Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ARL4A	10124	broad.mit.edu	37	7	12728098	12728098	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr7:12728098C>G	ENST00000396663.1	+	2	701	c.219C>G	c.(217-219)ttC>ttG	p.F73L	ARL4A_ENST00000396662.1_Missense_Mutation_p.F73L|ARL4A_ENST00000396664.2_Missense_Mutation_p.F73L|ARL4A_ENST00000356797.3_Missense_Mutation_p.F73L|ARL4A_ENST00000404894.1_Missense_Mutation_p.F73L	NM_001037164.2|NM_001195396.1|NM_005738.4|NM_212460.3	NP_001032241.1|NP_001182325.1|NP_005729.1|NP_997625.1	P40617	ARL4A_HUMAN	ADP-ribosylation factor-like 4A	73					small GTPase mediated signal transduction	cytoplasm|nucleolus|plasma membrane	GTP binding|protein binding			NS(2)|lung(3)|ovary(1)	6				UCEC - Uterine corpus endometrioid carcinoma (126;0.176)		CTTTTCACTTCTGGGATGTAG	0.388000													5	50					0	0	1	0	0
IFNA21	3452	broad.mit.edu	37	9	21166192	21166192	+	Silent	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr9:21166192G>A	ENST00000380225.1	-	1	467	c.420C>T	c.(418-420)atC>atT	p.I140I		NM_002175.2	NP_002166.2	P01568	IFN21_HUMAN	interferon, alpha 21	140					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|skin(3)	14				GBM - Glioblastoma multiforme(5;1.93e-187)|Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		TCACAGCCAGGATGGAGTCCA	0.468000													89	254					0	0	1	0	0
RAD54L2	23132	broad.mit.edu	37	3	51667733	51667733	+	Silent	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr3:51667733C>T	ENST00000409535.2	+	7	1091	c.966C>T	c.(964-966)ctC>ctT	p.L322L	RAD54L2_ENST00000296477.3_Silent_p.L16L	NM_015106.2	NP_055921.2	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2 (S. cerevisiae)		Helicase ATP-binding.					nucleus	ATP binding|DNA binding|helicase activity			NS(2)|breast(1)|cervix(2)|endometrium(4)|large_intestine(5)|liver(2)|lung(9)|ovary(4)|skin(2)	31				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)		TCGACGTCCTCTTCCGCCACA	0.512000													8	79					0	0	1	0	0
CDC14B	8555	broad.mit.edu	37	9	99285702	99285702	+	Splice_Site	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr9:99285702C>T	ENST00000375241.1	-	11	1537	c.1086G>A	c.(1084-1086)atG>atA	p.M362I	CDC14B_ENST00000375240.3_Splice_Site_p.M362I|CDC14B_ENST00000265659.2_Splice_Site_p.M362I|CDC14B_ENST00000375236.1_Splice_Site_p.M362I|CDC14B_ENST00000463569.1_Splice_Site_p.M362I|CDC14B_ENST00000375242.3_Splice_Site_p.M325I	NM_003671.3|NM_033331.2	NP_003662.1|NP_201588.1	O60729	CC14B_HUMAN	cell division cycle 14B	362	B.				activation of anaphase-promoting complex activity|DNA repair|G2/M transition DNA damage checkpoint	nucleolus|nucleoplasm	protein binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)	15		Acute lymphoblastic leukemia(62;0.0559)				TGGTTTGCTTCCTAGAGCATT	0.408000													4	78					0	0	1	0	0
ZSWIM8	23053	broad.mit.edu	37	10	75559895	75559895	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr10:75559895G>C	ENST00000604729.1	+	22	5089	c.4792G>C	c.(4792-4794)Gag>Cag	p.E1598Q	ZSWIM8_ENST00000605216.1_Missense_Mutation_p.E1593Q|ZSWIM8-AS1_ENST00000456638.2_RNA|ZSWIM8_ENST00000603114.1_Missense_Mutation_p.E1560Q|ZSWIM8_ENST00000398706.2_Missense_Mutation_p.E1598Q|ZSWIM8_ENST00000604524.1_Missense_Mutation_p.E1411Q|RP11-574K11.31_ENST00000603027.1_Intron					zinc finger, SWIM-type containing 8																		CTACCACACAGAGCCAGGGCT	0.602000													4	29					0	0	1	0	0
FOXS1	2307	broad.mit.edu	37	20	30433048	30433048	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr20:30433048C>T	ENST00000375978.3	-	1	372	c.298G>A	c.(298-300)Gac>Aac	p.D100N		NM_004118.3	NP_004109.1	O43638	FOXS1_HUMAN	forkhead box S1	100					anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|insulin receptor signaling pathway|lymphangiogenesis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|neural crest cell fate commitment|neuromuscular process controlling balance|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of multicellular organism growth|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|somitogenesis|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			kidney(1)|large_intestine(3)|lung(3)|ovary(1)|urinary_tract(1)	9						TCAAACATGTCGTGGCAGTCA	0.677000													7	30					0	0	1	0	0
HMGXB4	10042	broad.mit.edu	37	22	35660906	35660906	+	Silent	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr22:35660906C>T	ENST00000216106.5	+	5	653	c.525C>T	c.(523-525)ctC>ctT	p.L175L	HMGXB4_ENST00000444518.2_Silent_p.L66L	NM_001003681.2	NP_001003681.1	Q9UGU5	HMGX4_HUMAN	HMG box domain containing 4	175					endosome to lysosome transport|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	NURF complex	DNA binding			breast(1)|endometrium(1)|large_intestine(6)|liver(1)|lung(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						TGAAACCTCTCTATGTGAACA	0.463000													11	88					0	0	1	0	0
PTPRS	5802	broad.mit.edu	37	19	5210810	5210810	+	Silent	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr19:5210810C>T	ENST00000372412.4	-	34	5477	c.5244G>A	c.(5242-5244)caG>caA	p.Q1748Q	PTPRS_ENST00000588552.1_5'UTR|PTPRS_ENST00000262963.6_Silent_p.Q1727Q|PTPRS_ENST00000588012.1_Silent_p.Q1709Q|PTPRS_ENST00000587303.1_Silent_p.Q1747Q|PTPRS_ENST00000592099.1_Silent_p.Q1300Q|PTPRS_ENST00000348075.2_Silent_p.Q1709Q|PTPRS_ENST00000353284.2_Silent_p.Q1300Q|PTPRS_ENST00000357368.4_Silent_p.Q1747Q			Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type, S	1747	Tyrosine-protein phosphatase 2.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(9)|ovary(4)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)	61				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		TGTAGGCCTTCTGCTGCCTGC	0.647000													4	23					0	0	1	0	0
MUC13	56667	broad.mit.edu	37	3	124646580	124646580	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr3:124646580C>T	ENST00000311075.3	-	2	348	c.310G>A	c.(310-312)Gac>Aac	p.D104N		NM_033049.3	NP_149038	Q9H3R2	MUC13_HUMAN	mucin 13, cell surface associated	104	Thr-rich.					extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(5)|prostate(1)|skin(1)|stomach(1)	18						GACTCACTGTCTGCAGCAGTA	0.413000													16	127					0	0	1	0	0
POLE	5426	broad.mit.edu	37	12	133208978	133208978	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr12:133208978C>T	ENST00000320574.5	-	45	6296	c.6253G>A	c.(6253-6255)Gag>Aag	p.E2085K	POLE_ENST00000535270.1_Missense_Mutation_p.E2058K	NM_006231.2	NP_006222.2	Q07864	DPOE1_HUMAN	polymerase (DNA directed), epsilon, catalytic subunit	2085					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			NS(2)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(41)|ovary(3)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	89	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		GGAAACATCTCTGAGAGCTCA	0.512000								DNA polymerases (catalytic subunits)					17	45					0	0	1	0	0
TFAP2A	7020	broad.mit.edu	37	6	10398847	10398847	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr6:10398847G>C	ENST00000379613.3	-	7	1379	c.1123C>G	c.(1123-1125)Cag>Gag	p.Q375E	TFAP2A_ENST00000379604.2_Missense_Mutation_p.Q373E|TFAP2A_ENST00000379608.3_Missense_Mutation_p.Q367E|TFAP2A_ENST00000482890.1_Missense_Mutation_p.Q373E|TFAP2A_ENST00000319516.4_Missense_Mutation_p.Q369E			P05549	AP2A_HUMAN	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	373	H-S-H (helix-span-helix), dimerization.				ectoderm development|positive regulation of bone mineralization|positive regulation of tooth mineralization|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	centrosome|Golgi apparatus|nucleus	chromatin binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			breast(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)	13	Breast(50;0.0427)|Ovarian(93;0.0991)	all_hematologic(90;0.107)				AAGCAGCTCTGGATGCCGGGC	0.637000													21	215					0	0	1	0	0
GZMM	3004	broad.mit.edu	37	19	549733	549733	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr19:549733C>A	ENST00000264553.3	+	5	754	c.716C>A	c.(715-717)gCc>gAc	p.A239D		NM_001258351.1|NM_005317.3	NP_001245280.1|NP_005308	P51124	GRAM_HUMAN	granzyme M (lymphocyte met-ase 1)	239	Peptidase S1.				apoptosis|cytolysis|innate immune response|proteolysis	extracellular region	serine-type endopeptidase activity			endometrium(1)|large_intestine(1)|prostate(1)	3		all_cancers(10;1.94e-35)|all_epithelial(18;5.94e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTCCCGTGGCCACCGCTGTG	0.662000													7	49					2.0095e-06	2.16503e-06	1	1	0
TRIM71	131405	broad.mit.edu	37	3	32932639	32932639	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr3:32932639C>T	ENST00000383763.5	+	4	2006	c.1943C>T	c.(1942-1944)tCc>tTc	p.S648F		NM_001039111.1	NP_001034200.1	Q2Q1W2	LIN41_HUMAN	tripartite motif containing 71, E3 ubiquitin protein ligase						multicellular organismal development	cytoplasm	zinc ion binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						ACCCTGGGCTCCCGGCCTGGG	0.627000													3	19					0	0	1	0	0
SCG2	7857	broad.mit.edu	37	2	224463935	224463935	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr2:224463935G>C	ENST00000305409.2	-	2	298	c.66C>G	c.(64-66)atC>atG	p.I22M		NM_003469.4	NP_003460.2	P13521	SCG2_HUMAN	secretogranin II	22					angiogenesis|endothelial cell migration|eosinophil chemotaxis|induction of positive chemotaxis|inflammatory response|MAPKKK cascade|negative regulation of apoptosis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|protein secretion	extracellular space|stored secretory granule	chemoattractant activity|cytokine activity	p.I22I(1)		NS(1)|breast(1)|endometrium(1)|kidney(6)|large_intestine(10)|liver(1)|lung(16)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	44		Renal(207;0.0112)|Lung NSC(271;0.0185)|all_lung(227;0.0271)		Epithelial(121;8.16e-11)|all cancers(144;4.66e-08)|Lung(261;0.00714)|LUSC - Lung squamous cell carcinoma(224;0.008)		CAGCCCCAGAGATGAGGAAAA	0.423000													9	51					0	0	1	0	0
LAMA4	3910	broad.mit.edu	37	6	112575111	112575111	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr6:112575111G>C	ENST00000368638.4	-	2	512	c.242C>G	c.(241-243)cCg>cGg	p.P81R	RP11-506B6.6_ENST00000590673.1_RNA|LAMA4_ENST00000424408.2_Intron|LAMA4_ENST00000389463.4_Intron|RP11-506B6.6_ENST00000585450.1_RNA|RP11-506B6.6_ENST00000587816.1_RNA|RP11-506B6.6_ENST00000590293.1_RNA|RP11-506B6.6_ENST00000433684.3_RNA|LAMA4_ENST00000522006.1_Intron|LAMA4_ENST00000230538.7_Intron|RP11-506B6.6_ENST00000585611.1_RNA|RP11-506B6.6_ENST00000585504.1_RNA|LAMA4_ENST00000453937.2_Missense_Mutation_p.P81R|RP11-506B6.6_ENST00000590584.1_RNA|RP11-506B6.6_ENST00000590804.1_RNA|LAMA4_ENST00000431543.2_Intron|RP11-506B6.6_ENST00000588837.1_RNA			Q16363	LAMA4_HUMAN	laminin, alpha 4	0					cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			NS(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(42)|ovary(4)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(8)	100		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		CACAGCCCGCGGGGGCGCAGG	0.652000													3	16					0	0	1	0	0
SRCAP	10847	broad.mit.edu	37	16	30721266	30721266	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr16:30721266G>C	ENST00000262518.4	+	8	1336	c.951G>C	c.(949-951)caG>caC	p.Q317H	SRCAP_ENST00000395059.2_Missense_Mutation_p.Q317H|SRCAP_ENST00000344771.4_Missense_Mutation_p.Q317H	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	317	Glu-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			CAGAGGCCCAGAGGCGTGAGA	0.542000													4	29					0	0	1	0	0
ZBTB9	221504	broad.mit.edu	37	6	33423122	33423122	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr6:33423122C>T	ENST00000395064.2	+	2	513	c.245C>T	c.(244-246)gCg>gTg	p.A82V		NM_152735.3	NP_689948.1	Q96C00	ZBTB9_HUMAN	zinc finger and BTB domain containing 9	82	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|skin(1)|upper_aerodigestive_tract(2)	11						CTGGGGGATGCGCCTCGTCTC	0.572000													4	223					0	0	1	0	0
PPT2-EGFL8	100532746	broad.mit.edu	37	6	32130357	32130357	+	Silent	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr6:32130357C>T	ENST00000422437.1	+	8	914	c.723C>T	c.(721-723)ttC>ttT	p.F241F	PPT2_ENST00000361568.2_Silent_p.F247F|PPT2_ENST00000324816.6_Silent_p.F241F|PPT2_ENST00000395523.1_Silent_p.F241F|PPT2_ENST00000375143.2_Silent_p.F241F|PPT2_ENST00000445576.2_Silent_p.F241F|PPT2-EGFL8_ENST00000453656.2_3'UTR|PPT2_ENST00000375137.2_Silent_p.F241F|PPT2_ENST00000437001.2_Silent_p.F118F|PPT2_ENST00000493548.1_3'UTR																							TCTTTGGTTTCTATGATGCAA	0.532000													36	257					0	0	1	0	0
FNTB	2342	broad.mit.edu	37	14	65507601	65507601	+	Silent	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr14:65507601C>T	ENST00000246166.2	+	8	1020	c.786C>T	c.(784-786)ctC>ctT	p.L262L	FNTB_ENST00000447296.2_Silent_p.L296L|FNTB_ENST00000542227.1_Silent_p.L216L|MAX_ENST00000341653.2_Intron|CHURC1-FNTB_ENST00000549987.1_Silent_p.L297L	NM_002028.3	NP_002019.1			farnesyltransferase, CAAX box, beta											breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(2)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	14				all cancers(60;0.00115)|OV - Ovarian serous cystadenocarcinoma(108;0.00412)|BRCA - Breast invasive adenocarcinoma(234;0.011)		TGGTAATCCTCAAGAGGGAAC	0.522000													5	59					0	0	1	0	0
SNHG12	85028	broad.mit.edu	37	1	28907457	28907457	+	RNA	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr1:28907457G>C	ENST00000488745.1	-	0	1013				SNHG12_ENST00000384342.1_RNA|SNHG12_ENST00000483436.1_RNA|SNHG12_ENST00000531126.1_RNA|SNHG12_ENST00000475441.1_RNA																							AAATGTTGCAGATCAGTTACA	0.468000													11	102					0	0	1	0	0
KDM2B	84678	broad.mit.edu	37	12	121878649	121878649	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr12:121878649G>T	ENST00000377069.4	-	20	3779	c.3373C>A	c.(3373-3375)Ctc>Atc	p.L1125I	KDM2B_ENST00000536437.1_Intron|KDM2B_ENST00000377071.4_Missense_Mutation_p.L1194I|KDM2B_ENST00000542973.1_Missense_Mutation_p.L562I	NM_001005366.1	NP_001005366.1	Q8NHM5	KDM2B_HUMAN	lysine (K)-specific demethylase 2B	1194					embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	19						GGGGACAGGAGATCCCGCATC	0.617000													11	31					6.40141e-05	6.79174e-05	1	1	0
ADD1	118	broad.mit.edu	37	4	2910284	2910284	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr4:2910284C>T	ENST00000355842.3	+	13	2421	c.1558C>T	c.(1558-1560)Cag>Tag	p.Q520*	ADD1_ENST00000513328.2_Nonsense_Mutation_p.Q520*|ADD1_ENST00000398125.1_Nonsense_Mutation_p.Q551*|ADD1_ENST00000503455.2_Nonsense_Mutation_p.Q551*|ADD1_ENST00000398129.1_Nonsense_Mutation_p.Q520*|ADD1_ENST00000446856.1_Nonsense_Mutation_p.Q520*|ADD1_ENST00000398123.2_Nonsense_Mutation_p.Q551*|ADD1_ENST00000264758.7_Nonsense_Mutation_p.Q551*			P35611	ADDA_HUMAN	adducin 1 (alpha)	520					actin filament bundle assembly|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|positive regulation of protein binding	cytosol|F-actin capping protein complex|nucleus|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding|transcription factor binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)	22				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GGCTGGCCCTCAGTCCCAGGT	0.567000													9	33					0	0	1	0	0
CKMT2	1160	broad.mit.edu	37	5	80554957	80554957	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr5:80554957G>C	ENST00000424301.2	+	9	1136	c.898G>C	c.(898-900)Gaa>Caa	p.E300Q	CKMT2-AS1_ENST00000511495.1_RNA|CKMT2_ENST00000437669.1_Missense_Mutation_p.E300Q|CKMT2-AS1_ENST00000501927.2_RNA|CKMT2-AS1_ENST00000503483.2_RNA|CKMT2-AS1_ENST00000512287.1_RNA|CKMT2-AS1_ENST00000505295.1_RNA|CKMT2-AS1_ENST00000502041.2_RNA|CKMT2_ENST00000254035.4_Missense_Mutation_p.E300Q|CKMT2-AS1_ENST00000500148.2_RNA	NM_001825.2	NP_001816.2	P17540	KCRS_HUMAN	creatine kinase, mitochondrial 2 (sarcomeric)	300	Phosphagen kinase C-terminal.				creatine metabolic process|muscle contraction	mitochondrial inner membrane	ATP binding|creatine kinase activity			breast(2)|cervix(1)|endometrium(2)|large_intestine(7)|lung(4)|urinary_tract(1)	17		Lung NSC(167;0.00475)|all_lung(232;0.00502)|Ovarian(174;0.0336)		OV - Ovarian serous cystadenocarcinoma(54;2.29e-44)|Epithelial(54;1.05e-38)|all cancers(79;4.15e-34)	Creatine(DB00148)	GTTAATCCAAGAACGAGGCTG	0.468000													22	104					0	0	1	0	0
OR6N1	128372	broad.mit.edu	37	1	158736156	158736156	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr1:158736156G>C	ENST00000335094.2	-	1	336	c.317C>G	c.(316-318)tCc>tGc	p.S106C		NM_001005185.1	NP_001005185.1	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N, member 1	106					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54	all_hematologic(112;0.0378)					CGCTCCAAGGGAGTGAAAGAA	0.502000													4	44					0	0	1	0	0
ZNF224	7767	broad.mit.edu	37	19	44612111	44612111	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr19:44612111G>T	ENST00000336976.6	+	6	2052	c.1798G>T	c.(1798-1800)Gag>Tag	p.E600*	AC084219.4_ENST00000592946.1_RNA	NM_013398.2	NP_037530.2	Q9NZL3	ZN224_HUMAN	zinc finger protein 224	600					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(2)|ovary(2)|prostate(1)|stomach(2)|urinary_tract(1)	19		Prostate(69;0.0435)				CAAATGTGATGAGTGTGGGAA	0.458000													5	89					0.014758	0.0151498	1	1	0
KIAA0556	23247	broad.mit.edu	37	16	27788330	27788330	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr16:27788330C>T	ENST00000261588.4	+	25	4550	c.4531C>T	c.(4531-4533)Cga>Tga	p.R1511*		NM_015202.2	NP_056017.2	O60303	K0556_HUMAN	KIAA0556	1511										breast(4)|endometrium(7)|kidney(8)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	76						AACACCCCATCGAGGGGTGAA	0.453000													32	203					0	0	1	0	0
ZNF423	23090	broad.mit.edu	37	16	49672247	49672247	+	Silent	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr16:49672247G>A	ENST00000561648.1	-	4	869	c.816C>T	c.(814-816)ttC>ttT	p.F272F	ZNF423_ENST00000262383.2_Silent_p.F272F|ZNF423_ENST00000563137.2_Silent_p.F212F|ZNF423_ENST00000562871.1_Silent_p.F212F|ZNF423_ENST00000562520.1_Silent_p.F212F|ZNF423_ENST00000567169.1_Silent_p.F155F|ZNF423_ENST00000535559.1_Silent_p.F155F	NM_001271620.1	NP_001258549.1	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	272					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				CCGTCTGGCTGAAGGTGTCCT	0.597000													4	25					0	0	1	0	0
KCNC4	3749	broad.mit.edu	37	1	110766506	110766506	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr1:110766506C>G	ENST00000369787.3	+	2	1626	c.1599C>G	c.(1597-1599)atC>atG	p.I533M	KCNC4_ENST00000413138.3_Missense_Mutation_p.I533M|KCNC4_ENST00000412512.2_Intron|KCNC4_ENST00000438661.2_Missense_Mutation_p.I533M	NM_004978.4	NP_004969.2	Q03721	KCNC4_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 4	533					synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity	p.I533I(2)		central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(2)|lung(11)|ovary(1)|skin(2)	32		all_cancers(81;9.88e-06)|all_epithelial(167;3.23e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0238)|all cancers(265;0.0693)|Epithelial(280;0.0748)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.135)		AGGGTATGATCGAGAGGAAAC	0.577000													3	18					0	0	1	0	0
BAZ2A	11176	broad.mit.edu	37	12	56996630	56996630	+	Silent	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr12:56996630G>A	ENST00000179765.5	-	20	3400	c.3201C>T	c.(3199-3201)ttC>ttT	p.F1067F	BAZ2A_ENST00000551812.1_Silent_p.F1099F|BAZ2A_ENST00000549884.1_Silent_p.F1097F|BAZ2A_ENST00000379441.3_Silent_p.F1069F			Q9UIF9	BAZ2A_HUMAN	bromodomain adjacent to zinc finger domain, 2A	1099					chromatin silencing at rDNA|DNA methylation|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	DNA binding|histone acetyl-lysine binding|ligand-dependent nuclear receptor binding|RNA binding|zinc ion binding			breast(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(15)|urinary_tract(1)	31						TTTTGCGAAAGAAAAGCTGAC	0.483000													5	9					0	0	1	0	0
CCDC117	150275	broad.mit.edu	37	22	29177081	29177081	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr22:29177081A>G	ENST00000249064.4	+	3	561	c.385A>G	c.(385-387)Att>Gtt	p.I129V	CCDC117_ENST00000448492.2_Missense_Mutation_p.I111V|CCDC117_ENST00000443309.2_5'UTR|CCDC117_ENST00000421503.2_Intron	NM_001284263.1|NM_001284265.1|NM_173510.2	NP_001271192.1|NP_001271194.1|NP_775781.1	Q8IWD4	CC117_HUMAN	coiled-coil domain containing 117	129										breast(1)|kidney(1)|large_intestine(4)|upper_aerodigestive_tract(1)	7						ATTAGATGTTATTTGTGAAGA	0.448000													3	25					0	0	1	0	0
RAP1GAP2	23108	broad.mit.edu	37	17	2867287	2867287	+	Silent	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr17:2867287C>T	ENST00000254695.8	+	7	507	c.417C>T	c.(415-417)ctC>ctT	p.L139L	RAP1GAP2_ENST00000542807.1_Silent_p.L139L|RAP1GAP2_ENST00000366401.4_Silent_p.L124L|CTD-3060P21.1_ENST00000574885.1_RNA|RAP1GAP2_ENST00000540393.2_Silent_p.L120L	NM_015085.4	NP_055900.4	Q684P5	RPGP2_HUMAN	RAP1 GTPase activating protein 2	139					regulation of small GTPase mediated signal transduction	centrosome|cytosol|perinuclear region of cytoplasm	GTPase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	11						AGGACAACCTCAGCCCCAACA	0.612000													12	40					0	0	1	0	0
SRCAP	10847	broad.mit.edu	37	16	30750002	30750002	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr16:30750002C>G	ENST00000262518.4	+	34	9026	c.8641C>G	c.(8641-8643)Ccc>Gcc	p.P2881A	SRCAP_ENST00000395059.2_Missense_Mutation_p.P2819A|SRCAP_ENST00000344771.4_Missense_Mutation_p.P2723A	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	2881	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			GGATGAGGCACCCTCATCCAC	0.582000													4	21					0	0	1	0	0
FLRT1	23769	broad.mit.edu	37	11	63885422	63885422	+	Silent	SNP	G	G	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr11:63885422G>T	ENST00000246841.3	+	2	2726	c.1683G>T	c.(1681-1683)gtG>gtT	p.V561V	MACROD1_ENST00000255681.6_Intron	NM_013280.4	NP_037412.2	Q9NZU1	FLRT1_HUMAN	fibronectin leucine rich transmembrane protein 1	533					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			breast(1)|endometrium(3)|large_intestine(6)|lung(2)|prostate(1)|urinary_tract(1)	14						GCGGGGCAGTGGCTCTGGTCT	0.672000													7	26					8.12818e-05	8.59759e-05	1	1	0
OLAH	55301	broad.mit.edu	37	10	15107623	15107623	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr10:15107623C>T	ENST00000378217.3	+	7	789	c.602C>T	c.(601-603)tCa>tTa	p.S201L	OLAH_ENST00000485251.1_3'UTR|OLAH_ENST00000378228.3_Missense_Mutation_p.S148L	NM_018324.2	NP_060794.1	Q9NV23	SAST_HUMAN	oleoyl-ACP hydrolase	148					fatty acid biosynthetic process		myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity			endometrium(2)|large_intestine(1)|lung(14)|stomach(1)	18						GATGAATTGTCAGAAGAACAA	0.403000													14	48					0	0	1	0	0
PTOV1	53635	broad.mit.edu	37	19	50360994	50360994	+	Silent	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr19:50360994C>G	ENST00000391842.1	+	7	929	c.759C>G	c.(757-759)gtC>gtG	p.V253V	PTOV1_ENST00000221557.9_Silent_p.V221V|AC018766.5_ENST00000593654.1_RNA|PTOV1_ENST00000598325.1_3'UTR|PTOV1_ENST00000601675.1_Silent_p.V253V|PTOV1_ENST00000601638.1_Silent_p.V221V|PTOV1_ENST00000600603.1_Silent_p.V221V|PTOV1_ENST00000599732.1_Silent_p.V253V	NM_017432.3	NP_059128.2	Q86YD1	PTOV1_HUMAN	prostate tumor overexpressed 1	253	Interaction with FLOT1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|plasma membrane				endometrium(5)|kidney(3)|large_intestine(2)|lung(5)|ovary(1)	16		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.0132)		TCCAGATCGTCAACAACAAGT	0.617000													4	18					0	0	1	0	0
HOXB8	3218	broad.mit.edu	37	17	46690726	46690726	+	Silent	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr17:46690726G>A	ENST00000239144.4	-	2	804	c.570C>T	c.(568-570)gtC>gtT	p.V190V	HOXB7_ENST00000567101.2_Intron|HOXB8_ENST00000576562.1_Silent_p.V189V	NM_024016.3	NP_076921.1	P17481	HXB8_HUMAN	homeobox B8	190						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|lung(8)|urinary_tract(2)	11						ACCAGATTTTGACCTGTCTCT	0.507000													12	93					0	0	1	0	0
TUBA1A	7846	broad.mit.edu	37	12	49580200	49580200	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr12:49580200C>G	ENST00000301071.7	-	3	612	c.268G>C	c.(268-270)Gag>Cag	p.E90Q	TUBA1A_ENST00000550767.1_Missense_Mutation_p.E55Q|TUBA1A_ENST00000546918.1_Silent_p.L140L|TUBA1A_ENST00000295766.5_Missense_Mutation_p.E90Q	NM_001270400.1|NM_006009.3	NP_001257329.1|NP_006000.2	Q71U36	TBA1A_HUMAN	tubulin, alpha 1a	90					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|structural molecule activity			stomach(1)|upper_aerodigestive_tract(1)	2						ATAAGTTGCTCAGGGTGGAAG	0.567000													12	117					0	0	1	0	0
OSGIN1	29948	broad.mit.edu	37	16	83999371	83999371	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr16:83999371C>T	ENST00000343939.2	+	7	1825	c.1442C>T	c.(1441-1443)tCc>tTc	p.S481F	OSGIN1_ENST00000393306.1_Missense_Mutation_p.S398F|OSGIN1_ENST00000361711.3_Missense_Mutation_p.S398F			Q9UJX0	OSGI1_HUMAN	oxidative stress induced growth inhibitor 1	481					cell differentiation|multicellular organismal development|negative regulation of cell growth		growth factor activity			autonomic_ganglia(1)|large_intestine(1)|lung(7)|prostate(2)|upper_aerodigestive_tract(1)	12						CTCATCGGCTCCCACCCCGAC	0.637000													4	19					0	0	1	0	0
ZNHIT2	741	broad.mit.edu	37	11	64884146	64884146	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr11:64884146C>T	ENST00000310597.4	-	1	1024	c.980G>A	c.(979-981)aGa>aAa	p.R327K		NM_014205.2	NP_055020.1	Q9UHR6	ZNHI2_HUMAN	zinc finger, HIT-type containing 2	327							metal ion binding			breast(1)|endometrium(1)|large_intestine(2)|lung(1)|urinary_tract(1)	6						TCGCTCTTCTCTAGCCACGGC	0.642000													5	36					0	0	1	0	0
MUT	4594	broad.mit.edu	37	6	49426828	49426828	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr6:49426828C>T	ENST00000274813.3	-	2	479	c.352G>A	c.(352-354)Gaa>Aaa	p.E118K		NM_000255.3	NP_000246.2	P22033	MUTA_HUMAN	methylmalonyl CoA mutase	118					fatty acid beta-oxidation	mitochondrial matrix	cobalamin binding|metal ion binding|methylmalonyl-CoA mutase activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(17)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	30	Lung NSC(77;0.0376)				Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TTATTGCTTTCTTCCACAGTA	0.383000													8	51					0	0	1	0	0
KIAA1683	80726	broad.mit.edu	37	19	18368240	18368240	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr19:18368240G>C	ENST00000392413.4	-	4	4069	c.3854C>G	c.(3853-3855)tCc>tGc	p.S1285C	KIAA1683_ENST00000600359.3_Missense_Mutation_p.S1052C|KIAA1683_ENST00000600328.3_Missense_Mutation_p.S1098C	NM_001145304.1	NP_001138776.1	Q9H0B3	K1683_HUMAN	KIAA1683							mitochondrion				breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						CTGGTAGGCGGAGGCCCAAGA	0.682000													3	20					0	0	1	0	0
WDR17	116966	broad.mit.edu	37	4	177100727	177100727	+	Missense_Mutation	SNP	C	C	G	rs34586919		TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr4:177100727C>G	ENST00000393643.2	+	30	4146	c.3894C>G	c.(3892-3894)ttC>ttG	p.F1298L	WDR17_ENST00000280190.4_Missense_Mutation_p.F1322L|WDR17_ENST00000507824.2_Missense_Mutation_p.F1297L|WDR17_ENST00000508596.1_Missense_Mutation_p.F1283L	NM_170710.4	NP_733828.2	Q8IZU2	WDR17_HUMAN	WD repeat domain 17	1322										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(18)|lung(46)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	92		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		TCAATCCATTCTGATAGAAGA	0.383000													5	70					0	0	1	0	0
NUP93	9688	broad.mit.edu	37	16	56857751	56857751	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr16:56857751G>C	ENST00000564887.1	+	6	1047	c.418G>C	c.(418-420)Gag>Cag	p.E140Q	NUP93_ENST00000542526.1_Missense_Mutation_p.E140Q|NUP93_ENST00000308159.5_Missense_Mutation_p.E263Q|NUP93_ENST00000569842.1_Missense_Mutation_p.E263Q	NM_001242795.1	NP_001229724.1	Q8N1F7	NUP93_HUMAN	nucleoporin 93kDa	263					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(2)|endometrium(6)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27						GGCGTACCTTGAGCAGAGGTA	0.542000													10	49					0	0	1	0	0
C5AR1	728	broad.mit.edu	37	19	47823550	47823550	+	Silent	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr19:47823550C>T	ENST00000355085.3	+	2	538	c.516C>T	c.(514-516)ttC>ttT	p.F172F		NM_001736.3	NP_001727.1	P21730	C5AR_HUMAN	complement component 5a receptor 1	172					activation of MAPK activity|activation of phospholipase C activity|cellular defense response|elevation of cytosolic calcium ion concentration|immune response|sensory perception of chemical stimulus	integral to plasma membrane	C5a anaphylatoxin receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(11)|ovary(2)|prostate(1)|skin(1)	20		all_cancers(25;2e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;0.000267)|OV - Ovarian serous cystadenocarcinoma(262;0.000618)|Epithelial(262;0.0142)|GBM - Glioblastoma multiforme(486;0.0242)		TACCCTCCTTCCTGTACCGGG	0.617000													4	60					0	0	1	0	0
SALL2	6297	broad.mit.edu	37	14	21993551	21993551	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr14:21993551G>A	ENST00000327430.3	-	2	605	c.311C>T	c.(310-312)tCc>tTc	p.S104F	SALL2_ENST00000450879.2_Missense_Mutation_p.S102F|SALL2_ENST00000317492.5_Missense_Mutation_p.S104F|SALL2_ENST00000538754.1_Missense_Mutation_p.S102F	NM_005407.1	NP_005398.1	Q9Y467	SALL2_HUMAN	spalt-like transcription factor 2	104							DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(6)|urinary_tract(2)	43	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		GGGCACGGAGGACCCAGAATC	0.622000													5	42					0	0	1	0	0
DNASE2B	58511	broad.mit.edu	37	1	84880516	84880516	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr1:84880516C>G	ENST00000370665.3	+	6	1084	c.1051C>G	c.(1051-1053)Caa>Gaa	p.Q351E	DNASE2B_ENST00000370662.3_Missense_Mutation_p.Q143E	NM_021233.2	NP_067056.2	Q8WZ79	DNS2B_HUMAN	deoxyribonuclease II beta	351					DNA metabolic process	lysosome	deoxyribonuclease II activity			endometrium(1)|lung(4)|skin(1)	6				all cancers(265;0.00303)|Epithelial(280;0.0112)|OV - Ovarian serous cystadenocarcinoma(397;0.0808)		CCAAGCATTTCAAGGATTAGT	0.403000													5	46					0	0	1	0	0
PDXDC1	23042	broad.mit.edu	37	16	15103587	15103587	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr16:15103587G>C	ENST00000396410.4	+	8	795	c.698G>C	c.(697-699)aGa>aCa	p.R233T	PDXDC1_ENST00000447912.2_Missense_Mutation_p.R142T|PDXDC1_ENST00000535621.2_Missense_Mutation_p.R233T|PDXDC1_ENST00000455313.2_Missense_Mutation_p.R210T|PDXDC1_ENST00000450288.2_Missense_Mutation_p.R205T|PDXDC1_ENST00000563679.1_Missense_Mutation_p.R251T|PDXDC1_ENST00000325823.7_Missense_Mutation_p.R218T|PDXDC1_ENST00000569715.1_Missense_Mutation_p.R206T	NM_015027.2	NP_055842.2	Q6P996	PDXD1_HUMAN	pyridoxal-dependent decarboxylase domain containing 1	233					carboxylic acid metabolic process		carboxy-lyase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(2)|liver(1)|lung(10)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38					Pyridoxal Phosphate(DB00114)	GAGCGAGGAAGACTGCCCCTG	0.418000													5	150					0	0	1	0	0
FAM65A	79567	broad.mit.edu	37	16	67575861	67575861	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr16:67575861C>T	ENST00000540839.3	+	14	1452	c.1232C>T	c.(1231-1233)tCa>tTa	p.S411L	FAM65A_ENST00000379312.3_Missense_Mutation_p.S395L|FAM65A_ENST00000422602.2_Missense_Mutation_p.S411L|FAM65A_ENST00000428437.2_Missense_Mutation_p.S405L|FAM65A_ENST00000042381.4_Missense_Mutation_p.S391L			Q6ZS17	FA65A_HUMAN	family with sequence similarity 65, member A	395						cytoplasm	binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	39		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)		CCACAGCTCTCAGGCACTGCC	0.622000													4	42					0	0	1	0	0
TUBA1A	7846	broad.mit.edu	37	12	49579389	49579389	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr12:49579389C>G	ENST00000301071.7	-	4	1104	c.760G>C	c.(760-762)Gaa>Caa	p.E254Q	TUBA1A_ENST00000550767.1_Missense_Mutation_p.E219Q|TUBA1A_ENST00000295766.5_Missense_Mutation_p.E254Q	NM_001270400.1|NM_006009.3	NP_001257329.1|NP_006000.2	Q71U36	TBA1A_HUMAN	tubulin, alpha 1a	254					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|structural molecule activity			stomach(1)|upper_aerodigestive_tract(1)	2						GTCTGGAATTCTGTCAGGTCA	0.498000													6	55					0	0	1	0	0
C17orf80	55028	broad.mit.edu	37	17	71232313	71232313	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr17:71232313C>T	ENST00000359042.2	+	3	886	c.692C>T	c.(691-693)tCt>tTt	p.S231F	C17orf80_ENST00000268942.8_Missense_Mutation_p.S231F|C17orf80_ENST00000577615.1_Missense_Mutation_p.S231F|C17orf80_ENST00000582793.1_Intron|C17orf80_ENST00000255557.4_Missense_Mutation_p.S231F|C17orf80_ENST00000535032.2_Missense_Mutation_p.S231F|C17orf80_ENST00000426147.2_Missense_Mutation_p.S231F|FAM104A_ENST00000583178.1_Intron	NM_017941.4	NP_060411	Q9BSJ5	CQ080_HUMAN	chromosome 17 open reading frame 80	231						integral to membrane				kidney(1)|large_intestine(5)|lung(2)|skin(2)|stomach(2)|urinary_tract(2)	14			LUSC - Lung squamous cell carcinoma(166;0.197)			TGTCATATTTCTCCAAAGAAT	0.403000													23	48					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152642879	152642879	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr6:152642879C>T	ENST00000367255.5	-	83	16661	c.16060G>A	c.(16060-16062)Gat>Aat	p.D5354N	SYNE1_ENST00000448038.1_Missense_Mutation_p.D5283N|SYNE1_ENST00000341594.5_Missense_Mutation_p.D5027N|SYNE1_ENST00000265368.4_Missense_Mutation_p.D5354N|SYNE1_ENST00000423061.1_Missense_Mutation_p.D5283N	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5354					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AGTTGAGCATCTATTTCTATT	0.368000										HNSCC(10;0.0054)			5	42					0	0	1	0	0
MINK1	50488	broad.mit.edu	37	17	4795963	4795963	+	Silent	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr17:4795963C>T	ENST00000355280.6	+	19	2407	c.2211C>T	c.(2209-2211)ctC>ctT	p.L737L	MINK1_ENST00000453408.3_Silent_p.L717L|MINK1_ENST00000347992.7_Silent_p.L700L	NM_001024937.3|NM_015716.4|NM_153827.4	NP_001020108.1|NP_056531.1|NP_722549.2	Q8N4C8	MINK1_HUMAN	misshapen-like kinase 1	737					JNK cascade	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)|stomach(1)	6						ACCCCGACCTCAGGAGGAGCG	0.677000													8	37					0	0	1	0	0
SRMS	6725	broad.mit.edu	37	20	62172280	62172280	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr20:62172280G>A	ENST00000217188.1	-	8	1398	c.1358C>T	c.(1357-1359)gCg>gTg	p.A453V		NM_080823.2	NP_543013.1	Q9H3Y6	SRMS_HUMAN	src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites	453	Protein kinase.		A -> T (in dbSNP:rs310655).				ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(9)|prostate(2)|stomach(1)	19	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;9.69e-09)|all cancers(9;5.84e-08)|BRCA - Breast invasive adenocarcinoma(10;3.63e-06)			GTAGACCTCCGCCGGGCAGGC	0.692000													4	66					0	0	1	0	0
KIF3C	3797	broad.mit.edu	37	2	26152240	26152240	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr2:26152240C>A	ENST00000264712.3	-	7	2801	c.2222G>T	c.(2221-2223)aGg>aTg	p.R741M	KIF3C_ENST00000405914.1_Missense_Mutation_p.R741M	NM_002254.6	NP_002245	O14782	KIF3C_HUMAN	kinesin family member 3C	741	Globular (Potential).				blood coagulation|microtubule-based movement	cytosol|kinesin complex|microtubule	ATP binding|microtubule motor activity			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(8)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCGCATGAGCCTCTCCATGTG	0.512000													11	56					4.68919e-08	5.11548e-08	1	1	0
MUC4	4585	broad.mit.edu	37	3	195484071	195484071	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr3:195484071C>G	ENST00000463781.3	-	18	15574	c.15115G>C	c.(15115-15117)Gag>Cag	p.E5039Q	MUC4_ENST00000475231.1_Missense_Mutation_p.E4987Q|MUC4_ENST00000346145.4_Missense_Mutation_p.E803Q|MUC4_ENST00000349607.4_Missense_Mutation_p.E752Q	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	1796					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		CACTGGCTCTCTGCATTGCAA	0.572000													8	44					0	0	1	0	0
BRD7	29117	broad.mit.edu	37	16	50357509	50357509	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr16:50357509C>G	ENST00000394688.3	-	12	1591	c.1432G>C	c.(1432-1434)Gag>Cag	p.E478Q	BRD7_ENST00000394689.2_Missense_Mutation_p.E478Q			Q9NPI1	BRD7_HUMAN	bromodomain containing 7	478					cell cycle|negative regulation of cell proliferation|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of histone acetylation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|nucleus	histone acetyl-lysine binding|p53 binding|transcription coactivator activity|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(7)|prostate(2)|urinary_tract(2)	22		all_cancers(37;0.0127)				ATCTCCATCTCTTGTAGGGTC	0.398000													10	88					0	0	1	0	0
CSN3	1448	broad.mit.edu	37	4	71114859	71114859	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr4:71114859C>T	ENST00000304954.3	+	4	318	c.232C>T	c.(232-234)Cgc>Tgc	p.R78C		NM_005212.2	NP_005203.2	P07498	CASK_HUMAN	casein kappa	78						extracellular region	protein binding			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	18						ATATGTGCCTCGCACATATTA	0.448000													9	33					0	0	1	0	0
CAND1	55832	broad.mit.edu	37	12	67696264	67696264	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr12:67696264G>C	ENST00000545606.1	+	8	1599	c.1162G>C	c.(1162-1164)Gag>Cag	p.E388Q		NM_018448.3	NP_060918.2	Q86VP6	CAND1_HUMAN	cullin-associated and neddylation-dissociated 1	388					cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(12)|prostate(1)|skin(2)|stomach(1)	35			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)		AGAGCGTGAAGAGAATGTAAA	0.438000													12	124					0	0	1	0	0
TNFRSF11A	8792	broad.mit.edu	37	18	60015412	60015412	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr18:60015412G>C	ENST00000586569.1	+	2	125	c.87G>C	c.(85-87)caG>caC	p.Q29H	TNFRSF11A_ENST00000269485.7_Missense_Mutation_p.Q29H	NM_001270949.1|NM_003839.3	NP_001257878.1|NP_003830.1	Q9Y6Q6	TNR11_HUMAN	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	29					adaptive immune response|cell-cell signaling|circadian temperature homeostasis|monocyte chemotaxis|osteoclast differentiation|positive regulation of cell proliferation|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of fever generation by positive regulation of prostaglandin secretion|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|response to interleukin-1|response to lipopolysaccharide	external side of plasma membrane|integral to membrane	metal ion binding|tumor necrosis factor receptor activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(5)|lung(13)|skin(3)|upper_aerodigestive_tract(1)	29		Colorectal(73;0.188)				TGGCTTTGCAGATCGCTCCTC	0.463000													8	42					0	0	1	0	0
EOGT	285203	broad.mit.edu	37	3	69050835	69050835	+	Silent	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr3:69050835G>C	ENST00000383701.3	-	9	1393	c.651C>G	c.(649-651)ctC>ctG	p.L217L	EOGT_ENST00000540764.1_Silent_p.L116L|EOGT_ENST00000295571.5_Silent_p.L217L|EOGT_ENST00000540955.1_Intron	NM_001278689.1	NP_001265618.1			EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase																		GTCTGAAGTTGAGCTGAGTAT	0.338000													14	75					0	0	1	0	0
ZNF324B	388569	broad.mit.edu	37	19	58966785	58966785	+	Silent	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr19:58966785C>T	ENST00000391696.1	+	3	1376	c.444C>T	c.(442-444)atC>atT	p.I148I	ZNF324B_ENST00000545523.1_Silent_p.I158I|ZNF324B_ENST00000336614.4_Silent_p.I158I			Q6AW86	Z324B_HUMAN	zinc finger protein 324B	158					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		AGGCCAGCATCAGCCTGCGAC	0.657000													6	46					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90455131	90455131	+	Splice_Site	SNP	C	C	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr6:90455131C>A	ENST00000369393.3	-	29	4155		c.e29-1		MDN1_ENST00000428876.1_Splice_Site			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)						protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GACAATTTACCTATCCAAGGA	0.403000													4	53					0.00909568	0.00936478	1	1	0
LGR5	8549	broad.mit.edu	37	12	71960661	71960661	+	Missense_Mutation	SNP	G	G	T	rs148862507	byFrequency	TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr12:71960661G>T	ENST00000266674.5	+	11	1350	c.1039G>T	c.(1039-1041)Gtc>Ttc	p.V347F	LGR5_ENST00000540815.2_Missense_Mutation_p.V323F|LGR5_ENST00000536515.1_Missense_Mutation_p.V275F			O75473	LGR5_HUMAN	leucine-rich repeat containing G protein-coupled receptor 5	347						integral to plasma membrane	protein-hormone receptor activity	p.V347L(1)	NUP107/LGR5(2)	endometrium(2)|kidney(3)|large_intestine(2)|lung(24)|ovary(1)|pancreas(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	48						TCCTCAAACCGTCTGCAATCA	0.403000													7	52					0.27861	0.280221	1	1	0
HTR1E	3354	broad.mit.edu	37	6	87726069	87726069	+	Silent	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr6:87726069C>T	ENST00000305344.5	+	2	1720	c.1017C>T	c.(1015-1017)atC>atT	p.I339I		NM_000865.2	NP_000856.1	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled						G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			breast(3)|endometrium(2)|kidney(3)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(3)	41		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	ATTCTCTGATCAACCCTCTGC	0.423000													15	92					0	0	1	0	0
ABCA1	19	broad.mit.edu	37	9	107599778	107599778	+	Silent	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr9:107599778C>G	ENST00000374736.3	-	10	1519	c.1125G>C	c.(1123-1125)ctG>ctC	p.L375L		NM_005502.3	NP_005493.2	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 1	375					Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(31)|liver(1)|lung(40)|ovary(5)|pancreas(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	115				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GCAGCGGCTTCAGAGCTTTCC	0.507000													8	33					0	0	1	0	0
EPM2AIP1	9852	broad.mit.edu	37	3	37033509	37033509	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr3:37033509G>C	ENST00000322716.5	-	1	1286	c.1060C>G	c.(1060-1062)Cta>Gta	p.L354V		NM_014805.3	NP_055620.1	Q7L775	EPMIP_HUMAN	EPM2A (laforin) interacting protein 1	354						endoplasmic reticulum				breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|liver(1)|lung(12)|ovary(2)	27						TCTTTTCTTAGAGAGAATATT	0.403000													9	108					0	0	1	0	0
ARHGAP10	79658	broad.mit.edu	37	4	148886219	148886219	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr4:148886219G>C	ENST00000336498.3	+	17	1734	c.1495G>C	c.(1495-1497)Gta>Cta	p.V499L	ARHGAP10_ENST00000414545.2_Missense_Mutation_p.V148L	NM_024605.3	NP_078881.3	A1A4S6	RHG10_HUMAN	Rho GTPase activating protein 10	499	Rho-GAP.				apoptosis|filopodium assembly|regulation of apoptosis|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm|plasma membrane	cytoskeletal adaptor activity|SH3 domain binding			autonomic_ganglia(2)|endometrium(5)|kidney(2)|large_intestine(4)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	33	all_hematologic(180;0.151)	Renal(17;0.0166)		GBM - Glioblastoma multiforme(119;0.0423)		CCATTTCTTGGTACACAAACT	0.313000													3	43					0	0	1	0	0
CTC1	80169	broad.mit.edu	37	17	8139168	8139168	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr17:8139168C>T	ENST00000315684.8	-	7	1194	c.1187G>A	c.(1186-1188)cGa>cAa	p.R396Q		NM_025099.5	NP_079375.3	Q2NKJ3	CTC1_HUMAN	CTS telomere maintenance complex component 1	396					positive regulation of DNA replication|telomere maintenance	Stn1-Ten1 complex	protein binding|single-stranded DNA binding			NS(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(8)|ovary(1)|skin(4)	29						CACTCCAGGTCGCATCACCCG	0.562000													3	22					0	0	1	0	0
BOD1L1	259282	broad.mit.edu	37	4	13601280	13601280	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr4:13601280T>C	ENST00000040738.5	-	10	7379	c.7244A>G	c.(7243-7245)aAg>aGg	p.K2415R		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	2415							DNA binding										TGCAGAGGGCTTGTGGACTGA	0.577000													12	129					0	0	1	0	0
EFCAB5	374786	broad.mit.edu	37	17	28380717	28380717	+	Nonsense_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr17:28380717C>G	ENST00000394835.3	+	10	1937	c.1745C>G	c.(1744-1746)tCa>tGa	p.S582*	EFCAB5_ENST00000536908.2_Nonsense_Mutation_p.S526*|EFCAB5_ENST00000320856.5_Nonsense_Mutation_p.S582*|EFCAB5_ENST00000541045.1_Nonsense_Mutation_p.S239*|EFCAB5_ENST00000378738.3_Nonsense_Mutation_p.S582*|EFCAB5_ENST00000394832.2_Nonsense_Mutation_p.S582*	NM_198529.3	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5	582							calcium ion binding			breast(7)|endometrium(2)|kidney(4)|large_intestine(11)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	43						CACAAAGGGTCAATAGAAGGA	0.458000													22	79					0	0	1	0	0
KRT4	3851	broad.mit.edu	37	12	53207390	53207390	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr12:53207390G>C	ENST00000293774.4	-	1	945	c.675C>G	c.(673-675)ttC>ttG	p.F225L	KRT4_ENST00000551956.1_Missense_Mutation_p.F151L|KRT4_ENST00000458244.2_Missense_Mutation_p.F131L			B4DRS2	B4DRS2_HUMAN	keratin 4	151						keratin filament	structural molecule activity			endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(4)|prostate(2)|skin(2)	29						CCTTGTCGATGAAGGAGGCAA	0.587000													24	123					0	0	1	0	0
SYNRG	11276	broad.mit.edu	37	17	35936484	35936484	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr17:35936484G>C	ENST00000339208.6	-	8	996	c.856C>G	c.(856-858)Cag>Gag	p.Q286E	SYNRG_ENST00000585472.1_Missense_Mutation_p.Q207E|SYNRG_ENST00000588194.1_5'UTR|SYNRG_ENST00000502449.2_Missense_Mutation_p.Q208E|SYNRG_ENST00000394378.2_Missense_Mutation_p.Q208E|SYNRG_ENST00000346661.4_Missense_Mutation_p.Q286E|SYNRG_ENST00000345615.4_Missense_Mutation_p.Q208E|SYNRG_ENST00000591288.1_Missense_Mutation_p.Q208E	NM_001163544.1|NM_001163545.1|NM_007247.4	NP_001157016.1|NP_001157017.1|NP_009178.3	Q9UMZ2	SYNRG_HUMAN	synergin, gamma	286					endocytosis|intracellular protein transport	AP-1 adaptor complex	calcium ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						ATTCTGGGCTGAGCAGGATCC	0.413000													6	34					0	0	1	0	0
CTSV	1515	broad.mit.edu	37	9	99795261	99795261	+	Silent	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr9:99795261G>A	ENST00000259470.5	-	8	1224	c.975C>T	c.(973-975)atC>atT	p.I325I	CTSV_ENST00000538255.1_Silent_p.I325I	NM_001333.3	NP_001324.2			cathepsin V									p.I325I(2)									CTGCTGTGGCGATTCCACAGT	0.473000													14	42					0	0	1	0	0
C5orf45	51149	broad.mit.edu	37	5	179268950	179268950	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr5:179268950C>G	ENST00000518219.1	-	5	417	c.406G>C	c.(406-408)Gag>Cag	p.E136Q	C5orf45_ENST00000292586.6_Missense_Mutation_p.E136Q|C5orf45_ENST00000523267.1_Intron|C5orf45_ENST00000521333.1_Intron|C5orf45_ENST00000403396.2_Missense_Mutation_p.E178Q|C5orf45_ENST00000376931.2_Missense_Mutation_p.E81Q|C5orf45_ENST00000523084.1_Missense_Mutation_p.E2Q|C5orf45_ENST00000518235.1_Missense_Mutation_p.E136Q|C5orf45_ENST00000520698.1_Missense_Mutation_p.E81Q			Q6NTE8	CE045_HUMAN	chromosome 5 open reading frame 45	136										breast(2)|endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)	12						CCTGGCTCCTCCATTTTGGAT	0.557000													18	245					0	0	1	0	0
MCF2L2	23101	broad.mit.edu	37	3	182910873	182910873	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr3:182910873C>T	ENST00000328913.3	-	27	3227	c.2930G>A	c.(2929-2931)gGa>gAa	p.G977E	MCF2L2_ENST00000473233.1_Missense_Mutation_p.G977E|MCF2L2_ENST00000468976.1_5'UTR	NM_015078.2	NP_055893	Q86YR7	MF2L2_HUMAN	MCF.2 cell line derived transforming sequence-like 2	977					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(25)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			GGATCCTGCTCCACTGCCTTT	0.512000													5	87					0	0	1	0	0
RBM48	84060	broad.mit.edu	37	7	92164070	92164070	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr7:92164070C>T	ENST00000481551.1	+	4	844	c.803C>T	c.(802-804)tCa>tTa	p.S268L	RBM48_ENST00000265732.5_Missense_Mutation_p.S268L			Q5RL73	CG064_HUMAN	RNA binding motif protein 48	268							nucleotide binding										ATTACGTCTTCAGAGGCAGTT	0.423000													7	31					0	0	1	0	0
UBR1	197131	broad.mit.edu	37	15	43351354	43351354	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr15:43351354C>G	ENST00000290650.4	-	9	1100	c.1022G>C	c.(1021-1023)aGa>aCa	p.R341T	UBR1_ENST00000382177.2_Missense_Mutation_p.R341T	NM_174916.2	NP_777576.1	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin 1	341					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			NS(2)|endometrium(2)|kidney(7)|large_intestine(12)|lung(25)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	58		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)		AGGTTCTTCTCTAAGGCATGC	0.378000													6	70					0	0	1	0	0
B3GAT2	135152	broad.mit.edu	37	6	71603972	71603972	+	Silent	SNP	G	G	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr6:71603972G>T	ENST00000230053.6	-	2	1203	c.595C>A	c.(595-597)Cga>Aga	p.R199R		NM_080742.2	NP_542780.1	Q9NPZ5	B3GA2_HUMAN	beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)	199					carbohydrate biosynthetic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|metal ion binding	p.R199G(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(2)|urinary_tract(1)	16						CGGGTGGTTCGCATCTATAAA	0.502000													4	26					0.00024832	0.000258729	1	1	0
GDF5	8200	broad.mit.edu	37	20	34025208	34025208	+	Silent	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr20:34025208G>A	ENST00000374372.1	-	3	1004	c.501C>T	c.(499-501)atC>atT	p.I167I	GDF5_ENST00000374369.3_Silent_p.I167I			P43026	GDF5_HUMAN	growth differentiation factor 5	167					cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(9)|skin(3)	26	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)			CGTGGGGTGTGATGGGGGGTG	0.632000													10	45					0	0	1	0	0
WDR76	79968	broad.mit.edu	37	15	44120502	44120502	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr15:44120502C>T	ENST00000263795.6	+	2	470	c.400C>T	c.(400-402)Ctc>Ttc	p.L134F	WDR76_ENST00000381246.2_Missense_Mutation_p.L70F	NM_001167941.1|NM_024908.3	NP_001161413.1|NP_079184.2	Q9H967	WDR76_HUMAN	WD repeat domain 76	134										breast(1)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(2)	20		all_cancers(109;3.26e-11)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.61e-06)|all_lung(180;1.5e-05)|Melanoma(134;0.0417)		all cancers(107;3.78e-21)|GBM - Glioblastoma multiforme(94;5.04e-07)		TGCGATGAATCTCAGTGTTGA	0.433000													6	44					0	0	1	0	0
ZAP70	7535	broad.mit.edu	37	2	98340718	98340718	+	Silent	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr2:98340718C>T	ENST00000264972.5	+	3	434	c.219C>T	c.(217-219)ggC>ggT	p.G73G		NM_001079.3	NP_001070.2	P43403	ZAP70_HUMAN	zeta-chain (TCR) associated protein kinase 70kDa	73	SH2 1.				immune response|intracellular protein kinase cascade|positive thymic T cell selection|T cell receptor signaling pathway	cytosol|T cell receptor complex	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	29						CCATTGCCGGCGGCAAAGCGC	0.677000													7	6					0	0	1	0	0
MAS1L	116511	broad.mit.edu	37	6	29455303	29455303	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr6:29455303G>T	ENST00000377127.3	-	1	435	c.377C>A	c.(376-378)tCg>tAg	p.S126*		NM_052967.1	NP_443199.1	P35410	MAS1L_HUMAN	MAS1 oncogene-like	126						cytoplasm|integral to membrane|nucleus|plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(7)|pancreas(1)|prostate(2)|skin(2)	28						CCCCACTGCCGAGCAGCAAAG	0.502000													6	40					2.0095e-06	2.16503e-06	1	1	0
FAM49B	51571	broad.mit.edu	37	8	130859062	130859062	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr8:130859062A>G	ENST00000519824.2	-	11	1172	c.899T>C	c.(898-900)cTa>cCa	p.L300P	FAM49B_ENST00000522746.1_Missense_Mutation_p.L300P|FAM49B_ENST00000519540.1_Missense_Mutation_p.L300P|FAM49B_ENST00000522941.1_Missense_Mutation_p.L154P|FAM49B_ENST00000517654.1_Missense_Mutation_p.L300P|FAM49B_ENST00000523509.1_Missense_Mutation_p.L300P|FAM49B_ENST00000401979.2_Missense_Mutation_p.L300P|FAM49B_ENST00000522250.1_Missense_Mutation_p.L154P|FAM49B_ENST00000519110.1_Missense_Mutation_p.L300P	NM_016623.4	NP_057707.3	Q9NUQ9	FA49B_HUMAN	family with sequence similarity 49, member B	300										kidney(1)|large_intestine(6)|lung(4)|prostate(1)	12	Ovarian(5;0.000567)|Esophageal squamous(12;0.00693)|Acute lymphoblastic leukemia(118;0.155)		LUAD - Lung adenocarcinoma(14;0.0989)			GAGAGCATTTAGAAGACCTTC	0.333000													5	35					0	0	1	0	0
KIF3C	3797	broad.mit.edu	37	2	26152239	26152239	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr2:26152239C>A	ENST00000264712.3	-	7	2802	c.2223G>T	c.(2221-2223)agG>agT	p.R741S	KIF3C_ENST00000405914.1_Missense_Mutation_p.R741S	NM_002254.6	NP_002245	O14782	KIF3C_HUMAN	kinesin family member 3C	741	Globular (Potential).				blood coagulation|microtubule-based movement	cytosol|kinesin complex|microtubule	ATP binding|microtubule motor activity			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(8)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ATCGCATGAGCCTCTCCATGT	0.517000													11	53					4.68919e-08	5.11548e-08	1	1	0
AHNAK2	113146	broad.mit.edu	37	14	105404438	105404438	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr14:105404438C>T	ENST00000333244.5	-	7	17469	c.17350G>A	c.(17350-17352)Gaa>Aaa	p.E5784K	AHNAK2_ENST00000557457.1_Missense_Mutation_p.E782K	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	5784						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCTTTGCTTTCATCGTCAGCT	0.517000													8	28					0	0	1	0	0
ROBO3	64221	broad.mit.edu	37	11	124747180	124747180	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr11:124747180G>C	ENST00000397801.1	+	19	3013	c.2821G>C	c.(2821-2823)Gag>Cag	p.E941Q	ROBO3_ENST00000538940.1_Missense_Mutation_p.E919Q|ROBO3_ENST00000525482.1_Intron	NM_022370.3	NP_071765.2	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3 (Drosophila)	941					axon midline choice point recognition	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	35	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		CCCGCACTCAGAGGGCCTCTC	0.617000													19	53					0	0	1	0	0
ZNF28	7576	broad.mit.edu	37	19	53304827	53304827	+	Nonstop_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr19:53304827C>G	ENST00000594602.1	-	5	490	c.389G>C	c.(388-390)tGa>tCa	p.*130S	ZNF28_ENST00000457749.2_Missense_Mutation_p.E91Q|ZNF28_ENST00000438150.2_Missense_Mutation_p.E38Q|ZNF28_ENST00000360272.4_Missense_Mutation_p.E38Q|ZNF28_ENST00000414252.2_Missense_Mutation_p.E38Q|ZNF28_ENST00000339844.6_Nonstop_Mutation_p.*80S			P17035	ZNF28_HUMAN	zinc finger protein 28	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|liver(1)|lung(10)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(134;0.0386)|Lung(386;0.145)		ATGTCTTTCTCAATTTTCTGG	0.423000													60	206					0	0	1	0	0
TMEM202	338949	broad.mit.edu	37	15	72691086	72691086	+	Silent	SNP	G	G	A	rs148667101	byFrequency	TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr15:72691086G>A	ENST00000341689.3	+	2	228	c.174G>A	c.(172-174)acG>acA	p.T58T	TMEM202_ENST00000567679.1_Intron	NM_001080462.1	NP_001073931.1	A6NGA9	TM202_HUMAN	transmembrane protein 202	58						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(4)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	18						ACATCCGAACGCTCTGTGGCA	0.522000													10	57					0	0	1	0	0
CEP192	55125	broad.mit.edu	37	18	13071095	13071095	+	Silent	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr18:13071095C>T	ENST00000506447.1	+	28	5312	c.5232C>T	c.(5230-5232)ggC>ggT	p.G1744G	CEP192_ENST00000430049.2_Silent_p.G1269G|CEP192_ENST00000325971.8_Silent_p.G1148G	NM_032142.3	NP_115518.3	B7ZMF0	B7ZMF0_HUMAN	centrosomal protein 192kDa	1339										NS(1)|breast(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(36)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						TGTTAAAAGGCGAAGTCATTT	0.398000													14	71					0	0	1	0	0
TNNC2	7125	broad.mit.edu	37	20	44453228	44453228	+	Silent	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr20:44453228G>A	ENST00000372557.1	-	4	267	c.60C>T	c.(58-60)atC>atT	p.I20I	TNNC2_ENST00000372555.3_Silent_p.I35I			P02585	TNNC2_HUMAN	troponin C type 2 (fast)	35	EF-hand 1.				muscle filament sliding|regulation of muscle contraction|skeletal muscle contraction	cytosol|troponin complex	calcium ion binding			endometrium(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	5		Myeloproliferative disorder(115;0.0122)				CCTTGACGCTGATGTCCCCAC	0.607000													6	33					0	0	1	0	0
IGFN1	91156	broad.mit.edu	37	1	201184692	201184692	+	Silent	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr1:201184692G>A	ENST00000335211.4	+	15	9151	c.9021G>A	c.(9019-9021)gtG>gtA	p.V3007V	IGFN1_ENST00000451870.2_Silent_p.V550V|IGFN1_ENST00000295591.8_Silent_p.V167V	NM_001164586.1	NP_001158058.1			immunoglobulin-like and fibronectin type III domain containing 1											autonomic_ganglia(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						CTCCAGATGTGACAGAGAAAC	0.537000													6	37					0	0	1	0	0
OR4M1	441670	broad.mit.edu	37	14	20248624	20248624	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr14:20248624C>T	ENST00000315957.4	+	1	224	c.143C>T	c.(142-144)aCc>aTc	p.T48I		NM_001005500.1	NP_001005500.1	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M, member 1	48					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(32)|prostate(1)|skin(2)	42	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ATCATTTGCACCATCAGGCTA	0.428000													17	281					0	0	1	0	0
WAC	51322	broad.mit.edu	37	10	28903528	28903528	+	Silent	SNP	G	G	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr10:28903528G>T	ENST00000375664.4	+	11	1944	c.1335G>T	c.(1333-1335)gtG>gtT	p.V445V	WAC_ENST00000375646.1_Silent_p.V338V|WAC_ENST00000354911.4_Silent_p.V490V|WAC_ENST00000347934.4_Silent_p.V387V			Q9BTA9	WAC_HUMAN	WW domain containing adaptor with coiled-coil						cell cycle checkpoint|histone H2B conserved C-terminal lysine ubiquitination|histone monoubiquitination|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nuclear speck	chromatin binding|RNA polymerase II core binding			NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|urinary_tract(1)	32						AAGGACCAGTGTCACAGTCAG	0.473000													8	41					0.0381472	0.0388165	1	1	0
URGCP	55665	broad.mit.edu	37	7	43917824	43917824	+	Nonsense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr7:43917824G>C	ENST00000336086.6	-	4	3345	c.1109C>G	c.(1108-1110)tCa>tGa	p.S370*	URGCP_ENST00000497914.1_5'UTR|URGCP_ENST00000443736.1_Nonsense_Mutation_p.S370*|URGCP_ENST00000447717.3_Nonsense_Mutation_p.S370*|URGCP_ENST00000223341.7_Nonsense_Mutation_p.S370*|URGCP-MRPS24_ENST00000603700.1_Intron|URGCP_ENST00000402306.3_Nonsense_Mutation_p.S404*|URGCP_ENST00000453200.1_Nonsense_Mutation_p.S413*			Q8TCY9	URGCP_HUMAN	upregulator of cell proliferation	413					cell cycle	centrosome|nucleus	GTP binding			breast(3)|endometrium(4)|kidney(2)|large_intestine(3)|liver(1)|lung(13)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						CAGGACATGTGAGTGGTCTAT	0.512000													6	111					0	0	1	0	0
HPS5	11234	broad.mit.edu	37	11	18319125	18319125	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr11:18319125C>T	ENST00000396253.3	-	10	1424	c.962G>A	c.(961-963)aGa>aAa	p.R321K	HPS5_ENST00000438420.2_Missense_Mutation_p.R321K|HPS5_ENST00000349215.3_Missense_Mutation_p.R435K|HPS5_ENST00000531848.1_Missense_Mutation_p.R321K	NM_007216.3	NP_009147.3	Q9UPZ3	HPS5_HUMAN	Hermansky-Pudlak syndrome 5	435						cytosol				breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30						AATGGAGCTTCTTCTACTGCT	0.373000									Hermansky-Pudlak syndrome				5	38					0	0	1	0	0
LRRC34	151827	broad.mit.edu	37	3	169514662	169514662	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr3:169514662C>T	ENST00000522526.2	-	7	1120	c.683G>A	c.(682-684)cGc>cAc	p.R228H	LRRC34_ENST00000524327.1_5'UTR|LRRC34_ENST00000446859.1_Missense_Mutation_p.R260H|LRRC34_ENST00000522830.1_Missense_Mutation_p.R199H|LRRC34_ENST00000316515.7_Missense_Mutation_p.R215H			Q8IZ02	LRC34_HUMAN	leucine rich repeat containing 34	215										breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|upper_aerodigestive_tract(2)	10	all_cancers(22;4.12e-22)|all_epithelial(15;7.54e-27)|all_lung(20;1.63e-16)|Lung NSC(18;6.92e-16)|Ovarian(172;0.000223)|Breast(254;0.197)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00676)			TTTCAACATGCGGCCTACATG	0.328000													3	55					0	0	1	0	0
C12orf55	144535	broad.mit.edu	37	12	97051864	97051864	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr12:97051864C>G	ENST00000524981.4	+	37	5328	c.5305C>G	c.(5305-5307)Cag>Gag	p.Q1769E						chromosome 12 open reading frame 55																		TCTTGCCATTCAGTTCAATAC	0.303000													8	49					0	0	1	0	0
GAB1	2549	broad.mit.edu	37	4	144359666	144359666	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr4:144359666G>A	ENST00000262995.4	+	4	1535	c.1108G>A	c.(1108-1110)Gac>Aac	p.D370N	GAB1_ENST00000262994.4_Missense_Mutation_p.D370N|GAB1_ENST00000505913.1_Missense_Mutation_p.D267N	NM_207123.2	NP_997006.1	Q13480	GAB1_HUMAN	GRB2-associated binding protein 1	370					cell proliferation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	cytosol	SH3/SH2 adaptor activity			breast(3)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(10)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	30	all_hematologic(180;0.158)					CTCAGACACTGACAGTAGTTA	0.483000													14	48					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124349173	124349173	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr12:124349173C>G	ENST00000409039.3	+	39	6611	c.6586C>G	c.(6586-6588)Cta>Gta	p.L2196V		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2196	AAA 2 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TGTGGATGCTCTATGGGTGGA	0.468000													3	40					0	0	1	0	0
UBA7	7318	broad.mit.edu	37	3	49845268	49845268	+	Silent	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr3:49845268C>T	ENST00000333486.3	-	21	2774	c.2616G>A	c.(2614-2616)gtG>gtA	p.V872V		NM_003335.2	NP_003326.2	P41226	UBA7_HUMAN	ubiquitin-like modifier activating enzyme 7	872					ISG15-protein conjugation|negative regulation of type I interferon production	cytosol	ATP binding|ISG15 activating enzyme activity|ligase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(15)|large_intestine(4)|lung(7)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;3.58e-06)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		GTGGCCCACTCACCACCTTAT	0.572000													4	17					0	0	1	0	0
PTBP3	9991	broad.mit.edu	37	9	115060143	115060143	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr9:115060143C>T	ENST00000334318.6	-	3	282	c.96G>A	c.(94-96)atG>atA	p.M32I	PTBP3_ENST00000343327.2_5'UTR|PTBP3_ENST00000458258.1_Missense_Mutation_p.M38I|PTBP3_ENST00000487997.1_Intron|PTBP3_ENST00000374257.1_Start_Codon_SNP_p.M1I|PTBP3_ENST00000374255.2_Missense_Mutation_p.M32I	NM_001163790.2|NM_005156.6	NP_001157262.1|NP_005147.3	O95758	ROD1_HUMAN	polypyrimidine tract binding protein 3	32					anatomical structure morphogenesis|mRNA processing	nucleus	nucleotide binding|RNA binding										TAGAACTATTCATGGTAAAAG	0.323000													18	60					0	0	1	0	0
SEC24A	10802	broad.mit.edu	37	5	134015330	134015330	+	Silent	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr5:134015330C>T	ENST00000398844.2	+	8	1581	c.1293C>T	c.(1291-1293)tgC>tgT	p.C431C	SEC24A_ENST00000322887.4_Silent_p.C431C	NM_021982.2	NP_068817.1	O95486	SC24A_HUMAN	SEC24 family member A	431	Zinc finger-like.				COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding			NS(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(13)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	36			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TTGTGAGATGCCGTTCATGCA	0.368000													4	92					0	0	1	0	0
HECTD1	25831	broad.mit.edu	37	14	31598196	31598196	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr14:31598196C>T	ENST00000399332.1	-	25	4869	c.4381G>A	c.(4381-4383)Gaa>Aaa	p.E1461K	HECTD1_ENST00000553700.1_Missense_Mutation_p.E1461K	NM_015382.2	NP_056197.2	Q9ULT8	HECD1_HUMAN	HECT domain containing E3 ubiquitin protein ligase 1	1461	Ser-rich.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			breast(10)|endometrium(7)|kidney(5)|large_intestine(12)|lung(23)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	70	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		AACTTCCTTTCAGCATTTTCA	0.458000													15	81					0	0	1	0	0
AP1G1	164	broad.mit.edu	37	16	71807214	71807214	+	Silent	SNP	G	G	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr16:71807214G>T	ENST00000299980.4	-	4	819	c.378C>A	c.(376-378)ctC>ctA	p.L126L	AP1G1_ENST00000569748.1_Silent_p.L126L|AP1G1_ENST00000423132.2_Silent_p.L126L|AP1G1_ENST00000433195.2_Silent_p.L149L|AP1G1_ENST00000393512.3_Silent_p.L126L	NM_001128.5	NP_001119.3	O43747	AP1G1_HUMAN	adaptor-related protein complex 1, gamma 1 subunit	126					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|recycling endosome	kinesin binding|protein transporter activity			breast(1)|endometrium(8)|large_intestine(6)|lung(7)|ovary(4)|pancreas(1)|urinary_tract(1)	28		Ovarian(137;0.125)				CCATGCAGCCGAGGGTACAAA	0.458000													8	50					2.17888e-05	2.31881e-05	1	1	0
CD55	1604	broad.mit.edu	37	1	207495849	207495849	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr1:207495849G>A	ENST00000367064.3	+	2	481	c.223G>A	c.(223-225)Gag>Aag	p.E75K	CD55_ENST00000367062.4_Missense_Mutation_p.E75K|CD55_ENST00000367063.2_Missense_Mutation_p.E75K|CD55_ENST00000391921.4_Missense_Mutation_p.E75K|CD55_ENST00000391920.4_Missense_Mutation_p.E75K|CD55_ENST00000367065.5_Missense_Mutation_p.E75K|CD55_ENST00000314754.8_Missense_Mutation_p.E75K|CD55_ENST00000367067.4_Missense_Mutation_p.E75K	NM_000574.3	NP_000565.1	P08174	DAF_HUMAN	CD55 molecule, decay accelerating factor for complement (Cromer blood group)	75	Sushi 1.				complement activation, classical pathway|elevation of cytosolic calcium ion concentration|innate immune response|respiratory burst	anchored to membrane|extracellular region|integral to plasma membrane|membrane raft|soluble fraction	receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	16					Chloramphenicol(DB00446)	AATTCCTGGCGAGAAGGACTC	0.423000													8	44					0	0	1	0	0
CDK4	1019	broad.mit.edu	37	12	58145064	58145064	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr12:58145064C>T	ENST00000257904.6	-	3	645	c.280G>A	c.(280-282)Gag>Aag	p.E94K	CDK4_ENST00000551888.1_Intron|CDK4_ENST00000540325.1_Intron|CDK4_ENST00000312990.6_Intron|CDK4_ENST00000549606.1_Intron	NM_000075.3	NP_000066.1	P11802	CDK4_HUMAN	cyclin-dependent kinase 4	94	Protein kinase.				cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|positive regulation of fibroblast proliferation|regulation of gene expression|response to drug|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane	ATP binding|cyclin-dependent protein kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|skin(2)	21	all_cancers(7;4.96e-69)|Lung NSC(6;5.5e-25)|all_lung(6;3.87e-23)|all_epithelial(6;1.66e-15)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;4.21e-120)|all cancers(5;3.75e-83)|BRCA - Breast invasive adenocarcinoma(9;0.0294)			TCTACATGCTCAAACACCAGG	0.527000			Mis			melanoma			Hereditary Melanoma				8	55					0	0	1	0	0
CYGB	114757	broad.mit.edu	37	17	74527171	74527171	+	Silent	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr17:74527171G>A	ENST00000293230.5	-	3	791	c.429C>T	c.(427-429)ttC>ttT	p.F143F	CYGB_ENST00000589145.1_Silent_p.F78F|PRCD_ENST00000592432.1_Intron|CYGB_ENST00000590175.1_Silent_p.F78F|CYGB_ENST00000589342.1_Intron	NM_134268.4	NP_599030.1	Q8WWM9	CYGB_HUMAN	cytoglobin	143	Globin.				response to oxidative stress	cytoplasm	heme binding|oxygen binding|oxygen transporter activity|peroxidase activity			breast(1)|endometrium(2)|large_intestine(1)|lung(2)|ovary(1)	7						TCTCAGGTGGGAAGTCACTGG	0.647000													7	24					0	0	1	0	0
F8	2157	broad.mit.edu	37	X	154157347	154157347	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chrX:154157347G>C	ENST00000360256.4	-	14	4918	c.4718C>G	c.(4717-4719)tCt>tGt	p.S1573C		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	1573	B.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	AGTCTTTGCAGAGCTTTCTGT	0.468000													49	81					0	0	1	0	0
KRT78	196374	broad.mit.edu	37	12	53237915	53237915	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr12:53237915G>C	ENST00000359499.4	-	6	690	c.679C>G	c.(679-681)Cag>Gag	p.Q227E	KRT78_ENST00000304620.4_Missense_Mutation_p.Q337E			Q8N1N4	K2C78_HUMAN	keratin 78	337	Coil 1B.|Rod.					keratin filament	protein binding|structural molecule activity			endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	18						TGCAGCCTCTGAATCTCTTGG	0.517000													17	97					0	0	1	0	0
ZNF423	23090	broad.mit.edu	37	16	49672222	49672222	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr16:49672222G>T	ENST00000561648.1	-	4	894	c.841C>A	c.(841-843)Cac>Aac	p.H281N	ZNF423_ENST00000262383.2_Missense_Mutation_p.H281N|ZNF423_ENST00000563137.2_Missense_Mutation_p.H221N|ZNF423_ENST00000562871.1_Missense_Mutation_p.H221N|ZNF423_ENST00000562520.1_Missense_Mutation_p.H221N|ZNF423_ENST00000567169.1_Missense_Mutation_p.H164N|ZNF423_ENST00000535559.1_Missense_Mutation_p.H164N	NM_001271620.1	NP_001258549.1	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	281					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				GTGAGCACGTGCTTCTCCAGC	0.597000													4	30					0.00024832	0.000258729	1	1	0
ZBTB22	9278	broad.mit.edu	37	6	33284271	33284271	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr6:33284271G>C	ENST00000431845.2	-	2	574	c.423C>G	c.(421-423)gaC>gaG	p.D141E	ZBTB22_ENST00000418724.1_Missense_Mutation_p.D141E	NM_005453.4	NP_005444.4	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	141					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(9)|ovary(2)|prostate(1)|urinary_tract(3)	21						CAGTGCACTTGTCCACAATGT	0.577000													9	72					0	0	1	0	0
ZNF12	7559	broad.mit.edu	37	7	6731177	6731177	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr7:6731177C>G	ENST00000405858.1	-	5	1937	c.1396G>C	c.(1396-1398)Gaa>Caa	p.E466Q	ZNF12_ENST00000404360.1_Missense_Mutation_p.E392Q|ZNF12_ENST00000342651.5_Missense_Mutation_p.E428Q|AC073343.13_ENST00000366167.2_RNA	NM_006956.2|NM_016265.3	NP_008887.2|NP_057349.2	P17014	ZNF12_HUMAN	zinc finger protein 12	466					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|endometrium(1)|large_intestine(1)|lung(7)|prostate(2)|upper_aerodigestive_tract(3)	16		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0231)		TCATTACATTCATAGGGTTTC	0.398000													7	91					0	0	1	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140347337	140347337	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr5:140347337C>T	ENST00000289269.5	+	1	1518	c.986C>T	c.(985-987)tCc>tTc	p.S329F	PCDHA10_ENST00000307360.5_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHAC1_ENST00000253807.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018899.5|NM_031883.2	NP_061722.1|NP_114089.1	Q9Y5I4	PCDC2_HUMAN		329	Cadherin 3.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGGAAGCCTCCTCCTACCAG	0.582000													3	23					0	0	1	0	0
ST8SIA5	29906	broad.mit.edu	37	18	44260223	44260223	+	Silent	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr18:44260223G>A	ENST00000315087.7	-	7	1573	c.913C>T	c.(913-915)Ctg>Ttg	p.L305L	ST8SIA5_ENST00000536490.1_Silent_p.L274L|ST8SIA5_ENST00000590497.1_5'UTR|ST8SIA5_ENST00000538168.1_Silent_p.L341L	NM_013305.4	NP_037437.2	O15466	SIA8E_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5	305					glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane				kidney(1)|large_intestine(10)|lung(7)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(2)	22						GCAGTGACCAGAATGAGGCCG	0.612000													5	69					0	0	1	0	0
RIMBP2	23504	broad.mit.edu	37	12	130926714	130926714	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr12:130926714C>T	ENST00000261655.4	-	8	1295	c.1132G>A	c.(1132-1134)Gat>Aat	p.D378N	RIMBP2_ENST00000535703.1_Missense_Mutation_p.D286N|RIMBP2_ENST00000536002.1_Missense_Mutation_p.D286N	NM_015347.4	NP_056162.4	O15034	RIMB2_HUMAN	RIMS binding protein 2	378						cell junction|synapse				NS(2)|breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(33)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	96	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		TGCAGCTCATCCGAGCTGCCC	0.642000													4	30					0	0	1	0	0
ATAD3B	83858	broad.mit.edu	37	1	1421164	1421164	+	Silent	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr1:1421164C>G	ENST00000308647.7	+	9	1025	c.909C>G	c.(907-909)gtC>gtG	p.V303V		NM_031921.4	NP_114127.3	Q5T9A4	ATD3B_HUMAN	ATPase family, AAA domain containing 3B	303							ATP binding|nucleoside-triphosphatase activity			endometrium(2)|large_intestine(1)|lung(3)|ovary(1)|skin(2)|urinary_tract(1)	10	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		TCCGGCAGGTCAGCCGGCGGC	0.647000													6	33					0	0	1	0	0
USP16	10600	broad.mit.edu	37	21	30403041	30403041	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr21:30403041G>C	ENST00000334352.4	+	4	418	c.187G>C	c.(187-189)Gaa>Caa	p.E63Q	USP16_ENST00000535828.1_Intron|USP16_ENST00000399975.3_Missense_Mutation_p.E63Q|USP16_ENST00000399976.2_Missense_Mutation_p.E63Q	NM_001032410.1	NP_001027582.1	Q9Y5T5	UBP16_HUMAN	ubiquitin specific peptidase 16	63					cell division|histone deubiquitination|mitosis|positive regulation of transcription, DNA-dependent|protein homotetramerization|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|histone binding|transcription coactivator activity|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(2)	34						TAAAGCTGAAGAAGAAACAGA	0.358000													5	69					0	0	1	0	0
SLITRK4	139065	broad.mit.edu	37	X	142718749	142718749	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chrX:142718749G>C	ENST00000381779.4	-	2	401	c.176C>G	c.(175-177)tCt>tGt	p.S59C	SLITRK4_ENST00000338017.4_Missense_Mutation_p.S59C|SLITRK4_ENST00000356928.1_Missense_Mutation_p.S59C	NM_001184749.2|NM_001184750.1|NM_173078.4	NP_001171678.1|NP_001171679.1|NP_775101.1	Q8IW52	SLIK4_HUMAN	SLIT and NTRK-like family, member 4	59						integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(11)|lung(27)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	60	Acute lymphoblastic leukemia(192;6.56e-05)					ATAAAAATTAGACCAAGGTGG	0.368000													9	39					0	0	1	0	0
CHRNA9	55584	broad.mit.edu	37	4	40351422	40351422	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr4:40351422C>T	ENST00000310169.2	+	4	1028	c.889C>T	c.(889-891)Ccc>Tcc	p.P297S		NM_017581.3	NP_060051.2	Q9UGM1	ACHA9_HUMAN	cholinergic receptor, nicotinic, alpha 9 (neuronal)	297					elevation of cytosolic calcium ion concentration|synaptic transmission	cell junction|postsynaptic membrane	calcium channel activity|receptor activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(3)|skin(4)|stomach(1)	33					Nicotine(DB00184)	AGAAAATGTGCCCCTGATAGG	0.498000													4	107					0	0	1	0	0
LIX1L	128077	broad.mit.edu	37	1	145498121	145498121	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr1:145498121C>G	ENST00000369308.3	+	5	786	c.712C>G	c.(712-714)Caa>Gaa	p.Q238E	RP11-315I20.1_ENST00000599147.1_RNA|RP11-315I20.1_ENST00000598354.1_RNA|RP11-315I20.1_ENST00000595494.1_RNA|RP11-315I20.1_ENST00000412239.1_RNA|RP11-315I20.1_ENST00000595518.1_RNA|RP11-315I20.1_ENST00000597144.1_RNA|RP11-315I20.1_ENST00000599626.1_RNA|RP11-315I20.1_ENST00000600340.1_RNA|RP11-315I20.1_ENST00000598103.1_RNA|RP11-315I20.1_ENST00000421764.1_RNA|RP11-315I20.1_ENST00000599469.1_RNA|RP11-315I20.1_ENST00000448561.1_RNA|RP11-315I20.1_ENST00000437797.1_RNA|RP11-315I20.1_ENST00000601726.1_RNA	NM_153713.1	NP_714924.1	Q8IVB5	LIX1L_HUMAN	Lix1 homolog (mouse)-like	238										large_intestine(4)|lung(6)|ovary(2)|skin(1)	13	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GACAGTTTTTCAACTGCTACA	0.468000													6	54					0	0	1	0	0
ZNHIT2	741	broad.mit.edu	37	11	64884137	64884137	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr11:64884137C>T	ENST00000310597.4	-	1	1033	c.989G>A	c.(988-990)cGa>cAa	p.R330Q		NM_014205.2	NP_055020.1	Q9UHR6	ZNHI2_HUMAN	zinc finger, HIT-type containing 2	330							metal ion binding			breast(1)|endometrium(1)|large_intestine(2)|lung(1)|urinary_tract(1)	6						AAGATGATCTCGCTCTTCTCT	0.642000													6	34					0	0	1	0	0
SPAG9	9043	broad.mit.edu	37	17	49133775	49133775	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr17:49133775C>T	ENST00000262013.7	-	3	701	c.493G>A	c.(493-495)Gag>Aag	p.E165K	RP11-481C4.1_ENST00000509833.1_RNA|SPAG9_ENST00000357122.4_Missense_Mutation_p.E165K|SPAG9_ENST00000505279.1_Missense_Mutation_p.E165K	NM_001130528.2	NP_001124000.1	O60271	JIP4_HUMAN	sperm associated antigen 9	165					positive regulation of cell migration|positive regulation of muscle cell differentiation|retrograde transport, endosome to Golgi|spermatogenesis	acrosomal vesicle|integral to membrane|perinuclear region of cytoplasm				NS(1)|breast(3)|endometrium(3)|kidney(4)|large_intestine(8)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(1)	37			BRCA - Breast invasive adenocarcinoma(22;4.24e-07)			AAACCCACCTCAGTGTGTCTT	0.303000													24	67					0	0	1	0	0
LCK	3932	broad.mit.edu	37	1	32745564	32745564	+	Silent	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr1:32745564C>T	ENST00000333070.4	+	11	1354	c.1254C>T	c.(1252-1254)ctC>ctT	p.L418L	LCK_ENST00000336890.5_Silent_p.L388L|LCK_ENST00000373564.3_Silent_p.L395L	NM_001042771.1	NP_001036236.1	P06239	LCK_HUMAN	lymphocyte-specific protein tyrosine kinase	388	Protein kinase.				activation of caspase activity|cellular zinc ion homeostasis|induction of apoptosis|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of T cell receptor signaling pathway|regulation of defense response to virus by virus|release of sequestered calcium ion into cytosol|response to drug|T cell costimulation|T cell differentiation|T cell receptor signaling pathway|viral reproduction	cytosol|Golgi apparatus|membrane raft|pericentriolar material|plasma membrane	ATP binding|ATPase binding|CD4 receptor binding|CD8 receptor binding|glycoprotein binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein kinase binding|protein serine/threonine phosphatase activity|SH2 domain binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	37		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)			Dasatinib(DB01254)	TAGCACGCCTCATTGAGGACA	0.547000			T	TRB@	T-ALL								7	44					0	0	1	0	0
PRODH2	58510	broad.mit.edu	37	19	36297420	36297420	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr19:36297420C>T	ENST00000301175.3	-	8	1158	c.1141G>A	c.(1141-1143)Ggt>Agt	p.G381S		NM_021232.1	NP_067055.1	Q9UF12	PROD2_HUMAN	proline dehydrogenase (oxidase) 2	381					glutamate biosynthetic process|proline catabolic process		proline dehydrogenase activity	p.G381S(1)		haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21	all_lung(56;2.87e-07)|Lung NSC(56;4.32e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			AGATATGCACCTCGTACCAGC	0.637000													6	64					0	0	1	0	0
KPNA6	23633	broad.mit.edu	37	1	32622970	32622970	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr1:32622970G>A	ENST00000373625.3	+	4	348	c.255G>A	c.(253-255)atG>atA	p.M85I	KPNA6_ENST00000545542.1_Missense_Mutation_p.M90I|KPNA6_ENST00000537234.1_Missense_Mutation_p.M82I|KPNA6_ENST00000469790.1_3'UTR	NM_012316.4	NP_036448.1	O60684	IMA7_HUMAN	karyopherin alpha 6 (importin alpha 7)	85					NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding			large_intestine(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				CAAGAGAGATGGTGGAGATGC	0.443000													4	32					0	0	1	0	0
GTPBP2	54676	broad.mit.edu	37	6	43589377	43589377	+	Missense_Mutation	SNP	C	C	T	rs2232218		TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr6:43589377C>T	ENST00000307126.5	-	12	1782	c.1783G>A	c.(1783-1785)Gaa>Aaa	p.E595K	GTPBP2_ENST00000476510.1_5'UTR|GTPBP2_ENST00000307114.7_Missense_Mutation_p.E507K	NM_019096.3	NP_061969.3	Q9BX10	GTPB2_HUMAN	GTP binding protein 2	595							GTP binding|GTPase activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|liver(1)|lung(3)|prostate(1)|skin(2)|urinary_tract(1)	18	all_cancers(18;9.36e-06)|Lung NSC(15;0.00161)|all_lung(25;0.004)		all cancers(41;0.000501)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0826)|OV - Ovarian serous cystadenocarcinoma(102;0.167)			GCCTGGGCTTCTCCTGCTGTA	0.552000													8	33					0	0	1	0	0
KIAA1429	25962	broad.mit.edu	37	8	95508104	95508104	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr8:95508104C>T	ENST00000297591.5	-	19	4474	c.4399G>A	c.(4399-4401)Gat>Aat	p.D1467N	KIAA1429_ENST00000437199.1_3'UTR	NM_015496.4	NP_056311.2	Q69YN4	VIR_HUMAN	KIAA1429	1467					mRNA processing|RNA splicing	nucleus				NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(16)|lung(28)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	66	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			AGATTGTCATCATCTTTTGAA	0.403000													9	44					0	0	1	0	0
TP53I11	9537	broad.mit.edu	37	11	44957160	44957160	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr11:44957160G>A	ENST00000533940.1	-	9	992	c.388C>T	c.(388-390)Cga>Tga	p.R130*	TP53I11_ENST00000308212.5_Nonsense_Mutation_p.R130*|TP53I11_ENST00000525680.1_Nonsense_Mutation_p.R130*|TP53I11_ENST00000395648.3_Nonsense_Mutation_p.R130*	NM_001258320.1	NP_001245249.1	O14683	P5I11_HUMAN	tumor protein p53 inducible protein 11	130					negative regulation of cell proliferation|response to stress	integral to membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(2)|ovary(1)	5						AGGGTCCATCGAATGATGACC	0.612000													4	15					0	0	1	0	0
CLCF1	23529	broad.mit.edu	37	11	67133001	67133001	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr11:67133001C>T	ENST00000312438.7	-	3	481	c.284G>A	c.(283-285)cGa>cAa	p.R95Q	CLCF1_ENST00000533438.1_Missense_Mutation_p.R85Q|CLCF1_ENST00000528474.1_Missense_Mutation_p.R85Q|AP003419.11_ENST00000543494.1_RNA	NM_013246.2	NP_037378.1	Q9UBD9	CLCF1_HUMAN	cardiotrophin-like cytokine factor 1	95					B cell differentiation|cytokine-mediated signaling pathway|JAK-STAT cascade|negative regulation of neuron apoptosis|positive regulation of astrocyte differentiation|positive regulation of B cell proliferation|positive regulation of immunoglobulin production|positive regulation of isotype switching to IgE isotypes|positive regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	ciliary neurotrophic factor receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity			endometrium(1)|urinary_tract(1)	2			BRCA - Breast invasive adenocarcinoma(15;2.39e-06)			ATTGAGGCTTCGCCACACCTC	0.607000													3	50					0	0	1	0	0
MTSS1	9788	broad.mit.edu	37	8	125601898	125601898	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr8:125601898C>A	ENST00000518547.1	-	5	821	c.348G>T	c.(346-348)aaG>aaT	p.K116N	MTSS1_ENST00000325064.5_Missense_Mutation_p.K116N|MTSS1_ENST00000378017.3_Missense_Mutation_p.K116N|MTSS1_ENST00000354184.4_5'UTR	NM_001282971.1|NM_014751.4	NP_001269900.1|NP_055566.3	O43312	MTSS1_HUMAN	metastasis suppressor 1	116	IMD.				actin cytoskeleton organization|cell adhesion|cellular component movement|filopodium assembly|transmembrane receptor protein tyrosine kinase signaling pathway	actin cytoskeleton|endocytic vesicle|ruffle	actin monomer binding|cytoskeletal adaptor activity|receptor binding|SH3 domain binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	37	Ovarian(258;0.00438)|all_neural(195;0.00459)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			TGGCCACTTTCTTCCATTCTT	0.488000													18	175					1.56452e-12	1.74505e-12	1	1	0
CHDH	55349	broad.mit.edu	37	3	53852098	53852098	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr3:53852098C>G	ENST00000315251.6	-	9	1928	c.1491G>C	c.(1489-1491)gaG>gaC	p.E497D		NM_018397.4	NP_060867.2	Q8NE62	CHDH_HUMAN	choline dehydrogenase						alcohol metabolic process		choline dehydrogenase activity|flavin adenine dinucleotide binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)	17		Hepatocellular(537;0.152)		BRCA - Breast invasive adenocarcinoma(193;0.000158)|KIRC - Kidney renal clear cell carcinoma(284;0.00588)|Kidney(284;0.00673)|OV - Ovarian serous cystadenocarcinoma(275;0.118)	Choline(DB00122)	AGGCATCTATCTCTTTATCTG	0.572000													3	56					0	0	1	0	0
PKP1	5317	broad.mit.edu	37	1	201292251	201292251	+	Silent	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr1:201292251C>T	ENST00000263946.3	+	10	1928	c.1677C>T	c.(1675-1677)agC>agT	p.S559S	PKP1_ENST00000352845.3_Silent_p.S559S|PKP1_ENST00000367324.3_Silent_p.S538S	NM_000299.3	NP_000290.2	Q13835	PKP1_HUMAN	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	559					cell adhesion|cellular component disassembly involved in apoptosis|multicellular organismal development	desmosome|intermediate filament|nucleus	intermediate filament binding|signal transducer activity|structural constituent of epidermis			NS(2)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|ovary(5)|prostate(1)	22						TGGGCAAGAGCAAGAAAGATG	0.592000													9	90					0	0	1	0	0
BOC	91653	broad.mit.edu	37	3	113004280	113004280	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr3:113004280C>G	ENST00000495514.1	+	19	3729	c.3025C>G	c.(3025-3027)Cac>Gac	p.H1009D	BOC_ENST00000355385.3_Missense_Mutation_p.H1009D|BOC_ENST00000273395.4_Missense_Mutation_p.H1010D			Q9BWV1	BOC_HUMAN	BOC cell adhesion associated, oncogene regulated	1009					cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	68			Epithelial(53;0.227)			CGACTCCACTCACCAGCTGCT	0.652000													3	39					0	0	1	0	0
CLIP1	6249	broad.mit.edu	37	12	122837326	122837326	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr12:122837326C>T	ENST00000358808.2	-	8	1469	c.1315G>A	c.(1315-1317)Gag>Aag	p.E439K	CLIP1_ENST00000540338.1_Missense_Mutation_p.E439K|CLIP1_ENST00000545889.1_Missense_Mutation_p.E140K|CLIP1_ENST00000537178.1_Missense_Mutation_p.E439K|CLIP1_ENST00000302528.7_Missense_Mutation_p.E439K|CLIP1_ENST00000361654.4_Missense_Mutation_p.E439K	NM_001247997.1|NM_002956.2	NP_001234926.1|NP_002947.1	P30622	CLIP1_HUMAN	CAP-GLY domain containing linker protein 1	439					mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			NS(1)|breast(5)|endometrium(4)|kidney(5)|large_intestine(16)|liver(1)|lung(21)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		TGAAGGTCCTCAACCTTCCTG	0.383000													18	50					0	0	1	0	0
SIPA1	6494	broad.mit.edu	37	11	65417106	65417106	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr11:65417106C>T	ENST00000394224.3	+	11	2896	c.2600C>T	c.(2599-2601)tCa>tTa	p.S867L	SIPA1_ENST00000527525.1_Missense_Mutation_p.S765L|SIPA1_ENST00000394227.3_Missense_Mutation_p.S765L|SIPA1_ENST00000534313.1_Missense_Mutation_p.S867L	NM_153253.29	NP_694985.29	Q96FS4	SIPA1_HUMAN	signal-induced proliferation-associated 1	867					cell proliferation|cytoskeleton organization|intracellular signal transduction|negative regulation of cell adhesion|negative regulation of cell cycle|negative regulation of cell growth	cytosol|endomembrane system|membrane|perinuclear region of cytoplasm	Rap GTPase activator activity			cervix(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(1)|urinary_tract(1)	10						GCCAAGCCATCAGTACCCAGT	0.617000													4	66					0	0	1	0	0
CNTN4	152330	broad.mit.edu	37	3	3030084	3030084	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr3:3030084G>A	ENST00000397461.1	+	13	1798	c.1414G>A	c.(1414-1416)Gct>Act	p.A472T	CNTN4_ENST00000475817.1_3'UTR|CNTN4_ENST00000427331.1_Missense_Mutation_p.A472T|CNTN4_ENST00000418658.1_Missense_Mutation_p.A472T|CNTN4_ENST00000397459.2_Missense_Mutation_p.A144T|CNTN4_ENST00000358480.3_Missense_Mutation_p.A253T|CNTN4_ENST00000448906.2_Missense_Mutation_p.A144T	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	472	Ig-like C2-type 5.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		TAAATCAGACGCTGGGAGTTA	0.363000													8	114					0	0	1	0	0
MAGI1	9223	broad.mit.edu	37	3	65422833	65422833	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr3:65422833G>A	ENST00000330909.8	-	10	1359	c.1360C>T	c.(1360-1362)Cag>Tag	p.Q454*	MAGI1_ENST00000483466.1_Nonsense_Mutation_p.Q454*|MAGI1_ENST00000470990.1_5'UTR|MAGI1_ENST00000497477.2_Nonsense_Mutation_p.Q454*|MAGI1_ENST00000402939.2_Nonsense_Mutation_p.Q454*	NM_015520.1	NP_056335.1	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 1	454					cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|liver(1)|lung(21)|pancreas(1)|skin(5)	51		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		ACTTTACCCTGAAGTGGAACT	0.403000													4	44					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	71008186	71008186	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr16:71008186C>G	ENST00000393567.2	-	33	5077	c.4927G>C	c.(4927-4929)Gat>Cat	p.D1643H		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	1643										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				TTTACACGATCTAGCTCAGTA	0.423000													4	12					0	0	1	0	0
ARL11	115761	broad.mit.edu	37	13	50204892	50204892	+	Silent	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr13:50204892C>T	ENST00000282026.1	+	2	644	c.309C>T	c.(307-309)ctC>ctT	p.L103L	ARL11_ENST00000490932.1_Intron	NM_138450.5	NP_612459.1	Q969Q4	ARL11_HUMAN	ADP-ribosylation factor-like 11	103					small GTPase mediated signal transduction	intracellular	GTP binding|protein binding			kidney(1)|large_intestine(4)|ovary(1)	6		Lung NSC(96;2.1e-05)|Breast(56;0.00015)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.119)|Kidney(9;0.169)	GBM - Glioblastoma multiforme(99;1.67e-09)		CGGCTGAGCTCACAGAAGTCC	0.572000													9	45					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	8995667	8995667	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr19:8995667G>C	ENST00000397910.4	-	63	41524	c.41321C>G	c.(41320-41322)tCt>tGt	p.S13774C	MUC16_ENST00000380951.5_Missense_Mutation_p.S415C	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13776				Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGGAGTCTTAGATGCTCCCAG	0.488000													3	20					0	0	1	0	0
PRPS1L1	221823	broad.mit.edu	37	7	18066917	18066917	+	Silent	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr7:18066917C>T	ENST00000506618.2	-	1	569	c.489G>A	c.(487-489)aaG>aaA	p.K163K		NM_175886.2	NP_787082	P21108	PRPS3_HUMAN	phosphoribosyl pyrophosphate synthetase 1-like 1	163					nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(3)	18	Lung NSC(10;0.0385)|all_lung(11;0.0736)					TAATGCAGTTCTTCCACTCAG	0.438000													18	55					0	0	1	0	0
ZNF91	7644	broad.mit.edu	37	19	23542761	23542761	+	Nonsense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr19:23542761G>C	ENST00000300619.7	-	4	3225	c.3020C>G	c.(3019-3021)tCa>tGa	p.S1007*	ZNF91_ENST00000599743.1_Intron|ZNF91_ENST00000397082.2_Nonsense_Mutation_p.S975*	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	1007						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding						all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				AGTTAGGGTTGAGGATTGGCT	0.383000													18	107					0	0	1	0	0
ACSS3	79611	broad.mit.edu	37	12	81536964	81536964	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr12:81536964C>T	ENST00000548058.1	+	5	1769	c.859C>T	c.(859-861)Cct>Tct	p.P287S	ACSS3_ENST00000261206.3_Missense_Mutation_p.P286S			Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	287						mitochondrion	acetate-CoA ligase activity|ATP binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(7)|liver(3)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	51						TGACTGTGTTCCTGTTCTTTC	0.448000													8	69					0	0	1	0	0
PNLIPRP1	5407	broad.mit.edu	37	10	118360682	118360682	+	Silent	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr10:118360682C>T	ENST00000528052.1	+	10	1103	c.1032C>T	c.(1030-1032)ttC>ttT	p.F344F	PNLIPRP1_ENST00000534537.1_Silent_p.F344F|PNLIPRP1_ENST00000358834.4_Silent_p.F344F			P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1	344					lipid metabolic process		calcium ion binding|triglyceride lipase activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	38				all cancers(201;0.0161)		AGAAATTCTTCTTGAACACAG	0.453000													11	73					0	0	1	0	0
H2AFY2	55506	broad.mit.edu	37	10	71855428	71855428	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr10:71855428G>A	ENST00000373255.4	+	6	871	c.607G>A	c.(607-609)Gac>Aac	p.D203N		NM_018649.2	NP_061119.1	Q9P0M6	H2AW_HUMAN	H2A histone family, member Y2	203	Macro.				chromatin modification|dosage compensation|nucleosome assembly	Barr body|nucleosome	DNA binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(4)|skin(1)	15						AACCCAGAGTGACATCAGCCA	0.408000													3	24					0	0	1	0	0
PMFBP1	83449	broad.mit.edu	37	16	72153916	72153916	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr16:72153916C>G	ENST00000537465.1	-	20	3014	c.2856G>C	c.(2854-2856)aaG>aaC	p.K952N	PMFBP1_ENST00000537792.1_Intron|PMFBP1_ENST00000237353.10_Missense_Mutation_p.K947N|PMFBP1_ENST00000355636.6_Missense_Mutation_p.K822N			Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	952										NS(1)|breast(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	45		Ovarian(137;0.179)				CGGCTTTCATCTTCTTCTCTT	0.542000													5	49					0	0	1	0	0
ECM2	1842	broad.mit.edu	37	9	95280061	95280061	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr9:95280061C>G	ENST00000344604.5	-	3	538	c.389G>C	c.(388-390)aGa>aCa	p.R130T	ECM2_ENST00000375540.1_Missense_Mutation_p.R130T|ECM2_ENST00000444490.2_Missense_Mutation_p.R130T|CENPP_ENST00000375587.3_Intron	NM_001197295.1|NM_001393.3	NP_001184224.1|NP_001384.1	O94769	ECM2_HUMAN	extracellular matrix protein 2, female organ and adipocyte specific	130	VWFC.				cell-matrix adhesion		integrin binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27						ACAAAGAACTCTTCCATCTGA	0.527000													26	61					0	0	1	0	0
DIDO1	11083	broad.mit.edu	37	20	61512603	61512603	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr20:61512603C>T	ENST00000266070.4	-	16	5030	c.4705G>A	c.(4705-4707)Gag>Aag	p.E1569K	DIDO1_ENST00000395343.1_Missense_Mutation_p.E1569K	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	1569					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					TCACCGGTCTCAGTGGCCAGG	0.711000													8	28					0	0	1	0	0
AMIGO2	347902	broad.mit.edu	37	12	47472393	47472393	+	Silent	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr12:47472393C>T	ENST00000266581.4	-	2	859	c.393G>A	c.(391-393)acG>acA	p.T131T	AMIGO2_ENST00000321382.3_Silent_p.T131T|AMIGO2_ENST00000550413.1_Silent_p.T131T|AMIGO2_ENST00000429635.1_Silent_p.T131T	NM_181847.4	NP_862830.1	Q86SJ2	AMGO2_HUMAN	adhesion molecule with Ig-like domain 2	131					heterophilic cell-cell adhesion|homophilic cell adhesion	integral to membrane|nucleus|plasma membrane				endometrium(2)|kidney(1)|large_intestine(8)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	Renal(347;0.138)|Lung SC(27;0.192)					CATTTTTCACCGTCTTCAGCT	0.418000													4	108					0	0	1	0	0
RAD21	5885	broad.mit.edu	37	8	117869588	117869588	+	Silent	SNP	C	C	G	rs139128240		TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr8:117869588C>G	ENST00000297338.2	-	6	893	c.606G>C	c.(604-606)ctG>ctC	p.L202L	RAD21_ENST00000523547.1_5'UTR	NM_006265.2	NP_006256.1	O60216	RAD21_HUMAN	RAD21 homolog (S. pombe)	202					apoptosis|cell division|chromosome segregation|double-strand break repair|mitotic metaphase/anaphase transition|mitotic prometaphase|protein localization to chromatin|reciprocal meiotic recombination|regulation of transcription from RNA polymerase II promoter	chromosome, centromeric region|cohesin complex|nuclear chromosome|nucleoplasm	protein binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|skin(1)|stomach(1)	32	all_cancers(13;1.21e-21)|Lung NSC(37;0.000134)|Ovarian(258;0.0172)					TTTTCTCATTCAGATTGCTGG	0.363000													26	69					0	0	1	0	0
CDH7	1005	broad.mit.edu	37	18	63547879	63547879	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr18:63547879G>C	ENST00000397968.2	+	12	2533	c.2107G>C	c.(2107-2109)Gat>Cat	p.D703H	CDH7_ENST00000323011.3_Missense_Mutation_p.D703H	NM_004361.2	NP_004352.2	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2	703					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(43)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	80		Esophageal squamous(42;0.129)				AAGCATCCCAGATAATGTCAT	0.443000													17	101					0	0	1	0	0
PRPSAP1	5635	broad.mit.edu	37	17	74307645	74307645	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr17:74307645C>T	ENST00000446526.3	-	10	1581	c.1136G>A	c.(1135-1137)cGa>cAa	p.R379Q	PRPSAP1_ENST00000588364.1_5'UTR|PRPSAP1_ENST00000324684.4_Missense_Mutation_p.R276Q	NM_002766.2	NP_002757.2	Q14558	KPRA_HUMAN	phosphoribosyl pyrophosphate synthetase-associated protein 1	350					nucleotide biosynthetic process		enzyme inhibitor activity|identical protein binding|magnesium ion binding|ribose phosphate diphosphokinase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	17						AGTGATGTTTCGGAAAAGGTA	0.468000													11	36					0	0	1	0	0
LRIT2	340745	broad.mit.edu	37	10	85981948	85981948	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr10:85981948C>T	ENST00000372113.4	-	3	1386	c.1381G>A	c.(1381-1383)Gag>Aag	p.E461K	LRIT2_ENST00000538192.1_Missense_Mutation_p.E471K	NM_001017924.2	NP_001017924.1	A6NDA9	LRIT2_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 2	461						integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|prostate(6)|urinary_tract(1)	32						AGGAGGTGCTCACGTGCCTCT	0.612000													6	41					0	0	1	0	0
PODXL2	50512	broad.mit.edu	37	3	127379611	127379611	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr3:127379611C>T	ENST00000342480.6	+	3	779	c.740C>T	c.(739-741)tCa>tTa	p.S247L		NM_015720.2	NP_056535.1	Q9NZ53	PDXL2_HUMAN	podocalyxin-like 2	247					leukocyte tethering or rolling	integral to plasma membrane	glycosaminoglycan binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	26						CTGCTGCCTTCAGTCACCCCA	0.637000													15	25					0	0	1	0	0
C16orf78	123970	broad.mit.edu	37	16	49433105	49433105	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr16:49433105G>C	ENST00000299191.3	+	5	831	c.714G>C	c.(712-714)atG>atC	p.M238I		NM_144602.2	NP_653203.1	Q8WTQ4	CP078_HUMAN	chromosome 16 open reading frame 78	238										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|upper_aerodigestive_tract(1)	22						ATGCAGGAATGAATGTGGATA	0.483000													13	51					0	0	1	0	0
ERBB2	2064	broad.mit.edu	37	17	37868208	37868208	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr17:37868208C>T	ENST00000406381.2	+	10	1349	c.839C>T	c.(838-840)tCc>tTc	p.S280F	ERBB2_ENST00000584601.1_Missense_Mutation_p.S280F|ERBB2_ENST00000578199.1_Missense_Mutation_p.S280F|ERBB2_ENST00000540147.1_Missense_Mutation_p.S280F|ERBB2_ENST00000269571.5_Missense_Mutation_p.S310F|ERBB2_ENST00000540042.1_Missense_Mutation_p.S280F|ERBB2_ENST00000541774.1_Missense_Mutation_p.S295F|ERBB2_ENST00000445658.2_Missense_Mutation_p.S34F|ERBB2_ENST00000584450.1_Missense_Mutation_p.S310F	NM_001005862.1	NP_001005862.1	P04626	ERBB2_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	310					cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.S310F(6)|p.S310Y(1)		NS(1)|breast(16)|central_nervous_system(17)|endometrium(6)|haematopoietic_and_lymphoid_tissue(8)|kidney(4)|large_intestine(16)|liver(3)|lung(125)|ovary(18)|pancreas(1)|prostate(4)|skin(1)|stomach(14)|upper_aerodigestive_tract(9)|urinary_tract(4)	247	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	GACGTGGGATCCTGCACCCTC	0.582000		1	"""A, Mis, O"""		"""breast, ovarian, other tumour types, NSCLC, gastric"""					TCGA GBM(5;<1E-08)			52	116					0	0	1	0	0
NOS3	4846	broad.mit.edu	37	7	150696314	150696314	+	Silent	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr7:150696314C>T	ENST00000297494.3	+	9	1350	c.993C>T	c.(991-993)taC>taT	p.Y331Y	NOS3_ENST00000461406.1_Silent_p.Y125Y|NOS3_ENST00000467517.1_Silent_p.Y331Y|NOS3_ENST00000484524.1_Silent_p.Y331Y	NM_000603.4	NP_000594.2	P29474	NOS3_HUMAN	nitric oxide synthase 3 (endothelial cell)	331	Interaction with NOSIP.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(3)|breast(3)|central_nervous_system(5)|endometrium(1)|kidney(4)|large_intestine(6)|liver(2)|lung(11)|ovary(3)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	50	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	TGCGCTGGTACGCCCTCCCGG	0.642000													21	56					0	0	1	0	0
CCDC91	55297	broad.mit.edu	37	12	28458687	28458687	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr12:28458687A>G	ENST00000545336.1	+	7	634	c.215A>G	c.(214-216)gAg>gGg	p.E72G	CCDC91_ENST00000381259.1_Missense_Mutation_p.E72G|CCDC91_ENST00000539107.1_Missense_Mutation_p.E72G|CCDC91_ENST00000540401.1_3'UTR|CCDC91_ENST00000306172.5_Missense_Mutation_p.E42G|CCDC91_ENST00000381256.1_Missense_Mutation_p.E72G			Q7Z6B0	CCD91_HUMAN	coiled-coil domain containing 91	72					protein transport	Golgi apparatus|membrane				NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)|skin(1)	22	Acute lymphoblastic leukemia(23;0.00718)|all_hematologic(23;0.0113)|Lung SC(9;0.184)					TCATCACCAGAGAATACACAT	0.393000													15	109					0	0	1	0	0
ZNF846	162993	broad.mit.edu	37	19	9869189	9869189	+	Silent	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr19:9869189C>T	ENST00000397902.2	-	6	977	c.564G>A	c.(562-564)caG>caA	p.Q188Q	ZNF846_ENST00000588267.1_Silent_p.Q59Q|ZNF846_ENST00000586293.1_3'UTR|ZNF846_ENST00000592859.1_Silent_p.Q59Q	NM_001077624.1	NP_001071092.1	Q147U1	ZN846_HUMAN	zinc finger protein 846	188					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	22						GAGTTTTATTCTGCCTAGTAA	0.353000													20	87					0	0	1	0	0
STK40	83931	broad.mit.edu	37	1	36820993	36820993	+	Silent	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr1:36820993C>G	ENST00000359297.2	-	4	391	c.384G>C	c.(382-384)cgG>cgC	p.R128R	STK40_ENST00000373132.3_Silent_p.R128R|STK40_ENST00000373130.3_Silent_p.R133R|STK40_ENST00000373129.3_Silent_p.R128R|STK40_ENST00000482458.1_5'UTR			Q8N2I9	STK40_HUMAN	serine/threonine kinase 40	128	Protein kinase.					cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)|stomach(1)	13		Myeloproliferative disorder(586;0.0393)				TCTTAACCATCCGGCTGGATT	0.577000													16	149					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8153019	8153019	+	Missense_Mutation	SNP	A	A	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr19:8153019A>T	ENST00000600128.1	-	52	6835	c.6421T>A	c.(6421-6423)Tgc>Agc	p.C2141S	FBN3_ENST00000601739.1_Missense_Mutation_p.C2141S|FBN3_ENST00000270509.2_Missense_Mutation_p.C2141S			Q75N90	FBN3_HUMAN	fibrillin 3	2141	EGF-like 34; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						ACATTGGTGCATGTCCCTTGC	0.607000													4	25					0	0	1	0	0
CHRM3	1131	broad.mit.edu	37	1	240071668	240071668	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr1:240071668G>A	ENST00000255380.4	+	5	1696	c.917G>A	c.(916-918)aGg>aAg	p.R306K		NM_000740.2	NP_000731.1	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	306					cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(4)|lung(19)|ovary(4)|prostate(1)|skin(12)|upper_aerodigestive_tract(1)	51	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	TCCAACAGGAGGAAGTATGGC	0.532000													4	20					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56485189	56485189	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr6:56485189C>A	ENST00000370765.6	-	23	3750	c.3643G>T	c.(3643-3645)Gag>Tag	p.E1215*	DST_ENST00000244364.6_Intron|DST_ENST00000446842.2_Intron|DST_ENST00000361203.3_Intron|DST_ENST00000421834.2_Intron|DST_ENST00000370788.2_Intron|DST_ENST00000370769.4_Intron|DST_ENST00000312431.6_Intron|DST_ENST00000370754.5_Intron	NM_001723.5	NP_001714.1	Q03001	DYST_HUMAN	dystonin	1556					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CTCACCCGCTCCAGTTCTCTT	0.502000													10	37					2.74318e-10	3.04021e-10	1	1	0
HMGCL	3155	broad.mit.edu	37	1	24144012	24144012	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr1:24144012G>C	ENST00000374483.4	-	4	802	c.131C>G	c.(130-132)tCt>tGt	p.S44C	HMGCL_ENST00000509389.1_5'UTR|HMGCL_ENST00000374490.3_Missense_Mutation_p.S69C|HMGCL_ENST00000436439.2_Missense_Mutation_p.S69C			P35914	HMGCL_HUMAN	3-hydroxymethyl-3-methylglutaryl-CoA lyase	69					acetoacetic acid biosynthetic process|ketone body biosynthetic process	mitochondrial matrix	hydroxymethylglutaryl-CoA lyase activity|metal ion binding	p.S69C(1)		central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	12		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.0044)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.38e-24)|Colorectal(126;5.58e-08)|COAD - Colon adenocarcinoma(152;3.12e-06)|GBM - Glioblastoma multiforme(114;4.9e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000982)|KIRC - Kidney renal clear cell carcinoma(1967;0.0034)|STAD - Stomach adenocarcinoma(196;0.0128)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0856)|LUSC - Lung squamous cell carcinoma(448;0.188)		TTCTATAACAGAGAGTCCTGC	0.443000													3	65					0	0	1	0	0
HAUS6	54801	broad.mit.edu	37	9	19078198	19078198	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr9:19078198G>C	ENST00000380502.3	-	10	1634	c.1167C>G	c.(1165-1167)ttC>ttG	p.F389L	HAUS6_ENST00000380496.1_Missense_Mutation_p.F253L	NM_001270890.1|NM_017645.4	NP_001257819.1|NP_060115.3	Q7Z4H7	HAUS6_HUMAN	HAUS augmin-like complex, subunit 6	389					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|nucleus|spindle				autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						TAATTAGACTGAAAGGAGACA	0.388000													4	41					0	0	1	0	0
ATR	545	broad.mit.edu	37	3	142185265	142185265	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr3:142185265C>T	ENST00000350721.4	-	40	6919	c.6798G>A	c.(6796-6798)atG>atA	p.M2266I	ATR_ENST00000383101.3_Missense_Mutation_p.M2202I|RP11-383G6.3_ENST00000460977.1_RNA	NM_001184.3	NP_001175.2	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related	2266					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			NS(1)|breast(10)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|liver(2)|lung(45)|ovary(3)|skin(10)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(4)	122						GTGTAGGTATCATGACTGATT	0.403000								Other conserved DNA damage response genes					6	50					0	0	1	0	0
TTLL12	23170	broad.mit.edu	37	22	43579092	43579092	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr22:43579092C>T	ENST00000216129.6	-	2	304	c.241G>A	c.(241-243)Gag>Aag	p.E81K		NM_015140.3	NP_055955.1	Q14166	TTL12_HUMAN	tubulin tyrosine ligase-like family, member 12	81					protein modification process		tubulin-tyrosine ligase activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)	13		Ovarian(80;0.221)|Glioma(61;0.222)				CGGGCTGCCTCGTCCTCCTCC	0.647000													9	69					0	0	1	0	0
BAD	572	broad.mit.edu	37	11	64037703	64037703	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr11:64037703C>A	ENST00000394532.3	-	3	755	c.485G>T	c.(484-486)gGa>gTa	p.G162V	BAD_ENST00000309032.3_Missense_Mutation_p.G162V|BAD_ENST00000544785.1_Silent_p.G98G	NM_004322.3	NP_004313.1	Q92934	BAD_HUMAN	BCL2-associated agonist of cell death	162					activation of pro-apoptotic gene products|ADP metabolic process|ATP metabolic process|cellular response to hypoxia|cellular response to mechanical stimulus|cellular response to nicotine|glucose homeostasis|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|pore complex assembly|positive regulation of epithelial cell proliferation|positive regulation of glucokinase activity|positive regulation of insulin secretion|positive regulation of mitochondrial membrane potential|positive regulation of type B pancreatic cell development|regulation of mitochondrial membrane permeability|type B pancreatic cell proliferation	cytosol|mitochondrial outer membrane	caspase activator activity|phospholipid binding|protein kinase binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(1)	4						GGCGGAGCTTCCCCTGCCCAA	0.632000													3	24					0.00024832	0.000258729	1	1	0
FKBP9	11328	broad.mit.edu	37	7	33014923	33014923	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr7:33014923C>G	ENST00000242209.4	+	3	666	c.497C>G	c.(496-498)tCt>tGt	p.S166C	FKBP9_ENST00000538336.1_Missense_Mutation_p.S219C|AVL9_ENST00000404479.1_Intron|FKBP9_ENST00000538443.1_Missense_Mutation_p.S28C	NM_001284343.1|NM_007270.3	NP_001271272.1|NP_009201.2	O95302	FKBP9_HUMAN	FK506 binding protein 9, 63 kDa	166	PPIase FKBP-type 2.				protein folding	endoplasmic reticulum|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			central_nervous_system(13)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)	39			GBM - Glioblastoma multiforme(11;0.0156)			ATCCAGGTGTCTGATTTTGTG	0.473000													7	53					0	0	1	0	0
ABCA2	20	broad.mit.edu	37	9	139909942	139909942	+	Silent	SNP	G	G	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr9:139909942G>T	ENST00000265662.5	-	24	3768	c.3621C>A	c.(3619-3621)ctC>ctA	p.L1207L	ABCA2_ENST00000341511.6_Silent_p.L1207L|ABCA2_ENST00000371605.3_Silent_p.L1206L			Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 2	1206	ABC transporter 1.				cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances	p.L1207L(1)		central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|liver(1)|lung(25)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	41	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		CCTTGAGGAAGAGCGGGGAGC	0.647000													4	3					0.150653	0.151963	1	1	0
COASY	80347	broad.mit.edu	37	17	40715322	40715322	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr17:40715322G>C	ENST00000393818.2	+	1	1138	c.682G>C	c.(682-684)Gac>Cac	p.D228H	COASY_ENST00000449624.1_5'UTR|COASY_ENST00000421097.2_Missense_Mutation_p.D228H|COASY_ENST00000590958.1_Missense_Mutation_p.D257H|COASY_ENST00000420359.1_Missense_Mutation_p.D228H	NM_025233.6	NP_079509.5	Q13057	COASY_HUMAN	CoA synthase	228	Phosphopantetheine adenylyltransferase.				coenzyme A biosynthetic process|pantothenate metabolic process	mitochondrial outer membrane	ATP binding|dephospho-CoA kinase activity|pantetheine-phosphate adenylyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)	21		all_cancers(22;1.06e-05)|Breast(137;0.000153)|all_epithelial(22;0.000344)		BRCA - Breast invasive adenocarcinoma(366;0.13)		GGGAGTAGCAGACAAAGATCT	0.592000													16	33					0	0	1	0	0
CCDC34	91057	broad.mit.edu	37	11	27379033	27379033	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr11:27379033C>T	ENST00000317945.6	-	2	454	c.415G>A	c.(415-417)Gaa>Aaa	p.E139K	CCDC34_ENST00000328697.6_Missense_Mutation_p.E139K	NM_080654.2	NP_542385.1	Q96HJ3	CCD34_HUMAN	coiled-coil domain containing 34	139										endometrium(2)|large_intestine(4)|lung(1)|prostate(1)|urinary_tract(1)	9						AGGCGGCTTTCTGGTAAGCGC	0.433000													10	99					0	0	1	0	0
UHRF1BP1	54887	broad.mit.edu	37	6	34791060	34791060	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr6:34791060G>A	ENST00000192788.5	+	4	444	c.273G>A	c.(271-273)atG>atA	p.M91I	UHRF1BP1_ENST00000452449.2_Missense_Mutation_p.M91I	NM_017754.3	NP_060224.3	Q6BDS2	URFB1_HUMAN	UHRF1 binding protein 1	91										breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(24)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	54						AGGTGGAGATGAAGACATGTG	0.453000													9	118					0	0	1	0	0
DPYS	1807	broad.mit.edu	37	8	105436506	105436506	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr8:105436506C>T	ENST00000351513.2	-	7	1336	c.1204G>A	c.(1204-1206)Gac>Aac	p.D402N		NM_001385.2	NP_001376.1	Q14117	DPYS_HUMAN	dihydropyrimidinase	402					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			ATAACAATGTCAGCATCTGAT	0.378000													18	99					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52386706	52386706	+	Missense_Mutation	SNP	A	A	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr3:52386706A>C	ENST00000420323.2	+	18	3271	c.3010A>C	c.(3010-3012)Agc>Cgc	p.S1004R		NM_015512.4	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	1004	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GCGCATCTTCAGCTTGCCCAT	0.617000													3	10					0	0	1	0	0
ABCA2	20	broad.mit.edu	37	9	139909936	139909936	+	Silent	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr9:139909936G>A	ENST00000265662.5	-	24	3774	c.3627C>T	c.(3625-3627)ctC>ctT	p.L1209L	ABCA2_ENST00000341511.6_Silent_p.L1209L|ABCA2_ENST00000371605.3_Silent_p.L1208L			Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 2	1208	ABC transporter 1.				cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|liver(1)|lung(25)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	41	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		AGGTGCCCTTGAGGAAGAGCG	0.647000													4	3					0	0	1	0	0
SLC25A46	91137	broad.mit.edu	37	5	110097168	110097168	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr5:110097168C>T	ENST00000355943.3	+	8	1069	c.943C>T	c.(943-945)Cca>Tca	p.P315S	SLC25A46_ENST00000513807.1_Missense_Mutation_p.P153S|SLC25A46_ENST00000509442.2_Missense_Mutation_p.P224S|SLC25A46_ENST00000447245.2_Missense_Mutation_p.P234S|SLC25A46_ENST00000513706.1_3'UTR|SLC25A46_ENST00000509432.1_Missense_Mutation_p.P102S|SLC25A46_ENST00000504098.1_Missense_Mutation_p.P169S	NM_138773.1	NP_620128.1	Q96AG3	S2546_HUMAN	solute carrier family 25, member 46	315					transport	integral to membrane|mitochondrial inner membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|skin(1)	10		all_cancers(142;0.00203)|all_epithelial(76;4.52e-05)|Prostate(80;0.0115)|Colorectal(57;0.0676)|Ovarian(225;0.156)		OV - Ovarian serous cystadenocarcinoma(64;2.58e-09)|Epithelial(69;7.29e-08)|all cancers(49;9.35e-06)|COAD - Colon adenocarcinoma(37;0.211)		TGCTTATTTTCCAGAACTTAT	0.413000													21	152					0	0	1	0	0
NINL	22981	broad.mit.edu	37	20	25459711	25459711	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr20:25459711G>T	ENST00000278886.6	-	16	2122	c.2049C>A	c.(2047-2049)caC>caA	p.H683Q	NINL_ENST00000422516.1_Missense_Mutation_p.H683Q	NM_025176.4	NP_079452.3	Q9Y2I6	NINL_HUMAN	ninein-like	683					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(13)|lung(25)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	57						GAGACTTCTCGTGGAGCTCCT	0.647000													9	50					3.09899e-07	3.35965e-07	1	1	0
PAX1	5075	broad.mit.edu	37	20	21687300	21687300	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr20:21687300C>T	ENST00000398485.2	+	2	565	c.511C>T	c.(511-513)Cgc>Tgc	p.R171C	PAX1_ENST00000460221.1_Intron|PAX1_ENST00000444366.2_Missense_Mutation_p.R147C	NM_001257096.1|NM_006192.4	NP_001244025.1|NP_006183.2	P15863	PAX1_HUMAN	paired box 1	171	Paired.				regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(21)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	38						GAGCAAGCCCCGCGTCACCAC	0.667000													6	43					0	0	1	0	0
ZNF254	9534	broad.mit.edu	37	19	24309664	24309664	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr19:24309664C>T	ENST00000357002.4	+	4	977	c.862C>T	c.(862-864)Cat>Tat	p.H288Y	ZNF254_ENST00000342944.6_Missense_Mutation_p.H203Y	NM_001278661.1|NM_001278662.1|NM_001278664.1|NM_001278677.1|NM_001278678.1|NM_203282.2	NP_001265590.1|NP_001265591.1|NP_001265593.1|NP_001265606.1|NP_001265607.1|NP_975011.3	O75437	ZN254_HUMAN	zinc finger protein 254	288					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				TAAGATAATTCATACTGGAGA	0.353000													6	56					0	0	1	0	0
IGHV7-81	28378	broad.mit.edu	37	14	107282933	107282933	+	RNA	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr14:107282933G>C	ENST00000390639.2	-	0	263																											TGTAGGTGTTGAACCATCCCA	0.537000													8	81					0	0	1	0	0
SIGLEC10	89790	broad.mit.edu	37	19	51920086	51920086	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr19:51920086C>T	ENST00000353836.5	-	3	761	c.540G>A	c.(538-540)tgG>tgA	p.W180*	SIGLEC10_ENST00000436984.2_Intron|SIGLEC10_ENST00000339313.5_Nonsense_Mutation_p.W180*|SIGLEC10_ENST00000441969.3_Intron|CTD-2616J11.2_ENST00000532688.1_RNA|SIGLEC10_ENST00000356298.5_Nonsense_Mutation_p.W180*|SIGLEC10_ENST00000442846.3_Intron|SIGLEC10_ENST00000439889.2_Intron|SIGLEC10_ENST00000525998.1_Nonsense_Mutation_p.W180*|SIGLEC10_ENST00000432469.2_Intron	NM_001171157.1|NM_001171158.1|NM_001171159.1	NP_001164628.1|NP_001164629.1|NP_001164630.1	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10	180	Ig-like C2-type 1.				cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(27)|ovary(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		CAGCCCCCGTCCAGGAGAAAG	0.602000													6	33					0	0	1	0	0
OC90	729330	broad.mit.edu	37	8	133048645	133048645	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr8:133048645C>G	ENST00000262283.5	-	13	1387	c.1288G>C	c.(1288-1290)Gac>Cac	p.D430H	OC90_ENST00000443356.2_Missense_Mutation_p.D234H|OC90_ENST00000254627.3_Intron|OC90_ENST00000603859.1_Intron			Q02509	OC90_HUMAN	otoconin 90	234	Phospholipase A2-like 3.				lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(23)|ovary(2)|prostate(1)|skin(1)	37	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			ATCAGTCTGTCAGCCTCAGTC	0.443000													9	65					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168102265	168102265	+	Silent	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr2:168102265C>T	ENST00000409195.1	+	9	4452	c.4363C>T	c.(4363-4365)Cta>Tta	p.L1455L	XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000295237.9_Silent_p.L1455L|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409273.1_Silent_p.L1233L|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409043.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1280					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						ATCTACTTGGCTATTTGAAAC	0.338000													7	57					0	0	1	0	0
AHDC1	27245	broad.mit.edu	37	1	27875893	27875893	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr1:27875893G>A	ENST00000374011.2	-	6	3702	c.2734C>T	c.(2734-2736)Cag>Tag	p.Q912*	AHDC1_ENST00000247087.5_Nonsense_Mutation_p.Q912*	NM_001029882.2	NP_001025053.1	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	912							DNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	42		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		AGGACAGGCTGAAAGGAGGGG	0.701000													5	26					0	0	1	0	0
ATP8B4	79895	broad.mit.edu	37	15	50152651	50152651	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr15:50152651G>C	ENST00000284509.6	-	28	3460	c.3319C>G	c.(3319-3321)Caa>Gaa	p.Q1107E	ATP8B4_ENST00000559829.1_Missense_Mutation_p.Q1107E	NM_024837.2	NP_079113.2	Q8TF62	AT8B4_HUMAN	ATPase, class I, type 8B, member 4	1107					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|urinary_tract(1)	73		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		GCCTTCTTTTGAGCCTTCTGC	0.522000													11	68					0	0	1	0	0
TAF4B	6875	broad.mit.edu	37	18	23873398	23873398	+	Silent	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr18:23873398C>T	ENST00000269142.5	+	9	2733	c.1735C>T	c.(1735-1737)Cta>Tta	p.L579L	TAF4B_ENST00000400466.2_Silent_p.L579L|TAF4B_ENST00000578121.1_Silent_p.L584L	NM_005640.1	NP_005631.1	Q92750	TAF4B_HUMAN	TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa	579					transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleolus|transcription factor TFIID complex	DNA binding|NF-kappaB binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(13)|prostate(1)|skin(1)	29	all_cancers(21;0.00151)|Lung NSC(5;0.000401)|all_lung(6;0.00115)|Ovarian(20;0.124)		Epithelial(2;9.57e-07)|all cancers(3;5.15e-06)|OV - Ovarian serous cystadenocarcinoma(3;1.96e-05)|LUSC - Lung squamous cell carcinoma(2;0.00594)|Lung(2;0.0267)			AGCTTCCATTCTAAAGCAAAT	0.308000													10	58					0	0	1	0	0
AACS	65985	broad.mit.edu	37	12	125591757	125591757	+	Silent	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr12:125591757C>T	ENST00000316519.6	+	8	1064	c.858C>T	c.(856-858)ttC>ttT	p.F286F	AACS_ENST00000316543.10_5'UTR|AACS_ENST00000261686.6_Silent_p.F286F	NM_023928.3	NP_076417.2	Q86V21	AACS_HUMAN	acetoacetyl-CoA synthetase	286					fatty acid metabolic process	cytosol	acetoacetate-CoA ligase activity|ATP binding			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(4)|liver(1)|lung(16)|ovary(1)|stomach(1)	26	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;9.82e-05)|Epithelial(86;0.000642)|all cancers(50;0.00843)		ACCCACTGTTCATCATGTTCT	0.617000													6	57					0	0	1	0	0
EPX	8288	broad.mit.edu	37	17	56276514	56276514	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr17:56276514G>A	ENST00000225371.5	+	8	1344	c.1234G>A	c.(1234-1236)Gac>Aac	p.D412N		NM_000502.4	NP_000493.1	P11678	PERE_HUMAN	eosinophil peroxidase	412					hydrogen peroxide catabolic process		heme binding|peroxidase activity|protein binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(9)|liver(2)|lung(20)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	48						GTGGAATGGAGACAAACTGTA	0.572000													13	20					0	0	1	0	0
ARL5B	221079	broad.mit.edu	37	10	18962939	18962939	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr10:18962939C>G	ENST00000377275.3	+	5	599	c.366C>G	c.(364-366)atC>atG	p.I122M		NM_178815.3	NP_848930.1	Q96KC2	ARL5B_HUMAN	ADP-ribosylation factor-like 5B	122					small GTPase mediated signal transduction	intracellular	GTP binding			lung(1)|ovary(1)	2						CAGTCCTTATCTTTGCAAATA	0.358000													7	38					0	0	1	0	0
MTMR3	8897	broad.mit.edu	37	22	30387504	30387504	+	Nonsense_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr22:30387504C>G	ENST00000333027.3	+	7	633	c.305C>G	c.(304-306)tCa>tGa	p.S102*	MTMR3_ENST00000351488.3_Nonsense_Mutation_p.S102*|MTMR3_ENST00000401950.2_Nonsense_Mutation_p.S102*|MTMR3_ENST00000323630.5_5'UTR|MTMR3_ENST00000415511.1_3'UTR|MTMR3_ENST00000406629.1_Nonsense_Mutation_p.S102*	NM_153050.2|NM_153051.2	NP_694690.1|NP_694691.1	Q13615	MTMR3_HUMAN	myotubularin related protein 3	102					phosphatidylinositol dephosphorylation	cytoplasm|membrane|membrane fraction|nucleus	metal ion binding|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(3)|large_intestine(3)|ovary(2)|skin(8)|upper_aerodigestive_tract(1)	17			OV - Ovarian serous cystadenocarcinoma(5;0.00204)|Epithelial(10;0.06)|all cancers(5;0.107)			TGTCAGTTTTCAACCTTTGAG	0.403000													9	44					0	0	1	0	0
DNM1P46	196968	broad.mit.edu	37	15	100331081	100331081	+	RNA	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr15:100331081C>T	ENST00000341853.1	-	0	3110					NR_003260.1																						CCCCTCCCCTCAGAGTAGGCG	0.517000													4	43					0	0	1	0	0
FAF1	11124	broad.mit.edu	37	1	51253723	51253723	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr1:51253723C>G	ENST00000396153.2	-	4	767	c.316G>C	c.(316-318)Gaa>Caa	p.E106Q	FAF1_ENST00000371778.4_Missense_Mutation_p.E106Q	NM_007051.2	NP_008982.1	Q9UNN5	FAF1_HUMAN	Fas (TNFRSF6) associated factor 1	106					apoptosis|cytoplasmic sequestering of NF-kappaB|positive regulation of apoptosis|positive regulation of protein complex assembly|proteasomal ubiquitin-dependent protein catabolic process|regulation of protein catabolic process	CD95 death-inducing signaling complex|cytosol|perinuclear region of cytoplasm	heat shock protein binding|NF-kappaB binding|protein kinase binding|protein kinase regulator activity	p.0?(3)		breast(2)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|pancreas(2)|upper_aerodigestive_tract(1)	24				GBM - Glioblastoma multiforme(3;3.18e-11)|all cancers(3;0.00526)		TCTCTGTATTCAACCCTGAAG	0.428000													9	25					0	0	1	0	0
TBC1D1	23216	broad.mit.edu	37	4	38091734	38091734	+	Silent	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr4:38091734C>G	ENST00000261439.4	+	13	2587	c.2232C>G	c.(2230-2232)ctC>ctG	p.L744L	TBC1D1_ENST00000508802.1_Silent_p.L838L	NM_001253914.1|NM_001253915.1|NM_015173.3	NP_001240843.1|NP_001240844.1|NP_055988.2	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	744						nucleus	Rab GTPase activator activity			NS(1)|breast(3)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	36						ATCAGAAGCTCCAAGGTTGGT	0.423000													8	47					0	0	1	0	0
SLC4A2	6522	broad.mit.edu	37	7	150772567	150772567	+	Silent	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr7:150772567G>A	ENST00000485713.1	+	20	4313	c.3273G>A	c.(3271-3273)gtG>gtA	p.V1091V	SLC4A2_ENST00000413384.2_Silent_p.V1091V|SLC4A2_ENST00000392826.2_Silent_p.V1082V|SLC4A2_ENST00000461735.1_Silent_p.V1077V|SLC4A2_ENST00000310317.5_Silent_p.V1009V|RP11-148K1.12_ENST00000485974.1_RNA	NM_001199692.1	NP_001186621.1	P04920	B3A2_HUMAN	solute carrier family 4 (anion exchanger), member 2	1091	Membrane (anion exchange).				bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity			NS(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(14)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	33			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGCAGCGGGTGACGGGGCTGC	0.637000													10	45					0	0	1	0	0
SPESP1	246777	broad.mit.edu	37	15	69238625	69238625	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr15:69238625G>C	ENST00000310673.3	+	2	906	c.752G>C	c.(751-753)aGa>aCa	p.R251T	RP11-809H16.2_ENST00000557966.1_RNA|NOX5_ENST00000455873.3_Intron|NOX5_ENST00000260364.5_Intron|NOX5_ENST00000448182.3_Intron	NM_145658.3	NP_663633.1	Q6UW49	SPESP_HUMAN	sperm equatorial segment protein 1	251					multicellular organismal development	acrosomal vesicle				breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(11)|prostate(1)|skin(1)|urinary_tract(1)	19						CCAGCATATAGAGAAGATATT	0.363000													11	72					0	0	1	0	0
FAM127B	26071	broad.mit.edu	37	X	134185862	134185862	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chrX:134185862C>T	ENST00000370775.2	-	1	343	c.277G>A	c.(277-279)Gat>Aat	p.D93N	FAM127B_ENST00000520964.1_Intron	NM_001078172.1	NP_001071640.1	Q9BWD3	F127B_HUMAN	family with sequence similarity 127, member B	93										breast(3)|endometrium(2)|large_intestine(3)|lung(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14	Acute lymphoblastic leukemia(192;0.000127)					CCCCGGTAATCATTGAGCAGG	0.642000													7	13					0	0	1	0	0
SMCHD1	23347	broad.mit.edu	37	18	2739443	2739443	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr18:2739443G>A	ENST00000320876.6	+	27	3777	c.3439G>A	c.(3439-3441)Gaa>Aaa	p.E1147K	RP11-703M24.5_ENST00000583546.1_RNA|SMCHD1_ENST00000261598.8_Missense_Mutation_p.E1147K	NM_015295.2	NP_056110.2	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible hinge domain containing 1	1147					chromosome organization		ATP binding			NS(3)|breast(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(16)|lung(15)|pancreas(1)	45						ACTTCCTGATGAACCTAAACA	0.343000													5	32					0	0	1	0	0
CLIP1	6249	broad.mit.edu	37	12	122837305	122837305	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr12:122837305C>G	ENST00000358808.2	-	8	1490	c.1336G>C	c.(1336-1338)Gaa>Caa	p.E446Q	CLIP1_ENST00000540338.1_Missense_Mutation_p.E446Q|CLIP1_ENST00000545889.1_Missense_Mutation_p.E147Q|CLIP1_ENST00000537178.1_Missense_Mutation_p.E446Q|CLIP1_ENST00000302528.7_Missense_Mutation_p.E446Q|CLIP1_ENST00000361654.4_Missense_Mutation_p.E446Q	NM_001247997.1|NM_002956.2	NP_001234926.1|NP_002947.1	P30622	CLIP1_HUMAN	CAP-GLY domain containing linker protein 1	446					mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			NS(1)|breast(5)|endometrium(4)|kidney(5)|large_intestine(16)|liver(1)|lung(21)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		GATTCTTCTTCAACCCGGAAC	0.393000													19	51					0	0	1	0	0
PNO1	56902	broad.mit.edu	37	2	68389445	68389445	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr2:68389445G>C	ENST00000263657.2	+	4	581	c.490G>C	c.(490-492)Gaa>Caa	p.E164Q	RP11-474G23.1_ENST00000406334.3_Intron	NM_020143.2	NP_064528.1	Q9NRX1	PNO1_HUMAN	partner of NOB1 homolog (S. cerevisiae)	164						nucleolus	RNA binding			endometrium(1)|large_intestine(1)|lung(2)	4						AGAGTCTTTTGAAATTACAGA	0.423000													9	65					0	0	1	0	0
GPR179	440435	broad.mit.edu	37	17	36489229	36489229	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr17:36489229C>T	ENST00000342292.4	-	10	1962	c.1942G>A	c.(1942-1944)Gag>Aag	p.E648K		NM_001004334.2	NP_001004334.2	Q6PRD1	GP179_HUMAN	G protein-coupled receptor 179	648						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(4)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(16)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				AGCTCGTCCTCACACACCTCA	0.617000													4	15					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102486368	102486368	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr14:102486368G>A	ENST00000360184.4	+	42	8646	c.8482G>A	c.(8482-8484)Gaa>Aaa	p.E2828K		NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	2828					cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						TTGGGCACATGAAGCTCTGCG	0.542000													4	32					0	0	1	0	0
ARHGAP9	64333	broad.mit.edu	37	12	57869669	57869669	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr12:57869669C>G	ENST00000393797.2	-	13	1663	c.1471G>C	c.(1471-1473)Gag>Cag	p.E491Q	ARHGAP9_ENST00000356411.2_Missense_Mutation_p.E420Q|ARHGAP9_ENST00000430041.2_Missense_Mutation_p.E236Q|ARHGAP9_ENST00000424809.2_Missense_Mutation_p.E420Q|ARHGAP9_ENST00000393791.3_Missense_Mutation_p.E420Q|ARHGAP9_ENST00000550288.1_Missense_Mutation_p.E499Q			Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9	420					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			endometrium(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(1)	30			GBM - Glioblastoma multiforme(3;3.37e-34)			AGCTCTGTCTCGTGGTCCGAC	0.657000													5	14					0	0	1	0	0
RBL2	5934	broad.mit.edu	37	16	53514499	53514499	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr16:53514499G>T	ENST00000262133.6	+	20	3039	c.2902G>T	c.(2902-2904)Gtt>Ttt	p.V968F	RBL2_ENST00000544545.1_Intron|RBL2_ENST00000379935.4_3'UTR	NM_005611.3	NP_005602.3	Q08999	RBL2_HUMAN	retinoblastoma-like 2 (p130)	968	Domain B.|Pocket; binds E1A.				cell cycle|chromatin modification|regulation of cell cycle|regulation of lipid kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(17)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45						CTCCAGTCCAGTTATGAGGTC	0.493000													15	49					2.23348e-06	2.39893e-06	1	1	0
MAST2	23139	broad.mit.edu	37	1	46498376	46498376	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr1:46498376G>C	ENST00000361297.2	+	26	3806	c.3523G>C	c.(3523-3525)Gag>Cag	p.E1175Q	MAST2_ENST00000372009.2_Missense_Mutation_p.E1082Q	NM_015112.2	NP_055927.2	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase 2	1175	PDZ.				regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			breast(1)|lung(3)|ovary(5)|stomach(2)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					GGAGGTGGTAGAGCTGATCCT	0.592000													8	43					0	0	1	0	0
SP7	121340	broad.mit.edu	37	12	53722332	53722332	+	Silent	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr12:53722332G>A	ENST00000536324.2	-	3	1177	c.894C>T	c.(892-894)atC>atT	p.I298I	SP7_ENST00000303846.3_Silent_p.I298I|SP7_ENST00000537210.2_Silent_p.I280I	NM_001173467.1	NP_001166938.1	Q8TDD2	SP7_HUMAN	Sp7 transcription factor	298					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(2)|large_intestine(3)|lung(7)|skin(1)|urinary_tract(1)	14						CGCAGCCAGGGATGTGGCAGC	0.652000													5	19					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8153018	8153018	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr19:8153018C>A	ENST00000600128.1	-	52	6836	c.6422G>T	c.(6421-6423)tGc>tTc	p.C2141F	FBN3_ENST00000601739.1_Missense_Mutation_p.C2141F|FBN3_ENST00000270509.2_Missense_Mutation_p.C2141F			Q75N90	FBN3_HUMAN	fibrillin 3	2141	EGF-like 34; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						GACATTGGTGCATGTCCCTTG	0.607000													4	25					1	1	1	1	0
MYO5C	55930	broad.mit.edu	37	15	52539115	52539115	+	Splice_Site	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr15:52539115C>T	ENST00000261839.7	-	16	2139	c.1978G>A	c.(1978-1980)Gaa>Aaa	p.E660K	MYO5C_ENST00000443683.2_3'UTR	NM_018728.3	NP_061198.2	Q9NQX4	MYO5C_HUMAN	myosin VC	660	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(7)|large_intestine(15)|lung(12)|ovary(7)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66				all cancers(107;0.0137)		AACACTTACTCAAAGGGTAAC	0.468000													5	41					0	0	1	0	0
HTT	3064	broad.mit.edu	37	4	3208298	3208298	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr4:3208298C>T	ENST00000355072.5	+	43	5939	c.5794C>T	c.(5794-5796)Cac>Tac	p.H1932Y		NM_002111.6	NP_002102	P42858	HD_HUMAN	huntingtin	1932					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		CAGCCTTTCCCACGAGCCTCC	0.473000													7	66					0	0	1	0	0
TLL1	7092	broad.mit.edu	37	4	166924645	166924645	+	Silent	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr4:166924645G>A	ENST00000061240.2	+	6	1382	c.735G>A	c.(733-735)gtG>gtA	p.V245V	TLL1_ENST00000507499.1_Silent_p.V245V|TLL1_ENST00000513213.1_Silent_p.V245V	NM_012464.4	NP_036596.3	O43897	TLL1_HUMAN	tolloid-like 1	245	Metalloprotease (By similarity).				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(21)|lung(26)|ovary(2)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		TGGGTCATGTGATAGGCTTTT	0.453000													7	74					0	0	1	0	0
TUBGCP5	114791	broad.mit.edu	37	15	22861907	22861907	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr15:22861907G>C	ENST00000283645.4	+	14	2057	c.1927G>C	c.(1927-1929)Gat>Cat	p.D643H	TUBGCP5_ENST00000453949.2_Missense_Mutation_p.D643H|TUBGCP5_ENST00000559846.1_3'UTR	NM_052903.4	NP_443135.3	Q96RT8	GCP5_HUMAN	tubulin, gamma complex associated protein 5	643					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(5)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(23)|prostate(1)|skin(2)|urinary_tract(1)	46		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.86e-06)|Epithelial(43;2.63e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000949)		TGATGTTCATGATCCACTGCT	0.423000													9	97					0	0	1	0	0
ZNF479	90827	broad.mit.edu	37	7	57187801	57187801	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr7:57187801C>T	ENST00000331162.4	-	5	1591	c.1321G>A	c.(1321-1323)Gaa>Aaa	p.E441K		NM_033273.1	NP_150376.1	Q96JC4	ZN479_HUMAN	zinc finger protein 479	441					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(53)|ovary(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	84			GBM - Glioblastoma multiforme(1;9.18e-12)			TTGCCACATTCTTCACATTTG	0.443000													19	102					0	0	1	0	0
LMOD3	56203	broad.mit.edu	37	3	69168494	69168494	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr3:69168494C>T	ENST00000420581.2	-	2	1191	c.1012G>A	c.(1012-1014)Gag>Aag	p.E338K	LMOD3_ENST00000489031.1_Missense_Mutation_p.E338K|LMOD3_ENST00000475434.1_Missense_Mutation_p.E338K	NM_198271.3	NP_938012.2	Q0VAK6	LMOD3_HUMAN	leiomodin 3 (fetal)	338						cytoplasm|cytoskeleton	tropomyosin binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(1)	13		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;7.88e-05)|Epithelial(33;0.000839)|LUSC - Lung squamous cell carcinoma(21;0.0119)|Lung(16;0.0191)|KIRC - Kidney renal clear cell carcinoma(39;0.205)|Kidney(39;0.24)		GTTAGCGTCTCATTAAACTGG	0.453000													23	202					0	0	1	0	0
NTAN1	123803	broad.mit.edu	37	16	15141340	15141340	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr16:15141340C>A	ENST00000287706.3	-	4	410	c.318G>T	c.(316-318)atG>atT	p.M106I	PDXDC1_ENST00000535621.2_Intron	NM_001270766.1|NM_173474.3	NP_001257695.1|NP_775745.1	Q96AB6	NTAN1_HUMAN	N-terminal asparagine amidase	106						cytoplasm				endometrium(1)|large_intestine(4)|lung(3)	8						TTATGGAGTTCATGATCAAGG	0.478000													12	52					1.5842e-08	1.73912e-08	1	1	0
SORT1	6272	broad.mit.edu	37	1	109867591	109867591	+	Silent	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr1:109867591G>A	ENST00000256637.6	-	14	1822	c.1764C>T	c.(1762-1764)ttC>ttT	p.F588F	SORT1_ENST00000538502.1_Silent_p.F451F	NM_002959.5	NP_002950.3	Q99523	SORT_HUMAN	sortilin 1	588					endocytosis|endosome to lysosome transport|endosome transport via multivesicular body sorting pathway|glucose import|Golgi to endosome transport|induction of apoptosis by extracellular signals|myotube differentiation|negative regulation of apoptosis|negative regulation of lipoprotein lipase activity|neuropeptide signaling pathway|ossification|plasma membrane to endosome transport|regulation of gene expression|response to insulin stimulus|vesicle organization	cell surface|coated pit|early endosome|endoplasmic reticulum membrane|endosome membrane|Golgi cisterna membrane|integral to membrane|lysosomal membrane|microsome|nuclear membrane|perinuclear region of cytoplasm|plasma membrane	enzyme binding|nerve growth factor binding|nerve growth factor receptor activity|neurotensin receptor activity, non-G-protein coupled			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(5)|ovary(2)|prostate(1)|skin(1)	26		all_epithelial(167;4.69e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0529)|Colorectal(144;0.142)|Epithelial(280;0.145)|Kidney(133;0.169)|all cancers(265;0.184)		AAGATTCTGTGAAGCCCCAAA	0.468000													7	76					0	0	1	0	0
KARS	3735	broad.mit.edu	37	16	75675477	75675477	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr16:75675477C>G	ENST00000319410.5	-	3	412	c.291G>C	c.(289-291)gaG>gaC	p.E97D	KARS_ENST00000302445.3_Missense_Mutation_p.E69D|KARS_ENST00000568378.1_Intron	NM_001130089.1	NP_001123561.1	Q15046	SYK_HUMAN	lysyl-tRNA synthetase	69					interspecies interaction between organisms|lysyl-tRNA aminoacylation|tRNA processing	cytosol|extracellular region|mitochondrial matrix|nucleus|plasma membrane|soluble fraction	ATP binding|lysine-tRNA ligase activity|metal ion binding|tRNA binding			kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	18					L-Lysine(DB00123)	GGTCCACGCTCTCTTCCTCAG	0.542000													8	33					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24884780	24884780	+	Silent	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr14:24884780C>T	ENST00000382554.3	+	9	4143	c.3825C>T	c.(3823-3825)ctC>ctT	p.L1275L		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	1275					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						TGGCCCTCCTCCAGGGCCTGC	0.632000													9	50					0	0	1	0	0
PRKRIR	5612	broad.mit.edu	37	11	76062190	76062190	+	Silent	SNP	C	C	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr11:76062190C>A	ENST00000260045.3	-	5	2109	c.2004G>T	c.(2002-2004)ctG>ctT	p.L668L		NM_004705.2	NP_004696.2	O43422	P52K_HUMAN	protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)	668					negative regulation of cell proliferation|response to stress|signal transduction		DNA binding|metal ion binding|protein dimerization activity			cervix(1)|endometrium(3)|large_intestine(4)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	25						TGATGTCAGGCAGGTGGAGGG	0.453000													12	72					2.68362e-12	2.9837e-12	1	1	0
LRRC15	131578	broad.mit.edu	37	3	194080555	194080555	+	Silent	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr3:194080555G>A	ENST00000347624.3	-	2	1303	c.1218C>T	c.(1216-1218)ctC>ctT	p.L406L	LRRC15_ENST00000428839.1_Silent_p.L412L|LRRC15_ENST00000439944.2_Silent_p.L412L	NM_130830.4	NP_570843.2	Q8TF66	LRC15_HUMAN	leucine rich repeat containing 15	406						integral to membrane				biliary_tract(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(20)|ovary(4)|prostate(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.94e-05)		CGAAGATGCCGAGGGGCAAGT	0.572000													3	15					0	0	1	0	0
PACSIN1	29993	broad.mit.edu	37	6	34498278	34498278	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr6:34498278G>C	ENST00000538621.1	+	8	1196	c.951G>C	c.(949-951)gaG>gaC	p.E317D	PACSIN1_ENST00000244458.2_Missense_Mutation_p.E317D|PACSIN1_ENST00000374043.2_Missense_Mutation_p.E275D	NM_001199583.2	NP_001186512.1	Q9BY11	PACN1_HUMAN	protein kinase C and casein kinase substrate in neurons 1	317					endocytosis		protein kinase activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|prostate(2)	13						CCAAGAAGGAGAAACAGCCTA	0.632000													3	19					0	0	1	0	0
TM9SF4	9777	broad.mit.edu	37	20	30737508	30737508	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr20:30737508G>C	ENST00000217315.5	+	10	1315	c.975G>C	c.(973-975)atG>atC	p.M325I	TM9SF4_ENST00000398022.2_Missense_Mutation_p.M342I			Q92544	TM9S4_HUMAN	transmembrane 9 superfamily protein member 4	342						integral to membrane				central_nervous_system(2)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			AGTACCCCATGATCCTCAGCT	0.622000													6	31					0	0	1	0	0
KIAA0922	23240	broad.mit.edu	37	4	154502710	154502710	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr4:154502710C>T	ENST00000409959.3	+	9	939	c.890C>T	c.(889-891)tCa>tTa	p.S297L	KIAA0922_ENST00000440693.1_Missense_Mutation_p.S297L|KIAA0922_ENST00000409663.3_Missense_Mutation_p.S297L	NM_001131007.1	NP_001124479.1	A2VDJ0	T131L_HUMAN	KIAA0922	297						integral to membrane				breast(2)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(16)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	63	all_hematologic(180;0.093)	Renal(120;0.118)				TCTGAGACCTCAGGTAAGGTG	0.308000													4	23					0	0	1	0	0
TNNT2	7139	broad.mit.edu	37	1	201334403	201334403	+	Silent	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr1:201334403C>G	ENST00000509001.1	-	9	583	c.297G>C	c.(295-297)ctG>ctC	p.L99L	TNNT2_ENST00000367317.4_Silent_p.L99L|TNNT2_ENST00000367320.2_Intron|TNNT2_ENST00000367318.5_Silent_p.L99L|TNNT2_ENST00000367315.2_Silent_p.L99L|TNNT2_ENST00000236918.7_Silent_p.L104L|TNNT2_ENST00000367322.1_Silent_p.L99L|TNNT2_ENST00000421663.2_Silent_p.L101L|TNNT2_ENST00000360372.4_Silent_p.L94L|TNNT2_ENST00000458432.2_Silent_p.L111L	NM_001276347.1	NP_001263276.1	P45379	TNNT2_HUMAN	troponin T type 2 (cardiac)	109					ATP catabolic process|muscle filament sliding|negative regulation of ATPase activity|positive regulation of ATPase activity|regulation of heart contraction|response to calcium ion|ventricular cardiac muscle tissue morphogenesis	cytosol|troponin complex	actin binding|tropomyosin binding|troponin C binding|troponin I binding			breast(2)|cervix(1)|endometrium(3)|large_intestine(4)|liver(1)|lung(9)	20						GCAACTCATTCAGGTCCTTCT	0.567000													18	103					0	0	1	0	0
TTC14	151613	broad.mit.edu	37	3	180322328	180322328	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr3:180322328C>T	ENST00000412756.2	+	5	703	c.634C>T	c.(634-636)Ctt>Ttt	p.L212F	TTC14_ENST00000296015.4_Missense_Mutation_p.L212F|TTC14_ENST00000382584.4_Missense_Mutation_p.L212F	NM_001042601.2	NP_001036066.1	Q96N46	TTC14_HUMAN	tetratricopeptide repeat domain 14	212							RNA binding			endometrium(3)|kidney(5)|large_intestine(9)|lung(24)|ovary(2)|pancreas(1)|skin(1)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			TAGCTCTTCTCTTCCACCACA	0.338000													14	75					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237806743	237806743	+	Silent	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr1:237806743C>T	ENST00000366574.2	+	48	7655	c.7338C>T	c.(7336-7338)gcC>gcT	p.A2446A	RYR2_ENST00000360064.6_Silent_p.A2444A|RYR2_ENST00000542537.1_Silent_p.A2430A	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	2446	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CAACAATAGCCAAAGGTAAGG	0.443000													8	49					0	0	1	0	0
UBR5	51366	broad.mit.edu	37	8	103291080	103291080	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr8:103291080C>A	ENST00000520539.1	-	44	6868	c.6262G>T	c.(6262-6264)Gtt>Ttt	p.V2088F	UBR5_ENST00000521922.1_Missense_Mutation_p.V2082F|UBR5_ENST00000220959.4_Missense_Mutation_p.V2088F	NM_001282873.1|NM_015902.5	NP_001269802.1|NP_056986.2	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin 5	2088					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			NS(1)|breast(13)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(19)|liver(1)|lung(51)|ovary(6)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	124	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			TCCACTGTAACCTCCATTAAA	0.368000													8	144					0.000274275	0.000284919	1	1	0
BAZ1A	11177	broad.mit.edu	37	14	35234010	35234010	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr14:35234010C>A	ENST00000360310.1	-	23	4246	c.3679G>T	c.(3679-3681)Gat>Tat	p.D1227Y	BAZ1A_ENST00000382422.2_Missense_Mutation_p.D1227Y|BAZ1A_ENST00000358716.4_Missense_Mutation_p.D1195Y	NM_013448.2	NP_038476.2	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	1227					chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(2)|large_intestine(7)|lung(19)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		tcaacttcatcatcctcACCT	0.443000													15	58					0.000219431	0.0002314	1	1	0
LRBA	987	broad.mit.edu	37	4	151408924	151408924	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr4:151408924G>A	ENST00000535741.1	-	42	6984	c.6511C>T	c.(6511-6513)Cgt>Tgt	p.R2171C	LRBA_ENST00000503716.1_5'UTR|LRBA_ENST00000357115.3_Missense_Mutation_p.R2182C|LRBA_ENST00000507224.1_Missense_Mutation_p.R2171C|LRBA_ENST00000510413.1_Missense_Mutation_p.R2171C			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	2182						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					ACGCCAACACGAGGTAGATAG	0.343000													8	51					0	0	1	0	0
BAZ2B	29994	broad.mit.edu	37	2	160205274	160205274	+	Silent	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr2:160205274G>A	ENST00000392783.2	-	30	5703	c.5208C>T	c.(5206-5208)ctC>ctT	p.L1736L	BAZ2B_ENST00000355831.2_Silent_p.L1702L|BAZ2B_ENST00000343439.5_Silent_p.L1636L|BAZ2B_ENST00000392782.1_Silent_p.L1700L	NM_013450.2	NP_038478.2	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1736					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(7)|liver(2)|lung(41)|ovary(3)|prostate(1)|skin(2)|soft_tissue(1)|urinary_tract(1)	82						TTATTCCTCTGAGATGCAGCA	0.358000													6	58					0	0	1	0	0
SCAND3	114821	broad.mit.edu	37	6	28543158	28543158	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr6:28543158A>G	ENST00000452236.2	-	3	1941	c.1324T>C	c.(1324-1326)Ttt>Ctt	p.F442L		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	442	Integrase catalytic.				DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						TGGCTTGAAAATTCCCTCCCA	0.413000													12	90					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577559	7577559	+	Missense_Mutation	SNP	G	G	A	rs28934573		TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr17:7577559G>A	ENST00000420246.2	-	7	854	c.722C>T	c.(721-723)tCc>tTc	p.S241F	TP53_ENST00000269305.4_Missense_Mutation_p.S241F|TP53_ENST00000455263.2_Missense_Mutation_p.S241F|TP53_ENST00000413465.2_Missense_Mutation_p.S241F|TP53_ENST00000359597.4_Missense_Mutation_p.S241F|TP53_ENST00000445888.2_Missense_Mutation_p.S241F	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	241	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.		S -> A (in sporadic cancers; somatic mutation).|S -> C (in sporadic cancers; somatic mutation).|S -> F (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934573).|S -> P (in sporadic cancers; somatic mutation).|S -> T (in LFS; germline mutation and in sporadic cancers; somatic mutation).|S -> Y (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.S241F(85)|p.S241C(26)|p.0?(8)|p.S241Y(8)|p.C242fs*5(6)|p.?(5)|p.S241del(5)|p.S148F(4)|p.N239_C242delNSSC(3)|p.N239_C242>S(1)|p.C238fs*21(1)|p.S241fs*22(1)|p.N239_C242del(1)|p.Y236_M243delYMCNSSCM(1)|p.S241_G245delSCMGG(1)|p.S148C(1)|p.N239fs*4(1)|p.C238_M246delCNSSCMGGM(1)|p.H233_C242del10(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCCCATGCAGGAACTGTTACA	0.572000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			8	39					0	0	1	0	0
GIGYF2	26058	broad.mit.edu	37	2	233710508	233710508	+	Silent	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr2:233710508C>G	ENST00000373566.3	+	27	3635	c.3438C>G	c.(3436-3438)ctC>ctG	p.L1146L	GIGYF2_ENST00000409196.3_Silent_p.L1118L|GIGYF2_ENST00000409451.3_Silent_p.L1145L|GIGYF2_ENST00000409547.1_Silent_p.L1124L|GIGYF2_ENST00000373563.4_Silent_p.L1124L|GIGYF2_ENST00000409480.1_Silent_p.L1146L			Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2	1124					cell death		protein binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(17)|lung(11)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	63		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		TGCTGAAGCTCTTTCAGGGAG	0.393000													6	50					0	0	1	0	0
PRMT7	54496	broad.mit.edu	37	16	68373809	68373809	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr16:68373809G>A	ENST00000339507.5	+	9	1695	c.865G>A	c.(865-867)Gag>Aag	p.E289K	PRMT7_ENST00000441236.1_Missense_Mutation_p.E239K|PRMT7_ENST00000564441.1_3'UTR|PRMT7_ENST00000348497.4_Missense_Mutation_p.E215K|PRMT7_ENST00000449359.3_Missense_Mutation_p.E239K			Q9NVM4	ANM7_HUMAN	protein arginine methyltransferase 7	289					cell differentiation|DNA methylation involved in gamete generation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	[myelin basic protein]-arginine N-methyltransferase activity|histone methyltransferase activity (H4-R3 specific)|protein-arginine omega-N monomethyltransferase activity|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(10)|pancreas(1)|urinary_tract(1)	20		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0155)|Epithelial(162;0.0629)		AATGGACCCTGAGGGGAAGAT	0.572000													3	36					0	0	1	0	0
ACLY	47	broad.mit.edu	37	17	40042550	40042550	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr17:40042550G>C	ENST00000352035.2	-	18	2017	c.1887C>G	c.(1885-1887)atC>atG	p.I629M	ACLY_ENST00000590151.1_Missense_Mutation_p.I629M|ACLY_ENST00000537919.1_Missense_Mutation_p.I358M|ACLY_ENST00000353196.1_Missense_Mutation_p.I619M|ACLY_ENST00000393896.2_Missense_Mutation_p.I619M	NM_001096.2	NP_001087.2	P53396	ACLY_HUMAN	ATP citrate lyase	629					ATP catabolic process|cellular carbohydrate metabolic process|citrate metabolic process|coenzyme A metabolic process|energy reserve metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	citrate lyase complex|cytosol|nucleus	ATP binding|ATP citrate synthase activity|citrate (pro-3S)-lyase activity|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity		NTN1/ACLY(2)	breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(4)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	28		Breast(137;0.000143)				ACCCAGGCTTGATGCCTCCAA	0.552000													4	22					0	0	1	0	0
CLSPN	63967	broad.mit.edu	37	1	36235452	36235452	+	Missense_Mutation	SNP	G	G	A	rs151142512	byFrequency	TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr1:36235452G>A	ENST00000251195.5	-	1	116	c.20C>T	c.(19-21)tCt>tTt	p.S7F	CLSPN_ENST00000520551.1_Missense_Mutation_p.S7F|CLSPN_ENST00000373220.3_Missense_Mutation_p.S7F|CLSPN_ENST00000318121.3_Missense_Mutation_p.S7F			Q9HAW4	CLSPN_HUMAN	claspin	7					activation of protein kinase activity|cell cycle|cellular component disassembly involved in apoptosis|DNA repair|DNA replication|G2/M transition DNA damage checkpoint|mitotic cell cycle DNA replication checkpoint|peptidyl-serine phosphorylation	nucleoplasm	anaphase-promoting complex binding|DNA binding			NS(2)|breast(3)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				ACTCACCTCAGAACCCACCTC	0.677000													18	46					0	0	1	0	0
SCG3	29106	broad.mit.edu	37	15	51984443	51984443	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr15:51984443G>A	ENST00000220478.3	+	7	1181	c.778G>A	c.(778-780)Gaa>Aaa	p.E260K	SCG3_ENST00000542355.2_Missense_Mutation_p.E28K	NM_013243.3	NP_037375.2	Q8WXD2	SCG3_HUMAN	secretogranin III	260					platelet activation|platelet degranulation	extracellular region|stored secretory granule				breast(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21				all cancers(107;0.00488)		AAATGGCTTGGAAAGGAGAAC	0.403000													4	80					0	0	1	0	0
SLC7A9	11136	broad.mit.edu	37	19	33349388	33349388	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr19:33349388G>A	ENST00000023064.4	-	9	1126	c.935C>T	c.(934-936)tCa>tTa	p.S312L	SLC7A9_ENST00000590341.1_Missense_Mutation_p.S312L|SLC7A9_ENST00000587772.1_Missense_Mutation_p.S312L	NM_001126335.1|NM_001243036.1|NM_014270.4	NP_001119807.1|NP_001229965.1|NP_055085.1	P82251	BAT1_HUMAN	solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9	312					blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	integral to plasma membrane	L-cystine transmembrane transporter activity|neutral amino acid transmembrane transporter activity|peptide antigen binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	32	Esophageal squamous(110;0.137)				L-Cystine(DB00138)	ACCGATGGTTGAAAATGCCAC	0.552000													3	17					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13721340	13721340	+	Silent	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr5:13721340G>A	ENST00000265104.4	-	71	12152	c.12048C>T	c.(12046-12048)atC>atT	p.I4016I		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4016	AAA 6 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TGGAGTCCACGATGTACTTGC	0.428000									Kartagener syndrome				10	74					0	0	1	0	0
PYGB	5834	broad.mit.edu	37	20	25273202	25273202	+	Silent	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr20:25273202C>T	ENST00000216962.4	+	17	2240	c.2130C>T	c.(2128-2130)ttC>ttT	p.F710F		NM_002862.3	NP_002853.2	P11216	PYGB_HUMAN	phosphorylase, glycogen; brain	710					glucose metabolic process|glycogen catabolic process	cytoplasm	glycogen phosphorylase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	31					Pyridoxal Phosphate(DB00114)	AGAACCTCTTCATCTTCGGCC	0.647000													7	35					0	0	1	0	0
NPFFR2	10886	broad.mit.edu	37	4	72994449	72994449	+	Silent	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr4:72994449C>T	ENST00000308744.6	+	2	545	c.447C>T	c.(445-447)atC>atT	p.I149I	NPFFR2_ENST00000358749.3_Silent_p.I47I|NPFFR2_ENST00000395999.1_Silent_p.I50I|NPFFR2_ENST00000344413.5_Intron	NM_004885.2	NP_004876.2	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2	149					detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(24)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	43			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			TGGCAGCAATCTTCATTATTT	0.368000													7	83					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62296260	62296260	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr11:62296260C>T	ENST00000378024.4	-	5	5903	c.5629G>A	c.(5629-5631)Gtg>Atg	p.V1877M	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	1877					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				AATTTTGGCACCGACACATCC	0.517000													23	203					0	0	1	0	0
NSD1	64324	broad.mit.edu	37	5	176696774	176696774	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr5:176696774G>C	ENST00000439151.2	+	16	5520	c.5475G>C	c.(5473-5475)aaG>aaC	p.K1825N	NSD1_ENST00000361032.4_Missense_Mutation_p.K1722N|NSD1_ENST00000347982.4_Missense_Mutation_p.K1556N|NSD1_ENST00000354179.4_Missense_Mutation_p.K1556N	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1825					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		GCAAGGATAAGATGGGCAAAG	0.448000			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			15	43					0	0	1	0	0
CFHR3	10878	broad.mit.edu	37	1	196744061	196744061	+	Silent	SNP	T	T	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr1:196744061T>C	ENST00000471440.2	+	1	119	c.45T>C	c.(43-45)tgT>tgC	p.C15C	CFHR3_ENST00000367425.4_Silent_p.C15C|CFHR3_ENST00000391985.3_Silent_p.C15C					complement factor H-related 3											breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|lung(6)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	18						GGGTTTCCTGTGCTAATGGAC	0.333000													7	60					0	0	1	0	0
FBXL5	26234	broad.mit.edu	37	4	15627442	15627442	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr4:15627442G>A	ENST00000341285.3	-	9	1407	c.1283C>T	c.(1282-1284)tCa>tTa	p.S428L	FBXL5_ENST00000412094.2_Missense_Mutation_p.S411L|FBXL5_ENST00000382358.4_Missense_Mutation_p.S302L	NM_001193534.1|NM_001193535.1|NM_012161.3	NP_001180463.1|NP_001180464.1|NP_036293.1	Q9UKA1	FBXL5_HUMAN	F-box and leucine-rich repeat protein 5	428					iron ion homeostasis|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|SCF ubiquitin ligase complex	iron ion binding|protein binding|ubiquitin-protein ligase activity			endometrium(2)|large_intestine(3)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	13						CCACGCAGTTGAAGTAATTTT	0.383000													9	80					0	0	1	0	0
LST1	7940	broad.mit.edu	37	6	31555734	31555734	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr6:31555734G>C	ENST00000438075.2	+	4	363	c.126G>C	c.(124-126)gaG>gaC	p.E42D	LST1_ENST00000376111.4_5'UTR|LST1_ENST00000376102.3_Intron|LST1_ENST00000418507.2_Missense_Mutation_p.E11D|LST1_ENST00000376089.2_Missense_Mutation_p.E11D|LST1_ENST00000376100.3_Intron|LST1_ENST00000376099.1_Intron|LST1_ENST00000303757.8_Intron|LST1_ENST00000376093.2_Missense_Mutation_p.E42D|LST1_ENST00000376110.3_Missense_Mutation_p.E11D|LST1_ENST00000376086.3_Missense_Mutation_p.E11D|LST1_ENST00000376090.2_Intron|LST1_ENST00000376092.3_Intron|LST1_ENST00000339530.4_Intron|LST1_ENST00000376096.1_Intron|LST1_ENST00000396101.3_Intron|LST1_ENST00000211921.7_Intron	NM_205839.2	NP_995311.2	O00453	LST1_HUMAN	leukocyte specific transcript 1	42					cell morphogenesis|dendrite development|immune response|negative regulation of lymphocyte proliferation|regulation of cell shape	Golgi membrane|integral to membrane	protein binding			large_intestine(1)	1						AGAGGCTGGAGAGGAGCTGGG	0.622000													4	22					0	0	1	0	0
BCL9L	283149	broad.mit.edu	37	11	118772178	118772178	+	Silent	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr11:118772178C>T	ENST00000334801.3	-	6	3238	c.2274G>A	c.(2272-2274)ctG>ctA	p.L758L	BCL9L_ENST00000526143.1_5'UTR	NM_182557.2	NP_872363.1	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	758	Met-rich.				negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	56	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		CCACCTCCCTCAGCCCAGACT	0.622000													4	33					0	0	1	0	0
SLC28A1	9154	broad.mit.edu	37	15	85476467	85476467	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr15:85476467C>A	ENST00000394573.1	+	13	1377	c.1175C>A	c.(1174-1176)tCc>tAc	p.S392Y	SLC28A1_ENST00000538177.1_Intron|SLC28A1_ENST00000286749.3_Missense_Mutation_p.S392Y|SLC28A1_ENST00000537216.1_Missense_Mutation_p.S392Y|SLC28A1_ENST00000537624.1_Missense_Mutation_p.S392Y	NM_004213.3	NP_004204.3	O00337	S28A1_HUMAN	solute carrier family 28 (concentrative nucleoside transporter), member 1	392					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	41			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GTGGAGGAGTCCAAGTTTAGG	0.582000													4	67					0.00909568	0.00936478	1	1	0
DCAF17	80067	broad.mit.edu	37	2	172336557	172336557	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr2:172336557A>G	ENST00000375255.3	+	13	1603	c.1276A>G	c.(1276-1278)Att>Gtt	p.I426V	DCAF17_ENST00000468592.1_3'UTR|DCAF17_ENST00000539783.1_Missense_Mutation_p.I359V	NM_025000.3	NP_079276.2	Q5H9S7	DCA17_HUMAN	DDB1 and CUL4 associated factor 17	426						CUL4 RING ubiquitin ligase complex|integral to membrane|nucleolus				endometrium(1)|kidney(2)|large_intestine(3)|lung(10)|prostate(1)	17						GACTTTCAAAATTGTGGACTA	0.343000													17	49					0	0	1	0	0
ABCA7	10347	broad.mit.edu	37	19	1044664	1044664	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr19:1044664C>T	ENST00000263094.6	+	11	1367	c.1136C>T	c.(1135-1137)cCt>cTt	p.P379L	ABCA7_ENST00000433129.1_Missense_Mutation_p.P379L|ABCA7_ENST00000435683.2_Missense_Mutation_p.P241L	NM_019112.3	NP_061985.2	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 7	379					phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			NS(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(7)|lung(22)|ovary(1)|pancreas(7)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTTCTGGACCCTGGGAGCGGT	0.682000													4	29					0	0	1	0	0
HAUS6	54801	broad.mit.edu	37	9	19078279	19078279	+	Silent	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr9:19078279G>C	ENST00000380502.3	-	10	1553	c.1086C>G	c.(1084-1086)ctC>ctG	p.L362L	HAUS6_ENST00000380496.1_Silent_p.L226L	NM_001270890.1|NM_017645.4	NP_001257819.1|NP_060115.3	Q7Z4H7	HAUS6_HUMAN	HAUS augmin-like complex, subunit 6	362					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|nucleus|spindle				autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						TTATAGTTGTGAGATCATCTT	0.279000													4	51					0	0	1	0	0
KLF17	128209	broad.mit.edu	37	1	44595068	44595068	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr1:44595068C>A	ENST00000372299.3	+	2	183	c.125C>A	c.(124-126)tCt>tAt	p.S42Y	KLF17_ENST00000476802.1_3'UTR	NM_173484.3	NP_775755.3	Q5JT82	KLF17_HUMAN	Kruppel-like factor 17	42					regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|large_intestine(1)|lung(6)|ovary(3)|prostate(1)|skin(2)|stomach(1)	18	Acute lymphoblastic leukemia(166;0.155)					TCTTCATCTTCTGGAAGCTCT	0.498000													15	74					1.15088e-07	1.25158e-07	1	1	0
ZNF224	7767	broad.mit.edu	37	19	44611924	44611924	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr19:44611924G>C	ENST00000336976.6	+	6	1865	c.1611G>C	c.(1609-1611)gaG>gaC	p.E537D	AC084219.4_ENST00000592946.1_RNA	NM_013398.2	NP_037530.2	Q9NZL3	ZN224_HUMAN	zinc finger protein 224	537					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(2)|ovary(2)|prostate(1)|stomach(2)|urinary_tract(1)	19		Prostate(69;0.0435)				ACACAGGAGAGAGACCATACA	0.428000													8	88					0	0	1	0	0
ADCY5	111	broad.mit.edu	37	3	123014951	123014951	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr3:123014951C>G	ENST00000462833.1	-	17	4255	c.3043G>C	c.(3043-3045)Gac>Cac	p.D1015H	ADCY5_ENST00000491190.1_Missense_Mutation_p.D673H|ADCY5_ENST00000309879.5_Missense_Mutation_p.D665H	NM_183357.2	NP_899200.1	O95622	ADCY5_HUMAN	adenylate cyclase 5	1015					activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(22)|ovary(5)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(114;0.0342)		CAGAGGAAGTCGAGGCGGGCA	0.632000													9	19					0	0	1	0	0
C1QTNF7	114905	broad.mit.edu	37	4	15444375	15444375	+	Nonsense_Mutation	SNP	C	C	A	rs144156971	by1000genomes	TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr4:15444375C>A	ENST00000295297.4	+	3	1102	c.843C>A	c.(841-843)taC>taA	p.Y281*	C1QTNF7_ENST00000444304.2_Nonsense_Mutation_p.Y274*|C1QTNF7_ENST00000429690.1_Nonsense_Mutation_p.Y274*	NM_001135170.1	NP_001128642.1	Q9BXJ2	C1QT7_HUMAN	C1q and tumor necrosis factor related protein 7	274						collagen		p.Y274Y(1)		endometrium(5)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|stomach(1)	16						TTCTCTTATACGTTGACACAG	0.453000													8	96					5.18039e-06	5.547e-06	1	1	0
GYPA	2993	broad.mit.edu	37	4	145035857	145035857	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr4:145035857C>A	ENST00000360771.4	-	6	536	c.421G>T	c.(421-423)Gaa>Taa	p.E141*	GYPA_ENST00000324022.10_Nonsense_Mutation_p.E108*|GYPA_ENST00000512064.1_Nonsense_Mutation_p.E128*|GYPA_ENST00000535709.1_Nonsense_Mutation_p.E115*|GYPB_ENST00000283126.7_Intron|GYPA_ENST00000503627.1_Nonsense_Mutation_p.E96*|RP11-673E1.4_ENST00000506982.1_RNA|GYPA_ENST00000512789.1_Nonsense_Mutation_p.E76*|GYPA_ENST00000504786.1_Nonsense_Mutation_p.E109*	NM_002099.6	NP_002090.4	P02724	GLPA_HUMAN	glycophorin A (MNS blood group)	141					interspecies interaction between organisms	membrane fraction	receptor activity			central_nervous_system(2)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)	10	all_hematologic(180;0.15)					TTTTCTATTTCAACAGAACTT	0.353000													12	24					1.5842e-08	1.73912e-08	1	1	0
MTMR2	8898	broad.mit.edu	37	11	95582905	95582905	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr11:95582905G>A	ENST00000393223.3	-	11	1372	c.710C>T	c.(709-711)tCc>tTc	p.S237F	MTMR2_ENST00000409459.1_Missense_Mutation_p.S237F|MTMR2_ENST00000352297.7_Missense_Mutation_p.S237F|MTMR2_ENST00000346299.5_Missense_Mutation_p.S309F	NM_001243571.1|NM_201278.2	NP_001230500.1|NP_958435.1	Q13614	MTMR2_HUMAN	myotubularin related protein 2	309	Myotubularin phosphatase.					nucleus	inositol or phosphatidylinositol phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	19		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CTGGGCATTGGAATCCATGAT	0.423000													10	112					0	0	1	0	0
OR5M10	390167	broad.mit.edu	37	11	56344681	56344681	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr11:56344681C>G	ENST00000526812.2	-	1	582	c.517G>C	c.(517-519)Gaa>Caa	p.E173Q		NM_001004741.1	NP_001004741.1	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M, member 10	173					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(15)|upper_aerodigestive_tract(2)|urinary_tract(2)	25						TGATTGATTTCAAGGGAGCCA	0.468000													7	42					0	0	1	0	0
LRRK1	79705	broad.mit.edu	37	15	101589897	101589897	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr15:101589897G>A	ENST00000284395.5	+	24	3739	c.3339G>A	c.(3337-3339)atG>atA	p.M1113I	LRRK1_ENST00000388948.3_Missense_Mutation_p.M1116I			Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	1116					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(25)|ovary(4)|prostate(1)|skin(1)	72	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			GCGGAGGAATGAAAATTGTTT	0.493000													5	73					0	0	1	0	0
CCDC149	91050	broad.mit.edu	37	4	24839880	24839880	+	Silent	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr4:24839880C>T	ENST00000504487.1	-	5	393	c.387G>A	c.(385-387)acG>acA	p.T129T	CCDC149_ENST00000428116.2_Intron|CCDC149_ENST00000502801.1_Intron|CCDC149_ENST00000389609.4_Silent_p.T129T	NM_001130726.2	NP_001124198.1	B4DZG3	B4DZG3_HUMAN	coiled-coil domain containing 149	129										cervix(1)|endometrium(1)|large_intestine(2)|lung(3)	7		Breast(46;0.173)				GTTTGGCAATCGTCATCCTCA	0.458000													3	74					0	0	1	0	0
LARP4B	23185	broad.mit.edu	37	10	860928	860928	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr10:860928G>T	ENST00000316157.3	-	15	1818	c.1778C>A	c.(1777-1779)tCa>tAa	p.S593*	LARP4B_ENST00000469487.1_5'UTR	NM_015155.1	NP_055970.1	Q92615	LAR4B_HUMAN	La ribonucleoprotein domain family, member 4B	593							nucleotide binding|RNA binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(2)|skin(2)|urinary_tract(2)	38						GTACGTTGCTGATACAGCACA	0.557000													8	21					5.4927e-09	6.06813e-09	1	1	0
S100A9	6280	broad.mit.edu	37	1	153333125	153333125	+	Silent	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr1:153333125G>A	ENST00000368738.3	+	3	199	c.156G>A	c.(154-156)gaG>gaA	p.E52E		NM_002965.3	NP_002956.1	P06702	S10A9_HUMAN	S100 calcium binding protein A9	52					cell-cell signaling	cytoplasm|cytoskeleton|nucleus|plasma membrane	calcium ion binding|protein binding|signal transducer activity			breast(1)|endometrium(1)|large_intestine(2)	4	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			CGCAGAAGGAGAATAAGAATG	0.527000													18	53					0	0	1	0	0
DPP3	10072	broad.mit.edu	37	11	66276567	66276567	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr11:66276567C>G	ENST00000532677.1	+	18	2517	c.2116C>G	c.(2116-2118)Ctg>Gtg	p.L706V	DPP3_ENST00000531863.1_Missense_Mutation_p.L707V|DPP3_ENST00000530165.1_Missense_Mutation_p.L657V|DPP3_ENST00000541961.1_Missense_Mutation_p.L687V|DPP3_ENST00000453114.1_Missense_Mutation_p.L687V|CTD-3074O7.11_ENST00000419755.3_5'UTR|DPP3_ENST00000360510.2_Missense_Mutation_p.L687V	NM_001256670.1|NM_005700.4|NM_130443.3	NP_001243599.1|NP_005691.2|NP_569710.2	Q9NY33	DPP3_HUMAN	dipeptidyl-peptidase 3	687					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)	23						CGTGCAGCTTCTGGAATACGA	0.507000													8	51					0	0	1	0	0
RB1	5925	broad.mit.edu	37	13	48919281	48919281	+	Nonsense_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr13:48919281C>G	ENST00000267163.4	+	4	584	c.446C>G	c.(445-447)tCa>tGa	p.S149*		NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1	149					androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(6)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AATGCTATGTCAAGACTGTTG	0.289000		6	"""D, Mis, N, F, S"""		"""retinoblastoma, sarcoma, breast, small cell lung"""	"""retinoblastoma, sarcoma, breast, small cell lung"""			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			31	125					0	0	1	0	0
LRRC16A	55604	broad.mit.edu	37	6	25479352	25479352	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr6:25479352C>G	ENST00000377969.3	+	12	1040	c.408C>G	c.(406-408)atC>atG	p.I136M	LRRC16A_ENST00000329474.6_Intron			Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	0					actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				breast(4)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	50						ctaccaagatcaagagacaga	0.438000													20	154					0	0	1	0	0
KMT2A	4297	broad.mit.edu	37	11	118371720	118371720	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr11:118371720G>A	ENST00000534358.1	+	25	6200	c.6177G>A	c.(6175-6177)tgG>tgA	p.W2059*	KMT2A_ENST00000389506.5_Nonsense_Mutation_p.W2056*|KMT2A_ENST00000354520.4_Nonsense_Mutation_p.W2018*	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		GGGTATACTGGAGCACCACAG	0.458000													10	49					0	0	1	0	0
RGPD8	727851	broad.mit.edu	37	2	113127775	113127775	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr2:113127775G>C	ENST00000302558.3	-	23	5469	c.5278C>G	c.(5278-5280)Cct>Gct	p.P1760A	RGPD8_ENST00000409750.1_Missense_Mutation_p.P1620A	NM_001164463.1	NP_001157935.1			RANBP2-like and GRIP domain containing 8									p.P1760A(12)		endometrium(4)|kidney(1)|lung(1)|prostate(3)|urinary_tract(1)	10						GAACGGGAAGGATTTTCTTCC	0.308000													4	80					0	0	1	0	0
MYRF	745	broad.mit.edu	37	11	61548735	61548735	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr11:61548735C>G	ENST00000278836.5	+	21	2794	c.2698C>G	c.(2698-2700)Ctt>Gtt	p.L900V	MYRF_ENST00000265460.5_Missense_Mutation_p.L865V|TMEM258_ENST00000535042.1_Intron|MYRF_ENST00000389602.4_Missense_Mutation_p.L291V	NM_001127392.1	NP_001120864.1			myelin regulatory factor																		tggtcctagtcttggccccag	0.617000													9	32					0	0	1	0	0
F13A1	2162	broad.mit.edu	37	6	6145933	6145933	+	Silent	SNP	C	C	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr6:6145933C>A	ENST00000264870.3	-	15	2383	c.2118G>T	c.(2116-2118)ctG>ctT	p.L706L		NM_000129.3	NP_000120.2	P00488	F13A_HUMAN	coagulation factor XIII, A1 polypeptide	706					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	TGCTGGCTATCAGCTTCCGAT	0.547000													4	76					0.00024832	0.000258729	1	1	0
SRRM2	23524	broad.mit.edu	37	16	2815271	2815271	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr16:2815271C>T	ENST00000301740.8	+	11	5291	c.4742C>T	c.(4741-4743)tCa>tTa	p.S1581L		NM_016333.3	NP_057417.3	Q9UQ35	SRRM2_HUMAN	serine/arginine repetitive matrix 2	1581	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|lung(34)|ovary(6)|pancreas(3)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(7)	105						CGGTCTGGATCATCTCCAGAG	0.532000													5	48					0	0	1	0	0
SLFNL1	200172	broad.mit.edu	37	1	41481862	41481862	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr1:41481862C>T	ENST00000359345.1	-	4	3716	c.1140G>A	c.(1138-1140)atG>atA	p.M380I	SLFNL1_ENST00000439569.2_Missense_Mutation_p.M380I|SLFNL1_ENST00000397197.2_Missense_Mutation_p.M332I|SLFNL1_ENST00000372613.2_Missense_Mutation_p.M332I|SLFNL1_ENST00000372611.1_Missense_Mutation_p.M321I|SLFNL1_ENST00000302946.8_Missense_Mutation_p.M380I	NM_144990.3	NP_659427.3	Q499Z3	SLNL1_HUMAN	schlafen-like 1	380							ATP binding			endometrium(3)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	10	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Breast(333;0.1)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0393)				TCAGCGCCTTCATCTTCTCTT	0.642000													6	58					0	0	1	0	0
RAB11FIP1	80223	broad.mit.edu	37	8	37734845	37734845	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr8:37734845G>A	ENST00000330843.4	-	2	608	c.596C>T	c.(595-597)tCg>tTg	p.S199L	RAB11FIP1_ENST00000524118.1_Missense_Mutation_p.S51L|RAB11FIP1_ENST00000287263.4_Missense_Mutation_p.S199L|RAB11FIP1_ENST00000522727.1_Missense_Mutation_p.S51L	NM_001002814.2	NP_001002814.2	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 (class I)	199					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			NS(1)|breast(1)|central_nervous_system(4)|endometrium(3)|large_intestine(6)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	49		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			ACTGTCGACCGAAGGTGTCGT	0.463000													11	110					0	0	1	0	0
LMOD3	56203	broad.mit.edu	37	3	69168492	69168492	+	Silent	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr3:69168492C>T	ENST00000420581.2	-	2	1193	c.1014G>A	c.(1012-1014)gaG>gaA	p.E338E	LMOD3_ENST00000489031.1_Silent_p.E338E|LMOD3_ENST00000475434.1_Silent_p.E338E	NM_198271.3	NP_938012.2	Q0VAK6	LMOD3_HUMAN	leiomodin 3 (fetal)	338						cytoplasm|cytoskeleton	tropomyosin binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(1)	13		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;7.88e-05)|Epithelial(33;0.000839)|LUSC - Lung squamous cell carcinoma(21;0.0119)|Lung(16;0.0191)|KIRC - Kidney renal clear cell carcinoma(39;0.205)|Kidney(39;0.24)		CAGTTAGCGTCTCATTAAACT	0.453000													23	202					0	0	1	0	0
IP6K3	117283	broad.mit.edu	37	6	33690952	33690952	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr6:33690952C>T	ENST00000451316.1	-	7	1313	c.778G>A	c.(778-780)Gat>Aat	p.D260N	IP6K3_ENST00000293756.4_Missense_Mutation_p.D260N	NM_001142883.1	NP_001136355.1	Q96PC2	IP6K3_HUMAN	inositol hexakisphosphate kinase 3	260					inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|protein phosphorylation	cytoplasm	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol hexakisphosphate 6-kinase activity|inositol trisphosphate 3-kinase activity			skin(1)	1						TACTTCTTATCTGTTTGATAA	0.368000													5	21					0	0	1	0	0
DMXL1	1657	broad.mit.edu	37	5	118500301	118500301	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr5:118500301C>G	ENST00000311085.8	+	20	4882	c.4802C>G	c.(4801-4803)tCt>tGt	p.S1601C	DMXL1_ENST00000539542.1_Missense_Mutation_p.S1601C	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	1601										breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		CCCACTTGGTCTGAACTAAGA	0.448000													9	52					0	0	1	0	0
ATXN2L	11273	broad.mit.edu	37	16	28841315	28841315	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr16:28841315G>C	ENST00000336783.4	+	8	1137	c.970G>C	c.(970-972)Gag>Cag	p.E324Q	ATXN2L_ENST00000564304.1_Missense_Mutation_p.E324Q|ATXN2L_ENST00000340394.8_Missense_Mutation_p.E324Q|ATXN2L_ENST00000325215.6_Missense_Mutation_p.E324Q|ATXN2L_ENST00000570200.1_Missense_Mutation_p.E324Q|ATXN2L_ENST00000395547.2_Missense_Mutation_p.E324Q|ATXN2L_ENST00000382686.4_Missense_Mutation_p.E324Q	NM_007245.3	NP_009176.2	Q8WWM7	ATX2L_HUMAN	ataxin 2-like	324						membrane				breast(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36						GCGCACTGAAGAGGAGAAGCA	0.617000													16	24					0	0	1	0	0
WEE2	494551	broad.mit.edu	37	7	141414017	141414017	+	Silent	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr7:141414017G>A	ENST00000397541.2	+	2	757	c.351G>A	c.(349-351)ctG>ctA	p.L117L	WEE2-AS1_ENST00000488785.1_RNA|WEE2-AS1_ENST00000465110.1_RNA|WEE2-AS1_ENST00000495800.1_RNA|WEE2-AS1_ENST00000471512.1_RNA|WEE2-AS1_ENST00000478332.1_RNA|WEE2-AS1_ENST00000462383.1_RNA|WEE2-AS1_ENST00000459753.1_RNA	NM_001105558.1	NP_001099028.1	P0C1S8	WEE2_HUMAN	WEE1 homolog 2 (S. pombe)	117					egg activation|female meiosis|female pronucleus assembly|meiotic metaphase II|meiotic prophase I|mitosis|negative regulation of oocyte development|regulation of meiosis I	centrosome|nucleus	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(2)|stomach(1)	31	Melanoma(164;0.0171)					AGACCATGCTGAGCCGGTTGG	0.433000													17	66					0	0	1	0	0
ANKDD1A	348094	broad.mit.edu	37	15	65208100	65208100	+	Splice_Site	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr15:65208100G>C	ENST00000380230.3	+	2	167		c.e2+1		ANKDD1A_ENST00000395720.1_Splice_Site|AC069368.3_ENST00000437723.1_Intron|ANKDD1A_ENST00000319580.8_Intron|ANKDD1A_ENST00000496660.1_Intron|ANKDD1A_ENST00000491145.1_Splice_Site|ANKDD1A_ENST00000357698.3_Splice_Site	NM_182703.3	NP_874362.3	Q495B1	AKD1A_HUMAN	ankyrin repeat and death domain containing 1A						signal transduction					NS(1)|endometrium(1)|large_intestine(10)|liver(2)|lung(4)|ovary(1)|prostate(2)	21						CAGAAACCACGTGCGTAATGA	0.552000													3	15					0	0	1	0	0
CXorf56	63932	broad.mit.edu	37	X	118676491	118676491	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chrX:118676491C>T	ENST00000320339.4	-	5	614	c.343G>A	c.(343-345)Gaa>Aaa	p.E115K	CXorf56_ENST00000536133.1_Missense_Mutation_p.E150K|CXorf56_ENST00000371594.4_Missense_Mutation_p.E164K|CXorf56_ENST00000469448.1_5'UTR	NM_001170569.1	NP_001164040.1	Q9H5V9	CX056_HUMAN	chromosome X open reading frame 56	164							protein binding			cervix(1)|endometrium(2)|lung(7)	10						TCTTCCTCTTCATCAATGGTA	0.507000													20	34					0	0	1	0	0
C3orf20	84077	broad.mit.edu	37	3	14746102	14746102	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr3:14746102C>G	ENST00000253697.3	+	7	1589	c.1137C>G	c.(1135-1137)ttC>ttG	p.F379L	C3orf20_ENST00000495387.1_3'UTR|C3orf20_ENST00000435614.1_Missense_Mutation_p.F257L|C3orf20_ENST00000412910.1_Missense_Mutation_p.F257L	NM_032137.4	NP_115513.4	Q8ND61	CC020_HUMAN	chromosome 3 open reading frame 20	379						cytoplasm|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(13)|lung(11)|ovary(4)|skin(2)	40						ATTACACCTTCTATGATGGCT	0.483000													10	88					0	0	1	0	0
VPS9D1	9605	broad.mit.edu	37	16	89776196	89776196	+	Silent	SNP	C	C	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr16:89776196C>A	ENST00000561976.1	-	10	1544	c.1167G>T	c.(1165-1167)ctG>ctT	p.L389L	VPS9D1_ENST00000389386.3_Silent_p.L459L					VPS9 domain containing 1																		TGTACAGGGCCAGCAGCAGAG	0.627000													6	50					0.0215528	0.0219952	1	1	0
LMTK3	114783	broad.mit.edu	37	19	49013407	49013407	+	Silent	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr19:49013407C>T	ENST00000600059.1	-	3	461	c.234G>A	c.(232-234)gaG>gaA	p.E78E	LMTK3_ENST00000270238.3_Silent_p.E107E					lemur tyrosine kinase 3											breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(9)|prostate(1)	16		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		CGGAGCAGTCCTCCCCTTCAG	0.592000													3	21					0	0	1	0	0
EP300	2033	broad.mit.edu	37	22	41553245	41553245	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr22:41553245C>T	ENST00000263253.7	+	18	4553	c.3334C>T	c.(3334-3336)Cag>Tag	p.Q1112*		NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	1112	Bromo.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						TGGACAGTATCAGGAGCCCTG	0.398000			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				8	46					0	0	1	0	0
ATRN	8455	broad.mit.edu	37	20	3520912	3520912	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr20:3520912G>A	ENST00000262919.5	+	3	606	c.538G>A	c.(538-540)Gag>Aag	p.E180K	ATRN_ENST00000446916.2_Missense_Mutation_p.E180K	NM_139321.2	NP_647537.1	O75882	ATRN_HUMAN	attractin	180	CUB.				inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			breast(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(22)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	59						TTTTGCTACAGAGTGTAGTTG	0.333000													9	123					0	0	1	0	0
PDXDC2P	283970	broad.mit.edu	37	16	70010650	70010650	+	RNA	SNP	A	A	G	rs144900726	by1000genomes	TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr16:70010650A>G	ENST00000531894.1	-	0	3748					NR_003610.1																						AGGGCCGAAGAAGGGAATGTT	0.468000													3	70					0	0	1	0	0
ZNF33B	7582	broad.mit.edu	37	10	43089893	43089893	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr10:43089893C>T	ENST00000359467.3	-	5	619	c.505G>A	c.(505-507)Gaa>Aaa	p.E169K	ZNF33B_ENST00000486187.1_RNA	NM_006955.1	NP_008886.1	Q06732	ZN33B_HUMAN	zinc finger protein 33B	169						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.E169K(1)		breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(15)|skin(1)|stomach(1)	29						GCATTAAATTCGTCAGACTTT	0.328000													7	70					0	0	1	0	0
CHL1	10752	broad.mit.edu	37	3	432705	432705	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr3:432705G>C	ENST00000256509.2	+	22	3296	c.2654G>C	c.(2653-2655)aGa>aCa	p.R885T	CHL1_ENST00000397491.2_Missense_Mutation_p.R869T	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	869	Fibronectin type-III 3.				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		AACATTCTAAGATTTTCAGGA	0.358000													13	35					0	0	1	0	0
PDPR	55066	broad.mit.edu	37	16	70162999	70162999	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr16:70162999C>T	ENST00000288050.4	+	6	1538	c.581C>T	c.(580-582)gCc>gTc	p.A194V	PDPR_ENST00000568530.1_Missense_Mutation_p.A194V|PDPR_ENST00000398122.3_Missense_Mutation_p.A94V	NM_017990.3	NP_060460.4	Q8NCN5	PDPR_HUMAN	pyruvate dehydrogenase phosphatase regulatory subunit	194					glycine catabolic process|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	aminomethyltransferase activity|oxidoreductase activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|skin(2)|stomach(3)	33				BRCA - Breast invasive adenocarcinoma(221;0.124)		GTGGCTCTTGCCCTGGCAAGT	0.527000													4	141					0	0	1	0	0
KAT6A	7994	broad.mit.edu	37	8	41906066	41906066	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr8:41906066G>C	ENST00000396930.3	-	3	973	c.430C>G	c.(430-432)Cac>Gac	p.H144D	KAT6A_ENST00000485568.1_Missense_Mutation_p.H144D|KAT6A_ENST00000265713.2_Missense_Mutation_p.H144D|KAT6A_ENST00000406337.1_Missense_Mutation_p.H144D	NM_001099412.1	NP_001092882.1	Q92794	MYST3_HUMAN	K(lysine) acetyltransferase 6A	144	H15.|Required for activation of RUNX1-1.|Required for nuclear localization.				histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding										AACTGCTGGTGAAAGCCAGAG	0.483000													4	30					0	0	1	0	0
IL24	11009	broad.mit.edu	37	1	207076386	207076386	+	Silent	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr1:207076386G>A	ENST00000367093.3	+	6	721	c.447G>A	c.(445-447)caG>caA	p.Q149Q	IL24_ENST00000491169.1_3'UTR|IL24_ENST00000294984.2_Silent_p.Q201Q|IL24_ENST00000391929.3_Silent_p.Q202Q	NM_001185157.1|NM_001185158.1	NP_001172086.1|NP_001172087.1	Q13007	IL24_HUMAN	interleukin 24	201					apoptosis	extracellular space	cytokine activity			endometrium(4)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)	12	Breast(84;0.201)					CCTGGATGCAGAAATTCTACA	0.498000													11	94					0	0	1	0	0
ZFYVE26	23503	broad.mit.edu	37	14	68233027	68233027	+	Silent	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr14:68233027C>T	ENST00000347230.4	-	32	6066	c.5928G>A	c.(5926-5928)acG>acA	p.T1976T	ZFYVE26_ENST00000555452.1_Silent_p.T1976T	NM_015346.3	NP_056161.2	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	1976					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(8)|lung(39)|ovary(12)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	94				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		TCATGATGTCCGTGAGCAGCC	0.592000													13	46					0	0	1	0	0
RALBP1	10928	broad.mit.edu	37	18	9533819	9533819	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr18:9533819C>G	ENST00000019317.4	+	9	1919	c.1696C>G	c.(1696-1698)Ctg>Gtg	p.L566V	RALBP1_ENST00000383432.3_Missense_Mutation_p.L566V			Q15311	RBP1_HUMAN	ralA binding protein 1	566					chemotaxis|positive regulation of Cdc42 GTPase activity|small GTPase mediated signal transduction|transport	cytosol|membrane	ATPase activity, coupled to movement of substances|Rac GTPase activator activity|Rac GTPase binding|Ral GTPase binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(3)|upper_aerodigestive_tract(1)	14						GAACGAAGAGCTGGAAGTGAG	0.453000													4	60					0	0	1	0	0
LATS2	26524	broad.mit.edu	37	13	21620025	21620025	+	Silent	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr13:21620025C>T	ENST00000382592.4	-	2	546	c.141G>A	c.(139-141)ctG>ctA	p.L47L	LATS2_ENST00000542899.1_Silent_p.L47L	NM_014572.2	NP_055387.2	Q9NRM7	LATS2_HUMAN	large tumor suppressor kinase 2	47					cell division|G1/S transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|intracellular protein kinase cascade|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity	microtubule organizing center|nucleus|spindle pole	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(4)|central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(2)	45		all_cancers(29;4.74e-22)|all_epithelial(30;1.45e-18)|all_lung(29;4.69e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000781)|Epithelial(112;0.00144)|OV - Ovarian serous cystadenocarcinoma(117;0.0183)|Lung(94;0.0375)|LUSC - Lung squamous cell carcinoma(192;0.104)		CTTTGGCATCCAGGGAAGTGT	0.547000													17	41					0	0	1	0	0
KAT6A	7994	broad.mit.edu	37	8	41790682	41790682	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr8:41790682G>C	ENST00000396930.3	-	18	5599	c.5056C>G	c.(5056-5058)Cag>Gag	p.Q1686E	KAT6A_ENST00000265713.2_Missense_Mutation_p.Q1686E|KAT6A_ENST00000406337.1_Missense_Mutation_p.Q1686E	NM_001099412.1	NP_001092882.1	Q92794	MYST3_HUMAN	K(lysine) acetyltransferase 6A	1686	Gln/Pro-rich.				histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding										tgctggggctgaggctgcggc	0.652000													5	11					0	0	1	0	0
SYT3	84258	broad.mit.edu	37	19	51133423	51133423	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr19:51133423G>A	ENST00000338916.4	-	3	1313	c.680C>T	c.(679-681)cCa>cTa	p.P227L	SYT3_ENST00000544769.1_Missense_Mutation_p.P227L|SYT3_ENST00000593901.1_Missense_Mutation_p.P227L|SYT3_ENST00000600079.1_Missense_Mutation_p.P227L	NM_032298.2	NP_115674.1	Q9BQG1	SYT3_HUMAN	synaptotagmin III	227						cell junction|endosome|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|prostate(2)|skin(3)|urinary_tract(2)	35		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00462)|GBM - Glioblastoma multiforme(134;0.0188)		GGGCAGGGCTGGGTACCTGTA	0.672000													5	9					0	0	1	0	0
TRMT112	51504	broad.mit.edu	37	11	64084559	64084559	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr11:64084559G>C	ENST00000544844.1	-	3	798	c.241C>G	c.(241-243)Ctg>Gtg	p.L81V	TRMT112_ENST00000535750.1_Missense_Mutation_p.L37V|TRMT112_ENST00000308774.2_Missense_Mutation_p.L76V|TRMT112_ENST00000539854.1_Missense_Mutation_p.L81V|TRMT112_ENST00000535126.1_3'UTR			Q9UI30	TR112_HUMAN	tRNA methyltransferase 11-2 homolog (S. cerevisiae)	81	TRM112.				peptidyl-glutamine methylation	protein complex	protein binding|protein methyltransferase activity			large_intestine(1)|upper_aerodigestive_tract(1)	2						ATGGTCCTCAGAAACTCCTCA	0.597000													8	18					0	0	1	0	0
PDZD2	23037	broad.mit.edu	37	5	32093069	32093069	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr5:32093069C>A	ENST00000438447.1	+	21	8172	c.7784C>A	c.(7783-7785)tCg>tAg	p.S2595*	PDZD2_ENST00000282493.3_Nonsense_Mutation_p.S2595*			O15018	PDZD2_HUMAN	PDZ domain containing 2	2595					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						TCTGTTTTATCGTCAGTGGGA	0.388000													4	92					1	1	1	1	0
VPS9D1	9605	broad.mit.edu	37	16	89776195	89776195	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr16:89776195C>A	ENST00000561976.1	-	10	1545	c.1168G>T	c.(1168-1170)Gcc>Tcc	p.A390S	VPS9D1_ENST00000389386.3_Missense_Mutation_p.A460S					VPS9 domain containing 1																		CTGTACAGGGCCAGCAGCAGA	0.627000													6	46					0.0215528	0.0219952	1	1	0
ATR	545	broad.mit.edu	37	3	142185294	142185294	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr3:142185294C>T	ENST00000350721.4	-	40	6890	c.6769G>A	c.(6769-6771)Gaa>Aaa	p.E2257K	ATR_ENST00000383101.3_Missense_Mutation_p.E2193K|RP11-383G6.3_ENST00000460977.1_RNA	NM_001184.3	NP_001175.2	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related	2257					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			NS(1)|breast(10)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|liver(2)|lung(45)|ovary(3)|skin(10)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(4)	122						ATGAGGATTTCACTAAATGTT	0.383000								Other conserved DNA damage response genes					6	42					0	0	1	0	0
TUBGCP5	114791	broad.mit.edu	37	15	22851014	22851014	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr15:22851014G>C	ENST00000283645.4	+	11	1406	c.1276G>C	c.(1276-1278)Gat>Cat	p.D426H	TUBGCP5_ENST00000453949.2_Missense_Mutation_p.D426H|TUBGCP5_ENST00000559846.1_3'UTR	NM_052903.4	NP_443135.3	Q96RT8	GCP5_HUMAN	tubulin, gamma complex associated protein 5	426					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(5)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(23)|prostate(1)|skin(2)|urinary_tract(1)	46		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.86e-06)|Epithelial(43;2.63e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000949)		AGTTCCACCTGATACTCGAAA	0.468000													3	77					0	0	1	0	0
SERPINI2	5276	broad.mit.edu	37	3	167170773	167170773	+	Silent	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr3:167170773C>T	ENST00000476257.1	-	7	1213	c.915G>A	c.(913-915)ttG>ttA	p.L305L	SERPINI2_ENST00000264677.4_Silent_p.L305L|SERPINI2_ENST00000471111.1_Silent_p.L305L|SERPINI2_ENST00000461846.1_Silent_p.L305L			O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin), member 2	305					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(20)|prostate(1)|skin(5)|urinary_tract(1)	41						CGGTTATGTTCAAAGAATACA	0.279000													12	72					0	0	1	0	0
ENPEP	2028	broad.mit.edu	37	4	111397613	111397613	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr4:111397613C>G	ENST00000265162.5	+	1	385	c.43C>G	c.(43-45)Caa>Gaa	p.Q15E		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	15					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	ATACTGCATTCAAACGAAACA	0.453000													20	85					0	0	1	0	0
RGL3	57139	broad.mit.edu	37	19	11513144	11513144	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr19:11513144G>T	ENST00000380456.3	-	11	1379	c.1316C>A	c.(1315-1317)cCg>cAg	p.P439Q	RGL3_ENST00000393423.3_Missense_Mutation_p.P439Q	NM_001035223.2|NM_001161616.1	NP_001030300.2|NP_001155088.1	Q3MIN7	RGL3_HUMAN	ral guanine nucleotide dissociation stimulator-like 3	439	Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular				breast(1)|endometrium(4)|large_intestine(2)|lung(9)|ovary(1)|skin(1)	18						CAACATATCCGGCAGGGCTGT	0.602000													3	30					0.150653	0.151963	1	1	0
TMEM110	375346	broad.mit.edu	37	3	52878902	52878902	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr3:52878902G>C	ENST00000355083.5	-	5	628	c.483C>G	c.(481-483)atC>atG	p.I161M	TMEM110-MUSTN1_ENST00000504329.1_Missense_Mutation_p.I161M	NM_198563.2	NP_940965.1			transmembrane protein 110											kidney(1)|large_intestine(1)|lung(2)	4				BRCA - Breast invasive adenocarcinoma(193;7.72e-05)|Kidney(197;0.000777)|KIRC - Kidney renal clear cell carcinoma(197;0.000915)|OV - Ovarian serous cystadenocarcinoma(275;0.0541)		CAAAAATCATGATCACGATGT	0.547000													4	45					0	0	1	0	0
MAGI1	9223	broad.mit.edu	37	3	65342558	65342558	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr3:65342558C>T	ENST00000402939.2	-	23	3883	c.3884G>A	c.(3883-3885)cGa>cAa	p.R1295Q	MAGI1_ENST00000330909.8_3'UTR	NM_001033057.1	NP_001028229.1	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 1	1324					cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|liver(1)|lung(21)|pancreas(1)|skin(5)	51		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		GTCCTTGGGTCGGCATGCCCC	0.672000													6	41					0	0	1	0	0
MTSS1	9788	broad.mit.edu	37	8	125601934	125601934	+	Silent	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr8:125601934C>G	ENST00000518547.1	-	5	785	c.312G>C	c.(310-312)ctG>ctC	p.L104L	MTSS1_ENST00000325064.5_Silent_p.L104L|MTSS1_ENST00000378017.3_Silent_p.L104L|MTSS1_ENST00000354184.4_5'UTR	NM_001282971.1|NM_014751.4	NP_001269900.1|NP_055566.3	O43312	MTSS1_HUMAN	metastasis suppressor 1	104	IMD.				actin cytoskeleton organization|cell adhesion|cellular component movement|filopodium assembly|transmembrane receptor protein tyrosine kinase signaling pathway	actin cytoskeleton|endocytic vesicle|ruffle	actin monomer binding|cytoskeletal adaptor activity|receptor binding|SH3 domain binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	37	Ovarian(258;0.00438)|all_neural(195;0.00459)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			GTGGGTTTATCAGACAATCAA	0.423000													16	171					0	0	1	0	0
PNKP	11284	broad.mit.edu	37	19	50367478	50367478	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr19:50367478C>G	ENST00000322344.3	-	6	703	c.594G>C	c.(592-594)gaG>gaC	p.E198D	PNKP_ENST00000596014.1_Missense_Mutation_p.E198D|PNKP_ENST00000600573.1_Missense_Mutation_p.E198D|PNKP_ENST00000600910.1_Missense_Mutation_p.E198D	NM_007254.3	NP_009185.2	Q96T60	PNKP_HUMAN	polynucleotide kinase 3'-phosphatase	198					DNA damage response, detection of DNA damage|DNA-dependent DNA replication|nucleotide-excision repair, DNA damage removal|response to oxidative stress|response to radiation	nucleolus	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|damaged DNA binding|double-stranded DNA binding|endonuclease activity|nucleotide kinase activity|polynucleotide 3'-phosphatase activity|protein binding			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|urinary_tract(1)	19		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0118)|OV - Ovarian serous cystadenocarcinoma(262;0.0134)		TACGGGGAATCTCTGGGTACA	0.617000								Other BER factors					7	40					0	0	1	0	0
SLC39A2	29986	broad.mit.edu	37	14	21469393	21469393	+	Silent	SNP	C	C	T			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr14:21469393C>T	ENST00000298681.4	+	4	742	c.585C>T	c.(583-585)ctC>ctT	p.L195L	SLC39A2_ENST00000554422.1_3'UTR	NM_014579.3	NP_055394.2	Q9NP94	S39A2_HUMAN	solute carrier family 39 (zinc transporter), member 2	195						cytoplasmic membrane-bounded vesicle|integral to plasma membrane	zinc ion transmembrane transporter activity			breast(2)|central_nervous_system(1)|large_intestine(4)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	14	all_cancers(95;0.00267)		OV - Ovarian serous cystadenocarcinoma(11;1.34e-10)|Epithelial(56;1.57e-08)|all cancers(55;7.45e-08)	GBM - Glioblastoma multiforme(265;0.0187)		CCGTGCAGCTCTGCCTTGCTG	0.562000													4	49					0	0	1	0	0
EPHA7	2045	broad.mit.edu	37	6	94120421	94120421	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr6:94120421C>G	ENST00000369303.4	-	3	814	c.630G>C	c.(628-630)gaG>gaC	p.E210D	EPHA7_ENST00000369297.1_Missense_Mutation_p.E210D	NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	210	Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		TAGCTAAGTTCTCAATAATGG	0.438000													4	39					0	0	1	0	0
GPSM2	29899	broad.mit.edu	37	1	109466662	109466665	+	Frame_Shift_Del	DEL	TTTA	TTTA	-			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr1:109466662_109466665delTTTA	ENST00000406462.2	+	15	2414_2417	c.1641_1644delTTTA	c.(1639-1644)tttttafs	p.FL547fs	GPSM2_ENST00000264126.3_Frame_Shift_Del_p.FL547fs|AKNAD1_ENST00000357393.4_Intron			P81274	GPSM2_HUMAN	G-protein signaling modulator 2		GoLoco 2.				G-protein coupled receptor protein signaling pathway	cell cortex|nucleus	GTPase activator activity|identical protein binding			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|liver(2)|lung(3)	14		all_epithelial(167;7.64e-05)|all_lung(203;0.000321)|Lung NSC(277;0.000626)		Colorectal(144;0.0353)|Lung(183;0.0984)|COAD - Colon adenocarcinoma(174;0.129)|Epithelial(280;0.175)|all cancers(265;0.209)		CGGATGAGTTTTTAGATCTTCTTG	0.417													12	108	---	---	---	---					
KCNN2	3781	broad.mit.edu	37	5	113698631	113698632	+	In_Frame_Ins	INS	-	-	GCC	rs34838882	by1000genomes	TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr5:113698631_113698632insGCC	ENST00000512097.3	+	2	1177_1178	c.159_160insGCC	c.(160-162)gcc>GCCgcc	p.54_54A>AA	KCNN2_ENST00000264773.3_In_Frame_Ins_p.54_54A>AA			Q9H2S1	KCNN2_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2	54	Poly-Ala.					integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		CTGCAGCCGCTGCCGCCGCCGC	0.703													4	2	---	---	---	---					
RP11-493L12.5	0	broad.mit.edu	37	12	47761313	47761314	+	RNA	INS	-	-	T	rs57593482		TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr12:47761313_47761314insT	ENST00000550019.1	+	0	262																											ttcgctctctattttttttttt	0.406													4	7	---	---	---	---					
L3HYPDH	112849	broad.mit.edu	37	14	59950619	59950619	+	Frame_Shift_Del	DEL	C	C	-			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr14:59950619delC	ENST00000247194.4	-	1	529	c.416delG	c.(415-417)tgcfs	p.C139fs	RP11-701B16.2_ENST00000554253.1_RNA	NM_144581.1	NP_653182.1			L-3-hydroxyproline dehydratase (trans-)																		CACCAGCCCGCAGGGGCAGTG	0.716											OREG0022712	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	2	4	---	---	---	---					
UBR7	55148	broad.mit.edu	37	14	93681536	93681537	+	Frame_Shift_Ins	INS	-	-	C			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr14:93681536_93681537insC	ENST00000013070.6	+	6	746_747	c.510_511insC	c.(511-513)cccfs	p.P171fs	RP11-371E8.4_ENST00000557048.1_3'UTR|UBR7_ENST00000416753.1_Frame_Shift_Ins_p.P95fs	NM_175748.3	NP_786924.2	Q8N806	UBR7_HUMAN	ubiquitin protein ligase E3 component n-recognin 7 (putative)	171							ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(2)|large_intestine(2)|lung(12)|urinary_tract(1)	19						TTGGTGCCATTCCCCCTGAGAG	0.401													2	4	---	---	---	---					
SUPT6H	6830	broad.mit.edu	37	17	27027202	27027204	+	In_Frame_Del	DEL	AGC	AGC	-			TCGA-XF-A9SM-01A-11D-A42E-08	TCGA-XF-A9SM-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f0988ed-09a8-47ad-8a9a-3746506ee7d7	e289a5d3-7246-44ca-97a9-4d90f37c14a9	g.chr17:27027202_27027204delAGC	ENST00000314616.6	+	34	4856_4858	c.4573_4575delAGC	c.(4573-4575)agcdel	p.S1528del	SUPT6H_ENST00000347486.4_In_Frame_Del_p.S1528del	NM_003170.3	NP_003161.2	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog (S. cerevisiae)	1528	Poly-Ser.				chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	Lung NSC(42;0.00431)					CATCACCCCTAGCAGCAGCAGCA	0.537													8	135	---	---	---	---