Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ARMC8	25852	broad.mit.edu	37	3	137942280	137942280	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr3:137942280G>A	ENST00000469044.1	+	4	515	c.244G>A	c.(244-246)Gaa>Aaa	p.E82K	ARMC8_ENST00000538260.1_Missense_Mutation_p.E82K|ARMC8_ENST00000358441.2_Missense_Mutation_p.E68K|ARMC8_ENST00000470821.1_Missense_Mutation_p.E82K|ARMC8_ENST00000471453.1_Missense_Mutation_p.E68K|ARMC8_ENST00000461822.1_Missense_Mutation_p.E82K|ARMC8_ENST00000485396.1_Missense_Mutation_p.E40K|ARMC8_ENST00000491704.1_Missense_Mutation_p.E40K|ARMC8_ENST00000489213.1_Missense_Mutation_p.E40K|ARMC8_ENST00000481646.1_Missense_Mutation_p.E68K|ARMC8_ENST00000393058.3_Missense_Mutation_p.E72K	NM_001267041.1|NM_001267042.1	NP_001253970.1|NP_001253971.1	Q8IUR7	ARMC8_HUMAN	armadillo repeat containing 8	82							binding			endometrium(2)|kidney(1)|large_intestine(7)|lung(5)|upper_aerodigestive_tract(1)	16						GCTGAAAACTGAATGTGCAGT	0.383000													22	50					0	0	1	0	0
NMRK2	27231	broad.mit.edu	37	19	3938638	3938638	+	Silent	SNP	C	C	T	rs142817100		TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr19:3938638C>T	ENST00000168977.2	+	5	494	c.204C>T	c.(202-204)acC>acT	p.T68T	NMRK2_ENST00000593949.1_Silent_p.T73T|NMRK2_ENST00000599576.1_Silent_p.T59T	NM_170678.2	NP_733778.1			nicotinamide riboside kinase 2																		TGCTGGACACCGTGCAGGCCT	0.667000													4	18					0	0	1	0	0
ZMYM3	9203	broad.mit.edu	37	X	70465902	70465902	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chrX:70465902G>C	ENST00000373998.1	-	16	3280	c.2583C>G	c.(2581-2583)atC>atG	p.I861M	ZMYM3_ENST00000373988.1_Missense_Mutation_p.I875M|ZMYM3_ENST00000314425.5_Missense_Mutation_p.I873M|ZMYM3_ENST00000353904.2_Missense_Mutation_p.I873M|ZMYM3_ENST00000489332.1_5'UTR|ZMYM3_ENST00000373984.3_Missense_Mutation_p.I875M	NM_001171162.1	NP_001164633.1	Q14202	ZMYM3_HUMAN	zinc finger, MYM-type 3	873					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(7)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(17)|ovary(1)|prostate(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(35;0.156)					CTGGCACGAAGATGGGCACTG	0.572000													30	13					0	0	1	0	0
MBD4	8930	broad.mit.edu	37	3	129155374	129155374	+	Silent	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr3:129155374C>T	ENST00000429544.2	-	3	1308	c.1113G>A	c.(1111-1113)ttG>ttA	p.L371L	MBD4_ENST00000509587.1_Intron|MBD4_ENST00000393278.2_Intron|MBD4_ENST00000249910.1_Silent_p.L371L|MBD4_ENST00000503197.1_Silent_p.L371L|MBD4_ENST00000507208.1_Silent_p.L371L	NM_001276270.1	NP_001263199.1	O95243	MBD4_HUMAN	methyl-CpG binding domain protein 4	371					depyrimidination	nucleoplasm	DNA N-glycosylase activity|endodeoxyribonuclease activity|protein binding|satellite DNA binding			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)	22						TGTCAGTATGCAAATGTTCTT	0.393000								Base excision repair (BER), DNA glycosylases					52	85					0	0	1	0	0
ZNF883	169834	broad.mit.edu	37	9	115760540	115760540	+	RNA	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr9:115760540C>T	ENST00000427548.1	-	0	1273							P0CG24	ZN883_HUMAN	zinc finger protein 883						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding										CAGATTCCATCAGTACTGAAC	0.358000													23	35					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56443517	56443517	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr19:56443517C>T	ENST00000588751.1	-	1	185	c.161G>A	c.(160-162)cGt>cAt	p.R54H	NLRP13_ENST00000342929.3_Missense_Mutation_p.R54H			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	54	DAPIN.						ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		CCAGGGGATACGCGGGAAGTG	0.557000													4	139					0	0	1	0	0
SLC26A7	115111	broad.mit.edu	37	8	92352742	92352742	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr8:92352742C>G	ENST00000276609.3	+	8	1228	c.989C>G	c.(988-990)tCt>tGt	p.S330C	SLC26A7_ENST00000309536.2_Missense_Mutation_p.S330C|SLC26A7_ENST00000523719.1_Missense_Mutation_p.S330C	NM_001282356.1|NM_052832.2	NP_001269285.1|NP_439897.1	Q8TE54	S26A7_HUMAN	solute carrier family 26 (anion exchanger), member 7	330						basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|large_intestine(10)|lung(26)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	50			BRCA - Breast invasive adenocarcinoma(11;0.00802)			GCTCAAGGATCTGCCAAAAAA	0.512000													19	70					0	0	1	0	0
SLC2A11	66035	broad.mit.edu	37	22	24226968	24226968	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr22:24226968A>G	ENST00000345044.6	+	12	1691	c.1423A>G	c.(1423-1425)Aac>Gac	p.N475D	SLC2A11_ENST00000398356.2_Missense_Mutation_p.N482D|AP000350.10_ENST00000433835.3_Intron|SLC2A11_ENST00000316185.8_Missense_Mutation_p.N478D			Q9BYW1	GTR11_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 11	475						integral to membrane|plasma membrane	sugar transmembrane transporter activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(2)	12						ACACAGACTCAACTTCCCCAG	0.572000													30	59					0	0	1	0	0
MPZL1	9019	broad.mit.edu	37	1	167741688	167741688	+	Silent	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr1:167741688C>T	ENST00000359523.2	+	3	637	c.435C>T	c.(433-435)gtC>gtT	p.V145V	MPZL1_ENST00000392121.3_Intron|MPZL1_ENST00000474859.1_Silent_p.V145V	NM_003953.5|NM_024569.4	NP_003944.1|NP_078845.3	O95297	MPZL1_HUMAN	myelin protein zero-like 1	145	Ig-like V-type.				cell-cell signaling|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	protein binding|structural molecule activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(2)	15	all_hematologic(923;0.215)					ACATCGTTGTCCAGCCTGGAC	0.388000													27	55					0	0	1	0	0
PDCD1	5133	broad.mit.edu	37	2	242793386	242793386	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr2:242793386G>A	ENST00000334409.5	-	5	760	c.691C>T	c.(691-693)Cga>Tga	p.R231*		NM_005018.2	NP_005009.2	Q15116	PDCD1_HUMAN	programmed cell death 1	231					apoptosis|humoral immune response|multicellular organismal development|T cell costimulation	integral to membrane	protein tyrosine phosphatase activity|signal transducer activity			endometrium(1)|lung(2)|ovary(1)|prostate(3)|skin(1)	8		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;3.84e-33)|all cancers(36;8.08e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.41e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0219)		GTCTTCTCTCGCCACTGGAAA	0.627000													16	26					0	0	1	0	0
TAS1R2	80834	broad.mit.edu	37	1	19166532	19166532	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr1:19166532A>C	ENST00000375371.3	-	6	2102	c.2081T>G	c.(2080-2082)gTa>gGa	p.V694G		NM_152232.2	NP_689418.2	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2	694					detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(10)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(3)|stomach(1)	45		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	CATGCCAATTACCACAATGAC	0.572000													43	96					0	0	1	0	0
IRF3	3661	broad.mit.edu	37	19	50163073	50163073	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr19:50163073G>C	ENST00000600911.1	-	6	1392	c.1000C>G	c.(1000-1002)Cag>Gag	p.Q334E	IRF3_ENST00000377139.3_Silent_p.L372L|IRF3_ENST00000600022.1_Silent_p.L99L|IRF3_ENST00000599144.1_Silent_p.L226L|IRF3_ENST00000597198.1_Silent_p.L372L|IRF3_ENST00000596822.1_Missense_Mutation_p.Q61E|IRF3_ENST00000309877.7_Silent_p.L372L|IRF3_ENST00000599223.1_Silent_p.L245L|IRF3_ENST00000599680.1_5'UTR|IRF3_ENST00000601291.1_Missense_Mutation_p.Q378E|IRF3_ENST00000377135.4_Silent_p.L245L|IRF3_ENST00000593922.1_Silent_p.L226L|IRF3_ENST00000598808.1_Silent_p.L226L|IRF3_ENST00000596765.1_Silent_p.L99L			Q14653	IRF3_HUMAN	interferon regulatory factor 3	334	Involved in HERC5 binding.				interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|response to virus|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|endosome membrane|nucleoplasm|plasma membrane	DNA binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			breast(1)|large_intestine(2)|lung(4)|ovary(2)|stomach(1)	10		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.02)		CCAAGGCCCTGAGGCACGTGG	0.607000													18	23					0	0	1	0	0
MTTP	4547	broad.mit.edu	37	4	100518266	100518266	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr4:100518266G>C	ENST00000457717.1	+	9	1208	c.952G>C	c.(952-954)Gac>Cac	p.D318H	RP11-766F14.1_ENST00000508578.1_RNA|MTTP_ENST00000265517.5_Missense_Mutation_p.D318H|MTTP_ENST00000511045.1_Missense_Mutation_p.D345H	NM_000253.2	NP_000244.2	P55157	MTP_HUMAN	microsomal triglyceride transfer protein	318	Vitellogenin.				lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(14)|lung(19)|ovary(4)|prostate(5)|skin(1)|urinary_tract(1)	57				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	CCTGCAGCCTGACAACCTTTC	0.488000													38	76					0	0	1	0	0
RHCE	6006	broad.mit.edu	37	1	25717278	25717278	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr1:25717278C>T	ENST00000349320.3	-	7	1103	c.715G>A	c.(715-717)Ggg>Agg	p.G239R	RHCE_ENST00000243186.6_Missense_Mutation_p.G255R|RHCE_ENST00000346452.4_Intron|RHCE_ENST00000455194.1_Intron|RHCE_ENST00000413854.1_Missense_Mutation_p.G255R|RHCE_ENST00000374352.2_Missense_Mutation_p.G239R|RHCE_ENST00000349438.4_Missense_Mutation_p.G255R|RHCE_ENST00000425135.1_Missense_Mutation_p.G255R|RHCE_ENST00000294413.7_Missense_Mutation_p.G255R|RHCE_ENST00000340849.4_Intron			P18577	RHCE_HUMAN	Rh blood group, CcEe antigens	255						integral to plasma membrane				endometrium(8)|large_intestine(6)|lung(3)	17		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0426)|OV - Ovarian serous cystadenocarcinoma(117;2.12e-27)|Colorectal(126;3.16e-08)|COAD - Colon adenocarcinoma(152;1.72e-06)|STAD - Stomach adenocarcinoma(196;0.00035)|KIRC - Kidney renal clear cell carcinoma(1967;0.000769)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|GBM - Glioblastoma multiforme(114;0.00458)|READ - Rectum adenocarcinoma(331;0.0649)		AAGGATGACCCTGAGATGGCT	0.512000													26	84					0	0	1	0	0
APOBEC4	403314	broad.mit.edu	37	1	183617264	183617264	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr1:183617264C>G	ENST00000308641.4	-	2	924	c.653G>C	c.(652-654)aGa>aCa	p.R218T	APOBEC4_ENST00000481562.1_Intron|RGL1_ENST00000536277.1_Intron|RGL1_ENST00000304685.4_Intron	NM_203454.2	NP_982279.1	Q8WW27	ABEC4_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)	218					mRNA processing		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|zinc ion binding			NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(6)|skin(1)	21						AGCCAGTGCTCTCCCAGTTAA	0.433000													35	58					0	0	1	0	0
WDR17	116966	broad.mit.edu	37	4	177081163	177081163	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr4:177081163C>G	ENST00000393643.2	+	19	2796	c.2544C>G	c.(2542-2544)atC>atG	p.I848M	WDR17_ENST00000508596.1_Missense_Mutation_p.I848M|WDR17_ENST00000507824.2_Missense_Mutation_p.I855M|WDR17_ENST00000280190.4_Missense_Mutation_p.I872M	NM_170710.4	NP_733828.2	Q8IZU2	WDR17_HUMAN	WD repeat domain 17	872										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(18)|lung(46)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	92		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		ACCAATTAATCCAGGAAGATA	0.338000													11	30					0	0	1	0	0
UQCRC2	7385	broad.mit.edu	37	16	21985275	21985275	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr16:21985275C>T	ENST00000268379.4	+	11	1789	c.1025C>T	c.(1024-1026)tCc>tTc	p.S342F	UQCRC2_ENST00000561553.1_Missense_Mutation_p.S342F	NM_003366.2	NP_003357.2	P22695	QCR2_HUMAN	ubiquinol-cytochrome c reductase core protein II	342					aerobic respiration|oxidative phosphorylation|proteolysis|respiratory electron transport chain|transport		metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(5)|lung(4)|prostate(1)|skin(1)	15				GBM - Glioblastoma multiforme(48;0.0264)		TATACTATCTCCCAGGCCACA	0.393000													23	51					0	0	1	0	0
ZNF521	25925	broad.mit.edu	37	18	22805058	22805058	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr18:22805058C>T	ENST00000361524.3	-	4	2972	c.2824G>A	c.(2824-2826)Gaa>Aaa	p.E942K	ZNF521_ENST00000584787.1_Missense_Mutation_p.E722K|ZNF521_ENST00000538137.2_Missense_Mutation_p.E942K	NM_015461.2	NP_056276.1	Q96K83	ZN521_HUMAN	zinc finger protein 521	942					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(21)|lung(97)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	149	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					AGGCCATTTTCGGAGAAGAAG	0.488000			T	PAX5	ALL								42	82					0	0	1	0	0
MAP9	79884	broad.mit.edu	37	4	156281471	156281471	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr4:156281471T>A	ENST00000311277.4	-	7	1162	c.899A>T	c.(898-900)gAg>gTg	p.E300V	AC097467.2_ENST00000609716.1_RNA|AC097467.2_ENST00000609254.1_RNA|AC097467.2_ENST00000598890.1_RNA|AC097467.2_ENST00000417474.1_RNA|AC097467.2_ENST00000600928.1_RNA|AC097467.2_ENST00000608406.1_RNA|AC097467.2_ENST00000594492.1_RNA|AC097467.2_ENST00000594666.1_RNA|AC097467.2_ENST00000597831.1_RNA|AC097467.2_ENST00000596165.1_RNA|MAP9_ENST00000515654.1_Missense_Mutation_p.E276V|AC097467.2_ENST00000596754.1_RNA|AC097467.2_ENST00000598252.1_RNA	NM_001039580.1	NP_001034669.1	Q49MG5	MAP9_HUMAN	microtubule-associated protein 9	300					cell division|mitosis	cytoplasm|microtubule|spindle				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	26	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.143)		CTTGGATTTCTCAACTGCAGT	0.368000													21	54					0	0	1	0	0
PCDH8	5100	broad.mit.edu	37	13	53420940	53420940	+	Silent	SNP	G	G	A			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr13:53420940G>A	ENST00000377942.3	-	1	1835	c.1632C>T	c.(1630-1632)gcC>gcT	p.A544A	PCDH8_ENST00000338862.4_Silent_p.A544A	NM_002590.3	NP_002581.2	O95206	PCDH8_HUMAN	protocadherin 8	544	Cadherin 5.				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(23)|ovary(1)|skin(1)|urinary_tract(1)	36		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		CGGCGCCCCCGGCGCGGCCCA	0.716000													4	3					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237947781	237947781	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr1:237947781C>T	ENST00000366574.2	+	90	13086	c.12769C>T	c.(12769-12771)Cga>Tga	p.R4257*	RYR2_ENST00000360064.6_Nonsense_Mutation_p.R4263*|RYR2_ENST00000542537.1_Nonsense_Mutation_p.R4241*|RYR2_ENST00000609119.1_3'UTR	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4257					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GACCCTTATGCGAATGCTCAG	0.502000													12	20					0	0	1	0	0
CCAR1	55749	broad.mit.edu	37	10	70547732	70547732	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr10:70547732C>T	ENST00000265872.6	+	22	3048	c.2929C>T	c.(2929-2931)Cgg>Tgg	p.R977W	CCAR1_ENST00000543719.1_Missense_Mutation_p.R962W|CCAR1_ENST00000535016.1_Missense_Mutation_p.R962W	NM_001282959.1|NM_001282960.1|NM_018237.2	NP_001269888.1|NP_001269889.1|NP_060707.2	Q8IX12	CCAR1_HUMAN	cell division cycle and apoptosis regulator 1	977					apoptosis|cell cycle|nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm|perinuclear region of cytoplasm	calcium ion binding|nucleic acid binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|lung(13)|ovary(7)|skin(3)	56						TTGCTTTTACCGGAAATTAAC	0.343000													12	42					0	0	1	0	0
OR4D2	124538	broad.mit.edu	37	17	56247787	56247787	+	Silent	SNP	C	C	G			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr17:56247787C>G	ENST00000545221.1	+	1	771	c.771C>G	c.(769-771)ctC>ctG	p.L257L		NM_001004707.3	NP_001004707.1	P58180	OR4D2_HUMAN	olfactory receptor, family 4, subfamily D, member 2	257					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(1)|lung(19)|ovary(1)|skin(2)|stomach(1)	26						GCATTTACCTCTATGCCCGGC	0.542000													38	80					0	0	1	0	0
LMAN1L	79748	broad.mit.edu	37	15	75109019	75109019	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr15:75109019C>T	ENST00000309664.5	+	4	624	c.485C>T	c.(484-486)tCt>tTt	p.S162F	LMAN1L_ENST00000379709.3_Missense_Mutation_p.S162F	NM_021819.2	NP_068591.2	Q9HAT1	LMA1L_HUMAN	lectin, mannose-binding, 1 like	162	L-type lectin-like.					ER-Golgi intermediate compartment membrane|integral to membrane	sugar binding			NS(2)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						CACATCCCCTCTGAGCAGCCT	0.677000													17	36					0	0	1	0	0
PF4V1	5197	broad.mit.edu	37	4	74719571	74719571	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr4:74719571A>T	ENST00000226524.3	+	2	346	c.172A>T	c.(172-174)Atc>Ttc	p.I58F		NM_002620.2	NP_002611.1	P10720	PF4V_HUMAN	platelet factor 4 variant 1	58					immune response	extracellular region	chemokine activity|heparin binding			endometrium(1)|liver(2)	3	Breast(15;0.00102)		all cancers(17;0.00176)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)			TCCCAGGCACATCACCAGCCT	0.612000													11	19					0	0	1	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5239831	5239831	+	Silent	SNP	G	G	A			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr5:5239831G>A	ENST00000274181.7	+	16	2454	c.2316G>A	c.(2314-2316)cgG>cgA	p.R772R		NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16	772	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						CTGGAGCCCGGAGTATCCGCA	0.473000													39	99					0	0	1	0	0
KIAA1683	80726	broad.mit.edu	37	19	18378153	18378153	+	Missense_Mutation	SNP	G	G	A	rs140481493		TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr19:18378153G>A	ENST00000392413.4	-	3	412	c.197C>T	c.(196-198)cCg>cTg	p.P66L	KIAA1683_ENST00000600359.3_Missense_Mutation_p.P20L|KIAA1683_ENST00000600328.3_Missense_Mutation_p.P66L	NM_001145304.1	NP_001138776.1	Q9H0B3	K1683_HUMAN	KIAA1683							mitochondrion				breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						AGGCTGTTGCGGAAGATGCTC	0.642000													31	57					0	0	1	0	0
ISG15	9636	broad.mit.edu	37	1	949846	949846	+	Silent	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr1:949846C>T	ENST00000379389.4	+	2	637	c.486C>T	c.(484-486)ggC>ggT	p.G162G		NM_005101.3	NP_005092.1	P05161	ISG15_HUMAN	ISG15 ubiquitin-like modifier	162					cell-cell signaling|interspecies interaction between organisms|ISG15-protein conjugation|negative regulation of type I interferon production|response to virus|type I interferon-mediated signaling pathway	cytosol|extracellular space	protein binding			endometrium(1)|lung(1)|upper_aerodigestive_tract(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;4.05e-38)|OV - Ovarian serous cystadenocarcinoma(86;4.54e-23)|Colorectal(212;5.37e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00238)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		CAGAGCCTGGCGGGCGGAGCT	0.637000													15	34					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117723945	117723945	+	Silent	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr12:117723945C>T	ENST00000317775.6	-	6	1939	c.1254G>A	c.(1252-1254)tcG>tcA	p.S418S	NOS1_ENST00000338101.4_Silent_p.S418S|NOS1_ENST00000344089.3_3'UTR	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	418					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	CCACACAGCGCGAGGCATTCC	0.562000													25	90					0	0	1	0	0
GRM7	2917	broad.mit.edu	37	3	7503307	7503307	+	Silent	SNP	G	G	C			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr3:7503307G>C	ENST00000486284.1	+	7	1687	c.1413G>C	c.(1411-1413)ggG>ggC	p.G471G	GRM7_ENST00000402647.2_Silent_p.G471G|GRM7_ENST00000458641.2_3'UTR|GRM7_ENST00000389336.4_Silent_p.G471G|GRM7_ENST00000357716.4_Silent_p.G471G|GRM7_ENST00000403881.1_Silent_p.G471G	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	471					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	ACAAGAACGGGGATGCACCTG	0.453000													8	136					0	0	1	0	0
AFF3	3899	broad.mit.edu	37	2	100360567	100360567	+	Splice_Site	SNP	T	T	G			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr2:100360567T>G	ENST00000409236.2	-	8	1150	c.1038A>C	c.(1036-1038)ccA>ccC	p.P346P	AFF3_ENST00000356421.2_Splice_Site_p.P371P|AFF3_ENST00000409579.1_Splice_Site_p.P371P|AFF3_ENST00000317233.4_Splice_Site_p.P346P			P51826	AFF3_HUMAN	AF4/FMR2 family, member 3						multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						CTTTCTTACTTGGATTATTGT	0.433000													25	59					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124392379	124392379	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr10:124392379C>G	ENST00000338354.3	+	48	6089	c.5983C>G	c.(5983-5985)Cct>Gct	p.P1995A	DMBT1_ENST00000330163.4_Missense_Mutation_p.P1367A|DMBT1_ENST00000368956.2_Missense_Mutation_p.P1367A|DMBT1_ENST00000359586.6_Missense_Mutation_p.P715A|DMBT1_ENST00000368955.3_Missense_Mutation_p.P1985A|DMBT1_ENST00000368909.3_Missense_Mutation_p.P1995A|DMBT1_ENST00000344338.3_Missense_Mutation_p.P1985A			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	1995					epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GTCAACAGCTCCTTTTCTCAA	0.498000													9	12					0	0	1	0	0
TRPC6	7225	broad.mit.edu	37	11	101454132	101454132	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr11:101454132C>G	ENST00000344327.3	-	1	527	c.103G>C	c.(103-105)Gac>Cac	p.D35H	TRPC6_ENST00000348423.4_Missense_Mutation_p.D35H|TRPC6_ENST00000532133.1_Missense_Mutation_p.D35H|TRPC6_ENST00000526713.1_Intron|TRPC6_ENST00000360497.4_Missense_Mutation_p.D35H	NM_004621.5	NP_004612.2	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel, subfamily C, member 6	35					axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(14)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		AGCTCCGAGTCCATGAGCAGA	0.726000													5	10					0	0	1	0	0
RORA	6095	broad.mit.edu	37	15	60803787	60803787	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr15:60803787C>G	ENST00000335670.6	-	5	558	c.458G>C	c.(457-459)aGa>aCa	p.R153T	RORA_ENST00000309157.4_Missense_Mutation_p.R178T|RP11-219B17.1_ENST00000558140.1_RNA|RP11-219B17.1_ENST00000559824.1_RNA|RP11-219B17.1_ENST00000559902.1_RNA|RORA_ENST00000449337.2_Missense_Mutation_p.R98T|RP11-219B17.1_ENST00000501579.2_RNA|RORA_ENST00000261523.5_Missense_Mutation_p.R186T|RORA_ENST00000560004.1_5'UTR|RP11-219B17.1_ENST00000558235.1_RNA	NM_134261.2	NP_599023.1	P35398	RORA_HUMAN	RAR-related orphan receptor A	186					positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	21						CAAGCTGTCTCTCTGCTTTTT	0.502000													19	37					0	0	1	0	0
KIAA1715	80856	broad.mit.edu	37	2	176860340	176860340	+	Translation_Start_Site	SNP	G	G	C			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr2:176860340G>C	ENST00000272748.4	-	0	220				KIAA1715_ENST00000466445.1_5'UTR|KIAA1715_ENST00000544803.1_De_novo_Start_InFrame|KIAA1715_ENST00000535310.1_De_novo_Start_InFrame	NM_030650.1	NP_085153.1	Q9C0E8	LNP_HUMAN	KIAA1715							integral to membrane	protein binding			endometrium(1)|large_intestine(4)|lung(12)|ovary(2)|skin(1)	20			OV - Ovarian serous cystadenocarcinoma(117;0.0793)			TGGGCACAATGATAAATATCA	0.328000													17	32					0	0	1	0	0
RPAP1	26015	broad.mit.edu	37	15	41812852	41812852	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr15:41812852G>C	ENST00000304330.4	-	22	3648	c.3532C>G	c.(3532-3534)Ctg>Gtg	p.L1178V	RPAP1_ENST00000561603.1_Intron	NM_015540.2	NP_056355.2	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	1178	Leu-rich.					nucleus	DNA binding|DNA-directed RNA polymerase activity			NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(16)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	45		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		GCTGCCACCAGATGCTGTACT	0.632000													26	52					0	0	1	0	0
CDK18	5129	broad.mit.edu	37	1	205496927	205496927	+	Silent	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr1:205496927C>T	ENST00000360066.2	+	9	1036	c.735C>T	c.(733-735)ttC>ttT	p.F245F	CDK18_ENST00000509056.1_3'UTR|CDK18_ENST00000429964.2_Silent_p.F245F|CDK18_ENST00000506784.1_Silent_p.F275F	NM_002596.3|NM_212502.2|NM_212503.2	NP_002587.2|NP_997667.1|NP_997668.1	Q07002	CDK18_HUMAN	cyclin-dependent kinase 18	243	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity|protein binding|signal transducer activity			breast(2)|endometrium(2)|large_intestine(2)|lung(10)|stomach(2)|urinary_tract(1)	19						CCCAGATTTTCATGTTCCAGC	0.637000													33	79					0	0	1	0	0
EXOSC9	5393	broad.mit.edu	37	4	122723856	122723856	+	Silent	SNP	T	T	G			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr4:122723856T>G	ENST00000512454.1	+	2	357	c.141T>G	c.(139-141)ctT>ctG	p.L47L	EXOSC9_ENST00000243498.5_Silent_p.L63L|EXOSC9_ENST00000509980.1_3'UTR|EXOSC9_ENST00000379663.3_Silent_p.L63L			Q06265	EXOS9_HUMAN	exosome component 9	63	ARE binding.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|immune response|nuclear mRNA surveillance|nuclear polyadenylation-dependent rRNA catabolic process|positive regulation of cell growth|rRNA processing	cytosol|nuclear exosome (RNase complex)|nucleolus|nucleus	3'-5'-exoribonuclease activity|AU-rich element binding|protein binding			cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(4)|urinary_tract(1)	16						CCTGTGAACTTGTGTCTCCAA	0.388000													19	51					0	0	1	0	0
XKR7	343702	broad.mit.edu	37	20	30556184	30556184	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr20:30556184C>T	ENST00000562532.2	+	1	380	c.206C>T	c.(205-207)tCc>tTc	p.S69F		NM_001011718.1	NP_001011718.1	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related family, member 7							integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(19)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	34			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			GTGTTCTTCTCCGACGGTGCC	0.706000													4	93					0	0	1	0	0
OR2W5	441932	broad.mit.edu	37	1	247654469	247654469	+	RNA	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr1:247654469C>T	ENST00000522351.1	+	0	100							A6NFC9	OR2W5_HUMAN							sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(24)|ovary(1)|skin(4)	39	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			GGCATTCATCCTGGTGGGCTC	0.473000													23	47					0	0	1	0	0
RP11-478B9.1	0	broad.mit.edu	37	12	45458068	45458068	+	RNA	SNP	A	A	C			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr12:45458068A>C	ENST00000548424.1	+	0	448																											ATCATTGGAAAAGTCTGGGAC	0.507000													32	37					0	0	1	0	0
RPL23AP53	644128	broad.mit.edu	37	8	163215	163215	+	RNA	SNP	G	G	A			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr8:163215G>A	ENST00000606975.1	-	0	706																											AGATACACATGTATTTAGAGT	0.323000													4	33					0	0	1	0	0
TCEB3B	51224	broad.mit.edu	37	18	44559943	44559943	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr18:44559943C>T	ENST00000332567.4	-	1	2045	c.1693G>A	c.(1693-1695)Gat>Aat	p.D565N	KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000592005.1_Intron|KATNAL2_ENST00000356157.7_Intron	NM_016427.2	NP_057511.2	Q8IYF1	ELOA2_HUMAN	transcription elongation factor B polypeptide 3B (elongin A2)	565	Activation domain (By similarity).				regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			breast(1)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|lung(24)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						TACAGCTGATCGGGCCTCCAC	0.527000													16	33					0	0	1	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54925052	54925052	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr12:54925052G>T	ENST00000293373.6	+	23	2594	c.2515G>T	c.(2515-2517)Gcc>Tcc	p.A839S	NCKAP1L_ENST00000545638.2_Missense_Mutation_p.A789S	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	839					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						AGAGATGCGGGCCTTGGCAGA	0.473000													50	179					1.67886e-27	1.81876e-27	1	1	0
SALL3	27164	broad.mit.edu	37	18	76754241	76754241	+	Silent	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr18:76754241C>T	ENST00000536229.3	+	1	2560	c.1851C>T	c.(1849-1851)aaC>aaT	p.N617N	SALL3_ENST00000575389.2_Silent_p.N750N|SALL3_ENST00000537592.2_Silent_p.N750N			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	750					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		AGTTCACCAACGCCGTGGTCC	0.657000													16	25					0	0	1	0	0
SLC9A7P1	121456	broad.mit.edu	37	12	98850235	98850235	+	RNA	SNP	G	G	A			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr12:98850235G>A	ENST00000554295.1	-	0	688					NR_033801.1																						TTTCCAATACGGAAGCACGAA	0.403000													13	46					0	0	1	0	0
SF3A3	10946	broad.mit.edu	37	1	38446335	38446335	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr1:38446335C>A	ENST00000373019.4	-	8	1568	c.613G>T	c.(613-615)Gat>Tat	p.D205Y	SF3A3_ENST00000489537.1_5'UTR|SF3A3_ENST00000448721.2_Missense_Mutation_p.D152Y	NM_006802.2	NP_006793.1	Q12874	SF3A3_HUMAN	splicing factor 3a, subunit 3, 60kDa	205					nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nuclear speck	nucleic acid binding|protein binding|zinc ion binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(3)|prostate(2)	12	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				TCATTCTGATCTTGGAGAGGC	0.453000													30	56					1.39806e-14	1.4809e-14	1	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33684079	33684079	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr5:33684079C>T	ENST00000504830.1	-	4	1051	c.716G>A	c.(715-717)cGg>cAg	p.R239Q	ADAMTS12_ENST00000504582.1_5'UTR|ADAMTS12_ENST00000352040.3_Missense_Mutation_p.R239Q	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	239					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						GATGGAACGCCGAGAGAGGCT	0.507000										HNSCC(64;0.19)			38	74					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240371020	240371020	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr1:240371020C>A	ENST00000319653.9	+	5	3138	c.2908C>A	c.(2908-2910)Ctt>Att	p.L970I		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	970	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TCCTCCCCCTCTTCCCGGAGC	0.701000													6	22					0.00198382	0.00201196	1	1	0
DENND1C	79958	broad.mit.edu	37	19	6477281	6477281	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr19:6477281G>A	ENST00000381480.2	-	8	573	c.461C>T	c.(460-462)aCg>aTg	p.T154M	DENND1C_ENST00000543576.1_Missense_Mutation_p.T110M|DENND1C_ENST00000591030.1_5'UTR	NM_024898.2	NP_079174.2	Q8IV53	DEN1C_HUMAN	DENN/MADD domain containing 1C	154	DENN.					clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			endometrium(3)|kidney(3)|large_intestine(1)|lung(3)	10						GCTGGAGACCGTCACTCCGCT	0.687000													6	20					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183245189	183245189	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr4:183245189C>T	ENST00000511685.1	+	2	139	c.16C>T	c.(16-18)Cgc>Tgc	p.R6C	TENM3_ENST00000406950.2_Missense_Mutation_p.R6C					teneurin transmembrane protein 3																		TGTGAAAGAACGCAGGCCTTA	0.517000													5	19					0	0	1	0	0
WWC2	80014	broad.mit.edu	37	4	184210770	184210770	+	Silent	SNP	G	G	A			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr4:184210770G>A	ENST00000403733.3	+	21	3565	c.3366G>A	c.(3364-3366)ctG>ctA	p.L1122L	WWC2_ENST00000448232.2_Silent_p.L1146L|WWC2_ENST00000508747.1_Silent_p.L250L|WWC2_ENST00000504005.1_Silent_p.L804L|WWC2_ENST00000513834.1_Silent_p.L1073L	NM_024949.5	NP_079225.5	Q6AWC2	WWC2_HUMAN	WW and C2 domain containing 2	1122								p.L1122L(1)		NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(15)|ovary(2)|prostate(1)|stomach(1)|urinary_tract(3)	32		all_lung(41;5.28e-14)|Lung NSC(41;1.35e-13)|Colorectal(36;0.00681)|Hepatocellular(41;0.00886)|Renal(120;0.00992)|Prostate(90;0.0237)|all_hematologic(60;0.0592)|Esophageal squamous(56;0.179)|all_neural(102;0.202)		all cancers(43;3.38e-24)|Epithelial(43;1.4e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.09e-09)|GBM - Glioblastoma multiforme(59;3.33e-05)|Colorectal(24;3.58e-05)|STAD - Stomach adenocarcinoma(60;4.21e-05)|COAD - Colon adenocarcinoma(29;0.000171)|LUSC - Lung squamous cell carcinoma(40;0.0145)|READ - Rectum adenocarcinoma(43;0.242)		AGAGGCTTCTGAAGCAAGCTG	0.542000													21	43					0	0	1	0	0
COL16A1	1307	broad.mit.edu	37	1	32120918	32120918	+	Silent	SNP	G	G	A			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr1:32120918G>A	ENST00000373672.3	-	67	4803	c.4287C>T	c.(4285-4287)tcC>tcT	p.S1429S	RP11-73M7.6_ENST00000591592.1_RNA|RP11-73M7.6_ENST00000609373.1_RNA|RP11-73M7.6_ENST00000609625.1_RNA|RP11-73M7.6_ENST00000585413.1_RNA|RP11-73M7.6_ENST00000593188.1_RNA|RP11-73M7.6_ENST00000610043.1_RNA|RP11-73M7.6_ENST00000591929.1_RNA|RP11-73M7.6_ENST00000608888.1_RNA|RP11-73M7.6_ENST00000609033.1_RNA|RP11-73M7.6_ENST00000607926.1_RNA|RP11-73M7.6_ENST00000585660.1_RNA|RP11-73M7.6_ENST00000609549.1_RNA|RP11-73M7.6_ENST00000587445.1_RNA|RP11-73M7.6_ENST00000610216.1_RNA|COL16A1_ENST00000271069.6_Silent_p.S1429S|RP11-73M7.6_ENST00000608246.1_RNA|RP11-73M7.6_ENST00000589462.1_RNA|COL16A1_ENST00000461217.1_5'UTR|RP11-73M7.6_ENST00000608332.1_RNA|RP11-73M7.6_ENST00000609338.1_RNA	NM_001856.3	NP_001847.3	Q07092	COGA1_HUMAN	collagen, type XVI, alpha 1	1429	Triple-helical region 2 (COL2) with 2 imperfections.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(15)|ovary(8)|prostate(4)	48		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		CCCTTACCATGGAGCCAGGCA	0.657000													6	32					0	0	1	0	0
ZNF175	7728	broad.mit.edu	37	19	52090224	52090224	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr19:52090224C>G	ENST00000262259.2	+	5	998	c.640C>G	c.(640-642)Cag>Gag	p.Q214E	ZNF175_ENST00000436511.2_Intron	NM_007147.2	NP_009078.1	Q9Y473	ZN175_HUMAN	zinc finger protein 175	214					response to virus	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	24		all_neural(266;0.0299)		GBM - Glioblastoma multiforme(134;0.000426)|OV - Ovarian serous cystadenocarcinoma(262;0.0257)		AGTGAACGGTCAGAATGAAAG	0.438000													20	51					0	0	1	0	0
XKR7	343702	broad.mit.edu	37	20	30556179	30556179	+	Missense_Mutation	SNP	C	C	G	rs11904972		TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr20:30556179C>G	ENST00000562532.2	+	1	375	c.201C>G	c.(199-201)ttC>ttG	p.F67L		NM_001011718.1	NP_001011718.1	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related family, member 7							integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(19)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	34			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			TGCTCGTGTTCTTCTCCGACG	0.711000													4	90					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113651024	113651024	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr8:113651024G>A	ENST00000297405.5	-	21	3671	c.3427C>T	c.(3427-3429)Cca>Tca	p.P1143S	CSMD3_ENST00000455883.2_Missense_Mutation_p.P1039S|CSMD3_ENST00000352409.3_Missense_Mutation_p.P1143S|CSMD3_ENST00000343508.3_Missense_Mutation_p.P1103S	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1143	CUB 6.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TTGATTGTTGGAGGAAGATCT	0.403000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			16	77					0	0	1	0	0
EXO1	9156	broad.mit.edu	37	1	242042339	242042339	+	Silent	SNP	T	T	A			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr1:242042339T>A	ENST00000366548.3	+	13	2396	c.1803T>A	c.(1801-1803)acT>acA	p.T601T	EXO1_ENST00000518483.1_Silent_p.T601T|EXO1_ENST00000348581.5_Silent_p.T601T	NM_130398.3	NP_569082.2	Q9UQ84	EXO1_HUMAN	exonuclease 1	601	Interaction with MSH2.				meiosis|mismatch repair	nucleus	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|flap endonuclease activity|metal ion binding|protein binding|ribonuclease H activity|single-stranded DNA specific 5'-3' exodeoxyribonuclease activity			NS(1)|central_nervous_system(2)|endometrium(3)|large_intestine(3)|lung(29)|ovary(2)|skin(1)|stomach(2)|urinary_tract(2)	45	Ovarian(103;0.103)	all_cancers(173;0.0555)	OV - Ovarian serous cystadenocarcinoma(106;0.0107)			CACCACCCACTTTGGGAACAC	0.453000								Editing and processing nucleases					44	86					0	0	1	0	0
RTL1	388015	broad.mit.edu	37	14	101350980	101350980	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr14:101350980C>T	ENST00000534062.1	-	1	204	c.146G>A	c.(145-147)aGc>aAc	p.S49N		NM_001134888.2	NP_001128360.1	E9PKS8	E9PKS8_HUMAN	retrotransposon-like 1	49										breast(1)|endometrium(5)|kidney(4)|large_intestine(1)|lung(5)|pancreas(1)|prostate(2)|skin(2)	21						GGCTGGGCCGCTGGCTGGCCC	0.602000													27	85					0	0	1	0	0
GJA5	2702	broad.mit.edu	37	1	147231196	147231196	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr1:147231196C>T	ENST00000271348.2	-	2	312	c.151G>A	c.(151-153)Gat>Aat	p.D51N	GJA5_ENST00000369237.1_Missense_Mutation_p.D51N	NM_005266.5	NP_005257.2	P36382	CXA5_HUMAN	gap junction protein, alpha 5, 40kDa	51					angiogenesis|cell-cell junction assembly|muscle contraction	integral to membrane				breast(3)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	20	all_hematologic(923;0.0276)		LUSC - Lung squamous cell carcinoma(543;0.202)			CACCGGAAATCAGCCTGCTCA	0.562000													19	33					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92087472	92087472	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr11:92087472G>C	ENST00000298047.6	+	1	2211	c.2194G>C	c.(2194-2196)Gat>Cat	p.D732H	FAT3_ENST00000525166.1_Missense_Mutation_p.D582H|FAT3_ENST00000541502.1_Missense_Mutation_p.D732H|FAT3_ENST00000409404.2_Missense_Mutation_p.D732H			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	732	Cadherin 7.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TTTTCCTTCTGATGTGGCTGT	0.383000										TCGA Ovarian(4;0.039)			42	127					0	0	1	0	0
CTIF	9811	broad.mit.edu	37	18	46287781	46287781	+	Silent	SNP	G	G	A	rs141427281	by1000genomes	TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr18:46287781G>A	ENST00000256413.3	+	9	1387	c.1092G>A	c.(1090-1092)acG>acA	p.T364T	CTIF_ENST00000382998.4_Silent_p.T366T	NM_014772.2	NP_055587.1	O43310	CTIF_HUMAN	CBP80/20-dependent translation initiation factor	364					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational initiation	perinuclear region of cytoplasm	protein binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(14)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	31						CCGTGGAGACGACCACTCCCC	0.577000													18	41					0	0	1	0	0
UBXN8	7993	broad.mit.edu	37	8	30612199	30612199	+	RNA	SNP	G	G	A			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr8:30612199G>A	ENST00000519246.1	+	0	499							O00124	UBXN8_HUMAN	UBX domain protein 8						single fertilization					central_nervous_system(1)|lung(2)	3						GATACATAGAGAATGTTTTAA	0.358000													6	74					0	0	1	0	0
CYP2D6	1565	broad.mit.edu	37	22	42523491	42523491	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr22:42523491C>T	ENST00000360608.5	-	7	1245	c.1131G>A	c.(1129-1131)atG>atA	p.M377I	NDUFA6-AS1_ENST00000416037.2_RNA|CYP2D6_ENST00000359033.4_Missense_Mutation_p.M326I|NDUFA6-AS1_ENST00000439129.1_RNA|CYP2D6_ENST00000389970.3_Missense_Mutation_p.M377I	NM_000106.5	NP_000097	Q6NWU0	Q6NWU0_HUMAN	cytochrome P450, family 2, subfamily D, polypeptide 6	377							electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen			NS(1)|breast(2)|endometrium(1)|large_intestine(2)|lung(4)|prostate(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						CACGGGATGTCATATGGGTCA	0.617000													9	28					0	0	1	0	0
NAA15	80155	broad.mit.edu	37	4	140258081	140258081	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr4:140258081G>C	ENST00000296543.5	+	3	542	c.219G>C	c.(217-219)ttG>ttC	p.L73F	NAA15_ENST00000480277.2_3'UTR|NAA15_ENST00000398947.1_Missense_Mutation_p.L73F	NM_057175.3	NP_476516.1	Q9BXJ9	NAA15_HUMAN	N(alpha)-acetyltransferase 15, NatA auxiliary subunit	73					angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			NS(1)|endometrium(3)|large_intestine(7)|liver(2)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	29						GTAGAGGTTTGAGAAATGACT	0.353000													6	40					0	0	1	0	0
TICAM1	148022	broad.mit.edu	37	19	4817687	4817687	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr19:4817687G>A	ENST00000248244.5	-	2	932	c.703C>T	c.(703-705)Cag>Tag	p.Q235*		NM_182919.3	NP_891549.1	Q8IUC6	TCAM1_HUMAN	toll-like receptor adaptor molecule 1	235	Pro-rich.				apoptosis|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein kinase binding|signal transducer activity			NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	26				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		AAGCTGGCCTGGGGGTCGTCA	0.672000													13	26					0	0	1	0	0
SF3A3	10946	broad.mit.edu	37	1	38446330	38446330	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr1:38446330C>A	ENST00000373019.4	-	8	1573	c.618G>T	c.(616-618)caG>caT	p.Q206H	SF3A3_ENST00000489537.1_5'UTR|SF3A3_ENST00000448721.2_Missense_Mutation_p.Q153H	NM_006802.2	NP_006793.1	Q12874	SF3A3_HUMAN	splicing factor 3a, subunit 3, 60kDa	206					nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nuclear speck	nucleic acid binding|protein binding|zinc ion binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(3)|prostate(2)	12	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				AAAGTTCATTCTGATCTTGGA	0.458000													30	56					1.39806e-14	1.4809e-14	1	1	0
KCNA3	3738	broad.mit.edu	37	1	111216307	111216307	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr1:111216307G>T	ENST00000369769.2	-	1	1348	c.1125C>A	c.(1123-1125)ttC>ttA	p.F375L		NM_002232.3	NP_002223.3	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 3	375						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(7)|ovary(4)|pancreas(1)|prostate(3)|skin(1)	38		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCGACAGCTTGAAGATGCGGA	0.602000													42	71					1.48734e-19	1.59917e-19	1	1	0
SPARCL1	8404	broad.mit.edu	37	4	88412020	88412020	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr4:88412020C>G	ENST00000418378.1	-	7	1873	c.1302G>C	c.(1300-1302)atG>atC	p.M434I	SPARCL1_ENST00000282470.6_Missense_Mutation_p.M434I|SPARCL1_ENST00000503414.1_Missense_Mutation_p.M309I	NM_001128310.1	NP_001121782.1	Q14515	SPRL1_HUMAN	SPARC-like 1 (hevin)	434	Follistatin-like.				signal transduction	extracellular space|proteinaceous extracellular matrix	calcium ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|skin(2)|stomach(2)	21				OV - Ovarian serous cystadenocarcinoma(123;0.00118)		ACTGGAAGCTCATGCAAGAAT	0.418000													13	44					0	0	1	0	0
OR4D2	124538	broad.mit.edu	37	17	56247358	56247358	+	Silent	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr17:56247358C>T	ENST00000545221.1	+	1	342	c.342C>T	c.(340-342)ttC>ttT	p.F114F		NM_001004707.3	NP_001004707.1	P58180	OR4D2_HUMAN	olfactory receptor, family 4, subfamily D, member 2	114					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(1)|lung(19)|ovary(1)|skin(2)|stomach(1)	26						TGGTCTTCTTCCTCTCAGTGA	0.552000													30	88					0	0	1	0	0
ZIC3	7547	broad.mit.edu	37	X	136649615	136649615	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chrX:136649615G>C	ENST00000287538.5	+	1	1315	c.765G>C	c.(763-765)tgG>tgC	p.W255C	ZIC3_ENST00000370606.3_Missense_Mutation_p.W255C	NM_003413.3	NP_003404.1	O60481	ZIC3_HUMAN	Zic family member 3	255			W -> G (in HTX1; decreases protein expression and transcriptional activity and increases its cytoplasmic localization).		cell differentiation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|large_intestine(3)|liver(1)|lung(18)|ovary(3)|soft_tissue(2)|urinary_tract(1)	37	Acute lymphoblastic leukemia(192;0.000127)					CGTGCAAGTGGATCGACGAGG	0.607000													31	18					0	0	1	0	0
ITGAD	3681	broad.mit.edu	37	16	31404690	31404690	+	Silent	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr16:31404690C>T	ENST00000389202.2	+	1	58	c.9C>T	c.(7-9)ttC>ttT	p.F3F		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	3					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						GGATGACCTTCGGCACTGTGC	0.587000													33	86					0	0	1	0	0
NRG1	3084	broad.mit.edu	37	8	32505705	32505705	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr8:32505705G>C	ENST00000520502.2	+	1	469	c.469G>C	c.(469-471)Gtg>Ctg	p.V157L	NRG1_ENST00000519301.1_Intron|NRG1_ENST00000356819.4_Intron|NRG1_ENST00000338921.4_Intron|NRG1_ENST00000520407.1_Intron|NRG1_ENST00000287845.5_Intron|NRG1_ENST00000523079.1_Intron|NRG1_ENST00000405005.3_Intron|NRG1_ENST00000287842.3_Intron|NRG1_ENST00000341377.5_Intron|NRG1_ENST00000521670.1_Intron	NM_013959.3	NP_039253.1	Q02297	NRG1_HUMAN	neuregulin 1	0					activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(1)|skin(1)	39		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		TCAAGTTACAGTGCAAGGTGA	0.512000													23	71					0	0	1	0	0
ZNF676	163223	broad.mit.edu	37	19	22363386	22363386	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr19:22363386G>A	ENST00000397121.2	-	3	1450	c.1133C>T	c.(1132-1134)tCa>tTa	p.S378L		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	378					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.S378L(1)		NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				ATTAAGGGTTGAGACCTTACT	0.393000													8	128					0	0	1	0	0
TDGF1P3	6998	broad.mit.edu	37	X	109764771	109764771	+	RNA	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chrX:109764771C>T	ENST00000602699.1	+	0	1232					NR_002718.2																						ACGGTCAGCTCCGCTGCTTTC	0.567000													22	15					0	0	1	0	0
VPS16	64601	broad.mit.edu	37	20	2843564	2843564	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr20:2843564C>T	ENST00000380445.3	+	13	1387	c.1315C>T	c.(1315-1317)Ccg>Tcg	p.P439S	VPS16_ENST00000380469.3_Intron|VPS16_ENST00000380443.3_Missense_Mutation_p.P125S|VPS16_ENST00000481812.2_3'UTR	NM_022575.2	NP_072097.2	Q9H269	VPS16_HUMAN	vacuolar protein sorting 16 homolog (S. cerevisiae)	439					intracellular protein transport	early endosome|HOPS complex|late endosome membrane|lysosomal membrane|recycling endosome				NS(3)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	37						CATCGGGATCCCGCTCACCTA	0.587000													36	115					0	0	1	0	0
SLIT1	6585	broad.mit.edu	37	10	98778794	98778794	+	Silent	SNP	G	G	C			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr10:98778794G>C	ENST00000266058.4	-	27	3062	c.2817C>G	c.(2815-2817)acC>acG	p.T939T	ARHGAP19-SLIT1_ENST00000453547.2_3'UTR|SLIT1_ENST00000371070.4_Silent_p.T939T	NM_003061.2	NP_003052.2	O75093	SLIT1_HUMAN	slit homolog 1 (Drosophila)	939	EGF-like 1.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(37)|ovary(5)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	78		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		CGTTGTGGCAGGTGCCCTGGT	0.637000													13	20					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51695725	51695725	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr6:51695725C>T	ENST00000371117.3	-	52	8511	c.8236G>A	c.(8236-8238)Gaa>Aaa	p.E2746K	PKHD1_ENST00000340994.4_Missense_Mutation_p.E2746K	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	2746					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					CAGCCTTCTTCAACACCTTGC	0.418000													26	27					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155298473	155298473	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr4:155298473C>A	ENST00000357232.4	-	3	357	c.358G>T	c.(358-360)Gtt>Ttt	p.V120F	DCHS2_ENST00000339452.1_Missense_Mutation_p.V726F	NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2		Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TCTTGAGAAACACAGATTTGC	0.418000													16	56					3.45872e-05	3.55825e-05	1	1	0
WNT9B	7484	broad.mit.edu	37	17	44953915	44953915	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr17:44953915G>T	ENST00000290015.2	+	4	958	c.905G>T	c.(904-906)gGt>gTt	p.G302V	WNT9B_ENST00000393461.2_Splice_Site	NM_003396.1	NP_003387.1	O14905	WNT9B_HUMAN	wingless-type MMTV integration site family, member 9B	302					anterior/posterior pattern formation|axis specification|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|collecting duct development|cornea development in camera-type eye|endoderm development|establishment of planar polarity involved in nephron morphogenesis|kidney rudiment formation|male genitalia development|mesonephric duct formation|metanephric tubule development|neuron differentiation|palate development|regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|uterus morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway|Wnt receptor signaling pathway, planar cell polarity pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding			large_intestine(2)|lung(8)	10			BRCA - Breast invasive adenocarcinoma(9;0.0257)			GGCACAGCAGGTAGGGTGTGC	0.667000													27	61					4.22769e-11	4.41285e-11	1	1	0
CCDC113	29070	broad.mit.edu	37	16	58287958	58287958	+	Silent	SNP	G	G	C			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr16:58287958G>C	ENST00000219299.4	+	3	364	c.285G>C	c.(283-285)ctG>ctC	p.L95L	CCDC113_ENST00000443128.2_Intron	NM_014157.3	NP_054876.2	Q9H0I3	CC113_HUMAN	coiled-coil domain containing 113	95						protein complex				large_intestine(4)|lung(6)|ovary(1)|urinary_tract(1)	12						GGGTAGGCCTGACTGCCGACC	0.517000													23	83					0	0	1	0	0
ZMYM2	7750	broad.mit.edu	37	13	20608481	20608481	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr13:20608481G>A	ENST00000382869.3	+	11	2307	c.2056G>A	c.(2056-2058)Gag>Aag	p.E686K	ZMYM2_ENST00000382874.2_Missense_Mutation_p.E686K|ZMYM2_ENST00000382871.2_Missense_Mutation_p.E686K|ZMYM2_ENST00000382883.3_Missense_Mutation_p.E168K	NM_001190965.1|NM_003453.3|NM_197968.2	NP_001177894.1|NP_003444.1|NP_932072.1	Q9UBW7	ZMYM2_HUMAN	zinc finger, MYM-type 2	686					regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	ubiquitin conjugating enzyme binding|zinc ion binding			large_intestine(3)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	10		all_cancers(29;8.65e-21)|all_epithelial(30;1.04e-18)|all_lung(29;6.75e-18)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;0.000148)|Epithelial(112;0.000249)|OV - Ovarian serous cystadenocarcinoma(117;0.00816)|Lung(94;0.0173)|LUSC - Lung squamous cell carcinoma(192;0.0856)		ATACTGTCAAGAGGAGAAGAC	0.358000													26	48					0	0	1	0	0
QRICH2	84074	broad.mit.edu	37	17	74278099	74278099	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr17:74278099G>T	ENST00000262765.5	-	8	3790	c.3611C>A	c.(3610-3612)cCt>cAt	p.P1204H		NM_032134.1	NP_115510.1	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	1204							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(2)|stomach(4)	62						GATCTGGCCAGGAGCCAAGGT	0.607000													8	9					0.00448238	0.00451395	1	1	0
KAT2B	8850	broad.mit.edu	37	3	20167474	20167474	+	Silent	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr3:20167474C>T	ENST00000263754.4	+	10	1946	c.1491C>T	c.(1489-1491)caC>caT	p.H497H		NM_003884.4	NP_003875.3	Q92831	KAT2B_HUMAN	K(lysine) acetyltransferase 2B	497					cell cycle arrest|cellular response to insulin stimulus|chromatin remodeling|histone H3 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|negative regulation of cell proliferation|transcription initiation from RNA polymerase I promoter	Ada2/Gcn5/Ada3 transcription activator complex|chromatin remodeling complex|PCAF complex	cyclin-dependent protein kinase inhibitor activity|histone acetyltransferase activity|histone deacetylase binding|protein kinase binding|transcription coactivator activity|transcription factor binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	40						TTGAATTTCACGTGGTTGGCA	0.512000													15	33					0	0	1	0	0
MAPRE2	10982	broad.mit.edu	37	18	32712102	32712102	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr18:32712102A>T	ENST00000436190.2	+	7	1095	c.821A>T	c.(820-822)aAt>aTt	p.N274I	MAPRE2_ENST00000589699.1_Missense_Mutation_p.N243I|MAPRE2_ENST00000300249.5_Missense_Mutation_p.N286I|MAPRE2_ENST00000413393.1_Missense_Mutation_p.N243I|MAPRE2_ENST00000538170.2_Missense_Mutation_p.N233I	NM_001143827.2	NP_001137299.1	Q15555	MARE2_HUMAN	microtubule-associated protein, RP/EB family, member 2	286	APC-binding.|DCTN1-binding.|EB1 C-terminal.				cell division|cell proliferation|mitosis|signal transduction	cytoplasm|microtubule	microtubule binding			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(3)|ovary(1)	9						GGGCAGGAAAATGATGACCTC	0.453000													12	30					0	0	1	0	0
OPCML	4978	broad.mit.edu	37	11	132399010	132399010	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr11:132399010A>C	ENST00000331898.7	-	3	1049	c.471T>G	c.(469-471)tgT>tgG	p.C157W	OPCML_ENST00000541867.1_Missense_Mutation_p.C157W|OPCML_ENST00000529038.1_5'UTR|OPCML_ENST00000524381.1_Missense_Mutation_p.C150W|OPCML_ENST00000374778.4_Missense_Mutation_p.C116W	NM_002545.3	NP_002536.1	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion molecule-like	157	Ig-like C2-type 2.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			endometrium(5)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|skin(2)|urinary_tract(8)	47	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		CAATAGCAAGACACAGCAGGG	0.468000													11	30					0	0	1	0	0
OR4K5	79317	broad.mit.edu	37	14	20389178	20389178	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr14:20389178G>A	ENST00000315915.4	+	1	438	c.413G>A	c.(412-414)cGa>cAa	p.R138Q		NM_001005483.1	NP_001005483.1	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K, member 5	138					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|liver(1)|lung(27)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ATCATGAGCCGAAGGACATGC	0.463000													41	291					0	0	1	0	0
CUX2	23316	broad.mit.edu	37	12	111748354	111748354	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr12:111748354G>A	ENST00000261726.6	+	15	1922	c.1768G>A	c.(1768-1770)Gag>Aag	p.E590K		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	590						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						CTCGGTCAGCGAGATCCTAGC	0.592000													30	99					0	0	1	0	0
LRRN3	54674	broad.mit.edu	37	7	110764137	110764137	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr7:110764137G>A	ENST00000451085.1	+	4	2355	c.1309G>A	c.(1309-1311)Ggg>Agg	p.G437R	LRRN3_ENST00000308478.5_Missense_Mutation_p.G437R|IMMP2L_ENST00000405709.2_Intron|LRRN3_ENST00000422987.3_Missense_Mutation_p.G437R|IMMP2L_ENST00000452895.1_Intron|IMMP2L_ENST00000489381.1_Intron|IMMP2L_ENST00000437687.1_Intron|IMMP2L_ENST00000447215.1_Intron|IMMP2L_ENST00000331762.3_Intron|IMMP2L_ENST00000415362.1_Intron|IMMP2L_ENST00000450877.1_Intron	NM_001099660.1	NP_001093130.1	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3	437	Ig-like C2-type.					integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(15)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		TGTAGAAGCTGGGAGCTATGT	0.438000													45	88					0	0	1	0	0
KCNT2	343450	broad.mit.edu	37	1	196367710	196367710	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr1:196367710A>T	ENST00000367433.5	-	13	1378	c.1277T>A	c.(1276-1278)tTt>tAt	p.F426Y	KCNT2_ENST00000294725.9_Missense_Mutation_p.F426Y|KCNT2_ENST00000367431.4_Missense_Mutation_p.F426Y|KCNT2_ENST00000451324.2_Missense_Mutation_p.F37Y|KCNT2_ENST00000498426.1_5'UTR|KCNT2_ENST00000609185.1_Missense_Mutation_p.F426Y	NM_198503.2	NP_940905.2	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	426	RCK N-terminal.					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						TTTGATGTGAAATTTATTTTC	0.363000													10	31					0	0	1	0	0
OR4D2	124538	broad.mit.edu	37	17	56247292	56247292	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr17:56247292C>G	ENST00000545221.1	+	1	276	c.276C>G	c.(274-276)atC>atG	p.I92M		NM_001004707.3	NP_001004707.1	P58180	OR4D2_HUMAN	olfactory receptor, family 4, subfamily D, member 2	92					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(1)|lung(19)|ovary(1)|skin(2)|stomach(1)	26						AGAAAACCATCTCTTACCAGG	0.502000													37	81					0	0	1	0	0
AC005609.1	0	broad.mit.edu	37	5	140242842	140242842	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr5:140242842C>T	ENST00000502505.1	-	1	382	c.134G>A	c.(133-135)cGg>cAg	p.R45Q	PCDHA2_ENST00000526136.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA14_ENST00000562220.1_RNA|PCDHA10_ENST00000506939.2_Intron																							CGTCGAGGTCCGGGAGGCAGC	0.657000													25	25					0	0	1	0	0
GREB1	9687	broad.mit.edu	37	2	11758778	11758778	+	Silent	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr2:11758778C>T	ENST00000381486.2	+	22	4077	c.3777C>T	c.(3775-3777)gtC>gtT	p.V1259V	GREB1_ENST00000234142.5_Silent_p.V1259V|GREB1_ENST00000396123.1_Silent_p.V257V	NM_014668.3	NP_055483.2	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	1259						integral to membrane				breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		CACCCATTGTCTTCTTGCCCA	0.672000													8	25					0	0	1	0	0
SFMBT2	57713	broad.mit.edu	37	10	7214540	7214540	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr10:7214540T>A	ENST00000361972.4	-	18	2158	c.2068A>T	c.(2068-2070)Agg>Tgg	p.R690W	SFMBT2_ENST00000397167.1_Missense_Mutation_p.R690W	NM_001018039.1	NP_001018049.1	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	690					regulation of transcription, DNA-dependent	nucleus				NS(2)|breast(3)|central_nervous_system(4)|endometrium(7)|kidney(2)|large_intestine(26)|lung(34)|ovary(5)|pancreas(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	99						TTCCTCCGCCTGGCGGGTTTG	0.582000													10	30					0	0	1	0	0
CHD4	1108	broad.mit.edu	37	12	6691834	6691834	+	Silent	SNP	A	A	G			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr12:6691834A>G	ENST00000309577.6	-	28	4564	c.4401T>C	c.(4399-4401)ttT>ttC	p.F1467F	CHD4_ENST00000357008.2_Silent_p.F1439F|CHD4_ENST00000544040.1_Silent_p.F1432F|CHD4_ENST00000544484.1_Silent_p.F1464F|RP5-940J5.6_ENST00000501075.2_RNA|CHD4_ENST00000540960.1_5'UTR			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1439					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						ACTGGGTAGTAAAAGCATCCT	0.468000													64	171					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51695724	51695724	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr6:51695724T>A	ENST00000371117.3	-	52	8512	c.8237A>T	c.(8236-8238)gAa>gTa	p.E2746V	PKHD1_ENST00000340994.4_Missense_Mutation_p.E2746V	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	2746					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					CCAGCCTTCTTCAACACCTTG	0.418000													28	27					0	0	1	0	0
NPM3	10360	broad.mit.edu	37	10	103542338	103542338	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr10:103542338C>G	ENST00000370110.5	-	3	243	c.221G>C	c.(220-222)gGa>gCa	p.G74A	NPM3_ENST00000474993.1_5'UTR	NM_006993.2	NP_008924.1	O75607	NPM3_HUMAN	nucleophosmin/nucleoplasmin 3	74							nucleic acid binding			large_intestine(3)|lung(1)|skin(1)	5		Colorectal(252;0.122)		Epithelial(162;3.94e-09)|all cancers(201;2.13e-07)		GTCTTTGGCTCCCTCGGTGAG	0.577000													5	25					0	0	1	0	0
GRIN2D	2906	broad.mit.edu	37	19	48908042	48908042	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr19:48908042C>T	ENST00000263269.3	+	3	605	c.517C>T	c.(517-519)Cag>Tag	p.Q173*		NM_000836.2	NP_000827.2	O15399	NMDE4_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2D	173						cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|protein binding			autonomic_ganglia(1)|breast(6)|endometrium(2)|large_intestine(9)|lung(12)|ovary(5)|pancreas(1)|prostate(1)	37		all_epithelial(76;1.11e-06)|all_lung(116;5.79e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		all cancers(93;0.00014)|OV - Ovarian serous cystadenocarcinoma(262;0.000233)|Epithelial(262;0.0112)|GBM - Glioblastoma multiforme(486;0.0161)	L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Orphenadrine(DB01173)	GCAACAGCTTCAGGTCATCTT	0.602000													69	143					0	0	1	0	0
CALCRL	10203	broad.mit.edu	37	2	188225373	188225373	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr2:188225373C>T	ENST00000409998.1	-	11	1514	c.733G>A	c.(733-735)Gtg>Atg	p.V245M	CALCRL_ENST00000410068.1_Missense_Mutation_p.V245M|CALCRL_ENST00000392370.3_Missense_Mutation_p.V245M|AC007319.1_ENST00000453517.1_RNA|AC007319.1_ENST00000412276.1_RNA			Q16602	CALRL_HUMAN	calcitonin receptor-like	245						integral to plasma membrane				endometrium(1)|large_intestine(7)|lung(21)|ovary(1)|prostate(1)|skin(1)	32			OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(96;0.227)			TCTGCAAACACGGCCACCACA	0.398000													17	64					0	0	1	0	0
LRRK2	120892	broad.mit.edu	37	12	40651079	40651079	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr12:40651079G>A	ENST00000298910.7	+	12	1376	c.1318G>A	c.(1318-1320)Gga>Aga	p.G440R	LRRK2_ENST00000343742.2_Missense_Mutation_p.G440R	NM_198578.3	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	440					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				GTTATCAAAAGGAATACACCT	0.289000													13	95					0	0	1	0	0
DMRTA2	63950	broad.mit.edu	37	1	50884417	50884417	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr1:50884417C>T	ENST00000404795.3	-	3	1941	c.1549G>A	c.(1549-1551)Gct>Act	p.A517T	DMRTA2_ENST00000418121.1_Missense_Mutation_p.A517T	NM_032110.2	NP_115486.1	Q96SC8	DMTA2_HUMAN	DMRT-like family A2	517	Ala-rich.				sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|lung(4)|pancreas(1)	6						ACCGCCGCAGCAGCGGCGGCC	0.706000													4	7					0	0	1	0	0
RALYL	138046	broad.mit.edu	37	8	85799889	85799889	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr8:85799889T>G	ENST00000521268.1	+	8	1841	c.736T>G	c.(736-738)Tgt>Ggt	p.C246G	RALYL_ENST00000521695.1_Missense_Mutation_p.C246G|RALYL_ENST00000523850.1_Missense_Mutation_p.C173G|RALYL_ENST00000521376.1_Intron|RALYL_ENST00000518566.1_Missense_Mutation_p.C235G|RALYL_ENST00000522455.1_Missense_Mutation_p.C246G|RALYL_ENST00000517638.1_Missense_Mutation_p.C259G	NM_173848.5	NP_776247.3	Q86SE5	RALYL_HUMAN	RALY RNA binding protein-like	246							identical protein binding|nucleotide binding|RNA binding			endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)	24						CCAAGAGGAATGTGTGTCAGA	0.512000													22	93					0	0	1	0	0
OVCH1	341350	broad.mit.edu	37	12	29624842	29624842	+	Silent	SNP	G	G	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr12:29624842G>T	ENST00000318184.5	-	16	1748	c.1749C>A	c.(1747-1749)ccC>ccA	p.P583P	OVCH1-AS1_ENST00000549411.1_Intron|OVCH1-AS1_ENST00000551108.1_Intron	NM_183378.2	NP_899234.2	Q7RTY7	OVCH1_HUMAN	ovochymase 1	583	Peptidase S1 2.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(43)|ovary(5)|pancreas(3)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)	92	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					GCCAACAGTGGGGGCAGGCTT	0.542000													11	30					2.80697e-09	2.90868e-09	1	1	0
SOS1	6654	broad.mit.edu	37	2	39250176	39250176	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr2:39250176C>G	ENST00000426016.1	-	11	1479	c.1393G>C	c.(1393-1395)Gat>Cat	p.D465H	SOS1_ENST00000472480.1_5'UTR|SOS1_ENST00000395038.2_Missense_Mutation_p.D465H|SOS1_ENST00000402219.2_Missense_Mutation_p.D465H			Q07889	SOS1_HUMAN	son of sevenless homolog 1 (Drosophila)	465	PH.				apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(29)|ovary(4)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	75		all_hematologic(82;0.21)				ATTAAGCCATCAAAGAGAAAT	0.378000									Noonan syndrome				33	62					0	0	1	0	0
TEDDM1	127670	broad.mit.edu	37	1	182369290	182369290	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr1:182369290G>C	ENST00000367565.1	-	1	461	c.331C>G	c.(331-333)Ctc>Gtc	p.L111V		NM_172000.3	NP_741997.3	Q5T9Z0	TEDM1_HUMAN	transmembrane epididymal protein 1	111						integral to membrane				haematopoietic_and_lymphoid_tissue(1)|lung(4)|ovary(2)	7						AGCAGCAGGAGCTCGTAGATG	0.502000													8	138					0	0	1	0	0
CD19	930	broad.mit.edu	37	16	28943334	28943334	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr16:28943334C>T	ENST00000538922.1	+	1	75	c.13C>T	c.(13-15)Cgc>Tgc	p.R5C	CD19_ENST00000324662.3_Missense_Mutation_p.R5C|CD19_ENST00000567541.1_Missense_Mutation_p.R5C	NM_001178098.1|NM_001770.5	NP_001171569.1|NP_001761.3	P15391	CD19_HUMAN	CD19 molecule	5					cellular defense response	external side of plasma membrane|integral to plasma membrane	protein binding|receptor signaling protein activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|ovary(2)|skin(4)|urinary_tract(1)	29						GCCACCTCCTCGCCTCCTCTT	0.622000													18	62					0	0	1	0	0
TPK1	27010	broad.mit.edu	37	7	144288604	144288604	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr7:144288604G>C	ENST00000549981.1	-	9	785	c.62C>G	c.(61-63)tCt>tGt	p.S21C	TPK1_ENST00000378099.3_Intron|TPK1_ENST00000547966.1_5'UTR|TPK1_ENST00000538212.2_Intron|TPK1_ENST00000360057.3_Missense_Mutation_p.S138C			Q9H3S4	TPK1_HUMAN	thiamin pyrophosphokinase 1	138					thiamine diphosphate biosynthetic process	cytosol	ATP binding|kinase activity|thiamine diphosphokinase activity			large_intestine(3)|lung(12)|ovary(2)|urinary_tract(2)	19					Thiamine(DB00152)	GGTATTCACAGATGCCATAAT	0.453000													3	53					0	0	1	0	0
HSD3B2	3284	broad.mit.edu	37	1	119962125	119962125	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr1:119962125C>T	ENST00000543831.1	+	3	476	c.227C>T	c.(226-228)tCg>tTg	p.S76L	HSD3B2_ENST00000471656.1_3'UTR|HSD3B2_ENST00000369416.3_Missense_Mutation_p.S76L	NM_001166120.1	NP_001159592.1	P26439	3BHS2_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	76					androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity	p.S76L(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(19)|ovary(2)|skin(1)	27	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	CAGGACGTCTCGGTCGTCATC	0.502000													19	42					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37027150	37027150	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chrX:37027150C>T	ENST00000358047.3	+	1	719	c.667C>T	c.(667-669)Cgc>Tgc	p.R223C		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	223										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						GTCCCATCTCCGCCCACAGCC	0.657000													44	32					0	0	1	0	0
LRRC18	474354	broad.mit.edu	37	10	50121796	50121796	+	Silent	SNP	G	G	A	rs143092104	byFrequency	TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr10:50121796G>A	ENST00000374160.3	-	1	481	c.405C>T	c.(403-405)agC>agT	p.S135S	RP11-523O18.7_ENST00000430438.1_RNA|WDFY4_ENST00000413659.2_Intron|WDFY4_ENST00000325239.5_Intron|LRRC18_ENST00000298124.3_Silent_p.S135S	NM_001006939.3	NP_001006940.3	Q8N456	LRC18_HUMAN	leucine rich repeat containing 18	135						cytoplasm				NS(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	18						TGGTGGGCACGCTGTCCAGGT	0.602000													10	30					0	0	1	0	0
MAP9	79884	broad.mit.edu	37	4	156281423	156281423	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr4:156281423T>A	ENST00000311277.4	-	7	1210	c.947A>T	c.(946-948)aAg>aTg	p.K316M	AC097467.2_ENST00000609716.1_RNA|AC097467.2_ENST00000609254.1_RNA|AC097467.2_ENST00000598890.1_RNA|AC097467.2_ENST00000417474.1_RNA|AC097467.2_ENST00000600928.1_RNA|AC097467.2_ENST00000608406.1_RNA|AC097467.2_ENST00000594492.1_RNA|AC097467.2_ENST00000594666.1_RNA|AC097467.2_ENST00000597831.1_RNA|AC097467.2_ENST00000596165.1_RNA|MAP9_ENST00000515654.1_Missense_Mutation_p.K292M|AC097467.2_ENST00000596754.1_RNA|AC097467.2_ENST00000598252.1_RNA|AC097467.2_ENST00000608544.1_RNA|AC097467.2_ENST00000608762.1_RNA	NM_001039580.1	NP_001034669.1	Q49MG5	MAP9_HUMAN	microtubule-associated protein 9	316					cell division|mitosis	cytoplasm|microtubule|spindle				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	26	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.143)		CGCTTTTGCCTTTTCTTCTTC	0.383000													20	64					0	0	1	0	0
SLC28A1	9154	broad.mit.edu	37	15	85452005	85452005	+	Silent	SNP	C	C	G			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr15:85452005C>G	ENST00000394573.1	+	9	976	c.774C>G	c.(772-774)gtC>gtG	p.V258V	SLC28A1_ENST00000538177.1_Silent_p.V258V|SLC28A1_ENST00000286749.3_Silent_p.V258V|SLC28A1_ENST00000537703.1_Silent_p.V180V|SLC28A1_ENST00000537624.1_Silent_p.V258V|SLC28A1_ENST00000537216.1_Silent_p.V258V	NM_004213.3	NP_004204.3	O00337	S28A1_HUMAN	solute carrier family 28 (concentrative nucleoside transporter), member 1	258					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	41			BRCA - Breast invasive adenocarcinoma(143;0.0587)			AGGCGCTGGTCAAGGATGTCT	0.547000													6	42					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125094608	125094608	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr8:125094608G>A	ENST00000522917.1	+	33	4506	c.4300G>A	c.(4300-4302)Gat>Aat	p.D1434N	FER1L6-AS2_ENST00000520031.1_RNA|FER1L6_ENST00000399018.1_Missense_Mutation_p.D1434N	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	1434	C2 5.					integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GATTGGCACAGATGACCTTAT	0.493000													55	170					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117768176	117768176	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr12:117768176C>A	ENST00000317775.6	-	2	1384	c.699G>T	c.(697-699)atG>atT	p.M233I	NOS1_ENST00000338101.4_Missense_Mutation_p.M233I|NOS1_ENST00000344089.3_Missense_Mutation_p.M233I	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	233	PIN (nNOS-inhibiting protein) binding.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding	p.M233I(1)		NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	CCATATCTTTCATCTCTGCCT	0.547000													19	78					2.35188e-11	2.47293e-11	1	1	0
KIAA2026	158358	broad.mit.edu	37	9	5968523	5968523	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr9:5968523C>T	ENST00000399933.3	-	3	1707	c.1708G>A	c.(1708-1710)Gaa>Aaa	p.E570K	KIAA2026_ENST00000381461.2_Missense_Mutation_p.E570K	NM_001017969.2	NP_001017969.2	Q5HYC2	K2026_HUMAN	KIAA2026	570										breast(6)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(1)	46		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		ATTCTAATTTCATAGTTGGAT	0.363000													34	34					0	0	1	0	0
ARHGEF2	9181	broad.mit.edu	37	1	155920635	155920635	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr1:155920635A>T	ENST00000462460.2	-	24	3077	c.2823T>A	c.(2821-2823)agT>agA	p.S941R	ARHGEF2_ENST00000313695.7_Missense_Mutation_p.S868R|ARHGEF2_ENST00000368316.1_Missense_Mutation_p.S868R|ARHGEF2_ENST00000368315.4_Missense_Mutation_p.S897R|ARHGEF2_ENST00000313667.4_Missense_Mutation_p.S895R|ARHGEF2_ENST00000361247.4_Missense_Mutation_p.S896R|ARHGEF2_ENST00000477754.2_Intron			Q92974	ARHG2_HUMAN	Rho/Rac guanine nucleotide exchange factor (GEF) 2						actin filament organization|apoptosis|cell division|cell morphogenesis|induction of apoptosis by extracellular signals|intracellular protein transport|mitosis|negative regulation of microtubule depolymerization|nerve growth factor receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|regulation of cell proliferation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|Golgi apparatus|microtubule|ruffle membrane|spindle|tight junction	microtubule binding|Rac GTPase binding|Rac guanyl-nucleotide exchange factor activity|zinc ion binding			breast(4)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|skin(2)	40	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					GGGGGTTGAAACTCAAGTACA	0.637000													42	82					0	0	1	0	0
HIPK4	147746	broad.mit.edu	37	19	40895605	40895605	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr19:40895605C>G	ENST00000291823.2	-	1	489	c.205G>C	c.(205-207)Gag>Cag	p.E69Q		NM_144685.3	NP_653286.2	Q8NE63	HIPK4_HUMAN	homeodomain interacting protein kinase 4	69	Protein kinase.					cytoplasm	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(5)|large_intestine(2)|lung(5)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	20			Lung(22;4.95e-05)|LUSC - Lung squamous cell carcinoma(20;0.000292)			ACGTGGGCCTCTTCAGGGTCT	0.537000													8	163					0	0	1	0	0
GABRB3	2562	broad.mit.edu	37	15	26793250	26793250	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr15:26793250G>A	ENST00000541819.2	-	10	1382	c.1280C>T	c.(1279-1281)tCg>tTg	p.S427L	GABRB3_ENST00000311550.5_Missense_Mutation_p.S371L|GABRB3_ENST00000299267.4_Missense_Mutation_p.S371L|GABRB3_ENST00000545868.1_Missense_Mutation_p.S286L|GABRB3_ENST00000400188.3_Missense_Mutation_p.S300L			P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 3	371					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(41)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	68		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	AACTTCCAGCGATGTCAACAG	0.453000													4	117					0	0	1	0	0
ACAT1	38	broad.mit.edu	37	11	108005886	108005886	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr11:108005886C>G	ENST00000265838.4	+	5	443	c.352C>G	c.(352-354)Cca>Gca	p.P118A	ACAT1_ENST00000299355.6_Missense_Mutation_p.P118A	NM_000019.3	NP_000010.1	P24752	THIL_HUMAN	acetyl-CoA acetyltransferase 1	118					acetoacetic acid biosynthetic process|branched chain family amino acid catabolic process|ketone body biosynthetic process|ketone body catabolic process	mitochondrial matrix	acetyl-CoA C-acetyltransferase activity|metal ion binding			endometrium(1)|large_intestine(1)|lung(3)|ovary(3)|prostate(2)	10		all_cancers(61;6.41e-10)|all_epithelial(67;2.83e-06)|Melanoma(852;1.46e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;2.96e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.00108)|OV - Ovarian serous cystadenocarcinoma(223;0.192)	Sulfasalazine(DB00795)	TATTTCTACTCCATGTACCAC	0.378000													26	72					0	0	1	0	0
IPO13	9670	broad.mit.edu	37	1	44432419	44432419	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr1:44432419G>A	ENST00000372343.3	+	17	3150	c.2488G>A	c.(2488-2490)Gag>Aag	p.E830K	IPO13_ENST00000372339.3_Missense_Mutation_p.E48K	NM_014652.3	NP_055467.3	O94829	IPO13_HUMAN	importin 13	830					protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(6)|lung(13)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				CAAGTTCCCTGAGGCACCTAC	0.607000													10	56					0	0	1	0	0
GPATCH1	55094	broad.mit.edu	37	19	33588685	33588685	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr19:33588685G>C	ENST00000170564.2	+	8	1191	c.877G>C	c.(877-879)Gag>Cag	p.E293Q		NM_018025.2	NP_060495.2	Q9BRR8	GPTC1_HUMAN	G patch domain containing 1	293						catalytic step 2 spliceosome	nucleic acid binding			breast(4)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(15)|prostate(4)|skin(4)	40	Esophageal squamous(110;0.137)					TGCCCTGGAAGAGGAAGATGA	0.458000													41	94					0	0	1	0	0
GALR2	8811	broad.mit.edu	37	17	74071066	74071066	+	Silent	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr17:74071066C>T	ENST00000329003.3	+	1	192	c.102C>T	c.(100-102)ctC>ctT	p.L34L		NM_003857.2	NP_003848.1	O43603	GALR2_HUMAN	galanin receptor 2	34					digestion|elevation of cytosolic calcium ion concentration|feeding behavior|learning or memory|muscle contraction	integral to membrane|plasma membrane	galanin receptor activity			cervix(1)|lung(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	8						TCTTCGCGCTCATCTTCCTCG	0.706000													8	16					0	0	1	0	0
WNT9B	7484	broad.mit.edu	37	17	44952649	44952649	+	Silent	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr17:44952649C>T	ENST00000393461.2	+	3	570	c.517C>T	c.(517-519)Ctg>Ttg	p.L173L	WNT9B_ENST00000290015.2_Silent_p.L173L			O14905	WNT9B_HUMAN	wingless-type MMTV integration site family, member 9B	173					anterior/posterior pattern formation|axis specification|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|collecting duct development|cornea development in camera-type eye|endoderm development|establishment of planar polarity involved in nephron morphogenesis|kidney rudiment formation|male genitalia development|mesonephric duct formation|metanephric tubule development|neuron differentiation|palate development|regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|uterus morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway|Wnt receptor signaling pathway, planar cell polarity pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding			large_intestine(2)|lung(8)	10			BRCA - Breast invasive adenocarcinoma(9;0.0257)			CACCAAGTTTCTGAGCAACTT	0.622000													10	22					0	0	1	0	0
PTPRS	5802	broad.mit.edu	37	19	5212433	5212433	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr19:5212433C>T	ENST00000372412.4	-	31	4920	c.4687G>A	c.(4687-4689)Gaa>Aaa	p.E1563K	PTPRS_ENST00000587303.1_Missense_Mutation_p.E1562K|PTPRS_ENST00000262963.6_Missense_Mutation_p.E1542K|PTPRS_ENST00000588552.1_5'UTR|PTPRS_ENST00000353284.2_Missense_Mutation_p.E1115K|PTPRS_ENST00000348075.2_Missense_Mutation_p.E1524K|PTPRS_ENST00000588012.1_Missense_Mutation_p.E1524K|PTPRS_ENST00000357368.4_Missense_Mutation_p.E1562K|PTPRS_ENST00000592099.1_Missense_Mutation_p.E1115K			Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type, S	1562	Tyrosine-protein phosphatase 1.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(9)|ovary(4)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)	61				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		GTTGGGTATTCGGGCACGCCA	0.622000													7	10					0	0	1	0	0
XKR7	343702	broad.mit.edu	37	20	30556185	30556185	+	Silent	SNP	C	C	T			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr20:30556185C>T	ENST00000562532.2	+	1	381	c.207C>T	c.(205-207)tcC>tcT	p.S69S		NM_001011718.1	NP_001011718.1	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related family, member 7							integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(19)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	34			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			TGTTCTTCTCCGACGGTGCCA	0.706000													4	94					0	0	1	0	0
CYP4B1	1580	broad.mit.edu	37	1	47276490	47276491	+	Frame_Shift_Ins	INS	-	-	G			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr1:47276490_47276491insG	ENST00000271153.4	+	2	227_228	c.191_192insG	c.(190-195)acggggfs	p.TG64fs	CYP4B1_ENST00000546128.1_3'UTR|CYP4B1_ENST00000371923.4_Frame_Shift_Ins_p.TG64fs|CYP4B1_ENST00000371919.4_Frame_Shift_Ins_p.TG64fs			P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B, polypeptide 1	64					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	36	Acute lymphoblastic leukemia(166;0.155)					ATCCAGGAGACGGGGAGCCTGG	0.579													20	62	---	---	---	---					
SRGAP2-AS1	100873165	broad.mit.edu	37	1	121137698	121137699	+	RNA	INS	-	-	TT	rs57730437		TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr1:121137698_121137699insTT	ENST00000437515.1	-	0	329					NR_104189.1																						CTACTTACATCTTTTTGTCTTT	0.441													9	41	---	---	---	---					
THSD7B	80731	broad.mit.edu	37	2	137928475	137928475	+	Frame_Shift_Del	DEL	C	C	-			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr2:137928475delC	ENST00000409968.1	+	7	1868	c.1690delC	c.(1690-1692)cgtfs	p.R564fs	THSD7B_ENST00000543459.1_Intron|THSD7B_ENST00000485379.1_3'UTR|THSD7B_ENST00000272643.3_Frame_Shift_Del_p.R564fs|THSD7B_ENST00000413152.2_Frame_Shift_Del_p.R533fs					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		CCTGGGACATCGTATTCTGAA	0.502													19	35	---	---	---	---					
NIPAL1	152519	broad.mit.edu	37	4	48037608	48037619	+	In_Frame_Del	DEL	GTGATCTCCTTG	GTGATCTCCTTG	-			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr4:48037608_48037619delGTGATCTCCTTG	ENST00000295461.5	+	6	718_729	c.652_663delGTGATCTCCTTG	c.(652-663)gtgatctccttgdel	p.VISL218del	NIPAL1_ENST00000508180.1_3'UTR	NM_207330.1	NP_997213.1	Q6NVV3	NIPA3_HUMAN	NIPA-like domain containing 1	218						integral to membrane		p.S220S(1)		endometrium(2)|large_intestine(1)|lung(3)|skin(2)	8						GATCATAACTGTGATCTCCTTGGTGCTGATTT	0.363													23	125	---	---	---	---					
CDKN1A	1026	broad.mit.edu	37	6	36652067	36652067	+	Frame_Shift_Del	DEL	C	C	-	rs4986867	byFrequency	TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr6:36652067delC	ENST00000405375.1	+	2	424	c.189delC	c.(187-189)ttcfs	p.F63fs	CDKN1A_ENST00000373711.2_Frame_Shift_Del_p.F63fs|CDKN1A_ENST00000478800.1_3'UTR|CDKN1A_ENST00000448526.2_Frame_Shift_Del_p.F97fs|CDKN1A_ENST00000244741.5_Frame_Shift_Del_p.F63fs	NM_001220778.1	NP_001207707.1	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	63			F -> L (in dbSNP:rs4986867).		cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|urinary_tract(5)	15						AGGGTGACTTCGCCTGGGAGC	0.672													17	38	---	---	---	---					
GPR19	2842	broad.mit.edu	37	12	12814274	12814274	+	Frame_Shift_Del	DEL	T	T	-			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr12:12814274delT	ENST00000540510.1	-	2	1301	c.1109delA	c.(1108-1110)aacfs	p.N370fs	GPR19_ENST00000332427.2_Frame_Shift_Del_p.N370fs			Q15760	GPR19_HUMAN	G protein-coupled receptor 19	370						integral to plasma membrane	G-protein coupled receptor activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	17		Prostate(47;0.0802)		BRCA - Breast invasive adenocarcinoma(232;0.048)		GCCAACGTAGTTTTTTTTGGC	0.398													7	245	---	---	---	---					
TMTC3	160418	broad.mit.edu	37	12	88584241	88584242	+	Frame_Shift_Ins	INS	-	-	A			TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr12:88584241_88584242insA	ENST00000266712.6	+	12	1768_1769	c.1548_1549insA	c.(1549-1551)aaafs	p.K517fs		NM_181783.3	NP_861448.2	Q6ZXV5	TMTC3_HUMAN	transmembrane and tetratricopeptide repeat containing 3	517						integral to membrane	binding			NS(1)|breast(2)|endometrium(1)|kidney(4)|large_intestine(5)|liver(1)|lung(12)|prostate(4)|skin(1)	31						TTATTCCTGGTAAAAAATATGC	0.347													22	82	---	---	---	---					
FRG1B	284802	broad.mit.edu	37	20	29628226	29628226	+	Splice_Site	DEL	G	G	-	rs78710112	by1000genomes	TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr20:29628226delG	ENST00000278882.3	+	6	608		c.e6-1		FRG1B_ENST00000358464.4_Splice_Site|FRG1B_ENST00000439954.2_Splice_Site																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GTTTCACTTAGGGGAAAATGG	0.358													12	138	---	---	---	---					
KRTAP10-7	386675	broad.mit.edu	37	21	46020656	46020670	+	In_Frame_Del	DEL	CTGCTGCGCCCCCAG	CTGCTGCGCCCCCAG	-	rs36208679		TCGA-ZF-A9R1-01A-11D-A391-08	TCGA-ZF-A9R1-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbaa26d9-b88b-4fa3-8bbc-28ebab5f90b6	a06ba712-79fb-4338-a707-cc1f490cc7c3	g.chr21:46020656_46020670delCTGCTGCGCCCCCAG	ENST00000380102.2	+	1	160_174	c.135_149delCTGCTGCGCCCCCAG	c.(133-150)ccctgctgcgcccccagc>ccc	p.CCAPS46del	TSPEAR_ENST00000323084.4_Intron	NM_198689.2	NP_941962.1	P60409	KR107_HUMAN	keratin associated protein 10-7	46	30 X 5 AA repeats of C-C-X(3).					keratin filament		p.S50_P54delSCCAP(1)		breast(1)|large_intestine(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	8						GCGAGCCCCCCTGCTGCGCCCCCAGCTGCTGCGCC	0.698													9	23	---	---	---	---