Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CYC1	1537	broad.mit.edu	37	8	145152184	145152184	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr8:145152184G>A	ENST00000318911.4	+	7	996	c.923G>A	c.(922-924)cGg>cAg	p.R308Q		NM_001916.3	NP_001907	P08574	CY1_HUMAN	cytochrome c-1	308					respiratory electron transport chain|transport	cell junction|integral to membrane|mitochondrial inner membrane|respiratory chain	electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity|heme binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(2)	15	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;8.71e-40)|all cancers(56;3e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			ACCATAAAGCGGCACAAGTGG	0.587000													13	20					0	0	1	0	0
CCT8	10694	broad.mit.edu	37	21	30440001	30440001	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr21:30440001A>G	ENST00000286788.4	-	4	463	c.257T>C	c.(256-258)aTt>aCt	p.I86T	CCT8_ENST00000542732.1_Missense_Mutation_p.I67T|CCT8_ENST00000540844.1_Missense_Mutation_p.I13T|CCT8_ENST00000470450.1_5'UTR	NM_006585.2	NP_006576.2	P50990	TCPQ_HUMAN	chaperonin containing TCP1, subunit 8 (theta)	86					'de novo' posttranslational protein folding	aggresome|cytosol|intermediate filament cytoskeleton|microtubule organizing center	ATP binding|ATPase activity, coupled|unfolded protein binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|liver(1)|lung(1)|prostate(3)	14						AGCCATTACAATCATTTTTGC	0.368000													4	69					0	0	1	0	0
PPFIBP1	8496	broad.mit.edu	37	12	27825375	27825375	+	Silent	SNP	C	C	T			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr12:27825375C>T	ENST00000318304.8	+	15	1612	c.1329C>T	c.(1327-1329)atC>atT	p.I443I	PPFIBP1_ENST00000537927.1_Silent_p.I290I|PPFIBP1_ENST00000542629.1_Silent_p.I412I|PPFIBP1_ENST00000228425.6_Silent_p.I426I	NM_001198916.1|NM_177444.2	NP_001185845.1|NP_803193	Q86W92	LIPB1_HUMAN	PTPRF interacting protein, binding protein 1 (liprin beta 1)	443					cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(13)|prostate(2)|skin(1)	32	Lung SC(9;0.0873)					GAAACATAATCCTTGGTGCCA	0.313000													8	17					0	0	1	0	0
PLEKHG4	25894	broad.mit.edu	37	16	67316524	67316524	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr16:67316524C>T	ENST00000360461.5	+	9	3907	c.1372C>T	c.(1372-1374)Cgg>Tgg	p.R458W	PLEKHG4_ENST00000450733.1_Missense_Mutation_p.R377W|PLEKHG4_ENST00000427155.2_Missense_Mutation_p.R458W|PLEKHG4_ENST00000379344.3_Missense_Mutation_p.R458W	NM_001129727.1|NM_015432.3	NP_001123199.1|NP_056247.1	Q58EX7	PKHG4_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4	458					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)|Kidney(780;0.119)		ACTGGAGGCCCGGGAAAGCGG	0.582000													24	26					0	0	1	0	0
TGM4	7047	broad.mit.edu	37	3	44943123	44943123	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr3:44943123G>T	ENST00000296125.4	+	7	833	c.765G>T	c.(763-765)caG>caT	p.Q255H		NM_003241.3	NP_003232.2	P49221	TGM4_HUMAN	transglutaminase 4	255					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(9)|lung(21)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	38				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	TCCTGCAGCAGTACTACAACA	0.582000													3	31					1	1	1	1	0
FN1	2335	broad.mit.edu	37	2	216274346	216274346	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr2:216274346C>T	ENST00000354785.4	-	15	2608	c.2239G>A	c.(2239-2241)Gtg>Atg	p.V747M	FN1_ENST00000357009.2_Missense_Mutation_p.V747M|FN1_ENST00000443816.1_Missense_Mutation_p.V747M|FN1_ENST00000336916.4_Missense_Mutation_p.V747M|FN1_ENST00000421182.1_Missense_Mutation_p.V747M|FN1_ENST00000432072.2_Missense_Mutation_p.V747M|FN1_ENST00000357867.4_Missense_Mutation_p.V747M|FN1_ENST00000359671.1_Missense_Mutation_p.V747M|FN1_ENST00000345488.5_Missense_Mutation_p.V747M|FN1_ENST00000346544.3_Missense_Mutation_p.V747M|FN1_ENST00000356005.4_Missense_Mutation_p.V747M|FN1_ENST00000446046.1_Missense_Mutation_p.V747M|FN1_ENST00000323926.6_Missense_Mutation_p.V747M			P02751	FINC_HUMAN	fibronectin 1	747	Fibronectin type-III 2.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding		FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AATCCCGACACGGTGTCGGAA	0.537000													13	26					0	0	1	0	0
C16orf98	100652740	broad.mit.edu	37	16	31214015	31214015	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr16:31214015T>C	ENST00000561916.2	+	2	337	c.241T>C	c.(241-243)Tcc>Ccc	p.S81P	PYCARD_ENST00000350605.4_5'UTR|PYCARD_ENST00000247470.9_5'UTR					chromosome 16 open reading frame 98																		GCCCCATGGCTCCAGGATCCC	0.711000													21	32					0	0	1	0	0
RPS6KA2	6196	broad.mit.edu	37	6	166831732	166831732	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr6:166831732G>A	ENST00000510118.1	-	21	2334	c.1994C>T	c.(1993-1995)tCg>tTg	p.S665L	RPS6KA2_ENST00000405189.3_Missense_Mutation_p.S551L|RPS6KA2_ENST00000265678.4_Missense_Mutation_p.S640L|RPS6KA2_ENST00000503859.1_Missense_Mutation_p.S648L|RPS6KA2_ENST00000509742.1_5'UTR|RPS6KA2_ENST00000481261.2_Missense_Mutation_p.S551L			Q15349	KS6A2_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 2	640	Protein kinase 2.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(15)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	45		Breast(66;2.04e-05)|Ovarian(120;0.0652)|Prostate(117;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.76e-18)|GBM - Glioblastoma multiforme(31;9.94e-06)|BRCA - Breast invasive adenocarcinoma(81;1.36e-05)		GTCAGATATCGAGTCCCAGTT	0.488000													41	71					0	0	1	0	0
ITGAV	3685	broad.mit.edu	37	2	187528498	187528498	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr2:187528498C>T	ENST00000261023.3	+	19	2135	c.1861C>T	c.(1861-1863)Cac>Tac	p.H621Y	ITGAV_ENST00000374907.3_Missense_Mutation_p.H585Y|AC017101.10_ENST00000453665.1_RNA|ITGAV_ENST00000433736.2_Missense_Mutation_p.H575Y	NM_002210.3	NP_002201	P06756	ITAV_HUMAN	integrin, alpha V	621					angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		TTTCTAGGCTCACATTCTACT	0.328000													13	29					0	0	1	0	0
INPP5E	56623	broad.mit.edu	37	9	139324229	139324229	+	Silent	SNP	T	T	C			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr9:139324229T>C	ENST00000371712.3	-	10	2235	c.1833A>G	c.(1831-1833)agA>agG	p.R611R		NM_019892.4	NP_063945.2	Q9NRR6	INP5E_HUMAN	inositol polyphosphate-5-phosphatase, 72 kDa	611						cilium axoneme|cytoskeleton|Golgi cisterna membrane	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity			NS(1)|endometrium(1)|lung(4)|skin(3)	9		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;8.36e-06)|Epithelial(140;1.4e-05)		AGTACAGTTCTCTATCAAATT	0.552000													33	40					0	0	1	0	0
NPIPB11	728888	broad.mit.edu	37	16	29415043	29415043	+	Silent	SNP	G	G	A			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr16:29415043G>A	ENST00000524087.1	-	2	155	c.81C>T	c.(79-81)caC>caT	p.H27H	SNX29P2_ENST00000398878.3_lincRNA					nuclear pore complex interacting protein family, member B11									p.H27H(24)									CTGACTTTACGTGCTGCTGCA	0.577000													3	13					0	0	1	0	0
PRDM5	11107	broad.mit.edu	37	4	121738036	121738036	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr4:121738036G>A	ENST00000264808.3	-	6	934	c.694C>T	c.(694-696)Cga>Tga	p.R232*	PRDM5_ENST00000515109.1_Intron|PRDM5_ENST00000428209.2_Intron	NM_018699.2	NP_061169.2	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	232					histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(17)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						TGAAAACTTCGCGAAGACTCC	0.378000													68	130					0	0	1	0	0
RP11-144L1.4	0	broad.mit.edu	37	1	158450698	158450698	+	RNA	SNP	C	C	T			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr1:158450698C>T	ENST00000419738.1	-	0	1379				RP11-144L1.4_ENST00000426251.1_RNA																							TTTTAGATTTCTTAATAAATA	0.284000													6	12					0	0	1	0	0
ITGAE	3682	broad.mit.edu	37	17	3680919	3680919	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr17:3680919C>A	ENST00000263087.4	-	2	168	c.70G>T	c.(70-72)Gcc>Tcc	p.A24S		NM_002208.4	NP_002199.3	P38570	ITAE_HUMAN	integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)	24					cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		CAGGGCCGGGCCACATCCACA	0.592000													10	38					0.000442599	0.000456877	1	1	0
MRGPRX2	117194	broad.mit.edu	37	11	19077768	19077768	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr11:19077768C>T	ENST00000329773.2	-	2	269	c.182G>A	c.(181-183)aGg>aAg	p.R61K		NM_054030.2	NP_473371.1	Q96LB1	MRGX2_HUMAN	MAS-related GPR, member X2	61					sensory perception of pain|sleep	plasma membrane	G-protein coupled receptor activity|neuropeptide binding			NS(1)|large_intestine(2)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(2)|urinary_tract(1)	15						GAAGGCGTTCCTGCGCATGCG	0.562000													52	21					0	0	1	0	0
HSD17B7	51478	broad.mit.edu	37	1	162769603	162769603	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr1:162769603G>A	ENST00000367917.3	+	5	586	c.518G>A	c.(517-519)aGt>aAt	p.S173N	HSD17B7_ENST00000485405.1_3'UTR|HSD17B7_ENST00000254521.3_Missense_Mutation_p.S173N			P56937	DHB7_HUMAN	hydroxysteroid (17-beta) dehydrogenase 7	173					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	3-keto sterol reductase activity|estradiol 17-beta-dehydrogenase activity	p.S173N(4)		endometrium(3)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|skin(1)	9	all_hematologic(112;0.115)				NADH(DB00157)	TCATCTCGCAGTGCAAGGAAA	0.458000													3	45					0	0	1	0	0
GIT2	9815	broad.mit.edu	37	12	110385083	110385083	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr12:110385083C>G	ENST00000360185.4	-	14	1633	c.1469G>C	c.(1468-1470)aGa>aCa	p.R490T	GIT2_ENST00000553118.1_Intron|GIT2_ENST00000361006.5_Missense_Mutation_p.R540T|GIT2_ENST00000457474.2_Missense_Mutation_p.R492T|GIT2_ENST00000355312.3_Missense_Mutation_p.R540T|GIT2_ENST00000356259.4_Intron|GIT2_ENST00000338373.5_Intron|GIT2_ENST00000551209.1_Missense_Mutation_p.R489T|GIT2_ENST00000343646.5_Missense_Mutation_p.R460T|GIT2_ENST00000354574.4_Missense_Mutation_p.R492T|TCHP_ENST00000550780.1_Intron	NM_014776.3	NP_055591.2	Q14161	GIT2_HUMAN	G protein-coupled receptor kinase interacting ArfGAP 2	540					regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	nucleoplasm	ARF GTPase activator activity|protein binding|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(8)|skin(4)	27						GGGCTGGAGTCTCATCCTGCT	0.577000													18	30					0	0	1	0	0
PCDHB4	56131	broad.mit.edu	37	5	140502959	140502959	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr5:140502959G>A	ENST00000194152.1	+	1	1379	c.1379G>A	c.(1378-1380)cGc>cAc	p.R460H		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		460	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTGTTCGTCCGCGAGAACAAC	0.627000													48	62					0	0	1	0	0
NAA15	80155	broad.mit.edu	37	4	140291413	140291413	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr4:140291413G>A	ENST00000296543.5	+	15	2125	c.1802G>A	c.(1801-1803)aGa>aAa	p.R601K	NAA15_ENST00000398947.1_Missense_Mutation_p.R601K	NM_057175.3	NP_476516.1	Q9BXJ9	NAA15_HUMAN	N(alpha)-acetyltransferase 15, NatA auxiliary subunit	601					angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			NS(1)|endometrium(3)|large_intestine(7)|liver(2)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	29						AAACAAAGAAGAGCTCAAAAG	0.333000													11	23					0	0	1	0	0
CD163L1	283316	broad.mit.edu	37	12	7531611	7531611	+	Silent	SNP	C	C	T			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr12:7531611C>T	ENST00000313599.3	-	9	2391	c.2334G>A	c.(2332-2334)gcG>gcA	p.A778A	CD163L1_ENST00000396630.1_Silent_p.A778A|CD163L1_ENST00000416109.2_Silent_p.A788A|CD163L1_ENST00000544331.1_5'UTR			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	778	SRCR 7.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						TTAAATGACACGCAGTCTGTT	0.368000													30	55					0	0	1	0	0
PDGFRA	5156	broad.mit.edu	37	4	55124986	55124986	+	Splice_Site	SNP	T	T	C			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr4:55124986T>C	ENST00000257290.5	+	2	380		c.e2+2		PDGFRA_ENST00000508170.1_Splice_Site|FIP1L1_ENST00000507166.1_Intron	NM_006206.4	NP_006197.1	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor, alpha polypeptide						cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			NS(1)|autonomic_ganglia(1)|bone(1)|breast(4)|central_nervous_system(17)|cervix(1)|endometrium(4)|eye(1)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(22)|kidney(6)|large_intestine(26)|liver(4)|lung(48)|ovary(4)|prostate(6)|skin(11)|small_intestine(49)|soft_tissue(727)|stomach(32)|urinary_tract(1)	967	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	TTCTCACAGGTACGGAGCCCA	0.463000			"""Mis, O, T"""	FIP1L1	"""GIST, idiopathic hypereosinophilic syndrome, paediatric GBM"""				Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Intestinal Neurofibromatosis	TSP Lung(21;0.16)			3	94					0	0	1	0	0
ZNF613	79898	broad.mit.edu	37	19	52447758	52447758	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr19:52447758G>A	ENST00000293471.6	+	6	1301	c.622G>A	c.(622-624)Gag>Aag	p.E208K	ZNF613_ENST00000391794.4_Missense_Mutation_p.E172K	NM_001031721.3	NP_001026891.2	Q6PF04	ZN613_HUMAN	zinc finger protein 613	208					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	19		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.0183)		TGTATGCACTGAGTGTGGGAA	0.428000													80	148					0	0	1	0	0
CREB5	9586	broad.mit.edu	37	7	28857695	28857695	+	Missense_Mutation	SNP	T	T	G			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr7:28857695T>G	ENST00000357727.2	+	10	1652	c.1262T>G	c.(1261-1263)gTg>gGg	p.V421G	CREB5_ENST00000396300.2_Missense_Mutation_p.V414G|CREB5_ENST00000396299.2_Missense_Mutation_p.V388G|CREB5_ENST00000396298.2_Missense_Mutation_p.V282G|CREB5_ENST00000409603.1_Missense_Mutation_p.V388G	NM_182898.2	NP_878901.2	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	421	Leucine-zipper.				positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(13)|prostate(1)|skin(3)	32						TAGAATGAAGTGTCTATGTTG	0.393000													5	96					0	0	1	0	0
CHIA	27159	broad.mit.edu	37	1	111860424	111860424	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr1:111860424C>T	ENST00000369740.1	+	7	705	c.602C>T	c.(601-603)tCa>tTa	p.S201L	RP5-1125M8.2_ENST00000426321.1_RNA|CHIA_ENST00000451398.2_Missense_Mutation_p.S40L|CHIA_ENST00000483391.1_Missense_Mutation_p.S40L|CHIA_ENST00000430615.1_Missense_Mutation_p.S93L|CHIA_ENST00000353665.6_Missense_Mutation_p.S40L|CHIA_ENST00000343320.6_Missense_Mutation_p.S201L	NM_001258001.1|NM_201653.3	NP_001244930.1|NP_970615.2	Q9BZP6	CHIA_HUMAN	chitinase, acidic	201					apoptosis|cell wall chitin metabolic process|chitin catabolic process|digestion|immune response|positive regulation of chemokine secretion|production of molecular mediator involved in inflammatory response|response to acid|response to fungus	cytoplasm|extracellular space	cation binding|chitin binding|chitinase activity|kinase binding|lysozyme activity|sugar binding			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|skin(1)	23		all_cancers(81;3.23e-05)|all_epithelial(167;1.2e-05)|all_lung(203;0.000154)|Lung NSC(277;0.000304)		Colorectal(144;0.0115)|Lung(183;0.0292)|COAD - Colon adenocarcinoma(174;0.0314)|all cancers(265;0.0477)|Epithelial(280;0.0918)|LUSC - Lung squamous cell carcinoma(189;0.154)		CCCCAACTGTCACAGTGAGTG	0.527000													19	33					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98608704	98608704	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr7:98608704G>C	ENST00000359863.4	+	70	11135	c.10926G>C	c.(10924-10926)caG>caC	p.Q3642H	TRRAP_ENST00000446306.3_Missense_Mutation_p.Q3631H|TRRAP_ENST00000355540.3_Missense_Mutation_p.Q3613H	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	3642	PI3K/PI4K.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			AGGAGGTTCAGAGTAACATGG	0.522000													14	21					0	0	1	0	0
SMARCAD1	56916	broad.mit.edu	37	4	95197489	95197489	+	Splice_Site	SNP	G	G	C			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr4:95197489G>C	ENST00000354268.4	+	15	1881		c.e15-1		SMARCAD1_ENST00000457823.2_Splice_Site|SMARCAD1_ENST00000509418.1_Splice_Site			Q9H4L7	SMRCD_HUMAN	SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1						chromatin modification|nucleotide metabolic process|positive regulation of transcription, DNA-dependent|protein homooligomerization|regulation of DNA recombination	nuclear matrix	ATP binding|DNA binding|helicase activity			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|liver(2)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	44				OV - Ovarian serous cystadenocarcinoma(123;4.33e-08)		TTTGGTGACAGATATAACTGT	0.343000													25	41					0	0	1	0	0
SEC11C	90701	broad.mit.edu	37	18	56819839	56819839	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr18:56819839G>C	ENST00000587834.1	+	3	741	c.269G>C	c.(268-270)aGa>aCa	p.R90T	SEC11C_ENST00000588875.1_Missense_Mutation_p.R90T	NM_033280.2	NP_150596.1	Q9BY50	SC11C_HUMAN	SEC11 homolog C (S. cerevisiae)	90					energy reserve metabolic process|regulation of insulin secretion|signal peptide processing	endoplasmic reticulum membrane|integral to membrane|microsome	serine-type peptidase activity			endometrium(1)|large_intestine(4)|liver(2)|lung(2)	9		Colorectal(73;0.175)				GACCCAATCAGAGCTGGTGAA	0.423000													61	120					0	0	1	0	0
CTC1	80169	broad.mit.edu	37	17	8136307	8136307	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr17:8136307A>G	ENST00000315684.8	-	11	1869	c.1862T>C	c.(1861-1863)cTg>cCg	p.L621P		NM_025099.5	NP_079375.3	Q2NKJ3	CTC1_HUMAN	CTS telomere maintenance complex component 1	621					positive regulation of DNA replication|telomere maintenance	Stn1-Ten1 complex	protein binding|single-stranded DNA binding			NS(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(8)|ovary(1)|skin(4)	29						CCGAAGTTGCAGACAACCTTT	0.483000													48	55					0	0	1	0	0
STK33	65975	broad.mit.edu	37	11	8496318	8496318	+	Silent	SNP	T	T	A			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr11:8496318T>A	ENST00000447869.1	-	1	1053	c.135A>T	c.(133-135)acA>acT	p.T45T	STK33_ENST00000534493.1_Silent_p.T4T|STK33_ENST00000358872.3_Intron|STK33_ENST00000315204.1_Silent_p.T45T|STK33_ENST00000396672.1_Silent_p.T45T|STK33_ENST00000396673.1_Silent_p.T45T			Q9BYT3	STK33_HUMAN	serine/threonine kinase 33	45						Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|skin(3)	23				Epithelial(150;2.13e-06)|BRCA - Breast invasive adenocarcinoma(625;0.239)		CAATGCTTGATGTCTGTGACA	0.378000													45	76					0	0	1	0	0
KLHL31	401265	broad.mit.edu	37	6	53519742	53519742	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr6:53519742C>A	ENST00000370905.3	-	2	469	c.329G>T	c.(328-330)aGg>aTg	p.R110M	KLHL31_ENST00000407079.1_Missense_Mutation_p.R110M	NM_001003760.4	NP_001003760.2	Q9H511	KLH31_HUMAN	kelch-like family member 31	110	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent					autonomic_ganglia(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|prostate(3)	20	Lung NSC(77;0.0158)					GAGATCCACCCTCTGAATTGA	0.413000													40	92					6.1244e-12	6.4256e-12	1	1	0
MAATS1	89876	broad.mit.edu	37	3	119449127	119449127	+	Silent	SNP	G	G	A			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr3:119449127G>A	ENST00000273390.5	+	8	998	c.921G>A	c.(919-921)caG>caA	p.Q307Q		NM_033364.3	NP_203528			MYCBP-associated, testis expressed 1																		AAGAGAATCAGAATGAAGTGA	0.418000													29	108					0	0	1	0	0
RGL4	266747	broad.mit.edu	37	22	24036559	24036559	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr22:24036559C>G	ENST00000290691.5	+	5	2108	c.938C>G	c.(937-939)tCc>tGc	p.S313C	RGL4_ENST00000401461.1_Missense_Mutation_p.S177C|KB-1572G7.2_ENST00000421064.1_RNA	NM_153615.1	NP_705843.1	Q8IZJ4	RGDSR_HUMAN	ral guanine nucleotide dissociation stimulator-like 4	313	Ras-GEF.				small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle	guanyl-nucleotide exchange factor activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(3)	15						AACAACTTCTCCTCGGTGCAC	0.582000													19	30					0	0	1	0	0
HRAS	3265	broad.mit.edu	37	11	533874	533874	+	Missense_Mutation	SNP	T	T	A	rs121913233		TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr11:533874T>A	ENST00000417302.1	-	3	369	c.182A>T	c.(181-183)cAg>cTg	p.Q61L	HRAS_ENST00000397596.2_Missense_Mutation_p.Q61L|HRAS_ENST00000311189.7_Missense_Mutation_p.Q61L|HRAS_ENST00000397594.1_Missense_Mutation_p.Q61L|HRAS_ENST00000468682.2_5'UTR|HRAS_ENST00000451590.1_Missense_Mutation_p.Q61L	NM_176795.3	NP_789765.1	P01112	RASH_HUMAN	Harvey rat sarcoma viral oncogene homolog	61			Q -> K (in follicular thyroid carcinoma samples; somatic mutation; increases transformation of cultured cell lines; dbSNP:rs28933406).|Q -> L (in melanoma; strongly reduced GTP hydrolysis in the presence of RAF1; increases transformation of cultured cell lines).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.Q61R(136)|p.Q61L(117)|p.Q61P(3)		adrenal_gland(1)|bone(3)|breast(7)|cervix(23)|endometrium(4)|haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|oesophagus(2)|penis(2)|pituitary(10)|prostate(31)|salivary_gland(24)|skin(184)|soft_tissue(38)|stomach(14)|testis(5)|thymus(1)|thyroid(173)|upper_aerodigestive_tract(122)|urinary_tract(225)	901		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	GTACTCCTCCTGGCCGGCGGT	0.597000	Q61L(KNS62_LUNG)|Q61L(KYSE30_OESOPHAGUS)|Q61L(NCIH1915_LUNG)	6	Mis		"""infrequent sarcomas, rare other types"""	"""rhadomyosarcoma, ganglioneuroblastoma, bladder"""			Costello syndrome	HNSCC(11;0.0054)			59	16					0	0	1	0	0
CDR2L	30850	broad.mit.edu	37	17	73000112	73000112	+	Silent	SNP	C	C	T			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr17:73000112C>T	ENST00000337231.5	+	5	1753	c.1341C>T	c.(1339-1341)atC>atT	p.I447I		NM_014603.2	NP_055418.2	Q86X02	CDR2L_HUMAN	cerebellar degeneration-related protein 2-like	447												all_lung(278;0.226)					TCTCCAGGATCCAGAAGACCA	0.607000													8	15					0	0	1	0	0
RLF	6018	broad.mit.edu	37	1	40704531	40704531	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr1:40704531C>G	ENST00000372771.4	+	8	4184	c.4157C>G	c.(4156-4158)tCt>tGt	p.S1386C		NM_012421.3	NP_036553.2	Q13129	RLF_HUMAN	rearranged L-myc fusion	1386					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(18)|lung(18)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(4)|urinary_tract(2)	68	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			TGTAGTGATTCTCATAACCTA	0.393000													41	45					0	0	1	0	0
FASTKD1	79675	broad.mit.edu	37	2	170387987	170387987	+	Silent	SNP	G	G	A			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr2:170387987G>A	ENST00000453153.2	-	13	2548	c.2202C>T	c.(2200-2202)atC>atT	p.I734I	FASTKD1_ENST00000495505.1_5'UTR|FASTKD1_ENST00000453929.2_Silent_p.I691I	NM_024622.3	NP_078898.3	Q53R41	FAKD1_HUMAN	FAST kinase domains 1	734					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(5)|large_intestine(10)|lung(9)|ovary(4)|prostate(3)	37						TTTTATCCAAGATACACTCAA	0.313000													9	26					0	0	1	0	0
EPHA7	2045	broad.mit.edu	37	6	94066764	94066764	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr6:94066764G>A	ENST00000369303.4	-	5	1179	c.995C>T	c.(994-996)cCa>cTa	p.P332L		NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	332	Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		TGGTGCAGATGGAGGCCCTTG	0.398000													11	29					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152738145	152738145	+	Silent	SNP	G	G	A			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr6:152738145G>A	ENST00000367255.5	-	41	6028	c.5427C>T	c.(5425-5427)caC>caT	p.H1809H	SYNE1_ENST00000423061.1_Silent_p.H1816H|SYNE1_ENST00000341594.5_Silent_p.H1846H|SYNE1_ENST00000448038.1_Silent_p.H1816H|SYNE1_ENST00000265368.4_Silent_p.H1809H	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1809					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTTCTGCTGCGTGGTCCTGGA	0.483000										HNSCC(10;0.0054)			17	46					0	0	1	0	0
CUX2	23316	broad.mit.edu	37	12	111652022	111652022	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr12:111652022G>A	ENST00000261726.6	+	2	236	c.82G>A	c.(82-84)Gct>Act	p.A28T		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	28						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						TAATTCCGTCGCTTCTGAGCT	0.358000													17	39					0	0	1	0	0
CDH11	1009	broad.mit.edu	37	16	65016142	65016142	+	Silent	SNP	G	G	A			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr16:65016142G>A	ENST00000394156.3	-	8	1515	c.1062C>T	c.(1060-1062)atC>atT	p.I354I	CDH11_ENST00000268603.4_Silent_p.I354I|CDH11_ENST00000566827.1_Silent_p.I228I			P55287	CAD11_HUMAN	cadherin 11, type 2, OB-cadherin (osteoblast)	354	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(19)|lung(40)|ovary(3)|prostate(3)|skin(2)|urinary_tract(2)	88		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		ACTTCGGGTCGATGTGCACGT	0.468000			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			28	48					0	0	1	0	0
NCOR1P1	149934	broad.mit.edu	37	20	26084183	26084183	+	RNA	SNP	C	C	T			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr20:26084183C>T	ENST00000478176.1	-	0	274					NR_003678.1																						TCGATCTACACGATCCATACA	0.363000													11	38					0	0	1	0	0
TFB2M	64216	broad.mit.edu	37	1	246711851	246711851	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr1:246711851C>T	ENST00000366514.4	-	6	1039	c.854G>A	c.(853-855)cGt>cAt	p.R285H	TFB2M_ENST00000544618.1_3'UTR	NM_022366.2	NP_071761.1	Q9H5Q4	TFB2M_HUMAN	transcription factor B2, mitochondrial	285					positive regulation of transcription, DNA-dependent|transcription initiation from mitochondrial promoter	mitochondrial nucleoid	protein binding|rRNA (adenine-N6,N6-)-dimethyltransferase activity|transcription cofactor activity			breast(1)|endometrium(1)|kidney(12)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	28	all_cancers(71;4.25e-05)|all_epithelial(71;4.92e-06)|Ovarian(71;0.0254)|all_lung(81;0.0272)|Breast(184;0.0318)|Lung NSC(105;0.0376)		OV - Ovarian serous cystadenocarcinoma(106;0.00358)			TCTTACCCTACGCTTTGGGTT	0.348000													15	30					0	0	1	0	0
ARHGEF28	64283	broad.mit.edu	37	5	73136383	73136383	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr5:73136383C>G	ENST00000545377.1	+	11	1401	c.1225C>G	c.(1225-1227)Ctg>Gtg	p.L409V	ARHGEF28_ENST00000513841.1_3'UTR|ARHGEF28_ENST00000513042.2_Missense_Mutation_p.L409V|ARHGEF28_ENST00000437974.1_Missense_Mutation_p.L409V|ARHGEF28_ENST00000426542.2_Missense_Mutation_p.L409V|ARHGEF28_ENST00000287898.5_Missense_Mutation_p.L409V|ARHGEF28_ENST00000296794.6_Missense_Mutation_p.L409V|ARHGEF28_ENST00000296799.4_Missense_Mutation_p.L96V	NM_001080479.2	NP_001073948.2			Rho guanine nucleotide exchange factor (GEF) 28																		AGGTTGCACTCTGTGGCCTCA	0.468000													19	24					0	0	1	0	0
PDXDC2P	283970	broad.mit.edu	37	16	70065826	70065826	+	RNA	SNP	T	T	C	rs3169319	by1000genomes	TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr16:70065826T>C	ENST00000531894.1	-	0	796					NR_003610.1													p.M209V(4)									GATCCAAACATAGTGTTACAG	0.453000													4	85					0	0	1	0	0
UBA6	55236	broad.mit.edu	37	4	68514802	68514802	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr4:68514802G>T	ENST00000322244.5	-	14	1291	c.1232C>A	c.(1231-1233)tCt>tAt	p.S411Y		NM_018227.5	NP_060697.4	A0AVT1	UBA6_HUMAN	ubiquitin-like modifier activating enzyme 6						protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding			central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(6)|liver(1)|lung(23)|skin(2)|upper_aerodigestive_tract(2)	44						GCACAAAGGAGAAAATTTTCC	0.378000													43	70					1.8453e-21	2.00168e-21	1	1	0
GJA4	2701	broad.mit.edu	37	1	35260203	35260203	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr1:35260203T>C	ENST00000342280.4	+	2	477	c.389T>C	c.(388-390)gTa>gCa	p.V130A		NM_002060.2	NP_002051.2	P35212	CXA4_HUMAN	gap junction protein, alpha 4, 37kDa	130			V -> I (in dbSNP:rs41266431).		cell-cell junction assembly	integral to plasma membrane				NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(3)|prostate(4)|stomach(1)	14		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)				CTGGCGGCCGTAGAGCGTCAG	0.652000													3	14					0	0	1	0	0
MED13	9969	broad.mit.edu	37	17	60040276	60040276	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr17:60040276G>C	ENST00000397786.2	-	21	4977	c.4901C>G	c.(4900-4902)aCg>aGg	p.T1634R		NM_005121.2	NP_005112.2	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	1634					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(4)|central_nervous_system(1)|endometrium(10)|kidney(24)|large_intestine(15)|liver(1)|lung(20)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						AGGTGGATACGTGACTGCATG	0.388000													8	126					0	0	1	0	0
KLHL1	57626	broad.mit.edu	37	13	70371010	70371010	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr13:70371010C>A	ENST00000377844.4	-	7	2258	c.1499G>T	c.(1498-1500)gGt>gTt	p.G500V	KLHL1_ENST00000545028.1_Missense_Mutation_p.G307V	NM_020866.2	NP_065917.1	Q9NR64	KLHL1_HUMAN	kelch-like family member 1	500					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(56)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	84		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		AACAGCCACACCAAACTGCAG	0.398000													37	74					2.87052e-16	3.06189e-16	1	1	0
HRAS	3265	broad.mit.edu	37	11	533309	533309	+	Frame_Shift_Del	DEL	G	G	-			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr11:533309delG	ENST00000417302.1	-	5	687	c.500delC	c.(499-501)ccgfs	p.P167fs	HRAS_ENST00000311189.7_Intron|HRAS_ENST00000451590.1_Intron|HRAS_ENST00000397596.2_Intron|HRAS_ENST00000397594.1_Frame_Shift_Del_p.P167fs	NM_176795.3	NP_789765.1	P01112	RASH_HUMAN	Harvey rat sarcoma viral oncogene homolog	0	Hypervariable region.				activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding			adrenal_gland(1)|bone(3)|breast(7)|cervix(23)|endometrium(4)|haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|oesophagus(2)|penis(2)|pituitary(10)|prostate(31)|salivary_gland(24)|skin(184)|soft_tissue(38)|stomach(14)|testis(5)|thymus(1)|thyroid(173)|upper_aerodigestive_tract(122)|urinary_tract(225)	901		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	CATGGGTCCCGGGGGGTCCCA	0.721		6	Mis		"""infrequent sarcomas, rare other types"""	"""rhadomyosarcoma, ganglioneuroblastoma, bladder"""			Costello syndrome	HNSCC(11;0.0054)			11	3	---	---	---	---					
WDR81	124997	broad.mit.edu	37	17	1631341	1631343	+	In_Frame_Del	DEL	GAG	GAG	-	rs66598941		TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr17:1631341_1631343delGAG	ENST00000409644.1	+	1	3088_3090	c.3088_3090delGAG	c.(3088-3090)gagdel	p.E1033del	WDR81_ENST00000419248.1_Intron|WDR81_ENST00000446363.1_Intron|WDR81_ENST00000437219.2_Intron|RP11-961A15.1_ENST00000576540.1_RNA|WDR81_ENST00000309182.5_5'UTR	NM_001163809.1	NP_001157281.1	B3KXU1	B3KXU1_HUMAN	WD repeat domain 81	305										cervix(1)|endometrium(1)|kidney(3)|lung(6)|ovary(2)|prostate(2)|skin(1)	16				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		AGGGGCTGCTGAGGAGGAGGAGA	0.695													5	3	---	---	---	---					
ZNF844	284391	broad.mit.edu	37	19	12187546	12187547	+	Frame_Shift_Ins	INS	-	-	A	rs73923376	by1000genomes	TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr19:12187546_12187547insA	ENST00000439326.3	+	4	1786_1787	c.1611_1612insA	c.(1612-1614)aaafs	p.K538fs	ZNF844_ENST00000441304.2_3'UTR	NM_001136501.1	NP_001129973.1	Q08AG5	ZN844_HUMAN	zinc finger protein 844	538					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(1)|prostate(1)	10						TAAACAATGTGAAAAAACCTTT	0.391													9	21	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11085863	11085864	+	RNA	INS	-	-	C			TCGA-XF-A9T4-01A-11D-A391-08	TCGA-XF-A9T4-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bb661102-6e30-4c9c-9506-6c65a79a8f32	179a8520-e156-48ad-91a1-2079c2de6d4f	g.chr21:11085863_11085864insC	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		catcaccaccaccaccatcacc	0.579													4	3	---	---	---	---