Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
C16orf70	80262	broad.mit.edu	37	16	67159865	67159865	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr16:67159865C>A	ENST00000219139.3	+	3	339	c.151C>A	c.(151-153)Cct>Act	p.P51T	C16orf70_ENST00000569683.1_3'UTR|C16orf70_ENST00000569600.1_Missense_Mutation_p.P51T	NM_025187.3	NP_079463.2	Q9BSU1	CP070_HUMAN	chromosome 16 open reading frame 70	51										cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(3)|skin(1)	17		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0017)|Epithelial(162;0.00655)|all cancers(182;0.0579)		TTTGTAGTCTCCTCTAAGCCA	0.348000													88	71					5.52034e-35	5.87621e-35	1	1	0
GPR12	2835	broad.mit.edu	37	13	27333462	27333462	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr13:27333462G>T	ENST00000405846.3	-	2	724	c.503C>A	c.(502-504)tCc>tAc	p.S168Y	GPR12_ENST00000381436.2_Missense_Mutation_p.S168Y	NM_005288.3	NP_005279.1	P47775	GPR12_HUMAN	G protein-coupled receptor 12	168						integral to plasma membrane				endometrium(7)|kidney(2)|large_intestine(6)|lung(14)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33	Colorectal(5;5.77e-05)	Breast(139;0.198)		Epithelial(112;9.37e-07)|OV - Ovarian serous cystadenocarcinoma(117;1.16e-06)|all cancers(112;8.31e-06)|GBM - Glioblastoma multiforme(144;0.00121)|Lung(94;0.111)|LUSC - Lung squamous cell carcinoma(192;0.184)		CAGGCAGATGGAGGTCCCCCA	0.597000													25	26					1.64293e-13	1.68781e-13	1	1	0
CASD1	64921	broad.mit.edu	37	7	94173797	94173797	+	Silent	SNP	A	A	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr7:94173797A>G	ENST00000297273.4	+	11	1718	c.1431A>G	c.(1429-1431)tcA>tcG	p.S477S		NM_022900.4	NP_075051.4	Q96PB1	CASD1_HUMAN	CAS1 domain containing 1	477						integral to membrane				NS(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(13)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	31	all_cancers(62;6.71e-10)|all_epithelial(64;5e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			GGCATTTCTCATACTTTTGGA	0.353000													49	102					0	0	1	0	0
ITIH4	3700	broad.mit.edu	37	3	52852289	52852289	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:52852289C>T	ENST00000266041.4	-	19	2259	c.2163G>A	c.(2161-2163)atG>atA	p.M721I	RP5-966M1.6_ENST00000468472.1_3'UTR|ITIH4_ENST00000406595.1_Missense_Mutation_p.M691I|ITIH4_ENST00000346281.5_Missense_Mutation_p.M691I|ITIH4_ENST00000485816.1_Missense_Mutation_p.M726I	NM_002218.4	NP_002209.2	Q14624	ITIH4_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 4	721					acute-phase response|hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(9)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		TTTGGGTTGTCATGGTTGTTT	0.592000													22	65					0	0	1	0	0
CNN3	1266	broad.mit.edu	37	1	95368702	95368702	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:95368702G>A	ENST00000370206.4	-	3	605	c.222C>T	c.(220-222)aaC>aaT	p.N74N	CNN3_ENST00000538964.1_Silent_p.N74N|CNN3_ENST00000545882.1_Silent_p.N33N|CNN3_ENST00000487539.1_5'UTR|CNN3_ENST00000394202.4_Silent_p.N74N	NM_001839.3	NP_001830.1	Q15417	CNN3_HUMAN	calponin 3, acidic	74	CH.				actomyosin structure organization|smooth muscle contraction		actin binding|calmodulin binding|tropomyosin binding|troponin C binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(9)|prostate(1)|stomach(1)|urinary_tract(2)	18		all_lung(203;0.00206)|Lung NSC(277;0.00948)		all cancers(265;0.0325)|Epithelial(280;0.0861)		GTGAGGACTCGTTGACCTTCT	0.403000													9	65					0	0	1	0	0
RMDN3	55177	broad.mit.edu	37	15	41029865	41029865	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr15:41029865G>A	ENST00000260385.6	-	9	2252	c.1185C>T	c.(1183-1185)ctC>ctT	p.L395L	RMDN3_ENST00000338376.3_Silent_p.L395L					regulator of microtubule dynamics 3									p.L395L(1)									CAGTGGCACTGAGAGGGCTTT	0.468000													26	84					0	0	1	0	0
FHDC1	85462	broad.mit.edu	37	4	153897386	153897386	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr4:153897386C>G	ENST00000511601.1	+	12	3131	c.2943C>G	c.(2941-2943)ttC>ttG	p.F981L	FHDC1_ENST00000260008.3_Missense_Mutation_p.F981L			Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	981					actin cytoskeleton organization		actin binding		ARFIP1/FHDC1(2)	NS(2)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	43	all_hematologic(180;0.093)					GGGGTTCTTTCAAGAAGCCCA	0.657000													12	29					0	0	1	0	0
C1orf112	55732	broad.mit.edu	37	1	169771854	169771854	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:169771854G>A	ENST00000286031.6	+	4	859	c.159G>A	c.(157-159)agG>agA	p.R53R	C1orf112_ENST00000456684.1_Silent_p.R111R|C1orf112_ENST00000413811.2_Silent_p.R24R|C1orf112_ENST00000359326.4_Silent_p.R53R|C1orf112_ENST00000498289.1_3'UTR	NM_018186.2	NP_060656.2	Q9NSG2	CA112_HUMAN	chromosome 1 open reading frame 112	53										breast(1)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(8)|lung(9)|ovary(1)|skin(1)|stomach(1)	34	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CCACTCTAAGGAATATTTTAC	0.338000													24	69					0	0	1	0	0
MCC	4163	broad.mit.edu	37	5	112363149	112363149	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr5:112363149C>G	ENST00000302475.4	-	17	2903	c.2340G>C	c.(2338-2340)aaG>aaC	p.K780N	MCC_ENST00000408903.3_Missense_Mutation_p.K970N|MCC_ENST00000515367.2_Missense_Mutation_p.K717N|MCC_ENST00000514701.3_5'UTR	NM_002387.2	NP_002378	P23508	CRCM_HUMAN	mutated in colorectal cancers	780					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			endometrium(4)|kidney(3)|large_intestine(15)|liver(2)|lung(8)|ovary(2)|pancreas(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		GATGCTTTTTCTTTGCTTTCT	0.453000													67	103					0	0	1	0	0
SLC8A1	6546	broad.mit.edu	37	2	40655747	40655747	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:40655747C>T	ENST00000406785.2	-	2	1863	c.1674G>A	c.(1672-1674)gtG>gtA	p.V558V	SLC8A1_ENST00000405269.1_Silent_p.V558V|SLC8A1_ENST00000542756.1_Silent_p.V558V|SLC8A1_ENST00000402441.1_Silent_p.V558V|SLC8A1_ENST00000332839.4_Silent_p.V558V|SLC8A1_ENST00000406391.2_Silent_p.V558V|SLC8A1_ENST00000403092.1_Silent_p.V558V|SLC8A1_ENST00000408028.2_Silent_p.V558V|SLC8A1_ENST00000405901.3_Silent_p.V558V|SLC8A1_ENST00000542024.1_Silent_p.V558V			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1		Calx-beta 2.				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	TCAATACTTTCACCTCCATGA	0.453000													56	112					0	0	1	0	0
KCNMB4	27345	broad.mit.edu	37	12	70794070	70794070	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr12:70794070G>C	ENST00000258111.4	+	2	877	c.418G>C	c.(418-420)Gag>Cag	p.E140Q		NM_014505.5	NP_055320.4	Q86W47	KCMB4_HUMAN	potassium large conductance calcium-activated channel, subfamily M, beta member 4	140					detection of calcium ion|platelet activation|regulation of action potential in neuron|regulation of neurotransmitter secretion|regulation of vasoconstriction|synaptic transmission	voltage-gated potassium channel complex	calcium-activated potassium channel activity|protein binding			kidney(1)|large_intestine(4)|lung(5)	10	Renal(347;0.236)		Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00243)|STAD - Stomach adenocarcinoma(21;0.0118)			CTGGAAAGATGAGATTGGTTC	0.363000													76	206					0	0	1	0	0
ZNF90	7643	broad.mit.edu	37	19	20229527	20229527	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:20229527G>C	ENST00000418063.2	+	4	1276	c.1164G>C	c.(1162-1164)aaG>aaC	p.K388N	ZNF90_ENST00000474284.1_Intron	NM_007138.1	NP_009069.1	Q03938	ZNF90_HUMAN	zinc finger protein 90	388						Golgi apparatus|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|lung(2)|ovary(1)|skin(1)	5						ATAAACATAAGATAAGTCATA	0.363000													20	37					0	0	1	0	0
NRAP	4892	broad.mit.edu	37	10	115402729	115402729	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr10:115402729G>C	ENST00000369358.4	-	12	1423	c.1179C>G	c.(1177-1179)ttC>ttG	p.F393L	NRAP_ENST00000359988.3_Missense_Mutation_p.F393L|NRAP_ENST00000360478.3_Intron|NRAP_ENST00000369360.3_Intron			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	393						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		TCACGTTCCTGAATTGAGGTG	0.408000													47	45					0	0	1	0	0
CCDC150	284992	broad.mit.edu	37	2	197540881	197540881	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:197540881G>C	ENST00000389175.4	+	11	1287	c.1152G>C	c.(1150-1152)atG>atC	p.M384I	CCDC150_ENST00000472405.2_3'UTR|CCDC150_ENST00000423093.2_Missense_Mutation_p.M52I|CCDC150_ENST00000272831.7_Missense_Mutation_p.M52I	NM_001080539.1	NP_001074008.1	Q8NCX0	CC150_HUMAN	coiled-coil domain containing 150	384										breast(3)|endometrium(6)|kidney(1)|large_intestine(6)|lung(14)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	33						AGCAGAAAATGATGACGCAGA	0.393000													41	65					0	0	1	0	0
PCK2	5106	broad.mit.edu	37	14	24567839	24567839	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr14:24567839G>A	ENST00000545054.2	+	4	1132	c.214G>A	c.(214-216)Gac>Aac	p.D72N	NRL_ENST00000561028.1_Intron|PCK2_ENST00000559250.1_Missense_Mutation_p.D218N|PCK2_ENST00000216780.4_Missense_Mutation_p.D206N|PCK2_ENST00000396973.4_Missense_Mutation_p.D206N|PCK2_ENST00000561286.1_Missense_Mutation_p.D72N|PCK2_ENST00000558096.1_Missense_Mutation_p.D72N			Q16822	PCKGM_HUMAN	phosphoenolpyruvate carboxykinase 2 (mitochondrial)	206					gluconeogenesis	mitochondrial matrix	GTP binding|metal ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			breast(2)|endometrium(2)|kidney(3)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	18				GBM - Glioblastoma multiforme(265;0.0184)		GGGAGATGGTGACTTTGTCAA	0.587000													16	20					0	0	1	0	0
FAM19A4	151647	broad.mit.edu	37	3	68802032	68802032	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:68802032G>C	ENST00000295569.7	-	4	760	c.268C>G	c.(268-270)Caa>Gaa	p.Q90E		NM_001005527.2|NM_182522.4	NP_001005527.1|NP_872328.1	Q96LR4	F19A4_HUMAN	family with sequence similarity 19 (chemokine (C-C motif)-like), member A4	90						extracellular region				haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(5)|skin(2)	10		Lung NSC(201;0.0198)		BRCA - Breast invasive adenocarcinoma(55;1.38e-05)|Epithelial(33;0.000124)|LUSC - Lung squamous cell carcinoma(21;0.0248)|KIRC - Kidney renal clear cell carcinoma(39;0.0729)|Kidney(39;0.0904)		CAAGAAGGTTGAGCCCGAGTT	0.517000													34	81					0	0	1	0	0
IL31RA	133396	broad.mit.edu	37	5	55195898	55195898	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr5:55195898C>A	ENST00000396834.1	+	10	1446	c.950C>A	c.(949-951)tCt>tAt	p.S317Y	IL31RA_ENST00000354961.4_Missense_Mutation_p.S317Y|IL31RA_ENST00000297015.3_Missense_Mutation_p.S194Y|IL31RA_ENST00000447346.2_Missense_Mutation_p.S336Y|IL31RA_ENST00000396836.2_Missense_Mutation_p.S336Y|IL31RA_ENST00000359040.5_Missense_Mutation_p.S336Y|IL31RA_ENST00000490985.1_Missense_Mutation_p.S194Y	NM_001242638.1	NP_001229567.1	Q8NI17	IL31R_HUMAN	interleukin 31 receptor A	304					anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			endometrium(2)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|stomach(1)	21		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)				TCTATGATTTCTTATAATTCT	0.443000													77	131					2.14232e-31	2.27685e-31	1	1	0
ST18	9705	broad.mit.edu	37	8	53025874	53025874	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr8:53025874C>T	ENST00000276480.7	-	26	3711	c.3028G>A	c.(3028-3030)Gaa>Aaa	p.E1010K		NM_014682.2	NP_055497.1	O60284	ST18_HUMAN	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	1010						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				ACATATGCTTCAAAATTCTGC	0.438000													57	109					0	0	1	0	0
FOXM1	2305	broad.mit.edu	37	12	2968012	2968012	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr12:2968012G>A	ENST00000342628.2	-	10	2311	c.2198C>T	c.(2197-2199)tCa>tTa	p.S733L	FOXM1_ENST00000361953.3_Missense_Mutation_p.S680L|FOXM1_ENST00000359843.3_Missense_Mutation_p.S695L|ITFG2_ENST00000545509.1_Intron	NM_202002.2	NP_973731.1	Q08050	FOXM1_HUMAN	forkhead box M1	695					cell cycle|embryo development|liver development|negative regulation of cell aging|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of cell growth|regulation of cell proliferation|regulation of oxygen and reactive oxygen species metabolic process|regulation of Ras protein signal transduction|regulation of reactive oxygen species metabolic process|regulation of sequence-specific DNA binding transcription factor activity|tissue development|transcription from RNA polymerase II promoter|vasculogenesis	cytoplasm|transcription factor complex	DNA bending activity|DNA binding|double-stranded DNA binding|promoter binding|protein binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|transcription factor binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(7)|lung(9)|prostate(1)|skin(1)|urinary_tract(3)	24			OV - Ovarian serous cystadenocarcinoma(31;0.000622)			GTCTATATCTGAGGGAGAAGA	0.557000													31	56					0	0	1	0	0
CCDC92	80212	broad.mit.edu	37	12	124422156	124422156	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr12:124422156C>G	ENST00000545135.1	-	3	3690	c.394G>C	c.(394-396)Gag>Cag	p.E132Q	CCDC92_ENST00000238156.3_Missense_Mutation_p.E149Q|CCDC92_ENST00000545891.1_Missense_Mutation_p.E132Q|CCDC92_ENST00000544798.1_Intron			Q53HC0	CCD92_HUMAN	coiled-coil domain containing 92	149										large_intestine(5)|lung(2)	7	all_neural(191;0.101)|Medulloblastoma(191;0.163)			Epithelial(86;0.0002)|OV - Ovarian serous cystadenocarcinoma(86;0.000222)|all cancers(50;0.00129)|BRCA - Breast invasive adenocarcinoma(302;0.242)		GCCCGCTGCTCCAGCTCGCTA	0.607000													39	89					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11607639	11607639	+	Silent	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr17:11607639C>G	ENST00000262442.4	+	25	5339	c.5271C>G	c.(5269-5271)ctC>ctG	p.L1757L	DNAH9_ENST00000454412.2_Silent_p.L1757L	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9		Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TGGCCCAGCTCAAAACCCTTA	0.512000													37	96					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39263784	39263784	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr13:39263784C>T	ENST00000280481.7	+	1	2519	c.2303C>T	c.(2302-2304)tCa>tTa	p.S768L		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	768					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GACAACCCCTCAGTCGTGGTG	0.547000													37	71					0	0	1	0	0
ADCK3	56997	broad.mit.edu	37	1	227170378	227170378	+	Splice_Site	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:227170378G>C	ENST00000366779.1	+	12	3624		c.e12-1		ADCK3_ENST00000478406.1_3'UTR|ADCK3_ENST00000366777.3_Splice_Site|ADCK3_ENST00000366778.1_Splice_Site|ADCK3_ENST00000458507.2_Splice_Site|ADCK3_ENST00000433743.2_Splice_Site			Q8NI60	ADCK3_HUMAN	aarF domain containing kinase 3						cell death	mitochondrion	ATP binding|protein serine/threonine kinase activity			endometrium(1)|kidney(2)|large_intestine(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	9						CTGCCTTCCAGATGATGCCTT	0.612000													22	88					0	0	1	0	0
BUB1	699	broad.mit.edu	37	2	111398939	111398939	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:111398939C>A	ENST00000535254.1	-	21	2735	c.2668G>T	c.(2668-2670)Gac>Tac	p.D890Y	BUB1_ENST00000302759.6_Missense_Mutation_p.D910Y|BUB1_ENST00000478175.1_5'UTR|BUB1_ENST00000409311.1_Intron	NM_001278616.1	NP_001265545.1	O43683	BUB1_HUMAN	BUB1 mitotic checkpoint serine/threonine kinase	910	Protein kinase.				apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			breast(3)|endometrium(8)|kidney(4)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|stomach(1)	45		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		ATTTCACAGTCATGCACTTGC	0.378000													61	79					2.5401e-28	2.69115e-28	1	1	0
SNX29	92017	broad.mit.edu	37	16	12172749	12172749	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr16:12172749C>T	ENST00000566228.1	+	11	1448	c.1379C>T	c.(1378-1380)tCa>tTa	p.S460L	SNX29_ENST00000306030.3_Missense_Mutation_p.S75L|SNX29_ENST00000323433.4_Missense_Mutation_p.S75L	NM_032167.3	NP_115543.3	Q8TEQ0	SNX29_HUMAN	sorting nexin 29	75					cell communication		phosphatidylinositol binding			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)	7						CCTTCTGCCTCAGTGCCAGAG	0.562000													11	5					0	0	1	0	0
ATP7A	538	broad.mit.edu	37	X	77301812	77301812	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chrX:77301812G>A	ENST00000341514.6	+	23	4403	c.4248G>A	c.(4246-4248)gaG>gaA	p.E1416E	ATP7A_ENST00000343533.5_Silent_p.E1338E|ATP7A_ENST00000350425.4_Silent_p.E419E	NM_000052.5	NP_000043.4	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	1416					ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity			breast(4)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(26)|pancreas(1)|prostate(1)|urinary_tract(1)	53						CAACTTACGAGAGTTATGAAC	0.408000													116	47					0	0	1	0	0
DNAJC13	23317	broad.mit.edu	37	3	132226195	132226195	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:132226195G>C	ENST00000260818.6	+	43	5361	c.5113G>C	c.(5113-5115)Gag>Cag	p.E1705Q		NM_015268.3	NP_056083.3	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	1705							heat shock protein binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|urinary_tract(1)	34						TTTCCAACTGGAGGTAAGCTC	0.338000													58	128					0	0	1	0	0
MANEA	79694	broad.mit.edu	37	6	96034700	96034700	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr6:96034700G>C	ENST00000358812.4	+	2	519	c.385G>C	c.(385-387)Gag>Cag	p.E129Q	MANEA_ENST00000369293.1_Missense_Mutation_p.E129Q	NM_024641.3	NP_078917.2	Q5SRI9	MANEA_HUMAN	mannosidase, endo-alpha	129	Catalytic (Probable).			E -> G (in Ref. 4; CAD97640).	post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	glycoprotein endo-alpha-1,2-mannosidase activity			breast(2)|endometrium(3)|kidney(2)|liver(2)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	26		all_cancers(76;1.01e-06)|Acute lymphoblastic leukemia(125;3.58e-09)|all_hematologic(75;1.22e-06)|all_epithelial(107;0.00433)|Colorectal(196;0.0341)		BRCA - Breast invasive adenocarcinoma(108;0.148)		TCCAGTGTTAGAGCATTGGGA	0.388000													65	116					0	0	1	0	0
HMHA1	23526	broad.mit.edu	37	19	1081901	1081901	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:1081901G>A	ENST00000313093.2	+	19	2689	c.2458G>A	c.(2458-2460)Gag>Aag	p.E820K	HMHA1_ENST00000586866.1_Missense_Mutation_p.E824K|HMHA1_ENST00000590577.1_Missense_Mutation_p.E455K|HMHA1_ENST00000543365.1_Missense_Mutation_p.E703K|HMHA1_ENST00000590214.1_Missense_Mutation_p.E847K|HMHA1_ENST00000539243.2_Missense_Mutation_p.E836K|HMHA1_ENST00000536472.1_Missense_Mutation_p.E688K	NM_012292.3	NP_036424.2	Q92619	HMHA1_HUMAN	histocompatibility (minor) HA-1	820	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|lung(7)|ovary(1)|prostate(2)	16		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAGCTGGTCGAGCTGTCGCA	0.662000													14	13					0	0	1	0	0
SNHG12	85028	broad.mit.edu	37	1	28907554	28907554	+	RNA	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:28907554G>C	ENST00000488745.1	-	0	1013				SNHG12_ENST00000475441.1_RNA|SNHG12_ENST00000531126.1_RNA|SNHG12_ENST00000483436.1_RNA|SNHG12_ENST00000384342.1_RNA																							CTGCAGCTTCGATAAGGGCCA	0.532000													62	68					0	0	1	0	0
C10orf120	399814	broad.mit.edu	37	10	124457657	124457657	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr10:124457657C>T	ENST00000329446.4	-	3	631	c.600G>A	c.(598-600)ctG>ctA	p.L200L		NM_001010912.1	NP_001010912.1	Q5SQS8	CJ120_HUMAN	chromosome 10 open reading frame 120	200										endometrium(1)|kidney(1)|large_intestine(6)|lung(9)|skin(2)|stomach(1)|urinary_tract(1)	21		all_neural(114;0.169)|Glioma(114;0.222)				CCATTGGACCCAGGCCCACCC	0.478000													52	27					0	0	1	0	0
DISP2	85455	broad.mit.edu	37	15	40660725	40660725	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr15:40660725C>T	ENST00000267889.3	+	8	2499	c.2412C>T	c.(2410-2412)agC>agT	p.S804S		NM_033510.1	NP_277045.1	A7MBM2	DISP2_HUMAN	dispatched homolog 2 (Drosophila)	804					smoothened signaling pathway	integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(12)|ovary(4)	30		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		TCTCGGCCAGCGGCCCTGAGG	0.667000													39	70					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24885223	24885223	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr14:24885223C>T	ENST00000382554.3	+	9	4586	c.4268C>T	c.(4267-4269)tCc>tTc	p.S1423F		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	1423					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						GGCCTCTCATCCCTTCCGTTT	0.622000													27	95					0	0	1	0	0
ELAVL4	1996	broad.mit.edu	37	1	50661353	50661353	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:50661353C>T	ENST00000371824.1	+	5	886	c.629C>T	c.(628-630)gCc>gTc	p.A210V	ELAVL4_ENST00000357083.4_Missense_Mutation_p.A227V|ELAVL4_ENST00000371827.1_Missense_Mutation_p.A210V|ELAVL4_ENST00000448907.2_Missense_Mutation_p.A213V|ELAVL4_ENST00000371819.1_Missense_Mutation_p.A215V|ELAVL4_ENST00000371823.4_Missense_Mutation_p.A210V|ELAVL4_ENST00000371821.1_Missense_Mutation_p.A215V			P26378	ELAV4_HUMAN	ELAV like neuron-specific RNA binding protein 4	210	RRM 2.				mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			NS(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|liver(2)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	32						GTGAAGTTTGCCAACAACCCC	0.577000													4	93					0	0	1	0	0
TAS1R3	83756	broad.mit.edu	37	1	1266782	1266782	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:1266782G>A	ENST00000339381.5	+	1	89	c.57G>A	c.(55-57)acG>acA	p.T19T		NM_152228.1	NP_689414	Q7RTX0	TS1R3_HUMAN	taste receptor, type 1, member 3	19					detection of chemical stimulus involved in sensory perception of sweet taste|sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			kidney(2)|lung(8)|upper_aerodigestive_tract(1)|urinary_tract(1)	12	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.88e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.146)	Aspartame(DB00168)	ACCCTGGGACGGGGGCCCCAT	0.687000													13	34					0	0	1	0	0
CLEC4D	338339	broad.mit.edu	37	12	8672847	8672847	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr12:8672847G>A	ENST00000299665.2	+	5	603	c.410G>A	c.(409-411)aGa>aAa	p.R137K		NM_080387.4	NP_525126.2	Q8WXI8	CLC4D_HUMAN	C-type lectin domain family 4, member D	137	C-type lectin.				innate immune response	integral to membrane	sugar binding	p.R137K(1)		large_intestine(4)|lung(6)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	14	Lung SC(5;0.184)					TTTCTGGATAGACGGCTTTCC	0.383000													34	55					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113518601	113518601	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr7:113518601G>T	ENST00000284601.3	-	4	2614	c.2546C>A	c.(2545-2547)tCa>tAa	p.S849*		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	849					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						AATGACCCATGAGGATTCTTC	0.373000													71	107					5.61366e-43	6.01337e-43	1	1	0
GALR2	8811	broad.mit.edu	37	17	74073168	74073168	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr17:74073168C>T	ENST00000329003.3	+	2	910	c.820C>T	c.(820-822)Cgc>Tgc	p.R274C		NM_003857.2	NP_003848.1	O43603	GALR2_HUMAN	galanin receptor 2	274					digestion|elevation of cytosolic calcium ion concentration|feeding behavior|learning or memory|muscle contraction	integral to membrane|plasma membrane	galanin receptor activity			cervix(1)|lung(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	8						TTATGCGCTTCGCATCCTCTC	0.637000													15	21					0	0	1	0	0
SOX10	6663	broad.mit.edu	37	22	38369569	38369569	+	Nonsense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr22:38369569G>C	ENST00000396884.2	-	4	1616	c.1334C>G	c.(1333-1335)tCa>tGa	p.S445*	SOX10_ENST00000360880.2_Nonsense_Mutation_p.S445*|POLR2F_ENST00000407936.1_Intron|POLR2F_ENST00000405557.1_Intron	NM_006941.3	NP_008872.1	P56693	SOX10_HUMAN	SRY (sex determining region Y)-box 10	445						cytoplasm|nucleus	DNA binding|identical protein binding|transcription coactivator activity			NS(6)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(4)|skin(2)	20	Melanoma(58;0.045)					CTGGGGCCCTGAGGGGCTGGG	0.682000													22	16					0	0	1	0	0
HELZ	9931	broad.mit.edu	37	17	65141988	65141988	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr17:65141988G>A	ENST00000358691.5	-	21	2806	c.2640C>T	c.(2638-2640)ttC>ttT	p.F880F	HELZ_ENST00000580168.1_Silent_p.F881F	NM_014877.3	NP_055692			helicase with zinc finger											NS(1)|breast(5)|endometrium(9)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					TGCCCTCATAGAAAAGCTCAG	0.373000													32	50					0	0	1	0	0
ZNF814	730051	broad.mit.edu	37	19	58385546	58385546	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:58385546G>T	ENST00000435989.2	-	3	1446	c.1212C>A	c.(1210-1212)gaC>gaA	p.D404E	ZNF814_ENST00000595295.1_Intron|ZNF814_ENST00000600634.1_Intron|ZNF814_ENST00000597342.1_Intron|ZNF814_ENST00000596604.1_Intron|ZNF814_ENST00000597832.1_Intron	NM_001144989.1	NP_001138461.1	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	404					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.D404E(10)		NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						AATGTTTTTTGTCAGTGTGAA	0.393000													5	17					0.014758	0.0148017	1	1	0
ADH7	131	broad.mit.edu	37	4	100350703	100350703	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr4:100350703C>T	ENST00000437033.2	-	2	609	c.106G>A	c.(106-108)Gaa>Aaa	p.E36K	ADH7_ENST00000482593.1_5'UTR|ADH7_ENST00000476959.1_Missense_Mutation_p.E56K|ADH7_ENST00000209665.4_Missense_Mutation_p.E48K			P40394	ADH7_HUMAN	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide	48					ethanol oxidation|fatty acid omega-oxidation|response to bacterium|response to ethanol|xenobiotic metabolic process	cytosol|soluble fraction	alcohol dehydrogenase activity, zinc-dependent|aldehyde oxidase activity|ethanol binding|receptor antagonist activity|retinol binding|retinol dehydrogenase activity			breast(1)|central_nervous_system(2)|large_intestine(4)|lung(11)|skin(1)	19				OV - Ovarian serous cystadenocarcinoma(123;1.75e-08)	NADH(DB00157)	ATGCGAACTTCTTTAGTCTTT	0.408000													19	35					0	0	1	0	0
PNPLA3	80339	broad.mit.edu	37	22	44319842	44319842	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr22:44319842C>A	ENST00000216180.3	+	1	224	c.51C>A	c.(49-51)ttC>ttA	p.F17L	PNPLA3_ENST00000423180.2_Missense_Mutation_p.F17L	NM_025225.2	NP_079501.2	Q9NST1	PLPL3_HUMAN	patatin-like phospholipase domain containing 3	17	Patatin.				triglyceride biosynthetic process|triglyceride catabolic process	integral to membrane	diolein transacylation activity|mono-olein transacylation activity|phospholipase A2 activity|triglyceride lipase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(3)|prostate(1)|skin(1)|stomach(2)	19		Ovarian(80;0.024)|all_neural(38;0.0416)				GCTGCGGCTTCCTGGGCTTCT	0.741000													12	5					0.00136819	0.00137428	1	1	0
ADAM21P1	145241	broad.mit.edu	37	14	70712772	70712772	+	RNA	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr14:70712772G>A	ENST00000530196.1	-	0	1746					NR_003951.1																						CGGTTTCCCTGAGAGTTGATT	0.383000													44	205					0	0	1	0	0
FUNDC2P2	388965	broad.mit.edu	37	2	84517923	84517923	+	RNA	SNP	C	C	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:84517923C>A	ENST00000331369.5	+	0	117																											CGTGTGTCCTCGCAAGACTAG	0.587000													12	29					3.07112e-06	3.09397e-06	1	1	0
HID1	283987	broad.mit.edu	37	17	72959943	72959943	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr17:72959943G>A	ENST00000425042.2	-	3	356	c.279C>T	c.(277-279)atC>atT	p.I93I	HID1_ENST00000532900.1_5'UTR	NM_030630.2	NP_085133.1			HID1 domain containing																		AGTTCAGGACGATCTGCTTCT	0.657000													35	52					0	0	1	0	0
GPR179	440435	broad.mit.edu	37	17	36499513	36499513	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr17:36499513C>T	ENST00000342292.4	-	1	180	c.160G>A	c.(160-162)Gag>Aag	p.E54K		NM_001004334.2	NP_001004334.2	Q6PRD1	GP179_HUMAN	G protein-coupled receptor 179	54						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(4)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(16)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				TCGGCCCCCTCTAGGGGCACC	0.632000													26	56					0	0	1	0	0
DBN1	1627	broad.mit.edu	37	5	176887463	176887463	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr5:176887463C>A	ENST00000292385.5	-	11	1540	c.931G>T	c.(931-933)Gat>Tat	p.D311Y	DBN1_ENST00000393563.4_Missense_Mutation_p.D41Y|DBN1_ENST00000512501.1_Missense_Mutation_p.D41Y|DBN1_ENST00000309007.5_Missense_Mutation_p.D309Y|DBN1_ENST00000393565.1_Missense_Mutation_p.D309Y	NM_080881.2	NP_543157	Q16643	DREB_HUMAN	drebrin 1	309					actin filament organization|regulation of dendrite development|regulation of neuronal synaptic plasticity	actomyosin|cytoplasm|dendrite	actin binding|profilin binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(12)|ovary(1)|skin(2)	25	all_cancers(89;2.17e-05)|Renal(175;0.000269)|Lung NSC(126;0.0014)|all_lung(126;0.0025)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GAGGGTACATCACAGCTGCCC	0.632000													84	119					8.2577e-42	8.8317e-42	1	1	0
PPP1R12A	4659	broad.mit.edu	37	12	80200099	80200099	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr12:80200099C>T	ENST00000450142.2	-	13	1936	c.1670G>A	c.(1669-1671)aGa>aAa	p.R557K	PPP1R12A_ENST00000261207.5_Missense_Mutation_p.R557K|AC073569.1_ENST00000598624.1_Intron|PPP1R12A_ENST00000550107.1_Intron|PPP1R12A_ENST00000437004.2_Missense_Mutation_p.R557K|PPP1R12A_ENST00000546369.1_Missense_Mutation_p.R470K	NM_002480.2	NP_002471.1	O14974	MYPT1_HUMAN	protein phosphatase 1, regulatory subunit 12A	557	Ser/Thr-rich.					contractile fiber	protein binding|signal transducer activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(7)|liver(1)|lung(4)|ovary(2)|skin(1)	29						ATCTTGTCTTCTACCAAAGGA	0.368000													39	156					0	0	1	0	0
C17orf77	146723	broad.mit.edu	37	17	72588299	72588299	+	Silent	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr17:72588299C>G	ENST00000392620.1	+	3	476	c.114C>G	c.(112-114)ctC>ctG	p.L38L	C17orf77_ENST00000328023.2_Silent_p.L38L|CD300LD_ENST00000375352.1_Intron	NM_152460.2	NP_689673.2	Q96MU5	CQ077_HUMAN	chromosome 17 open reading frame 77	38						extracellular region				breast(2)|large_intestine(2)|lung(5)|prostate(1)|stomach(1)	11						CAGCCACACTCACCTGGGAGG	0.562000													33	68					0	0	1	0	0
USP21	27005	broad.mit.edu	37	1	161130470	161130470	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:161130470G>C	ENST00000368002.3	+	3	417	c.40G>C	c.(40-42)Gag>Cag	p.E14Q	USP21_ENST00000289865.8_Missense_Mutation_p.E14Q|USP21_ENST00000368001.1_Missense_Mutation_p.E14Q	NM_001014443.2	NP_001014443.1	Q9UK80	UBP21_HUMAN	ubiquitin specific peptidase 21	14					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding|NEDD8-specific protease activity|protein binding|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(10)|ovary(3)|prostate(3)	29	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			CCGTACCCGAGAGCCACCTGT	0.622000													28	87					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62285506	62285506	+	Silent	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr11:62285506C>G	ENST00000378024.4	-	5	16657	c.16383G>C	c.(16381-16383)gtG>gtC	p.V5461V	AHNAK_ENST00000530124.1_Intron|AHNAK_ENST00000257247.7_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	5461	Gly-rich.				nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				GGCTCCCTTTCACTTTTGGTC	0.542000													73	92					0	0	1	0	0
LATS1	9113	broad.mit.edu	37	6	150004798	150004798	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr6:150004798G>A	ENST00000543571.1	-	4	1974	c.1427C>T	c.(1426-1428)tCt>tTt	p.S476F	LATS1_ENST00000542747.1_5'UTR|LATS1_ENST00000253339.5_Missense_Mutation_p.S476F|LATS1_ENST00000392273.3_Missense_Mutation_p.S476F	NM_004690.3	NP_004681.1	O95835	LATS1_HUMAN	large tumor suppressor kinase 1	476					cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			central_nervous_system(1)|lung(5)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		AGAATTAGCAGAGTGACTTGC	0.433000													116	215					0	0	1	0	0
TEPP	374739	broad.mit.edu	37	16	58018651	58018651	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr16:58018651G>C	ENST00000290871.5	+	4	599	c.562G>C	c.(562-564)Gag>Cag	p.E188Q	TEPP_ENST00000441824.2_Missense_Mutation_p.E188Q|TEPP_ENST00000569996.1_3'UTR	NM_199046.2	NP_950247.2	Q6URK8	TEPP_HUMAN	testis, prostate and placenta expressed	188						extracellular region				central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(3)|skin(1)|urinary_tract(1)	8						GCGCGCCATCGAGGACTGGTC	0.652000													5	2					0	0	1	0	0
RIPK3	11035	broad.mit.edu	37	14	24806655	24806655	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr14:24806655G>A	ENST00000216274.5	-	8	1130	c.912C>T	c.(910-912)ttC>ttT	p.F304F		NM_006871.3	NP_006862.2	Q9Y572	RIPK3_HUMAN	receptor-interacting serine-threonine kinase 3	304					apoptosis|induction of apoptosis by extracellular signals	cytoplasm	ATP binding|protein binding|transcription coactivator activity			NS(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(4)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23				GBM - Glioblastoma multiforme(265;0.0181)		GCTGAGACAGGAAATCCTTTA	0.493000													85	234					0	0	1	0	0
ACE	1636	broad.mit.edu	37	17	61560498	61560498	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr17:61560498C>A	ENST00000290866.4	+	9	1475	c.1451C>A	c.(1450-1452)cCc>cAc	p.P484H	ACE_ENST00000428043.1_Missense_Mutation_p.P484H|ACE_ENST00000538928.1_Intron|ACE_ENST00000584529.1_Intron	NM_000789.3	NP_000780.1	P12821	ACE_HUMAN	angiotensin I converting enzyme	484	Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(3)|lung(22)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	51					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	GGGCGTACCCCCCCTTCCCGC	0.562000													103	164					1.48543e-65	1.60388e-65	1	1	0
SLC35C2	51006	broad.mit.edu	37	20	44986356	44986356	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr20:44986356G>C	ENST00000372227.1	-	3	717	c.177C>G	c.(175-177)ttC>ttG	p.F59L	SLC35C2_ENST00000317734.8_Missense_Mutation_p.F59L|SLC35C2_ENST00000372229.1_Intron|SLC35C2_ENST00000243896.2_Missense_Mutation_p.F59L|SLC35C2_ENST00000372230.5_Missense_Mutation_p.F59L|SLC35C2_ENST00000543605.1_Missense_Mutation_p.F88L	NM_001281458.1|NM_001281460.1	NP_001268387.1|NP_001268389.1	Q9NQQ7	S35C2_HUMAN	solute carrier family 35 (GDP-fucose transporter), member C2	59					transport	integral to membrane				cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)	16		Myeloproliferative disorder(115;0.0122)				ACAGGGCGGAGAAGAGGAAGA	0.607000													27	74					0	0	1	0	0
DDB1	1642	broad.mit.edu	37	11	61083760	61083760	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr11:61083760G>C	ENST00000301764.7	-	12	1804	c.1407C>G	c.(1405-1407)atC>atG	p.I469M	DDB1_ENST00000450997.2_Intron|DDB1_ENST00000545930.1_5'UTR	NM_001923.4	NP_001914.3	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1, 127kDa	469	Interaction with CDT1.|Interaction with CUL4A.				cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	48						TTATCACCTGGATAAGCTGCT	0.433000								Nucleotide excision repair (NER)					119	256					0	0	1	0	0
ANKRD50	57182	broad.mit.edu	37	4	125590361	125590361	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr4:125590361C>G	ENST00000504087.1	-	4	5108	c.4071G>C	c.(4069-4071)aaG>aaC	p.K1357N	ANKRD50_ENST00000515641.1_Missense_Mutation_p.K1178N	NM_020337.2	NP_065070.1	Q9ULJ7	ANR50_HUMAN	ankyrin repeat domain 50	1357										NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(14)|lung(18)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	55						TTCCATTTCTCTTCTTCTGTT	0.403000													49	132					0	0	1	0	0
STK11IP	114790	broad.mit.edu	37	2	220479221	220479221	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:220479221C>T	ENST00000456909.1	+	23	2912	c.2822C>T	c.(2821-2823)tCc>tTc	p.S941F	STK11IP_ENST00000295641.10_Missense_Mutation_p.S952F			Q8N1F8	S11IP_HUMAN	serine/threonine kinase 11 interacting protein	952					protein localization	cytoplasm	protein kinase binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|urinary_tract(1)	23		Renal(207;0.0183)		Epithelial(149;2.69e-07)|all cancers(144;5.91e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AAAGACTCATCCTTGGAGGCT	0.542000													20	17					0	0	1	0	0
EGF	1950	broad.mit.edu	37	4	110932475	110932475	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr4:110932475G>A	ENST00000265171.5	+	24	3933	c.3488G>A	c.(3487-3489)cGa>cAa	p.R1163Q	EGF_ENST00000503392.1_Missense_Mutation_p.R1122Q|EGF_ENST00000509793.1_Missense_Mutation_p.R1121Q	NM_001178130.1|NM_001963.4	NP_001171601.1|NP_001954.2	P01133	EGF_HUMAN	epidermal growth factor	1163					angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			breast(1)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	GTAATGGAGCGAAGCTTTCAT	0.542000													39	74					0	0	1	0	0
SUN5	140732	broad.mit.edu	37	20	31571699	31571699	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr20:31571699C>T	ENST00000356173.3	-	13	1133	c.1041G>A	c.(1039-1041)ggG>ggA	p.G347G	SUN5_ENST00000375523.3_Silent_p.G322G	NM_080675.3	NP_542406.2	Q8TC36	SUN5_HUMAN	Sad1 and UNC84 domain containing 5	347	SUN.				spermatogenesis					endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	25						AGCCTGGGTTCCCCCAGTTGC	0.587000													62	111					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7667185	7667185	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr17:7667185G>C	ENST00000572933.1	+	19	4475	c.3015G>C	c.(3013-3015)gaG>gaC	p.E1005D	DNAH2_ENST00000389173.2_Missense_Mutation_p.E1005D			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	1005	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				AGAAGGAGGAGACAGTCACCA	0.522000													47	90					0	0	1	0	0
CD209	30835	broad.mit.edu	37	19	7809086	7809086	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:7809086G>C	ENST00000315599.7	-	6	942	c.920C>G	c.(919-921)tCt>tGt	p.S307C	CD209_ENST00000394173.4_Missense_Mutation_p.S146C|CD209_ENST00000601951.1_Missense_Mutation_p.S283C|CD209_ENST00000394161.5_Intron|CD209_ENST00000354397.6_Splice_Site_p.S301C|CD209_ENST00000593660.1_Missense_Mutation_p.S237C|CD209_ENST00000204801.8_Missense_Mutation_p.S263C|CD209_ENST00000315591.8_Missense_Mutation_p.S283C|CD209_ENST00000593821.1_Missense_Mutation_p.S171C|CD209_ENST00000601256.1_Intron|CD209_ENST00000602261.1_Missense_Mutation_p.S215C|CD209_ENST00000301357.8_Missense_Mutation_p.S171C	NM_001144895.1|NM_001144897.1|NM_021155.3	NP_001138367.1|NP_001138369.1|NP_066978.1	Q9NNX6	CD209_HUMAN	CD209 molecule	307	C-type lectin.				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding			endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						ACTTCTGGAAGACTGCAGCTG	0.537000													40	66					0	0	1	0	0
PITRM1	10531	broad.mit.edu	37	10	3180444	3180444	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr10:3180444G>A	ENST00000380989.2	-	26	3044	c.3006C>T	c.(3004-3006)ctC>ctT	p.L1002L	PITRM1_ENST00000224949.4_Silent_p.L1001L|PITRM1_ENST00000464395.1_5'UTR|PITRM1_ENST00000451104.2_Silent_p.L903L|PITRM1_ENST00000380994.1_Silent_p.L559L	NM_001242307.1|NM_014889.3	NP_001229236.1|NP_055704.2	E7ES23	E7ES23_HUMAN	pitrilysin metallopeptidase 1	903					proteolysis		metalloendopeptidase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(5)|liver(1)|lung(5)|ovary(1)|pancreas(1)|prostate(4)|skin(1)|stomach(2)|urinary_tract(3)	33						TCACGGCCAGGAGCTTGTCGT	0.587000													25	49					0	0	1	0	0
TNIK	23043	broad.mit.edu	37	3	170828529	170828529	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:170828529C>T	ENST00000436636.2	-	19	2602	c.2258G>A	c.(2257-2259)gGa>gAa	p.G753E	TNIK_ENST00000475336.1_Missense_Mutation_p.G669E|TNIK_ENST00000357327.5_Missense_Mutation_p.G724E|TNIK_ENST00000341852.6_Missense_Mutation_p.G669E|TNIK_ENST00000460047.1_Missense_Mutation_p.G698E|TNIK_ENST00000538048.1_Missense_Mutation_p.G698E|TNIK_ENST00000488470.1_Missense_Mutation_p.G698E|TNIK_ENST00000284483.8_Missense_Mutation_p.G753E|TNIK_ENST00000470834.1_Missense_Mutation_p.G724E|TNIK_ENST00000369326.5_Missense_Mutation_p.G724E	NM_015028.2	NP_055843.1	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase	753	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(22)|ovary(5)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)	62	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			TTCACTGGATCCTGCTTGTGA	0.557000													6	6					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38793964	38793964	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:38793964G>A	ENST00000449082.2	-	11	1500	c.1501C>T	c.(1501-1503)Cat>Tat	p.H501Y		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	501					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	ACACTGCCATGACTAGCCCGG	0.557000													16	22					0	0	1	0	0
LIPT1	51601	broad.mit.edu	37	2	99778643	99778643	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:99778643G>C	ENST00000393477.3	+	4	575	c.223G>C	c.(223-225)Ggt>Cgt	p.G75R	LIPT1_ENST00000393474.3_Missense_Mutation_p.G75R|MRPL30_ENST00000410042.1_Intron|LIPT1_ENST00000393473.2_Missense_Mutation_p.G75R|LIPT1_ENST00000340066.1_Missense_Mutation_p.G75R|LIPT1_ENST00000393471.2_Missense_Mutation_p.G75R	NM_145197.2	NP_660198.1	Q9Y234	LIPT_HUMAN	lipoyltransferase 1	75					lipid metabolic process|protein lipoylation	mitochondrion	acyltransferase activity			large_intestine(6)|lung(1)	7					Lipoic Acid(DB00166)	TGTTGTAATTGGTAGGCATCA	0.418000													76	105					0	0	1	0	0
PPAPDC3	84814	broad.mit.edu	37	9	134165483	134165483	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr9:134165483G>A	ENST00000372264.3	+	1	403	c.99G>A	c.(97-99)ccG>ccA	p.P33P	PPAPDC3_ENST00000372261.1_Silent_p.P33P	NM_032728.3	NP_116117.3	Q8NBV4	PPAC3_HUMAN	phosphatidic acid phosphatase type 2 domain containing 3	33						endoplasmic reticulum membrane|integral to membrane|nuclear envelope	hydrolase activity			breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(9)|skin(1)	16	all_hematologic(7;0.0119)			OV - Ovarian serous cystadenocarcinoma(145;1.22e-05)|Epithelial(140;0.000173)		AGGGGGGCCCGGAGCCCCGCA	0.711000													15	26					0	0	1	0	0
C1QTNF1	114897	broad.mit.edu	37	17	77044007	77044007	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr17:77044007G>A	ENST00000339142.2	+	5	1238	c.683G>A	c.(682-684)cGc>cAc	p.R228H	C1QTNF1_ENST00000580454.1_Missense_Mutation_p.R228H|C1QTNF1_ENST00000583904.1_Missense_Mutation_p.R228H|C1QTNF1_ENST00000392445.2_Missense_Mutation_p.R228H|C1QTNF1_ENST00000311661.4_Missense_Mutation_p.R146H|C1QTNF1_ENST00000582625.1_3'UTR|C1QTNF1_ENST00000581774.1_Missense_Mutation_p.R228H|C1QTNF1_ENST00000579760.1_Missense_Mutation_p.R228H|C1QTNF1_ENST00000578229.1_Missense_Mutation_p.R146H|C1QTNF1_ENST00000580474.1_Missense_Mutation_p.R228H|C1QTNF1_ENST00000354124.3_Missense_Mutation_p.R238H	NM_198593.3	NP_940995.1	Q9BXJ1	C1QT1_HUMAN	C1q and tumor necrosis factor related protein 1	228	C1q.					collagen				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|ovary(2)	14			BRCA - Breast invasive adenocarcinoma(99;0.0294)|OV - Ovarian serous cystadenocarcinoma(97;0.201)			GTGGGCGACCGCAGCATCATG	0.582000													32	48					0	0	1	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64601703	64601703	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:64601703G>T	ENST00000498707.1	-	20	3299	c.2957C>A	c.(2956-2958)cCa>cAa	p.P986Q	ADAMTS9_ENST00000295903.4_Missense_Mutation_p.P958Q	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	986	TSP type-1 3.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		ACGGTTGCTTGGTTTGGGATG	0.493000													169	236					6.98292e-63	7.52777e-63	1	1	0
ANKRD30A	91074	broad.mit.edu	37	10	37447345	37447345	+	Silent	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr10:37447345G>C	ENST00000374660.1	+	14	1755	c.1656G>C	c.(1654-1656)ctG>ctC	p.L552L	ANKRD30A_ENST00000361713.1_Silent_p.L552L|ANKRD30A_ENST00000602533.1_Silent_p.L552L			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	608						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						ATGGTCTTCTGAAGGTAATAA	0.308000													60	117					0	0	1	0	0
TUBGCP5	114791	broad.mit.edu	37	15	22864359	22864359	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr15:22864359G>C	ENST00000283645.4	+	16	2447	c.2317G>C	c.(2317-2319)Gat>Cat	p.D773H	TUBGCP5_ENST00000453949.2_Missense_Mutation_p.D773H	NM_052903.4	NP_443135.3	Q96RT8	GCP5_HUMAN	tubulin, gamma complex associated protein 5	773					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(5)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(23)|prostate(1)|skin(2)|urinary_tract(1)	46		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.86e-06)|Epithelial(43;2.63e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000949)		TTATCCTGAAGATAGTTCACG	0.343000													26	64					0	0	1	0	0
KRT6A	3853	broad.mit.edu	37	12	52884379	52884379	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr12:52884379C>T	ENST00000330722.6	-	5	1119	c.1051G>A	c.(1051-1053)Gag>Aag	p.E351K		NM_005554.3	NP_005545.1	P02538	K2C6A_HUMAN	keratin 6A	351	Coil 2.|Rod.				cell differentiation|ectoderm development|positive regulation of cell proliferation	keratin filament	protein binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|liver(1)|lung(14)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	39				BRCA - Breast invasive adenocarcinoma(357;0.189)		GACTCAGCCTCAGCCCGGCTT	0.572000													109	184					0	0	1	0	0
CCDC82	79780	broad.mit.edu	37	11	96092326	96092326	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr11:96092326C>G	ENST00000278520.5	-	8	1825	c.1397G>C	c.(1396-1398)aGa>aCa	p.R466T	CCDC82_ENST00000542662.1_Missense_Mutation_p.R466T|CCDC82_ENST00000423339.2_Missense_Mutation_p.R466T			Q8N4S0	CCD82_HUMAN	coiled-coil domain containing 82	466							protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)	19		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)		BRCA - Breast invasive adenocarcinoma(274;0.154)		GGCACAAATTCTGCCAACAGT	0.323000													22	20					0	0	1	0	0
KSR1	8844	broad.mit.edu	37	17	25950446	25950446	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr17:25950446C>G	ENST00000578981.1	+	2	346	c.168C>G	c.(166-168)atC>atG	p.I56M	KSR1_ENST00000319524.6_3'UTR|KSR1_ENST00000582410.1_3'UTR|KSR1_ENST00000398988.3_3'UTR|AC015688.3_ENST00000584605.1_Missense_Mutation_p.I19M			Q8IVT5	KSR1_HUMAN	kinase suppressor of ras 1	0					Ras protein signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(12)|prostate(2)|urinary_tract(1)	28	Lung NSC(42;0.00836)		BRCA - Breast invasive adenocarcinoma(3;0.00122)	UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		CGCTGCTGATCTCTTTCTTTT	0.478000													17	22					0	0	1	0	0
LATS1	9113	broad.mit.edu	37	6	150004840	150004840	+	Nonsense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr6:150004840G>C	ENST00000543571.1	-	4	1932	c.1385C>G	c.(1384-1386)tCa>tGa	p.S462*	LATS1_ENST00000542747.1_5'UTR|LATS1_ENST00000253339.5_Nonsense_Mutation_p.S462*|LATS1_ENST00000392273.3_Nonsense_Mutation_p.S462*	NM_004690.3	NP_004681.1	O95835	LATS1_HUMAN	large tumor suppressor kinase 1	462					cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			central_nervous_system(1)|lung(5)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		AAAAGAATTTGACCTCACTGG	0.453000													125	249					0	0	1	0	0
HSPB9	94086	broad.mit.edu	37	17	40275082	40275082	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr17:40275082G>A	ENST00000355067.3	+	1	327	c.214G>A	c.(214-216)Gtg>Atg	p.V72M	CTD-2132N18.3_ENST00000592574.1_Intron	NM_033194.2	NP_149971.1	Q9BQS6	HSPB9_HUMAN	heat shock protein, alpha-crystallin-related, B9	72					response to stress	cytoplasm|nucleus	protein binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)	4		all_cancers(22;0.00064)|Breast(137;0.00104)|all_epithelial(22;0.00866)		BRCA - Breast invasive adenocarcinoma(366;0.124)		GGTGGTGCAGGTGGATGGCCA	0.592000													47	97					0	0	1	0	0
ACRC	93953	broad.mit.edu	37	X	70823810	70823810	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chrX:70823810G>A	ENST00000373695.1	+	7	1220	c.683G>A	c.(682-684)aGc>aAc	p.S228N	ACRC_ENST00000373696.3_Missense_Mutation_p.S228N			Q96QF7	ACRC_HUMAN	acidic repeat containing	228	Asp/Ser-rich.					nucleus				autonomic_ganglia(1)|breast(1)|endometrium(15)|kidney(4)|large_intestine(4)|lung(20)|ovary(5)|prostate(1)|skin(2)|stomach(1)	54	Renal(35;0.156)					CCCGACGACAGCAGTGATGAT	0.517000													7	419					0	0	1	0	0
SLC2A7	155184	broad.mit.edu	37	1	9083072	9083072	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:9083072G>A	ENST00000400906.1	-	3	215	c.216C>T	c.(214-216)ctC>ctT	p.L72L		NM_207420.2	NP_997303.2	Q6PXP3	GTR7_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 7	72						integral to membrane|plasma membrane	sugar transmembrane transporter activity			NS(1)|breast(1)|endometrium(4)|large_intestine(10)|lung(4)|prostate(2)|skin(2)	24	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.04e-07)|COAD - Colon adenocarcinoma(227;7.66e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00177)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|READ - Rectum adenocarcinoma(331;0.0642)		GAAGCAGCATGAGCTTCCCGT	0.507000													90	84					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23872566	23872566	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr14:23872566C>G	ENST00000405093.3	-	10	959	c.889G>C	c.(889-891)Gag>Cag	p.E297Q	MYH6_ENST00000356287.3_Missense_Mutation_p.E297Q	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	297	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		CCCAGCAACTCCGGCTTCTTG	0.602000													132	186					0	0	1	0	0
SYNJ1	8867	broad.mit.edu	37	21	34051036	34051036	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr21:34051036C>T	ENST00000382499.2	-	12	1545	c.1546G>A	c.(1546-1548)Gat>Aat	p.D516N	SYNJ1_ENST00000357345.3_Missense_Mutation_p.D477N|SYNJ1_ENST00000433931.2_Missense_Mutation_p.D516N|SYNJ1_ENST00000382491.3_Missense_Mutation_p.D480N|SYNJ1_ENST00000322229.7_Missense_Mutation_p.D477N	NM_203446.2	NP_982271.2	O43426	SYNJ1_HUMAN	synaptojanin 1	477	Catalytic (Potential).						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|lung(11)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	57						AGCAAAACATCAATGGCCTCT	0.408000													38	106					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	138414422	138414422	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:138414422G>C	ENST00000409968.1	+	23	4340	c.4162G>C	c.(4162-4164)Gat>Cat	p.D1388H	THSD7B_ENST00000413152.2_Missense_Mutation_p.D1360H|THSD7B_ENST00000543459.1_Intron|THSD7B_ENST00000272643.3_Missense_Mutation_p.D1391H					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		AACCTGCATTGATGGAAGAAG	0.458000													40	55					0	0	1	0	0
C19orf53	28974	broad.mit.edu	37	19	13888913	13888913	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:13888913G>A	ENST00000588234.1	+	3	511	c.201G>A	c.(199-201)atG>atA	p.M67I	C19orf53_ENST00000593274.1_Missense_Mutation_p.M24I	NM_014047.2	NP_054766.1	Q9UNZ5	L10K_HUMAN	chromosome 19 open reading frame 53	67										breast(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	6			OV - Ovarian serous cystadenocarcinoma(19;7.7e-24)|Epithelial(5;2.53e-19)			ACGTGGTGATGAAAGCCAGCA	0.592000													47	90					0	0	1	0	0
SFRP2	6423	broad.mit.edu	37	4	154709787	154709787	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr4:154709787C>G	ENST00000274063.4	-	1	485	c.201G>C	c.(199-201)gaG>gaC	p.E67D		NM_003013.2	NP_003004.1	Q96HF1	SFRP2_HUMAN	secreted frizzled-related protein 2	67	FZ.				brain development|cardiac left ventricle morphogenesis|cell-cell signaling|dermatome development|hemopoietic stem cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell growth|negative regulation of cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of transcription, DNA-dependent|outflow tract morphogenesis|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell adhesion mediated by integrin|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of fat cell differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter|regulation of stem cell division|sclerotome development	cytoplasm|extracellular matrix|extracellular space|plasma membrane	fibronectin binding|integrin binding|PDZ domain binding|receptor agonist activity|Wnt receptor activity|Wnt-protein binding			breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(1)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	16	all_hematologic(180;0.093)	Renal(120;0.117)				CCTTCATGGTCTCGTGGCCCA	0.622000													35	74					0	0	1	0	0
COL6A5	256076	broad.mit.edu	37	3	130187926	130187926	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:130187926G>C	ENST00000265379.6	+	38	7572	c.7078G>C	c.(7078-7080)Gat>Cat	p.D2360H	COL6A5_ENST00000432398.2_Missense_Mutation_p.D2360H			A8TX70	CO6A5_HUMAN	collagen, type VI, alpha 5	2360	Nonhelical region.|VWFA 10.				axon guidance|cell adhesion	collagen				endometrium(6)|kidney(4)|large_intestine(8)|lung(19)|pancreas(2)|prostate(3)|stomach(1)|urinary_tract(1)	44						CCTGGAATTTGATTTGGTTAC	0.453000													16	32					0	0	1	0	0
NOTCH1	4851	broad.mit.edu	37	9	139410068	139410068	+	Silent	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr9:139410068G>C	ENST00000277541.6	-	11	1845	c.1770C>G	c.(1768-1770)ctC>ctG	p.L590L		NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	590	EGF-like 15; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CTGGGCGGCAGAGGCAGGTGA	0.687000			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			6	18					0	0	1	0	0
GNE	10020	broad.mit.edu	37	9	36236873	36236873	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr9:36236873G>A	ENST00000396594.3	-	4	929	c.818C>T	c.(817-819)tCa>tTa	p.S273L	GNE_ENST00000447283.2_Missense_Mutation_p.S242L|GNE_ENST00000539815.1_Missense_Mutation_p.S242L|GNE_ENST00000543356.2_Missense_Mutation_p.S237L|GNE_ENST00000377902.5_Missense_Mutation_p.S242L|GNE_ENST00000539208.1_Intron	NM_001128227.2	NP_001121699.1	Q9Y223	GLCNE_HUMAN	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	242					cell adhesion|lipopolysaccharide biosynthetic process|N-acetylneuraminate metabolic process|UDP-N-acetylglucosamine metabolic process		ATP binding|N-acylmannosamine kinase activity|UDP-N-acetylglucosamine 2-epimerase activity			endometrium(8)|kidney(1)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	19			STAD - Stomach adenocarcinoma(86;0.228)			CTTGTTAAATGAGATAAGTGC	0.348000													38	51					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60898905	60898905	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr20:60898905C>T	ENST00000252999.3	-	44	5842	c.5776G>A	c.(5776-5778)Gag>Aag	p.E1926K		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	1926	Laminin EGF-like 18.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACACAGCCCTCGGCGAAGCTG	0.687000													10	11					0	0	1	0	0
LTB4R2	56413	broad.mit.edu	37	14	24780920	24780920	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr14:24780920G>A	ENST00000528054.1	+	1	2760	c.1143G>A	c.(1141-1143)gaG>gaA	p.E381E	LTB4R2_ENST00000533293.1_Silent_p.E350E|LTB4R_ENST00000345363.3_5'UTR|LTB4R2_ENST00000543919.1_Silent_p.E350E			Q9NPC1	LT4R2_HUMAN	leukotriene B4 receptor 2	381					chemotaxis|negative regulation of adenylate cyclase activity	integral to plasma membrane				endometrium(1)|lung(1)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.018)		GTGGGATGGAGAAGGACGGTC	0.647000													34	44					0	0	1	0	0
LRRC37A4P	55073	broad.mit.edu	37	17	43587569	43587569	+	RNA	SNP	G	G	C	rs149697015	by1000genomes	TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr17:43587569G>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							aactccgtctgaaaagaaaag	0.443000													5	88					0	0	1	0	0
CRNKL1	51340	broad.mit.edu	37	20	20018015	20018015	+	Silent	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr20:20018015G>C	ENST00000377340.2	-	14	2362	c.2331C>G	c.(2329-2331)ctC>ctG	p.L777L	CRNKL1_ENST00000377327.4_Silent_p.L765L|CRNKL1_ENST00000521379.1_5'UTR|CRNKL1_ENST00000536226.1_Silent_p.L616L	NM_001278628.1|NM_016652.4	NP_001265557.1|NP_057736.4	Q9BZJ0	CRNL1_HUMAN	crooked neck pre-mRNA splicing factor 1	777					spliceosome assembly	catalytic step 2 spliceosome|cytoplasm|nuclear speck	RNA binding			breast(2)|cervix(2)|endometrium(7)|large_intestine(11)|lung(12)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(6)	45						TCTCTGGCATGAGTTTGTCTA	0.438000													109	203					0	0	1	0	0
DDX51	317781	broad.mit.edu	37	12	132625036	132625036	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr12:132625036G>A	ENST00000397333.3	-	11	1643	c.1605C>T	c.(1603-1605)ttC>ttT	p.F535F		NM_175066.3	NP_778236.2	Q8N8A6	DDX51_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 51	535	Helicase C-terminal.				rRNA processing	nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			endometrium(1)|lung(5)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.241)		OV - Ovarian serous cystadenocarcinoma(86;7.59e-08)|Epithelial(86;3.62e-07)|all cancers(50;2.13e-05)		AGCGCGAGGAGAACTCAGCCA	0.612000													10	74					0	0	1	0	0
CDK17	5128	broad.mit.edu	37	12	96692698	96692698	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr12:96692698C>T	ENST00000261211.3	-	7	1267	c.664G>A	c.(664-666)Gag>Aag	p.E222K	CDK17_ENST00000553042.1_5'UTR|CDK17_ENST00000543119.2_Missense_Mutation_p.E222K|CDK17_ENST00000542666.1_Missense_Mutation_p.E169K	NM_001170464.2|NM_002595.4	NP_001163935.1|NP_002586.2	Q00537	CDK17_HUMAN	cyclin-dependent kinase 17	222	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(6)|lung(11)|ovary(4)|prostate(2)|skin(1)	37						AATCGGATCTCTTTTAATGCC	0.323000													39	58					0	0	1	0	0
MIB1	57534	broad.mit.edu	37	18	19358105	19358105	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr18:19358105C>G	ENST00000261537.6	+	5	942	c.678C>G	c.(676-678)ttC>ttG	p.F226L	MIB1_ENST00000578646.1_3'UTR	NM_020774.2	NP_065825.1	Q86YT6	MIB1_HUMAN	mindbomb E3 ubiquitin protein ligase 1	226					Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(13)|ovary(5)	27			STAD - Stomach adenocarcinoma(5;0.212)			GAGGTTCTTTCTACAGAGATC	0.393000													59	93					0	0	1	0	0
OR51V1	283111	broad.mit.edu	37	11	5221421	5221421	+	Silent	SNP	G	G	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr11:5221421G>T	ENST00000321255.1	-	1	509	c.510C>A	c.(508-510)atC>atA	p.I170I		NM_001004760.2	NP_001004760.2	Q9H2C8	O51V1_HUMAN	olfactory receptor, family 51, subfamily V, member 1	170					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(13)|lung(19)|skin(2)|upper_aerodigestive_tract(2)	39		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.83e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATTTCAGACAGATGATGGGGG	0.398000													46	71					1.06522e-23	1.12329e-23	1	1	0
TTN	7273	broad.mit.edu	37	2	179400910	179400910	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:179400910G>A	ENST00000589042.1	-	357	100788	c.100564C>T	c.(100564-100566)Cat>Tat	p.H33522Y	TTN-AS1_ENST00000591466.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.H24649Y|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.H30954Y|TTN_ENST00000460472.2_Missense_Mutation_p.H24457Y|TTN-AS1_ENST00000588716.1_RNA|TTN-AS1_ENST00000585358.1_RNA|TTN-AS1_ENST00000589842.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000588257.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000589434.1_RNA|TTN-AS1_ENST00000450692.2_RNA|TTN-AS1_ENST00000431259.2_RNA|TTN-AS1_ENST00000592836.1_RNA|TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000585487.1_RNA|TTN-AS1_ENST00000588804.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000591867.1_RNA|TTN-AS1_ENST00000589391.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.H31881Y|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000588244.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.H24582Y|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000592182.1_RNA|TTN-AS1_ENST00000592750.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	31881	Ig-like 147.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGTTTTGGATGACCAGTCACT	0.403000													18	25					0	0	1	0	0
PIK3IP1	113791	broad.mit.edu	37	22	31685334	31685334	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr22:31685334C>G	ENST00000215912.5	-	5	737	c.554G>C	c.(553-555)gGa>gCa	p.G185A	PIK3IP1_ENST00000441972.1_Intron|PIK3IP1_ENST00000402249.3_Missense_Mutation_p.G185A|PIK3IP1_ENST00000487265.2_Missense_Mutation_p.G106A	NM_052880.4	NP_443112.2	Q96FE7	P3IP1_HUMAN	phosphoinositide-3-kinase interacting protein 1	185						integral to membrane				large_intestine(2)|lung(1)|ovary(1)	4						GATGCCAGCTCCGATGGCAAT	0.507000													18	21					0	0	1	0	0
MIR7162	102466227	broad.mit.edu	37	15	62539297	62539297	+	RNA	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr15:62539297C>T	ENST00000570077.1	-	0	292																											CTCTCTCCTCCCTCAACGTGT	0.607000													13	20					0	0	1	0	0
TMPRSS11D	9407	broad.mit.edu	37	4	68691546	68691546	+	Silent	SNP	A	A	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr4:68691546A>G	ENST00000283916.6	-	9	1097	c.999T>C	c.(997-999)agT>agC	p.S333S	TMPRSS11D_ENST00000545541.1_Silent_p.S216S|UBA6-AS1_ENST00000500538.2_RNA	NM_004262.2	NP_004253.1	O60235	TM11D_HUMAN	transmembrane protease, serine 11D	333	Peptidase S1.				proteolysis|respiratory gaseous exchange	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23						ATACATCATTACTTATTATTC	0.413000													39	55					0	0	1	0	0
POM121L12	285877	broad.mit.edu	37	7	53103863	53103863	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr7:53103863C>T	ENST00000408890.4	+	1	515	c.499C>T	c.(499-501)Cag>Tag	p.Q167*		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	167										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						ccccgccgcccAGGAGCTCCT	0.721000													19	17					0	0	1	0	0
PCDHGA11	56105	broad.mit.edu	37	5	140801036	140801036	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr5:140801036G>A	ENST00000398587.2	+	1	275	c.242G>A	c.(241-243)cGa>cAa	p.R81Q	PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA11_ENST00000518882.1_Missense_Mutation_p.R81Q|PCDHGB7_ENST00000398594.2_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA8_ENST00000398604.2_Intron	NM_018914.2|NM_032092.1	NP_061737.1|NP_114481.1														breast(3)|endometrium(8)|kidney(3)|large_intestine(9)|lung(22)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGAATCCGCGAAGCGGCAGC	0.577000													62	105					0	0	1	0	0
ASPSCR1	79058	broad.mit.edu	37	17	79943433	79943433	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr17:79943433C>T	ENST00000306729.7	+	4	421	c.324C>T	c.(322-324)ttC>ttT	p.F108F	ASPSCR1_ENST00000306739.4_Silent_p.F108F|ASPSCR1_ENST00000581647.1_Silent_p.F108F|ASPSCR1_ENST00000580534.1_Silent_p.F31F	NM_001251888.1	NP_001238817.1	Q9BZE9	ASPC1_HUMAN	alveolar soft part sarcoma chromosome region, candidate 1	108							protein binding		ASPSCR1/TFE3(167)	breast(2)|large_intestine(2)	4	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			AGGACTCTTTCTGTTCAGGCC	0.527000			T	TFE3	alveolar soft part sarcoma								43	61					0	0	1	0	0
DOCK6	57572	broad.mit.edu	37	19	11362826	11362826	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:11362826G>A	ENST00000294618.7	-	5	487	c.476C>T	c.(475-477)tCt>tTt	p.S159F		NM_020812.3	NP_065863.2	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	159					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|endometrium(11)|large_intestine(8)|liver(2)|lung(9)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	39						CTCGTCTCCAGAAGCATCCTG	0.622000													7	8					0	0	1	0	0
ZNF345	25850	broad.mit.edu	37	19	37368114	37368114	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:37368114G>C	ENST00000529555.1	+	2	1170	c.382G>C	c.(382-384)Ggt>Cgt	p.G128R	ZNF345_ENST00000432005.2_Intron|ZNF345_ENST00000589046.1_Missense_Mutation_p.G128R|ZNF345_ENST00000526123.1_Intron|ZNF345_ENST00000420450.1_Missense_Mutation_p.G128R			Q14585	ZN345_HUMAN	zinc finger protein 345	128					negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(5)|ovary(2)|prostate(1)	24	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GAAGGCCTTTGGTAGTGGCTC	0.438000													54	106					0	0	1	0	0
BAHD1	22893	broad.mit.edu	37	15	40756200	40756200	+	Silent	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr15:40756200C>G	ENST00000561234.1	+	4	2212	c.1953C>G	c.(1951-1953)ctC>ctG	p.L651L	BAHD1_ENST00000416165.1_Silent_p.L652L|BAHD1_ENST00000560846.1_Silent_p.L652L			Q8TBE0	BAHD1_HUMAN	bromo adjacent homology domain containing 1	652	BAH.				heterochromatin formation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin silencing complex|chromosome	chromatin binding|DNA binding|protein binding			NS(1)|endometrium(6)|kidney(3)|large_intestine(3)|lung(10)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	28		all_cancers(109;8.28e-19)|all_epithelial(112;2.64e-15)|Lung NSC(122;5.14e-11)|all_lung(180;1.27e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.46e-06)|BRCA - Breast invasive adenocarcinoma(123;0.08)		TCTCTGCCCTCTGGGAGAACC	0.607000													30	32					0	0	1	0	0
ARMCX1	51309	broad.mit.edu	37	X	100808511	100808511	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chrX:100808511G>A	ENST00000372829.3	+	4	969	c.598G>A	c.(598-600)Gat>Aat	p.D200N		NM_016608.1	NP_057692.1	Q9P291	ARMX1_HUMAN	armadillo repeat containing, X-linked 1	200						integral to membrane	binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(2)|ovary(3)|pancreas(1)|urinary_tract(1)	19						TAAAATTGATGATATTCTGAG	0.468000													131	46					0	0	1	0	0
ZNF423	23090	broad.mit.edu	37	16	49669905	49669905	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr16:49669905G>C	ENST00000561648.1	-	4	3211	c.3158C>G	c.(3157-3159)tCc>tGc	p.S1053C	ZNF423_ENST00000262383.2_Missense_Mutation_p.S1053C|ZNF423_ENST00000562520.1_Missense_Mutation_p.S993C|ZNF423_ENST00000535559.1_Missense_Mutation_p.S936C|ZNF423_ENST00000562871.1_Missense_Mutation_p.S993C|ZNF423_ENST00000567169.1_Missense_Mutation_p.S936C|ZNF423_ENST00000563137.2_Missense_Mutation_p.S993C	NM_001271620.1	NP_001258549.1	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	1053					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				ATTGGGGGAGGACGCCGCTGA	0.602000													6	43					0	0	1	0	0
AP5Z1	9907	broad.mit.edu	37	7	4823978	4823978	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr7:4823978G>A	ENST00000348624.4	+	6	860	c.766G>A	c.(766-768)Gag>Aag	p.E256K	AP5Z1_ENST00000401897.1_Missense_Mutation_p.E256K	NM_014855.2	NP_055670.1	O43299	K0415_HUMAN	adaptor-related protein complex 5, zeta 1 subunit	256					cell death|double-strand break repair via homologous recombination	cytoplasm|nucleus	protein binding										CAGCGGCCCCGAGGGCCCGGG	0.692000													10	18					0	0	1	0	0
ARID2	196528	broad.mit.edu	37	12	46231142	46231142	+	Silent	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr12:46231142G>C	ENST00000334344.6	+	9	1234	c.1062G>C	c.(1060-1062)ctG>ctC	p.L354L	ARID2_ENST00000479608.1_3'UTR|ARID2_ENST00000422737.1_Silent_p.L205L	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	354					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		CTACTCATCTGATGTTTCATA	0.318000			"""N, S, F"""		hepatocellular carcinoma								70	144					0	0	1	0	0
IKZF2	22807	broad.mit.edu	37	2	213914550	213914550	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:213914550T>C	ENST00000457361.1	-	5	629	c.461A>G	c.(460-462)aAc>aGc	p.N154S	IKZF2_ENST00000342002.2_Missense_Mutation_p.N160S|IKZF2_ENST00000434687.1_Missense_Mutation_p.N154S|IKZF2_ENST00000413091.3_Missense_Mutation_p.N154S|IKZF2_ENST00000374327.4_Intron|IKZF2_ENST00000421754.2_Missense_Mutation_p.N128S|IKZF2_ENST00000451136.2_Missense_Mutation_p.N128S|IKZF2_ENST00000374319.4_Missense_Mutation_p.N128S	NM_016260.2	NP_057344.2	Q9UKS7	IKZF2_HUMAN	IKAROS family zinc finger 2 (Helios)	154					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(7)|lung(7)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		Esophageal squamous(248;0.0559)|Renal(323;0.218)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;2.97e-07)|all cancers(144;1.53e-05)|LUSC - Lung squamous cell carcinoma(224;0.00599)|Lung(261;0.00792)		TCTCAGAAGGTTGCCCTTCTG	0.488000													23	18					0	0	1	0	0
ENAM	10117	broad.mit.edu	37	4	71508608	71508608	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr4:71508608G>T	ENST00000396073.3	+	9	1746	c.1465G>T	c.(1465-1467)Gat>Tat	p.D489Y	ENAM_ENST00000472903.1_Intron	NM_031889.2	NP_114095.2	Q9NRM1	ENAM_HUMAN	enamelin	489					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			haematopoietic_and_lymphoid_tissue(1)|ovary(3)|upper_aerodigestive_tract(2)	6			Lung(101;0.235)			TAATTCTGTTGATCAACATGA	0.388000													27	59					1.38267e-23	1.45578e-23	1	1	0
MYO1C	4641	broad.mit.edu	37	17	1381931	1381931	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr17:1381931G>A	ENST00000359786.5	-	10	1515	c.1191C>T	c.(1189-1191)atC>atT	p.I397I	MYO1C_ENST00000545534.2_Silent_p.I373I|MYO1C_ENST00000361007.2_Silent_p.I362I|MYO1C_ENST00000438665.2_Silent_p.I378I|MYO1C_ENST00000575158.1_Silent_p.I362I	NM_001080779.1	NP_001074248.1	O00159	MYO1C_HUMAN	myosin IC	397	Myosin head-like.				mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|liver(2)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	17				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		GCGACCTGTTGATCTTCCCGA	0.677000													30	58					0	0	1	0	0
WDR33	55339	broad.mit.edu	37	2	128477643	128477643	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:128477643G>T	ENST00000322313.4	-	16	2114	c.1956C>A	c.(1954-1956)ttC>ttA	p.F652L		NM_018383.4	NP_060853.3	Q9C0J8	WDR33_HUMAN	WD repeat domain 33	652	Collagen-like.				postreplication repair|spermatogenesis	collagen|nucleus	protein binding			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		GTGGTCCCATGAATCCTTGTG	0.652000													31	60					2.61193e-14	2.68735e-14	1	1	0
RB1	5925	broad.mit.edu	37	13	48881435	48881435	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr13:48881435G>T	ENST00000267163.4	+	2	295	c.157G>T	c.(157-159)Gaa>Taa	p.E53*		NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1	53					androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(3)|p.E53K(1)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TGAAGAAACAGAAGAACCTGA	0.328000		6	"""D, Mis, N, F, S"""		"""retinoblastoma, sarcoma, breast, small cell lung"""	"""retinoblastoma, sarcoma, breast, small cell lung"""			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			36	104					1.06647e-15	1.10567e-15	1	1	0
NYNRIN	57523	broad.mit.edu	37	14	24878243	24878243	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr14:24878243G>A	ENST00000382554.3	+	4	1561	c.1243G>A	c.(1243-1245)Gag>Aag	p.E415K		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	415					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						CTTAAATCTGGAGTGGAAGCA	0.587000													8	30					0	0	1	0	0
FAM71A	149647	broad.mit.edu	37	1	212798273	212798273	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:212798273G>A	ENST00000294829.3	+	1	485	c.54G>A	c.(52-54)atG>atA	p.M18I	RP11-338C15.5_ENST00000427949.1_RNA	NM_153606.3	NP_705834.2	Q8IYT1	FA71A_HUMAN	family with sequence similarity 71, member A	18										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(7)|liver(1)|lung(12)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(81;0.00631)|all cancers(67;0.00981)|GBM - Glioblastoma multiforme(131;0.0715)|Epithelial(68;0.094)		GCTCCAGCATGAGCATGTTCA	0.502000													27	29					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228476442	228476442	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:228476442G>C	ENST00000570156.2	+	43	11553	c.11479G>C	c.(11479-11481)Gag>Cag	p.E3827Q	OBSCN_ENST00000422127.1_Missense_Mutation_p.E3398Q|OBSCN_ENST00000359599.6_Missense_Mutation_p.E2245Q|OBSCN_ENST00000366707.4_Missense_Mutation_p.E517Q|OBSCN_ENST00000366709.4_Missense_Mutation_p.E517Q|OBSCN_ENST00000284548.11_Missense_Mutation_p.E3398Q	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	2864	Ig-like 39.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GAAGGGGCGTGAGAGCCTCAG	0.627000													22	99					0	0	1	0	0
RBL2	5934	broad.mit.edu	37	16	53496559	53496559	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr16:53496559G>C	ENST00000262133.6	+	11	1689	c.1552G>C	c.(1552-1554)Gat>Cat	p.D518H	RBL2_ENST00000544545.1_Missense_Mutation_p.D302H|RBL2_ENST00000379935.4_3'UTR	NM_005611.3	NP_005602.3	Q08999	RBL2_HUMAN	retinoblastoma-like 2 (p130)	518	Domain A.|Pocket; binds E1A.				cell cycle|chromatin modification|regulation of cell cycle|regulation of lipid kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(17)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45						AGGAGACATGGATTTATCTGT	0.328000													38	15					0	0	1	0	0
ABHD17C	58489	broad.mit.edu	37	15	81046550	81046550	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr15:81046550G>A	ENST00000258884.4	+	3	956	c.829G>A	c.(829-831)Gag>Aag	p.E277K	ABHD17C_ENST00000558464.1_Missense_Mutation_p.E243K|ABHD17C_ENST00000560609.1_Missense_Mutation_p.E42K|ABHD17C_ENST00000559506.1_3'UTR	NM_021214.1	NP_067037.1			abhydrolase domain containing 17C																		TACAGAGGATGAGGTCATCGA	0.517000													24	32					0	0	1	0	0
LYG2	254773	broad.mit.edu	37	2	99858936	99858936	+	Nonsense_Mutation	SNP	G	G	C	rs140539656		TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:99858936G>C	ENST00000333017.2	-	6	642	c.530C>G	c.(529-531)tCa>tGa	p.S177*	LYG2_ENST00000423800.1_3'UTR|LYG2_ENST00000409238.1_Nonsense_Mutation_p.S177*	NM_175735.3	NP_783862.2	Q86SG7	LYG2_HUMAN	lysozyme G-like 2	177				GLSAFKSG -> RLYSEYFY (in Ref. 4).	cell wall macromolecule catabolic process|peptidoglycan catabolic process	extracellular region	lysozyme activity			large_intestine(3)|lung(4)|ovary(1)|prostate(2)|skin(1)|stomach(1)	12						CTTAAAAGCTGAGAGACCACC	0.388000													83	163					0	0	1	0	0
PMS2CL	441194	broad.mit.edu	37	7	6777425	6777425	+	RNA	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr7:6777425C>G	ENST00000486256.1	+	0	1552					NR_002217.1																						CTGAACTTTTCTGAGTTCTTT	0.393000													48	74					0	0	1	0	0
ZFC3H1	196441	broad.mit.edu	37	12	72030746	72030746	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr12:72030746C>T	ENST00000378743.3	-	8	2177	c.1819G>A	c.(1819-1821)Gaa>Aaa	p.E607K		NM_144982.4	NP_659419.3	O60293	ZC3H1_HUMAN	zinc finger, C3H1-type containing	607	Pro-rich.				RNA processing	intracellular	metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(31)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						TCTGGATCTTCAGGTGGGAGA	0.453000													112	93					0	0	1	0	0
CD209	30835	broad.mit.edu	37	19	7810602	7810602	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:7810602G>A	ENST00000315599.7	-	4	572	c.550C>T	c.(550-552)Cca>Tca	p.P184S	CD209_ENST00000394173.4_Intron|CD209_ENST00000601951.1_Missense_Mutation_p.P160S|CD209_ENST00000394161.5_Intron|CD209_ENST00000354397.6_Missense_Mutation_p.P184S|CD209_ENST00000593660.1_Missense_Mutation_p.P160S|CD209_ENST00000204801.8_Missense_Mutation_p.P140S|CD209_ENST00000315591.8_Missense_Mutation_p.P160S|CD209_ENST00000593821.1_Intron|CD209_ENST00000601256.1_Missense_Mutation_p.P160S|CD209_ENST00000602261.1_Intron|CD209_ENST00000301357.8_Intron	NM_001144895.1|NM_001144897.1|NM_021155.3	NP_001138367.1|NP_001138369.1|NP_066978.1	Q9NNX6	CD209_HUMAN	CD209 molecule	184	7 X approximate tandem repeats.				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding			endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						GATTTCTCTGGAAGCTCACCC	0.547000													96	207					0	0	1	0	0
KMT2E	55904	broad.mit.edu	37	7	104750987	104750987	+	Nonsense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr7:104750987C>G	ENST00000311117.3	+	25	4453	c.3908C>G	c.(3907-3909)tCa>tGa	p.S1303*	KMT2E_ENST00000334914.7_Nonsense_Mutation_p.S358*|KMT2E_ENST00000334877.4_Intron|KMT2E_ENST00000257745.4_Nonsense_Mutation_p.S1303*	NM_182931.2	NP_891847.1			lysine (K)-specific methyltransferase 2E																		TCATCTCATTCAAATCACATA	0.438000													62	109					0	0	1	0	0
LGI3	203190	broad.mit.edu	37	8	22006323	22006323	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr8:22006323C>G	ENST00000306317.2	-	8	1286	c.997G>C	c.(997-999)Gaa>Caa	p.E333Q	LGI3_ENST00000424267.2_Missense_Mutation_p.E309Q	NM_139278.2	NP_644807.1	Q8N145	LGI3_HUMAN	leucine-rich repeat LGI family, member 3	333					exocytosis	cell junction|extracellular region|synaptic vesicle|synaptosome				endometrium(4)|large_intestine(3)|lung(7)|ovary(1)|upper_aerodigestive_tract(2)	17				Colorectal(74;0.00189)|COAD - Colon adenocarcinoma(73;0.0612)|READ - Rectum adenocarcinoma(644;0.0999)		CGGAAGGCTTCTAGGTCGTTA	0.597000													21	11					0	0	1	0	0
SLC4A5	57835	broad.mit.edu	37	2	74474302	74474302	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:74474302G>A	ENST00000394019.2	-	19	2317	c.1920C>T	c.(1918-1920)ttC>ttT	p.F640F	SLC4A5_ENST00000357822.5_Silent_p.F640F|SLC4A5_ENST00000359484.4_Silent_p.F576F|SLC4A5_ENST00000377634.4_Silent_p.F640F|SLC4A5_ENST00000346834.4_Silent_p.F640F|SLC4A5_ENST00000358683.4_Silent_p.F576F|SLC4A5_ENST00000483195.1_5'UTR|SLC4A5_ENST00000377632.1_Silent_p.F640F|RP11-287D1.3_ENST00000451608.2_3'UTR|SLC4A5_ENST00000423644.1_Silent_p.F640F	NM_133478.2	NP_597812.1	Q9BY07	S4A5_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 5	640						apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						TAAGGGTGGAGAAGCCCTCCT	0.473000													93	163					0	0	1	0	0
NELFE	7936	broad.mit.edu	37	6	31922575	31922575	+	Missense_Mutation	SNP	C	C	G	rs55821537		TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr6:31922575C>G	ENST00000375429.3	-	7	725	c.499G>C	c.(499-501)Gac>Cac	p.D167H	NELFE_ENST00000444811.2_Missense_Mutation_p.D137H|NELFE_ENST00000375425.5_Missense_Mutation_p.D174H	NM_002904.5	NP_002895.3			negative elongation factor complex member E																		TAGCCCCAGTCAAAGCTTCGA	0.622000													68	120					0	0	1	0	0
SAAL1	113174	broad.mit.edu	37	11	18124839	18124839	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr11:18124839C>T	ENST00000524803.1	-	2	239	c.190G>A	c.(190-192)Gag>Aag	p.E64K	SAAL1_ENST00000529318.1_Missense_Mutation_p.E64K|SAAL1_ENST00000533851.1_5'UTR|SAAL1_ENST00000300013.4_Missense_Mutation_p.E64K			Q96ER3	SAAL1_HUMAN	serum amyloid A-like 1	64					acute-phase response	extracellular region	binding			breast(2)|large_intestine(5)|lung(8)	15						TCATCAAGCTCCGTCAGCTGC	0.398000													57	117					0	0	1	0	0
SMCR8	140775	broad.mit.edu	37	17	18220896	18220896	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr17:18220896C>T	ENST00000406438.3	+	1	2273	c.1793C>T	c.(1792-1794)cCc>cTc	p.P598L		NM_144775.2	NP_658988.2	Q8TEV9	SMCR8_HUMAN	Smith-Magenis syndrome chromosome region, candidate 8	598										breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	21						TTGGTGCTGCCCTCCACTCCA	0.572000													27	48					0	0	1	0	0
FANCM	57697	broad.mit.edu	37	14	45623214	45623214	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr14:45623214C>T	ENST00000267430.5	+	6	1227	c.1142C>T	c.(1141-1143)tCa>tTa	p.S381L	FANCM_ENST00000556036.1_Missense_Mutation_p.S381L|FANCM_ENST00000542564.2_Missense_Mutation_p.S355L	NM_020937.2	NP_065988.1	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	381					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(31)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	85						GGAATGAGATCATTATATTTC	0.284000								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				74	64					0	0	1	0	0
ANKRD24	170961	broad.mit.edu	37	19	4207244	4207244	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:4207244G>A	ENST00000600132.1	+	8	748	c.472G>A	c.(472-474)Ggt>Agt	p.G158S	ANKRD24_ENST00000318934.4_Missense_Mutation_p.G158S|ANKRD24_ENST00000262970.5_Missense_Mutation_p.G248S	NM_133475.1	NP_597732.1	Q8TF21	ANR24_HUMAN	ankyrin repeat domain 24	158										endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)	21				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0233)|STAD - Stomach adenocarcinoma(1328;0.181)		TGCAGCGGCTGGTGGCTGTCT	0.542000											OREG0025162	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	26					0	0	1	0	0
DEPDC5	9681	broad.mit.edu	37	22	32156646	32156646	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr22:32156646C>G	ENST00000400246.1	+	4	293	c.151C>G	c.(151-153)Ctg>Gtg	p.L51V	DEPDC5_ENST00000266091.3_Missense_Mutation_p.L51V|DEPDC5_ENST00000400248.2_Missense_Mutation_p.L51V|DEPDC5_ENST00000536766.1_Missense_Mutation_p.L51V|DEPDC5_ENST00000400242.3_Missense_Mutation_p.L51V|DEPDC5_ENST00000382112.3_Missense_Mutation_p.L51V|DEPDC5_ENST00000535622.1_Missense_Mutation_p.L51V|DEPDC5_ENST00000400249.2_Missense_Mutation_p.L51V|DEPDC5_ENST00000382105.2_Missense_Mutation_p.L51V|DEPDC5_ENST00000382111.2_Missense_Mutation_p.L51V			O75140	DEPD5_HUMAN	DEP domain containing 5	51					intracellular signal transduction					breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(24)|ovary(5)|pancreas(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						TTTCAGCCCTCTGCTTTTGCA	0.408000													34	41					0	0	1	0	0
DOCK6	57572	broad.mit.edu	37	19	11313334	11313334	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:11313334C>T	ENST00000294618.7	-	42	5298	c.5287G>A	c.(5287-5289)Gac>Aac	p.D1763N	DOCK6_ENST00000586702.1_5'UTR|DOCK6_ENST00000319867.7_Missense_Mutation_p.D1102N	NM_020812.3	NP_065863.2	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	1763	DHR-2.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|endometrium(11)|large_intestine(8)|liver(2)|lung(9)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	39						TCATCCAGGTCACCGAAGTGG	0.617000													98	141					0	0	1	0	0
RAB10	10890	broad.mit.edu	37	2	26332716	26332716	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:26332716G>A	ENST00000264710.4	+	3	767	c.268G>A	c.(268-270)Gac>Aac	p.D90N	RAB10_ENST00000462003.1_3'UTR	NM_016131.4	NP_057215.3	P61026	RAB10_HUMAN	RAB10, member RAS oncogene family	90					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|protein binding			lung(2)|ovary(1)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCTAGTATATGACATCACCAA	0.403000													40	72					0	0	1	0	0
ECT2L	345930	broad.mit.edu	37	6	139202233	139202233	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr6:139202233C>T	ENST00000423192.1	+	14	1966	c.1805C>T	c.(1804-1806)tCa>tTa	p.S602L	ECT2L_ENST00000367682.2_Missense_Mutation_p.S602L|ECT2L_ENST00000541398.1_Missense_Mutation_p.S533L			Q008S8	ECT2L_HUMAN	epithelial cell transforming sequence 2 oncogene-like	602	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(7)|lung(12)|skin(1)|upper_aerodigestive_tract(1)	30						GCATTGTCATCAAACAGAGCG	0.383000			"""N, Splice, Mis"""		ETP ALL								31	52					0	0	1	0	0
SMG8	55181	broad.mit.edu	37	17	57287728	57287728	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr17:57287728G>A	ENST00000543872.2	+	2	580	c.316G>A	c.(316-318)Gag>Aag	p.E106K	SMG8_ENST00000300917.5_Missense_Mutation_p.E106K|CTD-2510F5.6_ENST00000577660.1_Intron|SMG8_ENST00000578922.1_Missense_Mutation_p.E106K|SMG8_ENST00000580498.1_Intron			Q8ND04	SMG8_HUMAN	SMG8 nonsense mediated mRNA decay factor	106					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of protein kinase activity		protein binding			NS(1)|breast(5)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(1)	33						CGGTGGAGCCGAGGACCCTGG	0.637000													14	26					0	0	1	0	0
HARS	3035	broad.mit.edu	37	5	140056626	140056626	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr5:140056626C>G	ENST00000504366.1	-	8	2511	c.692G>C	c.(691-693)gGa>gCa	p.G231A	HARS_ENST00000431330.2_Missense_Mutation_p.G186A|HARS_ENST00000448240.1_Missense_Mutation_p.G105A|HARS_ENST00000307633.3_Missense_Mutation_p.G240A|HARS_ENST00000415192.2_Missense_Mutation_p.G226A|HARS_ENST00000457527.2_Missense_Mutation_p.G280A|HARS_ENST00000438307.2_Missense_Mutation_p.G260A|HARS_ENST00000504156.1_Missense_Mutation_p.G300A			P12081	SYHC_HUMAN	histidyl-tRNA synthetase	300					histidyl-tRNA aminoacylation	cytosol	ATP binding|histidine-tRNA ligase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	19			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		L-Histidine(DB00117)	CTTCAGGTCTCCCAGGCCCTC	0.542000													147	243					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13839557	13839557	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr5:13839557C>T	ENST00000265104.4	-	35	5894	c.5790G>A	c.(5788-5790)aaG>aaA	p.K1930K		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1930	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GAATCATCATCTTGTCAGAAT	0.388000									Kartagener syndrome				22	46					0	0	1	0	0
AXDND1	126859	broad.mit.edu	37	1	179348604	179348604	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:179348604G>C	ENST00000367618.3	+	6	955	c.568G>C	c.(568-570)Gag>Cag	p.E190Q	AXDND1_ENST00000457238.2_Missense_Mutation_p.E190Q|AXDND1_ENST00000461179.2_3'UTR	NM_144696.4	NP_653297.3	Q5T1B0	AXDN1_HUMAN	axonemal dynein light chain domain containing 1	190										NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(27)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	59						TTCAGGTTTGGAGTGTTATGA	0.413000													15	57					0	0	1	0	0
TIMP4	7079	broad.mit.edu	37	3	12198407	12198407	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:12198407C>T	ENST00000287814.4	-	3	775	c.265G>A	c.(265-267)Gat>Aat	p.D89N	SYN2_ENST00000432424.2_RNA	NM_003256.3	NP_003247.1	Q99727	TIMP4_HUMAN	TIMP metallopeptidase inhibitor 4	89	NTR.						metal ion binding|metalloendopeptidase inhibitor activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	11						TACTGAACATCCTTGACTTTC	0.388000													45	67					0	0	1	0	0
THBS4	7060	broad.mit.edu	37	5	79355285	79355285	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr5:79355285G>A	ENST00000350881.2	+	6	945	c.755G>A	c.(754-756)cGa>cAa	p.R252Q	THBS4_ENST00000511733.1_Missense_Mutation_p.R161Q|CTD-2201I18.1_ENST00000503007.1_RNA	NM_003248.4	NP_003239.2	P35443	TSP4_HUMAN	thrombospondin 4	252					endothelial cell-cell adhesion|myoblast migration|negative regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation	basement membrane|extracellular space	calcium ion binding|heparin binding|integrin binding|structural molecule activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|stomach(3)	34		Lung NSC(167;0.00328)|all_lung(232;0.00355)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-45)|Epithelial(54;1.77e-39)|all cancers(79;3.2e-34)		TCATTTTTGCGAAACACCATA	0.448000													65	118					0	0	1	0	0
SRPK1	6732	broad.mit.edu	37	6	35856666	35856666	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr6:35856666G>A	ENST00000373825.2	-	4	513	c.228C>T	c.(226-228)ttC>ttT	p.F76F	SRPK1_ENST00000423325.2_Silent_p.F60F|SRPK1_ENST00000373821.2_5'UTR|SRPK1_ENST00000373822.1_5'UTR			Q96SB4	SRPK1_HUMAN	SRSF protein kinase 1	76					cell differentiation|chromosome segregation|interspecies interaction between organisms|intracellular protein kinase cascade|mRNA processing|negative regulation of viral genome replication|positive regulation of viral genome replication|regulation of mRNA processing|RNA splicing	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			endometrium(2)|large_intestine(10)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	21						ATCTCCCATTGAATAGATCTC	0.378000													53	82					0	0	1	0	0
ZNF521	25925	broad.mit.edu	37	18	22805860	22805860	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr18:22805860G>A	ENST00000361524.3	-	4	2170	c.2022C>T	c.(2020-2022)ccC>ccT	p.P674P	ZNF521_ENST00000584787.1_Silent_p.P454P|ZNF521_ENST00000538137.2_Silent_p.P674P	NM_015461.2	NP_056276.1	Q96K83	ZN521_HUMAN	zinc finger protein 521	674					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(21)|lung(97)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	149	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					ATTCTTGGTTGGGGAATTCCT	0.423000			T	PAX5	ALL								92	163					0	0	1	0	0
CEP170B	283638	broad.mit.edu	37	14	105352817	105352817	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr14:105352817C>T	ENST00000453495.1	+	12	2472	c.2244C>T	c.(2242-2244)ctC>ctT	p.L748L	CEP170B_ENST00000418279.1_Silent_p.L677L|CEP170B_ENST00000556508.1_Silent_p.L677L|CEP170B_ENST00000414716.3_Silent_p.L747L					centrosomal protein 170B																		CTGACAGCCTCAGCGATGCCA	0.711000													3	10					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	144994629	144994629	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr8:144994629C>T	ENST00000322810.4	-	32	9940	c.9771G>A	c.(9769-9771)ctG>ctA	p.L3257L	PLEC_ENST00000354958.2_Silent_p.L3098L|PLEC_ENST00000398774.2_Silent_p.L3088L|PLEC_ENST00000357649.2_Silent_p.L3124L|PLEC_ENST00000356346.3_Silent_p.L3106L|PLEC_ENST00000354589.3_Silent_p.L3120L|PLEC_ENST00000436759.2_Silent_p.L3147L|PLEC_ENST00000527096.1_Silent_p.L3143L|PLEC_ENST00000345136.3_Silent_p.L3120L	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	3257	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						GGCCCTTCTTCAGGGCCTGGA	0.662000													8	27					0	0	1	0	0
TPP2	7174	broad.mit.edu	37	13	103289587	103289587	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr13:103289587G>A	ENST00000376052.3	+	14	1850	c.1834G>A	c.(1834-1836)Gag>Aag	p.E612K	TPP2_ENST00000376065.4_Missense_Mutation_p.E612K			P29144	TPP2_HUMAN	tripeptidyl peptidase II	612					proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(12)|lung(21)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	52	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					GCATTATACAGAGGTATTGAT	0.338000													32	91					0	0	1	0	0
MRGPRX1	259249	broad.mit.edu	37	11	18955396	18955396	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr11:18955396G>A	ENST00000302797.3	-	1	1160	c.936C>T	c.(934-936)atC>atT	p.I312I		NM_147199.3	NP_671732.3	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	312				EEI -> QET (in Ref. 2; AAL86880).	acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|pancreas(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						ACAGCTCCAGGATTTCCTCAG	0.562000													51	72					0	0	1	0	0
TRPC3	7222	broad.mit.edu	37	4	122800972	122800972	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr4:122800972C>G	ENST00000264811.5	-	11	2884	c.2466G>C	c.(2464-2466)aaG>aaC	p.K822N	TRPC3_ENST00000513531.1_Missense_Mutation_p.K767N|TRPC3_ENST00000379645.3_Missense_Mutation_p.K895N	NM_003305.2	NP_003296.1	Q13507	TRPC3_HUMAN	transient receptor potential cation channel, subfamily C, member 3	810					axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(12)|lung(13)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						TTGCTTGGCTCTTGTCTTCCA	0.363000													25	66					0	0	1	0	0
TGM5	9333	broad.mit.edu	37	15	43548885	43548885	+	Splice_Site	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr15:43548885C>G	ENST00000220420.5	-	4	444		c.e4-1		TGM5_ENST00000349114.4_Splice_Site	NM_201631.3	NP_963925.2	O43548	TGM5_HUMAN	transglutaminase 5						epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(11)|lung(15)|skin(6)|urinary_tract(1)	44		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	ACAGCATCCTCTAGGAACCAG	0.527000													42	131					0	0	1	0	0
PSD3	23362	broad.mit.edu	37	8	18729698	18729698	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr8:18729698G>C	ENST00000440756.2	-	3	778	c.676C>G	c.(676-678)Cag>Gag	p.Q226E	PSD3_ENST00000327040.8_Missense_Mutation_p.Q226E|PSD3_ENST00000523619.1_Missense_Mutation_p.Q161E			Q9NYI0	PSD3_HUMAN	pleckstrin and Sec7 domain containing 3	226					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		ATCTCTGCCTGAGTGTCTCCA	0.473000													65	50					0	0	1	0	0
MCMBP	79892	broad.mit.edu	37	10	121595165	121595165	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr10:121595165C>G	ENST00000360003.3	-	14	1769	c.1600G>C	c.(1600-1602)Gag>Cag	p.E534Q	MCMBP_ENST00000369077.3_Missense_Mutation_p.E532Q|MCMBP_ENST00000466047.1_5'UTR	NM_001256378.1|NM_001256379.1|NM_024834.3	NP_001243307.1|NP_001243308.1|NP_079110.1	Q9BTE3	MCMBP_HUMAN	minichromosome maintenance complex binding protein	534					cell division|DNA-dependent DNA replication|mitosis|S phase of mitotic cell cycle|sister chromatid cohesion	nucleus	chromatin binding			breast(1)|endometrium(3)|large_intestine(4)|lung(9)|ovary(2)|skin(2)	21						TTCATGTACTCCTCCATGTTT	0.423000													52	27					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215990453	215990453	+	Silent	SNP	T	T	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:215990453T>C	ENST00000366943.2	-	48	9842	c.9456A>G	c.(9454-9456)ccA>ccG	p.P3152P	USH2A_ENST00000307340.3_Silent_p.P3152P			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	3152	Fibronectin type-III 18.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TTTTAGCGCATGGATACCATG	0.423000										HNSCC(13;0.011)			6	154					0	0	1	0	0
RPS6KA6	27330	broad.mit.edu	37	X	83372137	83372137	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chrX:83372137G>C	ENST00000262752.2	-	11	887	c.880C>G	c.(880-882)Caa>Gaa	p.Q294E	RPS6KA6_ENST00000543399.1_Missense_Mutation_p.Q294E	NM_014496.4	NP_055311.1	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 6	294	Protein kinase 1.				axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(26)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	46						CTAAGAAATTGAGGCATTCCA	0.303000													25	12					0	0	1	0	0
COBL	23242	broad.mit.edu	37	7	51098524	51098524	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr7:51098524C>T	ENST00000395542.2	-	11	1919	c.1735G>A	c.(1735-1737)Gat>Aat	p.D579N	COBL_ENST00000265136.7_Missense_Mutation_p.D497N			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	497										NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					AGGTCTTCATCAAGTTCTGCA	0.433000													58	135					0	0	1	0	0
AGXT2	64902	broad.mit.edu	37	5	35003955	35003955	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr5:35003955C>T	ENST00000231420.6	-	13	1550	c.1350G>A	c.(1348-1350)cgG>cgA	p.R450R		NM_031900.3	NP_114106.1	Q9BYV1	AGT2_HUMAN	alanine--glyoxylate aminotransferase 2	450					glyoxylate metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	mitochondrial matrix	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity|alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(18)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	41	all_lung(31;4.52e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)	GBM - Glioblastoma multiforme(108;0.181)	Glycine(DB00145)|L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)	GGGGAAGAGGCCGACAGCTTA	0.393000											OREG0016558	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	55	82					0	0	1	0	0
ARL15	54622	broad.mit.edu	37	5	53409135	53409135	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr5:53409135C>G	ENST00000504924.1	-	4	452	c.359G>C	c.(358-360)aGa>aCa	p.R120T	ARL15_ENST00000507646.2_Missense_Mutation_p.R120T|ARL15_ENST00000510591.2_5'UTR|ARL15_ENST00000502271.1_5'UTR	NM_019087.2	NP_061960.1	Q9NXU5	ARL15_HUMAN	ADP-ribosylation factor-like 15	120							GTP binding			endometrium(1)|large_intestine(2)|lung(2)|ovary(1)	6		Lung NSC(810;0.000779)				CAGCTCATTTCTAGCAGCTTC	0.438000													30	55					0	0	1	0	0
PALLD	23022	broad.mit.edu	37	4	169630220	169630220	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr4:169630220G>A	ENST00000335742.7	+	9	1754	c.397G>A	c.(397-399)Gat>Aat	p.D133N	PALLD_ENST00000505667.1_Missense_Mutation_p.D515N|PALLD_ENST00000512127.1_Missense_Mutation_p.D133N|PALLD_ENST00000261509.6_Missense_Mutation_p.D515N			Q8WX93	PALLD_HUMAN	palladin, cytoskeletal associated protein	515					cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			breast(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(18)|ovary(3)|prostate(3)|skin(4)	48		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		TTTCCCTGAAGATGCAGGGAT	0.423000									Pancreatic Cancer, Familial Clustering of				45	101					0	0	1	0	0
CALCR	799	broad.mit.edu	37	7	93063567	93063567	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr7:93063567C>G	ENST00000359558.2	-	15	1590	c.1291G>C	c.(1291-1293)Gag>Cag	p.E431Q	CALCR_ENST00000421592.1_Missense_Mutation_p.E413Q|CALCR_ENST00000426151.1_Missense_Mutation_p.E397Q|CALCR_ENST00000360249.4_Missense_Mutation_p.E413Q|CALCR_ENST00000394441.1_Missense_Mutation_p.E397Q	NM_001164737.1	NP_001158209.1	P30988	CALCR_HUMAN	calcitonin receptor	413					activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin receptor activity|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(3)	45	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	ATGCTTACCTCATTGTTGCAG	0.353000													53	72					0	0	1	0	0
MST1L	11223	broad.mit.edu	37	1	17084309	17084309	+	RNA	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:17084309C>G	ENST00000455405.2	-	0	499																											ACATACCATTCAGGCGGCAGG	0.592000													33	452					0	0	1	0	0
NELFE	7936	broad.mit.edu	37	6	31921883	31921883	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr6:31921883C>T	ENST00000375429.3	-	9	1142	c.916G>A	c.(916-918)Gag>Aag	p.E306K	NELFE_ENST00000444811.2_Missense_Mutation_p.E276K|NELFE_ENST00000375425.5_Missense_Mutation_p.E313K	NM_002904.5	NP_002895.3			negative elongation factor complex member E																		TCTGCTGACTCCATCTTTTCA	0.493000													17	54					0	0	1	0	0
RNF111	54778	broad.mit.edu	37	15	59381927	59381927	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr15:59381927C>T	ENST00000348370.4	+	11	3045	c.2612C>T	c.(2611-2613)tCa>tTa	p.S871L	RNF111_ENST00000434298.1_Missense_Mutation_p.S880L|RNF111_ENST00000557998.1_Missense_Mutation_p.S871L|RNF111_ENST00000559209.1_Missense_Mutation_p.S880L|RNF111_ENST00000561186.1_Missense_Mutation_p.S880L	NM_001270528.1|NM_001270529.1|NM_017610.7	NP_001257457.1|NP_001257458.1|NP_060080.6	Q6ZNA4	RN111_HUMAN	ring finger protein 111	871					multicellular organismal development|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(11)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35				all cancers(107;0.194)		GATGGAACATCATTCAGAGGT	0.343000													107	132					0	0	1	0	0
LIPK	643414	broad.mit.edu	37	10	90492004	90492004	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr10:90492004G>A	ENST00000404190.1	+	4	492	c.492G>A	c.(490-492)aaG>aaA	p.K164K		NM_001080518.1	NP_001073987.1	Q5VXJ0	LIPK_HUMAN	lipase, family member K	164					lipid catabolic process	extracellular region	hydrolase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)	12		Colorectal(252;0.0381)		Colorectal(12;7.03e-05)|COAD - Colon adenocarcinoma(12;8.33e-05)		CTGGACAGAAGCGACTCTACT	0.423000													63	47					0	0	1	0	0
CPB2	1361	broad.mit.edu	37	13	46638814	46638814	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr13:46638814C>T	ENST00000181383.4	-	8	781	c.765G>A	c.(763-765)ctG>ctA	p.L255L	CPB2-AS1_ENST00000606991.1_RNA|CPB2-AS1_ENST00000415033.2_RNA|CPB2-AS1_ENST00000606351.1_RNA|CPB2_ENST00000439329.3_Silent_p.L218L|CPB2-AS1_ENST00000606243.1_RNA	NM_001872.3	NP_001863.3	Q96IY4	CBPB2_HUMAN	carboxypeptidase B2 (plasma)	255					blood coagulation|fibrinolysis|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			NS(1)|cervix(1)|large_intestine(3)|liver(1)|lung(9)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	21		Lung NSC(96;4.21e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|all_neural(104;0.235)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.44e-05)		AGTTCCTATTCAGGTCTGTTC	0.428000													72	75					0	0	1	0	0
FRMPD2	143162	broad.mit.edu	37	10	49376698	49376698	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr10:49376698G>A	ENST00000374201.3	-	27	3779	c.3477C>T	c.(3475-3477)gtC>gtT	p.V1159V	FRMPD2_ENST00000474573.1_Silent_p.V111V|FRMPD2_ENST00000463706.1_5'UTR|FRMPD2_ENST00000407470.4_Silent_p.V1127V|FRMPD2_ENST00000305531.3_Silent_p.V1134V	NM_001018071.3|NM_001042512.2	NP_001018081|NP_001035977.2	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2	1159	PDZ 3.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			NS(2)|autonomic_ganglia(2)|breast(5)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(15)|lung(24)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	66				Kidney(211;0.201)		GGAGGAGCGTGACTTCCTGTG	0.562000													81	15					0	0	1	0	0
PSMA1	5682	broad.mit.edu	37	11	14526776	14526776	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr11:14526776C>G	ENST00000530457.1	-	10	1209	c.679G>C	c.(679-681)Gaa>Caa	p.E227Q	PSMA1_ENST00000396393.1_Missense_Mutation_p.E252Q|PSMA1_ENST00000524606.1_5'UTR|PSMA1_ENST00000418988.2_Missense_Mutation_p.E258Q|PSMA1_ENST00000396394.2_Missense_Mutation_p.E252Q|PSMA1_ENST00000419365.2_3'UTR|PSMA1_ENST00000555531.1_3'UTR			P25786	PSA1_HUMAN	proteasome (prosome, macropain) subunit, alpha type, 1	252					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|polysome|proteasome core complex, alpha-subunit complex	protein binding|RNA binding|threonine-type endopeptidase activity			large_intestine(1)|skin(1)|upper_aerodigestive_tract(1)	3						TCTGCAGGTTCATCAGCAGGT	0.328000													72	119					0	0	1	0	0
CHD7	55636	broad.mit.edu	37	8	61655219	61655219	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr8:61655219C>T	ENST00000423902.2	+	2	1707	c.1228C>T	c.(1228-1230)Cct>Tct	p.P410S	CHD7_ENST00000524602.1_Missense_Mutation_p.P410S|CHD7_ENST00000525508.1_Missense_Mutation_p.P410S	NM_017780.3	NP_060250.2	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	410	Pro-rich.				central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(8)|cervix(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(16)|lung(49)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(3)	123		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			AGGCACTCCTCCTCCACAAGT	0.532000													36	113					0	0	1	0	0
TBCD	6904	broad.mit.edu	37	17	80755631	80755631	+	Splice_Site	SNP	A	A	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr17:80755631A>T	ENST00000355528.4	+	8	901		c.e8-1		TBCD_ENST00000539345.2_Splice_Site|TBCD_ENST00000397466.2_Splice_Site	NM_005993.4	NP_005984.3	Q9BTW9	TBCD_HUMAN	tubulin folding cofactor D						'de novo' posttranslational protein folding|adherens junction assembly|negative regulation of cell-substrate adhesion|negative regulation of microtubule polymerization|post-chaperonin tubulin folding pathway|tight junction assembly	adherens junction|cytoplasm|lateral plasma membrane|microtubule|tight junction	beta-tubulin binding|chaperone binding|GTPase activator activity	p.?(1)				Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0266)|all_epithelial(8;0.0696)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.18)			TTTTTTTTTTAGGCACAAATA	0.264000													5	40					0	0	1	0	0
C6orf1	221491	broad.mit.edu	37	6	34214471	34214471	+	Silent	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr6:34214471G>C	ENST00000476320.1	-	5	982	c.300C>G	c.(298-300)ctC>ctG	p.L100L	C6orf1_ENST00000413013.2_Silent_p.L80L|C6orf1_ENST00000468145.1_Silent_p.L100L|C6orf1_ENST00000394990.4_Silent_p.L100L|C6orf1_ENST00000335352.3_Silent_p.L80L|C6orf1_ENST00000481533.1_Silent_p.L100L	NM_001008703.1	NP_001008703.1	Q86T20	CF001_HUMAN	chromosome 6 open reading frame 1	100						extracellular region				endometrium(1)|prostate(1)	2		Ovarian(999;0.0228)		BRCA - Breast invasive adenocarcinoma(397;1.11e-10)		GGGAGAAATGGAGACCCAGCA	0.647000											OREG0017364	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	34					0	0	1	0	0
RGS9	8787	broad.mit.edu	37	17	63156425	63156425	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr17:63156425C>G	ENST00000449996.3	+	4	352	c.280C>G	c.(280-282)Ctc>Gtc	p.L94V	RGS9_ENST00000262406.9_Missense_Mutation_p.L94V|RGS9_ENST00000577186.1_3'UTR|RGS9_ENST00000443584.3_Missense_Mutation_p.L94V	NM_001081955.2	NP_001075424.1	O75916	RGS9_HUMAN	regulator of G-protein signaling 9	94	DEP.				intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(8)|liver(2)|lung(12)|ovary(2)|prostate(3)|skin(3)	41						GAATCTCATTCTCAAGCCTGA	0.478000													73	117					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62285805	62285805	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr11:62285805C>T	ENST00000378024.4	-	5	16358	c.16084G>A	c.(16084-16086)Gat>Aat	p.D5362N	AHNAK_ENST00000530124.1_Intron|AHNAK_ENST00000257247.7_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	5362					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				AGTGTCACATCTGGTGCCCCA	0.542000													45	72					0	0	1	0	0
RFTN1	23180	broad.mit.edu	37	3	16411602	16411602	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:16411602G>A	ENST00000334133.4	-	6	1283	c.1011C>T	c.(1009-1011)ttC>ttT	p.F337F	RFTN1_ENST00000483671.1_5'UTR|RFTN1_ENST00000432519.1_Silent_p.F301F	NM_015150.1	NP_055965.1	Q14699	RFTN1_HUMAN	raftlin, lipid raft linker 1	337						plasma membrane				central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(8)|lung(8)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	38						TTCCAAGGTAGAAGACTGCGT	0.493000													64	110					0	0	1	0	0
MROH9	80133	broad.mit.edu	37	1	170952562	170952562	+	Splice_Site	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:170952562G>C	ENST00000367759.4	+	9	770		c.e9-1		MROH9_ENST00000367758.3_Splice_Site	NM_001163629.1	NP_001157101.1			maestro heat-like repeat family member 9																		TAACAAAGCAGATATTGGAAC	0.358000													10	37					0	0	1	0	0
DHX57	90957	broad.mit.edu	37	2	39088479	39088479	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:39088479C>T	ENST00000295373.6	-	5	1199	c.1073G>A	c.(1072-1074)cGa>cAa	p.R358Q	DHX57_ENST00000479345.2_5'UTR	NM_198963.1	NP_945314.1	Q6P158	DHX57_HUMAN	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	358							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(20)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	62		all_hematologic(82;0.248)				TTTAGAAAATCGAATTTCAAG	0.373000													34	71					0	0	1	0	0
STK3	6788	broad.mit.edu	37	8	99786971	99786971	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr8:99786971C>T	ENST00000523601.1	-	4	586	c.187G>A	c.(187-189)Gaa>Aaa	p.E63K	STK3_ENST00000419617.2_Missense_Mutation_p.E35K	NM_001256312.1	NP_001243241.1	Q13188	STK3_HUMAN	serine/threonine kinase 3	35	Protein kinase.				apoptosis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of apoptosis	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein dimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	17	Breast(36;2.4e-06)	Breast(495;0.106)	OV - Ovarian serous cystadenocarcinoma(57;0.0382)	KIRC - Kidney renal clear cell carcinoma(542;9.44e-06)		ACTTACCCTTCTCCAAGCTTC	0.279000													19	42					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181741346	181741346	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:181741346C>T	ENST00000526775.1	+	36	5226	c.5061C>T	c.(5059-5061)ttC>ttT	p.F1687F	CACNA1E_ENST00000367567.4_Silent_p.F1313F|CACNA1E_ENST00000367570.1_Silent_p.F1706F|CACNA1E_ENST00000367573.2_Silent_p.F1706F|CACNA1E_ENST00000360108.3_Silent_p.F1687F|CACNA1E_ENST00000357570.5_Silent_p.F1657F|CACNA1E_ENST00000358338.5_Silent_p.F1638F	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1706					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						TTGTCTCCTTCATCTTCTTCT	0.542000													56	72					0	0	1	0	0
ERH	2079	broad.mit.edu	37	14	69847305	69847305	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr14:69847305C>G	ENST00000557016.1	-	4	658	c.265G>C	c.(265-267)Gag>Cag	p.E89Q	ERH_ENST00000216520.6_5'UTR	NM_004450.2	NP_004441.1	P84090	ERH_HUMAN	enhancer of rudimentary homolog (Drosophila)	89					cell cycle|pyrimidine nucleoside metabolic process	midbody	protein binding								all cancers(60;0.00365)|BRCA - Breast invasive adenocarcinoma(234;0.0137)|OV - Ovarian serous cystadenocarcinoma(108;0.0507)		TAGATCTTCTCTTTAATCCAG	0.507000													39	83					0	0	1	0	0
TNFRSF1A	7132	broad.mit.edu	37	12	6439066	6439066	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr12:6439066C>T	ENST00000162749.2	-	9	1234	c.935G>A	c.(934-936)aGa>aAa	p.R312K	TNFRSF1A_ENST00000540022.1_Missense_Mutation_p.R269K	NM_001065.3	NP_001056.1	P19438	TNR1A_HUMAN	tumor necrosis factor receptor superfamily, member 1A	312					apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|inflammatory response|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of inflammatory response|positive regulation of transcription from RNA polymerase II promoter|prostaglandin metabolic process	extracellular region|integral to plasma membrane|membrane raft	tumor necrosis factor receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	19						TGCCACCTCTCTGCGGGGAGC	0.657000													7	10					0	0	1	0	0
DCLRE1B	64858	broad.mit.edu	37	1	114454317	114454317	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:114454317G>A	ENST00000369563.3	+	4	1549	c.1103G>A	c.(1102-1104)aGa>aAa	p.R368K	DCLRE1B_ENST00000466480.1_3'UTR	NM_022836.3	NP_073747.1	Q9H816	DCR1B_HUMAN	DNA cross-link repair 1B	368					cell cycle checkpoint|DNA repair|protection from non-homologous end joining at telomere|telomeric 3' overhang formation|telomeric loop formation	centrosome|chromosome, telomeric region|nucleus	5'-3' exonuclease activity|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(2)|liver(2)|lung(6)|stomach(1)	18	Lung SC(450;0.184)	all_cancers(81;1.46e-05)|all_epithelial(167;2.42e-05)|all_lung(203;0.000353)|Lung NSC(69;0.000518)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CAAGCTGACAGAGACTCAAAG	0.498000								Other identified genes with known or suspected DNA repair function					56	73					0	0	1	0	0
ARHGEF4	50649	broad.mit.edu	37	2	131799445	131799445	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:131799445C>T	ENST00000392953.3	+	10	1914	c.1395C>T	c.(1393-1395)atC>atT	p.I465I	ARHGEF4_ENST00000525839.1_Silent_p.I465I|ARHGEF4_ENST00000428230.2_Intron|ARHGEF4_ENST00000355771.3_Silent_p.I394I|ARHGEF4_ENST00000409303.1_Silent_p.I405I|ARHGEF4_ENST00000326016.5_Silent_p.I465I	NM_032995.1	NP_127462.1	Q9NR80	ARHG4_HUMAN	Rho guanine nucleotide exchange factor (GEF) 4	465	DH.				apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|lamellipodium assembly|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|ruffle membrane	protein domain specific binding|Rac guanyl-nucleotide exchange factor activity			NS(1)|breast(4)|cervix(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(3)|pancreas(1)|prostate(1)|skin(4)	29		Prostate(154;0.055)		BRCA - Breast invasive adenocarcinoma(221;0.097)		CCCAGCTCATCAACGAGCGGA	0.567000													33	68					0	0	1	0	0
ANXA7	310	broad.mit.edu	37	10	75157941	75157941	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr10:75157941C>G	ENST00000372921.5	-	3	313	c.257G>C	c.(256-258)gGa>gCa	p.G86A	ANXA7_ENST00000492380.1_5'UTR|ANXA7_ENST00000535178.1_Intron	NM_001156.3	NP_001147.1	P20073	ANXA7_HUMAN	annexin A7		Repeat-rich region.						calcium ion binding|calcium-dependent phospholipid binding|calcium-dependent protein binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	26	Prostate(51;0.0119)					TAACTCACCTCCGGGATAGGA	0.542000													17	19					0	0	1	0	0
ZNF227	7770	broad.mit.edu	37	19	44739864	44739864	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:44739864G>A	ENST00000313040.7	+	6	1486	c.1281G>A	c.(1279-1281)caG>caA	p.Q427Q	ZNF227_ENST00000391961.2_Silent_p.Q376Q|ZNF227_ENST00000589005.1_Silent_p.Q376Q	NM_182490.1	NP_872296.1	Q86WZ6	ZN227_HUMAN	zinc finger protein 227	427					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(12)|ovary(2)|stomach(1)|urinary_tract(1)	24		Prostate(69;0.0435)				ACATCCATCAGAGAGTCCACA	0.498000													51	93					0	0	1	0	0
ZNF608	57507	broad.mit.edu	37	5	124080087	124080087	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr5:124080087C>A	ENST00000306315.5	-	1	1031	c.596G>T	c.(595-597)cGa>cTa	p.R199L	ZNF608_ENST00000504926.1_Intron	NM_020747.2	NP_065798.2	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	199						intracellular	zinc ion binding			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(12)|ovary(3)|skin(6)|urinary_tract(1)	46		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		CTTGGCGCCTCGGCTGCTCTG	0.622000													35	78					2.42023e-17	2.51689e-17	1	1	0
CACNA1E	777	broad.mit.edu	37	1	181767826	181767826	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:181767826C>T	ENST00000526775.1	+	46	6777	c.6612C>T	c.(6610-6612)atC>atT	p.I2204I	CACNA1E_ENST00000367567.4_Silent_p.I1830I|CACNA1E_ENST00000367570.1_Silent_p.I2223I|CACNA1E_ENST00000367573.2_Silent_p.I2266I|CACNA1E_ENST00000360108.3_Silent_p.I2247I|CACNA1E_ENST00000357570.5_Silent_p.I2217I|CACNA1E_ENST00000358338.5_Silent_p.I2155I	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	2266					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CCAACACCATCGGCTCAGCCC	0.672000													8	16					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178936082	178936082	+	Missense_Mutation	SNP	G	G	A	rs121913273		TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:178936082G>A	ENST00000263967.3	+	10	1781	c.1624G>A	c.(1624-1626)Gaa>Aaa	p.E542K		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	542	PI3K helical.		E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).|E -> V (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(545)|p.E542Q(10)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCCTCTCTCTGAAATCACTGA	0.333000	E542K(BT483_BREAST)|E542K(CAL51_BREAST)|E542K(HGC27_STOMACH)|E542K(IM95_STOMACH)|E542K(JHUEM1_ENDOMETRIUM)|E542K(NCIH1341_LUNG)|E542K(SW948_LARGE_INTESTINE)|E542K(T84_LARGE_INTESTINE)|E542K(VMCUB1_URINARY_TRACT)	57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			31	63					0	0	1	0	0
ZNF430	80264	broad.mit.edu	37	19	21239683	21239683	+	Nonsense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:21239683C>G	ENST00000261560.5	+	5	750	c.569C>G	c.(568-570)tCa>tGa	p.S190*		NM_001172671.1|NM_025189.3	NP_001166142.1|NP_079465.3	Q9H8G1	ZN430_HUMAN	zinc finger protein 430	190					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(8)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	23						TATAAATTTTCAAATCCAAAT	0.294000													24	46					0	0	1	0	0
DEGS1	8560	broad.mit.edu	37	1	224378016	224378016	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:224378016C>T	ENST00000323699.4	+	2	986	c.820C>T	c.(820-822)Cca>Tca	p.P274S	DEGS1_ENST00000391877.3_Missense_Mutation_p.P274S	NM_003676.3	NP_003667.1	O15121	DEGS1_HUMAN	delta(4)-desaturase, sphingolipid 1	274					sphingolipid metabolic process|unsaturated fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	electron carrier activity|protein binding|sphingolipid delta-4 desaturase activity			breast(1)|kidney(3)|large_intestine(2)|lung(4)	10	Breast(184;0.193)			GBM - Glioblastoma multiforme(131;0.00643)		AAAAAGTCTTCCACTGGTAAG	0.383000													26	98					0	0	1	0	0
TTLL5	23093	broad.mit.edu	37	14	76219287	76219287	+	Silent	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr14:76219287C>G	ENST00000298832.9	+	18	1744	c.1539C>G	c.(1537-1539)ctC>ctG	p.L513L	TTLL5_ENST00000554510.1_Silent_p.L9L|TTLL5_ENST00000556893.1_Silent_p.L51L|TTLL5_ENST00000557636.1_Silent_p.L527L|TTLL5_ENST00000555422.1_3'UTR	NM_015072.4	NP_055887.3	Q6EMB2	TTLL5_HUMAN	tubulin tyrosine ligase-like family, member 5	513					protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			NS(2)|breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(3)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(2)	50				BRCA - Breast invasive adenocarcinoma(234;0.029)		CAACACGCCTCTTCCAGGACA	0.378000													66	113					0	0	1	0	0
ZFP37	7539	broad.mit.edu	37	9	115805223	115805223	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr9:115805223G>A	ENST00000374227.3	-	4	1702	c.1675C>T	c.(1675-1677)Cac>Tac	p.H559Y	ZFP37_ENST00000555206.1_Missense_Mutation_p.H560Y|ZFP37_ENST00000553380.1_Missense_Mutation_p.H574Y	NM_001282515.1|NM_001282518.1	NP_001269444.1|NP_001269447.1	Q9Y6Q3	ZFP37_HUMAN	ZFP37 zinc finger protein	559						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	38						ACAATGAGGTGAGACTTTTGG	0.378000													56	89					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73375361	73375361	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr10:73375361C>G	ENST00000224721.6	+	9	953	c.948C>G	c.(946-948)atC>atG	p.I316M	CDH23_ENST00000461841.3_Missense_Mutation_p.I356M|CDH23_ENST00000299366.7_Missense_Mutation_p.I356M|CDH23_ENST00000398809.4_Missense_Mutation_p.I311M|CDH23_ENST00000398842.3_Missense_Mutation_p.I311M	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	311	Cadherin 3.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						ATGGCTTCATCCTGACTGTGA	0.597000													13	39					0	0	1	0	0
PI4KAP2	375133	broad.mit.edu	37	22	21828948	21828948	+	RNA	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr22:21828948C>T	ENST00000450651.1	-	0	1860																				endometrium(3)|urinary_tract(1)	4						CGCGCTCAGTCATGTTGGGGC	0.627000													10	15					0	0	1	0	0
TSGA10IP	254187	broad.mit.edu	37	11	65721160	65721160	+	RNA	SNP	G	G	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr11:65721160G>T	ENST00000532620.1	+	0	1505				TSGA10IP_ENST00000608857.1_RNA			Q3SY00	T10IP_HUMAN	testis specific, 10 interacting protein											endometrium(2)|kidney(3)|lung(9)	14						TACGCACCCAGAGGGAGCCGG	0.741000													23	29					2.89027e-11	2.9513e-11	1	1	0
CD209	30835	broad.mit.edu	37	19	7810478	7810478	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:7810478G>A	ENST00000315599.7	-	4	696	c.674C>T	c.(673-675)gCa>gTa	p.A225V	CD209_ENST00000394173.4_Intron|CD209_ENST00000601951.1_Missense_Mutation_p.A201V|CD209_ENST00000394161.5_Intron|CD209_ENST00000354397.6_Missense_Mutation_p.A225V|CD209_ENST00000593660.1_Intron|CD209_ENST00000204801.8_Missense_Mutation_p.A181V|CD209_ENST00000315591.8_Missense_Mutation_p.A201V|CD209_ENST00000593821.1_Intron|CD209_ENST00000601256.1_Missense_Mutation_p.A201V|CD209_ENST00000602261.1_Intron|CD209_ENST00000301357.8_Intron	NM_001144895.1|NM_001144897.1|NM_021155.3	NP_001138367.1|NP_001138369.1|NP_066978.1	Q9NNX6	CD209_HUMAN	CD209 molecule	225	7 X approximate tandem repeats.				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding			endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						CTCACCCACTGCAGCCTTCAG	0.562000													53	112					0	0	1	0	0
YIPF2	78992	broad.mit.edu	37	19	11034075	11034075	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:11034075G>C	ENST00000586748.1	-	9	1015	c.843C>G	c.(841-843)ttC>ttG	p.F281L	YIPF2_ENST00000590329.1_Missense_Mutation_p.F242L|YIPF2_ENST00000253031.2_Missense_Mutation_p.F281L			Q9BWQ6	YIPF2_HUMAN	Yip1 domain family, member 2	281						integral to membrane|transport vesicle				cervix(1)|endometrium(1)|lung(3)|ovary(2)	7						GCGACTGGAAGAAGTACAACT	0.652000													36	69					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26434459	26434459	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr10:26434459G>C	ENST00000265944.5	+	22	2667	c.2501G>C	c.(2500-2502)gGa>gCa	p.G834A	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	834	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						CATTATGCAGGAAAGGTAAGA	0.318000													23	47					0	0	1	0	0
PDS5B	23047	broad.mit.edu	37	13	33327482	33327482	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr13:33327482C>G	ENST00000315596.10	+	25	2935	c.2749C>G	c.(2749-2751)Caa>Gaa	p.Q917E		NM_015032.3	NP_055847.1	Q9NTI5	PDS5B_HUMAN	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	917					cell division|cell proliferation|mitotic sister chromatid cohesion|negative regulation of cell proliferation	chromatin|nucleus	ATP binding|DNA binding|identical protein binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(14)|lung(14)|ovary(5)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	62		Lung SC(185;0.0367)		all cancers(112;5.55e-06)|Epithelial(112;2.7e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00303)|BRCA - Breast invasive adenocarcinoma(63;0.0204)		TGAATGCTATCAAGTAAGACA	0.368000													112	103					0	0	1	0	0
FAM134A	79137	broad.mit.edu	37	2	220043729	220043729	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:220043729C>A	ENST00000430297.2	+	2	503	c.367C>A	c.(367-369)Cgc>Agc	p.R123S		NM_024293.4	NP_077269.3	Q8NC44	F134A_HUMAN	family with sequence similarity 134, member A	123						endoplasmic reticulum|integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)	19		Renal(207;0.0915)		Epithelial(149;8.92e-07)|all cancers(144;0.000151)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CTGGCAGCCTCGCTTTCTCCC	0.537000													100	66					9.07443e-57	9.76691e-57	1	1	0
STEAP4	79689	broad.mit.edu	37	7	87912158	87912158	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr7:87912158G>A	ENST00000380079.4	-	3	883	c.782C>T	c.(781-783)cCt>cTt	p.P261L	AC003991.3_ENST00000600908.1_RNA|STEAP4_ENST00000414498.1_Missense_Mutation_p.P261L|AC003991.3_ENST00000447758.1_RNA|AC003991.3_ENST00000595121.1_RNA|AC003991.3_ENST00000434733.1_RNA|STEAP4_ENST00000301959.5_Intron	NM_001205315.1|NM_024636.3	NP_001192244.1|NP_078912.2	Q687X5	STEA4_HUMAN	STEAP family member 4	261	Ferric oxidoreductase.				fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(3)	15	Esophageal squamous(14;0.00802)					AATAACACCAGGGAGGTAAAC	0.433000													51	71					0	0	1	0	0
NELFE	7936	broad.mit.edu	37	6	31921542	31921542	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr6:31921542C>G	ENST00000375429.3	-	10	1235	c.1009G>C	c.(1009-1011)Gat>Cat	p.D337H	NELFE_ENST00000444811.2_Missense_Mutation_p.D307H|NELFE_ENST00000375425.5_Missense_Mutation_p.D344H	NM_002904.5	NP_002895.3			negative elongation factor complex member E																		GTAGCGGCATCCAGCATGGGC	0.572000													61	128					0	0	1	0	0
PDCD2L	84306	broad.mit.edu	37	19	34912448	34912448	+	Silent	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:34912448C>G	ENST00000246535.3	+	6	869	c.822C>G	c.(820-822)ctC>ctG	p.L274L	PDCD2L_ENST00000587065.2_5'UTR	NM_032346.1	NP_115722.1	Q9BRP1	PDD2L_HUMAN	programmed cell death 2-like	274						cytoplasm				breast(2)|kidney(1)|large_intestine(4)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)			GAGAGCCACTCTTTTTGACCT	0.507000													140	243					0	0	1	0	0
KIF21A	55605	broad.mit.edu	37	12	39716623	39716623	+	Nonsense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr12:39716623G>C	ENST00000395670.3	-	26	3937	c.3518C>G	c.(3517-3519)tCa>tGa	p.S1173*	KIF21A_ENST00000361961.3_Nonsense_Mutation_p.S1160*|KIF21A_ENST00000544797.2_Nonsense_Mutation_p.S1153*|KIF21A_ENST00000361418.5_Nonsense_Mutation_p.S1173*|KIF21A_ENST00000541463.2_Nonsense_Mutation_p.S1137*			Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	1173					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(41)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	86		Lung NSC(34;0.179)|all_lung(34;0.213)				ACTAGTGTCTGAAGCTAGTTC	0.483000													56	101					0	0	1	0	0
OSBPL3	26031	broad.mit.edu	37	7	24901270	24901270	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr7:24901270G>A	ENST00000313367.2	-	10	1440	c.989C>T	c.(988-990)tCt>tTt	p.S330F	OSBPL3_ENST00000353930.1_Missense_Mutation_p.S330F|OSBPL3_ENST00000409069.1_Missense_Mutation_p.S299F|OSBPL3_ENST00000396431.1_Missense_Mutation_p.S299F|OSBPL3_ENST00000352860.1_Missense_Mutation_p.S299F|OSBPL3_ENST00000396429.1_Missense_Mutation_p.S330F|OSBPL3_ENST00000431825.2_Missense_Mutation_p.S299F	NM_015550.2	NP_056365.1	Q9H4L5	OSBL3_HUMAN	oxysterol binding protein-like 3	330					lipid transport		lipid binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(19)|prostate(1)|skin(3)|urinary_tract(1)	43						TTGCATTTTAGAAAACTCTGA	0.358000													90	143					0	0	1	0	0
SNHG12	85028	broad.mit.edu	37	1	28907175	28907175	+	RNA	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:28907175G>A	ENST00000488745.1	-	0	1013				SNHG12_ENST00000475441.1_RNA|SNHG12_ENST00000531126.1_RNA|SNHG12_ENST00000483436.1_RNA																							AGCAAAATGAGAACAACTGTC	0.423000													7	16					0	0	1	0	0
BSND	7809	broad.mit.edu	37	1	55464937	55464937	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:55464937G>A	ENST00000371265.4	+	1	332	c.78G>A	c.(76-78)atG>atA	p.M26I		NM_057176.2	NP_476517.1	Q8WZ55	BSND_HUMAN	Bartter syndrome, infantile, with sensorineural deafness (Barttin)	26						basolateral plasma membrane|cytoplasm|integral to plasma membrane|protein complex				cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	17						CGTTCCTCATGAGCCATGATC	0.617000													39	43					0	0	1	0	0
KIR2DL1	3802	broad.mit.edu	37	19	55286732	55286732	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:55286732G>A	ENST00000336077.6	+	4	526	c.486G>A	c.(484-486)agG>agA	p.R162R	KIR3DL1_ENST00000538269.1_Intron|KIR2DL1_ENST00000291633.7_Silent_p.R162R|CTB-61M7.1_ENST00000400864.3_RNA|KIR2DL3_ENST00000434419.2_Intron|KIR3DL1_ENST00000541392.1_Intron|KIR2DL4_ENST00000396284.2_Intron|KIR3DL1_ENST00000402254.2_Intron	NM_014218.2	NP_055033.2	P43626	KI2L1_HUMAN	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1	162	Ig-like C2-type 2.				immune response|natural killer cell inhibitory signaling pathway	integral to plasma membrane	protein binding|receptor activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	17				GBM - Glioblastoma multiforme(193;0.0192)		ATCTATCCAGGGAAGGGGAGG	0.612000													75	29					0	0	1	0	0
TAS1R3	83756	broad.mit.edu	37	1	1266858	1266858	+	Missense_Mutation	SNP	G	G	A	rs137986343		TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:1266858G>A	ENST00000339381.5	+	1	165	c.133G>A	c.(133-135)Gag>Aag	p.E45K		NM_152228.1	NP_689414	Q7RTX0	TS1R3_HUMAN	taste receptor, type 1, member 3	45					detection of chemical stimulus involved in sensory perception of sweet taste|sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			kidney(2)|lung(8)|upper_aerodigestive_tract(1)|urinary_tract(1)	12	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.88e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.146)	Aspartame(DB00168)	CCCCCTGGGCGAGGCCGAGGA	0.697000													7	12					0	0	1	0	0
NGLY1	55768	broad.mit.edu	37	3	25820067	25820067	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:25820067C>A	ENST00000428257.1	-	2	351	c.244G>T	c.(244-246)Gag>Tag	p.E82*	NGLY1_ENST00000422724.2_Nonsense_Mutation_p.E5*|NGLY1_ENST00000280700.5_Nonsense_Mutation_p.E82*|NGLY1_ENST00000417874.2_Nonsense_Mutation_p.E40*|NGLY1_ENST00000396649.3_Nonsense_Mutation_p.E82*	NM_001145293.1	NP_001138765.1	Q96IV0	NGLY1_HUMAN	N-glycanase 1	82	PUB.				glycoprotein catabolic process	cytoplasm	metal ion binding|peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|prostate(2)|skin(1)	18						ATACTTACCTCTTCAAAGCCC	0.363000													48	72					4.25531e-23	4.46643e-23	1	1	0
TUBB6	84617	broad.mit.edu	37	18	12325380	12325380	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr18:12325380G>A	ENST00000317702.5	+	4	826	c.592G>A	c.(592-594)Gag>Aag	p.E198K	TUBB6_ENST00000590967.1_Intron|TUBB6_ENST00000591909.1_Intron|TUBB6_ENST00000591208.1_3'UTR			Q9BUF5	TBB6_HUMAN	tubulin, beta 6 class V	198					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|prostate(1)	14				READ - Rectum adenocarcinoma(1;0.0649)		GAATACAGACGAGACCTACTG	0.597000													90	126					0	0	1	0	0
PIKFYVE	200576	broad.mit.edu	37	2	209217435	209217435	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:209217435C>G	ENST00000264380.4	+	39	5931	c.5773C>G	c.(5773-5775)Cag>Gag	p.Q1925E		NM_015040.3	NP_055855.2	Q9Y2I7	FYV1_HUMAN	phosphoinositide kinase, FYVE finger containing	1925	Catalytic.|PIPK.				cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(14)|kidney(6)|large_intestine(25)|lung(40)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	107						TAAGAACTCTCAGAACAACAC	0.388000													68	42					0	0	1	0	0
PLEKHA8	84725	broad.mit.edu	37	7	30087528	30087528	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr7:30087528G>C	ENST00000449726.1	+	4	744	c.394G>C	c.(394-396)Gat>Cat	p.D132H	PLEKHA8_ENST00000396259.1_Missense_Mutation_p.D132H|PLEKHA8_ENST00000483799.1_3'UTR|PLEKHA8_ENST00000396257.2_Missense_Mutation_p.D132H|PLEKHA8_ENST00000258679.7_Missense_Mutation_p.D132H	NM_001197027.1	NP_001183956.1	Q96JA3	PKHA8_HUMAN	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8	132					protein transport	cytoplasm	glycolipid binding|glycolipid transporter activity			breast(4)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)	17						TCAGCAAGTAGATAAAACAAA	0.299000													62	93					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57335750	57335750	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:57335750C>G	ENST00000326441.9	-	4	637	c.274G>C	c.(274-276)Gag>Cag	p.E92Q	PEG3_ENST00000423103.2_Missense_Mutation_p.E92Q|ZIM2_ENST00000599935.1_5'UTR|PEG3_ENST00000593695.1_5'UTR|ZIM2_ENST00000593711.1_5'UTR|ZIM2_ENST00000221722.5_5'UTR|ZIM2_ENST00000601070.1_5'UTR|PEG3_ENST00000598410.1_5'UTR|PEG3_ENST00000594706.1_5'UTR|ZIM2_ENST00000391708.3_5'UTR	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	92	SCAN box.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		AGGTACTGCTCAAGGACCAAG	0.542000													51	103					0	0	1	0	0
TMC6	11322	broad.mit.edu	37	17	76120185	76120185	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr17:76120185G>A	ENST00000590602.1	-	9	1126	c.967C>T	c.(967-969)Ctg>Ttg	p.L323L	TMC6_ENST00000306591.7_Silent_p.L323L|TMC6_ENST00000392467.3_Silent_p.L323L|TMC6_ENST00000322933.4_5'UTR|TMC6_ENST00000322914.3_Silent_p.L323L|TMC6_ENST00000589553.1_Silent_p.L96L			Q7Z403	TMC6_HUMAN	transmembrane channel-like 6	323						endoplasmic reticulum membrane|integral to membrane				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	14			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			CTGCCATCCAGGGGGCTGCCA	0.617000													28	40					0	0	1	0	0
PPFIBP1	8496	broad.mit.edu	37	12	27803008	27803008	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr12:27803008G>C	ENST00000318304.8	+	7	820	c.537G>C	c.(535-537)ttG>ttC	p.L179F	PPFIBP1_ENST00000228425.6_Missense_Mutation_p.L179F|PPFIBP1_ENST00000542629.1_Missense_Mutation_p.L179F|PPFIBP1_ENST00000537927.1_Missense_Mutation_p.L26F	NM_001198916.1|NM_177444.2	NP_001185845.1|NP_803193	Q86W92	LIPB1_HUMAN	PTPRF interacting protein, binding protein 1 (liprin beta 1)	179					cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(13)|prostate(2)|skin(1)	32	Lung SC(9;0.0873)					TATCTAACTTGAAGTTGAAAC	0.388000													37	47					0	0	1	0	0
AHR	196	broad.mit.edu	37	7	17378992	17378992	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr7:17378992G>T	ENST00000242057.4	+	10	2186	c.1543G>T	c.(1543-1545)Gac>Tac	p.D515Y	AHR_ENST00000492120.1_3'UTR	NM_001621.4	NP_001612.1	P35869	AHR_HUMAN	aryl hydrocarbon receptor	515					apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(11)|ovary(1)|pancreas(1)|urinary_tract(3)	33	Lung NSC(10;0.0392)|all_lung(11;0.0754)					TGAGCAAATTGACCAGCCTCA	0.393000													44	104					5.48756e-27	5.80481e-27	1	1	0
POM121L9P	29774	broad.mit.edu	37	22	24658509	24658509	+	RNA	SNP	C	C	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr22:24658509C>A	ENST00000414583.2	+	0	2926					NR_003714.1																						TCTCGCTCATCATCACCGACA	0.562000													18	17					2.35188e-11	2.40881e-11	1	1	0
MUM1	84939	broad.mit.edu	37	19	1376552	1376552	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:1376552G>T	ENST00000311401.5	+	14	2292	c.1906G>T	c.(1906-1908)Gag>Tag	p.E636*	MUM1_ENST00000344663.3_Nonsense_Mutation_p.E705*|MUM1_ENST00000415183.3_3'UTR|MUM1_ENST00000591453.1_3'UTR|MUM1_ENST00000591806.1_Nonsense_Mutation_p.E705*			Q2TAK8	MUM1_HUMAN	melanoma associated antigen (mutated) 1	704					chromatin organization|DNA repair	nucleus	nucleosome binding|protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTCCTTGAAGAGCGGAACCG	0.507000													38	79					1.62957e-23	1.71307e-23	1	1	0
GALNT8	26290	broad.mit.edu	37	12	4881658	4881658	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr12:4881658G>A	ENST00000252318.2	+	11	2146	c.1809G>A	c.(1807-1809)aaG>aaA	p.K603K		NM_017417.1	NP_059113.1	Q9NY28	GALT8_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)	603	Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	35						TGGAGATGAAGAAGGATCTTT	0.527000													29	73					0	0	1	0	0
AHR	196	broad.mit.edu	37	7	17378759	17378759	+	Missense_Mutation	SNP	G	G	C	rs138430398		TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr7:17378759G>C	ENST00000242057.4	+	10	1953	c.1310G>C	c.(1309-1311)gGa>gCa	p.G437A	AHR_ENST00000492120.1_3'UTR	NM_001621.4	NP_001612.1	P35869	AHR_HUMAN	aryl hydrocarbon receptor	437					apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding	p.G437V(1)		NS(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(11)|ovary(1)|pancreas(1)|urinary_tract(3)	33	Lung NSC(10;0.0392)|all_lung(11;0.0754)					GGCACTAGTGGAAAAGACTCT	0.438000													50	97					0	0	1	0	0
CNTROB	116840	broad.mit.edu	37	17	7836433	7836433	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr17:7836433C>T	ENST00000380262.3	+	1	961	c.36C>T	c.(34-36)ctC>ctT	p.L12L	CNTROB_ENST00000380255.3_Silent_p.L12L|CNTROB_ENST00000565740.1_Silent_p.L12L|CNTROB_ENST00000563694.1_Silent_p.L12L	NM_001037144.5	NP_001032221.1	Q8N137	CNTRB_HUMAN	centrobin, centrosomal BRCA2 interacting protein	12					centriole replication|centrosome separation|cytokinesis	centriole	protein domain specific binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(9)	25		Prostate(122;0.173)				GTTCACCCCTCGGGGCGGAGG	0.557000													64	106					0	0	1	0	0
USP24	23358	broad.mit.edu	37	1	55595163	55595163	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:55595163C>G	ENST00000294383.6	-	32	3621	c.3622G>C	c.(3622-3624)Gct>Cct	p.A1208P	USP24_ENST00000407756.1_Missense_Mutation_p.A1048P	NM_015306.2	NP_056121.2	Q9UPU5	UBP24_HUMAN	ubiquitin specific peptidase 24	1208					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|cervix(1)|endometrium(8)|kidney(13)|large_intestine(7)|lung(16)|ovary(6)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	60						AAACCGCCAGCTTTGAGGAAG	0.403000													10	35					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15726043	15726043	+	Missense_Mutation	SNP	C	C	G	rs149496502		TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr10:15726043C>G	ENST00000378076.3	-	4	881	c.528G>C	c.(526-528)caG>caC	p.Q176H		NM_003638.1	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8	176					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						CGCTGAAGTTCTGAATTGCTA	0.448000													33	87					0	0	1	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90162462	90162462	+	RNA	SNP	A	A	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr16:90162462A>G	ENST00000564451.1	+	0	1815				TUBB8P7_ENST00000567960.1_RNA														p.T398T(1)									ACTGGTACACAGGCGAGGGCA	0.522000													5	203					0	0	1	0	0
PIGC	5279	broad.mit.edu	37	1	172411277	172411277	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:172411277G>C	ENST00000367728.1	-	1	1949	c.486C>G	c.(484-486)atC>atG	p.I162M	C1orf105_ENST00000367727.4_Intron|PIGC_ENST00000258324.1_Missense_Mutation_p.I162M|PIGC_ENST00000344529.4_Missense_Mutation_p.I162M|PIGC_ENST00000484368.1_Intron			Q92535	PIGC_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class C	162					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			breast(1)|endometrium(1)|kidney(1)|lung(1)	4						AGTCAAAAAAGATGAGATGGC	0.473000													19	35					0	0	1	0	0
CDKAL1	54901	broad.mit.edu	37	6	20781488	20781488	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr6:20781488C>T	ENST00000274695.4	+	8	797	c.630C>T	c.(628-630)atC>atT	p.I210I	CDKAL1_ENST00000378610.1_Silent_p.I210I|CDKAL1_ENST00000378624.4_Silent_p.I140I|RP3-348I23.2_ENST00000421167.1_RNA	NM_017774.3	NP_060244.2	Q5VV42	CDKAL_HUMAN	CDK5 regulatory subunit associated protein 1-like 1	210					RNA modification	integral to membrane	4 iron, 4 sulfur cluster binding|metal ion binding|transferase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(14)|ovary(2)|stomach(1)	29	all_epithelial(95;0.0708)|Breast(50;0.131)|Ovarian(93;0.227)		OV - Ovarian serous cystadenocarcinoma(7;0.0241)|all cancers(50;0.123)|Epithelial(50;0.248)			TCATTTCCATCAATACCGGGT	0.388000													46	97					0	0	1	0	0
UTP14A	10813	broad.mit.edu	37	X	129058886	129058886	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chrX:129058886G>A	ENST00000394422.3	+	12	1492	c.1464G>A	c.(1462-1464)caG>caA	p.Q488Q	UTP14A_ENST00000371042.3_Silent_p.Q320Q|UTP14A_ENST00000371051.5_Silent_p.Q434Q|UTP14A_ENST00000425117.2_Silent_p.Q436Q|RP4-537K23.4_ENST00000432062.1_RNA	NM_006649.3	NP_006640.2	Q9BVJ6	UT14A_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)	488					rRNA processing	nucleolus|small-subunit processome	protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|liver(2)|lung(16)|ovary(3)|urinary_tract(1)	32						CCCAGGTCCAGAGAGAGGAAC	0.488000													116	44					0	0	1	0	0
KDM5A	5927	broad.mit.edu	37	12	442760	442760	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr12:442760C>T	ENST00000399788.2	-	12	1908	c.1546G>A	c.(1546-1548)Gag>Aag	p.E516K	KDM5A_ENST00000382815.4_Missense_Mutation_p.E516K	NM_001042603.1	NP_001036068.1	P29375	KDM5A_HUMAN	lysine (K)-specific demethylase 5A	516	JmjC.				chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(29)|ovary(1)|prostate(5)|skin(6)|stomach(1)|urinary_tract(2)	77						CTCATCACCTCCTCCAGTTGC	0.498000			T	NUP98	AML								57	89					0	0	1	0	0
CROCCP2	84809	broad.mit.edu	37	1	16945485	16945485	+	RNA	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:16945485C>T	ENST00000412962.1	-	0	2034																											CCTGCCGGCTCTGGGCATCTG	0.637000													18	211					0	0	1	0	0
PNPLA6	10908	broad.mit.edu	37	19	7619840	7619840	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:7619840G>A	ENST00000221249.6	+	25	3013	c.2582G>A	c.(2581-2583)cGa>cAa	p.R861Q	PNPLA6_ENST00000414982.3_Missense_Mutation_p.R909Q|PNPLA6_ENST00000600737.1_Missense_Mutation_p.R899Q|PNPLA6_ENST00000545201.2_Missense_Mutation_p.R834Q|PNPLA6_ENST00000450331.3_Missense_Mutation_p.R861Q	NM_006702.4	NP_006693.3	Q8IY17	PLPL6_HUMAN	patatin-like phospholipase domain containing 6	900					cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(14)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)	35						CTGCTCCACCGAGAGGAGGGC	0.677000													8	19					0	0	1	0	0
ERBB2	2064	broad.mit.edu	37	17	37868208	37868208	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr17:37868208C>T	ENST00000406381.2	+	10	1349	c.839C>T	c.(838-840)tCc>tTc	p.S280F	ERBB2_ENST00000269571.5_Missense_Mutation_p.S310F|ERBB2_ENST00000541774.1_Missense_Mutation_p.S295F|ERBB2_ENST00000540147.1_Missense_Mutation_p.S280F|ERBB2_ENST00000540042.1_Missense_Mutation_p.S280F|ERBB2_ENST00000584601.1_Missense_Mutation_p.S280F|ERBB2_ENST00000584450.1_Missense_Mutation_p.S310F|ERBB2_ENST00000445658.2_Missense_Mutation_p.S34F|ERBB2_ENST00000578199.1_Missense_Mutation_p.S280F	NM_001005862.1	NP_001005862.1	P04626	ERBB2_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	310					cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.S310F(6)|p.S310Y(1)		NS(1)|breast(16)|central_nervous_system(17)|endometrium(6)|haematopoietic_and_lymphoid_tissue(8)|kidney(4)|large_intestine(16)|liver(3)|lung(125)|ovary(18)|pancreas(1)|prostate(4)|skin(1)|stomach(14)|upper_aerodigestive_tract(9)|urinary_tract(4)	247	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	GACGTGGGATCCTGCACCCTC	0.582000		1	"""A, Mis, O"""		"""breast, ovarian, other tumour types, NSCLC, gastric"""					TCGA GBM(5;<1E-08)			112	229					0	0	1	0	0
NDUFB3	4709	broad.mit.edu	37	2	201943722	201943722	+	Silent	SNP	A	A	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:201943722A>G	ENST00000237889.4	+	2	440	c.117A>G	c.(115-117)aaA>aaG	p.K39K	NDUFB3_ENST00000454214.1_Silent_p.K39K|NDUFB3_ENST00000433898.1_Silent_p.K39K	NM_001257102.1|NM_002491.2	NP_001244031.1|NP_002482.1	O43676	NDUB3_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa	39					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			large_intestine(1)|lung(1)|urinary_tract(1)	3					NADH(DB00157)	TGGCTGCAAAAGGGCTAAGGG	0.393000													3	107					0	0	1	0	0
WDR81	124997	broad.mit.edu	37	17	1631404	1631404	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr17:1631404C>G	ENST00000409644.1	+	1	3151	c.3151C>G	c.(3151-3153)Ccc>Gcc	p.P1051A	RP11-961A15.1_ENST00000576540.1_RNA|WDR81_ENST00000446363.1_Intron|WDR81_ENST00000309182.5_5'UTR|WDR81_ENST00000419248.1_Intron|WDR81_ENST00000437219.2_Intron	NM_001163809.1	NP_001157281.1	B3KXU1	B3KXU1_HUMAN	WD repeat domain 81	380										cervix(1)|endometrium(1)|kidney(3)|lung(6)|ovary(2)|prostate(2)|skin(1)	16				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		GGAGGAGATTCCCATGGATGG	0.677000													5	15					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124349189	124349189	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr12:124349189T>C	ENST00000409039.3	+	39	6627	c.6602T>C	c.(6601-6603)aTg>aCg	p.M2201T		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2201	AAA 2 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GTGGAAAACATGAATTCTGTG	0.473000													13	38					0	0	1	0	0
KIAA0319L	79932	broad.mit.edu	37	1	35900587	35900587	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:35900587C>T	ENST00000325722.3	-	21	3292	c.3058G>A	c.(3058-3060)Gag>Aag	p.E1020K	KIAA0319L_ENST00000373266.4_Missense_Mutation_p.E457K	NM_024874.4	NP_079150.3	Q8IZA0	K319L_HUMAN	KIAA0319-like	1020						cytoplasmic vesicle part|integral to membrane	protein binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(12)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|urinary_tract(1)	34		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TTGCCCTTCTCTCGGTCTGGC	0.572000													30	33					0	0	1	0	0
RANBP2	5903	broad.mit.edu	37	2	109336129	109336129	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:109336129C>T	ENST00000283195.6	+	1	193	c.67C>T	c.(67-69)Cga>Tga	p.R23*		NM_006267.4	NP_006258.3	P49792	RBP2_HUMAN	RAN binding protein 2	23					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(34)	NS(1)|biliary_tract(1)|breast(3)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(21)|large_intestine(19)|lung(51)|pancreas(1)|prostate(8)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	129						CCCGTCGCCTCGACAGGTGAG	0.721000													4	16					0	0	1	0	0
STK35	140901	broad.mit.edu	37	20	2097983	2097983	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr20:2097983G>C	ENST00000381482.3	+	3	1835	c.1564G>C	c.(1564-1566)Gaa>Caa	p.E522Q	STK35_ENST00000246032.3_Missense_Mutation_p.E389Q|STK35_ENST00000400064.3_Intron			Q8TDR2	STK35_HUMAN	serine/threonine kinase 35	522	Protein kinase.					cytoplasm|nucleolus	ATP binding|protein serine/threonine kinase activity			large_intestine(2)|liver(2)|lung(6)|ovary(1)|prostate(2)	13						TGATGCCTTTGAACTTGAAAC	0.468000													37	78					0	0	1	0	0
RP11-146E13.4	0	broad.mit.edu	37	14	19857036	19857036	+	RNA	SNP	A	A	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr14:19857036A>G	ENST00000548109.1	+	0	72																											CTGGATAATAAAGTTCATCTC	0.373000													5	106					0	0	1	0	0
GPR64	10149	broad.mit.edu	37	X	19086862	19086862	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chrX:19086862G>A	ENST00000379878.3	-	3	332	c.91C>T	c.(91-93)Cat>Tat	p.H31Y	GPR64_ENST00000360279.4_Missense_Mutation_p.H31Y|GPR64_ENST00000379869.3_Missense_Mutation_p.H31Y|GPR64_ENST00000357544.3_Missense_Mutation_p.H31Y|GPR64_ENST00000356606.4_Missense_Mutation_p.H31Y|GPR64_ENST00000354791.3_Missense_Mutation_p.H31Y|GPR64_ENST00000340581.3_Missense_Mutation_p.H31Y|GPR64_ENST00000379876.1_Missense_Mutation_p.H31Y|GPR64_ENST00000379873.2_Missense_Mutation_p.H31Y|GPR64_ENST00000357991.3_Missense_Mutation_p.H31Y	NM_001184833.1	NP_001171762.1	Q8IZP9	GPR64_HUMAN	G protein-coupled receptor 64	31					neuropeptide signaling pathway|spermatogenesis	cytoplasm|integral to plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(18)|stomach(1)|urinary_tract(1)	42	Hepatocellular(33;0.183)					AGAACGACATGAAGACAAATG	0.363000													121	26					0	0	1	0	0
ARID1A	8289	broad.mit.edu	37	1	27059264	27059264	+	Nonsense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:27059264C>G	ENST00000324856.7	+	4	2272	c.1901C>G	c.(1900-1902)tCa>tGa	p.S634*	ARID1A_ENST00000374152.2_Nonsense_Mutation_p.S251*|ARID1A_ENST00000457599.2_Nonsense_Mutation_p.S634*	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	634					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		AGCCTTCAGTCAAGACCCTCC	0.483000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								63	65					0	0	1	0	0
GPR149	344758	broad.mit.edu	37	3	154147036	154147036	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:154147036C>T	ENST00000389740.2	-	1	468	c.369G>A	c.(367-369)gcG>gcA	p.A123A		NM_001038705.1	NP_001033794.1	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	123						integral to membrane|plasma membrane	G-protein coupled receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(22)|ovary(7)|prostate(1)|skin(1)|urinary_tract(2)	47			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			CTAGGAGAGTCGCCTTCAAGT	0.537000													23	48					0	0	1	0	0
MRGPRX1	259249	broad.mit.edu	37	11	18955407	18955407	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr11:18955407G>A	ENST00000302797.3	-	1	1149	c.925C>T	c.(925-927)Cct>Tct	p.P309S		NM_147199.3	NP_671732.3	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	309					acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|pancreas(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						ATTTCCTCAGGAAGCTGCCCT	0.582000													44	73					0	0	1	0	0
VCAM1	7412	broad.mit.edu	37	1	101186098	101186098	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:101186098C>T	ENST00000294728.2	+	2	232	c.131C>T	c.(130-132)tCa>tTa	p.S44L	VCAM1_ENST00000370119.4_Missense_Mutation_p.S44L|VCAM1_ENST00000370115.1_Missense_Mutation_p.S44L|VCAM1_ENST00000347652.2_Missense_Mutation_p.S44L	NM_001078.3	NP_001069.1	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1	44	Ig-like C2-type 1.				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(27)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	GACTCCGTCTCATTGACTTGC	0.453000													26	114					0	0	1	0	0
RBBP7	5931	broad.mit.edu	37	X	16887315	16887315	+	Silent	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chrX:16887315G>C	ENST00000380087.2	-	2	405	c.45C>G	c.(43-45)gtC>gtG	p.V15V	RBBP7_ENST00000404022.1_Silent_p.V15V|RBBP7_ENST00000380084.4_Silent_p.V59V			Q16576	RBBP7_HUMAN	retinoblastoma binding protein 7	15					cell proliferation|cellular heat acclimation|CenH3-containing nucleosome assembly at centromere|DNA replication|multicellular organismal development|negative regulation of cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex|NuRD complex	protein binding			biliary_tract(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(2)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	25	Hepatocellular(33;0.0997)					CTTCATTGATGACACGCTCCT	0.433000													62	21					0	0	1	0	0
FES	2242	broad.mit.edu	37	15	91436897	91436897	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr15:91436897C>T	ENST00000328850.3	+	17	2201	c.2059C>T	c.(2059-2061)Cgg>Tgg	p.R687W	FES_ENST00000394302.1_Missense_Mutation_p.R546W|FES_ENST00000394300.3_Missense_Mutation_p.R629W|FES_ENST00000444422.2_Missense_Mutation_p.R617W|FES_ENST00000414248.2_Missense_Mutation_p.R559W|FES_ENST00000450438.2_Missense_Mutation_p.R559W	NM_002005.3	NP_001996.1	P07332	FES_HUMAN	feline sarcoma oncogene	687	Protein kinase.				axon guidance|cell proliferation|peptidyl-tyrosine phosphorylation	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(2)|ovary(1)	3	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			CCTGGCTGCTCGGAACTGCCT	0.592000													17	45					0	0	1	0	0
TOR1AIP1	26092	broad.mit.edu	37	1	179887207	179887207	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:179887207G>C	ENST00000606911.2	+	10	1776	c.1585G>C	c.(1585-1587)Gaa>Caa	p.E529Q	TOR1AIP1_ENST00000435319.4_Missense_Mutation_p.E408Q|TOR1AIP1_ENST00000528443.2_Missense_Mutation_p.E530Q|TOR1AIP1_ENST00000271583.3_Missense_Mutation_p.E545Q			Q5JTV8	TOIP1_HUMAN	torsin A interacting protein 1							integral to membrane|nuclear inner membrane				breast(4)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(4)|ovary(2)|skin(1)|urinary_tract(1)	18						AAAGGAAGTTGAAGAAAAAGT	0.423000													59	55					0	0	1	0	0
GNA12	2768	broad.mit.edu	37	7	2883515	2883515	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr7:2883515C>T	ENST00000275364.3	-	1	443	c.281G>A	c.(280-282)cGc>cAc	p.R94H	GNA12_ENST00000544127.1_Missense_Mutation_p.R18H	NM_007353.2	NP_031379.2	Q03113	GNA12_HUMAN	guanine nucleotide binding protein (G protein) alpha 12	94					G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|Rho protein signal transduction	brush border membrane|heterotrimeric G-protein complex	D5 dopamine receptor binding|G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|signal transducer activity			endometrium(1)|large_intestine(5)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	13		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;1.02e-13)		GATGGTGTCGCGGAACTCCAG	0.701000													7	10					0	0	1	0	0
SBK2	646643	broad.mit.edu	37	19	56047475	56047475	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:56047475C>T	ENST00000413299.1	-	2	224	c.187G>A	c.(187-189)Gag>Aag	p.E63K	SBK2_ENST00000344158.3_Missense_Mutation_p.E63K	NM_001101401.2	NP_001094871.2	P0C263	SBK2_HUMAN	SH3 domain binding kinase family, member 2	63	Protein kinase.						ATP binding|protein serine/threonine kinase activity			endometrium(1)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	9						CGCACTTCCTCGTAGAGCTCG	0.657000													10	18					0	0	1	0	0
UNC5B	219699	broad.mit.edu	37	10	73050727	73050727	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr10:73050727C>T	ENST00000335350.6	+	9	1571	c.1155C>T	c.(1153-1155)ttC>ttT	p.F385F	UNC5B_ENST00000373192.4_Silent_p.F374F	NM_170744.4	NP_734465.2	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B (C. elegans)	385					apoptosis|axon guidance|regulation of apoptosis	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(4)|skin(4)	49						TGGCCATCTTCGTGGTCGTGG	0.642000													149	260					0	0	1	0	0
TTC9B	148014	broad.mit.edu	37	19	40724187	40724187	+	Silent	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:40724187G>C	ENST00000311308.6	-	1	119	c.102C>G	c.(100-102)ggC>ggG	p.G34G		NM_152479.5	NP_689692.2	Q8N6N2	TTC9B_HUMAN	tetratricopeptide repeat domain 9B	34	Pro-rich.						binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(2)	5						GGGAGCCCGAGCCTGGGCCCG	0.791000													6	1					0	0	1	0	0
MTSS1L	92154	broad.mit.edu	37	16	70698045	70698045	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr16:70698045C>T	ENST00000338779.6	-	15	2053	c.1779G>A	c.(1777-1779)gtG>gtA	p.V593V	FLJ00418_ENST00000597002.1_5'UTR	NM_138383.2	NP_612392.1	Q765P7	MTSSL_HUMAN	metastasis suppressor 1-like	593					filopodium assembly|signal transduction		actin binding|cytoskeletal adaptor activity|SH3 domain binding			breast(1)|central_nervous_system(2)|endometrium(1)|liver(1)|lung(1)|skin(1)	7						TGGGCGTCTTCACAGGGACGA	0.716000													17	7					0	0	1	0	0
ZNF335	63925	broad.mit.edu	37	20	44586517	44586517	+	Silent	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr20:44586517G>C	ENST00000322927.2	-	16	2404	c.2304C>G	c.(2302-2304)ctC>ctG	p.L768L	ZNF335_ENST00000426788.1_Silent_p.L613L	NM_022095.3	NP_071378.1	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	768					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(13)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	51		Myeloproliferative disorder(115;0.0122)				TGTCAGAACAGAGCAATGAGG	0.582000													43	81					0	0	1	0	0
ABT1	29777	broad.mit.edu	37	6	26598303	26598303	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr6:26598303C>T	ENST00000274849.1	+	2	434	c.403C>T	c.(403-405)Cgc>Tgc	p.R135C		NM_013375.3	NP_037507.1	Q9ULW3	ABT1_HUMAN	activator of basal transcription 1	135	RRM.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleolus	DNA binding|nucleotide binding|protein binding|RNA binding|transcription coactivator activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|urinary_tract(1)	11						TGCCCGCAGGCGCAGCCCCTT	0.577000													29	43					0	0	1	0	0
AHR	196	broad.mit.edu	37	7	17379517	17379517	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr7:17379517G>A	ENST00000242057.4	+	10	2711	c.2068G>A	c.(2068-2070)Gaa>Aaa	p.E690K		NM_001621.4	NP_001612.1	P35869	AHR_HUMAN	aryl hydrocarbon receptor	690					apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(11)|ovary(1)|pancreas(1)|urinary_tract(3)	33	Lung NSC(10;0.0392)|all_lung(11;0.0754)					CTACAAATCTGAAATGGATTC	0.403000													60	104					0	0	1	0	0
WDR64	128025	broad.mit.edu	37	1	241904945	241904945	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:241904945C>G	ENST00000366552.2	+	11	1626	c.1419C>G	c.(1417-1419)atC>atG	p.I473M	WDR64_ENST00000437684.2_Missense_Mutation_p.I473M	NM_144625.4	NP_653226.4	B1ANS9	WDR64_HUMAN	WD repeat domain 64	473										breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(17)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			TACTCACTATCTGCTCTGAAT	0.323000													24	42					0	0	1	0	0
HIP1R	9026	broad.mit.edu	37	12	123338615	123338615	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr12:123338615C>T	ENST00000253083.4	+	8	728	c.603C>T	c.(601-603)atC>atT	p.I201I		NM_003959.1	NP_003950.1	O75146	HIP1R_HUMAN	huntingtin interacting protein 1 related	201					receptor-mediated endocytosis	clathrin coated vesicle membrane|coated pit|perinuclear region of cytoplasm	actin binding|phosphatidylinositol binding			breast(1)|endometrium(5)|kidney(6)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	26	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;4.6e-05)|Epithelial(86;0.000119)|BRCA - Breast invasive adenocarcinoma(302;0.2)		ACACGGCCATCGCCGTATCCC	0.602000													77	87					0	0	1	0	0
AHR	196	broad.mit.edu	37	7	17378976	17378976	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr7:17378976G>A	ENST00000242057.4	+	10	2170	c.1527G>A	c.(1525-1527)ctG>ctA	p.L509L	AHR_ENST00000492120.1_3'UTR	NM_001621.4	NP_001612.1	P35869	AHR_HUMAN	aryl hydrocarbon receptor	509					apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(11)|ovary(1)|pancreas(1)|urinary_tract(3)	33	Lung NSC(10;0.0392)|all_lung(11;0.0754)					ATACTATCCTGAAACATGAGC	0.398000													46	106					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135430771	135430771	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chrX:135430771G>A	ENST00000394143.1	+	6	5197	c.4906G>A	c.(4906-4908)Gca>Aca	p.A1636T	GPR112_ENST00000287534.4_Missense_Mutation_p.A1573T|GPR112_ENST00000370652.1_Missense_Mutation_p.A1636T|GPR112_ENST00000412101.1_Missense_Mutation_p.A1431T|GPR112_ENST00000394141.1_Missense_Mutation_p.A1431T	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	1636					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					AATGATAGAGGCACCTTCCAG	0.448000													130	38					0	0	1	0	0
QPCTL	54814	broad.mit.edu	37	19	46202132	46202132	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:46202132G>A	ENST00000012049.5	+	5	1081	c.860G>A	c.(859-861)cGc>cAc	p.R287H	QPCTL_ENST00000366382.4_Missense_Mutation_p.R193H	NM_017659.3	NP_060129.2	Q9NXS2	QPCTL_HUMAN	glutaminyl-peptide cyclotransferase-like	287					peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase|proteolysis	Golgi membrane|integral to membrane	acyltransferase activity|glutaminyl-peptide cyclotransferase activity|peptidase activity|protein binding|zinc ion binding			breast(1)|cervix(2)|endometrium(1)|lung(5)|skin(1)|stomach(1)	11		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0059)|GBM - Glioblastoma multiforme(486;0.0882)|Epithelial(262;0.208)		CGCACGGTCCGCTGGTTCCAT	0.612000													82	124					0	0	1	0	0
ZNHIT1	10467	broad.mit.edu	37	7	100866959	100866959	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr7:100866959G>C	ENST00000305105.2	+	4	807	c.279G>C	c.(277-279)ttG>ttC	p.L93F	ZNHIT1_ENST00000492315.1_3'UTR	NM_006349.2	NP_006340.1	O43257	ZNHI1_HUMAN	zinc finger, HIT-type containing 1	93							metal ion binding|protein binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(2)	11	Lung NSC(181;0.168)|all_lung(186;0.215)					TGCAGAACTTGAGTGTGGCCG	0.677000													44	92					0	0	1	0	0
SLC4A11	83959	broad.mit.edu	37	20	3214842	3214842	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr20:3214842C>T	ENST00000380059.3	-	5	640	c.539G>A	c.(538-540)cGg>cAg	p.R180Q	SLC4A11_ENST00000539553.2_Missense_Mutation_p.R137Q|SLC4A11_ENST00000380056.3_Missense_Mutation_p.R153Q	NM_001174090.1	NP_001167561.1	Q8NBS3	S4A11_HUMAN	solute carrier family 4, sodium borate transporter, member 11	153					cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(1)|lung(16)|ovary(2)|prostate(4)|soft_tissue(1)|urinary_tract(1)	40						AAGCATGGTCCGCAGCACGTT	0.627000													47	91					0	0	1	0	0
KIAA1432	57589	broad.mit.edu	37	9	5742887	5742887	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr9:5742887G>T	ENST00000414202.2	+	9	1111	c.920G>T	c.(919-921)gGa>gTa	p.G307V	KIAA1432_ENST00000418622.3_Missense_Mutation_p.G228V|KIAA1432_ENST00000381532.2_Missense_Mutation_p.G228V|KIAA1432_ENST00000251879.6_Missense_Mutation_p.G307V|KIAA1432_ENST00000449720.2_Missense_Mutation_p.G228V	NM_001206557.1|NM_020829.3	NP_001193486.1|NP_065880.2	Q4ADV7	RIC1_HUMAN	KIAA1432	307						integral to membrane				breast(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(6)|lung(23)|prostate(1)|upper_aerodigestive_tract(1)	45		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		AATAAAACAGGAGCTGTTAAA	0.338000													38	70					1.96642e-18	2.05442e-18	1	1	0
TRAV2	28691	broad.mit.edu	37	14	22180598	22180598	+	RNA	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr14:22180598C>T	ENST00000390424.2	+	0	55																											TAGGGCTTCTCCTCAACTCTC	0.413000													47	126					0	0	1	0	0
DNAJC13	23317	broad.mit.edu	37	3	132226123	132226123	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:132226123G>A	ENST00000260818.6	+	43	5289	c.5041G>A	c.(5041-5043)Gat>Aat	p.D1681N		NM_015268.3	NP_056083.3	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	1681							heat shock protein binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|urinary_tract(1)	34						TGTCTACAGTGATCATGCCAA	0.333000													49	106					0	0	1	0	0
TBC1D12	23232	broad.mit.edu	37	10	96162370	96162370	+	Translation_Start_Site	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr10:96162370G>A	ENST00000225235.4	+	0	110					NM_015188.1	NP_056003.1	O60347	TBC12_HUMAN	TBC1 domain family, member 12							intracellular	Rab GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|upper_aerodigestive_tract(2)	20		Colorectal(252;0.0429)				CCCACCCCCAGATGGTGGGTC	0.697000													17	17					0	0	1	0	0
ETV3L	440695	broad.mit.edu	37	1	157062784	157062784	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:157062784G>C	ENST00000454449.2	-	5	1027	c.743C>G	c.(742-744)tCg>tGg	p.S248W		NM_001004341.2	NP_001004341.1	Q6ZN32	ETV3L_HUMAN	ets variant 3-like	248	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	24	Hepatocellular(266;0.158)	Prostate(1639;0.184)				GAAGGGCCCCGAGAGACAGGT	0.652000													7	28					0	0	1	0	0
ACOX2	8309	broad.mit.edu	37	3	58519238	58519238	+	Missense_Mutation	SNP	C	C	T	rs145801962		TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:58519238C>T	ENST00000302819.5	-	5	808	c.517G>A	c.(517-519)Gca>Aca	p.A173T	ACOX2_ENST00000459701.2_Missense_Mutation_p.A173T	NM_003500.3	NP_003491.1	Q99424	ACOX2_HUMAN	acyl-CoA oxidase 2, branched chain	173					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity|acyl-CoA dehydrogenase activity|pristanoyl-CoA oxidase activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)|skin(3)|urinary_tract(1)	25				BRCA - Breast invasive adenocarcinoma(55;0.000194)|Kidney(10;0.00255)|KIRC - Kidney renal clear cell carcinoma(10;0.00268)|OV - Ovarian serous cystadenocarcinoma(275;0.156)		TGGGTGGCTGCGTCATAGGTG	0.542000											OREG0015638	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	142					0	0	1	0	0
DISP2	85455	broad.mit.edu	37	15	40660785	40660785	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr15:40660785C>G	ENST00000267889.3	+	8	2559	c.2472C>G	c.(2470-2472)ttC>ttG	p.F824L		NM_033510.1	NP_277045.1	A7MBM2	DISP2_HUMAN	dispatched homolog 2 (Drosophila)	824					smoothened signaling pathway	integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(12)|ovary(4)	30		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		ATCAGAGCTTCTTCGACACCC	0.687000													15	40					0	0	1	0	0
MAP7	9053	broad.mit.edu	37	6	136710649	136710649	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr6:136710649C>G	ENST00000354570.3	-	4	661	c.251G>C	c.(250-252)aGa>aCa	p.R84T	MAP7_ENST00000438100.2_Missense_Mutation_p.R106T|MAP7_ENST00000544465.1_Missense_Mutation_p.R69T|MAP7_ENST00000454590.1_Missense_Mutation_p.R106T|MAP7_ENST00000432797.2_5'UTR	NM_001198616.1|NM_001198617.1|NM_001198619.1|NM_003980.4	NP_001185545.1|NP_001185546.1|NP_001185548.1|NP_003971.1	Q14244	MAP7_HUMAN	microtubule-associated protein 7	84					establishment or maintenance of cell polarity|microtubule cytoskeleton organization|protein localization in plasma membrane|response to osmotic stress	basolateral plasma membrane|microtubule|microtubule associated complex|nucleus|perinuclear region of cytoplasm	receptor binding|structural molecule activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(11)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00199)|OV - Ovarian serous cystadenocarcinoma(155;0.00643)		CACTATTTCTCTTGCAGCTTT	0.448000													52	105					0	0	1	0	0
METTL3	56339	broad.mit.edu	37	14	21967206	21967206	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr14:21967206C>G	ENST00000298717.4	-	10	1745	c.1594G>C	c.(1594-1596)Gag>Cag	p.E532Q	TOX4_ENST00000262709.3_3'UTR|TOX4_ENST00000405508.1_3'UTR	NM_019852.3	NP_062826.2	Q86U44	MTA70_HUMAN	methyltransferase like 3	532					gene expression	nuclear speck	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity|RNA binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	20	all_cancers(95;0.000628)		Epithelial(56;6.61e-06)	GBM - Glioblastoma multiforme(265;0.0146)		CCAAATAACTCAATCTTGCGA	0.423000													24	76					0	0	1	0	0
IL6	3569	broad.mit.edu	37	7	22769210	22769210	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr7:22769210G>C	ENST00000404625.1	+	5	861	c.402G>C	c.(400-402)gaG>gaC	p.E134D	IL6_ENST00000420258.2_Missense_Mutation_p.E188D|IL6_ENST00000406575.1_Missense_Mutation_p.E134D|IL6_ENST00000258743.5_Missense_Mutation_p.E134D|IL6_ENST00000401630.3_Missense_Mutation_p.E111D|IL6_ENST00000401651.1_Missense_Mutation_p.E58D|IL6_ENST00000407492.1_Missense_Mutation_p.E58D			P05231	IL6_HUMAN	interleukin 6 (interferon, beta 2)	134					acute-phase response|cellular response to hydrogen peroxide|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|defense response to virus|endocrine pancreas development|glucagon secretion|hepatic immune response|interleukin-6-mediated signaling pathway|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of chemokine biosynthetic process|negative regulation of collagen biosynthetic process|negative regulation of fat cell differentiation|negative regulation of lipid storage|neuron projection development|neutrophil apoptosis|platelet activation|positive regulation of acute inflammatory response|positive regulation of anti-apoptosis|positive regulation of B cell activation|positive regulation of chemokine production|positive regulation of immunoglobulin secretion|positive regulation of interleukin-6 production|positive regulation of osteoblast differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of smooth muscle cell proliferation|positive regulation of T cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of translation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of vascular endothelial growth factor production|response to glucocorticoid stimulus|response to peptidoglycan	extracellular space|interleukin-6 receptor complex	cytokine activity|growth factor activity|interleukin-6 receptor binding			breast(1)|endometrium(2)|large_intestine(4)|lung(1)	8					Arsenic trioxide(DB01169)|Bicalutamide(DB01128)|Ginseng(DB01404)|Simvastatin(DB00641)	ACAGATTTGAGAGTAGTGAGG	0.463000													60	72					0	0	1	0	0
METTL16	79066	broad.mit.edu	37	17	2310511	2310511	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr17:2310511G>A	ENST00000609667.1	-	3	340	c.261C>T	c.(259-261)atC>atT	p.I87I																								GACGGATGACGATGTCAGGGA	0.522000													18	24					0	0	1	0	0
MAPT	4137	broad.mit.edu	37	17	44073864	44073864	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr17:44073864C>A	ENST00000344290.5	+	11	1983	c.1661C>A	c.(1660-1662)cCc>cAc	p.P554H	MAPT_ENST00000446361.3_Missense_Mutation_p.P161H|MAPT_ENST00000262410.5_Missense_Mutation_p.P536H|MAPT_ENST00000535772.1_Missense_Mutation_p.P219H|MAPT_ENST00000334239.8_Missense_Mutation_p.P161H|MAPT_ENST00000576518.1_Missense_Mutation_p.P150H|MAPT_ENST00000351559.5_Missense_Mutation_p.P219H|MAPT_ENST00000431008.3_Missense_Mutation_p.P219H|MAPT_ENST00000571987.1_Missense_Mutation_p.P536H|MAPT_ENST00000420682.2_Missense_Mutation_p.P190H|MAPT_ENST00000570299.1_3'UTR|MAPT_ENST00000340799.5_Missense_Mutation_p.P190H|MAPT_ENST00000415613.2_Missense_Mutation_p.P554H|MAPT_ENST00000347967.5_Missense_Mutation_p.P125H|MAPT_ENST00000574436.1_Missense_Mutation_p.P219H	NM_001123066.3	NP_001116538.2	P10636	TAU_HUMAN	microtubule-associated protein tau	536					cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			breast(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	38		Melanoma(429;0.216)				CCAACCCCACCCACCCGGGAG	0.692000													22	31					7.07758e-08	7.15152e-08	1	1	0
ZNF423	23090	broad.mit.edu	37	16	49670625	49670625	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr16:49670625C>T	ENST00000561648.1	-	4	2491	c.2438G>A	c.(2437-2439)aGc>aAc	p.S813N	ZNF423_ENST00000262383.2_Missense_Mutation_p.S813N|ZNF423_ENST00000562520.1_Missense_Mutation_p.S753N|ZNF423_ENST00000535559.1_Missense_Mutation_p.S696N|ZNF423_ENST00000562871.1_Missense_Mutation_p.S753N|ZNF423_ENST00000567169.1_Missense_Mutation_p.S696N|ZNF423_ENST00000563137.2_Missense_Mutation_p.S753N	NM_001271620.1	NP_001258549.1	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	813					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				GAAGGCCTTGCTGCAGAACTT	0.567000													59	37					0	0	1	0	0
PUM1	9698	broad.mit.edu	37	1	31465320	31465320	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:31465320G>A	ENST00000373747.3	-	7	1174	c.1075C>T	c.(1075-1077)Cag>Tag	p.Q359*	PUM1_ENST00000423018.2_Nonsense_Mutation_p.Q263*|PUM1_ENST00000424085.2_Intron|PUM1_ENST00000373741.4_Nonsense_Mutation_p.Q395*|PUM1_ENST00000373742.2_Nonsense_Mutation_p.Q299*|PUM1_ENST00000426105.2_Nonsense_Mutation_p.Q359*|PUM1_ENST00000257075.5_Nonsense_Mutation_p.Q359*|PUM1_ENST00000440538.2_Nonsense_Mutation_p.Q359*	NM_001020658.1	NP_001018494.1	Q14671	PUM1_HUMAN	pumilio RNA-binding family member 1	359					cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(17)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		TAATCAAACTGAAGAGGCTCC	0.517000													55	157					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414340	20414340	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr9:20414340G>A	ENST00000380338.4	-	5	790	c.504C>T	c.(502-504)agC>agT	p.S168S	MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S165S	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	168	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S168S(5)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.537000			T	MLL	ALL								8	161					0	0	1	0	0
ADAM21	8747	broad.mit.edu	37	14	70925822	70925822	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr14:70925822C>T	ENST00000603540.1	+	2	1864	c.1606C>T	c.(1606-1608)Cag>Tag	p.Q536*	ADAM21_ENST00000267499.3_Nonsense_Mutation_p.Q536*|RP11-486O13.4_ENST00000556646.1_lincRNA	NM_003813.3	NP_003804.2	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21	536	Cys-rich.				proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	31				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		AATCAATTCTCAGGGAAACCG	0.378000													20	26					0	0	1	0	0
ARMC3	219681	broad.mit.edu	37	10	23257415	23257415	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr10:23257415G>C	ENST00000298032.5	+	8	997	c.913G>C	c.(913-915)Gat>Cat	p.D305H	ARMC3_ENST00000409049.3_Missense_Mutation_p.D305H|ARMC3_ENST00000409983.3_Missense_Mutation_p.D305H|ARMC3_ENST00000376528.4_Missense_Mutation_p.D42H	NM_173081.3	NP_775104.2	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	305							binding			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(24)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						AGCAGCTTATGATCGTATGTC	0.413000													32	66					0	0	1	0	0
ANKIB1	54467	broad.mit.edu	37	7	91972508	91972508	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr7:91972508G>A	ENST00000265742.3	+	6	1334	c.958G>A	c.(958-960)Gaa>Aaa	p.E320K		NM_019004.1	NP_061877.1	Q9P2G1	AKIB1_HUMAN	ankyrin repeat and IBR domain containing 1	320							protein binding|zinc ion binding			cervix(1)|endometrium(7)|kidney(3)|large_intestine(10)|lung(19)|skin(1)	41	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			CTCCCCAGATGAAATCAGCTT	0.443000													20	43					0	0	1	0	0
ACRC	93953	broad.mit.edu	37	X	70823811	70823811	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chrX:70823811C>G	ENST00000373695.1	+	7	1221	c.684C>G	c.(682-684)agC>agG	p.S228R	ACRC_ENST00000373696.3_Missense_Mutation_p.S228R			Q96QF7	ACRC_HUMAN	acidic repeat containing	228	Asp/Ser-rich.					nucleus				autonomic_ganglia(1)|breast(1)|endometrium(15)|kidney(4)|large_intestine(4)|lung(20)|ovary(5)|prostate(1)|skin(2)|stomach(1)	54	Renal(35;0.156)					CCGACGACAGCAGTGATGATT	0.512000													6	421					0	0	1	0	0
FSD2	123722	broad.mit.edu	37	15	83438620	83438620	+	Silent	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr15:83438620G>C	ENST00000334574.8	-	8	1465	c.1284C>G	c.(1282-1284)gtC>gtG	p.V428V	FSD2_ENST00000541889.1_Intron			A1L4K1	FSD2_HUMAN	fibronectin type III and SPRY domain containing 2	428	Fibronectin type-III 1.									breast(2)|central_nervous_system(1)|large_intestine(5)|lung(10)	18						ATGTTTCTTTGACAGTCACTG	0.453000													23	55					0	0	1	0	0
FOXN3	1112	broad.mit.edu	37	14	89656743	89656743	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr14:89656743C>T	ENST00000345097.4	-	5	912	c.796G>A	c.(796-798)Gag>Aag	p.E266K	FOXN3_ENST00000261302.5_Missense_Mutation_p.E266K|FOXN3_ENST00000557258.1_Intron|FOXN3_ENST00000555353.1_Intron	NM_001085471.1	NP_001078940.1	O00409	FOXN3_HUMAN	forkhead box N3	266					DNA damage checkpoint|embryo development|G2 phase of mitotic cell cycle|negative regulation of transcription, DNA-dependent|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein C-terminus binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(4)|large_intestine(4)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						GCTTGTATCTCAGGGGGAGTA	0.403000													21	51					0	0	1	0	0
POLI	11201	broad.mit.edu	37	18	51820801	51820801	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr18:51820801G>T	ENST00000579534.1	+	10	2330	c.2187G>T	c.(2185-2187)aaG>aaT	p.K729N	POLI_ENST00000217800.5_Missense_Mutation_p.K603N|POLI_ENST00000579434.1_Missense_Mutation_p.K626N|POLI_ENST00000406285.3_Missense_Mutation_p.K650N	NM_007195.2	NP_009126.2	Q9UNA4	POLI_HUMAN	polymerase (DNA directed) iota	729					DNA repair|DNA replication	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(5)|ovary(3)|urinary_tract(1)	26				Colorectal(16;0.0234)|READ - Rectum adenocarcinoma(59;0.197)		CAGAGTGGAAGAGAGCAGGAT	0.378000								DNA polymerases (catalytic subunits)					30	39					1.39806e-14	1.44061e-14	1	1	0
MAPK10	5602	broad.mit.edu	37	4	87028487	87028487	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr4:87028487G>A	ENST00000395169.3	-	5	861	c.141C>T	c.(139-141)gtC>gtT	p.V47V	MAPK10_ENST00000395160.3_5'UTR|MAPK10_ENST00000395166.1_Silent_p.V47V|MAPK10_ENST00000449047.2_5'UTR|MAPK10_ENST00000395161.2_Silent_p.V85V|MAPK10_ENST00000359221.3_Silent_p.V85V|MAPK10_ENST00000513839.1_5'UTR|MAPK10_ENST00000361569.2_Silent_p.V85V	NM_138980.2|NM_138982.2	NP_620446.1|NP_620448.1	P53779	MK10_HUMAN	mitogen-activated protein kinase 10	85					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|MAP kinase kinase activity|protein binding			breast(1)|central_nervous_system(1)|stomach(1)	3		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.243)		OV - Ovarian serous cystadenocarcinoma(123;0.002)		TTCTGTCAAGGACAGCATCAT	0.453000													29	64					0	0	1	0	0
SOD3	6649	broad.mit.edu	37	4	24801411	24801411	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr4:24801411C>T	ENST00000382120.3	+	2	473	c.268C>T	c.(268-270)Cgc>Tgc	p.R90C		NM_003102.2	NP_003093.2	P08294	SODE_HUMAN	superoxide dismutase 3, extracellular	90					removal of superoxide radicals	extracellular space|nucleus|soluble fraction	copper ion binding|heparin binding|protein binding|superoxide dismutase activity|zinc ion binding			prostate(1)|urinary_tract(1)	2		Breast(46;0.0503)				GCTTGCGCCCCGCGCCAAGCT	0.741000													5	7					0	0	1	0	0
SLC2A2	6514	broad.mit.edu	37	3	170723895	170723895	+	Splice_Site	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:170723895C>G	ENST00000314251.3	-	6	692		c.e6-1		SLC2A2_ENST00000382808.4_Splice_Site	NM_000340.1	NP_000331.1	P11168	GTR2_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 2						carbohydrate metabolic process|cellular lipid metabolic process|endocrine pancreas development|energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane|membrane fraction	D-glucose transmembrane transporter activity			central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(22;1.41e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;1.1e-14)|Lung(28;2.99e-14)			GACCAATAATCTGAAAATGCA	0.383000													16	46					0	0	1	0	0
ZNF496	84838	broad.mit.edu	37	1	247471861	247471861	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:247471861C>G	ENST00000294753.4	-	8	1386	c.922G>C	c.(922-924)Gaa>Caa	p.E308Q	ZNF496_ENST00000366498.2_Missense_Mutation_p.E344Q|ZNF496_ENST00000462139.1_5'UTR	NM_032752.1	NP_116141.1	Q96IT1	ZN496_HUMAN	zinc finger protein 496	308					positive regulation of transcription, DNA-dependent|viral reproduction		DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	36	all_cancers(71;0.000136)|all_epithelial(71;2.62e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)		OV - Ovarian serous cystadenocarcinoma(106;0.00703)			CTTCTTTCTTCTACCTGGAAT	0.522000													30	118					0	0	1	0	0
CAPS2	84698	broad.mit.edu	37	12	75693620	75693620	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr12:75693620G>A	ENST00000393284.3	-	9	813	c.212C>T	c.(211-213)tCa>tTa	p.S71L	CAPS2_ENST00000409799.1_Missense_Mutation_p.S253L|CAPS2_ENST00000409004.1_5'UTR|CAPS2_ENST00000409445.3_Missense_Mutation_p.S303L|CAPS2_ENST00000442339.2_Intron			Q9BXY5	CAYP2_HUMAN	calcyphosine 2	303							calcium ion binding			endometrium(2)|large_intestine(1)|lung(4)|ovary(2)|skin(1)	10						CAATTACCGTGATACGATCCT	0.264000													45	140					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79028228	79028228	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr5:79028228C>T	ENST00000446378.2	+	2	3671	c.3640C>T	c.(3640-3642)Caa>Taa	p.Q1214*		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1214						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		GCCTGATTCTCAAGAAGCTAC	0.428000													13	24					0	0	1	0	0
FAM208B	54906	broad.mit.edu	37	10	5798685	5798685	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr10:5798685C>T	ENST00000328090.5	+	16	7341	c.6716C>T	c.(6715-6717)tCa>tTa	p.S2239L		NM_017782.4	NP_060252	Q5VWN6	CJ018_HUMAN	family with sequence similarity 208, member B	2239								p.S2239L(1)									GAAGATATATCATCACATTTG	0.383000													34	64					0	0	1	0	0
ELP4	26610	broad.mit.edu	37	11	31671767	31671767	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr11:31671767G>C	ENST00000395934.2	+	9	1148	c.1141G>C	c.(1141-1143)Gag>Cag	p.E381Q	ELP4_ENST00000350638.5_Missense_Mutation_p.E381Q|ELP4_ENST00000379163.5_Missense_Mutation_p.E382Q|Z83001.1_ENST00000429821.1_RNA			Q96EB1	ELP4_HUMAN	elongator acetyltransferase complex subunit 4	381					histone acetylation|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|Elongator holoenzyme complex|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(3)	20	Lung SC(675;0.225)					ATTCACCATTGAGGTAAGAGA	0.259000													30	45					0	0	1	0	0
PPHLN1	51535	broad.mit.edu	37	12	42835288	42835288	+	Missense_Mutation	SNP	C	C	G	rs35700831		TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr12:42835288C>G	ENST00000549190.1	+	10	1316	c.1135C>G	c.(1135-1137)Caa>Gaa	p.Q379E	PPHLN1_ENST00000317560.9_Intron|PPHLN1_ENST00000395568.2_Intron|PPHLN1_ENST00000395580.3_Missense_Mutation_p.Q368E|PPHLN1_ENST00000449194.2_Missense_Mutation_p.Q342E|PPHLN1_ENST00000256678.8_Intron|PPHLN1_ENST00000552761.1_Missense_Mutation_p.Q313E|PPHLN1_ENST00000432191.2_Intron|PPHLN1_ENST00000358314.7_Missense_Mutation_p.Q361E|PPHLN1_ENST00000337898.6_Intron			Q8NEY8	PPHLN_HUMAN	periphilin 1	0					keratinization	cytoplasm|nucleus				breast(5)|kidney(1)|large_intestine(4)|lung(2)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	16	all_cancers(12;0.00049)|Breast(8;0.165)	Lung NSC(34;0.123)		GBM - Glioblastoma multiforme(48;0.0875)		TACTTCCACTCAAGATTTTGG	0.323000													31	44					0	0	1	0	0
KCNS1	3787	broad.mit.edu	37	20	43726795	43726795	+	Silent	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr20:43726795G>C	ENST00000306117.1	-	4	1014	c.618C>G	c.(616-618)ctC>ctG	p.L206L	KCNS1_ENST00000537075.1_Silent_p.L206L	NM_002251.3	NP_002242.2	Q96KK3	KCNS1_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1	206						voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity|protein binding			endometrium(1)|lung(3)|ovary(1)|stomach(1)	6		Myeloproliferative disorder(115;0.0122)				TGGTCAGCCAGAGGCGGCGGC	0.701000													4	12					0	0	1	0	0
LTA	4049	broad.mit.edu	37	6	31541102	31541102	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr6:31541102G>A	ENST00000454783.1	+	4	508	c.250G>A	c.(250-252)Gac>Aac	p.D84N	LTA_ENST00000418386.2_Missense_Mutation_p.D84N	NM_001159740.2	NP_001153212.1	P01374	TNFB_HUMAN	lymphotoxin alpha	84					cell-cell signaling|induction of apoptosis|signal transduction	extracellular space|membrane	cytokine activity|tumor necrosis factor receptor binding			endometrium(2)|kidney(2)|lung(4)|upper_aerodigestive_tract(1)	9					Etanercept(DB00005)	AGCAAACACGGACCGTGCCTT	0.567000													33	60					0	0	1	0	0
CDH7	1005	broad.mit.edu	37	18	63547879	63547879	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr18:63547879G>C	ENST00000397968.2	+	12	2533	c.2107G>C	c.(2107-2109)Gat>Cat	p.D703H	CDH7_ENST00000323011.3_Missense_Mutation_p.D703H	NM_004361.2	NP_004352.2	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2	703					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(43)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	80		Esophageal squamous(42;0.129)				AAGCATCCCAGATAATGTCAT	0.443000													80	134					0	0	1	0	0
TPH1	7166	broad.mit.edu	37	11	18051117	18051117	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr11:18051117C>T	ENST00000250018.2	-	4	974	c.412G>A	c.(412-414)Gac>Aac	p.D138N	TPH1_ENST00000341556.2_Missense_Mutation_p.D138N	NM_004179.2	NP_004170.1	P17752	TPH1_HUMAN	tryptophan hydroxylase 1	138					aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(14)|prostate(1)|stomach(1)	25					L-Tryptophan(DB00150)|Tetrahydrobiopterin(DB00360)	TAGACATTGTCTTTGAAGCCC	0.269000													110	200					0	0	1	0	0
PPP2R5D	5528	broad.mit.edu	37	6	42975000	42975000	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr6:42975000G>A	ENST00000485511.1	+	5	768	c.589G>A	c.(589-591)Gag>Aag	p.E197K	PPP2R5D_ENST00000394110.3_Missense_Mutation_p.E165K|PPP2R5D_ENST00000472118.1_Missense_Mutation_p.E189K|PPP2R5D_ENST00000461010.1_Missense_Mutation_p.E91K	NM_001270476.1|NM_006245.3	NP_001257405.1|NP_006236.1	Q14738	2A5D_HUMAN	protein phosphatase 2, regulatory subunit B', delta	197					nervous system development|signal transduction	cytoplasm|nucleus|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	25			Colorectal(64;0.00237)|all cancers(41;0.00411)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0664)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			GTTTGACCCAGAGGAAGATGA	0.612000													72	146					0	0	1	0	0
WDR49	151790	broad.mit.edu	37	3	167293719	167293719	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:167293719G>C	ENST00000308378.3	-	4	778	c.473C>G	c.(472-474)tCt>tGt	p.S158C	WDR49_ENST00000453925.2_Missense_Mutation_p.S211C|WDR49_ENST00000479765.1_Missense_Mutation_p.S499C	NM_178824.3	NP_849146.1	Q8IV35	WDR49_HUMAN	WD repeat domain 49	158										breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	50						CTTCAAGATAGAATTGTAAAG	0.373000													66	112					0	0	1	0	0
HUWE1	10075	broad.mit.edu	37	X	53564591	53564591	+	Silent	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chrX:53564591G>C	ENST00000342160.3	-	77	12520	c.12063C>G	c.(12061-12063)gtC>gtG	p.V4021V	HUWE1_ENST00000262854.6_Silent_p.V4021V			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	4021					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						GGTCACGACGGACATGCACAG	0.488000													26	9					0	0	1	0	0
ZNF695	57116	broad.mit.edu	37	1	247150744	247150744	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:247150744C>A	ENST00000339986.7	-	4	1220	c.1073G>T	c.(1072-1074)gGa>gTa	p.G358V	ZNF695_ENST00000487338.2_Intron|ZNF695_ENST00000498046.2_Intron	NM_020394.4	NP_065127	Q8IW36	ZN695_HUMAN	zinc finger protein 695	358					regulation of transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			endometrium(1)|large_intestine(1)|lung(9)|prostate(1)|urinary_tract(1)	13	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			AAAGGCTTTTCCACATTCTTC	0.388000													13	45					5.50884e-06	5.54158e-06	1	1	0
MBD1	4152	broad.mit.edu	37	18	47799322	47799322	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr18:47799322C>T	ENST00000591416.1	-	14	2019	c.1588G>A	c.(1588-1590)Gta>Ata	p.V530I	MBD1_ENST00000457839.2_Missense_Mutation_p.V555I|MBD1_ENST00000353909.3_Missense_Mutation_p.V481I|MBD1_ENST00000269471.5_Missense_Mutation_p.V461I|MBD1_ENST00000585595.1_Missense_Mutation_p.V555I|MBD1_ENST00000347968.3_Missense_Mutation_p.V474I|MBD1_ENST00000398488.1_Missense_Mutation_p.V428I|MBD1_ENST00000591535.1_Missense_Mutation_p.V461I|MBD1_ENST00000398495.2_Missense_Mutation_p.V499I|MBD1_ENST00000424334.2_Missense_Mutation_p.V581I|MBD1_ENST00000588937.1_Missense_Mutation_p.V461I|MBD1_ENST00000339998.6_Missense_Mutation_p.V484I|MBD1_ENST00000436910.1_Missense_Mutation_p.V461I|MBD1_ENST00000398493.1_Missense_Mutation_p.V474I|MBD1_ENST00000587605.1_Missense_Mutation_p.V428I|MBD1_ENST00000590208.1_Missense_Mutation_p.V530I|MBD1_ENST00000349085.2_Missense_Mutation_p.V428I|MBD1_ENST00000585672.1_Missense_Mutation_p.V480I|MBD1_ENST00000382948.5_Missense_Mutation_p.V530I|MBD1_ENST00000269468.5_Missense_Mutation_p.V530I			Q9UIS9	MBD1_HUMAN	methyl-CpG binding domain protein 1	530	TRD.				negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|nuclear speck	methyl-CpG binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36						CCTGGGTCTACTGCCTGGGAG	0.532000													48	65					0	0	1	0	0
NDUFAF5	79133	broad.mit.edu	37	20	13765791	13765791	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr20:13765791G>A	ENST00000378106.5	+	1	196	c.77G>A	c.(76-78)cGt>cAt	p.R26H	NDUFAF5_ENST00000463598.1_Missense_Mutation_p.R26H|NDUFAF5_ENST00000475968.1_3'UTR	NM_024120.4	NP_077025.2	Q5TEU4	CT007_HUMAN	NADH dehydrogenase (ubiquinone) complex I, assembly factor 5	26					mitochondrial respiratory chain complex I assembly	extrinsic to mitochondrial inner membrane	methyltransferase activity										AATCTTGGCCGTAGGGAAGTC	0.612000													9	23					0	0	1	0	0
MAPT	4137	broad.mit.edu	37	17	44049256	44049256	+	Silent	SNP	A	A	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr17:44049256A>C	ENST00000344290.5	+	3	487	c.165A>C	c.(163-165)ggA>ggC	p.G55G	MAPT_ENST00000446361.3_Intron|MAPT_ENST00000262410.5_Silent_p.G55G|MAPT_ENST00000535772.1_Silent_p.G55G|MAPT_ENST00000334239.8_Intron|MAPT_ENST00000351559.5_Silent_p.G55G|MAPT_ENST00000431008.3_Silent_p.G55G|MAPT_ENST00000571987.1_Silent_p.G55G|MAPT_ENST00000420682.2_Silent_p.G55G|MAPT_ENST00000570299.1_Intron|MAPT_ENST00000340799.5_Silent_p.G55G|MAPT_ENST00000415613.2_Silent_p.G55G|MAPT_ENST00000347967.5_5'UTR|MAPT_ENST00000574436.1_Silent_p.G55G	NM_001123066.3	NP_001116538.2	P10636	TAU_HUMAN	microtubule-associated protein tau	55					cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			breast(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	38		Melanoma(429;0.216)				CTGAGGACGGATCTGAGGAAC	0.612000													13	37					0	0	1	0	0
CKB	1152	broad.mit.edu	37	14	103986600	103986600	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr14:103986600G>A	ENST00000348956.2	-	7	1183	c.826C>T	c.(826-828)Cac>Tac	p.H276Y		NM_001823.4	NP_001814.2	P12277	KCRB_HUMAN	creatine kinase, brain	276	Phosphagen kinase C-terminal.				creatine metabolic process	cytosol	ATP binding|creatine kinase activity			lung(2)|prostate(1)	3		Melanoma(154;0.155)	Epithelial(46;0.14)		Creatine(DB00148)	TAGCCCAGGTGAGGGTTCCAC	0.552000													24	39					0	0	1	0	0
FRMPD1	22844	broad.mit.edu	37	9	37745139	37745139	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr9:37745139C>T	ENST00000539465.1	+	16	3703	c.3110C>T	c.(3109-3111)tCt>tTt	p.S1037F	FRMPD1_ENST00000377765.3_Missense_Mutation_p.S1037F|RP11-613M10.9_ENST00000540557.1_Intron			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	1037						cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		AATAATGTCTCTCAAGGAGAC	0.498000													64	104					0	0	1	0	0
PPP2R3B	28227	broad.mit.edu	37	X	299415	299415	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chrX:299415C>A	ENST00000390665.3	-	12	1519	c.1501G>T	c.(1501-1503)Gac>Tac	p.D501Y		NM_013239.4	NP_037371.2	Q9Y5P8	P2R3B_HUMAN	protein phosphatase 2, regulatory subunit B'', beta	501					cell cycle arrest|protein dephosphorylation	nucleus|protein phosphatase type 2A complex	calcium ion binding|protein phosphatase type 2A regulator activity|protein serine/threonine phosphatase activity			endometrium(5)|lung(5)|skin(1)	11		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TTCTCCCAGTCCGAGAGCTCG	0.711000													30	9					4.3949e-29	4.66355e-29	1	1	0
WBP2NL	164684	broad.mit.edu	37	22	42422822	42422822	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr22:42422822C>T	ENST00000328823.9	+	6	598	c.567C>T	c.(565-567)taC>taT	p.Y189Y	WBP2NL_ENST00000543212.1_Silent_p.Y115Y	NM_152613.2	NP_689826.2	Q6ICG8	WBP2L_HUMAN	WBP2 N-terminal like	189	10 X 7 AA tandem repeat of Y-G-X-P-P-X-G.|Gly-rich.				egg activation|male pronucleus assembly|meiosis	perinuclear theca	WW domain binding			breast(2)|large_intestine(3)|lung(5)|ovary(3)|prostate(1)	14						CTCCCGGATACGGAGCCCCAC	0.527000													6	216					0	0	1	0	0
PIWIL3	440822	broad.mit.edu	37	22	25150141	25150141	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr22:25150141G>C	ENST00000332271.5	-	8	1233	c.817C>G	c.(817-819)Caa>Gaa	p.Q273E	PIWIL3_ENST00000527701.1_Missense_Mutation_p.Q164E|PIWIL3_ENST00000532537.2_5'UTR|PIWIL3_ENST00000533313.1_Missense_Mutation_p.Q164E	NM_001008496.3|NM_001255975.1	NP_001008496.2|NP_001242904.1	Q7Z3Z3	PIWL3_HUMAN	piwi-like RNA-mediated gene silencing 3	273					cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(15)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						TTTTCGTATTGAAGAACAGAA	0.408000													41	38					0	0	1	0	0
SVIL	6840	broad.mit.edu	37	10	29821001	29821001	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr10:29821001C>G	ENST00000375398.2	-	11	2388	c.1939G>C	c.(1939-1941)Gaa>Caa	p.E647Q	SVIL_ENST00000375400.3_Intron|SVIL_ENST00000355867.4_Missense_Mutation_p.E647Q			O95425	SVIL_HUMAN	supervillin	647					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(24)|lung(35)|ovary(8)|prostate(2)|skin(4)|stomach(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	112		Breast(68;0.103)				TTTCTACTTTCACCAGGAGAA	0.512000													55	131					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48729225	48729225	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr15:48729225G>A	ENST00000316623.5	-	53	6884	c.6429C>T	c.(6427-6429)atC>atT	p.I2143I		NM_000138.4	NP_000129	P35555	FBN1_HUMAN	fibrillin 1	2143	EGF-like 36; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		CATCTGTATTGATGCACTGTC	0.368000													61	66					0	0	1	0	0
POTEG	404785	broad.mit.edu	37	14	19553588	19553588	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr14:19553588A>G	ENST00000409832.3	+	1	224	c.172A>G	c.(172-174)Agg>Ggg	p.R58G		NM_001005356.2	NP_001005356.1	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	58										cervix(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(31)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	47						GAAGACACTCAGGAGCAAGAT	0.617000													27	599					0	0	1	0	0
RAD21	5885	broad.mit.edu	37	8	117866528	117866528	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr8:117866528A>G	ENST00000297338.2	-	9	1404	c.1117T>C	c.(1117-1119)Ttt>Ctt	p.F373L		NM_006265.2	NP_006256.1	O60216	RAD21_HUMAN	RAD21 homolog (S. pombe)	373	Interaction with STAG1.|Interaction with WAPAL and PDS5B.				apoptosis|cell division|chromosome segregation|double-strand break repair|mitotic metaphase/anaphase transition|mitotic prometaphase|protein localization to chromatin|reciprocal meiotic recombination|regulation of transcription from RNA polymerase II promoter	chromosome, centromeric region|cohesin complex|nuclear chromosome|nucleoplasm	protein binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|skin(1)|stomach(1)	32	all_cancers(13;1.21e-21)|Lung NSC(37;0.000134)|Ovarian(258;0.0172)					GGTAAAGAAAACAGTTTTTCT	0.353000													46	83					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42041294	42041294	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:42041294C>G	ENST00000372584.1	-	4	6142	c.5128G>C	c.(5128-5130)Gag>Cag	p.E1710Q	HIVEP3_ENST00000247584.5_Missense_Mutation_p.E1710Q|HIVEP3_ENST00000372583.1_Missense_Mutation_p.E1710Q|HIVEP3_ENST00000429157.2_Missense_Mutation_p.E1710Q|HIVEP3_ENST00000460604.1_5'UTR	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	1710					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				CCTCTCCTCTCTTCTTCCTTC	0.552000													40	115					0	0	1	0	0
UHMK1	127933	broad.mit.edu	37	1	162467949	162467949	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:162467949C>T	ENST00000489294.1	+	1	317	c.159C>T	c.(157-159)ctC>ctT	p.L53L	UHMK1_ENST00000538489.1_Silent_p.L53L|UHMK1_ENST00000545294.1_Intron|UHMK1_ENST00000282169.8_3'UTR	NM_175866.4	NP_787062.1	Q8TAS1	UHMK1_HUMAN	U2AF homology motif (UHM) kinase 1	53	Protein kinase.				cell cycle arrest|neuron projection development|peptidyl-serine phosphorylation|positive regulation of translational initiation|protein autophosphorylation|regulation of protein export from nucleus	axon|dendrite cytoplasm|neuronal RNA granule|nucleus	protein binding|protein serine/threonine kinase activity|ribonucleoprotein binding|RNA binding			endometrium(1)|large_intestine(2)|lung(6)|prostate(2)	11	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)			CCGGCGCCCTCAAGCAGTTCT	0.687000													5	21					0	0	1	0	0
LRTM2	654429	broad.mit.edu	37	12	1943797	1943797	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr12:1943797G>T	ENST00000543818.1	+	5	1865	c.1023G>T	c.(1021-1023)aaG>aaT	p.K341N	CACNA2D4_ENST00000587995.1_Intron|CACNA2D4_ENST00000586184.1_Intron|CACNA2D4_ENST00000588077.1_Intron|CACNA2D4_ENST00000382722.5_Intron|LRTM2_ENST00000543730.1_3'UTR|LRTM2_ENST00000299194.1_Missense_Mutation_p.K341N|CACNA2D4_ENST00000585732.1_Intron|LRTM2_ENST00000535041.1_Missense_Mutation_p.K341N|CACNA2D4_ENST00000585708.1_Intron	NM_001039029.2|NM_001163925.1|NM_001163926.1	NP_001034118.1|NP_001157397.1|NP_001157398.1	Q8N967	LRTM2_HUMAN	leucine-rich repeats and transmembrane domains 2	341						integral to membrane				NS(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	20	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000834)			TCATGGCCAAGTACCACCGGG	0.637000													25	53					6.32553e-13	6.48846e-13	1	1	0
INPPL1	3636	broad.mit.edu	37	11	71946178	71946178	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr11:71946178G>C	ENST00000541756.1	+	22	2638	c.1708G>C	c.(1708-1710)Gat>Cat	p.D570H	INPPL1_ENST00000298229.2_Missense_Mutation_p.D812H|INPPL1_ENST00000538751.1_Missense_Mutation_p.D570H			O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	812					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						AATTCTGGCTGATATCGAGTA	0.597000													37	66					0	0	1	0	0
BBOX1	8424	broad.mit.edu	37	11	27114841	27114841	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr11:27114841G>C	ENST00000263182.3	+	5	829	c.461G>C	c.(460-462)gGa>gCa	p.G154A	BBOX1_ENST00000528583.1_Missense_Mutation_p.G154A|RP11-1L12.3_ENST00000530430.1_RNA|RP11-1L12.3_ENST00000525302.1_RNA|RP11-1L12.3_ENST00000526061.1_RNA|BBOX1_ENST00000527505.1_Intron|BBOX1_ENST00000525090.1_Missense_Mutation_p.G154A|BBOX1_ENST00000529202.1_Missense_Mutation_p.G154A	NM_003986.2	NP_003977.1	O75936	BODG_HUMAN	butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1	154					carnitine biosynthetic process	actin cytoskeleton|cytosol|intracellular membrane-bounded organelle	gamma-butyrobetaine dioxygenase activity|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			breast(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	23					Succinic acid(DB00139)|Vitamin C(DB00126)	AGACTCACCGGAGCATCTGAC	0.423000													51	67					0	0	1	0	0
NCAM1	4684	broad.mit.edu	37	11	113085174	113085174	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr11:113085174G>A	ENST00000316851.7	+	7	970	c.970G>A	c.(970-972)Gac>Aac	p.D324N	NCAM1_ENST00000533760.1_Missense_Mutation_p.D216N|NCAM1_ENST00000397957.4_3'UTR|NCAM1_ENST00000401611.2_Missense_Mutation_p.D333N	NM_001242607.1|NM_181351.4	NP_001229536.1|NP_851996.2	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1	334	Ig-like C2-type 4.				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(27)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	49		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		AGCCTCCGGAGACCCCATTCC	0.493000													8	11					0	0	1	0	0
CCDC148	130940	broad.mit.edu	37	2	159195284	159195284	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:159195284G>C	ENST00000283233.5	-	7	1031	c.718C>G	c.(718-720)Cag>Gag	p.Q240E	CCDC148_ENST00000409187.1_Missense_Mutation_p.Q249E|CCDC148_ENST00000409889.1_Missense_Mutation_p.Q240E|CCDC148_ENST00000536771.1_Missense_Mutation_p.Q154E	NM_138803.3	NP_620158.3	Q8NFR7	CC148_HUMAN	coiled-coil domain containing 148	240										endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23						AGCTTCTTCTGATATTTCTGT	0.343000													39	66					0	0	1	0	0
CASZ1	54897	broad.mit.edu	37	1	10713833	10713833	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:10713833C>T	ENST00000377022.3	-	11	2598	c.2281G>A	c.(2281-2283)Ggg>Agg	p.G761R	CASZ1_ENST00000344008.5_Missense_Mutation_p.G761R|RP4-734G22.3_ENST00000606802.1_RNA	NM_001079843.2	NP_001073312.1	Q86V15	CASZ1_HUMAN	castor zinc finger 1	761					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|large_intestine(13)|lung(18)|ovary(2)|prostate(5)|skin(2)|urinary_tract(1)	54	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		GCACTGGGCCCAGCCTCGGTG	0.692000													20	63					0	0	1	0	0
UBR4	23352	broad.mit.edu	37	1	19447887	19447887	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:19447887C>T	ENST00000375267.2	-	68	9940	c.9937G>A	c.(9937-9939)Gag>Aag	p.E3313K	UBR4_ENST00000375217.2_Missense_Mutation_p.E3306K|UBR4_ENST00000375226.2_Missense_Mutation_p.E3289K|UBR4_ENST00000375254.3_Missense_Mutation_p.E3313K			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	3313					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		GACACGCCCTCATCCACAAGG	0.592000													22	31					0	0	1	0	0
NEK4	6787	broad.mit.edu	37	3	52799959	52799959	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:52799959G>A	ENST00000233027.5	-	4	812	c.610C>T	c.(610-612)Cat>Tat	p.H204Y	NEK4_ENST00000535191.1_Missense_Mutation_p.H115Y|NEK4_ENST00000383721.4_Missense_Mutation_p.H204Y	NM_001193533.1|NM_003157.4	NP_001180462.1|NP_003148.2	P51957	NEK4_HUMAN	NIMA-related kinase 4	204	Protein kinase.				cell division|mitosis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(10)	26				BRCA - Breast invasive adenocarcinoma(193;7.44e-05)|Kidney(197;0.000711)|KIRC - Kidney renal clear cell carcinoma(197;0.00086)|OV - Ovarian serous cystadenocarcinoma(275;0.0513)		TTGAAAGCATGCTTCAAGGTG	0.333000													79	98					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	6985581	6985581	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr18:6985581C>G	ENST00000389658.3	-	38	5534	c.5441G>C	c.(5440-5442)aGa>aCa	p.R1814T		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	1814	Domain II and I.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TATCAATCCTCTTCCTTGGAC	0.413000													77	136					0	0	1	0	0
PPP2R2B	5521	broad.mit.edu	37	5	145969708	145969708	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr5:145969708C>T	ENST00000394413.3	-	9	1704	c.1134G>A	c.(1132-1134)tcG>tcA	p.S378S	PPP2R2B_ENST00000530902.1_5'UTR|PPP2R2B_ENST00000508545.2_Silent_p.S367S|PPP2R2B_ENST00000394409.3_Silent_p.S436S|PPP2R2B_ENST00000504198.1_Silent_p.S384S|PPP2R2B_ENST00000394411.4_Silent_p.S378S|PPP2R2B_ENST00000453001.1_Silent_p.S378S|PPP2R2B_ENST00000356826.3_Silent_p.S378S|PPP2R2B_ENST00000394410.2_Silent_p.S367S|PPP2R2B_ENST00000394414.1_Silent_p.S444S|PPP2R2B_ENST00000336640.6_Silent_p.S381S|CTB-99A3.1_ENST00000512730.1_RNA			Q00005	2ABB_HUMAN	protein phosphatase 2, regulatory subunit B, beta	378					apoptosis|signal transduction	cytoskeleton|mitochondrial outer membrane|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(9)|ovary(1)|prostate(4)|skin(3)	32			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGTTTTCCCTCGAAGCCTCAA	0.517000													72	111					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141243003	141243003	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:141243003C>T	ENST00000389484.3	-	59	10305	c.9334G>A	c.(9334-9336)Gaa>Aaa	p.E3112K		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3112					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTGGATACTTCAATGATTCTT	0.408000										TSP Lung(27;0.18)			59	33					0	0	1	0	0
C9orf163	158055	broad.mit.edu	37	9	139379442	139379442	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr9:139379442G>C	ENST00000354376.1	+	1	1496	c.542G>C	c.(541-543)aGa>aCa	p.R181T		NM_152571.2	NP_689784.1	Q8N9P6	CI163_HUMAN	chromosome 9 open reading frame 163	181							protein binding			kidney(1)|lung(1)	2		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;4.36e-06)|Epithelial(140;5.65e-06)		AAGAACCCAAGAGCCAGGAGC	0.602000											OREG0019617	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	30					0	0	1	0	0
CASZ1	54897	broad.mit.edu	37	1	10714202	10714202	+	Missense_Mutation	SNP	C	C	T	rs139056324	byFrequency	TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:10714202C>T	ENST00000377022.3	-	11	2229	c.1912G>A	c.(1912-1914)Gat>Aat	p.D638N	CASZ1_ENST00000344008.5_Missense_Mutation_p.D638N|RP4-734G22.3_ENST00000606802.1_RNA	NM_001079843.2	NP_001073312.1	Q86V15	CASZ1_HUMAN	castor zinc finger 1	638					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|large_intestine(13)|lung(18)|ovary(2)|prostate(5)|skin(2)|urinary_tract(1)	54	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		GCGTAGGCATCGTCCTTGATG	0.532000													36	53					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61829868	61829868	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr10:61829868C>T	ENST00000280772.2	-	37	10962	c.10771G>A	c.(10771-10773)Gaa>Aaa	p.E3591K	ANK3_ENST00000355288.2_Intron|ANK3_ENST00000373827.2_Intron|ANK3_ENST00000503366.1_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)						establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GGGGTACTTTCATCAGTTGGC	0.483000													65	109					0	0	1	0	0
KIAA1033	23325	broad.mit.edu	37	12	105508984	105508984	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr12:105508984G>C	ENST00000332180.5	+	5	431	c.344G>C	c.(343-345)gGt>gCt	p.G115A		NM_015275.1	NP_056090.1	Q2M389	WAHS7_HUMAN	KIAA1033	115					endosome transport	WASH complex				breast(3)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|lung(15)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	41						TTTTACAATGGTCTCTTGTTT	0.269000													23	109					0	0	1	0	0
CELF3	11189	broad.mit.edu	37	1	151678705	151678705	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:151678705C>G	ENST00000290583.4	-	10	1914	c.1121G>C	c.(1120-1122)aGa>aCa	p.R374T	CELF3_ENST00000392706.3_Missense_Mutation_p.R169T|CELF3_ENST00000470688.1_5'UTR|RP11-98D18.1_ENST00000457548.1_RNA|CELF3_ENST00000290585.4_Missense_Mutation_p.R324T	NM_001172648.1|NM_007185.4	NP_001166119.1|NP_009116.3	Q5SZQ8	CELF3_HUMAN	CUGBP, Elav-like family member 3	374					nuclear mRNA splicing, via spliceosome|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	mRNA binding|nucleotide binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)	21						AGCACCTTCTCTTtgctgctg	0.662000													5	24					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62286735	62286735	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr11:62286735C>G	ENST00000378024.4	-	5	15428	c.15154G>C	c.(15154-15156)Gat>Cat	p.D5052H	AHNAK_ENST00000530124.1_Intron|AHNAK_ENST00000257247.7_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	5052					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				AGGCTGGCATCAATTTCACCC	0.443000													172	335					0	0	1	0	0
MR1	3140	broad.mit.edu	37	1	181003155	181003155	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:181003155G>A	ENST00000367580.5	+	1	17	c.12G>A	c.(10-12)ctG>ctA	p.L4L	MR1_ENST00000367579.3_Silent_p.L4L|MR1_ENST00000282990.6_Silent_p.L4L|MR1_ENST00000438435.2_3'UTR|MR1_ENST00000434571.2_Silent_p.L4L	NM_001531.2	NP_001522.1	Q95460	HMR1_HUMAN	major histocompatibility complex, class I-related	4					antigen processing and presentation of peptide antigen via MHC class I|immune response	endoplasmic reticulum|extracellular region|integral to membrane|MHC class I protein complex	MHC class I receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(2)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	18						TGGGGGAACTGATGGCGTTCC	0.488000													16	57					0	0	1	0	0
DVL3	1857	broad.mit.edu	37	3	183885729	183885729	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:183885729C>T	ENST00000313143.3	+	13	1622	c.1374C>T	c.(1372-1374)ttC>ttT	p.F458F	DVL3_ENST00000431765.1_Silent_p.F441F|EIF2B5_ENST00000444495.1_Intron	NM_004423.3	NP_004414.3	Q92997	DVL3_HUMAN	dishevelled segment polarity protein 3	458	DEP.				canonical Wnt receptor signaling pathway|intracellular signal transduction|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent	cytoplasm	beta-catenin binding|frizzled binding|protease binding|protein heterodimerization activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(11)|large_intestine(6)|liver(1)|lung(13)|ovary(1)|prostate(1)	35	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.08e-34)|OV - Ovarian serous cystadenocarcinoma(80;1.31e-22)			TGGAAGGCTTCACGGACCGGA	0.582000													37	55					0	0	1	0	0
FSCN1	6624	broad.mit.edu	37	7	5642908	5642908	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr7:5642908C>G	ENST00000382361.3	+	2	967	c.853C>G	c.(853-855)Cag>Gag	p.Q285E	FSCN1_ENST00000340250.6_Missense_Mutation_p.Q264E	NM_003088.3	NP_003079.1	Q16658	FSCN1_HUMAN	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)	285					actin filament bundle assembly|cell migration|cell proliferation	cell junction|cytoplasm|filopodium|invadopodium|stress fiber	actin filament binding|drug binding|protein binding, bridging			central_nervous_system(1)|kidney(3)|large_intestine(1)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	9		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;1.21e-13)		GTCTGCCAATCAGGACGAGGA	0.607000													38	62					0	0	1	0	0
MBD1	4152	broad.mit.edu	37	18	47799841	47799841	+	Splice_Site	SNP	C	C	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr18:47799841C>A	ENST00000591416.1	-	13	1878	c.1447G>T	c.(1447-1449)Gag>Tag	p.E483*	MBD1_ENST00000457839.2_Splice_Site_p.E508*|MBD1_ENST00000353909.3_Splice_Site_p.E434*|MBD1_ENST00000269471.5_Intron|MBD1_ENST00000585595.1_Splice_Site_p.E508*|MBD1_ENST00000347968.3_Splice_Site_p.E427*|MBD1_ENST00000398488.1_Intron|MBD1_ENST00000591535.1_Intron|MBD1_ENST00000398495.2_Splice_Site_p.E452*|MBD1_ENST00000424334.2_Splice_Site_p.E534*|MBD1_ENST00000588937.1_Intron|MBD1_ENST00000339998.6_Intron|MBD1_ENST00000436910.1_Intron|MBD1_ENST00000398493.1_Splice_Site_p.E427*|MBD1_ENST00000587605.1_Intron|MBD1_ENST00000590208.1_Splice_Site_p.E483*|MBD1_ENST00000349085.2_Intron|MBD1_ENST00000585672.1_Splice_Site_p.E433*|MBD1_ENST00000382948.5_Splice_Site_p.E483*|MBD1_ENST00000269468.5_Splice_Site_p.E483*			Q9UIS9	MBD1_HUMAN	methyl-CpG binding domain protein 1	483					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|nuclear speck	methyl-CpG binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36						CACTGGGCCTCCTGCGTGAGG	0.627000													33	77					5.71845e-15	5.91052e-15	1	1	0
ZDHHC19	131540	broad.mit.edu	37	3	195937533	195937533	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:195937533G>A	ENST00000296326.3	-	2	301	c.222C>T	c.(220-222)ttC>ttT	p.F74F	ZDHHC19_ENST00000488508.1_5'UTR	NM_001039617.1	NP_001034706.1	Q8WVZ1	ZDH19_HUMAN	zinc finger, DHHC-type containing 19	74						integral to membrane	acyltransferase activity|zinc ion binding			breast(1)|endometrium(1)|large_intestine(1)|liver(1)|lung(7)|ovary(3)	14	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.89e-25)|all cancers(36;1.46e-23)|OV - Ovarian serous cystadenocarcinoma(49;2.1e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0022)		AAACAAGACTGAAGAAGGTAA	0.557000													32	69					0	0	1	0	0
BAIAP2	10458	broad.mit.edu	37	17	79079921	79079921	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr17:79079921G>A	ENST00000321300.6	+	11	1405	c.1312G>A	c.(1312-1314)Gat>Aat	p.D438N	BAIAP2_ENST00000321280.7_Missense_Mutation_p.D438N|BAIAP2_ENST00000575245.1_Missense_Mutation_p.D471N|BAIAP2_ENST00000435091.3_Missense_Mutation_p.D438N|BAIAP2_ENST00000416299.2_Missense_Mutation_p.D301N|BAIAP2_ENST00000575712.1_Missense_Mutation_p.D438N|BAIAP2_ENST00000392411.3_Missense_Mutation_p.D360N|BAIAP2_ENST00000428708.2_Missense_Mutation_p.D438N	NM_001144888.1|NM_017451.2	NP_001138360.1|NP_059345.1	Q9UQB8	BAIP2_HUMAN	BAI1-associated protein 2	438					axonogenesis|filopodium assembly|insulin receptor signaling pathway|regulation of actin cytoskeleton organization|response to bacterium	cell junction|cytoskeleton|cytosol|filopodium|nucleus|ruffle	cytoskeletal adaptor activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(6)|skin(1)	18	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			CTTGGACAGCGATGGCAGTGA	0.647000													3	7					0	0	1	0	0
GALNT15	117248	broad.mit.edu	37	3	16254109	16254109	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:16254109C>A	ENST00000339732.5	+	6	1734	c.1231C>A	c.(1231-1233)Ccc>Acc	p.P411T	GALNT15_ENST00000437509.1_Missense_Mutation_p.P411T	NM_054110.4	NP_473451.3			UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15																		TGAAATCCTTCCCTGCTCTCG	0.552000													18	45					1.87028e-06	1.88701e-06	1	1	0
NIN	51199	broad.mit.edu	37	14	51196399	51196399	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr14:51196399G>C	ENST00000245441.5	-	29	6110	c.5920C>G	c.(5920-5922)Cat>Gat	p.H1974D	NIN_ENST00000324330.9_3'UTR|NIN_ENST00000453196.1_Missense_Mutation_p.H1974D|NIN_ENST00000382041.3_Missense_Mutation_p.H1974D|NIN_ENST00000382043.4_Missense_Mutation_p.H1261D|NIN_ENST00000530997.2_Missense_Mutation_p.H1974D|NIN_ENST00000389868.3_3'UTR	NM_020921.3	NP_065972	Q8N4C6	NIN_HUMAN	ninein (GSK3B interacting protein)	1974					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(13)|lung(16)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	71	all_epithelial(31;0.00244)|Breast(41;0.127)					TCCCAAGCATGAGGGGACGGG	0.597000			T	PDGFRB	MPD								5	21					0	0	1	0	0
GSPT2	23708	broad.mit.edu	37	X	51488598	51488598	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chrX:51488598G>C	ENST00000340438.4	+	1	2118	c.1876G>C	c.(1876-1878)Gag>Cag	p.E626Q		NM_018094.4	NP_060564.2	Q8IYD1	ERF3B_HUMAN	G1 to S phase transition 2	626					cell cycle|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|translational termination	cytoplasm	GTP binding|GTPase activity|protein binding			breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	20	Ovarian(276;0.236)					ATTGGTCCCAGAGAAGGACTA	0.413000													32	7					0	0	1	0	0
FBXW7	55294	broad.mit.edu	37	4	153249370	153249370	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr4:153249370G>A	ENST00000281708.4	-	9	2637	c.1408C>T	c.(1408-1410)Cat>Tat	p.H470Y	FBXW7_ENST00000263981.5_Missense_Mutation_p.H390Y|FBXW7_ENST00000603841.1_Missense_Mutation_p.H470Y|FBXW7_ENST00000296555.5_Missense_Mutation_p.H352Y|FBXW7_ENST00000393956.3_Missense_Mutation_p.H294Y|FBXW7_ENST00000603548.1_Missense_Mutation_p.H470Y	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	470					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.?(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				CTTTTTTCATGAAGATGCATA	0.413000			"""Mis, N, D, F"""		"""colorectal, endometrial, T-ALL"""								40	92					0	0	1	0	0
THG1L	54974	broad.mit.edu	37	5	157158483	157158483	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr5:157158483C>G	ENST00000231198.7	+	1	279	c.35C>G	c.(34-36)tCc>tGc	p.S12C		NM_017872.3	NP_060342.2	Q9NWX6	THG1_HUMAN	tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)	12					protein homotetramerization|tRNA modification	mitochondrion	GTP binding|metal ion binding|tRNA guanylyltransferase activity			NS(1)|central_nervous_system(2)|kidney(1)|large_intestine(1)|lung(5)|prostate(2)|skin(1)	13	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GTTCACGATTCCTTGGCCACC	0.552000													41	93					0	0	1	0	0
ZNHIT1	10467	broad.mit.edu	37	7	100866969	100866969	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr7:100866969G>A	ENST00000305105.2	+	4	817	c.289G>A	c.(289-291)Gag>Aag	p.E97K	ZNHIT1_ENST00000492315.1_3'UTR	NM_006349.2	NP_006340.1	O43257	ZNHI1_HUMAN	zinc finger, HIT-type containing 1	97							metal ion binding|protein binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(2)	11	Lung NSC(181;0.168)|all_lung(186;0.215)					GAGTGTGGCCGAGGGCCCTAA	0.672000													43	92					0	0	1	0	0
SIRT5	23408	broad.mit.edu	37	6	13599382	13599382	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr6:13599382C>G	ENST00000606117.1	+	8	1032	c.736C>G	c.(736-738)Cta>Gta	p.L246V	SIRT5_ENST00000379262.4_Missense_Mutation_p.L246V|SIRT5_ENST00000397350.2_Missense_Mutation_p.L138V|SIRT5_ENST00000359782.3_Missense_Mutation_p.L228V	NM_012241.4	NP_036373.1	Q9NXA8	SIRT5_HUMAN	sirtuin 5	246	Deacetylase sirtuin-type.				chromatin silencing|protein ADP-ribosylation|protein deacetylation	mitochondrial intermembrane space|mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(3)|lung(1)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	11	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.176)		Suramin(DB04786)	TGATTTATGTCTAGTGGTGGG	0.542000													61	118					0	0	1	0	0
SYT11	23208	broad.mit.edu	37	1	155838469	155838469	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:155838469G>C	ENST00000368324.4	+	2	1001	c.748G>C	c.(748-750)Gac>Cac	p.D250H	SYT11_ENST00000539162.1_Intron	NM_152280.4	NP_689493.3	Q9BT88	SYT11_HUMAN	synaptotagmin XI	250	C2 1.					cell junction|synaptic vesicle membrane	protein binding|transporter activity			breast(2)|central_nervous_system(1)|endometrium(1)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;0.000162)			CCTCAGCTTTGACCGCTTCTC	0.572000													13	63					0	0	1	0	0
CD209	30835	broad.mit.edu	37	19	7808072	7808072	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:7808072G>A	ENST00000601256.1	-	4	982	c.883C>T	c.(883-885)Cgc>Tgc	p.R295C	CD209_ENST00000394173.4_Silent_p.C195C|CD209_ENST00000601951.1_Silent_p.C332C|CD209_ENST00000394161.5_Silent_p.C120C|CD209_ENST00000354397.6_Silent_p.C350C|CD209_ENST00000593660.1_Silent_p.C286C|CD209_ENST00000315599.7_Silent_p.C356C|CD209_ENST00000204801.8_Silent_p.C312C|CD209_ENST00000315591.8_Silent_p.C332C|CD209_ENST00000593821.1_Silent_p.C220C|CD209_ENST00000602261.1_Silent_p.C264C|CD209_ENST00000301357.8_Silent_p.C220C			Q9NNX6	CD209_HUMAN	CD209 molecule	0	C-type lectin.				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding			endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						TAAATTCCGCGCAGTCTTCCT	0.527000													126	248					0	0	1	0	0
HOXB6	3216	broad.mit.edu	37	17	46673804	46673804	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr17:46673804C>T	ENST00000484302.2	-	3	1268	c.646G>A	c.(646-648)Gag>Aag	p.E216K	HOXB-AS3_ENST00000481995.1_RNA|HOXB-AS3_ENST00000477144.1_RNA|HOXB-AS3_ENST00000474040.1_RNA|HOXB-AS3_ENST00000467155.2_RNA|HOXB-AS3_ENST00000487849.3_RNA|HOXB-AS3_ENST00000429755.4_RNA|HOXB-AS3_ENST00000465846.2_RNA|HOXB-AS3_ENST00000474324.1_RNA|HOXB-AS3_ENST00000492897.3_RNA|HOXB-AS3_ENST00000480872.1_RNA|HOXB3_ENST00000552000.2_Intron|HOXB6_ENST00000225648.3_Missense_Mutation_p.E216K|HOXB-AS3_ENST00000476204.1_RNA|HOXB-AS3_ENST00000466037.2_RNA|HOXB-AS3_ENST00000460041.1_RNA			P17509	HXB6_HUMAN	homeobox B6	216	Poly-Glu.				anterior/posterior axis specification, embryo	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|kidney(1)|large_intestine(1)|lung(4)	7						TCCTCCTCCTCGGCACTGAGC	0.597000													107	214					0	0	1	0	0
TUBB2A	7280	broad.mit.edu	37	6	3154828	3154828	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr6:3154828C>T	ENST00000333628.3	-	4	669	c.607G>A	c.(607-609)Gat>Aat	p.D203N	TUBB2A_ENST00000489942.1_5'UTR	NM_001069.2	NP_001060.1	Q13885	TBB2A_HUMAN	tubulin, beta 2A class IIa	203					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			endometrium(2)|large_intestine(4)|lung(2)|skin(1)	9	Ovarian(93;0.0386)	all_hematologic(90;0.0895)				GCCTCGTTATCAATGGAGTAG	0.592000													114	224					0	0	1	0	0
OCA2	4948	broad.mit.edu	37	15	28171347	28171347	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr15:28171347C>T	ENST00000354638.3	-	19	2160	c.2005G>A	c.(2005-2007)Gat>Aat	p.D669N	OCA2_ENST00000353809.5_Missense_Mutation_p.D645N	NM_000275.2	NP_000266.2	Q04671	P_HUMAN	oculocutaneous albinism II	669					eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(48)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		ATCTCAAAATCATGAATATCA	0.368000									Oculocutaneous Albinism				27	83					0	0	1	0	0
CGNL1	84952	broad.mit.edu	37	15	57744453	57744453	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr15:57744453G>A	ENST00000281282.5	+	6	2098	c.2020G>A	c.(2020-2022)Gaa>Aaa	p.E674K		NM_001252335.1|NM_032866.4	NP_001239264.1|NP_116255.2	Q0VF96	CGNL1_HUMAN	cingulin-like 1	674						myosin complex|tight junction	motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(14)|ovary(4)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)	60				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		ACGACTGGAAGAAAGTGAAGG	0.493000													23	24					0	0	1	0	0
FERMT1	55612	broad.mit.edu	37	20	6078252	6078252	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr20:6078252G>A	ENST00000217289.4	-	7	1664	c.876C>T	c.(874-876)ctC>ctT	p.L292L	FERMT1_ENST00000536936.1_Silent_p.L35L	NM_017671.4	NP_060141.3	Q9BQL6	FERM1_HUMAN	fermitin family member 1	292	FERM.				cell adhesion|establishment of epithelial cell polarity|keratinocyte migration|keratinocyte proliferation	cytosol|focal adhesion|ruffle membrane	binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	17						CTTGCTCATAGAGTTGGTTTA	0.398000													56	92					0	0	1	0	0
TRIM9	114088	broad.mit.edu	37	14	51561040	51561040	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr14:51561040C>A	ENST00000298355.3	-	1	1739	c.618G>T	c.(616-618)aaG>aaT	p.K206N	TRIM9_ENST00000360392.4_Missense_Mutation_p.K206N|TRIM9_ENST00000338969.5_Missense_Mutation_p.K206N	NM_015163.5	NP_055978.4	Q9C026	TRIM9_HUMAN	tripartite motif containing 9	206					proteasomal ubiquitin-dependent protein catabolic process	cell junction|cytoskeleton|dendrite|synaptic vesicle	protein homodimerization activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_epithelial(31;0.00418)|Breast(41;0.148)					CCAGGCGGTGCTTGGCTAGGG	0.682000													8	31					0.0381472	0.0382037	1	1	0
BCL11A	53335	broad.mit.edu	37	2	60689190	60689190	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:60689190T>C	ENST00000335712.6	-	4	1084	c.857A>G	c.(856-858)gAg>gGg	p.E286G	BCL11A_ENST00000359629.5_Intron|BCL11A_ENST00000356842.4_Missense_Mutation_p.E286G|BCL11A_ENST00000537768.1_Intron|BCL11A_ENST00000538214.1_Missense_Mutation_p.E252G|BCL11A_ENST00000358510.4_Missense_Mutation_p.E252G|BCL11A_ENST00000477659.1_5'UTR	NM_022893.3	NP_075044.2	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A (zinc finger protein)	286	Pro-rich.				negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			CAGGGCCATCTCTTCCGCCCC	0.617000			T	IGH@	B-CLL								24	80					0	0	1	0	0
ZNF90	7643	broad.mit.edu	37	19	20229375	20229375	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:20229375G>C	ENST00000418063.2	+	4	1124	c.1012G>C	c.(1012-1014)Gag>Cag	p.E338Q	ZNF90_ENST00000474284.1_Intron	NM_007138.1	NP_009069.1	Q03938	ZNF90_HUMAN	zinc finger protein 90	338						Golgi apparatus|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|lung(2)|ovary(1)|skin(1)	5						CCATACTGGAGAGAAACCCTA	0.423000													44	64					0	0	1	0	0
DVL3	1857	broad.mit.edu	37	3	183885783	183885783	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:183885783C>T	ENST00000313143.3	+	13	1676	c.1428C>T	c.(1426-1428)ttC>ttT	p.F476F	DVL3_ENST00000431765.1_Silent_p.F459F|EIF2B5_ENST00000444495.1_Intron	NM_004423.3	NP_004414.3	Q92997	DVL3_HUMAN	dishevelled segment polarity protein 3	476	DEP.				canonical Wnt receptor signaling pathway|intracellular signal transduction|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent	cytoplasm	beta-catenin binding|frizzled binding|protease binding|protein heterodimerization activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(11)|large_intestine(6)|liver(1)|lung(13)|ovary(1)|prostate(1)	35	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.08e-34)|OV - Ovarian serous cystadenocarcinoma(80;1.31e-22)			AAGCTGGCTTCATCCGCCATA	0.567000													61	103					0	0	1	0	0
NRCAM	4897	broad.mit.edu	37	7	107880462	107880462	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr7:107880462C>T	ENST00000379028.3	-	4	517	c.47G>A	c.(46-48)aGa>aAa	p.R16K	NRCAM_ENST00000425651.2_Missense_Mutation_p.R16K|NRCAM_ENST00000413765.2_Missense_Mutation_p.R16K|NRCAM_ENST00000379024.4_Missense_Mutation_p.R16K|NRCAM_ENST00000379022.4_Missense_Mutation_p.R16K|NRCAM_ENST00000351718.4_Missense_Mutation_p.R16K			Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule	16					angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding	p.R16K(2)		breast(4)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|liver(1)|lung(36)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	65						CAGGGGCACTCTGCCCGCAGA	0.433000													49	102					0	0	1	0	0
ARHGAP9	64333	broad.mit.edu	37	12	57866333	57866333	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr12:57866333C>T	ENST00000393797.2	-	21	2625	c.2433G>A	c.(2431-2433)ctG>ctA	p.L811L	ARHGAP9_ENST00000430041.2_Silent_p.L537L|ARHGAP9_ENST00000393791.3_Silent_p.L721L|ARHGAP9_ENST00000424809.2_3'UTR|ARHGAP9_ENST00000550288.1_3'UTR|ARHGAP9_ENST00000356411.2_Silent_p.L740L			Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9	740					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			endometrium(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(1)	30			GBM - Glioblastoma multiforme(3;3.37e-34)			TGGTGAGCATCAGCTGGACCA	0.542000													31	52					0	0	1	0	0
C10orf10	11067	broad.mit.edu	37	10	45472912	45472912	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr10:45472912G>A	ENST00000298295.3	-	2	784	c.567C>T	c.(565-567)tcC>tcT	p.S189S	RASSF4_ENST00000374417.2_Intron|RASSF4_ENST00000334940.6_Intron|RASSF4_ENST00000340258.5_Intron|RASSF4_ENST00000472561.1_Intron|C10orf10_ENST00000496638.1_Intron	NM_007021.3	NP_008952.1	Q9NTK1	DEPP_HUMAN	chromosome 10 open reading frame 10	189						mitochondrion				lung(1)	1						GGCGGTGGCGGGAGGCCATGG	0.617000													58	76					0	0	1	0	0
TSIX	9383	broad.mit.edu	37	X	73045181	73045181	+	RNA	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chrX:73045181G>C	ENST00000604411.1	+	0	33142				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						ATATCCTTTTGAAAGAGCACT	0.318000													40	15					0	0	1	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21028355	21028355	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr12:21028355G>A	ENST00000381545.3	+	9	1133	c.914G>A	c.(913-915)aGa>aAa	p.R305K	SLCO1B3_ENST00000553473.1_Missense_Mutation_p.R305K|SLCO1B7_ENST00000554957.1_Intron|LST3_ENST00000381541.3_Intron|LST3_ENST00000540229.1_Missense_Mutation_p.R305K|SLCO1B3_ENST00000261196.2_Missense_Mutation_p.R305K	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	305					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					AATGATGATAGAAATCAAACA	0.308000													27	67					0	0	1	0	0
KIF1A	547	broad.mit.edu	37	2	241689927	241689927	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:241689927G>A	ENST00000498729.2	-	28	3142	c.2896C>T	c.(2896-2898)Ccc>Tcc	p.P966S	KIF1A_ENST00000320389.7_Missense_Mutation_p.P865S	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	865					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		TGTACCAGGGGAACGGGGTAC	0.657000													24	14					0	0	1	0	0
ZBTB49	166793	broad.mit.edu	37	4	4303794	4303794	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr4:4303794G>A	ENST00000337872.4	+	3	352	c.231G>A	c.(229-231)caG>caA	p.Q77Q	ZBTB49_ENST00000355834.3_Silent_p.Q77Q|ZBTB49_ENST00000538529.1_5'UTR	NM_145291.3	NP_660334.3	Q6ZSB9	ZBT49_HUMAN	zinc finger and BTB domain containing 49	77	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	28						GCATAGGGCAGATCCTGGACT	0.388000													55	75					0	0	1	0	0
DVL1	1855	broad.mit.edu	37	1	1274001	1274001	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:1274001C>T	ENST00000378888.5	-	12	1524	c.1240G>A	c.(1240-1242)Gac>Aac	p.D414N	DVL1_ENST00000378891.5_Missense_Mutation_p.D389N			O14640	DVL1_HUMAN	dishevelled segment polarity protein 1	414					canonical Wnt receptor signaling pathway|dendrite morphogenesis|intracellular signal transduction|negative regulation of protein binding|negative regulation of protein kinase activity|neural tube development|neuromuscular junction development|neurotransmitter secretion|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway|protein localization to nucleus|receptor clustering|transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, planar cell polarity pathway	cytoplasmic membrane-bounded vesicle|cytosol|plasma membrane|synapse|synaptosome	frizzled binding|identical protein binding|protein kinase binding|signal transducer activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	13	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GCGCTCATGTCACTCTTCACC	0.647000													20	18					0	0	1	0	0
CBX5	23468	broad.mit.edu	37	12	54645865	54645865	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr12:54645865G>A	ENST00000209875.4	-	3	420	c.284C>T	c.(283-285)tCa>tTa	p.S95L	CBX5_ENST00000439541.2_Missense_Mutation_p.S95L|CBX5_ENST00000550411.1_Missense_Mutation_p.S95L	NM_012117.2	NP_036249.1	P45973	CBX5_HUMAN	chromobox homolog 5	95					blood coagulation|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|nuclear centromeric heterochromatin|nuclear envelope|nucleolus|transcriptional repressor complex	methylated histone residue binding|protein binding, bridging|repressing transcription factor binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|prostate(1)|skin(2)	8						GGCACTGTTTGAGAAATTGGA	0.328000													92	182					0	0	1	0	0
STAC	6769	broad.mit.edu	37	3	36527655	36527655	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:36527655G>A	ENST00000273183.3	+	5	901	c.601G>A	c.(601-603)Gag>Aag	p.E201K	STAC_ENST00000476388.1_3'UTR|STAC_ENST00000457375.2_Missense_Mutation_p.E140K	NM_003149.1	NP_003140.1	Q99469	STAC_HUMAN	SH3 and cysteine rich domain	201					intracellular signal transduction	cytoplasm|soluble fraction	metal ion binding	p.E201*(1)		endometrium(5)|large_intestine(9)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(5)	32						CCCTGTCTACGAGACCCTCCG	0.552000													74	139					0	0	1	0	0
POFUT1	23509	broad.mit.edu	37	20	30803176	30803176	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr20:30803176G>A	ENST00000375749.3	+	3	413	c.351G>A	c.(349-351)tgG>tgA	p.W117*	POFUT1_ENST00000539210.1_Intron|POFUT1_ENST00000486717.1_3'UTR|POFUT1_ENST00000375730.3_Nonsense_Mutation_p.W117*	NM_015352.1	NP_056167.1	Q9H488	OFUT1_HUMAN	protein O-fucosyltransferase 1	117					fucose metabolic process|Notch signaling pathway|O-glycan processing|regulation of transcription, DNA-dependent	endoplasmic reticulum|membrane	peptide-O-fucosyltransferase activity			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|urinary_tract(1)	6			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CCACCCACTGGCCCCCTGAGA	0.592000													4	182					0	0	1	0	0
EVI5	7813	broad.mit.edu	37	1	92979317	92979317	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:92979317C>G	ENST00000370331.1	-	18	2338	c.2329G>C	c.(2329-2331)Gag>Cag	p.E777Q	EVI5_ENST00000543509.1_Missense_Mutation_p.E788Q|EVI5_ENST00000540033.1_Missense_Mutation_p.E777Q	NM_005665.4	NP_005656.4	O60447	EVI5_HUMAN	ecotropic viral integration site 5	777	Interaction with AURKB and INCENP.|Targeting to the centrosomes.				cell cycle|cell division|cell proliferation|multicellular organismal development	microtubule organizing center|nucleus|spindle	protein binding|Rab GTPase activator activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|prostate(1)|skin(1)	38		all_lung(203;0.00146)|Lung NSC(277;0.00565)|all_neural(321;0.185)|Melanoma(281;0.193)|Glioma(108;0.203)		Epithelial(280;8.09e-25)|OV - Ovarian serous cystadenocarcinoma(397;1.27e-22)|all cancers(265;1.74e-21)|GBM - Glioblastoma multiforme(16;0.00233)|BRCA - Breast invasive adenocarcinoma(282;0.211)		GTTTCGCTCTCACTACCATCT	0.478000													60	73					0	0	1	0	0
ALG13	79868	broad.mit.edu	37	X	110951458	110951458	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chrX:110951458C>T	ENST00000394780.3	+	4	599	c.587C>T	c.(586-588)cCt>cTt	p.P196L	ALG13_ENST00000251943.4_Missense_Mutation_p.P92L|ALG13-AS1_ENST00000430794.1_RNA	NM_001099922.2|NM_001257231.1	NP_001093392.1|NP_001244160.1	Q9NP73	ALG13_HUMAN	ALG13, UDP-N-acetylglucosaminyltransferase subunit	196					dolichol-linked oligosaccharide biosynthetic process|lipid glycosylation|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane	carbohydrate binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity			endometrium(2)|lung(10)|skin(1)	13						TTTCCTCTCCCTCTTACCCCC	0.473000													8	56					0	0	1	0	0
CLCN6	1185	broad.mit.edu	37	1	11893574	11893574	+	Silent	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:11893574C>G	ENST00000346436.6	+	14	1303	c.1251C>G	c.(1249-1251)gtC>gtG	p.V417V	CLCN6_ENST00000376496.3_Silent_p.V417V|CLCN6_ENST00000312413.6_3'UTR|CLCN6_ENST00000376487.3_Silent_p.V395V	NM_001286.3	NP_001277	P51797	CLCN6_HUMAN	chloride channel, voltage-sensitive 6	417					cell volume homeostasis|signal transduction	endosome membrane|integral to membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|prostate(2)|skin(4)	36	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000816)|KIRC - Kidney renal clear cell carcinoma(229;0.00268)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		CTTCTCAGGTCACAGAAGATG	0.468000													19	91					0	0	1	0	0
VASH1	22846	broad.mit.edu	37	14	77245314	77245314	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr14:77245314G>A	ENST00000167106.4	+	7	1684	c.1051G>A	c.(1051-1053)Gag>Aag	p.E351K	VASH1_ENST00000554743.1_5'UTR|RP11-488C13.6_ENST00000556368.1_RNA|RP11-488C13.7_ENST00000553758.1_lincRNA	NM_014909.4	NP_055724.1	Q7L8A9	VASH1_HUMAN	vasohibin 1	351	Involved in heparin-binding and antiangiogenic activity.				cell cycle arrest|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of endothelial cell proliferation	endoplasmic reticulum|extracellular space				breast(2)|endometrium(1)|large_intestine(1)|lung(1)|prostate(1)|stomach(1)|urinary_tract(3)	10			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0283)		GAAGACTTCCGAGCCCAAAGC	0.632000													64	121					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237666723	237666723	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:237666723G>C	ENST00000366574.2	+	22	2848	c.2531G>C	c.(2530-2532)aGa>aCa	p.R844T	RYR2_ENST00000542537.1_Missense_Mutation_p.R828T|RYR2_ENST00000360064.6_Missense_Mutation_p.R842T	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	844					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AAGCAAGAAAGAACTTACACA	0.502000													32	51					0	0	1	0	0
LPAR6	10161	broad.mit.edu	37	13	48985593	48985593	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr13:48985593C>T	ENST00000378434.4	-	7	2591	c.967G>A	c.(967-969)Gag>Aag	p.E323K	LPAR6_ENST00000345941.2_Missense_Mutation_p.E323K|RB1_ENST00000267163.4_Intron	NM_005767.5	NP_005758.2	P43657	LPAR6_HUMAN	lysophosphatidic acid receptor 6	323						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled	p.0?(15)|p.?(4)		NS(1)|endometrium(1)|large_intestine(4)|lung(1)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	14						ATAAAATTCTCTGCACCATGA	0.358000													99	90					0	0	1	0	0
COL4A6	1288	broad.mit.edu	37	X	107423779	107423779	+	Silent	SNP	C	C	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chrX:107423779C>A	ENST00000394872.2	-	25	2331	c.2100G>T	c.(2098-2100)ggG>ggT	p.G700G	COL4A6_ENST00000545689.1_Silent_p.G699G|COL4A6_ENST00000538570.1_Silent_p.G699G|COL4A6_ENST00000334504.7_Silent_p.G699G|COL4A6_ENST00000372216.4_Silent_p.G700G			Q14031	CO4A6_HUMAN	collagen, type IV, alpha 6	700	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(41)|ovary(7)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	92						ATCCTGGACTCCCTGGCTCTC	0.517000									Alport syndrome with Diffuse Leiomyomatosis				51	13					1.57914e-17	1.64474e-17	1	1	0
CACNA2D1	781	broad.mit.edu	37	7	81589093	81589093	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr7:81589093C>T	ENST00000356860.3	-	37	3357	c.3019G>A	c.(3019-3021)Gag>Aag	p.E1007K	CACNA2D1_ENST00000535308.1_Missense_Mutation_p.E219K|CACNA2D1_ENST00000356253.5_Missense_Mutation_p.E1019K	NM_000722.2	NP_000713.2	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 1	1019						voltage-gated calcium channel complex	metal ion binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(15)|liver(1)|lung(42)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	81					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	CCTTTGCTCTCAACCATTATG	0.368000													23	58					0	0	1	0	0
OARD1	221443	broad.mit.edu	37	6	41036642	41036642	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr6:41036642C>G	ENST00000479950.1	-	5	607	c.294G>C	c.(292-294)aaG>aaC	p.K98N	OARD1_ENST00000464633.1_Intron|OARD1_ENST00000463088.1_Missense_Mutation_p.K98N|OARD1_ENST00000486443.1_Missense_Mutation_p.K59N|OARD1_ENST00000373154.2_Intron|OARD1_ENST00000480585.1_Intron|OARD1_ENST00000468811.1_Missense_Mutation_p.K98N|OARD1_ENST00000244558.9_Intron|OARD1_ENST00000482515.1_Intron|OARD1_ENST00000424266.2_Missense_Mutation_p.K98N					O-acyl-ADP-ribose deacylase 1																		CCTCTAAACTCTTCTGTAAGT	0.398000													30	49					0	0	1	0	0
IMMT	10989	broad.mit.edu	37	2	86371654	86371654	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:86371654G>C	ENST00000410111.3	-	15	2401	c.2014C>G	c.(2014-2016)Cag>Gag	p.Q672E	IMMT_ENST00000442664.2_Missense_Mutation_p.Q671E|IMMT_ENST00000409051.2_Missense_Mutation_p.Q625E|IMMT_ENST00000449247.2_Missense_Mutation_p.Q661E|IMMT_ENST00000254636.5_Missense_Mutation_p.Q573E	NM_001100169.1|NM_001100170.1|NM_006839.2	NP_001093639.1|NP_001093640.1|NP_006830.2	Q16891	IMMT_HUMAN	inner membrane protein, mitochondrial	672						integral to mitochondrial inner membrane	protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						TTCAGTTGCTGAGGTGGGAAT	0.468000													57	71					0	0	1	0	0
PARG	8505	broad.mit.edu	37	10	51093329	51093329	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr10:51093329C>T	ENST00000402038.3	-	4	294	c.295G>A	c.(295-297)Gca>Aca	p.A99T		NM_003631.2	NP_003622.2	Q86W56	PARG_HUMAN	poly (ADP-ribose) glycohydrolase	584					carbohydrate metabolic process	nucleus	poly(ADP-ribose) glycohydrolase activity	p.A584T(1)		endometrium(5)|kidney(2)|lung(1)|ovary(2)	10				Epithelial(53;0.213)		TGAGCTTCTGCTTCTTCAAGT	0.318000													4	85					0	0	1	0	0
WWC1	23286	broad.mit.edu	37	5	167855779	167855779	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr5:167855779C>T	ENST00000265293.4	+	13	2489	c.1987C>T	c.(1987-1989)Cag>Tag	p.Q663*	WWC1_ENST00000521089.1_Nonsense_Mutation_p.Q663*	NM_001161661.1|NM_001161662.1|NM_015238.2	NP_001155133.1|NP_001155134.1|NP_056053.1	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1	663	C2.				cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(2)|prostate(1)|skin(4)	43	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		GACCCGAATTCAGATTGCCCT	0.542000													34	50					0	0	1	0	0
MX1	4599	broad.mit.edu	37	21	42824764	42824764	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr21:42824764G>A	ENST00000398600.2	+	18	2751	c.1726G>A	c.(1726-1728)Gag>Aag	p.E576K	MX1_ENST00000288383.6_Missense_Mutation_p.E553K|MX1_ENST00000455164.2_Missense_Mutation_p.E576K|MX1_ENST00000398598.3_Missense_Mutation_p.E576K	NM_001144925.1	NP_001138397.1	P20591	MX1_HUMAN	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	576	GED.				induction of apoptosis|response to virus|type I interferon-mediated signaling pathway	cytosol	GTP binding|GTPase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(9)|lung(5)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	27		Prostate(19;3.18e-07)|all_epithelial(19;0.0277)				TTCCATGGAGGAGATCTTTCA	0.498000													87	249					0	0	1	0	0
CD209	30835	broad.mit.edu	37	19	7810937	7810937	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:7810937G>A	ENST00000315599.7	-	4	237	c.215C>T	c.(214-216)tCc>tTc	p.S72F	CD209_ENST00000394173.4_Missense_Mutation_p.S72F|CD209_ENST00000601951.1_Missense_Mutation_p.S48F|CD209_ENST00000394161.5_Missense_Mutation_p.S72F|CD209_ENST00000354397.6_Missense_Mutation_p.S72F|CD209_ENST00000593660.1_Missense_Mutation_p.S48F|CD209_ENST00000204801.8_Missense_Mutation_p.S28F|CD209_ENST00000315591.8_Missense_Mutation_p.S48F|CD209_ENST00000593821.1_Missense_Mutation_p.S28F|CD209_ENST00000601256.1_Missense_Mutation_p.S48F|CD209_ENST00000602261.1_Missense_Mutation_p.S72F|CD209_ENST00000301357.8_Missense_Mutation_p.S28F	NM_001144895.1|NM_001144897.1|NM_021155.3	NP_001138367.1|NP_001138369.1|NP_066978.1	Q9NNX6	CD209_HUMAN	CD209 molecule	72					cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding			endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						GTCTTGCCTGGATTGTTCCTG	0.502000													60	150					0	0	1	0	0
KDM8	79831	broad.mit.edu	37	16	27224909	27224909	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr16:27224909G>A	ENST00000286096.4	+	3	675	c.502G>A	c.(502-504)Gca>Aca	p.A168T	CTD-3203P2.1_ENST00000567108.1_RNA|KDM8_ENST00000568965.1_Intron|KDM8_ENST00000380948.2_Intron|KDM8_ENST00000441782.2_Missense_Mutation_p.A206T	NM_024773.2	NP_079049.2	Q8N371	KDM8_HUMAN	lysine (K)-specific demethylase 8	168					G2/M transition of mitotic cell cycle|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	chromatin binding|histone demethylase activity (H3-K36 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen										TAAACAGAAAGCAAGGGCGGA	0.478000													66	46					0	0	1	0	0
FBXW5	54461	broad.mit.edu	37	9	139836610	139836610	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr9:139836610G>A	ENST00000325285.3	-	6	1063	c.984C>T	c.(982-984)gcC>gcT	p.A328A	FBXW5_ENST00000483559.1_5'UTR	NM_018998.3	NP_061871.1	Q969U6	FBXW5_HUMAN	F-box and WD repeat domain containing 5	328							catalytic activity|protein binding			breast(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	12	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.19)	OV - Ovarian serous cystadenocarcinoma(145;7.8e-06)|Epithelial(140;0.000106)		CCAGCAGCTCGGCCACCTTGG	0.677000													3	13					0	0	1	0	0
PTPRJ	5795	broad.mit.edu	37	11	48145334	48145334	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr11:48145334G>A	ENST00000418331.2	+	5	1138	c.786G>A	c.(784-786)ctG>ctA	p.L262L	PTPRJ_ENST00000440289.2_Silent_p.L262L	NM_002843.3	NP_002834.3	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	262	Fibronectin type-III 2.				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|endometrium(7)|kidney(7)|large_intestine(5)|lung(15)|ovary(1)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						TCTCGGGCCTGAAGCCAGGGG	0.488000													34	75					0	0	1	0	0
CERS5	91012	broad.mit.edu	37	12	50529517	50529517	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr12:50529517G>A	ENST00000317551.6	-	8	994	c.870C>T	c.(868-870)ttC>ttT	p.F290F	CERS5_ENST00000422340.2_Silent_p.F232F	NM_147190.2	NP_671723.1	Q8N5B7	CERS5_HUMAN	ceramide synthase 5	290	TLC.				ceramide biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity										CCACTTACCAGAATGGATAGA	0.413000													32	96					0	0	1	0	0
MCOLN1	57192	broad.mit.edu	37	19	7591392	7591392	+	Missense_Mutation	SNP	G	G	C	rs139377969	byFrequency	TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:7591392G>C	ENST00000264079.6	+	3	430	c.305G>C	c.(304-306)cGa>cCa	p.R102P		NM_020533.2	NP_065394.1	Q9GZU1	MCLN1_HUMAN	mucolipin 1	102					calcium ion transport|cellular iron ion homeostasis|transferrin transport	integral to plasma membrane|late endosome membrane|lysosomal membrane	cation channel activity|iron ion transmembrane transporter activity			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						ATCGCCTTCCGACACCTCTTC	0.587000													81	96					0	0	1	0	0
TOP3A	7156	broad.mit.edu	37	17	18194165	18194165	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr17:18194165C>G	ENST00000321105.5	-	12	1672	c.1458G>C	c.(1456-1458)tgG>tgC	p.W486C	TOP3A_ENST00000542570.1_Missense_Mutation_p.W391C|TOP3A_ENST00000540524.1_Missense_Mutation_p.W16C	NM_004618.3	NP_004609.1	Q13472	TOP3A_HUMAN	topoisomerase (DNA) III alpha	486					DNA topological change|meiosis	chromosome|PML body	ATP binding|DNA topoisomerase type I activity|protein binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(15)|ovary(1)|skin(6)|stomach(2)|urinary_tract(1)	36						CCTTGTCACTCCAGTGATCAT	0.498000													46	59					0	0	1	0	0
XXYLT1	152002	broad.mit.edu	37	3	194991365	194991365	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:194991365G>A	ENST00000310380.6	-	1	531	c.423C>T	c.(421-423)ttC>ttT	p.F141F		NM_152531.4	NP_689744.3	Q8NBI6	CC021_HUMAN	xyloside xylosyltransferase 1	141						integral to membrane	transferase activity, transferring glycosyl groups										CCTCGCTCACGAAGTGAAGGT	0.711000													12	12					0	0	1	0	0
TNNT3	7140	broad.mit.edu	37	11	1955621	1955621	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr11:1955621G>A	ENST00000381558.1	+	11	681	c.402G>A	c.(400-402)aaG>aaA	p.K134K	TNNT3_ENST00000381549.3_Silent_p.K134K|TNNT3_ENST00000381589.3_Silent_p.K140K|TNNT3_ENST00000397304.2_Silent_p.K123K|TNNT3_ENST00000397301.1_Silent_p.K153K|TNNT3_ENST00000446240.1_Silent_p.K123K|TNNT3_ENST00000381561.4_Silent_p.K145K|TNNT3_ENST00000360603.3_Silent_p.K136K|TNNT3_ENST00000381548.3_Silent_p.K144K|TNNT3_ENST00000381579.3_Silent_p.K134K|TNNT3_ENST00000493234.1_3'UTR|TNNT3_ENST00000278317.6_Silent_p.K142K			P45378	TNNT3_HUMAN	troponin T type 3 (skeletal, fast)	153					muscle filament sliding|regulation of ATPase activity|regulation of striated muscle contraction|skeletal muscle contraction	cytosol|troponin complex	calcium-dependent protein binding|tropomyosin binding|troponin C binding|troponin I binding			breast(2)|endometrium(1)|kidney(1)|lung(8)|ovary(1)|prostate(1)|skin(4)|stomach(1)	19		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00253)|Lung(200;0.0333)|LUSC - Lung squamous cell carcinoma(625;0.0826)		ACGACCTGAAGAAGAAGAAAG	0.582000													15	34					0	0	1	0	0
BMPR2	659	broad.mit.edu	37	2	203417517	203417517	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:203417517G>C	ENST00000374580.4	+	11	2031	c.1492G>C	c.(1492-1494)Gag>Cag	p.E498Q	BMPR2_ENST00000374574.2_Missense_Mutation_p.E498Q	NM_001204.6	NP_001195.2	Q13873	BMPR2_HUMAN	bone morphogenetic protein receptor, type II (serine/threonine kinase)	498	Protein kinase.				anterior/posterior pattern formation|BMP signaling pathway|cellular response to starvation|lung alveolus development|mesoderm formation|negative regulation of cell growth|negative regulation of systemic arterial blood pressure|negative regulation of vasoconstriction|positive regulation of BMP signaling pathway|positive regulation of bone mineralization|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of epithelial cell migration|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of lung blood pressure|transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway	integral to plasma membrane	ATP binding|metal ion binding|transforming growth factor beta receptor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(11)|lung(7)|ovary(4)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(2)	42						ACAGTGTGCTGAGGAAAGGAT	0.463000													140	72					0	0	1	0	0
LOC728323	728323	broad.mit.edu	37	2	243037115	243037115	+	RNA	SNP	A	A	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:243037115A>G	ENST00000456398.1	+	0	247																											GGCTGGAAGAATTGTGAATCT	0.398000													4	109					0	0	1	0	0
SCYL2	55681	broad.mit.edu	37	12	100732781	100732781	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr12:100732781C>G	ENST00000360820.2	+	18	3058	c.2621C>G	c.(2620-2622)tCt>tGt	p.S874C		NM_017988.4	NP_060458.3	Q6P3W7	SCYL2_HUMAN	SCY1-like 2 (S. cerevisiae)	874	Necessary for interaction with AP2 complex and clathrin, interaction with clathrin is necessary for its targeting to the TGN and endosomal membranes.				endosome to lysosome transport|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of clathrin-mediated endocytosis|positive regulation of receptor internalization	clathrin-coated vesicle|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|protein kinase activity|receptor binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(4)|lung(15)|ovary(2)|skin(1)	41						CCTCAAGGTTCTCCAACTATG	0.418000													53	165					0	0	1	0	0
POLN	353497	broad.mit.edu	37	4	2210146	2210146	+	Silent	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr4:2210146G>C	ENST00000511885.2	-	5	635	c.282C>G	c.(280-282)gtC>gtG	p.V94V	POLN_ENST00000515357.1_5'UTR|POLN_ENST00000382865.1_Silent_p.V94V			Q7Z5Q5	DPOLN_HUMAN	polymerase (DNA directed) nu	94					DNA repair|DNA replication	nucleus	DNA binding|DNA-directed DNA polymerase activity			kidney(6)|large_intestine(5)|liver(1)|lung(8)|ovary(2)|skin(4)|urinary_tract(2)	28			OV - Ovarian serous cystadenocarcinoma(23;0.0955)			CTGTGAGCCTGACACTGAAGG	0.393000								DNA polymerases (catalytic subunits)					65	78					0	0	1	0	0
IGKV1-9	28941	broad.mit.edu	37	2	89309936	89309936	+	RNA	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:89309936C>T	ENST00000493819.1	-	0	76																											AGGAGCTGAGCGGGGACCCTC	0.577000													62	135					0	0	1	0	0
NUDT22	84304	broad.mit.edu	37	11	63996766	63996766	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr11:63996766C>T	ENST00000279206.3	+	4	783	c.627C>T	c.(625-627)atC>atT	p.I209I	NUDT22_ENST00000441250.2_Silent_p.I176I|RP11-783K16.14_ENST00000534988.1_RNA	NM_001128612.2|NM_032344.2	NP_001122084.1|NP_115720	Q9BRQ3	NUD22_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 22	209	Nudix hydrolase.						hydrolase activity			breast(1)|endometrium(1)|large_intestine(2)|lung(4)	8						TGTTGGGCATCGCCCGAAATG	0.632000													9	15					0	0	1	0	0
BRD2	6046	broad.mit.edu	37	6	32944218	32944218	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr6:32944218C>A	ENST00000395289.2	+	6	2403	c.802C>A	c.(802-804)Cct>Act	p.P268T	BRD2_ENST00000374825.4_Missense_Mutation_p.P268T|BRD2_ENST00000443797.2_Missense_Mutation_p.P148T|BRD2_ENST00000374831.4_Missense_Mutation_p.P268T|BRD2_ENST00000449085.2_Missense_Mutation_p.P221T|BRD2_ENST00000395287.1_Missense_Mutation_p.P268T			P25440	BRD2_HUMAN	bromodomain containing 2	268					spermatogenesis	nucleus	protein serine/threonine kinase activity			central_nervous_system(3)|stomach(2)	5						TACTGCAGCTCCTCCAGCCCA	0.557000													40	52					1.96642e-18	2.05442e-18	1	1	0
WASH3P	374666	broad.mit.edu	37	15	102516455	102516455	+	RNA	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr15:102516455G>A	ENST00000557932.1	+	0	1403																				central_nervous_system(1)|endometrium(6)|kidney(11)|prostate(5)|stomach(1)|urinary_tract(1)	25						GGACGAGGACGACTGGGAATC	0.652000													4	88					0	0	1	0	0
FRYL	285527	broad.mit.edu	37	4	48502189	48502189	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr4:48502189C>T	ENST00000537810.1	-	63	9245	c.8641G>A	c.(8641-8643)Gaa>Aaa	p.E2881K	FRYL_ENST00000264319.7_Missense_Mutation_p.E271K|FRYL_ENST00000503238.1_Missense_Mutation_p.E2881K|FRYL_ENST00000507873.2_Missense_Mutation_p.E271K|FRYL_ENST00000358350.4_Missense_Mutation_p.E2881K			O94915	FRYL_HUMAN	FRY-like	2881					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(21)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	91						GACTCAGCTTCTTTGAGGATA	0.353000													23	60					0	0	1	0	0
NFATC2	4773	broad.mit.edu	37	20	50048947	50048947	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr20:50048947C>G	ENST00000371564.3	-	9	2598	c.2379G>C	c.(2377-2379)caG>caC	p.Q793H	NFATC2_ENST00000414705.1_Missense_Mutation_p.Q773H|NFATC2_ENST00000396009.3_Missense_Mutation_p.Q793H|NFATC2_ENST00000609943.1_Missense_Mutation_p.Q773H|NFATC2_ENST00000609507.1_Missense_Mutation_p.Q574H|NFATC2_ENST00000610033.1_Missense_Mutation_p.Q574H	NM_001258296.1|NM_012340.4	NP_001245225.1|NP_036472.2	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	793					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity		EWSR1/NFATC2(9)	breast(2)|endometrium(7)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	53	Hepatocellular(150;0.248)					GGGCTGAGCTCTGGCCCTGGG	0.697000													27	61					0	0	1	0	0
EIF2B5	8893	broad.mit.edu	37	3	183862399	183862399	+	Silent	SNP	C	C	T	rs113994086		TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:183862399C>T	ENST00000273783.3	+	15	2132	c.2010C>T	c.(2008-2010)ttC>ttT	p.F670F	EIF2B5_ENST00000444495.1_Silent_p.F670F	NM_003907.2	NP_003898.2	Q13144	EI2BE_HUMAN	eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa	670	W2.				astrocyte development|myelination|negative regulation of translational initiation in response to stress|oligodendrocyte development|ovarian follicle development|positive regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus|RNA metabolic process	cytosol|eukaryotic translation initiation factor 2B complex|nucleus	guanyl-nucleotide exchange factor activity|transferase activity|translation initiation factor activity|translation initiation factor binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(9)|ovary(5)|urinary_tract(1)	27	all_cancers(143;7.59e-11)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			TGATGGCTTTCTACCAGCTGG	0.522000													20	43					0	0	1	0	0
EPHA3	2042	broad.mit.edu	37	3	89521651	89521651	+	Missense_Mutation	SNP	A	A	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:89521651A>T	ENST00000336596.2	+	16	2953	c.2728A>T	c.(2728-2730)Atc>Ttc	p.I910F	EPHA3_ENST00000494014.1_Missense_Mutation_p.I910F	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	910						extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		CAATGTGGATATCACTACCTT	0.468000										TSP Lung(6;0.00050)			105	144					0	0	1	0	0
NRXN3	9369	broad.mit.edu	37	14	79175708	79175708	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr14:79175708A>G	ENST00000554719.1	+	4	742	c.251A>G	c.(250-252)tAc>tGc	p.Y84C	RP11-232C2.2_ENST00000555680.1_RNA|NRXN3_ENST00000335750.5_Missense_Mutation_p.Y84C	NM_004796.4	NP_004787.2	Q9HDB5	NRX3B_HUMAN	neurexin 3	0					angiogenesis|cell adhesion	integral to membrane		p.Y84S(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(23)|lung(40)|ovary(3)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(9)|urinary_tract(1)	104		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		CCAGAGGCTTACATCAGCTTG	0.502000													28	59					0	0	1	0	0
RSPH6A	81492	broad.mit.edu	37	19	46307533	46307533	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:46307533G>A	ENST00000221538.3	-	3	1772	c.1630C>T	c.(1630-1632)Cac>Tac	p.H544Y	RSPH6A_ENST00000600188.1_Missense_Mutation_p.H280Y|RSPH6A_ENST00000597055.1_Missense_Mutation_p.H544Y	NM_030785.3	NP_110412.1	Q9H0K4	RSH6A_HUMAN	radial spoke head 6 homolog A (Chlamydomonas)	544	Glu-rich.					intracellular				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	32						TGCTGTGTGTGATGCACCCAG	0.637000													36	55					0	0	1	0	0
ABCC8	6833	broad.mit.edu	37	11	17430001	17430001	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr11:17430001C>A	ENST00000302539.4	-	23	2886	c.2761G>T	c.(2761-2763)Gaa>Taa	p.E921*	ABCC8_ENST00000389817.3_Nonsense_Mutation_p.E920*	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	920	ABC transporter 1.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	AGCTGGCATTCAGACCTCTGG	0.567000													52	98					4.86159e-25	5.13463e-25	1	1	0
GPS1	2873	broad.mit.edu	37	17	80012789	80012789	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr17:80012789C>T	ENST00000392358.2	+	5	1094	c.745C>T	c.(745-747)Cag>Tag	p.Q249*	GPS1_ENST00000578552.1_Nonsense_Mutation_p.Q209*|GPS1_ENST00000306823.6_Nonsense_Mutation_p.Q213*|GPS1_ENST00000355130.2_Nonsense_Mutation_p.Q249*|GPS1_ENST00000320548.4_Nonsense_Mutation_p.Q193*	NM_212492.1	NP_997657.1	Q13098	CSN1_HUMAN	G protein pathway suppressor 1	213					cell cycle|cullin deneddylation|inactivation of MAPK activity|JNK cascade	cytoplasm|signalosome	GTPase inhibitor activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|liver(1)|lung(4)|prostate(1)|skin(2)	13	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0211)			CGTCTACTTGCAGAATTGGTC	0.672000													38	59					0	0	1	0	0
GARS	2617	broad.mit.edu	37	7	30649204	30649204	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr7:30649204G>C	ENST00000389266.3	+	7	980	c.739G>C	c.(739-741)Gat>Cat	p.D247H		NM_002047.2	NP_002038.2	P41250	SYG_HUMAN	glycyl-tRNA synthetase	247					cell death|diadenosine tetraphosphate biosynthetic process|glycyl-tRNA aminoacylation	cytosol|mitochondrial matrix|soluble fraction	ATP binding|glycine-tRNA ligase activity|protein dimerization activity			breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|skin(3)|urinary_tract(1)	24					Glycine(DB00145)	CTTTTAGCTTGATAACTATGG	0.333000													102	195					0	0	1	0	0
ZNF529	57711	broad.mit.edu	37	19	37038988	37038988	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:37038988G>C	ENST00000334116.7	-	6	767	c.157C>G	c.(157-159)Ctt>Gtt	p.L53V	ZNF529_ENST00000591340.1_Missense_Mutation_p.L158V	NM_001145650.1	NP_001139122.1	Q6P280	ZN529_HUMAN	zinc finger protein 529	125	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1	Esophageal squamous(110;0.198)					GGTAAAGTAAGAGATTCATGA	0.373000													54	72					0	0	1	0	0
ZNF114	163071	broad.mit.edu	37	19	48789265	48789265	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:48789265G>A	ENST00000595607.1	+	6	878	c.384G>A	c.(382-384)atG>atA	p.M128I	ZNF114_ENST00000600687.1_Missense_Mutation_p.M128I|ZNF114_ENST00000597695.1_Missense_Mutation_p.M94I|ZNF114_ENST00000315849.1_Missense_Mutation_p.M128I			Q8NC26	ZN114_HUMAN	zinc finger protein 114	128					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(6)|lung(11)	18		all_epithelial(76;8.01e-05)|all_lung(116;0.000112)|Lung NSC(112;0.000192)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;7.56e-05)|all cancers(93;0.000113)|Epithelial(262;0.00962)|GBM - Glioblastoma multiforme(486;0.0153)		ATCATGAAATGAGGAACCACT	0.448000													52	81					0	0	1	0	0
SLMAP	7871	broad.mit.edu	37	3	57898358	57898358	+	Silent	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:57898358G>C	ENST00000295951.3	+	18	3065	c.1848G>C	c.(1846-1848)ctG>ctC	p.L616L	SLMAP_ENST00000495364.1_Silent_p.L167L|SLMAP_ENST00000472546.1_3'UTR|SLMAP_ENST00000416870.1_Silent_p.L126L|SLMAP_ENST00000428312.1_Silent_p.L633L|SLMAP_ENST00000449503.2_Silent_p.L595L|SLMAP_ENST00000295952.3_Silent_p.L616L|SLMAP_ENST00000442599.2_Silent_p.L101L|SLMAP_ENST00000494088.1_Silent_p.L126L			Q14BN4	SLMAP_HUMAN	sarcolemma associated protein	633					muscle contraction|protein folding	integral to plasma membrane|microtubule organizing center|prefoldin complex|sarcolemma|smooth endoplasmic reticulum	unfolded protein binding			endometrium(5)|kidney(1)|large_intestine(3)|lung(7)|urinary_tract(2)	18				BRCA - Breast invasive adenocarcinoma(55;0.000271)|KIRC - Kidney renal clear cell carcinoma(284;0.0602)|Kidney(284;0.0754)|OV - Ovarian serous cystadenocarcinoma(275;0.182)		TCACAAGTCTGCAAAACAGTT	0.418000													33	54					0	0	1	0	0
FBXO27	126433	broad.mit.edu	37	19	39521925	39521925	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:39521925C>A	ENST00000292853.4	-	3	519	c.400G>T	c.(400-402)Gac>Tac	p.D134Y	FBXO27_ENST00000509137.2_Missense_Mutation_p.D134Y|FBXO27_ENST00000600828.1_Missense_Mutation_p.D133Y|CTB-189B5.3_ENST00000597303.1_RNA	NM_178820.3	NP_849142.1	Q8NI29	FBX27_HUMAN	F-box protein 27	134	FBA.				protein catabolic process	SCF ubiquitin ligase complex	glycoprotein binding			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(5)|ovary(1)|urinary_tract(2)	17	all_cancers(60;3.79e-07)|all_lung(34;1.26e-07)|Lung NSC(34;1.46e-07)|all_epithelial(25;4.69e-07)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			ACCCAGCCGTCCCCACCGTGT	0.567000													31	52					1.39806e-14	1.44061e-14	1	1	0
KIAA0196	9897	broad.mit.edu	37	8	126093934	126093934	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr8:126093934C>T	ENST00000318410.7	-	5	836	c.487G>A	c.(487-489)Gag>Aag	p.E163K	KIAA0196_ENST00000517845.1_Missense_Mutation_p.E15K	NM_014846.3	NP_055661.3	Q12768	STRUM_HUMAN	KIAA0196	163					cell death	WASH complex				NS(1)|breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	42	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			AGCATCCTCTCTCTGACTTCT	0.433000													63	72					0	0	1	0	0
EP300	2033	broad.mit.edu	37	22	41551100	41551100	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr22:41551100C>T	ENST00000263253.7	+	17	4463	c.3244C>T	c.(3244-3246)Cag>Tag	p.Q1082*		NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	1082	Bromo.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						TGTGGACCCTCAGCTTTTAGG	0.393000			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				149	79					0	0	1	0	0
YME1L1	10730	broad.mit.edu	37	10	27406597	27406597	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr10:27406597C>G	ENST00000326799.3	-	16	1946	c.1798G>C	c.(1798-1800)Gaa>Caa	p.E600Q	YME1L1_ENST00000376016.3_Missense_Mutation_p.E543Q|YME1L1_ENST00000375972.3_Missense_Mutation_p.E510Q	NM_139312.2	NP_647473.1	Q96TA2	YMEL1_HUMAN	YME1-like 1 ATPase	600					protein catabolic process|proteolysis	membrane|mitochondrion	ATP binding|metal ion binding|metalloendopeptidase activity|nucleoside-triphosphatase activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	23						TGACCAGATTCATGATATGCT	0.363000													56	122					0	0	1	0	0
APC	324	broad.mit.edu	37	5	112102988	112102988	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr5:112102988G>C	ENST00000457016.1	+	4	703	c.323G>C	c.(322-324)gGa>gCa	p.G108A	APC_ENST00000508376.2_Missense_Mutation_p.G108A|APC_ENST00000257430.4_Missense_Mutation_p.G108A			P25054	APC_HUMAN	adenomatous polyposis coli	108	Leu-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity			NS(7)|adrenal_gland(6)|biliary_tract(5)|bone(6)|breast(29)|central_nervous_system(12)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(2768)|liver(15)|lung(39)|oesophagus(1)|ovary(12)|pancreas(27)|prostate(15)|salivary_gland(2)|skin(14)|small_intestine(34)|soft_tissue(55)|stomach(136)|thyroid(22)|upper_aerodigestive_tract(8)|urinary_tract(20)	3261		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		AGCCGTTCTGGAGAGTGCAGT	0.433000		12	"""D, Mis, N, F, S"""		"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""	"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""			Turcot syndrome;Hereditary Desmoid Disease;Familial Adenomatous Polyposis	TSP Lung(16;0.13)			62	93					0	0	1	0	0
TEKT2	27285	broad.mit.edu	37	1	36550832	36550832	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:36550832G>A	ENST00000207457.3	+	3	352	c.225G>A	c.(223-225)aaG>aaA	p.K75K		NM_014466.2	NP_055281.2	Q9UIF3	TEKT2_HUMAN	tektin 2 (testicular)	75					cell projection organization|microtubule cytoskeleton organization	actin cytoskeleton|cilium axoneme|flagellar axoneme|focal adhesion|microtubule|nucleolus				breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(2)|pancreas(1)|skin(2)	13		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				ACCGGTGGAAGGAGATGCTGG	0.552000													32	49					0	0	1	0	0
LRRC37A4P	55073	broad.mit.edu	37	17	43592074	43592074	+	RNA	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr17:43592074C>T	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							TTTGCACTTTCTAAAATGGAA	0.453000													17	196					0	0	1	0	0
PLCZ1	89869	broad.mit.edu	37	12	18876447	18876447	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr12:18876447G>A	ENST00000266505.7	-	4	428	c.165C>T	c.(163-165)atC>atT	p.I55I	PLCZ1_ENST00000435379.1_Intron|RP11-361I14.2_ENST00000536931.1_RNA|PLCZ1_ENST00000447925.2_Silent_p.I53I|PLCZ1_ENST00000539875.1_Intron			Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	55	EF-hand.				intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	31	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					CTTCTATGGTGATTCTTCCTT	0.308000													20	61					0	0	1	0	0
MC5R	4161	broad.mit.edu	37	18	13826052	13826052	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr18:13826052C>T	ENST00000324750.3	+	1	510	c.288C>T	c.(286-288)atC>atT	p.I96I		NM_005913.2	NP_005904.1	P33032	MC5R_HUMAN	melanocortin 5 receptor	96					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|upper_aerodigestive_tract(1)	41						CCATCACCATCTACCTACTCA	0.522000													32	67					0	0	1	0	0
MED16	10025	broad.mit.edu	37	19	884913	884913	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:884913G>A	ENST00000312090.6	-	6	1125	c.975C>T	c.(973-975)atC>atT	p.I325I	MED16_ENST00000589119.1_Silent_p.I325I|MED16_ENST00000395808.3_Silent_p.I325I|MED16_ENST00000325464.1_Silent_p.I325I|MED16_ENST00000269814.4_Silent_p.I325I|MED16_ENST00000606828.1_Intron			Q9Y2X0	MED16_HUMAN	mediator complex subunit 16	325					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	receptor activity|thyroid hormone receptor binding|thyroid hormone receptor coactivator activity|vitamin D receptor binding			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	21		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCACGGGGGAGATCTGCTGGA	0.642000													11	16					0	0	1	0	0
NPAS2	4862	broad.mit.edu	37	2	101606888	101606888	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:101606888C>T	ENST00000335681.5	+	18	2283	c.1998C>T	c.(1996-1998)ttC>ttT	p.F666F	NPAS2_ENST00000542504.1_Silent_p.F731F	NM_002518.3	NP_002509.2	Q99743	NPAS2_HUMAN	neuronal PAS domain protein 2	666					central nervous system development|positive regulation of transcription from RNA polymerase II promoter|rhythmic process	transcription factor complex	DNA binding|Hsp90 protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			cervix(1)|endometrium(3)|large_intestine(7)|lung(9)|ovary(3)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						GCCCAGACTTCAGCCATGATC	0.552000													26	47					0	0	1	0	0
RB1	5925	broad.mit.edu	37	13	48954210	48954210	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr13:48954210C>T	ENST00000267163.4	+	15	1549	c.1411C>T	c.(1411-1413)Caa>Taa	p.Q471*		NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1	471	Domain A.|Pocket; binds T and E1A.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(8)|p.Q471*(1)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ATTATCCATTCAAAATTTTAG	0.199000		6	"""D, Mis, N, F, S"""		"""retinoblastoma, sarcoma, breast, small cell lung"""	"""retinoblastoma, sarcoma, breast, small cell lung"""			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			14	27					0	0	1	0	0
RNF39	80352	broad.mit.edu	37	6	30040942	30040942	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr6:30040942C>T	ENST00000244360.6	-	3	771	c.674G>A	c.(673-675)aGa>aAa	p.R225K	RNF39_ENST00000376751.3_Missense_Mutation_p.R225K	NM_025236.3	NP_079512.2	Q9H2S5	RNF39_HUMAN	ring finger protein 39	225	B30.2/SPRY.					cytoplasm	zinc ion binding										ACCTGTCAGTCTATGAAGCAT	0.398000													52	81					0	0	1	0	0
GCN1L1	10985	broad.mit.edu	37	12	120587840	120587840	+	Silent	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr12:120587840G>C	ENST00000300648.6	-	35	4329	c.4317C>G	c.(4315-4317)ctC>ctG	p.L1439L		NM_006836.1	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	1439					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CGAAGGCAAAGAGGGCTCCTA	0.577000													8	47					0	0	1	0	0
TLR3	7098	broad.mit.edu	37	4	186997957	186997957	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr4:186997957C>G	ENST00000296795.3	+	2	288	c.184C>G	c.(184-186)Caa>Gaa	p.Q62E		NM_003265.2	NP_003256.1	O15455	TLR3_HUMAN	toll-like receptor 3						activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(5)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	29		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		TACCCATAATCAACTCAGAAG	0.453000													24	74					0	0	1	0	0
MAP4	4134	broad.mit.edu	37	3	47951694	47951694	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:47951694G>A	ENST00000426837.2	-	10	4355	c.4268C>T	c.(4267-4269)gCc>gTc	p.A1423V	MAP4_ENST00000264724.11_Missense_Mutation_p.A13V|MAP4_ENST00000395734.3_Intron|MAP4_ENST00000383737.4_Intron|MAP4_ENST00000360240.6_Intron			P27816	MAP4_HUMAN	microtubule-associated protein 4	808					negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(2)|pancreas(1)|skin(2)	32				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		GTCCATATAGGCCATTCCTTC	0.408000													26	49					0	0	1	0	0
ZC3H12D	340152	broad.mit.edu	37	6	149795653	149795653	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr6:149795653G>A	ENST00000389942.5	-	2	274	c.27C>T	c.(25-27)ttC>ttT	p.F9F	ZC3H12D_ENST00000409806.3_Silent_p.F9F|ZC3H12D_ENST00000416573.2_Silent_p.F9F|ZC3H12D_ENST00000409948.1_Silent_p.F9F|ZC3H12D_ENST00000542614.1_Silent_p.F9F			A2A288	ZC12D_HUMAN	zinc finger CCCH-type containing 12D	9						cytoplasm|nucleus	endonuclease activity|nucleic acid binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|prostate(1)	6		Ovarian(120;0.0907)		OV - Ovarian serous cystadenocarcinoma(155;1.23e-11)|GBM - Glioblastoma multiforme(68;0.0921)		GCTTCTGGAAGAATTCCATCT	0.632000													10	17					0	0	1	0	0
CFTR	1080	broad.mit.edu	37	7	117282538	117282538	+	Missense_Mutation	SNP	C	C	T	rs76649725		TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr7:117282538C>T	ENST00000003084.6	+	23	3896	c.3764C>T	c.(3763-3765)tCa>tTa	p.S1255L	AC000111.6_ENST00000456270.1_RNA|CFTR_ENST00000454343.1_Missense_Mutation_p.S1194L	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	1255	ABC transporter 2.		S -> P (in CF).		respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding	p.S1255*(1)		NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	ACTTTGTTATCAGCTTTTTTG	0.433000									Cystic Fibrosis				37	70					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36898549	36898549	+	Silent	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:36898549G>C	ENST00000429976.2	-	12	2779	c.2532C>G	c.(2530-2532)ctC>ctG	p.L844L	TRANK1_ENST00000428977.2_Silent_p.L294L|TRANK1_ENST00000301807.6_Silent_p.L294L	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	844					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						TAGCTTCGAAGAGCTGGATGC	0.547000													39	55					0	0	1	0	0
IGKV1-16	28938	broad.mit.edu	37	2	89399437	89399437	+	RNA	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:89399437G>A	ENST00000479981.1	-	0	292																											ATCTGTCCCAGATCCACTGCC	0.493000													152	278					0	0	1	0	0
HTATSF1	27336	broad.mit.edu	37	X	135593382	135593382	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chrX:135593382G>A	ENST00000535601.1	+	10	1900	c.1478G>A	c.(1477-1479)gGa>gAa	p.G493E	HTATSF1_ENST00000218364.4_Missense_Mutation_p.G493E	NM_001163280.1	NP_001156752.1	O43719	HTSF1_HUMAN	HIV-1 Tat specific factor 1	493	Asp/Glu-rich (acidic).|Mediates interaction with the P-TEFb complex.				regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|viral genome replication	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|biliary_tract(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(14)|ovary(3)|prostate(1)	30	Acute lymphoblastic leukemia(192;0.000127)					CCCGTAAGAGGATCTGAAGAG	0.443000													50	13					0	0	1	0	0
ATAD2	29028	broad.mit.edu	37	8	124408588	124408588	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr8:124408588G>A	ENST00000287394.5	-	1	117	c.10C>T	c.(10-12)Ctc>Ttc	p.L4F	ATAD2_ENST00000521903.1_Intron	NM_014109.3	NP_054828.2	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	4					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|lung(16)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	48	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			CTGCTGCGGAGAACCACCATC	0.652000													8	23					0	0	1	0	0
EPB41L2	2037	broad.mit.edu	37	6	131191231	131191231	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr6:131191231C>G	ENST00000337057.3	-	15	2260	c.2079G>C	c.(2077-2079)aaG>aaC	p.K693N	EPB41L2_ENST00000392427.3_Intron|EPB41L2_ENST00000530481.1_Missense_Mutation_p.K623N|EPB41L2_ENST00000445890.2_Intron|EPB41L2_ENST00000531410.1_Intron|EPB41L2_ENST00000524581.1_Missense_Mutation_p.K71N|EPB41L2_ENST00000529208.1_Missense_Mutation_p.K623N|EPB41L2_ENST00000530757.1_Intron|EPB41L2_ENST00000525271.1_Intron|EPB41L2_ENST00000528282.1_Intron|EPB41L2_ENST00000368128.2_Missense_Mutation_p.K693N|EPB41L2_ENST00000527659.1_Missense_Mutation_p.K623N|EPB41L2_ENST00000527411.1_Missense_Mutation_p.K623N|EPB41L2_ENST00000525193.1_Intron	NM_001431.3	NP_001422.1	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	693					cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(23)|prostate(1)|skin(2)	44	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		CTGCCCGCTTCTTCTCCTCCA	0.408000													34	81					0	0	1	0	0
FN1	2335	broad.mit.edu	37	2	216257848	216257848	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:216257848G>C	ENST00000354785.4	-	25	4244	c.3875C>G	c.(3874-3876)tCt>tGt	p.S1292C	FN1_ENST00000446046.1_Intron|FN1_ENST00000443816.1_Intron|FN1_ENST00000356005.4_Intron|FN1_ENST00000432072.2_Missense_Mutation_p.S1292C|FN1_ENST00000336916.4_Intron|FN1_ENST00000359671.1_Intron|FN1_ENST00000346544.3_Intron|FN1_ENST00000357009.2_Intron|FN1_ENST00000421182.1_Intron|FN1_ENST00000345488.5_Intron|FN1_ENST00000357867.4_Intron|FN1_ENST00000323926.6_Missense_Mutation_p.S1292C			P02751	FINC_HUMAN	fibronectin 1	1292	Cell-attachment.|Fibronectin type-III 8.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding		FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AATGGTGGAAGAGTTTAGCGG	0.468000													43	27					0	0	1	0	0
B4GALNT2	124872	broad.mit.edu	37	17	47246118	47246118	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr17:47246118C>T	ENST00000300404.2	+	10	1410	c.1351C>T	c.(1351-1353)Cac>Tac	p.H451Y	B4GALNT2_ENST00000393354.2_Missense_Mutation_p.H391Y|B4GALNT2_ENST00000504681.1_Missense_Mutation_p.H365Y	NM_153446.2	NP_703147.2	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	451					lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			endometrium(3)|large_intestine(6)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	24			all cancers(6;0.000316)			GGCCTGCCTTCACAAGAGGAT	0.557000													29	34					0	0	1	0	0
MYLK3	91807	broad.mit.edu	37	16	46746605	46746605	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr16:46746605G>A	ENST00000394809.4	-	10	2184	c.2069C>T	c.(2068-2070)tCa>tTa	p.S690L	MYLK3_ENST00000536476.1_Missense_Mutation_p.S349L	NM_182493.2	NP_872299.2	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	690	Protein kinase.				cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(3)|prostate(3)|skin(5)|stomach(3)	37		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				TGTGGGGAATGAGACAAACTC	0.537000													26	84					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31324989	31324989	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr18:31324989C>G	ENST00000269197.5	+	12	5177	c.5177C>G	c.(5176-5178)gCc>gGc	p.A1726G		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1726					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						GCTACCGATGCCCTGAAGAGA	0.557000													35	56					0	0	1	0	0
C14orf159	80017	broad.mit.edu	37	14	91655351	91655351	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr14:91655351C>T	ENST00000518868.1	+	12	1722	c.1032C>T	c.(1030-1032)ttC>ttT	p.F344F	C14orf159_ENST00000522322.1_Silent_p.F339F|C14orf159_ENST00000523771.1_Silent_p.F339F|C14orf159_ENST00000520328.1_Silent_p.F327F|C14orf159_ENST00000523816.1_Silent_p.F339F|C14orf159_ENST00000428926.2_Silent_p.F339F|C14orf159_ENST00000256324.10_Silent_p.F344F|C14orf159_ENST00000521077.2_Silent_p.F344F|C14orf159_ENST00000525393.2_Silent_p.F215F|C14orf159_ENST00000412671.2_Silent_p.F344F			Q7Z3D6	CN159_HUMAN	chromosome 14 open reading frame 159	339						mitochondrion				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	21		all_cancers(154;0.0191)|all_epithelial(191;0.241)		Epithelial(152;0.141)|OV - Ovarian serous cystadenocarcinoma(161;0.207)		CCACTGGGTTCCCCACACATT	0.587000													36	45					0	0	1	0	0
TUBBP1	92755	broad.mit.edu	37	8	30210560	30210560	+	RNA	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr8:30210560C>T	ENST00000518096.1	+	0	1172																											GAATGGATCCCCAACAATATC	0.527000													48	46					0	0	1	0	0
LUZP2	338645	broad.mit.edu	37	11	24759795	24759795	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr11:24759795C>T	ENST00000533227.1	+	4	309	c.22C>T	c.(22-24)Ctg>Ttg	p.L8L	LUZP2_ENST00000531187.1_3'UTR|LUZP2_ENST00000336930.6_Silent_p.L94L	NM_001009909.3|NM_001252008.1	NP_001009909.2|NP_001238937.1	Q86TE4	LUZP2_HUMAN	leucine zipper protein 2	94						extracellular region				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(11)|lung(12)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	32						TCAGGAGGCCCTGCAAAATCA	0.358000													38	63					0	0	1	0	0
TRAV5	28688	broad.mit.edu	37	14	22217932	22217932	+	RNA	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr14:22217932C>T	ENST00000390427.3	+	0	295																											ACATCTGTCTCTGCGCATTGC	0.438000													40	77					0	0	1	0	0
PLEKHG2	64857	broad.mit.edu	37	19	39914197	39914197	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:39914197G>A	ENST00000425673.1	+	16	2741	c.2416G>A	c.(2416-2418)Gag>Aag	p.E806K	PLEKHG2_ENST00000458508.2_Missense_Mutation_p.E776K|PLEKHG2_ENST00000409797.2_Intron|PLEKHG2_ENST00000378550.1_Intron|PLEKHG2_ENST00000409794.3_Missense_Mutation_p.E835K			Q9H7P9	PKHG2_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	835					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(2)|liver(1)|lung(13)|pancreas(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	40	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GCAGCGGGCGGAGACTCGGGC	0.697000													8	16					0	0	1	0	0
LRRC10	376132	broad.mit.edu	37	12	70004086	70004086	+	Missense_Mutation	SNP	C	C	T	rs138855649		TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr12:70004086C>T	ENST00000361484.3	-	1	856	c.533G>A	c.(532-534)cGg>cAg	p.R178Q		NM_201550.2	NP_963844.2	Q5BKY1	LRC10_HUMAN	leucine rich repeat containing 10	178						nucleus				large_intestine(2)|lung(6)	8	all_cancers(2;2.83e-105)|Breast(13;9.83e-07)|Esophageal squamous(21;0.187)		Epithelial(6;1.98e-18)|GBM - Glioblastoma multiforme(2;7.43e-12)|Lung(24;0.000185)|OV - Ovarian serous cystadenocarcinoma(12;0.00126)|STAD - Stomach adenocarcinoma(21;0.00501)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			GTCAGTTAGCCGGTTGCCCGA	0.612000													31	305					0	0	1	0	0
HDLBP	3069	broad.mit.edu	37	2	242186541	242186541	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:242186541G>A	ENST00000391975.1	-	15	1975	c.1748C>T	c.(1747-1749)tCa>tTa	p.S583L	HDLBP_ENST00000310931.4_Missense_Mutation_p.S583L|HDLBP_ENST00000427183.2_Missense_Mutation_p.S550L|HDLBP_ENST00000391976.2_Missense_Mutation_p.S583L	NM_203346.3	NP_976221	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	583	KH 6.				cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(7)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(11)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		AACAGAAATTGAATAGCTATT	0.408000													24	13					0	0	1	0	0
SLC10A2	6555	broad.mit.edu	37	13	103701709	103701709	+	Silent	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr13:103701709G>C	ENST00000245312.3	-	5	1445	c.849C>G	c.(847-849)ctC>ctG	p.L283L		NM_000452.2	NP_000443	Q12908	NTCP2_HUMAN	solute carrier family 10 (sodium/bile acid cotransporter), member 2	283					bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_neural(89;0.0662)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					ATACGACATTGAGCTCCTCAG	0.478000													42	116					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55534023	55534023	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr8:55534023C>T	ENST00000220676.1	+	2	645	c.497C>T	c.(496-498)aCg>aTg	p.T166M		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	166	Doublecortin 2.				axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding	p.T166M(1)		NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GACCCGAAGACGAGGCGTGCG	0.642000													74	106					0	0	1	0	0
PSD3	23362	broad.mit.edu	37	8	18730069	18730069	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr8:18730069G>C	ENST00000440756.2	-	3	407	c.305C>G	c.(304-306)tCt>tGt	p.S102C	PSD3_ENST00000327040.8_Missense_Mutation_p.S102C|PSD3_ENST00000523619.1_Missense_Mutation_p.S37C			Q9NYI0	PSD3_HUMAN	pleckstrin and Sec7 domain containing 3	102					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		GTCGAGCCCAGAGTGGCAGCC	0.522000													49	42					0	0	1	0	0
RPAP3	79657	broad.mit.edu	37	12	48084423	48084423	+	Splice_Site	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr12:48084423C>G	ENST00000005386.3	-	6	661		c.e6-1		RPAP3_ENST00000380650.4_Splice_Site|RPAP3_ENST00000432584.3_Splice_Site	NM_024604.2	NP_078880.2	Q9H6T3	RPAP3_HUMAN	RNA polymerase II associated protein 3								binding			endometrium(2)|large_intestine(4)|liver(1)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16	Lung SC(27;0.192)					AACAGCAAATCTGCaatttaa	0.299000													94	163					0	0	1	0	0
LINC00264	645528	broad.mit.edu	37	10	26880266	26880266	+	RNA	SNP	G	G	A	rs138111133	by1000genomes	TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr10:26880266G>A	ENST00000412114.1	+	0	501					NR_026793.1																						ACCAAGCCCAGTGGACAGATG	0.443000													4	80					0	0	1	0	0
KDM3B	51780	broad.mit.edu	37	5	137727353	137727353	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr5:137727353C>T	ENST00000314358.5	+	8	2232	c.2032C>T	c.(2032-2034)Cac>Tac	p.H678Y	KDM3B_ENST00000394866.1_Missense_Mutation_p.H334Y|KDM3B_ENST00000542866.1_Intron	NM_016604.3	NP_057688	Q7LBC6	KDM3B_HUMAN	lysine (K)-specific demethylase 3B	678	Ser-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(15)|liver(2)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	65						GCCCGAGTCTCACTCCTCTGC	0.512000													51	97					0	0	1	0	0
PKDREJ	10343	broad.mit.edu	37	22	46652706	46652706	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr22:46652706G>A	ENST00000253255.5	-	1	6513	c.6514C>T	c.(6514-6516)Ctg>Ttg	p.L2172L		NM_006071.1	NP_006062.1	Q9NTG1	PKDRE_HUMAN	polycystin (PKD) family receptor for egg jelly	2172					acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			NS(2)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(4)|kidney(5)|large_intestine(21)|lung(16)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	73		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		TATGCAGACAGAATTACAGCC	0.453000													51	36					0	0	1	0	0
IFNK	56832	broad.mit.edu	37	9	27524545	27524545	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr9:27524545G>A	ENST00000276943.2	+	1	234	c.211G>A	c.(211-213)Gag>Aag	p.E71K	MOB3B_ENST00000262244.5_Intron	NM_020124.2	NP_064509.2	Q9P0W0	IFNK_HUMAN	interferon, kappa	71					cytokine-mediated signaling pathway|defense response|natural killer cell activation|negative regulation of cell proliferation|positive regulation of innate immune response|regulation of transcription, DNA-dependent|response to virus	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			large_intestine(1)	1		all_neural(11;7.9e-11)		LUSC - Lung squamous cell carcinoma(38;0.0001)|Lung(218;0.000158)		GTTGCCCCAAGAGTTTCTGCA	0.433000													56	100					0	0	1	0	0
E2F2	1870	broad.mit.edu	37	1	23847564	23847564	+	Splice_Site	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:23847564C>T	ENST00000361729.2	-	4	1005		c.e4-1			NM_004091.3	NP_004082.1	Q14209	E2F2_HUMAN	E2F transcription factor 2						G1 phase of mitotic cell cycle|transcription initiation from RNA polymerase II promoter	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			endometrium(4)|large_intestine(2)|lung(1)|ovary(3)|skin(2)|urinary_tract(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.52e-24)|Colorectal(126;6.25e-08)|COAD - Colon adenocarcinoma(152;3.42e-06)|GBM - Glioblastoma multiforme(114;8.98e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00102)|KIRC - Kidney renal clear cell carcinoma(1967;0.00366)|STAD - Stomach adenocarcinoma(196;0.0132)|READ - Rectum adenocarcinoma(331;0.0652)|Lung(427;0.0888)|LUSC - Lung squamous cell carcinoma(448;0.19)		TCCCCTGCCTCTGGGAACAGA	0.552000													7	31					0	0	1	0	0
RASGEF1C	255426	broad.mit.edu	37	5	179555520	179555520	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr5:179555520C>A	ENST00000393371.2	-	4	825	c.529G>T	c.(529-531)Gac>Tac	p.D177Y	RASGEF1C_ENST00000522500.1_Missense_Mutation_p.D26Y|RASGEF1C_ENST00000361132.4_Missense_Mutation_p.D177Y|RASGEF1C_ENST00000519883.1_5'UTR			Q8N431	RGF1C_HUMAN	RasGEF domain family, member 1C	177					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity			breast(1)|kidney(2)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)|stomach(1)	12	all_cancers(89;3.44e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	all_cancers(40;0.0242)|Medulloblastoma(196;0.00498)|all_neural(177;0.0137)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ATGGGCTTGTCGGCACCCACC	0.637000													25	42					4.72057e-08	4.77702e-08	1	1	0
PZP	5858	broad.mit.edu	37	12	9313684	9313684	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr12:9313684C>G	ENST00000261336.2	-	23	2845	c.2817G>C	c.(2815-2817)ttG>ttC	p.L939F	PZP_ENST00000381997.2_Missense_Mutation_p.L725F|PZP_ENST00000539983.1_5'UTR	NM_002864.2	NP_002855.2			pregnancy-zone protein											breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(21)|lung(46)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)	102						ATGGGAGCTTCAAGGACAACT	0.408000													50	108					0	0	1	0	0
TET3	200424	broad.mit.edu	37	2	74274067	74274067	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:74274067G>C	ENST00000409262.3	+	1	618	c.618G>C	c.(616-618)caG>caC	p.Q206H		NM_144993.1	NP_659430.1	O43151	TET3_HUMAN	tet methylcytosine dioxygenase 3	206							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						CCCTGTCCCAGAGTGCCCTGA	0.627000													22	35					0	0	1	0	0
IBTK	25998	broad.mit.edu	37	6	82924503	82924503	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr6:82924503C>G	ENST00000306270.7	-	12	2194	c.1645G>C	c.(1645-1647)Gag>Cag	p.E549Q	IBTK_ENST00000503631.1_Intron|IBTK_ENST00000510291.1_Missense_Mutation_p.E549Q	NM_015525.2	NP_056340.2	Q9P2D0	IBTK_HUMAN	inhibitor of Bruton agammaglobulinemia tyrosine kinase	549					negative regulation of protein phosphorylation|release of sequestered calcium ion into cytosol	cytoplasm|membrane|nucleus	protein kinase binding|protein tyrosine kinase inhibitor activity			central_nervous_system(2)|endometrium(9)|kidney(3)|large_intestine(10)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	54		all_cancers(76;3.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.0037)		BRCA - Breast invasive adenocarcinoma(397;0.0901)		TTGCCAAACTCTTCAAAAAAG	0.348000													43	84					0	0	1	0	0
QSOX1	5768	broad.mit.edu	37	1	180166064	180166064	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:180166064C>T	ENST00000367602.3	+	12	2210	c.2136C>T	c.(2134-2136)ctC>ctT	p.L712L	QSOX1_ENST00000367600.5_Intron			O00391	QSOX1_HUMAN	quiescin Q6 sulfhydryl oxidase 1	712					cell redox homeostasis|protein thiol-disulfide exchange	extracellular space|integral to Golgi membrane	flavin-linked sulfhydryl oxidase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(9)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	31						ACATCAGCCTCTGTGTGGGGC	0.642000													46	30					0	0	1	0	0
ELF3	1999	broad.mit.edu	37	1	201982361	201982361	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:201982361G>A	ENST00000359651.3	+	6	3932	c.740G>A	c.(739-741)cGa>cAa	p.R247Q	ELF3_ENST00000367283.3_Missense_Mutation_p.R247Q|ELF3_ENST00000367284.5_Missense_Mutation_p.R247Q|RP11-510N19.5_ENST00000504773.1_RNA			P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription factor, epithelial-specific )	247					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	20						AAGCGGAAACGAGGCCGGCCC	0.627000													40	53					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215848734	215848734	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:215848734C>T	ENST00000366943.2	-	63	12905	c.12519G>A	c.(12517-12519)ctG>ctA	p.L4173L	USH2A_ENST00000307340.3_Silent_p.L4173L			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	4173	Fibronectin type-III 27.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CAGACCAGCTCAGCTCAACAC	0.522000										HNSCC(13;0.011)			18	93					0	0	1	0	0
GOLGA3	2802	broad.mit.edu	37	12	133381425	133381425	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr12:133381425C>T	ENST00000204726.3	-	7	2032	c.1474G>A	c.(1474-1476)Gag>Aag	p.E492K	GOLGA3_ENST00000450791.2_Missense_Mutation_p.E492K|GOLGA3_ENST00000545875.1_Missense_Mutation_p.E492K|GOLGA3_ENST00000456883.2_Missense_Mutation_p.E492K|GOLGA3_ENST00000537452.1_Missense_Mutation_p.E492K	NM_005895.3	NP_005886.2	Q08378	GOGA3_HUMAN	golgin A3	492					intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		TTTTTTGCCTCCAGCATGTTC	0.602000													18	64					0	0	1	0	0
USP28	57646	broad.mit.edu	37	11	113711320	113711320	+	Splice_Site	SNP	C	C	T	rs34802473		TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr11:113711320C>T	ENST00000003302.4	-	5	602	c.534G>A	c.(532-534)caG>caA	p.Q178Q	USP28_ENST00000542033.1_5'UTR|USP28_ENST00000537706.1_Splice_Site_p.Q178Q|USP28_ENST00000545540.1_Splice_Site_p.Q53Q|USP28_ENST00000260188.5_Splice_Site_p.Q178Q	NM_020886.2	NP_065937.1	Q96RU2	UBP28_HUMAN	ubiquitin specific peptidase 28	178					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(24)|ovary(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	59		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		AATATCATACCTGAATAACAG	0.348000													29	23					0	0	1	0	0
OR10AG1	282770	broad.mit.edu	37	11	55735289	55735289	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr11:55735289C>T	ENST00000312345.2	-	1	701	c.651G>A	c.(649-651)ttG>ttA	p.L217L		NM_001005491.1	NP_001005491.1	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG, member 1	217					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(24)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	40	Esophageal squamous(21;0.0137)					ATGACAATTTCAAAATGTTGG	0.393000													31	57					0	0	1	0	0
TMEM164	84187	broad.mit.edu	37	X	109416667	109416667	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chrX:109416667G>C	ENST00000372073.1	+	7	1218	c.882G>C	c.(880-882)aaG>aaC	p.K294N	TMEM164_ENST00000372072.3_Missense_Mutation_p.K145N|TMEM164_ENST00000288381.4_Missense_Mutation_p.K255N|TMEM164_ENST00000464177.1_3'UTR|TMEM164_ENST00000372068.2_Missense_Mutation_p.K294N			Q5U3C3	TM164_HUMAN	transmembrane protein 164	294						integral to membrane				cervix(1)|endometrium(1)|large_intestine(5)|lung(6)|skin(1)	14						TTCCAGCCAAGAAAATAGACT	0.458000													39	13					0	0	1	0	0
MTMR4	9110	broad.mit.edu	37	17	56572730	56572730	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr17:56572730G>A	ENST00000323456.5	-	16	2897	c.2773C>T	c.(2773-2775)Cgg>Tgg	p.R925W	MTMR4_ENST00000579925.1_Missense_Mutation_p.R868W	NM_004687.4	NP_004678.3	Q9NYA4	MTMR4_HUMAN	myotubularin related protein 4	925						cytoplasm|membrane	metal ion binding|protein tyrosine phosphatase activity			breast(10)|endometrium(2)|kidney(2)|large_intestine(5)|lung(12)|skin(5)	36	Medulloblastoma(34;0.127)|all_neural(34;0.237)					AGCAGCCGCCGAGGGGTGGCC	0.567000													47	91					0	0	1	0	0
ATP8B2	57198	broad.mit.edu	37	1	154317616	154317616	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:154317616T>C	ENST00000368489.3	+	22	2555	c.2555T>C	c.(2554-2556)gTc>gCc	p.V852A		NM_020452.3	NP_065185.1	P98198	AT8B2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 2	838					ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity		IL6R/ATP8B2(2)	breast(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			GCCAATGATGTCAGCATGATC	0.572000											OREG0013835	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	151	75					0	0	1	0	0
ABHD14A-ACY1	100526760	broad.mit.edu	37	3	52011891	52011891	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:52011891T>C	ENST00000463937.1	+	2	150	c.74T>C	c.(73-75)gTg>gCg	p.V25A	ACY1_ENST00000458031.2_5'UTR|ABHD14B_ENST00000483233.1_Intron|ABHD14A_ENST00000491470.1_Missense_Mutation_p.V25A|ABHD14A_ENST00000273596.3_Missense_Mutation_p.V25A																							CTCCAGACTGTGGTACAGACC	0.617000													72	115					0	0	1	0	0
KCNK10	54207	broad.mit.edu	37	14	88658696	88658696	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr14:88658696G>A	ENST00000340700.5	-	5	1176	c.725C>T	c.(724-726)gCc>gTc	p.A242V	KCNK10_ENST00000319231.5_Missense_Mutation_p.A247V|KCNK10_ENST00000312350.5_Missense_Mutation_p.A247V	NM_021161.4	NP_066984.1	P57789	KCNKA_HUMAN	potassium channel, subfamily K, member 10	242					signal transduction	integral to membrane	potassium channel activity|voltage-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(3)|pancreas(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	47						AATGCAGCCGGCCAAGATGAA	0.502000													4	123					0	0	1	0	0
RBL2	5934	broad.mit.edu	37	16	53495763	53495763	+	Splice_Site	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr16:53495763G>A	ENST00000262133.6	+	10	1593		c.e10+1		RBL2_ENST00000544545.1_Splice_Site|RBL2_ENST00000379935.4_Splice_Site	NM_005611.3	NP_005602.3	Q08999	RBL2_HUMAN	retinoblastoma-like 2 (p130)						cell cycle|chromatin modification|regulation of cell cycle|regulation of lipid kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(17)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45						TGTGCTAAAGGTAAGGTTTAA	0.328000													26	13					0	0	1	0	0
FARSA	2193	broad.mit.edu	37	19	13035075	13035075	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:13035075C>T	ENST00000588025.1	-	13	1538	c.1398G>A	c.(1396-1398)ctG>ctA	p.L466L	FARSA_ENST00000423140.2_Silent_p.L395L|FARSA_ENST00000314606.4_Silent_p.L426L			Q9Y285	SYFA_HUMAN	phenylalanyl-tRNA synthetase, alpha subunit	426					phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|phenylalanine-tRNA ligase activity|protein binding|tRNA binding			NS(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(9)|ovary(3)|upper_aerodigestive_tract(1)	20					L-Phenylalanine(DB00120)	CCCACTTCTTCAGGCCTGCAG	0.607000													32	90					0	0	1	0	0
CD209	30835	broad.mit.edu	37	19	7810547	7810547	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:7810547G>A	ENST00000315599.7	-	4	627	c.605C>T	c.(604-606)gCa>gTa	p.A202V	CD209_ENST00000394173.4_Intron|CD209_ENST00000601951.1_Missense_Mutation_p.A178V|CD209_ENST00000394161.5_Intron|CD209_ENST00000354397.6_Missense_Mutation_p.A202V|CD209_ENST00000593660.1_Missense_Mutation_p.A178V|CD209_ENST00000204801.8_Missense_Mutation_p.A158V|CD209_ENST00000315591.8_Missense_Mutation_p.A178V|CD209_ENST00000593821.1_Intron|CD209_ENST00000601256.1_Missense_Mutation_p.A178V|CD209_ENST00000602261.1_Intron|CD209_ENST00000301357.8_Intron	NM_001144895.1|NM_001144897.1|NM_021155.3	NP_001138367.1|NP_001138369.1|NP_066978.1	Q9NNX6	CD209_HUMAN	CD209 molecule	202	7 X approximate tandem repeats.				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding			endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						CTCACCCACTGCAGCCTTCAG	0.557000													15	187					0	0	1	0	0
ASTL	431705	broad.mit.edu	37	2	96799204	96799204	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:96799204G>A	ENST00000342380.2	-	5	414	c.415C>T	c.(415-417)Cag>Tag	p.Q139*		NM_001002036.3	NP_001002036.3	Q6HA08	ASTL_HUMAN	astacin-like metallo-endopeptidase (M12 family)	139					proteolysis		metalloendopeptidase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(1)|prostate(1)|skin(2)	30						CTCTGGTCCTGATAGGTGACA	0.557000													40	91					0	0	1	0	0
ITGA11	22801	broad.mit.edu	37	15	68649536	68649536	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr15:68649536C>T	ENST00000423218.2	-	7	797	c.702G>A	c.(700-702)caG>caA	p.Q234Q	ITGA11_ENST00000562826.1_5'UTR|ITGA11_ENST00000315757.7_Silent_p.Q234Q			Q9UKX5	ITA11_HUMAN	integrin, alpha 11	234	VWFA.				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(6)|lung(22)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	52					Tirofiban(DB00775)	TTCCTCCTCTCTGCTCAATGT	0.428000													23	41					0	0	1	0	0
RPTN	126638	broad.mit.edu	37	1	152128575	152128575	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:152128575G>A	ENST00000316073.3	-	3	1064	c.1000C>T	c.(1000-1002)Cca>Tca	p.P334S		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	334	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding			breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						TGTCTGTCTGGCTGACTGTAG	0.483000													7	1360					0	0	1	0	0
JAKMIP2	9832	broad.mit.edu	37	5	146997502	146997502	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr5:146997502C>G	ENST00000265272.5	-	19	2785	c.2318G>C	c.(2317-2319)aGa>aCa	p.R773T	JAKMIP2_ENST00000333010.6_Missense_Mutation_p.R731T|JAKMIP2_ENST00000507386.1_Missense_Mutation_p.R752T	NM_001270941.1|NM_014790.4	NP_001257870.1|NP_055605.2	Q96AA8	JKIP2_HUMAN	janus kinase and microtubule interacting protein 2	773						Golgi apparatus				NS(1)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(22)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)	64			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGCTCCATTCTCTCCTGAAG	0.483000													41	48					0	0	1	0	0
CNNM4	26504	broad.mit.edu	37	2	97426942	97426942	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:97426942C>T	ENST00000377075.2	+	1	304	c.206C>T	c.(205-207)tCc>tTc	p.S69F		NM_020184.3	NP_064569.3	Q6P4Q7	CNNM4_HUMAN	cyclin M4	69					biomineral tissue development|ion transport|response to stimulus|visual perception	integral to membrane|plasma membrane				breast(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)	20						ATCTTCGTGTCCGAGGGCAGC	0.642000													13	48					0	0	1	0	0
CMSS1	84319	broad.mit.edu	37	3	99881159	99881159	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:99881159G>A	ENST00000421999.2	+	4	384	c.238G>A	c.(238-240)Gat>Aat	p.D80N	CMSS1_ENST00000489081.1_Missense_Mutation_p.D62N	NM_032359.3	NP_115735.2			cms1 ribosomal small subunit homolog (yeast)																		GAAAATTACTGATGTTCTTGC	0.373000													45	68					0	0	1	0	0
SLC12A6	9990	broad.mit.edu	37	15	34628825	34628825	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr15:34628825C>T	ENST00000354181.3	-	2	549	c.57G>A	c.(55-57)ccG>ccA	p.P19P	SLC12A6_ENST00000558589.1_Silent_p.P10P|SLC12A6_ENST00000397702.2_Intron|SLC12A6_ENST00000558667.1_Silent_p.P19P|SLC12A6_ENST00000560611.1_Silent_p.P19P|SLC12A6_ENST00000397707.2_Silent_p.P19P|SLC12A6_ENST00000458406.2_Intron			Q9UHW9	S12A6_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 6	19					angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(17)|ovary(4)|skin(3)	45		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)	CGATCTTTGTCGGTGTCACCA	0.488000													29	118					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179622549	179622549	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:179622549G>A	ENST00000589042.1	-	45	10622	c.10398C>T	c.(10396-10398)agC>agT	p.S3466S	TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342992.6_Intron|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000360870.5_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000591111.1_Intron|TTN_ENST00000359218.5_Silent_p.S3420S	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	3155							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTGGATGAAGCTGGGCTTTT	0.458000													77	94					0	0	1	0	0
DPP10	57628	broad.mit.edu	37	2	116066898	116066898	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:116066898C>T	ENST00000410059.1	+	2	624	c.144C>T	c.(142-144)ctC>ctT	p.L48L	DPP10_ENST00000310323.8_Silent_p.L41L|DPP10_ENST00000393147.2_Silent_p.L52L|DPP10_ENST00000409163.1_5'UTR	NM_001178037.1|NM_020868.3	NP_001171508.1|NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl-peptidase 10 (non-functional)	48	Mediates effects on KCND2.				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(24)|liver(2)|lung(48)|ovary(6)|prostate(1)|skin(5)|soft_tissue(1)	101						TATGCTCACTCATCACTATGT	0.413000													25	57					0	0	1	0	0
TANC2	26115	broad.mit.edu	37	17	61498587	61498587	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr17:61498587G>A	ENST00000424789.2	+	25	5248	c.5244G>A	c.(5242-5244)tcG>tcA	p.S1748S	TANC2_ENST00000389520.4_Silent_p.S1758S|RP11-269G24.3_ENST00000583552.1_RNA	NM_025185.3	NP_079461.2	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2	1748							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|upper_aerodigestive_tract(3)	44						CTGATGTGTCGCATTTAATCA	0.527000													4	263					0	0	1	0	0
FAM90A1	55138	broad.mit.edu	37	12	8374596	8374596	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr12:8374596G>C	ENST00000538603.1	-	7	1775	c.1217C>G	c.(1216-1218)tCc>tGc	p.S406C	FAM90A1_ENST00000307435.6_Missense_Mutation_p.S406C	NM_018088.3	NP_060558.3	Q86YD7	F90A1_HUMAN	family with sequence similarity 90, member A1	406							nucleic acid binding|zinc ion binding			endometrium(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	25				Kidney(36;0.0866)		CAGCAGGCTGGAGCTCCAGCG	0.622000													19	57					0	0	1	0	0
KDM7A	80853	broad.mit.edu	37	7	139801781	139801781	+	Silent	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr7:139801781G>C	ENST00000397560.2	-	12	1705	c.1608C>G	c.(1606-1608)ctC>ctG	p.L536L	JHDM1D_ENST00000006967.5_Silent_p.L536L	NM_030647.1	NP_085150.1	Q6ZMT4	KDM7_HUMAN		536					midbrain development|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			central_nervous_system(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)|stomach(1)	22	Melanoma(164;0.0142)					CTAATCTTTTGAGGACCTCCC	0.413000													69	167					0	0	1	0	0
GUCY2C	2984	broad.mit.edu	37	12	14804398	14804398	+	Silent	SNP	C	C	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr12:14804398C>A	ENST00000261170.3	-	15	1789	c.1653G>T	c.(1651-1653)gtG>gtT	p.V551V		NM_004963.3	NP_004954.2	P25092	GUC2C_HUMAN	guanylate cyclase 2C (heat stable enterotoxin receptor)	551	Protein kinase.				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						TATCAAGTTTCACTGTGCCGT	0.403000													39	86					1.47197e-15	1.52374e-15	1	1	0
TROVE2	6738	broad.mit.edu	37	1	193050546	193050546	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:193050546C>G	ENST00000432079.1	+	5	882	c.314C>G	c.(313-315)tCt>tGt	p.S105C	TROVE2_ENST00000400968.2_Missense_Mutation_p.S380C|TROVE2_ENST00000367446.3_Missense_Mutation_p.S380C|TROVE2_ENST00000416058.2_Missense_Mutation_p.S105C|TROVE2_ENST00000460715.2_3'UTR|TROVE2_ENST00000367443.1_Missense_Mutation_p.S380C|TROVE2_ENST00000367445.3_Missense_Mutation_p.S380C|TROVE2_ENST00000367441.1_Missense_Mutation_p.S380C|TROVE2_ENST00000367444.3_Missense_Mutation_p.S380C			P10155	RO60_HUMAN	TROVE domain family, member 2	380	TROVE.				transcription from RNA polymerase III promoter	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|RNA binding			biliary_tract(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(7)|prostate(2)|urinary_tract(1)	21						GTCAGTGCTTCTATGAACCAA	0.363000													47	54					0	0	1	0	0
SLC29A4	222962	broad.mit.edu	37	7	5336708	5336708	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr7:5336708G>A	ENST00000396872.3	+	7	922	c.761G>A	c.(760-762)cGc>cAc	p.R254H	SLC29A4_ENST00000406453.3_Missense_Mutation_p.R240H|SLC29A4_ENST00000297195.4_Missense_Mutation_p.R254H			Q7RTT9	S29A4_HUMAN	solute carrier family 29 (equilibrative nucleoside transporter), member 4						nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|integral to membrane	nucleoside transmembrane transporter activity			breast(1)|cervix(2)|kidney(7)|large_intestine(1)|liver(1)|lung(7)|urinary_tract(1)	20		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0903)|OV - Ovarian serous cystadenocarcinoma(56;2.65e-15)		TTAGTGCGGCGCAGCCGCTTC	0.662000													28	60					0	0	1	0	0
SKOR1	390598	broad.mit.edu	37	15	68126153	68126153	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr15:68126153C>G	ENST00000380035.2	+	9	2935	c.2877C>G	c.(2875-2877)ttC>ttG	p.F959L	SKOR1_ENST00000554054.1_Missense_Mutation_p.F931L|RP11-34F13.3_ENST00000558889.1_RNA|SKOR1_ENST00000341418.5_Missense_Mutation_p.F862L|SKOR1_ENST00000389002.1_Missense_Mutation_p.F915L|SKOR1_ENST00000554240.1_Missense_Mutation_p.F920L			P84550	SKOR1_HUMAN	SKI family transcriptional corepressor 1	959					negative regulation of BMP signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	cytoplasm|dendrite|neuronal cell body|nucleus	nucleotide binding|SMAD binding|transcription repressor activity			endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(7)|urinary_tract(1)	23						ACTGCTCCTTCAAGCCACCGC	0.657000											OREG0023216	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	65					0	0	1	0	0
EIF3K	27335	broad.mit.edu	37	19	39116716	39116716	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:39116716G>C	ENST00000545173.2	+	4	404	c.328G>C	c.(328-330)Gag>Cag	p.E110Q	EIF3K_ENST00000592558.1_Missense_Mutation_p.E110Q|EIF3K_ENST00000593062.1_3'UTR|EIF3K_ENST00000593149.1_Missense_Mutation_p.E23Q|EIF3K_ENST00000588934.1_Missense_Mutation_p.E110Q|EIF3K_ENST00000248342.4_Missense_Mutation_p.E110Q|EIF3K_ENST00000538434.1_Missense_Mutation_p.E23Q			Q9UBQ5	EIF3K_HUMAN	eukaryotic translation initiation factor 3, subunit K	110					regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex|nucleus	protein binding|ribosome binding|translation initiation factor activity		EIF3K/CYP39A1(2)	central_nervous_system(1)|endometrium(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	8	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GGACCTGCTGGAGACCTGCCA	0.567000													114	160					0	0	1	0	0
STXBP5	134957	broad.mit.edu	37	6	147636838	147636838	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr6:147636838C>T	ENST00000367481.3	+	15	1698	c.1590C>T	c.(1588-1590)ttC>ttT	p.F530F	STXBP5_ENST00000179882.6_Silent_p.F201F|STXBP5_ENST00000367480.3_Silent_p.F530F|STXBP5_ENST00000321680.6_Silent_p.F530F	NM_139244.4	NP_640337.3	Q5T5C0	STXB5_HUMAN	syntaxin binding protein 5 (tomosyn)	530					exocytosis|positive regulation of exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|nicotinic acetylcholine-gated receptor-channel complex|synaptic vesicle	syntaxin-1 binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(21)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	42		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.77e-09)|GBM - Glioblastoma multiforme(68;0.0694)		TTTATAGATTCAGCAAGCAGG	0.368000													47	76					0	0	1	0	0
TRIM27	5987	broad.mit.edu	37	6	28879489	28879489	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr6:28879489C>T	ENST00000377199.3	-	4	1110	c.754G>A	c.(754-756)Ggg>Agg	p.G252R	TRIM27_ENST00000498117.1_5'UTR|TRIM27_ENST00000377194.3_Missense_Mutation_p.G252R	NM_006510.4	NP_006501.1	P14373	TRI27_HUMAN	tripartite motif containing 27	252					cell proliferation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|protein trimerization|spermatogenesis|transcription, DNA-dependent	cytoplasm|integral to plasma membrane|membrane fraction|nuclear membrane|PML body	DNA binding|protein binding|transmembrane receptor protein tyrosine kinase activity|zinc ion binding	p.G252L(1)		endometrium(1)|large_intestine(2)|lung(6)|ovary(1)	10						AATGTGTCCCCAATGTCCTGC	0.373000			T	RET	papillary thyroid								33	71					0	0	1	0	0
CYP4F8	11283	broad.mit.edu	37	19	15740229	15740229	+	RNA	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:15740229C>T	ENST00000441682.2	+	0	1685							P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 8						prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(1)	26						ACTACCTTTTCAGATTTCCGG	0.602000													3	9					0	0	1	0	0
EEF1B2	1933	broad.mit.edu	37	2	207025366	207025366	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:207025366G>A	ENST00000392222.2	+	2	510	c.135G>A	c.(133-135)ccG>ccA	p.P45P	EEF1B2_ENST00000236957.5_Silent_p.P45P|EEF1B2_ENST00000392221.1_Silent_p.P45P	NM_001959.3	NP_001950.1	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta 2	45	GST C-terminal.					cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity	p.P45P(5)		breast(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(6)	16						CCAGCCCACCGCCTGCCGACT	0.448000													4	106					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149508800	149508800	+	RNA	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr7:149508800C>T	ENST00000378016.2	+	0	9539							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TGGCCTTGTGCGGAGGGTAAG	0.642000													43	81					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233344291	233344291	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:233344291G>C	ENST00000258229.9	-	13	3070	c.2836C>G	c.(2836-2838)Cta>Gta	p.L946V	PCNXL2_ENST00000430153.1_Missense_Mutation_p.L245V|PCNXL2_ENST00000488780.2_Missense_Mutation_p.L79V	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)							integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				GCTGATTGTAGAAACACTGGA	0.478000													13	49					0	0	1	0	0
DSC2	1824	broad.mit.edu	37	18	28654728	28654728	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr18:28654728G>A	ENST00000280904.6	-	12	2252	c.1809C>T	c.(1807-1809)atC>atT	p.I603I	DSC2_ENST00000251081.6_Silent_p.I603I	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	603	Cadherin 5.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			GTGGGCCATGGATAGGCTCAT	0.413000													36	58					0	0	1	0	0
KCND3	3752	broad.mit.edu	37	1	112524315	112524315	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:112524315C>T	ENST00000369697.1	-	1	1103	c.1034G>A	c.(1033-1035)gGc>gAc	p.G345D	KCND3_ENST00000302127.4_Missense_Mutation_p.G345D|KCND3_ENST00000315987.2_Missense_Mutation_p.G345D			Q9UK17	KCND3_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 3	345						sarcolemma|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|metal ion binding			NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(16)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	49		all_cancers(81;8.52e-06)|all_epithelial(167;5.65e-06)|all_lung(203;2.72e-05)|Lung NSC(69;4.56e-05)		all cancers(265;0.056)|Lung(183;0.0576)|Colorectal(144;0.1)|Epithelial(280;0.104)|COAD - Colon adenocarcinoma(174;0.222)|LUSC - Lung squamous cell carcinoma(189;0.231)		GGCCGAGGAGCCCTTCTCGGC	0.527000													46	33					0	0	1	0	0
TPSAB1	7177	broad.mit.edu	37	16	1291638	1291638	+	Nonsense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr16:1291638C>G	ENST00000461509.2	+	3	652	c.458C>G	c.(457-459)tCa>tGa	p.S153*	TPSAB1_ENST00000338844.3_Nonsense_Mutation_p.S146*			P20231	TRYB2_HUMAN	tryptase alpha/beta 1	146	Peptidase S1.				proteolysis	extracellular region	protein binding|serine-type endopeptidase activity			NS(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(4)|skin(1)	10		Hepatocellular(780;0.00369)				CCCCCTGCCTCAGAGACCTTC	0.662000													12	17					0	0	1	0	0
C10orf118	55088	broad.mit.edu	37	10	115922804	115922804	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr10:115922804C>G	ENST00000369287.3	-	2	490	c.224G>C	c.(223-225)gGa>gCa	p.G75A	C10orf118_ENST00000369285.3_Missense_Mutation_p.G75A|C10orf118_ENST00000369286.1_Missense_Mutation_p.G75A	NM_018017.2	NP_060487.2	Q7Z3E2	CJ118_HUMAN	chromosome 10 open reading frame 118	75				GGG -> IRH (in Ref. 3; AAM44457).						NS(1)|autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(9)|ovary(2)	24		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0161)|all cancers(201;0.0397)		ATCCTCACCTCCACCATGATC	0.333000													57	38					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176675521	176675521	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:176675521G>C	ENST00000367662.3	+	10	4556	c.3392G>C	c.(3391-3393)gGa>gCa	p.G1131A		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1131					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						TGTGATGATGGAGACCTTGTG	0.403000													7	41					0	0	1	0	0
PLTP	5360	broad.mit.edu	37	20	44540126	44540126	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr20:44540126G>A	ENST00000542937.1	-	1	560	c.26C>T	c.(25-27)tCc>tTc	p.S9F	PLTP_ENST00000477313.1_5'UTR|PLTP_ENST00000354050.4_Intron|PLTP_ENST00000420868.2_Intron|PLTP_ENST00000372431.3_Intron			P55058	PLTP_HUMAN	phospholipid transfer protein	0					cellular lipid metabolic process|lipid transport	extracellular region	lipid binding			endometrium(2)|kidney(2)|large_intestine(8)|lung(8)|ovary(1)	21		Myeloproliferative disorder(115;0.0122)				GGGGTCGCAGGAGTTATCTGA	0.607000													20	27					0	0	1	0	0
AKAP9	10142	broad.mit.edu	37	7	91667747	91667747	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr7:91667747G>C	ENST00000359028.2	+	18	4614	c.4389G>C	c.(4387-4389)atG>atC	p.M1463I	AKAP9_ENST00000356239.3_Missense_Mutation_p.M1451I|AKAP9_ENST00000358100.2_Missense_Mutation_p.M1463I			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	1463					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TTGTGTCAATGAGTATAGCAT	0.318000			T	BRAF	papillary thyroid								21	48					0	0	1	0	0
ZNF667	63934	broad.mit.edu	37	19	56953763	56953763	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:56953763C>T	ENST00000504904.3	-	7	1320	c.601G>A	c.(601-603)Gaa>Aaa	p.E201K	ZNF667_ENST00000591790.1_3'UTR|ZNF667_ENST00000292069.6_Missense_Mutation_p.E201K|ZNF667_ENST00000342634.3_Missense_Mutation_p.E329K			Q5HYK9	ZN667_HUMAN	zinc finger protein 667	201					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	38		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		TTATTGCATTCATGGCTTTTC	0.383000													69	138					0	0	1	0	0
KRTAP4-8	728224	broad.mit.edu	37	17	39254054	39254054	+	Missense_Mutation	SNP	A	A	T	rs76270529	by1000genomes	TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr17:39254054A>T	ENST00000333822.4	-	1	339	c.283T>A	c.(283-285)Tgc>Agc	p.C95S		NM_031960.2	NP_114166.1	Q9BYQ9	KRA48_HUMAN	keratin associated protein 4-8	95	25 X 5 AA repeats of C-C-[IKRQVHEC]- [SPRT]-[STCVQPR].					keratin filament		p.C95S(4)		endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|prostate(1)	11						ctggagatgcagcagcTAGGG	0.677000													6	77					0	0	1	0	0
WTAP	9589	broad.mit.edu	37	6	160163119	160163119	+	Splice_Site	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr6:160163119G>C	ENST00000358372.4	+	4	1843		c.e4-1		WTAP_ENST00000337387.4_Splice_Site|SOD2_ENST00000546087.1_Intron	NM_001270531.1|NM_004906.4	NP_001257460.1|NP_004897.2	Q15007	FL2D_HUMAN	Wilms tumor 1 associated protein						cell cycle|mRNA processing|RNA splicing	nuclear membrane|nucleolus				central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(6)|prostate(2)|skin(1)|urinary_tract(1)	18		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.75e-18)|BRCA - Breast invasive adenocarcinoma(81;5.93e-06)		TTTTTTATTAGATGGAAACAA	0.289000													31	65					0	0	1	0	0
SETD1A	9739	broad.mit.edu	37	16	30977380	30977380	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr16:30977380C>T	ENST00000262519.8	+	8	2864	c.2178C>T	c.(2176-2178)taC>taT	p.Y726Y		NM_014712.1	NP_055527.1	O15047	SET1A_HUMAN	SET domain containing 1A	726					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(21)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	59						AGGCAGCCTACGGCTTGCCGT	0.677000													43	37					0	0	1	0	0
SFTPA2	729238	broad.mit.edu	37	10	81319100	81319100	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr10:81319100C>G	ENST00000372325.2	-	3	224	c.140G>C	c.(139-141)aGa>aCa	p.R47T	SFTPA2_ENST00000372327.5_Missense_Mutation_p.R47T	NM_001098668.2	NP_001092138.1	Q8IWL1	SFPA2_HUMAN	surfactant protein A2	47	Collagen-like.				cell junction assembly|respiratory gaseous exchange	collagen|extracellular space	sugar binding			endometrium(1)|kidney(1)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	9	all_cancers(46;0.197)|Breast(12;0.000326)|Prostate(51;0.00985)|all_epithelial(25;0.0149)		Epithelial(14;0.00957)|all cancers(16;0.0179)|Colorectal(32;0.229)			GACACCATCTCTCCCGTCCCT	0.627000									Pulmonary Fibrosis, Idiopathic				34	112					0	0	1	0	0
PLA2G2F	64600	broad.mit.edu	37	1	20474750	20474750	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:20474750C>T	ENST00000375102.3	+	5	594	c.492C>T	c.(490-492)ctC>ctT	p.L164L		NM_022819.3	NP_073730.3	Q9BZM2	PA2GF_HUMAN	phospholipase A2, group IIF	121					lipid catabolic process|phospholipid metabolic process	extracellular region	calcium ion binding|phospholipase A2 activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	15		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000247)|Lung NSC(340;0.000285)|Breast(348;0.000812)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;8.01e-05)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.000524)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)		TTCTGTGCCTCATGAACCAGA	0.562000													59	67					0	0	1	0	0
GMEB1	10691	broad.mit.edu	37	1	29037087	29037087	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:29037087G>A	ENST00000373816.1	+	9	1062	c.924G>A	c.(922-924)aaG>aaA	p.K308K	GMEB1_ENST00000361872.4_Silent_p.K308K|GMEB1_ENST00000480454.1_3'UTR|GMEB1_ENST00000294409.2_Silent_p.K318K	NM_024482.2	NP_077808.1	Q9Y692	GMEB1_HUMAN	glucocorticoid modulatory element binding protein 1	318					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|metal ion binding|transcription coactivator activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(4)	11		Colorectal(325;3.46e-05)|Lung NSC(340;0.000451)|all_lung(284;0.00063)|Breast(348;0.00502)|Renal(390;0.00555)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)		ACACAGTCAAGAAGGTTTTAG	0.393000													70	72					0	0	1	0	0
FAM188A	80013	broad.mit.edu	37	10	15821080	15821080	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr10:15821080C>T	ENST00000378036.1	-	6	1540	c.364G>A	c.(364-366)Gat>Aat	p.D122N	FAM188A_ENST00000477891.1_5'UTR|FAM188A_ENST00000277632.3_Missense_Mutation_p.D417N			Q9H8M7	F188A_HUMAN	family with sequence similarity 188, member A	417					apoptosis	nucleus	calcium ion binding			breast(2)|endometrium(5)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|skin(2)	22						GGAGTGTCATCTGTCTGTAGC	0.428000													22	52					0	0	1	0	0
LRRC55	219527	broad.mit.edu	37	11	56954784	56954784	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr11:56954784G>A	ENST00000497933.1	+	2	1003	c.856G>A	c.(856-858)Gag>Aag	p.E286K		NM_001005210.2	NP_001005210.1	Q6ZSA7	LRC55_HUMAN	leucine rich repeat containing 55	256						integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(13)|ovary(2)|skin(2)	25						CTCACTCACTGAGGAGAGCTT	0.587000													55	99					0	0	1	0	0
SENP6	26054	broad.mit.edu	37	6	76412774	76412774	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr6:76412774C>G	ENST00000370014.3	+	19	3321	c.2702C>G	c.(2701-2703)tCc>tGc	p.S901C	SENP6_ENST00000447266.2_Missense_Mutation_p.S901C|SENP6_ENST00000370010.2_Missense_Mutation_p.S894C|SENP6_ENST00000541192.1_Intron	NM_001100409.1	NP_001093879.1	Q9GZR1	SENP6_HUMAN	SUMO1/sentrin specific peptidase 6	901	Protease.				proteolysis	cytoplasm|nucleus	cysteine-type peptidase activity			breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(12)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_hematologic(105;0.189)				AGTTTAAGTTCCACACATCAT	0.308000													73	125					0	0	1	0	0
TMC6	11322	broad.mit.edu	37	17	76120740	76120740	+	Silent	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr17:76120740G>C	ENST00000590602.1	-	8	915	c.756C>G	c.(754-756)ctC>ctG	p.L252L	TMC6_ENST00000306591.7_Silent_p.L252L|TMC6_ENST00000392467.3_Silent_p.L252L|TMC6_ENST00000322933.4_5'UTR|TMC6_ENST00000322914.3_Silent_p.L252L|TMC6_ENST00000589553.1_Silent_p.L25L			Q7Z403	TMC6_HUMAN	transmembrane channel-like 6	252						endoplasmic reticulum membrane|integral to membrane				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	14			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			GCAGGGTCTTGAGAAAGAGGA	0.677000													15	26					0	0	1	0	0
FAM208B	54906	broad.mit.edu	37	10	5798659	5798659	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr10:5798659C>T	ENST00000328090.5	+	16	7315	c.6690C>T	c.(6688-6690)atC>atT	p.I2230I		NM_017782.4	NP_060252	Q5VWN6	CJ018_HUMAN	family with sequence similarity 208, member B	2230																	ATACACTAATCATCATCATCA	0.373000													32	74					0	0	1	0	0
PARP1	142	broad.mit.edu	37	1	226558164	226558164	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:226558164C>T	ENST00000366794.5	-	15	2268	c.2125G>A	c.(2125-2127)Gca>Aca	p.A709T	PARP1_ENST00000490921.1_5'UTR	NM_001618.3	NP_001609.2	P09874	PARP1_HUMAN	poly (ADP-ribose) polymerase 1	709	PARP alpha-helical.				cellular response to insulin stimulus|protein ADP-ribosylation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nuclear envelope|nucleolus|transcription factor complex	DNA binding|identical protein binding|NAD+ ADP-ribosyltransferase activity|protein N-terminus binding|transcription factor binding|zinc ion binding			breast(2)|endometrium(4)|kidney(4)|large_intestine(8)|lung(15)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	44	Breast(184;0.133)			GBM - Glioblastoma multiforme(131;0.0531)		ATGGAGTATGCGGCCTGGATC	0.597000								Poly(ADP-ribose) polymerase (PARP) enzymes that bind to DNA					4	152					0	0	1	0	0
ZNF614	80110	broad.mit.edu	37	19	52519104	52519104	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:52519104G>A	ENST00000270649.6	-	5	2291	c.1747C>T	c.(1747-1749)Cct>Tct	p.P583S	ZNF614_ENST00000356322.6_Intron	NM_025040.3	NP_079316.2	Q8N883	ZN614_HUMAN	zinc finger protein 614	583					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	24		all_neural(266;0.0505)		GBM - Glioblastoma multiforme(134;0.00513)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		CACTTATAAGGAAGGAGCTGT	0.398000													65	126					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32826051	32826051	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr13:32826051C>G	ENST00000380250.3	+	50	7703	c.7207C>G	c.(7207-7209)Ctg>Gtg	p.L2403V		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	2403					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		TGTCCTTTCTCTGTGTGGCCA	0.383000													64	57					0	0	1	0	0
GFRA2	2675	broad.mit.edu	37	8	21552023	21552023	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr8:21552023C>T	ENST00000524240.1	-	8	1875	c.1225G>A	c.(1225-1227)Ggg>Agg	p.G409R	GFRA2_ENST00000400782.4_Missense_Mutation_p.G304R|GFRA2_ENST00000517328.1_Missense_Mutation_p.G409R|GFRA2_ENST00000518077.1_Missense_Mutation_p.G276R	NM_001495.4	NP_001486.4	O00451	GFRA2_HUMAN	GDNF family receptor alpha 2	409						anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|prostate(1)|skin(1)	7				Colorectal(74;0.0189)|COAD - Colon adenocarcinoma(73;0.0727)		GCCTTCAGCCCCTGCTCCTGC	0.607000													3	10					0	0	1	0	0
NSD1	64324	broad.mit.edu	37	5	176562542	176562542	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr5:176562542C>T	ENST00000439151.2	+	2	483	c.438C>T	c.(436-438)atC>atT	p.I146I	NSD1_ENST00000354179.4_Intron|NSD1_ENST00000347982.4_Intron|NSD1_ENST00000361032.4_Silent_p.I146I|NSD1_ENST00000511258.1_Intron	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	146					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		CAAAGACTATCAAGAATGGCT	0.443000			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			60	91					0	0	1	0	0
RNF5	6048	broad.mit.edu	37	6	32151075	32151075	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr6:32151075C>T	ENST00000427134.2	+	6	470	c.455C>T	c.(454-456)tCt>tTt	p.S152F	AGER_ENST00000438221.2_Missense_Mutation_p.R149K|AGER_ENST00000375076.4_Intron|AGER_ENST00000375055.2_Intron|AGER_ENST00000375065.5_Intron|AGER_ENST00000375069.3_Intron|AGER_ENST00000375067.3_Intron|AGER_ENST00000375070.3_Intron			Q99942	RNF5_HUMAN	ring finger protein 5, E3 ubiquitin protein ligase	0					ER-associated misfolded protein catabolic process|protein K48-linked ubiquitination|protein K63-linked ubiquitination	endoplasmic reticulum membrane|integral to membrane|mitochondrial membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|lung(7)|urinary_tract(2)	10						GGGCCGTTTTCTACTTCTCCT	0.512000													25	44					0	0	1	0	0
BMP6	654	broad.mit.edu	37	6	7727541	7727541	+	Missense_Mutation	SNP	A	A	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr6:7727541A>T	ENST00000283147.6	+	1	512	c.353A>T	c.(352-354)cAg>cTg	p.Q118L		NM_001718.4	NP_001709.1	P22004	BMP6_HUMAN	bone morphogenetic protein 6	118					BMP signaling pathway|cartilage development|growth|immune response|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	BMP receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity	p.Q118L(1)		breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(6)|ovary(1)|prostate(1)	23	Ovarian(93;0.0721)					cagcagcagcagcTGCCTCGC	0.731000													3	26					0	0	1	0	0
OR1M1	125963	broad.mit.edu	37	19	9204840	9204840	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:9204840G>T	ENST00000429566.3	+	1	986	c.920G>T	c.(919-921)aGa>aTa	p.R307I		NM_001004456.1	NP_001004456.1	Q8NGA1	OR1M1_HUMAN	olfactory receptor, family 1, subfamily M, member 1	307					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|large_intestine(3)|lung(17)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32						CTGGTCAACAGAAAGATCACC	0.502000													23	49					7.41877e-09	7.54131e-09	1	1	0
REV3L	5980	broad.mit.edu	37	6	111694547	111694547	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr6:111694547G>A	ENST00000435970.1	-	15	5593	c.4777C>T	c.(4777-4779)Cag>Tag	p.Q1593*	REV3L_ENST00000368805.1_Nonsense_Mutation_p.Q1671*|REV3L_ENST00000368802.3_Nonsense_Mutation_p.Q1671*|REV3L_ENST00000358835.3_Nonsense_Mutation_p.Q1671*			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	1671					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		ggcaaattctGATCAGCTGGG	0.343000								DNA polymerases (catalytic subunits)					42	80					0	0	1	0	0
FLNA	2316	broad.mit.edu	37	X	153580035	153580035	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chrX:153580035C>A	ENST00000422373.1	-	42	7161	c.6913G>T	c.(6913-6915)Gag>Tag	p.E2305*	FLNA_ENST00000369856.3_Nonsense_Mutation_p.E446*|FLNA_ENST00000360319.4_Nonsense_Mutation_p.E2305*|FLNA_ENST00000344736.4_Nonsense_Mutation_p.E2273*|FLNA_ENST00000369850.3_Nonsense_Mutation_p.E2313*	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	2313					actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding	p.E2313*(1)		breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ATGTGTTCCTCGTTGAACTTG	0.602000													23	11					2.48779e-11	2.54416e-11	1	1	0
DOCK2	1794	broad.mit.edu	37	5	169143252	169143252	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr5:169143252C>T	ENST00000256935.8	+	20	2057	c.1977C>T	c.(1975-1977)atC>atT	p.I659I	DOCK2_ENST00000520908.1_Silent_p.I151I|DOCK2_ENST00000540750.1_5'UTR	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	659	DHR-1.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCTTCAACATCATGATGGAGC	0.418000													33	85					0	0	1	0	0
BORA	79866	broad.mit.edu	37	13	73329354	73329354	+	Nonstop_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr13:73329354G>C	ENST00000390667.5	+	12	1777	c.1680G>C	c.(1678-1680)taG>taC	p.*560Y	BORA_ENST00000377815.3_Nonstop_Mutation_p.*490Y	NM_024808.2	NP_079084.2	Q6PGQ7	BORA_HUMAN	bora, aurora kinase A activator	0					cell division|mitosis|regulation of mitosis|regulation of mitotic spindle organization|regulation of protein localization		protein kinase binding										GCAGTCCATAGAATGCCTCTG	0.408000													37	90					0	0	1	0	0
SNORD3A	780851	broad.mit.edu	37	17	19091383	19091383	+	RNA	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr17:19091383G>A	ENST00000365494.1	+	0	55																											aagtttctctgaacgtgtaga	0.507000													46	352					0	0	1	0	0
SLC16A7	9194	broad.mit.edu	37	12	60165093	60165093	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr12:60165093C>A	ENST00000261187.4	+	3	475	c.311C>A	c.(310-312)tCc>tAc	p.S104Y	SLC16A7_ENST00000552432.1_Missense_Mutation_p.S104Y|SLC16A7_ENST00000547379.1_Missense_Mutation_p.S104Y|SLC16A7_ENST00000543448.1_Missense_Mutation_p.S5Y|SLC16A7_ENST00000552024.1_Missense_Mutation_p.S104Y	NM_004731.4	NP_004722.2	O60669	MOT2_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 7	104						integral to plasma membrane|membrane fraction	pyruvate secondary active transmembrane transporter activity|secondary active monocarboxylate transmembrane transporter activity|symporter activity			endometrium(1)|large_intestine(14)|liver(2)|lung(11)|ovary(1)|skin(1)	30				GBM - Glioblastoma multiforme(3;0.0303)	Pyruvic acid(DB00119)	GTGTTGGCCTCCTTTAGTAGC	0.443000													105	185					1.12856e-70	1.22051e-70	1	1	0
F11R	50848	broad.mit.edu	37	1	160970508	160970508	+	Missense_Mutation	SNP	G	G	A	rs116727809	byFrequency	TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:160970508G>A	ENST00000368026.6	-	4	575	c.301C>T	c.(301-303)Cgg>Tgg	p.R101W	F11R_ENST00000289779.3_3'UTR|F11R_ENST00000472573.1_5'UTR|F11R_ENST00000537746.1_Intron	NM_016946.4	NP_058642.1	Q9Y624	JAM1_HUMAN	F11 receptor	101	Ig-like V-type 1.				blood coagulation|inflammatory response|interspecies interaction between organisms|leukocyte migration|tight junction assembly	integral to membrane|tight junction				breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)	12	all_cancers(52;6.73e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00207)			GTGTCTTCCCGTGTCACGGAC	0.542000													31	46					0	0	1	0	0
TRIB2	28951	broad.mit.edu	37	2	12858571	12858571	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:12858571G>A	ENST00000155926.4	+	1	1557	c.138G>A	c.(136-138)ccG>ccA	p.P46P	TRIB2_ENST00000381465.2_Intron|TRIB2_ENST00000405331.3_Silent_p.P46P	NM_021643.3	NP_067675.1	Q92519	TRIB2_HUMAN	tribbles pseudokinase 2	46					negative regulation of fat cell differentiation|negative regulation of interleukin-10 biosynthetic process|negative regulation of protein kinase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of MAP kinase activity	cytoplasm|cytoskeleton|nucleus	ATP binding|protein kinase activity|protein kinase inhibitor activity|transcription factor binding|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(8)|lung(5)|prostate(1)|skin(1)|stomach(1)	19	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					TCGGCTCCCCGAGCCCGCCCG	0.552000											OREG0014450	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	112	111					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179641878	179641878	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:179641878G>A	ENST00000589042.1	-	27	5036	c.4812C>T	c.(4810-4812)atC>atT	p.I1604I	TTN_ENST00000342175.6_Silent_p.I1558I|TTN_ENST00000342992.6_Silent_p.I1604I|TTN_ENST00000460472.2_Silent_p.I1558I|RP11-88L24.4_ENST00000582038.2_RNA|TTN_ENST00000360870.5_Silent_p.I1604I|TTN_ENST00000591111.1_Silent_p.I1604I|TTN_ENST00000359218.5_Silent_p.I1558I	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1340	Ig-like 7.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATACTTACCTGATTTTGGGAT	0.378000													64	133					0	0	1	0	0
ZNF484	83744	broad.mit.edu	37	9	95618147	95618147	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr9:95618147C>A	ENST00000395505.2	-	2	165	c.73G>T	c.(73-75)Gaa>Taa	p.E25*	ZNF484_ENST00000395506.3_Nonsense_Mutation_p.E63*|ZNF484_ENST00000375495.3_Nonsense_Mutation_p.E61*|ANKRD19P_ENST00000473204.1_RNA|ZNF484_ENST00000332591.6_Nonsense_Mutation_p.E25*	NM_001261459.1|NM_001261460.1	NP_001248388.1|NP_001248389.1	Q5JVG2	ZN484_HUMAN	zinc finger protein 484	61	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|kidney(8)|large_intestine(10)|lung(10)|prostate(2)	33						TCTTCTTGTTCCAAGCTGAAG	0.468000													82	108					4.64247e-43	4.98091e-43	1	1	0
ITGB3BP	23421	broad.mit.edu	37	1	63920103	63920103	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:63920103G>C	ENST00000371092.3	-	7	552	c.492C>G	c.(490-492)atC>atG	p.I164M	ITGB3BP_ENST00000271002.10_Missense_Mutation_p.I125M|ITGB3BP_ENST00000283568.8_Missense_Mutation_p.I125M|ITGB3BP_ENST00000461681.1_5'UTR	NM_001206739.1	NP_001193668.1	Q13352	CENPR_HUMAN	integrin beta 3 binding protein (beta3-endonexin)	125					apoptosis|cell adhesion|CenH3-containing nucleosome assembly at centromere|induction of apoptosis by extracellular signals|mitotic prometaphase|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome, centromeric region|cytosol|membrane fraction|nucleoplasm	protein C-terminus binding|signal transducer activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|upper_aerodigestive_tract(1)	9						ATGCACAGGAGATTCCAATGA	0.338000													13	60					0	0	1	0	0
SLC8A3	6547	broad.mit.edu	37	14	70633746	70633746	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr14:70633746G>C	ENST00000381269.2	-	2	2147	c.1394C>G	c.(1393-1395)tCc>tGc	p.S465C	SLC8A3_ENST00000357887.3_Missense_Mutation_p.S465C|SLC8A3_ENST00000534137.1_Missense_Mutation_p.S465C|SLC8A3_ENST00000356921.2_Missense_Mutation_p.S465C|SLC8A3_ENST00000528359.1_Missense_Mutation_p.S465C	NM_058240.2|NM_183002.1	NP_489479.1|NP_892114.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	465	Calx-beta 1.				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		TATGCCCACGGAGAACTCCTT	0.512000													94	154					0	0	1	0	0
LRCH3	84859	broad.mit.edu	37	3	197562663	197562663	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:197562663G>A	ENST00000438796.2	+	9	1265	c.1221G>A	c.(1219-1221)gcG>gcA	p.A407A	LRCH3_ENST00000414675.2_Intron|LRCH3_ENST00000441090.2_Intron|LRCH3_ENST00000536618.1_Silent_p.A2A|LRCH3_ENST00000334859.4_Silent_p.A407A|LRCH3_ENST00000425562.2_Silent_p.A407A			Q96II8	LRCH3_HUMAN	leucine-rich repeats and calponin homology (CH) domain containing 3	407						extracellular region				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;4.82e-24)|all cancers(36;3.61e-22)|OV - Ovarian serous cystadenocarcinoma(49;7.08e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.119)		AGTTTATGGCGTATATTGAAC	0.438000													4	232					0	0	1	0	0
JMJD1C	221037	broad.mit.edu	37	10	64974483	64974483	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr10:64974483C>A	ENST00000399262.2	-	8	1662	c.1444G>T	c.(1444-1446)Gaa>Taa	p.E482*	JMJD1C_ENST00000399251.1_Nonsense_Mutation_p.E263*|JMJD1C_ENST00000542921.1_Nonsense_Mutation_p.E300*|JMJD1C_ENST00000402544.1_Nonsense_Mutation_p.E263*	NM_032776.1	NP_116165.1	Q15652	JHD2C_HUMAN	jumonji domain containing 1C	482					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(9)|lung(27)|ovary(6)|prostate(4)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	77	Prostate(12;0.0119)|all_hematologic(501;0.191)					ATATTGCATTCCTGAGGAAGT	0.368000													82	136					3.76054e-38	4.01559e-38	1	1	0
ARHGEF18	23370	broad.mit.edu	37	19	7518556	7518556	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:7518556C>A	ENST00000359920.6	+	7	1748	c.1495C>A	c.(1495-1497)Ctg>Atg	p.L499M	CTD-2207O23.3_ENST00000593531.1_Silent_p.T456T|ARHGEF18_ENST00000319670.9_Missense_Mutation_p.L341M	NM_001130955.1	NP_001124427.1	Q6ZSZ5	ARHGI_HUMAN	Rho/Rac guanine nucleotide exchange factor (GEF) 18	499	PH.				actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell shape|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(4)|ovary(2)|prostate(2)|stomach(1)|urinary_tract(1)	23		Renal(5;0.0902)				GCAGCTCCACCTGGAGGGCAT	0.582000													31	71					6.00712e-18	6.26629e-18	1	1	0
FGA	2243	broad.mit.edu	37	4	155505852	155505852	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr4:155505852G>C	ENST00000302053.3	-	6	2103	c.2025C>G	c.(2023-2025)atC>atG	p.I675M		NM_000508.3	NP_000499.1	P02671	FIBA_HUMAN	fibrinogen alpha chain	675	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	73	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	TTCTTTGCTGGATCAAAAGCC	0.458000													31	64					0	0	1	0	0
SUPT6H	6830	broad.mit.edu	37	17	27014225	27014225	+	Silent	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr17:27014225C>G	ENST00000314616.6	+	22	3103	c.2820C>G	c.(2818-2820)ctC>ctG	p.L940L	SUPT6H_ENST00000347486.4_Silent_p.L940L	NM_003170.3	NP_003161.2	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog (S. cerevisiae)	940					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	Lung NSC(42;0.00431)					TCCTGTGTCTCAAGTTTCACC	0.567000													67	106					0	0	1	0	0
CTAGE9	643854	broad.mit.edu	37	6	132031178	132031178	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr6:132031178G>C	ENST00000314099.8	-	1	1028	c.980C>G	c.(979-981)tCt>tGt	p.S327C	ENPP3_ENST00000414305.1_Intron|ENPP3_ENST00000358229.5_Intron|ENPP3_ENST00000357639.3_Intron	NM_001145659.1|NM_001278507.1	NP_001139131.1|NP_001265436.1	A4FU28	CTGE9_HUMAN	CTAGE family, member 9	327						integral to membrane				endometrium(1)|lung(1)	2						GCTTTTTAAAGAAACATTTAA	0.338000													14	47					0	0	1	0	0
UQCRC1	7384	broad.mit.edu	37	3	48642088	48642088	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:48642088C>T	ENST00000203407.5	-	4	839	c.423G>A	c.(421-423)ccG>ccA	p.P141P		NM_003365.2	NP_003356.2	P31930	QCR1_HUMAN	ubiquinol-cytochrome c reductase core protein I	141					aerobic respiration|proteolysis		metalloendopeptidase activity|ubiquinol-cytochrome-c reductase activity|zinc ion binding			breast(1)|endometrium(2)|large_intestine(2)|lung(2)|ovary(2)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(1)	16				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)	Atovaquone(DB01117)	TGTTACCTTTCGGCAGATCCT	0.577000													23	32					0	0	1	0	0
CACNA2D4	93589	broad.mit.edu	37	12	1993960	1993960	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr12:1993960C>G	ENST00000382722.5	-	11	1608	c.1246G>C	c.(1246-1248)Gag>Cag	p.E416Q	CACNA2D4_ENST00000588077.1_Missense_Mutation_p.E352Q|CACNA2D4_ENST00000585732.1_Missense_Mutation_p.E332Q|CACNA2D4_ENST00000587995.1_Missense_Mutation_p.E416Q|CACNA2D4_ENST00000585708.1_Missense_Mutation_p.E352Q|CACNA2D4_ENST00000586184.1_Missense_Mutation_p.E416Q	NM_172364.4	NP_758952.4	Q7Z3S7	CA2D4_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 4	416	VWFA.					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			endometrium(3)|kidney(2)|large_intestine(1)|liver(1)|lung(27)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	39	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		TTATACTTCTCAAACACCGGC	0.577000													9	33					0	0	1	0	0
PCDHA12	56137	broad.mit.edu	37	5	140256594	140256594	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr5:140256594G>A	ENST00000398631.2	+	1	1537	c.1537G>A	c.(1537-1539)Gag>Aag	p.E513K	PCDHA6_ENST00000529310.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018903.2|NM_031864.2	NP_061726.1|NP_114070.1														NS(4)|breast(2)|cervix(1)|endometrium(19)|kidney(8)|large_intestine(8)|liver(2)|lung(25)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGCACGCGGAGAGCGGCAA	0.701000													70	124					0	0	1	0	0
HNF1A	6927	broad.mit.edu	37	12	121431453	121431453	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr12:121431453G>C	ENST00000257555.6	+	3	883	c.657G>C	c.(655-657)gaG>gaC	p.E219D	HNF1A_ENST00000402929.1_Missense_Mutation_p.E219D|HNF1A_ENST00000543427.1_Missense_Mutation_p.E102D|HNF1A_ENST00000538626.1_Intron|HNF1A_ENST00000400024.2_Missense_Mutation_p.E219D|HNF1A_ENST00000541395.1_Missense_Mutation_p.E219D|HNF1A_ENST00000544413.1_Missense_Mutation_p.E219D			P20823	HNF1A_HUMAN	HNF1 homeobox A	219					glucose homeostasis|glucose import|insulin secretion|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|renal glucose absorption	cytoplasm|nucleus|protein complex	DNA binding|protein dimerization activity|protein heterodimerization activity|protein homodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(8)|large_intestine(19)|liver(175)|lung(9)|ovary(2)|prostate(1)|urinary_tract(1)	221	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					AGGCCTATGAGAGGCAGAAGA	0.582000									Hepatic Adenoma, Familial Clustering of				11	38					0	0	1	0	0
TRIM32	22954	broad.mit.edu	37	9	119460715	119460715	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr9:119460715G>A	ENST00000450136.1	+	2	855	c.694G>A	c.(694-696)Gag>Aag	p.E232K	ASTN2_ENST00000313400.4_Intron|ASTN2_ENST00000361209.2_Intron|ASTN2_ENST00000361477.3_Intron|TRIM32_ENST00000373983.2_Missense_Mutation_p.E232K|ASTN2_ENST00000373996.3_Intron	NM_001099679.1|NM_012210.3	NP_001093149.1|NP_036342.2	Q13049	TRI32_HUMAN	tripartite motif containing 32	232					fat cell differentiation|innate immune response|negative regulation of apoptosis|negative regulation of fibroblast proliferation|positive regulation of cell cycle|positive regulation of cell growth|positive regulation of cell migration|positive regulation of neurogenesis|positive regulation of neuron differentiation|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein catabolic process|positive regulation of proteolysis|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to tumor necrosis factor|response to UV	nucleus	myosin binding|protein self-association|RNA binding|Tat protein binding|transcription coactivator activity|translation initiation factor binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(5)|liver(1)|lung(6)|prostate(1)|skin(2)|urinary_tract(1)	26						TAACATTGCAGAGGTGCAGGC	0.527000													25	38					0	0	1	0	0
GALNT15	117248	broad.mit.edu	37	3	16254234	16254234	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:16254234C>T	ENST00000339732.5	+	6	1859	c.1356C>T	c.(1354-1356)ttC>ttT	p.F452F	GALNT15_ENST00000437509.1_Silent_p.F452F	NM_054110.4	NP_473451.3			UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15																		AAGAAACCTTCTACAAGCATA	0.572000													40	66					0	0	1	0	0
ACOXL	55289	broad.mit.edu	37	2	111556604	111556604	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:111556604C>T	ENST00000389811.4	+	7	698	c.474C>T	c.(472-474)ttC>ttT	p.F158F	ACOXL_ENST00000439055.1_Silent_p.F158F|ACOXL_ENST00000340561.4_Silent_p.F158F			Q9NUZ1	ACOXL_HUMAN	acyl-CoA oxidase-like	158					fatty acid beta-oxidation	peroxisome	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity			kidney(1)|large_intestine(4)|lung(10)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(1)	21						CCCACTGTTTCATCGTTCCTG	0.468000													66	111					0	0	1	0	0
EXO5	64789	broad.mit.edu	37	1	40981299	40981299	+	Silent	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:40981299C>G	ENST00000372703.1	+	2	2157	c.1083C>G	c.(1081-1083)ctC>ctG	p.L361L	EXO5_ENST00000358527.2_Silent_p.L361L|EXO5_ENST00000296380.4_Silent_p.L361L					exonuclease 5																		GTGGAGTGCTCAGCTCTACAC	0.512000													10	48					0	0	1	0	0
STAT4	6775	broad.mit.edu	37	2	191919232	191919232	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:191919232C>G	ENST00000392320.2	-	14	1549	c.1235G>C	c.(1234-1236)gGa>gCa	p.G412A	STAT4_ENST00000358470.4_Missense_Mutation_p.G412A	NM_003151.3	NP_003142.1	Q14765	STAT4_HUMAN	signal transducer and activator of transcription 4	412					JAK-STAT cascade	cytoplasm|nucleus	calcium ion binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(4)|endometrium(1)|kidney(2)|large_intestine(6)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.0864)|all cancers(119;0.204)			TCCTTTACCTCCAGCACTGGA	0.323000													44	112					0	0	1	0	0
UBXN7	26043	broad.mit.edu	37	3	196089367	196089367	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:196089367C>T	ENST00000296328.4	-	9	1100	c.1026G>A	c.(1024-1026)gaG>gaA	p.E342E	UBXN7_ENST00000428095.1_Silent_p.E180E|UBXN7_ENST00000535858.1_Silent_p.E194E	NM_015562.1	NP_056377.1	O94888	UBXN7_HUMAN	UBX domain protein 7	342	Poly-Glu.						protein binding			NS(1)|endometrium(2)|large_intestine(4)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	18						TGGCAAGATTCTCTACCTCTT	0.463000													70	144					0	0	1	0	0
FBXO28	23219	broad.mit.edu	37	1	224321828	224321828	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:224321828G>T	ENST00000366862.5	+	3	473	c.430G>T	c.(430-432)Gct>Tct	p.A144S	FBXO28_ENST00000424254.2_Missense_Mutation_p.A144S	NM_015176.3	NP_055991.1	Q9NVF7	FBX28_HUMAN	F-box protein 28	144										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(3)|ovary(2)|skin(1)	10	Breast(184;0.206)			GBM - Glioblastoma multiforme(131;0.0363)		AGACATTCTTGCTGCTGTTGA	0.348000													20	17					2.94398e-08	2.98812e-08	1	1	0
SPTB	6710	broad.mit.edu	37	14	65233466	65233466	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr14:65233466G>A	ENST00000389722.3	-	31	6376	c.6323C>T	c.(6322-6324)gCg>gTg	p.A2108V	SPTB_ENST00000389721.5_Missense_Mutation_p.A2108V|SPTB_ENST00000556626.1_Missense_Mutation_p.A2108V|SPTB_ENST00000389720.3_Silent_p.C2091C|SPTB_ENST00000542895.1_Missense_Mutation_p.A2108V	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	2108					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		CTCGGTGGCCGCATGGTGGGA	0.592000													4	227					0	0	1	0	0
ANXA7	310	broad.mit.edu	37	10	75158007	75158007	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr10:75158007C>T	ENST00000372921.5	-	3	247	c.191G>A	c.(190-192)gGa>gAa	p.G64E	ANXA7_ENST00000492380.1_5'UTR|ANXA7_ENST00000535178.1_5'UTR	NM_001156.3	NP_001147.1	P20073	ANXA7_HUMAN	annexin A7		Repeat-rich region.						calcium ion binding|calcium-dependent phospholipid binding|calcium-dependent protein binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	26	Prostate(51;0.0119)					TGGATAACCTCCAGGCGCAGG	0.577000													18	23					0	0	1	0	0
NME9	347736	broad.mit.edu	37	3	138037058	138037058	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:138037058C>T	ENST00000383180.2	-	6	370	c.133G>A	c.(133-135)Gag>Aag	p.E45K	NME9_ENST00000484930.1_Intron|NME9_ENST00000536478.1_Missense_Mutation_p.E45K|NME9_ENST00000341790.5_Intron|NME9_ENST00000317876.4_Missense_Mutation_p.E45K|NME9_ENST00000333911.3_Missense_Mutation_p.E67K	NM_178130.2	NP_835231.1	Q86XW9	TXND6_HUMAN	NME/NM23 family member 9	67	Thioredoxin.				cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|UTP biosynthetic process	cytoplasm|cytoskeleton	ATP binding|nucleoside diphosphate kinase activity										CGATCTGCCTCTGCCTAAAGA	0.488000													30	44					0	0	1	0	0
TPBG	7162	broad.mit.edu	37	6	83074928	83074928	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr6:83074928G>A	ENST00000369750.3	+	2	867	c.250G>A	c.(250-252)Gag>Aag	p.E84K	TPBG_ENST00000535040.1_Missense_Mutation_p.E84K|TPBG_ENST00000543496.1_Missense_Mutation_p.E84K			Q13641	TPBG_HUMAN	trophoblast glycoprotein	84	LRRNT.				cell adhesion	integral to plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)	15		all_cancers(76;0.000805)|Acute lymphoblastic leukemia(125;3.85e-06)|all_hematologic(105;0.0017)|all_epithelial(107;0.0897)		BRCA - Breast invasive adenocarcinoma(397;0.107)		CAATCTGACCGAGGTGCCCAC	0.726000													20	25					0	0	1	0	0
TBC1D22B	55633	broad.mit.edu	37	6	37247217	37247217	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr6:37247217C>G	ENST00000373491.3	+	3	397	c.251C>G	c.(250-252)tCt>tGt	p.S84C		NM_017772.2	NP_060242.2	Q9NU19	TB22B_HUMAN	TBC1 domain family, member 22B	84						intracellular	Rab GTPase activator activity			breast(1)|endometrium(1)|large_intestine(2)|lung(10)|prostate(1)	15			OV - Ovarian serous cystadenocarcinoma(102;0.241)			TCCTCACCTTCTTTCCAAACT	0.463000													59	103					0	0	1	0	0
DOPEY1	23033	broad.mit.edu	37	6	83843985	83843985	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr6:83843985C>T	ENST00000349129.2	+	19	3109	c.2849C>T	c.(2848-2850)tCt>tTt	p.S950F	DOPEY1_ENST00000369739.3_Missense_Mutation_p.S941F|DOPEY1_ENST00000237163.5_Missense_Mutation_p.S931F	NM_015018.3	NP_055833.2	Q5JWR5	DOP1_HUMAN	dopey family member 1	950					protein transport					breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(16)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	67		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		AAATCTTCATCTTTTGTACGT	0.368000													26	48					0	0	1	0	0
ADCY2	108	broad.mit.edu	37	5	7789816	7789816	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr5:7789816A>G	ENST00000338316.4	+	20	2620	c.2531A>G	c.(2530-2532)gAg>gGg	p.E844G	ADCY2_ENST00000537121.1_Missense_Mutation_p.E664G	NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	844					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						GAGCGGGAGGAGATAGAGACC	0.483000													61	75					0	0	1	0	0
PCDH20	64881	broad.mit.edu	37	13	61987206	61987206	+	Silent	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr13:61987206G>C	ENST00000409186.1	-	5	3131	c.1026C>G	c.(1024-1026)gtC>gtG	p.V342V	PCDH20_ENST00000409204.4_Silent_p.V342V			Q8N6Y1	PCD20_HUMAN	protocadherin 20	315	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(14)|liver(1)|lung(23)|ovary(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	58		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		CCACAGCCTGGACAGCTGCAA	0.428000													77	98					0	0	1	0	0
TNKS	8658	broad.mit.edu	37	8	9413781	9413781	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr8:9413781C>T	ENST00000310430.6	+	1	358	c.332C>T	c.(331-333)tCa>tTa	p.S111L	RP11-375N15.2_ENST00000607598.1_RNA|TNKS_ENST00000520408.1_Missense_Mutation_p.S111L|TNKS_ENST00000522110.1_Missense_Mutation_p.S111L	NM_003747.2	NP_003738.2	O95271	TNKS1_HUMAN	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	111					mitotic spindle organization|mRNA transport|negative regulation of DNA binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of telomere maintenance via telomerase|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein polyubiquitination|protein transport|spindle assembly|transmembrane transport|Wnt receptor signaling pathway	chromosome, centromeric region|Golgi membrane|microsome|nuclear chromosome, telomeric region|nuclear membrane|nuclear pore|pericentriolar material	NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding			NS(1)|endometrium(10)|kidney(6)|large_intestine(4)|lung(17)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)	49				COAD - Colon adenocarcinoma(149;0.0467)		GTTTCTACTTCATCTGCCGCT	0.617000													84	71					0	0	1	0	0
FCRL6	343413	broad.mit.edu	37	1	159778937	159778937	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:159778937G>C	ENST00000321935.6	+	5	613	c.527G>C	c.(526-528)gGa>gCa	p.G176A	FCRL6_ENST00000339348.5_Missense_Mutation_p.G169A|FCRL6_ENST00000392235.3_Intron|FCRL6_ENST00000368106.3_Missense_Mutation_p.G169A	NM_001284217.1	NP_001271146.1	Q6DN72	FCRL6_HUMAN	Fc receptor-like 6	169	Ig-like C2-type 2.					integral to membrane				NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	24	all_hematologic(112;0.0597)					TGCATCCCGGGAGCCAAGGAG	0.637000													13	91					0	0	1	0	0
ABCA1	19	broad.mit.edu	37	9	107591232	107591232	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr9:107591232G>A	ENST00000374736.3	-	15	2474	c.2080C>T	c.(2080-2082)Ctt>Ttt	p.L694F	ABCA1_ENST00000494467.1_5'UTR	NM_005502.3	NP_005493.2	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 1	694					Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(31)|liver(1)|lung(40)|ovary(5)|pancreas(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	115				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GCGCTCACAAGAAGAGGAATG	0.542000													25	42					0	0	1	0	0
DPY19L4	286148	broad.mit.edu	37	8	95774052	95774052	+	Missense_Mutation	SNP	A	A	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr8:95774052A>T	ENST00000414645.2	+	8	959	c.860A>T	c.(859-861)cAa>cTa	p.Q287L		NM_181787.2	NP_861452.2	Q7Z388	D19L4_HUMAN	dpy-19-like 4 (C. elegans)	287						integral to membrane				breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(2)	21	Breast(36;3.85e-06)					TCAGTGGAGCAAAGTGACAAG	0.338000													78	82					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52555955	52555955	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:52555955C>T	ENST00000321725.6	+	58	6335	c.6259C>T	c.(6259-6261)Cgt>Tgt	p.R2087C		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	2087	EGF-like 14.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		AGGGGATGGCCGTGTGTGTAC	0.642000													14	46					0	0	1	0	0
GNA15	2769	broad.mit.edu	37	19	3155896	3155896	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:3155896C>T	ENST00000262958.3	+	5	948	c.690C>T	c.(688-690)atC>atT	p.I230I		NM_002068.2	NP_002059.2	P30679	GNA15_HUMAN	guanine nucleotide binding protein (G protein), alpha 15 (Gq class)	230					activation of phospholipase C activity by dopamine receptor signaling pathway|activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			large_intestine(5)|lung(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.04e-05)|OV - Ovarian serous cystadenocarcinoma(105;5.08e-113)|Epithelial(107;6.19e-111)|all cancers(105;6.19e-103)|BRCA - Breast invasive adenocarcinoma(158;0.00145)|STAD - Stomach adenocarcinoma(1328;0.184)		TCGCCCTCATCTACCTGGCCT	0.602000													25	33					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	39075595	39075595	+	Missense_Mutation	SNP	C	C	T	rs118192147		TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:39075595C>T	ENST00000355481.4	+	101	14775	c.14644C>T	c.(14644-14646)Cac>Tac	p.H4882Y	RYR1_ENST00000360985.3_Missense_Mutation_p.H4882Y|RYR1_ENST00000359596.3_Missense_Mutation_p.H4887Y	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	4887					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TTACCTGTTTCACATGTACGT	0.582000													21	53					0	0	1	0	0
TRIM4	89122	broad.mit.edu	37	7	99506363	99506363	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr7:99506363C>G	ENST00000355947.2	-	4	769	c.640G>C	c.(640-642)Gag>Cag	p.E214Q	TRIM4_ENST00000349062.2_Missense_Mutation_p.E188Q|TRIM4_ENST00000354241.5_Missense_Mutation_p.E188Q	NM_033017.3	NP_148977.2	Q9C037	TRIM4_HUMAN	tripartite motif containing 4	214					protein trimerization	cytoplasm|plasma membrane	zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(1)	17	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)	Ovarian(593;0.238)				AACAGGTCCTCTTCTTCAACC	0.408000													46	108					0	0	1	0	0
PPP1R14D	54866	broad.mit.edu	37	15	41107939	41107939	+	Missense_Mutation	SNP	G	G	A	rs140774733		TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr15:41107939G>A	ENST00000427255.2	-	5	576	c.509C>T	c.(508-510)tCa>tTa	p.S170L	PPP1R14D_ENST00000299174.5_Silent_p.L131L	NM_001130143.1	NP_001123615.1	Q9NXH3	PP14D_HUMAN	protein phosphatase 1, regulatory (inhibitor) subunit 14D	0					regulation of phosphorylation	cytoplasm	protein phosphatase inhibitor activity			breast(1)|large_intestine(2)|lung(2)|skin(1)	6		all_cancers(109;6.29e-14)|all_epithelial(112;1.48e-11)|Lung NSC(122;5.77e-09)|all_lung(180;1.08e-07)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;2.88e-05)|COAD - Colon adenocarcinoma(120;0.153)|BRCA - Breast invasive adenocarcinoma(123;0.166)		TGAGTTGACTGAGCAGCTCAG	0.567000													17	21					0	0	1	0	0
MC5R	4161	broad.mit.edu	37	18	13826334	13826334	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr18:13826334C>T	ENST00000324750.3	+	1	792	c.570C>T	c.(568-570)ctC>ctT	p.L190L		NM_005913.2	NP_005904.1	P33032	MC5R_HUMAN	melanocortin 5 receptor	190					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|upper_aerodigestive_tract(1)	41						TCCTGTGCCTCATCTCCATGT	0.587000													291	466					0	0	1	0	0
RBBP6	5930	broad.mit.edu	37	16	24582458	24582458	+	Silent	SNP	A	A	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr16:24582458A>C	ENST00000319715.4	+	18	4503	c.4071A>C	c.(4069-4071)tcA>tcC	p.S1357S	RBBP6_ENST00000348022.2_Silent_p.S1323S|RBBP6_ENST00000381039.3_Silent_p.S517S	NM_006910.4	NP_008841.2	Q7Z6E9	RBBP6_HUMAN	retinoblastoma binding protein 6	1357					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(1)	46				GBM - Glioblastoma multiforme(48;0.0518)		CAAAGCCATCAAATATAGTCA	0.353000													17	24					0	0	1	0	0
GFM1	85476	broad.mit.edu	37	3	158364638	158364638	+	Silent	SNP	C	C	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:158364638C>A	ENST00000486715.1	+	4	831	c.474C>A	c.(472-474)gtC>gtA	p.V158V	GFM1_ENST00000264263.5_Silent_p.V158V|GFM1_ENST00000478576.1_Silent_p.V158V	NM_024996.5	NP_079272.4	Q96RP9	EFGM_HUMAN	G elongation factor, mitochondrial 1	158					mitochondrial translational elongation	mitochondrion	GTP binding|GTPase activity|translation elongation factor activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(3)|urinary_tract(2)	22			Lung(72;0.00309)|LUSC - Lung squamous cell carcinoma(72;0.0043)			CCATGACTGTCAATCGTCAGA	0.502000													33	57					1.56442e-22	1.63949e-22	1	1	0
TM4SF18	116441	broad.mit.edu	37	3	149040056	149040056	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:149040056G>A	ENST00000296059.2	-	5	843	c.578C>T	c.(577-579)tCa>tTa	p.S193L	RP11-206M11.7_ENST00000489011.1_RNA|TM4SF18_ENST00000470080.1_Missense_Mutation_p.S193L	NM_138786.3	NP_620141.1	Q96CE8	T4S18_HUMAN	transmembrane 4 L six family member 18	193						integral to membrane				lung(1)|ovary(1)|prostate(1)	3			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			GAAGATCACTGAATAGCTTCC	0.423000													23	48					0	0	1	0	0
EEF1B2	1933	broad.mit.edu	37	2	207025358	207025358	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:207025358A>G	ENST00000392222.2	+	2	502	c.127A>G	c.(127-129)Agc>Ggc	p.S43G	EEF1B2_ENST00000236957.5_Missense_Mutation_p.S43G|EEF1B2_ENST00000392221.1_Missense_Mutation_p.S43G	NM_001959.3	NP_001950.1	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta 2	43	GST C-terminal.					cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity	p.S43G(4)		breast(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(6)	16						AGCCGTGTCCAGCCCACCGCC	0.468000													4	104					0	0	1	0	0
CLEC4D	338339	broad.mit.edu	37	12	8672821	8672821	+	Splice_Site	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr12:8672821G>C	ENST00000299665.2	+	5	577		c.e5-1			NM_080387.4	NP_525126.2	Q8WXI8	CLC4D_HUMAN	C-type lectin domain family 4, member D						innate immune response	integral to membrane	sugar binding			large_intestine(4)|lung(6)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	14	Lung SC(5;0.184)					TTTTTATGCAGAACTTTATTA	0.383000													30	39					0	0	1	0	0
PHLDB2	90102	broad.mit.edu	37	3	111604251	111604251	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:111604251G>T	ENST00000431670.2	+	2	1738	c.1327G>T	c.(1327-1329)Gag>Tag	p.E443*	PHLDB2_ENST00000477695.1_Nonsense_Mutation_p.E443*|PHLDB2_ENST00000481953.1_Nonsense_Mutation_p.E443*|PHLDB2_ENST00000478922.1_Nonsense_Mutation_p.E443*|PHLDB2_ENST00000412622.1_Nonsense_Mutation_p.E443*|PHLDB2_ENST00000393923.3_Nonsense_Mutation_p.E470*|PHLDB2_ENST00000393925.3_Nonsense_Mutation_p.E443*	NM_001134438.1	NP_001127910.1	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B, member 2	443						cytoplasm|intermediate filament cytoskeleton|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(8)|lung(23)|ovary(6)|skin(7)|stomach(1)	55						GCAGGAAATGGAGCGATTGGT	0.493000													23	47					3.08376e-08	3.12531e-08	1	1	0
SPRY2	10253	broad.mit.edu	37	13	80911179	80911179	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr13:80911179C>T	ENST00000377102.1	-	2	1639	c.662G>A	c.(661-663)tGt>tAt	p.C221Y	SPRY2_ENST00000540649.1_Missense_Mutation_p.C221Y|SPRY2_ENST00000377104.3_Missense_Mutation_p.C221Y			O43597	SPY2_HUMAN	sprouty homolog 2 (Drosophila)	221	Cys-rich.|SPR.				epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of ERK1 and ERK2 cascade|positive regulation of gene expression|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein kinase B signaling cascade	cytosol|microtubule|ruffle membrane	protein serine/threonine kinase activator activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)	12	Medulloblastoma(90;0.18)	Acute lymphoblastic leukemia(28;0.218)|Breast(118;0.244)		GBM - Glioblastoma multiforme(99;0.0318)		ACCTTTCACACAGCATACACA	0.502000													40	80					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149484617	149484617	+	RNA	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr7:149484617C>T	ENST00000378016.2	+	0	3540							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TCAGCCCCCTCTGCCCTGAGC	0.662000													9	13					0	0	1	0	0
NOP56	10528	broad.mit.edu	37	20	2638800	2638800	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr20:2638800G>A	ENST00000329276.5	+	12	2161	c.1645G>A	c.(1645-1647)Gag>Aag	p.E549K	NOP56_ENST00000492135.1_3'UTR	NM_006392.3	NP_006383.2	O00567	NOP56_HUMAN	NOP56 ribonucleoprotein	549	Lys-rich.				rRNA processing	box C/D snoRNP complex|pre-snoRNP complex	protein binding|snoRNA binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(6)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	25						TGACCCTGAGGAGGCAGGCCA	0.532000													17	23					0	0	1	0	0
OR4B1	119765	broad.mit.edu	37	11	48238598	48238598	+	Silent	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr11:48238598C>T	ENST00000309562.2	+	1	255	c.237C>T	c.(235-237)ttC>ttT	p.F79F		NM_001005470.1	NP_001005470.1	Q8NGF8	OR4B1_HUMAN	olfactory receptor, family 4, subfamily B, member 1	79					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(3)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	28						CCCCTAAATTCATCATAGACT	0.448000													90	178					0	0	1	0	0
RB1CC1	9821	broad.mit.edu	37	8	53570023	53570023	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr8:53570023C>T	ENST00000025008.5	-	15	2889	c.2366G>A	c.(2365-2367)gGa>gAa	p.G789E	RB1CC1_ENST00000435644.2_Missense_Mutation_p.G789E|RB1CC1_ENST00000521611.1_Intron|RB1CC1_ENST00000539297.1_Missense_Mutation_p.G789E	NM_014781.4	NP_055596.3	Q8TDY2	RBCC1_HUMAN	RB1-inducible coiled-coil 1	789					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			NS(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(19)|ovary(8)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	60		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				AGTATGATCTCCAAAATCCTC	0.398000													67	87					0	0	1	0	0
MAP2K5	5607	broad.mit.edu	37	15	67923241	67923241	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr15:67923241G>A	ENST00000178640.5	+	9	1188	c.561G>A	c.(559-561)ccG>ccA	p.P187P	MAP2K5_ENST00000560591.1_3'UTR|MAP2K5_ENST00000395476.2_Silent_p.P187P|MAP2K5_ENST00000354498.5_Silent_p.P151P	NM_145160.2	NP_660143.1	Q13163	MP2K5_HUMAN	mitogen-activated protein kinase kinase 5	187	Protein kinase.				nerve growth factor receptor signaling pathway		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|skin(1)	16						ATCATGTCCCGAGTGGGAAAA	0.338000													20	42					0	0	1	0	0
RXFP2	122042	broad.mit.edu	37	13	32376282	32376282	+	Splice_Site	SNP	G	G	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr13:32376282G>C	ENST00000298386.2	+	18	2076		c.e18-1		RXFP2_ENST00000380314.1_Splice_Site	NM_130806.3	NP_570718.1	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2							integral to membrane|plasma membrane				cervix(1)|endometrium(2)|large_intestine(15)|lung(13)|prostate(1)|stomach(1)	33		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		TCCTTTTCCAGACACAATGAC	0.333000													27	53					0	0	1	0	0
TBCD	6904	broad.mit.edu	37	17	80758804	80758804	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr17:80758804G>A	ENST00000355528.4	+	9	1012	c.882G>A	c.(880-882)cgG>cgA	p.R294R	TBCD_ENST00000539345.2_Silent_p.R294R|TBCD_ENST00000397466.2_5'UTR	NM_005993.4	NP_005984.3	Q9BTW9	TBCD_HUMAN	tubulin folding cofactor D	294					'de novo' posttranslational protein folding|adherens junction assembly|negative regulation of cell-substrate adhesion|negative regulation of microtubule polymerization|post-chaperonin tubulin folding pathway|tight junction assembly	adherens junction|cytoplasm|lateral plasma membrane|microtubule|tight junction	beta-tubulin binding|chaperone binding|GTPase activator activity					Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0266)|all_epithelial(8;0.0696)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.18)			CCCTGCTGCGGAAGCTGGGGG	0.627000													36	67					0	0	1	0	0
POTEM	641455	broad.mit.edu	37	14	20020049	20020049	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr14:20020049T>C	ENST00000551509.1	-	1	223	c.172A>G	c.(172-174)Agg>Ggg	p.R58G		NM_001145442.1	NP_001138914.1	A6NI47	POTEM_HUMAN	POTE ankyrin domain family, member M	58										endometrium(4)|kidney(1)|lung(4)	9						ATCTTGCTCCTGAGTGTCTTC	0.617000													23	258					0	0	1	0	0
KAT6A	7994	broad.mit.edu	37	8	41791399	41791399	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr8:41791399C>T	ENST00000396930.3	-	18	4882	c.4339G>A	c.(4339-4341)Gag>Aag	p.E1447K	KAT6A_ENST00000406337.1_Missense_Mutation_p.E1447K|KAT6A_ENST00000265713.2_Missense_Mutation_p.E1447K	NM_001099412.1	NP_001092882.1	Q92794	MYST3_HUMAN	K(lysine) acetyltransferase 6A	1447					histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding										AGAGTTTCCTCACAGTCCTGG	0.517000													63	46					0	0	1	0	0
PCDHGA6	56109	broad.mit.edu	37	5	140755099	140755099	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr5:140755099G>A	ENST00000517434.1	+	1	1449	c.1449G>A	c.(1447-1449)caG>caA	p.Q483Q	PCDHGA5_ENST00000518069.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB1_ENST00000523390.1_Intron	NM_018919.2|NM_032086.1	NP_061742.1|NP_114475.1														breast(1)|large_intestine(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGTGGACCAGAACGCCCAAG	0.577000													85	141					0	0	1	0	0
MFSD6	54842	broad.mit.edu	37	2	191301976	191301976	+	Silent	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:191301976G>A	ENST00000392328.1	+	3	1545	c.1221G>A	c.(1219-1221)gaG>gaA	p.E407E	MFSD6_ENST00000281416.7_Silent_p.E407E	NM_017694.3	NP_060164.3	Q6ZSS7	MFSD6_HUMAN	major facilitator superfamily domain containing 6	407					transmembrane transport	integral to membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(3)|stomach(1)	23						AAGAGGTGGAGATCCCGCAGG	0.502000													30	50					0	0	1	0	0
CNNM2	54805	broad.mit.edu	37	10	104679621	104679621	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr10:104679621G>A	ENST00000369878.4	+	1	1572	c.1384G>A	c.(1384-1386)Gaa>Aaa	p.E462K	CNNM2_ENST00000369875.3_Missense_Mutation_p.E462K|CNNM2_ENST00000433628.2_Missense_Mutation_p.E462K	NM_017649.4	NP_060119.3	Q9H8M5	CNNM2_HUMAN	cyclin M2		CBS 1.				ion transport	integral to membrane				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|urinary_tract(1)	19		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		GATCACCGGCGAAGCCATCCT	0.577000													24	15					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196699053	196699053	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr2:196699053G>T	ENST00000312428.6	-	48	9077	c.8977C>A	c.(8977-8979)Cct>Act	p.P2993T		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2993	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						TGACTTTGAGGATCTATCATC	0.393000													42	123					3.4345e-17	3.56619e-17	1	1	0
HLA-B	3106	broad.mit.edu	37	6	31324681	31324681	+	Missense_Mutation	SNP	C	C	T	rs137854653		TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr6:31324681C>T	ENST00000412585.2	-	2	155	c.127G>A	c.(127-129)Gag>Aag	p.E43K		NM_005514.6	NP_005505.2			major histocompatibility complex, class I, B											endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(4)|lung(4)|prostate(1)|upper_aerodigestive_tract(2)	27						AAGCGGGGCTCCCCGCGGCCG	0.701000									Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of				41	74					0	0	1	0	0
CTBS	1486	broad.mit.edu	37	1	85039999	85040007	+	In_Frame_Del	DEL	GCAGCGCCA	GCAGCGCCA	-	rs3217269		TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr1:85039999_85040007delGCAGCGCCA	ENST00000370630.5	-	1	140_148	c.92_100delTGGCGCTGC	c.(91-102)ctggcgctgcgg>cgg	p.LAL31del	CTBS_ENST00000477677.1_5'UTR	NM_004388.2	NP_004379.1	Q01459	DIAC_HUMAN	chitobiase, di-N-acetyl-							lysosome	cation binding			breast(1)|endometrium(1)|large_intestine(4)|lung(2)|ovary(1)	9				all cancers(265;0.00727)|Epithelial(280;0.0192)|OV - Ovarian serous cystadenocarcinoma(397;0.166)		GCCGCGAGCCgcagcgccagcagcgccag	0.718													5	9	---	---	---	---					
ARIH2	10425	broad.mit.edu	37	3	49011238	49011238	+	Frame_Shift_Del	DEL	C	C	-			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:49011238delC	ENST00000356401.4	+	9	1216	c.877delC	c.(877-879)cacfs	p.H293fs	ARIH2_ENST00000490095.1_3'UTR|ARIH2_ENST00000449376.1_Frame_Shift_Del_p.H293fs	NM_006321.2	NP_006312.1	O95376	ARI2_HUMAN	ariadne RBR E3 ubiquitin protein ligase 2	293					developmental cell growth|hemopoietic stem cell proliferation|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)	13				BRCA - Breast invasive adenocarcinoma(193;9.42e-05)|Kidney(197;0.00258)|KIRC - Kidney renal clear cell carcinoma(197;0.00269)		CATTAGTGCTCACACTAAAGA	0.502													30	107	---	---	---	---					
ALAS1	211	broad.mit.edu	37	3	52236745	52236745	+	Frame_Shift_Del	DEL	G	G	-			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:52236745delG	ENST00000394965.2	+	4	782	c.422delG	c.(421-423)aggfs	p.R141fs	ALAS1_ENST00000469224.1_Frame_Shift_Del_p.R141fs|ALAS1_ENST00000484952.1_Frame_Shift_Del_p.R141fs|ALAS1_ENST00000310271.2_Frame_Shift_Del_p.R141fs	NM_000688.5	NP_000679.1	P13196	HEM1_HUMAN	aminolevulinate, delta-, synthase 1	141					heme biosynthetic process	mitochondrial matrix	5-aminolevulinate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			endometrium(3)|kidney(3)|large_intestine(7)|liver(2)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	23				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.000583)|KIRC - Kidney renal clear cell carcinoma(197;0.000751)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	AATGCCGTGAGGAAAGGTAAG	0.473													12	28	---	---	---	---					
LOC101243545	101243545	broad.mit.edu	37	3	161146872	161146873	+	RNA	DEL	AT	AT	-			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr3:161146872_161146873delAT	ENST00000473595.1	+	0	1231					NR_102265.1																						TGGTGAAAAGATATATATATAT	0.342													9	26	---	---	---	---					
IMPA1P	650747	broad.mit.edu	37	8	82539255	82539256	+	RNA	INS	-	-	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr8:82539255_82539256insT	ENST00000522318.1	-	0	127																											TTATAGAATAGTTTTTTCCACA	0.327													5	11	---	---	---	---					
TAF1L	138474	broad.mit.edu	37	9	32633584	32633584	+	Frame_Shift_Del	DEL	T	T	-			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr9:32633584delT	ENST00000242310.4	-	1	2083	c.1994delA	c.(1993-1995)aagfs	p.K665fs	RP11-555J4.4_ENST00000430787.1_RNA	NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	665					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding	p.K665fs*4(2)		breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		CATCTTGGCCTTTTTTTTGAT	0.478													7	225	---	---	---	---					
KIAA0368	23392	broad.mit.edu	37	9	114148709	114148709	+	Frame_Shift_Del	DEL	G	G	-			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr9:114148709delG	ENST00000259335.4	-	33	4008	c.4009delC	c.(4009-4011)caafs	p.Q1337fs	KIAA0368_ENST00000374378.3_5'UTR|KIAA0368_ENST00000338205.5_Frame_Shift_Del_p.Q1159fs	NM_001080398.1	NP_001073867.1			KIAA0368											NS(2)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(23)|prostate(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	65						ACCAAATCTTGAAGAATTTCT	0.289													23	49	---	---	---	---					
SLC48A1	55652	broad.mit.edu	37	12	48173996	48173997	+	Frame_Shift_Ins	INS	-	-	T			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr12:48173996_48173997insT	ENST00000442218.2	+	3	470_471	c.373_374insT	c.(373-375)ctgfs	p.L125fs	SLC48A1_ENST00000547002.1_Frame_Shift_Ins_p.L68fs|SLC48A1_ENST00000442892.2_Frame_Shift_Ins_p.L68fs	NM_017842.2	NP_060312.2	Q6P1K1	HRG1_HUMAN	solute carrier family 48 (heme transporter), member 1	125					transport	endosome membrane|integral to membrane|lysosomal membrane				large_intestine(1)|lung(3)|urinary_tract(1)	5						GTGGGCCTTCCTGCTCAGCCTC	0.594													20	39	---	---	---	---					
AKAP11	11215	broad.mit.edu	37	13	42882732	42882732	+	Frame_Shift_Del	DEL	C	C	-			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr13:42882732delC	ENST00000025301.2	+	9	5435	c.5260delC	c.(5260-5262)catfs	p.H1754fs		NM_016248.3	NP_057332.1	Q9UKA4	AKA11_HUMAN	A kinase (PRKA) anchor protein 11	1754	Ser-rich.				intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|skin(3)|stomach(2)	56		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		CAGTTTTCATCATCTAAGTGA	0.348													64	196	---	---	---	---					
DNM2	1785	broad.mit.edu	37	19	10887858	10887863	+	In_Frame_Del	DEL	CGTCTT	CGTCTT	-	rs111845811		TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr19:10887858_10887863delCGTCTT	ENST00000314646.5	+	5	818_823	c.654_659delCGTCTT	c.(652-660)gacgtcttg>gag	p.218_220DVL>E	DNM2_ENST00000359692.6_In_Frame_Del_p.218_220DVL>E|DNM2_ENST00000389253.4_In_Frame_Del_p.218_220DVL>E|DNM2_ENST00000591819.1_3'UTR|DNM2_ENST00000585892.1_In_Frame_Del_p.218_220DVL>E|DNM2_ENST00000355667.6_In_Frame_Del_p.218_220DVL>E|DNM2_ENST00000408974.4_In_Frame_Del_p.218_220DVL>E			P50570	DYN2_HUMAN	dynamin 2	218					G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	42			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			ACGCCAGGGACGTCTTGGAGAACAAG	0.592			"""F, N, Splice, Mis, O"""		ETP ALL								20	71	---	---	---	---					
KIZ-AS1	101929591	broad.mit.edu	37	20	21142454	21142455	+	RNA	INS	-	-	C	rs45603533	by1000genomes	TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chr20:21142454_21142455insC	ENST00000591761.1	-	0	5142				PLK1S1_ENST00000457464.1_RNA|RP5-872K7.7_ENST00000425746.2_RNA																							AAAAAAAAAAACCCCACCTAAT	0.376													7	14	---	---	---	---					
KDM6A	7403	broad.mit.edu	37	X	44970638	44970639	+	Frame_Shift_Ins	INS	-	-	C			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chrX:44970638_44970639insC	ENST00000377967.4	+	29	4229_4230	c.4188_4189insC	c.(4189-4191)ccafs	p.P1397fs	KDM6A_ENST00000543216.1_Frame_Shift_Ins_p.P1318fs|KDM6A_ENST00000536777.1_Frame_Shift_Ins_p.P1352fs|KDM6A_ENST00000382899.4_Frame_Shift_Ins_p.P1404fs	NM_021140.2	NP_066963.2	O15550	KDM6A_HUMAN	lysine (K)-specific demethylase 6A	1397					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0?(6)		NS(1)|breast(7)|central_nervous_system(27)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(24)|kidney(24)|large_intestine(9)|liver(1)|lung(21)|oesophagus(11)|pancreas(2)|prostate(5)|skin(1)|soft_tissue(1)|urinary_tract(29)	170						CTCCTCCATTACCATCCGCCTC	0.376			"""D, N, F, S"""		"""renal, oesophageal SCC, MM"""								74	33	---	---	---	---					
DGKK	139189	broad.mit.edu	37	X	50165595	50165596	+	RNA	INS	-	-	AC	rs59226442		TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chrX:50165595_50165596insAC	ENST00000376025.2	-	0	816							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					TTAAAAGGTAAacacacacaca	0.411													6	8	---	---	---	---					
TSIX	9383	broad.mit.edu	37	X	73047124	73047125	+	RNA	DEL	AC	AC	-			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chrX:73047124_73047125delAC	ENST00000604411.1	+	0	35085_35086				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						GCCACACATGACACACACACAC	0.470													7	88	---	---	---	---					
FTX	100302692	broad.mit.edu	37	X	73506653	73506654	+	RNA	INS	-	-	A	rs149262205		TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chrX:73506653_73506654insA	ENST00000429124.1	-	0	174																											acctgtcccttaaaaaaaaaaa	0.455													3	4	---	---	---	---					
PLXNB3	5365	broad.mit.edu	37	X	153039907	153039907	+	Frame_Shift_Del	DEL	C	C	-			TCGA-XF-AAN2-01A-11D-A42E-08	TCGA-XF-AAN2-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	736950d7-b7f1-4217-aff4-91db2a0f19ee	683bcd38-6248-4771-b24e-a22ce5c301d4	g.chrX:153039907delC	ENST00000538966.1	+	23	4051	c.3780delC	c.(3778-3780)ggcfs	p.G1260fs	PLXNB3_ENST00000538776.1_Frame_Shift_Del_p.G890fs|PLXNB3_ENST00000361971.5_Frame_Shift_Del_p.G1237fs|PLXNB3_ENST00000538282.1_Frame_Shift_Del_p.G847fs	NM_001163257.1	NP_001156729.1	Q9ULL4	PLXB3_HUMAN	plexin B3	1237					axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			central_nervous_system(1)|endometrium(7)|large_intestine(2)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	32	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					TGGCCCTGGGCCCTGTGCAGT	0.701													2	4	---	---	---	---