Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PHACTR2	9749	broad.mit.edu	37	6	144098521	144098521	+	Splice_Site	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:144098521G>C	ENST00000427704.2	+	9	1742		c.e9+1		PHACTR2_ENST00000367584.4_Splice_Site|PHACTR2_ENST00000367582.3_Splice_Site|PHACTR2_ENST00000305766.6_Splice_Site|PHACTR2_ENST00000440869.2_Splice_Site	NM_001100166.1|NM_014721.2	NP_001093636.1|NP_055536.2	O75167	PHAR2_HUMAN	phosphatase and actin regulator 2								actin binding|protein phosphatase inhibitor activity			NS(3)|breast(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	30				OV - Ovarian serous cystadenocarcinoma(155;1.58e-05)|GBM - Glioblastoma multiforme(68;0.0386)		ATCCTAAAACGTGAGTATTCT	0.358000													8	12					0	0	1	0	0
KANSL1	284058	broad.mit.edu	37	17	44115979	44115979	+	Silent	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr17:44115979C>T	ENST00000262419.6	-	10	2936	c.2466G>A	c.(2464-2466)ttG>ttA	p.L822L	KANSL1_ENST00000572904.1_Silent_p.L822L|KANSL1_ENST00000432791.1_Silent_p.L822L|KANSL1_ENST00000393476.3_Silent_p.L116L|KANSL1_ENST00000574590.1_Silent_p.L822L|KANSL1_ENST00000575318.1_Silent_p.L759L	NM_001193466.1	NP_001180395	Q7Z3B3	K1267_HUMAN	KAT8 regulatory NSL complex subunit 1	822						MLL1 complex	protein binding										GCTGTCGCACCAAGGGACTGT	0.557000													8	41					0	0	1	0	0
COBLL1	22837	broad.mit.edu	37	2	165555944	165555944	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr2:165555944A>G	ENST00000375458.2	-	10	1747	c.1526T>C	c.(1525-1527)tTg>tCg	p.L509S	COBLL1_ENST00000392717.2_Missense_Mutation_p.L586S|COBLL1_ENST00000194871.6_Missense_Mutation_p.L614S|COBLL1_ENST00000342193.4_Missense_Mutation_p.L548S|COBLL1_ENST00000409184.3_Missense_Mutation_p.L547S	NM_001278460.1|NM_001278461.1	NP_001265389.1|NP_001265390.1	Q53SF7	COBL1_HUMAN	cordon-bleu WH2 repeat protein-like 1	586										central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(12)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	47						CAACGACTTCAAGTTTCTTAT	0.348000													28	106					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145302714	145302714	+	Silent	SNP	A	A	G	rs9424867		TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr1:145302714A>G	ENST00000342960.5	+	8	1187	c.1152A>G	c.(1150-1152)ttA>ttG	p.L384L	NBPF10_ENST00000369339.3_Silent_p.L113L|NBPF10_ENST00000369338.1_Silent_p.L113L|RP11-458D21.5_ENST00000468030.1_3'UTR	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	384								p.L113L(3)|p.L384L(3)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		AGGAGAAGTTACGGGAAGGGA	0.527000													4	209					0	0	1	0	0
ADAMTS1	9510	broad.mit.edu	37	21	28210348	28210348	+	Silent	SNP	T	T	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr21:28210348T>C	ENST00000284984.3	-	9	2908	c.2454A>G	c.(2452-2454)aaA>aaG	p.K818K		NM_006988.3	NP_008919.3	Q9UHI8	ATS1_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 1		Spacer.				integrin-mediated signaling pathway|negative regulation of cell proliferation|proteolysis		heparin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(20)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	42		Breast(209;0.000962)		Lung(58;0.215)		TCAAGGGCTCTTTGAGAGGGC	0.448000													15	40					0	0	1	0	0
MYOM1	8736	broad.mit.edu	37	18	3067313	3067313	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr18:3067313C>T	ENST00000400569.3	-	38	5338	c.5005G>A	c.(5005-5007)Gag>Aag	p.E1669K	MYOM1_ENST00000261606.7_Missense_Mutation_p.E1573K|MYOM1_ENST00000356443.4_Missense_Mutation_p.E1669K			P52179	MYOM1_HUMAN	myomesin 1	1669						striated muscle myosin thick filament	structural constituent of muscle			NS(2)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(20)|ovary(4)|pancreas(1)|prostate(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						ATCCTCGCCTCCTCCTCTGGG	0.607000													6	25					0	0	1	0	0
LPAL2	80350	broad.mit.edu	37	6	160905249	160905249	+	RNA	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:160905249G>C	ENST00000335388.5	-	0	878					NR_028092.1															large_intestine(1)|lung(4)	5		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.214)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)		ACAGGATCTGGATTCCTGCAG	0.507000													10	50					0	0	1	0	0
C3orf17	25871	broad.mit.edu	37	3	112732136	112732136	+	Silent	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr3:112732136G>A	ENST00000314400.5	-	4	647	c.456C>T	c.(454-456)tgC>tgT	p.C152C	C3orf17_ENST00000383675.2_Intron|C3orf17_ENST00000393857.2_Silent_p.C16C	NM_015412.3	NP_056227.2	Q6NW34	CC017_HUMAN	chromosome 3 open reading frame 17	152						integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(2)|lung(6)|prostate(2)|skin(1)	13						TTTTGCAGCAGCAGTCCAACA	0.388000													19	36					0	0	1	0	0
ATR	545	broad.mit.edu	37	3	142222235	142222235	+	Missense_Mutation	SNP	T	T	C	rs143806447	byFrequency	TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr3:142222235T>C	ENST00000350721.4	-	30	5378	c.5257A>G	c.(5257-5259)Atc>Gtc	p.I1753V	ATR_ENST00000383101.3_Missense_Mutation_p.I1689V	NM_001184.3	NP_001175.2	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related	1753	FAT.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			NS(1)|breast(10)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|liver(2)|lung(45)|ovary(3)|skin(10)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(4)	122						ACCTGAGTGATAACAGTAGAC	0.303000								Other conserved DNA damage response genes					92	80					0	0	1	0	0
DNAJA4	55466	broad.mit.edu	37	15	78557111	78557111	+	Silent	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr15:78557111G>A	ENST00000394855.3	+	2	321	c.93G>A	c.(91-93)gtG>gtA	p.V31V	DNAJA4_ENST00000394852.3_Silent_p.V2V|DNAJA4_ENST00000343789.3_Silent_p.V2V|DNAJA4_ENST00000489435.2_Silent_p.V31V	NM_018602.3	NP_061072.3	Q8WW22	DNJA4_HUMAN	DnaJ (Hsp40) homolog, subfamily A, member 4	2	J.				protein folding|response to heat	membrane	ATP binding|heat shock protein binding|metal ion binding|unfolded protein binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|skin(1)	8						ACAAGATGGTGAAGGAGACCC	0.721000													6	7					0	0	1	0	0
PCDH10	57575	broad.mit.edu	37	4	134071766	134071766	+	Silent	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr4:134071766C>T	ENST00000264360.5	+	1	1297	c.471C>T	c.(469-471)cgC>cgT	p.R157R		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10		Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		ACTCCTTGCGCGACTACGAGA	0.622000													6	80					0	0	1	0	0
DFFA	1676	broad.mit.edu	37	1	10532575	10532575	+	Translation_Start_Site	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr1:10532575C>A	ENST00000377038.3	-	0	8					NM_004401.2	NP_004392.1	O00273	DFFA_HUMAN	DNA fragmentation factor, 45kDa, alpha polypeptide						DNA fragmentation involved in apoptotic nuclear change|intracellular signal transduction|negative regulation of apoptosis	cytosol|mitochondrion|nucleoplasm|plasma membrane	deoxyribonuclease activity|identical protein binding			large_intestine(3)|lung(2)	5	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.25e-07)|COAD - Colon adenocarcinoma(227;7.25e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000296)|Kidney(185;0.00074)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0487)		AGCGGCGGTCCTTCTACTCGA	0.632000													6	9					0.0215528	0.0225769	1	1	0
MYH13	8735	broad.mit.edu	37	17	10219292	10219292	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr17:10219292G>C	ENST00000418404.3	-	27	3952	c.3789C>G	c.(3787-3789)atC>atG	p.I1263M	RP11-401O9.4_ENST00000609088.1_RNA|MYH13_ENST00000252172.4_Missense_Mutation_p.I1263M			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	1263					muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						CCTTGGCTTTGATTTCACTAA	0.443000													3	44					0	0	1	0	0
DOPEY2	9980	broad.mit.edu	37	21	37605253	37605253	+	Silent	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr21:37605253G>A	ENST00000399151.3	+	15	2587	c.2502G>A	c.(2500-2502)aaG>aaA	p.K834K		NM_005128.2	NP_005119.2	Q9Y3R5	DOP2_HUMAN	dopey family member 2	834					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(6)|lung(25)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						TTGAAGACAAGATGAAACGCT	0.498000													55	76					0	0	1	0	0
SETD6	79918	broad.mit.edu	37	16	58552690	58552690	+	Silent	SNP	T	T	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr16:58552690T>C	ENST00000394266.4	+	9	1028	c.972T>C	c.(970-972)gaT>gaC	p.D324D	SETD6_ENST00000219315.4_Silent_p.D393D|SETD6_ENST00000310682.2_Silent_p.D369D			Q8TBK2	SETD6_HUMAN	SET domain containing 6	393					negative regulation of NF-kappaB transcription factor activity|peptidyl-lysine monomethylation|regulation of inflammatory response	nucleus	NF-kappaB binding|protein-lysine N-methyltransferase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|skin(1)	7						GGGGAGATGATAAAAGGGAAG	0.473000													16	34					0	0	1	0	0
RNASEL	6041	broad.mit.edu	37	1	182554725	182554725	+	Missense_Mutation	SNP	G	G	C	rs145787003		TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr1:182554725G>C	ENST00000367559.3	-	2	1470	c.1217C>G	c.(1216-1218)tCt>tGt	p.S406C	RNASEL_ENST00000444138.1_Missense_Mutation_p.S406C|RNASEL_ENST00000539397.1_Missense_Mutation_p.S406C	NM_021133.3	NP_066956.1	Q05823	RN5A_HUMAN	ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)	406	Protein kinase.		S -> F.		mRNA processing|response to virus|type I interferon-mediated signaling pathway	mitochondrion	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|metal ion binding|protein kinase activity|RNA binding			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(9)|ovary(4)|prostate(1)|stomach(1)|urinary_tract(1)	27						TTGCAGACAAGAGACTTCCCG	0.532000													31	53					0	0	1	0	0
SLC17A1	6568	broad.mit.edu	37	6	25811918	25811918	+	Silent	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:25811918C>G	ENST00000244527.4	-	9	1093	c.978G>C	c.(976-978)ctG>ctC	p.L326L	SLC17A1_ENST00000476801.1_Silent_p.L326L|SLC17A1_ENST00000468082.1_Silent_p.L272L|SLC17A1_ENST00000427328.1_Silent_p.L272L	NM_005074.3	NP_005065.2	Q14916	NPT1_HUMAN	solute carrier family 17 (organic anion transporter), member 1	326					sodium ion transport|urate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent phosphate transmembrane transporter activity|symporter activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(14)|ovary(3)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	36						TATTCCTGGTCAGGAAGAAGT	0.453000													12	38					0	0	1	0	0
TSHZ3	57616	broad.mit.edu	37	19	31769550	31769550	+	Silent	SNP	C	C	T	rs148943651		TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr19:31769550C>T	ENST00000240587.4	-	2	1476	c.1149G>A	c.(1147-1149)tcG>tcA	p.S383S		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	383					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					TCAGGATCTGCGACTTCCGGG	0.547000													74	127					0	0	1	0	0
MESP1	55897	broad.mit.edu	37	15	90293764	90293764	+	Silent	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr15:90293764C>T	ENST00000300057.4	-	1	777	c.699G>A	c.(697-699)gcG>gcA	p.A233A	MESP1_ENST00000559894.1_Intron	NM_018670.3	NP_061140.1	Q9BRJ9	MESP1_HUMAN	mesoderm posterior 1 homolog (mouse)	233					cardiac atrium formation|cardiac cell fate determination|cardiac vascular smooth muscle cell differentiation|cardiac ventricle formation|cardioblast anterior-lateral migration|cardioblast migration to the midline involved in heart field formation|endothelial cell differentiation|gastrulation|growth involved in heart morphogenesis|heart looping|lateral mesoderm development|negative regulation of endodermal cell fate specification|negative regulation of mesodermal cell fate specification|negative regulation of transcription, DNA-dependent|neurogenesis|Notch signaling pathway|positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway|positive regulation of hepatocyte differentiation|positive regulation of Notch signaling pathway|positive regulation of striated muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|secondary heart field specification|sinoatrial node cell differentiation|sinus venosus morphogenesis		sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			NS(1)|kidney(1)	2	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)			TTGGCTCCATCGCCTGCCCTT	0.761000													5	6					0	0	1	0	0
TM2D2	83877	broad.mit.edu	37	8	38852965	38852965	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr8:38852965C>G	ENST00000412303.1	-	2	452	c.58G>C	c.(58-60)Gac>Cac	p.D20H	TM2D2_ENST00000522434.1_Intron|TM2D2_ENST00000456397.2_Intron|TM2D2_ENST00000456845.2_Missense_Mutation_p.D20H|TM2D2_ENST00000397070.2_Missense_Mutation_p.D20H	NM_001024380.1|NM_001024381.1|NM_031940.3	NP_001019551.1|NP_001019552.1|NP_114146.3	Q9BX73	TM2D2_HUMAN	TM2 domain containing 2	0						integral to membrane				breast(1)|endometrium(1)|large_intestine(2)|lung(2)	6		all_lung(54;0.00338)|Lung NSC(58;0.0133)|Hepatocellular(245;0.0153)	LUSC - Lung squamous cell carcinoma(45;1.5e-07)			ATCATACGGTCTTTGCAAATC	0.423000													35	58					0	0	1	0	0
HUWE1	10075	broad.mit.edu	37	X	53602629	53602629	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chrX:53602629C>T	ENST00000342160.3	-	44	6461	c.6004G>A	c.(6004-6006)Gat>Aat	p.D2002N	HUWE1_ENST00000262854.6_Missense_Mutation_p.D2002N			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	2002					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						GACTGCGTATCAAAGTCACTG	0.453000													7	20					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43945692	43945692	+	Silent	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr12:43945692G>C	ENST00000389420.3	-	1	32	c.33C>G	c.(31-33)ctC>ctG	p.L11L	ADAMTS20_ENST00000553158.1_Silent_p.L11L	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	11						proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		AGAGATGGTAGAGCAGCCCAG	0.647000													8	39					0	0	1	0	0
SLC1A3	6507	broad.mit.edu	37	5	36677103	36677103	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr5:36677103G>A	ENST00000265113.4	+	6	1153	c.677G>A	c.(676-678)cGa>cAa	p.R226Q	CTD-2353F22.1_ENST00000510740.1_RNA|SLC1A3_ENST00000381918.3_Missense_Mutation_p.R226Q	NM_004172.4	NP_004163.3	P43003	EAA1_HUMAN	solute carrier family 1 (glial high affinity glutamate transporter), member 3	226					D-aspartate import|L-glutamate import|neurotransmitter uptake	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity	p.R226Q(2)|p.R226L(2)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(23)|skin(1)	41	all_lung(31;0.000245)		Epithelial(62;0.0444)|Lung(74;0.111)|all cancers(62;0.128)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)		L-Glutamic Acid(DB00142)	ACTCTTACCCGAATCACAGAG	0.488000													17	85					0	0	1	0	0
CNKSR1	10256	broad.mit.edu	37	1	26507320	26507320	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr1:26507320A>G	ENST00000361530.6	+	3	470	c.325A>G	c.(325-327)Att>Gtt	p.I109V	CNKSR1_ENST00000480348.2_3'UTR|CNKSR1_ENST00000531191.1_5'UTR|CNKSR1_ENST00000374253.5_Missense_Mutation_p.I109V			Q969H4	CNKR1_HUMAN	connector enhancer of kinase suppressor of Ras 1	109	CRIC.				Rho protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cell cortex|cell-cell junction	protein binding, bridging			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(8)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	28		Colorectal(325;3.46e-05)|all_lung(284;0.000116)|Lung NSC(340;0.000154)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.72e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|BRCA - Breast invasive adenocarcinoma(304;0.000959)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00823)|READ - Rectum adenocarcinoma(331;0.0649)		CAAGACCCCTATTGATGTCCT	0.582000													15	40					0	0	1	0	0
MED13	9969	broad.mit.edu	37	17	60088210	60088210	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr17:60088210C>G	ENST00000397786.2	-	9	1744	c.1668G>C	c.(1666-1668)caG>caC	p.Q556H		NM_005121.2	NP_005112.2	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	556					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(4)|central_nervous_system(1)|endometrium(10)|kidney(24)|large_intestine(15)|liver(1)|lung(20)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						AATGTTGACTCTGAGGAGTTG	0.448000													26	87					0	0	1	0	0
BLNK	29760	broad.mit.edu	37	10	97987274	97987274	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr10:97987274C>T	ENST00000224337.5	-	5	394	c.253G>A	c.(253-255)Gtg>Atg	p.V85M	BLNK_ENST00000371176.2_Missense_Mutation_p.V85M|BLNK_ENST00000427367.2_Missense_Mutation_p.V85M|BLNK_ENST00000413476.2_Missense_Mutation_p.V85M	NM_013314.3	NP_037446.1	Q8WV28	BLNK_HUMAN	B-cell linker	85					B cell differentiation|humoral immune response|inflammatory response|intracellular signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity|transmembrane receptor protein tyrosine kinase adaptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|skin(2)|stomach(1)	14		Colorectal(252;0.083)		Epithelial(162;7.89e-08)|all cancers(201;2.27e-06)		GCGGGCATCACGTACATCTCT	0.597000													31	92					0	0	1	0	0
MYNN	55892	broad.mit.edu	37	3	169497252	169497252	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr3:169497252G>T	ENST00000349841.5	+	3	1626	c.963G>T	c.(961-963)atG>atT	p.M321I	MYNN_ENST00000356716.4_Missense_Mutation_p.M321I|RP11-362K14.5_ENST00000602342.1_RNA|MYNN_ENST00000392733.1_Missense_Mutation_p.M321I|MYNN_ENST00000544106.1_Missense_Mutation_p.M321I	NM_018657.4	NP_061127.1	Q9NPC7	MYNN_HUMAN	myoneurin	321						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16	all_cancers(22;9.55e-22)|all_epithelial(15;2.04e-26)|all_lung(20;5.05e-16)|Lung NSC(18;2.19e-15)|Ovarian(172;0.000223)|Breast(254;0.197)		Epithelial(2;4.03e-64)|all cancers(2;2.19e-58)|Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00676)			GAAGGCACATGAGAATACATA	0.453000													3	34					0.115264	0.117939	1	1	0
GTF3C2	2976	broad.mit.edu	37	2	27566208	27566208	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr2:27566208C>G	ENST00000359541.2	-	2	643	c.214G>C	c.(214-216)Gag>Cag	p.E72Q	GTF3C2_ENST00000264720.3_Missense_Mutation_p.E72Q			Q8WUA4	TF3C2_HUMAN	general transcription factor IIIC, polypeptide 2, beta 110kDa	72						transcription factor TFIIIC complex				central_nervous_system(4)|endometrium(6)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(2)	38	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTTTCCTGCTCTGGAGGGAGC	0.488000													46	151					0	0	1	0	0
GPD2	2820	broad.mit.edu	37	2	157435453	157435453	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr2:157435453C>G	ENST00000310454.6	+	14	2192	c.1820C>G	c.(1819-1821)tCt>tGt	p.S607C	GPD2_ENST00000540309.1_Intron|GPD2_ENST00000409125.4_Missense_Mutation_p.S380C|GPD2_ENST00000409674.1_Missense_Mutation_p.S607C|GPD2_ENST00000438166.2_Missense_Mutation_p.S607C	NM_001083112.2	NP_001076581.2	P43304	GPDM_HUMAN	glycerol-3-phosphate dehydrogenase 2 (mitochondrial)	607					cellular lipid metabolic process	glycerol-3-phosphate dehydrogenase complex|mitochondrial inner membrane	calcium ion binding|sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(1)|stomach(1)	22						GGCTATAAATCTCGATCAGAA	0.343000													3	70					0	0	1	0	0
SOX4	6659	broad.mit.edu	37	6	21596141	21596141	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:21596141C>G	ENST00000244745.1	+	1	2170	c.1376C>G	c.(1375-1377)tCg>tGg	p.S459W	SOX4_ENST00000543472.1_Missense_Mutation_p.S459W	NM_003107.2	NP_003098.1	Q06945	SOX4_HUMAN	SRY (sex determining region Y)-box 4	459					canonical Wnt receptor signaling pathway|cardiac ventricle formation|cellular response to glucose stimulus|DNA damage response, detection of DNA damage|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|glial cell development|glial cell proliferation|limb bud formation|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of protein export from nucleus|negative regulation of protein ubiquitination|neural tube formation|neuroepithelial cell differentiation|noradrenergic neuron differentiation|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|positive regulation of insulin secretion|positive regulation of N-terminal peptidyl-lysine acetylation|positive regulation of translation|pro-B cell differentiation|protein stabilization|skeletal system development|spinal cord motor neuron differentiation|sympathetic nervous system development|T cell differentiation	mitochondrion|nucleus	core promoter sequence-specific DNA binding|protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription coactivator activity			kidney(2)|lung(2)|prostate(1)|upper_aerodigestive_tract(1)	6	Ovarian(93;0.163)		all cancers(50;0.0751)|Epithelial(50;0.155)			GAGATGATCTCGGGAGACTGG	0.622000													3	6					0	0	1	0	0
SHPK	23729	broad.mit.edu	37	17	3527418	3527418	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr17:3527418G>C	ENST00000225519.3	-	3	520	c.418C>G	c.(418-420)Ctg>Gtg	p.L140V		NM_013276.2	NP_037408	Q9UHJ6	SHPK_HUMAN	sedoheptulokinase	140					carbohydrate metabolic process	cytoplasm	ATP binding|sedoheptulokinase activity			breast(1)|endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16				COAD - Colon adenocarcinoma(5;0.0828)		GGCTGGGGCAGAGAGGCCAGG	0.582000													3	31					0	0	1	0	0
OR2S2	56656	broad.mit.edu	37	9	35957169	35957169	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr9:35957169C>A	ENST00000341959.2	-	1	982	c.927G>T	c.(925-927)agG>agT	p.R309S		NM_019897.2	NP_063950.2	Q9NQN1	OR2S1_HUMAN	olfactory receptor, family 2, subfamily S, member 2	309					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(8)|ovary(1)|skin(1)|stomach(1)	17			LUSC - Lung squamous cell carcinoma(32;0.00613)|STAD - Stomach adenocarcinoma(86;0.194)			TCAGCAGTCTCCTCACAGCAG	0.502000													4	85					0.184627	0.186551	1	1	0
HIVEP2	3097	broad.mit.edu	37	6	143093773	143093773	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:143093773C>G	ENST00000367603.2	-	5	2845	c.2103G>C	c.(2101-2103)aaG>aaC	p.K701N	HIVEP2_ENST00000367604.1_Missense_Mutation_p.K701N|HIVEP2_ENST00000012134.2_Missense_Mutation_p.K701N	NM_006734.3	NP_006725.3	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer binding protein 2	701					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(4)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(19)|lung(35)|ovary(4)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	100				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		CCCCTACGCTCTTCTCTTTCC	0.512000													25	96					0	0	1	0	0
DNMT1	1786	broad.mit.edu	37	19	10291537	10291537	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr19:10291537G>C	ENST00000340748.4	-	3	377	c.142C>G	c.(142-144)Ctc>Gtc	p.L48V	DNMT1_ENST00000540357.1_Missense_Mutation_p.L48V|DNMT1_ENST00000359526.4_Missense_Mutation_p.L48V			P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1	48	Interaction with DMAP1.|Interaction with DNMT3A.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			breast(5)|endometrium(8)|kidney(5)|large_intestine(21)|lung(11)|ovary(2)|pancreas(1)|prostate(10)|skin(5)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	TCGTGCAAGAGATTCAATTTC	0.368000													6	24					0	0	1	0	0
POT1	25913	broad.mit.edu	37	7	124475437	124475437	+	Silent	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr7:124475437C>T	ENST00000357628.3	-	15	1999	c.1401G>A	c.(1399-1401)tcG>tcA	p.S467S	POT1_ENST00000393329.1_Silent_p.S336S	NM_015450.2	NP_056265.2	Q9NUX5	POTE1_HUMAN	protection of telomeres 1	467					DNA duplex unwinding|negative regulation of telomere maintenance via telomerase|positive regulation of DNA strand elongation|positive regulation of helicase activity|positive regulation of telomerase activity|positive regulation of telomere maintenance via telomerase|telomere capping|telomere formation via telomerase|telomere maintenance via telomerase	nuclear telomere cap complex|nucleoplasm	DEAD/H-box RNA helicase binding|single-stranded telomeric DNA binding|telomerase inhibitor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(4)|liver(1)|lung(23)|ovary(1)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	47						TAAACTTGTTCGAGAGTTTGC	0.358000													17	53					0	0	1	0	0
DSE	29940	broad.mit.edu	37	6	116720707	116720707	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:116720707G>T	ENST00000331677.3	+	3	738	c.294G>T	c.(292-294)tgG>tgT	p.W98C	DSE_ENST00000537543.1_Missense_Mutation_p.W117C|DSE_ENST00000540275.1_3'UTR|DSE_ENST00000359564.2_Missense_Mutation_p.W98C|DSE_ENST00000452085.3_Missense_Mutation_p.W98C			Q9UL01	DSE_HUMAN	dermatan sulfate epimerase	98					dermatan sulfate biosynthetic process	endoplasmic reticulum|Golgi apparatus|integral to membrane	chondroitin-glucuronate 5-epimerase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(2)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35		all_cancers(87;0.00019)|all_epithelial(87;0.000416)|Ovarian(999;0.133)|Colorectal(196;0.234)		Epithelial(106;0.00915)|OV - Ovarian serous cystadenocarcinoma(136;0.0149)|GBM - Glioblastoma multiforme(226;0.0189)|all cancers(137;0.0262)		GTGCCCGCTGGAATGAAATTT	0.537000													9	29					0.0581538	0.0600097	1	1	0
UBR5	51366	broad.mit.edu	37	8	103293699	103293699	+	Silent	SNP	T	T	A	rs139611652		TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr8:103293699T>A	ENST00000520539.1	-	41	6351	c.5745A>T	c.(5743-5745)ggA>ggT	p.G1915G	UBR5_ENST00000521922.1_Silent_p.G1909G|UBR5_ENST00000220959.4_Silent_p.G1915G	NM_001282873.1|NM_015902.5	NP_001269802.1|NP_056986.2	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin 5	1915					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			NS(1)|breast(13)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(19)|liver(1)|lung(51)|ovary(6)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	124	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			TTAGGAAGTCTCCTCGTGCAG	0.403000													13	72					0	0	1	0	0
ALDH3B2	222	broad.mit.edu	37	11	67434384	67434384	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr11:67434384G>T	ENST00000349015.3	-	3	461	c.23C>A	c.(22-24)aCg>aAg	p.T8K	ALDH3B2_ENST00000531881.1_5'UTR|ALDH3B2_ENST00000530069.1_Missense_Mutation_p.T8K	NM_000695.3	NP_000686	P48448	AL3B2_HUMAN	aldehyde dehydrogenase 3 family, member B2	8					alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase	p.T8R(1)		central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|prostate(2)|stomach(1)|urinary_tract(1)	18					NADH(DB00157)	CACCAGGTTCGTGGACCGTGG	0.642000													3	31					0.150653	0.15286	1	1	0
ICAM3	3385	broad.mit.edu	37	19	10445852	10445852	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr19:10445852G>T	ENST00000589261.1	-	4	1128	c.596C>A	c.(595-597)gCc>gAc	p.A199D	ICAM3_ENST00000160262.5_Missense_Mutation_p.A276D			P32942	ICAM3_HUMAN	intercellular adhesion molecule 3	276					cell-cell adhesion|regulation of immune response	integral to plasma membrane	integrin binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|upper_aerodigestive_tract(2)	13			OV - Ovarian serous cystadenocarcinoma(20;6.13e-09)|Epithelial(33;9.69e-06)|all cancers(31;2.05e-05)			TGTGGCTGTGGCCGTTAGCGT	0.657000													5	153					0.217242	0.218594	1	1	0
TAOK2	9344	broad.mit.edu	37	16	29994547	29994547	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr16:29994547A>T	ENST00000308893.4	+	12	2197	c.1154A>T	c.(1153-1155)gAg>gTg	p.E385V	TAOK2_ENST00000543033.1_Missense_Mutation_p.E385V|TAOK2_ENST00000279394.3_Missense_Mutation_p.E385V|TAOK2_ENST00000416441.2_Missense_Mutation_p.E212V	NM_001252043.1|NM_016151.3	NP_001238972.1|NP_057235.2	Q9UL54	TAOK2_HUMAN	TAO kinase 2	385	Glu-rich.				actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(3)|skin(1)	22						gaggaggaggaggaagaggag	0.607000													6	65					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49679857	49679857	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr3:49679857G>C	ENST00000296452.4	+	3	904	c.790G>C	c.(790-792)Gag>Cag	p.E264Q		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	264					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GCCAGACCAAGAGAGATCTCG	0.697000													4	9					0	0	1	0	0
THADA	63892	broad.mit.edu	37	2	43801713	43801713	+	Silent	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr2:43801713G>C	ENST00000403856.1	-	12	1638	c.1491C>G	c.(1489-1491)ctC>ctG	p.L497L	THADA_ENST00000404790.1_Silent_p.L497L|THADA_ENST00000405006.4_Silent_p.L497L|THADA_ENST00000405975.2_Silent_p.L497L|THADA_ENST00000402360.2_Silent_p.L497L|THADA_ENST00000415080.2_Silent_p.L207L|THADA_ENST00000330266.7_Silent_p.L207L			Q6YHU6	THADA_HUMAN	thyroid adenoma associated	497							binding			breast(1)|endometrium(9)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	66		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				TGGTTTCCAAGAGGTCACTTG	0.413000													3	60					0	0	1	0	0
ATAD2B	54454	broad.mit.edu	37	2	24051785	24051785	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr2:24051785G>A	ENST00000238789.5	-	15	2096	c.1753C>T	c.(1753-1755)Cat>Tat	p.H585Y	ATAD2B_ENST00000474583.1_5'UTR	NM_001242338.1|NM_017552.2	NP_001229267.1|NP_060022.1	Q9ULI0	ATD2B_HUMAN	ATPase family, AAA domain containing 2B	585							ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCCCTGGTATGGATCTGTAAG	0.338000													4	38					0	0	1	0	0
LRRN1	57633	broad.mit.edu	37	3	3887975	3887975	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr3:3887975G>C	ENST00000319331.3	+	2	2411	c.1650G>C	c.(1648-1650)atG>atC	p.M550I	SUMF1_ENST00000534863.1_Intron	NM_020873.5	NP_065924.3	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1	550	Fibronectin type-III.					integral to membrane				NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|skin(1)|urinary_tract(2)	26				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		CCAATGTCATGACGTCAAACT	0.433000													52	222					0	0	1	0	0
C19orf53	28974	broad.mit.edu	37	19	13885342	13885342	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr19:13885342G>C	ENST00000588234.1	+	1	361	c.51G>C	c.(49-51)aaG>aaC	p.K17N		NM_014047.2	NP_054766.1	Q9UNZ5	L10K_HUMAN	chromosome 19 open reading frame 53	17										breast(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	6			OV - Ovarian serous cystadenocarcinoma(19;7.7e-24)|Epithelial(5;2.53e-19)			CAAAGAGTAAGACGGCAGCGG	0.662000													5	25					0	0	1	0	0
DSE	29940	broad.mit.edu	37	6	116720706	116720706	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:116720706G>C	ENST00000331677.3	+	3	737	c.293G>C	c.(292-294)tGg>tCg	p.W98S	DSE_ENST00000537543.1_Missense_Mutation_p.W117S|DSE_ENST00000540275.1_3'UTR|DSE_ENST00000359564.2_Missense_Mutation_p.W98S|DSE_ENST00000452085.3_Missense_Mutation_p.W98S			Q9UL01	DSE_HUMAN	dermatan sulfate epimerase	98					dermatan sulfate biosynthetic process	endoplasmic reticulum|Golgi apparatus|integral to membrane	chondroitin-glucuronate 5-epimerase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(2)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35		all_cancers(87;0.00019)|all_epithelial(87;0.000416)|Ovarian(999;0.133)|Colorectal(196;0.234)		Epithelial(106;0.00915)|OV - Ovarian serous cystadenocarcinoma(136;0.0149)|GBM - Glioblastoma multiforme(226;0.0189)|all cancers(137;0.0262)		AGTGCCCGCTGGAATGAAATT	0.542000													9	29					0	0	1	0	0
NRBP1	29959	broad.mit.edu	37	2	27662724	27662724	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr2:27662724C>T	ENST00000233557.3	+	12	1827	c.995C>T	c.(994-996)tCg>tTg	p.S332L	NRBP1_ENST00000379863.3_Missense_Mutation_p.S340L|NRBP1_ENST00000379852.3_Missense_Mutation_p.S332L			Q9UHY1	NRBP_HUMAN	nuclear receptor binding protein 1	332					ER to Golgi vesicle-mediated transport|gene expression|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cell cortex|endomembrane system|lamellipodium|membrane|nucleoplasm	ATP binding|protein homodimerization activity|protein kinase activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19	Acute lymphoblastic leukemia(172;0.155)					GAAGTGCCCTCGCTCAAACTC	0.522000													44	91					0	0	1	0	0
AP3B2	8120	broad.mit.edu	37	15	83335615	83335615	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr15:83335615G>T	ENST00000261722.3	-	15	1943	c.1736C>A	c.(1735-1737)gCg>gAg	p.A579E	AP3B2_ENST00000535348.1_Missense_Mutation_p.A547E|AP3B2_ENST00000535359.1_Missense_Mutation_p.A579E|RP11-752G15.3_ENST00000560650.1_RNA	NM_004644.3	NP_004635.2	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2 subunit	579					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			breast(4)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(2)	41			BRCA - Breast invasive adenocarcinoma(143;0.229)			GGTGAAGCGCGCCCGGTCGCG	0.597000													4	49					0.00909568	0.00967413	1	1	0
PLEKHM1	9842	broad.mit.edu	37	17	43552640	43552640	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr17:43552640G>A	ENST00000430334.3	-	4	882	c.749C>T	c.(748-750)tCc>tTc	p.S250F	PLEKHM1_ENST00000421073.2_Missense_Mutation_p.S161F	NM_014798.2	NP_055613.1	Q9Y4G2	PKHM1_HUMAN	pleckstrin homology domain containing, family M (with RUN domain) member 1	250					intracellular signal transduction	cytoplasm	metal ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|large_intestine(1)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	26	Renal(3;0.0405)					GCTGAGGGAGGAGGCAGTCAG	0.522000													10	40					0	0	1	0	0
PWP1	11137	broad.mit.edu	37	12	108086623	108086623	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr12:108086623C>G	ENST00000412830.3	+	4	520	c.352C>G	c.(352-354)Ctt>Gtt	p.L118V	PWP1_ENST00000541166.1_Missense_Mutation_p.L56V	NM_007062.1	NP_008993.1	Q13610	PWP1_HUMAN	PWP1 homolog (S. cerevisiae)	118					transcription, DNA-dependent	nucleus				breast(3)|endometrium(4)|kidney(1)|large_intestine(8)|lung(6)|urinary_tract(1)	23						TCTCTTGGGTCTTACGGTCTA	0.323000													12	39					0	0	1	0	0
ASXL2	55252	broad.mit.edu	37	2	25972772	25972772	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr2:25972772C>T	ENST00000435504.4	-	12	1946	c.1653G>A	c.(1651-1653)atG>atA	p.M551I	ASXL2_ENST00000404843.1_Missense_Mutation_p.M291I|ASXL2_ENST00000336112.4_Missense_Mutation_p.M523I|ASXL2_ENST00000272341.4_Missense_Mutation_p.M291I			Q76L83	ASXL2_HUMAN	additional sex combs like 2 (Drosophila)	551					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(3)	33	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GAGGTTCTTTCATATTAGTCT	0.502000													35	108					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61833576	61833576	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr10:61833576C>T	ENST00000280772.2	-	37	7254	c.7063G>A	c.(7063-7065)Gaa>Aaa	p.E2355K	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000355288.2_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)						establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						ATTTCTTTTTCTGGATGCTTT	0.378000													32	99					0	0	1	0	0
MDGA2	161357	broad.mit.edu	37	14	47389275	47389275	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr14:47389275C>G	ENST00000426342.1	-	10	2030	c.1284G>C	c.(1282-1284)tgG>tgC	p.W428C	MDGA2_ENST00000439988.3_Missense_Mutation_p.W726C|MDGA2_ENST00000357362.3_Missense_Mutation_p.W428C|MDGA2_ENST00000399232.2_Missense_Mutation_p.W657C	NM_182830.3	NP_878250.2	Q7Z553	MDGA2_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 2	657	Ig-like 4.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				breast(3)|endometrium(4)|kidney(2)|large_intestine(14)|lung(41)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(5)	76						TCATCTGTGTCCACTGTAGAC	0.433000													12	46					0	0	1	0	0
CD27	939	broad.mit.edu	37	12	6560112	6560112	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr12:6560112C>G	ENST00000266557.3	+	5	819	c.590C>G	c.(589-591)tCt>tGt	p.S197C	CD27-AS1_ENST00000545339.1_RNA|CD27_ENST00000541233.1_3'UTR|CD27-AS1_ENST00000399492.2_RNA	NM_001242.4	NP_001233	P26842	CD27_HUMAN	CD27 molecule	197					anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway|immunoglobulin mediated immune response|induction of apoptosis|positive regulation of B cell differentiation|positive regulation of JNK cascade|release of cytoplasmic sequestered NF-kappaB	extracellular region|integral to plasma membrane	caspase inhibitor activity|protein binding|transmembrane receptor activity			kidney(1)|large_intestine(5)|lung(1)|urinary_tract(3)	10						GTGATCTTCTCTGGAATGTTC	0.527000													33	147					0	0	1	0	0
SUN1	23353	broad.mit.edu	37	7	894630	894630	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr7:894630G>C	ENST00000456758.2	+	17	1904	c.1904G>C	c.(1903-1905)aGa>aCa	p.R635T	SUN1_ENST00000405266.1_Missense_Mutation_p.R483T|SUN1_ENST00000452783.2_Missense_Mutation_p.R343T|SUN1_ENST00000401592.1_Missense_Mutation_p.R446T|SUN1_ENST00000425407.2_Missense_Mutation_p.R363T|SUN1_ENST00000389574.3_Missense_Mutation_p.R363T|SUN1_ENST00000413514.2_Missense_Mutation_p.R244T			O94901	SUN1_HUMAN	Sad1 and UNC84 domain containing 1	473					cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane	integral to membrane|nuclear inner membrane|SUN-KASH complex	protein binding			NS(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(17)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						GGAAAACTGAGAGAAAAATCT	0.328000													3	44					0	0	1	0	0
MIR513A2	574510	broad.mit.edu	37	X	146307350	146307350	+	RNA	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chrX:146307350C>A	ENST00000385249.1	-	0	120					NR_030232.1																						Tcagggacaccacatatgcag	0.478000													3	46					0.115264	0.117939	1	1	0
MAPK14	1432	broad.mit.edu	37	6	36043703	36043703	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:36043703G>C	ENST00000229795.3	+	7	1021	c.574G>C	c.(574-576)Gag>Cag	p.E192Q	MAPK14_ENST00000310795.4_Missense_Mutation_p.E192Q|MAPK14_ENST00000468133.1_Missense_Mutation_p.E115Q|MAPK14_ENST00000229794.4_Missense_Mutation_p.E192Q	NM_001315.2	NP_001306.1	Q16539	MK14_HUMAN	mitogen-activated protein kinase 14	192	Protein kinase.				activation of MAPK activity|cellular component movement|cellular response to ionizing radiation|chemotaxis|innate immune response|mRNA metabolic process|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of muscle cell differentiation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|signal transduction in response to DNA damage|stress-activated MAPK cascade|stress-induced premature senescence|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|MAP kinase kinase activity|protein binding			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|stomach(1)	16						CAGGGCTCCTGAGATCATGCT	0.468000													16	42					0	0	1	0	0
TMEM65	157378	broad.mit.edu	37	8	125339618	125339618	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr8:125339618C>G	ENST00000297632.6	-	3	928	c.394G>C	c.(394-396)Gat>Cat	p.D132H		NM_194291.2	NP_919267.2	Q6PI78	TMM65_HUMAN	transmembrane protein 65	132						integral to membrane				cervix(1)|endometrium(1)|large_intestine(2)|lung(1)|prostate(1)	6	Lung NSC(37;1.18e-11)|Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			ATTGCATTATCCAAAAAGCCA	0.279000													10	31					0	0	1	0	0
CHRNA7	1139	broad.mit.edu	37	15	32460263	32460263	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr15:32460263G>A	ENST00000306901.3	+	10	1210	c.1113G>A	c.(1111-1113)atG>atA	p.M371I	CHRNA7_ENST00000455693.2_Missense_Mutation_p.M190I|CHRNA7_ENST00000454250.3_Missense_Mutation_p.M400I	NM_000746.5	NP_000737.1	P36544	ACHA7_HUMAN	cholinergic receptor, nicotinic, alpha 7 (neuronal)	371					activation of MAPK activity|calcium ion transport|cellular calcium ion homeostasis|memory|negative regulation of tumor necrosis factor production|positive regulation of angiogenesis|positive regulation of cell proliferation|response to hypoxia|response to nicotine	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|beta-amyloid binding|chloride channel regulator activity|nicotinic acetylcholine-activated cation-selective channel activity|protein homodimerization activity|toxin binding			endometrium(3)|large_intestine(1)|lung(6)|ovary(2)	12		all_lung(180;6.35e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)	Nicotine(DB00184)|Varenicline(DB01273)	GTGTGGAGATGAGCGCCGTGG	0.716000													11	69					0	0	1	0	0
CHODL	140578	broad.mit.edu	37	21	19632604	19632604	+	Splice_Site	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr21:19632604G>A	ENST00000299295.2	+	4	1025		c.e4+1		CHODL_ENST00000400127.1_Splice_Site|CHODL_ENST00000338326.3_Splice_Site|CHODL_ENST00000400135.1_Splice_Site|CHODL_ENST00000400128.1_Splice_Site|CHODL_ENST00000543733.1_Splice_Site|CHODL_ENST00000400131.1_Splice_Site	NM_001204175.1|NM_024944.2	NP_001191104.1|NP_079220.2	Q9H9P2	CHODL_HUMAN	chondrolectin						muscle organ development	integral to membrane|perinuclear region of cytoplasm	sugar binding			kidney(1)|large_intestine(3)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	12		all_epithelial(11;0.21)		Epithelial(23;0.000191)|all cancers(11;0.000827)|LUSC - Lung squamous cell carcinoma(23;0.00646)|Lung(58;0.0129)|OV - Ovarian serous cystadenocarcinoma(11;0.017)|COAD - Colon adenocarcinoma(22;0.03)|Colorectal(24;0.0917)		ACTGAAGCAGGTAATTACTTC	0.403000													23	56					0	0	1	0	0
ABCA1	19	broad.mit.edu	37	9	107591392	107591392	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr9:107591392C>A	ENST00000374736.3	-	15	2314	c.1920G>T	c.(1918-1920)atG>atT	p.M640I	ABCA1_ENST00000494467.1_5'UTR	NM_005502.3	NP_005493.2	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 1	640					Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(31)|liver(1)|lung(40)|ovary(5)|pancreas(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	115				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TGAAGAGGGGCATTGACCGGC	0.567000													8	28					0.000157383	0.000176284	1	1	0
GPR98	84059	broad.mit.edu	37	5	89925318	89925318	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr5:89925318G>C	ENST00000405460.2	+	9	1897	c.1801G>C	c.(1801-1803)Gat>Cat	p.D601H		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	601					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity	p.D601N(1)		NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		aataagaaatgatgcattcct	0.333000													12	18					0	0	1	0	0
AFF1	4299	broad.mit.edu	37	4	88026829	88026829	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr4:88026829G>A	ENST00000307808.6	+	8	1732	c.1312G>A	c.(1312-1314)Gaa>Aaa	p.E438K	AFF1_ENST00000544085.1_Missense_Mutation_p.E76K|AFF1_ENST00000395146.4_Missense_Mutation_p.E445K	NM_005935.2	NP_005926.1	P51825	AFF1_HUMAN	AF4/FMR2 family, member 1	438						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)|large_intestine(2)	3		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		CAGTGACAGTGAACAAGTAAG	0.428000													5	61					0	0	1	0	0
ZNF696	79943	broad.mit.edu	37	8	144378545	144378545	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr8:144378545G>C	ENST00000330143.3	+	3	1109	c.700G>C	c.(700-702)Gag>Cag	p.E234Q		NM_030895.2	NP_112157.2	Q9H7X3	ZN696_HUMAN	zinc finger protein 696	234					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			lung(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	8	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)			CCACACCGGGGAGAGGCTGTA	0.721000													4	23					0	0	1	0	0
CREBBP	1387	broad.mit.edu	37	16	3777907	3777907	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr16:3777907C>A	ENST00000262367.5	-	31	7950	c.7141G>T	c.(7141-7143)Ggt>Tgt	p.G2381C	CREBBP_ENST00000382070.3_Missense_Mutation_p.G2343C	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	2381					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		TGGGGGGAACCAGTCTGGGGT	0.642000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						21	53					8.04996e-18	1.01673e-17	1	1	0
PAPLN	89932	broad.mit.edu	37	14	73718408	73718408	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr14:73718408G>T	ENST00000427855.1	+	9	809	c.707G>T	c.(706-708)gGg>gTg	p.G236V	PAPLN_ENST00000555445.1_Missense_Mutation_p.G236V|PAPLN_ENST00000381166.3_Missense_Mutation_p.G236V|PAPLN_ENST00000340738.5_Missense_Mutation_p.G209V|PAPLN_ENST00000554301.1_Missense_Mutation_p.G236V			O95428	PPN_HUMAN	papilin, proteoglycan-like sulfated glycoprotein	236						proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(3)|pancreas(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(3)	42				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.0468)		TACCTCAATGGGCACTGGACC	0.662000													4	107					0.00909568	0.00967413	1	1	0
OASL	8638	broad.mit.edu	37	12	121465522	121465522	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr12:121465522C>G	ENST00000257570.5	-	4	1026	c.756G>C	c.(754-756)gaG>gaC	p.E252D	OASL_ENST00000339275.5_Intron	NM_003733.3	NP_003724.1	Q15646	OASL_HUMAN	2'-5'-oligoadenylate synthetase-like	252					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoplasm|nucleolus	ATP binding|DNA binding|double-stranded RNA binding|thyroid hormone receptor binding|transferase activity			NS(1)|endometrium(3)|large_intestine(4)|lung(4)|skin(2)	14	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					ACATGAAATTCTCGTCTTCTT	0.483000													25	39					0	0	1	0	0
RANBP2	5903	broad.mit.edu	37	2	109365525	109365525	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr2:109365525G>C	ENST00000283195.6	+	9	1339	c.1213G>C	c.(1213-1215)Gat>Cat	p.D405H		NM_006267.4	NP_006258.3	P49792	RBP2_HUMAN	RAN binding protein 2	405					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(34)	NS(1)|biliary_tract(1)|breast(3)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(21)|large_intestine(19)|lung(51)|pancreas(1)|prostate(8)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	129						TGGTAGCGATGATATTGGAAA	0.383000													72	298					0	0	1	0	0
APP	351	broad.mit.edu	37	21	27284167	27284167	+	Missense_Mutation	SNP	C	C	G	rs140304729		TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr21:27284167C>G	ENST00000358918.3	-	14	1994	c.1795G>C	c.(1795-1797)Gaa>Caa	p.E599Q	APP_ENST00000439274.2_Missense_Mutation_p.E543Q|APP_ENST00000348990.5_Missense_Mutation_p.E524Q|APP_ENST00000346798.3_Missense_Mutation_p.E599Q|APP_ENST00000448388.2_Missense_Mutation_p.E489Q|APP_ENST00000354192.3_Missense_Mutation_p.E468Q|APP_ENST00000440126.3_Missense_Mutation_p.E575Q|APP_ENST00000359726.3_Missense_Mutation_p.E543Q|APP_ENST00000357903.3_Missense_Mutation_p.E580Q	NM_001204301.1|NM_001204302.1	NP_001191230.1|NP_001191231.1	P05067	A4_HUMAN	amyloid beta (A4) precursor protein	599					adult locomotory behavior|axon cargo transport|axon midline choice point recognition|cell adhesion|cellular copper ion homeostasis|collateral sprouting in absence of injury|dendrite development|endocytosis|extracellular matrix organization|G2 phase of mitotic cell cycle|innate immune response|ionotropic glutamate receptor signaling pathway|mating behavior|mRNA polyadenylation|neuron apoptosis|neuron remodeling|Notch signaling pathway|platelet activation|platelet degranulation|positive regulation of mitotic cell cycle|protein phosphorylation|regulation of epidermal growth factor receptor activity|regulation of multicellular organism growth|regulation of synapse structure and activity|regulation of translation|visual learning	axon|cell surface|coated pit|dendritic shaft|dendritic spine|extracellular region|Golgi apparatus|integral to plasma membrane|platelet alpha granule lumen	acetylcholine receptor binding|DNA binding|heparin binding|identical protein binding|metal ion binding|protein binding|PTB domain binding|serine-type endopeptidase inhibitor activity			endometrium(5)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	22		Breast(209;0.00295)				GTTTTCGTTTCGGTCAAAGAT	0.502000													25	103					0	0	1	0	0
AP2A1	160	broad.mit.edu	37	19	50305837	50305837	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr19:50305837G>A	ENST00000359032.5	+	16	2161	c.2161G>A	c.(2161-2163)Gac>Aac	p.D721N	AP2A1_ENST00000354293.5_Intron	NM_014203.2	NP_055018.2	O95782	AP2A1_HUMAN	adaptor-related protein complex 2, alpha 1 subunit	721					axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|Golgi to endosome transport|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|clathrin coat of trans-Golgi network vesicle|cytosol	protein binding|protein transporter activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)	19		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.0023)|GBM - Glioblastoma multiforme(134;0.0157)		TTTGCTGGCTGACCCAGCTCC	0.682000													3	8					0	0	1	0	0
IVNS1ABP	10625	broad.mit.edu	37	1	185270194	185270194	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr1:185270194C>G	ENST00000367498.3	-	10	1652	c.1030G>C	c.(1030-1032)Gat>Cat	p.D344H	IVNS1ABP_ENST00000459929.1_5'UTR|IVNS1ABP_ENST00000392007.3_Missense_Mutation_p.D126H	NM_006469.4	NP_006460.2	Q9Y6Y0	NS1BP_HUMAN	influenza virus NS1A binding protein	344	Sufficient for AHR interaction and signaling.				interspecies interaction between organisms|response to virus|RNA splicing|transcription from RNA polymerase III promoter	cytoplasm|cytoskeleton|spliceosomal complex|transcription factor complex				breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|ovary(4)|prostate(2)	29						ATTAGCTCATCTTGTTGCATC	0.433000													18	46					0	0	1	0	0
DNMT1	1786	broad.mit.edu	37	19	10291220	10291220	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr19:10291220G>C	ENST00000340748.4	-	4	486	c.251C>G	c.(250-252)tCc>tGc	p.S84C	DNMT1_ENST00000540357.1_Missense_Mutation_p.S84C|DNMT1_ENST00000359526.4_Missense_Mutation_p.S84C			P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1	84	Interaction with DMAP1.|Interaction with DNMT3A.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			breast(5)|endometrium(8)|kidney(5)|large_intestine(21)|lung(11)|ovary(2)|pancreas(1)|prostate(10)|skin(5)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	ATTTAAAAGGGATTTGACTTT	0.428000													27	63					0	0	1	0	0
CYFIP2	26999	broad.mit.edu	37	5	156721804	156721804	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr5:156721804G>T	ENST00000347377.6	+	4	651	c.220G>T	c.(220-222)Gag>Tag	p.E74*	CYFIP2_ENST00000521420.1_Intron|CYFIP2_ENST00000442283.2_5'UTR|CYFIP2_ENST00000522463.1_Intron|CYFIP2_ENST00000541131.1_Intron|CYFIP2_ENST00000377576.3_Nonsense_Mutation_p.E74*|CYFIP2_ENST00000318218.6_Nonsense_Mutation_p.E74*	NM_001037332.2	NP_001032409.2	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	74					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding			breast(1)|endometrium(12)|kidney(2)|lung(23)	38	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TGAGATGCTGGAGGAAGGACA	0.542000													4	25					0.000602214	0.000665317	1	1	0
PRL	5617	broad.mit.edu	37	6	22287784	22287784	+	Silent	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:22287784G>C	ENST00000306482.1	-	5	1049	c.531C>G	c.(529-531)gtC>gtG	p.V177V	RP3-404K8.2_ENST00000561912.1_RNA	NM_000948.5|NM_001163558.2	NP_000939.1|NP_001157030.1	P01236	PRL_HUMAN	prolactin	177					cell proliferation|cell surface receptor linked signaling pathway|female pregnancy|lactation|positive regulation of JAK-STAT cascade|regulation of multicellular organism growth	cytosol|extracellular region	hormone activity|prolactin receptor binding			NS(1)|endometrium(2)|large_intestine(6)|lung(6)|prostate(1)	16	Ovarian(93;0.163)					GTCCCGACCAGACAGGGTAGA	0.413000													9	39					0	0	1	0	0
PDXDC2P	283970	broad.mit.edu	37	16	70010650	70010650	+	RNA	SNP	A	A	G	rs144900726	by1000genomes	TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr16:70010650A>G	ENST00000531894.1	-	0	3748					NR_003610.1																						AGGGCCGAAGAAGGGAATGTT	0.468000													5	83					0	0	1	0	0
SNCAIP	9627	broad.mit.edu	37	5	121780284	121780284	+	Silent	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr5:121780284C>T	ENST00000261367.7	+	10	3018	c.1590C>T	c.(1588-1590)gtC>gtT	p.V530V	SNCAIP_ENST00000542191.1_Silent_p.V41V|SNCAIP_ENST00000379538.3_Silent_p.V117V|SNCAIP_ENST00000379536.2_Silent_p.V423V|CTC-210G5.1_ENST00000509993.1_RNA|CTC-210G5.1_ENST00000506053.1_RNA|SNCAIP_ENST00000261368.8_Silent_p.V483V|CTC-210G5.1_ENST00000510972.1_RNA|CTC-210G5.1_ENST00000503529.1_RNA|SNCAIP_ENST00000414317.2_Silent_p.V85V|SNCAIP_ENST00000379533.2_Silent_p.V530V|SNCAIP_ENST00000504884.2_3'UTR|SNCAIP_ENST00000503116.2_3'UTR			Q9Y6H5	SNCAP_HUMAN	synuclein, alpha interacting protein	483					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			NS(3)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	39		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		GAGCAAATGTCACCATGCAGA	0.502000													7	72					0	0	1	0	0
NEK1	4750	broad.mit.edu	37	4	170327844	170327844	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr4:170327844C>A	ENST00000439128.2	-	30	3833	c.3193G>T	c.(3193-3195)Gat>Tat	p.D1065Y	NEK1_ENST00000510533.1_Missense_Mutation_p.D1021Y|NEK1_ENST00000507142.1_Missense_Mutation_p.D1093Y|NEK1_ENST00000512193.1_Missense_Mutation_p.D996Y|NEK1_ENST00000511633.1_Missense_Mutation_p.D1049Y	NM_012224.2	NP_036356.1	Q96PY6	NEK1_HUMAN	NIMA-related kinase 1	1065					cell division|cilium assembly|mitosis	nucleus|pericentriolar material	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|stomach(1)	45		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)|KIRC - Kidney renal clear cell carcinoma(143;0.0325)|Kidney(143;0.0385)|LUSC - Lung squamous cell carcinoma(193;0.14)		GTGGGAACATCCATAAGGGTT	0.333000													3	33					1	1	1	1	0
ZNF793	390927	broad.mit.edu	37	19	38027962	38027962	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr19:38027962G>C	ENST00000445217.1	+	4	437	c.402G>C	c.(400-402)caG>caC	p.Q134H	ZNF793_ENST00000589319.1_Missense_Mutation_p.Q134H|ZNF793_ENST00000588578.1_3'UTR|ZNF793_ENST00000542455.1_Missense_Mutation_p.Q134H|ZNF793_ENST00000587143.1_Missense_Mutation_p.Q134H			Q6ZN11	ZN793_HUMAN	zinc finger protein 793	134					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(2)|lung(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CTTCAATCCAGAGCCCTAGTA	0.363000													10	25					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22191810	22191810	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr1:22191810C>T	ENST00000374695.3	-	35	4442	c.4363G>A	c.(4363-4365)Gag>Aag	p.E1455K		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	1455	Laminin IV type A 3.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CTCCTCCTCTCAGGGCCCTGC	0.627000													10	59					0	0	1	0	0
SEMA3C	10512	broad.mit.edu	37	7	80439972	80439972	+	Missense_Mutation	SNP	G	G	A	rs146671063	by1000genomes	TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr7:80439972G>A	ENST00000265361.3	-	6	1054	c.493C>T	c.(493-495)Cgc>Tgc	p.R165C	SEMA3C_ENST00000419255.2_Missense_Mutation_p.R165C|SEMA3C_ENST00000536800.1_Missense_Mutation_p.R17C|SEMA3C_ENST00000544525.1_Missense_Mutation_p.R183C	NM_006379.3	NP_006370.1	Q99985	SEM3C_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	165	Sema.				immune response|response to drug	membrane	receptor activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						AAAGAGCAGCGTCCTTTTCCA	0.358000													32	59					0	0	1	0	0
NUDT19	390916	broad.mit.edu	37	19	33183437	33183437	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr19:33183437A>G	ENST00000397061.3	+	1	571	c.571A>G	c.(571-573)Atc>Gtc	p.I191V		NM_001105570.1	NP_001099040.1	A8MXV4	NUD19_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 19	191	Nudix hydrolase.					mitochondrion|peroxisome	hydrolase activity|metal ion binding			endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	8	Esophageal squamous(110;0.137)					CACACCCGACATCTGGGCGCT	0.716000													11	15					0	0	1	0	0
JMJD6	23210	broad.mit.edu	37	17	74714847	74714847	+	Missense_Mutation	SNP	G	G	A	rs149210415	by1000genomes	TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr17:74714847G>A	ENST00000585429.1	-	5	1064	c.1037C>T	c.(1036-1038)aCg>aTg	p.T346M	JMJD6_ENST00000397625.4_Silent_p.D392D|JMJD6_ENST00000445478.2_Silent_p.D392D			Q6NYC1	JMJD6_HUMAN	jumonji domain containing 6	0	Ser-rich.				mRNA processing|peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine|regulation of nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|RNA splicing|sprouting angiogenesis|transcription, DNA-dependent	nucleolus|nucleoplasm	histone demethylase activity (H3-R2 specific)|histone demethylase activity (H4-R3 specific)|identical protein binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptidyl-lysine 5-dioxygenase activity|single-stranded RNA binding			endometrium(2)|kidney(5)|large_intestine(2)|lung(3)|ovary(2)|skin(2)	16						TGACACAGTCGTCCTGGGAGG	0.632000													14	39					0	0	1	0	0
ZNF276	92822	broad.mit.edu	37	16	89799951	89799951	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr16:89799951G>T	ENST00000289816.5	+	8	1429	c.1117G>T	c.(1117-1119)Gct>Tct	p.A373S	ZNF276_ENST00000446326.2_Missense_Mutation_p.A234S|ZNF276_ENST00000443381.2_Missense_Mutation_p.A448S|ZNF276_ENST00000568064.1_Missense_Mutation_p.A356S	NM_152287.3	NP_689500.2	Q8N554	ZN276_HUMAN	zinc finger protein 276	448					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(6)|prostate(1)	14		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		GTACCGAGGCGCTGACGGCAT	0.622000													5	83					0.00116845	0.00127062	1	1	0
APBA2	321	broad.mit.edu	37	15	29346705	29346705	+	Silent	SNP	C	C	T	rs111870710	byFrequency	TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr15:29346705C>T	ENST00000558402.1	+	5	1217	c.618C>T	c.(616-618)ggC>ggT	p.G206G	APBA2_ENST00000561069.1_Silent_p.G206G|APBA2_ENST00000411764.1_Silent_p.G206G|APBA2_ENST00000558259.1_Silent_p.G206G|APBA2_ENST00000558330.1_Silent_p.G206G			Q99767	APBA2_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 2	206	STXBP1-binding.			DEPSVLEAHDQEEDGHYCASKEGYQDYYPEEANGNTGASPY RLRR -> MSPPSLRPMTRKKMVTMCQQRGLPGLLPRGGQR EHRRLPLPPEA (in Ref. 1; AAC39767).	nervous system development|protein transport		protein binding	p.G206G(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|liver(2)|lung(33)|stomach(1)|urinary_tract(1)	59		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		GGAACACCGGCGCCTCCCCCT	0.607000													5	11					0	0	1	0	0
ATP6V1B2	526	broad.mit.edu	37	8	20069162	20069162	+	Splice_Site	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr8:20069162G>A	ENST00000276390.2	+	7	643		c.e7-1			NM_001693.3	NP_001684.2	P21281	VATB2_HUMAN	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2						ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|endomembrane system|Golgi apparatus|melanosome|plasma membrane|proton-transporting V-type ATPase, V1 domain	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			endometrium(1)|kidney(2)|lung(5)|prostate(1)	9				Colorectal(74;0.0535)|COAD - Colon adenocarcinoma(73;0.211)		TTGTTCATCAGATTGCAGCTC	0.333000													3	11					0	0	1	0	0
RAB6C-AS1	100131320	broad.mit.edu	37	2	130725932	130725932	+	RNA	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr2:130725932C>T	ENST00000412425.1	-	0	686					NR_036537.1																						TGAGCCTGACCACTTGTGTTG	0.393000													9	45					0	0	1	0	0
P2RX2	22953	broad.mit.edu	37	12	133196895	133196895	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr12:133196895C>G	ENST00000389110.3	+	6	634	c.597C>G	c.(595-597)atC>atG	p.I199M	P2RX2_ENST00000449132.2_Missense_Mutation_p.Q164E|P2RX2_ENST00000352418.4_Missense_Mutation_p.I127M|P2RX2_ENST00000350048.5_Missense_Mutation_p.I175M|P2RX2_ENST00000348800.5_Missense_Mutation_p.I199M|P2RX2_ENST00000351222.4_Missense_Mutation_p.I107M|P2RX2_ENST00000343948.4_Missense_Mutation_p.I199M	NM_170682.2|NM_170683.2|NM_174873.1	NP_733782.1|NP_733783.1|NP_777362.1	Q9UBL9	P2RX2_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 2	199					positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling|protein homooligomerization	integral to membrane	ATP binding|extracellular ATP-gated cation channel activity|identical protein binding|purinergic nucleotide receptor activity			NS(1)|breast(1)|kidney(2)|large_intestine(2)|liver(2)|lung(8)|ovary(1)|prostate(3)	20	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0767)		OV - Ovarian serous cystadenocarcinoma(86;2.32e-08)|Epithelial(86;8.62e-08)|all cancers(50;4.5e-06)		CCATCCTCATCAAGAACAGCA	0.567000													6	47					0	0	1	0	0
SYPL1	6856	broad.mit.edu	37	7	105732365	105732365	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr7:105732365C>G	ENST00000455385.2	-	5	734	c.612G>C	c.(610-612)atG>atC	p.M204I	SYPL1_ENST00000011473.2_Missense_Mutation_p.M222I|SYPL1_ENST00000470347.1_3'UTR	NM_182715.2	NP_874384.1	Q16563	SYPL1_HUMAN	synaptophysin-like 1	222	MARVEL.				synaptic transmission	cytoplasmic vesicle membrane|integral to plasma membrane|melanosome|synaptic vesicle	transporter activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|prostate(1)	7						CCCAGAGTATCATATTTAGAA	0.368000													13	31					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114278501	114278501	+	Silent	SNP	C	C	A	rs144821187	byFrequency	TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr4:114278501C>A	ENST00000357077.4	+	38	8780	c.8727C>A	c.(8725-8727)ccC>ccA	p.P2909P	ANK2_ENST00000394537.3_Intron|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000509550.1_Intron|ANK2_ENST00000264366.6_Silent_p.P2876P|ANK2_ENST00000510275.2_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2876					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding	p.P2909P(1)		NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TGGATGTTCCCGTGTCTGACC	0.393000													6	148					0.00116845	0.00127062	1	1	0
SPIRE1	56907	broad.mit.edu	37	18	12512522	12512522	+	Silent	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr18:12512522C>T	ENST00000409402.4	-	5	1005	c.738G>A	c.(736-738)aaG>aaA	p.K246K	SPIRE1_ENST00000453447.2_Silent_p.K126K|SPIRE1_ENST00000309836.5_Silent_p.K49K|SPIRE1_ENST00000410092.3_Silent_p.K246K|SPIRE1_ENST00000383356.2_Silent_p.K87K	NM_001128626.1	NP_001122098.1	Q08AE8	SPIR1_HUMAN	spire-type actin nucleation factor 1	246						cytoskeleton|perinuclear region of cytoplasm	actin binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)	28						CTTGAATCTTCTTAAGATTCT	0.328000													12	41					0	0	1	0	0
AP2A2	161	broad.mit.edu	37	11	985542	985542	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr11:985542G>A	ENST00000448903.2	+	8	1063	c.922G>A	c.(922-924)Gtg>Atg	p.V308M	AP2A2_ENST00000332231.5_Missense_Mutation_p.V309M|AP2A2_ENST00000534328.1_Missense_Mutation_p.V308M	NM_001242837.1|NM_012305.3	NP_001229766.1|NP_036437.1	O94973	AP2A2_HUMAN	adaptor-related protein complex 2, alpha 2 subunit	308					axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|cytosol	lipid binding|protein transporter activity			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|ovary(2)	21		all_cancers(49;9.46e-06)|Breast(177;0.00257)|all_epithelial(84;0.0027)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.75e-24)|BRCA - Breast invasive adenocarcinoma(625;5.73e-05)|Lung(200;0.0696)|LUSC - Lung squamous cell carcinoma(625;0.082)		GAAGAATGCCGTGCTCTTCGA	0.572000													4	33					0	0	1	0	0
C9orf156	51531	broad.mit.edu	37	9	100667174	100667174	+	Silent	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr9:100667174C>A	ENST00000375119.3	-	5	1243	c.1167G>T	c.(1165-1167)cgG>cgT	p.R389R		NM_016481.3	NP_057565.3	Q9BU70	NAP1_HUMAN	chromosome 9 open reading frame 156	389					interspecies interaction between organisms		hydrolase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(3)|prostate(1)|skin(1)	13		Acute lymphoblastic leukemia(62;0.158)				GGCAAAGCTTCCGGCGGTACA	0.517000													17	34					2.35188e-11	2.89508e-11	1	1	0
ENKD1	84080	broad.mit.edu	37	16	67697120	67697120	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr16:67697120C>G	ENST00000243878.4	-	7	1306	c.985G>C	c.(985-987)Gag>Cag	p.E329Q	ENKD1_ENST00000602644.1_3'UTR	NM_032140.1	NP_115516.1			enkurin domain containing 1																		ATGGCCTCCTCTACCTGCACC	0.607000													12	63					0	0	1	0	0
PLXNB2	23654	broad.mit.edu	37	22	50716359	50716359	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr22:50716359G>C	ENST00000449103.1	-	32	5111	c.4971C>G	c.(4969-4971)ttC>ttG	p.F1657L	PLXNB2_ENST00000359337.4_Missense_Mutation_p.F1657L			O15031	PLXB2_HUMAN	plexin B2	1657					regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			breast(2)|central_nervous_system(4)|cervix(2)|endometrium(11)|kidney(4)|large_intestine(3)|liver(1)|lung(20)|ovary(5)|prostate(6)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	66		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GGAAGTCGAAGAAGTACTTGA	0.602000													4	48					0	0	1	0	0
TAF4	6874	broad.mit.edu	37	20	60578917	60578917	+	Silent	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr20:60578917C>T	ENST00000252996.4	-	8	2240	c.2241G>A	c.(2239-2241)ccG>ccA	p.P747P		NM_003185.3	NP_003176.2	O00268	TAF4_HUMAN	TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa						interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	37	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			CTCCTGGCTTCGGAGGCTGCT	0.652000													10	16					0	0	1	0	0
PHACTR2	9749	broad.mit.edu	37	6	144033176	144033176	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:144033176A>G	ENST00000427704.2	+	2	167	c.37A>G	c.(37-39)Ata>Gta	p.I13V	PHACTR2_ENST00000367584.4_Missense_Mutation_p.I81V|PHACTR2_ENST00000367582.3_Missense_Mutation_p.I24V|PHACTR2_ENST00000305766.6_Missense_Mutation_p.I13V|PHACTR2_ENST00000440869.2_Missense_Mutation_p.I24V|PHACTR2_ENST00000397980.3_Missense_Mutation_p.I24V	NM_001100166.1|NM_014721.2	NP_001093636.1|NP_055536.2	O75167	PHAR2_HUMAN	phosphatase and actin regulator 2	13							actin binding|protein phosphatase inhibitor activity			NS(3)|breast(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	30				OV - Ovarian serous cystadenocarcinoma(155;1.58e-05)|GBM - Glioblastoma multiforme(68;0.0386)		CAAAGCTTCTATAGCAAACTC	0.408000													70	83					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	145010082	145010082	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr8:145010082C>T	ENST00000322810.4	-	6	1116	c.947G>A	c.(946-948)cGa>cAa	p.R316Q	PLEC_ENST00000354589.3_Missense_Mutation_p.R179Q|PLEC_ENST00000356346.3_Missense_Mutation_p.R165Q|PLEC_ENST00000436759.2_Missense_Mutation_p.R206Q|PLEC_ENST00000354958.2_Missense_Mutation_p.R157Q|PLEC_ENST00000357649.2_Missense_Mutation_p.R183Q|PLEC_ENST00000398774.2_Missense_Mutation_p.R147Q|PLEC_ENST00000527096.1_Missense_Mutation_p.R206Q|PLEC_ENST00000345136.3_Missense_Mutation_p.R179Q	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	316	Actin-binding.|CH 2.|Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						GTTGTCGCATCGCAGGCCCTG	0.627000													4	54					0	0	1	0	0
MET	4233	broad.mit.edu	37	7	116436174	116436174	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr7:116436174C>G	ENST00000397752.3	+	21	4369	c.4169C>G	c.(4168-4170)tCa>tGa	p.S1390*	MET_ENST00000318493.6_Nonsense_Mutation_p.S1408*|MET_ENST00000539704.1_Nonsense_Mutation_p.S260*	NM_000245.2|NM_001127500.1	NP_000236.2|NP_001120972.1	P08581	MET_HUMAN	met proto-oncogene	1390	Interaction with RANBP9.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			NS(10)|breast(4)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(25)|large_intestine(8)|liver(3)|lung(70)|ovary(10)|pleura(2)|prostate(4)|skin(5)|stomach(6)|testis(1)|thyroid(4)|upper_aerodigestive_tract(64)|urinary_tract(3)	233	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			TGGGAGACATCATAGTGCTAG	0.453000			Mis		"""papillary renal, head-neck squamous cell """	papillary renal			Hereditary Papillary Renal Carcinoma (type 1)				38	85					0	0	1	0	0
AP4E1	23431	broad.mit.edu	37	15	51242073	51242073	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr15:51242073C>T	ENST00000261842.5	+	12	1473	c.1367C>T	c.(1366-1368)tCa>tTa	p.S456L	AP4E1_ENST00000560508.1_Missense_Mutation_p.S381L	NM_001252127.1|NM_007347.4	NP_001239056.1|NP_031373.2	Q9UPM8	AP4E1_HUMAN	adaptor-related protein complex 4, epsilon 1 subunit	456					intracellular protein transport|vesicle-mediated transport	COPI vesicle coat	binding|structural molecule activity			breast(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(5)|skin(2)	27				all cancers(107;0.000893)|GBM - Glioblastoma multiforme(94;0.00364)		GCTGTGTTTTCAGTAGGAGGA	0.348000													19	48					0	0	1	0	0
PDLIM2	64236	broad.mit.edu	37	8	22438123	22438123	+	Silent	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr8:22438123G>A	ENST00000265810.4	+	1	121	c.6G>A	c.(4-6)gcG>gcA	p.A2A	PDLIM2_ENST00000308354.7_Silent_p.A252A|PDLIM2_ENST00000397760.4_Silent_p.A2A|PDLIM2_ENST00000409141.1_Silent_p.A2A|PDLIM2_ENST00000409417.1_Silent_p.A2A|PDLIM2_ENST00000339162.7_Silent_p.A2A|PDLIM2_ENST00000397761.2_Silent_p.A2A	NM_176871.3	NP_789847.1	Q96JY6	PDLI2_HUMAN	PDZ and LIM domain 2 (mystique)	2	PDZ.					actin cytoskeleton|cell surface|cytoplasm|focal adhesion|nucleus	zinc ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|urinary_tract(1)	9		Prostate(55;0.0421)|Breast(100;0.102)|all_epithelial(46;0.142)		BRCA - Breast invasive adenocarcinoma(99;0.00579)|Colorectal(74;0.0152)|COAD - Colon adenocarcinoma(73;0.0626)		CAGGTATGGCGTTGACGGTGG	0.617000													6	24					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13901432	13901432	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr5:13901432G>A	ENST00000265104.4	-	14	2085	c.1981C>T	c.(1981-1983)Cgc>Tgc	p.R661C		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	661	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity	p.R661C(1)		NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TTGTAACTGCGAATTATAGGT	0.532000									Kartagener syndrome				10	38					0	0	1	0	0
PRRC2A	7916	broad.mit.edu	37	6	31604530	31604530	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:31604530C>G	ENST00000376033.2	+	28	6189	c.5955C>G	c.(5953-5955)gaC>gaG	p.D1985E	PRRC2A_ENST00000376007.4_Missense_Mutation_p.D1985E	NM_004638.3	NP_004629.3	P48634	PRC2A_HUMAN	proline-rich coiled-coil 2A	1985	3 X 50 AA type C repeats.					cytoplasm|nucleus	protein binding			breast(6)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|lung(19)|ovary(3)|pancreas(2)|prostate(4)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	70						CCATGGTAGACTCACAGCTGC	0.562000													96	123					0	0	1	0	0
ICK	22858	broad.mit.edu	37	6	52906030	52906030	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:52906030T>C	ENST00000356971.3	-	3	494	c.5A>G	c.(4-6)aAt>aGt	p.N2S	ICK_ENST00000350082.5_Missense_Mutation_p.N2S	NM_016513.4	NP_057597.2	Q9UPZ9	ICK_HUMAN	intestinal cell (MAK-like) kinase	2					intracellular protein kinase cascade|multicellular organismal development	cytosol|nucleus	ATP binding|cyclin-dependent protein kinase activity|magnesium ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(3)|stomach(1)	31	Lung NSC(77;0.103)					TGTGTATCTATTCATGGTGTG	0.517000													13	62					0	0	1	0	0
ASB2	51676	broad.mit.edu	37	14	94419818	94419818	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr14:94419818C>G	ENST00000555019.1	-	5	944	c.514G>C	c.(514-516)Gag>Cag	p.E172Q	ASB2_ENST00000556337.1_Intron|ASB2_ENST00000315988.4_Missense_Mutation_p.E124Q	NM_001202429.1	NP_001189358.1	Q96Q27	ASB2_HUMAN	ankyrin repeat and SOCS box containing 2	124					intracellular signal transduction					breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(8)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|soft_tissue(1)|urinary_tract(1)	27		all_cancers(154;0.13)		COAD - Colon adenocarcinoma(157;0.217)|Epithelial(152;0.232)		GCTGTTTCCTCCTGCAGGGTG	0.597000													6	23					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51174227	51174227	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr16:51174227T>C	ENST00000440970.1	-	2	2046	c.1615A>G	c.(1615-1617)Acg>Gcg	p.T539A	SALL1_ENST00000251020.4_Missense_Mutation_p.T636A|SALL1_ENST00000566102.1_Intron|SALL1_ENST00000541611.1_Intron	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	636					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			CTGCTCGCCGTCGGGACTGAG	0.632000													5	37					0	0	1	0	0
KNDC1	85442	broad.mit.edu	37	10	135012623	135012623	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr10:135012623G>A	ENST00000304613.3	+	14	2632	c.2611G>A	c.(2611-2613)Gac>Aac	p.D871N	KNDC1_ENST00000368571.2_Missense_Mutation_p.D806N|KNDC1_ENST00000368572.2_Missense_Mutation_p.D871N			Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND) containing 1	871	Pro-rich.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction			p.D871N(1)		NS(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(27)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	60		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		GCGGCCCGCAGACCGGAGGCT	0.721000													3	6					0	0	1	0	0
NUDT5	11164	broad.mit.edu	37	10	12215717	12215717	+	Splice_Site	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr10:12215717C>T	ENST00000491614.1	-	6	780	c.385G>A	c.(385-387)Gcg>Acg	p.A129T	NUDT5_ENST00000378940.3_Splice_Site_p.A129T|NUDT5_ENST00000537776.1_Splice_Site_p.A129T|NUDT5_ENST00000378927.3_Splice_Site_p.A129T|NUDT5_ENST00000378952.3_5'UTR|NUDT5_ENST00000378937.3_Splice_Site_p.A142T			Q9UKK9	NUDT5_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 5	129	Nudix hydrolase.				D-ribose catabolic process|ribonucleoside diphosphate catabolic process	intracellular	ADP-ribose diphosphatase activity|magnesium ion binding			breast(1)|large_intestine(1)|lung(4)|ovary(1)|pancreas(1)	8		Renal(717;0.228)				CAATACCAACCTGGAGAACAT	0.463000													37	123					0	0	1	0	0
CDC42BPB	9578	broad.mit.edu	37	14	103410592	103410592	+	Silent	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr14:103410592C>A	ENST00000361246.2	-	30	4332	c.4044G>T	c.(4042-4044)gtG>gtT	p.V1348V		NM_006035.3	NP_006026.3	Q9Y5S2	MRCKB_HUMAN	CDC42 binding protein kinase beta (DMPK-like)	1348	CNH.				actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity	p.V1348V(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(11)|liver(1)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	49		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		TCAGCCGTTTCACGGCCACAA	0.557000													9	55					2.17888e-05	2.50416e-05	1	1	0
MIR513A2	574510	broad.mit.edu	37	X	146307349	146307349	+	RNA	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chrX:146307349C>A	ENST00000385249.1	-	0	121					NR_030232.1																						CTcagggacaccacatatgca	0.473000													3	47					0.00909568	0.00967413	1	1	0
ZNF852	285346	broad.mit.edu	37	3	44540951	44540951	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr3:44540951C>G	ENST00000436261.1	-	4	1478	c.1318G>C	c.(1318-1320)Gaa>Caa	p.E440Q				B6EU87	B6EU87_HUMAN	zinc finger protein 852	440					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			endometrium(2)|kidney(1)|lung(5)	8						TCATTACATTCATAGGGTTTC	0.378000													4	41					0	0	1	0	0
IGHV1-8	28472	broad.mit.edu	37	14	106539261	106539261	+	RNA	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr14:106539261G>T	ENST00000390599.2	-	0	230																											GTGGCCTGTCGCACCCAGTTG	0.547000													11	87					0.0692343	0.0711412	1	1	0
PUS7	54517	broad.mit.edu	37	7	105148620	105148620	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr7:105148620C>T	ENST00000356362.2	-	2	554	c.340G>A	c.(340-342)Gta>Ata	p.V114I	PUS7_ENST00000469408.1_Missense_Mutation_p.V114I	NM_019042.3	NP_061915.2	Q96PZ0	PUS7_HUMAN	pseudouridylate synthase 7 homolog (S. cerevisiae)	114					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(8)|pancreas(1)|skin(1)	23						GTGATGCCTACGTCAGCCTCA	0.418000													24	60					0	0	1	0	0
GABRA2	2555	broad.mit.edu	37	4	46307650	46307650	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr4:46307650G>C	ENST00000510861.1	-	7	811	c.638C>G	c.(637-639)tCt>tGt	p.S213C	GABRA2_ENST00000514090.1_Missense_Mutation_p.S213C|GABRA2_ENST00000540012.1_Missense_Mutation_p.S158C|GABRA2_ENST00000507069.1_Missense_Mutation_p.S213C|GABRA2_ENST00000515082.1_Missense_Mutation_p.S213C|GABRA2_ENST00000381620.4_Missense_Mutation_p.S213C|GABRA2_ENST00000356504.1_Missense_Mutation_p.S213C			P47869	GBRA2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 2	213					gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	56					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	ATTTAACCTAGAGCCATCAGG	0.368000													21	87					0	0	1	0	0
AGAP10	728127	broad.mit.edu	37	10	47207813	47207813	+	Splice_Site	SNP	T	T	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr10:47207813T>C	ENST00000355232.3	-	5	3482	c.470A>G	c.(469-471)cAt>cGt	p.H157R	AGAP10_ENST00000452145.2_Splice_Site_p.H132R|RP11-144G6.12_ENST00000605970.1_RNA|AGAP10_ENST00000413193.2_Splice_Site_p.H228R					ArfGAP with GTPase domain, ankyrin repeat and PH domain 10									p.H228R(20)		endometrium(5)|kidney(3)|lung(1)|prostate(2)|urinary_tract(1)	12						TTTACTTACATGGTTTGTACA	0.294000													3	58					0	0	1	0	0
CHKA	1119	broad.mit.edu	37	11	67838308	67838308	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr11:67838308G>A	ENST00000265689.4	-	5	673	c.647C>T	c.(646-648)aCt>aTt	p.T216I	CHKA_ENST00000356135.5_Missense_Mutation_p.T198I	NM_001277.2	NP_001268.2	P35790	CHKA_HUMAN	choline kinase alpha	216					lipid transport|phosphatidylethanolamine biosynthetic process	cytoplasm	ATP binding|choline kinase activity|drug binding|ethanolamine kinase activity|signal transducer activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(5)|ovary(1)|skin(1)	13					Choline(DB00122)	TAATTCTTCAGTATCTAATCG	0.368000													53	67					0	0	1	0	0
NXPH4	11247	broad.mit.edu	37	12	57619092	57619092	+	Silent	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr12:57619092C>T	ENST00000349394.5	+	2	664	c.489C>T	c.(487-489)ttC>ttT	p.F163F	NXPH4_ENST00000555154.1_3'UTR	NM_007224.3	NP_009155.1	O95158	NXPH4_HUMAN	neurexophilin 4	163	III.				neuropeptide signaling pathway	extracellular region				NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|lung(2)|stomach(1)|upper_aerodigestive_tract(1)	10						GTGTCGAGTTCGGAGGAGTCT	0.657000													4	131					0	0	1	0	0
CYFIP2	26999	broad.mit.edu	37	5	156721803	156721803	+	Silent	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr5:156721803G>T	ENST00000347377.6	+	4	650	c.219G>T	c.(217-219)ctG>ctT	p.L73L	CYFIP2_ENST00000521420.1_Intron|CYFIP2_ENST00000442283.2_5'UTR|CYFIP2_ENST00000522463.1_Intron|CYFIP2_ENST00000541131.1_Intron|CYFIP2_ENST00000377576.3_Silent_p.L73L|CYFIP2_ENST00000318218.6_Silent_p.L73L	NM_001037332.2	NP_001032409.2	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	73					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding			breast(1)|endometrium(12)|kidney(2)|lung(23)	38	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			ATGAGATGCTGGAGGAAGGAC	0.542000													4	25					0.000602214	0.000665317	1	1	0
PCDHA1	56147	broad.mit.edu	37	5	140166206	140166206	+	Missense_Mutation	SNP	G	G	A	rs148838866		TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr5:140166206G>A	ENST00000504120.2	+	1	331	c.331G>A	c.(331-333)Gac>Aac	p.D111N	PCDHA1_ENST00000394633.3_Missense_Mutation_p.D111N|PCDHA1_ENST00000378133.3_Missense_Mutation_p.D111N	NM_018900.2	NP_061723.1												p.D111N(2)		breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTTGATCGCCGACAGGCCGCT	0.498000													33	29					0	0	1	0	0
STS	412	broad.mit.edu	37	X	7268039	7268039	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chrX:7268039C>A	ENST00000217961.4	+	10	1709	c.1489C>A	c.(1489-1491)Cac>Aac	p.H497N		NM_000351.4	NP_000342.2	P08842	STS_HUMAN	steroid sulfatase (microsomal), isozyme S	497					female pregnancy|steroid catabolic process	endoplasmic reticulum membrane|endosome|Golgi apparatus|integral to membrane|lysosome|microsome|plasma membrane	metal ion binding|steryl-sulfatase activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(10)|prostate(2)|skin(1)	27		Colorectal(8;0.0136)|Medulloblastoma(8;0.184)			Estrone(DB00655)	TGTCACCCATCACGACCCACC	0.493000									Ichthyosis				3	36					0.004672	0.00502421	1	1	0
RBBP8	5932	broad.mit.edu	37	18	20573318	20573318	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr18:20573318G>A	ENST00000399722.2	+	11	1879	c.1528G>A	c.(1528-1530)Gag>Aag	p.E510K	RBBP8_ENST00000360790.5_Missense_Mutation_p.E510K|RBBP8_ENST00000327155.5_Missense_Mutation_p.E510K|RBBP8_ENST00000399725.2_Missense_Mutation_p.E510K	NM_203291.1	NP_976036.1	Q99708	COM1_HUMAN	retinoblastoma binding protein 8	510					cell cycle checkpoint|DNA double-strand break processing involved in repair via single-strand annealing|meiosis|regulation of transcription from RNA polymerase II promoter	nucleus	damaged DNA binding|protein binding|single-stranded DNA specific endodeoxyribonuclease activity			central_nervous_system(1)|cervix(2)|endometrium(5)|large_intestine(2)|lung(9)|ovary(3)|prostate(1)|skin(1)	24	all_cancers(21;4.34e-05)|all_epithelial(16;8.3e-07)|Lung NSC(20;0.0107)|Colorectal(14;0.0202)|all_lung(20;0.0291)|Ovarian(20;0.19)		OV - Ovarian serous cystadenocarcinoma(1;0.00196)			CCAAGGAAGTGAGACTTCTAA	0.423000								Homologous recombination					7	76					0	0	1	0	0
GRIP2	80852	broad.mit.edu	37	3	14552782	14552782	+	RNA	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr3:14552782G>T	ENST00000273083.3	-	0	1888							Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2						synaptic transmission	cytosol|plasma membrane	protein binding			endometrium(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	25						TATTGTCAATGGCCAGTAGCT	0.622000													8	35					1.12685e-05	1.29815e-05	1	1	0
IGHG1	3500	broad.mit.edu	37	14	106204005	106204005	+	RNA	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr14:106204005G>A	ENST00000390548.2	-	0	1293																											GGGCGGTGAGGTCGGGGGCAG	0.682000													7	6					0	0	1	0	0
EED	8726	broad.mit.edu	37	11	85989563	85989563	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr11:85989563G>C	ENST00000263360.6	+	12	2008	c.1322G>C	c.(1321-1323)cGa>cCa	p.R441P	EED_ENST00000351625.6_Missense_Mutation_p.R466P|EED_ENST00000327320.4_3'UTR|EED_ENST00000527888.1_Missense_Mutation_p.R106P|EED_ENST00000528180.1_Missense_Mutation_p.R361P	NM_003797.3	NP_003788.2	O75530	EED_HUMAN	embryonic ectoderm development	441	Interaction with EZH2 (By similarity).|Required for interaction with the matrix protein MA of HIV-1.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|identical protein binding			haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(2)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	21		Acute lymphoblastic leukemia(157;7.24e-07)|all_hematologic(158;0.00092)				GATCGACTTCGATAAAATACT	0.383000													12	45					0	0	1	0	0
MMP3	4314	broad.mit.edu	37	11	102709406	102709406	+	Silent	SNP	G	G	T	rs142121549		TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr11:102709406G>T	ENST00000299855.5	-	8	1361	c.1105C>A	c.(1105-1107)Cga>Aga	p.R369R		NM_002422.3	NP_002413.1	P08254	MMP3_HUMAN	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	369	Hemopexin-like 2.				collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	22		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0142)	Marimastat(DB00786)|Simvastatin(DB00641)	TATCCAGCTCGTACCTCATTT	0.383000													4	46					0.150653	0.15286	1	1	0
COG1	9382	broad.mit.edu	37	17	71192745	71192745	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr17:71192745C>G	ENST00000299886.4	+	2	495	c.415C>G	c.(415-417)Cag>Gag	p.Q139E		NM_018714.2	NP_061184.1	Q8WTW3	COG1_HUMAN	component of oligomeric golgi complex 1	139					Golgi organization|intra-Golgi vesicle-mediated transport|protein transport	Golgi membrane|Golgi transport complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18			LUSC - Lung squamous cell carcinoma(166;0.197)			GGAAGCCTCTCAGTGTCTCCA	0.567000													18	105					0	0	1	0	0
RNF150	57484	broad.mit.edu	37	4	141870482	141870482	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr4:141870482C>G	ENST00000515673.2	-	3	813	c.780G>C	c.(778-780)caG>caC	p.Q260H	RNF150_ENST00000420921.2_Missense_Mutation_p.Q119H|RNF150_ENST00000379512.2_Missense_Mutation_p.Q119H|RNF150_ENST00000306799.3_Missense_Mutation_p.Q218H|RNF150_ENST00000515057.1_5'UTR|RNF150_ENST00000507500.1_Missense_Mutation_p.Q260H			Q9ULK6	RN150_HUMAN	ring finger protein 150							integral to membrane	zinc ion binding			breast(1)|large_intestine(10)|lung(7)|ovary(1)	19	all_hematologic(180;0.162)					TGGTCCTGATCTGGAGTTTGC	0.423000													4	127					0	0	1	0	0
AK3	50808	broad.mit.edu	37	9	4722582	4722582	+	Silent	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr9:4722582G>A	ENST00000381809.3	-	2	425	c.195C>T	c.(193-195)ctC>ctT	p.L65L	AK3_ENST00000447596.4_Intron|AK3_ENST00000359883.2_5'UTR	NM_016282.3	NP_057366.2	Q9UIJ7	KAD3_HUMAN	adenylate kinase 3	65					blood coagulation	mitochondrial matrix	ATP binding|GTP binding|nucleoside triphosphate adenylate kinase activity			large_intestine(2)|lung(1)|ovary(2)	5	all_hematologic(13;0.137)	Breast(48;0.238)		GBM - Glioblastoma multiforme(50;0.0302)		CATCTGGGATGAGTTTCCCTT	0.458000													3	34					0	0	1	0	0
NOB1	28987	broad.mit.edu	37	16	69782871	69782871	+	Missense_Mutation	SNP	C	C	G	rs140707395		TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr16:69782871C>G	ENST00000268802.5	-	6	705	c.676G>C	c.(676-678)Gtc>Ctc	p.V226L		NM_014062.1	NP_054781.1	Q9ULX3	NOB1_HUMAN	NIN1/RPN12 binding protein 1 homolog (S. cerevisiae)	226						nucleus	metal ion binding|protein binding			breast(2)|cervix(1)|endometrium(1)|large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						TCCTCGGGGACGTCACACTGC	0.607000													4	16					0	0	1	0	0
EHMT1	79813	broad.mit.edu	37	9	140611419	140611419	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr9:140611419C>G	ENST00000460843.1	+	3	454	c.427C>G	c.(427-429)Ctg>Gtg	p.L143V	EHMT1_ENST00000334856.6_Missense_Mutation_p.L112V|EHMT1_ENST00000371394.2_3'UTR|EHMT1_ENST00000462484.1_Missense_Mutation_p.L143V	NM_024757.4	NP_079033.4	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	143					DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	41	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		TACCAGCACTCTGGCCTCTTC	0.597000													4	68					0	0	1	0	0
PEX5	5830	broad.mit.edu	37	12	7354881	7354881	+	Silent	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr12:7354881G>T	ENST00000266564.3	+	7	704	c.687G>T	c.(685-687)ctG>ctT	p.L229L	PEX5_ENST00000266563.5_Intron|PEX5_ENST00000412720.2_Silent_p.L250L|PEX5_ENST00000434354.2_Silent_p.L244L|PEX5_ENST00000455147.2_Silent_p.L229L|PEX5_ENST00000545220.1_3'UTR|PEX5_ENST00000420616.2_Silent_p.L229L	NM_000319.4	NP_000310.2	P50542	PEX5_HUMAN	peroxisomal biogenesis factor 5	229					protein import into peroxisome matrix, translocation|protein targeting to peroxisome|protein tetramerization|protein transport	cytosol|peroxisomal matrix|peroxisomal membrane	peroxisome matrix targeting signal-1 binding|protein C-terminus binding|protein N-terminus binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)	21						AGGTGTCCCTGGAGTCCGGTG	0.577000													8	37					0.0477658	0.0495008	1	1	0
MYH3	4621	broad.mit.edu	37	17	10545813	10545813	+	Silent	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr17:10545813G>A	ENST00000583535.1	-	16	1896	c.1809C>T	c.(1807-1809)aaC>aaT	p.N603N	MYH3_ENST00000226209.7_Silent_p.N603N	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	603	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						CCACAGTCTCGTTCAGAGGGT	0.562000													29	31					0	0	1	0	0
SMPD2	6610	broad.mit.edu	37	6	109765033	109765033	+	Silent	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:109765033C>T	ENST00000258052.3	+	10	1556	c.1197C>T	c.(1195-1197)gcC>gcT	p.A399A		NM_003080.2	NP_003071.2	O60906	NSMA_HUMAN	sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)	399					induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|sphingomyelin metabolic process	integral to plasma membrane	metal ion binding|sphingomyelin phosphodiesterase activity			endometrium(2)|lung(3)|stomach(1)|upper_aerodigestive_tract(2)	8		all_cancers(87;1.1e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000144)|all_lung(197;0.0221)|Colorectal(196;0.0488)|Lung SC(18;0.0548)		Epithelial(106;0.0137)|all cancers(137;0.0188)|OV - Ovarian serous cystadenocarcinoma(136;0.0228)|BRCA - Breast invasive adenocarcinoma(108;0.0566)		CAAGGGAGGCCCAGGATCTGG	0.582000													13	42					0	0	1	0	0
ZNF407	55628	broad.mit.edu	37	18	72344821	72344821	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr18:72344821C>A	ENST00000299687.5	+	1	1846	c.1846C>A	c.(1846-1848)Ctt>Att	p.L616I	ZNF407_ENST00000577538.1_Missense_Mutation_p.L616I|ZNF407_ENST00000582337.1_Missense_Mutation_p.L616I|ZNF407_ENST00000309902.6_Missense_Mutation_p.L616I	NM_017757.2	NP_060227.2	Q9C0G0	ZN407_HUMAN	zinc finger protein 407	616					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.L616V(2)		central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(21)|lung(23)|ovary(4)|prostate(3)|upper_aerodigestive_tract(2)	67		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		TATGCATTTTCTTTGCACCCC	0.368000													32	61					8.16721e-17	1.02619e-16	1	1	0
MAPKAPK3	7867	broad.mit.edu	37	3	50677925	50677925	+	Silent	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr3:50677925C>T	ENST00000446044.1	+	5	944	c.348C>T	c.(346-348)atC>atT	p.I116I	MAPKAPK3_ENST00000357955.2_Silent_p.I116I	NM_001243926.1	NP_001230855.1	Q16644	MAPK3_HUMAN	mitogen-activated protein kinase-activated protein kinase 3	116	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity			central_nervous_system(1)|ovary(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.0188)|Kidney(197;0.0223)		GTCTCCTCATCATCATGGAAT	0.572000													31	144					0	0	1	0	0
GCLC	2729	broad.mit.edu	37	6	53373430	53373430	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:53373430G>A	ENST00000229416.6	-	8	1391	c.908C>T	c.(907-909)tCt>tTt	p.S303F		NM_001197115.1|NM_001498.3	NP_001184044.1|NP_001489.1	P48506	GSH1_HUMAN	glutamate-cysteine ligase, catalytic subunit	303					anti-apoptosis|cell redox homeostasis|cysteine metabolic process|glutamate metabolic process|glutathione biosynthetic process|negative regulation of transcription, DNA-dependent|regulation of blood vessel size|response to heat|response to hormone stimulus|response to oxidative stress|xenobiotic metabolic process	cytosol	ADP binding|ATP binding|coenzyme binding|glutamate binding|glutamate-cysteine ligase activity|magnesium ion binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22	Lung NSC(77;0.0137)				L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)	ATCATCTACAGATGCAGAAAT	0.433000													59	73					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53854332	53854332	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr19:53854332C>A	ENST00000458035.1	+	4	521	c.404C>A	c.(403-405)cCt>cAt	p.P135H	ZNF845_ENST00000595091.1_Missense_Mutation_p.P135H	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	135					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						GGAAACAAGCCTATTAAAGAT	0.413000													54	242					6.3091e-27	8.13807e-27	1	1	0
CAMLG	819	broad.mit.edu	37	5	134074346	134074346	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr5:134074346G>C	ENST00000297156.2	+	1	156	c.36G>C	c.(34-36)gaG>gaC	p.E12D	CAMLG_ENST00000514518.1_Missense_Mutation_p.E12D	NM_001745.3	NP_001736.1	P49069	CAMLG_HUMAN	calcium modulating ligand	12					defense response	endoplasmic reticulum|integral to membrane				NS(1)|cervix(1)|kidney(3)|lung(3)|prostate(1)	9			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		Cyclosporine(DB00091)	ACGGCGGGGAGAGGCCGGGGG	0.687000													7	6					0	0	1	0	0
CEMP1	752014	broad.mit.edu	37	16	2580867	2580867	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr16:2580867G>T	ENST00000382350.1	-	1	553	c.208C>A	c.(208-210)Cac>Aac	p.H70N	AMDHD2_ENST00000413459.3_3'UTR|AMDHD2_ENST00000302956.4_3'UTR|CEMP1_ENST00000567119.1_Missense_Mutation_p.H70N|AMDHD2_ENST00000565570.1_3'UTR|CEMP1_ENST00000565480.1_Intron			Q6PRD7	CEMP1_HUMAN	cementum protein 1	70						cytoplasm				lung(1)|skin(1)	2						TGAGAGGTGTGAGGTGCAGGG	0.657000													6	32					3.59834e-05	4.10634e-05	1	1	0
SLC7A5	8140	broad.mit.edu	37	16	87902738	87902738	+	Silent	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr16:87902738G>A	ENST00000261622.4	-	1	356	c.291C>T	c.(289-291)atC>atT	p.I97I		NM_003486.5	NP_003477.4	Q01650	LAT1_HUMAN	solute carrier family 7 (amino acid transporter light chain, L system), member 5	97					blood coagulation|cell differentiation|cellular amino acid metabolic process|ion transport|leukocyte migration|nervous system development	apical plasma membrane|cytosol|integral to membrane	neutral amino acid transmembrane transporter activity|peptide antigen binding			endometrium(3)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	10				BRCA - Breast invasive adenocarcinoma(80;0.049)		GCGCGCCCACGATGGAGAAGA	0.701000													27	21					0	0	1	0	0
WIPI2	26100	broad.mit.edu	37	7	5269364	5269364	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr7:5269364G>C	ENST00000288828.4	+	12	1479	c.1247G>C	c.(1246-1248)aGa>aCa	p.R416T	WIPI2_ENST00000382384.2_Intron|WIPI2_ENST00000484262.1_Intron|WIPI2_ENST00000401525.3_Missense_Mutation_p.R398T|WIPI2_ENST00000404704.3_Intron	NM_001033518.1|NM_001278299.1|NM_015610.3	NP_001028690.1|NP_001265228.1|NP_056425.1	Q9Y4P8	WIPI2_HUMAN	WD repeat domain, phosphoinositide interacting 2	416					autophagic vacuole assembly	cytosol|PAS complex|pre-autophagosomal structure membrane	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)	16		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0925)|OV - Ovarian serous cystadenocarcinoma(56;2.59e-14)		TCCCCAACGAGACTTGGTAAG	0.577000													3	11					0	0	1	0	0
EXOC6B	23233	broad.mit.edu	37	2	72722561	72722561	+	Silent	SNP	T	T	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr2:72722561T>C	ENST00000272427.6	-	15	1681	c.1551A>G	c.(1549-1551)ctA>ctG	p.L517L	EXOC6B_ENST00000410104.1_Silent_p.L517L	NM_015189.1	NP_056004.1	Q9Y2D4	EXC6B_HUMAN	exocyst complex component 6B	517					protein transport|vesicle docking involved in exocytosis	exocyst				breast(1)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)	10						TATTATACCTTAGATGAAGAT	0.318000													4	10					0	0	1	0	0
POTEH	23784	broad.mit.edu	37	22	16287676	16287676	+	Silent	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr22:16287676G>A	ENST00000343518.6	-	1	261	c.210C>T	c.(208-210)ccC>ccT	p.P70P		NM_001136213.1	NP_001129685.1	Q6S545	POTEH_HUMAN	POTE ankyrin domain family, member H	70										NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(20)|ovary(1)|skin(7)|urinary_tract(2)	37						CCCTGCACCAGGGGAAGCAGT	0.587000													129	468					0	0	1	0	0
WDFY3	23001	broad.mit.edu	37	4	85600134	85600134	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr4:85600134C>A	ENST00000322366.6	-	64	10441	c.10034G>T	c.(10033-10035)gGc>gTc	p.G3345V	WDFY3_ENST00000295888.4_Missense_Mutation_p.G3362V			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	3362						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		GCTAAGGGGGCCCTGCAGATG	0.512000													14	56					1.05317e-09	1.28339e-09	1	1	0
SIRT7	51547	broad.mit.edu	37	17	79872379	79872379	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr17:79872379C>T	ENST00000328666.6	-	7	669	c.607G>A	c.(607-609)Gag>Aag	p.E203K		NM_016538.2	NP_057622.1	Q9NRC8	SIRT7_HUMAN	sirtuin 7	203	Deacetylase sirtuin-type.				chromatin silencing|positive regulation of transcription on exit from mitosis|protein deacetylation|rRNA transcription	cytoplasm|nucleolus organizer region	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ binding|protein binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	13	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.0165)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			CGCACGTACTCCCTGTTGGGA	0.642000													14	52					0	0	1	0	0
MIR621	693206	broad.mit.edu	37	13	41384975	41384975	+	RNA	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr13:41384975G>A	ENST00000384919.1	+	0	74					NR_030352.1																						TAGCAACAGCGCTTACCTTTT	0.547000													4	52					0	0	1	0	0
SPHK2	56848	broad.mit.edu	37	19	49130977	49130977	+	Silent	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr19:49130977G>T	ENST00000443164.1	+	2	1431	c.726G>T	c.(724-726)ccG>ccT	p.P242P	SPHK2_ENST00000599748.1_Silent_p.P144P|SPHK2_ENST00000598088.1_Silent_p.P180P|SPHK2_ENST00000599029.1_Silent_p.P144P|SPHK2_ENST00000340932.3_Silent_p.P144P|SPHK2_ENST00000601712.1_Silent_p.P144P|SPHK2_ENST00000600537.1_Silent_p.P121P|SPHK2_ENST00000245222.4_Silent_p.P180P			Q9NRA0	SPHK2_HUMAN	sphingosine kinase 2	180	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cell proliferation|sphinganine-1-phosphate biosynthetic process	cytosol|lysosomal membrane|membrane fraction	ATP binding|D-erythro-sphingosine kinase activity|diacylglycerol kinase activity|Ras GTPase binding|sphinganine kinase activity			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(4)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	19		all_lung(116;0.000125)|Lung NSC(112;0.000202)|all_epithelial(76;0.000283)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		TACCTCGGCCGCCCCGGTTGC	0.602000													4	175					0.150653	0.15286	1	1	0
OR8G5	219865	broad.mit.edu	37	11	124135564	124135564	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr11:124135564C>T	ENST00000524943.2	+	1	842	c.842C>T	c.(841-843)tCg>tTg	p.S281L	OR8G1_ENST00000341493.2_RNA	NM_001005198.1	NP_001005198.1			olfactory receptor, family 8, subfamily G, member 5														Breast(109;0.0157)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0523)		TCCCACATCTCGGCTGTTTCT	0.507000													27	96					0	0	1	0	0
FBXL19	54620	broad.mit.edu	37	16	30941554	30941554	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr16:30941554C>T	ENST00000338343.4	+	7	1337	c.950C>T	c.(949-951)tCg>tTg	p.S317L	FBXL19_ENST00000562319.1_Missense_Mutation_p.S317L|FBXL19_ENST00000380310.2_Missense_Mutation_p.S337L|FBXL19_ENST00000565690.1_Missense_Mutation_p.S201L|FBXL19_ENST00000471231.2_Missense_Mutation_p.S25L			Q6PCT2	FXL19_HUMAN	F-box and leucine-rich repeat protein 19	337							DNA binding|zinc ion binding			breast(2)|endometrium(3)|lung(5)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	16						TCCGACTCTTCGGGCACATCG	0.667000													12	49					0	0	1	0	0
FOXP1	27086	broad.mit.edu	37	3	71021828	71021828	+	Splice_Site	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr3:71021828C>G	ENST00000318789.4	-	18	2056		c.e18-1		FOXP1_ENST00000493089.1_Splice_Site|FOXP1_ENST00000484350.1_Splice_Site|FOXP1_ENST00000491238.1_Splice_Site|FOXP1_ENST00000468577.1_Intron|FOXP1_ENST00000498215.1_Splice_Site|FOXP1_ENST00000475937.1_Splice_Site	NM_001244810.1|NM_001244813.1|NM_032682.5	NP_001231739.1|NP_001231742.1|NP_116071.2	Q9H334	FOXP1_HUMAN	forkhead box P1						cardiac muscle cell differentiation|embryo development|immunoglobulin V(D)J recombination|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of immunoglobulin production|positive regulation of mesenchymal cell proliferation|pre-B cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|skeletal muscle tissue development|smooth muscle tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	31		Lung NSC(201;4.62e-05)|Prostate(10;0.0181)|Hepatocellular(537;0.186)|Myeloproliferative disorder(1037;0.209)		BRCA - Breast invasive adenocarcinoma(55;1.17e-05)|Epithelial(33;1.39e-05)|LUSC - Lung squamous cell carcinoma(21;2.35e-05)|Lung(16;4.26e-05)		GCACTGCATTCTGCAGCAAGT	0.368000			T	PAX5	ALL								7	60					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51174230	51174230	+	Missense_Mutation	SNP	G	G	T	rs61731136	byFrequency	TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr16:51174230G>T	ENST00000440970.1	-	2	2043	c.1612C>A	c.(1612-1614)Ccg>Acg	p.P538T	SALL1_ENST00000251020.4_Missense_Mutation_p.P635T|SALL1_ENST00000566102.1_Intron|SALL1_ENST00000541611.1_Intron	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	635					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			CTCGCCGTCGGGACTGAGTTG	0.632000													6	36					4.3838e-07	5.1731e-07	1	1	0
RAD54L2	23132	broad.mit.edu	37	3	51669661	51669661	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr3:51669661G>T	ENST00000409535.2	+	9	1320	c.1195G>T	c.(1195-1197)Gtg>Ttg	p.V399L	RAD54L2_ENST00000296477.3_Missense_Mutation_p.V93L	NM_015106.2	NP_055921.2	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2 (S. cerevisiae)		Helicase ATP-binding.					nucleus	ATP binding|DNA binding|helicase activity			NS(2)|breast(1)|cervix(2)|endometrium(4)|large_intestine(5)|liver(2)|lung(9)|ovary(4)|skin(2)	31				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)		AGAGGGTGGCGTGCTGCTGAT	0.468000													9	46					0.0477658	0.0495008	1	1	0
ZNF407	55628	broad.mit.edu	37	18	72346054	72346054	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr18:72346054C>T	ENST00000299687.5	+	1	3079	c.3079C>T	c.(3079-3081)Cac>Tac	p.H1027Y	ZNF407_ENST00000577538.1_Missense_Mutation_p.H1027Y|ZNF407_ENST00000582337.1_Missense_Mutation_p.H1027Y|ZNF407_ENST00000309902.6_Missense_Mutation_p.H1027Y	NM_017757.2	NP_060227.2	Q9C0G0	ZN407_HUMAN	zinc finger protein 407	1027					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(21)|lung(23)|ovary(4)|prostate(3)|upper_aerodigestive_tract(2)	67		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		GTTTAGTGCTCACTCCTCTGC	0.488000													32	64					0	0	1	0	0
GPR63	81491	broad.mit.edu	37	6	97246729	97246729	+	Silent	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:97246729G>A	ENST00000229955.3	-	2	1224	c.879C>T	c.(877-879)ctC>ctT	p.L293L	GPR63_ENST00000417980.1_Silent_p.L293L	NM_001143957.2|NM_030784.3	NP_001137429.1|NP_110411.1	Q9BZJ6	GPR63_HUMAN	G protein-coupled receptor 63	293						integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			kidney(1)|large_intestine(5)|lung(13)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		all_cancers(76;6.89e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0618)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0912)		GCAGACTCATGAGACCCAGTT	0.473000													17	45					0	0	1	0	0
FER	2241	broad.mit.edu	37	5	108290593	108290593	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr5:108290593C>T	ENST00000281092.4	+	12	1877	c.1493C>T	c.(1492-1494)tCt>tTt	p.S498F	FER_ENST00000438717.2_Missense_Mutation_p.S323F|FER_ENST00000536402.1_Intron	NM_005246.2	NP_005237.2	P16591	FER_HUMAN	fer (fps/fes related) tyrosine kinase	498	SH2.				intracellular signal transduction|peptidyl-tyrosine phosphorylation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			NS(2)|biliary_tract(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(12)|ovary(1)|skin(2)|stomach(1)|urinary_tract(2)	32		all_cancers(142;2.86e-06)|all_epithelial(76;9.81e-08)|Prostate(80;0.00972)|Lung NSC(167;0.039)|Ovarian(225;0.0448)|all_lung(232;0.0496)|Colorectal(57;0.0986)|Breast(839;0.152)		OV - Ovarian serous cystadenocarcinoma(64;6.77e-10)|Epithelial(69;4.13e-08)|COAD - Colon adenocarcinoma(37;0.0174)		TCTGTATATTCTGATGGACAG	0.348000													15	35					0	0	1	0	0
C19orf44	84167	broad.mit.edu	37	19	16612137	16612137	+	Silent	SNP	A	A	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr19:16612137A>G	ENST00000221671.3	+	2	690	c.534A>G	c.(532-534)caA>caG	p.Q178Q	C19orf44_ENST00000594035.1_Silent_p.Q178Q|CTD-3222D19.2_ENST00000409035.1_Intron	NM_032207.2	NP_115583.1	Q9H6X5	CS044_HUMAN	chromosome 19 open reading frame 44	178										endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|stomach(1)|urinary_tract(2)	16						AGAAGAAACAAGCACCTGTTG	0.448000													40	21					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25449362	25449362	+	RNA	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr15:25449362G>C	ENST00000424208.1	+	0	2254				SNHG14_ENST00000424333.1_RNA	NR_003305.1																						CTGGCCCCACGTCAGTGTTCG	0.612000													10	20					0	0	1	0	0
BTBD3	22903	broad.mit.edu	37	20	11904279	11904279	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr20:11904279G>A	ENST00000405977.1	+	5	2159	c.1534G>A	c.(1534-1536)Gga>Aga	p.G512R	BTBD3_ENST00000378226.2_Missense_Mutation_p.G512R|BTBD3_ENST00000254977.3_Missense_Mutation_p.G451R|BTBD3_ENST00000399006.2_Missense_Mutation_p.G451R	NM_001282550.1|NM_001282552.1|NM_001282554.1	NP_001269479.1|NP_001269481.1|NP_001269483.1	Q9Y2F9	BTBD3_HUMAN	BTB (POZ) domain containing 3	512								p.G512R(1)		breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(18)|ovary(3)|skin(2)	34						TGGGGTACAGGGAGGGCAGAT	0.483000													31	46					0	0	1	0	0
KHDRBS2	202559	broad.mit.edu	37	6	62604676	62604676	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:62604676C>T	ENST00000281156.4	-	6	952	c.674G>A	c.(673-675)gGa>gAa	p.G225E		NM_152688.2	NP_689901.2	Q5VWX1	KHDR2_HUMAN	KH domain containing, RNA binding, signal transduction associated 2	225	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(5)|liver(1)|lung(13)|ovary(3)|prostate(3)|skin(12)|upper_aerodigestive_tract(2)|urinary_tract(1)	49				BRCA - Breast invasive adenocarcinoma(397;0.149)		TACAGTGCTTCCCCGAGGGGT	0.607000													6	15					0	0	1	0	0
MBD5	55777	broad.mit.edu	37	2	149220179	149220179	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr2:149220179G>C	ENST00000407073.1	+	7	1139	c.142G>C	c.(142-144)Gag>Cag	p.E48Q	MBD5_ENST00000404807.1_Missense_Mutation_p.E48Q	NM_018328.4	NP_060798.2	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	48	MBD.					chromosome|nucleus	chromatin binding|DNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(16)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	62				BRCA - Breast invasive adenocarcinoma(221;0.0569)		ATCTTGCTTGGAGCAGGTTAA	0.348000													3	82					0	0	1	0	0
TFIP11	24144	broad.mit.edu	37	22	26895343	26895343	+	Silent	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr22:26895343G>C	ENST00000407690.1	-	9	1339	c.1056C>G	c.(1054-1056)ctC>ctG	p.L352L	TFIP11_ENST00000407148.1_Silent_p.L352L|TFIP11_ENST00000405938.1_Silent_p.L352L|TFIP11_ENST00000407431.1_Silent_p.L352L	NM_012143.2	NP_036275.1	Q9UBB9	TFP11_HUMAN	tuftelin interacting protein 11	352					biomineral tissue development	catalytic step 2 spliceosome|cytoplasm|nuclear speck	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(5)|liver(1)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	25						GCTCGTGGAAGAGGTTGACCA	0.597000													20	84					0	0	1	0	0
PSMC2	5701	broad.mit.edu	37	7	103007950	103007950	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr7:103007950G>C	ENST00000435765.1	+	11	1346	c.935G>C	c.(934-936)aGa>aCa	p.R312T	SLC26A5_ENST00000339444.6_Intron|PSMC2_ENST00000544811.1_Missense_Mutation_p.R175T|SLC26A5_ENST00000393735.2_Intron|PSMC2_ENST00000292644.3_Missense_Mutation_p.R312T|SLC26A5_ENST00000356767.4_Intron	NM_002803.3	NP_002794.1	P35998	PRS7_HUMAN	proteasome (prosome, macropain) 26S subunit, ATPase, 2	312					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding			breast(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	21						TTTGATCCTAGAGGCAATATT	0.438000													13	42					0	0	1	0	0
RNF166	115992	broad.mit.edu	37	16	88767739	88767739	+	Silent	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr16:88767739C>T	ENST00000312838.4	-	2	338	c.243G>A	c.(241-243)gtG>gtA	p.V81V	RNF166_ENST00000541206.2_5'UTR|RNF166_ENST00000562499.1_5'UTR|RNF166_ENST00000567844.1_Intron	NM_178841.3	NP_849163.1	Q96A37	RN166_HUMAN	ring finger protein 166	81						intracellular	zinc ion binding			endometrium(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0476)		TGGCCTTGTCCACCTTCTTGG	0.657000													8	46					0	0	1	0	0
LRRC36	55282	broad.mit.edu	37	16	67401082	67401082	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr16:67401082C>T	ENST00000329956.6	+	8	936	c.917C>T	c.(916-918)tCa>tTa	p.S306L	LRRC36_ENST00000563189.1_Missense_Mutation_p.S185L|LRRC36_ENST00000290940.7_Missense_Mutation_p.S38L|LRRC36_ENST00000435835.3_Missense_Mutation_p.S185L|LRRC36_ENST00000541146.1_Intron	NM_018296.5	NP_060766.5	Q1X8D7	LRC36_HUMAN	leucine rich repeat containing 36	306										endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	24		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0669)|Epithelial(162;0.161)		CATGATGCCTCATTGAGTAAA	0.393000													6	117					0	0	1	0	0
ACTN3	89	broad.mit.edu	37	11	66323656	66323656	+	RNA	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr11:66323656G>A	ENST00000502692.1	+	0	1004				ACTN3_ENST00000513398.1_RNA	NM_001258371.1	NP_001245300.1	Q08043	ACTN3_HUMAN	actinin, alpha 3 (gene/pseudogene)						focal adhesion assembly|muscle filament sliding|regulation of apoptosis	actin filament|cytosol|focal adhesion|pseudopodium	actin binding|calcium ion binding|integrin binding|protein homodimerization activity|structural constituent of muscle			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(2)	10						AGGCCATCATGACCTATGTGT	0.607000													21	108					0	0	1	0	0
HIVEP2	3097	broad.mit.edu	37	6	143093331	143093331	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:143093331C>G	ENST00000367603.2	-	5	3287	c.2545G>C	c.(2545-2547)Gag>Cag	p.E849Q	HIVEP2_ENST00000367604.1_Missense_Mutation_p.E849Q|HIVEP2_ENST00000012134.2_Missense_Mutation_p.E849Q	NM_006734.3	NP_006725.3	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer binding protein 2	849					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(4)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(19)|lung(35)|ovary(4)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	100				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		GGAGCCCACTCAGGACTCACT	0.562000													14	45					0	0	1	0	0
WIPI2	26100	broad.mit.edu	37	7	5269255	5269255	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr7:5269255G>C	ENST00000288828.4	+	12	1370	c.1138G>C	c.(1138-1140)Gaa>Caa	p.E380Q	WIPI2_ENST00000382384.2_Missense_Mutation_p.E362Q|WIPI2_ENST00000484262.1_Missense_Mutation_p.E321Q|WIPI2_ENST00000401525.3_Missense_Mutation_p.E362Q|WIPI2_ENST00000404704.3_Missense_Mutation_p.E380Q	NM_001033518.1|NM_001278299.1|NM_015610.3	NP_001028690.1|NP_001265228.1|NP_056425.1	Q9Y4P8	WIPI2_HUMAN	WD repeat domain, phosphoinositide interacting 2	380				E -> K (in Ref. 2; AAD34045).	autophagic vacuole assembly	cytosol|PAS complex|pre-autophagosomal structure membrane	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)	16		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0925)|OV - Ovarian serous cystadenocarcinoma(56;2.59e-14)		CGGCAGTCTGGAAACGACCAA	0.587000													4	7					0	0	1	0	0
IPO5	3843	broad.mit.edu	37	13	98664545	98664545	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr13:98664545G>C	ENST00000261574.5	+	21	2335	c.2155G>C	c.(2155-2157)Gaa>Caa	p.E719Q	IPO5_ENST00000490680.1_Missense_Mutation_p.E701Q|IPO5_ENST00000539640.1_Missense_Mutation_p.E576Q	NM_002271.4	NP_002262.3	O00410	IPO5_HUMAN	importin 5	701					interspecies interaction between organisms|NLS-bearing substrate import into nucleus|ribosomal protein import into nucleus	cytoplasm|nuclear pore|nucleolus	GTPase inhibitor activity|protein transporter activity|Ran GTPase binding			breast(2)|endometrium(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	27						GGAGTACACCGAACAGGTTGT	0.358000													3	73					0	0	1	0	0
NRAS	4893	broad.mit.edu	37	1	115252309	115252309	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr1:115252309T>C	ENST00000369535.4	-	4	584	c.331A>G	c.(331-333)Atg>Gtg	p.M111V		NM_002524.4	NP_002515.1	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	111					activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity			NS(134)|adrenal_gland(9)|autonomic_ganglia(9)|biliary_tract(6)|bone(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(11)|eye(3)|haematopoietic_and_lymphoid_tissue(1115)|kidney(3)|large_intestine(105)|liver(10)|lung(42)|meninges(2)|ovary(7)|pancreas(5)|prostate(8)|skin(1144)|soft_tissue(37)|stomach(5)|testis(8)|thyroid(359)|upper_aerodigestive_tract(28)|urinary_tract(13)	3085	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACTAGCACCATAGGTACATCA	0.418000		50	Mis		"""melanoma, MM, AML, thyroid"""				Noonan syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			27	23					0	0	1	0	0
PCDHB11	56125	broad.mit.edu	37	5	140581588	140581588	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr5:140581588G>C	ENST00000354757.3	+	1	2241	c.2241G>C	c.(2239-2241)caG>caC	p.Q747H	PCDHB11_ENST00000536699.1_Missense_Mutation_p.Q382H	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		747					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCTTTCCCAGAGCTACCAGT	0.582000													18	69					0	0	1	0	0
FSD2	123722	broad.mit.edu	37	15	83440883	83440883	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr15:83440883C>G	ENST00000334574.8	-	7	1390	c.1209G>C	c.(1207-1209)gaG>gaC	p.E403D	FSD2_ENST00000541889.1_Missense_Mutation_p.E403D			A1L4K1	FSD2_HUMAN	fibronectin type III and SPRY domain containing 2	403	Fibronectin type-III 1.									breast(2)|central_nervous_system(1)|large_intestine(5)|lung(10)	18						GCTGATAGCTCTCCACAGTGT	0.572000													9	22					0	0	1	0	0
HIVEP2	3097	broad.mit.edu	37	6	143095356	143095356	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:143095356C>T	ENST00000367603.2	-	5	1262	c.520G>A	c.(520-522)Gaa>Aaa	p.E174K	HIVEP2_ENST00000367604.1_Missense_Mutation_p.E174K|HIVEP2_ENST00000012134.2_Missense_Mutation_p.E174K	NM_006734.3	NP_006725.3	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer binding protein 2	174					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(4)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(19)|lung(35)|ovary(4)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	100				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		TGAGCCTCTTCTGCCTGTTCA	0.433000													38	145					0	0	1	0	0
BNC1	646	broad.mit.edu	37	15	83926593	83926593	+	Silent	SNP	C	C	A	rs142800358		TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr15:83926593C>A	ENST00000345382.2	-	5	2671	c.2586G>T	c.(2584-2586)tcG>tcT	p.S862S	BNC1_ENST00000569704.1_Silent_p.S855S|RP11-382A20.4_ENST00000565495.1_RNA	NM_001717.3	NP_001708.3	Q01954	BNC1_HUMAN	basonuclin 1	862	Ser-rich.				epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	56						ACTTCATGCTCGAGGTAGTGC	0.547000													5	57					4.096e-09	4.9664e-09	1	1	0
ANK2	287	broad.mit.edu	37	4	114278500	114278500	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr4:114278500C>A	ENST00000357077.4	+	38	8779	c.8726C>A	c.(8725-8727)cCc>cAc	p.P2909H	ANK2_ENST00000394537.3_Intron|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000509550.1_Intron|ANK2_ENST00000264366.6_Missense_Mutation_p.P2876H|ANK2_ENST00000510275.2_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2876					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		ATGGATGTTCCCGTGTCTGAC	0.398000													6	148					0.00116845	0.00127062	1	1	0
UGT3A2	167127	broad.mit.edu	37	5	36035883	36035883	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr5:36035883G>T	ENST00000282507.3	-	7	1590	c.1489C>A	c.(1489-1491)Ctg>Atg	p.L497M	UGT3A2_ENST00000545528.1_Missense_Mutation_p.L195M|UGT3A2_ENST00000513300.1_Missense_Mutation_p.L463M	NM_174914.3	NP_777574.2	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	497						integral to membrane	glucuronosyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	43	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AGAGTCCCCAGAGTGAGCCCC	0.597000													28	17					1.33986e-20	1.7146e-20	1	1	0
CNTNAP4	85445	broad.mit.edu	37	16	76555101	76555101	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr16:76555101C>A	ENST00000307431.8	+	17	2812	c.2427C>A	c.(2425-2427)caC>caA	p.H809Q	CNTNAP4_ENST00000478060.1_Missense_Mutation_p.H737Q|CNTNAP4_ENST00000377504.4_Missense_Mutation_p.H761Q|CNTNAP4_ENST00000476707.1_Missense_Mutation_p.H813Q|CNTNAP4_ENST00000469589.1_3'UTR	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	810	Laminin G-like 3.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						CTACCTTCCACGGAGAACTTA	0.363000													7	172					8.12818e-05	9.16784e-05	1	1	0
WDR93	56964	broad.mit.edu	37	15	90245194	90245194	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr15:90245194G>A	ENST00000268130.7	+	2	318	c.217G>A	c.(217-219)Gaa>Aaa	p.E73K	WDR93_ENST00000558000.1_Missense_Mutation_p.E73K|WDR93_ENST00000560294.1_Missense_Mutation_p.E73K	NM_020212.1	NP_064597.1	Q6P2C0	WDR93_HUMAN	WD repeat domain 93	73					electron transport chain	mitochondrial inner membrane	oxidoreductase activity, acting on NADH or NADPH			NS(1)|breast(3)|endometrium(2)|kidney(4)|large_intestine(5)|liver(2)|lung(8)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	33	Lung NSC(78;0.0237)|all_lung(78;0.0478)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|BRCA - Breast invasive adenocarcinoma(143;0.128)			CCAGTCTTGGGAAATTATTGA	0.502000													4	21					0	0	1	0	0
EPS8L1	54869	broad.mit.edu	37	19	55591149	55591149	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr19:55591149G>C	ENST00000201647.6	+	5	265	c.209G>C	c.(208-210)cGa>cCa	p.R70P	EPS8L1_ENST00000540810.1_Missense_Mutation_p.R6P|EPS8L1_ENST00000592824.1_3'UTR|EPS8L1_ENST00000586329.1_Missense_Mutation_p.R52P	NM_133180.2	NP_573441.2	Q8TE68	ES8L1_HUMAN	EPS8-like 1	70						cytoplasm				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(2)|lung(3)|ovary(1)|prostate(1)	12			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		AGCCAGGGCCGAGTCTGGGCA	0.657000													10	34					0	0	1	0	0
VPS11	55823	broad.mit.edu	37	11	118949691	118949691	+	Silent	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr11:118949691C>T	ENST00000300793.6	+	14	2289	c.2247C>T	c.(2245-2247)ctC>ctT	p.L749L	VPS11_ENST00000527798.1_3'UTR	NM_021729.4	NP_068375.3	Q9H270	VPS11_HUMAN	vacuolar protein sorting 11 homolog (S. cerevisiae)	750					protein transport	endocytic vesicle|HOPS complex|late endosome membrane|lysosomal membrane	nucleotide binding|protein binding|zinc ion binding			autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)|skin(2)|urinary_tract(2)	29	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.88e-05)		ACAAGAACCTCATGCCACCTC	0.562000													21	65					0	0	1	0	0
MIR1275	100302123	broad.mit.edu	37	6	33967754	33967754	+	RNA	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:33967754C>G	ENST00000408770.1	-	0	74					NR_031681.1																						TGAGTTCCCTCTGCCTTGGGG	0.507000													8	32					0	0	1	0	0
PPP2R2B	5521	broad.mit.edu	37	5	146030241	146030241	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr5:146030241C>G	ENST00000394413.3	-	5	1064	c.494G>C	c.(493-495)cGa>cCa	p.R165P	PPP2R2B_ENST00000394409.3_Missense_Mutation_p.R223P|PPP2R2B_ENST00000356826.3_Missense_Mutation_p.R165P|PPP2R2B_ENST00000530902.1_5'UTR|PPP2R2B_ENST00000394410.2_Missense_Mutation_p.R154P|PPP2R2B_ENST00000394414.1_Missense_Mutation_p.R231P|PPP2R2B_ENST00000336640.6_Missense_Mutation_p.R168P|PPP2R2B_ENST00000504198.1_Missense_Mutation_p.R171P|PPP2R2B_ENST00000394411.4_Missense_Mutation_p.R165P|PPP2R2B_ENST00000453001.1_Missense_Mutation_p.R165P|PPP2R2B_ENST00000508545.2_Missense_Mutation_p.R154P			Q00005	2ABB_HUMAN	protein phosphatase 2, regulatory subunit B, beta	165					apoptosis|signal transduction	cytoskeleton|mitochondrial outer membrane|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(9)|ovary(1)|prostate(4)|skin(3)	32			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AAATACTCTTCGTGGGGTGGC	0.473000													4	32					0	0	1	0	0
C2CD2	25966	broad.mit.edu	37	21	43332457	43332457	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr21:43332457C>T	ENST00000380486.3	-	7	1178	c.937G>A	c.(937-939)Gaa>Aaa	p.E313K	C2CD2_ENST00000329623.7_Missense_Mutation_p.E158K	NM_015500.1	NP_056315.1	Q9Y426	CU025_HUMAN	C2 calcium-dependent domain containing 2	313	C2.					cytosol|extracellular region|nucleus				endometrium(2)|kidney(1)|large_intestine(4)|lung(3)|ovary(3)|prostate(1)|stomach(1)	15						AATTCCTCTTCCCACATGAGG	0.537000													4	31					0	0	1	0	0
MIR99AHG	388815	broad.mit.edu	37	21	17962583	17962583	+	RNA	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr21:17962583C>A	ENST00000458468.1	+	0	579				MIR125B2_ENST00000385128.1_RNA	NR_027790.1																						TCCCTGAGACCCTAACTTGTG	0.433000													10	81					0.010729	0.0113615	1	1	0
TRERF1	55809	broad.mit.edu	37	6	42236621	42236621	+	Silent	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:42236621G>A	ENST00000541110.1	-	5	1276	c.708C>T	c.(706-708)taC>taT	p.Y236Y	TRERF1_ENST00000340840.2_Silent_p.Y236Y|TRERF1_ENST00000354325.2_Silent_p.Y236Y|TRERF1_ENST00000372922.4_Silent_p.Y236Y|TRERF1_ENST00000372917.4_Silent_p.Y236Y			Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	236	Gln-rich.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(1)|large_intestine(12)|lung(13)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(2)	45	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			GAGGCTGCTGGTAGTCATAAT	0.597000													26	51					0	0	1	0	0
C1orf131	128061	broad.mit.edu	37	1	231360132	231360132	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr1:231360132T>C	ENST00000366651.3	-	7	808	c.772A>G	c.(772-774)Att>Gtt	p.I258V	C1orf131_ENST00000318906.2_3'UTR|C1orf131_ENST00000366649.2_Missense_Mutation_p.I259V	NM_152379.2	NP_689592.2	Q8NDD1	CA131_HUMAN	chromosome 1 open reading frame 131	260										breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(1)	8	Breast(184;0.0871)	all_cancers(173;0.2)|Prostate(94;0.183)				TTTGACAAAATACTGGGAGCG	0.383000													13	34					0	0	1	0	0
OR2L8	391190	broad.mit.edu	37	1	248112618	248112618	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr1:248112618C>G	ENST00000357191.3	+	1	459	c.459C>G	c.(457-459)atC>atG	p.I153M	OR2L13_ENST00000366478.2_Intron	NM_001001963.1	NP_001001963.1	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L, member 8 (gene/pseudogene)	153					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(30)|ovary(1)|prostate(1)|skin(3)	42	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			TAGGCTCGATCAATGCTTGTG	0.448000													23	168					0	0	1	0	0
SLC30A9	10463	broad.mit.edu	37	4	42037314	42037314	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr4:42037314A>G	ENST00000264451.7	+	7	813	c.633A>G	c.(631-633)atA>atG	p.I211M		NM_006345.3	NP_006336.3	Q6PML9	ZNT9_HUMAN	solute carrier family 30 (zinc transporter), member 9						nucleotide-excision repair|zinc ion transport	cytoskeleton|integral to membrane|nucleus	cation transmembrane transporter activity|nucleotide binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						ACCAAAAAATATTAAGAGAAT	0.303000													27	72					0	0	1	0	0
GRIP2	80852	broad.mit.edu	37	3	14552783	14552783	+	RNA	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr3:14552783G>C	ENST00000273083.3	-	0	1887							Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2						synaptic transmission	cytosol|plasma membrane	protein binding			endometrium(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	25						ATTGTCAATGGCCAGTAGCTT	0.617000													6	36					0	0	1	0	0
MYLIP	29116	broad.mit.edu	37	6	16141917	16141917	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:16141917G>C	ENST00000356840.3	+	3	538	c.340G>C	c.(340-342)Gag>Cag	p.E114Q	MYLIP_ENST00000349606.4_5'UTR	NM_013262.3	NP_037394.2	Q8WY64	MYLIP_HUMAN	myosin regulatory light chain interacting protein	114	FERM.				cellular component movement|nervous system development	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	28	Breast(50;0.0799)|Ovarian(93;0.103)	all_hematologic(90;0.0895)	Epithelial(50;0.241)			GTGTTCCCCAGAGCAGGCAGT	0.522000													12	35					0	0	1	0	0
RIMBP2	23504	broad.mit.edu	37	12	130892335	130892335	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr12:130892335G>C	ENST00000261655.4	-	16	3024	c.2861C>G	c.(2860-2862)aCg>aGg	p.T954R		NM_015347.4	NP_056162.4	O15034	RIMB2_HUMAN	RIMS binding protein 2	954	SH3 3.					cell junction|synapse				NS(2)|breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(33)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	96	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		CATTCTCCGCGTCGATACCGA	0.512000													17	188					0	0	1	0	0
DOPEY2	9980	broad.mit.edu	37	21	37602933	37602933	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr21:37602933G>A	ENST00000399151.3	+	14	1936	c.1851G>A	c.(1849-1851)tgG>tgA	p.W617*		NM_005128.2	NP_005119.2	Q9Y3R5	DOP2_HUMAN	dopey family member 2	617					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(6)|lung(25)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						ACGACGTTTGGAAGAAGGGCG	0.537000													16	76					0	0	1	0	0
GTF3C1	2975	broad.mit.edu	37	16	27518477	27518477	+	Splice_Site	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr16:27518477C>A	ENST00000356183.4	-	9	1258	c.1243G>T	c.(1243-1245)Gga>Tga	p.G415*	GTF3C1_ENST00000561623.1_Splice_Site_p.G415*	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	415						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						TCCATGAATCCCTAGAGGGAA	0.507000													11	95					0.010729	0.0113615	1	1	0
UNC13A	23025	broad.mit.edu	37	19	17752225	17752225	+	Silent	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr19:17752225G>A	ENST00000428389.2	-	22	2876	c.2877C>T	c.(2875-2877)gtC>gtT	p.V959V	UNC13A_ENST00000252773.7_Silent_p.V871V|UNC13A_ENST00000551649.1_Silent_p.V871V|UNC13A_ENST00000550896.1_Silent_p.V869V|UNC13A_ENST00000552293.1_Silent_p.V871V|UNC13A_ENST00000519716.2_Silent_p.V871V			Q9UPW8	UN13A_HUMAN	unc-13 homolog A (C. elegans)	871					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|prostate(2)	61						AGATGGACTCGACGCCGTAGC	0.582000													19	10					0	0	1	0	0
LRRC16A	55604	broad.mit.edu	37	6	25540227	25540227	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:25540227G>T	ENST00000329474.6	+	26	2617	c.2249G>T	c.(2248-2250)gGc>gTc	p.G750V		NM_001173977.1|NM_017640.5	NP_001167448.1|NP_060110.4	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	750					actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				breast(4)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	50						GGAGCCAGTGGCTTACTATCC	0.393000													5	30					0.000157383	0.000176284	1	1	0
HIVEP2	3097	broad.mit.edu	37	6	143095264	143095264	+	Silent	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:143095264C>G	ENST00000367603.2	-	5	1354	c.612G>C	c.(610-612)ctG>ctC	p.L204L	HIVEP2_ENST00000367604.1_Silent_p.L204L|HIVEP2_ENST00000012134.2_Silent_p.L204L	NM_006734.3	NP_006725.3	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer binding protein 2	204					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(4)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(19)|lung(35)|ovary(4)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	100				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		TGTGTTTTTTCAGTACACTAG	0.463000													25	95					0	0	1	0	0
LIPJ	142910	broad.mit.edu	37	10	90356565	90356565	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr10:90356565G>C	ENST00000371939.3	+	8	909	c.595G>C	c.(595-597)Gac>Cac	p.D199H		NM_001010939.2	NP_001010939.2	Q5W064	LIPJ_HUMAN	lipase, family member J	199					lipid catabolic process		hydrolase activity			large_intestine(4)|lung(4)|ovary(1)	9		all_cancers(4;2.79e-10)|Prostate(4;1.68e-15)|all_epithelial(4;1.43e-09)|Colorectal(252;0.0381)|Breast(4;0.141)|Melanoma(5;0.2)|all_hematologic(4;0.222)		Colorectal(12;1.02e-05)|COAD - Colon adenocarcinoma(12;1.54e-05)		AGGCAACAAAGACTTCTTGCC	0.303000													45	134					0	0	1	0	0
ZAP70	7535	broad.mit.edu	37	2	98350949	98350949	+	Translation_Start_Site	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr2:98350949C>A	ENST00000451498.2	+	0	81				ZAP70_ENST00000264972.5_Intron|ZAP70_ENST00000442208.1_Intron|ZAP70_ENST00000463643.1_Intron	NM_207519.1	NP_997402.1	P43403	ZAP70_HUMAN	zeta-chain (TCR) associated protein kinase 70kDa						immune response|intracellular protein kinase cascade|positive thymic T cell selection|T cell receptor signaling pathway	cytosol|T cell receptor complex	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	29						CACCCCTGCCCCTGACCTGGG	0.652000													6	8					0.00116845	0.00127062	1	1	0
IQGAP1	8826	broad.mit.edu	37	15	91017820	91017820	+	Silent	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr15:91017820G>T	ENST00000268182.5	+	23	2803	c.2679G>T	c.(2677-2679)cgG>cgT	p.R893R	IQGAP1_ENST00000560020.1_3'UTR|IQGAP1_ENST00000560738.1_Silent_p.R321R	NM_003870.3	NP_003861.1	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	893					energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			breast(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|liver(1)|lung(18)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			TGAAGATGCGGGAAGAGGTTA	0.448000													11	41					4.68919e-08	5.60162e-08	1	1	0
AMMECR1L	83607	broad.mit.edu	37	2	128622681	128622681	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr2:128622681T>C	ENST00000272647.5	-	8	1180	c.920A>G	c.(919-921)aAt>aGt	p.N307S	AMMECR1L_ENST00000393001.1_Missense_Mutation_p.N307S	NM_001199140.1	NP_001186069.1	Q6DCA0	AMERL_HUMAN	AMMECR1-like	307										central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)	9	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.07)		GGAGTAATGATTGTAGAGGGG	0.547000													25	39					0	0	1	0	0
TSPAN15	23555	broad.mit.edu	37	10	71264211	71264211	+	Silent	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr10:71264211C>T	ENST00000373290.2	+	6	710	c.588C>T	c.(586-588)acC>acT	p.T196T	TSPAN15_ENST00000459981.1_3'UTR	NM_012339.3	NP_036471.1	O95858	TSN15_HUMAN	tetraspanin 15	196						integral to plasma membrane|membrane fraction				breast(1)|endometrium(1)|large_intestine(1)|lung(4)|pancreas(1)|prostate(1)	9						TTGTCAACACCATGTGTGGCT	0.408000													19	77					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72827575	72827575	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr16:72827575C>G	ENST00000268489.5	-	9	9678	c.9006G>C	c.(9004-9006)aaG>aaC	p.K3002N	ZFHX3_ENST00000397992.5_Missense_Mutation_p.K2088N	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	3002					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				ACTTGGACTTCTTTTCTTTTG	0.483000													8	138					0	0	1	0	0
IFNGR1	3459	broad.mit.edu	37	6	137525483	137525483	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:137525483T>C	ENST00000367739.4	-	4	653	c.532A>G	c.(532-534)Atg>Gtg	p.M178V	IFNGR1_ENST00000543628.1_Missense_Mutation_p.M150V|IFNGR1_ENST00000367735.2_Missense_Mutation_p.M168V	NM_000416.2	NP_000407.1	P15260	INGR1_HUMAN	interferon gamma receptor 1	178					regulation of interferon-gamma-mediated signaling pathway|response to virus	integral to plasma membrane	interferon-gamma receptor activity			central_nervous_system(1)|kidney(3)|large_intestine(3)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	18	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000829)|OV - Ovarian serous cystadenocarcinoma(155;0.00389)	Interferon gamma-1b(DB00033)	CTTCCGTTCATTCTCACATAC	0.373000													33	58					0	0	1	0	0
NDUFA9	4704	broad.mit.edu	37	12	4768304	4768304	+	Silent	SNP	T	T	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr12:4768304T>C	ENST00000266544.5	+	5	533	c.513T>C	c.(511-513)aaT>aaC	p.N171N	RP11-500M8.7_ENST00000536588.1_3'UTR	NM_005002.4	NP_004993.1	Q16795	NDUA9_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa	171					mitochondrial electron transport, NADH to ubiquinone|sodium ion transport	mitochondrial matrix|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity|protein binding			NS(1)|breast(1)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	21					NADH(DB00157)	CACATCTGAATGCGAATATTA	0.368000													16	50					0	0	1	0	0
PIGV	55650	broad.mit.edu	37	1	27121583	27121583	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr1:27121583G>T	ENST00000374145.1	+	3	1740	c.1058G>T	c.(1057-1059)tGc>tTc	p.C353F	PIGV_ENST00000449950.2_Missense_Mutation_p.C125F|PIGV_ENST00000078527.4_Missense_Mutation_p.C353F	NM_001202554.1	NP_001189483.1	Q9NUD9	PIGV_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class V	353					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	glycolipid mannosyltransferase activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(2)	14		all_cancers(24;3.93e-26)|all_epithelial(13;3.96e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.26e-54)|Epithelial(14;2.85e-53)|OV - Ovarian serous cystadenocarcinoma(117;1.91e-30)|Colorectal(126;1.31e-09)|COAD - Colon adenocarcinoma(152;3.45e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000504)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.0222)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.153)|LUSC - Lung squamous cell carcinoma(448;0.227)		CCTTGGCTCTGCCTTACACTT	0.522000													6	82					0.00116845	0.00127062	1	1	0
PQLC2	54896	broad.mit.edu	37	1	19652799	19652799	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr1:19652799T>A	ENST00000375153.3	+	5	1083	c.443T>A	c.(442-444)cTg>cAg	p.L148Q	PQLC2_ENST00000400548.2_Missense_Mutation_p.L83Q|PQLC2_ENST00000375155.3_Missense_Mutation_p.L148Q	NM_001040125.1	NP_001035214.1	Q6ZP29	PQLC2_HUMAN	PQ loop repeat containing 2	148						integral to membrane				haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|skin(1)|urinary_tract(1)	10		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;1.89e-05)|Kidney(64;0.000177)|GBM - Glioblastoma multiforme(114;0.00124)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GCCACACCGCTGCTGAGTGCT	0.672000													9	35					0	0	1	0	0
CDH9	1007	broad.mit.edu	37	5	26906079	26906079	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr5:26906079C>T	ENST00000231021.4	-	5	972	c.800G>A	c.(799-801)cGa>cAa	p.R267Q		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	267	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.R267Q(1)		breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						CTGGGGAAATCGAGGAGGGTT	0.428000													4	137					0	0	1	0	0
CADPS	8618	broad.mit.edu	37	3	62478084	62478084	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr3:62478084G>T	ENST00000383710.4	-	20	3114	c.2765C>A	c.(2764-2766)gCg>gAg	p.A922E	CADPS_ENST00000357948.3_Missense_Mutation_p.A892E|CADPS_ENST00000283269.9_Missense_Mutation_p.A932E	NM_003716.3	NP_003707.2	Q9ULU8	CAPS1_HUMAN	Ca++-dependent secretion activator	922	Interaction with DRD2.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			breast(3)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(24)|lung(38)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(2)	92		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		GAACGTCTCCGCATGCTCCAC	0.448000													6	355					2.7689e-08	3.33229e-08	1	1	0
ATG2B	55102	broad.mit.edu	37	14	96771977	96771977	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr14:96771977C>G	ENST00000359933.4	-	31	5575	c.4682G>C	c.(4681-4683)gGa>gCa	p.G1561A	ATG2B_ENST00000261834.5_5'UTR	NM_018036.5	NP_060506	Q96BY7	ATG2B_HUMAN	autophagy related 2B	1561										breast(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(11)|liver(1)|lung(26)|ovary(1)|prostate(1)|skin(1)|urinary_tract(7)	64		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		ATCCTTTCCTCCATAAAGATG	0.408000													8	56					0	0	1	0	0
PUF60	22827	broad.mit.edu	37	8	144900436	144900436	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr8:144900436T>C	ENST00000526683.1	-	7	1085	c.530A>G	c.(529-531)tAt>tGt	p.Y177C	PUF60_ENST00000349157.6_Missense_Mutation_p.Y160C|PUF60_ENST00000524570.1_5'UTR|PUF60_ENST00000527197.1_Missense_Mutation_p.Y131C|PUF60_ENST00000456095.2_Missense_Mutation_p.Y148C|PUF60_ENST00000453551.2_Missense_Mutation_p.Y134C|PUF60_ENST00000313352.7_Missense_Mutation_p.Y117C	NM_001271098.1|NM_078480.2	NP_001258027.1|NP_510965.1	Q9UHX1	PUF60_HUMAN	poly-U binding splicing factor 60KDa	177	Inhibits homodimerization.|Inhibits transcriptional repression, interaction with ERCC3 and apoptosis induction.|RRM 1.				apoptosis|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nucleus|ribonucleoprotein complex	DNA binding|nucleotide binding|protein binding|RNA binding			NS(1)|endometrium(1)|kidney(3)|lung(7)|prostate(2)	14	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			GGGGACCTCATACTCCACGAA	0.652000													28	20					0	0	1	0	0
SLC30A6	55676	broad.mit.edu	37	2	32445633	32445633	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr2:32445633C>G	ENST00000282587.5	+	14	1274	c.1237C>G	c.(1237-1239)Ctc>Gtc	p.L413V	SLC30A6_ENST00000406369.1_Missense_Mutation_p.L339V|SLC30A6_ENST00000435660.1_Missense_Mutation_p.L390V|SLC30A6_ENST00000357055.3_Missense_Mutation_p.L216V|SLC30A6_ENST00000379343.2_Missense_Mutation_p.L453V|SLC30A6_ENST00000538303.1_Missense_Mutation_p.L384V	NM_017964.3	NP_060434.2	Q6NXT4	ZNT6_HUMAN	solute carrier family 30 (zinc transporter), member 6	413						Golgi membrane|integral to membrane	zinc ion transmembrane transporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(4)|lung(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					TGGTTTTGGTCTCAATCATGG	0.408000													27	90					0	0	1	0	0
XPO4	64328	broad.mit.edu	37	13	21370908	21370908	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr13:21370908C>A	ENST00000400602.2	-	17	2646	c.2611G>T	c.(2611-2613)Gga>Tga	p.G871*	XPO4_ENST00000255305.6_Nonsense_Mutation_p.G871*	NM_022459.4	NP_071904.4	Q9C0E2	XPO4_HUMAN	exportin 4	871					protein transport	cytoplasm|nucleus	protein binding			breast(1)|endometrium(10)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	41		all_cancers(29;5.05e-24)|all_epithelial(30;5.56e-20)|all_lung(29;2.38e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000521)|Epithelial(112;0.000892)|OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Lung(94;0.0189)|LUSC - Lung squamous cell carcinoma(192;0.0548)		CTTACCTCTCCAAGATAGCAT	0.313000													4	38					1.024e-07	1.21428e-07	1	1	0
NUP88	4927	broad.mit.edu	37	17	5289549	5289549	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr17:5289549T>C	ENST00000573584.1	-	17	2712	c.2203A>G	c.(2203-2205)Atc>Gtc	p.I735V		NM_002532.4	NP_002523.2	Q99567	NUP88_HUMAN	nucleoporin 88kDa	735					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	transporter activity	p.I735V(1)		endometrium(4)|kidney(4)|large_intestine(4)|lung(3)	15						TGATTGCGGATATCATTGATT	0.358000													73	6					0	0	1	0	0
STAP2	55620	broad.mit.edu	37	19	4327383	4327383	+	Splice_Site	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr19:4327383C>T	ENST00000600324.1	-	7	658		c.e7-1		STAP2_ENST00000597593.1_Splice_Site|STAP2_ENST00000594605.1_Splice_Site	NM_017720.2	NP_060190.2	Q9UGK3	STAP2_HUMAN	signal transducing adaptor family member 2							cytoplasm|nucleus	protein binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)	23		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0339)|STAD - Stomach adenocarcinoma(1328;0.18)		CACGTGCGTCCTGCACCAGGA	0.632000													10	15					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7582914	7582914	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:7582914C>G	ENST00000379802.3	+	24	5760	c.5419C>G	c.(5419-5421)Cag>Gag	p.Q1807E	DSP_ENST00000418664.2_Missense_Mutation_p.Q1208E	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	1807	Central fibrous rod domain.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TCAGTGTACTCAGGTGGTACA	0.403000													5	83					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178916957	178916957	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr3:178916957G>T	ENST00000263967.3	+	2	501	c.344G>T	c.(343-345)cGa>cTa	p.R115L		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	115					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.R115L(3)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			ATCCTCAATCGAGAAATTGGT	0.333000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			30	27					1.38854e-25	1.78632e-25	1	1	0
DPF1	8193	broad.mit.edu	37	19	38713043	38713043	+	Silent	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr19:38713043G>C	ENST00000416611.1	-	3	378	c.255C>G	c.(253-255)ctC>ctG	p.L85L	DPF1_ENST00000420980.2_Silent_p.L111L|DPF1_ENST00000355526.4_Silent_p.L111L|DPF1_ENST00000456296.1_Silent_p.L85L|DPF1_ENST00000412732.1_Silent_p.L29L|DPF1_ENST00000414789.1_Silent_p.L29L			Q92782	DPF1_HUMAN	D4, zinc and double PHD fingers family 1	111					induction of apoptosis|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nBAF complex	zinc ion binding			large_intestine(1)|lung(4)|ovary(1)|skin(1)	7	all_cancers(60;1.24e-06)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CCAGGATGTTGAGTCTCCGTT	0.662000													33	131					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77748454	77748454	+	Silent	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr13:77748454G>C	ENST00000407578.2	-	37	5909	c.5643C>G	c.(5641-5643)ctC>ctG	p.L1881L	MYCBP2_ENST00000544440.2_Silent_p.L1843L|MYCBP2_ENST00000360084.5_5'UTR|MYCBP2_ENST00000357337.6_Silent_p.L1843L	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	1843			A -> S (in dbSNP:rs35887505).		regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		ACCTATAGTAGAGTATCTGTG	0.433000													15	42					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38168748	38168748	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr22:38168748G>A	ENST00000406386.3	+	23	7332	c.7077G>A	c.(7075-7077)atG>atA	p.M2359I	TRIOBP_ENST00000403663.2_Missense_Mutation_p.M646I	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	2359				M -> I (in Ref. 1; AAG44841).	actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					AGGAGTCGATGCGCAACAGCC	0.657000													4	144					0	0	1	0	0
FBXO44	93611	broad.mit.edu	37	1	11716154	11716154	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr1:11716154G>T	ENST00000376770.1	+	3	760	c.262G>T	c.(262-264)Gaa>Taa	p.E88*	FBXO44_ENST00000251547.5_Nonsense_Mutation_p.E88*|FBXO44_ENST00000376768.1_Nonsense_Mutation_p.E88*|FBXO44_ENST00000251546.4_Nonsense_Mutation_p.E88*|FBXO44_ENST00000376760.1_Nonsense_Mutation_p.E88*|FBXO44_ENST00000376762.4_Nonsense_Mutation_p.E88*	NM_001014765.1	NP_001014765.1	Q9H4M3	FBX44_HUMAN	F-box protein 44	88	FBA.				protein catabolic process	SCF ubiquitin ligase complex	protein binding			kidney(1)|large_intestine(1)|lung(3)|ovary(1)|pancreas(1)|prostate(1)	8	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.41e-06)|COAD - Colon adenocarcinoma(227;0.000255)|BRCA - Breast invasive adenocarcinoma(304;0.0003)|Kidney(185;0.000758)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0649)		CCCGTGCGCTGAAGGTGGGGT	0.567000													4	81					0.000602214	0.000665317	1	1	0
PAICS	10606	broad.mit.edu	37	4	57314685	57314685	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr4:57314685G>C	ENST00000514888.1	+	5	734	c.219G>C	c.(217-219)atG>atC	p.M73I	PAICS_ENST00000512576.1_Missense_Mutation_p.M165I|PAICS_ENST00000264221.2_Missense_Mutation_p.M165I|PAICS_ENST00000399688.3_Missense_Mutation_p.M172I			P22234	PUR6_HUMAN	phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase	165	SAICAR synthetase.				'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|identical protein binding|phosphoribosylaminoimidazole carboxylase activity|phosphoribosylaminoimidazolesuccinocarboxamide synthase activity			endometrium(1)|kidney(2)|large_intestine(1)|urinary_tract(1)	5	Glioma(25;0.08)|all_neural(26;0.101)				L-Aspartic Acid(DB00128)	TGGATATCATGAGTCATGCTA	0.413000													4	10					0	0	1	0	0
ICAM2	3384	broad.mit.edu	37	17	62080230	62080230	+	Silent	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr17:62080230C>T	ENST00000412356.1	-	6	1059	c.705G>A	c.(703-705)ctG>ctA	p.L235L	ICAM2_ENST00000449662.2_Silent_p.L235L|ICAM2_ENST00000581417.1_5'UTR|ICAM2_ENST00000578892.1_Silent_p.L211L|C17orf72_ENST00000412177.1_3'UTR|ICAM2_ENST00000578379.1_Silent_p.L134L|ICAM2_ENST00000579687.1_Silent_p.L235L|ICAM2_ENST00000579788.1_Silent_p.L235L|ICAM2_ENST00000418105.1_Silent_p.L235L	NM_001099786.1	NP_001093256.1	P13598	ICAM2_HUMAN	intercellular adhesion molecule 2	235					cell-cell adhesion|regulation of immune response	integral to plasma membrane	integrin binding			large_intestine(1)|lung(2)|ovary(1)|skin(2)	6						CGAACAGGGACAGCAACACCG	0.622000													3	27					0	0	1	0	0
IL3RA	3563	broad.mit.edu	37	X	1484088	1484088	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chrX:1484088A>G	ENST00000331035.4	+	9	1166	c.817A>G	c.(817-819)Aga>Gga	p.R273G	IL3RA_ENST00000381469.2_Missense_Mutation_p.R195G	NM_001267713.1|NM_002183.3	NP_001254642.1|NP_002174.1	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha (low affinity)	273						integral to membrane|plasma membrane	interleukin-3 receptor activity			lung(1)|skin(2)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	AGTACAAATAAGAGCCCGGGA	0.562000													29	48					0	0	1	0	0
PNLIPRP1	5407	broad.mit.edu	37	10	118364952	118364952	+	Silent	SNP	T	T	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr10:118364952T>C	ENST00000528052.1	+	12	1298	c.1227T>C	c.(1225-1227)gaT>gaC	p.D409D	PNLIPRP1_ENST00000358834.4_Silent_p.D409D|PNLIPRP1_ENST00000534537.1_Silent_p.D409D			P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1	409	PLAT.				lipid metabolic process		calcium ion binding|triglyceride lipase activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	38				all cancers(201;0.0161)		CAAAGCTGGATGTTGGAACAA	0.428000													25	98					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152080573	152080573	+	Missense_Mutation	SNP	C	C	T	rs71585886		TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr1:152080573C>T	ENST00000368804.1	-	2	5119	c.5120G>A	c.(5119-5121)aGa>aAa	p.R1707K		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	1707	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGGAATTTTCTCTCTCGTTC	0.587000													36	67					0	0	1	0	0
DICER1	23405	broad.mit.edu	37	14	95560417	95560417	+	Silent	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr14:95560417C>T	ENST00000526495.1	-	26	5463	c.5172G>A	c.(5170-5172)ccG>ccA	p.P1724P	DICER1_ENST00000393063.1_Silent_p.P1724P|DICER1_ENST00000527414.1_Silent_p.P1724P|DICER1_ENST00000556045.1_Silent_p.P622P|DICER1_ENST00000541352.1_Silent_p.P1724P|DICER1_ENST00000343455.3_Silent_p.P1724P			Q9UPY3	DICER_HUMAN	dicer 1, ribonuclease type III	1724	RNase III 2.				negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(13)|kidney(3)|large_intestine(10)|lung(33)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)	75		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		AGTGCTGCCGCGGGTCTTCAT	0.537000			"""Mis F, N"""		"""sex cord-stromal tumour, TGCT, embryonal rhadomyosarcoma"""	pleuropulmonary blastoma			Familial Multinodular Goiter ;DICER 1 syndrome				6	67					0	0	1	0	0
WAS	7454	broad.mit.edu	37	X	48547059	48547059	+	Silent	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chrX:48547059G>A	ENST00000376701.4	+	10	1017	c.942G>A	c.(940-942)ccG>ccA	p.P314P		NM_000377.2	NP_000368.1	P42768	WASP_HUMAN	Wiskott-Aldrich syndrome	314	Poly-Pro.				blood coagulation|defense response|epidermis development|immune response|T cell receptor signaling pathway	actin cytoskeleton|cytosol	identical protein binding|small GTPase regulator activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)	28		all_lung(315;1.27e-10)				AGCCACTTCCGCCGCCCCCAC	0.567000			"""Mis, N, F, S"""			lymphoma							18	2					0	0	1	0	0
ADRBK1	156	broad.mit.edu	37	11	67047367	67047367	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr11:67047367G>A	ENST00000308595.5	+	6	789	c.499G>A	c.(499-501)Gag>Aag	p.E167K	ADRBK1_ENST00000526285.1_Missense_Mutation_p.E167K	NM_001619.3	NP_001610.2	P25098	ARBK1_HUMAN	adrenergic, beta, receptor kinase 1	167	N-terminal.|RGS.				activation of phospholipase C activity|cardiac muscle contraction|desensitization of G-protein coupled receptor protein signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of striated muscle contraction|negative regulation of the force of heart contraction by chemical signal|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of catecholamine secretion|tachykinin receptor signaling pathway	cytosol|soluble fraction	alpha-2A adrenergic receptor binding|ATP binding|beta-adrenergic receptor kinase activity|Edg-2 lysophosphatidic acid receptor binding|G-protein coupled receptor kinase activity|signal transducer activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|liver(2)|lung(8)|prostate(2)	22			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)		Adenosine triphosphate(DB00171)	GAAATTCATTGAGAGGTGAGA	0.567000													13	44					0	0	1	0	0
PCDHA7	56141	broad.mit.edu	37	5	140215430	140215430	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr5:140215430G>T	ENST00000525929.1	+	1	1462	c.1462G>T	c.(1462-1464)Gcg>Tcg	p.A488S	PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA7_ENST00000378125.3_Missense_Mutation_p.A488S|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron	NM_018910.2	NP_061733.1														NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAGAAGAACGCGCTGGTGTC	0.667000													4	63					0.184627	0.186551	1	1	0
SMYD1	150572	broad.mit.edu	37	2	88409913	88409913	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr2:88409913G>T	ENST00000419482.2	+	10	1440	c.1355G>T	c.(1354-1356)cGc>cTc	p.R452L	SMYD1_ENST00000444564.2_Missense_Mutation_p.R439L|SMYD1_ENST00000438570.1_Intron	NM_198274.3	NP_938015.1	Q8NB12	SMYD1_HUMAN	SET and MYND domain containing 1	452					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	41						CGCATGTTCCGCCAGAACGAA	0.572000													3	23					0.00909568	0.00967413	1	1	0
AZI2	64343	broad.mit.edu	37	3	28380066	28380066	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr3:28380066C>G	ENST00000479665.1	-	3	788	c.257G>C	c.(256-258)cGa>cCa	p.R86P	AZI2_ENST00000420543.2_Missense_Mutation_p.R86P|AZI2_ENST00000457172.1_Missense_Mutation_p.R86P|AZI2_ENST00000295748.3_5'UTR|AZI2_ENST00000334100.6_Missense_Mutation_p.R86P	NM_022461.3	NP_071906.1	Q9H6S1	AZI2_HUMAN	5-azacytidine induced 2	86						mitochondrion|plasma membrane				cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	15						TACTTGTTCTCGTCCCACGGA	0.348000													3	71					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104152923	104152923	+	Silent	SNP	C	C	A	rs112523896		TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr12:104152923C>A	ENST00000388887.2	+	65	7324	c.7120C>A	c.(7120-7122)Cgg>Agg	p.R2374R	RP11-341G23.4_ENST00000551299.1_RNA	NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	2374	FAS1 7.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						CTTGTCTGGGCGGGACATCGA	0.463000													25	104					1.77063e-15	2.21901e-15	1	1	0
NDUFB10	4716	broad.mit.edu	37	16	2011547	2011547	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr16:2011547T>C	ENST00000543683.2	+	3	401	c.319T>C	c.(319-321)Tgt>Cgt	p.C107R	NDUFB10_ENST00000268668.6_Missense_Mutation_p.C107R|NDUFB10_ENST00000569148.1_Missense_Mutation_p.C96R			O96000	NDUBA_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa	107					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity|protein binding			lung(1)|urinary_tract(1)	2					NADH(DB00157)	GCTCAAAGCCTGTCAGCAGAG	0.517000													62	51					0	0	1	0	0
HACL1	26061	broad.mit.edu	37	3	15616524	15616524	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr3:15616524C>G	ENST00000321169.5	-	10	1236	c.869G>C	c.(868-870)gGa>gCa	p.G290A	HACL1_ENST00000435217.2_Intron|HACL1_ENST00000456194.2_Missense_Mutation_p.G263A|HACL1_ENST00000451445.2_Missense_Mutation_p.G208A|HACL1_ENST00000457447.2_Missense_Mutation_p.G264A	NM_012260.2	NP_036392.2	Q9UJ83	HACL1_HUMAN	2-hydroxyacyl-CoA lyase 1	290					fatty acid alpha-oxidation	peroxisomal matrix	carbon-carbon lyase activity|identical protein binding|magnesium ion binding|thiamine pyrophosphate binding			NS(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|skin(1)	16						TGGAGGCAGTCCAAAATGTAA	0.338000													9	54					0	0	1	0	0
MDC1	9656	broad.mit.edu	37	6	30673532	30673532	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:30673532G>C	ENST00000376406.3	-	10	4075	c.3428C>G	c.(3427-3429)tCt>tGt	p.S1143C	MDC1-AS1_ENST00000442150.1_RNA|MDC1_ENST00000376405.2_Missense_Mutation_p.S879C	NM_014641.2	NP_055456.2	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1143	Pro-rich.			Missing (in Ref. 2; CAH18685).	cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|kidney(1)|ovary(1)	4						AGTGGCCTGAGATGTGGGCTT	0.607000								Other conserved DNA damage response genes					5	180					0	0	1	0	0
PMFBP1	83449	broad.mit.edu	37	16	72188328	72188328	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr16:72188328C>T	ENST00000537465.1	-	4	354	c.196G>A	c.(196-198)Gag>Aag	p.E66K	PMFBP1_ENST00000237353.10_Missense_Mutation_p.E66K|PMFBP1_ENST00000543746.1_5'UTR|PMFBP1_ENST00000355636.6_5'UTR			Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	66										NS(1)|breast(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	45		Ovarian(137;0.179)				TCTGACTCCTCGAATGCTAAT	0.418000													5	90					0	0	1	0	0
CREBBP	1387	broad.mit.edu	37	16	3777906	3777906	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr16:3777906C>A	ENST00000262367.5	-	31	7951	c.7142G>T	c.(7141-7143)gGt>gTt	p.G2381V	CREBBP_ENST00000382070.3_Missense_Mutation_p.G2343V	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	2381					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		GTGGGGGGAACCAGTCTGGGG	0.642000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						21	54					8.04996e-18	1.01673e-17	1	1	0
KLHDC10	23008	broad.mit.edu	37	7	129756427	129756427	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr7:129756427G>A	ENST00000335420.5	+	3	530	c.396G>A	c.(394-396)tgG>tgA	p.W132*	KLHDC10_ENST00000495724.1_3'UTR	NM_014997.3	NP_055812.1	Q6PID8	KLD10_HUMAN	kelch domain containing 10	132										breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|liver(2)|lung(10)|prostate(1)	17						GGGAACTCTGGAGGTATCATT	0.463000													12	42					0	0	1	0	0
S1PR4	8698	broad.mit.edu	37	19	3179874	3179874	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr19:3179874C>T	ENST00000246115.3	+	1	1139	c.1084C>T	c.(1084-1086)Cgc>Tgc	p.R362C		NM_003775.3	NP_003766.1	O95977	S1PR4_HUMAN	sphingosine-1-phosphate receptor 4	362					activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			breast(1)|kidney(2)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	13						GGACAGCTTTCGCGGCTCCCG	0.672000													34	60					0	0	1	0	0
MYH14	79784	broad.mit.edu	37	19	50784954	50784954	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr19:50784954G>T	ENST00000440075.2	+	33	4441	c.4394G>T	c.(4393-4395)cGc>cTc	p.R1465L	MYH14_ENST00000425460.1_Missense_Mutation_p.R1432L|MYH14_ENST00000601313.1_Missense_Mutation_p.R1465L|MYH14_ENST00000376970.2_Missense_Mutation_p.R1457L|MYH14_ENST00000262269.8_Missense_Mutation_p.R1465L|MYH14_ENST00000598205.1_Missense_Mutation_p.R1432L|MYH14_ENST00000596571.1_Missense_Mutation_p.R1424L			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	1424					axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		CTGACCCAGCGCCTGGCAGAA	0.746000													9	23					5.4927e-09	6.62677e-09	1	1	0
STAC3	246329	broad.mit.edu	37	12	57637690	57637690	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr12:57637690C>T	ENST00000332782.2	-	12	1201	c.1000G>A	c.(1000-1002)Gtg>Atg	p.V334M	STAC3_ENST00000546246.2_Missense_Mutation_p.V148M|STAC3_ENST00000554578.1_Missense_Mutation_p.V295M	NM_145064.1	NP_659501.1	Q96MF2	STAC3_HUMAN	SH3 and cysteine rich domain 3	334	SH3 2.				intracellular signal transduction		identical protein binding|metal ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(10)|ovary(2)|skin(1)	18						TTCTGCACCACGATCTAGAAG	0.542000											OREG0021942	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	23					0	0	1	0	0
PRTG	283659	broad.mit.edu	37	15	55965712	55965712	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr15:55965712G>A	ENST00000389286.4	-	10	1756	c.1709C>T	c.(1708-1710)cCg>cTg	p.P570L		NM_173814.4	NP_776175.2	Q2VWP7	PRTG_HUMAN	protogenin	570	Fibronectin type-III 2.				multicellular organismal development	integral to membrane				breast(1)|endometrium(6)|kidney(4)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	41				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		CGTGGTCCCCGGGAGCTCCAG	0.547000													18	53					0	0	1	0	0
GABRA6	2559	broad.mit.edu	37	5	161115979	161115979	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr5:161115979C>T	ENST00000274545.5	+	4	683	c.250C>T	c.(250-252)Cgc>Tgc	p.R84C	GABRA6_ENST00000522269.1_3'UTR|RP11-348M17.2_ENST00000521984.1_RNA|GABRA6_ENST00000523217.1_Intron			Q16445	GBRA6_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 6	84					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(9)|liver(2)|lung(22)|ovary(7)|skin(6)|urinary_tract(2)	57	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TGTTTTTTTCCGCCAGACCTG	0.408000										TCGA Ovarian(5;0.080)			4	77					0	0	1	0	0
JAG2	3714	broad.mit.edu	37	14	105622234	105622234	+	Silent	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr14:105622234G>A	ENST00000331782.3	-	4	971	c.568C>T	c.(568-570)Ctg>Ttg	p.L190L	JAG2_ENST00000347004.2_Silent_p.L190L|RP11-44N21.4_ENST00000548203.1_RNA	NM_002226.4	NP_002217.3	Q9Y219	JAG2_HUMAN	jagged 2	190					auditory receptor cell fate commitment|cell communication|cell cycle|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation|spermatogenesis|thymic T cell selection	integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(1)|lung(7)|prostate(2)|skin(5)	22		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		TGCAGCTCCAGGTGCGCCACG	0.627000													4	12					0	0	1	0	0
PTK2	5747	broad.mit.edu	37	8	141889682	141889682	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr8:141889682C>A	ENST00000522684.1	-	4	479	c.250G>T	c.(250-252)Gga>Tga	p.G84*	PTK2_ENST00000535192.1_Nonsense_Mutation_p.G84*|PTK2_ENST00000521059.1_Nonsense_Mutation_p.G84*|PTK2_ENST00000519881.1_Nonsense_Mutation_p.G84*|PTK2_ENST00000340930.3_Nonsense_Mutation_p.G84*|PTK2_ENST00000395218.2_Nonsense_Mutation_p.G84*|PTK2_ENST00000517887.1_Nonsense_Mutation_p.G128*|PTK2_ENST00000520892.1_Nonsense_Mutation_p.G84*|PTK2_ENST00000519419.1_Nonsense_Mutation_p.G128*	NM_153831.3	NP_722560.1	Q05397	FAK1_HUMAN	protein tyrosine kinase 2	84	FERM.				axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(6)|lung(23)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	48	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)			AGGCGGAATCCATAGCAGGCC	0.488000													5	218					3.59834e-05	4.10634e-05	1	1	0
PRLHR	2834	broad.mit.edu	37	10	120354417	120354417	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr10:120354417C>A	ENST00000239032.2	-	2	478	c.340G>T	c.(340-342)Gtg>Ttg	p.V114L	PRLHR_ENST00000369169.1_Missense_Mutation_p.V114L	NM_004248.2	NP_004239	P49683	PRLHR_HUMAN	prolactin releasing hormone receptor	114					female pregnancy	integral to plasma membrane	neuropeptide Y receptor activity			large_intestine(2)|lung(8)|ovary(1)|skin(1)	12		Colorectal(252;0.0429)|Lung NSC(174;0.142)|all_lung(145;0.175)		all cancers(201;0.0166)		GTGAGCGGCACGCAGGCGGTG	0.667000													3	38					0.004672	0.00502421	1	1	0
HIST1H1C	3006	broad.mit.edu	37	6	26056117	26056117	+	Silent	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:26056117C>G	ENST00000343677.2	-	1	582	c.540G>C	c.(538-540)gcG>gcC	p.A180A		NM_005319.3	NP_005310.1	P16403	H12_HUMAN	histone cluster 1, H1c	180					nucleosome assembly	nucleosome|nucleus	DNA binding	p.A180A(2)		NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(1)|large_intestine(1)|lung(8)|ovary(4)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)	34						TCTTGGGCTTCGCAACCTTGG	0.542000													76	70					0	0	1	0	0
FUBP3	8939	broad.mit.edu	37	9	133506028	133506028	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr9:133506028C>G	ENST00000319725.9	+	13	1206	c.1131C>G	c.(1129-1131)atC>atG	p.I377M		NM_003934.1	NP_003925.1	Q96I24	FUBP3_HUMAN	far upstream element (FUSE) binding protein 3	377	KH 4.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|RNA binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(10)|ovary(2)|urinary_tract(2)	21				OV - Ovarian serous cystadenocarcinoma(145;0.000279)		GTGAGAACATCAAAAGCATCA	0.592000													15	32					0	0	1	0	0
ZNF518B	85460	broad.mit.edu	37	4	10447196	10447196	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr4:10447196G>C	ENST00000326756.3	-	3	1195	c.757C>G	c.(757-759)Caa>Gaa	p.Q253E		NM_053042.2	NP_444270.2	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	253					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(16)|ovary(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	42						CACTTATTTTGAAATGTAGTC	0.413000													31	146					0	0	1	0	0
PRAMEF2	65122	broad.mit.edu	37	1	12919825	12919825	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr1:12919825C>G	ENST00000240189.2	+	3	652	c.565C>G	c.(565-567)Cta>Gta	p.L189V		NM_023014.1	NP_075390.1	O60811	PRAM2_HUMAN	PRAME family member 2	189										breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(22)|prostate(6)|skin(3)|upper_aerodigestive_tract(4)	42	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GGTCAATTATCTAACGCCAAT	0.403000													86	400					0	0	1	0	0
ALAD	210	broad.mit.edu	37	9	116153854	116153854	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr9:116153854C>G	ENST00000409155.3	-	4	410	c.214G>C	c.(214-216)Ggc>Cgc	p.G72R	ALAD_ENST00000482001.1_5'UTR|ALAD_ENST00000277315.5_Missense_Mutation_p.G55R	NM_000031.5	NP_000022.3	P13716	HEM2_HUMAN	aminolevulinate dehydratase	72					heme biosynthetic process|protein homooligomerization	cytosol	identical protein binding|lead ion binding|porphobilinogen synthase activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)|stomach(1)	9					Aminolevulinic acid(DB00855)	CAGCGTAGGCCCTCTTCCACC	0.577000													5	53					0	0	1	0	0
GTF3C3	9330	broad.mit.edu	37	2	197662607	197662607	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr2:197662607G>C	ENST00000263956.3	-	2	217	c.128C>G	c.(127-129)tCa>tGa	p.S43*	GTF3C3_ENST00000409364.3_Nonsense_Mutation_p.S43*	NM_012086.4	NP_036218.1	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide 3, 102kDa	43						transcription factor TFIIIC complex	DNA binding|protein binding			breast(4)|endometrium(3)|kidney(1)|large_intestine(9)|lung(5)|ovary(3)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						TTCTTCAGCTGATAACTTGCC	0.368000													18	80					0	0	1	0	0
CNKSR3	154043	broad.mit.edu	37	6	154744114	154744114	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:154744114G>C	ENST00000607772.1	-	8	1277	c.733C>G	c.(733-735)Cct>Gct	p.P245A	CNKSR3_ENST00000433165.2_Missense_Mutation_p.P70A|CNKSR3_ENST00000479339.1_Missense_Mutation_p.P165A	NM_173515.2	NP_775786.2	Q6P9H4	CNKR3_HUMAN	CNKSR family member 3	245	PDZ.				negative regulation of ERK1 and ERK2 cascade|negative regulation of peptidyl-serine phosphorylation|positive regulation of sodium ion transport	cytoplasm|membrane				breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	15		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;5.03e-11)|BRCA - Breast invasive adenocarcinoma(81;0.00627)		CTGTCTGCAGGAGACTGTACA	0.358000													8	23					0	0	1	0	0
ARIH2	10425	broad.mit.edu	37	3	48965041	48965041	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr3:48965041A>G	ENST00000356401.4	+	3	389	c.50A>G	c.(49-51)tAt>tGt	p.Y17C	ARIH2_ENST00000449376.1_Missense_Mutation_p.Y17C|ARIH2_ENST00000490095.1_Intron	NM_006321.2	NP_006312.1	O95376	ARI2_HUMAN	ariadne RBR E3 ubiquitin protein ligase 2	17	Asp/Glu-rich (acidic).				developmental cell growth|hemopoietic stem cell proliferation|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)	13				BRCA - Breast invasive adenocarcinoma(193;9.42e-05)|Kidney(197;0.00258)|KIRC - Kidney renal clear cell carcinoma(197;0.00269)		GAAGAGGACTATGACCCAAAT	0.507000													9	10					0	0	1	0	0
PAPLN	89932	broad.mit.edu	37	14	73718407	73718407	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr14:73718407G>T	ENST00000427855.1	+	9	808	c.706G>T	c.(706-708)Ggg>Tgg	p.G236W	PAPLN_ENST00000555445.1_Missense_Mutation_p.G236W|PAPLN_ENST00000381166.3_Missense_Mutation_p.G236W|PAPLN_ENST00000340738.5_Missense_Mutation_p.G209W|PAPLN_ENST00000554301.1_Missense_Mutation_p.G236W			O95428	PPN_HUMAN	papilin, proteoglycan-like sulfated glycoprotein	236						proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(3)|pancreas(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(3)	42				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.0468)		CTACCTCAATGGGCACTGGAC	0.662000													4	107					0.00909568	0.00967413	1	1	0
CTRL	1506	broad.mit.edu	37	16	67964372	67964372	+	Missense_Mutation	SNP	G	G	T	rs148841919		TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr16:67964372G>T	ENST00000574481.1	-	5	999	c.438C>A	c.(436-438)aaC>aaA	p.N146K		NM_001907.2	NP_001898.1	P40313	CTRL_HUMAN	chymotrypsin-like	146	Peptidase S1.				digestion|proteolysis	extracellular space	serine-type endopeptidase activity			kidney(1)|large_intestine(2)|urinary_tract(1)	4		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00412)|Epithelial(162;0.018)|all cancers(182;0.118)		TCAGAGCCTCGTTTGAGGATG	0.612000													6	74					0.0293803	0.030644	1	1	0
KIAA1432	57589	broad.mit.edu	37	9	5763392	5763392	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr9:5763392C>G	ENST00000414202.2	+	19	2556	c.2365C>G	c.(2365-2367)Ctt>Gtt	p.L789V	KIAA1432_ENST00000449720.2_Missense_Mutation_p.L673V|KIAA1432_ENST00000251879.6_Missense_Mutation_p.L789V|KIAA1432_ENST00000418622.3_Missense_Mutation_p.L710V|KIAA1432_ENST00000381532.2_Missense_Mutation_p.L710V	NM_001206557.1|NM_020829.3	NP_001193486.1|NP_065880.2	Q4ADV7	RIC1_HUMAN	KIAA1432	789						integral to membrane				breast(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(6)|lung(23)|prostate(1)|upper_aerodigestive_tract(1)	45		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		TGCTTTAGTCCTTGGTGCTGT	0.473000													38	125					0	0	1	0	0
AARS2	57505	broad.mit.edu	37	6	44280986	44280986	+	Silent	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:44280986G>C	ENST00000244571.4	-	1	77	c.75C>G	c.(73-75)ctC>ctG	p.L25L	RP11-444E17.6_ENST00000505802.1_Intron	NM_020745.3	NP_065796	Q5JTZ9	SYAM_HUMAN	alanyl-tRNA synthetase 2, mitochondrial	25					alanyl-tRNA aminoacylation	mitochondrion	alanine-tRNA ligase activity|ATP binding|metal ion binding|tRNA binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(3)|skin(2)|stomach(1)	34	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)		L-Alanine(DB00160)	GCCGATGGCTGAGGCCCCGCC	0.692000											OREG0017474	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	7					0	0	1	0	0
RFX2	5990	broad.mit.edu	37	19	6040227	6040227	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr19:6040227C>T	ENST00000303657.5	-	5	435	c.286G>A	c.(286-288)Gag>Aag	p.E96K	RFX2_ENST00000359161.3_Missense_Mutation_p.E96K|RFX2_ENST00000592546.1_Missense_Mutation_p.E96K	NM_000635.3	NP_000626.2	P48378	RFX2_HUMAN	regulatory factor X, 2 (influences HLA class II expression)	96					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(4)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21						ATCTGAGGCTCGGGGTTGTAG	0.597000													27	84					0	0	1	0	0
SMC4	10051	broad.mit.edu	37	3	160122125	160122125	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr3:160122125G>A	ENST00000357388.3	+	5	971	c.520G>A	c.(520-522)Gat>Aat	p.D174N	SMC4_ENST00000344722.5_Missense_Mutation_p.D174N|SMC4_ENST00000360111.2_Missense_Mutation_p.D174N|RP11-432B6.3_ENST00000483754.1_Intron|SMC4_ENST00000470240.1_3'UTR|SMC4_ENST00000462787.1_Missense_Mutation_p.D174N|SMC4_ENST00000469762.1_Missense_Mutation_p.D149N	NM_001002800.1	NP_001002800.1	Q9NTJ3	SMC4_HUMAN	structural maintenance of chromosomes 4	174					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(15)|lung(20)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	48			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			GGAAGGGGATGATTATGAAGT	0.333000													9	41					0	0	1	0	0
MIR99AHG	388815	broad.mit.edu	37	21	17962584	17962584	+	RNA	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr21:17962584C>A	ENST00000458468.1	+	0	579				MIR125B2_ENST00000385128.1_RNA	NR_027790.1																						CCCTGAGACCCTAACTTGTGA	0.433000													10	82					0.0135373	0.0143041	1	1	0
PPP1CA	5499	broad.mit.edu	37	11	67168659	67168659	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr11:67168659G>A	ENST00000376745.4	-	2	215	c.67C>T	c.(67-69)Cgg>Tgg	p.R23W	PPP1CA_ENST00000312989.7_Missense_Mutation_p.R34W|PPP1CA_ENST00000532446.1_5'UTR|PPP1CA_ENST00000358239.4_Intron	NM_001008709.1|NM_002708.3	NP_001008709.1|NP_002699.1	P62136	PP1A_HUMAN	protein phosphatase 1, catalytic subunit, alpha isozyme	23					cell cycle|cell division|glycogen metabolic process|protein dephosphorylation|triglyceride catabolic process	cytosol|MLL5-L complex|nucleolus|PTW/PP1 phosphatase complex	metal ion binding|protein binding|protein phosphatase type 1 regulator activity|protein serine/threonine phosphatase activity			breast(1)|lung(2)|pancreas(1)|urinary_tract(3)	7			BRCA - Breast invasive adenocarcinoma(15;8.53e-07)			TTGCCAGGCCGCGAGCCCTGC	0.637000													18	59					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228504576	228504576	+	Silent	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr1:228504576C>T	ENST00000570156.2	+	62	16397	c.16323C>T	c.(16321-16323)gcC>gcT	p.A5441A	OBSCN_ENST00000422127.1_Silent_p.A4484A|OBSCN_ENST00000284548.11_Silent_p.A4484A|OBSCN_ENST00000366709.4_Silent_p.A1603A|OBSCN_ENST00000366707.4_Silent_p.A2118A	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	4484	Ig-like 51.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CTGTCACCGCCGACGGCAGTC	0.706000													5	4					0	0	1	0	0
HNF4A	3172	broad.mit.edu	37	20	43034848	43034848	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr20:43034848G>A	ENST00000316099.4	+	2	355	c.266G>A	c.(265-267)cGg>cAg	p.R89Q	HNF4A_ENST00000457232.1_Missense_Mutation_p.R67Q|HNF4A_ENST00000609795.1_Missense_Mutation_p.R67Q|HNF4A_ENST00000415691.2_Missense_Mutation_p.R89Q|HNF4A_ENST00000316673.4_Missense_Mutation_p.R67Q|HNF4A_ENST00000443598.2_Missense_Mutation_p.R89Q	NM_000457.4|NM_001258355.1|NM_178849.2	NP_000448.3|NP_001245284.1|NP_849180.1	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4, alpha						blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(4)|large_intestine(7)|lung(17)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(2)	34		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			AGGAGCGTGCGGAAGAACCAC	0.612000													5	25					0	0	1	0	0
ZNF660	285349	broad.mit.edu	37	3	44636137	44636137	+	Nonsense_Mutation	SNP	C	C	G	rs149936636		TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr3:44636137C>G	ENST00000322734.2	+	3	785	c.452C>G	c.(451-453)tCa>tGa	p.S151*	RP11-944L7.4_ENST00000457331.1_RNA	NM_173658.2	NP_775929.2	Q6AZW8	ZN660_HUMAN	zinc finger protein 660	151					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(2)|lung(4)	6				KIRC - Kidney renal clear cell carcinoma(197;0.0468)|Kidney(197;0.0585)		GGCCTTATATCACATCACAGA	0.458000													14	66					0	0	1	0	0
EDNRA	1909	broad.mit.edu	37	4	148461017	148461017	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr4:148461017C>G	ENST00000324300.5	+	6	1464	c.949C>G	c.(949-951)Ctt>Gtt	p.L317V	EDNRA_ENST00000511804.1_Missense_Mutation_p.L92V|EDNRA_ENST00000503721.1_3'UTR|EDNRA_ENST00000339690.5_3'UTR|EDNRA_ENST00000506066.1_Missense_Mutation_p.L208V|EDNRA_ENST00000358556.4_Missense_Mutation_p.L208V	NM_001957.3	NP_001948.1	P25101	EDNRA_HUMAN	endothelin receptor type A	317					activation of adenylate cyclase activity|artery smooth muscle contraction|cell proliferation|glucose transport|respiratory gaseous exchange	integral to plasma membrane	endothelin-A receptor activity|phosphatidylinositol phospholipase C activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(4)|lung(3)|ovary(1)	17	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.154)	Bosentan(DB00559)	AATTTTTGCTCTTTGCTGGTT	0.353000													35	97					0	0	1	0	0
PROSER1	80209	broad.mit.edu	37	13	39588502	39588502	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr13:39588502G>C	ENST00000352251.3	-	11	1720	c.887C>G	c.(886-888)tCa>tGa	p.S296*	PROSER1_ENST00000350125.3_Nonsense_Mutation_p.S274*|PROSER1_ENST00000484434.3_Intron	NM_025138.4	NP_079414.3	Q86XN7	CM023_HUMAN	proline and serine rich 1	296	Pro-rich.																TGCTGATGCTGATGGATGATT	0.512000													6	18					0	0	1	0	0
PRPF39	55015	broad.mit.edu	37	14	45581582	45581582	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr14:45581582A>G	ENST00000355765.6	+	11	1804	c.1634A>G	c.(1633-1635)aAt>aGt	p.N545S		NM_017922.3	NP_060392.3	Q86UA1	PRP39_HUMAN	pre-mRNA processing factor 39	545					mRNA processing|RNA splicing	nucleus	binding			breast(2)|endometrium(2)|kidney(4)|lung(3)|ovary(1)	12						CTCAAACAAAATGAAGAAAAT	0.289000													16	24					0	0	1	0	0
EPB41L5	57669	broad.mit.edu	37	2	120849189	120849189	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr2:120849189G>C	ENST00000263713.5	+	13	1316	c.1102G>C	c.(1102-1104)Gaa>Caa	p.E368Q	EPB41L5_ENST00000331393.4_Missense_Mutation_p.E368Q|EPB41L5_ENST00000443902.2_Missense_Mutation_p.E368Q|EPB41L5_ENST00000452780.1_Missense_Mutation_p.E368Q|EPB41L5_ENST00000443124.1_Missense_Mutation_p.E368Q	NM_020909.3	NP_065960.2	Q9HCM4	E41L5_HUMAN	erythrocyte membrane protein band 4.1 like 5	368						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(5)|lung(12)|ovary(1)	26						AACATCCTTTGAAAGAAGGCC	0.368000													19	34					0	0	1	0	0
ZC3HC1	51530	broad.mit.edu	37	7	129658505	129658505	+	Nonstop_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr7:129658505C>G	ENST00000358303.4	-	10	1592	c.1508G>C	c.(1507-1509)tGa>tCa	p.*503S	RP11-306G20.1_ENST00000587038.1_RNA|ZC3HC1_ENST00000360708.5_Nonstop_Mutation_p.*432S|ZC3HC1_ENST00000481503.1_Nonstop_Mutation_p.*460S|ZC3HC1_ENST00000311873.5_Nonstop_Mutation_p.*482S|RP11-306G20.1_ENST00000480018.1_RNA	NM_016478.3	NP_057562.3	Q86WB0	NIPA_HUMAN	zinc finger, C3HC-type containing 1	0					cell division|mitosis	nucleus	protein kinase binding|zinc ion binding			endometrium(2)|kidney(6)|large_intestine(10)|lung(2)|prostate(1)|urinary_tract(1)	22	Melanoma(18;0.0435)					GGAGTATCTTCAGCATGAGCA	0.413000													17	47					0	0	1	0	0
IQUB	154865	broad.mit.edu	37	7	123097453	123097453	+	Silent	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr7:123097453C>T	ENST00000466202.1	-	12	2751	c.2175G>A	c.(2173-2175)aaG>aaA	p.K725K	IQUB_ENST00000324698.6_Silent_p.K725K|RP11-332K15.1_ENST00000419832.1_RNA	NM_001282855.1	NP_001269784.1	Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	725										breast(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(18)|ovary(3)|prostate(2)|stomach(3)|upper_aerodigestive_tract(1)	45						TACTTGTTAGCTTGAGATGAG	0.383000													5	51					0	0	1	0	0
LARP1	23367	broad.mit.edu	37	5	154179579	154179579	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr5:154179579C>T	ENST00000336314.4	+	10	1486	c.1462C>T	c.(1462-1464)Cgg>Tgg	p.R488W		NM_015315.3	NP_056130.2	Q6PKG0	LARP1_HUMAN	La ribonucleoprotein domain family, member 1	565							protein binding|RNA binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	33	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			GAAGAGGCCTCGGCCATCCCC	0.567000													7	15					0	0	1	0	0
CYP24A1	1591	broad.mit.edu	37	20	52779390	52779390	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr20:52779390T>G	ENST00000216862.3	-	7	1249	c.856A>C	c.(856-858)Atc>Ctc	p.I286L	CYP24A1_ENST00000395954.3_Missense_Mutation_p.I144L|CYP24A1_ENST00000395955.3_Missense_Mutation_p.I286L	NM_000782.4	NP_000773.2	Q07973	CP24A_HUMAN	cytochrome P450, family 24, subfamily A, polypeptide 1	286					hormone biosynthetic process|osteoblast differentiation|vitamin D catabolic process|vitamin D receptor signaling pathway|xenobiotic metabolic process	mitochondrial inner membrane	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity|electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen			breast(2)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	24	Lung NSC(4;1.08e-05)|all_lung(4;2.7e-05)		STAD - Stomach adenocarcinoma(23;0.206)		Calcidiol(DB00146)|Calcitriol(DB00136)|Cholecalciferol(DB00169)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	CGGTTGTCGATACAAGCTTTG	0.408000													22	22					0	0	1	0	0
SGOL1	151648	broad.mit.edu	37	3	20202603	20202603	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr3:20202603C>G	ENST00000263753.4	-	9	1819	c.1680G>C	c.(1678-1680)ttG>ttC	p.L560F	SGOL1_ENST00000443724.1_Missense_Mutation_p.L214F|SGOL1_ENST00000383774.1_Missense_Mutation_p.L214F|SGOL1_ENST00000306698.2_Missense_Mutation_p.L291F|SGOL1_ENST00000419233.2_Missense_Mutation_p.L308F|SGOL1_ENST00000452020.1_Missense_Mutation_p.L291F|SGOL1_ENST00000425061.1_Missense_Mutation_p.L308F|SGOL1_ENST00000421451.1_Missense_Mutation_p.L560F	NM_001012410.3|NM_001199252.1	NP_001012410.1|NP_001186181.1	Q5FBB7	SGOL1_HUMAN	shugoshin-like 1 (S. pombe)	560					attachment of spindle microtubules to kinetochore|cell division|centriole-centriole cohesion|meiotic chromosome segregation|mitotic prometaphase	centrosome|condensed chromosome kinetochore|cytosol|mitotic cohesin complex|spindle pole	protein binding			kidney(1)|large_intestine(4)|lung(6)|skin(1)|urinary_tract(2)	14						gactttacctcaagcagatgt	0.368000													68	57					0	0	1	0	0
RC3H1	149041	broad.mit.edu	37	1	173934024	173934024	+	Silent	SNP	T	T	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr1:173934024T>C	ENST00000367696.2	-	10	1920	c.1569A>G	c.(1567-1569)ggA>ggG	p.G523G	RC3H1_ENST00000367694.2_Silent_p.G523G|RC3H1_ENST00000258349.4_Silent_p.G523G			Q5TC82	RC3H1_HUMAN	ring finger and CCCH-type domains 1	523					cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	50						GATCTATTTTTCCTGGTTTCA	0.428000													51	30					0	0	1	0	0
AMER3	205147	broad.mit.edu	37	2	131520826	131520826	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr2:131520826G>A	ENST00000423981.1	+	2	1291	c.1181G>A	c.(1180-1182)gGa>gAa	p.G394E	AMER3_ENST00000321420.4_Missense_Mutation_p.G394E	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		TTCTCGCCAGGACTTGAGGAG	0.612000													7	26					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175063332	175063332	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr1:175063332G>T	ENST00000239462.4	+	7	1644	c.1531G>T	c.(1531-1533)Gtg>Ttg	p.V511L		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	511	Fibronectin type-III 3.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		CAAGGTCTACGTGTGGGCTGA	0.552000													9	31					0.00448238	0.00485258	1	1	0
IQGAP1	8826	broad.mit.edu	37	15	91017821	91017821	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr15:91017821G>T	ENST00000268182.5	+	23	2804	c.2680G>T	c.(2680-2682)Gaa>Taa	p.E894*	IQGAP1_ENST00000560020.1_3'UTR|IQGAP1_ENST00000560738.1_Nonsense_Mutation_p.E322*	NM_003870.3	NP_003861.1	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	894					energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			breast(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|liver(1)|lung(18)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			GAAGATGCGGGAAGAGGTTAT	0.448000													11	39					4.68919e-08	5.60162e-08	1	1	0
AADACL2	344752	broad.mit.edu	37	3	151463418	151463418	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr3:151463418A>G	ENST00000356517.3	+	4	662	c.553A>G	c.(553-555)Att>Gtt	p.I185V		NM_207365.3	NP_997248.2	Q6P093	ADCL2_HUMAN	arylacetamide deacetylase-like 2	185						extracellular region|integral to membrane	carboxylesterase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(4)|liver(1)|lung(13)|skin(2)	24			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			CCGAATCTGCATTGCGGGAGA	0.413000													61	84					0	0	1	0	0
TGFBR2	7048	broad.mit.edu	37	3	30729955	30729955	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr3:30729955G>C	ENST00000295754.5	+	6	1858	c.1476G>C	c.(1474-1476)ttG>ttC	p.L492F	TGFBR2_ENST00000359013.4_Missense_Mutation_p.L517F	NM_003242.5	NP_003233.4	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II (70/80kDa)	492	Protein kinase.				activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(15)|lung(10)|ovary(3)|pancreas(12)|skin(1)|stomach(5)|upper_aerodigestive_tract(2)	53						ACAACGTGTTGAGAGATCGAG	0.483000													30	50					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32640253	32640253	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr2:32640253C>T	ENST00000421745.2	+	10	2028	c.1894C>T	c.(1894-1896)Ctt>Ttt	p.L632F		NM_016252.3	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	632					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					GGTTTTGCTTCTTTATAGCAT	0.373000													5	23					0	0	1	0	0
IRAK1	3654	broad.mit.edu	37	X	153284499	153284499	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chrX:153284499G>C	ENST00000369980.3	-	4	634	c.467C>G	c.(466-468)cCt>cGt	p.P156R	IRAK1_ENST00000393687.2_Missense_Mutation_p.P156R|IRAK1_ENST00000369974.2_Missense_Mutation_p.P156R|IRAK1_ENST00000393682.1_Missense_Mutation_p.P182R|IRAK1_ENST00000429936.2_Missense_Mutation_p.P182R	NM_001025242.1|NM_001569.3	NP_001020413.1|NP_001560.2	P51617	IRAK1_HUMAN	interleukin-1 receptor-associated kinase 1	156	ProST region.				activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|anti-apoptosis|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|lipopolysaccharide-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|protein autophosphorylation|protein oligomerization|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transmembrane receptor protein serine/threonine kinase signaling pathway	cytosol|endosome membrane|interleukin-1 receptor complex	ATP binding|NF-kappaB-inducing kinase activity|protein binding|protein heterodimerization activity|protein homodimerization activity|ubiquitin-protein ligase activity			breast(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(15)|ovary(2)	25	all_cancers(53;3.7e-16)|all_epithelial(53;3.44e-10)|all_lung(58;2.06e-07)|Lung NSC(58;2.72e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GCCGAGCTCAGGCCCTGAATG	0.627000													3	5					0	0	1	0	0
AP2A1	160	broad.mit.edu	37	19	50305798	50305798	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr19:50305798G>C	ENST00000359032.5	+	16	2122	c.2122G>C	c.(2122-2124)Gag>Cag	p.E708Q	AP2A1_ENST00000354293.5_Intron	NM_014203.2	NP_055018.2	O95782	AP2A1_HUMAN	adaptor-related protein complex 2, alpha 1 subunit	708					axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|Golgi to endosome transport|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|clathrin coat of trans-Golgi network vesicle|cytosol	protein binding|protein transporter activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)	19		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.0023)|GBM - Glioblastoma multiforme(134;0.0157)		CAGCGAGCTGGAGCCGCCTGC	0.652000													3	10					0	0	1	0	0
MTMR8	55613	broad.mit.edu	37	X	63445342	63445342	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chrX:63445342G>T	ENST00000453546.1	-	10	1403	c.1314C>A	c.(1312-1314)ttC>ttA	p.F438L	ASB12_ENST00000396130.2_Missense_Mutation_p.F54L|ASB12_ENST00000362002.2_Missense_Mutation_p.F63L			Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	0	Myotubularin phosphatase.					nuclear envelope	protein tyrosine phosphatase activity	p.0?(2)		breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|skin(3)	37						TGCTGTTGATGAAACGTTTGT	0.522000													7	12					0.00198382	0.00215246	1	1	0
ADAM29	11086	broad.mit.edu	37	4	175899008	175899008	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr4:175899008C>T	ENST00000359240.3	+	5	3002	c.2332C>T	c.(2332-2334)Caa>Taa	p.Q778*	RP13-577H12.2_ENST00000507525.1_RNA|ADAM29_ENST00000514159.1_Nonsense_Mutation_p.Q778*|ADAM29_ENST00000404450.4_Nonsense_Mutation_p.Q778*|ADAM29_ENST00000445694.1_Nonsense_Mutation_p.Q778*	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	778	9 X 9 AA approximate repeats.				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		TTCTCAGAGTCAACCTCCTGT	0.567000													31	112					0	0	1	0	0
CLYBL	171425	broad.mit.edu	37	13	100515253	100515253	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr13:100515253C>G	ENST00000376360.1	+	4	474	c.447C>G	c.(445-447)gaC>gaG	p.D149E	CLYBL_ENST00000376354.1_Intron|CLYBL_ENST00000339105.4_Missense_Mutation_p.D149E|CLYBL_ENST00000376355.3_Intron|CLYBL_ENST00000444838.2_Intron			Q8N0X4	CLYBL_HUMAN	citrate lyase beta like	149					cellular aromatic compound metabolic process	citrate lyase complex|mitochondrion	citrate (pro-3S)-lyase activity|metal ion binding			NS(1)|kidney(6)|large_intestine(6)|lung(10)|skin(2)	25	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					AGTTTGCAGACAAATTTTCAT	0.358000													4	60					0	0	1	0	0
HIST1H3G	8355	broad.mit.edu	37	6	26271447	26271447	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:26271447G>A	ENST00000305910.3	-	1	165	c.166C>T	c.(166-168)Cag>Tag	p.Q56*		NM_003534.2	NP_003525.1	P68431	H31_HUMAN	histone cluster 1, H3g	56					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding	p.Q56*(1)		breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	12						GTCGACTTCTGATAGCGGCGA	0.607000													22	79					0	0	1	0	0
SNX17	9784	broad.mit.edu	37	2	27597567	27597567	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr2:27597567C>G	ENST00000233575.2	+	8	845	c.623C>G	c.(622-624)tCt>tGt	p.S208C	SNX17_ENST00000537606.1_Missense_Mutation_p.S183C|SNX17_ENST00000542478.1_5'UTR|SNX17_ENST00000543024.1_5'UTR	NM_001267059.1|NM_001267061.1|NM_014748.3	NP_001253988.1|NP_001253990.1|NP_055563.1	Q15036	SNX17_HUMAN	sorting nexin 17	208					cell communication|endosome transport|intracellular protein transport|regulation of endocytosis|signal transduction	cytoplasmic vesicle membrane|cytosol|early endosome|Golgi apparatus	low-density lipoprotein particle receptor binding|phosphatidylinositol binding|protein C-terminus binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(4)|ovary(1)	14	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TATTGGGACTCTGCCTATGAT	0.512000													20	113					0	0	1	0	0
ERLIN1	10613	broad.mit.edu	37	10	101943528	101943528	+	Silent	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr10:101943528C>A	ENST00000421367.2	-	2	2887	c.180G>T	c.(178-180)acG>acT	p.T60T	ERLIN1_ENST00000407654.3_Silent_p.T60T	NM_001100626.1|NM_006459.3	NP_001094096.1|NP_006450.2	O75477	ERLN1_HUMAN	ER lipid raft associated 1	58					ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane	protein binding						Colorectal(252;0.234)		Epithelial(162;3.85e-10)|all cancers(201;3.25e-08)		CAGATCTGAACGTAGTAATGA	0.443000													4	38					8.12818e-05	9.16784e-05	1	1	0
CASZ1	54897	broad.mit.edu	37	1	10725290	10725290	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr1:10725290C>T	ENST00000377022.3	-	5	672	c.355G>A	c.(355-357)Gag>Aag	p.E119K	CASZ1_ENST00000478728.2_5'UTR|CASZ1_ENST00000344008.5_Missense_Mutation_p.E119K	NM_001079843.2	NP_001073312.1	Q86V15	CASZ1_HUMAN	castor zinc finger 1	119					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|large_intestine(13)|lung(18)|ovary(2)|prostate(5)|skin(2)|urinary_tract(1)	54	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		TAGACACCCTCGGGAGGCAGC	0.672000													19	58					0	0	1	0	0
RPGRIP1L	23322	broad.mit.edu	37	16	53726245	53726245	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr16:53726245C>A	ENST00000262135.4	-	4	355	c.262G>T	c.(262-264)Gac>Tac	p.D88Y	RPGRIP1L_ENST00000564374.1_Missense_Mutation_p.D88Y|RPGRIP1L_ENST00000563746.1_Missense_Mutation_p.D88Y|RPGRIP1L_ENST00000379925.3_Missense_Mutation_p.D88Y	NM_001127897.1	NP_001121369.1	Q68CZ1	FTM_HUMAN	RPGRIP1-like	88					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			endometrium(6)|kidney(3)|large_intestine(9)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(2)	46		all_cancers(37;0.0973)				CTTTTCTTGTCATTAACTAGC	0.428000													26	123					9.57634e-11	1.16991e-10	1	1	0
TAF1L	138474	broad.mit.edu	37	9	32635516	32635516	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr9:32635516G>C	ENST00000242310.4	-	1	151	c.62C>G	c.(61-63)tCa>tGa	p.S21*	RP11-555J4.4_ENST00000430787.1_RNA	NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	21					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		GTCCGAGTCTGACATGATGGC	0.557000													30	11					0	0	1	0	0
RAB2A	5862	broad.mit.edu	37	8	61504457	61504457	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr8:61504457G>T	ENST00000262646.7	+	6	754	c.403G>T	c.(403-405)Gaa>Taa	p.E135*	RAB2A_ENST00000530071.1_3'UTR|RAB2A_ENST00000529579.1_Intron|RAB2A_ENST00000531289.1_Nonsense_Mutation_p.E111*	NM_002865.2	NP_002856.1	P61019	RAB2A_HUMAN	RAB2A, member RAS oncogene family	135					ER to Golgi vesicle-mediated transport|protein transport|small GTPase mediated signal transduction	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|melanosome	GDP binding|GTP binding|GTPase activity			endometrium(1)|large_intestine(1)|lung(4)	6			BRCA - Breast invasive adenocarcinoma(89;0.0805)			AGAAGAAGGTGAAGCTTTTGC	0.368000													24	71					1.16021e-09	1.41028e-09	1	1	0
AMOT	154796	broad.mit.edu	37	X	112022306	112022306	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chrX:112022306C>T	ENST00000371959.3	-	10	3075	c.3076G>A	c.(3076-3078)Gag>Aag	p.E1026K	AMOT_ENST00000524145.1_Missense_Mutation_p.E1026K|AMOT_ENST00000304758.1_Missense_Mutation_p.E617K|AMOT_ENST00000371962.1_Missense_Mutation_p.E794K	NM_001113490.1	NP_001106962.1	Q4VCS5	AMOT_HUMAN	angiomotin	1026					actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction	angiostatin binding|protein binding|receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	43						GCAGGAACCTCAGCCTGAGCC	0.537000													4	77					0	0	1	0	0
CIT	11113	broad.mit.edu	37	12	120306966	120306966	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr12:120306966G>T	ENST00000392521.2	-	3	191	c.136C>A	c.(136-138)Ctt>Att	p.L46I	CIT_ENST00000261833.7_Missense_Mutation_p.L46I	NM_001206999.1	NP_001193928.1	O14578	CTRO_HUMAN	citron (rho-interacting, serine/threonine kinase 21)	46					intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			breast(6)|endometrium(9)|kidney(4)|large_intestine(15)|liver(1)|lung(29)|ovary(7)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	86	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		TCTCGGGAAAGAGGAGACATC	0.428000													35	121					3.93418e-24	5.04783e-24	1	1	0
CCDC158	339965	broad.mit.edu	37	4	77300523	77300523	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr4:77300523G>T	ENST00000388914.3	-	8	1101	c.949C>A	c.(949-951)Cgt>Agt	p.R317S	CCDC158_ENST00000434846.2_Missense_Mutation_p.R317S	NM_001042784.1	NP_001036249.1	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	317										breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(1)	56						CTGAGCTGACGCATATACATA	0.398000													15	42					6.72482e-11	8.23621e-11	1	1	0
PXDNL	137902	broad.mit.edu	37	8	52284499	52284499	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr8:52284499G>A	ENST00000356297.4	-	19	3935	c.3835C>T	c.(3835-3837)Cag>Tag	p.Q1279*	PXDNL_ENST00000543296.1_Nonsense_Mutation_p.Q1279*	NM_144651.4	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	1279					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				AGGTAATCCTGTGGGTATTCT	0.527000													11	20					0	0	1	0	0
MIEN1	84299	broad.mit.edu	37	17	37886004	37886004	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr17:37886004C>G	ENST00000394231.3	-	3	489	c.198G>C	c.(196-198)gaG>gaC	p.E66D	ERBB2_ENST00000584888.1_Intron|MIEN1_ENST00000577810.1_Missense_Mutation_p.E66D|MIEN1_ENST00000474210.1_5'UTR			Q9BRT3	CQ037_HUMAN	migration and invasion enhancer 1	66					cell redox homeostasis	cytosol|membrane	selenium binding										TTATCTCTATCTCAAAGGCAC	0.488000													4	129					0	0	1	0	0
CCDC88C	440193	broad.mit.edu	37	14	91763750	91763750	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr14:91763750C>A	ENST00000389857.6	-	22	3951	c.3865G>T	c.(3865-3867)Gcg>Tcg	p.A1289S		NM_001080414.3	NP_001073883.2	Q9P219	DAPLE_HUMAN	coiled-coil domain containing 88C	1289					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(6)|pancreas(1)|urinary_tract(1)	24		all_cancers(154;0.0468)				TCCAGCTGCGCGTTGTTCAGT	0.597000													3	22					1	1	1	1	0
WAS	7454	broad.mit.edu	37	X	48547079	48547079	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chrX:48547079G>C	ENST00000376701.4	+	10	1037	c.962G>C	c.(961-963)cGa>cCa	p.R321P		NM_000377.2	NP_000368.1	P42768	WASP_HUMAN	Wiskott-Aldrich syndrome	321					blood coagulation|defense response|epidermis development|immune response|T cell receptor signaling pathway	actin cytoskeleton|cytosol	identical protein binding|small GTPase regulator activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)	28		all_lung(315;1.27e-10)				CCGCCATCTCGAGGAGGGAAC	0.587000			"""Mis, N, F, S"""			lymphoma							5	9					0	0	1	0	0
MLLT4-AS1	653483	broad.mit.edu	37	6	168227233	168227233	+	RNA	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:168227233C>T	ENST00000359760.5	-	0	156					NR_027906.1																						GATCCAGCACCGCCCGTCCGG	0.647000													11	46					0	0	1	0	0
KIF9	64147	broad.mit.edu	37	3	47288960	47288960	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr3:47288960C>T	ENST00000335044.2	-	12	1493	c.1136G>A	c.(1135-1137)cGc>cAc	p.R379H	KIF9_ENST00000265529.3_Missense_Mutation_p.R379H|KIF9_ENST00000352910.4_Missense_Mutation_p.R286H|KIF9_ENST00000444589.2_Missense_Mutation_p.R379H|KIF9_ENST00000487440.1_5'UTR|KIF9_ENST00000452770.2_Missense_Mutation_p.R379H	NM_001134878.1|NM_182902.3	NP_001128350.1|NP_878905.2	Q9HAQ2	KIF9_HUMAN	kinesin family member 9	379					blood coagulation|microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(15)|skin(4)|stomach(2)|upper_aerodigestive_tract(2)	34		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000284)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		CACAAAGGTGCGGTTGGTCTT	0.547000													10	70					0	0	1	0	0
FOXRED1	55572	broad.mit.edu	37	11	126147485	126147485	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr11:126147485G>C	ENST00000263578.5	+	11	1436	c.1362G>C	c.(1360-1362)gaG>gaC	p.E454D	FOXRED1_ENST00000442061.2_Missense_Mutation_p.E284D|FOXRED1_ENST00000534011.1_3'UTR|FOXRED1_ENST00000532125.1_Missense_Mutation_p.E440D	NM_017547.3	NP_060017.1	Q96CU9	FXRD1_HUMAN	FAD-dependent oxidoreductase domain containing 1	454						integral to membrane|mitochondrion	oxidoreductase activity|protein binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(1)	15	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0739)|all_lung(97;0.0798)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0729)		CTGTAGCAGAGATGGTACTGA	0.562000													4	58					0	0	1	0	0
PBDC1	51260	broad.mit.edu	37	X	75396809	75396809	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chrX:75396809G>A	ENST00000373358.3	+	5	594	c.391G>A	c.(391-393)Gag>Aag	p.E131K	PBDC1_ENST00000373357.3_Intron	NM_016500.3	NP_057584.2			polysaccharide biosynthesis domain containing 1																		GGGCTACACTGAGGAAAACAC	0.413000													15	27					0	0	1	0	0
CCDC8	83987	broad.mit.edu	37	19	46914975	46914975	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr19:46914975C>G	ENST00000307522.3	-	1	1866	c.1093G>C	c.(1093-1095)Gat>Cat	p.D365H		NM_032040.4	NP_114429.2	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	365						plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		CTCTGATTATCTGCAGCCTCT	0.592000													6	169					0	0	1	0	0
RAB3GAP2	25782	broad.mit.edu	37	1	220379266	220379266	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr1:220379266C>T	ENST00000358951.2	-	8	811	c.695G>A	c.(694-696)cGa>cAa	p.R232Q		NM_012414.3	NP_036546.2	Q9H2M9	RBGPR_HUMAN	RAB3 GTPase activating protein subunit 2 (non-catalytic)	232					intracellular protein transport	cytoplasm|soluble fraction	GTPase activator activity|protein heterodimerization activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(1)	39				GBM - Glioblastoma multiforme(131;0.0443)		TACCTGATTTCGACAAGCACG	0.303000													12	20					0	0	1	0	0
TSC22D2	9819	broad.mit.edu	37	3	150176290	150176290	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr3:150176290C>G	ENST00000361875.3	+	4	3226	c.2210C>G	c.(2209-2211)tCa>tGa	p.S737*	TSC22D2_ENST00000361136.2_Nonsense_Mutation_p.S713*	NM_014779.2	NP_055594.1	O75157	T22D2_HUMAN	TSC22 domain family, member 2								sequence-specific DNA binding transcription factor activity			cervix(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	18			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			AAATCTCTTTCAAGCAATGAT	0.408000													27	84					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121312970	121312970	+	Splice_Site	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr8:121312970G>T	ENST00000297848.3	+	36	4584		c.e36-1		COL14A1_ENST00000309791.4_Splice_Site|COL14A1_ENST00000247781.3_Splice_Site	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1						cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TTTCTTTTCAGAGAGATGATG	0.423000													37	251					4.32679e-17	5.45063e-17	1	1	0
PPP3CC	5533	broad.mit.edu	37	8	22398300	22398300	+	Silent	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr8:22398300G>A	ENST00000240139.5	+	14	1851	c.1524G>A	c.(1522-1524)aaG>aaA	p.K508K	PPP3CC_ENST00000397775.3_Silent_p.K517K|PPP3CC_ENST00000289963.8_Silent_p.K498K	NM_005605.4	NP_005596.2	P48454	PP2BC_HUMAN	protein phosphatase 3, catalytic subunit, gamma isozyme	508					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals	cytosol	calmodulin binding|metal ion binding|phosphoprotein phosphatase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17		Prostate(55;0.104)		BRCA - Breast invasive adenocarcinoma(99;0.00756)|Colorectal(74;0.0238)|COAD - Colon adenocarcinoma(73;0.0835)		ACCAAGGGAAGAAAGCCCATT	0.458000													5	8					0	0	1	0	0
ZIC1	7545	broad.mit.edu	37	3	147131158	147131158	+	Silent	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr3:147131158G>T	ENST00000282928.4	+	3	1893	c.1164G>T	c.(1162-1164)tcG>tcT	p.S388S		NM_003412.3	NP_003403.2	Q15915	ZIC1_HUMAN	Zic family member 1	388	Ser-rich.				behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(4)|cervix(1)|endometrium(2)|large_intestine(8)|lung(38)|ovary(1)|prostate(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	63						AATCCTCCTCGCAGGGCTCGC	0.622000													5	66					8.12818e-05	9.16784e-05	1	1	0
NEUROD1	4760	broad.mit.edu	37	2	182542962	182542962	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr2:182542962G>A	ENST00000295108.3	-	2	1083	c.626C>T	c.(625-627)aCg>aTg	p.T209M	NEUROD1_ENST00000496876.1_Intron|CERKL_ENST00000479558.1_Intron	NM_002500.4	NP_002491.2	Q13562	NDF1_HUMAN	neuronal differentiation 1	209					amacrine cell differentiation|cerebellum development|dentate gyrus development|embryonic organ morphogenesis|enteroendocrine cell differentiation|glucose homeostasis|inner ear development|insulin secretion|negative regulation of apoptosis|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of intestinal epithelial structure maintenance|response to glucose stimulus	cytoplasm|nucleus	chromatin binding|E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25			OV - Ovarian serous cystadenocarcinoma(117;0.088)			AGCGCTGGCCGTCGGCAGGTG	0.612000													18	51					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32705945	32705945	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr13:32705945G>T	ENST00000380250.3	+	8	1349	c.853G>T	c.(853-855)Gag>Tag	p.E285*		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	285					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		GTATCCAGTGGAGGATTTTGA	0.408000													16	52					0.000566183	0.000632716	1	1	0
PLEC	5339	broad.mit.edu	37	8	144993062	144993062	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr8:144993062C>A	ENST00000322810.4	-	32	11507	c.11338G>T	c.(11338-11340)Gtg>Ttg	p.V3780L	PLEC_ENST00000354589.3_Missense_Mutation_p.V3643L|PLEC_ENST00000356346.3_Missense_Mutation_p.V3629L|PLEC_ENST00000436759.2_Missense_Mutation_p.V3670L|PLEC_ENST00000354958.2_Missense_Mutation_p.V3621L|PLEC_ENST00000357649.2_Missense_Mutation_p.V3647L|PLEC_ENST00000398774.2_Missense_Mutation_p.V3611L|PLEC_ENST00000527096.1_Missense_Mutation_p.V3666L|PLEC_ENST00000345136.3_Missense_Mutation_p.V3643L	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	3780	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						CGGCGGCGCACGTAGTCGTAG	0.617000													14	120					3.27435e-08	3.93084e-08	1	1	0
AASS	10157	broad.mit.edu	37	7	121731806	121731806	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr7:121731806C>A	ENST00000393376.1	-	17	2062	c.1967G>T	c.(1966-1968)gGa>gTa	p.G656V	AASS_ENST00000473553.1_5'UTR|AASS_ENST00000417368.2_Missense_Mutation_p.G656V			Q9UDR5	AASS_HUMAN	aminoadipate-semialdehyde synthase	656	Saccharopine dehydrogenase.				protein tetramerization	mitochondrial matrix	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity			autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(6)|large_intestine(12)|lung(27)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	54					L-Glutamic Acid(DB00142)|NADH(DB00157)	CATCAAAACTCCCACTGGACT	0.403000													6	15					0.0215528	0.0225769	1	1	0
SLITRK5	26050	broad.mit.edu	37	13	88328749	88328749	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr13:88328749C>T	ENST00000325089.6	+	2	1325	c.1106C>T	c.(1105-1107)cCg>cTg	p.P369L	SLITRK5_ENST00000400028.3_Missense_Mutation_p.P128L	NM_015567.1	NP_056382.1	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5	369	LRRNT.					integral to membrane				breast(1)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(14)|lung(40)|ovary(2)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(4)	81	all_neural(89;0.101)|Medulloblastoma(90;0.163)					ACCAAATCCCCGGTGCCTTTG	0.592000													20	37					0	0	1	0	0
KRTAP19-5	337972	broad.mit.edu	37	21	31874295	31874295	+	Silent	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr21:31874295G>A	ENST00000334151.2	-	1	140	c.114C>T	c.(112-114)ggC>ggT	p.G38G		NM_181611.1	NP_853642.1	Q3LI72	KR195_HUMAN	keratin associated protein 19-5	38						intermediate filament	protein binding			endometrium(1)|large_intestine(5)|lung(4)|pancreas(1)|prostate(1)	12						CGTAGCCACCGCCATAGCCCA	0.577000													58	109					0	0	1	0	0
PDZD8	118987	broad.mit.edu	37	10	119042868	119042868	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr10:119042868C>G	ENST00000334464.5	-	5	3615	c.3376G>C	c.(3376-3378)Gac>Cac	p.D1126H		NM_173791.3	NP_776152.1	Q8NEN9	PDZD8_HUMAN	PDZ domain containing 8	1126					intracellular signal transduction		metal ion binding			kidney(3)|large_intestine(8)|lung(24)|upper_aerodigestive_tract(3)	38		Colorectal(252;0.19)		all cancers(201;0.0121)		TTATCAAGGTCTTCTTCTGTA	0.398000													20	59					0	0	1	0	0
ABCE1	6059	broad.mit.edu	37	4	146031388	146031388	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr4:146031388C>A	ENST00000296577.4	+	6	1054	c.539C>A	c.(538-540)gCa>gAa	p.A180E	ABCE1_ENST00000502803.1_Intron	NM_001040876.1|NM_002940.2	NP_001035809.1|NP_002931.2	P61221	ABCE1_HUMAN	ATP-binding cassette, sub-family E (OABP), member 1	180	ABC transporter 1.				interspecies interaction between organisms|response to virus|RNA catabolic process	mitochondrion	ATP binding|ATPase activity|electron carrier activity|iron-sulfur cluster binding|ribonuclease inhibitor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|lung(5)|prostate(2)|skin(3)	18	all_hematologic(180;0.151)					CCTAAGGCTGCAAAGGTCGGT	0.308000													35	65					2.52637e-11	3.102e-11	1	1	0
AP3B1	8546	broad.mit.edu	37	5	77311345	77311345	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr5:77311345G>C	ENST00000255194.6	-	26	3195	c.3020C>G	c.(3019-3021)tCt>tGt	p.S1007C	AP3B1_ENST00000519295.1_Missense_Mutation_p.S958C	NM_001271769.1	NP_001258698.1	O00203	AP3B1_HUMAN	adaptor-related protein complex 3, beta 1 subunit	1007					endocytosis|melanosome organization	clathrin coated vesicle membrane|Golgi apparatus|membrane coat	protein phosphatase binding|protein transporter activity			breast(5)|central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(12)|lung(12)|prostate(1)|skin(2)|urinary_tract(1)	39		all_lung(232;0.000397)|Lung NSC(167;0.00106)|Ovarian(174;0.0105)|Prostate(461;0.215)		OV - Ovarian serous cystadenocarcinoma(54;8.23e-47)|Epithelial(54;2.74e-41)|all cancers(79;4.8e-36)		GATTACAGCAGAAGTTTCATT	0.378000									Hermansky-Pudlak syndrome				17	36					0	0	1	0	0
PTK2	5747	broad.mit.edu	37	8	141889681	141889681	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr8:141889681C>A	ENST00000522684.1	-	4	480	c.251G>T	c.(250-252)gGa>gTa	p.G84V	PTK2_ENST00000535192.1_Missense_Mutation_p.G84V|PTK2_ENST00000521059.1_Missense_Mutation_p.G84V|PTK2_ENST00000519881.1_Missense_Mutation_p.G84V|PTK2_ENST00000340930.3_Missense_Mutation_p.G84V|PTK2_ENST00000395218.2_Missense_Mutation_p.G84V|PTK2_ENST00000517887.1_Missense_Mutation_p.G128V|PTK2_ENST00000520892.1_Missense_Mutation_p.G84V|PTK2_ENST00000519419.1_Missense_Mutation_p.G128V	NM_153831.3	NP_722560.1	Q05397	FAK1_HUMAN	protein tyrosine kinase 2	84	FERM.				axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(6)|lung(23)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	48	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)			GAGGCGGAATCCATAGCAGGC	0.488000													5	221					3.59834e-05	4.10634e-05	1	1	0
ZNF559	84527	broad.mit.edu	37	19	9453063	9453063	+	Silent	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr19:9453063C>G	ENST00000393883.2	+	6	1584	c.936C>G	c.(934-936)ctC>ctG	p.L312L	ZNF559_ENST00000317221.7_3'UTR|ZNF177_ENST00000446085.4_Intron|ZNF177_ENST00000602856.1_Intron|ZNF559_ENST00000592896.1_3'UTR|ZNF177_ENST00000602738.1_Intron|ZNF559_ENST00000587557.1_Silent_p.L376L|ZNF559_ENST00000538743.1_Silent_p.L232L|ZNF559_ENST00000603380.1_Silent_p.L312L|ZNF177_ENST00000541595.2_Intron|ZNF177_ENST00000605471.1_Intron|ZNF559_ENST00000586255.1_Intron	NM_001202412.1	NP_001189341.1	Q9BR84	ZN559_HUMAN	zinc finger protein 559	312					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|large_intestine(7)|lung(15)|ovary(1)|urinary_tract(1)	26						TCTCAAAACTCAACATTCACA	0.368000													19	56					0	0	1	0	0
PCDHA12	56137	broad.mit.edu	37	5	140256840	140256840	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr5:140256840C>T	ENST00000398631.2	+	1	1783	c.1783C>T	c.(1783-1785)Cgc>Tgc	p.R595C	PCDHA1_ENST00000394633.3_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA4_ENST00000512229.2_Intron	NM_018903.2|NM_031864.2	NP_061726.1|NP_114070.1														NS(4)|breast(2)|cervix(1)|endometrium(19)|kidney(8)|large_intestine(8)|liver(2)|lung(25)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCGAAAGTGCGCGCGGTGGA	0.697000													22	77					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141283903	141283903	+	Silent	SNP	C	C	A	rs144688014		TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr2:141283903C>A	ENST00000389484.3	-	48	8750	c.7779G>T	c.(7777-7779)acG>acT	p.T2593T		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2593	LDL-receptor class A 13.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GGAACTCAACCGTGGCACAGG	0.388000										TSP Lung(27;0.18)			4	51					0.000602214	0.000665317	1	1	0
LINC00264	645528	broad.mit.edu	37	10	26880266	26880266	+	RNA	SNP	G	G	A	rs138111133	by1000genomes	TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr10:26880266G>A	ENST00000412114.1	+	0	501					NR_026793.1																						ACCAAGCCCAGTGGACAGATG	0.443000													3	47					0	0	1	0	0
XPO4	64328	broad.mit.edu	37	13	21370907	21370907	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr13:21370907C>A	ENST00000400602.2	-	17	2647	c.2612G>T	c.(2611-2613)gGa>gTa	p.G871V	XPO4_ENST00000255305.6_Missense_Mutation_p.G871V	NM_022459.4	NP_071904.4	Q9C0E2	XPO4_HUMAN	exportin 4	871					protein transport	cytoplasm|nucleus	protein binding			breast(1)|endometrium(10)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	41		all_cancers(29;5.05e-24)|all_epithelial(30;5.56e-20)|all_lung(29;2.38e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000521)|Epithelial(112;0.000892)|OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Lung(94;0.0189)|LUSC - Lung squamous cell carcinoma(192;0.0548)		GCTTACCTCTCCAAGATAGCA	0.313000													4	38					1.024e-07	1.21428e-07	1	1	0
SV2B	9899	broad.mit.edu	37	15	91795180	91795180	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr15:91795180G>T	ENST00000394232.1	+	3	1053	c.583G>T	c.(583-585)Gtg>Ttg	p.V195L	SV2B_ENST00000330276.4_Missense_Mutation_p.V195L|SV2B_ENST00000545111.2_Missense_Mutation_p.V44L	NM_014848.4	NP_055663.1	Q7L1I2	SV2B_HUMAN	synaptic vesicle glycoprotein 2B	195					neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			NS(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(17)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	42	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			CTCTTCCTTCGTGCAGGGATA	0.587000													14	38					5.3912e-06	6.28542e-06	1	1	0
TFE3	7030	broad.mit.edu	37	X	48888996	48888996	+	Silent	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chrX:48888996C>T	ENST00000315869.7	-	9	1459	c.1200G>A	c.(1198-1200)caG>caA	p.Q400Q	TFE3_ENST00000487451.1_5'UTR	NM_006521.4	NP_006512.2	P19532	TFE3_HUMAN	transcription factor binding to IGHM enhancer 3	400	Helix-loop-helix motif.				humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding		NONO/TFE3(2)|PRCC/TFE3(25)|SFPQ/TFE3(6)|CLTC/TFE3(2)|ASPSCR1/TFE3(167)	central_nervous_system(1)	1						GCTGCTCCTTCTGCAGCTTGC	0.592000			T	"""SFPQ, ASPSCR1, PRCC, NONO, CLTC"""	"""papillary renal, alveolar soft part sarcoma, renal"""								7	6					0	0	1	0	0
ICAM3	3385	broad.mit.edu	37	19	10445851	10445851	+	Silent	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr19:10445851G>T	ENST00000589261.1	-	4	1129	c.597C>A	c.(595-597)gcC>gcA	p.A199A	ICAM3_ENST00000160262.5_Silent_p.A276A			P32942	ICAM3_HUMAN	intercellular adhesion molecule 3	276					cell-cell adhesion|regulation of immune response	integral to plasma membrane	integrin binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|upper_aerodigestive_tract(2)	13			OV - Ovarian serous cystadenocarcinoma(20;6.13e-09)|Epithelial(33;9.69e-06)|all cancers(31;2.05e-05)			CTGTGGCTGTGGCCGTTAGCG	0.652000													5	152					0.217242	0.218594	1	1	0
IL1F10	84639	broad.mit.edu	37	2	113832779	113832779	+	Silent	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr2:113832779C>T	ENST00000393197.2	+	4	718	c.297C>T	c.(295-297)ttC>ttT	p.F99F	IL1F10_ENST00000337569.3_Silent_p.F99F|IL1F10_ENST00000341010.2_Silent_p.F99F	NM_032556.5	NP_115945.4	Q8WWZ1	IL1FA_HUMAN	interleukin 1 family, member 10 (theta)	99						extracellular space	cytokine activity|interleukin-1 receptor antagonist activity			endometrium(1)|lung(6)|ovary(1)	8						CCACACGCTTCACCTTCTTCC	0.597000													10	204					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82816062	82816062	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr5:82816062C>T	ENST00000265077.3	+	7	2502	c.1937C>T	c.(1936-1938)cCa>cTa	p.P646L	VCAN_ENST00000512590.2_Missense_Mutation_p.P598L|VCAN_ENST00000342785.4_Missense_Mutation_p.P646L|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000343200.5_Intron	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	646	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		ACACCTTTTCCATCACAGCAT	0.363000													14	49					0	0	1	0	0
CLASP1	23332	broad.mit.edu	37	2	122363383	122363383	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr2:122363383T>C	ENST00000263710.4	-	2	478	c.89A>G	c.(88-90)tAt>tGt	p.Y30C	CLASP1_ENST00000541377.1_Missense_Mutation_p.Y30C|CLASP1_ENST00000397587.3_Missense_Mutation_p.Y30C|CLASP1_ENST00000455322.2_Missense_Mutation_p.Y30C|CLASP1_ENST00000409078.3_Missense_Mutation_p.Y30C	NM_015282.2	NP_056097.1	Q7Z460	CLAP1_HUMAN	cytoplasmic linker associated protein 1	30					axon guidance|cell division|establishment or maintenance of cell polarity|exit from mitosis|G2/M transition of mitotic cell cycle|microtubule anchoring|microtubule bundle formation|microtubule nucleation|microtubule organizing center organization|mitotic prometaphase|negative regulation of microtubule depolymerization	centrosomal corona|condensed chromosome kinetochore|cortical microtubule cytoskeleton|cytoplasmic microtubule|cytosol|Golgi apparatus|kinetochore microtubule	kinetochore binding|microtubule plus-end binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(1)	47	Renal(3;0.0496)					GTCTGAGAAATAGTCTATCAG	0.483000													11	59					0	0	1	0	0
RNF166	115992	broad.mit.edu	37	16	88767738	88767738	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr16:88767738C>A	ENST00000312838.4	-	2	339	c.244G>T	c.(244-246)Gac>Tac	p.D82Y	RNF166_ENST00000541206.2_5'UTR|RNF166_ENST00000562499.1_5'UTR|RNF166_ENST00000567844.1_Intron	NM_178841.3	NP_849163.1	Q96A37	RN166_HUMAN	ring finger protein 166	82						intracellular	zinc ion binding			endometrium(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0476)		GTGGCCTTGTCCACCTTCTTG	0.657000													8	47					0.0581538	0.0600097	1	1	0
PSKH2	85481	broad.mit.edu	37	8	87076599	87076599	+	Silent	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr8:87076599G>A	ENST00000276616.2	-	2	521	c.447C>T	c.(445-447)ctC>ctT	p.L149L	PSKH2_ENST00000517981.1_5'UTR	NM_033126.1	NP_149117.1	Q96QS6	KPSH2_HUMAN	protein serine kinase H2	149	Protein kinase.						ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|kidney(11)|large_intestine(2)|lung(26)|ovary(1)|prostate(1)|stomach(3)|urinary_tract(1)	47			STAD - Stomach adenocarcinoma(118;0.129)			CCTGAGCAATGAGTCGATCAA	0.498000													15	52					0	0	1	0	0
RIF1	55183	broad.mit.edu	37	2	152315394	152315394	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr2:152315394G>T	ENST00000243326.5	+	24	3408	c.2925G>T	c.(2923-2925)atG>atT	p.M975I	RIF1_ENST00000430328.2_Missense_Mutation_p.M975I|RIF1_ENST00000428287.2_Missense_Mutation_p.M975I|RIF1_ENST00000444746.2_Missense_Mutation_p.M975I|RIF1_ENST00000453091.2_Missense_Mutation_p.M975I			Q5UIP0	RIF1_HUMAN	RAP1 interacting factor homolog (yeast)						cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			NS(2)|breast(8)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(19)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	97				BRCA - Breast invasive adenocarcinoma(221;0.0429)		TTGAAATGATGGAGGAATCCA	0.328000													3	53					0.150653	0.15286	1	1	0
THNSL1	79896	broad.mit.edu	37	10	25313774	25313774	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr10:25313774C>G	ENST00000524413.1	+	3	1969	c.1622C>G	c.(1621-1623)aCt>aGt	p.T541S	THNSL1_ENST00000376356.4_Missense_Mutation_p.T541S			Q8IYQ7	THNS1_HUMAN	threonine synthase-like 1 (S. cerevisiae)	541					threonine biosynthetic process		ATP binding|pyridoxal phosphate binding|shikimate kinase activity|threonine synthase activity			NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(5)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	28					L-Threonine(DB00156)|Pyridoxal Phosphate(DB00114)	CATGTTTTGACTGATTTTATA	0.353000													31	50					0	0	1	0	0
TAB2	23118	broad.mit.edu	37	6	149700405	149700405	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:149700405C>T	ENST00000367456.1	+	4	1931	c.1354C>T	c.(1354-1356)Cga>Tga	p.R452*	TAB2_ENST00000286332.5_Nonsense_Mutation_p.R452*|TAB2_ENST00000538427.1_Nonsense_Mutation_p.R452*|TAB2_ENST00000392282.1_Nonsense_Mutation_p.R452*|TAB2_ENST00000536230.1_Nonsense_Mutation_p.R420*			Q9NYJ8	TAB2_HUMAN	TGF-beta activated kinase 1/MAP3K7 binding protein 2	452					activation of MAPK activity|heart development|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	K63-linked polyubiquitin binding|zinc ion binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|urinary_tract(1)	22						AACCTCTCCTCGAGTGGTAGT	0.498000													25	54					0	0	1	0	0
ABLIM2	84448	broad.mit.edu	37	4	8082509	8082509	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr4:8082509C>T	ENST00000296372.8	-	5	617	c.475G>A	c.(475-477)Gaa>Aaa	p.E159K	ABLIM2_ENST00000361581.5_Missense_Mutation_p.E159K|ABLIM2_ENST00000341937.5_Missense_Mutation_p.E159K|ABLIM2_ENST00000318888.4_5'UTR|ABLIM2_ENST00000545242.1_Missense_Mutation_p.E159K|ABLIM2_ENST00000361737.5_Missense_Mutation_p.E159K|ABLIM2_ENST00000546334.1_Missense_Mutation_p.E159K|ABLIM2_ENST00000505872.1_Missense_Mutation_p.E159K|ABLIM2_ENST00000428004.2_Missense_Mutation_p.E159K|ABLIM2_ENST00000447017.2_Missense_Mutation_p.E159K|ABLIM2_ENST00000407564.3_Missense_Mutation_p.E159K			Q6H8Q1	ABLM2_HUMAN	actin binding LIM protein family, member 2	159	LIM zinc-binding 3.				axon guidance|cytoskeleton organization	actin cytoskeleton|cytoplasm|intermediate filament cytoskeleton|nucleus	actin binding|zinc ion binding	p.E159K(1)		NS(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(6)|pancreas(3)|prostate(2)|urinary_tract(1)	25						TTCTTGATTTCTGTGCCGCAG	0.557000													12	28					0	0	1	0	0
GRIK2	2898	broad.mit.edu	37	6	102337649	102337649	+	Silent	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:102337649C>T	ENST00000369138.1	+	11	2149	c.1659C>T	c.(1657-1659)ttC>ttT	p.F553F	GRIK2_ENST00000413795.1_Silent_p.F553F|GRIK2_ENST00000318991.6_Silent_p.F553F|GRIK2_ENST00000369137.3_Intron|GRIK2_ENST00000369134.4_Silent_p.F504F|GRIK2_ENST00000421544.1_Silent_p.F553F	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	553					glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	CAGGCGTCTTCTCCTTCCTGA	0.463000													70	91					0	0	1	0	0
ZKSCAN2	342357	broad.mit.edu	37	16	25268336	25268336	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr16:25268336G>A	ENST00000328086.7	-	1	916	c.113C>T	c.(112-114)tCg>tTg	p.S38L		NM_001012981.4	NP_001012999.3	Q63HK3	ZKSC2_HUMAN	zinc finger with KRAB and SCAN domains 2	38					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	36				GBM - Glioblastoma multiforme(48;0.0378)		AGAGCTATCCGATCCTTCCAG	0.517000											OREG0023690	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	52					0	0	1	0	0
FOLR3	2352	broad.mit.edu	37	11	71850672	71850672	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr11:71850672G>C	ENST00000445078.2	+	5	726	c.655G>C	c.(655-657)Gag>Cag	p.E219Q	FOLR3_ENST00000456237.1_Missense_Mutation_p.E221Q|FOLR3_ENST00000442948.2_Missense_Mutation_p.E178Q			P41439	FOLR3_HUMAN	folate receptor 3 (gamma)	177					folic acid transport	extracellular region|extrinsic to membrane|membrane fraction	folic acid binding|receptor activity			large_intestine(3)|lung(8)|prostate(2)	13					Folic Acid(DB00158)	CAGCACCTTTGAGTCCTACTT	0.607000													11	59					0	0	1	0	0
TRAF3IP2	10758	broad.mit.edu	37	6	111884237	111884237	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:111884237C>A	ENST00000368761.5	-	8	1960	c.1482G>T	c.(1480-1482)caG>caT	p.Q494H	TRAF3IP2_ENST00000392556.4_Missense_Mutation_p.Q82H|TRAF3IP2_ENST00000368731.2_5'UTR|TRAF3IP2-AS1_ENST00000532353.1_RNA|TRAF3IP2_ENST00000368735.1_Missense_Mutation_p.Q38H|TRAF3IP2_ENST00000340026.6_Missense_Mutation_p.Q503H|TRAF3IP2-AS1_ENST00000442928.2_RNA|TRAF3IP2-AS1_ENST00000456352.2_RNA|TRAF3IP2-AS1_ENST00000449449.2_RNA|TRAF3IP2-AS1_ENST00000438298.2_RNA|TRAF3IP2_ENST00000359831.4_Missense_Mutation_p.Q493H|TRAF3IP2-AS1_ENST00000440395.1_RNA	NM_001164281.2|NM_147686.3	NP_001157753.1|NP_679211.2	O43734	CIKS_HUMAN	TRAF3 interacting protein 2	503	SEFIR.				intracellular signal transduction|positive regulation of I-kappaB kinase/NF-kappaB cascade	intracellular				central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|urinary_tract(1)	18		all_cancers(87;7.87e-06)|Acute lymphoblastic leukemia(125;3.61e-09)|all_hematologic(75;2.63e-07)|all_epithelial(87;0.0024)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.033)|all cancers(137;0.0412)|Epithelial(106;0.0732)		TGAACTCAATCTGCATCTGAA	0.363000													7	32					1	1	1	1	0
PITX3	5309	broad.mit.edu	37	10	103990642	103990642	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr10:103990642C>T	ENST00000370002.3	-	4	691	c.538G>A	c.(538-540)Ggg>Agg	p.G180R	PITX3_ENST00000539804.1_Missense_Mutation_p.G180R	NM_005029.3	NP_005020.1	O75364	PITX3_HUMAN	paired-like homeodomain 3	180					dopaminergic neuron differentiation|lens morphogenesis in camera-type eye|midbrain development|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(2)|lung(2)	5		Colorectal(252;0.00957)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		GCCAGAGGCCCCACGTTGACC	0.706000													4	13					0	0	1	0	0
ZBTB38	253461	broad.mit.edu	37	3	141161333	141161333	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr3:141161333G>A	ENST00000514251.1	+	4	382	c.103G>A	c.(103-105)Gtc>Atc	p.V35I	ZBTB38_ENST00000441582.2_Missense_Mutation_p.V35I|ZBTB38_ENST00000321464.5_Missense_Mutation_p.V36I			Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	35	BTB.				positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|cervix(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	41						TTTATGCGATGTCACTATCAT	0.433000													39	121					0	0	1	0	0
HOXC13	3229	broad.mit.edu	37	12	54338930	54338930	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr12:54338930G>A	ENST00000243056.3	+	2	1039	c.883G>A	c.(883-885)Gcc>Acc	p.A295T		NM_017410.2	NP_059106.2	P31276	HXC13_HUMAN	homeobox C13	295						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|large_intestine(1)|skin(1)	3						GCGCATCTCCGCCACCACGAA	0.557000			T	NUP98	AML								21	53					0	0	1	0	0
C4BPA	722	broad.mit.edu	37	1	207287558	207287558	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr1:207287558G>T	ENST00000367070.3	+	3	450	c.256G>T	c.(256-258)Gtc>Ttc	p.V86F		NM_000715.3	NP_000706.1	P04003	C4BPA_HUMAN	complement component 4 binding protein, alpha	86	Sushi 1.				complement activation, classical pathway|innate immune response	extracellular region	protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(2)|skin(1)|urinary_tract(2)	28						CCCTGGCTACGTCAGATCCCA	0.428000													3	74					0.004672	0.00502421	1	1	0
MDC1	9656	broad.mit.edu	37	6	30675733	30675733	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:30675733C>G	ENST00000376406.3	-	8	3270	c.2623G>C	c.(2623-2625)Gac>Cac	p.D875H	MDC1-AS1_ENST00000442150.1_RNA|MDC1_ENST00000376405.2_Intron	NM_014641.2	NP_055456.2	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	875				Missing (in Ref. 2; CAH18685).	cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|kidney(1)|ovary(1)	4						CCATTTTTGTCAGATTCTTGT	0.413000								Other conserved DNA damage response genes					53	226					0	0	1	0	0
ASMTL	8623	broad.mit.edu	37	X	1531718	1531718	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chrX:1531718C>A	ENST00000534940.1	-	12	1603	c.1378G>T	c.(1378-1380)Gct>Tct	p.A460S	ASMTL_ENST00000416733.2_Missense_Mutation_p.A442S|ASMTL_ENST00000381317.3_Missense_Mutation_p.A518S|ASMTL-AS1_ENST00000419737.2_RNA|ASMTL-AS1_ENST00000420411.2_RNA|ASMTL_ENST00000381333.4_Missense_Mutation_p.A502S|ASMTL-AS1_ENST00000602357.1_RNA|ASMTL-AS1_ENST00000425740.2_RNA	NM_001173473.1	NP_001166944.1	O95671	ASML_HUMAN	acetylserotonin O-methyltransferase-like	518	ASMT-like.				melatonin biosynthetic process	cytoplasm	acetylserotonin O-methyltransferase activity			NS(1)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(1)|lung(9)|pancreas(1)|soft_tissue(1)	23		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TACAGCTCAGCGCTGGGGAGG	0.572000													32	172					9.04072e-19	1.14784e-18	1	1	0
TNFRSF19	55504	broad.mit.edu	37	13	24243015	24243015	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr13:24243015G>C	ENST00000382263.3	+	9	1208	c.1024G>C	c.(1024-1026)Gaa>Caa	p.E342Q	TNFRSF19_ENST00000248484.4_Missense_Mutation_p.E342Q|TNFRSF19_ENST00000382258.4_Missense_Mutation_p.E342Q|TNFRSF19_ENST00000403372.2_Missense_Mutation_p.E210Q	NM_001204458.1	NP_001191387.1	Q9NS68	TNR19_HUMAN	tumor necrosis factor receptor superfamily, member 19	342					apoptosis|induction of apoptosis|JNK cascade	integral to membrane|mitochondrion	tumor necrosis factor receptor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(4)|liver(2)|lung(5)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	22		all_cancers(29;3.4e-22)|all_epithelial(30;8.75e-19)|all_lung(29;5.09e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00193)|Epithelial(112;0.0137)|OV - Ovarian serous cystadenocarcinoma(117;0.0465)|GBM - Glioblastoma multiforme(144;0.184)|Lung(94;0.19)		TCCAGAACTTGAAAGCTCAAC	0.433000													33	88					0	0	1	0	0
GRIK2	2898	broad.mit.edu	37	6	102337597	102337597	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:102337597T>A	ENST00000369138.1	+	11	2097	c.1607T>A	c.(1606-1608)cTt>cAt	p.L536H	GRIK2_ENST00000413795.1_Missense_Mutation_p.L536H|GRIK2_ENST00000318991.6_Missense_Mutation_p.L536H|GRIK2_ENST00000369137.3_Missense_Mutation_p.L536H|GRIK2_ENST00000369134.4_Missense_Mutation_p.L487H|GRIK2_ENST00000421544.1_Missense_Mutation_p.L536H	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	536					glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	TTTATGACACTTGGAATAAGT	0.453000													27	114					0	0	1	0	0
TNS1	7145	broad.mit.edu	37	2	218700920	218700920	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr2:218700920C>T	ENST00000171887.4	-	18	3099	c.2647G>A	c.(2647-2649)Gag>Aag	p.E883K	TNS1_ENST00000430930.1_Missense_Mutation_p.E883K|TNS1_ENST00000419504.1_Missense_Mutation_p.E883K	NM_022648.4	NP_072174.3	Q9HBL0	TENS1_HUMAN	tensin 1	883						cytoplasm|cytoskeleton|focal adhesion	actin binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(23)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	79		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		GGCTGCTTCTCCCGAGCCTGT	0.577000													14	41					0	0	1	0	0
CADPS2	93664	broad.mit.edu	37	7	122111491	122111491	+	Silent	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr7:122111491G>A	ENST00000334010.7	-	13	2548	c.2127C>T	c.(2125-2127)gtC>gtT	p.V709V	CADPS2_ENST00000412584.2_Silent_p.V705V|CADPS2_ENST00000449022.2_Silent_p.V708V|CADPS2_ENST00000313070.7_Silent_p.V705V	NM_001167940.1	NP_001161412.1	Q86UW7	CAPS2_HUMAN	Ca++-dependent secretion activator 2	708					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(2)	43						TAGGGTCAATGACAGCACCAT	0.453000													8	10					0	0	1	0	0
LRRC16A	55604	broad.mit.edu	37	6	25540226	25540226	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:25540226G>T	ENST00000329474.6	+	26	2616	c.2248G>T	c.(2248-2250)Ggc>Tgc	p.G750C		NM_001173977.1|NM_017640.5	NP_001167448.1|NP_060110.4	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	750					actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				breast(4)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	50						GGGAGCCAGTGGCTTACTATC	0.388000													5	30					0.000157383	0.000176284	1	1	0
EPHA1	2041	broad.mit.edu	37	7	143095086	143095086	+	Silent	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr7:143095086G>A	ENST00000275815.3	-	8	1628	c.1542C>T	c.(1540-1542)gtC>gtT	p.V514V		NM_005232.4	NP_005223.4	P21709	EPHA1_HUMAN	EPH receptor A1	514	Fibronectin type-III 2.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(21)|ovary(4)|skin(1)|stomach(1)|urinary_tract(3)	51	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				TTCGGACTCTGACGATGTATG	0.557000													8	30					0	0	1	0	0
MARCH7	64844	broad.mit.edu	37	2	160604655	160604655	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr2:160604655G>T	ENST00000259050.4	+	5	976	c.854G>T	c.(853-855)cGc>cTc	p.R285L	MARCH7_ENST00000539065.1_Missense_Mutation_p.R229L|MARCH7_ENST00000409175.1_Missense_Mutation_p.R285L|MARCH7_ENST00000409591.1_Missense_Mutation_p.R247L	NM_001282805.1|NM_001282807.1|NM_022826.2	NP_001269734.1|NP_001269736.1|NP_073737.1	Q9H992	MARH7_HUMAN	membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase		Ser-rich.						ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(3)|prostate(1)|skin(1)|stomach(2)	18						TTGCTGTCACGCATAGCTTCT	0.383000													7	95					2.0095e-06	2.35412e-06	1	1	0
C9orf156	51531	broad.mit.edu	37	9	100667175	100667175	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr9:100667175C>A	ENST00000375119.3	-	5	1242	c.1166G>T	c.(1165-1167)cGg>cTg	p.R389L		NM_016481.3	NP_057565.3	Q9BU70	NAP1_HUMAN	chromosome 9 open reading frame 156	389					interspecies interaction between organisms		hydrolase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(3)|prostate(1)|skin(1)	13		Acute lymphoblastic leukemia(62;0.158)				GCAAAGCTTCCGGCGGTACAC	0.517000													17	37					2.35188e-11	2.89508e-11	1	1	0
ANK3	288	broad.mit.edu	37	10	61828623	61828623	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr10:61828623C>G	ENST00000280772.2	-	37	12207	c.12016G>C	c.(12016-12018)Gag>Cag	p.E4006Q	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000355288.2_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)						establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TTTAAGGTCTCACCACTAATT	0.433000													35	114					0	0	1	0	0
SEL1L3	23231	broad.mit.edu	37	4	25835109	25835109	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr4:25835109C>T	ENST00000399878.3	-	4	1065	c.943G>A	c.(943-945)Gag>Aag	p.E315K	SEL1L3_ENST00000264868.5_Missense_Mutation_p.E280K|SEL1L3_ENST00000502949.1_Missense_Mutation_p.E162K|SEL1L3_ENST00000513364.1_5'UTR	NM_015187.3	NP_056002.2	Q68CR1	SE1L3_HUMAN	sel-1 suppressor of lin-12-like 3 (C. elegans)	315						integral to membrane	binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(2)	14						CCGTACATCTCATTAGAGTCA	0.388000													3	37					0	0	1	0	0
KIF1B	23095	broad.mit.edu	37	1	10397460	10397460	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr1:10397460G>C	ENST00000377086.1	+	31	3493	c.3291G>C	c.(3289-3291)aaG>aaC	p.K1097N	KIF1B_ENST00000263934.6_Missense_Mutation_p.K1051N|KIF1B_ENST00000377081.1_Missense_Mutation_p.K1097N			O60333	KIF1B_HUMAN	kinesin family member 1B	1097					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			breast(2)|endometrium(7)|kidney(8)|large_intestine(9)|lung(29)|ovary(3)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(2)	71	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		TGGATGGTAAGATGGTAATGG	0.463000													29	156					0	0	1	0	0
ARHGAP39	80728	broad.mit.edu	37	8	145772682	145772682	+	Silent	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr8:145772682G>A	ENST00000276826.5	-	4	1989	c.1788C>T	c.(1786-1788)ccC>ccT	p.P596P	ARHGAP39_ENST00000540274.1_Silent_p.P596P|ARHGAP39_ENST00000377307.2_Silent_p.P596P			Q9C0H5	RHG39_HUMAN	Rho GTPase activating protein 39	596					axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22						CCACCGGCCCGGGCATGGGCA	0.687000													3	16					0	0	1	0	0
AFG3L2	10939	broad.mit.edu	37	18	12329608	12329608	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr18:12329608C>T	ENST00000269143.3	-	17	2581	c.2350G>A	c.(2350-2352)Gaa>Aaa	p.E784K	TUBB6_ENST00000590967.1_Intron|TUBB6_ENST00000591909.1_3'UTR	NM_006796.2	NP_006787.2	Q9Y4W6	AFG32_HUMAN	AFG3-like AAA ATPase 2	784					cell death|protein catabolic process|proteolysis	integral to membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding			NS(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(12)|prostate(3)|skin(1)|stomach(3)|urinary_tract(1)	27					Adenosine triphosphate(DB00171)	TTCTCCTTTTCCCGCTCCTTG	0.522000													39	40					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	121008405	121008405	+	Missense_Mutation	SNP	G	G	A	rs139732688	by1000genomes	TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr11:121008405G>A	ENST00000392793.1	+	11	3488	c.3217G>A	c.(3217-3219)Gag>Aag	p.E1073K	TECTA_ENST00000264037.2_Missense_Mutation_p.E1073K			O75443	TECTA_HUMAN	tectorin alpha	1073					cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GGTCCACTGCGAGACCATTCC	0.577000													16	41					0	0	1	0	0
GTF3C1	2975	broad.mit.edu	37	16	27518478	27518478	+	Splice_Site	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr16:27518478C>A	ENST00000356183.4	-	9	1258		c.e9-1		GTF3C1_ENST00000561623.1_Splice_Site	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa							transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						CCATGAATCCCTAGAGGGAAT	0.507000													10	92					0.0692343	0.0711412	1	1	0
OR51A4	401666	broad.mit.edu	37	11	4967756	4967756	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr11:4967756G>A	ENST00000380373.2	-	1	600	c.575C>T	c.(574-576)tCt>tTt	p.S192F	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001005329.1	NP_001005329.1	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A, member 4	192					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(15)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCTGTTGTCAGAACAGGCCAA	0.408000													22	36					0	0	1	0	0
DNAJC16	23341	broad.mit.edu	37	1	15888662	15888662	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr1:15888662G>C	ENST00000375847.3	+	9	1344	c.1180G>C	c.(1180-1182)Gag>Cag	p.E394Q	DNAJC16_ENST00000375838.1_Missense_Mutation_p.E394Q|DNAJC16_ENST00000375849.1_Missense_Mutation_p.E394Q|DNAJC16_ENST00000483270.1_3'UTR	NM_015291.2	NP_056106.1	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	394					cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(7)|urinary_tract(1)	18		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		ATTGACTGCTGAGACTACCAA	0.458000													31	200					0	0	1	0	0
SPTAN1	6709	broad.mit.edu	37	9	131375659	131375659	+	Splice_Site	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr9:131375659G>A	ENST00000358161.5	+	40	5156		c.e40-1		SPTAN1_ENST00000372731.4_Splice_Site|SPTAN1_ENST00000372739.3_Splice_Site			Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1						actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			NS(2)|breast(8)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(21)|liver(1)|lung(25)|ovary(5)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	87						TTCATTGCCAGGTGGAGGCCC	0.483000													44	10					0	0	1	0	0
ZNF713	349075	broad.mit.edu	37	7	56007392	56007392	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr7:56007392A>G	ENST00000429591.2	+	4	1024	c.986A>G	c.(985-987)tAt>tGt	p.Y329C	MRPS17_ENST00000426595.1_Intron	NM_182633.1	NP_872439.1	Q8N859	ZN713_HUMAN	zinc finger protein 713	329					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	25	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			GAAAAGCCCTATAAATGTAAT	0.408000													35	73					0	0	1	0	0
CPSF3	51692	broad.mit.edu	37	2	9580668	9580668	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr2:9580668A>G	ENST00000460593.1	+	8	1836	c.698A>G	c.(697-699)tAt>tGt	p.Y233C	CPSF3_ENST00000238112.3_Missense_Mutation_p.Y270C			Q9UKF6	CPSF3_HUMAN	cleavage and polyadenylation specific factor 3, 73kDa	270					histone mRNA 3'-end processing|mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex|ribonucleoprotein complex	5'-3' exonuclease activity|endoribonuclease activity|metal ion binding|protein binding|RNA binding			NS(1)|breast(3)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)	all_cancers(51;2.39e-25)|all_epithelial(98;8.75e-19)|Lung NSC(108;2.38e-06)|Ovarian(717;0.0308)		all cancers(51;2.2e-40)|Epithelial(75;6.71e-35)|OV - Ovarian serous cystadenocarcinoma(76;4.35e-21)|STAD - Stomach adenocarcinoma(1183;0.00644)		CCAATATACTATGCATCATCT	0.383000													23	59					0	0	1	0	0
FCHO1	23149	broad.mit.edu	37	19	17877490	17877490	+	Silent	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr19:17877490G>T	ENST00000594202.1	+	7	486	c.207G>T	c.(205-207)ccG>ccT	p.P69P	FCHO1_ENST00000596951.1_Silent_p.P69P|FCHO1_ENST00000539407.1_Silent_p.P69P|FCHO1_ENST00000600676.1_Silent_p.P69P|FCHO1_ENST00000252771.7_Silent_p.P69P|FCHO1_ENST00000595033.1_Silent_p.P19P|FCHO1_ENST00000389133.4_Silent_p.P69P|FCHO1_ENST00000597512.1_Silent_p.P76P|FCHO1_ENST00000596536.1_Silent_p.P69P	NM_001161357.1	NP_001154829.1	O14526	FCHO1_HUMAN	FCH domain only 1	69	FCH.									NS(2)|breast(1)|large_intestine(6)|liver(1)|lung(12)	22						CCTTCGCCCCGCTCTGGGAGG	0.642000													15	12					6.31663e-08	7.52718e-08	1	1	0
UBR5	51366	broad.mit.edu	37	8	103293664	103293664	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr8:103293664G>C	ENST00000520539.1	-	41	6386	c.5780C>G	c.(5779-5781)tCt>tGt	p.S1927C	UBR5_ENST00000521922.1_Missense_Mutation_p.S1921C|UBR5_ENST00000220959.4_Missense_Mutation_p.S1927C	NM_001282873.1|NM_015902.5	NP_001269802.1|NP_056986.2	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin 5	1927					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			NS(1)|breast(13)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(19)|liver(1)|lung(51)|ovary(6)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	124	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			ATCATTATGAGACCGCATTAG	0.423000													15	92					0	0	1	0	0
CCDC130	81576	broad.mit.edu	37	19	13870024	13870024	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr19:13870024G>A	ENST00000586600.1	+	9	1014	c.511G>A	c.(511-513)Gag>Aag	p.E171K	CCDC130_ENST00000587019.1_3'UTR|CCDC130_ENST00000221554.8_Missense_Mutation_p.E171K			P13994	CC130_HUMAN	coiled-coil domain containing 130	171					response to virus		protein binding			endometrium(2)|kidney(1)|large_intestine(3)|ovary(1)|skin(2)|urinary_tract(1)	10			OV - Ovarian serous cystadenocarcinoma(19;6.02e-23)|Epithelial(5;2.58e-18)			CCACATCCAGGAGGCCCAGAG	0.652000													5	8					0	0	1	0	0
ADAM29	11086	broad.mit.edu	37	4	175898960	175898960	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr4:175898960C>G	ENST00000359240.3	+	5	2954	c.2284C>G	c.(2284-2286)Cct>Gct	p.P762A	RP13-577H12.2_ENST00000507525.1_RNA|ADAM29_ENST00000514159.1_Missense_Mutation_p.P762A|ADAM29_ENST00000404450.4_Missense_Mutation_p.P762A|ADAM29_ENST00000445694.1_Missense_Mutation_p.P762A	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	762	9 X 9 AA approximate repeats.				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		GAGTCAACCTCCTGTGACACC	0.572000													25	102					0	0	1	0	0
FNBP4	23360	broad.mit.edu	37	11	47758272	47758272	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr11:47758272C>T	ENST00000263773.5	-	9	1489	c.1477G>A	c.(1477-1479)Gaa>Aaa	p.E493K	FNBP4_ENST00000534003.1_5'UTR	NM_015308.2	NP_056123.2	Q8N3X1	FNBP4_HUMAN	formin binding protein 4	493										NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(12)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	44						TCTATTTTTTCTGAATTTTCA	0.308000													11	18					0	0	1	0	0
POLN	353497	broad.mit.edu	37	4	2209866	2209866	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr4:2209866C>A	ENST00000511885.2	-	5	915	c.562G>T	c.(562-564)Ggg>Tgg	p.G188W	POLN_ENST00000382865.1_Missense_Mutation_p.G188W|POLN_ENST00000515357.1_5'UTR			Q7Z5Q5	DPOLN_HUMAN	polymerase (DNA directed) nu	188					DNA repair|DNA replication	nucleus	DNA binding|DNA-directed DNA polymerase activity			kidney(6)|large_intestine(5)|liver(1)|lung(8)|ovary(2)|skin(4)|urinary_tract(2)	28			OV - Ovarian serous cystadenocarcinoma(23;0.0955)			CCTGAGTTCCCAGAATTTAGG	0.368000								DNA polymerases (catalytic subunits)					19	79					8.00594e-06	9.31146e-06	1	1	0
EWSR1	2130	broad.mit.edu	37	22	29693903	29693903	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr22:29693903C>T	ENST00000397938.2	+	13	1700	c.1381C>T	c.(1381-1383)Cgt>Tgt	p.R461C	EWSR1_ENST00000331029.7_Missense_Mutation_p.R423C|EWSR1_ENST00000406548.1_Missense_Mutation_p.R460C|EWSR1_ENST00000414183.2_Missense_Mutation_p.R466C|EWSR1_ENST00000332035.6_Missense_Mutation_p.R405C|EWSR1_ENST00000332050.6_Missense_Mutation_p.R388C	NM_001163285.1|NM_001163286.1|NM_005243.3|NM_013986.3	NP_001156757.1|NP_001156758.1|NP_005234.1|NP_053733.2	Q01844	EWS_HUMAN	EWS RNA-binding protein 1	461	Arg/Gly/Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	calmodulin binding|nucleotide binding|RNA binding|zinc ion binding		EWSR1/ATF1(347)|EWSR1/POU5F1(10)|EWSR1/PBX1(3)|EWSR1/DDIT3(45)|EWSR1/FEV(11)|EWSR1/CREB1(44)|EWSR1/SMARCA5(2)|EWSR1/ETV4(6)|EWSR1/ERG(178)|EWSR1/ZNF384(4)|EWSR1/ETV1(7)|EWSR1/FLI1(2569)|EWSR1/NR4A3(146)|EWSR1/SP3(3)|EWSR1/PATZ1(2)|EWSR1/WT1(234)|EWSR1/NFATC2(9)	breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|liver(1)|lung(6)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						TCTGCCACCCCGTGAGGGCAG	0.488000			T	"""FLI1, ERG, ZNF278, NR4A3, FEV, ATF1, ETV1, ETV4, WT1, ZNF384, CREB1, POU5F1,  PBX1"""	"""Ewing sarcoma,  desmoplastic small round cell tumor , ALL, clear cell sarcoma, sarcoma, myoepithelioma"""								11	58					0	0	1	0	0
METTL17	64745	broad.mit.edu	37	14	21460707	21460707	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr14:21460707G>A	ENST00000339374.6	+	5	687	c.454G>A	c.(454-456)Gag>Aag	p.E152K	METTL17_ENST00000382985.4_Missense_Mutation_p.E152K|METTL17_ENST00000556670.2_Missense_Mutation_p.E152K	NM_001029991.1|NM_022734.2	NP_001025162.1|NP_073571.1	Q9H7H0	MET17_HUMAN	methyltransferase like 17	152					translation	mitochondrion|ribosome	copper ion binding|methyltransferase activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|skin(2)	20						CAGCTACACTGAGGGACTGAG	0.433000													8	26					0	0	1	0	0
OR2T3	343173	broad.mit.edu	37	1	248637606	248637606	+	Nonstop_Mutation	SNP	T	T	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr1:248637606T>A	ENST00000359594.2	+	1	980	c.955T>A	c.(955-957)Tag>Aag	p.*319K		NM_001005495.1	NP_001005495.1	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T, member 3	0					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(5)|lung(19)|ovary(1)|prostate(1)|skin(3)	31	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CCAAGAAAAGTAGTAAAGGGC	0.502000													29	103					0	0	1	0	0
KANSL1	284058	broad.mit.edu	37	17	44115978	44115978	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr17:44115978C>A	ENST00000262419.6	-	10	2937	c.2467G>T	c.(2467-2469)Gtg>Ttg	p.V823L	KANSL1_ENST00000572904.1_Missense_Mutation_p.V823L|KANSL1_ENST00000432791.1_Missense_Mutation_p.V823L|KANSL1_ENST00000393476.3_Missense_Mutation_p.V117L|KANSL1_ENST00000574590.1_Missense_Mutation_p.V823L|KANSL1_ENST00000575318.1_Missense_Mutation_p.V760L	NM_001193466.1	NP_001180395	Q7Z3B3	K1267_HUMAN	KAT8 regulatory NSL complex subunit 1	823						MLL1 complex	protein binding										AGCTGTCGCACCAAGGGACTG	0.562000													8	40					1.12685e-05	1.29815e-05	1	1	0
MXRA8	54587	broad.mit.edu	37	1	1290660	1290660	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr1:1290660C>T	ENST00000477278.2	-	4	928	c.415G>A	c.(415-417)Gag>Aag	p.E139K	MXRA8_ENST00000342753.4_Missense_Mutation_p.E47K|MXRA8_ENST00000309212.6_Missense_Mutation_p.E148K|MXRA8_ENST00000445648.2_Missense_Mutation_p.E148K	NM_001282583.1	NP_001269512.1	Q9BRK3	MXRA8_HUMAN	matrix-remodelling associated 8		Ig-like V-type 1.					integral to membrane				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(3)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GCCAGGCTCTCGTAGAGGTGG	0.731000													7	19					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187630782	187630782	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr4:187630782G>A	ENST00000441802.2	-	2	409	c.200C>T	c.(199-201)gCg>gTg	p.A67V		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	67	Cadherin 1.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						TACTTCCCACGCTGGATGTGT	0.448000										HNSCC(5;0.00058)			13	43					0	0	1	0	0
ACTN3	89	broad.mit.edu	37	11	66326739	66326739	+	RNA	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr11:66326739G>C	ENST00000504911.1	-	0	220				ACTN3_ENST00000502692.1_RNA|ACTN3_ENST00000513398.1_RNA																							GCGCGACTACGATTCGGCTTT	0.687000													6	46					0	0	1	0	0
PEX5	5830	broad.mit.edu	37	12	7354882	7354882	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr12:7354882G>T	ENST00000266564.3	+	7	705	c.688G>T	c.(688-690)Gag>Tag	p.E230*	PEX5_ENST00000266563.5_Intron|PEX5_ENST00000412720.2_Nonsense_Mutation_p.E251*|PEX5_ENST00000434354.2_Nonsense_Mutation_p.E245*|PEX5_ENST00000455147.2_Nonsense_Mutation_p.E230*|PEX5_ENST00000545220.1_3'UTR|PEX5_ENST00000420616.2_Nonsense_Mutation_p.E230*	NM_000319.4	NP_000310.2	P50542	PEX5_HUMAN	peroxisomal biogenesis factor 5	230					protein import into peroxisome matrix, translocation|protein targeting to peroxisome|protein tetramerization|protein transport	cytosol|peroxisomal matrix|peroxisomal membrane	peroxisome matrix targeting signal-1 binding|protein C-terminus binding|protein N-terminus binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)	21						GGTGTCCCTGGAGTCCGGTGC	0.577000													8	36					0.0477658	0.0495008	1	1	0
E2F7	144455	broad.mit.edu	37	12	77438507	77438507	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr12:77438507C>T	ENST00000322886.7	-	6	1133	c.898G>A	c.(898-900)Gtc>Atc	p.V300I	E2F7_ENST00000416496.2_Missense_Mutation_p.V300I	NM_203394.2	NP_976328.2	Q96AV8	E2F7_HUMAN	E2F transcription factor 7	300					cell cycle	transcription factor complex	DNA binding|identical protein binding			central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(15)|lung(14)|ovary(3)|upper_aerodigestive_tract(2)	42						GTTTTGGAGACGAGGAACAGC	0.393000													5	126					0	0	1	0	0
CWH43	80157	broad.mit.edu	37	4	49052780	49052780	+	Silent	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr4:49052780C>T	ENST00000226432.4	+	15	2118	c.1935C>T	c.(1933-1935)atC>atT	p.I645I	CWH43_ENST00000513409.1_Silent_p.I618I	NM_025087.2	NP_079363.2	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)	645					GPI anchor biosynthetic process	integral to membrane				cervix(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(26)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43						AATTTAGGATCCCTGATGACC	0.393000													8	64					0	0	1	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18443805	18443805	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr12:18443805C>T	ENST00000433979.1	+	4	894	c.778C>T	c.(778-780)Cat>Tat	p.H260Y	PIK3C2G_ENST00000266497.5_Missense_Mutation_p.H260Y|PIK3C2G_ENST00000536967.1_3'UTR|RERGL_ENST00000541632.1_Intron|PIK3C2G_ENST00000535651.1_Missense_Mutation_p.H260Y|PIK3C2G_ENST00000538779.1_Missense_Mutation_p.H260Y	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	260					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				AGAAAGATATCATGCAGCTGA	0.323000													5	12					0	0	1	0	0
SAMD8	142891	broad.mit.edu	37	10	76910669	76910669	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr10:76910669C>G	ENST00000372687.4	+	2	468	c.383C>G	c.(382-384)tCt>tGt	p.S128C	SAMD8_ENST00000542569.1_Missense_Mutation_p.S128C|SAMD8_ENST00000372690.3_Missense_Mutation_p.S191C			Q96LT4	SAMD8_HUMAN	sterile alpha motif domain containing 8						sphingomyelin biosynthetic process	integral to membrane				NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)	12	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					GACTTGAATTCTGATCAGTAC	0.413000													4	70					0	0	1	0	0
SEMA3G	56920	broad.mit.edu	37	3	52472134	52472134	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr3:52472134C>A	ENST00000231721.2	-	14	1590	c.1591G>T	c.(1591-1593)Gag>Tag	p.E531*		NM_020163.1	NP_064548.1	Q9NS98	SEM3G_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G	531					multicellular organismal development	extracellular region|membrane	receptor activity			kidney(1)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)	18				BRCA - Breast invasive adenocarcinoma(193;1.69e-05)|Kidney(197;0.00173)|KIRC - Kidney renal clear cell carcinoma(197;0.00196)|OV - Ovarian serous cystadenocarcinoma(275;0.0333)		AGGCAGCACTCTGCACAGGCA	0.647000													8	27					5.4927e-09	6.62677e-09	1	1	0
ZNF600	162966	broad.mit.edu	37	19	53270961	53270961	+	Silent	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr19:53270961G>A	ENST00000338230.3	-	3	315	c.48C>T	c.(46-48)atC>atT	p.I16I		NM_198457.2	NP_940859	Q6ZNG1	ZN600_HUMAN	zinc finger protein 600	16					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(4)|large_intestine(9)|liver(1)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	30				OV - Ovarian serous cystadenocarcinoma(262;0.0241)|GBM - Glioblastoma multiforme(134;0.0404)		TCCCTGTGTGGATCACTTCTG	0.363000													45	241					0	0	1	0	0
PCDHGB4	8641	broad.mit.edu	37	5	140769076	140769076	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr5:140769076C>T	ENST00000519479.1	+	1	1625	c.1625C>T	c.(1624-1626)gCg>gTg	p.A542V	PCDHGB2_ENST00000522605.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_003736.2|NM_018925.2|NM_032098.1	NP_003727.1|NP_061748.1|NP_115269.1														endometrium(9)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|prostate(1)|stomach(3)|urinary_tract(2)	37			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCTCAGCGCGAACGTGAGC	0.687000													7	27					0	0	1	0	0
CNTN6	27255	broad.mit.edu	37	3	1445031	1445031	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr3:1445031G>C	ENST00000446702.2	+	23	3643	c.3016G>C	c.(3016-3018)Gaa>Caa	p.E1006Q	CNTN6_ENST00000350110.2_Missense_Mutation_p.E1006Q|CNTN6_ENST00000539053.1_Missense_Mutation_p.E934Q			Q9UQ52	CNTN6_HUMAN	contactin 6	1006					axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		TCAATTCTTAGAACCTAGCAC	0.294000													17	85					0	0	1	0	0
CCL11	6356	broad.mit.edu	37	17	32612857	32612857	+	Silent	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr17:32612857G>T	ENST00000305869.3	+	1	171	c.30G>T	c.(28-30)ctG>ctT	p.L10L		NM_002986.2	NP_002977.1	P51671	CCL11_HUMAN	chemokine (C-C motif) ligand 11	10					cell adhesion|cellular calcium ion homeostasis|immune response|positive regulation of actin filament polymerization|positive regulation of cell migration|positive regulation of endothelial cell proliferation|positive regulation of Rac GTPase activity|protein phosphorylation|response to radiation|response to virus|signal transduction	extracellular space	chemokine activity			breast(1)|lung(1)|prostate(1)	3	Breast(3;0.00224)	Breast(31;0.151)|Ovarian(249;0.17)		BRCA - Breast invasive adenocarcinoma(366;0.155)		TTCTGTGGCTGCTGCTCATAG	0.587000													29	121					9.80776e-20	1.24849e-19	1	1	0
MYH11	4629	broad.mit.edu	37	16	15826424	15826424	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr16:15826424C>G	ENST00000452625.2	-	28	3756	c.3669G>C	c.(3667-3669)aaG>aaC	p.K1223N	MYH11_ENST00000396324.3_Missense_Mutation_p.K1223N|MYH11_ENST00000300036.5_Missense_Mutation_p.K1216N|AF001548.5_ENST00000574212.1_RNA|MYH11_ENST00000576790.2_Missense_Mutation_p.K1216N	NM_001040113.1	NP_001035202.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	1216					axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						GCATTACCCTCTTGAACTGCT	0.493000			T	CBFB	AML								28	65					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123987417	123987417	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr10:123987417G>A	ENST00000369005.1	+	14	8130	c.7790G>A	c.(7789-7791)cGa>cAa	p.R2597Q	TACC2_ENST00000369000.1_Missense_Mutation_p.R297Q|TACC2_ENST00000369004.3_Missense_Mutation_p.R687Q|TACC2_ENST00000369001.1_Missense_Mutation_p.R301Q|TACC2_ENST00000358010.1_Missense_Mutation_p.R743Q|TACC2_ENST00000513429.1_Missense_Mutation_p.R743Q|TACC2_ENST00000334433.3_Missense_Mutation_p.R2597Q|TACC2_ENST00000368999.1_Missense_Mutation_p.R687Q|TACC2_ENST00000515603.1_Missense_Mutation_p.R2552Q|TACC2_ENST00000260733.3_Missense_Mutation_p.R675Q|TACC2_ENST00000515273.1_Missense_Mutation_p.R2601Q|TACC2_ENST00000360561.3_Missense_Mutation_p.R675Q|TACC2_ENST00000453444.2_Missense_Mutation_p.R2601Q	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	2597						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CCTGTCCCACGAGGACTGGCC	0.537000													18	76					0	0	1	0	0
NPHP3	27031	broad.mit.edu	37	3	132440815	132440815	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr3:132440815C>A	ENST00000326682.8	-	1	461	c.385G>T	c.(385-387)Gaa>Taa	p.E129*	NPHP3_ENST00000337331.5_Nonsense_Mutation_p.E129*|NPHP3-AS1_ENST00000489343.1_RNA|NPHP3_ENST00000383282.2_Nonsense_Mutation_p.E129*|NPHP3_ENST00000343113.4_Nonsense_Mutation_p.E129*			Q7Z494	NPHP3_HUMAN	nephronophthisis 3 (adolescent)	129					maintenance of organ identity|negative regulation of canonical Wnt receptor signaling pathway|photoreceptor cell maintenance|regulation of Wnt receptor signaling pathway, planar cell polarity pathway|Wnt receptor signaling pathway	cilium	protein binding			NS(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(15)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						ACCTGCAGTTCGGCCCGCAGC	0.642000													9	17					1.12685e-05	1.29815e-05	1	1	0
TRIOBP	11078	broad.mit.edu	37	22	38120668	38120668	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr22:38120668A>T	ENST00000406386.3	+	7	2360	c.2105A>T	c.(2104-2106)cAa>cTa	p.Q702L		NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	702					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					TCCTGTGCCCAACGGGACGAT	0.582000													13	40					0	0	1	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140711156	140711156	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr5:140711156C>G	ENST00000517417.1	+	1	905	c.905C>G	c.(904-906)tCa>tGa	p.S302*	PCDHGA1_ENST00000378105.3_Nonsense_Mutation_p.S302*	NM_018912.2	NP_061735.1														breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|lung(32)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGAGAAATATCAAATAAAGAA	0.418000													15	33					0	0	1	0	0
FILIP1L	11259	broad.mit.edu	37	3	99568842	99568842	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr3:99568842C>G	ENST00000331335.5	-	5	2148	c.1678G>C	c.(1678-1680)Gta>Cta	p.V560L	FILIP1L_ENST00000476723.1_Intron|CMSS1_ENST00000421999.2_Intron|CMSS1_ENST00000496116.1_Intron|FILIP1L_ENST00000354552.3_Missense_Mutation_p.V560L|FILIP1L_ENST00000471562.1_Missense_Mutation_p.V320L|FILIP1L_ENST00000383694.2_Missense_Mutation_p.V320L|FILIP1L_ENST00000487087.1_Missense_Mutation_p.V136L	NM_001042459.1	NP_001035924.1	Q4L180	FIL1L_HUMAN	filamin A interacting protein 1-like	560						cytoplasm|membrane|myosin complex|nucleus				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	35						TCCTTGGTTACGCTGTACATC	0.358000													10	68					0	0	1	0	0
OR51E1	143503	broad.mit.edu	37	11	4674582	4674582	+	Missense_Mutation	SNP	G	G	A	rs146565220	byFrequency	TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr11:4674582G>A	ENST00000396952.5	+	2	1476	c.826G>A	c.(826-828)Gtc>Atc	p.V276I	OR51E1_ENST00000530215.1_Silent_p.P52P	NM_152430.3	NP_689643.2	Q8TCB6	O51E1_HUMAN	olfactory receptor, family 51, subfamily E, member 1	275					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V275I(1)		NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|pancreas(1)|skin(1)|stomach(2)	30		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;7.37e-14)|GBM - Glioblastoma multiforme(2;2.85e-05)|BRCA - Breast invasive adenocarcinoma(625;0.00222)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCCGCTGCCCGTCATCTTGGC	0.483000													21	33					0	0	1	0	0
EFNA1	1942	broad.mit.edu	37	1	155106431	155106431	+	Splice_Site	SNP	A	A	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr1:155106431A>G	ENST00000368407.3	+	5	1024	c.506A>G	c.(505-507)gAt>gGt	p.D169G	EFNA1_ENST00000469878.1_3'UTR|EFNA1_ENST00000368406.2_Splice_Site_p.D147G	NM_004428.2	NP_004419.2	P20827	EFNA1_HUMAN	ephrin-A1	169					angiogenesis|aortic valve morphogenesis|cell migration|cell-cell signaling|endocardial cushion to mesenchymal transition involved in heart valve formation|ephrin receptor signaling pathway|mitral valve morphogenesis|negative regulation of epithelial to mesenchymal transition|negative regulation of transcription from RNA polymerase II promoter|positive regulation of peptidyl-tyrosine phosphorylation|regulation of cell adhesion mediated by integrin|substrate adhesion-dependent cell spreading	extracellular region|integral to plasma membrane	ephrin receptor binding			breast(1)|endometrium(1)|kidney(1)|lung(1)|skin(1)	5	all_epithelial(22;4.71e-30)|all_lung(78;3.15e-27)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;2.28e-10)|all cancers(21;6.16e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000395)|LUSC - Lung squamous cell carcinoma(543;0.193)			CACCTTGCAGATGACCCAGAG	0.577000													6	8					0	0	1	0	0
HS3ST4	9951	broad.mit.edu	37	16	26147161	26147161	+	Silent	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr16:26147161C>T	ENST00000331351.5	+	2	1355	c.963C>T	c.(961-963)ctC>ctT	p.L321L	HS3ST4_ENST00000475436.1_3'UTR	NM_006040.2	NP_006031.2	Q9Y661	HS3S4_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 4	321					heparan sulfate proteoglycan metabolic process	extracellular region|Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			breast(2)|endometrium(3)|large_intestine(1)|lung(9)	15				GBM - Glioblastoma multiforme(48;0.0988)		ACCGGACCCTCGGGCTGATCG	0.547000													41	201					0	0	1	0	0
RIN2	54453	broad.mit.edu	37	20	19955925	19955925	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr20:19955925G>T	ENST00000255006.6	+	8	1552	c.1403G>T	c.(1402-1404)cGg>cTg	p.R468L	RIN2_ENST00000440354.2_Intron|RIN2_ENST00000484638.1_3'UTR	NM_001242581.1|NM_018993.3	NP_001229510.1|NP_061866.1	Q8WYP3	RIN2_HUMAN	Ras and Rab interactor 2	419					endocytosis|small GTPase mediated signal transduction	cytoplasm	GTPase activator activity|Rab guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|urinary_tract(2)	27						TCTGAATCACGGCCCCCGTGC	0.697000													3	13					6.4e-05	7.26932e-05	1	1	0
DST	667	broad.mit.edu	37	6	56417488	56417488	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:56417488G>A	ENST00000370754.5	-	61	16008	c.16009C>T	c.(16009-16011)Cag>Tag	p.Q5337*	DST_ENST00000361203.3_Nonsense_Mutation_p.Q5157*|DST_ENST00000446842.2_Nonsense_Mutation_p.Q4833*|DST_ENST00000370769.4_Nonsense_Mutation_p.Q5159*|DST_ENST00000421834.2_Nonsense_Mutation_p.Q3071*|DST_ENST00000312431.6_3'UTR|DST_ENST00000244364.6_Nonsense_Mutation_p.Q2745*|DST_ENST00000370788.2_Nonsense_Mutation_p.Q3071*			Q03001	DYST_HUMAN	dystonin	5157					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TCAACCTGCTGACTTAGTGTA	0.428000													12	51					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10222344	10222344	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr17:10222344C>A	ENST00000418404.3	-	26	3664	c.3501G>T	c.(3499-3501)atG>atT	p.M1167I	MYH13_ENST00000252172.4_Missense_Mutation_p.M1167I			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	1167					muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						TCTTCTTGTTCATCTCAATCT	0.582000													54	55					3.76628e-20	4.80697e-20	1	1	0
C10orf32-ASMT	100528007	broad.mit.edu	37	10	104620266	104620266	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr10:104620266G>C	ENST00000299353.6	+	3	231	c.216G>C	c.(214-216)aaG>aaC	p.K72N	C10orf32_ENST00000339834.5_Missense_Mutation_p.K72N|C10orf32_ENST00000369883.3_Missense_Mutation_p.K72N																							GTTTAAGGAAGATGGCAATAA	0.378000													3	69					0	0	1	0	0
DBF4	10926	broad.mit.edu	37	7	87514376	87514376	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr7:87514376G>A	ENST00000265728.1	+	3	806	c.302G>A	c.(301-303)cGa>cAa	p.R101Q		NM_006716.3	NP_006707.1	Q9UBU7	DBF4A_HUMAN	DBF4 homolog (S. cerevisiae)	101	BRCT 1.				cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	enzyme activator activity|nucleic acid binding|protein binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(13)|ovary(1)|skin(3)	28	Esophageal squamous(14;0.00202)	Breast(660;0.0334)				ACCTTGGGTCGAATTTCTCCT	0.388000													8	28					0	0	1	0	0
FGFR3	2261	broad.mit.edu	37	4	1807889	1807889	+	Missense_Mutation	SNP	A	A	G	rs78311289		TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr4:1807889A>G	ENST00000340107.4	+	14	2210	c.1954A>G	c.(1954-1956)Aag>Gag	p.K652E	FGFR3_ENST00000412135.2_Missense_Mutation_p.K538E|FGFR3_ENST00000440486.2_Missense_Mutation_p.K650E|FGFR3_ENST00000260795.2_Missense_Mutation_p.K650E|FGFR3_ENST00000352904.1_Missense_Mutation_p.K538E|FGFR3_ENST00000481110.2_Missense_Mutation_p.K651E	NM_001163213.1	NP_001156685.1	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3	650	Protein kinase.				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.K650E(46)|p.K650Q(5)		NS(1)|central_nervous_system(5)|cervix(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(40)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(9)|skin(339)|soft_tissue(4)|testis(2)|upper_aerodigestive_tract(58)|urinary_tract(2607)	3091		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	CTACTACAAGAAGACGACCAA	0.667000		1	"""Mis, T"""	"""IGH@, ETV6"""	"""bladder, MM, T-cell lymphoma"""		"""Hypochondroplasia, Thanatophoric dysplasia"""		Saethre-Chotzen syndrome;Muenke syndrome				10	14					0	0	1	0	0
DNM1P47	100216544	broad.mit.edu	37	15	102291867	102291867	+	RNA	SNP	G	G	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr15:102291867G>T	ENST00000561463.1	+	0	633																											CAACAAGACCGTGTGGAACCT	0.562000													4	57					2.56e-06	2.99181e-06	1	1	0
TENM3	55714	broad.mit.edu	37	4	183676174	183676174	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr4:183676174G>C	ENST00000511685.1	+	22	4777	c.4654G>C	c.(4654-4656)Gat>Cat	p.D1552H	TENM3_ENST00000502950.1_3'UTR|TENM3_ENST00000406950.2_Missense_Mutation_p.D1552H					teneurin transmembrane protein 3																		CAATGACAATGATATTACTGC	0.408000													10	35					0	0	1	0	0
TSC1	7248	broad.mit.edu	37	9	135772892	135772892	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr9:135772892C>A	ENST00000298552.3	-	21	2952	c.2731G>T	c.(2731-2733)Gaa>Taa	p.E911*	TSC1_ENST00000440111.2_Nonsense_Mutation_p.E911*|TSC1_ENST00000545250.1_Nonsense_Mutation_p.E860*	NM_000368.4|NM_001162426.1|NM_001162427.1	NP_000359.1|NP_001155898.1|NP_001155899.1	Q92574	TSC1_HUMAN	tuberous sclerosis 1	911					activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding	p.?(1)		NS(1)|bone(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(9)|lung(20)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	65				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		GATTCCAGTTCCAAAATCCGT	0.433000			"""D, Mis, N, F, S"""			"""hamartoma, renal cell"""			Tuberous Sclerosis				118	12					2.96273e-59	3.8318e-59	1	1	0
PLEC	5339	broad.mit.edu	37	8	144991704	144991704	+	Silent	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr8:144991704C>T	ENST00000322810.4	-	32	12865	c.12696G>A	c.(12694-12696)acG>acA	p.T4232T	PLEC_ENST00000354589.3_Silent_p.T4095T|PLEC_ENST00000356346.3_Silent_p.T4081T|PLEC_ENST00000436759.2_Silent_p.T4122T|PLEC_ENST00000354958.2_Silent_p.T4073T|PLEC_ENST00000357649.2_Silent_p.T4099T|PLEC_ENST00000398774.2_Silent_p.T4063T|PLEC_ENST00000527096.1_Silent_p.T4118T|PLEC_ENST00000345136.3_Silent_p.T4095T	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	4232	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						GGTTCTCCTCCGTGTTAGGGT	0.602000													18	108					0	0	1	0	0
C1orf106	55765	broad.mit.edu	37	1	200877931	200877931	+	Silent	SNP	T	T	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr1:200877931T>G	ENST00000367342.4	+	7	1103	c.903T>G	c.(901-903)ctT>ctG	p.L301L	C1orf106_ENST00000413687.2_Silent_p.L216L	NM_018265.3	NP_060735.3	Q3KP66	CA106_HUMAN	chromosome 1 open reading frame 106	301	Pro-rich.									endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(2)	21						CCCAAACCCTTGAGGGTCTGC	0.592000													8	60					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	39025833	39025833	+	Silent	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr19:39025833C>T	ENST00000355481.4	+	79	11528	c.11397C>T	c.(11395-11397)ctC>ctT	p.L3799L	RYR1_ENST00000359596.3_Silent_p.L3804L|RYR1_ENST00000360985.3_Silent_p.L3804L	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	3804					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TCTCCATCCTCAATGGAGGCA	0.552000													10	36					0	0	1	0	0
BTG1	694	broad.mit.edu	37	12	92537933	92537933	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr12:92537933T>C	ENST00000256015.3	-	2	800	c.439A>G	c.(439-441)Atc>Gtc	p.I147V		NM_001731.2	NP_001722.1	P62324	BTG1_HUMAN	B-cell translocation gene 1, anti-proliferative	147					cell migration|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of angiogenesis|positive regulation of endothelial cell differentiation|positive regulation of myoblast differentiation|regulation of apoptosis|regulation of transcription, DNA-dependent	cytoplasm|nucleus	kinase binding|transcription cofactor activity			haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(1)|lung(2)	16		Acute lymphoblastic leukemia(6;3.02e-13)|all_hematologic(6;4.32e-09)				TTACAGCTGATTCGGCTGTCT	0.468000			T	MYC	BCLL						OREG0022024	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	53	36					0	0	1	0	0
USF1	7391	broad.mit.edu	37	1	161010081	161010081	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr1:161010081G>A	ENST00000368021.3	-	10	958	c.754C>T	c.(754-756)Cag>Tag	p.Q252*	USF1_ENST00000368020.1_Nonsense_Mutation_p.Q252*|USF1_ENST00000435396.1_Nonsense_Mutation_p.Q193*|USF1_ENST00000368019.1_Nonsense_Mutation_p.Q224*	NM_007122.3	NP_009053.1	P22415	USF1_HUMAN	upstream transcription factor 1	252	Helix-loop-helix motif.				cellular response to insulin stimulus|glucose homeostasis|late viral mRNA transcription|lipid homeostasis|positive regulation of transcription from RNA polymerase II promoter by glucose|response to hypoxia|response to UV	transcription factor complex	bHLH transcription factor binding|histone deacetylase binding|protein heterodimerization activity|protein homodimerization activity|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			central_nervous_system(1)|large_intestine(3)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	9	all_cancers(52;6.73e-18)|Breast(13;0.012)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			CGAAGCTCCTGGATATAATCA	0.463000													24	79					0	0	1	0	0
ADRA2A	150	broad.mit.edu	37	10	112838147	112838147	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr10:112838147C>G	ENST00000280155.2	+	1	1358	c.393C>G	c.(391-393)ttC>ttG	p.F131L		NM_000681.3	NP_000672.3	P08913	ADA2A_HUMAN	adrenoceptor alpha 2A	116					actin cytoskeleton organization|activation of MAPK activity by adrenergic receptor signaling pathway|activation of phospholipase C activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cellular component movement|cellular response to hormone stimulus|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|glucose homeostasis|inhibition of adenylate cyclase activity by adrenergic receptor signaling pathway|intestinal absorption|negative regulation of adrenergic receptor signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cAMP biosynthetic process|negative regulation of epinephrine secretion|negative regulation of insulin secretion involved in cellular response to glucose stimulus|negative regulation of lipid catabolic process|negative regulation of norepinephrine secretion|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cytokine production|positive regulation of membrane protein ectodomain proteolysis|positive regulation of potassium ion transport|positive regulation of wound healing|Rho protein signal transduction	basolateral plasma membrane|cytoplasm|integral to plasma membrane|receptor complex	alpha-1B adrenergic receptor binding|alpha-2C adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|heterotrimeric G-protein binding|norepinephrine binding|protein heterodimerization activity|protein homodimerization activity|protein kinase binding|thioesterase binding	p.F116L(2)		breast(1)|cervix(3)|endometrium(6)|large_intestine(3)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Breast(234;0.0735)|Lung NSC(174;0.238)		Epithelial(162;0.000316)|all cancers(201;0.00501)|BRCA - Breast invasive adenocarcinoma(275;0.118)	Amitriptyline(DB00321)|Amphetamine(DB00182)|Apraclonidine(DB00964)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Brimonidine(DB00484)|Clonidine(DB00575)|Debrisoquin(DB04840)|Dexmedetomidine(DB00633)|Dipivefrin(DB00449)|Epinastine(DB00751)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanabenz(DB00629)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Lofexidine(DB04948)|Methyldopa(DB00968)|Mianserin(DB06148)|Mirtazapine(DB00370)|Norepinephrine(DB00368)|Oxymetazoline(DB00935)|Phentolamine(DB00692)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Tizanidine(DB00697)|Trazodone(DB00656)|Yohimbine(DB01392)	ACGTGCTCTTCTGCACGTCGT	0.622000													10	17					0	0	1	0	0
CNTN6	27255	broad.mit.edu	37	3	1415733	1415733	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr3:1415733G>C	ENST00000446702.2	+	16	2698	c.2071G>C	c.(2071-2073)Gaa>Caa	p.E691Q	CNTN6_ENST00000350110.2_Missense_Mutation_p.E691Q|CNTN6_ENST00000539053.1_Missense_Mutation_p.E619Q			Q9UQ52	CNTN6_HUMAN	contactin 6	691	Fibronectin type-III 1.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		TGAACCATCAGAATTGTTAAG	0.363000													13	81					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22176590	22176590	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr1:22176590C>A	ENST00000374695.3	-	57	7469	c.7390G>T	c.(7390-7392)Gcc>Tcc	p.A2464S	HSPG2_ENST00000430507.1_3'UTR	NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	2464	Ig-like C2-type 10.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	TGGGCATGGGCCTGACCAGCA	0.677000													11	181					0.000978159	0.0010782	1	1	0
ZNF514	84874	broad.mit.edu	37	2	95815296	95815296	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr2:95815296C>A	ENST00000295208.2	-	5	1396	c.934G>T	c.(934-936)Gga>Tga	p.G312*	ZNF514_ENST00000411425.1_Nonsense_Mutation_p.G312*	NM_032788.1	NP_116177.1	Q96K75	ZN514_HUMAN	zinc finger protein 514	312					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(4)|lung(6)|urinary_tract(1)	11						GGCTTTTCTCCAGTATGAGTC	0.433000													21	66					1.50039e-11	1.85635e-11	1	1	0
TRIOBP	11078	broad.mit.edu	37	22	38120676	38120676	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr22:38120676G>A	ENST00000406386.3	+	7	2368	c.2113G>A	c.(2113-2115)Gat>Aat	p.D705N		NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	705					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding	p.D705N(1)		central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					CCAACGGGACGATCCCAGAGC	0.582000													18	41					0	0	1	0	0
AFM	173	broad.mit.edu	37	4	74352694	74352694	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr4:74352694G>C	ENST00000226355.3	+	5	586	c.493G>C	c.(493-495)Gaa>Caa	p.E165Q		NM_001133.2	NP_001124.1	P43652	AFAM_HUMAN	afamin	165	Albumin 1.				vitamin transport		vitamin E binding			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	32	Breast(15;0.00102)		Epithelial(6;5.69e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|all cancers(17;0.000555)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			CTTTTTATATGAAGTTGCCAG	0.408000													23	62					0	0	1	0	0
TIMELESS	8914	broad.mit.edu	37	12	56817597	56817597	+	Silent	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr12:56817597G>C	ENST00000229201.4	-	16	2101	c.1947C>G	c.(1945-1947)ctC>ctG	p.L649L	TIMELESS_ENST00000554616.1_Intron|TIMELESS_ENST00000553532.1_Silent_p.L650L	NM_003920.3	NP_003911.2	Q9UNS1	TIM_HUMAN	timeless circadian clock	650					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin		p.L650L(1)		NS(1)|breast(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(8)|lung(14)|ovary(7)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	49						GTGGAGCAGAGAGGATTTGTT	0.493000													15	63					0	0	1	0	0
PRKCB	5579	broad.mit.edu	37	16	24231400	24231400	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr16:24231400C>G	ENST00000321728.7	+	17	2157	c.1982C>G	c.(1981-1983)tCt>tGt	p.S661C	PRKCB_ENST00000303531.7_3'UTR	NM_212535.2	NP_997700.1	P05771	KPCB_HUMAN	protein kinase C, beta	661	AGC-kinase C-terminal.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			central_nervous_system(3)|large_intestine(1)|lung(2)|ovary(3)	9					Vitamin E(DB00163)	GCTGGCTTCTCTTATACTAAC	0.433000													22	99					0	0	1	0	0
ZNF44	51710	broad.mit.edu	37	19	12384109	12384109	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr19:12384109G>C	ENST00000356109.5	-	5	1223	c.1105C>G	c.(1105-1107)Ctt>Gtt	p.L369V	ZNF44_ENST00000355684.5_Missense_Mutation_p.L321V	NM_001164276.1	NP_001157748.1	P15621	ZNF44_HUMAN	zinc finger protein 44	369					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1		Renal(1328;0.157)		GBM - Glioblastoma multiforme(1328;0.0164)|Lung(535;0.179)		AAGCTTCCAAGATGACAAAAC	0.418000													48	98					0	0	1	0	0
HEATR1	55127	broad.mit.edu	37	1	236767261	236767261	+	Silent	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr1:236767261G>A	ENST00000366582.3	-	2	249	c.135C>T	c.(133-135)ttC>ttT	p.F45F	HEATR1_ENST00000366581.2_Silent_p.F45F|HEATR1_ENST00000366579.1_Silent_p.F45F	NM_018072.5	NP_060542.4	Q9H583	HEAT1_HUMAN	HEAT repeat containing 1	45					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(18)|lung(28)|ovary(3)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	87	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			CACCAATGGCGAAGGCGGTGT	0.443000													11	24					0	0	1	0	0
NPC1	4864	broad.mit.edu	37	18	21119907	21119907	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr18:21119907G>C	ENST00000269228.5	-	18	3217	c.2663C>G	c.(2662-2664)cCt>cGt	p.P888R	NPC1_ENST00000540608.1_5'UTR|NPC1_ENST00000412552.2_Missense_Mutation_p.P570R	NM_000271.4	NP_000262.2	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1	888			P -> S (in NPC1).		autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(10)|lung(13)|ovary(2)|stomach(1)	38	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					AAAGTACACAGGCGGACCCGC	0.502000													25	66					0	0	1	0	0
BMS1P20	96610	broad.mit.edu	37	22	22664115	22664115	+	RNA	SNP	A	A	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr22:22664115A>T	ENST00000426066.1	+	0	638					NR_027293.1																						TGTTTAATTCAGCCTTGGAAG	0.413000													5	56					0	0	1	0	0
ZNF514	84874	broad.mit.edu	37	2	95815295	95815295	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr2:95815295C>A	ENST00000295208.2	-	5	1397	c.935G>T	c.(934-936)gGa>gTa	p.G312V	ZNF514_ENST00000411425.1_Missense_Mutation_p.G312V	NM_032788.1	NP_116177.1	Q96K75	ZN514_HUMAN	zinc finger protein 514	312					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(4)|lung(6)|urinary_tract(1)	11						GGGCTTTTCTCCAGTATGAGT	0.428000													21	65					1.50039e-11	1.85635e-11	1	1	0
DHX34	9704	broad.mit.edu	37	19	47858446	47858446	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr19:47858446C>A	ENST00000328771.4	+	3	1205	c.856C>A	c.(856-858)Ctc>Atc	p.L286I		NM_014681.5	NP_055496.2	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	286	Helicase ATP-binding.					intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(5)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		TGAGCGGCATCTCCACAACGA	0.587000													25	80					1.42536e-11	1.77256e-11	1	1	0
MAP3K13	9175	broad.mit.edu	37	3	185155359	185155359	+	Silent	SNP	G	G	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr3:185155359G>A	ENST00000265026.3	+	3	934	c.600G>A	c.(598-600)caG>caA	p.Q200Q	MAP3K13_ENST00000446828.1_Intron|MAP3K13_ENST00000535426.1_Silent_p.Q56Q|MAP3K13_ENST00000443863.1_Silent_p.Q56Q|MAP3K13_ENST00000424227.1_Silent_p.Q200Q	NM_004721.4	NP_004712.1	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase 13	200	Protein kinase.				activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			NS(1)|biliary_tract(1)|breast(3)|endometrium(3)|kidney(1)|large_intestine(13)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	54	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			TGAGAGAACAGAATGAGACGG	0.468000													49	75					0	0	1	0	0
PHLPP2	23035	broad.mit.edu	37	16	71683666	71683666	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr16:71683666C>G	ENST00000393524.2	-	17	3631	c.2898G>C	c.(2896-2898)ttG>ttC	p.L966F	PHLPP2_ENST00000540628.1_Intron|PHLPP2_ENST00000356272.3_Missense_Mutation_p.L1033F|PHLPP2_ENST00000360429.3_Intron|PHLPP2_ENST00000568954.1_Missense_Mutation_p.L1033F|PHLPP2_ENST00000567016.1_Missense_Mutation_p.L1068F			Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein phosphatase 2	1033	PP2C-like.					cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(7)|lung(15)|ovary(1)|prostate(1)|skin(1)|stomach(1)	37						CACCAATATTCAAATAAACTA	0.498000													9	178					0	0	1	0	0
CUL1	8454	broad.mit.edu	37	7	148451088	148451088	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr7:148451088C>G	ENST00000325222.4	+	3	440	c.161C>G	c.(160-162)aCt>aGt	p.T54S	CUL1_ENST00000602748.1_Missense_Mutation_p.T54S|CUL1_ENST00000409469.1_Missense_Mutation_p.T54S	NM_003592.2	NP_003583.2	Q13616	CUL1_HUMAN	cullin 1	54					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(5)|large_intestine(10)|liver(2)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	40	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			AACTACTGTACTAGTGTTCAC	0.403000													7	26					0	0	1	0	0
MMP3	4314	broad.mit.edu	37	11	102709358	102709358	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr11:102709358C>A	ENST00000299855.5	-	8	1409	c.1153G>T	c.(1153-1155)Gtg>Ttg	p.V385L		NM_002422.3	NP_002413.1	P08254	MMP3_HUMAN	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	385					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	22		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0142)	Marimastat(DB00786)|Simvastatin(DB00641)	ATTTTCCTCACGGTTGGAGGG	0.403000													7	75					0.0293803	0.030644	1	1	0
LRP1B	53353	broad.mit.edu	37	2	141283902	141283902	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr2:141283902C>A	ENST00000389484.3	-	48	8751	c.7780G>T	c.(7780-7782)Gtt>Ttt	p.V2594F		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2594	LDL-receptor class A 13.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CGGAACTCAACCGTGGCACAG	0.388000										TSP Lung(27;0.18)			4	51					0.000602214	0.000665317	1	1	0
PLEC	5339	broad.mit.edu	37	8	145010165	145010165	+	Silent	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr8:145010165C>T	ENST00000322810.4	-	6	1033	c.864G>A	c.(862-864)gtG>gtA	p.V288V	PLEC_ENST00000354589.3_Silent_p.V151V|PLEC_ENST00000356346.3_Silent_p.V137V|PLEC_ENST00000436759.2_Silent_p.V178V|PLEC_ENST00000354958.2_Silent_p.V129V|PLEC_ENST00000357649.2_Silent_p.V155V|PLEC_ENST00000398774.2_Silent_p.V119V|PLEC_ENST00000527096.1_Silent_p.V178V|PLEC_ENST00000345136.3_Silent_p.V151V	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	288	Actin-binding.|Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						ACTGCCCACTCACCTGGATAT	0.622000													7	71					0	0	1	0	0
FBXO5	26271	broad.mit.edu	37	6	153292386	153292386	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:153292386C>G	ENST00000367241.3	-	5	1498	c.1118G>C	c.(1117-1119)tGt>tCt	p.C373S	FBXO5_ENST00000477822.1_5'UTR|FBXO5_ENST00000229758.3_Missense_Mutation_p.C419S	NM_001142522.1	NP_001135994.1	Q9UKT4	FBX5_HUMAN	F-box protein 5	419					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol|nucleoplasm|spindle	metal ion binding|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(3)|prostate(2)|upper_aerodigestive_tract(1)	15		Ovarian(120;0.125)		OV - Ovarian serous cystadenocarcinoma(155;4.38e-10)|BRCA - Breast invasive adenocarcinoma(81;0.0893)		GCCATCTGAACAGTCTTTAGT	0.373000													21	30					0	0	1	0	0
ATR	545	broad.mit.edu	37	3	142259785	142259785	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr3:142259785C>A	ENST00000350721.4	-	18	3663	c.3542G>T	c.(3541-3543)gGc>gTc	p.G1181V	ATR_ENST00000383101.3_Missense_Mutation_p.G1117V	NM_001184.3	NP_001175.2	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related	1181					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity	p.G1181V(1)|p.G1181F(1)		NS(1)|breast(10)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|liver(2)|lung(45)|ovary(3)|skin(10)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(4)	122						GAATCGAAGGCCAGTTCTCAG	0.383000								Other conserved DNA damage response genes					9	32					1.12685e-05	1.29815e-05	1	1	0
EYS	346007	broad.mit.edu	37	6	66204893	66204893	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:66204893A>T	ENST00000503581.1	-	4	948	c.411T>A	c.(409-411)aaT>aaA	p.N137K	EYS_ENST00000342421.5_Missense_Mutation_p.N137K|EYS_ENST00000370621.3_Missense_Mutation_p.N137K|EYS_ENST00000393380.2_Missense_Mutation_p.N137K|EYS_ENST00000370616.2_Missense_Mutation_p.N137K|EYS_ENST00000370618.3_Missense_Mutation_p.N137K	NM_001142800.1	NP_001136272.1	Q5T1H1	EYS_HUMAN	eyes shut homolog (Drosophila)	137					response to stimulus|visual perception	extracellular region	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	69						GCCACTTAGAATTAACAGTGT	0.413000													14	46					0	0	1	0	0
C3orf17	25871	broad.mit.edu	37	3	112732137	112732137	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr3:112732137C>A	ENST00000314400.5	-	4	646	c.455G>T	c.(454-456)tGc>tTc	p.C152F	C3orf17_ENST00000383675.2_Intron|C3orf17_ENST00000393857.2_Missense_Mutation_p.C16F	NM_015412.3	NP_056227.2	Q6NW34	CC017_HUMAN	chromosome 3 open reading frame 17	152						integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(2)|lung(6)|prostate(2)|skin(1)	13						TTTGCAGCAGCAGTCCAACAA	0.388000													20	36					2.37509e-13	2.96123e-13	1	1	0
SP140L	93349	broad.mit.edu	37	2	231223823	231223823	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr2:231223823C>T	ENST00000243810.6	+	4	415	c.415C>T	c.(415-417)Cac>Tac	p.H139Y	SP140L_ENST00000444636.1_Missense_Mutation_p.H139Y|SP140L_ENST00000396563.4_Missense_Mutation_p.H139Y|SP140L_ENST00000415673.2_Missense_Mutation_p.H139Y|SP140L_ENST00000458341.1_Missense_Mutation_p.H52Y			Q9H930	LY10L_HUMAN	SP140 nuclear body protein-like	139	HSR.					nucleus	DNA binding|metal ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(7)|prostate(1)|skin(1)	20						CGATTTAATTCACATTTATAA	0.373000													30	93					0	0	1	0	0
ITPRIPL1	150771	broad.mit.edu	37	2	96992793	96992795	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr2:96992793_96992795delGAG	ENST00000361124.4	+	1	859_861	c.448_450delGAG	c.(448-450)gagdel	p.E155del	ITPRIPL1_ENST00000536814.1_In_Frame_Del_p.E139del|ITPRIPL1_ENST00000439118.2_In_Frame_Del_p.E147del|ITPRIPL1_ENST00000542887.1_In_Frame_Del_p.E139del	NM_178495.5	NP_848590.3	Q6GPH6	IPIL1_HUMAN	inositol 1,4,5-trisphosphate receptor interacting protein-like 1	147						integral to membrane				breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						TTCCAGCAGTGAGGAGGAGGAGG	0.532													7	70	---	---	---	---					
RP11-13J8.1	0	broad.mit.edu	37	2	201967197	201967197	+	RNA	DEL	A	A	-	rs77338628		TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr2:201967197delA	ENST00000448256.1	+	0	607																											actctgtctcaaaaaaaaaaa	0.453													3	4	---	---	---	---					
SETD5	55209	broad.mit.edu	37	3	9488817	9488817	+	Frame_Shift_Del	DEL	G	G	-			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr3:9488817delG	ENST00000402466.1	+	15	2082	c.1314delG	c.(1312-1314)ttgfs	p.L438fs	SETD5_ENST00000406341.1_Frame_Shift_Del_p.L536fs|SETD5_ENST00000302463.6_Frame_Shift_Del_p.L438fs|SETD5_ENST00000402198.1_Frame_Shift_Del_p.L536fs|SETD5_ENST00000407969.1_Frame_Shift_Del_p.L555fs			Q9C0A6	SETD5_HUMAN	SET domain containing 5	536										NS(2)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(3)|prostate(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		ATCAGCCCTTGGAACAGAGCA	0.438													7	154	---	---	---	---					
CDKN1A	1026	broad.mit.edu	37	6	36652071	36652072	+	Frame_Shift_Ins	INS	-	-	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr6:36652071_36652072insG	ENST00000405375.1	+	2	428_429	c.193_194insG	c.(193-195)tggfs	p.W65fs	CDKN1A_ENST00000244741.5_Frame_Shift_Ins_p.W65fs|CDKN1A_ENST00000373711.2_Frame_Shift_Ins_p.W65fs|CDKN1A_ENST00000478800.1_3'UTR|CDKN1A_ENST00000448526.2_Frame_Shift_Ins_p.W99fs	NM_001220778.1	NP_001207707.1	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	65					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|urinary_tract(5)	15						TGACTTCGCCTGGGAGCGTGTG	0.673													11	25	---	---	---	---					
CNOT1	23019	broad.mit.edu	37	16	58572795	58572800	+	In_Frame_Del	DEL	GGCATC	GGCATC	-			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr16:58572795_58572800delGGCATC	ENST00000317147.5	-	36	5343_5348	c.5011_5016delGATGCC	c.(5011-5016)gatgccdel	p.DA1671del	CNOT1_ENST00000245138.4_In_Frame_Del_p.DA522del|CNOT1_ENST00000569240.1_In_Frame_Del_p.DA1666del	NM_001265612.1|NM_016284.4	NP_001252541.1|NP_057368.3	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	1671					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol		p.D1671Y(1)		breast(1)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(24)|lung(25)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	87				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		CACCACTTGTGGCATCTAGTAAGCCC	0.500													21	27	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7578453	7578471	+	Frame_Shift_Del	DEL	GGCGCGGACGCGGGTGCCG	GGCGCGGACGCGGGTGCCG	-	rs139200646		TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr17:7578453_7578471delGGCGCGGACGCGGGTGCCG	ENST00000420246.2	-	5	591_609	c.459_477delCGGCACCCGCGTCCGCGCC	c.(457-477)cccggcacccgcgtccgcgccfs	p.PGTRVRA153fs	TP53_ENST00000455263.2_Frame_Shift_Del_p.PGTRVRA153fs|TP53_ENST00000269305.4_Frame_Shift_Del_p.PGTRVRA153fs|TP53_ENST00000445888.2_Frame_Shift_Del_p.PGTRVRA153fs|TP53_ENST00000359597.4_Frame_Shift_Del_p.PGTRVRA153fs|TP53_ENST00000413465.2_Frame_Shift_Del_p.PGTRVRA153fs	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	153	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		P -> A (in sporadic cancers; somatic mutation).|P -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|P -> H (in a sporadic cancer; somatic mutation).|P -> L (in sporadic cancers; somatic mutation).|P -> R (in a sporadic cancer; somatic mutation).|P -> S (in sporadic cancers; somatic mutation).|P -> T (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V157F(161)|p.R158L(77)|p.R158H(74)|p.G154V(46)|p.A159V(33)|p.R156P(24)|p.T155N(22)|p.A159P(19)|p.R158C(17)|p.T155P(17)|p.R158G(16)|p.T155I(14)|p.G154G(12)|p.R156fs*14(11)|p.V157I(10)|p.R156H(10)|p.T155A(10)|p.G154S(9)|p.R158P(9)|p.V157D(8)|p.A159A(8)|p.R26L(8)|p.R65L(8)|p.0?(8)|p.V157G(7)|p.A159T(7)|p.A159D(7)|p.P153P(7)|p.V157L(6)|p.V25F(6)|p.R158fs*12(6)|p.R158fs*11(6)|p.G154D(6)|p.T150fs*16(6)|p.V64F(6)|p.R158fs(6)|p.R158R(6)|p.V157V(5)|p.A159fs*11(5)|p.R26H(5)|p.R65H(5)|p.P152fs*14(5)|p.?(5)|p.T155T(5)|p.A159S(4)|p.R158_A159insX(4)|p.G154C(4)|p.R156S(3)|p.G61V(3)|p.R156R(3)|p.R156fs*25(3)|p.R156G(3)|p.R156L(3)|p.G154I(3)|p.T155_R156insDSTPPPGT(3)|p.G22V(3)|p.V157fs*13(3)|p.R65fs(2)|p.T155fs*23(2)|p.V157del(2)|p.V157fs*9(2)|p.A27P(2)|p.R26fs(2)|p.R156C(2)|p.P153fs*26(2)|p.G154fs*14(2)|p.R156_I162delRVRAMAI(2)|p.A159fs*21(2)|p.R26G(2)|p.A66P(2)|p.V157fs*24(2)|p.R65G(2)|p.R158_A159delRA(2)|p.P153fs*22(2)|p.V157fs*22(2)|p.G154fs*27(2)|p.T155S(2)|p.T23_R24insDSTPPPGT(1)|p.R156_V157del(1)|p.V157A(1)|p.G154_R156delGTR(1)|p.T155fs*25(1)|p.Q144_G154del11(1)|p.G61C(1)|p.V157_R158delVR(1)|p.T155_A161delTRVRAMA(1)|p.A27V(1)|p.A66V(1)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.R156fs*20(1)|p.R156del(1)|p.R156fs*12(1)|p.R156fs*18(1)|p.T57fs*16(1)|p.R26fs*11(1)|p.D148_T155delDSTPPPGT(1)|p.T62P(1)|p.G154A(1)|p.R156_R158delRVR(1)|p.V157_M160delVRAM(1)|p.T62A(1)|p.S149fs*72(1)|p.T62N(1)|p.T62I(1)|p.P152fs*27(1)|p.R65fs*11(1)|p.T155fs*15(1)|p.Q144fs*16(1)|p.P153_G154insX(1)|p.V157_I162delVRAMAI(1)|p.V157fs*23(1)|p.V157fs*21(1)|p.V157fs*25(1)|p.T62_R63insDSTPPPGT(1)|p.R158F(1)|p.R158fs*24(1)|p.T155fs*26(1)|p.R156_V157insV(1)|p.T23P(1)|p.T23A(1)|p.T23N(1)|p.T23I(1)|p.T155_R156delTR(1)|p.T150_P153delTPPP(1)|p.A159_Q167delAMAIYKQSQ(1)|p.R158fs*8(1)|p.P151_V173del23(1)|p.G22C(1)|p.R156_A161del(1)|p.D148fs*23(1)|p.R158_A159insXX(1)|p.G154fs*22(1)|p.T18fs*16(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGATGGCCATGGCGCGGACGCGGGTGCCGGGCGGGGGTG	0.621		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			12	9	---	---	---	---					
SLPI	6590	broad.mit.edu	37	20	43881730	43881731	+	Frame_Shift_Ins	INS	-	-	G			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr20:43881730_43881731insG	ENST00000338380.2	-	3	326_327	c.306_307insC	c.(304-309)cccaatfs	p.N103fs		NM_003064.2	NP_003055.1	P03973	SLPI_HUMAN	secretory leukocyte peptidase inhibitor	103	Elastase inhibitory domain.|WAP 2.					extracellular region	serine-type endopeptidase inhibitor activity			lung(3)|ovary(1)	4		Myeloproliferative disorder(115;0.0122)				TCACAGAAATTGGGGGGGTTAA	0.535													13	65	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11085913	11085913	+	RNA	DEL	C	C	-			TCGA-ZF-A9RL-01A-11D-A38G-08	TCGA-ZF-A9RL-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1432caf6-3ad9-4f0e-9269-ca42d04f5f18	5be806c8-5c37-485f-9164-c26a647754f4	g.chr21:11085913delC	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		tcaccaccatcaccactacca	0.557													2	4	---	---	---	---