Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
AQP11	282679	broad.mit.edu	37	11	77301521	77301521	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:77301521G>A	ENST00000313578.3	+	1	842	c.484G>A	c.(484-486)Gac>Aac	p.D162N	AQP11_ENST00000528638.1_Intron	NM_173039.2	NP_766627.1	Q8NBQ7	AQP11_HUMAN	aquaporin 11	162						cell surface|integral to membrane	transporter activity			kidney(2)|large_intestine(1)|lung(5)	8	all_cancers(14;1.75e-17)|all_epithelial(13;4.7e-20)|Ovarian(111;0.249)		Epithelial(5;4.73e-49)|BRCA - Breast invasive adenocarcinoma(5;1.4e-30)			CATCCGAGTCGACTTGCTCAA	0.567000													35	76					0	0	1	0	0
STX4	6810	broad.mit.edu	37	16	31051055	31051055	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:31051055G>C	ENST00000394998.1	+	11	1162	c.819G>C	c.(817-819)ttG>ttC	p.L273F	STX4_ENST00000493902.1_3'UTR|STX4_ENST00000313843.3_Missense_Mutation_p.L275F	NM_001272096.1	NP_001259025.1	Q12846	STX4_HUMAN	syntaxin 4	275	Interaction with CENPF (By similarity).				intracellular protein transport|platelet activation|post-Golgi vesicle-mediated transport	basolateral plasma membrane|cell surface|cytosol|integral to membrane|plasma membrane enriched fraction|specific granule|vacuole	SNAP receptor activity			NS(2)|breast(1)|large_intestine(3)|lung(3)	9						AGAAAGTCTTGATTGCCATCT	0.572000													80	181					0	0	1	0	0
PLEKHA8P1	51054	broad.mit.edu	37	12	45567959	45567959	+	RNA	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:45567959C>G	ENST00000256692.5	-	0	726					NR_037144.1															breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(10)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						TAGAGCAGCTCAGAGGTGAAG	0.443000													50	154					0	0	1	0	0
UPRT	139596	broad.mit.edu	37	X	74494400	74494400	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chrX:74494400G>A	ENST00000373379.1	+	1	476	c.311G>A	c.(310-312)cGg>cAg	p.R104Q	UPRT_ENST00000531704.1_3'UTR|UPRT_ENST00000373383.4_Missense_Mutation_p.R104Q			Q96BW1	UPP_HUMAN	uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae)	104					nucleoside metabolic process	cytoplasm|nucleus				breast(1)|endometrium(7)|kidney(2)|large_intestine(4)|lung(4)	18						GAACTCTCCCGGCAGATCGGG	0.562000													4	7					0	0	1	0	0
DDX42	11325	broad.mit.edu	37	17	61869830	61869830	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:61869830G>A	ENST00000578681.1	+	4	881	c.280G>A	c.(280-282)Gaa>Aaa	p.E94K	DDX42_ENST00000389924.2_Missense_Mutation_p.E94K|DDX42_ENST00000583590.1_Missense_Mutation_p.E94K|DDX42_ENST00000359353.5_5'UTR|DDX42_ENST00000457800.2_Missense_Mutation_p.E94K	NM_007372.2	NP_031398.2	Q86XP3	DDX42_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 42	94					protein localization|regulation of anti-apoptosis	Cajal body|cytoplasm|nuclear speck	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(3)	46						CATTCCTGCTGAAAACTCACC	0.418000													48	68					0	0	1	0	0
BLK	640	broad.mit.edu	37	8	11405588	11405588	+	Silent	SNP	C	C	A	rs149393791	byFrequency	TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:11405588C>A	ENST00000259089.4	+	4	815	c.223C>A	c.(223-225)Cgg>Agg	p.R75R	BLK_ENST00000529894.1_Silent_p.R4R	NM_001715.2	NP_001706.2	P51451	BLK_HUMAN	B lymphoid tyrosine kinase	75	SH3.				intracellular protein kinase cascade|positive regulation of insulin secretion		ATP binding|non-membrane spanning protein tyrosine kinase activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|skin(4)|stomach(1)	27			STAD - Stomach adenocarcinoma(15;0.00391)	COAD - Colon adenocarcinoma(149;0.207)		TATGAATGATCGGGACCTGCA	0.567000													21	33					5.26018e-13	5.62649e-13	1	1	0
MYH3	4621	broad.mit.edu	37	17	10542949	10542949	+	Silent	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:10542949G>C	ENST00000583535.1	-	23	2940	c.2853C>G	c.(2851-2853)ctC>ctG	p.L951L	MYH3_ENST00000226209.7_Silent_p.L951L	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	951					muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						TGTCTTTCTTGAGCTCTGAGC	0.478000													117	297					0	0	1	0	0
IMPDH1	3614	broad.mit.edu	37	7	128038653	128038653	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:128038653C>T	ENST00000338791.6	-	10	1239	c.889G>A	c.(889-891)Gtc>Atc	p.V297I	IMPDH1_ENST00000354269.5_Missense_Mutation_p.V287I|IMPDH1_ENST00000343214.4_Missense_Mutation_p.V187I|IMPDH1_ENST00000496200.1_Missense_Mutation_p.V187I|IMPDH1_ENST00000480861.1_Missense_Mutation_p.V207I|IMPDH1_ENST00000348127.6_Missense_Mutation_p.V261I|IMPDH1_ENST00000470772.1_Missense_Mutation_p.V211I|IMPDH1_ENST00000419067.2_Missense_Mutation_p.V264I|IMPDH1_ENST00000378717.4_Missense_Mutation_p.V228I	NM_000883.3	NP_000874.2	P20839	IMDH1_HUMAN	IMP (inosine 5'-monophosphate) dehydrogenase 1	212					GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	DNA binding|IMP dehydrogenase activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(3)	22					Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)|Ribavirin(DB00811)|Thioguanine(DB00352)	CAATCATTGACGATAGGCAGC	0.542000											OREG0018292	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	158					0	0	1	0	0
PPIL4	85313	broad.mit.edu	37	6	149867087	149867087	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:149867087C>T	ENST00000253329.2	-	1	87	c.55G>A	c.(55-57)Gaa>Aaa	p.E19K		NM_139126.3	NP_624311.1	Q8WUA2	PPIL4_HUMAN	peptidylprolyl isomerase (cyclophilin)-like 4	19	PPIase cyclophilin-type.				protein folding	nucleus	nucleotide binding|peptidyl-prolyl cis-trans isomerase activity|RNA binding			endometrium(2)|kidney(4)|large_intestine(1)|lung(4)|prostate(1)|urinary_tract(1)	13		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.11e-11)|GBM - Glioblastoma multiforme(68;0.0885)		GGCCGTTCTTCGGTGTACAAG	0.647000													5	9					0	0	1	0	0
RNGTT	8732	broad.mit.edu	37	6	89388140	89388140	+	Splice_Site	SNP	T	T	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:89388140T>C	ENST00000369485.4	-	14	1626		c.e14-2		RNGTT_ENST00000369475.3_Splice_Site|RNGTT_ENST00000265607.6_Splice_Site|RNGTT_ENST00000538899.1_Splice_Site	NM_003800.3	NP_003791.3	O60942	MCE1_HUMAN	RNA guanylyltransferase and 5'-phosphatase						interspecies interaction between organisms|mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	GTP binding|mRNA guanylyltransferase activity|polynucleotide 5'-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			endometrium(1)|large_intestine(7)|lung(6)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	21		all_cancers(76;4.07e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;6.86e-05)		BRCA - Breast invasive adenocarcinoma(108;0.151)		GGAAGTAACCTACAAAGAAAA	0.279000													22	31					0	0	1	0	0
SMCHD1	23347	broad.mit.edu	37	18	2732428	2732428	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr18:2732428C>G	ENST00000320876.6	+	25	3552	c.3214C>G	c.(3214-3216)Caa>Gaa	p.Q1072E	SMCHD1_ENST00000261598.8_Missense_Mutation_p.Q1072E|RP11-703M24.5_ENST00000583546.1_RNA	NM_015295.2	NP_056110.2	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible hinge domain containing 1	1072					chromosome organization		ATP binding			NS(3)|breast(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(16)|lung(15)|pancreas(1)	45						TCTTATTTTTCAAATGTATGA	0.303000													13	36					0	0	1	0	0
MEIS3	56917	broad.mit.edu	37	19	47910626	47910626	+	Silent	SNP	G	G	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:47910626G>T	ENST00000331559.5	-	9	1446	c.1005C>A	c.(1003-1005)atC>atA	p.I335I	MEIS3_ENST00000558555.1_Silent_p.I306I|MEIS3_ENST00000441740.2_Silent_p.I289I|MEIS3_ENST00000560253.1_5'UTR|MEIS3_ENST00000559524.1_Silent_p.I352I|MEIS3_ENST00000561293.1_Silent_p.I352I|MEIS3_ENST00000561096.1_Silent_p.I394I	NM_020160.2	NP_064545.1	Q99687	MEIS3_HUMAN	Meis homeobox 3	306						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|large_intestine(5)|lung(11)|prostate(1)|skin(2)	20		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;0.000198)|OV - Ovarian serous cystadenocarcinoma(262;0.000439)|Epithelial(262;0.0113)|GBM - Glioblastoma multiforme(486;0.0223)		TGACTTGCAGGATGGTGAGCC	0.716000													59	29					3.95532e-38	4.38972e-38	1	1	0
ULK3	25989	broad.mit.edu	37	15	75134485	75134485	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr15:75134485G>A	ENST00000440863.2	-	3	386	c.295C>T	c.(295-297)Ctg>Ttg	p.L99L	ULK3_ENST00000569437.1_Silent_p.L99L|ULK3_ENST00000568667.1_Silent_p.L110L	NM_001099436.1	NP_001092906	Q6PHR2	ULK3_HUMAN	unc-51 like kinase 3	99	Protein kinase.					cytoplasm	ATP binding|protein serine/threonine kinase activity			breast(2)	2						AAGCGAGACAGGTCGCCCCCT	0.547000													5	104					0	0	1	0	0
JARID2	3720	broad.mit.edu	37	6	15452374	15452374	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:15452374C>T	ENST00000341776.2	+	4	705	c.461C>T	c.(460-462)aCa>aTa	p.T154I	JARID2_ENST00000541660.1_Missense_Mutation_p.T116I|JARID2_ENST00000397311.3_5'UTR	NM_004973.3	NP_004964.2	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2	154					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	59	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				AAGCCTAAGACAGAAGATTTT	0.488000													31	74					0	0	1	0	0
SCAF1	58506	broad.mit.edu	37	19	50154733	50154733	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:50154733C>T	ENST00000360565.3	+	7	1211	c.1087C>T	c.(1087-1089)Cgg>Tgg	p.R363W		NM_021228.2	NP_067051.2	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	363					mRNA processing|RNA splicing	nucleus	RNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	20		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		AGAGGCTTGTCGGGAAGGCAA	0.721000													4	7					0	0	1	0	0
LYST	1130	broad.mit.edu	37	1	235969730	235969730	+	Silent	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:235969730G>C	ENST00000389794.3	-	6	2880	c.2706C>G	c.(2704-2706)ctC>ctG	p.L902L	LYST_ENST00000536965.1_Silent_p.L902L|LYST_ENST00000389793.2_Silent_p.L902L			Q99698	LYST_HUMAN	lysosomal trafficking regulator	902					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			AAGCCACACAGAGGAATAGGT	0.438000													68	187					0	0	1	0	0
NPIPB7	440350	broad.mit.edu	37	16	28468167	28468167	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:28468167G>T	ENST00000452313.1	-	7	931	c.823C>A	c.(823-825)Cca>Aca	p.P275T																								ACTGAGGGTGGAAGGGGAGTG	0.517000													26	77					6.03168e-27	6.61762e-27	1	1	0
CYP39A1	51302	broad.mit.edu	37	6	46620303	46620303	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:46620303G>T	ENST00000275016.2	-	1	220	c.17C>A	c.(16-18)cCa>cAa	p.P6Q		NM_016593.3	NP_057677.2	Q9NYL5	CP39A_HUMAN	cytochrome P450, family 39, subfamily A, polypeptide 1	6					bile acid biosynthetic process|bile acid catabolic process|digestion|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	24-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity		EIF3K/CYP39A1(2)	NS(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(2)|skin(2)	21						AATCACTGTTGGGGAAATTAG	0.483000													88	264					5.42381e-49	6.08989e-49	1	1	0
IL23R	149233	broad.mit.edu	37	1	67666436	67666436	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:67666436G>A	ENST00000347310.5	+	5	679	c.508G>A	c.(508-510)Gag>Aag	p.E170K	C1orf141_ENST00000371007.2_Intron|IL23R_ENST00000371002.1_Missense_Mutation_p.E170K	NM_144701.2	NP_653302.2	Q5VWK5	IL23R_HUMAN	interleukin 23 receptor	170	Fibronectin type-III 1.				inflammatory response|negative regulation of interleukin-10 production|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of interleukin-12 production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|response to interferon-gamma|response to lipopolysaccharide	interleukin-23 receptor complex	receptor activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	21						GACAGAAGAAGAGCAACAGTA	0.383000													54	29					0	0	1	0	0
P2RX5-TAX1BP3	100533970	broad.mit.edu	37	17	3593444	3593444	+	Splice_Site	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:3593444C>T	ENST00000550383.1	-	6	722	c.534G>A	c.(532-534)gaG>gaA	p.E178E	P2RX5_ENST00000550772.1_5'UTR|P2RX5_ENST00000225328.5_Splice_Site_p.E178E|P2RX5_ENST00000551178.1_Splice_Site_p.E154E|P2RX5_ENST00000435558.1_Splice_Site_p.E178E|P2RX5_ENST00000552276.1_Splice_Site_p.E178E|P2RX5_ENST00000552050.1_Splice_Site_p.E118E|P2RX5_ENST00000547178.1_Splice_Site_p.E178E|P2RX5_ENST00000345901.3_Splice_Site_p.E154E																							GGAATGGCTCCCTGAAAACCA	0.577000													50	190					0	0	1	0	0
C9orf156	51531	broad.mit.edu	37	9	100667150	100667150	+	Missense_Mutation	SNP	G	G	C	rs34857285		TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr9:100667150G>C	ENST00000375119.3	-	5	1267	c.1191C>G	c.(1189-1191)ttC>ttG	p.F397L		NM_016481.3	NP_057565.3	Q9BU70	NAP1_HUMAN	chromosome 9 open reading frame 156	397					interspecies interaction between organisms		hydrolase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(3)|prostate(1)|skin(1)	13		Acute lymphoblastic leukemia(62;0.158)				CAGTAAAGTAGAAAAGGCGGT	0.527000													72	76					0	0	1	0	0
ZNF534	147658	broad.mit.edu	37	19	52942471	52942471	+	Silent	SNP	C	C	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:52942471C>A	ENST00000332323.6	+	4	1858	c.1797C>A	c.(1795-1797)gtC>gtA	p.V599V	ZNF534_ENST00000301085.4_Intron|ZNF534_ENST00000433050.1_Silent_p.V586V|ZNF534_ENST00000432303.2_Intron	NM_001143939.1	NP_001137411.1	Q76KX8	ZN534_HUMAN	zinc finger protein 534	599					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|lung(1)|prostate(1)|skin(1)	4						GTGGCAAGGTCTTCAGTCGGA	0.433000													5	11					1	1	1	1	0
XIRP2	129446	broad.mit.edu	37	2	168100730	168100730	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr2:168100730G>C	ENST00000409195.1	+	9	2917	c.2828G>C	c.(2827-2829)gGa>gCa	p.G943A	XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.G721A|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.G943A	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	768					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GTTGACAGAGGAGATGTGAAG	0.343000													32	36					0	0	1	0	0
CAMSAP3	57662	broad.mit.edu	37	19	7682676	7682676	+	Silent	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:7682676C>G	ENST00000446248.2	+	19	3665	c.3564C>G	c.(3562-3564)ctC>ctG	p.L1188L	CAMSAP3_ENST00000160298.4_Silent_p.L1161L	NM_001080429.2	NP_001073898.1	Q9P1Y5	CAMP3_HUMAN	calmodulin regulated spectrin-associated protein family, member 3	1161	CKK.				epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			cervix(1)|endometrium(7)|kidney(3)|lung(6)|urinary_tract(2)	19						TCCTGATCCTCTTTCGCGACT	0.637000													19	40					0	0	1	0	0
ARHGAP31	57514	broad.mit.edu	37	3	119134233	119134233	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr3:119134233G>C	ENST00000264245.4	+	12	3989	c.3457G>C	c.(3457-3459)Gac>Cac	p.D1153H		NM_020754.2	NP_065805.2	Q2M1Z3	RHG31_HUMAN	Rho GTPase activating protein 31	1153					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(3)|large_intestine(11)|lung(29)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	67						CTGTAAAGCAGACCCCTGGAG	0.537000													14	63					0	0	1	0	0
SMAD9	4093	broad.mit.edu	37	13	37439763	37439763	+	Nonsense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr13:37439763G>C	ENST00000379826.4	-	5	1256	c.914C>G	c.(913-915)tCa>tGa	p.S305*	SMAD9_ENST00000350148.5_Nonsense_Mutation_p.S268*|SMAD9_ENST00000399275.2_Nonsense_Mutation_p.S305*	NM_001127217.2	NP_001120689.1	O15198	SMAD9_HUMAN	SMAD family member 9	305	MH2.				BMP signaling pathway|transforming growth factor beta receptor signaling pathway	cytosol|transcription factor complex	sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity			NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)	18		Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)		all cancers(112;3.38e-07)|Epithelial(112;1.93e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00804)|BRCA - Breast invasive adenocarcinoma(63;0.0129)|GBM - Glioblastoma multiforme(144;0.026)		CCTGTTATTTGAAGGGTCGGT	0.453000													23	45					0	0	1	0	0
NKTR	4820	broad.mit.edu	37	3	42679721	42679721	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr3:42679721G>C	ENST00000232978.8	+	13	2713	c.2525G>C	c.(2524-2526)aGa>aCa	p.R842T	RP4-613B23.1_ENST00000434363.1_RNA|RP4-613B23.1_ENST00000438017.1_RNA|RP4-613B23.1_ENST00000445452.1_RNA	NM_005385.3	NP_005376.2	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	842					protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	41				KIRC - Kidney renal clear cell carcinoma(284;0.24)		GAAAAAAACAGAGGTGAAGAA	0.413000													14	50					0	0	1	0	0
KARS	3735	broad.mit.edu	37	16	75670391	75670391	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:75670391C>T	ENST00000319410.5	-	5	648	c.527G>A	c.(526-528)cGa>cAa	p.R176Q	KARS_ENST00000302445.3_Missense_Mutation_p.R148Q|KARS_ENST00000568378.1_Intron	NM_001130089.1	NP_001123561.1	Q15046	SYK_HUMAN	lysyl-tRNA synthetase	148					interspecies interaction between organisms|lysyl-tRNA aminoacylation|tRNA processing	cytosol|extracellular region|mitochondrial matrix|nucleus|plasma membrane|soluble fraction	ATP binding|lysine-tRNA ligase activity|metal ion binding|tRNA binding			kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	18					L-Lysine(DB00123)	CCCCTCTCCTCGAAGATCATA	0.453000													38	223					0	0	1	0	0
ZC3H18	124245	broad.mit.edu	37	16	88644047	88644047	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:88644047G>C	ENST00000301011.5	+	2	716	c.516G>C	c.(514-516)caG>caC	p.Q172H	ZC3H18_ENST00000452588.2_Missense_Mutation_p.Q172H	NM_144604.3	NP_653205.3	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	172						nucleus	nucleic acid binding|zinc ion binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(9)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	42				BRCA - Breast invasive adenocarcinoma(80;0.0542)		CTGGTGTTCAGAGTGTGGGAG	0.557000													7	60					0	0	1	0	0
MYO18A	399687	broad.mit.edu	37	17	27447636	27447636	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:27447636G>C	ENST00000527372.1	-	7	1906	c.1726C>G	c.(1726-1728)Cag>Gag	p.Q576E	MYO18A_ENST00000531253.1_Missense_Mutation_p.Q576E|MYO18A_ENST00000354329.4_Missense_Mutation_p.Q576E|MYO18A_ENST00000533112.1_Missense_Mutation_p.Q576E	NM_078471.3	NP_510880.2	Q92614	MY18A_HUMAN	myosin XVIIIA	576	Myosin head-like.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity			NS(1)|cervix(1)|endometrium(6)|kidney(6)|lung(20)|urinary_tract(2)	36			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			ACTCTCACCTGAATGGAGGCT	0.562000													16	26					0	0	1	0	0
POLD2	5425	broad.mit.edu	37	7	44156568	44156568	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:44156568C>T	ENST00000406581.2	-	7	1277	c.628G>A	c.(628-630)Gag>Aag	p.E210K	POLD2_ENST00000223361.3_Missense_Mutation_p.E210K|POLD2_ENST00000452185.1_Missense_Mutation_p.E210K	NM_001256879.1	NP_001243808.1	P49005	DPOD2_HUMAN	polymerase (DNA directed), delta 2, accessory subunit	210					base-excision repair|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	DNA binding|DNA-directed DNA polymerase activity|protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|skin(1)|urinary_tract(1)	12						AGCAGGCTCTCGCCTCCACCG	0.692000													12	20					0	0	1	0	0
N6AMT2	221143	broad.mit.edu	37	13	21331724	21331724	+	Missense_Mutation	SNP	T	T	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr13:21331724T>A	ENST00000382758.1	-	2	61	c.14A>T	c.(13-15)gAa>gTa	p.E5V	N6AMT2_ENST00000382754.4_Missense_Mutation_p.E5V|N6AMT2_ENST00000460374.1_5'UTR			Q8WVE0	N6MT2_HUMAN	N-6 adenine-specific DNA methyltransferase 2 (putative)	5							methyltransferase activity|nucleic acid binding			endometrium(1)|large_intestine(3)|lung(3)	7		all_cancers(29;5.91e-19)|all_epithelial(30;1.42e-15)|all_lung(29;5.9e-14)|Lung SC(185;0.0367)		all cancers(112;0.000234)|Epithelial(112;0.000471)|OV - Ovarian serous cystadenocarcinoma(117;0.0111)|Lung(94;0.0161)|LUSC - Lung squamous cell carcinoma(192;0.0431)		CTCATCATCTTCCAAATCACT	0.403000													11	79					0	0	1	0	0
UBE2B	7320	broad.mit.edu	37	5	133724024	133724024	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:133724024G>T	ENST00000265339.2	+	5	667	c.250G>T	c.(250-252)Gat>Tat	p.D84Y	UBE2B_ENST00000511807.1_Intron	NM_003337.2	NP_003328.1	P63146	UBE2B_HUMAN	ubiquitin-conjugating enzyme E2B	84					canonical Wnt receptor signaling pathway|histone H2A ubiquitination|negative regulation of cAMP-mediated signaling|postreplication repair|proteasomal ubiquitin-dependent protein catabolic process|protein autoubiquitination|protein K11-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein stabilization|response to drug|response to UV	cytoplasm|plasma membrane|replication fork	ATP binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity			kidney(1)|large_intestine(2)|lung(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AGTGTATGCTGATGGTAGCAT	0.348000								Rad6 pathway					20	44					4.96729e-08	5.18326e-08	1	1	0
GRIK1	2897	broad.mit.edu	37	21	31062135	31062135	+	Missense_Mutation	SNP	C	C	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr21:31062135C>A	ENST00000399914.1	-	3	978	c.457G>T	c.(457-459)Gat>Tat	p.D153Y	GRIK1_ENST00000399913.1_Missense_Mutation_p.D153Y|GRIK1_ENST00000389125.3_Missense_Mutation_p.D153Y|GRIK1_ENST00000389124.2_Missense_Mutation_p.D153Y|GRIK1_ENST00000399909.1_Missense_Mutation_p.D153Y|GRIK1_ENST00000309434.7_Missense_Mutation_p.D153Y|GRIK1_ENST00000535441.1_Missense_Mutation_p.D153Y|GRIK1_ENST00000327783.4_Missense_Mutation_p.D153Y|GRIK1_ENST00000472429.1_5'UTR|GRIK1_ENST00000399907.1_Missense_Mutation_p.D153Y			P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	153					central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(18)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	45					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	GCTGCATAATCTGGGTAAAGG	0.473000													90	140					3.90494e-43	4.35901e-43	1	1	0
TACC1	6867	broad.mit.edu	37	8	38677879	38677879	+	Nonsense_Mutation	SNP	C	C	T	rs149014810	by1000genomes	TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:38677879C>T	ENST00000379931.3	+	3	1496	c.1117C>T	c.(1117-1119)Cga>Tga	p.R373*	TACC1_ENST00000348567.4_Intron|TACC1_ENST00000520615.1_Nonsense_Mutation_p.R178*|TACC1_ENST00000443286.2_Nonsense_Mutation_p.R389*|TACC1_ENST00000518415.1_Nonsense_Mutation_p.R328*|TACC1_ENST00000520973.1_Nonsense_Mutation_p.R178*|TACC1_ENST00000522752.1_Intron|TACC1_ENST00000520340.1_Nonsense_Mutation_p.R337*|TACC1_ENST00000276520.8_Intron|TACC1_ENST00000317827.4_Nonsense_Mutation_p.R373*|TACC1_ENST00000519416.1_Nonsense_Mutation_p.R178*|TACC1_ENST00000330691.6_Intron			O75410	TACC1_HUMAN	transforming, acidic coiled-coil containing protein 1	373	Interaction with YEATS4.|SPAZ 2.				cell cycle|cell division	intermediate filament cytoskeleton|microtubule organizing center|nucleus	protein binding			breast(4)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|skin(3)	17		all_lung(54;0.00292)|Lung NSC(58;0.0115)|Hepatocellular(245;0.065)	LUSC - Lung squamous cell carcinoma(45;1.7e-09)|COAD - Colon adenocarcinoma(9;0.235)			CCCAGTGGCACGAGACGGGCC	0.527000													32	205					0	0	1	0	0
LSP1	4046	broad.mit.edu	37	11	1905742	1905742	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:1905742G>C	ENST00000406638.2	+	7	1764	c.462G>C	c.(460-462)aaG>aaC	p.K154N	LSP1_ENST00000381775.1_Missense_Mutation_p.K344N|LSP1_ENST00000485341.1_3'UTR|LSP1_ENST00000405957.2_Missense_Mutation_p.K154N|LSP1_ENST00000311604.3_Missense_Mutation_p.K216N	NM_001013254.1|NM_001013255.1	NP_001013272.1|NP_001013273.1	P33241	LSP1_HUMAN	lymphocyte-specific protein 1	216					cellular component movement|cellular defense response	actin cytoskeleton|Golgi apparatus|plasma membrane	actin binding|signal transducer activity			haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(9)|prostate(1)|skin(1)	16		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|Lung(200;0.0729)|LUSC - Lung squamous cell carcinoma(625;0.0856)		ACAGTGTGAAGAAATCCCAGC	0.572000													14	43					0	0	1	0	0
BAZ1B	9031	broad.mit.edu	37	7	72892759	72892759	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:72892759C>T	ENST00000339594.4	-	7	1370	c.1032G>A	c.(1030-1032)aaG>aaA	p.K344K	BAZ1B_ENST00000404251.1_Silent_p.K344K	NM_032408.3	NP_115784.1	Q9UIG0	BAZ1B_HUMAN	bromodomain adjacent to zinc finger domain, 1B	344	Lys-rich.|Mediates the tyrosine-protein kinase activity.				ATP-dependent chromatin remodeling|chromatin-mediated maintenance of transcription|DNA replication-dependent nucleosome disassembly|double-strand break repair|heart morphogenesis|transcription, DNA-dependent	WINAC complex	ATP binding|chromatin binding|histone acetyl-lysine binding|histone kinase activity|non-membrane spanning protein tyrosine kinase activity|protein complex scaffold|vitamin D receptor activator activity|vitamin D receptor binding|zinc ion binding			NS(1)|breast(5)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(12)|lung(20)|ovary(5)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Lung NSC(55;0.0659)|all_lung(88;0.152)				CACTCAATGACTTCTTCAAGT	0.423000													30	78					0	0	1	0	0
RUNX1	861	broad.mit.edu	37	21	36206817	36206817	+	Missense_Mutation	SNP	C	C	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr21:36206817C>A	ENST00000344691.4	-	4	2191	c.614G>T	c.(613-615)cGg>cTg	p.R205L	RUNX1_ENST00000399240.1_Intron|RUNX1_ENST00000358356.5_Missense_Mutation_p.R205L|RUNX1_ENST00000300305.3_Missense_Mutation_p.R232L|RUNX1_ENST00000325074.5_Missense_Mutation_p.R220L|RUNX1_ENST00000437180.1_Missense_Mutation_p.R232L	NM_001001890.2	NP_001001890.1	Q01196	RUNX1_HUMAN	runt-related transcription factor 1	205	Pro/Ser/Thr-rich.				myeloid cell differentiation|negative regulation of granulocyte differentiation|positive regulation of angiogenesis|positive regulation of granulocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|calcium ion binding|DNA binding|protein binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding	p.R232L(1)		breast(5)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(428)|large_intestine(3)|lung(6)|oesophagus(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	452						GGCTGTGCGCCGCAGCTGCTC	0.612000			T	"""RPL22, MDS1, EVI1, CBFA2T3, CBFA2T1, ETV6, LAF4"""	"""AML, preB- ALL, T-ALL"""								59	45					7.73544e-29	8.51121e-29	1	1	0
MLLT10	8028	broad.mit.edu	37	10	21962602	21962602	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:21962602G>A	ENST00000377072.3	+	11	1723	c.1375G>A	c.(1375-1377)Gaa>Aaa	p.E459K	MLLT10_ENST00000377059.3_Missense_Mutation_p.E459K|MLLT10_ENST00000446906.2_Missense_Mutation_p.E459K|MLLT10_ENST00000307729.7_Missense_Mutation_p.E459K	NM_004641.3	NP_004632.1	P55197	AF10_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10	459	DNA-binding.				positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	6						TTCTGGCATAGAAGAAGAAAC	0.398000			T	"""MLL, PICALM, CDK6"""	AL								86	200					0	0	1	0	0
POC5	134359	broad.mit.edu	37	5	74970365	74970365	+	Silent	SNP	C	C	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:74970365C>A	ENST00000428202.2	-	12	1812	c.1623G>T	c.(1621-1623)cgG>cgT	p.R541R	POC5_ENST00000514838.2_Silent_p.R513R|POC5_ENST00000510798.1_Silent_p.R365R|POC5_ENST00000380475.2_Silent_p.R365R|POC5_ENST00000446329.2_Silent_p.R516R	NM_001099271.1	NP_001092741.1	Q8NA72	POC5_HUMAN	POC5 centriolar protein	541					cell cycle	centriole				breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						GATGAATGGTCCGGGGATATT	0.398000													92	79					8.92586e-32	9.87761e-32	1	1	0
C12orf71	728858	broad.mit.edu	37	12	27235288	27235288	+	Silent	SNP	A	A	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:27235288A>G	ENST00000429849.2	-	1	159	c.129T>C	c.(127-129)gaT>gaC	p.D43D		NM_001080406.1	NP_001073875.1	A8MTZ7	CL071_HUMAN	chromosome 12 open reading frame 71	43										endometrium(2)|large_intestine(1)|lung(4)|skin(1)	8						TGGAAGGTGCATCTTCCCAGG	0.547000													9	43					0	0	1	0	0
CDT1	81620	broad.mit.edu	37	16	88870299	88870299	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:88870299C>G	ENST00000301019.4	+	1	679	c.60C>G	c.(58-60)atC>atG	p.I20M		NM_030928.3	NP_112190.2	Q9H211	CDT1_HUMAN	chromatin licensing and DNA replication factor 1	20					DNA replication|DNA replication checkpoint|M/G1 transition of mitotic cell cycle|regulation of DNA-dependent DNA replication initiation|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nucleoplasm	DNA binding|protein binding			central_nervous_system(1)|endometrium(2)|kidney(1)|lung(3)	7				BRCA - Breast invasive adenocarcinoma(80;0.0476)		ccccccgcATCGCGCCGCCCA	0.781000													2	7					0	0	1	0	0
INPP5D	3635	broad.mit.edu	37	2	234079249	234079249	+	Splice_Site	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr2:234079249C>T	ENST00000359570.5	+	18	1863	c.1863C>T	c.(1861-1863)ttC>ttT	p.F621F	INPP5D_ENST00000538935.1_3'UTR|INPP5D_ENST00000450745.1_Splice_Site_p.F385F|INPP5D_ENST00000455936.2_Splice_Site_p.F385F			Q92835	SHIP1_HUMAN	inositol polyphosphate-5-phosphatase, 145kDa	633					apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			central_nervous_system(1)|ovary(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		TCCTACACTTCGGTAAGAGCA	0.577000													16	18					0	0	1	0	0
ZFP36L2	678	broad.mit.edu	37	2	43452168	43452168	+	Missense_Mutation	SNP	T	T	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr2:43452168T>C	ENST00000282388.3	-	2	1068	c.775A>G	c.(775-777)Agc>Ggc	p.S259G	THADA_ENST00000330266.7_Intron	NM_006887.4	NP_008818.3	P47974	TISD_HUMAN	ZFP36 ring finger protein-like 2	259					cell proliferation	nucleus	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	15		Acute lymphoblastic leukemia(82;0.00323)|all_hematologic(82;0.00824)				CCCGAGAAGCTGAGGCTGTGG	0.756000													7	12					0	0	1	0	0
EYS	346007	broad.mit.edu	37	6	66044988	66044988	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:66044988G>A	ENST00000503581.1	-	11	2188	c.1651C>T	c.(1651-1653)Cgg>Tgg	p.R551W	EYS_ENST00000393380.2_Missense_Mutation_p.R551W|EYS_ENST00000370616.2_Missense_Mutation_p.R551W|EYS_ENST00000370618.3_Missense_Mutation_p.R551W|EYS_ENST00000342421.5_Missense_Mutation_p.R551W|EYS_ENST00000370621.3_Missense_Mutation_p.R551W	NM_001142800.1	NP_001136272.1	Q5T1H1	EYS_HUMAN	eyes shut homolog (Drosophila)	551			R -> L.		response to stimulus|visual perception	extracellular region	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	69						CATAGATACCGATATTCCTGA	0.358000													15	98					0	0	1	0	0
GIF	2694	broad.mit.edu	37	11	59609985	59609985	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:59609985C>G	ENST00000541311.1	-	4	601	c.367G>C	c.(367-369)Gag>Cag	p.E123Q	GIF_ENST00000257248.2_Missense_Mutation_p.E148Q			P27352	IF_HUMAN	gastric intrinsic factor (vitamin B synthesis)	148					cobalamin metabolic process|cobalamin transport|cobalt ion transport	apical plasma membrane|endosome|extracellular space|microvillus	cobalamin binding			large_intestine(4)|liver(1)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	17						AAGGTCGCCTCAGAGTTCTTC	0.577000													22	61					0	0	1	0	0
NANOS2	339345	broad.mit.edu	37	19	46417599	46417599	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:46417599C>T	ENST00000341294.2	-	1	437	c.353G>A	c.(352-354)gGt>gAt	p.G118D		NM_001029861.2	NP_001025032.1	P60321	NANO2_HUMAN	nanos homolog 2 (Drosophila)	118					germ-line stem cell maintenance|mRNA catabolic process|multicellular organismal development|negative regulation of meiosis|regulation of translation|spermatogenesis	cytoplasmic mRNA processing body|perinuclear region of cytoplasm	RNA binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)	6		Ovarian(192;0.0308)|all_neural(266;0.0476)		OV - Ovarian serous cystadenocarcinoma(262;0.00442)|GBM - Glioblastoma multiforme(486;0.0668)|Epithelial(262;0.231)		CTGCTGGCCACCGTTAAGCGG	0.672000													21	23					0	0	1	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103049829	103049829	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:103049829G>T	ENST00000375735.2	+	39	6358	c.6214G>T	c.(6214-6216)Gat>Tat	p.D2072Y	DYNC2H1_ENST00000334267.7_Intron|DYNC2H1_ENST00000398093.3_Missense_Mutation_p.D2072Y	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	2072	AAA 2 (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		TGTTCTGGATGATAATCGACT	0.388000													12	44					5.50884e-06	5.6713e-06	1	1	0
VPS53	55275	broad.mit.edu	37	17	556596	556596	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:556596C>T	ENST00000437048.2	-	7	689	c.543G>A	c.(541-543)gtG>gtA	p.V181V	VPS53_ENST00000574029.1_Intron|VPS53_ENST00000291074.5_Silent_p.V152V|VPS53_ENST00000576149.1_Intron|VPS53_ENST00000571805.1_Silent_p.V181V|VPS53_ENST00000401468.3_Intron|VPS53_ENST00000446250.2_5'UTR	NM_001128159.2	NP_001121631.1	Q5VIR6	VPS53_HUMAN	vacuolar protein sorting 53 homolog (S. cerevisiae)	181					protein transport	endosome membrane|Golgi apparatus				breast(1)|endometrium(4)|large_intestine(5)|lung(8)|prostate(1)	19				UCEC - Uterine corpus endometrioid carcinoma (25;0.0265)		GGACATTCATCACACCCTGAA	0.448000													23	265					0	0	1	0	0
ILF3	3609	broad.mit.edu	37	19	10793282	10793282	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:10793282G>A	ENST00000449870.1	+	13	1767	c.1450G>A	c.(1450-1452)Gag>Aag	p.E484K	ILF3_ENST00000592763.1_Missense_Mutation_p.E484K|ILF3_ENST00000407004.3_Missense_Mutation_p.E484K|ILF3_ENST00000250241.8_Missense_Mutation_p.E484K|ILF3_ENST00000588657.1_Missense_Mutation_p.E484K|ILF3_ENST00000589998.1_Missense_Mutation_p.E484K|ILF3_ENST00000318511.3_Missense_Mutation_p.E484K|ILF3_ENST00000420083.1_Missense_Mutation_p.E484K|ILF3_ENST00000590261.1_Missense_Mutation_p.E484K	NM_017620.2	NP_060090.2	Q12906	ILF3_HUMAN	interleukin enhancer binding factor 3, 90kDa	484					M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|ovary(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)			GGACTCGGCTGAGGAGACCGA	0.647000													9	33					0	0	1	0	0
EXD3	54932	broad.mit.edu	37	9	140250821	140250821	+	Splice_Site	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr9:140250821C>G	ENST00000340951.4	-	8	852		c.e8-1		EXD3_ENST00000342129.4_Splice_Site	NM_017820.3	NP_060290.3	Q8N9H8	MUT7_HUMAN	exonuclease 3'-5' domain containing 3						nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(2)	12						AGGGTACCGTCTGTGGGGAGA	0.502000													6	8					0	0	1	0	0
RBCK1	10616	broad.mit.edu	37	20	391100	391100	+	Nonsense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr20:391100C>G	ENST00000475269.1	+	3	892	c.212C>G	c.(211-213)tCa>tGa	p.S71*	RBCK1_ENST00000400245.3_3'UTR|RBCK1_ENST00000400247.3_Nonsense_Mutation_p.S29*|RBCK1_ENST00000353660.3_Intron|RBCK1_ENST00000356286.5_Intron|RBCK1_ENST00000382181.2_Intron			Q9BYM8	HOIL1_HUMAN	RanBP-type and C3HC4-type zinc finger containing 1	141	Interaction with IRF3.|Interaction with RNF31.|Interaction with TAB2.|Ubiquitin-like.				interspecies interaction between organisms|negative regulation of NF-kappaB transcription factor activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|proteasomal ubiquitin-dependent protein catabolic process|protein linear polyubiquitination|T cell receptor signaling pathway	LUBAC complex	protein binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(1)|lung(4)	5		all_epithelial(17;0.172)|Lung NSC(37;0.191)|Breast(17;0.231)				atccagccatcacatcacagg	0.473000													10	38					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10415489	10415489	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:10415489G>C	ENST00000226207.5	-	13	1262	c.1168C>G	c.(1168-1170)Ctc>Gtc	p.L390V	CTC-297N7.11_ENST00000587182.2_RNA|RP11-799N11.1_ENST00000399342.2_RNA|RP11-799N11.1_ENST00000581304.1_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	390	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						AGATTTTGGAGATAGGCTGCC	0.453000													238	219					0	0	1	0	0
SEMA3C	10512	broad.mit.edu	37	7	80418743	80418743	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:80418743G>C	ENST00000265361.3	-	12	1794	c.1233C>G	c.(1231-1233)atC>atG	p.I411M	SEMA3C_ENST00000544525.1_Missense_Mutation_p.I429M|SEMA3C_ENST00000419255.2_Missense_Mutation_p.I411M	NM_006379.3	NP_006370.1	Q99985	SEM3C_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	411	Sema.				immune response|response to drug	membrane	receptor activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						GGATTGGGTAGATGGAATTGT	0.453000													47	56					0	0	1	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33614470	33614470	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:33614470C>G	ENST00000504830.1	-	16	2735	c.2400G>C	c.(2398-2400)caG>caC	p.Q800H	ADAMTS12_ENST00000352040.3_Missense_Mutation_p.Q715H|ADAMTS12_ENST00000504582.1_5'UTR	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	800	Spacer 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.Q800H(1)		NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						GGTTAGTCACCTGGAATAGAA	0.438000										HNSCC(64;0.19)			6	90					0	0	1	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232574863	232574863	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:232574863G>C	ENST00000366630.1	-	14	4380	c.4022C>G	c.(4021-4023)tCt>tGt	p.S1341C	SIPA1L2_ENST00000262861.4_Missense_Mutation_p.S1341C|SIPA1L2_ENST00000308942.4_Missense_Mutation_p.S415C			Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like 2	1341	Ser-rich.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				CCTGGAATGAGAGGATATCTC	0.582000													19	76					0	0	1	0	0
SH2D2A	9047	broad.mit.edu	37	1	156777073	156777073	+	Missense_Mutation	SNP	T	T	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:156777073T>G	ENST00000392306.2	-	8	1236	c.1097A>C	c.(1096-1098)cAc>cCc	p.H366P	SH2D2A_ENST00000368199.3_Missense_Mutation_p.H356P|SH2D2A_ENST00000368198.3_Missense_Mutation_p.H338P	NM_001161441.1	NP_001154913.1	Q9NP31	SH22A_HUMAN	SH2 domain containing 2A	356	Pro-rich.				angiogenesis|cell differentiation|signal transduction	cytoplasm|soluble fraction	SH3 domain binding|SH3/SH2 adaptor activity			endometrium(1)|large_intestine(2)|lung(15)	18	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TGGGGGCTGGTGGGGCAGGGG	0.597000													5	22					0	0	1	0	0
C1GALT1C1	29071	broad.mit.edu	37	X	119760538	119760538	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chrX:119760538C>T	ENST00000304661.5	-	2	722	c.484G>A	c.(484-486)Gat>Aat	p.D162N	C1GALT1C1_ENST00000371313.2_Missense_Mutation_p.D162N	NM_001011551.2	NP_001011551.1	Q96EU7	C1GLC_HUMAN	C1GALT1-specific chaperone 1	162						integral to membrane				breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(1)	11						TGTGATGGATCCTTTTTTAAC	0.383000													27	46					0	0	1	0	0
PCNT	5116	broad.mit.edu	37	21	47809235	47809235	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr21:47809235C>T	ENST00000359568.5	+	19	3836	c.3729C>T	c.(3727-3729)ctC>ctT	p.L1243L	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	1243					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					AAAGCTTTCTCATGAGCCCAG	0.577000													31	83					0	0	1	0	0
FLRT2	23768	broad.mit.edu	37	14	86089433	86089433	+	Silent	SNP	A	A	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr14:86089433A>G	ENST00000330753.4	+	2	2342	c.1575A>G	c.(1573-1575)acA>acG	p.T525T	FLRT2_ENST00000554746.1_Silent_p.T525T	NM_013231.4	NP_037363.1	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	525					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(21)|lung(27)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	73				BRCA - Breast invasive adenocarcinoma(234;0.0319)		GCAGCAACACAGCGTCCAGCC	0.577000													21	143					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124402857	124402857	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:124402857C>T	ENST00000338354.3	+	53	7291	c.7185C>T	c.(7183-7185)gtC>gtT	p.V2395V	DMBT1_ENST00000344338.3_Silent_p.V2385V|DMBT1_ENST00000368955.3_Silent_p.V2385V|DMBT1_ENST00000330163.4_Silent_p.V1767V|DMBT1_ENST00000359586.6_Silent_p.V1115V|DMBT1_ENST00000368956.2_Silent_p.V1767V|DMBT1_ENST00000368909.3_Silent_p.V2395V			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	2395					epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding	p.V2395V(3)|p.V2524V(2)		breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				AGGTGGACGTCGTCCTGGGTC	0.647000													17	41					0	0	1	0	0
BFSP1	631	broad.mit.edu	37	20	17492687	17492687	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr20:17492687G>C	ENST00000377873.3	-	4	600	c.561C>G	c.(559-561)atC>atG	p.I187M	BFSP1_ENST00000544874.1_Missense_Mutation_p.I48M|BFSP1_ENST00000473415.1_5'UTR|BFSP1_ENST00000377868.2_Missense_Mutation_p.I62M|BFSP1_ENST00000536626.1_Missense_Mutation_p.I48M	NM_001195.3	NP_001186.1	Q12934	BFSP1_HUMAN	beaded filament structural protein 1, filensin	187	Linker 12.|Rod.					cytoplasm|intermediate filament|membrane	structural constituent of cytoskeleton|structural constituent of eye lens			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(7)|prostate(2)|skin(1)|stomach(1)	18						GCAGGATGCTGATATAGGTCT	0.473000													17	62					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21399954	21399954	+	Nonsense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr18:21399954C>G	ENST00000313654.9	+	19	2538	c.2297C>G	c.(2296-2298)tCa>tGa	p.S766*	LAMA3_ENST00000399516.3_Nonsense_Mutation_p.S766*	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	766					cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CAAATGACCTCAGTACAGGTA	0.527000													9	67					0	0	1	0	0
GNL3L	54552	broad.mit.edu	37	X	54578731	54578731	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chrX:54578731G>C	ENST00000336470.4	+	13	1327	c.1188G>C	c.(1186-1188)aaG>aaC	p.K396N	GNL3L_ENST00000360845.2_Missense_Mutation_p.K396N	NM_019067.5	NP_061940.1	Q9NVN8	GNL3L_HUMAN	guanine nucleotide binding protein-like 3 (nucleolar)-like	396					ribosome biogenesis	nucleolus	GTP binding			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	30						GCAGCGGGAAGATCAGCTTCT	0.502000													18	55					0	0	1	0	0
ZNF814	730051	broad.mit.edu	37	19	58385762	58385762	+	Silent	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:58385762C>G	ENST00000435989.2	-	3	1230	c.996G>C	c.(994-996)tcG>tcC	p.S332S	ZNF814_ENST00000597342.1_Intron|ZNF814_ENST00000600634.1_Intron|ZNF814_ENST00000595295.1_Intron|ZNF814_ENST00000597832.1_Intron|ZNF814_ENST00000596604.1_Intron	NM_001144989.1	NP_001138461.1	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	332					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.S332S(2)		NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						ATTTGCTAAACGATTTCCCAC	0.358000													2	12					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78272261	78272261	+	Missense_Mutation	SNP	C	C	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:78272261C>A	ENST00000582970.1	+	11	2296	c.2153C>A	c.(2152-2154)aCc>aAc	p.T718N	RNF213_ENST00000456466.1_Missense_Mutation_p.T718N|RNF213_ENST00000508628.2_Missense_Mutation_p.T767N|RNF213_ENST00000319921.4_Missense_Mutation_p.T718N	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	718										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			CCTGAGGACACCTGGGCCGCT	0.582000													14	49					9.31168e-06	9.56066e-06	1	1	0
ZNF672	79894	broad.mit.edu	37	1	249142042	249142042	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:249142042C>G	ENST00000306562.3	+	4	1315	c.569C>G	c.(568-570)cCc>cGc	p.P190R		NM_024836.1	NP_079112.1	Q499Z4	ZN672_HUMAN	zinc finger protein 672	190					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(1)	5	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			TCCCGGAGCCCCACGCGACCC	0.716000													6	17					0	0	1	0	0
RET	5979	broad.mit.edu	37	10	43620387	43620387	+	Missense_Mutation	SNP	C	C	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:43620387C>A	ENST00000355710.3	+	18	3228	c.2996C>A	c.(2995-2997)gCg>gAg	p.A999E	RET_ENST00000340058.5_Missense_Mutation_p.A999E	NM_020975.4	NP_066124.1	P07949	RET_HUMAN	ret proto-oncogene	999	Protein kinase.				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity		CCDC6/RET(4)|KIF5B/RET(79)	NS(2)|adrenal_gland(26)|breast(5)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|lung(27)|ovary(5)|prostate(3)|skin(1)|thyroid(504)|upper_aerodigestive_tract(1)|urinary_tract(1)	607		Ovarian(717;0.0423)			Sunitinib(DB01268)	CCGGTGTTTGCGGACATCAGC	0.557000		1	"""T, Mis, N, F"""	"""H4, PRKAR1A, NCOA4, PCM1, GOLGA5, TRIM33, KTN1, TRIM27, HOOK3, KIF5B, CCDC6"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma, NSCLC"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma"""	Hirschsprung disease		Multiple Endocrine Neoplasia, type 2B;Multiple Endocrine Neoplasia, type 2A;Familial Medullary Thyroid Carcinoma				21	69					4.4004e-07	4.57928e-07	1	1	0
VAPA	9218	broad.mit.edu	37	18	9914267	9914267	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr18:9914267C>T	ENST00000400000.2	+	1	269	c.14C>T	c.(13-15)tCa>tTa	p.S5L	VAPA_ENST00000340541.4_Missense_Mutation_p.S5L	NM_003574.5|NM_194434.2	NP_003565.4|NP_919415.2	Q9P0L0	VAPA_HUMAN	VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa	5					cell death|cellular membrane fusion|neuron projection development|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein localization in endoplasmic reticulum|sphingolipid metabolic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane|vesicle	protein heterodimerization activity|signal transducer activity|structural molecule activity			breast(1)|lung(2)|prostate(1)	4						GCGTCCGCCTCAGGGGCCATG	0.716000													4	17					0	0	1	0	0
MED12L	116931	broad.mit.edu	37	3	151112453	151112453	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr3:151112453G>C	ENST00000474524.1	+	37	5551	c.5513G>C	c.(5512-5514)aGa>aCa	p.R1838T	MED12L_ENST00000273432.4_Missense_Mutation_p.R1698T	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	1838					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GGTGGCTCCAGATTGGACCCT	0.463000													39	156					0	0	1	0	0
SLC12A5	57468	broad.mit.edu	37	20	44676672	44676672	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr20:44676672C>G	ENST00000243964.3	+	16	2058	c.1960C>G	c.(1960-1962)Cgc>Ggc	p.R654G	SLC12A5_ENST00000454036.2_Missense_Mutation_p.R677G	NM_020708.4	NP_065759.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	677					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	CAGTGCGGCTCGCTATGCCCT	0.602000													4	17					0	0	1	0	0
EMID1	129080	broad.mit.edu	37	22	29628275	29628275	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr22:29628275G>A	ENST00000334018.6	+	8	895	c.707G>A	c.(706-708)cGg>cAg	p.R236Q	EMID1_ENST00000484039.1_3'UTR|EMID1_ENST00000404820.3_Missense_Mutation_p.R236Q|EMID1_ENST00000404755.3_Missense_Mutation_p.R236Q	NM_001267895.1|NM_133455.3	NP_001254824.1|NP_597712.2	Q96A84	EMID1_HUMAN	EMI domain containing 1	234	Collagen-like.					collagen				NS(1)|endometrium(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(2)|skin(3)	12						AGCCCTGGCCGGGCTGGAGCT	0.701000													31	25					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10235464	10235464	+	Silent	SNP	G	G	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:10235464G>T	ENST00000418404.3	-	19	2413	c.2250C>A	c.(2248-2250)ctC>ctA	p.L750L	MYH13_ENST00000252172.4_Silent_p.L750L|RP11-401O9.3_ENST00000577743.1_RNA			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	750	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity	p.L750L(2)		breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						CGATGGAGTTGAGGAGCTTCT	0.552000													14	130					1.05317e-09	1.11104e-09	1	1	0
EGFLAM	133584	broad.mit.edu	37	5	38435313	38435313	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:38435313G>C	ENST00000322350.5	+	16	2587	c.2241G>C	c.(2239-2241)aaG>aaC	p.K747N	EGFLAM_ENST00000336740.6_Missense_Mutation_p.K513N|EGFLAM_ENST00000397202.2_Missense_Mutation_p.K113N|EGFLAM_ENST00000354891.3_Missense_Mutation_p.K747N	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	747	Laminin G-like 2.					cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					ATGTGAAGAAGAACTCGGGTG	0.463000													30	113					0	0	1	0	0
CDH22	64405	broad.mit.edu	37	20	44806753	44806753	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr20:44806753C>T	ENST00000372262.3	-	10	2147	c.1747G>A	c.(1747-1749)Gac>Aac	p.D583N	CDH22_ENST00000537909.1_Missense_Mutation_p.D583N	NM_021248.1	NP_067071.1	Q9UJ99	CAD22_HUMAN	cadherin 22, type 2	583	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	44		Myeloproliferative disorder(115;0.0122)				GGCCCACTGTCTACCACCAGG	0.632000													6	37					0	0	1	0	0
SMCHD1	23347	broad.mit.edu	37	18	2732308	2732308	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr18:2732308C>G	ENST00000320876.6	+	25	3432	c.3094C>G	c.(3094-3096)Ccc>Gcc	p.P1032A	SMCHD1_ENST00000261598.8_Missense_Mutation_p.P1032A|RP11-703M24.5_ENST00000583546.1_RNA	NM_015295.2	NP_056110.2	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible hinge domain containing 1	1032					chromosome organization		ATP binding			NS(3)|breast(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(16)|lung(15)|pancreas(1)	45						TAAGTTGCTTCCCAGTAGCCA	0.383000													35	95					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9076183	9076183	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:9076183G>C	ENST00000397910.4	-	3	11466	c.11263C>G	c.(11263-11265)Cag>Gag	p.Q3755E		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3756	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTGGCCCCCTGAGGAGCTGAG	0.522000													30	138					0	0	1	0	0
FAM115A	9747	broad.mit.edu	37	7	143573631	143573631	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:143573631G>A	ENST00000479870.1	-	2	279	c.71C>T	c.(70-72)gCt>gTt	p.A24V	FAM115A_ENST00000355951.2_Missense_Mutation_p.A24V|FAM115A_ENST00000392900.3_Intron	NM_001206938.1|NM_001206941.1|NM_014719.2	NP_001193867.1|NP_001193870.1|NP_055534	Q9Y4C2	F115A_HUMAN	family with sequence similarity 115, member A	24										NS(1)|endometrium(1)|lung(5)	7	Melanoma(164;0.0903)					ACATGGAACAGCATCTTCGGG	0.527000													4	60					0	0	1	0	0
PLEKHA5	54477	broad.mit.edu	37	12	19406895	19406895	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:19406895C>T	ENST00000538714.1	+	4	253	c.249C>T	c.(247-249)acC>acT	p.T83T	PLEKHA5_ENST00000539256.1_5'UTR|PLEKHA5_ENST00000359180.3_Silent_p.T83T|PLEKHA5_ENST00000424268.1_5'UTR|PLEKHA5_ENST00000299275.6_Silent_p.T83T|PLEKHA5_ENST00000355397.3_Silent_p.T83T|PLEKHA5_ENST00000317589.4_Silent_p.T83T|PLEKHA5_ENST00000429027.2_Silent_p.T83T|PLEKHA5_ENST00000309364.4_Silent_p.T83T|PLEKHA5_ENST00000543806.1_5'UTR	NM_001143821.2	NP_001137293.2	Q9HAU0	PKHA5_HUMAN	pleckstrin homology domain containing, family A member 5	83	WW 2.						1-phosphatidylinositol binding|protein binding			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(14)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)					GGAAAGTGACCTGCAAACATC	0.323000													109	79					0	0	1	0	0
CAPSL	133690	broad.mit.edu	37	5	35910153	35910153	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:35910153C>G	ENST00000397367.2	-	4	466	c.340G>C	c.(340-342)Gag>Cag	p.E114Q	CAPSL_ENST00000514524.1_Missense_Mutation_p.E114Q|CAPSL_ENST00000397366.1_Missense_Mutation_p.E114Q	NM_144647.3	NP_653248.3	Q8WWF8	CAPSL_HUMAN	calcyphosine-like	114	EF-hand 3.					cytoplasm	calcium ion binding			central_nervous_system(1)|kidney(1)|large_intestine(5)|lung(10)|skin(1)|urinary_tract(1)	19	all_lung(31;0.000268)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.167)|Colorectal(62;0.202)			ATGATTACCTCTTTTCTGGCT	0.353000													55	144					0	0	1	0	0
FBXO43	286151	broad.mit.edu	37	8	101154324	101154324	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:101154324G>A	ENST00000428847.2	-	2	474	c.158C>T	c.(157-159)tCt>tTt	p.S53F		NM_001029860.3	NP_001025031.2	Q4G163	FBX43_HUMAN	F-box protein 43	53					meiosis		zinc ion binding			endometrium(1)|kidney(4)|large_intestine(5)|lung(14)|prostate(1)|skin(5)|urinary_tract(1)	31	all_cancers(14;0.000139)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000274)|all_lung(17;0.000798)		Epithelial(11;1.17e-09)|all cancers(13;1.34e-07)|OV - Ovarian serous cystadenocarcinoma(57;3.82e-05)|STAD - Stomach adenocarcinoma(118;0.0957)			AATTGGAGGAGAGTCCGCCCC	0.423000													95	39					0	0	1	0	0
PRKG2	5593	broad.mit.edu	37	4	82126175	82126175	+	Silent	SNP	T	T	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr4:82126175T>C	ENST00000395578.1	-	2	143	c.27A>G	c.(25-27)aaA>aaG	p.K9K	PRKG2_ENST00000264399.1_Silent_p.K9K|PRKG2_ENST00000418486.2_Silent_p.K9K			Q13237	KGP2_HUMAN	protein kinase, cGMP-dependent, type II	9					platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			NS(1)|breast(4)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(7)|lung(14)|ovary(1)|skin(2)	37						GCTTAGAATGTTTAGGTTTCA	0.502000													10	40					0	0	1	0	0
RBM22	55696	broad.mit.edu	37	5	150080509	150080509	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:150080509C>G	ENST00000199814.4	-	1	160	c.39G>C	c.(37-39)caG>caC	p.Q13H	RBM22_ENST00000447771.2_Missense_Mutation_p.Q13H|RBM22_ENST00000540000.1_Missense_Mutation_p.Q13H	NM_018047.2	NP_060517.1	Q9NW64	RBM22_HUMAN	RNA binding motif protein 22	13					protein import into nucleus, translocation	catalytic step 2 spliceosome|cytoplasm	calcium-dependent protein binding|nucleotide binding|RNA binding|zinc ion binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(4)|ovary(1)	17		Medulloblastoma(196;0.167)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCTCCCAGTTCTGCCTGTTGT	0.637000											OREG0016939	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	33	31					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9857673	9857673	+	Missense_Mutation	SNP	C	C	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:9857673C>A	ENST00000396573.2	-	14	4037	c.3728G>T	c.(3727-3729)gGg>gTg	p.G1243V	GRIN2A_ENST00000330684.3_Missense_Mutation_p.G1243V|GRIN2A_ENST00000396575.2_Missense_Mutation_p.G1243V|GRIN2A_ENST00000404927.2_Missense_Mutation_p.G1243V|GRIN2A_ENST00000562109.1_Missense_Mutation_p.G1243V|GRIN2A_ENST00000535259.1_Missense_Mutation_p.G1086V	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	1243					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	ATAGAGGTTCCCCATCCGCAG	0.572000													68	52					1.50372e-20	1.63115e-20	1	1	0
TMLHE	55217	broad.mit.edu	37	X	154736681	154736681	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chrX:154736681G>A	ENST00000334398.3	-	6	1018	c.873C>T	c.(871-873)ctC>ctT	p.L291L	TMLHE_ENST00000369439.4_Silent_p.L291L|TMLHE-AS1_ENST00000452506.1_RNA	NM_018196.3	NP_060666.1	Q9NVH6	TMLH_HUMAN	trimethyllysine hydroxylase, epsilon	291					carnitine biosynthetic process	mitochondrial matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|trimethyllysine dioxygenase activity	p.L291L(1)		breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	20	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Succinic acid(DB00139)|Vitamin C(DB00126)	CTTTACTGAGGAGTTCAAATT	0.418000													90	48					0	0	1	0	0
RNF17	56163	broad.mit.edu	37	13	25416223	25416223	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr13:25416223C>G	ENST00000255324.5	+	19	2579	c.2527C>G	c.(2527-2529)Ctt>Gtt	p.L843V	RNF17_ENST00000381921.1_Missense_Mutation_p.L843V	NM_001184993.1|NM_031277.2	NP_001171922.1|NP_112567.2	Q9BXT8	RNF17_HUMAN	ring finger protein 17	843					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding	p.L843F(1)		NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(3)|skin(6)	36		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		TTTCGATTCTCTTGGTGCTCC	0.333000													7	70					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132502842	132502842	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:132502842C>T	ENST00000333577.4	+	22	4415	c.4306C>T	c.(4306-4308)Ccg>Tcg	p.P1436S	EP400_ENST00000332482.4_Missense_Mutation_p.P1363S|EP400_ENST00000330386.6_Missense_Mutation_p.P1400S|EP400_ENST00000389561.2_Missense_Mutation_p.P1400S|EP400_ENST00000389562.2_Missense_Mutation_p.P1399S			Q96L91	EP400_HUMAN	E1A binding protein p400	1436					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		GAAAAAGATACCGCGGAAACT	0.502000													31	47					0	0	1	0	0
SYNDIG1	79953	broad.mit.edu	37	20	24524190	24524190	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr20:24524190G>A	ENST00000376862.3	+	2	1090	c.457G>A	c.(457-459)Gag>Aag	p.E153K		NM_024893.1	NP_079169.1	Q9H7V2	SYNG1_HUMAN	synapse differentiation inducing 1	153	Poly-Glu.				response to biotic stimulus	early endosome membrane|integral to membrane|plasma membrane				breast(2)|endometrium(1)|large_intestine(3)|lung(14)|prostate(1)|skin(3)	24						TGTGGAGGAGGAGGAGGAGTT	0.542000													44	114					0	0	1	0	0
ASCC3	10973	broad.mit.edu	37	6	101214503	101214503	+	Missense_Mutation	SNP	T	T	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:101214503T>C	ENST00000369162.2	-	10	2019	c.1675A>G	c.(1675-1677)Atc>Gtc	p.I559V	ASCC3_ENST00000522650.1_Missense_Mutation_p.I559V	NM_006828.2	NP_006819.2	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit 3	559	Helicase ATP-binding 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(20)|liver(1)|lung(36)|ovary(6)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	92		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		TTCACAATGATGCCTAGTGGC	0.383000													42	74					0	0	1	0	0
TCERG1L	256536	broad.mit.edu	37	10	132891546	132891546	+	Missense_Mutation	SNP	C	C	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:132891546C>A	ENST00000368642.4	-	12	1725	c.1640G>T	c.(1639-1641)cGg>cTg	p.R547L		NM_174937.3	NP_777597.2	Q5VWI1	TCRGL_HUMAN	transcription elongation regulator 1-like	547	FF 2.									cervix(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	31		all_cancers(35;1.22e-10)|all_epithelial(44;2.65e-09)|Lung NSC(174;0.00188)|all_lung(145;0.00307)|Melanoma(40;0.0179)|all_neural(114;0.0424)|Breast(234;0.0743)|Colorectal(57;0.09)		all cancers(32;0.000899)|OV - Ovarian serous cystadenocarcinoma(35;0.0021)|Epithelial(32;0.00276)		CCTCTGATCCCGGCCGTATTT	0.443000													8	96					0.000157383	0.000160732	1	1	0
OR5D13	390142	broad.mit.edu	37	11	55541543	55541543	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:55541543G>A	ENST00000361760.1	+	1	630	c.630G>A	c.(628-630)gtG>gtA	p.V210V		NM_001001967.1	NP_001001967.1	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D, member 13	210					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(1)|lung(20)|ovary(1)|pancreas(2)|skin(2)|stomach(1)|urinary_tract(1)	40		all_epithelial(135;0.196)				TCAATGAGGTGAGCAGCCTAA	0.403000													24	124					0	0	1	0	0
GPR22	2845	broad.mit.edu	37	7	107114751	107114751	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:107114751G>T	ENST00000304402.4	+	3	1589	c.246G>T	c.(244-246)atG>atT	p.M82I	COG5_ENST00000347053.3_Intron|COG5_ENST00000297135.3_Intron|COG5_ENST00000475638.2_Intron|COG5_ENST00000393603.2_Intron	NM_005295.2	NP_005286.2	Q99680	GPR22_HUMAN	G protein-coupled receptor 22	82						integral to plasma membrane	G-protein coupled receptor activity			large_intestine(3)|lung(6)|ovary(2)|stomach(1)	12						TTATTACAATGAATCTTCATG	0.363000													58	94					5.22555e-25	5.7006e-25	1	1	0
TYK2	7297	broad.mit.edu	37	19	10488945	10488945	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:10488945G>A	ENST00000525621.1	-	3	619	c.138C>T	c.(136-138)ttC>ttT	p.F46F	TYK2_ENST00000264818.6_Silent_p.F46F|TYK2_ENST00000524462.1_Intron|TYK2_ENST00000529370.1_Silent_p.F46F	NM_003331.4	NP_003322.3	P29597	TYK2_HUMAN	tyrosine kinase 2	46	FERM.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(11)|kidney(6)|large_intestine(3)|lung(19)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			ATGACTCACTGAAAGTGACCC	0.622000													29	45					0	0	1	0	0
ZBTB7A	51341	broad.mit.edu	37	19	4054074	4054074	+	Missense_Mutation	SNP	A	A	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:4054074A>T	ENST00000322357.4	-	2	1435	c.1157T>A	c.(1156-1158)aTc>aAc	p.I386N	ZBTB7A_ENST00000601588.1_Missense_Mutation_p.I386N	NM_015898.2	NP_056982.1	O95365	ZBT7A_HUMAN	zinc finger and BTB domain containing 7A	386					cell differentiation|multicellular organismal development|transcription, DNA-dependent	nucleus	DNA binding|histone acetyltransferase binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	14		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.014)|STAD - Stomach adenocarcinoma(1328;0.18)		CTTCTCGCAGATGGGGCACTT	0.637000													29	43					0	0	1	0	0
MOAP1	64112	broad.mit.edu	37	14	93650482	93650482	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr14:93650482C>A	ENST00000556883.1	-	2	590	c.106G>T	c.(106-108)Gag>Tag	p.E36*	MOAP1_ENST00000298894.4_Nonsense_Mutation_p.E36*			Q96BY2	MOAP1_HUMAN	modulator of apoptosis 1	36					activation of caspase activity|apoptotic nuclear change	cytoplasm	protein homodimerization activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|ovary(1)|skin(2)	13		all_cancers(154;0.00528)|Acute lymphoblastic leukemia(33;0.0497)|all_epithelial(191;0.125)|all_neural(303;0.13)		Epithelial(152;0.178)|all cancers(159;0.2)|COAD - Colon adenocarcinoma(157;0.204)		agagcctcctcgatttctgcc	0.537000													122	147					7.97055e-49	8.92329e-49	1	1	0
SLC17A2	10246	broad.mit.edu	37	6	25918715	25918715	+	Splice_Site	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:25918715C>T	ENST00000377850.3	-	6	1173	c.649G>A	c.(649-651)Ggt>Agt	p.G217S	SLC17A2_ENST00000360488.3_Splice_Site_p.G217S|SLC17A2_ENST00000265425.3_Splice_Site_p.G217S			O00624	NPT3_HUMAN	solute carrier family 17, member 2	217					phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			endometrium(3)|kidney(1)|large_intestine(9)|lung(12)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	31						AGTGACTCACCAAAGATGTAG	0.443000													11	59					0	0	1	0	0
DCT	1638	broad.mit.edu	37	13	95114445	95114445	+	Splice_Site	SNP	T	T	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr13:95114445T>A	ENST00000377028.5	-	5	1277		c.e5-2		DCT_ENST00000490854.1_Splice_Site|DCT_ENST00000446125.1_Splice_Site	NM_001922.3	NP_001913.2	P40126	TYRP2_HUMAN	dopachrome tautomerase						epidermis development|melanin biosynthetic process from tyrosine	cytosol|integral to membrane|melanosome membrane|microsome	copper ion binding|dopachrome isomerase activity|oxidoreductase activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	50	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;3.71e-42)|all_epithelial(2;3.76e-31)|all_lung(2;5.16e-14)|Lung NSC(4;1.33e-13)|Breast(118;0.0013)|Hepatocellular(115;0.00886)|Renal(2;0.00988)		COAD - Colon adenocarcinoma(199;7.07e-05)|GBM - Glioblastoma multiforme(99;0.000472)		TCATCCAAGCTAAGATTTGTA	0.433000													9	47					0	0	1	0	0
IGKV1-8	28942	broad.mit.edu	37	2	89292027	89292027	+	RNA	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr2:89292027G>A	ENST00000495489.1	-	0	298																											CACTGCCGCTGAACCTTGATG	0.463000													149	120					0	0	1	0	0
DNAAF3	352909	broad.mit.edu	37	19	55676784	55676784	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:55676784C>T	ENST00000527223.2	-	4	481	c.480G>A	c.(478-480)ctG>ctA	p.L160L	DNAAF3_ENST00000391720.4_Silent_p.L139L|DNAAF3_ENST00000524407.2_Silent_p.L92L|DNAAF3_ENST00000455045.1_Silent_p.L38L|CTD-2587H24.5_ENST00000591665.1_RNA	NM_001256714.1	NP_001243643	Q8N9W5	CS051_HUMAN	dynein, axonemal, assembly factor 3	92																	GGCTGAAGATCAGCATGTGTC	0.547000													43	21					0	0	1	0	0
NSMAF	8439	broad.mit.edu	37	8	59506850	59506850	+	Splice_Site	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:59506850C>G	ENST00000038176.3	-	23	2105		c.e23-1		NSMAF_ENST00000427130.2_Splice_Site	NM_003580.3	NP_003571.2	Q92636	FAN_HUMAN	neutral sphingomyelinase (N-SMase) activation associated factor						ceramide metabolic process	cytoplasm|soluble fraction	protein binding|receptor signaling protein activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	38		all_lung(136;0.174)|Lung NSC(129;0.2)				AGTAACTGCTCTGCTCAAAAA	0.388000													4	43					0	0	1	0	0
ZNF236	7776	broad.mit.edu	37	18	74607060	74607060	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr18:74607060C>G	ENST00000253159.8	+	10	1701	c.1503C>G	c.(1501-1503)atC>atG	p.I501M	ZNF236_ENST00000320610.9_Missense_Mutation_p.I503M	NM_007345.3	NP_031371.3	Q9UL36	ZN236_HUMAN	zinc finger protein 236	501					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(43)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	94		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		TCCGCCACATCCGCATCCACA	0.647000													42	55					0	0	1	0	0
STIL	6491	broad.mit.edu	37	1	47767248	47767248	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:47767248G>A	ENST00000360380.3	-	6	801	c.438C>T	c.(436-438)ttC>ttT	p.F146F	STIL_ENST00000371877.3_Silent_p.F146F|STIL_ENST00000396221.2_Silent_p.F146F|STIL_ENST00000337817.5_Silent_p.F146F|STIL_ENST00000243182.6_Silent_p.F146F	NM_001282936.1	NP_001269865.1	Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus	146					cell proliferation|multicellular organismal development	centrosome|cytosol				central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	36		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				AAGCTGAACTGAAGTCATCTA	0.348000													46	29					0	0	1	0	0
CDH4	1002	broad.mit.edu	37	20	60511869	60511869	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr20:60511869C>T	ENST00000360469.5	+	16	2707	c.2619C>T	c.(2617-2619)agC>agT	p.S873S	CDH4_ENST00000543233.1_Silent_p.S799S	NM_001794.3	NP_001785.2	P55283	CADH4_HUMAN	cadherin 4, type 1, R-cadherin (retinal)	873	Ser-rich.				adherens junction organization|cell junction assembly		calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(2)|lung(25)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			ACGAGGGGAGCGGCTCCACCG	0.622000													7	48					0	0	1	0	0
MAGEC2	51438	broad.mit.edu	37	X	141291225	141291225	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chrX:141291225C>G	ENST00000247452.3	-	3	896	c.549G>C	c.(547-549)aaG>aaC	p.K183N		NM_016249.3	NP_057333.1	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	183	MAGE.					cytoplasm|nucleus				NS(2)|breast(3)|endometrium(3)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)	47	Acute lymphoblastic leukemia(192;6.56e-05)					CACGGGCTCTCTTGAGTATCA	0.483000										HNSCC(46;0.14)			112	73					0	0	1	0	0
OR13C8	138802	broad.mit.edu	37	9	107332253	107332253	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr9:107332253G>A	ENST00000335040.1	+	1	805	c.805G>A	c.(805-807)Gat>Aat	p.D269N		NM_001004483.1	NP_001004483.1	Q8NGS7	O13C8_HUMAN	olfactory receptor, family 13, subfamily C, member 8	269					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(12)|ovary(1)|skin(1)	25						AGCCTCTGTTGATTCAGGTAA	0.453000													39	85					0	0	1	0	0
UBE3B	89910	broad.mit.edu	37	12	109939197	109939197	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:109939197G>A	ENST00000342494.3	+	13	1735	c.1140G>A	c.(1138-1140)ttG>ttA	p.L380L	UBE3B_ENST00000434735.2_Silent_p.L380L|UBE3B_ENST00000280774.5_Silent_p.L380L	NM_130466.3	NP_569733.2	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	380					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			NS(1)|breast(3)|endometrium(6)|kidney(4)|large_intestine(7)|lung(20)|ovary(2)|urinary_tract(2)	45						CAATGCACTTGATCACCAAAC	0.557000													111	76					0	0	1	0	0
ZNF569	148266	broad.mit.edu	37	19	37916855	37916855	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:37916855G>A	ENST00000316950.6	-	5	710	c.153C>T	c.(151-153)ttC>ttT	p.F51F	ZNF569_ENST00000392150.2_Intron|ZNF569_ENST00000589833.1_Silent_p.F75F|ZNF569_ENST00000392149.2_Silent_p.F51F|ZNF569_ENST00000592490.1_Intron	NM_152484.2	NP_689697.2	Q5MCW4	ZN569_HUMAN	zinc finger protein 569	51	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|endometrium(4)|large_intestine(16)|lung(11)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	40			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CAGGTTTGGTGAACGGATAGC	0.443000													61	794					0	0	1	0	0
PRRC2A	7916	broad.mit.edu	37	6	31601375	31601375	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:31601375G>A	ENST00000376033.2	+	17	4773	c.4539G>A	c.(4537-4539)agG>agA	p.R1513R	PRRC2A_ENST00000376007.4_Silent_p.R1513R	NM_004638.3	NP_004629.3	P48634	PRC2A_HUMAN	proline-rich coiled-coil 2A	1513	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding			breast(6)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|lung(19)|ovary(3)|pancreas(2)|prostate(4)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	70						CCTCTCCTAGGCCCCCAACCC	0.612000													12	40					0	0	1	0	0
HSP90AA1	3320	broad.mit.edu	37	14	102549376	102549376	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr14:102549376C>T	ENST00000334701.7	-	10	2397	c.2116G>A	c.(2116-2118)Gaa>Aaa	p.E706K	HSP90AA1_ENST00000441629.2_Missense_Mutation_p.E405K|HSP90AA1_ENST00000216281.8_Missense_Mutation_p.E584K	NM_001017963.2	NP_001017963.2	P07900	HS90A_HUMAN	heat shock protein 90kDa alpha (cytosolic), class A member 1	584	Required for homodimerization.				axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(6)|large_intestine(3)|liver(1)|lung(10)|ovary(2)|prostate(1)	28					Rifabutin(DB00615)	CATACCTTTTCAACTTTTTTC	0.343000													35	34					0	0	1	0	0
ZBTB7A	51341	broad.mit.edu	37	19	4048230	4048230	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:4048230C>T	ENST00000322357.4	-	3	1553	c.1275G>A	c.(1273-1275)ctG>ctA	p.L425L	ZBTB7A_ENST00000601588.1_Silent_p.L425L	NM_015898.2	NP_056982.1	O95365	ZBT7A_HUMAN	zinc finger and BTB domain containing 7A	425					cell differentiation|multicellular organismal development|transcription, DNA-dependent	nucleus	DNA binding|histone acetyltransferase binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	14		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.014)|STAD - Stomach adenocarcinoma(1328;0.18)		TGTGCACCTTCAGCTTGTCCT	0.697000													11	21					0	0	1	0	0
TYW1	55253	broad.mit.edu	37	7	66463173	66463173	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:66463173C>G	ENST00000359626.5	+	2	290	c.126C>G	c.(124-126)atC>atG	p.I42M	TYW1_ENST00000491969.1_3'UTR	NM_018264.2	NP_060734.2	Q9NV66	TYW1_HUMAN	tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)	42					tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity			breast(1)|endometrium(8)|kidney(10)|large_intestine(4)|lung(13)|ovary(1)|prostate(2)|skin(3)|stomach(2)|urinary_tract(2)	46		Lung NSC(55;0.0846)|all_lung(88;0.183)				AGATTGTCATCAAGACGCAGG	0.318000													39	118					0	0	1	0	0
LGALS9	3965	broad.mit.edu	37	17	25967659	25967659	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:25967659C>T	ENST00000395473.2	+	3	1661	c.193C>T	c.(193-195)Cgg>Tgg	p.R65W	LGALS9_ENST00000448970.2_3'UTR|LGALS9_ENST00000413914.2_Intron|AC015688.3_ENST00000584605.1_3'UTR|LGALS9_ENST00000310394.5_Missense_Mutation_p.R65W|LGALS9_ENST00000302228.5_Missense_Mutation_p.R65W|LGALS9_ENST00000313648.6_Missense_Mutation_p.R65W	NM_009587.2	NP_033665.1	O00182	LEG9_HUMAN	lectin, galactoside-binding, soluble, 9	65	Galectin 1.				positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|extracellular region	galactose binding|signal transducer activity			endometrium(3)|large_intestine(2)|lung(12)|skin(1)	18	Lung NSC(42;0.0103)		BRCA - Breast invasive adenocarcinoma(3;0.0141)	UCEC - Uterine corpus endometrioid carcinoma (53;0.155)		CTTCAACCCTCGGTTTGAAGA	0.537000													48	69					0	0	1	0	0
ETS1	2113	broad.mit.edu	37	11	128354726	128354726	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:128354726G>A	ENST00000392668.4	-	7	938	c.854C>T	c.(853-855)aCc>aTc	p.T285I	ETS1_ENST00000319397.6_Missense_Mutation_p.T241I|ETS1_ENST00000345075.4_Missense_Mutation_p.T241I|ETS1_ENST00000526145.2_Missense_Mutation_p.T241I|ETS1_ENST00000531611.1_Missense_Mutation_p.T241I|ETS1_ENST00000535549.1_Intron	NM_001143820.1	NP_001137292.1	P14921	ETS1_HUMAN	v-ets avian erythroblastosis virus E26 oncogene homolog 1						cell motility|immune response|induction of apoptosis|negative regulation of cell cycle|negative regulation of cell proliferation|PML body organization|positive regulation of cellular component movement|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|response to antibiotic|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|pleura(1)|prostate(1)|upper_aerodigestive_tract(3)	35	all_hematologic(175;0.0537)	Lung NSC(97;0.000542)|all_lung(97;0.000665)|Breast(109;0.00765)|all_neural(223;0.0351)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.47e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0174)|LUSC - Lung squamous cell carcinoma(976;0.0815)|Lung(307;0.0833)		ACCACGACTGGTCCTCCCCAT	0.418000													21	63					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39838193	39838193	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:39838193G>A	ENST00000564288.1	+	52	13915	c.13138G>A	c.(13138-13140)Gaa>Aaa	p.E4380K	MACF1_ENST00000361689.2_Missense_Mutation_p.E2318K|MACF1_ENST00000289893.4_Missense_Mutation_p.E2820K|MACF1_ENST00000476350.1_3'UTR|MACF1_ENST00000317713.7_Missense_Mutation_p.E2318K|MACF1_ENST00000567887.1_Missense_Mutation_p.E4417K|MACF1_ENST00000372915.3_Missense_Mutation_p.E4385K|MACF1_ENST00000545844.1_Missense_Mutation_p.E2318K|MACF1_ENST00000539005.1_Missense_Mutation_p.E2318K			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	4385					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TCTGGTGGAAGAAATCAATTG	0.403000													22	59					0	0	1	0	0
ANKRD13D	338692	broad.mit.edu	37	11	67068616	67068616	+	Missense_Mutation	SNP	T	T	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:67068616T>C	ENST00000447274.2	+	11	2143	c.968T>C	c.(967-969)aTt>aCt	p.I323T	ANKRD13D_ENST00000514166.1_Missense_Mutation_p.I323T|ANKRD13D_ENST00000308440.6_Missense_Mutation_p.I323T|ANKRD13D_ENST00000515828.1_Missense_Mutation_p.I60T|ANKRD13D_ENST00000511455.2_Missense_Mutation_p.I410T			Q6ZTN6	AN13D_HUMAN	ankyrin repeat domain 13 family, member D	323										endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(3)|ovary(1)	9			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			CCCGTCAAAATTGGTGAGAGG	0.632000													10	35					0	0	1	0	0
KNTC1	9735	broad.mit.edu	37	12	123024233	123024233	+	Missense_Mutation	SNP	A	A	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:123024233A>G	ENST00000333479.7	+	5	554	c.377A>G	c.(376-378)cAg>cGg	p.Q126R	KNTC1_ENST00000450485.2_Missense_Mutation_p.Q126R	NM_014708.4	NP_055523.1	P50748	KNTC1_HUMAN	kinetochore associated 1	126					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(12)|kidney(8)|large_intestine(12)|lung(20)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	72	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		GCATTTGTTCAGAAAGCTAAC	0.279000													3	1					0	0	1	0	0
KIAA0556	23247	broad.mit.edu	37	16	27761548	27761548	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:27761548G>A	ENST00000261588.4	+	16	3286	c.3267G>A	c.(3265-3267)gtG>gtA	p.V1089V		NM_015202.2	NP_056017.2	O60303	K0556_HUMAN	KIAA0556	1089										breast(4)|endometrium(7)|kidney(8)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	76						TCCGAGGCGTGAAGGACATCA	0.502000													41	72					0	0	1	0	0
KCNC4	3749	broad.mit.edu	37	1	110766110	110766110	+	Silent	SNP	C	C	T	rs139324520		TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:110766110C>T	ENST00000369787.3	+	2	1230	c.1203C>T	c.(1201-1203)taC>taT	p.Y401Y	KCNC4_ENST00000438661.2_Silent_p.Y401Y|KCNC4_ENST00000412512.2_Intron|KCNC4_ENST00000413138.3_Silent_p.Y401Y	NM_004978.4	NP_004969.2	Q03721	KCNC4_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 4	401					synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(2)|lung(11)|ovary(1)|skin(2)	32		all_cancers(81;9.88e-06)|all_epithelial(167;3.23e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0238)|all cancers(265;0.0693)|Epithelial(280;0.0748)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.135)		TGATCTACTACGCTGAGCGCA	0.592000													35	120					0	0	1	0	0
ST8SIA6	338596	broad.mit.edu	37	10	17373460	17373460	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:17373460C>T	ENST00000377602.4	-	5	543	c.469G>A	c.(469-471)Gaa>Aaa	p.E157K		NM_001004470.1	NP_001004470.1	P61647	SIA8F_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6	157					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			endometrium(3)|kidney(3)|large_intestine(4)|liver(1)|lung(24)|ovary(1)|skin(1)	37						TTTTTGCTTTCCACCTCGTAA	0.393000													22	63					0	0	1	0	0
TMC8	147138	broad.mit.edu	37	17	76134203	76134203	+	Silent	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:76134203C>G	ENST00000318430.5	+	12	1841	c.1467C>G	c.(1465-1467)ctC>ctG	p.L489L	TMC8_ENST00000589691.1_Silent_p.L266L	NM_152468.4	NP_689681.2	Q8IU68	TMC8_HUMAN	transmembrane channel-like 8	489						endoplasmic reticulum membrane|integral to membrane				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	12			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)|OV - Ovarian serous cystadenocarcinoma(97;0.192)			GGATGGGCCTCTTCTACTGCC	0.612000													34	61					0	0	1	0	0
PLS1	5357	broad.mit.edu	37	3	142403175	142403175	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr3:142403175G>T	ENST00000337777.3	+	8	1039	c.826G>T	c.(826-828)Gtg>Ttg	p.V276L	PLS1_ENST00000457734.2_Missense_Mutation_p.V276L|PLS1_ENST00000497002.1_Missense_Mutation_p.V276L	NM_002670.2	NP_002661.2	Q14651	PLSI_HUMAN	plastin 1	276	Actin-binding 1.|CH 2.					cytoplasm	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|skin(1)|stomach(1)	27						GCTGCGATGGGTGAACTACCA	0.413000													56	53					5.39261e-20	5.83314e-20	1	1	0
ZFYVE26	23503	broad.mit.edu	37	14	68264823	68264823	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr14:68264823C>T	ENST00000347230.4	-	11	2294	c.2156G>A	c.(2155-2157)aGa>aAa	p.R719K	ZFYVE26_ENST00000555452.1_Missense_Mutation_p.R719K	NM_015346.3	NP_056161.2	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	719					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(8)|lung(39)|ovary(12)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	94				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		CAGTCCATCTCTGCTTCCTGA	0.557000													62	71					0	0	1	0	0
TAS2R20	259295	broad.mit.edu	37	12	11150218	11150218	+	Missense_Mutation	SNP	T	T	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:11150218T>A	ENST00000538986.1	-	1	256	c.257A>T	c.(256-258)aAt>aTt	p.N86I	TAS2R14_ENST00000381852.4_Intron|PRR4_ENST00000536668.1_Intron	NM_176889.2	NP_795370.2	P59543	T2R20_HUMAN	taste receptor, type 2, member 20	86					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	13						TGCCCAGGCATTAGAAATAAA	0.343000													62	56					0	0	1	0	0
ZNF678	339500	broad.mit.edu	37	1	227842637	227842637	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:227842637G>C	ENST00000343776.5	+	4	1031	c.686G>C	c.(685-687)aGa>aCa	p.R229T	ZNF678_ENST00000397097.3_Missense_Mutation_p.R284T|ZNF678_ENST00000608949.1_Intron	NM_178549.3	NP_848644.2	F5GXA7	F5GXA7_HUMAN	zinc finger protein 678						regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(7)|pancreas(1)|prostate(1)	24		Prostate(94;0.0885)				CAACATAAGAGAATTCATACT	0.378000													41	221					0	0	1	0	0
CXCR2P1	3580	broad.mit.edu	37	2	218925481	218925481	+	RNA	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr2:218925481G>A	ENST00000439871.1	-	0	899					NR_002712.1																						GCAGCGGCACGATGAAGCCAA	0.527000													31	20					0	0	1	0	0
CENPF	1063	broad.mit.edu	37	1	214825065	214825065	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:214825065G>C	ENST00000366955.3	+	15	8164	c.7996G>C	c.(7996-7998)Gag>Cag	p.E2666Q	CENPF_ENST00000467765.1_3'UTR	NM_016343.3	NP_057427.3	P49454	CENPF_HUMAN	centromere protein F, 350/400kDa	2762	Sufficient for centromere localization.|Sufficient for self-association.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			NS(2)|breast(2)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(37)|lung(47)|ovary(7)|prostate(3)|skin(6)|stomach(1)|urinary_tract(1)	126				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		TCAATTGAAGGAGCTCACACT	0.348000													46	20					0	0	1	0	0
NYX	60506	broad.mit.edu	37	X	41333009	41333009	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chrX:41333009C>G	ENST00000342595.2	+	2	759	c.303C>G	c.(301-303)atC>atG	p.I101M	NYX_ENST00000378220.1_Missense_Mutation_p.I101M	NM_022567.2	NP_072089.1	Q9GZU5	NYX_HUMAN	nyctalopin	101			Missing (in CSNB1A).		response to stimulus|visual perception	intracellular|proteinaceous extracellular matrix				NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(11)|upper_aerodigestive_tract(1)	17						TGTCCTTCATCACGCCCGGCG	0.716000													2	6					0	0	1	0	0
MAPK15	225689	broad.mit.edu	37	8	144803252	144803252	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:144803252G>C	ENST00000338033.4	+	10	1119	c.1000G>C	c.(1000-1002)Gag>Cag	p.E334Q		NM_139021.2	NP_620590.2	Q8TD08	MK15_HUMAN	mitogen-activated protein kinase 15	334					protein autophosphorylation	extracellular region	ATP binding|MAP kinase activity|SH3 domain binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|skin(1)|stomach(1)	12	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CTCTGTGCCTGAGTACCGCAG	0.652000													4	27					0	0	1	0	0
DDX6	1656	broad.mit.edu	37	11	118625512	118625512	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:118625512C>T	ENST00000264018.4	-	13	1666	c.1361G>A	c.(1360-1362)gGa>gAa	p.G454E	DDX6_ENST00000534980.1_Missense_Mutation_p.G454E|DDX6_ENST00000526070.2_Missense_Mutation_p.G454E	NM_004397.4	NP_004388.2	P26196	DDX6_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 6	454	Helicase C-terminal.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|RNA-induced silencing complex|stress granule	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|RNA helicase activity			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(1)|ovary(1)|prostate(1)	13	all_hematologic(175;0.0839)	Renal(330;0.0183)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)|Hepatocellular(160;0.0893)|Breast(348;0.0979)|all_hematologic(192;0.103)		OV - Ovarian serous cystadenocarcinoma(223;3.39e-06)|BRCA - Breast invasive adenocarcinoma(274;3.4e-05)|Colorectal(284;0.0377)		AATTTCTGTTCCCAGCTGCTC	0.423000			T	IGH@	B-NHL								31	55					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237794757	237794757	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:237794757G>A	ENST00000366574.2	+	42	6788	c.6471G>A	c.(6469-6471)caG>caA	p.Q2157Q	RYR2_ENST00000360064.6_Silent_p.Q2155Q|RYR2_ENST00000542537.1_Silent_p.Q2141Q	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	2157	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TGTTTTACCAGCACCCTAATC	0.448000													33	28					0	0	1	0	0
ZNF587	84914	broad.mit.edu	37	19	58371262	58371262	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:58371262C>T	ENST00000339656.5	+	3	1664	c.1482C>T	c.(1480-1482)tgC>tgT	p.C494C	ZNF814_ENST00000597342.1_Intron|ZNF814_ENST00000595295.1_Intron|ZNF814_ENST00000597832.1_Intron|ZNF814_ENST00000596604.1_Intron|ZNF587_ENST00000423137.1_Silent_p.C493C|ZNF587_ENST00000419854.1_Silent_p.C451C	NM_001204817.1|NM_032828.3	NP_001191746.1|NP_116217.1	Q96SQ5	ZN587_HUMAN	zinc finger protein 587	494					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|pancreas(1)|stomach(1)	15		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)		CGTATGAATGCAGTGAATGTG	0.413000													42	230					0	0	1	0	0
SERPINC1	462	broad.mit.edu	37	1	173881128	173881128	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:173881128C>G	ENST00000367698.3	-	3	551	c.433G>C	c.(433-435)Gag>Cag	p.E145Q	SERPINC1_ENST00000494024.1_5'UTR	NM_000488.3	NP_000479.1	P01008	ANT3_HUMAN	serpin peptidase inhibitor, clade C (antithrombin), member 1	145					blood coagulation|regulation of proteolysis	extracellular space|plasma membrane	heparin binding|protease binding|serine-type endopeptidase inhibitor activity			NS(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(15)|ovary(1)	25					Enoxaparin(DB01225)|Fondaparinux sodium(DB00569)|Heparin(DB01109)	GATGTTTTCTCAGATATGGTG	0.433000													43	115					0	0	1	0	0
SF1	7536	broad.mit.edu	37	11	64544068	64544068	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:64544068C>T	ENST00000377390.3	-	2	399	c.62G>A	c.(61-63)cGc>cAc	p.R21H	SF1_ENST00000433274.2_5'UTR|SF1_ENST00000377394.3_Missense_Mutation_p.R21H|SF1_ENST00000334944.5_Missense_Mutation_p.R21H|SF1_ENST00000227503.9_Missense_Mutation_p.R21H|SF1_ENST00000377387.1_Missense_Mutation_p.R146H|SF1_ENST00000422298.2_5'UTR	NM_004630.3	NP_004621.2	Q15637	SF01_HUMAN	splicing factor 1	21					nuclear mRNA 3'-splice site recognition|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ribosome|spliceosomal complex	protein binding|RNA binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(12)|ovary(2)|skin(2)	31						TTGGTTCCAGCGGCTCCTCTT	0.428000													41	71					0	0	1	0	0
WDR96	80217	broad.mit.edu	37	10	105927390	105927390	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:105927390C>T	ENST00000357060.3	-	22	2912	c.2797G>A	c.(2797-2799)Gag>Aag	p.E933K	WDR96_ENST00000428666.1_Missense_Mutation_p.E934K|WDR96_ENST00000278064.2_Missense_Mutation_p.E864K	NM_025145.5	NP_079421.5	Q8NDM7	WDR96_HUMAN	WD repeat domain 96	933										NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(14)|lung(21)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						TTAAGACACTCTGCTTCAATC	0.358000													17	40					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228399583	228399583	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:228399583C>T	ENST00000570156.2	+	2	173	c.99C>T	c.(97-99)atC>atT	p.I33I	OBSCN_ENST00000366707.4_5'UTR|OBSCN_ENST00000422127.1_Silent_p.I33I|C1orf145_ENST00000295012.5_Intron|OBSCN_ENST00000366709.4_5'UTR|OBSCN_ENST00000284548.11_Silent_p.I33I	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	33	Ig-like 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GCTGCCAGATCGTGGGTAATC	0.692000													7	18					0	0	1	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64607948	64607948	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr3:64607948G>A	ENST00000498707.1	-	18	2954	c.2612C>T	c.(2611-2613)cCa>cTa	p.P871L	ADAMTS9_ENST00000295903.4_Missense_Mutation_p.P843L	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	871	Spacer.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		ATCTTCAATTGGAATATTGAA	0.438000													18	47					0	0	1	0	0
C10orf68	79741	broad.mit.edu	37	10	33000562	33000562	+	Missense_Mutation	SNP	T	T	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:33000562T>A	ENST00000375030.2	+	10	1036	c.418T>A	c.(418-420)Tca>Aca	p.S140T	C10orf68_ENST00000375028.3_Missense_Mutation_p.S108T|C10orf68_ENST00000375025.4_Missense_Mutation_p.S132T			Q9H943	CJ068_HUMAN	chromosome 10 open reading frame 68	132										breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(4)	29						TGATGAAGAATCAGGTGAAAA	0.338000													11	57					0	0	1	0	0
PIGO	84720	broad.mit.edu	37	9	35094274	35094274	+	Silent	SNP	G	G	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr9:35094274G>T	ENST00000378617.3	-	3	988	c.594C>A	c.(592-594)tcC>tcA	p.S198S	PIGO_ENST00000298004.5_Silent_p.S198S|PIGO_ENST00000341666.3_Silent_p.S198S|PIGO_ENST00000361778.2_Silent_p.S198S	NM_032634.3	NP_116023.2	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class O	198					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			endometrium(3)|kidney(2)|large_intestine(8)|lung(13)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)	38			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			TGACATTGAAGGATGGGAAGA	0.502000													12	32					6.44725e-10	6.82023e-10	1	1	0
PAX4	5078	broad.mit.edu	37	7	127255581	127255581	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:127255581G>A	ENST00000338516.3	-	2	17	c.18C>T	c.(16-18)atC>atT	p.I6I	PAX4_ENST00000341640.2_5'UTR|PAX4_ENST00000378740.2_5'UTR|PAX4_ENST00000463946.1_5'UTR			O43316	PAX4_HUMAN	paired box 4	6	Paired.				cell differentiation|endocrine pancreas development|organ morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|kidney(2)|large_intestine(6)|lung(20)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35						TCATGCTGCTGATCCCTGGGC	0.642000													9	73					0	0	1	0	0
TOMM70A	9868	broad.mit.edu	37	3	100105732	100105732	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr3:100105732C>T	ENST00000284320.5	-	2	863	c.415G>A	c.(415-417)Gag>Aag	p.E139K		NM_014820.4	NP_055635.3	O94826	TOM70_HUMAN	translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)	139					protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane translocase complex	protein binding|protein transmembrane transporter activity			endometrium(11)|large_intestine(5)|lung(10)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	32						CTAATAGCCTCAGTATAGCAC	0.383000													24	103					0	0	1	0	0
ATP6V1G2-DDX39B	100532737	broad.mit.edu	37	6	31513918	31513918	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:31513918G>A	ENST00000376185.1	-	2	173	c.151C>T	c.(151-153)Cga>Tga	p.R51*	ATP6V1G2_ENST00000376151.4_Intron|ATP6V1G2_ENST00000483170.1_5'UTR|ATP6V1G2_ENST00000303892.5_Nonsense_Mutation_p.R51*|ATP6V1G2-DDX39B_ENST00000475917.1_5'UTR|ATP6V1G2_ENST00000483251.1_Nonsense_Mutation_p.R10*																							TCGTGCTCTCGCTCTCTGCGG	0.582000													52	117					0	0	1	0	0
BCL11B	64919	broad.mit.edu	37	14	99641436	99641436	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr14:99641436C>T	ENST00000345514.2	-	3	1790	c.1524G>A	c.(1522-1524)gcG>gcA	p.A508A	BCL11B_ENST00000357195.3_Silent_p.A579A|BCL11B_ENST00000443726.2_Silent_p.A385A	NM_001282238.1|NM_022898.1	NP_001269167.1|NP_075049.1	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B (zinc finger protein)	579						nucleus	zinc ion binding			NS(3)|breast(1)|central_nervous_system(9)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(9)|prostate(2)|skin(2)	34		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		cgccgccccccgcgcccggga	0.721000			T	TLX3	T-ALL								8	19					0	0	1	0	0
INO80D	54891	broad.mit.edu	37	2	206869542	206869542	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr2:206869542C>T	ENST00000403263.1	-	11	3038	c.2634G>A	c.(2632-2634)gtG>gtA	p.V878V		NM_017759.4	NP_060229.3	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	610					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|cervix(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(9)|ovary(2)|prostate(1)|urinary_tract(2)	26						CTCCAAGTGGCACCTCAAGTT	0.547000													21	35					0	0	1	0	0
MAD1L1	8379	broad.mit.edu	37	7	2188842	2188842	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:2188842C>G	ENST00000406869.1	-	11	1575	c.1018G>C	c.(1018-1020)Gag>Cag	p.E340Q	MAD1L1_ENST00000402746.1_Missense_Mutation_p.E248Q|MAD1L1_ENST00000265854.7_Missense_Mutation_p.E340Q|MAD1L1_ENST00000399654.2_Missense_Mutation_p.E340Q			Q9Y6D9	MD1L1_HUMAN	MAD1 mitotic arrest deficient-like 1 (yeast)	340					cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase|mitotic prometaphase|mitotic telophase	actin cytoskeleton|centrosome|condensed chromosome kinetochore|cytosol|mitochondrion|nucleus|spindle	protein binding			central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|prostate(5)	36		Ovarian(82;0.0272)		UCEC - Uterine corpus endometrioid carcinoma (27;0.134)|OV - Ovarian serous cystadenocarcinoma(56;3.63e-14)		TGCTGCAGCTCAACCACGAAT	0.547000													12	34					0	0	1	0	0
ATXN7L2	127002	broad.mit.edu	37	1	110031674	110031674	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:110031674C>T	ENST00000369870.3	+	7	1004	c.989C>T	c.(988-990)aCc>aTc	p.T330I		NM_153340.4	NP_699171.3	Q5T6C5	AT7L2_HUMAN	ataxin 7-like 2	330										breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)	17		all_epithelial(167;0.00197)|all_lung(203;0.00291)|Lung NSC(277;0.00453)		Colorectal(144;0.0129)|Lung(183;0.0426)|Epithelial(280;0.0675)|READ - Rectum adenocarcinoma(129;0.0693)|all cancers(265;0.071)|LUSC - Lung squamous cell carcinoma(189;0.228)		CCCAGCAGCACCTTCTCTGTT	0.617000													87	26					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24509787	24509787	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:24509787G>C	ENST00000264463.4	-	7	1651	c.1144C>G	c.(1144-1146)Cct>Gct	p.P382A		NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	382	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		CTAAAAACAGGAGGTTCATCC	0.393000										HNSCC(23;0.051)			17	124					0	0	1	0	0
MPDZ	8777	broad.mit.edu	37	9	13119644	13119644	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr9:13119644C>T	ENST00000319217.7	-	39	5483	c.5236G>A	c.(5236-5238)Gat>Aat	p.D1746N	MPDZ_ENST00000546205.1_Missense_Mutation_p.D1760N|MPDZ_ENST00000538841.1_Missense_Mutation_p.D605N|MPDZ_ENST00000541718.1_Missense_Mutation_p.D1746N|MPDZ_ENST00000381015.4_Missense_Mutation_p.D1746N|MPDZ_ENST00000536827.1_Missense_Mutation_p.D1713N|MPDZ_ENST00000541093.1_5'UTR|MPDZ_ENST00000447879.1_Missense_Mutation_p.D1713N|MPDZ_ENST00000381022.2_Missense_Mutation_p.D1746N	NM_001261406.1	NP_001248335.1	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1746	PDZ 11.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(15)|ovary(5)|prostate(7)|stomach(1)|urinary_tract(2)	61				GBM - Glioblastoma multiforme(50;2.03e-06)		ACTCCAGTATCGTTTCTACAC	0.348000													9	58					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49698687	49698687	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr3:49698687G>A	ENST00000296452.4	+	6	9523	c.9409G>A	c.(9409-9411)Gat>Aat	p.D3137N		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	3137					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		AGTCCCCGCTGATAGCCGTGC	0.622000													15	44					0	0	1	0	0
NELL2	4753	broad.mit.edu	37	12	45173749	45173749	+	Nonsense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:45173749G>C	ENST00000429094.2	-	4	896	c.392C>G	c.(391-393)tCa>tGa	p.S131*	NELL2_ENST00000437801.2_Nonsense_Mutation_p.S181*|NELL2_ENST00000452445.2_Nonsense_Mutation_p.S131*|NELL2_ENST00000333837.4_Nonsense_Mutation_p.S154*|NELL2_ENST00000549027.1_Nonsense_Mutation_p.S130*|NELL2_ENST00000395487.2_Nonsense_Mutation_p.S130*|NELL2_ENST00000551601.1_Nonsense_Mutation_p.S130*|NELL2_ENST00000547172.1_5'UTR	NM_001145108.1	NP_001138580.1	Q99435	NELL2_HUMAN	NEL-like 2 (chicken)	131	TSP N-terminal.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(16)|lung(30)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	65	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		GTGACTGCCTGAGCGGTAATG	0.468000													28	132					0	0	1	0	0
BCL9L	283149	broad.mit.edu	37	11	118779098	118779098	+	Missense_Mutation	SNP	T	T	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:118779098T>C	ENST00000334801.3	-	2	1257	c.293A>G	c.(292-294)cAg>cGg	p.Q98R	BCL9L_ENST00000526143.1_5'UTR	NM_182557.2	NP_872363.1	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	98					negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	56	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		CACCCCTGCCTGGGGGTTCTT	0.647000													28	42					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22202880	22202880	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:22202880C>T	ENST00000374695.3	-	23	2924	c.2845G>A	c.(2845-2847)Gag>Aag	p.E949K		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	949	Laminin IV type A 2.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	TGACCAGGCTCCTCAGAGGCC	0.667000													4	16					0	0	1	0	0
SYNGR2	9144	broad.mit.edu	37	17	76167089	76167089	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:76167089C>T	ENST00000225777.3	+	2	350	c.291C>T	c.(289-291)aaC>aaT	p.N97N	SYNGR2_ENST00000585591.1_Silent_p.N97N|SYNGR2_ENST00000592456.1_3'UTR|SYNGR2_ENST00000589711.1_Intron|SYNGR2_ENST00000590201.1_Silent_p.N41N|SYNGR2_ENST00000588282.1_Silent_p.N97N			O43760	SNG2_HUMAN	synaptogyrin 2	97	MARVEL.					integral to plasma membrane				endometrium(2)|large_intestine(1)|liver(1)|lung(1)|skin(1)|urinary_tract(1)	7			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)|OV - Ovarian serous cystadenocarcinoma(97;0.0994)			AGATCAGCAACGCCACTGACC	0.582000													17	65					0	0	1	0	0
NDUFS6	4726	broad.mit.edu	37	5	1801637	1801637	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:1801637G>A	ENST00000274137.5	+	1	124	c.106G>A	c.(106-108)Ggg>Agg	p.G36R	NDUFS6_ENST00000510329.1_3'UTR|NDUFS6_ENST00000469176.1_Missense_Mutation_p.G36R	NM_004553.4	NP_004544.1	O75380	NDUS6_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)	36					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	electron carrier activity|NADH dehydrogenase (ubiquinone) activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)|prostate(1)	7					NADH(DB00157)	CTCGCCGACCGGGGAGAAGGT	0.721000													11	9					0	0	1	0	0
ZNF232	7775	broad.mit.edu	37	17	5009425	5009425	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:5009425G>A	ENST00000250076.3	-	5	1683	c.1029C>T	c.(1027-1029)agC>agT	p.S343S	ZNF232_ENST00000416429.2_3'UTR|ZNF232_ENST00000575898.1_Silent_p.S334S	NM_014519.2	NP_055334.2	Q9UNY5	ZN232_HUMAN	zinc finger protein 232	316					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			kidney(1)|large_intestine(2)|liver(1)|lung(4)|ovary(1)|prostate(2)	11						CGAGGTTTGAGCTCTGTTTGA	0.433000													11	206					0	0	1	0	0
IWS1	55677	broad.mit.edu	37	2	128253576	128253576	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr2:128253576C>G	ENST00000295321.4	-	7	1973	c.1714G>C	c.(1714-1716)Gag>Cag	p.E572Q	AC010976.2_ENST00000599001.1_RNA|IWS1_ENST00000455721.2_3'UTR	NM_017969.2	NP_060439.2	Q96ST2	IWS1_HUMAN	IWS1 homolog (S. cerevisiae)	572					transcription, DNA-dependent	nucleus	DNA binding			cervix(1)|endometrium(2)|kidney(6)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	28	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0735)		CAGCTCACCTCAGCAGCTTCA	0.468000													119	85					0	0	1	0	0
CYP4F11	57834	broad.mit.edu	37	19	16038102	16038102	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:16038102G>A	ENST00000402119.4	-	4	871	c.445C>T	c.(445-447)Cgg>Tgg	p.R149W	CYP4F11_ENST00000326742.8_Missense_Mutation_p.R149W|CYP4F11_ENST00000591841.1_5'UTR|CYP4F11_ENST00000248041.8_Missense_Mutation_p.R149W	NM_021187.3	NP_067010.3	Q9HBI6	CP4FB_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 11						inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding	p.R149W(1)		NS(1)|breast(3)|endometrium(4)|large_intestine(2)|lung(11)|ovary(1)|skin(3)	25						GTCAACATCCGACGGTGGCGG	0.537000													10	131					0	0	1	0	0
ZC3H11A	9877	broad.mit.edu	37	1	203798669	203798669	+	Missense_Mutation	SNP	A	A	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:203798669A>G	ENST00000545588.1	+	5	4216	c.389A>G	c.(388-390)aAt>aGt	p.N130S	ZC3H11A_ENST00000332127.4_Missense_Mutation_p.N130S|ZC3H11A_ENST00000367212.3_Missense_Mutation_p.N130S|ZC3H11A_ENST00000367210.1_Missense_Mutation_p.N130S|ZC3H11A_ENST00000367214.1_Missense_Mutation_p.N130S	NM_001271675.1	NP_001258604.1	O75152	ZC11A_HUMAN	zinc finger CCCH-type containing 11A	130							nucleic acid binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32	all_cancers(21;0.0904)|all_epithelial(62;0.234)		BRCA - Breast invasive adenocarcinoma(75;0.109)			GTCCAGTCCAATCCTTCCCCT	0.483000													121	55					0	0	1	0	0
RACGAP1	29127	broad.mit.edu	37	12	50390835	50390835	+	Silent	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:50390835G>C	ENST00000434422.1	-	11	1333	c.1032C>G	c.(1030-1032)gtC>gtG	p.V344V	RACGAP1_ENST00000551016.1_Silent_p.V344V|RACGAP1_ENST00000312377.5_Silent_p.V344V|RACGAP1_ENST00000454520.2_Silent_p.V344V|RACGAP1_ENST00000547905.1_Silent_p.V344V|RACGAP1_ENST00000427314.2_Silent_p.V344V			Q9H0H5	RGAP1_HUMAN	Rac GTPase activating protein 1	344					blood coagulation|cytokinesis, actomyosin contractile ring assembly|cytokinesis, initiation of separation|embryo development|microtubule-based movement|neuroblast proliferation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|spermatogenesis|sulfate transport	acrosomal vesicle|cytosol|microtubule|midbody|nucleus|spindle	alpha-tubulin binding|beta-tubulin binding|gamma-tubulin binding|GTPase activator activity|metal ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(6)	14						CTCCAATCTTGACAGGTGTTC	0.443000													22	78					0	0	1	0	0
FBXO42	54455	broad.mit.edu	37	1	16579618	16579618	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:16579618G>A	ENST00000375592.3	-	8	1110	c.894C>T	c.(892-894)atC>atT	p.I298I		NM_018994.1	NP_061867.1	Q6P3S6	FBX42_HUMAN	F-box protein 42	298										autonomic_ganglia(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	26		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00475)|all_lung(284;0.00671)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0193)|Colorectal(212;3.16e-07)|COAD - Colon adenocarcinoma(227;1.46e-05)|BRCA - Breast invasive adenocarcinoma(304;4.37e-05)|Kidney(64;0.000246)|KIRC - Kidney renal clear cell carcinoma(64;0.00336)|STAD - Stomach adenocarcinoma(313;0.0139)|READ - Rectum adenocarcinoma(331;0.0693)		ACCCTCCGAGGATTAAGATAG	0.438000													41	16					0	0	1	0	0
BAIAP2L1	55971	broad.mit.edu	37	7	97944889	97944889	+	Silent	SNP	G	G	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:97944889G>T	ENST00000005260.8	-	7	737	c.522C>A	c.(520-522)atC>atA	p.I174I	BAIAP2L1_ENST00000462558.1_5'UTR	NM_018842.4	NP_061330.2	Q9UHR4	BI2L1_HUMAN	BAI1-associated protein 2-like 1	174	IMD.				filopodium assembly|positive regulation of actin cytoskeleton reorganization|positive regulation of actin filament polymerization|response to bacterium|signal transduction	cell junction|cytoskeleton|cytosol|nucleus	actin binding|cytoskeletal adaptor activity|proline-rich region binding|SH3 domain binding			NS(1)|breast(1)|cervix(1)|endometrium(3)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)	23	all_cancers(62;4.34e-10)|all_epithelial(64;5e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0113)|all_lung(186;0.0126)		STAD - Stomach adenocarcinoma(171;0.215)			TGAATTTCTGGATTTCACTCT	0.383000													35	119					2.20262e-25	2.4097e-25	1	1	0
RBCK1	10616	broad.mit.edu	37	20	390664	390664	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr20:390664C>T	ENST00000356286.5	+	2	867	c.162C>T	c.(160-162)gaC>gaT	p.D54D	RBCK1_ENST00000400245.3_3'UTR|RBCK1_ENST00000475269.1_Silent_p.D54D|RBCK1_ENST00000400247.3_Intron|RBCK1_ENST00000353660.3_Intron|RBCK1_ENST00000382181.2_Intron	NM_031229.2	NP_112506.2	Q9BYM8	HOIL1_HUMAN	RanBP-type and C3HC4-type zinc finger containing 1	54	Interaction with IRF3.|Interaction with TAB2.				interspecies interaction between organisms|negative regulation of NF-kappaB transcription factor activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|proteasomal ubiquitin-dependent protein catabolic process|protein linear polyubiquitination|T cell receptor signaling pathway	LUBAC complex	protein binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(1)|lung(4)	5		all_epithelial(17;0.172)|Lung NSC(37;0.191)|Breast(17;0.231)				CAACGCAGGACATCAGGTGAG	0.567000													24	41					0	0	1	0	0
HTR3A	3359	broad.mit.edu	37	11	113856847	113856847	+	Missense_Mutation	SNP	C	C	T	rs139246177		TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:113856847C>T	ENST00000504030.2	+	6	1100	c.655C>T	c.(655-657)Cgg>Tgg	p.R219W	HTR3A_ENST00000299961.5_Missense_Mutation_p.R204W|HTR3A_ENST00000355556.2_Missense_Mutation_p.R225W|HTR3A_ENST00000535865.1_Intron|HTR3A_ENST00000506841.2_Missense_Mutation_p.R219W|HTR3A_ENST00000375498.2_Missense_Mutation_p.R225W			P46098	5HT3A_HUMAN	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	219					digestion|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	serotonin binding|serotonin receptor activity|serotonin-activated cation-selective channel activity	p.R219W(1)		central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(14)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	36		all_cancers(61;2.31e-17)|all_epithelial(67;2.1e-10)|all_hematologic(158;4.64e-05)|Melanoma(852;0.000312)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0294)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.71e-06)|Epithelial(105;2.58e-05)|all cancers(92;0.000238)|OV - Ovarian serous cystadenocarcinoma(223;0.191)	Alosetron(DB00969)|Chloroprocaine(DB01161)|Cisapride(DB00604)|Dolasetron(DB00757)|Granisetron(DB00889)|Mirtazapine(DB00370)|Ondansetron(DB00904)|Palonosetron(DB00377)|Procaine(DB00721)|Tubocurarine(DB01199)	GCCCTACTTTCGGGAGTTCAG	0.478000													53	131					0	0	1	0	0
SUPT6H	6830	broad.mit.edu	37	17	27000441	27000441	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:27000441G>A	ENST00000314616.6	+	2	305	c.22G>A	c.(22-24)Gag>Aag	p.E8K	SUPT6H_ENST00000347486.4_Missense_Mutation_p.E8K	NM_003170.3	NP_003161.2	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog (S. cerevisiae)	8	Asp/Glu-rich.				chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	Lung NSC(42;0.00431)					TGTGGAAAGCGAGGCTGAGGA	0.468000													9	36					0	0	1	0	0
WNK4	65266	broad.mit.edu	37	17	40939370	40939370	+	Silent	SNP	C	C	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:40939370C>A	ENST00000246914.5	+	7	1572	c.1551C>A	c.(1549-1551)atC>atA	p.I517I	WNK4_ENST00000587705.1_3'UTR	NM_032387.4	NP_115763.2	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	517					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(10)|ovary(3)|prostate(1)|skin(5)|stomach(1)	35		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		TTGCTGCCATCCAGCGAAAGC	0.617000													32	34					6.04164e-23	6.57221e-23	1	1	0
SLC35B3	51000	broad.mit.edu	37	6	8417151	8417151	+	Missense_Mutation	SNP	C	C	G	rs145512512		TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:8417151C>G	ENST00000379660.4	-	9	1400	c.951G>C	c.(949-951)ttG>ttC	p.L317F		NM_001142540.1|NM_001142541.1|NM_015948.3	NP_001136012.1|NP_001136013.1|NP_057032.2	Q9H1N7	S35B3_HUMAN	solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3	317					transmembrane transport	Golgi membrane|integral to membrane				breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(1)|prostate(1)	15	Ovarian(93;0.0569)					AAATTTTAATCAAAGCCAGAA	0.348000													45	65					0	0	1	0	0
TULP1	7287	broad.mit.edu	37	6	35471368	35471368	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:35471368C>T	ENST00000229771.6	-	13	1370	c.1291G>A	c.(1291-1293)Gag>Aag	p.E431K	TULP1_ENST00000322263.4_Missense_Mutation_p.E378K	NM_003322.3	NP_003313.3	O00294	TULP1_HUMAN	tubby like protein 1	431					dendrite development|eye photoreceptor cell development|phagocytosis|photoreceptor cell maintenance|positive regulation of phagocytosis	cell junction|cytoplasm|extracellular region|photoreceptor inner segment|photoreceptor outer segment|synapse	actin filament binding|phosphatidylinositol-4,5-bisphosphate binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(5)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	19						CTCTCGTTCTCCGCACTCATG	0.637000													2	5					0	0	1	0	0
MYO3B	140469	broad.mit.edu	37	2	171356164	171356164	+	Silent	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr2:171356164C>G	ENST00000334231.6	+	27	3162	c.3162C>G	c.(3160-3162)ctC>ctG	p.L1054L	MYO3B_ENST00000408978.4_Silent_p.L1045L|MYO3B_ENST00000409044.3_Silent_p.L1045L|MYO3B_ENST00000602629.1_Intron			Q8WXR4	MYO3B_HUMAN	myosin IIIB	1045	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(25)|ovary(6)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	59						AGGTTTTTCTCAAATATTACC	0.388000													9	60					0	0	1	0	0
PIK3CD	5293	broad.mit.edu	37	1	9775949	9775949	+	Missense_Mutation	SNP	A	A	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:9775949A>G	ENST00000536656.1	+	5	621	c.413A>G	c.(412-414)gAc>gGc	p.D138G	PIK3CD_ENST00000377346.4_Missense_Mutation_p.D138G|PIK3CD_ENST00000361110.2_Missense_Mutation_p.D138G			O00329	PK3CD_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	138					phosphatidylinositol-mediated signaling|protein phosphorylation	phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(12)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	31	all_lung(157;0.222)	all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0231)|Colorectal(212;7.52e-08)|COAD - Colon adenocarcinoma(227;1.78e-05)|Kidney(185;0.000322)|KIRC - Kidney renal clear cell carcinoma(229;0.00114)|BRCA - Breast invasive adenocarcinoma(304;0.0021)|STAD - Stomach adenocarcinoma(132;0.00395)|READ - Rectum adenocarcinoma(331;0.0419)		GAAGTGAACGACTTTCGCGCC	0.687000													9	38					0	0	1	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140348753	140348753	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:140348753C>T	ENST00000289269.5	+	1	2934	c.2402C>T	c.(2401-2403)tCa>tTa	p.S801L	PCDHA10_ENST00000506939.2_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHAC1_ENST00000253807.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA7_ENST00000525929.1_Intron	NM_018899.5|NM_031883.2	NP_061722.1|NP_114089.1	Q9Y5I4	PCDC2_HUMAN		801					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACAGCAGGCTCAGGGAGTGAC	0.552000													28	54					0	0	1	0	0
C8orf34	116328	broad.mit.edu	37	8	69358639	69358639	+	Nonsense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:69358639C>G	ENST00000337103.4	+	2	1810	c.218C>G	c.(217-219)tCa>tGa	p.S73*	C8orf34_ENST00000348340.2_Nonsense_Mutation_p.S98*|C8orf34_ENST00000539993.1_Nonsense_Mutation_p.S98*|C8orf34_ENST00000523686.1_Nonsense_Mutation_p.S98*|C8orf34_ENST00000349492.3_3'UTR|C8orf34_ENST00000518698.1_Nonsense_Mutation_p.S184*			Q49A92	CH034_HUMAN	chromosome 8 open reading frame 34	98					signal transduction		cAMP-dependent protein kinase regulator activity			NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(9)|lung(12)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	36			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			CCTAAAAAATCAAAAAGTGAC	0.328000													6	77					0	0	1	0	0
CREB3	10488	broad.mit.edu	37	9	35735135	35735135	+	Silent	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr9:35735135G>C	ENST00000353704.2	+	5	903	c.465G>C	c.(463-465)cgG>cgC	p.R155R	CREB3_ENST00000486056.1_3'UTR	NM_006368.4	NP_006359.3	O43889	CREB3_HUMAN	cAMP responsive element binding protein 3	179					chemotaxis|induction of positive chemotaxis|interspecies interaction between organisms|negative regulation of cell cycle|positive regulation of calcium ion transport|positive regulation of cell migration|positive regulation of transcription, DNA-dependent|reactivation of latent virus|regulation of cell proliferation	cytosol|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|nucleus	cAMP response element binding protein binding|CCR1 chemokine receptor binding|DNA binding|protein dimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(2)|urinary_tract(1)	9	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)	GBM - Glioblastoma multiforme(74;0.0285)		AACGTGTGCGGAGGAAGATTC	0.443000													30	28					0	0	1	0	0
ADRBK1	156	broad.mit.edu	37	11	67051208	67051208	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:67051208C>T	ENST00000308595.5	+	16	1649	c.1359C>T	c.(1357-1359)ttC>ttT	p.F453F	ADRBK1_ENST00000527176.1_3'UTR|ADRBK1_ENST00000526285.1_Intron	NM_001619.3	NP_001610.2	P25098	ARBK1_HUMAN	adrenergic, beta, receptor kinase 1	453	Protein kinase.				activation of phospholipase C activity|cardiac muscle contraction|desensitization of G-protein coupled receptor protein signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of striated muscle contraction|negative regulation of the force of heart contraction by chemical signal|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of catecholamine secretion|tachykinin receptor signaling pathway	cytosol|soluble fraction	alpha-2A adrenergic receptor binding|ATP binding|beta-adrenergic receptor kinase activity|Edg-2 lysophosphatidic acid receptor binding|G-protein coupled receptor kinase activity|signal transducer activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|liver(2)|lung(8)|prostate(2)	22			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)		Adenosine triphosphate(DB00171)	GCCCCTTTTTCCGCTCCCTGG	0.617000													20	80					0	0	1	0	0
TMEM63A	9725	broad.mit.edu	37	1	226055673	226055673	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:226055673C>T	ENST00000366835.3	-	7	699	c.429G>A	c.(427-429)caG>caA	p.Q143Q		NM_014698.2	NP_055513.2	O94886	TM63A_HUMAN	transmembrane protein 63A	143						integral to membrane|lysosomal membrane	nucleotide binding			breast(2)|endometrium(3)|large_intestine(5)|lung(6)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	24	Breast(184;0.197)					TGATGTGCCTCTGGAAGGACA	0.542000													52	46					0	0	1	0	0
ST7	7982	broad.mit.edu	37	7	116869839	116869839	+	Silent	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:116869839C>G	ENST00000393443.1	+	16	2042	c.1428C>G	c.(1426-1428)ccC>ccG	p.P476P	ST7_ENST00000393444.3_Silent_p.P488P|ST7_ENST00000393451.3_Silent_p.P531P|ST7_ENST00000432298.1_Silent_p.P508P|ST7_ENST00000393449.1_Silent_p.P549P|ST7_ENST00000323984.3_Silent_p.P554P|ST7_ENST00000393446.2_Silent_p.P500P|ST7_ENST00000422922.1_Silent_p.P485P|ST7_ENST00000393447.4_Silent_p.P511P			Q9NRC1	ST7_HUMAN	suppression of tumorigenicity 7	0						integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|liver(2)|lung(5)|ovary(1)|skin(1)	21	all_cancers(3;3.88e-07)|all_epithelial(6;3.42e-07)|Lung NSC(10;0.00072)|all_lung(10;0.000847)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		TGTTTGCCCCCTTAAACTTTG	0.498000													89	448					0	0	1	0	0
AFF3	3899	broad.mit.edu	37	2	100209756	100209756	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr2:100209756C>G	ENST00000409236.2	-	13	2479	c.2367G>C	c.(2365-2367)ttG>ttC	p.L789F	AFF3_ENST00000356421.2_Missense_Mutation_p.L814F|AFF3_ENST00000317233.4_Missense_Mutation_p.L789F|AFF3_ENST00000409579.1_Missense_Mutation_p.L814F			P51826	AFF3_HUMAN	AF4/FMR2 family, member 3						multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						CAGGGGCGCTCAATACCCCTG	0.577000													22	40					0	0	1	0	0
MON2	23041	broad.mit.edu	37	12	62887746	62887746	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:62887746G>T	ENST00000393630.3	+	3	618	c.227G>T	c.(226-228)gGa>gTa	p.G76V	MON2_ENST00000552738.1_Missense_Mutation_p.G76V|MON2_ENST00000552115.1_Missense_Mutation_p.G76V|MON2_ENST00000393632.2_Missense_Mutation_p.G76V|MON2_ENST00000393629.2_Missense_Mutation_p.G76V|MON2_ENST00000546600.1_Missense_Mutation_p.G76V|MON2_ENST00000280379.6_Missense_Mutation_p.G76V|MON2_ENST00000549378.1_Intron	NM_001278470.1|NM_001278472.1	NP_001265399.1|NP_001265401.1	Q7Z3U7	MON2_HUMAN	MON2 homolog (S. cerevisiae)	76					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(15)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	57			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		ATGGGTTGTGGAACCAAGGAA	0.348000													4	36					1	1	1	1	0
SUSD2	56241	broad.mit.edu	37	22	24579560	24579560	+	Missense_Mutation	SNP	A	A	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr22:24579560A>T	ENST00000358321.3	+	3	646	c.385A>T	c.(385-387)Act>Tct	p.T129S		NM_019601.3	NP_062547.1	Q9UGT4	SUSD2_HUMAN	sushi domain containing 2	129					immune response	integral to membrane	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	26						CATCCCCTTCACTGTGTCACT	0.642000													45	30					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114251565	114251565	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr4:114251565G>A	ENST00000357077.4	+	27	3117	c.3064G>A	c.(3064-3066)Gaa>Aaa	p.E1022K	ANK2_ENST00000264366.6_Missense_Mutation_p.E1022K|ANK2_ENST00000509550.1_Missense_Mutation_p.E231K|ANK2_ENST00000506722.1_Missense_Mutation_p.E1013K|ANK2_ENST00000394537.3_Missense_Mutation_p.E1022K	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	1021	Interaction with SPTBN1.|ZU5.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TCCAATGGTGGAAGGAGAAGG	0.537000													39	17					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41465774	41465774	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr21:41465774C>T	ENST00000400454.1	-	21	4201	c.3724G>A	c.(3724-3726)Gac>Aac	p.D1242N		NM_001271534.1|NM_001389.3	NP_001258463.1|NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1242	Fibronectin type-III 4.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding	p.D1242N(1)		NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GAAAACGAGTCGGGAGAGGCC	0.478000													21	41					0	0	1	0	0
GABRG1	2565	broad.mit.edu	37	4	46099350	46099350	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr4:46099350C>T	ENST00000295452.4	-	2	288	c.121G>A	c.(121-123)Gat>Aat	p.D41N		NM_173536.3	NP_775807.2	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 1	41					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			breast(2)|central_nervous_system(5)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(2)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	76				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		TCATCTTCATCATCTGCCTTA	0.328000													60	58					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77356322	77356322	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:77356322C>G	ENST00000282849.5	-	14	2492	c.2074G>C	c.(2074-2076)Gaa>Caa	p.E692Q		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	692	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						AAAAAAAATTCAAAGTTCTCA	0.393000													17	102					0	0	1	0	0
IL23R	149233	broad.mit.edu	37	1	67666498	67666498	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:67666498G>A	ENST00000347310.5	+	5	741	c.570G>A	c.(568-570)aaG>aaA	p.K190K	C1orf141_ENST00000371007.2_Intron|IL23R_ENST00000371002.1_Silent_p.K190K	NM_144701.2	NP_653302.2	Q5VWK5	IL23R_HUMAN	interleukin 23 receptor	190	Fibronectin type-III 1.				inflammatory response|negative regulation of interleukin-10 production|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of interleukin-12 production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|response to interferon-gamma|response to lipopolysaccharide	interleukin-23 receptor complex	receptor activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	21						AAGGTGGCAAGAAGTACTTGG	0.373000													80	44					0	0	1	0	0
SUCLG1	8802	broad.mit.edu	37	2	84670479	84670479	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr2:84670479C>T	ENST00000393868.2	-	3	457	c.247G>A	c.(247-249)Gtt>Att	p.V83I		NM_003849.3	NP_003840.2	P53597	SUCA_HUMAN	succinate-CoA ligase, alpha subunit	83					tricarboxylic acid cycle		ATP citrate synthase activity|GTP binding|succinate-CoA ligase (GDP-forming) activity			kidney(4)|large_intestine(4)|lung(2)	10					Succinic acid(DB00139)	GTTCCTCCAACGAGTTTGGTG	0.498000													47	29					0	0	1	0	0
PIGO	84720	broad.mit.edu	37	9	35094283	35094283	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr9:35094283G>T	ENST00000378617.3	-	3	979	c.585C>A	c.(583-585)ttC>ttA	p.F195L	PIGO_ENST00000298004.5_Missense_Mutation_p.F195L|PIGO_ENST00000341666.3_Missense_Mutation_p.F195L|PIGO_ENST00000361778.2_Missense_Mutation_p.F195L	NM_032634.3	NP_116023.2	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class O	195					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			endometrium(3)|kidney(2)|large_intestine(8)|lung(13)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)	38			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			AGGATGGGAAGAAGAAAGCTT	0.498000													10	30					4.35082e-09	4.56479e-09	1	1	0
EFCAB5	374786	broad.mit.edu	37	17	28405274	28405274	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:28405274G>A	ENST00000394835.3	+	15	2971	c.2779G>A	c.(2779-2781)Gaa>Aaa	p.E927K	EFCAB5_ENST00000394832.2_Intron|EFCAB5_ENST00000320856.5_Missense_Mutation_p.E803K	NM_198529.3	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5	927							calcium ion binding			breast(7)|endometrium(2)|kidney(4)|large_intestine(11)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	43						CCCTGGTCACGAAGTGAGATT	0.413000													25	71					0	0	1	0	0
SEMA6D	80031	broad.mit.edu	37	15	48057100	48057100	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr15:48057100C>T	ENST00000316364.5	+	13	1713	c.1274C>T	c.(1273-1275)tCa>tTa	p.S425L	SEMA6D_ENST00000355997.3_Missense_Mutation_p.S425L|SEMA6D_ENST00000537942.1_Missense_Mutation_p.S425L|SEMA6D_ENST00000358066.4_Missense_Mutation_p.S425L|SEMA6D_ENST00000536845.2_Missense_Mutation_p.S425L|SEMA6D_ENST00000389433.2_Missense_Mutation_p.S425L|SEMA6D_ENST00000354744.4_Missense_Mutation_p.S425L|SEMA6D_ENST00000389428.3_Missense_Mutation_p.S425L|SEMA6D_ENST00000558014.1_Missense_Mutation_p.S425L|SEMA6D_ENST00000389425.3_Missense_Mutation_p.S425L|SEMA6D_ENST00000389432.2_Missense_Mutation_p.S425L|SEMA6D_ENST00000558816.1_Missense_Mutation_p.S425L	NM_153618.1	NP_705871.1	Q8NFY4	SEM6D_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	425	Sema.				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			biliary_tract(1)|breast(4)|endometrium(4)|kidney(5)|large_intestine(10)|lung(42)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	77		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		ACGGCCATCTCAGTGGACCAT	0.512000													22	60					0	0	1	0	0
TAF2	6873	broad.mit.edu	37	8	120770342	120770342	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:120770342C>T	ENST00000378164.2	-	21	3037	c.2739G>A	c.(2737-2739)atG>atA	p.M913I	TAF2_ENST00000519355.1_5'UTR	NM_003184.3	NP_003175	Q6P1X5	TAF2_HUMAN	TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa	913					G2/M transition of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor TFIID complex|transcription factor TFTC complex	metallopeptidase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			NS(2)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(21)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	49	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			CATTCTGAATCATATTAAGTA	0.284000													17	155					0	0	1	0	0
FBF1	85302	broad.mit.edu	37	17	73924184	73924184	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:73924184C>T	ENST00000586717.1	-	7	601	c.328G>A	c.(328-330)Gag>Aag	p.E110K	FBF1_ENST00000319129.5_Missense_Mutation_p.E110K|FBF1_ENST00000389570.4_Missense_Mutation_p.E110K			A6NLR5	A6NLR5_HUMAN	Fas (TNFRSF6) binding factor 1	110										large_intestine(2)|ovary(1)|upper_aerodigestive_tract(1)	4						TTGGGCAGCTCTCCTTTCCCA	0.537000													5	38					0	0	1	0	0
SPACA3	124912	broad.mit.edu	37	17	31324482	31324482	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:31324482C>T	ENST00000580599.1	+	5	724	c.315C>T	c.(313-315)ctC>ctT	p.L105L	SPACA3_ENST00000394637.2_3'UTR|SPACA3_ENST00000269053.3_Silent_p.L174L|SPACA3_ENST00000394638.1_Silent_p.L71L			Q8IXA5	SACA3_HUMAN	sperm acrosome associated 3	174					cell wall macromolecule catabolic process|defense response to Gram-positive bacterium|monocyte activation|peptidoglycan catabolic process|positive regulation of macrophage activation|positive regulation of phagocytosis|response to virus	acrosomal membrane|extracellular region|integral to membrane|lysosome	bacterial cell surface binding|lysozyme activity|protein binding			breast(1)|endometrium(1)|large_intestine(3)|lung(10)|ovary(2)|urinary_tract(1)	18			BRCA - Breast invasive adenocarcinoma(9;0.193)			ATCCTAATCTCAAGGATACCG	0.493000													56	102					0	0	1	0	0
SIRT1	23411	broad.mit.edu	37	10	69672769	69672769	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:69672769G>C	ENST00000212015.6	+	8	1949	c.1896G>C	c.(1894-1896)caG>caC	p.Q632H	SIRT1_ENST00000403579.1_Missense_Mutation_p.Q329H|SIRT1_ENST00000406900.1_Missense_Mutation_p.Q329H|SIRT1_ENST00000432464.1_Missense_Mutation_p.Q337H	NM_012238.4	NP_036370.2	Q96EB6	SIRT1_HUMAN	sirtuin 1	632					apoptosis|cell aging|cellular response to hydrogen peroxide|cellular response to starvation|chromatin silencing at rDNA|DNA repair|DNA replication|establishment of chromatin silencing|histone H3 deacetylation|interspecies interaction between organisms|maintenance of chromatin silencing|muscle organ development|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of fat cell differentiation|negative regulation of helicase activity|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|peptidyl-lysine acetylation|peptidyl-lysine deacetylation|positive regulation of anti-apoptosis|positive regulation of chromatin silencing|positive regulation of DNA repair|regulation of apoptosis|regulation of cell proliferation|regulation of endodeoxyribonuclease activity|regulation of protein import into nucleus, translocation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|rRNA processing|transcription, DNA-dependent|triglyceride mobilization|white fat cell differentiation	chromatin silencing complex|cytoplasm|nuclear euchromatin|nuclear heterochromatin|nuclear inner membrane|nucleolus|PML body|rDNA heterochromatin	bHLH transcription factor binding|histone binding|HLH domain binding|identical protein binding|mitogen-activated protein kinase binding|NAD+ binding|NAD-dependent histone deacetylase activity (H3-K9 specific)|p53 binding|protein C-terminus binding|transcription corepressor activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(3)|skin(1)	14						CAAAGGAGCAGATTAGTAGGC	0.393000													18	54					0	0	1	0	0
IKZF4	64375	broad.mit.edu	37	12	56427078	56427078	+	Nonsense_Mutation	SNP	A	A	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:56427078A>T	ENST00000262032.5	+	11	1337	c.970A>T	c.(970-972)Aag>Tag	p.K324*	IKZF4_ENST00000547167.1_Nonsense_Mutation_p.K324*|RP11-603J24.4_ENST00000551846.1_RNA|IKZF4_ENST00000431367.2_Nonsense_Mutation_p.K222*|IKZF4_ENST00000547791.1_Nonsense_Mutation_p.K279*			Q9H2S9	IKZF4_HUMAN	IKAROS family zinc finger 4 (Eos)	324					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|lung(3)|ovary(1)|prostate(1)	8			UCEC - Uterine corpus endometrioid carcinoma (6;0.025)|OV - Ovarian serous cystadenocarcinoma(18;0.123)			CACCAAACGCAAGCGTTCCAC	0.502000													26	247					0	0	1	0	0
BAZ1A	11177	broad.mit.edu	37	14	35227931	35227931	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr14:35227931C>G	ENST00000360310.1	-	25	4932	c.4365G>C	c.(4363-4365)ttG>ttC	p.L1455F	BAZ1A_ENST00000358716.4_Missense_Mutation_p.L1423F|BAZ1A_ENST00000382422.2_Missense_Mutation_p.L1455F	NM_013448.2	NP_038476.2	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	1455	Bromo.				chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(2)|large_intestine(7)|lung(19)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		AAACAAGTTTCAAAAAAGGCC	0.373000													24	62					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57767194	57767194	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr20:57767194G>A	ENST00000371030.2	+	1	1120	c.1120G>A	c.(1120-1122)Gag>Aag	p.E374K		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	374						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					CGCCGAGTCCGAGGGGGAggg	0.761000													6	12					0	0	1	0	0
LEPREL2	10536	broad.mit.edu	37	12	6948245	6948245	+	RNA	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:6948245C>T	ENST00000251761.8	+	0	2020				LEPREL2_ENST00000606935.1_RNA|LEPREL2_ENST00000396725.2_RNA	NM_014262.3	NP_055077.2			leprecan-like 2											breast(1)|cervix(1)|endometrium(2)|lung(6)	10						GGCCGTGACTCGGGGACGGCG	0.677000													6	25					0	0	1	0	0
MAST1	22983	broad.mit.edu	37	19	12975882	12975882	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:12975882C>T	ENST00000251472.4	+	14	1567	c.1528C>T	c.(1528-1530)Cac>Tac	p.H510Y		NM_014975.2	NP_055790.1	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase 1	510	Protein kinase.				cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(20)|ovary(5)|prostate(5)|skin(3)	56						CTCCATGGGTCACATCAAGCT	0.577000													9	82					0	0	1	0	0
LHFP	10186	broad.mit.edu	37	13	39918097	39918097	+	Missense_Mutation	SNP	C	C	G	rs142420975		TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr13:39918097C>G	ENST00000379589.3	-	4	1041	c.579G>C	c.(577-579)aaG>aaC	p.K193N		NM_005780.2	NP_005771.1	Q9Y693	LHFP_HUMAN	lipoma HMGIC fusion partner	193						integral to membrane	DNA binding		HMGA2/LHFP(2)	breast(1)|endometrium(2)|large_intestine(1)|liver(1)|lung(6)|prostate(2)	13		Lung NSC(96;3.55e-06)|Breast(139;0.00408)|Ovarian(182;0.0107)|Prostate(109;0.0118)|Lung SC(185;0.0719)|Hepatocellular(188;0.114)		OV - Ovarian serous cystadenocarcinoma(117;6.48e-46)|Epithelial(112;8.43e-42)|all cancers(112;1.42e-36)|GBM - Glioblastoma multiforme(144;0.00187)|BRCA - Breast invasive adenocarcinoma(63;0.00886)|KIRC - Kidney renal clear cell carcinoma(186;0.048)|Kidney(163;0.0601)|LUSC - Lung squamous cell carcinoma(192;0.105)		GCTTCTGTTTCTTGCCCGAAA	0.557000			T	HMGA2	lipoma								45	43					0	0	1	0	0
BCL9	607	broad.mit.edu	37	1	147095710	147095710	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:147095710C>T	ENST00000234739.3	+	10	3971	c.3231C>T	c.(3229-3231)ctC>ctT	p.L1077L		NM_004326.2	NP_004317.2	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	1077	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			breast(1)|large_intestine(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	7	all_hematologic(923;0.115)					TGCCAACCCTCAGCCCAATGG	0.493000			T	"""IGH@, IGL@"""	B-ALL								104	219					0	0	1	0	0
ATXN2L	11273	broad.mit.edu	37	16	28840778	28840778	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:28840778G>A	ENST00000336783.4	+	7	965	c.798G>A	c.(796-798)gtG>gtA	p.V266V	ATXN2L_ENST00000340394.8_Silent_p.V266V|ATXN2L_ENST00000382686.4_Silent_p.V266V|ATXN2L_ENST00000395547.2_Silent_p.V266V|ATXN2L_ENST00000564304.1_Silent_p.V266V|ATXN2L_ENST00000570200.1_Silent_p.V266V|ATXN2L_ENST00000325215.6_Silent_p.V266V	NM_007245.3	NP_009176.2	Q8WWM7	ATX2L_HUMAN	ataxin 2-like	266						membrane				breast(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36						ACTACGGTGTGAAGACTACCT	0.458000													6	58					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9015637	9015637	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:9015637C>G	ENST00000397910.4	-	29	38389	c.38186G>C	c.(38185-38187)aGa>aCa	p.R12729T		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12731	SEA 5.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTGCAGGACTCTCTCTGTGGT	0.532000													26	150					0	0	1	0	0
MCF2L	23263	broad.mit.edu	37	13	113729380	113729380	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr13:113729380G>A	ENST00000397030.1	+	11	1321	c.1284G>A	c.(1282-1284)gcG>gcA	p.A428A	MCF2L_ENST00000421756.1_Silent_p.A399A|MCF2L_ENST00000375601.3_Silent_p.A399A|MCF2L_ENST00000375604.2_Silent_p.A452A|MCF2L_ENST00000423482.2_Silent_p.A393A|MCF2L_ENST00000535094.2_Silent_p.A395A|MCF2L_ENST00000375608.3_Silent_p.A425A|MCF2L_ENST00000434480.2_Silent_p.A401A|MCF2L_ENST00000375597.4_Silent_p.A393A|MCF2L_ENST00000442652.2_Silent_p.A425A			O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming sequence-like	425					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			kidney(1)|large_intestine(5)|ovary(1)|stomach(1)	8	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				AGCACTACGCGGTAGACTCCA	0.657000													28	62					0	0	1	0	0
REG1P	5969	broad.mit.edu	37	2	79364352	79364352	+	RNA	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr2:79364352C>T	ENST00000444841.1	-	0	282																											TCACTCACATCTGCATAAACC	0.537000													14	13					0	0	1	0	0
MYO19	80179	broad.mit.edu	37	17	34869487	34869487	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:34869487C>T	ENST00000431794.3	-	10	1324	c.802G>A	c.(802-804)Gag>Aag	p.E268K	MYO19_ENST00000544606.1_Missense_Mutation_p.E134K|MYO19_ENST00000268852.9_Missense_Mutation_p.E268K|MYO19_ENST00000586007.1_Missense_Mutation_p.E268K	NM_001163735.1	NP_001157207.1	Q96H55	MYO19_HUMAN	myosin XIX	268	Myosin head-like.					mitochondrial outer membrane|myosin complex	actin binding|ATP binding|motor activity			endometrium(6)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|urinary_tract(1)	20		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		AAGCTCCTCTCTGGGTTGGGC	0.602000													8	34					0	0	1	0	0
TRIM8	81603	broad.mit.edu	37	10	104404923	104404923	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:104404923G>T	ENST00000302424.7	+	1	671	c.549G>T	c.(547-549)gaG>gaT	p.E183D		NM_030912.2	NP_112174.2	Q9BZR9	TRIM8_HUMAN	tripartite motif containing 8							cytoplasm|PML body	ligase activity|protein homodimerization activity|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	15		Colorectal(252;0.122)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		GCGACGTGGAGATCCGAAGGA	0.647000													10	11					1.33987e-11	1.4213e-11	1	1	0
ATAD2	29028	broad.mit.edu	37	8	124371897	124371897	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:124371897C>T	ENST00000287394.5	-	10	1293	c.1186G>A	c.(1186-1188)Gaa>Aaa	p.E396K	ATAD2_ENST00000521903.1_5'UTR|ATAD2_ENST00000534257.1_5'UTR	NM_014109.3	NP_054828.2	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	396					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|lung(16)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	48	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			CCTTTTAATTCATCTTTCCGA	0.358000													6	67					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152686043	152686043	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:152686043G>A	ENST00000367255.5	-	63	10685	c.10084C>T	c.(10084-10086)Cag>Tag	p.Q3362*	SYNE1_ENST00000265368.4_Nonsense_Mutation_p.Q3362*|SYNE1_ENST00000341594.5_Nonsense_Mutation_p.Q3401*|SYNE1_ENST00000423061.1_Nonsense_Mutation_p.Q3369*|SYNE1_ENST00000448038.1_Nonsense_Mutation_p.Q3369*	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3362					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTCTGCAGCTGCTGCTGAATA	0.458000										HNSCC(10;0.0054)			37	93					0	0	1	0	0
BAHCC1	57597	broad.mit.edu	37	17	79414364	79414364	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:79414364G>A	ENST00000307745.7	+	15	3466	c.3466G>A	c.(3466-3468)Gaa>Aaa	p.E1156K																								GGGGCTACAAGAACTGCAATG	0.697000													3	10					0	0	1	0	0
CTC1	80169	broad.mit.edu	37	17	8141719	8141719	+	Silent	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:8141719C>G	ENST00000315684.8	-	3	433	c.426G>C	c.(424-426)ctG>ctC	p.L142L	CTC1_ENST00000581671.1_5'UTR	NM_025099.5	NP_079375.3	Q2NKJ3	CTC1_HUMAN	CTS telomere maintenance complex component 1	142					positive regulation of DNA replication|telomere maintenance	Stn1-Ten1 complex	protein binding|single-stranded DNA binding			NS(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(8)|ovary(1)|skin(4)	29						CCTCACAGCTCAGGACGCCAG	0.488000													36	224					0	0	1	0	0
ERBB2	2064	broad.mit.edu	37	17	37868208	37868208	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:37868208C>T	ENST00000406381.2	+	10	1349	c.839C>T	c.(838-840)tCc>tTc	p.S280F	ERBB2_ENST00000269571.5_Missense_Mutation_p.S310F|ERBB2_ENST00000541774.1_Missense_Mutation_p.S295F|ERBB2_ENST00000584450.1_Missense_Mutation_p.S310F|ERBB2_ENST00000540042.1_Missense_Mutation_p.S280F|ERBB2_ENST00000578199.1_Missense_Mutation_p.S280F|ERBB2_ENST00000584601.1_Missense_Mutation_p.S280F|ERBB2_ENST00000445658.2_Missense_Mutation_p.S34F|ERBB2_ENST00000540147.1_Missense_Mutation_p.S280F	NM_001005862.1	NP_001005862.1	P04626	ERBB2_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	310					cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.S310F(6)|p.S310Y(1)		NS(1)|breast(16)|central_nervous_system(17)|endometrium(6)|haematopoietic_and_lymphoid_tissue(8)|kidney(4)|large_intestine(16)|liver(3)|lung(125)|ovary(18)|pancreas(1)|prostate(4)|skin(1)|stomach(14)|upper_aerodigestive_tract(9)|urinary_tract(4)	247	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	GACGTGGGATCCTGCACCCTC	0.582000		1	"""A, Mis, O"""		"""breast, ovarian, other tumour types, NSCLC, gastric"""					TCGA GBM(5;<1E-08)			101	153					0	0	1	0	0
ZNF131	7690	broad.mit.edu	37	5	43122240	43122240	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:43122240G>C	ENST00000509634.1	+	1	541	c.85G>C	c.(85-87)Gag>Cag	p.E29Q	ZNF131_ENST00000509931.1_Missense_Mutation_p.E29Q|ZNF131_ENST00000399534.1_Missense_Mutation_p.E29Q|ZNF131_ENST00000505606.2_Missense_Mutation_p.E29Q|ZNF131_ENST00000306938.4_Missense_Mutation_p.E29Q|ZNF131_ENST00000509156.1_Missense_Mutation_p.E29Q			P52739	ZN131_HUMAN	zinc finger protein 131	29						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	17						TGAACAGCGAGAGCAGGACCG	0.517000													89	88					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578457	7578457	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:7578457C>T	ENST00000420246.2	-	5	605	c.473G>A	c.(472-474)cGc>cAc	p.R158H	TP53_ENST00000455263.2_Missense_Mutation_p.R158H|TP53_ENST00000269305.4_Missense_Mutation_p.R158H|TP53_ENST00000359597.4_Missense_Mutation_p.R158H|TP53_ENST00000445888.2_Missense_Mutation_p.R158H|TP53_ENST00000413465.2_Missense_Mutation_p.R158H	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	158	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		R -> C (in sporadic cancers; somatic mutation).|R -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R158L(77)|p.R158H(74)|p.R158P(9)|p.R65L(8)|p.0?(8)|p.R26L(8)|p.R158fs(6)|p.R158fs*11(6)|p.R65H(5)|p.R26H(5)|p.R158_A159insX(4)|p.R65fs(2)|p.R158_A159delRA(2)|p.R156_I162delRVRAMAI(2)|p.V157fs*9(2)|p.P153fs*22(2)|p.R26fs(2)|p.V157fs*22(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.R158F(1)|p.P151_V173del23(1)|p.R156_R158delRVR(1)|p.R156fs*18(1)|p.R26fs*11(1)|p.R156_A161del(1)|p.V157_M160delVRAM(1)|p.V157_R158delVR(1)|p.S149fs*72(1)|p.A159fs*21(1)|p.T155_A161delTRVRAMA(1)|p.G154fs*22(1)|p.R65fs*11(1)|p.R156fs*20(1)|p.R158C(1)|p.V157_I162delVRAMAI(1)|p.V157fs*21(1)|p.R158fs*8(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCCATGGCGCGGACGCGGGT	0.627000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			17	25					0	0	1	0	0
PLCL2	23228	broad.mit.edu	37	3	17051752	17051752	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr3:17051752C>T	ENST00000418129.2	+	2	1001	c.536C>T	c.(535-537)aCg>aTg	p.T179M	PLCL2_ENST00000432376.1_Missense_Mutation_p.T179M|PLCL2_ENST00000460467.1_Intron|PLCL2_ENST00000396755.2_Missense_Mutation_p.T179M	NM_001144382.1	NP_001137854.1	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2	305	PH.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	43						GGTTTAAAAACGAGCAAAATT	0.348000													30	83					0	0	1	0	0
SEZ6L2	26470	broad.mit.edu	37	16	29900017	29900017	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:29900017G>A	ENST00000308713.5	-	6	1410	c.883C>T	c.(883-885)Cgg>Tgg	p.R295W	SEZ6L2_ENST00000537485.1_Missense_Mutation_p.R251W|SEZ6L2_ENST00000346932.5_Missense_Mutation_p.R181W|SEZ6L2_ENST00000350527.3_Missense_Mutation_p.R225W|SEZ6L2_ENST00000562159.1_5'UTR	NM_001114099.2|NM_201575.3	NP_001107571.1|NP_963869.2	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2	295	Sushi 1.					endoplasmic reticulum membrane|integral to membrane|plasma membrane				breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						TGGGCCGGCCGGGGAGGGAAG	0.642000													23	30					0	0	1	0	0
SLC5A7	60482	broad.mit.edu	37	2	108626840	108626840	+	Silent	SNP	T	T	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr2:108626840T>C	ENST00000264047.2	+	9	1542	c.1266T>C	c.(1264-1266)ctT>ctC	p.L422L	SLC5A7_ENST00000540517.1_Silent_p.L317L|SLC5A7_ENST00000409059.1_Silent_p.L422L	NM_021815.2	NP_068587.1	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (sodium/choline cotransporter), member 7	422					acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(23)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	49					Choline(DB00122)	CCCAGCTGCTTTGTGTACTCT	0.498000													53	45					0	0	1	0	0
SPON1	10418	broad.mit.edu	37	11	14276159	14276159	+	RNA	SNP	T	T	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:14276159T>A	ENST00000310358.7	+	0	1511							Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein						cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		TAGTCCCGACTGGAACGTAGG	0.542000													14	42					0	0	1	0	0
SAE1	10055	broad.mit.edu	37	19	47706939	47706939	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:47706939C>T	ENST00000270225.7	+	8	958	c.890C>T	c.(889-891)tCc>tTc	p.S297F	SAE1_ENST00000598840.1_Missense_Mutation_p.S216F|SAE1_ENST00000392776.3_Missense_Mutation_p.P249S|SAE1_ENST00000413379.3_Intron|SAE1_ENST00000540850.1_Missense_Mutation_p.S123F	NM_005500.2	NP_005491.1	Q9UBE0	SAE1_HUMAN	SUMO1 activating enzyme subunit 1	297					protein sumoylation|protein ubiquitination	nucleus	ATP-dependent protein binding|enzyme activator activity|ligase activity|protein C-terminus binding|protein heterodimerization activity|ubiquitin activating enzyme activity			endometrium(3)|large_intestine(5)|lung(4)|ovary(1)	13		all_cancers(25;1.13e-05)|all_lung(116;0.000192)|all_epithelial(76;0.000274)|Lung NSC(112;0.000446)|all_neural(266;0.0652)|Ovarian(192;0.15)		all cancers(93;0.00013)|OV - Ovarian serous cystadenocarcinoma(262;0.000146)|Epithelial(262;0.00697)|GBM - Glioblastoma multiforme(486;0.0278)		TACTGCTTCTCCGAGATGGCC	0.463000													78	42					0	0	1	0	0
TRAV19	28664	broad.mit.edu	37	14	22476318	22476318	+	RNA	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr14:22476318G>A	ENST00000390447.3	+	0	365																											ATAAGTGGTCGGTATTCTTGG	0.423000													16	13					0	0	1	0	0
ACACB	32	broad.mit.edu	37	12	109702055	109702055	+	Missense_Mutation	SNP	A	A	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:109702055A>G	ENST00000338432.7	+	50	6925	c.6806A>G	c.(6805-6807)gAc>gGc	p.D2269G	ACACB_ENST00000377854.5_Missense_Mutation_p.D2199G|ACACB_ENST00000543201.1_3'UTR|ACACB_ENST00000377848.3_Missense_Mutation_p.D2269G			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	2269	Carboxyltransferase.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	GATCTCTCCGACAAGGACCGA	0.552000											OREG0022102	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	33	123					0	0	1	0	0
RNASE4	6038	broad.mit.edu	37	14	21167916	21167916	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr14:21167916G>C	ENST00000555835.1	+	2	1062	c.386G>C	c.(385-387)aGa>aCa	p.R129T	AL163636.6_ENST00000553909.1_3'UTR|RNASE4_ENST00000397995.2_Missense_Mutation_p.R129T|RP11-903H12.3_ENST00000554286.1_RNA|RNASE4_ENST00000304704.4_Missense_Mutation_p.R129T|RNASE4_ENST00000555597.1_Missense_Mutation_p.R129T	NM_002937.3	NP_002928.1	P34096	RNAS4_HUMAN	ribonuclease, RNase A family, 4	129					mRNA cleavage	extracellular region	nucleic acid binding|pancreatic ribonuclease activity			central_nervous_system(1)|large_intestine(1)|lung(3)|skin(1)	6	all_cancers(95;0.00304)		Epithelial(56;5.13e-07)|all cancers(55;4.73e-06)	GBM - Glioblastoma multiforme(265;0.0133)		GCGAGCACTAGACGTGTTGTC	0.527000													88	104					0	0	1	0	0
RTP2	344892	broad.mit.edu	37	3	187419823	187419823	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr3:187419823C>T	ENST00000358241.1	-	1	522	c.94G>A	c.(94-96)Gac>Aac	p.D32N		NM_001004312.2	NP_001004312.2	Q5QGT7	RTP2_HUMAN	receptor (chemosensory) transporter protein 2	32					protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding			large_intestine(3)|lung(14)|skin(1)	18	all_cancers(143;4.06e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0515)		AGGTTGGGGTCTATGATGAGC	0.577000													38	181					0	0	1	0	0
KCNU1	157855	broad.mit.edu	37	8	36644853	36644853	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:36644853G>A	ENST00000399881.3	+	2	262	c.225G>A	c.(223-225)agG>agA	p.R75R		NM_001031836.2	NP_001027006.2	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	75						voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(31)|ovary(1)|urinary_tract(1)	57				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		CCATCGCTAGGAGCCATGTAA	0.428000													8	17					0	0	1	0	0
SLC12A5	57468	broad.mit.edu	37	20	44676189	44676189	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr20:44676189C>G	ENST00000243964.3	+	15	1982	c.1884C>G	c.(1882-1884)atC>atG	p.I628M	SLC12A5_ENST00000454036.2_Missense_Mutation_p.I651M	NM_020708.4	NP_065759.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	651					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	CTGGACTCATCTACAAGTACA	0.572000													18	156					0	0	1	0	0
ACOT12	134526	broad.mit.edu	37	5	80640791	80640791	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:80640791G>A	ENST00000307624.3	-	8	871	c.843C>T	c.(841-843)atC>atT	p.I281I		NM_130767.2	NP_570123.1	Q8WYK0	ACO12_HUMAN	acyl-CoA thioesterase 12	281	Acyl coenzyme A hydrolase 2.				acyl-CoA metabolic process|fatty acid metabolic process	cytosol	acetyl-CoA hydrolase activity|carboxylesterase activity			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(2)	23		Lung NSC(167;0.0176)|all_lung(232;0.0205)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;1.37e-45)|Epithelial(54;1.25e-39)|all cancers(79;5.01e-34)		AAGCACTGTTGATGTGACGCC	0.493000													44	46					0	0	1	0	0
MSX2	4488	broad.mit.edu	37	5	174156555	174156555	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:174156555C>T	ENST00000239243.6	+	2	900	c.773C>T	c.(772-774)cCa>cTa	p.P258L		NM_002449.4	NP_002440.2	P35548	MSX2_HUMAN	msh homeobox 2	258					cranial suture morphogenesis|negative regulation of transcription, DNA-dependent|osteoblast differentiation	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)	10	Renal(175;0.000159)|Lung NSC(126;0.0196)|all_lung(126;0.0303)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			TATGCCACGCCAGTGGGATAT	0.547000													27	58					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238277740	238277740	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr2:238277740G>A	ENST00000295550.4	-	10	4818	c.4366C>T	c.(4366-4368)Cga>Tga	p.R1456*	COL6A3_ENST00000353578.4_Nonsense_Mutation_p.R1250*|COL6A3_ENST00000347401.3_Nonsense_Mutation_p.R1255*|COL6A3_ENST00000346358.4_Nonsense_Mutation_p.R1256*|COL6A3_ENST00000472056.1_Nonsense_Mutation_p.R849*|COL6A3_ENST00000409809.1_Nonsense_Mutation_p.R1250*	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	1456	Nonhelical region.|VWFA 8.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		ACAAAATCTCGAATATGTGCA	0.458000													21	15					0	0	1	0	0
NALCN	259232	broad.mit.edu	37	13	101944717	101944717	+	Splice_Site	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr13:101944717C>G	ENST00000251127.6	-	8	881	c.800G>C	c.(799-801)gGa>gCa	p.G267A	NALCN_ENST00000470333.1_5'UTR|NALCN_ENST00000376196.3_Splice_Site_p.G267A	NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	267						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TATACTAGTTCCTGTCATGAC	0.433000													23	28					0	0	1	0	0
KIAA1755	85449	broad.mit.edu	37	20	36870149	36870149	+	Silent	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr20:36870149G>C	ENST00000279024.4	-	3	655	c.384C>G	c.(382-384)ctC>ctG	p.L128L		NM_001029864.1	NP_001025035.1	Q5JYT7	K1755_HUMAN	KIAA1755	128										breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(5)|pancreas(2)|skin(4)|stomach(1)	54		Myeloproliferative disorder(115;0.00874)				CCACTGTGCAGAGGTCCAGGG	0.537000													42	135					0	0	1	0	0
SYT15	83849	broad.mit.edu	37	10	46967428	46967428	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:46967428G>A	ENST00000374323.4	-	3	1395	c.808C>T	c.(808-810)Cag>Tag	p.Q270*	SYT15_ENST00000374321.4_Nonsense_Mutation_p.Q217*|SYT15_ENST00000374325.3_Nonsense_Mutation_p.Q217*|SYT15_ENST00000503753.1_Nonsense_Mutation_p.Q217*			Q9BQS2	SYT15_HUMAN	synaptotagmin XV							integral to membrane|plasma membrane				cervix(1)|endometrium(5)|kidney(2)|lung(5)	13						GGCTGTACCTGAAAGATGAAG	0.602000													7	67					0	0	1	0	0
DNAJC14	85406	broad.mit.edu	37	12	56216185	56216185	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:56216185G>A	ENST00000357606.3	-	7	2159	c.1870C>T	c.(1870-1872)Cgg>Tgg	p.R624W	RP11-762I7.5_ENST00000546837.1_Missense_Mutation_p.S253L|DNAJC14_ENST00000317287.5_Missense_Mutation_p.R624W|RP11-762I7.5_ENST00000552719.1_5'UTR|DNAJC14_ENST00000317269.3_Missense_Mutation_p.R624W			Q6Y2X3	DJC14_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 14	624					protein folding|protein transport	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|unfolded protein binding			breast(2)|kidney(1)|large_intestine(8)|lung(7)|ovary(3)|prostate(1)|skin(1)	23						CCTGGAATCCGAGAACCAAAT	0.453000											OREG0021910	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	87					0	0	1	0	0
RASEF	158158	broad.mit.edu	37	9	85613323	85613323	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr9:85613323C>G	ENST00000376447.3	-	13	2022	c.1762G>C	c.(1762-1764)Gaa>Caa	p.E588Q		NM_152573.2	NP_689786.2	Q8IZ41	RASEF_HUMAN	RAS and EF-hand domain containing	588					protein transport|small GTPase mediated signal transduction	perinuclear region of cytoplasm	calcium ion binding|GTP binding			NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(4)|liver(1)|lung(15)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	33						ACTGTTCGTTCTCCATCCACA	0.453000													179	84					0	0	1	0	0
AQP6	363	broad.mit.edu	37	12	50368531	50368531	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:50368531C>T	ENST00000315520.5	+	3	901	c.564C>T	c.(562-564)atC>atT	p.I188I	AQP6_ENST00000551733.1_Silent_p.I14I	NM_001652.3	NP_001643.2	Q13520	AQP6_HUMAN	aquaporin 6, kidney specific	188					excretion|odontogenesis	integral to plasma membrane|transport vesicle membrane	anion channel activity|water channel activity			endometrium(1)|large_intestine(2)|lung(7)|pancreas(1)|skin(2)	13						CTCCCCAGATCCACTTCACTG	0.607000											OREG0021809	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	33	21					0	0	1	0	0
CTAGE1	64693	broad.mit.edu	37	18	19995722	19995722	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr18:19995722C>T	ENST00000391403.2	-	1	2156	c.2053G>A	c.(2053-2055)Gga>Aga	p.G685R		NM_172241.2	NP_758441.2	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	685	Pro-rich.					integral to membrane				cervix(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(19)|ovary(1)	27	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					AAAGGAGGTCCTCTTCTTATG	0.507000													73	122					0	0	1	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140348520	140348520	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:140348520C>T	ENST00000289269.5	+	1	2701	c.2169C>T	c.(2167-2169)atC>atT	p.I723I	PCDHA10_ENST00000506939.2_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHAC1_ENST00000253807.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA7_ENST00000525929.1_Intron	NM_018899.5|NM_031883.2	NP_061722.1|NP_114089.1	Q9Y5I4	PCDC2_HUMAN		723					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTTTGACAATCATCATTTTGA	0.433000													14	85					0	0	1	0	0
EXOC3	11336	broad.mit.edu	37	5	464494	464494	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:464494C>T	ENST00000512944.1	+	10	1932	c.1743C>T	c.(1741-1743)aaC>aaT	p.N581N	EXOC3_ENST00000315013.5_Silent_p.N581N	NM_007277.4	NP_009208.2	O60645	EXOC3_HUMAN	exocyst complex component 3	592					exocytosis|protein transport					breast(2)|cervix(1)|endometrium(4)|large_intestine(1)|lung(13)|ovary(1)|urinary_tract(1)	23		Ovarian(839;0.0563)	Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			ACTATTTCAACGATTTTGCCA	0.443000													19	209					0	0	1	0	0
GLUD1P7	414212	broad.mit.edu	37	10	48968566	48968566	+	RNA	SNP	A	A	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:48968566A>G	ENST00000594520.1	+	0	723																											ACAGGATAACAAACTGGAAAA	0.318000													3	24					0	0	1	0	0
TMEM139	135932	broad.mit.edu	37	7	142983872	142983872	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:142983872C>T	ENST00000359333.3	+	3	1114	c.601C>T	c.(601-603)Cac>Tac	p.H201Y	TMEM139_ENST00000409102.1_Missense_Mutation_p.H201Y|TMEM139_ENST00000410004.1_Missense_Mutation_p.H201Y|TMEM139_ENST00000409244.1_Missense_Mutation_p.H201Y|AC073342.12_ENST00000446192.1_RNA|TMEM139_ENST00000409541.1_Missense_Mutation_p.H201Y|TMEM139_ENST00000471161.1_3'UTR	NM_001242775.2|NM_001282876.1|NM_001282877.1	NP_001229704.1|NP_001269805.1|NP_001269806.1	Q8IV31	TM139_HUMAN	transmembrane protein 139	201						integral to membrane				endometrium(1)|lung(4)|ovary(1)|prostate(1)	7	Melanoma(164;0.059)					CTGCTTTGGTCACCCTGATGA	0.522000													70	67					0	0	1	0	0
MOCOS	55034	broad.mit.edu	37	18	33800081	33800081	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr18:33800081C>T	ENST00000261326.5	+	9	1882	c.1861C>T	c.(1861-1863)Cac>Tac	p.H621Y		NM_017947.2	NP_060417.2	Q96EN8	MOCOS_HUMAN	molybdenum cofactor sulfurase	621					Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	lyase activity|Mo-molybdopterin cofactor sulfurase activity|molybdenum ion binding|pyridoxal phosphate binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(10)|liver(1)|lung(15)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	43					Pyridoxal Phosphate(DB00114)	GGTTGTGAATCACAATGGTGT	0.537000													23	30					0	0	1	0	0
PPP1R12B	4660	broad.mit.edu	37	1	202549682	202549682	+	Silent	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:202549682C>G	ENST00000608999.1	+	24	3096	c.2943C>G	c.(2941-2943)tcC>tcG	p.S981S	PPP1R12B_ENST00000290419.5_3'UTR|PPP1R12B_ENST00000367270.4_3'UTR|PPP1R12B_ENST00000336894.4_Silent_p.S981S|PPP1R12B_ENST00000391959.3_Silent_p.S207S	NM_001197131.1|NM_002481.3	NP_001184060.1|NP_002472.2	O60237	MYPT2_HUMAN	protein phosphatase 1, regulatory subunit 12B						regulation of muscle contraction|signal transduction	cytoplasm	enzyme activator activity			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(7)|lung(17)|ovary(4)|skin(3)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(75;0.166)			GCAAACTGTCCAAGTAGGCTA	0.478000													44	28					0	0	1	0	0
LIMCH1	22998	broad.mit.edu	37	4	41668680	41668680	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr4:41668680C>G	ENST00000313860.7	+	16	2293	c.2239C>G	c.(2239-2241)Caa>Gaa	p.Q747E	LIMCH1_ENST00000513024.1_Missense_Mutation_p.Q576E|LIMCH1_ENST00000512820.1_Missense_Mutation_p.Q735E|LIMCH1_ENST00000512946.1_Missense_Mutation_p.Q747E|LIMCH1_ENST00000503057.1_Missense_Mutation_p.Q1132E|LIMCH1_ENST00000381753.4_Missense_Mutation_p.Q581E|LIMCH1_ENST00000514096.1_Missense_Mutation_p.Q588E|LIMCH1_ENST00000508501.1_Missense_Mutation_p.Q747E|LIMCH1_ENST00000509277.1_Missense_Mutation_p.Q581E|LIMCH1_ENST00000512632.1_Intron|LIMCH1_ENST00000396595.3_Missense_Mutation_p.Q593E|LIMCH1_ENST00000511496.1_Missense_Mutation_p.Q588E	NM_014988.2	NP_055803.2	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1	747					actomyosin structure organization		actin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(5)	41						TCTCAATTCTCAAGGTAAAGA	0.393000													9	40					0	0	1	0	0
ZNF714	148206	broad.mit.edu	37	19	21300143	21300143	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:21300143G>C	ENST00000596143.1	+	5	998	c.673G>C	c.(673-675)Gag>Cag	p.E225Q	ZNF714_ENST00000596053.1_Intron|ZNF714_ENST00000601416.1_3'UTR|ZNF714_ENST00000291770.7_3'UTR	NM_182515.3	NP_872321	Q96N38	ZN714_HUMAN	zinc finger protein 714	226					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(3)|lung(11)|urinary_tract(2)	18						TCATACTGGAGAGAAACCCTA	0.408000													5	68					0	0	1	0	0
PDZK1	5174	broad.mit.edu	37	1	145747150	145747150	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:145747150G>T	ENST00000344770.2	+	2	180	c.107G>T	c.(106-108)cGg>cTg	p.R36L	PDZK1_ENST00000451928.2_Missense_Mutation_p.R36L|PDZK1_ENST00000417171.1_Missense_Mutation_p.R36L	NM_002614.4	NP_002605.2	Q5T2W1	NHRF3_HUMAN	PDZ domain containing 1	36	PDZ 1.				carnitine transport|cell proliferation|drug transport|positive regulation of ion transmembrane transport	brush border membrane|cytoplasm	PDZ domain binding|transporter activity			NS(1)|endometrium(1)|large_intestine(1)|lung(3)|pancreas(1)	7	all_hematologic(18;0.00473)|Acute lymphoblastic leukemia(18;0.0786)		KIRC - Kidney renal clear cell carcinoma(6;0.0764)|Kidney(552;0.118)|Colorectal(543;0.229)			CACCTGGTCCGGGTGGTTGAG	0.502000													22	491					1.10923e-09	1.16697e-09	1	1	0
ADCYAP1	116	broad.mit.edu	37	18	907685	907685	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr18:907685G>C	ENST00000579794.1	+	2	414	c.136G>C	c.(136-138)Gac>Cac	p.D46H	ADCYAP1_ENST00000450565.3_Missense_Mutation_p.D46H	NM_001117.3	NP_001108.2	P18509	PACA_HUMAN	adenylate cyclase activating polypeptide 1 (pituitary)	46					activation of adenylate cyclase activity|cell-cell signaling|female pregnancy|nerve growth factor receptor signaling pathway|regulation of G-protein coupled receptor protein signaling pathway	extracellular region|soluble fraction	neuropeptide hormone activity|peptide hormone receptor binding			endometrium(1)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)	12						GTACGGCGAGGACGGAAACCC	0.731000													2	5					0	0	1	0	0
PIGO	84720	broad.mit.edu	37	9	35094310	35094310	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr9:35094310G>A	ENST00000378617.3	-	3	952	c.558C>T	c.(556-558)ttC>ttT	p.F186F	PIGO_ENST00000298004.5_Silent_p.F186F|PIGO_ENST00000341666.3_Silent_p.F186F|PIGO_ENST00000361778.2_Silent_p.F186F	NM_032634.3	NP_116023.2	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class O	186					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			endometrium(3)|kidney(2)|large_intestine(8)|lung(13)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)	38			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			AAGCACCAGGGAAAAGGTCTT	0.502000													20	31					0	0	1	0	0
CHST7	56548	broad.mit.edu	37	X	46433799	46433799	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chrX:46433799G>A	ENST00000276055.3	+	1	581	c.433G>A	c.(433-435)Gac>Aac	p.D145N		NM_019886.2	NP_063939.2	Q9NS84	CHST7_HUMAN	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7	145					chondroitin sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	chondroitin 6-sulfotransferase activity|N-acetylglucosamine 6-O-sulfotransferase activity			breast(3)|endometrium(2)|kidney(1)|lung(2)	8						GTATCCGGGCGACGCCGAGAG	0.657000													33	16					0	0	1	0	0
ZNF37BP	100129482	broad.mit.edu	37	10	43016561	43016561	+	RNA	SNP	T	T	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:43016561T>A	ENST00000452075.3	-	0	1033					NR_026777.1																						TAGTTTCTACTGGTATTAATT	0.308000													19	50					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57327167	57327167	+	Silent	SNP	A	A	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:57327167A>G	ENST00000326441.9	-	10	3006	c.2643T>C	c.(2641-2643)ccT>ccC	p.P881P	ZIM2_ENST00000593711.1_Intron|PEG3_ENST00000593695.1_Silent_p.P755P|ZIM2_ENST00000601070.1_Intron|PEG3_ENST00000423103.2_Silent_p.P881P|PEG3_ENST00000598410.1_Silent_p.P757P|ZIM2_ENST00000391708.3_Intron|ZIM2_ENST00000599935.1_Intron|ZIM2_ENST00000221722.5_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	881					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CCCCTTCACAAGGGTTCTCTC	0.443000													24	110					0	0	1	0	0
SMPD4P1	645280	broad.mit.edu	37	22	20970648	20970648	+	RNA	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr22:20970648C>T	ENST00000443839.1	-	0	1976																											GGTCTGCATTCACAGACATCT	0.557000													4	29					0	0	1	0	0
SENP5	205564	broad.mit.edu	37	3	196612107	196612107	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr3:196612107G>C	ENST00000323460.5	+	2	304	c.55G>C	c.(55-57)Gag>Cag	p.E19Q	SENP5_ENST00000419026.1_Intron|SENP5_ENST00000445299.2_Missense_Mutation_p.E19Q	NM_152699.4	NP_689912.2	Q96HI0	SENP5_HUMAN	SUMO1/sentrin specific peptidase 5	19					cell cycle|cell division|proteolysis	nucleolus	cysteine-type peptidase activity			NS(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(9)|lung(14)|skin(1)	32	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;3.14e-24)|all cancers(36;2.1e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.004)		AGCCTTTTCTGAGAAATGGAA	0.383000													24	76					0	0	1	0	0
GRIK2	2898	broad.mit.edu	37	6	102483434	102483434	+	Silent	SNP	T	T	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:102483434T>C	ENST00000369138.1	+	14	2794	c.2304T>C	c.(2302-2304)acT>acC	p.T768T	GRIK2_ENST00000318991.6_Silent_p.T768T|GRIK2_ENST00000369137.3_Silent_p.T692T|GRIK2_ENST00000421544.1_Silent_p.T768T|GRIK2_ENST00000413795.1_Silent_p.T768T|GRIK2_ENST00000369134.4_Silent_p.T719T	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	768					glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	GCGTTGGCACTCCCATGGGTA	0.443000													47	134					0	0	1	0	0
SMURF1	57154	broad.mit.edu	37	7	98645441	98645441	+	Missense_Mutation	SNP	C	C	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:98645441C>A	ENST00000361125.1	-	11	1415	c.1096G>T	c.(1096-1098)Gac>Tac	p.D366Y	AC004893.11_ENST00000468960.2_RNA|AC004893.11_ENST00000482799.2_RNA|SMURF1_ENST00000361368.2_Missense_Mutation_p.D340Y	NM_020429.2	NP_065162.1	Q9HCE7	SMUF1_HUMAN	SMAD specific E3 ubiquitin protein ligase 1	366					BMP signaling pathway|cell differentiation|ectoderm development|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein export from nucleus|protein localization at cell surface|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|plasma membrane	activin binding|I-SMAD binding|R-SMAD binding|ubiquitin-protein ligase activity			endometrium(3)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|skin(2)|urinary_tract(1)	25	all_cancers(62;1.05e-08)|all_epithelial(64;4.34e-09)|Lung NSC(181;0.00902)|all_lung(186;0.0145)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)|Lung(104;0.224)			AGCTCCTCGTCCTCCAGAGAG	0.562000													69	290					1.52378e-38	1.69603e-38	1	1	0
VARS2	57176	broad.mit.edu	37	6	30884992	30884992	+	Silent	SNP	G	G	A	rs59234326	by1000genomes	TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:30884992G>A	ENST00000321897.5	+	8	1496	c.864G>A	c.(862-864)tcG>tcA	p.S288S	VARS2_ENST00000542001.1_Silent_p.S148S|VARS2_ENST00000541562.1_Silent_p.S318S|VARS2_ENST00000416670.2_Silent_p.S288S			Q5ST30	SYVM_HUMAN	valyl-tRNA synthetase 2, mitochondrial	288					valyl-tRNA aminoacylation	mitochondrion	ATP binding|valine-tRNA ligase activity			central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(15)|ovary(3)|prostate(3)|skin(4)|urinary_tract(1)	46						CAGCCATCTCGGACATTGAGG	0.542000													105	119					0	0	1	0	0
FOXE3	2301	broad.mit.edu	37	1	47882467	47882467	+	Silent	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:47882467C>T	ENST00000335071.2	+	1	724	c.480C>T	c.(478-480)ttC>ttT	p.F160F		NM_012186.2	NP_036318.1	Q13461	FOXE3_HUMAN	forkhead box E3	160					cell migration|embryonic organ morphogenesis|enteric nervous system development|hair follicle morphogenesis|hard palate development|lens morphogenesis in camera-type eye|pattern specification process|positive regulation of epithelial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|soft palate development|thyroid gland development|thyroid hormone generation	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			lung(3)|prostate(1)|upper_aerodigestive_tract(1)	5				READ - Rectum adenocarcinoma(2;0.0908)		ACGGCAGCTTCCTGCGGCGCC	0.746000													35	21					0	0	1	0	0
WRN	7486	broad.mit.edu	37	8	30933803	30933803	+	Splice_Site	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:30933803G>A	ENST00000298139.5	+	8	1088	c.839G>A	c.(838-840)aGg>aAg	p.R280K		NM_000553.4	NP_000544.2	Q14191	WRN_HUMAN	Werner syndrome, RecQ helicase-like	280					base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			central_nervous_system(2)|endometrium(4)|kidney(4)|large_intestine(13)|lung(28)|ovary(3)|skin(3)|upper_aerodigestive_tract(3)	60		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		AACCCACGGAGGTTAAATATT	0.328000			"""Mis, N, F, S"""			"""osteosarcoma, meningioma, others"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Werner syndrome				28	30					0	0	1	0	0
ZFR2	23217	broad.mit.edu	37	19	3819086	3819086	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:3819086C>T	ENST00000262961.4	-	12	1898	c.1888G>A	c.(1888-1890)Gag>Aag	p.E630K		NM_015174.1	NP_055989.1	Q9UPR6	ZFR2_HUMAN	zinc finger RNA binding protein 2	630						intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(5)|pancreas(1)|prostate(1)|skin(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00514)|STAD - Stomach adenocarcinoma(1328;0.19)		CGGTCCTCCTCGGCCAGTGTG	0.687000													5	21					0	0	1	0	0
ACHE	43	broad.mit.edu	37	7	100491073	100491073	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:100491073C>T	ENST00000302913.4	-	2	919	c.781G>A	c.(781-783)Ggt>Agt	p.G261S	ACHE_ENST00000419336.2_Missense_Mutation_p.G261S|ACHE_ENST00000428317.1_Missense_Mutation_p.G261S|ACHE_ENST00000411582.1_Missense_Mutation_p.G261S|ACHE_ENST00000241069.5_Missense_Mutation_p.G261S|ACHE_ENST00000412389.1_Missense_Mutation_p.G261S	NM_015831.2	NP_056646.1	P22303	ACES_HUMAN	acetylcholinesterase	261					acetylcholine catabolic process in synaptic cleft|amyloid precursor protein metabolic process|cell adhesion|cell proliferation|choline metabolic process|DNA replication|muscle organ development|neurotransmitter biosynthetic process|osteoblast development|positive regulation of protein secretion|regulation of axonogenesis|regulation of dendrite morphogenesis|response to wounding|synapse assembly	anchored to membrane|axon|basal lamina|cell junction|cell surface|dendrite|endoplasmic reticulum lumen|extracellular space|Golgi apparatus|neuromuscular junction|nucleus|perinuclear region of cytoplasm|postsynaptic membrane|presynaptic membrane|synaptic cleft	acetylcholine binding|acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|collagen binding|laminin-1 binding|protein homodimerization activity|serine hydrolase activity			large_intestine(3)|lung(7)|skin(3)|urinary_tract(3)	16	Lung NSC(181;0.041)|all_lung(186;0.0581)				Ambenonium(DB01122)|Atropine(DB00572)|Choline(DB00122)|Decamethonium(DB01245)|Demecarium bromide(DB00944)|Donepezil(DB00843)|Edrophonium(DB01010)|Ephedrine(DB01364)|Galantamine(DB00674)|Gallamine Triethiodide(DB00483)|Isoflurophate(DB00677)|Neostigmine(DB01400)|Physostigmine(DB00981)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Tacrine(DB00382)|Tubocurarine(DB01199)	TTGGGGGCACCGCTCTGCAGC	0.726000													14	51					0	0	1	0	0
XYLT1	64131	broad.mit.edu	37	16	17211827	17211827	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:17211827C>T	ENST00000261381.6	-	11	2317	c.2233G>A	c.(2233-2235)Gac>Aac	p.D745N		NM_022166.3	NP_071449.1	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	745					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						GCATCCCAGTCAGTGCCGACC	0.547000													11	56					0	0	1	0	0
TCF25	22980	broad.mit.edu	37	16	89952289	89952289	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:89952289G>C	ENST00000263346.8	+	4	519	c.463G>C	c.(463-465)Gag>Cag	p.E155Q	TCF25_ENST00000263347.7_5'UTR	NM_014972.2	NP_055787.1	Q9BQ70	TCF25_HUMAN	transcription factor 25 (basic helix-loop-helix)	155					heart development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|large_intestine(1)|lung(8)|ovary(3)|skin(1)|urinary_tract(2)	18		all_cancers(9;4.71e-08)|Lung NSC(15;0.000192)|all_lung(18;0.000319)|all_neural(9;0.0122)|all_hematologic(23;0.027)		BRCA - Breast invasive adenocarcinoma(80;0.0288)		TCGCATCCTAGAGAGGATTGA	0.498000													48	60					0	0	1	0	0
PSG2	5670	broad.mit.edu	37	19	43585239	43585239	+	Missense_Mutation	SNP	A	A	T	rs142667584		TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:43585239A>T	ENST00000406487.1	-	2	322	c.224T>A	c.(223-225)cTc>cAc	p.L75H		NM_031246.3	NP_112536.2	P11465	PSG2_HUMAN	pregnancy specific beta-1-glycoprotein 2	75	Ig-like V-type.				cell migration|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(24)|ovary(1)|pancreas(2)|prostate(6)|stomach(2)|urinary_tract(2)	49		Prostate(69;0.00682)				GTAATGGTAGAGGTCCCTGAT	0.433000													33	346					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103461433	103461433	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:103461433G>C	ENST00000358392.2	-	28	2680	c.2363C>G	c.(2362-2364)tCt>tGt	p.S788C	COL11A1_ENST00000370096.3_Missense_Mutation_p.S776C|COL11A1_ENST00000353414.4_Missense_Mutation_p.S737C|COL11A1_ENST00000512756.1_Missense_Mutation_p.S660C	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	776	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TTCACCTTTAGATCCCTTGAG	0.269000													18	119					0	0	1	0	0
CENPN	55839	broad.mit.edu	37	16	81045675	81045675	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:81045675G>A	ENST00000305850.5	+	2	921	c.131G>A	c.(130-132)aGa>aAa	p.R44K	CENPN_ENST00000428963.2_Missense_Mutation_p.R44K|CMC2_ENST00000565914.1_Intron|CENPN_ENST00000569461.1_3'UTR|CENPN_ENST00000393335.3_Missense_Mutation_p.R44K|CENPN_ENST00000299572.5_Missense_Mutation_p.R44K|CENPN_ENST00000439957.3_Missense_Mutation_p.R44K	NM_001100624.2|NM_001270474.1	NP_001094094.2|NP_001257403.1	Q96H22	CENPN_HUMAN	centromere protein N	44					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm				breast(1)|large_intestine(5)|lung(4)	10						TTCCGACAGAGAAAGGAATCT	0.418000													11	79					0	0	1	0	0
MEGF8	1954	broad.mit.edu	37	19	42873014	42873014	+	Silent	SNP	G	G	A	rs145990797		TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:42873014G>A	ENST00000334370.4	+	36	6935	c.6300G>A	c.(6298-6300)ccG>ccA	p.P2100P	MEGF8_ENST00000251268.6_Silent_p.P2167P	NM_001410.2	NP_001401.2	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	2167	PSI 6.					integral to membrane	calcium ion binding|structural molecule activity			breast(2)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	50		Prostate(69;0.00682)				GTGGGCGTCCGGGGGCCTCCT	0.642000													68	31					0	0	1	0	0
APPL2	55198	broad.mit.edu	37	12	105593247	105593247	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:105593247G>A	ENST00000258530.3	-	10	992	c.767C>T	c.(766-768)tCt>tTt	p.S256F	APPL2_ENST00000539978.2_Missense_Mutation_p.S213F|APPL2_ENST00000551662.1_Missense_Mutation_p.S262F|APPL2_ENST00000549573.1_5'UTR	NM_001251904.1|NM_018171.3	NP_001238833.1|NP_060641.2	Q8NEU8	DP13B_HUMAN	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2	256	Required for RAB5A binding (By similarity).				cell cycle|cell proliferation|signal transduction	early endosome membrane|nucleus	protein binding			breast(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						TTCATCAACAGAAAGTAATTC	0.473000													40	29					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124348677	124348677	+	Missense_Mutation	SNP	T	T	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:124348677T>A	ENST00000338354.3	+	17	2107	c.2001T>A	c.(1999-2001)gaT>gaA	p.D667E	DMBT1_ENST00000344338.3_Missense_Mutation_p.D657E|DMBT1_ENST00000368955.3_Missense_Mutation_p.D657E|DMBT1_ENST00000330163.4_Intron|DMBT1_ENST00000359586.6_Intron|DMBT1_ENST00000368956.2_Intron|DMBT1_ENST00000368909.3_Missense_Mutation_p.D667E			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	667	SRCR 5.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TTGTCCTGGATGATGTGCGCT	0.587000													110	94					0	0	1	0	0
EDNRA	1909	broad.mit.edu	37	4	148406959	148406959	+	Silent	SNP	C	C	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr4:148406959C>A	ENST00000324300.5	+	2	641	c.126C>A	c.(124-126)ggC>ggA	p.G42G	EDNRA_ENST00000511804.1_Intron|EDNRA_ENST00000506066.1_Silent_p.G42G|EDNRA_ENST00000339690.5_Silent_p.G42G|EDNRA_ENST00000358556.4_Silent_p.G42G	NM_001957.3	NP_001948.1	P25101	EDNRA_HUMAN	endothelin receptor type A	42					activation of adenylate cyclase activity|artery smooth muscle contraction|cell proliferation|glucose transport|respiratory gaseous exchange	integral to plasma membrane	endothelin-A receptor activity|phosphatidylinositol phospholipase C activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(4)|lung(3)|ovary(1)	17	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.154)	Bosentan(DB00559)	CTTTTCGTGGCACAGAGCTCA	0.448000													24	123					4.54149e-19	4.89868e-19	1	1	0
RBM42	79171	broad.mit.edu	37	19	36128214	36128214	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:36128214G>A	ENST00000262633.4	+	9	1395	c.1290G>A	c.(1288-1290)aaG>aaA	p.K430K	RBM42_ENST00000592202.1_Silent_p.K376K|RBM42_ENST00000586618.1_Silent_p.K134K|RBM42_ENST00000588161.1_Silent_p.K400K|RBM42_ENST00000360475.4_Silent_p.K401K|RBM42_ENST00000589871.1_Silent_p.K408K|RBM42_ENST00000589559.1_Intron	NM_024321.3	NP_077297.2	Q9BTD8	RBM42_HUMAN	RNA binding motif protein 42	430	Necessary for interaction with HNRNPK (By similarity).|RRM.					cytoplasm|nucleus	nucleotide binding|RNA binding	p.K430>?(1)		breast(1)|endometrium(3)|large_intestine(7)|lung(9)|prostate(1)	21	all_lung(56;1.58e-07)|Lung NSC(56;2.43e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			TCAGCTTCAAGGACCCCAGCG	0.647000													91	112					0	0	1	0	0
FUBP1	8880	broad.mit.edu	37	1	78429366	78429366	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:78429366C>T	ENST00000370767.1	-	13	1163	c.1076G>A	c.(1075-1077)cGa>cAa	p.R359Q	FUBP1_ENST00000370768.2_Missense_Mutation_p.R359Q|FUBP1_ENST00000436586.2_Missense_Mutation_p.R380Q			Q96AE4	FUBP1_HUMAN	far upstream element (FUSE) binding protein 1	359	Gly-rich.				transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(1)|upper_aerodigestive_tract(3)	17						ACCTCTTCCTCGACCACCAGG	0.428000			"""F, N"""		oligodendroglioma								26	41					0	0	1	0	0
UBE2D3	7323	broad.mit.edu	37	4	103730859	103730859	+	Splice_Site	SNP	C	C	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr4:103730859C>A	ENST00000453744.2	-	4	603	c.90G>T	c.(88-90)atG>atT	p.M30I	UBE2D3_ENST00000504211.1_Splice_Site_p.M1I|UBE2D3_ENST00000350435.7_Splice_Site_p.M24I|UBE2D3_ENST00000338145.3_Splice_Site_p.M30I|UBE2D3_ENST00000357194.6_Splice_Site_p.M32I|UBE2D3_ENST00000505207.1_Splice_Site_p.M1I|UBE2D3_ENST00000507845.1_Splice_Site_p.M1I|UBE2D3_ENST00000513098.1_5'UTR|UBE2D3_ENST00000502404.1_Splice_Site_p.M1I|UBE2D3_ENST00000394803.5_Splice_Site_p.M30I|UBE2D3_ENST00000343106.5_Splice_Site_p.M30I|UBE2D3_ENST00000349311.8_Splice_Site_p.M30I|UBE2D3_ENST00000394801.4_Splice_Site_p.M30I|UBE2D3_ENST00000321805.7_Splice_Site_p.M30I|UBE2D3_ENST00000394804.2_Splice_Site_p.M30I	NM_181891.1	NP_871620.1	P61077	UB2D3_HUMAN	ubiquitin-conjugating enzyme E2D 3	30					apoptosis|BMP signaling pathway|DNA repair|negative regulation of type I interferon production|proteasomal ubiquitin-dependent protein catabolic process|protein K11-linked ubiquitination|protein K48-linked ubiquitination|protein monoubiquitination|transforming growth factor beta receptor signaling pathway	endosome membrane|plasma membrane	ATP binding|protein binding|ubiquitin-protein ligase activity			kidney(1)|lung(3)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.13e-08)		GCCAATGAAACACTAGAAAAA	0.284000													7	40					0.000157383	0.000160732	1	1	0
EEF1A2	1917	broad.mit.edu	37	20	62121972	62121972	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr20:62121972C>T	ENST00000217182.3	-	6	1054	c.889G>A	c.(889-891)Gag>Aag	p.E297K	EEF1A2_ENST00000298049.7_Missense_Mutation_p.E297K	NM_001958.3	NP_001949.1	Q05639	EF1A2_HUMAN	eukaryotic translation elongation factor 1 alpha 2	297						nucleus	GTP binding|GTPase activity|protein binding|translation elongation factor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(14)|stomach(1)	20	all_cancers(38;9.45e-12)		BRCA - Breast invasive adenocarcinoma(10;1.22e-05)			CTCAGAGCCTCGTGGTGCATC	0.627000													38	104					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139380157	139380157	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:139380157G>C	ENST00000395297.1	-	2	240	c.70C>G	c.(70-72)Cag>Gag	p.Q24E		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	24										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TACCCTCTCTGAAAGAGATCC	0.393000										HNSCC(54;0.14)			57	34					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56392885	56392885	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:56392885G>C	ENST00000301295.6	+	10	3339	c.2917G>C	c.(2917-2919)Gag>Cag	p.E973Q	NLRP4_ENST00000346986.5_Missense_Mutation_p.E917Q|NLRP4_ENST00000587891.1_Missense_Mutation_p.E898Q	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	973							ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		TCTGACGGCTGAGGAAGAGAG	0.433000													32	21					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39799983	39799983	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:39799983C>T	ENST00000564288.1	+	37	8500	c.7723C>T	c.(7723-7725)Cag>Tag	p.Q2575*	MACF1_ENST00000361689.2_Intron|MACF1_ENST00000289893.4_Nonsense_Mutation_p.Q1015*|MACF1_ENST00000476350.1_Intron|MACF1_ENST00000317713.7_Intron|MACF1_ENST00000567887.1_Nonsense_Mutation_p.Q2612*|MACF1_ENST00000372915.3_Nonsense_Mutation_p.Q2580*|MACF1_ENST00000545844.1_Intron|MACF1_ENST00000539005.1_Intron			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	2580					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AAGAGAAATCCAGGAGGTTCA	0.378000													92	39					0	0	1	0	0
LDLRAD3	143458	broad.mit.edu	37	11	36248840	36248840	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:36248840G>A	ENST00000315571.5	+	5	681	c.660G>A	c.(658-660)ctG>ctA	p.L220L	LDLRAD3_ENST00000524419.1_Silent_p.L210L|LDLRAD3_ENST00000529759.1_3'UTR|LDLRAD3_ENST00000528989.1_Silent_p.L171L	NM_174902.2	NP_777562.1	Q86YD5	LRAD3_HUMAN	low density lipoprotein receptor class A domain containing 3	220						integral to membrane	receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(14)|prostate(7)|skin(1)	28	all_lung(20;0.089)|Lung NSC(22;0.175)|all_epithelial(35;0.177)	all_hematologic(20;0.124)				TGTCCCGCCTGGTGGTCCTGG	0.627000													34	41					0	0	1	0	0
EFCAB1	79645	broad.mit.edu	37	8	49637345	49637345	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:49637345C>T	ENST00000433756.1	-	5	595	c.436G>A	c.(436-438)Gaa>Aaa	p.E146K	EFCAB1_ENST00000521002.1_Intron|EFCAB1_ENST00000523092.1_Missense_Mutation_p.E146K|EFCAB1_ENST00000262103.3_Missense_Mutation_p.E198K	NM_001142857.1	NP_001136329.1	Q9HAE3	EFCB1_HUMAN	EF-hand calcium binding domain 1	198	EF-hand 3.						calcium ion binding			endometrium(1)|large_intestine(3)|lung(6)|pancreas(1)|prostate(1)|urinary_tract(2)	14		all_epithelial(80;0.0134)|Lung NSC(129;0.0207)|all_lung(136;0.0464)				ACTTGAGCTTCAAATTCCATC	0.313000													24	14					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28456214	28456214	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr15:28456214G>T	ENST00000261609.7	-	44	7111	c.7003C>A	c.(7003-7005)Cac>Aac	p.H2335N		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	2335					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		TTATCCTGGTGGGAGAGCAGC	0.502000													19	116					1.56452e-12	1.66883e-12	1	1	0
VARS2	57176	broad.mit.edu	37	6	30889068	30889068	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:30889068G>C	ENST00000321897.5	+	16	2250	c.1618G>C	c.(1618-1620)Gag>Cag	p.E540Q	VARS2_ENST00000542001.1_Missense_Mutation_p.E400Q|VARS2_ENST00000476162.1_3'UTR|VARS2_ENST00000541562.1_Missense_Mutation_p.E570Q|VARS2_ENST00000416670.2_Missense_Mutation_p.E540Q			Q5ST30	SYVM_HUMAN	valyl-tRNA synthetase 2, mitochondrial	540					valyl-tRNA aminoacylation	mitochondrion	ATP binding|valine-tRNA ligase activity			central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(15)|ovary(3)|prostate(3)|skin(4)|urinary_tract(1)	46						CCTGGTTGTAGAGGACCATGC	0.612000													25	61					0	0	1	0	0
AEN	64782	broad.mit.edu	37	15	89173447	89173447	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr15:89173447G>A	ENST00000332810.3	+	4	1051	c.900G>A	c.(898-900)atG>atA	p.M300I	AEN_ENST00000379231.3_Missense_Mutation_p.M300I	NM_022767.3	NP_073604.3	Q8WTP8	AEN_HUMAN	apoptosis enhancing nuclease	300					apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|response to ionizing radiation	nucleolus|nucleoplasm	exonuclease activity|nucleic acid binding			NS(1)|kidney(1)|large_intestine(1)|lung(4)	7						AACAGTACATGGAGGACCAGT	0.647000													5	8					0	0	1	0	0
PRKDC	5591	broad.mit.edu	37	8	48740729	48740729	+	Splice_Site	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:48740729C>T	ENST00000314191.2	-	63	8630	c.8574G>A	c.(8572-8574)caG>caA	p.Q2858Q	PRKDC_ENST00000338368.3_Splice_Site_p.Q2858Q|PRKDC_ENST00000523565.1_5'UTR	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	2859	KIP-binding.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				CAGACTTTACCTGAATACAAG	0.383000								Non-homologous end-joining					16	11					0	0	1	0	0
SPACA3	124912	broad.mit.edu	37	17	31324480	31324480	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:31324480C>T	ENST00000580599.1	+	5	722	c.313C>T	c.(313-315)Ctc>Ttc	p.L105F	SPACA3_ENST00000394637.2_3'UTR|SPACA3_ENST00000269053.3_Missense_Mutation_p.L174F|SPACA3_ENST00000394638.1_Missense_Mutation_p.L71F			Q8IXA5	SACA3_HUMAN	sperm acrosome associated 3	174					cell wall macromolecule catabolic process|defense response to Gram-positive bacterium|monocyte activation|peptidoglycan catabolic process|positive regulation of macrophage activation|positive regulation of phagocytosis|response to virus	acrosomal membrane|extracellular region|integral to membrane|lysosome	bacterial cell surface binding|lysozyme activity|protein binding			breast(1)|endometrium(1)|large_intestine(3)|lung(10)|ovary(2)|urinary_tract(1)	18			BRCA - Breast invasive adenocarcinoma(9;0.193)			GAATCCTAATCTCAAGGATAC	0.498000													55	101					0	0	1	0	0
VASH1	22846	broad.mit.edu	37	14	77242405	77242405	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr14:77242405G>A	ENST00000167106.4	+	5	1334	c.701G>A	c.(700-702)cGc>cAc	p.R234H	VASH1_ENST00000556038.1_3'UTR|RP11-488C13.6_ENST00000556368.1_RNA	NM_014909.4	NP_055724.1	Q7L8A9	VASH1_HUMAN	vasohibin 1	234					cell cycle arrest|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of endothelial cell proliferation	endoplasmic reticulum|extracellular space				breast(2)|endometrium(1)|large_intestine(1)|lung(1)|prostate(1)|stomach(1)|urinary_tract(3)	10			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0283)		CCCGCCTTCCGCACGCTCAGC	0.672000													7	19					0	0	1	0	0
SMURF1	57154	broad.mit.edu	37	7	98645380	98645380	+	Missense_Mutation	SNP	C	C	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:98645380C>A	ENST00000361125.1	-	11	1476	c.1157G>T	c.(1156-1158)aGa>aTa	p.R386I	AC004893.11_ENST00000468960.2_RNA|AC004893.11_ENST00000482799.2_RNA|SMURF1_ENST00000361368.2_Missense_Mutation_p.R360I	NM_020429.2	NP_065162.1	Q9HCE7	SMUF1_HUMAN	SMAD specific E3 ubiquitin protein ligase 1	386					BMP signaling pathway|cell differentiation|ectoderm development|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein export from nucleus|protein localization at cell surface|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|plasma membrane	activin binding|I-SMAD binding|R-SMAD binding|ubiquitin-protein ligase activity			endometrium(3)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|skin(2)|urinary_tract(1)	25	all_cancers(62;1.05e-08)|all_epithelial(64;4.34e-09)|Lung NSC(181;0.00902)|all_lung(186;0.0145)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)|Lung(104;0.224)			CAGTTCGTGTCTGAGGACTTT	0.562000													70	264					1.77791e-30	1.96184e-30	1	1	0
PCDH8	5100	broad.mit.edu	37	13	53420180	53420180	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr13:53420180C>T	ENST00000377942.3	-	1	2595	c.2392G>A	c.(2392-2394)Gga>Aga	p.G798R	PCDH8_ENST00000338862.4_Intron	NM_002590.3	NP_002581.2	O95206	PCDH8_HUMAN	protocadherin 8	798					cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(23)|ovary(1)|skin(1)|urinary_tract(1)	36		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		GCCGAGGCTccgccgcccgcc	0.756000													4	12					0	0	1	0	0
ZKSCAN1	7586	broad.mit.edu	37	7	99621898	99621898	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:99621898C>T	ENST00000324306.6	+	3	782	c.548C>T	c.(547-549)tCg>tTg	p.S183L	ZKSCAN1_ENST00000426572.1_Missense_Mutation_p.S147L|ZKSCAN1_ENST00000535170.1_Intron	NM_003439.1	NP_003430.1	P17029	ZKSC1_HUMAN	zinc finger with KRAB and SCAN domains 1	183					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(5)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			TTCAAACATTCGTCTCGGAAA	0.532000													17	57					0	0	1	0	0
POLK	51426	broad.mit.edu	37	5	74892196	74892196	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:74892196G>A	ENST00000241436.4	+	13	1850	c.1678G>A	c.(1678-1680)Gaa>Aaa	p.E560K	POLK_ENST00000506928.1_3'UTR|POLK_ENST00000380481.3_Missense_Mutation_p.E470K|POLK_ENST00000508526.1_Missense_Mutation_p.E362K|POLK_ENST00000352007.5_Missense_Mutation_p.E362K|POLK_ENST00000504026.1_Intron	NM_016218.2	NP_057302.1	Q9UBT6	POLK_HUMAN	polymerase (DNA directed) kappa	560					DNA replication|nucleotide-excision repair, DNA gap filling	nucleus	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			endometrium(1)|kidney(4)|large_intestine(5)|lung(11)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	27		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;2.9e-54)|all cancers(79;1.27e-42)		AAAACCTCTAGAAATGTCTCA	0.358000								DNA polymerases (catalytic subunits)					24	23					0	0	1	0	0
DUSP11	8446	broad.mit.edu	37	2	73993695	73993695	+	Nonsense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr2:73993695G>C	ENST00000272444.3	-	8	826	c.785C>G	c.(784-786)tCa>tGa	p.S262*	DUSP11_ENST00000480948.1_Intron	NM_003584.2	NP_003575.2	O75319	DUS11_HUMAN	dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)	215					RNA processing	nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity|RNA binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(4)|skin(1)	12						AAAATCACTTGACCTGGGTAC	0.378000													74	43					0	0	1	0	0
POLK	51426	broad.mit.edu	37	5	74877153	74877153	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:74877153G>A	ENST00000241436.4	+	7	986	c.814G>A	c.(814-816)Gaa>Aaa	p.E272K	POLK_ENST00000506928.1_3'UTR|POLK_ENST00000380481.3_Missense_Mutation_p.E182K|POLK_ENST00000508526.1_Missense_Mutation_p.E272K|POLK_ENST00000352007.5_Missense_Mutation_p.E272K|POLK_ENST00000515295.1_Missense_Mutation_p.E272K|POLK_ENST00000504026.1_Missense_Mutation_p.E272K	NM_016218.2	NP_057302.1	Q9UBT6	POLK_HUMAN	polymerase (DNA directed) kappa	272	UmuC.				DNA replication|nucleotide-excision repair, DNA gap filling	nucleus	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			endometrium(1)|kidney(4)|large_intestine(5)|lung(11)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	27		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;2.9e-54)|all cancers(79;1.27e-42)		AGTGAACTTTGAAGAACAAAA	0.408000								DNA polymerases (catalytic subunits)					24	38					0	0	1	0	0
KIAA0922	23240	broad.mit.edu	37	4	154544213	154544213	+	Silent	SNP	C	C	T	rs140734056	byFrequency	TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr4:154544213C>T	ENST00000409663.3	+	29	4072	c.4020C>T	c.(4018-4020)gaC>gaT	p.D1340D	KIAA0922_ENST00000440693.1_Silent_p.D1257D|KIAA0922_ENST00000409959.3_Silent_p.D1341D	NM_015196.3	NP_056011.3	A2VDJ0	T131L_HUMAN	KIAA0922	1340						integral to membrane				breast(2)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(16)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	63	all_hematologic(180;0.093)	Renal(120;0.118)				CCATGGTGGACGCCCAGCACT	0.682000													8	57					0	0	1	0	0
IP6K1	9807	broad.mit.edu	37	3	49770248	49770248	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr3:49770248C>T	ENST00000321599.4	-	4	893	c.592G>A	c.(592-594)Gag>Aag	p.E198K	IP6K1_ENST00000460540.1_Missense_Mutation_p.E33K|IP6K1_ENST00000468463.1_Missense_Mutation_p.E198K|IP6K1_ENST00000395238.1_Missense_Mutation_p.E33K	NM_001242829.1|NM_153273.3	NP_001229758.1|NP_695005.1	Q92551	IP6K1_HUMAN	inositol hexakisphosphate kinase 1	198					phosphatidylinositol phosphorylation	cytoplasm|nucleus	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol trisphosphate 3-kinase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(2)|skin(2)	15						TCCTTGGACTCGGAGCGCATG	0.567000													18	44					0	0	1	0	0
NDE1	54820	broad.mit.edu	37	16	15758666	15758666	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:15758666G>A	ENST00000396355.1	+	3	857	c.31G>A	c.(31-33)Gag>Aag	p.E11K	NDE1_ENST00000342673.5_Missense_Mutation_p.E11K|NDE1_ENST00000396354.1_Missense_Mutation_p.E11K|NDE1_ENST00000396353.2_Missense_Mutation_p.E11K	NM_001143979.1	NP_001137451.1	Q9NXR1	NDE1_HUMAN	nudE neurodevelopment protein 1	11	Self-association (By similarity).				cell differentiation|cell division|centrosome duplication|establishment of chromosome localization|establishment of mitotic spindle orientation|G2/M transition of mitotic cell cycle|mitotic prometaphase|nervous system development	cleavage furrow|condensed chromosome kinetochore|cytosol|microtubule|spindle pole centrosome	microtubule binding			endometrium(3)|kidney(3)|large_intestine(1)|lung(5)|ovary(1)	13						TTTCAGCTCCGAGGAGGAAGA	0.433000													46	98					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103468019	103468019	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:103468019C>G	ENST00000358392.2	-	23	2415	c.2098G>C	c.(2098-2100)Ggg>Cgg	p.G700R	COL11A1_ENST00000370096.3_Missense_Mutation_p.G688R|COL11A1_ENST00000353414.4_Missense_Mutation_p.G649R|COL11A1_ENST00000461720.1_5'UTR|COL11A1_ENST00000512756.1_Missense_Mutation_p.G572R	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	688	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CCTGGAGGCCCAGGCTCCCCT	0.423000													7	7					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37508817	37508817	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:37508817G>A	ENST00000374660.1	+	40	4465	c.4366G>A	c.(4366-4368)Gaa>Aaa	p.E1456K	ANKRD30A_ENST00000361713.1_Missense_Mutation_p.E1337K|ANKRD30A_ENST00000602533.1_Missense_Mutation_p.E1337K			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1393						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						AGAGAAAGCAGAAACAGAAGT	0.279000													2	12					0	0	1	0	0
INADL	10207	broad.mit.edu	37	1	62263087	62263087	+	Silent	SNP	A	A	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:62263087A>G	ENST00000371158.2	+	11	1503	c.1389A>G	c.(1387-1389)ccA>ccG	p.P463P	INADL_ENST00000316485.6_Silent_p.P463P	NM_176877.2	NP_795352	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	463					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						CACTTGAACCACCTTCAGACA	0.448000													122	58					0	0	1	0	0
FLOT1	10211	broad.mit.edu	37	6	30698322	30698322	+	Silent	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:30698322G>C	ENST00000376389.3	-	11	1192	c.972C>G	c.(970-972)gcC>gcG	p.A324A	FLOT1_ENST00000456573.2_Silent_p.A276A	NM_005803.2	NP_005794.1	O75955	FLOT1_HUMAN	flotillin 1	324						centriolar satellite|endosome|integral to membrane|melanosome|membrane fraction				breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(6)|prostate(1)	13						CTATGGCAAAGGCCTCAGCTT	0.567000													25	249					0	0	1	0	0
ADCY2	108	broad.mit.edu	37	5	7520895	7520895	+	Silent	SNP	G	G	A			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:7520895G>A	ENST00000338316.4	+	3	542	c.453G>A	c.(451-453)ctG>ctA	p.L151L		NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	151					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						ACACCATGCTGCCCTTCAACA	0.522000													32	150					0	0	1	0	0
MYOZ1	58529	broad.mit.edu	37	10	75391879	75391879	+	Missense_Mutation	SNP	G	G	T	rs149293567		TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:75391879G>T	ENST00000359322.4	-	6	1073	c.709C>A	c.(709-711)Cgc>Agc	p.R237S		NM_021245.3	NP_067068.1	Q9NP98	MYOZ1_HUMAN	myozenin 1	237					myofibril assembly	nucleus|pseudopodium	FATZ binding			central_nervous_system(1)|large_intestine(5)|lung(2)|ovary(2)|skin(2)	12	Prostate(51;0.0112)					AAGGTCATGCGTTTGGAGGCC	0.473000													11	60					0.000673444	0.000684134	1	1	0
ABCA9	10350	broad.mit.edu	37	17	66979930	66979930	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:66979930C>T	ENST00000340001.4	-	36	4771	c.4560G>A	c.(4558-4560)atG>atA	p.M1520I	ABCA9_ENST00000453985.2_Missense_Mutation_p.M1482I|ABCA9_ENST00000370732.2_3'UTR	NM_080283.3	NP_525022.2	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 9	1520	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(21)|lung(35)|ovary(4)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	91	Breast(10;1.47e-12)					TCTTCAGCTTCATCTCCAGCA	0.468000													21	78					0	0	1	0	0
OS9	10956	broad.mit.edu	37	12	58110272	58110272	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:58110272G>C	ENST00000315970.7	+	8	1011	c.970G>C	c.(970-972)Gga>Cga	p.G324R	OS9_ENST00000435406.2_Missense_Mutation_p.G272R|OS9_ENST00000439210.2_Missense_Mutation_p.G265R|OS9_ENST00000257966.8_Missense_Mutation_p.G325R|OS9_ENST00000552285.1_Missense_Mutation_p.G324R|RP11-571M6.7_ENST00000549477.1_RNA|OS9_ENST00000389142.5_Missense_Mutation_p.G324R|OS9_ENST00000551035.1_Missense_Mutation_p.G292R|OS9_ENST00000413095.2_Intron|OS9_ENST00000389146.6_Missense_Mutation_p.G324R	NM_001017958.2|NM_006812.3	NP_001017958.1|NP_006803.1	Q13438	OS9_HUMAN	osteosarcoma amplified 9, endoplasmic reticulum lectin	324					ER-associated protein catabolic process|protein retention in ER lumen|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to endoplasmic reticulum stress	endoplasmic reticulum lumen|Hrd1p ubiquitin ligase complex	glycoprotein binding|protein binding|sugar binding			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	21	all_neural(12;0.00548)|Glioma(12;0.0126)|Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			CCAGGCCCCAGGAGGGGAGGA	0.597000													2	6					0	0	1	0	0
ANLN	54443	broad.mit.edu	37	7	36438775	36438775	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:36438775C>T	ENST00000265748.2	+	3	481	c.260C>T	c.(259-261)cCa>cTa	p.P87L	ANLN_ENST00000396068.2_Missense_Mutation_p.P87L	NM_018685.2	NP_061155.2	Q9NQW6	ANLN_HUMAN	anillin, actin binding protein	87	Interaction with CD2AP.|Nuclear localization.				cytokinesis|mitosis|regulation of exit from mitosis|septin ring assembly	actomyosin contractile ring|nucleus	actin binding			breast(2)|endometrium(5)|kidney(5)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(2)	45						AATAAACAACCAGTTGAGTCG	0.418000													14	51					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77764196	77764196	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:77764196C>G	ENST00000521891.2	+	10	5487	c.5039C>G	c.(5038-5040)tCt>tGt	p.S1680C	ZFHX4_ENST00000455469.2_Missense_Mutation_p.S1635C|ZFHX4_ENST00000050961.6_Missense_Mutation_p.S1635C|ZFHX4_ENST00000518282.1_Missense_Mutation_p.S1654C	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	1635	Gln-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GATTTAATCTCTGCTCAACCT	0.418000										HNSCC(33;0.089)			54	31					0	0	1	0	0
LRRC37A11P	342666	broad.mit.edu	37	17	37187969	37187969	+	RNA	SNP	C	C	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:37187969C>T	ENST00000425901.2	+	0	1811					NR_033753.2																						TCCAGAGCTACGTAAGGAGGT	0.493000													8	69					0	0	1	0	0
SLC22A25	387601	broad.mit.edu	37	11	62951183	62951183	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:62951183C>G	ENST00000403374.2	-	6	742	c.439G>C	c.(439-441)Gac>Cac	p.D147H	SLC22A25_ENST00000306494.6_Missense_Mutation_p.D313H|SLC22A10_ENST00000535888.1_Intron|SLC22A10_ENST00000525620.1_Intron			Q6T423	S22AP_HUMAN	solute carrier family 22, member 25	313					transmembrane transport	integral to membrane				NS(2)|breast(2)|endometrium(4)|kidney(2)|large_intestine(7)|lung(7)|ovary(3)|skin(7)	34						GTTAGGATGTCTTCAGCATTC	0.438000													94	173					0	0	1	0	0
FOXE1	2304	broad.mit.edu	37	9	100617151	100617151	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr9:100617151G>C	ENST00000375123.3	+	1	1616	c.955G>C	c.(955-957)Gag>Cag	p.E319Q		NM_004473.3	NP_004464.2	O00358	FOXE1_HUMAN	forkhead box E1 (thyroid transcription factor 2)	319					cell migration|embryonic organ morphogenesis|hair follicle morphogenesis|hard palate development|lens morphogenesis in camera-type eye|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|peripheral nervous system development|pharynx development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|soft palate development|thymus development|thyroid gland development|thyroid hormone generation	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			central_nervous_system(1)|endometrium(1)|lung(2)|upper_aerodigestive_tract(1)	5		Acute lymphoblastic leukemia(62;0.158)				TGGCGGCGTGGAGACCACGGT	0.751000													8	3					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76445638	76445638	+	Missense_Mutation	SNP	A	A	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:76445638A>T	ENST00000389840.5	-	69	11151	c.11027T>A	c.(11026-11028)aTc>aAc	p.I3676N	DNAH17_ENST00000586052.1_5'UTR|DNAH17_ENST00000585328.1_Missense_Mutation_p.I3685N					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GGTCCTCTGGATGGCTTTCTC	0.617000													4	11					0	0	1	0	0
CRYAB	1410	broad.mit.edu	37	11	111780950	111780950	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:111780950G>T	ENST00000533971.1	-	2	516	c.425C>A	c.(424-426)cCa>cAa	p.P142Q	CRYAB_ENST00000525823.1_Intron|CRYAB_ENST00000526180.1_Intron|CRYAB_ENST00000527950.1_Intron|CRYAB_ENST00000533475.1_Intron|CRYAB_ENST00000227251.3_Intron|CRYAB_ENST00000531198.1_Intron|CRYAB_ENST00000533280.1_Intron			P02511	CRYAB_HUMAN	crystallin, alpha B	0					anti-apoptosis|muscle contraction|negative regulation of intracellular transport|protein folding|protein homooligomerization|response to heat	cytoplasm|nucleus	protein homodimerization activity|structural constituent of eye lens|unfolded protein binding			endometrium(1)|large_intestine(1)|lung(2)|skin(4)	8		all_cancers(61;1.26e-15)|all_epithelial(67;9.52e-10)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;3.57e-07)|BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|all cancers(92;6.57e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.051)		GTTATGGCTTGGGACTGGAAT	0.418000													6	22					0.248553	0.249854	1	1	0
IQGAP3	128239	broad.mit.edu	37	1	156530742	156530743	+	Frame_Shift_Ins	INS	-	-	C			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:156530742_156530743insC	ENST00000361170.2	-	11	1122_1123	c.1112_1113insG	c.(1111-1113)ggtfs	p.G371fs		NM_178229.4	NP_839943.2	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	371					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(14)|lung(29)|ovary(5)|prostate(5)|skin(5)|urinary_tract(3)	75	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GTTCCTGATCACCCTTTGTGTT	0.525													7	113	---	---	---	---					
FAM177A1P1	728710	broad.mit.edu	37	4	99877753	99877753	+	RNA	DEL	A	A	-	rs33952764		TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr4:99877753delA	ENST00000583654.1	+	0	237																											actctgtctcaaaaaaaaaaa	0.448													4	5	---	---	---	---					
ANXA6	309	broad.mit.edu	37	5	150515861	150515861	+	Frame_Shift_Del	DEL	C	C	-			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:150515861delC	ENST00000354546.5	-	7	672	c.445delG	c.(445-447)gacfs	p.D149fs	ANXA6_ENST00000523714.1_Frame_Shift_Del_p.D117fs|ANXA6_ENST00000377751.5_Intron|ANXA6_ENST00000521512.1_Intron|ANXA6_ENST00000356496.5_Frame_Shift_Del_p.D149fs	NM_001155.4	NP_001146.2	P08133	ANXA6_HUMAN	annexin A6	149						melanosome	calcium ion binding|calcium-dependent phospholipid binding|protein binding			endometrium(2)|kidney(1)|lung(9)	12		Medulloblastoma(196;0.0912)|all_hematologic(541;0.208)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCAGAGGTGTCGCCGATGATG	0.547													27	34	---	---	---	---					
CPXM2	119587	broad.mit.edu	37	10	125528165	125528167	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:125528165_125528167delCAG	ENST00000241305.3	-	9	1328_1330	c.1174_1176delCTG	c.(1174-1176)ctgdel	p.L392del	CPXM2_ENST00000368854.3_5'UTR	NM_198148.2	NP_937791.2	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	392	Poly-Leu.				cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(7)|kidney(2)|large_intestine(13)|lung(15)|ovary(2)|prostate(2)|skin(3)	47		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		CGAACTGCACCAGCAGCAGCAGC	0.626													7	154	---	---	---	---					
OVCH2	341277	broad.mit.edu	37	11	7720159	7720160	+	RNA	INS	-	-	T	rs71470493	by1000genomes	TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:7720159_7720160insT	ENST00000454689.1	-	0	925				OVCH2_ENST00000534193.2_RNA	NM_198185.3	NP_937828.3			ovochymase 2 (gene/pseudogene)											cervix(1)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(2)	15				Epithelial(150;7.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.197)		GGCATAATGGCTGTAGGTGCTC	0.475													2	4	---	---	---	---					
PCNXL3	399909	broad.mit.edu	37	11	65393419	65393421	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:65393419_65393421delCTT	ENST00000355703.3	+	20	3812_3814	c.3273_3275delCTT	c.(3271-3276)ggcttc>ggc	p.F1093del		NM_032223.2	NP_115599.2	Q9H6A9	PCX3_HUMAN	pecanex-like 3 (Drosophila)	1093						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)	13						GGGCCGTGGGCTTCTTCACACAT	0.606											OREG0021084	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	26	---	---	---	---					
RB1	5925	broad.mit.edu	37	13	49037882	49037897	+	Frame_Shift_Del	DEL	ATGTATGGCATATGCA	ATGTATGGCATATGCA	-	rs137853296		TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr13:49037882_49037897delATGTATGGCATATGCA	ENST00000267163.4	+	21	2260_2275	c.2122_2137delATGTATGGCATATGCA	c.(2122-2139)atgtatggcatatgcaaafs	p.MYGICK708fs		NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1	708	Domain B.|Pocket; binds T and E1A.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(10)|p.I703_E737del(2)|p.C712_A727del(1)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GATGTGTTCCATGTATGGCATATGCAAAGTGAAGAA	0.296		6	"""D, Mis, N, F, S"""		"""retinoblastoma, sarcoma, breast, small cell lung"""	"""retinoblastoma, sarcoma, breast, small cell lung"""			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			8	36	---	---	---	---					
OR4N4	283694	broad.mit.edu	37	15	22382920	22382921	+	Frame_Shift_Ins	INS	-	-	T			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr15:22382920_22382921insT	ENST00000328795.4	+	1	539_540	c.448_449insT	c.(448-450)cttfs	p.L150fs	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	150					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		GGCTCTGTGGCTTGGGGGTTTT	0.535													23	132	---	---	---	---					
SPRED3	399473	broad.mit.edu	37	19	38882864	38882866	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:38882864_38882866delCCT	ENST00000587013.1	+	3	569_571	c.491_493delCCT	c.(490-495)ccctcc>ccc	p.S172del	SPRED3_ENST00000586301.1_In_Frame_Del_p.S128del|SPRED3_ENST00000587564.2_3'UTR|SPRED3_ENST00000338502.4_In_Frame_Del_p.S128del			Q2MJR0	SPRE3_HUMAN	sprouty-related, EVH1 domain containing 3	128					multicellular organismal development					central_nervous_system(2)|large_intestine(1)|lung(5)|skin(1)	9	all_cancers(60;3.4e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			TCACTCAccccctcctcctcctc	0.645													7	46	---	---	---	---					
MMP9	4318	broad.mit.edu	37	20	44639945	44639945	+	Frame_Shift_Del	DEL	C	C	-			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr20:44639945delC	ENST00000372330.3	+	5	832	c.813delC	c.(811-813)tgcfs	p.C271fs		NM_004994.2	NP_004985.2	P14780	MMP9_HUMAN	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	271	Fibronectin type-II 1.				collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(4)|large_intestine(14)|liver(2)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(3)	46		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)	TTGGCTTCTGCCCCAGCGAGA	0.657													39	82	---	---	---	---