Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
THSD7A	221981	broad.mit.edu	37	7	11582732	11582732	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr7:11582732A>G	ENST00000423059.4	-	5	1717	c.1466T>C	c.(1465-1467)aTg>aCg	p.M489T		NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A		TSP type-1 4.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		TTTTAAGTCCATTGGCTTTGA	0.383000										HNSCC(18;0.044)			20	21					0	0	1	0	0
FTHL17	53940	broad.mit.edu	37	X	31089818	31089818	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chrX:31089818C>A	ENST00000359202.3	-	1	352	c.253G>T	c.(253-255)Gat>Tat	p.D85Y		NM_031894.2	NP_114100.1	Q9BXU8	FHL17_HUMAN	ferritin, heavy polypeptide-like 17	85	Ferritin-like diiron.				cellular iron ion homeostasis|iron ion transport		ferric iron binding|oxidoreductase activity			endometrium(2)|large_intestine(2)|liver(1)|lung(13)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	23						TTCCTGATATCGTGAAGGCAG	0.597000													21	31					2.4624e-09	2.5835e-09	1	1	0
TRGV4	6977	broad.mit.edu	37	7	38393558	38393558	+	RNA	SNP	C	C	T			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr7:38393558C>T	ENST00000390345.2	-	0	445																											CAAGTGATTTCAGCAGATGAC	0.488000													24	6					0	0	1	0	0
WDR70	55100	broad.mit.edu	37	5	37725073	37725073	+	Silent	SNP	G	G	T			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr5:37725073G>T	ENST00000265107.4	+	16	1791	c.1635G>T	c.(1633-1635)cgG>cgT	p.R545R		NM_018034.2	NP_060504.1	Q9NW82	WDR70_HUMAN	WD repeat domain 70	545										central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(5)|lung(18)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_lung(31;0.000285)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CCCGCCAACGGAGTACAAGGA	0.473000													6	113					0.0215528	0.0217225	1	1	0
ZNF93	81931	broad.mit.edu	37	19	20044676	20044676	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr19:20044676G>C	ENST00000343769.5	+	4	940	c.912G>C	c.(910-912)aaG>aaC	p.K304N	AC007204.2_ENST00000592245.1_lincRNA	NM_031218.3	NP_112495.2	P35789	ZNF93_HUMAN	zinc finger protein 93	304						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(6)|kidney(2)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	24						CTAAACATAAGAAAATTCATA	0.368000													29	38					0	0	1	0	0
CSPG4	1464	broad.mit.edu	37	15	75979679	75979679	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr15:75979679G>A	ENST00000308508.5	-	3	3819	c.3727C>T	c.(3727-3729)Cgg>Tgg	p.R1243W		NM_001897.4	NP_001888.2	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4	1243	Gly/Ser-rich (glycosaminoglycan attachment domain).|Interaction with COL5A1 (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			breast(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(3)|liver(2)|lung(18)|ovary(2)|pancreas(2)|prostate(4)|skin(4)	48						TTCTTGTGCCGGACCAGCTTC	0.617000													13	83					0	0	1	0	0
CAPN1	823	broad.mit.edu	37	11	64956166	64956166	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr11:64956166G>T	ENST00000527323.1	+	9	1354	c.1114G>T	c.(1114-1116)Gaa>Taa	p.E372*	CAPN1_ENST00000279247.6_Nonsense_Mutation_p.E372*|CAPN1_ENST00000533820.1_Nonsense_Mutation_p.E372*|CAPN1_ENST00000524773.1_Nonsense_Mutation_p.E372*|CAPN1_ENST00000533129.1_Nonsense_Mutation_p.E372*			P07384	CAN1_HUMAN	calpain 1, (mu/I) large subunit	372	Domain III.				positive regulation of cell proliferation|proteolysis	cytoplasm|plasma membrane	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|protein binding			breast(2)|endometrium(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(1)	13		Lung NSC(402;0.094)|Melanoma(852;0.16)		Lung(977;0.00168)|LUSC - Lung squamous cell carcinoma(976;0.00813)		CACACTCTACGAAGGCACCTG	0.657000													10	5					2.17888e-05	2.26745e-05	1	1	0
PCNT	5116	broad.mit.edu	37	21	47841947	47841947	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr21:47841947C>T	ENST00000359568.5	+	32	7195	c.7088C>T	c.(7087-7089)gCt>gTt	p.A2363V	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	2363					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					GCTCAAACTGCTGGTCCTGTG	0.597000													15	26					0	0	1	0	0
FGFR3	2261	broad.mit.edu	37	4	1806092	1806092	+	Missense_Mutation	SNP	A	A	T	rs121913484		TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr4:1806092A>T	ENST00000340107.4	+	9	1373	c.1117A>T	c.(1117-1119)Agt>Tgt	p.S373C	FGFR3_ENST00000481110.2_Missense_Mutation_p.S371C|FGFR3_ENST00000412135.2_Intron|FGFR3_ENST00000352904.1_Intron|FGFR3_ENST00000260795.2_Missense_Mutation_p.S371C|FGFR3_ENST00000440486.2_Missense_Mutation_p.S371C	NM_001163213.1	NP_001156685.1	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3	371			Y -> C (in KERSEB and TD1).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.S371C(55)		NS(1)|central_nervous_system(5)|cervix(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(40)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(9)|skin(339)|soft_tissue(4)|testis(2)|upper_aerodigestive_tract(58)|urinary_tract(2607)	3091		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	CGAGGCGGGCAGTGTGTATGC	0.682000		1	"""Mis, T"""	"""IGH@, ETV6"""	"""bladder, MM, T-cell lymphoma"""		"""Hypochondroplasia, Thanatophoric dysplasia"""		Saethre-Chotzen syndrome;Muenke syndrome				83	9					0	0	1	0	0
TRIO	7204	broad.mit.edu	37	5	14358374	14358374	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr5:14358374C>T	ENST00000344204.4	+	12	2158	c.2134C>T	c.(2134-2136)Cgc>Tgc	p.R712C	TRIO_ENST00000537187.1_Missense_Mutation_p.R712C|TRIO_ENST00000509967.2_Missense_Mutation_p.R663C	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	712					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					CCTCATCAAGCGCTTTGGCCA	0.632000													18	28					0	0	1	0	0
PAFAH1B3	5050	broad.mit.edu	37	19	42804381	42804381	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr19:42804381C>T	ENST00000538771.1	-	4	583	c.227G>A	c.(226-228)gGc>gAc	p.G76D	PAFAH1B3_ENST00000262890.3_Missense_Mutation_p.G76D	NM_001145939.1|NM_001145940.1	NP_001139411.1|NP_001139412.1	Q15102	PA1B3_HUMAN	platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)	76					lipid catabolic process|nervous system development	cytoplasm	1-alkyl-2-acetylglycerophosphocholine esterase activity|protein binding			breast(1)|large_intestine(2)|ovary(1)	4		Prostate(69;0.0704)				ATGCTGTGTGCCGTCACCACC	0.577000													3	43					0	0	1	0	0
ZNF750	79755	broad.mit.edu	37	17	80790298	80790298	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr17:80790298C>A	ENST00000269394.3	-	2	866	c.33G>T	c.(31-33)aaG>aaT	p.K11N	TBCD_ENST00000539345.2_Intron|TBCD_ENST00000355528.4_Intron|TBCD_ENST00000397466.2_Intron|ZNF750_ENST00000572562.1_Intron	NM_024702.2	NP_078978.2	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	11						intracellular	zinc ion binding			NS(3)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(4)|lung(12)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	31	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			TGTAATGTGGCTTTTTTGGCT	0.478000													18	25					6.49762e-13	7.16979e-13	1	1	0
IKZF1	10320	broad.mit.edu	37	7	50455159	50455159	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr7:50455159C>A	ENST00000331340.3	+	6	861	c.706C>A	c.(706-708)Ctg>Atg	p.L236M	IKZF1_ENST00000349824.4_Intron|IKZF1_ENST00000438033.1_Missense_Mutation_p.L149M|IKZF1_ENST00000440768.2_Intron|IKZF1_ENST00000439701.1_Intron|IKZF1_ENST00000359197.5_Intron|IKZF1_ENST00000346667.4_Intron|IKZF1_ENST00000343574.5_Missense_Mutation_p.L149M|IKZF1_ENST00000357364.4_Intron	NM_001220769.1|NM_001220772.1|NM_001220773.1|NM_001220775.1|NM_006060.4	NP_001207698.1|NP_001207701.1|NP_001207702.1|NP_001207704.1|NP_006051.1	Q13422	IKZF1_HUMAN	IKAROS family zinc finger 1 (Ikaros)	236					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(131)|p.L236V(1)		haematopoietic_and_lymphoid_tissue(275)|lung(1)	276	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				TCCGGGCACACTGTACCCAGG	0.582000			"""D,T"""	BCL6	"""ALL, DLBCL"""								9	9					0.000442599	0.000453222	1	1	0
ALG10	84920	broad.mit.edu	37	12	34179787	34179787	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr12:34179787C>A	ENST00000266483.2	+	3	1678	c.1359C>A	c.(1357-1359)ttC>ttA	p.F453L	RP11-847H18.2_ENST00000501954.2_RNA|ALG10_ENST00000538927.1_Intron	NM_032834.3	NP_116223.3	Q5BKT4	AG10A_HUMAN	ALG10, alpha-1,2-glucosyltransferase	453					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	26	Lung NSC(5;3.82e-05)|Acute lymphoblastic leukemia(23;0.0142)|all_hematologic(23;0.0429)	Lung NSC(34;0.204)|all_lung(34;0.235)				TAACTTTTTTCATCTTTCTGA	0.358000													57	61					8.44121e-28	9.47785e-28	1	1	0
RAVER1	125950	broad.mit.edu	37	19	10431736	10431736	+	Silent	SNP	C	C	T			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr19:10431736C>T	ENST00000293677.6	-	8	1593	c.1512G>A	c.(1510-1512)ccG>ccA	p.P504P		NM_133452.2	NP_597709.2	Q8IY67	RAVR1_HUMAN	ribonucleoprotein, PTB-binding 1	513						cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			breast(1)|endometrium(3)|large_intestine(1)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	18			OV - Ovarian serous cystadenocarcinoma(20;1.81e-09)|Epithelial(33;3.65e-06)|all cancers(31;8.35e-06)			CAGGGGGCGTCGGCAGAGGCC	0.721000													3	4					0	0	1	0	0
CRHR2	1395	broad.mit.edu	37	7	30693204	30693204	+	Missense_Mutation	SNP	C	C	T	rs79671818		TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr7:30693204C>T	ENST00000471646.1	-	12	1525	c.1108G>A	c.(1108-1110)Gtg>Atg	p.V370M	CRHR2_ENST00000341843.4_Missense_Mutation_p.V356M|CRHR2_ENST00000348438.4_Missense_Mutation_p.V397M|CRHR2_ENST00000506074.2_3'UTR	NM_001202482.1|NM_001202483.1|NM_001883.4	NP_001189411.1|NP_001189412.1|NP_001874.2	Q13324	CRFR2_HUMAN	corticotropin releasing hormone receptor 2	370					G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			breast(2)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						CTCTTCCTCACGGCTGAGCGC	0.637000													8	24					0	0	1	0	0
SLC11A1	6556	broad.mit.edu	37	2	219255980	219255980	+	Silent	SNP	C	C	T			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr2:219255980C>T	ENST00000233202.6	+	10	1354	c.1014C>T	c.(1012-1014)aaC>aaT	p.N338N	SLC11A1_ENST00000539932.1_Silent_p.N220N	NM_000578.3	NP_000569.3	P49279	NRAM1_HUMAN	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1	338					activation of protein kinase activity|antigen processing and presentation of peptide antigen|cadmium ion transmembrane transport|cellular cadmium ion homeostasis|cellular iron ion homeostasis|defense response to Gram-negative bacterium|defense response to protozoan|divalent metal ion export|inflammatory response|interleukin-2 production|interleukin-3 production|iron ion transport|L-arginine import|macrophage activation|MHC class II biosynthetic process|mRNA stabilization|multicellular organismal iron ion homeostasis|negative regulation of cytokine production|nitrite transport|phagocytosis|positive regulation of dendritic cell antigen processing and presentation|positive regulation of interferon-gamma production|positive regulation of phagocytosis|positive regulation of T-helper 1 type immune response|positive regulation of transcription from RNA polymerase II promoter|respiratory burst|response to interferon-gamma|response to lipopolysaccharide|T cell cytokine production|T cell proliferation involved in immune response|vacuolar acidification|wound healing	integral to plasma membrane|late endosome membrane|lysosome|phagocytic vesicle membrane|tertiary granule membrane	manganese ion transmembrane transporter activity|metal ion:hydrogen antiporter activity|protein homodimerization activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	19		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000195)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCATGAACAACGCCACCGTGG	0.632000													9	17					0	0	1	0	0
CENPM	79019	broad.mit.edu	37	22	42341967	42341967	+	Silent	SNP	C	C	T			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr22:42341967C>T	ENST00000402338.1	-	2	319	c.78G>A	c.(76-78)cgG>cgA	p.R26R	CENPM_ENST00000404067.1_Silent_p.R26R|CENPM_ENST00000215980.5_Silent_p.R60R|CENPM_ENST00000407253.3_Silent_p.R60R|CENPM_ENST00000402420.1_Silent_p.R26R			Q9NSP4	CENPM_HUMAN	centromere protein M	60					mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleus				kidney(1)|large_intestine(1)|prostate(1)	3						CAATTCGGGGCCGATTCACAC	0.542000													8	10					0	0	1	0	0
TRIB2	28951	broad.mit.edu	37	2	12880461	12880461	+	Silent	SNP	C	C	T			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr2:12880461C>T	ENST00000155926.4	+	3	1992	c.573C>T	c.(571-573)gtC>gtT	p.V191V	TRIB2_ENST00000381465.2_Silent_p.V55V	NM_021643.3	NP_067675.1	Q92519	TRIB2_HUMAN	tribbles pseudokinase 2	191	Protein kinase.				negative regulation of fat cell differentiation|negative regulation of interleukin-10 biosynthetic process|negative regulation of protein kinase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of MAP kinase activity	cytoplasm|cytoskeleton|nucleus	ATP binding|protein kinase activity|protein kinase inhibitor activity|transcription factor binding|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(8)|lung(5)|prostate(1)|skin(1)|stomach(1)	19	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					GGACTCGGGTCAAGCTGGAAA	0.512000													29	35					0	0	1	0	0
NUTM2B-AS1	101060691	broad.mit.edu	37	10	81444997	81444997	+	RNA	SNP	T	T	C			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr10:81444997T>C	ENST00000600376.1	-	0	54				RP11-119F19.2_ENST00000596088.1_RNA																							ACAACAATTTTCGGGCTTGCA	0.612000													3	5					0	0	1	0	0
PIGG	54872	broad.mit.edu	37	4	520828	520828	+	Splice_Site	SNP	C	C	T			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr4:520828C>T	ENST00000453061.2	+	10	2176	c.2070C>T	c.(2068-2070)agC>agT	p.S690S	PIGG_ENST00000504346.1_Splice_Site_p.S601S|PIGG_ENST00000310340.5_Splice_Site_p.S682S|PIGG_ENST00000383028.4_Splice_Site_p.S557S|PIGG_ENST00000296306.7_3'UTR	NM_001127178.1	NP_001120650.1	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class G	690					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(16)|ovary(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	39						CTCATTTCAGCTCTGACCACA	0.498000													4	11					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78321172	78321172	+	Missense_Mutation	SNP	A	A	T			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr17:78321172A>T	ENST00000582970.1	+	29	9180	c.9037A>T	c.(9037-9039)Agc>Tgc	p.S3013C	RNF213_ENST00000508628.2_Missense_Mutation_p.S3062C|RNF213_ENST00000336301.6_Missense_Mutation_p.S1086C	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			AGAGGAAGTCAGCCCCATGCA	0.537000													14	15					0	0	1	0	0
ANKRD26	22852	broad.mit.edu	37	10	27303613	27303613	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr10:27303613C>G	ENST00000376087.4	-	31	4699	c.4534G>C	c.(4534-4536)Gag>Cag	p.E1512Q	ANKRD26_ENST00000436985.2_Missense_Mutation_p.E1528Q|ANKRD26_ENST00000376070.3_Missense_Mutation_p.E1069Q	NM_001256053.1|NM_014915.2	NP_001242982.1|NP_055730.2	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	1511						centrosome				breast(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|urinary_tract(2)	70						CTAAACTGCTCTAAGTTTTCT	0.333000													13	28					0	0	1	0	0
ZIC4	84107	broad.mit.edu	37	3	147108850	147108850	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr3:147108850G>A	ENST00000383075.3	-	4	1384	c.872C>T	c.(871-873)tCg>tTg	p.S291L	ZIC4_ENST00000484399.1_Missense_Mutation_p.S291L|ZIC4_ENST00000473123.1_Missense_Mutation_p.S291L|ZIC4_ENST00000525172.2_Missense_Mutation_p.S341L|ZIC4_ENST00000425731.3_Missense_Mutation_p.S329L|ZIC4_ENST00000491672.1_Missense_Mutation_p.S85L|ZIC4_ENST00000472749.2_5'UTR	NM_032153.5	NP_115529.2	Q8N9L1	ZIC4_HUMAN	Zic family member 4	291						nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(34)|upper_aerodigestive_tract(4)	57						GGGCGGCGGCGAGCGCCCGTG	0.672000													27	23					0	0	1	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128839534	128839534	+	Silent	SNP	G	G	A			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr11:128839534G>A	ENST00000310343.9	-	22	5531	c.5532C>T	c.(5530-5532)ggC>ggT	p.G1844G	ARHGAP32_ENST00000527272.1_Silent_p.G1495G|ARHGAP32_ENST00000392657.3_Silent_p.G1495G|ARHGAP32_ENST00000524655.1_3'UTR	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	1844	Interaction with FYN.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						TGCTACCATGGCCTCCGTGAT	0.617000													14	18					0	0	1	0	0
PRR11	55771	broad.mit.edu	37	17	57270934	57270934	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr17:57270934G>A	ENST00000262293.4	+	5	796	c.484G>A	c.(484-486)Gtt>Att	p.V162I		NM_018304.3	NP_060774.2	Q96HE9	PRR11_HUMAN	proline rich 11	162										breast(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|pancreas(1)	16	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					GCCTGCCTGCGTTCTGATCAC	0.527000													20	26					0	0	1	0	0
FSTL5	56884	broad.mit.edu	37	4	162697158	162697158	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr4:162697158A>G	ENST00000306100.5	-	5	914	c.478T>C	c.(478-480)Tat>Cat	p.Y160H	FSTL5_ENST00000379164.4_Missense_Mutation_p.Y159H|FSTL5_ENST00000427802.2_Missense_Mutation_p.Y159H|FSTL5_ENST00000536695.1_Missense_Mutation_p.Y159H	NM_001128427.2|NM_020116.4	NP_001121899.1|NP_064501.2	Q8N475	FSTL5_HUMAN	follistatin-like 5	160						extracellular region	calcium ion binding			central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(18)|lung(43)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	91	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		TGCATAATATATTTTTGATTT	0.308000													8	25					0	0	1	0	0
PCDHA12	56137	broad.mit.edu	37	5	140256915	140256915	+	Missense_Mutation	SNP	A	A	T			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr5:140256915A>T	ENST00000398631.2	+	1	1858	c.1858A>T	c.(1858-1860)Atc>Ttc	p.I620F	PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA6_ENST00000529310.1_Intron	NM_018903.2|NM_031864.2	NP_061726.1|NP_114070.1														NS(4)|breast(2)|cervix(1)|endometrium(19)|kidney(8)|large_intestine(8)|liver(2)|lung(25)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGCGCGCACATCCCGTTCCA	0.672000													33	44					0	0	1	0	0
ST8SIA2	8128	broad.mit.edu	37	15	93007522	93007522	+	Silent	SNP	G	G	A			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr15:93007522G>A	ENST00000268164.3	+	6	1272	c.1035G>A	c.(1033-1035)ccG>ccA	p.P345P	ST8SIA2_ENST00000539113.1_Silent_p.P324P	NM_006011.3	NP_006002.1	Q92186	SIA8B_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	345					axon guidance|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			endometrium(2)|large_intestine(6)|lung(9)|skin(2)|urinary_tract(1)	20	Lung NSC(78;0.0893)|all_lung(78;0.125)		BRCA - Breast invasive adenocarcinoma(143;0.0355)|OV - Ovarian serous cystadenocarcinoma(32;0.203)			AGGCCAGCCCGCATACCATGC	0.572000													5	89					0	0	1	0	0
HLA-A	3105	broad.mit.edu	37	6	29911264	29911264	+	Missense_Mutation	SNP	G	G	A	rs41552712		TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr6:29911264G>A	ENST00000396634.1	+	5	904	c.563G>A	c.(562-564)tGc>tAc	p.C188Y	HLA-A_ENST00000376802.2_Missense_Mutation_p.C188Y|HLA-A_ENST00000376806.5_Missense_Mutation_p.C188Y|HLA-A_ENST00000376809.5_Missense_Mutation_p.C188Y			P30443	1A01_HUMAN	major histocompatibility complex, class I, A	188	Alpha-2.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity			central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	30						GATGGCACGTGCGTGGAGTGG	0.667000									Osteosarcoma, Familial Clustering of;Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of;Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of	Multiple Myeloma(9;0.094)			24	19					0	0	1	0	0
AMPD1	270	broad.mit.edu	37	1	115218586	115218586	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr1:115218586C>A	ENST00000369538.3	-	10	1561	c.1514G>T	c.(1513-1515)gGa>gTa	p.G505V	AMPD1_ENST00000520113.2_Missense_Mutation_p.G509V|AMPD1_ENST00000353928.6_Missense_Mutation_p.G476V	NM_001172626.1	NP_001166097.1	P23109	AMPD1_HUMAN	adenosine monophosphate deaminase 1	476					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(3)|pancreas(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	45	all_epithelial(7;7.83e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Adenosine monophosphate(DB00131)	CAGCATTTTTCCAAAATGTGG	0.433000													36	53					2.04263e-09	2.1608e-09	1	1	0
PDS5A	23244	broad.mit.edu	37	4	39851142	39851142	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr4:39851142C>T	ENST00000303538.8	-	27	3756	c.3217G>A	c.(3217-3219)Gaa>Aaa	p.E1073K		NM_001100399.1	NP_001093869.1	Q29RF7	PDS5A_HUMAN	PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)	1073					cell division|mitosis|negative regulation of DNA replication	chromatin|nucleus	identical protein binding			breast(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(9)|lung(14)|prostate(3)|skin(1)|urinary_tract(1)	39						CATCTTACTTCATTTGTCTTG	0.358000													16	28					0	0	1	0	0
CD300E	342510	broad.mit.edu	37	17	72608881	72608881	+	Missense_Mutation	SNP	C	C	T	rs113824696		TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr17:72608881C>T	ENST00000392619.1	-	4	645	c.610G>A	c.(610-612)Gtg>Atg	p.V204M	CD300E_ENST00000426295.2_Missense_Mutation_p.V218M|CD300E_ENST00000328630.3_Missense_Mutation_p.V177M	NM_181449.2	NP_852114.2	Q496F6	CLM2_HUMAN	CD300e molecule	177						integral to membrane|plasma membrane	receptor activity			breast(1)|kidney(3)|large_intestine(4)|lung(4)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	19						AGAAGGACCACGAGCAGGAAG	0.612000													25	33					0	0	1	0	0
PSMB2	5690	broad.mit.edu	37	1	36068948	36068948	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr1:36068948G>A	ENST00000373237.3	-	6	937	c.526C>T	c.(526-528)Cca>Tca	p.P176S		NM_002794.4	NP_002785.1	P49721	PSB2_HUMAN	proteasome (prosome, macropain) subunit, beta type, 2	176					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity			endometrium(1)|large_intestine(2)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)			Bortezomib(DB00188)	CTGAAGGTTGGCAGATTCAGG	0.458000													12	19					0	0	1	0	0
INTS6	26512	broad.mit.edu	37	13	51943210	51943210	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr13:51943210C>G	ENST00000311234.4	-	16	2813	c.2341G>C	c.(2341-2343)Gaa>Caa	p.E781Q	INTS6_ENST00000463928.1_3'UTR|INTS6_ENST00000425000.1_Missense_Mutation_p.E349Q|INTS6_ENST00000490542.1_Missense_Mutation_p.E465Q|INTS6_ENST00000398119.2_Missense_Mutation_p.E768Q|INTS6_ENST00000497989.1_Missense_Mutation_p.E603Q	NM_012141.2	NP_036273.1	Q9UL03	INT6_HUMAN	integrator complex subunit 6	781					snRNA processing	actin cytoskeleton|integrator complex	protein binding|transmembrane receptor activity			NS(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(10)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31		Breast(56;0.000286)|Lung NSC(96;0.00145)|Prostate(109;0.00403)|Hepatocellular(98;0.065)|Myeloproliferative disorder(33;0.163)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;7.7e-08)		GCACATTGTTCTTTATCTCTT	0.408000													45	53					0	0	1	0	0
SLC9A6	10479	broad.mit.edu	37	X	135126623	135126623	+	Silent	SNP	T	T	C			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chrX:135126623T>C	ENST00000370695.4	+	16	1881	c.1846T>C	c.(1846-1848)Ttg>Ctg	p.L616L	SLC9A6_ENST00000370701.1_Silent_p.L564L|SLC9A6_ENST00000370698.3_Silent_p.L584L	NM_001042537.1	NP_001036002.1	Q92581	SL9A6_HUMAN	solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6	584					regulation of pH	early endosome membrane|endoplasmic reticulum membrane|integral to membrane|microsome|plasma membrane|recycling endosome membrane	sodium:hydrogen antiporter activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(18)|ovary(2)|upper_aerodigestive_tract(1)	33	Acute lymphoblastic leukemia(192;0.000127)					CCAGGAACAGTTGAAAGATGA	0.383000													15	17					0	0	1	0	0
CPS1	1373	broad.mit.edu	37	2	211540510	211540510	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr2:211540510C>T	ENST00000233072.5	+	36	4416	c.4220C>T	c.(4219-4221)cCa>cTa	p.P1407L	CPS1_ENST00000451903.2_Missense_Mutation_p.P956L|CPS1_ENST00000430249.2_Missense_Mutation_p.P1413L	NM_001875.4	NP_001866.2	P31327	CPSM_HUMAN	carbamoyl-phosphate synthase 1, mitochondrial	1407					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(85)|ovary(8)|pancreas(1)|prostate(6)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	142				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		CCTGCCACCCCAGTGGCATGG	0.443000													15	14					0	0	1	0	0
LOC645752	645752	broad.mit.edu	37	15	78212571	78212571	+	RNA	SNP	G	G	A			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr15:78212571G>A	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							CCTGTGTCACGTGTGCGTTCA	0.572000													4	57					0	0	1	0	0
NPIPA8	101059953	broad.mit.edu	37	16	18434447	18434447	+	Translation_Start_Site	SNP	C	C	A			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr16:18434447C>A	ENST00000339303.5	-	0	1856									nuclear pore complex interacting protein family, member A8																		GGCGGGGGCCCTGCTGAAAGC	0.627000													14	0					4.14922e-12	4.50085e-12	1	1	0
MLLT3	4300	broad.mit.edu	37	9	20414346	20414346	+	Silent	SNP	G	G	A			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr9:20414346G>A	ENST00000380338.4	-	5	784	c.498C>T	c.(496-498)agC>agT	p.S166S	MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S163S	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	166	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S166S(4)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctactgctgctgctgc	0.527000			T	MLL	ALL								5	40					0	0	1	0	0
DIDO1	11083	broad.mit.edu	37	20	61512313	61512313	+	Silent	SNP	G	G	A			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr20:61512313G>A	ENST00000266070.4	-	16	5320	c.4995C>T	c.(4993-4995)tgC>tgT	p.C1665C	DIDO1_ENST00000395343.1_Silent_p.C1665C	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	1665					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					GCAGGGCGCCGCAAGGCGGTG	0.731000													3	24					0	0	1	0	0
CASP10	843	broad.mit.edu	37	2	202070617	202070617	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr2:202070617C>G	ENST00000286186.6	+	7	1169	c.734C>G	c.(733-735)aCa>aGa	p.T245R	CASP10_ENST00000313728.7_Intron|CASP10_ENST00000448480.1_Intron|CASP10_ENST00000272879.5_Missense_Mutation_p.T245R|CASP10_ENST00000492363.1_Intron|CASP10_ENST00000346817.5_Intron|CASP10_ENST00000360132.3_Intron	NM_032977.3	NP_116759.2	Q92851	CASPA_HUMAN	caspase 10, apoptosis-related cysteine peptidase	245					apoptosis|induction of apoptosis by extracellular signals|proteolysis	cytosol|plasma membrane	cysteine-type endopeptidase activity|identical protein binding|protein binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	27						AACAGAGCCACAAATGGTGCA	0.433000													11	15					0	0	1	0	0
TNFSF9	8744	broad.mit.edu	37	19	6534930	6534930	+	Silent	SNP	G	G	C			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr19:6534930G>C	ENST00000245817.3	+	3	656	c.618G>C	c.(616-618)ctG>ctC	p.L206L		NM_003811.3	NP_003802.1	P41273	TNFL9_HUMAN	tumor necrosis factor (ligand) superfamily, member 9	206					apoptosis|cell proliferation|cell-cell signaling|immune response|signal transduction	extracellular space|integral to membrane	cytokine activity|tumor necrosis factor receptor binding			central_nervous_system(1)|lung(1)|ovary(1)|prostate(1)|skin(1)	5						TGCTGCACCTGAGTGCCGGCC	0.697000													5	13					0	0	1	0	0
TREH	11181	broad.mit.edu	37	11	118534104	118534104	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr11:118534104G>A	ENST00000529101.1	-	2	179	c.134C>T	c.(133-135)gCc>gTc	p.A45V	TREH_ENST00000264029.4_Missense_Mutation_p.A45V|TREH_ENST00000525958.1_Missense_Mutation_p.A45V|TREH_ENST00000530256.1_Intron|TREH_ENST00000397925.1_Missense_Mutation_p.A45V			O43280	TREA_HUMAN	trehalase (brush-border membrane glycoprotein)	45					polysaccharide digestion|trehalose catabolic process	anchored to plasma membrane	alpha,alpha-trehalase activity			NS(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(3)|ovary(1)|pancreas(1)|urinary_tract(1)	13	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.0564)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.16e-05)		GTAGAGCTTGGCCATTTGAAC	0.532000													10	5					0	0	1	0	0
CDC25A	993	broad.mit.edu	37	3	48226163	48226163	+	Silent	SNP	C	C	T			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr3:48226163C>T	ENST00000302506.3	-	3	678	c.270G>A	c.(268-270)ggG>ggA	p.G90G	CDC25A_ENST00000351231.3_Silent_p.G90G	NM_001789.2	NP_001780.2	P30304	MPIP1_HUMAN	cell division cycle 25A	90					cell cycle checkpoint|cell division|cell proliferation|cellular response to UV|DNA replication|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle	cytosol|nucleoplasm	protein binding|protein tyrosine phosphatase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(9)|prostate(1)|skin(1)	20				BRCA - Breast invasive adenocarcinoma(193;0.000685)|KIRC - Kidney renal clear cell carcinoma(197;0.00596)|Kidney(197;0.00684)		TGTCCAATGGCCCAGGAGAAT	0.284000													6	21					0	0	1	0	0
CHRM5	1133	broad.mit.edu	37	15	34356162	34356162	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr15:34356162C>T	ENST00000383263.5	+	3	1914	c.1244C>T	c.(1243-1245)aCg>aTg	p.T415M	CHRM5_ENST00000557872.1_Missense_Mutation_p.T415M	NM_012125.3	NP_036257.1	P08912	ACM5_HUMAN	cholinergic receptor, muscarinic 5	415					cell proliferation|inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signaling pathway	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|skin(1)	20		all_lung(180;1.76e-08)		all cancers(64;4.82e-17)|GBM - Glioblastoma multiforme(113;2.58e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0262)	Atropine(DB00572)|Benzquinamide(DB00767)|Cryptenamine(DB00785)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Thiethylperazine(DB00372)	GAACCTTCAACGAAAGGCCTC	0.522000													11	61					0	0	1	0	0
TTC17	55761	broad.mit.edu	37	11	43471655	43471655	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr11:43471655C>T	ENST00000039989.4	+	20	2824	c.2810C>T	c.(2809-2811)gCc>gTc	p.A937V		NM_018259.5	NP_060729.2	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17	937							binding			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(27)|ovary(5)|prostate(3)|skin(3)	53						ATAGATTTTGCCACCCCTATA	0.473000													4	87					0	0	1	0	0
GALC	2581	broad.mit.edu	37	14	88411995	88411995	+	Silent	SNP	G	G	A			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr14:88411995G>A	ENST00000261304.2	-	14	1678	c.1572C>T	c.(1570-1572)ggC>ggT	p.G524G	GALC_ENST00000393568.4_Silent_p.G501G|GALC_ENST00000544807.2_Silent_p.G468G|GALC_ENST00000393569.2_Silent_p.G498G	NM_000153.3|NM_001201401.1	NP_000144.2|NP_001188330.1	P54803	GALC_HUMAN	galactosylceramidase	524					carbohydrate metabolic process|galactosylceramide catabolic process	lysosome	cation binding|galactosylceramidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						AGTGATGCTCGCCAGGGTCTT	0.408000													34	44					0	0	1	0	0
NALCN	259232	broad.mit.edu	37	13	101756675	101756675	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr13:101756675C>G	ENST00000251127.6	-	25	2941	c.2860G>C	c.(2860-2862)Ggt>Cgt	p.G954R		NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	954						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					ATTACTCCACCGAAGTCCCTG	0.348000													26	38					0	0	1	0	0
PALMD	54873	broad.mit.edu	37	1	100154787	100154787	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr1:100154787C>T	ENST00000263174.4	+	7	1346	c.971C>T	c.(970-972)cCg>cTg	p.P324L	PALMD_ENST00000605497.1_Missense_Mutation_p.P324L	NM_017734.4	NP_060204.1	Q9NP74	PALMD_HUMAN	palmdelphin	324					regulation of cell shape	cytoplasm|membrane				central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(8)|ovary(6)|pancreas(1)|prostate(2)	31		all_epithelial(167;0.000813)|all_lung(203;0.0214)|Lung NSC(277;0.0216)		Epithelial(280;0.067)|all cancers(265;0.117)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)		AGTCCCATTCCGCCAGTGCCT	0.453000													24	24					0	0	1	0	0
ZNF93	81931	broad.mit.edu	37	19	20044928	20044928	+	Missense_Mutation	SNP	G	G	C	rs140935689	byFrequency	TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr19:20044928G>C	ENST00000343769.5	+	4	1192	c.1164G>C	c.(1162-1164)aaG>aaC	p.K388N	AC007204.2_ENST00000592245.1_lincRNA	NM_031218.3	NP_112495.2	P35789	ZNF93_HUMAN	zinc finger protein 93	388						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(6)|kidney(2)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	24						CTAGACATAAGAGAGTTCATA	0.403000													24	37					0	0	1	0	0
DOK1	1796	broad.mit.edu	37	2	74781882	74781882	+	Translation_Start_Site	SNP	A	A	G			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr2:74781882A>G	ENST00000233668.5	+	1	670	c.1A>G	c.(1-3)Atg>Gtg	p.M1V	DOK1_ENST00000409429.1_Intron|DOK1_ENST00000480318.1_3'UTR|DOK1_ENST00000340004.6_Start_Codon_SNP_p.M1V	NM_001381.3	NP_001372.1	Q99704	DOK1_HUMAN	docking protein 1, 62kDa (downstream of tyrosine kinase 1)	1				MDGAVMEGPLFLQSQRFGTK -> RLPAQASATREREPRWS PFQ (in Ref. 3; AAB88182).	fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	cytosol|perinuclear region of cytoplasm	insulin receptor binding			endometrium(3)|large_intestine(2)|liver(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16						GCCGGGGGCCATGGACGGAGC	0.682000													13	9					0	0	1	0	0
SPTAN1	6709	broad.mit.edu	37	9	131395609	131395609	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr9:131395609A>G	ENST00000372739.3	+	57	7540	c.7430A>G	c.(7429-7431)aAc>aGc	p.N2477S	SPTAN1_ENST00000358161.5_Missense_Mutation_p.N2477S|SPTAN1_ENST00000372731.4_Missense_Mutation_p.N2472S	NM_001130438.2	NP_001123910.1	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	2472					actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			NS(2)|breast(8)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(21)|liver(1)|lung(25)|ovary(5)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	87						CTTTTCGTGAACTGAGCCACT	0.617000													18	3					0	0	1	0	0
INF2	64423	broad.mit.edu	37	14	105174267	105174267	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr14:105174267C>T	ENST00000392634.4	+	8	1775	c.1663C>T	c.(1663-1665)Cgg>Tgg	p.R555W	INF2_ENST00000330634.7_Missense_Mutation_p.R555W	NM_022489.3	NP_071934.3	Q27J81	INF2_HUMAN	inverted formin, FH2 and WH2 domain containing	555	FH2.				actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding			large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		CCCCAGCCATCGGCGGGTGAA	0.662000													6	20					0	0	1	0	0
NOX4	50507	broad.mit.edu	37	11	89135536	89135536	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr11:89135536C>A	ENST00000535633.1	-	9	1042	c.732G>T	c.(730-732)aaG>aaT	p.K244N	NOX4_ENST00000527626.1_Missense_Mutation_p.K102N|NOX4_ENST00000343727.5_Missense_Mutation_p.K244N|NOX4_ENST00000531342.1_Intron|NOX4_ENST00000542487.1_Missense_Mutation_p.K244N|NOX4_ENST00000375979.3_Intron|NOX4_ENST00000424319.1_Missense_Mutation_p.K244N|NOX4_ENST00000525196.1_Intron|NOX4_ENST00000413594.2_Missense_Mutation_p.K289N|NOX4_ENST00000263317.4_Missense_Mutation_p.K268N|NOX4_ENST00000534731.1_Missense_Mutation_p.K268N|NOX4_ENST00000528341.1_Missense_Mutation_p.K243N|NOX4_ENST00000527956.1_Missense_Mutation_p.K244N|NOX4_ENST00000532825.1_Missense_Mutation_p.K244N	NM_001143836.1|NM_016931.3	NP_001137308.1|NP_058627.1	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4	268	Ferric oxidoreductase.				cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(20)|ovary(2)|prostate(3)|skin(2)	44		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				CCATACAAATCTTCACAAATT	0.368000													18	29					1.01871e-10	1.09576e-10	1	1	0
CASD1	64921	broad.mit.edu	37	7	94166999	94166999	+	Silent	SNP	G	G	A			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr7:94166999G>A	ENST00000297273.4	+	9	1346	c.1059G>A	c.(1057-1059)aaG>aaA	p.K353K		NM_022900.4	NP_075051.4	Q96PB1	CASD1_HUMAN	CAS1 domain containing 1	353						integral to membrane				NS(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(13)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	31	all_cancers(62;6.71e-10)|all_epithelial(64;5e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			GAGAGGAAAAGAAAAATATTA	0.328000													28	43					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98529037	98529037	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr7:98529037G>A	ENST00000359863.4	+	26	3810	c.3601G>A	c.(3601-3603)Ggg>Agg	p.G1201R	TRRAP_ENST00000355540.3_Missense_Mutation_p.G1201R|TRRAP_ENST00000446306.3_Missense_Mutation_p.G1200R	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	1201					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			GGTTTCCAATGGGGCAGTCGC	0.562000													14	17					0	0	1	0	0
HIF3A	64344	broad.mit.edu	37	19	46815896	46815896	+	Silent	SNP	C	C	T			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr19:46815896C>T	ENST00000339613.2	+	8	1098	c.843C>T	c.(841-843)gtC>gtT	p.V281V	HIF3A_ENST00000244303.6_Silent_p.V268V|HIF3A_ENST00000377670.4_Silent_p.V337V|HIF3A_ENST00000600383.1_Silent_p.V268V|HIF3A_ENST00000472815.1_Silent_p.V268V|HIF3A_ENST00000300862.3_Silent_p.V335V|HIF3A_ENST00000420102.2_Silent_p.V286V			Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit	337	PAS 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(14)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	33		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		TCGTCTGTGTCCATTTTTTAA	0.607000													11	39					0	0	1	0	0
BVES	11149	broad.mit.edu	37	6	105548988	105548988	+	Silent	SNP	T	T	C			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr6:105548988T>C	ENST00000314641.5	-	8	1275	c.1059A>G	c.(1057-1059)acA>acG	p.T353T	BVES_ENST00000446408.2_Silent_p.T353T|BVES_ENST00000336775.5_Silent_p.T353T	NM_001199563.1	NP_001186492.1	Q8NE79	POPD1_HUMAN	blood vessel epicardial substance	353					epithelial cell-cell adhesion|muscle organ development|positive regulation of locomotion|positive regulation of receptor recycling|regulation of Cdc42 GTPase activity|regulation of cell shape|regulation of Rac GTPase activity|substrate adhesion-dependent cell spreading|vesicle-mediated transport	integral to membrane|lateral plasma membrane|tight junction	structural molecule activity			NS(2)|large_intestine(6)|lung(9)|prostate(2)|skin(1)|urinary_tract(1)	21		all_cancers(87;2.83e-05)|Acute lymphoblastic leukemia(125;1.95e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0101)|Colorectal(196;0.204)|Lung NSC(302;0.238)				GGACTTTCAATGTATTTGGAG	0.453000													34	32					0	0	1	0	0
GOLGB1	2804	broad.mit.edu	37	3	121409621	121409621	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr3:121409621C>G	ENST00000393667.3	-	14	8700	c.8590G>C	c.(8590-8592)Gag>Cag	p.E2864Q	GOLGB1_ENST00000340645.5_Missense_Mutation_p.E2859Q	NM_001256486.1	NP_001243415.1	Q14789	GOGB1_HUMAN	golgin B1	2859					Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(2)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(26)|liver(2)|lung(36)|ovary(7)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(13)	119				GBM - Glioblastoma multiforme(114;0.0989)		TTCCCTTCCTCTGACTTTCGA	0.463000													9	18					0	0	1	0	0
CSPG4	1464	broad.mit.edu	37	15	75981730	75981730	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr15:75981730T>C	ENST00000308508.5	-	3	1768	c.1676A>G	c.(1675-1677)cAt>cGt	p.H559R		NM_001897.4	NP_001888.2	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4	559	Globular or compact configuration stabilized by disulfide bonds.|Neurite growth inhibition (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			breast(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(3)|liver(2)|lung(18)|ovary(2)|pancreas(2)|prostate(4)|skin(4)	48						GAGGCTGCCATGTGGGAAGAT	0.612000													27	16					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89390571	89390571	+	Silent	SNP	G	G	A			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr15:89390571G>A	ENST00000439576.2	+	8	1901	c.1527G>A	c.(1525-1527)tcG>tcA	p.S509S	ACAN_ENST00000559004.1_Silent_p.S509S|ACAN_ENST00000352105.7_Silent_p.S509S|ACAN_ENST00000561243.1_Silent_p.S509S|ACAN_ENST00000558207.1_Silent_p.S509S	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	509					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			TCATTGCCTCGCCGGAGCAGC	0.687000													5	8					0	0	1	0	0
CELSR3	1951	broad.mit.edu	37	3	48699002	48699002	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr3:48699002C>T	ENST00000544264.1	-	1	1346	c.1066G>A	c.(1066-1068)Gag>Aag	p.E356K	CELSR3_ENST00000164024.4_Missense_Mutation_p.E356K			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	356	Cadherin 1.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CGCCCGGCCTCGCCGGCGTCC	0.672000													31	34					0	0	1	0	0
CHD8	57680	broad.mit.edu	37	14	21861379	21861379	+	Silent	SNP	C	C	T			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr14:21861379C>T	ENST00000399982.2	-	32	6418	c.6354G>A	c.(6352-6354)gaG>gaA	p.E2118E	CHD8_ENST00000430710.3_Silent_p.E1839E|CHD8_ENST00000557364.1_Silent_p.E2118E	NM_001170629.1	NP_001164100.1	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	2118					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(33)|ovary(6)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	85	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		ACAGGAGACTCTCTTCATCAT	0.448000													14	15					0	0	1	0	0
KLHDC4	54758	broad.mit.edu	37	16	87782320	87782320	+	Silent	SNP	G	G	C			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr16:87782320G>C	ENST00000270583.5	-	5	523	c.465C>G	c.(463-465)ctC>ctG	p.L155L	KLHDC4_ENST00000353170.5_Silent_p.L98L|KLHDC4_ENST00000347925.5_Silent_p.L155L	NM_017566.3	NP_060036.2	Q8TBB5	KLDC4_HUMAN	kelch domain containing 4	155			L -> V (in dbSNP:rs3751727).							breast(2)|endometrium(3)|lung(10)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(2)	21				BRCA - Breast invasive adenocarcinoma(80;0.0283)		GCAGGACCCAGAGATCCTTGT	0.562000													54	74					0	0	1	0	0
KIF1A	547	broad.mit.edu	37	2	241710404	241710404	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr2:241710404G>A	ENST00000498729.2	-	15	1571	c.1325C>T	c.(1324-1326)gCc>gTc	p.A442V	KIF1A_ENST00000320389.7_Missense_Mutation_p.A433V	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	433					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		TCTTTCAATGGCCTCCTCGCT	0.652000													18	4					0	0	1	0	0
GPR128	84873	broad.mit.edu	37	3	100364838	100364838	+	Silent	SNP	C	C	T			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr3:100364838C>T	ENST00000273352.3	+	9	1264	c.996C>T	c.(994-996)ttC>ttT	p.F332F	GPR128_ENST00000475887.1_Silent_p.F37F	NM_032787.2	NP_116176.2	Q96K78	GP128_HUMAN	G protein-coupled receptor 128	332					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|liver(2)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	56						ACAAGCTTTTCCAATCAAAAA	0.333000													23	20					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75086459	75086459	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr1:75086459C>A	ENST00000326665.5	-	8	1177	c.959G>T	c.(958-960)gGg>gTg	p.G320V	C1orf173_ENST00000420661.2_Missense_Mutation_p.G123V|RP4-612J11.1_ENST00000416017.1_RNA	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	320										NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						AAGGTTTTCCCCACCACAGTG	0.368000													19	43					3.51602e-12	3.84658e-12	1	1	0
CXorf57	55086	broad.mit.edu	37	X	105921470	105921470	+	Silent	SNP	T	T	C			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chrX:105921470T>C	ENST00000372548.4	+	14	2659	c.2550T>C	c.(2548-2550)agT>agC	p.S850S	CXorf57_ENST00000372544.2_Silent_p.S753S	NM_018015.5	NP_060485.4	Q6NSI4	CX057_HUMAN	chromosome X open reading frame 57	850										NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(5)|large_intestine(6)|lung(11)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	31						AGATTTATAGTCCAGAGAATA	0.323000													42	50					0	0	1	0	0
OR6T1	219874	broad.mit.edu	37	11	123814145	123814145	+	Missense_Mutation	SNP	G	G	T	rs145832379	byFrequency	TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr11:123814145G>T	ENST00000321252.2	-	1	435	c.401C>A	c.(400-402)aCc>aAc	p.T134N		NM_001005187.1	NP_001005187.1	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T, member 1	134					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		ATTCATCAGGGTCTCATAGCG	0.557000													6	12					0.00198382	0.00201531	1	1	0
JPH3	57338	broad.mit.edu	37	16	87723611	87723611	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr16:87723611G>A	ENST00000284262.2	+	4	1887	c.1645G>A	c.(1645-1647)Ggc>Agc	p.G549S	JPH3_ENST00000563609.1_3'UTR	NM_020655.2	NP_065706.2	Q8WXH2	JPH3_HUMAN	junctophilin 3	549					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(80;0.0287)		TGCCCTGCGCGGCGGCCTGCT	0.761000													6	1					0	0	1	0	0
ABCB7	22	broad.mit.edu	37	X	74273275	74273275	+	Missense_Mutation	SNP	T	T	A			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chrX:74273275T>A	ENST00000253577.3	-	16	2216	c.2192A>T	c.(2191-2193)gAg>gTg	p.E731V	ABCB7_ENST00000373394.3_Missense_Mutation_p.E730V|ABCB7_ENST00000339447.4_Missense_Mutation_p.E690V	NM_001271696.1|NM_004299.3	NP_001258625.1|NP_004290.2	O75027	ABCB7_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 7	730					cellular iron ion homeostasis	integral to membrane|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|heme transporter activity			breast(1)|endometrium(5)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)	20						TCTTTCCTCCTCTTTGGATAT	0.378000													11	49					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124399735	124399735	+	Silent	SNP	C	C	T			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr10:124399735C>T	ENST00000368909.3	+	52	6841	c.6735C>T	c.(6733-6735)gtC>gtT	p.V2245V	DMBT1_ENST00000330163.4_Silent_p.V1617V|DMBT1_ENST00000368955.3_Silent_p.V2235V|DMBT1_ENST00000359586.6_Silent_p.V965V|DMBT1_ENST00000368956.2_Silent_p.V1617V|DMBT1_ENST00000344338.3_Silent_p.V2235V|DMBT1_ENST00000338354.3_Silent_p.V2245V	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	2245	ZP.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CCATCCAGGTCGAGGAAGTCC	0.468000													53	62					0	0	1	0	0
OR2T8	343172	broad.mit.edu	37	1	248084460	248084460	+	Silent	SNP	T	T	C			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr1:248084460T>C	ENST00000319968.4	+	1	141	c.141T>C	c.(139-141)atT>atC	p.I47I		NM_001005522.1	NP_001005522.1	A6NH00	OR2T8_HUMAN	olfactory receptor, family 2, subfamily T, member 8	47					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(20)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	34	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0211)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			TTCTCCTGATTCACTGGGACC	0.527000													15	41					0	0	1	0	0
CTPS2	56474	broad.mit.edu	37	X	16627768	16627768	+	Missense_Mutation	SNP	A	A	T			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chrX:16627768A>T	ENST00000443824.1	-	17	2330	c.1587T>A	c.(1585-1587)ttT>ttA	p.F529L	CTPS2_ENST00000380241.3_Missense_Mutation_p.F529L|CTPS2_ENST00000359276.4_Missense_Mutation_p.F529L	NM_001144002.1	NP_001137474.1	Q9NRF8	PYRG2_HUMAN	CTP synthase 2	529	Glutamine amidotransferase type-1.				glutamine metabolic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine nucleotide biosynthetic process	cytosol	ATP binding|CTP synthase activity			breast(1)|endometrium(3)|large_intestine(4)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	Hepatocellular(33;0.0997)					GCCTAGAAGAAAACTCAGGAT	0.453000													14	33					0	0	1	0	0
CNTN5	53942	broad.mit.edu	37	11	99827718	99827718	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr11:99827718C>T	ENST00000524871.1	+	8	1144	c.854C>T	c.(853-855)aCg>aTg	p.T285M	CNTN5_ENST00000279463.3_Missense_Mutation_p.T285M|CNTN5_ENST00000528682.1_Missense_Mutation_p.T285M|CNTN5_ENST00000527185.1_Missense_Mutation_p.T285M|CNTN5_ENST00000418526.2_Missense_Mutation_p.T211M	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	285					cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		AGTCCTCCAACGCCACTCACT	0.393000													10	15					0	0	1	0	0
SCRN3	79634	broad.mit.edu	37	2	175264775	175264775	+	Silent	SNP	A	A	G			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr2:175264775A>G	ENST00000272732.6	+	3	367	c.285A>G	c.(283-285)gtA>gtG	p.V95V	SCRN3_ENST00000409673.3_Silent_p.V88V	NM_001193528.1|NM_024583.4	NP_001180457.1|NP_078859.2	Q0VDG4	SCRN3_HUMAN	secernin 3	95					proteolysis		dipeptidase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|urinary_tract(3)	13			OV - Ovarian serous cystadenocarcinoma(117;0.229)			ATGAAGCTGTATGGGGAAGAG	0.428000													45	54					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179482162	179482162	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr2:179482162G>C	ENST00000589042.1	-	254	47874	c.47650C>G	c.(47650-47652)Ctg>Gtg	p.L15884V	TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.L6944V|TTN_ENST00000460472.2_Missense_Mutation_p.L6819V|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.L13316V|TTN_ENST00000342175.6_Missense_Mutation_p.L7011V|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.L14243V|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000589830.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	14243	Fibronectin type-III 15.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCATCTTTCAGAGGAGGTTCC	0.418000													4	8					0	0	1	0	0
SLC12A8	84561	broad.mit.edu	37	3	124839569	124839569	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr3:124839569C>T	ENST00000430155.2	-	1	129	c.101G>A	c.(100-102)gGa>gAa	p.G34E	SLC12A8_ENST00000393469.4_Intron|SLC12A8_ENST00000469902.1_Intron|SLC12A8_ENST00000314584.7_Intron|SLC12A8_ENST00000423114.2_Intron|SLC12A8_ENST00000465475.1_Intron			A0AV02	S12A8_HUMAN	solute carrier family 12, member 8	0					potassium ion transport	integral to membrane	symporter activity			endometrium(2)|kidney(2)|lung(12)	16						TGAGCAGCCTCCTCCACGCAT	0.667000													8	6					0	0	1	0	0
ZNF746	155061	broad.mit.edu	37	7	149172440	149172440	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr7:149172440C>A	ENST00000340622.3	-	7	1250	c.970G>T	c.(970-972)Gcc>Tcc	p.A324S	ZNF746_ENST00000458143.2_Missense_Mutation_p.A325S			Q6NUN9	ZN746_HUMAN	zinc finger protein 746	324					negative regulation of transcription, DNA-dependent|neuron death|regulation of cell death|transcription, DNA-dependent	cytoplasm|nucleus	transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			CCTTCCTGGGCAGGACTAGGG	0.652000													16	13					3.41278e-10	3.6403e-10	1	1	0
KCNN3	3782	broad.mit.edu	37	1	154698405	154698405	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr1:154698405T>C	ENST00000271915.4	-	5	2003	c.1688A>G	c.(1687-1689)cAg>cGg	p.Q563R	KCNN3_ENST00000361147.4_Missense_Mutation_p.Q258R|KCNN3_ENST00000358505.2_Missense_Mutation_p.Q250R	NM_001204087.1|NM_002249.5	NP_001191016.1|NP_002240.3	Q9UGI6	KCNN3_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3							integral to membrane	calmodulin binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(11)|prostate(4)|skin(1)	28	all_lung(78;2.29e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.108)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00819)			CTTGGTGAGCTGAGTGTCCAT	0.557000													7	7					0	0	1	0	0
KLHL4	56062	broad.mit.edu	37	X	86772965	86772965	+	Silent	SNP	T	T	C			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chrX:86772965T>C	ENST00000373119.4	+	1	214	c.69T>C	c.(67-69)agT>agC	p.S23S	KLHL4_ENST00000373114.4_Silent_p.S23S	NM_019117.4	NP_061990.2	Q9C0H6	KLHL4_HUMAN	kelch-like family member 4	23						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(29)|ovary(2)|prostate(1)|skin(1)	67						GGTGGTTTAGTCATCCTTTTC	0.498000													50	55					0	0	1	0	0
FBXW7	55294	broad.mit.edu	37	4	153249385	153249385	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr4:153249385G>A	ENST00000281708.4	-	9	2622	c.1393C>T	c.(1393-1395)Cgt>Tgt	p.R465C	FBXW7_ENST00000603841.1_Missense_Mutation_p.R465C|FBXW7_ENST00000393956.3_Missense_Mutation_p.R289C|FBXW7_ENST00000603548.1_Missense_Mutation_p.R465C|FBXW7_ENST00000296555.5_Missense_Mutation_p.R347C|FBXW7_ENST00000263981.5_Missense_Mutation_p.R385C	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	465			R -> C (in a acute lymphoblastic leukemia cell line).|R -> H (in a colorectal cancer sample; somatic mutation).		interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.R465C(71)|p.R226C(11)|p.R385C(11)|p.R347C(3)|p.R465Y(2)|p.?(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TGCATACAACGCACAGTGGAA	0.413000			"""Mis, N, D, F"""		"""colorectal, endometrial, T-ALL"""								33	61					0	0	1	0	0
CELF2	10659	broad.mit.edu	37	10	11363177	11363177	+	Silent	SNP	G	G	A			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr10:11363177G>A	ENST00000379261.4	+	11	1175	c.1083G>A	c.(1081-1083)gcG>gcA	p.A361A	CELF2_ENST00000427450.1_Silent_p.A343A|CELF2_ENST00000315874.4_Silent_p.A343A|CELF2_ENST00000450189.1_Silent_p.A374A|CELF2_ENST00000542579.1_Silent_p.A374A|CELF2_ENST00000537122.1_Silent_p.A256A|CELF2_ENST00000354897.3_Silent_p.A355A|CELF2_ENST00000354440.2_Silent_p.A343A|CELF2_ENST00000608830.1_Silent_p.A341A|CELF2_ENST00000416382.2_Silent_p.A361A|CELF2_ENST00000609692.1_Silent_p.A341A|CELF2_ENST00000417956.2_Silent_p.A341A|CELF2_ENST00000399850.3_Silent_p.A343A	NM_001025077.2	NP_001020248.1	O95319	CELF2_HUMAN	CUGBP, Elav-like family member 2	361	Ala-rich.|Necessary for RNA-binding, TNNT2 exon 5 and NMDA R1 exon 21 inclusion.				mRNA processing|regulation of heart contraction	cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(2)|lung(5)|prostate(1)|skin(1)	16						CAGGTATGGCGGCTCTGAATG	0.488000													22	26					0	0	1	0	0
NALCN	259232	broad.mit.edu	37	13	102047641	102047641	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr13:102047641C>T	ENST00000251127.6	-	3	265	c.184G>A	c.(184-186)Gag>Aag	p.E62K	NALCN_ENST00000376200.5_Missense_Mutation_p.E62K|NALCN_ENST00000470333.1_5'UTR|NALCN_ENST00000376196.3_Missense_Mutation_p.E62K	NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	62						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					GGATAGTGCTCGAAGGTCATT	0.448000													24	29					0	0	1	0	0
PMS2CL	441194	broad.mit.edu	37	7	6777026	6777026	+	RNA	SNP	G	G	A			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr7:6777026G>A	ENST00000486256.1	+	0	1153					NR_002217.1																						CGGACAGAGCGGAGGTGGAGA	0.587000													31	27					0	0	1	0	0
CSNK1G1	53944	broad.mit.edu	37	15	64495385	64495385	+	Missense_Mutation	SNP	T	T	A			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr15:64495385T>A	ENST00000303052.7	-	10	1426	c.1003A>T	c.(1003-1005)Act>Tct	p.T335S	CTD-2116N17.1_ENST00000606793.1_Missense_Mutation_p.T317S|CSNK1G1_ENST00000303032.6_Missense_Mutation_p.T335S|CSNK1G1_ENST00000607537.1_Missense_Mutation_p.T335S	NM_022048.3	NP_071331.2	Q9HCP0	KC1G1_HUMAN	casein kinase 1, gamma 1	335					Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|urinary_tract(1)	13						CCTACTGGAGTAGGCTAGAAA	0.423000													15	20					0	0	1	0	0
ARHGEF12	23365	broad.mit.edu	37	11	120319046	120319046	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr11:120319046C>G	ENST00000397843.2	+	20	1892	c.1726C>G	c.(1726-1728)Ccc>Gcc	p.P576A	ARHGEF12_ENST00000356641.3_Missense_Mutation_p.P557A|ARHGEF12_ENST00000532993.1_Missense_Mutation_p.P473A	NM_015313.2	NP_056128.1	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	576					apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(5)|endometrium(6)|kidney(5)|large_intestine(13)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(2)	61		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		TGGATTTCTTCCCAAAATCAA	0.383000			T	MLL	AML								20	24					0	0	1	0	0
ATAD5	79915	broad.mit.edu	37	17	29187504	29187504	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr17:29187504G>C	ENST00000321990.4	+	10	3388	c.3010G>C	c.(3010-3012)Gaa>Caa	p.E1004Q	CTD-2349P21.11_ENST00000580873.1_RNA	NM_024857.3	NP_079133.3	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	1004					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(18)|lung(13)|ovary(3)|pancreas(1)	51		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				CGTAGAAGCAGAAAATTCTAA	0.353000													24	33					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8201101	8201101	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr19:8201101C>T	ENST00000600128.1	-	12	1852	c.1438G>A	c.(1438-1440)Gcc>Acc	p.A480T	FBN3_ENST00000270509.2_Missense_Mutation_p.A480T|FBN3_ENST00000601739.1_Missense_Mutation_p.A480T			Q75N90	FBN3_HUMAN	fibrillin 3	480	EGF-like 4; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						GTGGGCGTGGCCTGGAAGCCC	0.652000													27	26					0	0	1	0	0
SRC	6714	broad.mit.edu	37	20	36014528	36014528	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr20:36014528A>G	ENST00000373578.2	+	5	650	c.301A>G	c.(301-303)Aca>Gca	p.T101A	SRC_ENST00000373567.2_Missense_Mutation_p.T101A|SRC_ENST00000360723.4_Missense_Mutation_p.T101A|SRC_ENST00000373558.2_Missense_Mutation_p.T101A|SRC_ENST00000445403.1_Missense_Mutation_p.T101A|SRC_ENST00000358208.4_Missense_Mutation_p.T101A	NM_198291.1	NP_938033.1	P12931	SRC_HUMAN	v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog	101	SH3.				axon guidance|bone resorption|cell junction assembly|cellular membrane organization|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular protein kinase cascade|leukocyte migration|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of integrin activation|Ras protein signal transduction|regulation of bone resorption|regulation of vascular permeability|response to interleukin-1|signal complex assembly|T cell costimulation	caveola|cytosol|mitochondrial inner membrane	ATP binding|heme binding|integrin binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|SH3/SH2 adaptor activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(16)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	30		Myeloproliferative disorder(115;0.00878)			Dasatinib(DB01254)	TAGGACGGAGACAGACCTGTC	0.582000													50	117					0	0	1	0	0
SLC7A3	84889	broad.mit.edu	37	X	70146021	70146021	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chrX:70146021G>T	ENST00000374299.3	-	11	1772	c.1628C>A	c.(1627-1629)gCt>gAt	p.A543D	SLC7A3_ENST00000298085.4_Missense_Mutation_p.A543D			Q8WY07	CTR3_HUMAN	solute carrier family 7 (cationic amino acid transporter, y+ system), member 3	543					cellular nitrogen compound metabolic process	integral to membrane|plasma membrane				breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|liver(1)|lung(9)|ovary(1)|urinary_tract(1)	31	Renal(35;0.156)				L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	GAGAGGCAAAGCAGGCACCTG	0.458000													12	11					6.40141e-05	6.60791e-05	1	1	0
NCK1	4690	broad.mit.edu	37	3	136646888	136646888	+	Silent	SNP	C	C	G			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr3:136646888C>G	ENST00000481752.1	+	2	209	c.45C>G	c.(43-45)gcC>gcG	p.A15A	NCK1_ENST00000288986.2_Silent_p.A15A			P16333	NCK1_HUMAN	NCK adaptor protein 1	15	SH3 1.				axon guidance|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of translation|signal complex assembly|T cell activation|T cell receptor signaling pathway	cytosol|endoplasmic reticulum|nucleus	cytoskeletal adaptor activity|receptor binding|receptor signaling complex scaffold activity			cervix(1)|endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	13						ATTATGTGGCCCAACAAGAAC	0.398000													22	33					0	0	1	0	0
PRDM16	63976	broad.mit.edu	37	1	3328297	3328297	+	Silent	SNP	C	C	T			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr1:3328297C>T	ENST00000378398.3	+	10	1621	c.1539C>T	c.(1537-1539)ccC>ccT	p.P513P	PRDM16_ENST00000378391.2_Silent_p.P512P|PRDM16_ENST00000442529.2_Silent_p.P512P|PRDM16_ENST00000514189.1_Silent_p.P513P|PRDM16_ENST00000511072.1_Silent_p.P513P|PRDM16_ENST00000441472.2_Silent_p.P512P|PRDM16_ENST00000270722.5_Silent_p.P512P|PRDM16_ENST00000512462.1_3'UTR			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	512	Pro-rich.				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		CACTCACCCCCGGCTTCCCGG	0.677000			T	EVI1	"""MDS, AML"""								39	44					0	0	1	0	0
C1QTNF3-AMACR	100534612	broad.mit.edu	37	5	34005931	34005931	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr5:34005931C>T	ENST00000382079.3	-	7	837	c.763G>A	c.(763-765)Gag>Aag	p.E255K	AMACR_ENST00000426255.2_Silent_p.L107L|AMACR_ENST00000512079.1_Silent_p.L107L|AMACR_ENST00000382085.3_Silent_p.L107L|AMACR_ENST00000382072.2_Silent_p.L107L|AMACR_ENST00000335606.6_Silent_p.L107L|AMACR_ENST00000382068.3_Silent_p.L107L|AMACR_ENST00000441713.2_Silent_p.L107L|AMACR_ENST00000514195.1_5'UTR|AMACR_ENST00000502637.1_Silent_p.L107L						0																	CAAATCCACTCAGCCTGGCAT	0.443000													19	31					0	0	1	0	0
KCNT2	343450	broad.mit.edu	37	1	196300310	196300310	+	Silent	SNP	T	T	C			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr1:196300310T>C	ENST00000367433.5	-	18	2180	c.2079A>G	c.(2077-2079)ccA>ccG	p.P693P	KCNT2_ENST00000451324.2_Silent_p.P304P|KCNT2_ENST00000498426.1_5'UTR|KCNT2_ENST00000609185.1_Silent_p.P643P|KCNT2_ENST00000294725.9_Silent_p.P693P|KCNT2_ENST00000367431.4_Silent_p.P643P	NM_198503.2	NP_940905.2	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	693						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						AGCAGCAAAATGGTACTTTTT	0.284000													64	70					0	0	1	0	0
VPS35	55737	broad.mit.edu	37	16	46716046	46716046	+	Silent	SNP	A	A	G			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr16:46716046A>G	ENST00000299138.7	-	3	202	c.144T>C	c.(142-144)aaT>aaC	p.N48N		NM_018206.4	NP_060676.2	Q96QK1	VPS35_HUMAN	vacuolar protein sorting 35 homolog (S. cerevisiae)	48					protein transport|retrograde transport, endosome to Golgi	cytosol|endosome|membrane	protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(11)|pancreas(1)|prostate(1)|urinary_tract(1)	23		all_cancers(37;7.65e-05)|all_epithelial(9;0.000154)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				CACCAAGCATATTAGAAGCAT	0.323000													18	26					0	0	1	0	0
RPS6KA2	6196	broad.mit.edu	37	6	166836852	166836852	+	Silent	SNP	C	C	T			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr6:166836852C>T	ENST00000510118.1	-	19	2050	c.1710G>A	c.(1708-1710)ggG>ggA	p.G570G	RPS6KA2_ENST00000405189.3_Silent_p.G456G|RPS6KA2_ENST00000265678.4_Silent_p.G545G|RPS6KA2_ENST00000509742.1_5'UTR|RPS6KA2_ENST00000503859.1_Silent_p.G553G|RPS6KA2_ENST00000481261.2_Silent_p.G456G			Q15349	KS6A2_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 2	545	Protein kinase 2.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(15)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	45		Breast(66;2.04e-05)|Ovarian(120;0.0652)|Prostate(117;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.76e-18)|GBM - Glioblastoma multiforme(31;9.94e-06)|BRCA - Breast invasive adenocarcinoma(81;1.36e-05)		ATTCTGGGCTCCCCGACTCAT	0.592000													16	22					0	0	1	0	0
SPATA5L1	79029	broad.mit.edu	37	15	45695688	45695688	+	Missense_Mutation	SNP	T	T	A			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr15:45695688T>A	ENST00000305560.6	+	1	1160	c.1061T>A	c.(1060-1062)cTg>cAg	p.L354Q	SPATA5L1_ENST00000559860.1_Missense_Mutation_p.L354Q	NM_024063.2	NP_076968.2	Q9BVQ7	SPA5L_HUMAN	spermatogenesis associated 5-like 1	354						cytoplasm	ATP binding|nucleoside-triphosphatase activity			kidney(2)|large_intestine(3)|lung(1)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	14		Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;7.31e-17)|GBM - Glioblastoma multiforme(94;6.28e-07)		GACCCAGCGCTGCGTAGGCCC	0.672000													16	46					0	0	1	0	0
KRTAP10-10	353333	broad.mit.edu	37	21	46057649	46057649	+	Silent	SNP	C	C	T	rs68027322		TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr21:46057649C>T	ENST00000380095.1	+	1	377	c.315C>T	c.(313-315)tgC>tgT	p.C105C	TSPEAR_ENST00000323084.4_Intron	NM_181688.1	NP_859016.1	P60014	KR10A_HUMAN	keratin associated protein 10-10	105	15 X 5 AA repeats of C-C-X(3).					keratin filament				NS(1)|endometrium(2)|kidney(1)|lung(6)|prostate(1)|skin(2)	13						ccgtctgctgcgtgcccgtct	0.627000													29	48					0	0	1	0	0
MAGEB6	158809	broad.mit.edu	37	X	26212040	26212040	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chrX:26212040C>T	ENST00000379034.1	+	2	226	c.77C>T	c.(76-78)aCg>aTg	p.T26M		NM_173523.2	NP_775794.2	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	26										breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(18)|ovary(3)|prostate(2)	33						CAGGGTCTCACGGGTCCCCAG	0.577000													23	28					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24884859	24884859	+	Missense_Mutation	SNP	T	T	G			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr14:24884859T>G	ENST00000382554.3	+	9	4222	c.3904T>G	c.(3904-3906)Tct>Gct	p.S1302A		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	1302					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						GCCGCCTTTCTCTGACCTGTC	0.617000													48	66					0	0	1	0	0
HOXB4	3214	broad.mit.edu	37	17	46654347	46654347	+	Missense_Mutation	SNP	A	A	C			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr17:46654347A>C	ENST00000332503.5	-	2	2284	c.493T>G	c.(493-495)Tct>Gct	p.S165A	HOXB3_ENST00000498678.1_Intron|HOXB3_ENST00000460160.1_Intron|HOXB-AS3_ENST00000465846.2_RNA|HOXB3_ENST00000489475.1_Intron|HOXB3_ENST00000552000.2_Intron|HOXB3_ENST00000465120.3_Intron|HOXB3_ENST00000472863.1_Intron|HOXB3_ENST00000476342.1_Intron	NM_024015.4	NP_076920.1	P17483	HXB4_HUMAN	homeobox B4	165						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(2)|ovary(1)|urinary_tract(2)	9						GCGGTCCGAGAGCGCTTGGGC	0.592000													45	38					0	0	1	0	0
GPC6	10082	broad.mit.edu	37	13	94482693	94482693	+	Silent	SNP	C	C	T			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr13:94482693C>T	ENST00000377047.4	+	3	1221	c.606C>T	c.(604-606)gaC>gaT	p.D202D	GPC6-AS2_ENST00000445540.1_RNA	NM_005708.3	NP_005699.1	Q9Y625	GPC6_HUMAN	glypican 6	202						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	38	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;5.48e-07)|all_epithelial(2;5.69e-08)|all_lung(2;2.19e-05)|Lung NSC(4;6.09e-05)|Breast(118;0.0395)|Renal(2;0.0568)|Hepatocellular(115;0.217)				CATTTGGAGACGTGCCCCGGA	0.507000													30	32					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51875151	51875151	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr6:51875151C>A	ENST00000371117.3	-	35	5982	c.5707G>T	c.(5707-5709)Gtc>Ttc	p.V1903F	PKHD1_ENST00000340994.4_Missense_Mutation_p.V1903F	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	1903					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity	p.V1903I(1)		NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					GTAATCTTGACGGTAATTGGC	0.393000													29	21					3.80469e-20	4.23479e-20	1	1	0
ATP8B2	57198	broad.mit.edu	37	1	154318785	154318785	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr1:154318785G>C	ENST00000368489.3	+	25	2956	c.2956G>C	c.(2956-2958)Gag>Cag	p.E986Q		NM_020452.3	NP_065185.1	P98198	AT8B2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 2	972					ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity		IL6R/ATP8B2(2)	breast(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CAACAAGCGGGAGTTCTTCAT	0.567000													6	61					0	0	1	0	0
OTOP2	92736	broad.mit.edu	37	17	72926502	72926502	+	Silent	SNP	C	C	T			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr17:72926502C>T	ENST00000331427.4	+	6	864	c.772C>T	c.(772-774)Ctg>Ttg	p.L258L	OTOP2_ENST00000580223.1_Silent_p.L258L	NM_178160.2	NP_835454.1	Q7RTS6	OTOP2_HUMAN	otopetrin 2	258						integral to membrane				breast(4)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(13)|ovary(3)|prostate(4)|skin(1)|urinary_tract(2)	39	all_lung(278;0.172)|Lung NSC(278;0.207)					CTCCACCATGCTGTATGTCAT	0.572000													63	158					0	0	1	0	0
ESYT3	83850	broad.mit.edu	37	3	138179501	138179501	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr3:138179501G>A	ENST00000389567.4	+	7	973	c.787G>A	c.(787-789)Gga>Aga	p.G263R	ESYT3_ENST00000289135.4_Missense_Mutation_p.G263R	NM_031913.3	NP_114119.2	A0FGR9	ESYT3_HUMAN	extended synaptotagmin-like protein 3	263						integral to membrane|plasma membrane				breast(1)|endometrium(5)|large_intestine(7)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	25						GGATGCGCCGGGAATCAAGTA	0.597000													50	58					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15688901	15688901	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr10:15688901C>T	ENST00000378076.3	-	12	1504	c.1151G>A	c.(1150-1152)gGg>gAg	p.G384E		NM_003638.1	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8	384					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity	p.G384L(1)		NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						ACCGAATCTCCCAAACGTCTC	0.483000													12	23					0	0	1	0	0
UNC93A	54346	broad.mit.edu	37	6	167719501	167719501	+	Silent	SNP	C	C	T			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr6:167719501C>T	ENST00000230256.3	+	6	1114	c.939C>T	c.(937-939)gtC>gtT	p.V313V	UNC93A_ENST00000366829.2_Silent_p.V271V	NM_018974.3	NP_061847.2	Q86WB7	UN93A_HUMAN	unc-93 homolog A (C. elegans)	313						integral to membrane|plasma membrane				breast(2)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	40		Breast(66;7.62e-05)|Ovarian(120;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		ATGGAAAGGTCTCGCAGTACA	0.572000													46	47					0	0	1	0	0
TUBBP5	643224	broad.mit.edu	37	9	141070695	141070695	+	RNA	SNP	G	G	A			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr9:141070695G>A	ENST00000503395.1	+	0	1470																		p.R105H(1)									GCCAAGGGACGCTACACCGAA	0.592000													2	1					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126371488	126371488	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr4:126371488C>T	ENST00000394329.3	+	9	9330	c.9317C>T	c.(9316-9318)tCc>tTc	p.S3106F	FAT4_ENST00000335110.5_Missense_Mutation_p.S1404F	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3106	Cadherin 30.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						AGCATTGGGTCCATTGTCAGA	0.428000													20	17					0	0	1	0	0
FBXL7	23194	broad.mit.edu	37	5	15936877	15936877	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr5:15936877G>A	ENST00000504595.1	+	4	1539	c.1058G>A	c.(1057-1059)cGg>cAg	p.R353Q	FBXL7_ENST00000510662.1_Missense_Mutation_p.R306Q|FBXL7_ENST00000329673.7_Missense_Mutation_p.R341Q	NM_001278317.1|NM_012304.3	NP_001265246.1|NP_036436.1	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	353					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity	p.R353Q(1)		cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(13)|lung(33)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	60						TCCCGCCTGCGGTACCTGAGC	0.662000													3	13					0	0	1	0	0
TET3	200424	broad.mit.edu	37	2	74326457	74326457	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr2:74326457G>A	ENST00000409262.3	+	8	2917	c.2917G>A	c.(2917-2919)Gag>Aag	p.E973K		NM_144993.1	NP_659430.1	O43151	TET3_HUMAN	tet methylcytosine dioxygenase 3	973							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						TCCCGAGGATGAGCAGCTGCA	0.592000													8	9					0	0	1	0	0
ELF3	1999	broad.mit.edu	37	1	201982393	201982394	+	Frame_Shift_Ins	INS	-	-	G			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr1:201982393_201982394insG	ENST00000359651.3	+	6	3964_3965	c.772_773insG	c.(772-774)tggfs	p.W258fs	ELF3_ENST00000367284.5_Frame_Shift_Ins_p.W258fs|RP11-510N19.5_ENST00000504773.1_RNA|ELF3_ENST00000367283.3_Frame_Shift_Ins_p.W258fs			P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription factor, epithelial-specific )	258					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	20						CAAAGAGTACTGGGACTGTCTC	0.649													29	21	---	---	---	---					
RASSF5	83593	broad.mit.edu	37	1	206680949	206680949	+	Frame_Shift_Del	DEL	C	C	-			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr1:206680949delC	ENST00000355294.4	+	1	71	c.14delC	c.(13-15)tccfs	p.S5fs	RASSF5_ENST00000367117.3_Frame_Shift_Del_p.S5fs	NM_182663.2	NP_872604.1	Q8WWW0	RASF5_HUMAN	Ras association (RalGDS/AF-6) domain family member 5	5					apoptosis|intracellular signal transduction	cytoplasm|microtubule	metal ion binding|protein binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)	8	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)			GCCATGGCGTCCCCGGCCATC	0.736													2	4	---	---	---	---					
RRP36	88745	broad.mit.edu	37	6	42989414	42989419	+	In_Frame_Del	DEL	GCCGGG	GCCGGG	-	rs60664426		TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr6:42989414_42989419delGCCGGG	ENST00000244496.5	+	1	32_37	c.22_27delGCCGGG	c.(22-27)gccgggdel	p.AG14del		NM_033112.2	NP_149103.1	Q96EU6	RRP36_HUMAN	ribosomal RNA processing 36 homolog (S. cerevisiae)	14					ribosomal small subunit biogenesis|rRNA processing	nucleolus		p.A8_G9delAG(2)		NS(1)|breast(1)|central_nervous_system(1)|large_intestine(5)|lung(1)|ovary(1)|prostate(1)	11						TAACTAccgcgccggggccggggccg	0.777													2	4	---	---	---	---					
SGK223	157285	broad.mit.edu	37	8	8234868	8234869	+	In_Frame_Ins	INS	-	-	GCCGCT	rs59372311	by1000genomes	TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr8:8234868_8234869insGCCGCT	ENST00000520004.1	-	3	1314_1315	c.1050_1051insAGCGGC	c.(1048-1053)ggcgcc>ggcAGCGGCgcc	p.349_350insGS	SGK223_ENST00000330777.4_In_Frame_Ins_p.349_350insGS			Q86YV5	SG223_HUMAN		349							ATP binding|non-membrane spanning protein tyrosine kinase activity	p.G350_A351insSG(1)|p.G350_S351insSG(1)									GGGCTACTGGCGCCGCTGCCGC	0.653													8	6	---	---	---	---					
TRAV9-2	28677	broad.mit.edu	37	14	22409533	22409539	+	RNA	DEL	CTCTCTC	CTCTCTC	-	rs57759840		TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr14:22409533_22409539delCTCTCTC	ENST00000390441.2	+	0	102																											ctctctctctctctctctTTTTTTTTT	0.415													6	3	---	---	---	---					
TMED10	10972	broad.mit.edu	37	14	75601711	75601712	+	Splice_Site	DEL	TA	TA	-			TCGA-XF-AAN1-01A-31D-A42E-08	TCGA-XF-AAN1-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e5eb8078-cd89-449f-98c0-34da693d3e95	6dbe6f80-7c36-454f-b310-ba07c345c733	g.chr14:75601711_75601712delTA	ENST00000303575.4	-	5	590		c.e5-2		RP11-950C14.7_ENST00000556236.1_RNA|TMED10_ENST00000557670.1_Splice_Site	NM_006827.5	NP_006818.3	P49755	TMEDA_HUMAN	transmembrane emp24-like trafficking protein 10 (yeast)						protein transport|regulated secretory pathway|vesicle targeting, to, from or within Golgi	cis-Golgi network|ER-Golgi intermediate compartment|Golgi membrane|integral to membrane|melanosome|microsome|zymogen granule membrane	protein binding			endometrium(1)|large_intestine(5)|lung(3)	9				BRCA - Breast invasive adenocarcinoma(234;0.0126)		TTGTTGACTCTAAAAAAAAACA	0.426													19	22	---	---	---	---