC4A5_ENST00000377632.1_Silent_p.L162L	NM_133478.2	NP_597812.1	Q9BY07	S4A5_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 5	162						apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						GGAGCTCGAAGAGGCTGTGCA	0.572000													12	74					0	0	1	0	0
BAI2	576	broad.mit.edu	37	1	32221627	32221627	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:32221627C>G	ENST00000373658.3	-	4	1152	c.811G>C	c.(811-813)Gat>Cat	p.D271H	BAI2_ENST00000398547.1_Missense_Mutation_p.D259H|BAI2_ENST00000398538.1_Missense_Mutation_p.D259H|BAI2_ENST00000398556.3_Missense_Mutation_p.D274H|BAI2_ENST00000527361.1_Missense_Mutation_p.D271H|BAI2_ENST00000257070.4_Missense_Mutation_p.D271H|BAI2_ENST00000373655.2_Missense_Mutation_p.D271H|BAI2_ENST00000398542.1_Missense_Mutation_p.D259H	NM_001703.2	NP_001694.2	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	271					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|large_intestine(7)|liver(2)|lung(24)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	55		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		GTGAACAGATCATTGCTGCTC	0.647000													20	72					0	0	1	0	0
DCHS1	8642	broad.mit.edu	37	11	6648747	6648747	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:6648747C>T	ENST00000299441.3	-	14	5934	c.5523G>A	c.(5521-5523)ttG>ttA	p.L1841L		NM_003737.2	NP_003728.1	Q96JQ0	PCD16_HUMAN	dachsous cadherin-related 1	1841	Cadherin 17.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(16)|liver(1)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	103		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTGTCACTGTCAAAAGCAGCG	0.617000													3	7					0	0	1	0	0
MESDC1	59274	broad.mit.edu	37	15	81294881	81294881	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr15:81294881C>G	ENST00000267984.2	+	1	1587	c.269C>G	c.(268-270)tCc>tGc	p.S90C		NM_022566.2	NP_072088.1	Q9H1K6	MESD1_HUMAN	mesoderm development candidate 1	90										endometrium(1)|lung(2)	3						AAGGGGCTCTCCATCCTCACC	0.711000													3	22					0	0	1	0	0
CRMP1	1400	broad.mit.edu	37	4	5844873	5844873	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr4:5844873G>A	ENST00000324989.7	-	7	1067	c.979C>T	c.(979-981)Ctg>Ttg	p.L327L	CRMP1_ENST00000511535.1_5'UTR|CRMP1_ENST00000397890.2_Silent_p.L213L|CRMP1_ENST00000512574.1_Silent_p.L211L	NM_001014809.1	NP_001014809.1	Q14194	DPYL1_HUMAN	collapsin response mediator protein 1	213					axon guidance|pyrimidine base catabolic process	cytosol|microtubule organizing center|spindle	dihydropyrimidinase activity|protein binding			NS(1)|cervix(2)|endometrium(4)|large_intestine(10)|lung(11)|ovary(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36				Colorectal(103;0.0721)		CCCATCTCCAGGATCCGCTTT	0.542000													16	48					0	0	1	0	0
ZNF471	57573	broad.mit.edu	37	19	57036445	57036445	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:57036445C>G	ENST00000308031.5	+	5	1142	c.1009C>G	c.(1009-1011)Cag>Gag	p.Q337E	ZNF471_ENST00000591537.1_Missense_Mutation_p.I196M|ZNF471_ENST00000593197.1_Intron	NM_020813.2	NP_065864.2	Q9BX82	ZN471_HUMAN	zinc finger protein 471	337					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(2)|lung(8)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	36		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0307)		TGCTCGACATCAGAGATGTCA	0.423000													20	121					0	0	1	0	0
KCNH7	90134	broad.mit.edu	37	2	163693088	163693088	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:163693088G>C	ENST00000332142.5	-	2	365	c.266C>G	c.(265-267)tCa>tGa	p.S89*	KCNH7_ENST00000328032.4_Nonsense_Mutation_p.S89*	NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	89					regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity	p.S89*(2)		NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	CCTCTCTTCTGACCCCAGCAA	0.443000													22	35					0	0	1	0	0
RBBP4	5928	broad.mit.edu	37	1	33135116	33135116	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:33135116G>A	ENST00000373493.5	+	8	1077	c.918G>A	c.(916-918)ctG>ctA	p.L306L	RBBP4_ENST00000458695.2_Silent_p.L271L|RBBP4_ENST00000544435.1_Silent_p.L54L|RBBP4_ENST00000373485.1_Silent_p.L306L|RBBP4_ENST00000414241.3_Silent_p.L305L	NM_001135255.1|NM_005610.2	NP_001128727.1|NP_005601.1	Q09028	RBBP4_HUMAN	retinoblastoma binding protein 4	306					cell cycle|CenH3-containing nucleosome assembly at centromere|DNA replication|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|ESC/E(Z) complex|NuRD complex|NURF complex|Sin3 complex	histone binding|histone deacetylase binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(4)|ovary(1)|prostate(4)|urinary_tract(1)	15		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)				TGAGAAATCTGAAACTTAAGT	0.308000													18	51					0	0	1	0	0
CPE	1363	broad.mit.edu	37	4	166418725	166418725	+	Missense_Mutation	SNP	A	A	T	rs140816537	byFrequency	TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr4:166418725A>T	ENST00000402744.4	+	9	1674	c.1394A>T	c.(1393-1395)gAa>gTa	p.E465V		NM_001873.2	NP_001864.1	P16870	CBPE_HUMAN	carboxypeptidase E	465					cardiac left ventricle morphogenesis|neuropeptide signaling pathway|protein modification process	extracellular region|nucleus|plasma membrane	metallocarboxypeptidase activity|protein binding|zinc ion binding			endometrium(2)|large_intestine(10)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	26	all_hematologic(180;0.221)	Prostate(90;0.0962)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.137)	Glucagon recombinant(DB00040)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GAATTGATGGAATGGTGGAAA	0.303000													8	34					0	0	1	0	0
MDGA1	266727	broad.mit.edu	37	6	37623624	37623624	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:37623624C>T	ENST00000297153.7	-	4	1609	c.431G>A	c.(430-432)cGa>cAa	p.R144Q	MDGA1_ENST00000434837.3_Missense_Mutation_p.R144Q|MDGA1_ENST00000505425.1_Missense_Mutation_p.R144Q			Q8NFP4	MDGA1_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 1	144	Ig-like 2.				brain development|neuron migration|spinal cord association neuron differentiation	anchored to plasma membrane				central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(12)|lung(11)|prostate(1)|skin(2)|urinary_tract(1)	38						GAAGTTGCCTCGCACATCGCT	0.607000													4	32					0	0	1	0	0
PRKCI	5584	broad.mit.edu	37	3	169999005	169999005	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:169999005C>T	ENST00000295797.4	+	10	1239	c.934C>T	c.(934-936)Cat>Tat	p.H312Y		NM_002740.5	NP_002731.4	P41743	KPCI_HUMAN	protein kinase C, iota	312	Protein kinase.				anti-apoptosis|cellular membrane organization|cellular response to insulin stimulus|establishment or maintenance of epithelial cell apical/basal polarity|intracellular signal transduction|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|protein targeting to membrane|secretion|tight junction assembly|vesicle-mediated transport	cytosol|endosome|nucleus|polarisome	ATP binding|phospholipid binding|protein binding|protein kinase C activity|zinc ion binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(16)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	36	all_cancers(22;6.45e-23)|all_epithelial(15;8.52e-28)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			GGCATCCAATCATCCTTTCCT	0.358000													18	71					0	0	1	0	0
BOD1L1	259282	broad.mit.edu	37	4	13602772	13602772	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr4:13602772C>G	ENST00000040738.5	-	10	5887	c.5752G>C	c.(5752-5754)Gag>Cag	p.E1918Q		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	1918							DNA binding										GCTCCAGCCTCAGCTTCCACA	0.448000													64	42					0	0	1	0	0
REV1	51455	broad.mit.edu	37	2	100019149	100019149	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:100019149C>G	ENST00000258428.3	-	21	3727	c.3499G>C	c.(3499-3501)Gat>Cat	p.D1167H	REV1_ENST00000393445.3_Missense_Mutation_p.D1166H	NM_001037872.1|NM_016316.2	NP_001032961.1|NP_057400.1	Q9UBZ9	REV1_HUMAN	REV1, polymerase (DNA directed)	1167	Protein interaction domain; mediates interaction with DNA polymerase zeta.				DNA replication|error-prone translesion synthesis|response to UV	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|magnesium ion binding|protein binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(14)|lung(12)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GTCTTCACATCATTGAATTCA	0.483000								Direct reversal of damage					14	58					0	0	1	0	0
MYO9A	4649	broad.mit.edu	37	15	72189913	72189913	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr15:72189913C>G	ENST00000356056.5	-	25	5403	c.4931G>C	c.(4930-4932)aGa>aCa	p.R1644T	MYO9A_ENST00000444904.1_Missense_Mutation_p.R1625T|MYO9A_ENST00000564571.1_Missense_Mutation_p.R1644T|MYO9A_ENST00000566885.1_Missense_Mutation_p.R1264T|MYO9A_ENST00000563542.1_5'UTR|MYO9A_ENST00000424560.1_Missense_Mutation_p.R1644T	NM_006901.3	NP_008832.2	B2RTY4	MYO9A_HUMAN	myosin IXA	1644	Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(29)|lung(27)|ovary(1)|pancreas(1)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						AAAGTGTTCTCTTTTTGAAAT	0.428000													25	71					0	0	1	0	0
HEPH	9843	broad.mit.edu	37	X	65409696	65409696	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:65409696C>A	ENST00000519389.1	+	6	1320	c.1141C>A	c.(1141-1143)Cca>Aca	p.P381T	HEPH_ENST00000419594.1_Missense_Mutation_p.P330T|HEPH_ENST00000374727.3_Missense_Mutation_p.P330T|HEPH_ENST00000336279.5_Missense_Mutation_p.P60T|HEPH_ENST00000343002.2_Missense_Mutation_p.P327T|HEPH_ENST00000441993.2_Missense_Mutation_p.P330T			Q9BQS7	HEPH_HUMAN	hephaestin	327	Plastocyanin-like 3.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(56)|ovary(5)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	89						TAACATCTTTCCAGCCACCTT	0.483000													7	10					1.06961e-07	1.12819e-07	1	1	0
NCBP2	22916	broad.mit.edu	37	3	196666133	196666133	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:196666133G>C	ENST00000447325.1	-	2	388	c.39C>G	c.(37-39)ttC>ttG	p.F13L	NCBP2_ENST00000422610.1_Missense_Mutation_p.F13L|NCBP2_ENST00000321256.5_Missense_Mutation_p.F83L|NCBP2_ENST00000452404.2_Missense_Mutation_p.F65L|NCBP2_ENST00000427641.2_Intron			P52298	NCBP2_HUMAN	nuclear cap binding protein subunit 2, 20kDa	83					gene silencing by RNA|histone mRNA metabolic process|mRNA 3'-end processing|mRNA capping|mRNA export from nucleus|ncRNA metabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of RNA export from nucleus|positive regulation of viral transcription|regulation of translational initiation|snRNA export from nucleus|spliceosomal snRNP assembly|termination of RNA polymerase II transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytosol|mRNA cap binding complex|nucleoplasm	nucleotide binding|protein binding|RNA 7-methylguanosine cap binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)	5	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;3.42e-24)|all cancers(36;2.27e-22)|OV - Ovarian serous cystadenocarcinoma(49;4.13e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00551)		CCACAAAACAGAATCCACATG	0.428000													8	63					0	0	1	0	0
DNM2	1785	broad.mit.edu	37	19	10941028	10941028	+	Silent	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:10941028C>G	ENST00000314646.5	+	20	2681	c.2517C>G	c.(2515-2517)ccC>ccG	p.P839P	DNM2_ENST00000585892.1_Silent_p.P839P|DNM2_ENST00000389253.4_Silent_p.P839P|DNM2_ENST00000355667.6_Silent_p.P839P|DNM2_ENST00000408974.4_Silent_p.P835P|DNM2_ENST00000359692.6_Silent_p.P835P			P50570	DYN2_HUMAN	dynamin 2	839	Pro-rich.				G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	42			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			TTCGGATCCCCCCAGGGATTC	0.662000			"""F, N, Splice, Mis, O"""		ETP ALL								4	98					0	0	1	0	0
OR6K6	128371	broad.mit.edu	37	1	158725567	158725567	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:158725567A>C	ENST00000368144.2	+	1	1058	c.962A>C	c.(961-963)aAc>aCc	p.N321T		NM_001005184.1	NP_001005184.1	Q8NGW6	OR6K6_HUMAN	olfactory receptor, family 6, subfamily K, member 6	321					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(5)|lung(17)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_hematologic(112;0.0378)					AGCCTGAAAAACAAGGACATG	0.448000													10	138					0	0	1	0	0
OR5M9	390162	broad.mit.edu	37	11	56230147	56230147	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:56230147G>A	ENST00000279791.1	-	1	730	c.731C>T	c.(730-732)aCg>aTg	p.T244M		NM_001004743.1	NP_001004743.1	Q8NGP3	OR5M9_HUMAN	olfactory receptor, family 5, subfamily M, member 9	244					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.T244M(3)		breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(4)|urinary_tract(2)	36	Esophageal squamous(21;0.00448)					AGAAACAGCCGTCAAGTGGGA	0.532000													19	20					0	0	1	0	0
C14orf79	122616	broad.mit.edu	37	14	105452861	105452861	+	Silent	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr14:105452861G>C	ENST00000547315.1	+	1	732	c.93G>C	c.(91-93)ctG>ctC	p.L31L		NM_174891.3	NP_777551.2	Q96F83	CN079_HUMAN	chromosome 14 open reading frame 79	31										breast(1)|endometrium(1)|lung(1)	3		all_cancers(154;0.0798)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.00326)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0181)			CTGAGAGGCTGAGTGATGACA	0.632000													10	23					0	0	1	0	0
VIT	5212	broad.mit.edu	37	2	37032769	37032769	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:37032769G>C	ENST00000379242.3	+	14	1653	c.1351G>C	c.(1351-1353)Gag>Cag	p.E451Q	VIT_ENST00000389975.3_Missense_Mutation_p.E436Q|VIT_ENST00000401530.1_Missense_Mutation_p.E415Q|VIT_ENST00000404084.1_Missense_Mutation_p.E388Q|VIT_ENST00000497382.1_Missense_Mutation_p.E105Q|VIT_ENST00000379241.3_Missense_Mutation_p.E414Q	NM_053276.3	NP_444506.2	Q6UXI7	VITRN_HUMAN	vitrin	436	VWFA 1.					proteinaceous extracellular matrix		p.E451*(1)		autonomic_ganglia(1)|breast(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_hematologic(82;0.248)				TGCTGAAAATGAGAAGCAGTA	0.478000													40	50					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152782775	152782775	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:152782775T>A	ENST00000367255.5	-	21	2952	c.2351A>T	c.(2350-2352)gAa>gTa	p.E784V	SYNE1_ENST00000341594.5_Missense_Mutation_p.E791V|SYNE1_ENST00000367253.4_Missense_Mutation_p.E784V|SYNE1_ENST00000423061.1_Missense_Mutation_p.E791V|SYNE1_ENST00000367248.3_Missense_Mutation_p.E774V|SYNE1_ENST00000413186.2_Missense_Mutation_p.E784V|SYNE1_ENST00000495090.2_Missense_Mutation_p.E351V|SYNE1_ENST00000265368.4_Missense_Mutation_p.E784V|SYNE1_ENST00000448038.1_Missense_Mutation_p.E791V	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	784					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CGCAAACATTTCTTTTCCTTC	0.433000										HNSCC(10;0.0054)			27	78					0	0	1	0	0
DUS1L	64118	broad.mit.edu	37	17	80019827	80019827	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr17:80019827C>G	ENST00000354321.7	-	5	1028	c.543G>C	c.(541-543)caG>caC	p.Q181H	DUS1L_ENST00000306796.5_Missense_Mutation_p.Q181H			Q6P1R4	DUS1L_HUMAN	dihydrouridine synthase 1-like (S. cerevisiae)	181					tRNA processing		flavin adenine dinucleotide binding|tRNA dihydrouridine synthase activity			breast(1)|endometrium(1)|lung(2)|ovary(1)|skin(1)	6	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0211)			GGGGCCCCTTCTGCTCCTTGG	0.662000													10	79					0	0	1	0	0
ZEB2	9839	broad.mit.edu	37	2	145147383	145147383	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:145147383C>T	ENST00000558170.2	-	10	4464	c.3280G>A	c.(3280-3282)Gag>Aag	p.E1094K	ZEB2_ENST00000303660.4_Missense_Mutation_p.E1094K|ZEB2_ENST00000409487.3_Missense_Mutation_p.E1094K|ZEB2_ENST00000539609.3_Missense_Mutation_p.E1070K	NM_014795.3	NP_055610.1	O60315	ZEB2_HUMAN	zinc finger E-box binding homeobox 2	1094	Glu-rich (acidic).					cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding	p.E1094K(1)		breast(3)|central_nervous_system(1)|cervix(2)|endometrium(7)|kidney(6)|large_intestine(23)|lung(45)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	107				BRCA - Breast invasive adenocarcinoma(221;0.112)		TCGCGCGCCTCGCGCTCCGCC	0.617000													17	50					0	0	1	0	0
KLKB1	3818	broad.mit.edu	37	4	187159490	187159490	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr4:187159490C>T	ENST00000264690.6	+	6	756	c.569C>T	c.(568-570)tCa>tTa	p.S190L	KLKB1_ENST00000513864.1_Missense_Mutation_p.S190L	NM_000892.3	NP_000883.2	P03952	KLKB1_HUMAN	kallikrein B, plasma (Fletcher factor) 1	190	Apple 2.				blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	40		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		TCTGGATTCTCACTGAAGCCC	0.473000													12	50					0	0	1	0	0
RAET1K	646024	broad.mit.edu	37	6	150322104	150322104	+	RNA	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:150322104C>G	ENST00000533735.1	-	0	772					NR_024045.1																						TCTCCCACTTCTCTGTCATCT	0.433000													3	7					0	0	1	0	0
FAM122C	159091	broad.mit.edu	37	X	133988222	133988222	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:133988222C>G	ENST00000445123.1	+	12	1829	c.533C>G	c.(532-534)tCt>tGt	p.S178C	FAM122C_ENST00000370784.4_Missense_Mutation_p.L182V|FAM122C_ENST00000370785.3_3'UTR			Q6P4D5	F222C_HUMAN	family with sequence similarity 122C	0										endometrium(2)|kidney(1)|lung(2)	5	Acute lymphoblastic leukemia(192;0.000127)					GTGTCACCTTCTGATACTGGT	0.428000													12	37					0	0	1	0	0
DEGS2	123099	broad.mit.edu	37	14	100615443	100615443	+	Silent	SNP	G	G	A	rs145891510		TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr14:100615443G>A	ENST00000305631.5	-	2	1262	c.687C>T	c.(685-687)ttC>ttT	p.F229F	DEGS2_ENST00000557117.1_5'UTR|DEGS2_ENST00000553834.1_Intron	NM_206918.2	NP_996801.2	Q6QHC5	DEGS2_HUMAN	delta(4)-desaturase, sphingolipid 2	229					fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	sphingosine hydroxylase activity	p.F229F(2)		breast(1)|lung(6)|skin(1)	8		Melanoma(154;0.212)				GCTCGGCCACGAAGTGGCCCG	0.622000													13	67					0	0	1	0	0
MICAL1	64780	broad.mit.edu	37	6	109769440	109769440	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:109769440G>T	ENST00000368952.4	-	13	2168	c.1878C>A	c.(1876-1878)ttC>ttA	p.F626L	MICAL1_ENST00000358577.3_Missense_Mutation_p.F521L|MICAL1_ENST00000358807.3_Missense_Mutation_p.F607L			Q8TDZ2	MICA1_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 1	607					cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|liver(1)|lung(7)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	40		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)		AGGCACTGTGGAAGTGGCTGA	0.597000													13	31					9.05144e-12	9.76096e-12	1	1	0
NAALADL1	10004	broad.mit.edu	37	11	64822077	64822077	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:64822077C>T	ENST00000358658.3	-	5	764	c.737G>A	c.(736-738)cGa>cAa	p.R246Q	NAALADL1_ENST00000355721.3_Missense_Mutation_p.R205Q|NAALADL1_ENST00000339885.2_Missense_Mutation_p.R246Q|NAALADL1_ENST00000355369.2_Missense_Mutation_p.R246Q|NAALADL1_ENST00000340252.4_Missense_Mutation_p.R246Q|NAALADL1_ENST00000356632.3_Missense_Mutation_p.R246Q	NM_005468.2	NP_005459.2	Q9UQQ1	NALDL_HUMAN	N-acetylated alpha-linked acidic dipeptidase-like 1	246					proteolysis	apical plasma membrane|integral to membrane	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity	p.R246Q(1)		autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	29						GTAGGAGCCTCGCTCCACTCC	0.597000											OREG0032001	type=REGULATORY REGION|TFbs=RELA|Dataset=RELA (p65) ChIP-PET Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with paired-end diTag sequencing (ChIP-PET)	6	10					0	0	1	0	0
TMEM26	219623	broad.mit.edu	37	10	63212699	63212699	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr10:63212699G>A	ENST00000399298.3	-	1	509	c.141C>T	c.(139-141)ttC>ttT	p.F47F	TMEM26_ENST00000399293.1_Silent_p.F47F|RP11-809M12.1_ENST00000389640.4_RNA	NM_178505.6	NP_848600.2	Q6ZUK4	TMM26_HUMAN	transmembrane protein 26	47						integral to membrane				kidney(1)|large_intestine(2)|lung(11)|prostate(1)|skin(2)|urinary_tract(1)	18	Prostate(12;0.0112)					CAGTCTCCAGGAAGAGCAAGA	0.627000													10	54					0	0	1	0	0
NID1	4811	broad.mit.edu	37	1	236189248	236189248	+	Silent	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:236189248C>T	ENST00000264187.6	-	8	2014	c.1932G>A	c.(1930-1932)caG>caA	p.Q644Q	NID1_ENST00000366595.3_Silent_p.Q644Q	NM_002508.2	NP_002499.2	P14543	NID1_HUMAN	nidogen 1	644	Nidogen G2 beta-barrel.				cell-matrix adhesion	basement membrane	calcium ion binding			breast(4)|endometrium(9)|kidney(1)|large_intestine(23)|lung(20)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(1)	66	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	TCTTCTCCTCCTGGTTGTACA	0.572000													9	186					0	0	1	0	0
PRKCD	5580	broad.mit.edu	37	3	53220312	53220312	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:53220312G>A	ENST00000394729.2	+	12	1544	c.1216G>A	c.(1216-1218)Gag>Aag	p.E406K	PRKCD_ENST00000330452.3_Missense_Mutation_p.E406K	NM_212539.1	NP_997704.1	Q05655	KPCD_HUMAN	protein kinase C, delta	406	Protein kinase.				activation of phospholipase C activity|cellular component disassembly involved in apoptosis|cellular senescence|interferon-gamma-mediated signaling pathway|intracellular signal transduction|mRNA metabolic process|negative regulation of insulin receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein binding|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of ceramide biosynthetic process|positive regulation of glucosylceramide catabolic process|positive regulation of protein dephosphorylation|positive regulation of sphingomyelin catabolic process|protein stabilization|regulation of receptor activity|termination of signal transduction	cytosol|endoplasmic reticulum|nucleoplasm	ATP binding|calcium-independent protein kinase C activity|enzyme activator activity|enzyme binding|insulin receptor substrate binding|metal ion binding|protein C-terminus binding			breast(1)|central_nervous_system(4)|endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Ovarian(412;0.0728)		OV - Ovarian serous cystadenocarcinoma(275;3.58e-08)|BRCA - Breast invasive adenocarcinoma(193;0.000142)|Kidney(197;0.00153)|KIRC - Kidney renal clear cell carcinoma(197;0.00173)		ACTTGCCGCAGAGAATCCCTT	0.592000													26	47					0	0	1	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103306707	103306707	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:103306707G>C	ENST00000375735.2	+	85	12547	c.12403G>C	c.(12403-12405)Gaa>Caa	p.E4135Q	DYNC2H1_ENST00000334267.7_Missense_Mutation_p.E748Q|DYNC2H1_ENST00000398093.3_Missense_Mutation_p.E4142Q	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	4135					cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		GGAAGGCCCAGAAGATCCCTT	0.413000													12	13					0	0	1	0	0
NUP160	23279	broad.mit.edu	37	11	47825079	47825079	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr11:47825079G>C	ENST00000378460.2	-	22	2732	c.2686C>G	c.(2686-2688)Caa>Gaa	p.Q896E	NUP160_ENST00000528071.1_Missense_Mutation_p.Q782E|NUP160_ENST00000530326.1_Missense_Mutation_p.Q782E	NM_015231.1	NP_056046.1	Q12769	NU160_HUMAN	nucleoporin 160kDa	896					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			NS(1)|biliary_tract(2)|breast(7)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(15)|ovary(6)|prostate(2)|skin(2)|urinary_tract(2)	53						TGTAGCAGTTGAATATAATCC	0.378000													13	57					0	0	1	0	0
D2HGDH	728294	broad.mit.edu	37	2	242695290	242695290	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:242695290C>G	ENST00000321264.4	+	9	1376	c.1167C>G	c.(1165-1167)atC>atG	p.I389M	D2HGDH_ENST00000403782.1_Missense_Mutation_p.I255M|D2HGDH_ENST00000486953.1_3'UTR	NM_152783.3	NP_689996.4	Q8N465	D2HDH_HUMAN	D-2-hydroxyglutarate dehydrogenase	389					2-oxoglutarate metabolic process|cellular protein metabolic process|response to cobalt ion|response to manganese ion|response to zinc ion	mitochondrial matrix	(R)-2-hydroxyglutarate dehydrogenase activity|flavin adenine dinucleotide binding|protein binding			breast(1)|endometrium(3)|lung(10)|skin(1)|urinary_tract(1)	16		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		GGGAAAGGATCACAGAGGCGC	0.632000													17	104					0	0	1	0	0
EMR1	2015	broad.mit.edu	37	19	6935042	6935042	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:6935042G>C	ENST00000312053.4	+	18	2371	c.2334G>C	c.(2332-2334)caG>caC	p.Q778H	EMR1_ENST00000450315.3_Missense_Mutation_p.Q601H|EMR1_ENST00000381407.5_Missense_Mutation_p.Q637H|EMR1_ENST00000381404.4_Missense_Mutation_p.Q759H|EMR1_ENST00000250572.8_Missense_Mutation_p.Q713H	NM_001974.4	NP_001965.3	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 1	778					cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(8)	62	all_hematologic(4;0.166)					TCCTGAGGCAGAGGCTTTCCA	0.488000													22	107					0	0	1	0	0
ASPM	259266	broad.mit.edu	37	1	197073531	197073531	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:197073531C>A	ENST00000367409.4	-	18	5106	c.4850G>T	c.(4849-4851)cGa>cTa	p.R1617L	ASPM_ENST00000294732.7_Intron|ASPM_ENST00000367408.1_Intron	NM_018136.4	NP_060606.3	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	1617					mitosis	cytoplasm|nucleus	calmodulin binding			breast(6)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(9)|large_intestine(28)|liver(1)|lung(87)|ovary(5)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(3)	165						AATATAAGCTCGGAAATGAGT	0.378000													24	68					7.87624e-14	8.59957e-14	1	1	0
CUL4A	8451	broad.mit.edu	37	13	113889383	113889383	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr13:113889383G>C	ENST00000451881.1	+	8	721	c.472G>C	c.(472-474)Gaa>Caa	p.E158Q	CUL4A_ENST00000326335.4_Missense_Mutation_p.E158Q|CUL4A_ENST00000375441.3_Missense_Mutation_p.E158Q|CUL4A_ENST00000375440.4_Missense_Mutation_p.E258Q	NM_001278513.1|NM_003589.2	NP_001265442.1|NP_003580.1	Q13619	CUL4A_HUMAN	cullin 4A	258					cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	ubiquitin protein ligase binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|large_intestine(5)|lung(5)|skin(1)	17	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.112)			TAAGGTTCCAGAATATCTTAA	0.358000													14	25					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167643840	167643840	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr5:167643840G>C	ENST00000519204.1	+	21	3901	c.3783G>C	c.(3781-3783)caG>caC	p.Q1261H	TENM2_ENST00000520394.1_Missense_Mutation_p.Q1143H|TENM2_ENST00000403607.2_Missense_Mutation_p.Q1206H|TENM2_ENST00000518659.1_Missense_Mutation_p.Q1382H|TENM2_ENST00000545108.1_Missense_Mutation_p.Q1381H					teneurin transmembrane protein 2																		AGGTTGACCAGAATGGAATCA	0.522000													11	26					0	0	1	0	0
TNRC18	84629	broad.mit.edu	37	7	5410927	5410927	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:5410927G>A	ENST00000399537.4	-	11	3646	c.3298C>T	c.(3298-3300)Cag>Tag	p.Q1100*	TNRC18_ENST00000430969.1_Nonsense_Mutation_p.Q1100*			O15417	TNC18_HUMAN	trinucleotide repeat containing 18	1100	Pro-rich.						DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)	11		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		GCCGTGGGCTGCAGCAGGAAA	0.692000													5	4					0	0	1	0	0
NEK5	341676	broad.mit.edu	37	13	52650273	52650273	+	Missense_Mutation	SNP	C	C	G	rs139136964	byFrequency	TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr13:52650273C>G	ENST00000355568.4	-	19	1793	c.1654G>C	c.(1654-1656)Gaa>Caa	p.E552Q		NM_199289.1	NP_954983.1	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	552							ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(11)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	39		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		AAGTCTTTTTCAATGTCCTGA	0.294000													3	28					0	0	1	0	0
ZNF14	7561	broad.mit.edu	37	19	19823881	19823881	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:19823881C>G	ENST00000344099.3	-	4	347	c.209G>C	c.(208-210)aGa>aCa	p.R70T		NM_021030.2	NP_066358.2	P17017	ZNF14_HUMAN	zinc finger protein 14	70	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(2)|endometrium(1)|large_intestine(9)|lung(8)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	32		Renal(1328;0.0474)				TTCACAGAGTCTCTCAACCAT	0.323000													34	67					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152496415	152496415	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:152496415G>C	ENST00000427231.2	-	62	9047	c.8845C>G	c.(8845-8847)Ctg>Gtg	p.L2949V	NEB_ENST00000172853.10_Missense_Mutation_p.L2949V|NEB_ENST00000603639.1_Missense_Mutation_p.L2949V|NEB_ENST00000397345.3_Missense_Mutation_p.L2949V|NEB_ENST00000604864.1_Missense_Mutation_p.L2949V|NEB_ENST00000409198.1_Missense_Mutation_p.L2949V	NM_001164507.1|NM_001271208.1	NP_001157979|NP_001258137.1	P20929	NEBU_HUMAN	nebulin	2949					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		ACTTGTTCCAGAGAGTCAGTC	0.388000													10	17					0	0	1	0	0
ARID1A	8289	broad.mit.edu	37	1	27087458	27087458	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:27087458C>T	ENST00000324856.7	+	5	2403	c.2032C>T	c.(2032-2034)Cag>Tag	p.Q678*	ARID1A_ENST00000374152.2_Nonsense_Mutation_p.Q295*|ARID1A_ENST00000457599.2_Nonsense_Mutation_p.Q678*	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	678					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding	p.N675fs*64(1)	ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		TAATCCAGCTCAGTCTCCTTT	0.582000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								21	52					0	0	1	0	0
CTAGE5	4253	broad.mit.edu	37	14	39782547	39782547	+	Missense_Mutation	SNP	A	A	T	rs144905256		TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr14:39782547A>T	ENST00000553728.1	+	18	3015	c.2802A>T	c.(2800-2802)aaA>aaT	p.K934N	CTAGE5_ENST00000396165.4_Missense_Mutation_p.K370N|RP11-407N17.3_ENST00000603904.1_Missense_Mutation_p.K370N|CTAGE5_ENST00000396158.2_Missense_Mutation_p.K404N|CTAGE5_ENST00000280083.3_Missense_Mutation_p.K399N|CTAGE5_ENST00000557038.1_Missense_Mutation_p.K319N|CTAGE5_ENST00000341749.3_Missense_Mutation_p.K387N|CTAGE5_ENST00000348007.3_Missense_Mutation_p.K399N|CTAGE5_ENST00000341502.5_Missense_Mutation_p.K399N|CTAGE5_ENST00000553352.1_Missense_Mutation_p.K370N|CTAGE5_ENST00000556148.1_Missense_Mutation_p.K324N																							TTTTAAGGAAATTAACAGTAG	0.299000													5	34					0	0	1	0	0
SLC6A20	54716	broad.mit.edu	37	3	45812725	45812725	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:45812725C>T	ENST00000358525.4	-	6	1034	c.919G>A	c.(919-921)Gaa>Aaa	p.E307K	SLC6A20_ENST00000353278.4_Missense_Mutation_p.E270K|SLC6A20_ENST00000456124.2_Missense_Mutation_p.E307K	NM_020208.3	NP_064593.1	Q9NP91	S6A20_HUMAN	solute carrier family 6 (proline IMINO transporter), member 20	307					cellular nitrogen compound metabolic process|glycine transport|proline transport	apical plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity	p.E270K(1)|p.E307K(1)		breast(1)|endometrium(1)|large_intestine(6)|ovary(2)|skin(2)|urinary_tract(1)	13				BRCA - Breast invasive adenocarcinoma(193;0.01)|KIRC - Kidney renal clear cell carcinoma(197;0.0225)|Kidney(197;0.0267)		AAGCAGTTTTCATAATTGAAG	0.547000													24	29					0	0	1	0	0
SERPINI2	5276	broad.mit.edu	37	3	167189390	167189390	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:167189390T>G	ENST00000476257.1	-	3	531	c.233A>C	c.(232-234)cAg>cCg	p.Q78P	SERPINI2_ENST00000471111.1_Missense_Mutation_p.Q78P|SERPINI2_ENST00000465031.1_5'UTR|SERPINI2_ENST00000264677.4_Missense_Mutation_p.Q78P|SERPINI2_ENST00000461846.1_Missense_Mutation_p.Q78P			O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin), member 2	78					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(20)|prostate(1)|skin(5)|urinary_tract(1)	41						TGAGGTTTCCTGTTGTTTTAA	0.358000													13	60					0	0	1	0	0
UHRF1BP1	54887	broad.mit.edu	37	6	34840212	34840212	+	Silent	SNP	C	C	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:34840212C>G	ENST00000192788.5	+	21	4491	c.4320C>G	c.(4318-4320)ctC>ctG	p.L1440L	UHRF1BP1_ENST00000452449.2_Intron	NM_017754.3	NP_060224.3	Q6BDS2	URFB1_HUMAN	UHRF1 binding protein 1	1440										breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(24)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	54						TCTTTGAGCTCTGAAACCAGT	0.448000													3	23					0	0	1	0	0
NKRF	55922	broad.mit.edu	37	X	118724734	118724734	+	Silent	SNP	A	A	G			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:118724734A>G	ENST00000371527.1	-	2	1306	c.654T>C	c.(652-654)taT>taC	p.Y218Y	NKRF_ENST00000487600.1_Intron|NKRF_ENST00000542113.1_Silent_p.Y233Y|NKRF_ENST00000304449.5_Silent_p.Y218Y	NM_001173488.1	NP_001166959.1	O15226	NKRF_HUMAN	NFKB repressing factor	218	Active repression domain.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|double-stranded RNA binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(3)|skin(1)|urinary_tract(1)	30						TTAAAGGAGCATATATATACT	0.328000													20	91					0	0	1	0	0
ZNF250	58500	broad.mit.edu	37	8	146107175	146107175	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr8:146107175C>T	ENST00000292579.7	-	6	1524	c.1408G>A	c.(1408-1410)Gag>Aag	p.E470K	ZNF250_ENST00000342660.6_Intron|ZNF250_ENST00000417550.2_Missense_Mutation_p.E465K|ZNF250_ENST00000543949.1_Intron	NM_001109689.3|NM_021061.4	NP_001103159.1|NP_066405.1	P15622	ZN250_HUMAN	zinc finger protein 250	470					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(2)|lung(8)|skin(1)	15	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;2.53e-38)|OV - Ovarian serous cystadenocarcinoma(54;4.07e-38)|all cancers(56;2.27e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.0654)		TGGATTCTCTCATGCTGGATC	0.557000													4	29					0	0	1	0	0
POLQ	10721	broad.mit.edu	37	3	121155015	121155015	+	Silent	SNP	G	G	A			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr3:121155015G>A	ENST00000264233.5	-	28	7625	c.7497C>T	c.(7495-7497)ttC>ttT	p.F2499F		NM_199420.3	NP_955452.3	O75417	DPOLQ_HUMAN	polymerase (DNA directed), theta	2499					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(55)|ovary(5)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	120				GBM - Glioblastoma multiforme(114;0.0915)		CATGGGATTTGAAGGTTGAGT	0.413000								DNA polymerases (catalytic subunits)					19	58					0	0	1	0	0
KIF27	55582	broad.mit.edu	37	9	86498900	86498900	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr9:86498900G>C	ENST00000297814.2	-	10	2416	c.2273C>G	c.(2272-2274)tCt>tGt	p.S758C	KIF27_ENST00000376347.1_Missense_Mutation_p.S149C|KIF27_ENST00000413982.1_Missense_Mutation_p.S758C|KIF27_ENST00000334204.2_Missense_Mutation_p.S758C	NM_017576.1	NP_060046.1	Q86VH2	KIF27_HUMAN	kinesin family member 27	758					cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(7)|lung(17)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	43						TACTTTCAAAGAATACTGCTT	0.323000													18	62					0	0	1	0	0
SEMA4A	64218	broad.mit.edu	37	1	156144686	156144686	+	Frame_Shift_Del	DEL	C	C	-			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr1:156144686delC	ENST00000368285.3	+	12	1656	c.1389delC	c.(1387-1389)ttcfs	p.F463fs	SEMA4A_ENST00000355014.2_Frame_Shift_Del_p.F463fs|SEMA4A_ENST00000487358.1_3'UTR|SEMA4A_ENST00000368286.2_Frame_Shift_Del_p.F331fs|SEMA4A_ENST00000368282.1_Frame_Shift_Del_p.F463fs|SEMA4A_ENST00000368284.1_Frame_Shift_Del_p.F331fs	NM_001193300.1|NM_022367.3	NP_001180229.1|NP_071762.2	Q9H3S1	SEM4A_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A	463	Sema.				axon guidance	integral to membrane|plasma membrane	receptor activity			breast(1)|ovary(2)|skin(2)	5	Hepatocellular(266;0.158)					TTCAGCTGTTCCCTGACCCTG	0.607													13	105	---	---	---	---					
LINC01158	100506421	broad.mit.edu	37	2	105440927	105440929	+	RNA	DEL	TGG	TGG	-			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:105440927_105440929delTGG	ENST00000458253.1	-	0	147				AC018730.1_ENST00000454729.1_RNA|AC018730.1_ENST00000443988.1_RNA|AC018730.1_ENST00000447876.1_RNA|AC018730.1_ENST00000413121.1_RNA																							gtggtggtgatggtggtggtggt	0.591													5	3	---	---	---	---					
ACVR2A	92	broad.mit.edu	37	2	148657415	148657415	+	Frame_Shift_Del	DEL	G	G	-			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr2:148657415delG	ENST00000241416.7	+	4	1112	c.476delG	c.(475-477)tggfs	p.W159fs	ACVR2A_ENST00000535787.1_Frame_Shift_Del_p.W51fs|AC009480.3_ENST00000402410.2_RNA|ACVR2A_ENST00000404590.1_Frame_Shift_Del_p.W159fs	NM_001278579.1|NM_001278580.1|NM_001616.3	NP_001265508.1|NP_001265509.1|NP_001607.1	P27037	AVR2A_HUMAN	activin A receptor, type IIA	159					activin receptor signaling pathway|BMP signaling pathway|positive regulation of activin receptor signaling pathway|positive regulation of bone mineralization|positive regulation of erythrocyte differentiation|positive regulation of osteoblast differentiation|positive regulation of protein phosphorylation	cytoplasm|inhibin-betaglycan-ActRII complex|integral to plasma membrane	ATP binding|coreceptor activity|inhibin beta-A binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|transforming growth factor beta receptor activity	p.W159L(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(5)|large_intestine(14)|liver(1)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(8)	45				BRCA - Breast invasive adenocarcinoma(221;0.0969)		TGTGCATTTTGGGTGTACAGG	0.398													9	135	---	---	---	---					
ADH1C	126	broad.mit.edu	37	4	100261040	100261041	+	RNA	INS	-	-	A	rs138827617	by1000genomes	TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr4:100261040_100261041insA	ENST00000515683.1	-	0	1316					NM_000669.3	NP_000660.1	P00326	ADH1G_HUMAN	alcohol dehydrogenase 1C (class I), gamma polypeptide						ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|zinc ion binding								OV - Ovarian serous cystadenocarcinoma(123;1.08e-07)	Fomepizole(DB01213)|NADH(DB00157)	AGTGCTTTCACAAAAAAAATCA	0.327													5	3	---	---	---	---					
DND1	373863	broad.mit.edu	37	5	140052285	140052285	+	Frame_Shift_Del	DEL	T	T	-			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr5:140052285delT	ENST00000542735.1	-	3	392	c.349delA	c.(349-351)acgfs	p.T117fs		NM_194249.2	NP_919225.1	Q8IYX4	DND1_HUMAN	DND microRNA-mediated repression inhibitor 1	117	RRM 1.				multicellular organismal development|negative regulation of gene silencing by miRNA	cytoplasm|nucleus	AU-rich element binding|nucleotide binding	p.T117fs*24(1)		central_nervous_system(1)|prostate(4)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTGTGCAGCGTGGCGATGGCG	0.682													6	9	---	---	---	---					
QKI	9444	broad.mit.edu	37	6	163984678	163984680	+	In_Frame_Del	DEL	CTA	CTA	-			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr6:163984678_163984680delCTA	ENST00000361752.3	+	6	1412_1414	c.861_863delCTA	c.(859-864)ccctat>cct	p.Y288del	QKI_ENST00000361195.2_In_Frame_Del_p.Y280del|QKI_ENST00000275262.7_In_Frame_Del_p.Y288del|QKI_ENST00000392127.2_In_Frame_Del_p.Y288del|QKI_ENST00000424802.3_In_Frame_Del_p.Y280del|QKI_ENST00000453779.2_In_Frame_Del_p.Y288del	NM_006775.2|NM_206853.2|NM_206854.2|NM_206855.2	NP_006766.1|NP_996735.1|NP_996736.1|NP_996737.1	Q96PU8	QKI_HUMAN	QKI, KH domain containing, RNA binding	288					mRNA processing|mRNA transport|regulation of translation|RNA splicing	cytoplasm|nucleus|plasma membrane	RNA binding|SH3 domain binding			central_nervous_system(1)|endometrium(2)|large_intestine(13)|lung(5)|ovary(1)|prostate(3)|urinary_tract(2)	27		Breast(66;5e-05)|Prostate(117;0.0235)|all_neural(5;0.0416)|Ovarian(120;0.0448)|Glioma(2;0.203)		all cancers(1;4.4e-46)|OV - Ovarian serous cystadenocarcinoma(33;6.91e-23)|GBM - Glioblastoma multiforme(1;2.94e-19)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|Kidney(3;0.000199)|KIRC - Kidney renal clear cell carcinoma(3;0.000234)		TCTATACACCCTATGAGTACCCC	0.468													25	100	---	---	---	---					
CCT6P1	643253	broad.mit.edu	37	7	65222951	65222951	+	RNA	DEL	T	T	-			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:65222951delT	ENST00000442266.1	+	0	561																											TTTCTGTAACTTTTTTTTTTT	0.323													3	6	---	---	---	---					
RELN	5649	broad.mit.edu	37	7	103202034	103202035	+	Frame_Shift_Ins	INS	-	-	T			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr7:103202034_103202035insT	ENST00000428762.1	-	36	5632_5633	c.5473_5474insA	c.(5473-5475)aggfs	p.R1825fs	RELN_ENST00000343529.5_Frame_Shift_Ins_p.R1825fs|RELN_ENST00000424685.2_Frame_Shift_Ins_p.R1825fs	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	1825					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity	p.R1825G(1)		NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CAGATTCCCCCTCTCTGCACCA	0.411													46	68	---	---	---	---					
ANKRD20A1	84210	broad.mit.edu	37	9	67934791	67934794	+	Frame_Shift_Del	DEL	AAAG	AAAG	-			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr9:67934791_67934794delAAAG	ENST00000377477.2	+	4	673_676	c.561_564delAAAG	c.(559-564)aaaaagfs	p.KK187fs		NM_032250.3	NP_115626.2			ankyrin repeat domain 20 family, member A1											kidney(1)|large_intestine(4)|lung(5)|urinary_tract(1)	11						TTTTATTGAAAAAGAAAGCAAGTT	0.309													3	4	---	---	---	---					
CCL17	6361	broad.mit.edu	37	16	57447877	57447879	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr16:57447877_57447879delCCT	ENST00000219244.4	+	2	162_164	c.33_35delCCT	c.(31-36)accctc>acc	p.L14del		NM_002987.2	NP_002978.1	Q92583	CCL17_HUMAN	chemokine (C-C motif) ligand 17	14					cell-cell signaling|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response|multicellular organismal development	extracellular space	chemokine activity			breast(1)|endometrium(1)|lung(2)|ovary(1)	5						CCCTGGTCACCCTCCTCCTGGGG	0.660													6	9	---	---	---	---					
C16orf74	404550	broad.mit.edu	37	16	85743879	85743881	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr16:85743879_85743881delGCT	ENST00000602583.1	-	1	575_577	c.25_27delAGC	c.(25-27)agcdel	p.S9del	C16orf74_ENST00000602758.1_Intron|C16orf74_ENST00000602719.1_In_Frame_Del_p.S21del|C16orf74_ENST00000602675.1_5'UTR|C16orf74_ENST00000602766.1_5'UTR|C16orf74_ENST00000284245.4_In_Frame_Del_p.S21del|C16orf74_ENST00000602914.1_Intron			Q96GX8	CP074_HUMAN	chromosome 16 open reading frame 74	21																	CCTCGTCGTGGCTGCTGCTGCTG	0.635													3	6	---	---	---	---					
EPOR	2057	broad.mit.edu	37	19	11489438	11489440	+	In_Frame_Del	DEL	TCT	TCT	-			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:11489438_11489440delTCT	ENST00000592375.2	-	7	946_948	c.842_844delAGA	c.(841-846)aagatc>atc	p.K281del	EPOR_ENST00000222139.6_In_Frame_Del_p.K281del			P19235	EPOR_HUMAN	erythropoietin receptor	281						extracellular region|integral to plasma membrane	erythropoietin receptor activity|identical protein binding			endometrium(1)|lung(2)|ovary(1)|urinary_tract(1)	5					Darbepoetin alfa(DB00012)|Epoetin alfa(DB00016)	CCAGGCCAGATCTTCTGCTTCAG	0.517													11	76	---	---	---	---					
ZNF724P	440519	broad.mit.edu	37	19	23405454	23405454	+	Frame_Shift_Del	DEL	C	C	-			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:23405454delC	ENST00000418100.1	-	4	1710	c.1593delG	c.(1591-1593)gagfs	p.E531fs																	endometrium(3)|kidney(1)|lung(2)|ovary(2)	8						TGTAGGGTTTCTCTCCAGCAT	0.363													10	60	---	---	---	---					
FCGBP	8857	broad.mit.edu	37	19	40376912	40376912	+	Frame_Shift_Del	DEL	G	G	-			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:40376912delG	ENST00000221347.6	-	24	11517	c.11510delC	c.(11509-11511)ccgfs	p.P3838fs	FCGBP_ENST00000595713.1_5'UTR	NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	3838	VWFD 9.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GCTCCCCGGCGGGCAGGTGGG	0.657													29	34	---	---	---	---					
ZNF285	26974	broad.mit.edu	37	19	44891852	44891853	+	Frame_Shift_Del	DEL	GA	GA	-			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:44891852_44891853delGA	ENST00000330997.4	-	4	618_619	c.554_555delTC	c.(553-555)ctcfs	p.L185fs	CTC-512J12.6_ENST00000588212.1_Intron|ZNF285_ENST00000591679.1_Frame_Shift_Del_p.L192fs|ZNF285_ENST00000544719.2_Frame_Shift_Del_p.L185fs	NM_152354.3	NP_689567.3			zinc finger protein 285											breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|prostate(5)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	44						AGGTCCAACTGAGGCTGTCATC	0.455													19	198	---	---	---	---					
ZNF544	27300	broad.mit.edu	37	19	58773128	58773128	+	Frame_Shift_Del	DEL	G	G	-			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chr19:58773128delG	ENST00000269829.4	+	7	1630	c.1156delG	c.(1156-1158)gggfs	p.G386fs	ZNF544_ENST00000595981.1_Intron|ZNF544_ENST00000599953.1_Frame_Shift_Del_p.G244fs|ZNF544_ENST00000600044.1_Frame_Shift_Del_p.G358fs|CTD-3138B18.5_ENST00000597230.1_RNA|CTD-3138B18.4_ENST00000600029.1_Intron|ZNF544_ENST00000415203.2_Frame_Shift_Del_p.G358fs|ZNF544_ENST00000596929.1_Intron|ZNF544_ENST00000599227.1_3'UTR|ZNF544_ENST00000596652.1_Frame_Shift_Del_p.G386fs|ZNF544_ENST00000600220.1_Frame_Shift_Del_p.G358fs|ZNF544_ENST00000596825.1_3'UTR	NM_014480.2	NP_055295.2	Q6NX49	ZN544_HUMAN	zinc finger protein 544	386					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|pancreas(1)|skin(1)|urinary_tract(1)	18		all_cancers(17;4.17e-12)|all_epithelial(17;1.25e-08)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.17)|GBM - Glioblastoma multiforme(193;0.018)		TACTCAGTGTGGGAAATCTTT	0.463													37	116	---	---	---	---					
KDM6A	7403	broad.mit.edu	37	X	44894227	44894227	+	Frame_Shift_Del	DEL	G	G	-			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:44894227delG	ENST00000377967.4	+	7	657	c.616delG	c.(616-618)gaafs	p.E206fs	KDM6A_ENST00000382899.4_Frame_Shift_Del_p.E206fs|KDM6A_ENST00000536777.1_Frame_Shift_Del_p.E206fs|KDM6A_ENST00000543216.1_Frame_Shift_Del_p.E206fs	NM_021140.2	NP_066963.2	O15550	KDM6A_HUMAN	lysine (K)-specific demethylase 6A	206					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0(12)|p.0?(6)|p.?(1)		NS(1)|breast(7)|central_nervous_system(27)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(24)|kidney(24)|large_intestine(9)|liver(1)|lung(21)|oesophagus(11)|pancreas(2)|prostate(5)|skin(1)|soft_tissue(1)|urinary_tract(29)	170						GTCCAATGCTGAAAGTAAGTA	0.338			"""D, N, F, S"""		"""renal, oesophageal SCC, MM"""								24	103	---	---	---	---					
KDM6A	7403	broad.mit.edu	37	X	44922690	44922702	+	Frame_Shift_Del	DEL	GGTACGATCTACT	GGTACGATCTACT	-			TCGA-ZF-AA51-01A-21D-A391-08	TCGA-ZF-AA51-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d04546e-a5a0-412d-8d2d-0534be81c44b	0ecb9d0e-a9ca-40e1-bff6-fd3a754b1f5f	g.chrX:44922690_44922702delGGTACGATCTACT	ENST00000377967.4	+	16	1592_1604	c.1551_1563delGGTACGATCTACT	c.(1549-1563)caggtacgatctactfs	p.QVRST517fs	KDM6A_ENST00000382899.4_Frame_Shift_Del_p.QVRST524fs|KDM6A_ENST00000536777.1_Frame_Shift_Del_p.QVRST472fs|KDM6A_ENST00000543216.1_Frame_Shift_Del_p.QVRST438fs	NM_021140.2	NP_066963.2	O15550	KDM6A_HUMAN	lysine (K)-specific demethylase 6A	517					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0?(6)|p.0(2)|p.R519*(1)		NS(1)|breast(7)|central_nervous_system(27)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(24)|kidney(24)|large_intestine(9)|liver(1)|lung(21)|oesophagus(11)|pancreas(2)|prostate(5)|skin(1)|soft_tissue(1)|urinary_tract(29)	170						GAGTTGCACAGGTACGATCTACTGGAATTCCTA	0.465			"""D, N, F, S"""		"""renal, oesophageal SCC, MM"""								20	63	---	---	---	---