Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
OGDHL	55753	broad.mit.edu	37	10	50952768	50952768	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr10:50952768C>T	ENST00000374103.4	-	13	1745	c.1660G>A	c.(1660-1662)Gag>Aag	p.E554K	OGDHL_ENST00000432695.1_Missense_Mutation_p.E345K|OGDHL_ENST00000419399.1_Missense_Mutation_p.E497K	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	554					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						TAAGCCTCCTCACAGATCCGG	0.542000													21	40					0	0	1	0	0
RHBDL2	54933	broad.mit.edu	37	1	39384795	39384795	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:39384795C>T	ENST00000289248.2	-	2	1098	c.90G>A	c.(88-90)atG>atA	p.M30I	RP5-864K19.4_ENST00000433671.2_RNA|RHBDL2_ENST00000372985.3_Missense_Mutation_p.M110I|RHBDL2_ENST00000372990.1_Missense_Mutation_p.M30I|RHBDL2_ENST00000540558.1_Missense_Mutation_p.M30I|RHBDL2_ENST00000538156.1_Missense_Mutation_p.M97I			Q9NX52	RHBL2_HUMAN	rhomboid, veinlet-like 2 (Drosophila)	30					proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(3)	8	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;8.23e-17)			CATCCTCTCTCATTTTCTCCT	0.488000													27	91					0	0	1	0	0
NEU4	129807	broad.mit.edu	37	2	242757402	242757402	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:242757402C>T	ENST00000391969.2	+	5	1194	c.483C>T	c.(481-483)ccC>ccT	p.P161P	NEU4_ENST00000325935.6_Silent_p.P174P|NEU4_ENST00000405370.1_Silent_p.P161P|NEU4_ENST00000407683.1_Silent_p.P161P|NEU4_ENST00000404257.1_Silent_p.P173P	NM_001167602.1	NP_001161074.1	Q8WWR8	NEUR4_HUMAN	sialidase 4	161						lysosomal lumen|organelle inner membrane	exo-alpha-sialidase activity|protein binding			breast(1)|lung(10)|prostate(2)|skin(2)	15		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;3.84e-33)|all cancers(36;8.08e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.41e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0825)		CTGTGGGTCCCGGCCACGGCG	0.706000													9	6					0	0	1	0	0
DHRS7	51635	broad.mit.edu	37	14	60622822	60622822	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr14:60622822C>G	ENST00000216500.5	-	3	637	c.182G>C	c.(181-183)gGa>gCa	p.G61A	DHRS7_ENST00000557185.1_Missense_Mutation_p.G61A|PCNXL4_ENST00000406949.1_Intron|DHRS7_ENST00000536410.2_Missense_Mutation_p.G11A|PCNXL4_ENST00000553898.1_Intron			Q9Y394	DHRS7_HUMAN	dehydrogenase/reductase (SDR family) member 7	61							binding|oxidoreductase activity			endometrium(1)|lung(1)|ovary(1)|prostate(1)|urinary_tract(1)	5				OV - Ovarian serous cystadenocarcinoma(108;0.121)		CTCACCAATTCCACTCGAGGC	0.463000													29	47					0	0	1	0	0
ZNF518B	85460	broad.mit.edu	37	4	10446215	10446215	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr4:10446215G>A	ENST00000326756.3	-	3	2176	c.1738C>T	c.(1738-1740)Cac>Tac	p.H580Y		NM_053042.2	NP_444270.2	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	580					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(16)|ovary(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	42						ACTGCCTTGTGTTCCTCTGTC	0.393000													30	47					0	0	1	0	0
CDON	50937	broad.mit.edu	37	11	125889642	125889642	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr11:125889642G>A	ENST00000392693.3	-	4	495	c.368C>T	c.(367-369)tCa>tTa	p.S123L	CDON_ENST00000263577.7_Missense_Mutation_p.S123L	NM_001243597.1|NM_016952.4	NP_001230526.1|NP_058648.4	Q4KMG0	CDON_HUMAN	cell adhesion associated, oncogene regulated	123	Ig-like C2-type 2.				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(9)|ovary(3)|prostate(2)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	61	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		CTTTGTGGATGAACCAAAATC	0.353000													13	30					0	0	1	0	0
P2RX3	5024	broad.mit.edu	37	11	57135555	57135555	+	Silent	SNP	C	C	T	rs150261482		TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr11:57135555C>T	ENST00000263314.2	+	9	949	c.915C>T	c.(913-915)ttC>ttT	p.F305F		NM_002559.3	NP_002550.2	P56373	P2RX3_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 3	305					positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity			endometrium(4)|kidney(2)|large_intestine(4)|lung(15)|prostate(1)	26						GCATCCGCTTCGACGTGCTGG	0.567000													12	76					0	0	1	0	0
PLXNC1	10154	broad.mit.edu	37	12	94658921	94658921	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr12:94658921G>A	ENST00000258526.4	+	21	3766	c.3517G>A	c.(3517-3519)Gtg>Atg	p.V1173M	PLXNC1_ENST00000545312.1_5'UTR|PLXNC1_ENST00000547057.1_Missense_Mutation_p.V220M	NM_005761.2	NP_005752.1	O60486	PLXC1_HUMAN	plexin C1	1173					axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(12)|lung(30)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						CAAGGGTCCCGTGGATGTAAT	0.448000													109	139					0	0	1	0	0
ALDH4A1	8659	broad.mit.edu	37	1	19204070	19204070	+	Missense_Mutation	SNP	G	G	A	rs139430775		TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:19204070G>A	ENST00000375341.3	-	10	1234	c.977C>T	c.(976-978)tCg>tTg	p.S326L	ALDH4A1_ENST00000538839.1_Missense_Mutation_p.S326L|RP13-279N23.2_ENST00000494072.3_3'UTR|ALDH4A1_ENST00000538309.1_Missense_Mutation_p.S266L|ALDH4A1_ENST00000290597.5_Missense_Mutation_p.S326L	NM_003748.3	NP_003739.2	P30038	AL4A1_HUMAN	aldehyde dehydrogenase 4 family, member A1	326					proline biosynthetic process|proline catabolic process	mitochondrial matrix	1-pyrroline-5-carboxylate dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|electron carrier activity			cervix(2)|endometrium(1)|large_intestine(3)|lung(8)|prostate(1)	15		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00479)|BRCA - Breast invasive adenocarcinoma(304;3.67e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	NADH(DB00157)	CACGTCGGCCGAGCGGTGCAC	0.672000													3	19					0	0	1	0	0
GDF5OS	554250	broad.mit.edu	37	20	34022585	34022585	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr20:34022585G>C	ENST00000374375.1	+	2	1071	c.629G>C	c.(628-630)aGa>aCa	p.R210T	GDF5_ENST00000374369.3_Intron|GDF5_ENST00000374372.1_Intron																cervix(1)|endometrium(4)|lung(4)	9						CGGTCATCTAGAGAGAACACC	0.607000													67	117					0	0	1	0	0
SORCS1	114815	broad.mit.edu	37	10	108923757	108923757	+	Silent	SNP	G	G	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr10:108923757G>T	ENST00000263054.6	-	1	535	c.528C>A	c.(526-528)gcC>gcA	p.A176A	SORCS1_ENST00000344440.6_Silent_p.A176A	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	176						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		AGTGGACCATGGCTTGGTTGT	0.582000													19	36					2.89027e-11	3.11432e-11	1	1	0
TBC1D2B	23102	broad.mit.edu	37	15	78290635	78290635	+	Missense_Mutation	SNP	C	C	T	rs117285325	by1000genomes	TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr15:78290635C>T	ENST00000409931.3	-	13	2778	c.2707G>A	c.(2707-2709)Gac>Aac	p.D903N	TBC1D2B_ENST00000300584.3_Missense_Mutation_p.R920Q|TBC1D2B_ENST00000492078.1_5'UTR			Q9UPU7	TBD2B_HUMAN	TBC1 domain family, member 2B	0						intracellular	protein binding|Rab GTPase activator activity	p.D903N(3)|p.R920Q(1)		breast(3)|cervix(2)|endometrium(4)|kidney(1)|large_intestine(7)|lung(2)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	26						GTAGGCGCGTCGGTTCCGGAT	0.617000													4	15					0	0	1	0	0
ATP10A	57194	broad.mit.edu	37	15	25959383	25959383	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr15:25959383C>T	ENST00000356865.6	-	10	1893	c.1782G>A	c.(1780-1782)agG>agA	p.R594R		NM_024490.3	NP_077816.1	O60312	AT10A_HUMAN	ATPase, class V, type 10A	594					ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|breast(2)|endometrium(8)|kidney(2)|large_intestine(33)|liver(1)|lung(41)|ovary(3)|pancreas(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	103		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		CAAACCTCACCCTCACCTGCA	0.602000													19	26					0	0	1	0	0
ATF7IP	55729	broad.mit.edu	37	12	14649244	14649244	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr12:14649244C>T	ENST00000544627.1	+	14	3704	c.3384C>T	c.(3382-3384)ctC>ctT	p.L1128L	ATF7IP_ENST00000536444.1_Silent_p.L1119L|ATF7IP_ENST00000540793.1_Silent_p.L1120L|ATF7IP_ENST00000261168.4_Silent_p.L1120L			Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting protein	1120					DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			cervix(1)|endometrium(7)|kidney(5)|large_intestine(10)|liver(2)|lung(22)|ovary(1)|prostate(4)|skin(1)|urinary_tract(1)	54						GACCTCAGCTCACAGTGCATC	0.393000													20	38					0	0	1	0	0
THUMPD2	80745	broad.mit.edu	37	2	39964112	39964112	+	Silent	SNP	A	A	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:39964112A>T	ENST00000505747.1	-	10	1302	c.1275T>A	c.(1273-1275)ccT>ccA	p.P425P	THUMPD2_ENST00000260619.6_Silent_p.P395P	NM_025264.4	NP_079540.2	Q9BTF0	THUM2_HUMAN	THUMP domain containing 2	425							methyltransferase activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|skin(1)	17		all_hematologic(82;0.248)				TGGAATTGAAAGGGATGTTGC	0.418000													36	62					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70504238	70504238	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:70504238G>A	ENST00000310961.5	+	22	3050	c.2632G>A	c.(2632-2634)Gaa>Aaa	p.E878K	LRRC7_ENST00000415775.2_Missense_Mutation_p.E157K|LRRC7_ENST00000035383.5_Missense_Mutation_p.E873K			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	873						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						CCCATTGCCTGAAAGGAAAGA	0.458000													35	63					0	0	1	0	0
WDR96	80217	broad.mit.edu	37	10	105903255	105903255	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr10:105903255C>T	ENST00000357060.3	-	32	4202	c.4087G>A	c.(4087-4089)Gaa>Aaa	p.E1363K	WDR96_ENST00000428666.1_Missense_Mutation_p.E1335K	NM_025145.5	NP_079421.5	Q8NDM7	WDR96_HUMAN	WD repeat domain 96	1363										NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(14)|lung(21)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						TCCAAGCCTTCTGGCATGTTA	0.383000													22	53					0	0	1	0	0
SPINK5	11005	broad.mit.edu	37	5	147475436	147475436	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr5:147475436G>A	ENST00000359874.3	+	10	923	c.850G>A	c.(850-852)Gaa>Aaa	p.E284K	SPINK5_ENST00000256084.7_Missense_Mutation_p.E284K|SPINK5_ENST00000476608.1_3'UTR|SPINK5_ENST00000398454.1_Missense_Mutation_p.E284K	NM_001127698.1	NP_001121170.1	Q9NQ38	ISK5_HUMAN	serine peptidase inhibitor, Kazal type 5	284	Kazal-like 4.				anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(16)|ovary(4)|prostate(1)|skin(5)|stomach(8)|upper_aerodigestive_tract(2)	64			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGAAAAGCTGAAGAAAAAAC	0.373000													35	30					0	0	1	0	0
CDR1	1038	broad.mit.edu	37	X	139866322	139866322	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chrX:139866322C>T	ENST00000370532.2	-	1	401	c.210G>A	c.(208-210)tcG>tcA	p.S70S		NM_004065.2	NP_004056.2	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1, 34kDa	70	23 X 6 AA approximate repeats.							p.S70S(1)		breast(1)|endometrium(3)|large_intestine(3)|lung(11)|prostate(2)|skin(4)|urinary_tract(1)	25	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				CCATAGCTTCCGAAAAATCCA	0.458000													3	48					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62297946	62297946	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr11:62297946C>T	ENST00000378024.4	-	5	4217	c.3943G>A	c.(3943-3945)Gag>Aag	p.E1315K	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	1315					nervous system development	nucleus	protein binding	p.E1315Q(1)		NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				AAGTGCATCTCAGGCATCTTA	0.522000													8	186					0	0	1	0	0
OR14J1	442191	broad.mit.edu	37	6	29274779	29274779	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr6:29274779C>T	ENST00000377160.2	+	1	377	c.313C>T	c.(313-315)Ctg>Ttg	p.L105L		NM_030946.1	NP_112208.1	Q9UGF5	O14J1_HUMAN	olfactory receptor, family 14, subfamily J, member 1	105					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(3)|lung(8)|ovary(2)|upper_aerodigestive_tract(2)	17						CTTCATAGCTCTGGCCTCATC	0.453000													47	43					0	0	1	0	0
ZNF860	344787	broad.mit.edu	37	3	32031962	32031962	+	Missense_Mutation	SNP	A	A	G	rs1808125	by1000genomes	TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr3:32031962A>G	ENST00000360311.4	+	2	1940	c.1391A>G	c.(1390-1392)cAt>cGt	p.H464R		NM_001137674.2	NP_001131146.2	A6NHJ4	ZN860_HUMAN	zinc finger protein 860	464					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|lung(4)|ovary(1)	8						AAGACCTTCCATCACAATTCA	0.418000													5	120					0	0	1	0	0
HCFC1	3054	broad.mit.edu	37	X	153224926	153224926	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chrX:153224926G>A	ENST00000310441.7	-	9	2427	c.1461C>T	c.(1459-1461)ctC>ctT	p.L487L	HCFC1_ENST00000369984.4_Silent_p.L487L|HCFC1_ENST00000354233.3_Silent_p.L418L	NM_005334.2	NP_005325.2	P51610	HCFC1_HUMAN	host cell factor C1 (VP16-accessory protein)	487					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(3)|large_intestine(3)|lung(18)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CGGTCACTTTGAGAACAGCAG	0.612000													16	26					0	0	1	0	0
CNOT6L	246175	broad.mit.edu	37	4	78650194	78650194	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr4:78650194C>G	ENST00000504123.1	-	10	1196	c.1066G>C	c.(1066-1068)Gtg>Ctg	p.V356L	CNOT6L_ENST00000264903.4_Missense_Mutation_p.V356L			Q96LI5	CNO6L_HUMAN	CCR4-NOT transcription complex, subunit 6-like	356					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	exonuclease activity|protein binding			kidney(1)|large_intestine(1)|lung(6)|urinary_tract(1)	9						GCATTTGCCACTATAAGCAGC	0.388000													22	60					0	0	1	0	0
ATAD5	79915	broad.mit.edu	37	17	29162311	29162311	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:29162311G>A	ENST00000321990.4	+	2	1590	c.1212G>A	c.(1210-1212)atG>atA	p.M404I	CTD-2349P21.11_ENST00000580873.1_RNA	NM_024857.3	NP_079133.3	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	404					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(18)|lung(13)|ovary(3)|pancreas(1)	51		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				AGCAATTTATGAAAGCATTTA	0.358000													12	44					0	0	1	0	0
C19orf73	55150	broad.mit.edu	37	19	49622031	49622031	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:49622031G>A	ENST00000408991.2	-	1	366	c.249C>T	c.(247-249)tcC>tcT	p.S83S		NM_018111.2	NP_060581.2	Q9NVV2	CS073_HUMAN	chromosome 19 open reading frame 73	83										large_intestine(1)|lung(2)	3						AAACGCAGCCGGAGCCAGTGG	0.657000													3	83					0	0	1	0	0
HPS4	89781	broad.mit.edu	37	22	26860275	26860275	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr22:26860275C>G	ENST00000398145.2	-	11	1937	c.1321G>C	c.(1321-1323)Gag>Cag	p.E441Q	HPS4_ENST00000336873.5_Missense_Mutation_p.E441Q|HPS4_ENST00000402105.3_Missense_Mutation_p.E436Q|HPS4_ENST00000398141.1_Missense_Mutation_p.E454Q	NM_022081.5	NP_071364.4	Q9NQG7	HPS4_HUMAN	Hermansky-Pudlak syndrome 4	441					lysosome organization|positive regulation of eye pigmentation|protein stabilization|protein targeting	lysosome|melanosome|membrane fraction|platelet dense granule	protein homodimerization activity			breast(2)|endometrium(3)|kidney(5)|large_intestine(4)|lung(12)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	32						TCGAGCTGCTCTTGGGCTCCA	0.632000									Hermansky-Pudlak syndrome				27	79					0	0	1	0	0
NUPL2	11097	broad.mit.edu	37	7	23239972	23239972	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr7:23239972G>A	ENST00000258742.5	+	7	1139	c.880G>A	c.(880-882)Gaa>Aaa	p.E294K		NM_007342.2	NP_031368.1	O15504	NUPL2_HUMAN	nucleoporin like 2	294	Ser-rich.				carbohydrate metabolic process|glucose transport|mRNA transport|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nuclear pore	nuclear export signal receptor activity|nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(4)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						TGGGAAGCCTGAAGTCACATC	0.502000													9	10					0	0	1	0	0
NF1	4763	broad.mit.edu	37	17	29533336	29533336	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:29533336C>T	ENST00000358273.4	+	12	1722	c.1339C>T	c.(1339-1341)Ctt>Ttt	p.L447F	NF1_ENST00000431387.4_Missense_Mutation_p.L447F|NF1_ENST00000356175.3_Missense_Mutation_p.L447F	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	447					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(6)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TGGTGAAACACTTCATAAAGC	0.413000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			40	90					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101442180	101442180	+	Splice_Site	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr12:101442180G>A	ENST00000392979.3	+	13	1568		c.e13+1		ANO4_ENST00000550015.1_Splice_Site|ANO4_ENST00000392977.3_Splice_Site|ANO4_ENST00000299222.9_Splice_Site	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4							chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						GCAGTCTGGGGTAAGTGTTCT	0.373000										HNSCC(74;0.22)			13	39					0	0	1	0	0
TLE1	7088	broad.mit.edu	37	9	84235445	84235445	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr9:84235445G>A	ENST00000376499.3	-	9	1686	c.622C>T	c.(622-624)Cta>Tta	p.L208L	TLE1_ENST00000464999.1_5'UTR|TLE1_ENST00000376472.1_5'UTR	NM_005077.3	NP_005068.2	Q04724	TLE1_HUMAN	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	208	CCN domain.				negative regulation of Wnt receptor signaling pathway|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway		transcription factor binding			NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	29						GTGCCTCTTAGACTGTCTGGG	0.408000													16	50					0	0	1	0	0
IGHV3-73	28409	broad.mit.edu	37	14	107211238	107211238	+	RNA	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr14:107211238G>C	ENST00000390636.2	-	0	130																											CCTCACACTGGACACCTGCAA	0.572000													88	79					0	0	1	0	0
KIF1A	547	broad.mit.edu	37	2	241710491	241710491	+	Nonsense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:241710491G>C	ENST00000498729.2	-	15	1484	c.1238C>G	c.(1237-1239)tCa>tGa	p.S413*	KIF1A_ENST00000320389.7_Nonsense_Mutation_p.S404*	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	404					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		GAGCGAGGATGAGGGGCTCAT	0.617000													13	40					0	0	1	0	0
RBM27	54439	broad.mit.edu	37	5	145609388	145609388	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr5:145609388G>C	ENST00000265271.5	+	5	670	c.504G>C	c.(502-504)aaG>aaC	p.K168N	RBM27_ENST00000506502.1_Missense_Mutation_p.K168N	NM_018989.1	NP_061862.1	Q9P2N5	RBM27_HUMAN	RNA binding motif protein 27	168	Arg-rich.				mRNA processing	cytoplasm|nuclear speck	nucleotide binding|RNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(3)|endometrium(4)|kidney(5)|large_intestine(7)|liver(2)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	39			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCAggagtaagagtcggagta	0.493000													38	57					0	0	1	0	0
ACRC	93953	broad.mit.edu	37	X	70823836	70823836	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chrX:70823836G>A	ENST00000373695.1	+	7	1246	c.709G>A	c.(709-711)Gac>Aac	p.D237N	ACRC_ENST00000373696.3_Missense_Mutation_p.D237N			Q96QF7	ACRC_HUMAN	acidic repeat containing	237	Asp/Ser-rich.					nucleus				autonomic_ganglia(1)|breast(1)|endometrium(15)|kidney(4)|large_intestine(4)|lung(20)|ovary(5)|prostate(1)|skin(2)|stomach(1)	54	Renal(35;0.156)					TGTTCCCGACGACAGCAGTGA	0.537000													248	47					0	0	1	0	0
M1AP	130951	broad.mit.edu	37	2	74842183	74842183	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:74842183G>A	ENST00000290536.5	-	3	450	c.334C>T	c.(334-336)Ctg>Ttg	p.L112L	M1AP_ENST00000358434.2_5'UTR|M1AP_ENST00000536235.1_Silent_p.L112L|M1AP_ENST00000409585.1_Silent_p.L112L	NM_001281296.1|NM_138804.3	NP_001268225.1|NP_620159.2			meiosis 1 associated protein																		GCCAGCCGCAGAGAAGCACCT	0.507000													32	87					0	0	1	0	0
RGS14	10636	broad.mit.edu	37	5	176794807	176794807	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr5:176794807C>T	ENST00000408923.3	+	7	908	c.720C>T	c.(718-720)ctC>ctT	p.L240L		NM_006480.4	NP_006471.2	O43566	RGS14_HUMAN	regulator of G-protein signaling 14	240					chromosome segregation|long-term memory|long-term synaptic potentiation|negative regulation of ERK1 and ERK2 cascade|negative regulation of MAP kinase activity|negative regulation of synaptic plasticity|nucleocytoplasmic transport|platelet-derived growth factor receptor signaling pathway|positive regulation of neurogenesis|regulation of DNA-dependent transcription in response to stress|regulation of G-protein coupled receptor protein signaling pathway|response to oxidative stress|spindle organization|visual learning|zygote asymmetric cell division	cell junction|centrosome|dendritic spine|microtubule|PML body|postsynaptic density|postsynaptic membrane|spindle pole	GDP-dissociation inhibitor activity|GTPase activator activity|microtubule binding|receptor signaling complex scaffold activity|receptor signaling protein activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(3)|skin(3)|upper_aerodigestive_tract(1)	12	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCCGCCCTCTCCGCAAGTCCT	0.652000													11	8					0	0	1	0	0
TRAK2	66008	broad.mit.edu	37	2	202264201	202264201	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:202264201C>T	ENST00000332624.3	-	5	807	c.379G>A	c.(379-381)Gaa>Aaa	p.E127K	TRAK2_ENST00000430254.1_Missense_Mutation_p.E127K	NM_015049.2	NP_055864.2	O60296	TRAK2_HUMAN	trafficking protein, kinesin binding 2	127						early endosome|plasma membrane	GABA receptor binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(12)|ovary(1)|skin(1)	23						GCAGCGAGTTCCAGATCACGA	0.413000													12	51					0	0	1	0	0
SNCAIP	9627	broad.mit.edu	37	5	121767723	121767723	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr5:121767723G>A	ENST00000261367.7	+	8	2811	c.1383G>A	c.(1381-1383)ctG>ctA	p.L461L	SNCAIP_ENST00000379533.2_Silent_p.L461L|SNCAIP_ENST00000503116.2_Silent_p.L461L|SNCAIP_ENST00000414317.2_Intron|SNCAIP_ENST00000379536.2_Silent_p.L354L|SNCAIP_ENST00000261368.8_Silent_p.L414L|SNCAIP_ENST00000504884.2_3'UTR|SNCAIP_ENST00000542191.1_5'UTR|SNCAIP_ENST00000379538.3_Silent_p.L48L			Q9Y6H5	SNCAP_HUMAN	synuclein, alpha interacting protein	414					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			NS(3)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	39		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		TTGCAGAACTGAGTTGTTCTA	0.403000													30	17					0	0	1	0	0
FOLH1B	219595	broad.mit.edu	37	11	89405073	89405073	+	RNA	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr11:89405073G>A	ENST00000532352.1	+	0	1013							Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B						proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(26)|ovary(4)|skin(4)|urinary_tract(2)	48						GTCATTCTGGGAGGTCACCGG	0.408000													17	60					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37027156	37027156	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chrX:37027156C>G	ENST00000358047.3	+	1	725	c.673C>G	c.(673-675)Cag>Gag	p.Q225E		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	225										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						TCTCCGCCCACAGCCTCCCAA	0.647000													4	72					0	0	1	0	0
GGH	8836	broad.mit.edu	37	8	63939794	63939794	+	Silent	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr8:63939794G>C	ENST00000260118.6	-	4	708	c.306C>G	c.(304-306)ctC>ctG	p.L102L	GGH_ENST00000518113.1_5'UTR	NM_003878.2	NP_003869.1	Q92820	GGH_HUMAN	gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)	102	Gamma-glutamyl hydrolase.				glutamine metabolic process	extracellular space|lysosome|melanosome	gamma-glutamyl-peptidase activity			breast(1)|kidney(1)|large_intestine(1)|liver(1)|lung(6)|stomach(1)	11	Breast(64;0.0716)	all_cancers(86;0.189)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.131)			Folic Acid(DB00158)|L-Glutamic Acid(DB00142)	CTGAGCGTCTGAGGTCAACAC	0.383000													35	111					0	0	1	0	0
CBLB	868	broad.mit.edu	37	3	105377858	105377858	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr3:105377858C>T	ENST00000264122.4	-	19	3226	c.2905G>A	c.(2905-2907)Gaa>Aaa	p.E969K	CBLB_ENST00000394027.3_Missense_Mutation_p.E947K|CBLB_ENST00000407712.1_Missense_Mutation_p.E184K	NM_170662.3	NP_733762.2	Q13191	CBLB_HUMAN	Cbl proto-oncogene B, E3 ubiquitin protein ligase	969	UBA.				cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(2)|urinary_tract(2)	49						AAGGCAAATTCTCGGAGGATG	0.468000			Mis S		AML								30	45					0	0	1	0	0
SYT4	6860	broad.mit.edu	37	18	40854029	40854029	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr18:40854029G>T	ENST00000255224.3	-	2	733	c.365C>A	c.(364-366)aCc>aAc	p.T122N	SYT4_ENST00000590752.1_Missense_Mutation_p.T104N|SYT4_ENST00000586678.1_Intron	NM_020783.3	NP_065834.1	Q9H2B2	SYT4_HUMAN	synaptotagmin IV	122						cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	44						GAGCTTCGGGGTTGCATTCTC	0.433000													22	49					9.78306e-22	1.08788e-21	1	1	0
SDHAP3	728609	broad.mit.edu	37	5	1589406	1589406	+	RNA	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr5:1589406C>T	ENST00000436493.2	-	0	472																											ATGCTTCCATCAGCAAATCTC	0.453000													11	31					0	0	1	0	0
MYBPC1	4604	broad.mit.edu	37	12	102069129	102069129	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr12:102069129C>G	ENST00000549145.1	+	26	2987	c.2887C>G	c.(2887-2889)Ctc>Gtc	p.L963V	MYBPC1_ENST00000547509.1_Missense_Mutation_p.L918V|MYBPC1_ENST00000545503.2_Missense_Mutation_p.L932V|MYBPC1_ENST00000553190.1_Missense_Mutation_p.L932V|MYBPC1_ENST00000551300.1_Missense_Mutation_p.L833V|MYBPC1_ENST00000550501.1_Intron|MYBPC1_ENST00000361466.2_Missense_Mutation_p.L957V|MYBPC1_ENST00000452455.2_Missense_Mutation_p.L950V|MYBPC1_ENST00000550270.1_Missense_Mutation_p.L950V|MYBPC1_ENST00000441232.1_Missense_Mutation_p.L950V|MYBPC1_ENST00000536007.1_Missense_Mutation_p.L913V|MYBPC1_ENST00000360610.2_Missense_Mutation_p.L950V|MYBPC1_ENST00000547405.1_Missense_Mutation_p.L906V|MYBPC1_ENST00000541119.1_Missense_Mutation_p.L920V|MYBPC1_ENST00000361685.2_Missense_Mutation_p.L957V|MYBPC1_ENST00000392934.3_Missense_Mutation_p.L919V			Q00872	MYPC1_HUMAN	myosin binding protein C, slow type	950	Fibronectin type-III 3.				cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	57						AAATGTCGCTCTCACATGGAC	0.478000													17	39					0	0	1	0	0
ST6GALNAC4	27090	broad.mit.edu	37	9	130670821	130670821	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr9:130670821C>G	ENST00000335791.5	-	6	1034	c.759G>C	c.(757-759)gaG>gaC	p.E253D	ST6GALNAC4_ENST00000343609.2_Missense_Mutation_p.E169D|ST6GALNAC4_ENST00000495983.1_5'UTR	NM_175039.3	NP_778204.1	Q9H4F1	SIA7D_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4	253					glycolipid metabolic process|protein glycosylation	integral to Golgi membrane|nucleus|soluble fraction	(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity			endometrium(1)|large_intestine(2)|lung(2)|prostate(2)	7						GCCGGCCCTTCTCAAAGTAGT	0.647000													44	48					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	114185981	114185981	+	Missense_Mutation	SNP	A	A	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr8:114185981A>T	ENST00000297405.5	-	4	923	c.679T>A	c.(679-681)Tcg>Acg	p.S227T	CSMD3_ENST00000519485.1_5'UTR|CSMD3_ENST00000352409.3_Missense_Mutation_p.S227T|CSMD3_ENST00000455883.2_Missense_Mutation_p.S227T|CSMD3_ENST00000343508.3_Missense_Mutation_p.S187T	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	227	Sushi 1.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						AAATCCCACGAAGCTGTATTA	0.428000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			41	139					0	0	1	0	0
RPRD2	23248	broad.mit.edu	37	1	150444774	150444774	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:150444774G>A	ENST00000401000.4	+	10	3337	c.3272G>A	c.(3271-3273)aGa>aAa	p.R1091K	RPRD2_ENST00000492220.1_3'UTR|RPRD2_ENST00000369068.4_Missense_Mutation_p.R1117K			Q5VT52	RPRD2_HUMAN	regulation of nuclear pre-mRNA domain containing 2	1117							protein binding			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						AAGGGAAATAGAGGACATGGG	0.522000													6	19					0	0	1	0	0
PIGS	94005	broad.mit.edu	37	17	26890869	26890869	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:26890869C>T	ENST00000308360.7	-	4	718	c.343G>A	c.(343-345)Gag>Aag	p.E115K	PIGS_ENST00000543734.1_Missense_Mutation_p.E54K|PIGS_ENST00000395346.2_Missense_Mutation_p.E107K	NM_033198.3	NP_149975.1	Q96S52	PIGS_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class S	115					attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	Lung NSC(42;0.00431)					GCCTCCTCCTCATGGTCCAAA	0.478000													43	130					0	0	1	0	0
FRG1B	284802	broad.mit.edu	37	20	29628283	29628283	+	Silent	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr20:29628283G>C	ENST00000278882.3	+	6	665	c.285G>C	c.(283-285)ggG>ggC	p.G95G	FRG1B_ENST00000358464.4_Silent_p.G95G|FRG1B_ENST00000439954.2_Silent_p.G100G														p.G95G(4)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGAAGCAGGGGACATAGAAG	0.378000													9	119					0	0	1	0	0
CHD6	84181	broad.mit.edu	37	20	40050336	40050336	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr20:40050336G>C	ENST00000373233.3	-	31	5116	c.4939C>G	c.(4939-4941)Caa>Gaa	p.Q1647E		NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1647					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				CTACTCATTTGAGAATATGTA	0.423000													12	26					0	0	1	0	0
PCDHGA10	56106	broad.mit.edu	37	5	140793016	140793016	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr5:140793016G>T	ENST00000398610.2	+	1	274	c.274G>T	c.(274-276)Ggc>Tgc	p.G92C	PCDHGB6_ENST00000520790.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGB3_ENST00000576222.1_Intron	NM_018913.2|NM_032090.1	NP_061736.1|NP_114479.1														breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	43			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GATCACCGCGGGCAGGATAGA	0.602000													62	58					3.19467e-53	3.59562e-53	1	1	0
POLD3	10714	broad.mit.edu	37	11	74340342	74340342	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr11:74340342C>G	ENST00000263681.2	+	9	1109	c.980C>G	c.(979-981)cCt>cGt	p.P327R	POLD3_ENST00000532497.1_Missense_Mutation_p.P221R|POLD3_ENST00000527458.1_Missense_Mutation_p.P288R	NM_006591.2	NP_006582.1	Q15054	DPOD3_HUMAN	polymerase (DNA-directed), delta 3, accessory subunit	327					base-excision repair|DNA strand elongation involved in DNA replication|DNA synthesis involved in DNA repair|mismatch repair|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm	DNA-directed DNA polymerase activity|protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|stomach(1)	18	Breast(11;3.21e-06)					ATCAAACTTCCTGAATCTGAT	0.388000													4	72					0	0	1	0	0
KIF1C	10749	broad.mit.edu	37	17	4905368	4905368	+	Silent	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:4905368C>G	ENST00000320785.5	+	6	735	c.378C>G	c.(376-378)ctC>ctG	p.L126L		NM_006612.5	NP_006603.2	O43896	KIF1C_HUMAN	kinesin family member 1C	126	Kinesin-motor.				microtubule-based movement|retrograde vesicle-mediated transport, Golgi to ER	endoplasmic reticulum|Golgi apparatus|microtubule	ATP binding|microtubule motor activity			NS(2)|breast(4)|endometrium(4)|kidney(2)|large_intestine(8)|lung(6)|skin(1)|urinary_tract(3)	30						GTGAGGACCTCTTCTCTCGCG	0.587000													34	48					0	0	1	0	0
C1orf116	79098	broad.mit.edu	37	1	207196604	207196604	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:207196604C>T	ENST00000359470.5	-	4	754	c.505G>A	c.(505-507)Gag>Aag	p.E169K	C1orf116_ENST00000461135.2_5'UTR	NM_023938.5	NP_076427.2	Q9BW04	SARG_HUMAN	chromosome 1 open reading frame 116	169						cytoplasm|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(4)|stomach(1)	29	Prostate(682;0.19)					TGTTCTTTCTCAGGCTCTGGC	0.602000													25	33					0	0	1	0	0
TULP4	56995	broad.mit.edu	37	6	158922867	158922867	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr6:158922867G>A	ENST00000367097.3	+	13	3529	c.2172G>A	c.(2170-2172)ctG>ctA	p.L724L	TULP4_ENST00000367094.2_Intron	NM_020245.4	NP_064630.2	Q9NRJ4	TULP4_HUMAN	tubby like protein 4	724					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			endometrium(7)|kidney(2)|large_intestine(15)|lung(17)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		TAGATGTCCTGACCAACCAGA	0.567000													83	34					0	0	1	0	0
ACSM5	54988	broad.mit.edu	37	16	20441100	20441100	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr16:20441100G>A	ENST00000331849.4	+	8	1249	c.1102G>A	c.(1102-1104)Gaa>Aaa	p.E368K		NM_017888.2	NP_060358.2	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	368					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(6)|lung(28)|ovary(3)|prostate(1)|skin(3)|urinary_tract(1)	51						GGAGCTGTACGAAGGCTATGG	0.617000													11	51					0	0	1	0	0
SERTAD1	29950	broad.mit.edu	37	19	40928872	40928872	+	Silent	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:40928872G>C	ENST00000357949.4	-	2	740	c.582C>G	c.(580-582)ctC>ctG	p.L194L		NM_013376.3	NP_037508.2	Q9UHV2	SRTD1_HUMAN	SERTA domain containing 1	194					positive regulation of cell proliferation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent					endometrium(2)|lung(1)|prostate(1)|skin(1)	5			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GGCCTGGTTTGAGGCCCTCAG	0.582000													4	6					0	0	1	0	0
GSKIP	51527	broad.mit.edu	37	14	96852000	96852000	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr14:96852000G>C	ENST00000556095.1	+	4	2211	c.399G>C	c.(397-399)ttG>ttC	p.L133F	GSKIP_ENST00000438650.1_Missense_Mutation_p.L133F|GSKIP_ENST00000555181.1_Missense_Mutation_p.L133F|GSKIP_ENST00000554182.1_Missense_Mutation_p.L133F	NM_001271904.1	NP_001258833.1			GSK3B interacting protein																		TGGAAGCTTTGAAAAGAGATG	0.438000													66	62					0	0	1	0	0
SP100	6672	broad.mit.edu	37	2	231308897	231308897	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:231308897C>T	ENST00000264052.5	+	4	630	c.275C>T	c.(274-276)tCt>tTt	p.S92F	SP100_ENST00000409112.1_Missense_Mutation_p.S92F|SP100_ENST00000409341.1_Missense_Mutation_p.S92F|SP100_ENST00000341950.4_Missense_Mutation_p.S92F|SP100_ENST00000409824.1_Missense_Mutation_p.S67F|SP100_ENST00000340126.4_Missense_Mutation_p.S92F|SP100_ENST00000409897.1_Missense_Mutation_p.S57F|SP100_ENST00000427101.2_Missense_Mutation_p.S67F	NM_003113.3	NP_003104.2	P23497	SP100_HUMAN	SP100 nuclear antigen	92	HSR.				DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|interspecies interaction between organisms|negative regulation of cellular component movement|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to cytokine stimulus|response to retinoic acid|response to type I interferon	cytoplasm|nuclear periphery|nucleolus|PML body	chromo shadow domain binding|DNA binding|identical protein binding|kinase binding|protein homodimerization activity|transcription coactivator activity|transcription corepressor activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(4)|upper_aerodigestive_tract(1)	25		Renal(207;0.0112)|all_lung(227;0.0335)|all_hematologic(139;0.0749)|Lung NSC(271;0.142)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		TTTAAGGATTCTCAAGATTCT	0.363000													14	24					0	0	1	0	0
CD207	50489	broad.mit.edu	37	2	71060100	71060100	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:71060100C>T	ENST00000410009.3	-	4	693	c.648G>A	c.(646-648)tgG>tgA	p.W216*		NM_015717.3	NP_056532	Q9UJ71	CLC4K_HUMAN	CD207 molecule, langerin	216	C-type lectin.				defense response to virus	endocytic vesicle|integral to membrane	mannose binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(13)|ovary(1)|stomach(1)	20						CGGCACTATACCAGGTCTTTG	0.478000													15	36					0	0	1	0	0
MFSD1	64747	broad.mit.edu	37	3	158538031	158538031	+	Missense_Mutation	SNP	A	A	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr3:158538031A>C	ENST00000415822.2	+	9	1067	c.926A>C	c.(925-927)aAg>aCg	p.K309T	MFSD1_ENST00000392813.4_Missense_Mutation_p.K270T|MFSD1_ENST00000264266.8_Missense_Mutation_p.K260T	NM_022736.2	NP_073573.2	Q9H3U5	MFSD1_HUMAN	major facilitator superfamily domain containing 1	260					transmembrane transport	integral to membrane		p.K260R(1)|p.K309R(1)		breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(15)|skin(1)	26			Lung(72;0.00372)|LUSC - Lung squamous cell carcinoma(72;0.00523)			ACTGATGTAAAGGACTTCTCC	0.363000													40	75					0	0	1	0	0
ANKRD11	29123	broad.mit.edu	37	16	89351818	89351818	+	Missense_Mutation	SNP	T	T	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr16:89351818T>C	ENST00000301030.4	-	9	1592	c.1132A>G	c.(1132-1134)Aat>Gat	p.N378D	ANKRD11_ENST00000378330.2_Missense_Mutation_p.N378D	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	378						nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		ATAAAACTATTGGATTTCGTT	0.433000													27	55					0	0	1	0	0
DEK	7913	broad.mit.edu	37	6	18264194	18264194	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr6:18264194C>T	ENST00000397239.3	-	2	472	c.25G>A	c.(25-27)Gag>Aag	p.E9K	DEK_ENST00000244776.7_Missense_Mutation_p.E9K	NM_003472.3	NP_003463.1	P35659	DEK_HUMAN	DEK oncogene	9					chromatin modification|regulation of transcription from RNA polymerase II promoter|signal transduction|transcription from RNA polymerase II promoter|viral genome replication	nucleus	DNA binding|histone binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	7	Ovarian(93;0.00769)|Breast(50;0.0495)	all_hematologic(90;0.053)	OV - Ovarian serous cystadenocarcinoma(7;0.00291)|all cancers(50;0.031)|Epithelial(50;0.0332)			CCCTCCCCCTCCGCAGCAGGG	0.682000			T	NUP214	AML								18	29					0	0	1	0	0
UMOD	7369	broad.mit.edu	37	16	20344666	20344666	+	Silent	SNP	G	G	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr16:20344666G>T	ENST00000396134.2	-	12	2115	c.1992C>A	c.(1990-1992)ctC>ctA	p.L664L	UMOD_ENST00000302509.4_Silent_p.L631L|UMOD_ENST00000570689.1_Silent_p.L631L|UMOD_ENST00000424589.1_Silent_p.L664L|UMOD_ENST00000396138.4_Silent_p.L680L|UMOD_ENST00000396142.2_Silent_p.L631L|UMOD_ENST00000570331.1_5'UTR	NM_001278614.1	NP_001265543.1	P07911	UROM_HUMAN	uromodulin	631					cellular defense response|negative regulation of cell proliferation	anchored to membrane|apical plasma membrane|basolateral plasma membrane|cilium membrane|extrinsic to membrane|primary cilium|spindle pole	calcium ion binding			endometrium(5)|kidney(1)|large_intestine(7)|lung(20)|ovary(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	41						AGGTGGCCGAGAGAAGCAGAG	0.542000													6	30					0.000274275	0.000282402	1	1	0
EPB41L3	23136	broad.mit.edu	37	18	5394743	5394743	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr18:5394743G>A	ENST00000341928.2	-	22	3543	c.3203C>T	c.(3202-3204)tCa>tTa	p.S1068L	EPB41L3_ENST00000540638.2_Missense_Mutation_p.S846L|EPB41L3_ENST00000544123.1_Intron|EPB41L3_ENST00000542146.1_Missense_Mutation_p.S373L|EPB41L3_ENST00000542652.2_5'UTR|EPB41L3_ENST00000400111.3_Missense_Mutation_p.S846L|EPB41L3_ENST00000427684.2_Missense_Mutation_p.S365L|EPB41L3_ENST00000342933.3_Missense_Mutation_p.S1068L	NM_012307.2	NP_036439.2	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	1068	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(52)|ovary(5)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	105						TTTGGTCACTGACATGTCAGG	0.502000													24	74					0	0	1	0	0
PRKD3	23683	broad.mit.edu	37	2	37481367	37481367	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:37481367G>A	ENST00000379066.1	-	18	3241	c.2479C>T	c.(2479-2481)Ctt>Ttt	p.L827F	PRKD3_ENST00000234179.2_Missense_Mutation_p.L827F			O94806	KPCD3_HUMAN	protein kinase D3	827	Protein kinase.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			breast(3)|central_nervous_system(2)|kidney(3)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33		all_hematologic(82;0.21)				GGATGACTAAGAGATTTGTCA	0.368000													23	30					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73849756	73849756	+	Silent	SNP	T	T	C	rs114148959	byFrequency	TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr8:73849756T>C	ENST00000523207.1	+	3	2754	c.2166T>C	c.(2164-2166)aaT>aaC	p.N722N		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	722					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			TTAAGGAAAATAGAGGCAGTG	0.537000													64	54					0	0	1	0	0
CASP2	835	broad.mit.edu	37	7	142985599	142985599	+	Silent	SNP	G	G	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr7:142985599G>T	ENST00000310447.5	+	1	292	c.51G>T	c.(49-51)ctG>ctT	p.L17L	CASP2_ENST00000392925.2_Silent_p.L17L	NM_032982.3|NM_032983.3	NP_116764.2|NP_116765.2	P42575	CASP2_HUMAN	caspase 2, apoptosis-related cysteine peptidase	17					apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|protein maturation by peptide bond cleavage	cytosol	cysteine-type endopeptidase activity|enzyme binding|protein binding|protein domain specific binding			endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)	21	Melanoma(164;0.059)					ACAAGGAGCTGATGGCCGCTG	0.682000													4	14					0.00198382	0.00202758	1	1	0
KIAA1109	84162	broad.mit.edu	37	4	123161005	123161005	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr4:123161005G>A	ENST00000264501.4	+	29	4541	c.4168G>A	c.(4168-4170)Gat>Aat	p.D1390N	KIAA1109_ENST00000495260.1_3'UTR|KIAA1109_ENST00000455637.1_Missense_Mutation_p.D1390N|KIAA1109_ENST00000388738.3_Missense_Mutation_p.D1390N			Q2LD37	K1109_HUMAN	KIAA1109	1390					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						GTCAATGGCTGATAGTGAAGC	0.418000													19	33					0	0	1	0	0
ATAD5	79915	broad.mit.edu	37	17	29162843	29162843	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:29162843G>A	ENST00000321990.4	+	2	2122	c.1744G>A	c.(1744-1746)Gaa>Aaa	p.E582K	CTD-2349P21.11_ENST00000580873.1_RNA	NM_024857.3	NP_079133.3	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	582					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(18)|lung(13)|ovary(3)|pancreas(1)	51		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				AGCTGAATCTGAAGCCAGCTT	0.378000													15	55					0	0	1	0	0
KCNJ2	3759	broad.mit.edu	37	17	68171221	68171221	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:68171221C>T	ENST00000243457.3	+	2	424	c.41C>T	c.(40-42)tCa>tTa	p.S14L	KCNJ2_ENST00000535240.1_Missense_Mutation_p.S14L	NM_000891.2	NP_000882.1	P63252	IRK2_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 2	14					synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(13)|skin(1)|urinary_tract(1)	25	Breast(10;1.64e-08)					ATCGTCTCTTCAGAAGAAGAC	0.517000													19	22					0	0	1	0	0
MAGEA3	4102	broad.mit.edu	37	X	151935357	151935357	+	Silent	SNP	T	T	C	rs35014597	byFrequency	TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chrX:151935357T>C	ENST00000393902.3	-	3	1377	c.810A>G	c.(808-810)gaA>gaG	p.E270E	MAGEA3_ENST00000370278.3_Silent_p.E270E			P43357	MAGA3_HUMAN	melanoma antigen family A, 3	270	MAGE.									endometrium(4)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)	15	Acute lymphoblastic leukemia(192;6.56e-05)					CCCACAGGAATTCATAACATG	0.532000													4	145					0	0	1	0	0
NPY2R	4887	broad.mit.edu	37	4	156135697	156135697	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr4:156135697C>T	ENST00000329476.3	+	2	1095	c.606C>T	c.(604-606)gcC>gcT	p.A202A	NPY2R_ENST00000506608.1_Silent_p.A202A	NM_000910.2	NP_000901.1	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	202				A -> P (in Ref. 4; AAB07760).	cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(17)|prostate(1)|skin(5)|urinary_tract(1)	36	all_hematologic(180;0.24)	Renal(120;0.0854)				AGATTGTGGCCTGTACTGAAA	0.507000													8	129					0	0	1	0	0
WFS1	7466	broad.mit.edu	37	4	6302887	6302887	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr4:6302887G>A	ENST00000226760.1	+	8	1535	c.1365G>A	c.(1363-1365)acG>acA	p.T455T	WFS1_ENST00000503569.1_Silent_p.T455T	NM_001145853.1|NM_006005.3	NP_001139325.1|NP_005996.2	O76024	WFS1_HUMAN	Wolfram syndrome 1 (wolframin)	455					endoplasmic reticulum calcium ion homeostasis|endoplasmic reticulum unfolded protein response|ER overload response|ER-associated protein catabolic process|glucose homeostasis|kidney development|negative regulation of neuron apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|polyubiquitinated misfolded protein transport|positive regulation of calcium ion transport|positive regulation of growth|positive regulation of protein ubiquitination|positive regulation of proteolysis|protein stabilization|renal water homeostasis|sensory perception of sound|visual perception	dendrite|integral to endoplasmic reticulum membrane	activating transcription factor binding|ATPase binding|transporter activity|ubiquitin protein ligase binding			central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(6)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	21				Colorectal(103;0.0512)		AGCCCTACACGCGCAGGGCCC	0.637000													22	55					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106960946	106960946	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr10:106960946G>A	ENST00000369701.3	+	16	2423	c.2196G>A	c.(2194-2196)ctG>ctA	p.L732L	SORCS3_ENST00000369699.4_Silent_p.L18L	NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	732						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		AGTGTGCCCTGGGCCGAGACC	0.488000													22	45					0	0	1	0	0
FYN	2534	broad.mit.edu	37	6	111983077	111983077	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr6:111983077G>A	ENST00000354650.3	-	14	2085	c.1479C>T	c.(1477-1479)atC>atT	p.I493I	FYN_ENST00000356013.2_Silent_p.I438I|FYN_ENST00000538466.1_Silent_p.I490I|FYN_ENST00000229470.5_Silent_p.I441I|FYN_ENST00000229471.4_Silent_p.I438I|FYN_ENST00000368678.4_Silent_p.I490I|FYN_ENST00000368682.3_Silent_p.I490I|FYN_ENST00000368667.2_Silent_p.I493I	NM_002037.5	NP_002028.1	P06241	FYN_HUMAN	FYN oncogene related to SRC, FGR, YES	493	Protein kinase.				axon guidance|calcium ion transport|feeding behavior|interspecies interaction between organisms|intracellular protein kinase cascade|learning|leukocyte migration|platelet activation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|endosome|plasma membrane	ATP binding|glycoprotein binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(17)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	30		all_cancers(87;1.37e-05)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00125)|Colorectal(196;0.0211)		all cancers(137;0.0451)|OV - Ovarian serous cystadenocarcinoma(136;0.0476)|Epithelial(106;0.102)	Dasatinib(DB01254)	CATGCAGAGAGATGGGGCAGT	0.567000													82	47					0	0	1	0	0
GPN2	54707	broad.mit.edu	37	1	27216470	27216470	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:27216470C>T	ENST00000374135.4	-	1	318	c.118G>A	c.(118-120)Gtg>Atg	p.V40M		NM_018066.3	NP_060536.3	Q9H9Y4	GPN2_HUMAN	GPN-loop GTPase 2	40							GTP binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|urinary_tract(1)	9						ACCACCGCCACGCGCCGGCCC	0.721000													3	12					0	0	1	0	0
CELSR1	9620	broad.mit.edu	37	22	46787591	46787591	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr22:46787591G>A	ENST00000262738.3	-	15	6086	c.6087C>T	c.(6085-6087)atC>atT	p.I2029I		NM_014246.1	NP_055061.1	Q9NYQ6	CELR1_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 1	2029	Laminin EGF-like.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		ACTGGCGGCCGATGACGCCGG	0.682000													4	21					0	0	1	0	0
FOXA2	3170	broad.mit.edu	37	20	22563496	22563496	+	Silent	SNP	G	G	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr20:22563496G>T	ENST00000419308.2	-	2	568	c.384C>A	c.(382-384)ggC>ggA	p.G128G	FOXA2_ENST00000377115.4_Silent_p.G122G	NM_021784.4	NP_068556.2	Q9Y261	FOXA2_HUMAN	forkhead box A2	128					cell differentiation in hindbrain|central nervous system myelin formation|chromatin modification|dorsal/ventral neural tube patterning|ectoderm formation|endocrine pancreas development|endoderm development|epithelial tube branching involved in lung morphogenesis|in utero embryonic development|lung epithelial cell differentiation|negative regulation of neuron differentiation|neuron fate specification|oligodendrocyte cell fate commitment|positive regulation of embryonic development|positive regulation of gastrulation|positive regulation of neuron differentiation|primitive streak formation|regulation of blood coagulation|regulation of sequence-specific DNA binding transcription factor activity|response to interleukin-6	cytoplasm|transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(1)|lung(3)|ovary(2)|prostate(2)|urinary_tract(1)	22	Lung NSC(19;0.188)					GGGCCAGGCCGCCCATGGCCC	0.756000													4	19					0.00024832	0.000256628	1	1	0
SCAF8	22828	broad.mit.edu	37	6	155154524	155154524	+	Missense_Mutation	SNP	A	A	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr6:155154524A>G	ENST00000367178.3	+	20	4387	c.3811A>G	c.(3811-3813)Aca>Gca	p.T1271A	SCAF8_ENST00000417268.1_Missense_Mutation_p.T1271A|SCAF8_ENST00000367186.4_Missense_Mutation_p.T1337A|TIAM2_ENST00000461783.3_5'UTR	NM_014892.3	NP_055707.3	Q9UPN6	SCAF8_HUMAN	SR-related CTD-associated factor 8	1271					mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding			breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(15)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	46						AACTGAGGGGACATAATCATC	0.373000													35	22					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7722612	7722612	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:7722612C>T	ENST00000572933.1	+	72	12361	c.10901C>T	c.(10900-10902)tCa>tTa	p.S3634L	DNAH2_ENST00000389173.2_Missense_Mutation_p.S3634L			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	3634					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TACCAGTTCTCACTGGATGCC	0.542000													14	47					0	0	1	0	0
KRTAP10-3	386682	broad.mit.edu	37	21	45978005	45978005	+	Silent	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr21:45978005G>C	ENST00000391620.1	-	1	638	c.594C>G	c.(592-594)ctC>ctG	p.L198L	TSPEAR_ENST00000323084.4_Intron|TSPEAR_ENST00000397916.1_Intron	NM_198696.2	NP_941969.2	P60369	KR103_HUMAN	keratin associated protein 10-3	198	18 X 5 AA repeats of C-C-X(3).					keratin filament				kidney(1)|lung(4)|prostate(1)|skin(1)	7						TGGGGCGGCAGAGGAGGGACA	0.692000													7	32					0	0	1	0	0
SPACA3	124912	broad.mit.edu	37	17	31322626	31322626	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:31322626C>T	ENST00000580599.1	+	3	436	c.27C>T	c.(25-27)ctC>ctT	p.L9L	SPACA3_ENST00000269053.3_Silent_p.L78L|SPACA3_ENST00000394637.2_3'UTR|SPACA3_ENST00000394638.1_Intron			Q8IXA5	SACA3_HUMAN	sperm acrosome associated 3	78					cell wall macromolecule catabolic process|defense response to Gram-positive bacterium|monocyte activation|peptidoglycan catabolic process|positive regulation of macrophage activation|positive regulation of phagocytosis|response to virus	acrosomal membrane|extracellular region|integral to membrane|lysosome	bacterial cell surface binding|lysozyme activity|protein binding			breast(1)|endometrium(1)|large_intestine(3)|lung(10)|ovary(2)|urinary_tract(1)	18			BRCA - Breast invasive adenocarcinoma(9;0.193)			TCTGTCTGCTCAGCTGCCTGC	0.622000													17	47					0	0	1	0	0
BTG3	10950	broad.mit.edu	37	21	18977218	18977218	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr21:18977218C>A	ENST00000339775.6	-	3	424	c.271G>T	c.(271-273)Gag>Tag	p.E91*	BTG3_ENST00000348354.6_Nonsense_Mutation_p.E91*	NM_001130914.1	NP_001124386.1	Q14201	BTG3_HUMAN	BTG family, member 3	91					negative regulation of cell proliferation|negative regulation of mitotic cell cycle	cytoplasm				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)	8				Epithelial(23;0.000283)|all cancers(11;0.0012)|Lung(58;0.0191)|OV - Ovarian serous cystadenocarcinoma(11;0.0206)|COAD - Colon adenocarcinoma(22;0.0315)|LUSC - Lung squamous cell carcinoma(23;0.0703)|Colorectal(24;0.0971)		AGAGTGAGCTCCTTTGGCAAG	0.448000													19	26					2.39187e-15	2.60761e-15	1	1	0
AHNAK2	113146	broad.mit.edu	37	14	105409457	105409457	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr14:105409457C>T	ENST00000333244.5	-	7	12450	c.12331G>A	c.(12331-12333)Gat>Aat	p.D4111N	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4111						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TGCACACCATCCAGCTTTGCT	0.577000													17	332					0	0	1	0	0
NELFB	25920	broad.mit.edu	37	9	140151344	140151344	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr9:140151344G>A	ENST00000343053.4	+	4	772	c.435G>A	c.(433-435)gtG>gtA	p.V145V		NM_015456.3	NP_056271.2			negative elongation factor complex member B																		CCGTGGAGGTGAAGCGGCAGA	0.567000													7	35					0	0	1	0	0
MPP2	4355	broad.mit.edu	37	17	41958843	41958843	+	Missense_Mutation	SNP	C	C	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:41958843C>A	ENST00000269095.4	-	7	1100	c.796G>T	c.(796-798)Gat>Tat	p.D266Y	MPP2_ENST00000461854.1_Missense_Mutation_p.D290Y|MPP2_ENST00000518766.1_Missense_Mutation_p.D311Y|MPP2_ENST00000520305.1_Missense_Mutation_p.D127Y|MPP2_ENST00000377184.3_Missense_Mutation_p.D283Y|MPP2_ENST00000536246.1_Missense_Mutation_p.D255Y|MPP2_ENST00000523501.1_Missense_Mutation_p.D255Y	NM_001278370.1|NM_001278381.1|NM_005374.3	NP_001265299.1|NP_001265310.1|NP_005365	Q14168	MPP2_HUMAN	membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)	290	SH3.				signal transduction	cell surface|integral to plasma membrane|membrane fraction	guanylate kinase activity			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|liver(1)|lung(4)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)	29		Breast(137;0.00314)		BRCA - Breast invasive adenocarcinoma(366;0.12)		CAGTTGGCATCATCCTGGTTT	0.627000													37	75					1.30916e-28	1.46164e-28	1	1	0
HIST1H2BL	8340	broad.mit.edu	37	6	27775577	27775577	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr6:27775577C>T	ENST00000377401.2	-	1	132	c.108G>A	c.(106-108)gaG>gaA	p.E36E		NM_003519.3	NP_003510.1	Q99880	H2B1L_HUMAN	histone cluster 1, H2bl	36					nucleosome assembly	nucleosome|nucleus	DNA binding			cervix(1)|endometrium(1)|large_intestine(2)|lung(7)|urinary_tract(1)	12						CGGAGTAGCTCTCCTTGCGGC	0.587000													77	191					0	0	1	0	0
GRHL3	57822	broad.mit.edu	37	1	24664503	24664503	+	Missense_Mutation	SNP	G	G	A	rs141594535		TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:24664503G>A	ENST00000361548.4	+	7	1092	c.862G>A	c.(862-864)Gac>Aac	p.D288N	GRHL3_ENST00000236255.4_Missense_Mutation_p.D293N|GRHL3_ENST00000342072.4_Missense_Mutation_p.D195N|GRHL3_ENST00000356046.2_Missense_Mutation_p.D242N|GRHL3_ENST00000350501.5_Missense_Mutation_p.D288N	NM_198173.2	NP_937816.1	Q8TE85	GRHL3_HUMAN	grainyhead-like 3 (Drosophila)	288					regulation of actin cytoskeleton organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(3)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00171)|all_lung(284;0.00226)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;8.72e-25)|Colorectal(126;4.38e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00377)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.143)		GGTTGTCTTCGACAATGAGAA	0.572000													35	69					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49435941	49435941	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr12:49435941G>A	ENST00000301067.7	-	28	6039	c.6040C>T	c.(6040-6042)Cag>Tag	p.Q2014*		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		GTGGACAGCTGGCCCAACTCC	0.577000													11	13					0	0	1	0	0
ZNF335	63925	broad.mit.edu	37	20	44579207	44579207	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr20:44579207G>A	ENST00000322927.2	-	21	3317	c.3217C>T	c.(3217-3219)Cgg>Tgg	p.R1073W	ZNF335_ENST00000426788.1_Missense_Mutation_p.R918W	NM_022095.3	NP_071378.1	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	1073					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(13)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	51		Myeloproliferative disorder(115;0.0122)				TGGTGGGGCCGTAGGCTTGAG	0.582000													6	289					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23887583	23887583	+	Silent	SNP	C	C	T	rs144465613	byFrequency	TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr14:23887583C>T	ENST00000355349.3	-	30	4167	c.4005G>A	c.(4003-4005)tcG>tcA	p.S1335S		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1335					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.S1335S(3)		NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CATGCCGGGCCGACTGCAGTG	0.662000													3	57					0	0	1	0	0
KCNU1	157855	broad.mit.edu	37	8	36642052	36642052	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr8:36642052C>T	ENST00000399881.3	+	1	161	c.124C>T	c.(124-126)Ctg>Ttg	p.L42L		NM_001031836.2	NP_001027006.2	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	42						voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(31)|ovary(1)|urinary_tract(1)	57				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		ACTCATCATCCTGTTGATCTT	0.428000													8	19					0	0	1	0	0
KRT16P2	400578	broad.mit.edu	37	17	16735627	16735627	+	RNA	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:16735627C>T	ENST00000579062.1	-	0	261																											CGGATCTTCACTTCCAGGTCG	0.597000													33	140					0	0	1	0	0
LOC101927060	101927060	broad.mit.edu	37	17	45127107	45127107	+	RNA	SNP	C	C	G	rs147409399	by1000genomes	TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:45127107C>G	ENST00000575173.1	-	0	418																											CCTTCGTTCACCCAAGAGCAT	0.592000													4	67					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144882724	144882724	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:144882724G>A	ENST00000369359.4	-	27	3744	c.3706C>T	c.(3706-3708)Cag>Tag	p.Q1236*	PDE4DIP_ENST00000369356.4_Nonsense_Mutation_p.Q1099*|PDE4DIP_ENST00000530740.1_Nonsense_Mutation_p.Q1236*|PDE4DIP_ENST00000524974.1_5'UTR|PDE4DIP_ENST00000313382.9_Intron|PDE4DIP_ENST00000369354.3_Nonsense_Mutation_p.Q1099*			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	1099					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		AACTCAGCCTGAAGGCTACTC	0.483000			T	PDGFRB	MPD								38	208					0	0	1	0	0
GABPA	2551	broad.mit.edu	37	21	27130452	27130452	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr21:27130452G>T	ENST00000354828.3	+	6	1212	c.685G>T	c.(685-687)Gat>Tat	p.D229Y	GABPA_ENST00000400075.3_Missense_Mutation_p.D229Y	NM_001197297.1	NP_001184226.1	Q06546	GABPA_HUMAN	GA binding protein transcription factor, alpha subunit 60kDa	229	PNT.				positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(5)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	24						CAACCAAGAAGATTTTTTTCA	0.398000													16	42					8.10497e-08	8.53478e-08	1	1	0
HORMAD1	84072	broad.mit.edu	37	1	150679139	150679139	+	Nonsense_Mutation	SNP	G	G	A	rs150156011		TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:150679139G>A	ENST00000368993.2	-	10	799	c.694C>T	c.(694-696)Cga>Tga	p.R232*	HORMAD1_ENST00000322343.7_Nonsense_Mutation_p.R225*|HORMAD1_ENST00000361824.2_Nonsense_Mutation_p.R232*|HORMAD1_ENST00000368995.4_Nonsense_Mutation_p.R152*			Q86X24	HORM1_HUMAN	HORMA domain containing 1	232					blastocyst development|cell differentiation|meiotic DNA double-strand break formation|meiotic recombination checkpoint|meiotic sister chromatid cohesion|mitosis|oogenesis|regulation of homologous chromosome segregation|spermatogenesis|synaptonemal complex assembly	chromosome|nucleus				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(3)|lung(4)|ovary(3)	16	all_cancers(9;3.23e-52)|all_epithelial(9;4.68e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.0009)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;2.32e-23)|all cancers(9;5.21e-23)|OV - Ovarian serous cystadenocarcinoma(6;6.72e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			TTTTCCATTCGTTCTCTCTCA	0.353000													18	64					0	0	1	0	0
RXRG	6258	broad.mit.edu	37	1	165398029	165398029	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:165398029G>T	ENST00000359842.5	-	2	526	c.224C>A	c.(223-225)tCt>tAt	p.S75Y		NM_001256570.1|NM_006917.4	NP_001243499.1|NP_008848.1	P48443	RXRG_HUMAN	retinoid X receptor, gamma	75	Modulating (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(6)|lung(22)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	38	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)	GCCCATGGCAGAGGTGATGAC	0.602000													18	28					4.63292e-17	5.09072e-17	1	1	0
ATP7B	540	broad.mit.edu	37	13	52544680	52544680	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr13:52544680C>T	ENST00000242839.4	-	3	1647	c.1491G>A	c.(1489-1491)atG>atA	p.M497I	ATP7B_ENST00000418097.2_Missense_Mutation_p.M497I|ATP7B_ENST00000400370.3_Intron|ATP7B_ENST00000482841.1_5'UTR|ATP7B_ENST00000448424.2_Missense_Mutation_p.M497I|ATP7B_ENST00000542656.1_Missense_Mutation_p.M465I|ATP7B_ENST00000400366.3_Missense_Mutation_p.M386I|ATP7B_ENST00000344297.5_Missense_Mutation_p.M497I	NM_000053.3	NP_000044.2	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	497	HMA 5.				ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(23)|ovary(1)|prostate(3)|skin(4)|stomach(2)	55		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		ATGCACAGGTCATGCCTTTGA	0.502000									Wilson disease				63	106					0	0	1	0	0
WDR11	55717	broad.mit.edu	37	10	122648591	122648591	+	Splice_Site	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr10:122648591G>A	ENST00000263461.6	+	17	2369	c.2123G>A	c.(2122-2124)gGa>gAa	p.G708E	WDR11_ENST00000604509.1_3'UTR	NM_018117.11	NP_060587.8	Q9BZH6	WDR11_HUMAN	WD repeat domain 11	708						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(9)|prostate(2)|skin(2)|stomach(5)	38						GTTTTCTAGGGAAGTATGGGT	0.318000													30	57					0	0	1	0	0
SNX31	169166	broad.mit.edu	37	8	101629926	101629926	+	Silent	SNP	A	A	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr8:101629926A>G	ENST00000311812.2	-	5	504	c.354T>C	c.(352-354)taT>taC	p.Y118Y	SNX31_ENST00000428383.2_Silent_p.Y19Y	NM_152628.3	NP_689841.3	Q8N9S9	SNX31_HUMAN	sorting nexin 31	118					cell communication|protein transport		phosphatidylinositol binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|skin(3)|urinary_tract(1)	26	all_cancers(14;4.01e-05)|all_epithelial(15;1.26e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;1.21e-11)|all cancers(13;2.62e-09)|OV - Ovarian serous cystadenocarcinoma(57;3.22e-06)|STAD - Stomach adenocarcinoma(118;0.206)			ATATGTCCAGATAAGCTTTCT	0.358000													32	105					0	0	1	0	0
SORCS1	114815	broad.mit.edu	37	10	108371675	108371675	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr10:108371675C>T	ENST00000263054.6	-	22	3034	c.3027G>A	c.(3025-3027)ctG>ctA	p.L1009L	SORCS1_ENST00000478809.2_5'UTR|SORCS1_ENST00000369698.1_Silent_p.L544L|SORCS1_ENST00000344440.6_Silent_p.L1009L	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	1009						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		TCACTTCCACCAGGGATTTTT	0.483000													6	23					0	0	1	0	0
MOK	5891	broad.mit.edu	37	14	102729905	102729905	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr14:102729905C>T	ENST00000361847.2	-	4	492	c.261G>A	c.(259-261)atG>atA	p.M87I	MOK_ENST00000522874.1_Missense_Mutation_p.M87I|MOK_ENST00000193029.6_5'UTR|MOK_ENST00000524214.1_Missense_Mutation_p.M57I	NM_014226.1	NP_055041.1	Q9UQ07	MOK_HUMAN	MOK protein kinase	87	Protein kinase.				signal transduction	Golgi apparatus	ATP binding|cyclin-dependent protein kinase activity|protein binding										CATAAATATTCATGTCCATAA	0.308000													10	33					0	0	1	0	0
CYP2B6	1555	broad.mit.edu	37	19	41518309	41518309	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:41518309G>C	ENST00000324071.4	+	7	1078	c.1071G>C	c.(1069-1071)caG>caC	p.Q357H	CYP2B6_ENST00000330446.5_Missense_Mutation_p.Q157H|CYP2B6_ENST00000593831.1_Missense_Mutation_p.Q121H	NM_000767.4	NP_000758.1	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B, polypeptide 6	357					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			NS(1)|breast(1)|endometrium(5)|kidney(1)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	28			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	ATGAGATTCAGAGATTTTCCG	0.537000													26	45					0	0	1	0	0
MED15	51586	broad.mit.edu	37	22	20909408	20909408	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr22:20909408G>T	ENST00000263205.7	+	5	493	c.424G>T	c.(424-426)Gct>Tct	p.A142S	MED15_ENST00000406969.1_Missense_Mutation_p.A116S|MED15_ENST00000542773.1_Intron|MED15_ENST00000292733.7_Missense_Mutation_p.A142S|MED15_ENST00000425759.2_Intron|MED15_ENST00000382974.2_Intron|MED15_ENST00000541476.1_Missense_Mutation_p.A116S	NM_001003891.1	NP_001003891.1	Q96RN5	MED15_HUMAN	mediator complex subunit 15	142					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|mediator complex	protein binding			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	25	all_cancers(11;2.07e-24)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)|Epithelial(17;0.209)			TCACAGCATGGCTGTCGTGTC	0.567000													3	6					2.56e-06	2.66547e-06	1	1	0
KMT2C	58508	broad.mit.edu	37	7	151949045	151949045	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr7:151949045C>A	ENST00000355193.2	-	11	1818	c.1600G>T	c.(1600-1602)Gag>Tag	p.E534*	KMT2C_ENST00000262189.6_Nonsense_Mutation_p.E534*					lysine (K)-specific methyltransferase 2C																		TCAGCTATCTCCACTTCCTCA	0.358000													9	16					2.27111e-07	2.37357e-07	1	1	0
GPALPP1	55425	broad.mit.edu	37	13	45580434	45580434	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr13:45580434C>G	ENST00000361121.2	+	3	354	c.319C>G	c.(319-321)Cca>Gca	p.P107A	GPALPP1_ENST00000379151.4_Missense_Mutation_p.P107A|GPALPP1_ENST00000357537.3_5'UTR|RP11-321C24.1_ENST00000437748.2_lincRNA					GPALPP motifs containing 1	107																	TGATTCTCCTCCAAGGTGATA	0.328000													39	124					0	0	1	0	0
N4BP2	55728	broad.mit.edu	37	4	40104376	40104376	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr4:40104376G>A	ENST00000261435.6	+	4	1327	c.911G>A	c.(910-912)gGt>gAt	p.G304D		NM_018177.4	NP_060647.2	Q86UW6	N4BP2_HUMAN	NEDD4 binding protein 2	304						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			breast(4)|endometrium(3)|kidney(12)|large_intestine(7)|liver(2)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	60						GATTTACCAGGTACAGGTGGG	0.473000													22	51					0	0	1	0	0
MSH3	4437	broad.mit.edu	37	5	79950579	79950579	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr5:79950579C>T	ENST00000265081.6	+	1	113	c.33C>T	c.(31-33)ctC>ctT	p.L11L	DHFR_ENST00000439211.2_5'UTR	NM_002439.4	NP_002430.3	P20585	MSH3_HUMAN	mutS homolog 3	11					maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	29		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)		CGGGCGGCCTCGCTGCCTCCA	0.697000								Mismatch excision repair (MMR)					9	25					0	0	1	0	0
ZNF695	57116	broad.mit.edu	37	1	247151490	247151490	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:247151490C>T	ENST00000339986.7	-	4	474	c.327G>A	c.(325-327)gtG>gtA	p.V109V	ZNF695_ENST00000498046.2_5'UTR|ZNF695_ENST00000487338.2_Silent_p.V109V	NM_020394.4	NP_065127	Q8IW36	ZN695_HUMAN	zinc finger protein 695	109					regulation of transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			endometrium(1)|large_intestine(1)|lung(9)|prostate(1)|urinary_tract(1)	13	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			TTCTCAGCATCACTTTTTGGA	0.373000													27	54					0	0	1	0	0
ABCC1	4363	broad.mit.edu	37	16	16180769	16180769	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr16:16180769C>T	ENST00000399408.2	+	18	2556	c.2381C>T	c.(2380-2382)cCc>cTc	p.P794L	ABCC1_ENST00000351154.5_Missense_Mutation_p.P735L|ABCC1_ENST00000345148.5_Missense_Mutation_p.P794L|ABCC1_ENST00000346370.5_Intron|ABCC1_ENST00000349029.5_Intron|ABCC1_ENST00000399410.3_Missense_Mutation_p.P794L			P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	794	ABC transporter 1.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(5)|prostate(1)|skin(3)	56					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	TTCGATGATCCCCTCTCAGCA	0.597000													18	59					0	0	1	0	0
CCDC102B	79839	broad.mit.edu	37	18	66504371	66504371	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr18:66504371G>A	ENST00000360242.5	+	2	488	c.371G>A	c.(370-372)aGa>aAa	p.R124K	CCDC102B_ENST00000584156.1_Missense_Mutation_p.R124K|CCDC102B_ENST00000319445.6_Missense_Mutation_p.R124K|CCDC102B_ENST00000577772.1_3'UTR|CCDC102B_ENST00000358653.5_Missense_Mutation_p.R124K	NM_024781.2	NP_079057	Q68D86	C102B_HUMAN	coiled-coil domain containing 102B	124										breast(2)|endometrium(3)|large_intestine(5)|lung(19)|ovary(1)|skin(5)|stomach(1)	36		Esophageal squamous(42;0.0559)|Colorectal(73;0.0604)				AGACAACTCAGAATAAAACTA	0.458000													18	29					0	0	1	0	0
ACE	1636	broad.mit.edu	37	17	61566090	61566090	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:61566090G>C	ENST00000577647.1	+	5	710	c.665G>C	c.(664-666)aGa>aCa	p.R222T	ACE_ENST00000490216.2_Missense_Mutation_p.R222T|ACE_ENST00000290866.4_Missense_Mutation_p.R796T|ACE_ENST00000428043.1_Missense_Mutation_p.R796T|ACE_ENST00000421982.2_Missense_Mutation_p.R106T|ACE_ENST00000413513.3_Missense_Mutation_p.R222T|ACE_ENST00000290863.6_Missense_Mutation_p.R222T			P12821	ACE_HUMAN	angiotensin I converting enzyme	796	Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(3)|lung(22)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	51					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	AAGGCGGGGAGAGCCATCCTC	0.562000													30	45					0	0	1	0	0
NLRP2	55655	broad.mit.edu	37	19	55494608	55494608	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:55494608C>G	ENST00000543010.1	+	6	1685	c.1542C>G	c.(1540-1542)ttC>ttG	p.F514L	NLRP2_ENST00000339757.7_Missense_Mutation_p.F492L|NLRP2_ENST00000391721.4_Missense_Mutation_p.F490L|NLRP2_ENST00000263437.6_Missense_Mutation_p.F511L|NLRP2_ENST00000537859.1_Missense_Mutation_p.F492L|NLRP2_ENST00000427260.2_Missense_Mutation_p.F491L|NLRP2_ENST00000448584.2_Missense_Mutation_p.F514L|NLRP2_ENST00000538819.1_Missense_Mutation_p.F490L	NM_001174081.1	NP_001167552.1	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	514	NACHT.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		CTGCCCTGTTCTACACCCTGG	0.562000													31	49					0	0	1	0	0
TAF7L	54457	broad.mit.edu	37	X	100524223	100524223	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chrX:100524223G>A	ENST00000372907.3	-	13	1358	c.1347C>T	c.(1345-1347)ctC>ctT	p.L449L	TAF7L_ENST00000372905.2_Silent_p.L289L|TAF7L_ENST00000356784.1_Silent_p.L363L|TAF7L_ENST00000324762.6_Silent_p.L289L	NM_024885.3	NP_079161.3	Q5H9L4	TAF7L_HUMAN	TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa	449					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription initiation from RNA polymerase II promoter	cytoplasm|transcription factor TFIID complex	binding			NS(1)|breast(4)|kidney(4)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	29						GTAGGGAAATGAGCTGTAGGG	0.418000													12	61					0	0	1	0	0
PAK3	5063	broad.mit.edu	37	X	110439755	110439755	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chrX:110439755G>A	ENST00000372007.5	+	16	1685	c.1294G>A	c.(1294-1296)Gag>Aag	p.E432K	PAK3_ENST00000518291.1_Missense_Mutation_p.E468K|PAK3_ENST00000446737.1_Missense_Mutation_p.E432K|PAK3_ENST00000372010.1_Missense_Mutation_p.E447K|PAK3_ENST00000425146.1_Missense_Mutation_p.E432K|PAK3_ENST00000519681.1_Missense_Mutation_p.E453K|PAK3_ENST00000262836.4_Missense_Mutation_p.E447K|PAK3_ENST00000360648.4_Missense_Mutation_p.E468K|PAK3_ENST00000417227.1_Missense_Mutation_p.E453K	NM_002578.3	NP_002569.1	O75914	PAK3_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 3		Protein kinase.				multicellular organismal development		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding			breast(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(7)|lung(15)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	41						GATGGCACCTGAGGTGGTGAC	0.468000										TSP Lung(19;0.15)			49	57					0	0	1	0	0
SLC7A4	6545	broad.mit.edu	37	22	21384120	21384120	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr22:21384120C>T	ENST00000382932.2	-	3	1570	c.1503G>A	c.(1501-1503)tcG>tcA	p.S501S	SLC7A4_ENST00000403586.1_Silent_p.S501S	NM_004173.2	NP_004164.2	O43246	CTR4_HUMAN	solute carrier family 7, member 4	501					cellular amino acid metabolic process	integral to membrane	basic amino acid transmembrane transporter activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(7)|ovary(1)|prostate(2)	18	all_cancers(11;2.85e-22)|Lung NSC(8;4.21e-14)|all_lung(8;6.08e-13)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0968)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)		L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	GGTGCAGGGTCGAGTTCCCAA	0.582000													6	25					0	0	1	0	0
DLG2	1740	broad.mit.edu	37	11	84028123	84028123	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr11:84028123C>G	ENST00000280241.8	-	1	65	c.66G>C	c.(64-66)agG>agC	p.R22S	DLG2_ENST00000398301.2_Missense_Mutation_p.R22S|DLG2_ENST00000398309.2_Intron|DLG2_ENST00000524982.1_Intron|DLG2_ENST00000532653.1_Intron|DLG2_ENST00000543673.1_Intron|DLG2_ENST00000376104.2_Intron	NM_001206769.1	NP_001193698.1	Q15700	DLG2_HUMAN	discs, large homolog 2 (Drosophila)	0						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(11)|lung(35)|ovary(3)|pancreas(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	71		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				TGGGCGCACTCCTGACGGCAT	0.587000													90	128					0	0	1	0	0
SPRYD3	84926	broad.mit.edu	37	12	53460407	53460407	+	Missense_Mutation	SNP	A	A	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr12:53460407A>T	ENST00000301463.4	-	9	1057	c.971T>A	c.(970-972)aTc>aAc	p.I324N	SPRYD3_ENST00000547837.1_Missense_Mutation_p.I361N	NM_032840.2	NP_116229.1	Q8NCJ5	SPRY3_HUMAN	SPRY domain containing 3	324										central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	17						ACAGCCCATGATGTCCCCTTT	0.587000											OREG0021856	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	19					0	0	1	0	0
CYP4A22	284541	broad.mit.edu	37	1	47603168	47603168	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:47603168C>G	ENST00000371891.3	+	1	42	c.11C>G	c.(10-12)tCt>tGt	p.S4C	CYP4A22_ENST00000371890.3_Missense_Mutation_p.S4C|CYP4A22_ENST00000294337.3_Missense_Mutation_p.S4C|CYP4A22_ENST00000485117.1_3'UTR|CYP4A22-AS1_ENST00000444042.2_lincRNA	NM_001010969.2	NP_001010969.2	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 22	4						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						ATGAGTGTCTCTGTCCTGAGC	0.597000													28	70					0	0	1	0	0
ATAD5	79915	broad.mit.edu	37	17	29162605	29162605	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:29162605G>C	ENST00000321990.4	+	2	1884	c.1506G>C	c.(1504-1506)aaG>aaC	p.K502N	CTD-2349P21.11_ENST00000580873.1_RNA	NM_024857.3	NP_079133.3	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	502					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(18)|lung(13)|ovary(3)|pancreas(1)	51		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				ACACTCAAAAGAAAGAAACAA	0.303000													12	33					0	0	1	0	0
DNMT1	1786	broad.mit.edu	37	19	10270402	10270402	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:10270402G>C	ENST00000340748.4	-	16	1399	c.1164C>G	c.(1162-1164)atC>atG	p.I388M	DNMT1_ENST00000359526.4_Missense_Mutation_p.I404M|DNMT1_ENST00000540357.1_Missense_Mutation_p.I388M			P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1	388	DNA replication foci-targeting sequence (By similarity).|Homodimerization.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			breast(5)|endometrium(8)|kidney(5)|large_intestine(21)|lung(11)|ovary(2)|pancreas(1)|prostate(10)|skin(5)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	TGGCATCAAAGATGGACAGCT	0.537000													18	60					0	0	1	0	0
CELF3	11189	broad.mit.edu	37	1	151678328	151678328	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:151678328C>T	ENST00000290583.4	-	11	2033	c.1240G>A	c.(1240-1242)Gac>Aac	p.D414N	RP11-98D18.1_ENST00000457548.1_RNA|CELF3_ENST00000290585.4_Missense_Mutation_p.D364N|CELF3_ENST00000392706.3_Missense_Mutation_p.D209N|CELF3_ENST00000470688.1_5'UTR	NM_001172648.1|NM_007185.4	NP_001166119.1|NP_009116.3	Q5SZQ8	CELF3_HUMAN	CUGBP, Elav-like family member 3	414	RRM 3.				nuclear mRNA splicing, via spliceosome|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	mRNA binding|nucleotide binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)	21						GTGGCTCGGTCAACAAAGACT	0.438000													13	30					0	0	1	0	0
ATAD2	29028	broad.mit.edu	37	8	124382256	124382256	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr8:124382256C>T	ENST00000287394.5	-	7	843	c.736G>A	c.(736-738)Gaa>Aaa	p.E246K	ATAD2_ENST00000521903.1_5'UTR	NM_014109.3	NP_054828.2	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	246					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|lung(16)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	48	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			TCACCCTCTTCAGATGACTCT	0.373000													45	44					0	0	1	0	0
FAM83G	644815	broad.mit.edu	37	17	18907093	18907093	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:18907093G>A	ENST00000388995.6	-	2	485	c.262C>T	c.(262-264)Cag>Tag	p.Q88*	FAM83G_ENST00000585154.2_Nonsense_Mutation_p.Q88*|SLC5A10_ENST00000395643.2_Intron|SLC5A10_ENST00000395647.2_Intron|FAM83G_ENST00000345041.4_Nonsense_Mutation_p.Q88*|SLC5A10_ENST00000395642.1_Intron|SLC5A10_ENST00000317977.6_Intron|SLC5A10_ENST00000395645.3_Intron|SLC5A10_ENST00000417251.2_Intron			A6ND36	FA83G_HUMAN	family with sequence similarity 83, member G	88										central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(7)|ovary(2)|prostate(3)|stomach(1)	22						TCGGGCCCCTGAGAGGGGCCC	0.701000													4	4					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227924258	227924258	+	Nonsense_Mutation	SNP	G	G	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:227924258G>T	ENST00000396625.3	-	28	2453	c.2246C>A	c.(2245-2247)tCa>tAa	p.S749*	COL4A4_ENST00000329662.7_Nonsense_Mutation_p.S749*	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	749	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding	p.S749L(1)		breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		CACTCCTGGTGAGCCGGGAGG	0.552000													18	55					2.37509e-13	2.56917e-13	1	1	0
DKK3	27122	broad.mit.edu	37	11	11986170	11986170	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr11:11986170G>A	ENST00000396505.2	-	8	1132	c.894C>T	c.(892-894)atC>atT	p.I298I	DKK3_ENST00000527132.1_Intron|DKK3_ENST00000326932.4_Silent_p.I298I|DKK3_ENST00000525493.1_Silent_p.I312I|DKK3_ENST00000450094.2_Silent_p.I270I	NM_015881.5	NP_056965.3	Q9UBP4	DKK3_HUMAN	dickkopf WNT signaling pathway inhibitor 3	298					adrenal gland development|anatomical structure morphogenesis|negative regulation of aldosterone biosynthetic process|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cortisol biosynthetic process|negative regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	extracellular space				breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|ovary(1)|pancreas(1)	8				Epithelial(150;0.000502)		TGGGCAGCAGGATCTCCCCAT	0.597000													19	13					0	0	1	0	0
UBBP4	23666	broad.mit.edu	37	17	21731075	21731075	+	Missense_Mutation	SNP	T	T	G	rs111568648		TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:21731075T>G	ENST00000584755.1	+	2	774	c.377T>G	c.(376-378)cTg>cGg	p.L126R	UBBP4_ENST00000584398.1_3'UTR|UBBP4_ENST00000583708.1_3'UTR|UBBP4_ENST00000578713.1_Missense_Mutation_p.L126R																endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						GGCAAGCAGCTGGAAGATGGC	0.537000													3	60					0	0	1	0	0
ZNF462	58499	broad.mit.edu	37	9	109688322	109688322	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr9:109688322C>G	ENST00000277225.5	+	3	2418	c.2129C>G	c.(2128-2130)aCc>aGc	p.T710S	ZNF462_ENST00000457913.1_Missense_Mutation_p.T710S			Q96JM2	ZN462_HUMAN	zinc finger protein 462	710					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						ATTAACCAAACCAAACAGCAG	0.453000													36	70					0	0	1	0	0
MRPL1	65008	broad.mit.edu	37	4	78815330	78815330	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr4:78815330C>G	ENST00000315567.8	+	6	925	c.596C>G	c.(595-597)gCt>gGt	p.A199G	MRPL1_ENST00000506674.1_3'UTR	NM_020236.3	NP_064621.3	Q9BYD6	RM01_HUMAN	mitochondrial ribosomal protein L1	199							RNA binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)	17						TTTTACGTAGCTGTTCCAGAA	0.308000													37	75					0	0	1	0	0
PKP2	5318	broad.mit.edu	37	12	33021978	33021978	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr12:33021978C>T	ENST00000340811.4	-	4	1161	c.1053G>A	c.(1051-1053)atG>atA	p.M351I	PKP2_ENST00000070846.6_Missense_Mutation_p.M351I	NM_001005242.2	NP_001005242.2	Q99959	PKP2_HUMAN	plakophilin 2	351					cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			NS(1)|breast(2)|endometrium(1)|kidney(9)|large_intestine(8)|lung(21)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	50	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					GCTCCAGAGTCATCTCCATGT	0.527000													59	54					0	0	1	0	0
MORC2	22880	broad.mit.edu	37	22	31332626	31332626	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr22:31332626C>G	ENST00000397641.3	-	17	2017	c.1609G>C	c.(1609-1611)Gag>Cag	p.E537Q	MORC2_ENST00000215862.4_Missense_Mutation_p.E475Q|MORC2_ENST00000469915.1_5'UTR			Q9Y6X9	MORC2_HUMAN	MORC family CW-type zinc finger 2								ATP binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	21						TCAGAAGCCTCACACCTGTAG	0.493000													40	44					0	0	1	0	0
SRPK2	6733	broad.mit.edu	37	7	104758350	104758350	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr7:104758350C>G	ENST00000357311.3	-	15	2173	c.2002G>C	c.(2002-2004)Gaa>Caa	p.E668Q	SRPK2_ENST00000393651.3_Missense_Mutation_p.E679Q|SRPK2_ENST00000489828.1_Missense_Mutation_p.E668Q	NM_001278273.1|NM_182691.1	NP_001265202.1|NP_872633.1	P78362	SRPK2_HUMAN	SRSF protein kinase 2	668	Protein kinase.				angiogenesis|cell differentiation|intracellular protein kinase cascade|negative regulation of viral genome replication|nuclear speck organization|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of gene expression|positive regulation of neuron apoptosis|positive regulation of viral genome replication|spliceosome assembly	cytoplasm|nucleolus	14-3-3 protein binding|ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|kidney(11)|large_intestine(6)|lung(4)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	35						GGAACCATTTCTAACATCGGG	0.458000													14	31					0	0	1	0	0
GPR101	83550	broad.mit.edu	37	X	136113744	136113744	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chrX:136113744G>A	ENST00000298110.1	-	1	89	c.90C>T	c.(88-90)caC>caT	p.H30H		NM_054021.1	NP_473362.1	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	30						integral to membrane|plasma membrane	G-protein coupled receptor activity			autonomic_ganglia(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(18)|ovary(3)|skin(1)|urinary_tract(1)	42	Acute lymphoblastic leukemia(192;0.000127)					GGATGATGCCGTGGGCCAGGC	0.612000													4	90					0	0	1	0	0
A1BG	1	broad.mit.edu	37	19	58863655	58863655	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:58863655C>G	ENST00000263100.3	-	4	668	c.607G>C	c.(607-609)Gag>Cag	p.E203Q	A1BG-AS1_ENST00000600686.1_RNA|A1BG-AS1_ENST00000595302.1_RNA|CTD-2619J13.8_ENST00000599109.1_RNA|A1BG-AS1_ENST00000593960.1_RNA|A1BG-AS1_ENST00000600379.1_RNA|A1BG-AS1_ENST00000599728.1_RNA|A1BG-AS1_ENST00000593374.1_RNA|A1BG-AS1_ENST00000594950.1_RNA	NM_130786.3	NP_570602.2	P04217	A1BG_HUMAN	alpha-1-B glycoprotein	203	Ig-like V-type 2.					extracellular region				NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|prostate(2)	15		all_cancers(17;3.04e-16)|all_epithelial(17;7.77e-12)|Lung NSC(17;3.25e-05)|Colorectal(82;5.46e-05)|all_lung(17;0.000129)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(17;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0269)		TCACCGAGCTCCTCAATGGTC	0.607000													19	38					0	0	1	0	0
ZBTB24	9841	broad.mit.edu	37	6	109803198	109803198	+	Missense_Mutation	SNP	T	T	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr6:109803198T>C	ENST00000230122.3	-	2	199	c.32A>G	c.(31-33)cAg>cGg	p.Q11R		NM_001164313.1|NM_014797.2	NP_001157785.1|NP_055612.2	O43167	ZBT24_HUMAN	zinc finger and BTB domain containing 24	11	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|skin(1)|stomach(1)	22		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0154)|all cancers(137;0.0216)|OV - Ovarian serous cystadenocarcinoma(136;0.0242)|BRCA - Breast invasive adenocarcinoma(108;0.059)		TACAACAAGCTGCCCAGAAGG	0.443000													29	13					0	0	1	0	0
WDR33	55339	broad.mit.edu	37	2	128477268	128477268	+	Missense_Mutation	SNP	C	C	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:128477268C>A	ENST00000322313.4	-	16	2489	c.2331G>T	c.(2329-2331)atG>atT	p.M777I		NM_018383.4	NP_060853.3	Q9C0J8	WDR33_HUMAN	WD repeat domain 33	777					postreplication repair|spermatogenesis	collagen|nucleus	protein binding			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		GATTCAATCCCATCAGAGGTC	0.602000													4	9					0.00909568	0.00916159	1	1	0
LRRC2	79442	broad.mit.edu	37	3	46592976	46592976	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr3:46592976C>G	ENST00000395905.3	-	2	498	c.106G>C	c.(106-108)Gag>Cag	p.E36Q	LRRC2_ENST00000296144.3_Missense_Mutation_p.E36Q|LRRC2_ENST00000496388.1_Intron	NM_024512.4	NP_078788.2	Q9BYS8	LRRC2_HUMAN	leucine rich repeat containing 2	36										breast(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)	17		Ovarian(412;0.0563)		OV - Ovarian serous cystadenocarcinoma(275;6.37e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00133)|KIRC - Kidney renal clear cell carcinoma(197;0.0214)|Kidney(197;0.0254)		GCGCTCTTCTCAAGCCTTTCC	0.468000													54	23					0	0	1	0	0
UBXN8	7993	broad.mit.edu	37	8	30620854	30620854	+	RNA	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr8:30620854C>T	ENST00000519246.1	+	0	834							O00124	UBXN8_HUMAN	UBX domain protein 8						single fertilization					central_nervous_system(1)|lung(2)	3						TGAAGTCCTACAGCTCACAGG	0.428000													35	28					0	0	1	0	0
TGFBR2	7048	broad.mit.edu	37	3	30713543	30713543	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr3:30713543G>A	ENST00000295754.5	+	4	1250	c.868G>A	c.(868-870)Gag>Aag	p.E290K	TGFBR2_ENST00000359013.4_Missense_Mutation_p.E315K	NM_003242.5	NP_003233.4	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II (70/80kDa)	290	Protein kinase.				activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(15)|lung(10)|ovary(3)|pancreas(12)|skin(1)|stomach(5)|upper_aerodigestive_tract(2)	53						TTGGAAGACAGAGAAGGACAT	0.483000													61	15					0	0	1	0	0
PCDHB11	56125	broad.mit.edu	37	5	140581588	140581588	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr5:140581588G>T	ENST00000354757.3	+	1	2241	c.2241G>T	c.(2239-2241)caG>caT	p.Q747H	PCDHB11_ENST00000536699.1_Missense_Mutation_p.Q382H	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		747					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCTTTCCCAGAGCTACCAGT	0.582000													69	93					2.18481e-45	2.4491e-45	1	1	0
CAPN13	92291	broad.mit.edu	37	2	30976054	30976054	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:30976054G>C	ENST00000295055.8	-	10	1128	c.952C>G	c.(952-954)Caa>Gaa	p.Q318E	CAPN13_ENST00000534090.2_Missense_Mutation_p.Q318E	NM_144575.2	NP_653176.2	Q6MZZ7	CAN13_HUMAN	calpain 13	318	Calpain catalytic.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(1)	30	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					TGGAAATCTTGACACGACATC	0.453000													21	45					0	0	1	0	0
KLHL13	90293	broad.mit.edu	37	X	117053581	117053581	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chrX:117053581G>C	ENST00000371876.1	-	3	2741	c.320C>G	c.(319-321)tCt>tGt	p.S107C	KLHL13_ENST00000371882.1_Missense_Mutation_p.S107C|KLHL13_ENST00000539496.1_Missense_Mutation_p.S161C|KLHL13_ENST00000541812.1_Missense_Mutation_p.S142C|KLHL13_ENST00000262820.3_Missense_Mutation_p.S158C|KLHL13_ENST00000540167.1_Missense_Mutation_p.S142C|KLHL13_ENST00000469946.1_Missense_Mutation_p.S107C|KLHL13_ENST00000545703.1_Missense_Mutation_p.S116C|KLHL13_ENST00000371878.1_Missense_Mutation_p.S107C			Q9P2N7	KLH13_HUMAN	kelch-like family member 13	158	BTB.				cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						CATATTAAGAGAAAGCTTTGC	0.383000													23	43					0	0	1	0	0
ARID4B	51742	broad.mit.edu	37	1	235331917	235331917	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:235331917C>T	ENST00000264183.3	-	24	4359	c.3862G>A	c.(3862-3864)Gct>Act	p.A1288T	ARID4B_ENST00000349213.3_Missense_Mutation_p.A1202T|ARID4B_ENST00000366603.2_Missense_Mutation_p.A1288T	NM_016374.5	NP_057458.4	Q4LE39	ARI4B_HUMAN	AT rich interactive domain 4B (RBP1-like)	1288	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			NS(1)|breast(2)|large_intestine(2)|lung(1)|ovary(2)	8	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)			ATAACAGCAGCTGTTATGGAA	0.428000													14	28					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179497730	179497730	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:179497730G>A	ENST00000589042.1	-	234	43352	c.43128C>T	c.(43126-43128)atC>atT	p.I14376I	TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000342992.6_Silent_p.I11808I|TTN_ENST00000359218.5_Silent_p.I5436I|TTN_ENST00000342175.6_Silent_p.I5503I|TTN_ENST00000591111.1_Silent_p.I12735I|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000460472.2_Silent_p.I5311I	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	12735							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGTTATGAAGGATCAGAATAT	0.408000													20	19					0	0	1	0	0
ARIH2	10425	broad.mit.edu	37	3	49012253	49012253	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr3:49012253C>T	ENST00000356401.4	+	10	1231	c.892C>T	c.(892-894)Ccc>Tcc	p.P298S	ARIH2_ENST00000490095.1_3'UTR|ARIH2_ENST00000449376.1_Missense_Mutation_p.P298S	NM_006321.2	NP_006312.1	O95376	ARI2_HUMAN	ariadne RBR E3 ubiquitin protein ligase 2	298					developmental cell growth|hemopoietic stem cell proliferation|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)	13				BRCA - Breast invasive adenocarcinoma(193;9.42e-05)|Kidney(197;0.00258)|KIRC - Kidney renal clear cell carcinoma(197;0.00269)		TCCTCAGTGTCCCAAGTGCAA	0.498000													42	8					0	0	1	0	0
RNASE13	440163	broad.mit.edu	37	14	21502251	21502251	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr14:21502251G>A	ENST00000382951.3	-	2	334	c.197C>T	c.(196-198)tCa>tTa	p.S66L	NDRG2_ENST00000403829.3_Intron	NM_001012264.3	NP_001012264.1	Q5GAN3	RNS13_HUMAN	ribonuclease, RNase A family, 13 (non-active)	66						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			cervix(1)|endometrium(1)|lung(5)|ovary(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	12	all_cancers(95;0.000759)		OV - Ovarian serous cystadenocarcinoma(11;6.85e-11)|Epithelial(56;9.49e-09)|all cancers(55;3.84e-08)	GBM - Glioblastoma multiforme(265;0.019)		TGGGCAATCTGAATTTTGCAT	0.428000													44	37					0	0	1	0	0
CNOT6L	246175	broad.mit.edu	37	4	78650191	78650191	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr4:78650191C>T	ENST00000504123.1	-	10	1199	c.1069G>A	c.(1069-1071)Gca>Aca	p.A357T	CNOT6L_ENST00000264903.4_Missense_Mutation_p.A357T			Q96LI5	CNO6L_HUMAN	CCR4-NOT transcription complex, subunit 6-like	357					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	exonuclease activity|protein binding	p.A357T(1)|p.A386T(1)		kidney(1)|large_intestine(1)|lung(6)|urinary_tract(1)	9						TGGGCATTTGCCACTATAAGC	0.388000													23	61					0	0	1	0	0
MKRN1	23608	broad.mit.edu	37	7	140158900	140158900	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr7:140158900C>T	ENST00000255977.2	-	4	902	c.678G>A	c.(676-678)gaG>gaA	p.E226E	MKRN1_ENST00000480552.1_Intron|MKRN1_ENST00000443720.2_Silent_p.E226E|MKRN1_ENST00000474576.1_Silent_p.E162E|MKRN1_ENST00000437223.2_Intron	NM_013446.3	NP_038474.2	Q9UHC7	MKRN1_HUMAN	makorin ring finger protein 1	226							ligase activity|nucleic acid binding|protein binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|skin(1)	16	Melanoma(164;0.00956)					ACACACAGTTCTCCCCGTATC	0.532000													43	97					0	0	1	0	0
GDF2	2658	broad.mit.edu	37	10	48414156	48414156	+	Missense_Mutation	SNP	C	C	T	rs137873272		TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr10:48414156C>T	ENST00000249598.1	-	2	871	c.712G>A	c.(712-714)Gac>Aac	p.D238N		NM_016204.1	NP_057288.1	Q9UK05	GDF2_HUMAN	growth differentiation factor 2	238					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			breast(1)|endometrium(2)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	28						TCCAGCGTGTCGCAGCCCTTC	0.577000													14	21					0	0	1	0	0
ZFP42	132625	broad.mit.edu	37	4	188924685	188924685	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr4:188924685G>A	ENST00000326866.4	+	4	1132	c.724G>A	c.(724-726)Gag>Aag	p.E242K	ZFP42_ENST00000509524.1_Missense_Mutation_p.E242K	NM_174900.3	NP_777560.2	Q96MM3	ZFP42_HUMAN	ZFP42 zinc finger protein	242					female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		TCATACTGGAGAGAAGCCGTT	0.512000													15	27					0	0	1	0	0
HELZ	9931	broad.mit.edu	37	17	65141908	65141908	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:65141908C>T	ENST00000358691.5	-	21	2886	c.2720G>A	c.(2719-2721)gGa>gAa	p.G907E	HELZ_ENST00000580168.1_Missense_Mutation_p.G908E	NM_014877.3	NP_055692			helicase with zinc finger											NS(1)|breast(5)|endometrium(9)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					TACATCTTCTCCTCGTGCTGT	0.378000													8	38					0	0	1	0	0
KIF26A	26153	broad.mit.edu	37	14	104640516	104640516	+	Missense_Mutation	SNP	T	T	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr14:104640516T>A	ENST00000315264.7	+	10	2023	c.1645T>A	c.(1645-1647)Tcc>Acc	p.S549T	KIF26A_ENST00000423312.2_Missense_Mutation_p.S688T			Q9ULI4	KI26A_HUMAN	kinesin family member 26A	688	Kinesin-motor.				blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	21		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		GCTGCGTGAATCCCTGGCCAC	0.687000													3	7					0	0	1	0	0
CYP46A1	10858	broad.mit.edu	37	14	100166436	100166436	+	Silent	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr14:100166436G>C	ENST00000261835.3	+	5	545	c.441G>C	c.(439-441)cgG>cgC	p.R147R	CYP46A1_ENST00000423126.2_Silent_p.R50R	NM_006668.1	NP_006659.1	Q9Y6A2	CP46A_HUMAN	cytochrome P450, family 46, subfamily A, polypeptide 1	147					bile acid biosynthetic process|cholesterol catabolic process|nervous system development|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol 24-hydroxylase activity|electron carrier activity|heme binding|steroid hydroxylase activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|prostate(1)|skin(1)	25		Melanoma(154;0.0866)|all_epithelial(191;0.179)				CCTTCAGCCGGAGGTGAGTGT	0.622000													5	24					0	0	1	0	0
FAM102A	399665	broad.mit.edu	37	9	130742369	130742369	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr9:130742369G>A	ENST00000373095.1	-	1	423	c.48C>T	c.(46-48)ttC>ttT	p.F16F		NM_001035254.2	NP_001030331.1	Q5T9C2	F102A_HUMAN	family with sequence similarity 102, member A	16										breast(1)|cervix(1)|large_intestine(3)|lung(1)|ovary(4)	10						CCTCCAGGGTGAAAGTAGTTT	0.522000													51	107					0	0	1	0	0
ZNF737	100129842	broad.mit.edu	37	19	20727612	20727612	+	Nonsense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:20727612G>C	ENST00000427401.4	-	4	1491	c.1397C>G	c.(1396-1398)tCa>tGa	p.S466*		NM_001159293.1	NP_001152765.1	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	466					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(2)|kidney(1)|lung(7)|ovary(1)|stomach(1)|urinary_tract(1)	13						AGTAAGGTGTGAGGACGAGTT	0.413000													31	54					0	0	1	0	0
PRSS16	10279	broad.mit.edu	37	6	27219016	27219016	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr6:27219016G>A	ENST00000230582.3	+	7	705	c.690G>A	c.(688-690)atG>atA	p.M230I	PRSS16_ENST00000421826.2_Intron	NM_005865.3	NP_005856.1	Q9NQE7	TSSP_HUMAN	protease, serine, 16 (thymus)	230					protein catabolic process|proteolysis	cytoplasmic membrane-bounded vesicle	serine-type peptidase activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	26						GAAGCCTAATGAGCACCGCGA	0.672000													29	28					0	0	1	0	0
ZNF491	126069	broad.mit.edu	37	19	11916930	11916930	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:11916930G>C	ENST00000323169.5	+	3	493	c.162G>C	c.(160-162)agG>agC	p.R54S	ZNF491_ENST00000492230.1_Intron	NM_152356.3	NP_689569.2	Q8N8L2	ZN491_HUMAN	zinc finger protein 491	54					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(14)|lung(6)|ovary(2)|skin(1)	26						CCTTTAATAGGAACATCAGAA	0.393000													16	31					0	0	1	0	0
WDR72	256764	broad.mit.edu	37	15	54003115	54003115	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr15:54003115C>T	ENST00000396328.1	-	9	1132	c.893G>A	c.(892-894)aGa>aAa	p.R298K	WDR72_ENST00000559418.1_Missense_Mutation_p.R310K|WDR72_ENST00000557913.1_Missense_Mutation_p.R297K|WDR72_ENST00000360509.5_Missense_Mutation_p.R298K	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	298										NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		TTTAAGCACTCTTCCATCAGC	0.388000													26	30					0	0	1	0	0
SMC3	9126	broad.mit.edu	37	10	112349666	112349666	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr10:112349666G>A	ENST00000361804.4	+	15	1552	c.1426G>A	c.(1426-1428)Gag>Aag	p.E476K		NM_005445.3	NP_005436.1	Q9UQE7	SMC3_HUMAN	structural maintenance of chromosomes 3	476					cell division|DNA mediated transformation|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic spindle organization|negative regulation of DNA endoreduplication|signal transduction|sister chromatid cohesion	basement membrane|chromatin|chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nuclear matrix|nucleoplasm|spindle pole	ATP binding|dynein binding|microtubule motor activity|protein heterodimerization activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(5)|lung(13)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.00206)|all cancers(201;0.0227)|BRCA - Breast invasive adenocarcinoma(275;0.127)		GTGGAGAGAAGAGAATGCAGA	0.358000													22	41					0	0	1	0	0
MEFV	4210	broad.mit.edu	37	16	3294272	3294272	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr16:3294272C>T	ENST00000219596.1	-	8	1780	c.1741G>A	c.(1741-1743)Gaa>Aaa	p.E581K	MEFV_ENST00000541159.1_Missense_Mutation_p.E370K|MEFV_ENST00000339854.4_Missense_Mutation_p.E401K|MEFV_ENST00000536379.1_Missense_Mutation_p.E370K	NM_000243.2	NP_000234.1	O15553	MEFV_HUMAN	Mediterranean fever	581	B30.2/SPRY.				inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			NS(2)|biliary_tract(1)|breast(5)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(3)|prostate(1)|skin(6)	50					Colchicine(DB01394)	ATTTCCATTTCTGAACGCAGG	0.522000													24	26					0	0	1	0	0
DBN1	1627	broad.mit.edu	37	5	176895189	176895189	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr5:176895189C>G	ENST00000292385.5	-	4	790	c.181G>C	c.(181-183)Gag>Cag	p.E61Q	DBN1_ENST00000393565.1_Missense_Mutation_p.E59Q|DBN1_ENST00000309007.5_Missense_Mutation_p.E59Q	NM_080881.2	NP_543157	Q16643	DREB_HUMAN	drebrin 1	59	ADF-H.				actin filament organization|regulation of dendrite development|regulation of neuronal synaptic plasticity	actomyosin|cytoplasm|dendrite	actin binding|profilin binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(12)|ovary(1)|skin(2)	25	all_cancers(89;2.17e-05)|Renal(175;0.000269)|Lung NSC(126;0.0014)|all_lung(126;0.0025)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTCTGGTTCTCAAAGTGTCCC	0.552000													107	118					0	0	1	0	0
VIPR2	7434	broad.mit.edu	37	7	158827298	158827298	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr7:158827298G>A	ENST00000262178.2	-	9	1038	c.853C>T	c.(853-855)Cga>Tga	p.R285*	VIPR2_ENST00000377633.3_Nonsense_Mutation_p.R269*|VIPR2_ENST00000402066.1_Nonsense_Mutation_p.R426*	NM_003382.4	NP_003373.2	P41587	VIPR2_HUMAN	vasoactive intestinal peptide receptor 2	285					cell-cell signaling	integral to plasma membrane				central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|pancreas(1)|skin(1)|stomach(1)	22	Ovarian(565;0.152)	all_cancers(7;1.13e-11)|all_epithelial(9;0.000545)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00231)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)|STAD - Stomach adenocarcinoma(7;0.18)		ATCGGTATTCGTATGACCCAC	0.478000													18	47					0	0	1	0	0
AIMP1	9255	broad.mit.edu	37	4	107268795	107268795	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr4:107268795G>A	ENST00000394701.4	+	7	998	c.957G>A	c.(955-957)gtG>gtA	p.V319V	AIMP1_ENST00000442366.1_Silent_p.V295V|AIMP1_ENST00000358008.3_Silent_p.V295V	NM_001142416.1	NP_001135888.1	Q12904	AIMP1_HUMAN	aminoacyl tRNA synthetase complex-interacting multifunctional protein 1	295					angiogenesis|apoptosis|cell adhesion|cell-cell signaling|chemotaxis|glucose metabolic process|inflammatory response|leukocyte migration|negative regulation of endothelial cell proliferation|signal transduction|tRNA aminoacylation for protein translation	aminoacyl-tRNA synthetase multienzyme complex|cytosol|endoplasmic reticulum|extracellular space|Golgi apparatus|nucleus|transport vesicle	cell surface binding|cytokine activity|protein homodimerization activity|tRNA binding			breast(1)|endometrium(2)|kidney(1)|lung(5)|skin(1)|urinary_tract(1)	11						CCTTTGAGGTGAAAGGGAAGG	0.413000													4	44					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179432361	179432361	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:179432361C>G	ENST00000589042.1	-	326	78722	c.78498G>C	c.(78496-78498)aaG>aaC	p.K26166N	TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.K23598N|TTN_ENST00000359218.5_Missense_Mutation_p.K17226N|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.K17293N|TTN_ENST00000591111.1_Missense_Mutation_p.K24525N|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.K17101N|TTN-AS1_ENST00000419746.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	24525	Fibronectin type-III 90.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGCTGCATTCTTTGCAATGA	0.388000													16	44					0	0	1	0	0
RASA3	22821	broad.mit.edu	37	13	114758015	114758015	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr13:114758015C>T	ENST00000334062.7	-	22	2312	c.2191G>A	c.(2191-2193)Gag>Aag	p.E731K	RASA3_ENST00000389544.4_Missense_Mutation_p.E699K	NM_007368.2	NP_031394.2	Q14644	RASA3_HUMAN	RAS p21 protein activator 3	731					intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	calcium-release channel activity|metal ion binding|Ras GTPase activator activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(20)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	47	Lung NSC(43;0.00814)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.016)|all_epithelial(44;0.00577)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.188)	BRCA - Breast invasive adenocarcinoma(86;0.128)			TAGATACGCTCCGTCTCACGG	0.527000													15	39					0	0	1	0	0
NTSR2	23620	broad.mit.edu	37	2	11802346	11802346	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:11802346G>A	ENST00000306928.5	-	2	679	c.645C>T	c.(643-645)ttC>ttT	p.F215F		NM_012344.3	NP_036476	O95665	NTR2_HUMAN	neurotensin receptor 2	215					sensory perception	integral to plasma membrane				breast(1)|large_intestine(7)|lung(7)|prostate(1)|urinary_tract(1)	17	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.129)|OV - Ovarian serous cystadenocarcinoma(76;0.24)	Levocabastine(DB01106)	AGGGGAGCACGAAGGACACCA	0.642000													8	141					0	0	1	0	0
ULK4	54986	broad.mit.edu	37	3	41746766	41746766	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr3:41746766G>A	ENST00000301831.4	-	26	3128	c.2666C>T	c.(2665-2667)aCg>aTg	p.T889M		NM_017886.2	NP_060356.2	Q96C45	ULK4_HUMAN	unc-51 like kinase 4	889							ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|large_intestine(6)|lung(7)|prostate(5)|skin(1)	22				KIRC - Kidney renal clear cell carcinoma(284;0.214)		ATCTATGTTCGTTTCTCCTGA	0.294000													40	10					0	0	1	0	0
CCDC18	343099	broad.mit.edu	37	1	93680450	93680450	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:93680450G>C	ENST00000343253.7	+	12	2145	c.1643G>C	c.(1642-1644)aGa>aCa	p.R548T	CCDC18_ENST00000557479.1_Missense_Mutation_p.R667T|CCDC18_ENST00000401026.3_Missense_Mutation_p.R549T|CCDC18_ENST00000338949.4_Missense_Mutation_p.R348T|CCDC18_ENST00000334652.5_5'UTR			Q5T9S5	CCD18_HUMAN	coiled-coil domain containing 18	548										breast(5)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	42		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		ATGGCTCACAGAACTAGTCAG	0.383000													8	14					0	0	1	0	0
NRDE2	55051	broad.mit.edu	37	14	90778760	90778760	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr14:90778760G>C	ENST00000354366.3	-	4	767	c.535C>G	c.(535-537)Ctc>Gtc	p.L179V	NRDE2_ENST00000357904.3_5'UTR	NM_017970.3	NP_060440.2			NRDE-2, necessary for RNA interference, domain containing																		CCTCGGTAGAGAGACTTGTAC	0.478000													31	82					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34208906	34208906	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:34208906C>T	ENST00000373381.4	-	14	2324	c.2148G>A	c.(2146-2148)aaG>aaA	p.K716K		NM_001281956.1|NM_052896.3	NP_001268885.1|NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	676	Sushi 4.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TGAAGCCCCTCTTCCCTGTGG	0.582000													5	20					0	0	1	0	0
SERPINF1	5176	broad.mit.edu	37	17	1675193	1675193	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:1675193C>T	ENST00000254722.4	+	5	630	c.467C>T	c.(466-468)gCa>gTa	p.A156V	SERPINF1_ENST00000571870.1_3'UTR	NM_002615.5	NP_002606.3	P36955	PEDF_HUMAN	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1	156					cell proliferation|negative regulation of angiogenesis|positive regulation of neurogenesis|regulation of proteolysis	extracellular space|melanosome	serine-type endopeptidase inhibitor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(2)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	16						AGCTTTGTGGCACCTCTGGAA	0.557000													9	19					0	0	1	0	0
BECN1	8678	broad.mit.edu	37	17	40963765	40963765	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:40963765C>G	ENST00000361523.4	-	11	1224	c.1092G>C	c.(1090-1092)aaG>aaC	p.K364N	BECN1_ENST00000438274.3_Intron|BECN1_ENST00000590099.1_Missense_Mutation_p.K364N	NM_003766.3	NP_003757.1	Q14457	BECN1_HUMAN	beclin 1, autophagy related	364					anti-apoptosis|cell cycle|cellular defense response|cytokinesis|response to virus	membrane	protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|skin(1)	13		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0745)		CATGGTCAAACTTGTTGTCCC	0.493000													29	64					0	0	1	0	0
TTC40	54777	broad.mit.edu	37	10	134750515	134750515	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr10:134750515C>G	ENST00000368586.5	-	7	805	c.705G>C	c.(703-705)aaG>aaC	p.K235N	TTC40_ENST00000368585.3_Missense_Mutation_p.K235N|TTC40_ENST00000368582.2_Missense_Mutation_p.K235N	NM_001200049.2	NP_001186978.2	Q8IYW2	CJ092_HUMAN	tetratricopeptide repeat domain 40	0										breast(1)|endometrium(5)|lung(19)|urinary_tract(3)	28						TGGAATTTTTCTTTTCTTCCT	0.378000													4	13					0	0	1	0	0
PCNX	22990	broad.mit.edu	37	14	71445358	71445358	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr14:71445358C>T	ENST00000304743.2	+	6	2750	c.2304C>T	c.(2302-2304)gtC>gtT	p.V768V	PCNX_ENST00000439984.3_Silent_p.V768V|PCNX_ENST00000238570.5_Silent_p.V768V	NM_014982.2	NP_055797.2	Q96RV3	PCX1_HUMAN	pecanex homolog (Drosophila)	768						integral to membrane				NS(2)|biliary_tract(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(14)|liver(2)|lung(40)|ovary(1)|prostate(7)|skin(2)|urinary_tract(1)	87			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		AAGATGCAGTCAGTGGAGGTA	0.393000													35	45					0	0	1	0	0
KCNIP1	30820	broad.mit.edu	37	5	170145787	170145787	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr5:170145787G>A	ENST00000328939.4	+	2	624	c.87G>A	c.(85-87)atG>atA	p.M29I	KCNIP1_ENST00000411494.1_Missense_Mutation_p.M40I|KCNIP1_ENST00000520740.1_Start_Codon_SNP_p.M1I|KCNIP1_ENST00000377360.4_Missense_Mutation_p.M38I|KCNIP1_ENST00000434108.1_Missense_Mutation_p.M29I|KCNIP1_ENST00000390656.4_Missense_Mutation_p.M29I	NM_001034837.1|NM_014592.2	NP_001030009.1|NP_055407.1	Q9NZI2	KCIP1_HUMAN	Kv channel interacting protein 1	40					detection of calcium ion|signal transduction|synaptic transmission	plasma membrane	potassium channel activity|voltage-gated ion channel activity			autonomic_ganglia(1)|large_intestine(7)|lung(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	18	Renal(175;0.000159)|Lung NSC(126;0.0191)|all_lung(126;0.0297)	Medulloblastoma(196;0.0109)|all_neural(177;0.0177)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGCTGGAGATGACCATGGTTT	0.512000													13	23					0	0	1	0	0
AGPAT3	56894	broad.mit.edu	37	21	45387862	45387862	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr21:45387862G>C	ENST00000398063.2	+	3	706	c.214G>C	c.(214-216)Gag>Cag	p.E72Q	AGPAT3_ENST00000546158.1_Missense_Mutation_p.E72Q|AGPAT3_ENST00000291572.8_Missense_Mutation_p.E72Q|AGPAT3_ENST00000398058.1_Missense_Mutation_p.E72Q|AGPAT3_ENST00000479117.1_3'UTR|AGPAT3_ENST00000327505.2_Missense_Mutation_p.E72Q|AGPAT3_ENST00000398061.1_Missense_Mutation_p.E72Q	NM_001037553.1	NP_001032642.1	Q9NRZ7	PLCC_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 3	72					phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			large_intestine(4)|lung(5)|ovary(1)|prostate(1)	11				STAD - Stomach adenocarcinoma(101;0.18)|Colorectal(79;0.24)		GTCCTGCACGGAGTGTACACT	0.612000													8	26					0	0	1	0	0
HIST4H4	121504	broad.mit.edu	37	12	14923749	14923749	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr12:14923749C>T	ENST00000539745.1	-	1	316	c.270G>A	c.(268-270)gcG>gcA	p.A90A		NM_175054.2	NP_778224.1	P62805	H4_HUMAN	histone cluster 4, H4	90					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)	6						GGCGTTTCAGCGCGTACACCA	0.582000											OREG0021698	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	52	46					0	0	1	0	0
ZFP57	346171	broad.mit.edu	37	6	29640988	29640988	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr6:29640988G>A	ENST00000376883.1	-	6	1251	c.840C>T	c.(838-840)acC>acT	p.T280T	ZFP57_ENST00000376881.3_Silent_p.T280T|ZFP57_ENST00000488757.1_Silent_p.T300T			Q9NU63	ZFP57_HUMAN	ZFP57 zinc finger protein	216					DNA methylation involved in embryo development|regulation of gene expression by genetic imprinting|transcription, DNA-dependent		DNA binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(16)|ovary(4)|skin(4)|urinary_tract(5)	44						ATTCAGCCTGGGTGCCTGGAA	0.557000													103	23					0	0	1	0	0
ASB4	51666	broad.mit.edu	37	7	95165794	95165794	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr7:95165794G>A	ENST00000325885.5	+	4	1095	c.1024G>A	c.(1024-1026)Gtc>Atc	p.V342I		NM_016116.2	NP_057200.1	Q9Y574	ASB4_HUMAN	ankyrin repeat and SOCS box containing 4	342					intracellular signal transduction					central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(8)|pancreas(1)|prostate(1)|skin(2)	20	all_cancers(62;2.27e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.218)|all_lung(186;0.246)		STAD - Stomach adenocarcinoma(171;0.0151)			TGAAGTTGTAGTCAATGCCTA	0.408000													13	43					0	0	1	0	0
GPC6	10082	broad.mit.edu	37	13	94958333	94958333	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr13:94958333G>C	ENST00000377047.4	+	6	1723	c.1108G>C	c.(1108-1110)Gag>Cag	p.E370Q		NM_005708.3	NP_005699.1	Q9Y625	GPC6_HUMAN	glypican 6	370						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	38	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;5.48e-07)|all_epithelial(2;5.69e-08)|all_lung(2;2.19e-05)|Lung NSC(4;6.09e-05)|Breast(118;0.0395)|Renal(2;0.0568)|Hepatocellular(115;0.217)				CTACAATCCTGAGGAAAGACC	0.502000													19	34					0	0	1	0	0
SPTBN1	6711	broad.mit.edu	37	2	54895611	54895611	+	Missense_Mutation	SNP	G	G	C	rs150630405	byFrequency	TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:54895611G>C	ENST00000356805.4	+	36	7281	c.7000G>C	c.(7000-7002)Gtc>Ctc	p.V2334L		NM_003128.2	NP_003119.2	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1	2334					actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			NS(1)|breast(8)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(27)|ovary(4)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	82			Lung(47;0.24)			CACCAGCGTCGTCACCATCAC	0.567000													24	28					0	0	1	0	0
FGF8	2253	broad.mit.edu	37	10	103534601	103534601	+	Silent	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr10:103534601G>C	ENST00000347978.2	-	3	307	c.138C>G	c.(136-138)ctC>ctG	p.L46L	FGF8_ENST00000485728.1_5'UTR|FGF8_ENST00000346714.3_Silent_p.L35L|FGF8_ENST00000320185.2_Silent_p.L75L|FGF8_ENST00000344255.3_Silent_p.L64L	NM_006119.4	NP_006110.1	P55075	FGF8_HUMAN	fibroblast growth factor 8 (androgen-induced)	64					bone development|dopaminergic neuron differentiation|fibroblast growth factor receptor signaling pathway|gastrulation|gonad development|insulin receptor signaling pathway|mesonephros development|metanephros development|negative regulation of cardiac muscle tissue development|neuroepithelial cell differentiation|odontogenesis|positive regulation of cell division|positive regulation of cell proliferation	extracellular region|extracellular space	growth factor activity|type 1 fibroblast growth factor receptor binding|type 2 fibroblast growth factor receptor binding			endometrium(1)|large_intestine(1)|lung(1)|urinary_tract(2)	5		Colorectal(252;0.122)		Epithelial(162;3.94e-09)|all cancers(201;2.13e-07)		GGCGGCGGCTGAGCTGATCCG	0.542000													10	19					0	0	1	0	0
IL6	3569	broad.mit.edu	37	7	22768323	22768323	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr7:22768323G>C	ENST00000404625.1	+	4	681	c.222G>C	c.(220-222)aaG>aaC	p.K74N	IL6_ENST00000258743.5_Missense_Mutation_p.K74N|IL6_ENST00000406575.1_Missense_Mutation_p.K74N|IL6_ENST00000407492.1_5'UTR|IL6_ENST00000401651.1_5'UTR|IL6_ENST00000420258.2_Missense_Mutation_p.K128N|IL6_ENST00000401630.3_Missense_Mutation_p.K51N			P05231	IL6_HUMAN	interleukin 6 (interferon, beta 2)	74					acute-phase response|cellular response to hydrogen peroxide|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|defense response to virus|endocrine pancreas development|glucagon secretion|hepatic immune response|interleukin-6-mediated signaling pathway|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of chemokine biosynthetic process|negative regulation of collagen biosynthetic process|negative regulation of fat cell differentiation|negative regulation of lipid storage|neuron projection development|neutrophil apoptosis|platelet activation|positive regulation of acute inflammatory response|positive regulation of anti-apoptosis|positive regulation of B cell activation|positive regulation of chemokine production|positive regulation of immunoglobulin secretion|positive regulation of interleukin-6 production|positive regulation of osteoblast differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of smooth muscle cell proliferation|positive regulation of T cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of translation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of vascular endothelial growth factor production|response to glucocorticoid stimulus|response to peptidoglycan	extracellular space|interleukin-6 receptor complex	cytokine activity|growth factor activity|interleukin-6 receptor binding			breast(1)|endometrium(2)|large_intestine(4)|lung(1)	8					Arsenic trioxide(DB01169)|Bicalutamide(DB01128)|Ginseng(DB01404)|Simvastatin(DB00641)	CATGTAACAAGAGTAACATGT	0.428000													5	59					0	0	1	0	0
MTF1	4520	broad.mit.edu	37	1	38289456	38289456	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:38289456G>A	ENST00000373036.4	-	8	1237	c.1097C>T	c.(1096-1098)tCa>tTa	p.S366L		NM_005955.2	NP_005946.2	Q14872	MTF1_HUMAN	metal-regulatory transcription factor 1	366						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			endometrium(3)|kidney(5)|large_intestine(6)|liver(1)|lung(12)|ovary(2)|pancreas(1)|prostate(1)	31	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				GATTGCTGGTGAAATTGTGCT	0.438000													18	34					0	0	1	0	0
TET1	80312	broad.mit.edu	37	10	70446167	70446167	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr10:70446167G>A	ENST00000373644.4	+	11	5316	c.5107G>A	c.(5107-5109)Gag>Aag	p.E1703K		NM_030625.2	NP_085128.2	Q8NFU7	TET1_HUMAN	tet methylcytosine dioxygenase 1	1703					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(2)|ovary(5)|prostate(1)|upper_aerodigestive_tract(2)	21						TCCTCAAGATGAGCAGCTCCA	0.453000													22	53					0	0	1	0	0
TRAF3	7187	broad.mit.edu	37	14	103369714	103369714	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr14:103369714G>A	ENST00000560371.1	+	10	1300	c.1083G>A	c.(1081-1083)gtG>gtA	p.V361V	TRAF3_ENST00000539721.1_Silent_p.V278V|TRAF3_ENST00000392745.2_Silent_p.V361V|TRAF3_ENST00000351691.5_Silent_p.V336V|TRAF3_ENST00000347662.4_Silent_p.V336V	NM_003300.3|NM_145725.2	NP_003291.2|NP_663777.1	Q13114	TRAF3_HUMAN	TNF receptor-associated factor 3	361					apoptosis|induction of apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|regulation of defense response to virus|regulation of interferon-beta production|regulation of proteolysis|toll-like receptor signaling pathway|tumor necrosis factor-mediated signaling pathway	CD40 receptor complex|cytosol|endosome|internal side of plasma membrane|mitochondrion	signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(10)|liver(2)|lung(7)|ovary(1)|prostate(2)	30		all_cancers(154;7.87e-06)|all_epithelial(191;0.0024)		Epithelial(152;9.92e-24)|all cancers(159;2.23e-21)|OV - Ovarian serous cystadenocarcinoma(161;7.85e-12)|Colorectal(3;0.0971)		AGAACCGCGTGACCGAGCTGG	0.652000													37	45					0	0	1	0	0
IGF2R	3482	broad.mit.edu	37	6	160500774	160500774	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr6:160500774G>C	ENST00000356956.1	+	38	5789	c.5641G>C	c.(5641-5643)Gaa>Caa	p.E1881Q		NM_000876.2	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor	1881					receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			breast(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(27)|lung(31)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		GCACCAGGATGAAGCGGTCGT	0.458000													29	18					0	0	1	0	0
KLHDC4	54758	broad.mit.edu	37	16	87760397	87760397	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr16:87760397C>T	ENST00000270583.5	-	7	791	c.733G>A	c.(733-735)Gtc>Atc	p.V245I	KLHDC4_ENST00000566349.1_5'UTR|KLHDC4_ENST00000353170.5_Missense_Mutation_p.V188I|KLHDC4_ENST00000347925.5_Missense_Mutation_p.V214I	NM_017566.3	NP_060036.2	Q8TBB5	KLDC4_HUMAN	kelch domain containing 4	245										breast(2)|endometrium(3)|lung(10)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(2)	21				BRCA - Breast invasive adenocarcinoma(80;0.0283)		CCATAGACGACGATGCCGCCC	0.652000													15	30					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152737694	152737694	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr6:152737694C>G	ENST00000367255.5	-	41	6479	c.5878G>C	c.(5878-5880)Gag>Cag	p.E1960Q	SYNE1_ENST00000341594.5_Missense_Mutation_p.E1997Q|SYNE1_ENST00000448038.1_Missense_Mutation_p.E1967Q|SYNE1_ENST00000423061.1_Missense_Mutation_p.E1967Q|SYNE1_ENST00000265368.4_Missense_Mutation_p.E1960Q	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1960					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGGATCCTCTCTACCTCTCCA	0.502000										HNSCC(10;0.0054)			6	95					0	0	1	0	0
COG5	10466	broad.mit.edu	37	7	106938761	106938761	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr7:106938761C>T	ENST00000393603.2	-	12	1503	c.1232G>A	c.(1231-1233)gGa>gAa	p.G411E	COG5_ENST00000347053.3_Missense_Mutation_p.G411E|COG5_ENST00000297135.3_Missense_Mutation_p.G411E	NM_001161520.1	NP_001154992.1	Q9UP83	COG5_HUMAN	component of oligomeric golgi complex 5	411					intra-Golgi vesicle-mediated transport|protein transport	cytosol|Golgi membrane|Golgi transport complex|nucleus	protein binding			breast(3)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(17)|ovary(2)|skin(4)|stomach(1)	40						AGGGTATTCTCCTTCAAATGC	0.323000													11	26					0	0	1	0	0
TRIM23	373	broad.mit.edu	37	5	64892995	64892995	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr5:64892995G>C	ENST00000231524.9	-	8	1563	c.1192C>G	c.(1192-1194)Cac>Gac	p.H398D	TRIM23_ENST00000381018.3_Missense_Mutation_p.H398D|TRIM23_ENST00000274327.7_Missense_Mutation_p.H398D	NM_001656.3	NP_001647.1	P36406	TRI23_HUMAN	tripartite motif containing 23	398	ARF-like.				interspecies interaction between organisms|small GTPase mediated signal transduction	Golgi membrane|lysosomal membrane	enzyme activator activity|GDP binding|GTP binding|GTPase activity|protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(5)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	28		Lung NSC(167;3.24e-06)|Prostate(74;0.0138)|Breast(144;0.0433)|Ovarian(174;0.0545)|Colorectal(97;0.234)		Lung(70;0.00473)		GGTCCAATGTGAACTCGATTA	0.318000													49	57					0	0	1	0	0
RHPN1	114822	broad.mit.edu	37	8	144457813	144457813	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr8:144457813C>T	ENST00000289013.6	+	2	252	c.151C>T	c.(151-153)Cgg>Tgg	p.R51W		NM_052924.2	NP_443156.2	Q8TCX5	RHPN1_HUMAN	rhophilin, Rho GTPase binding protein 1	51					signal transduction	intracellular				endometrium(1)|large_intestine(1)|lung(7)	9	all_cancers(97;7.39e-11)|all_epithelial(106;5.44e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.156)			GCTGCAGATGCGGACGGGCGC	0.672000													24	20					0	0	1	0	0
JAG1	182	broad.mit.edu	37	20	10621880	10621880	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr20:10621880C>G	ENST00000254958.5	-	24	3444	c.2929G>C	c.(2929-2931)Gag>Cag	p.E977Q	JAG1_ENST00000423891.2_Missense_Mutation_p.E818Q	NM_000214.2	NP_000205.1	P78504	JAG1_HUMAN	jagged 1	977					angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|pancreas(1)|urinary_tract(1)	44						CAAATGTGCTCCGTAGTAAGA	0.408000									Alagille Syndrome				4	62					0	0	1	0	0
MICALL2	79778	broad.mit.edu	37	7	1481960	1481960	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr7:1481960G>C	ENST00000297508.7	-	7	1754	c.1579C>G	c.(1579-1581)Cag>Gag	p.Q527E	MICALL2_ENST00000405088.4_Missense_Mutation_p.Q315E	NM_182924.3	NP_891554.1	Q8IY33	MILK2_HUMAN	MICAL-like 2	527						cytoplasm|cytoskeleton	zinc ion binding	p.Q527E(1)		breast(3)|central_nervous_system(1)|endometrium(1)|kidney(2)|lung(8)|ovary(2)|skin(2)	19		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;6.01e-15)		GCGGATGCCTGAGAGGTACTG	0.667000													50	92					0	0	1	0	0
HKDC1	80201	broad.mit.edu	37	10	71008378	71008378	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr10:71008378G>A	ENST00000354624.5	+	10	1597	c.1464G>A	c.(1462-1464)caG>caA	p.Q488Q	HKDC1_ENST00000395086.2_Silent_p.Q488Q|HKDC1_ENST00000488706.1_3'UTR	NM_025130.3	NP_079406	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	488					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(11)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						TGGACGTGCAGGCCAAGATGC	0.667000													9	15					0	0	1	0	0
TUBG1	7283	broad.mit.edu	37	17	40762134	40762134	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:40762134G>C	ENST00000251413.3	+	2	120	c.58G>C	c.(58-60)Gag>Cag	p.E20Q	FAM134C_ENST00000585894.1_Intron	NM_001070.4	NP_001061.2	P23258	TBG1_HUMAN	tubulin, gamma 1	20					G2/M transition of mitotic cell cycle|meiotic spindle organization|protein polymerization	condensed nuclear chromosome|cytosol|gamma-tubulin complex|polar microtubule	GTP binding|GTPase activity|protein binding|structural constituent of cytoskeleton			endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)	12		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.129)		AGTTGGGTTCGAGTTCTGGAA	0.627000													30	59					0	0	1	0	0
DENND2A	27147	broad.mit.edu	37	7	140273705	140273705	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr7:140273705G>A	ENST00000275884.6	-	5	1766	c.1349C>T	c.(1348-1350)tCc>tTc	p.S450F	DENND2A_ENST00000496613.1_Missense_Mutation_p.S450F|DENND2A_ENST00000537639.1_Missense_Mutation_p.S450F|DENND2A_ENST00000492720.1_Missense_Mutation_p.S450F			Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	450										breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(22)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49	Melanoma(164;0.00956)					GCTGATTTTGGAAGGGGACCC	0.498000													42	109					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	114185980	114185980	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr8:114185980G>A	ENST00000297405.5	-	4	924	c.680C>T	c.(679-681)tCg>tTg	p.S227L	CSMD3_ENST00000519485.1_5'UTR|CSMD3_ENST00000352409.3_Missense_Mutation_p.S227L|CSMD3_ENST00000455883.2_Missense_Mutation_p.S227L|CSMD3_ENST00000343508.3_Missense_Mutation_p.S187L	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	227	Sushi 1.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						AAAATCCCACGAAGCTGTATT	0.433000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			41	138					0	0	1	0	0
CLEC4A	50856	broad.mit.edu	37	12	8290794	8290794	+	Missense_Mutation	SNP	C	C	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr12:8290794C>A	ENST00000229332.5	+	6	872	c.625C>A	c.(625-627)Cgt>Agt	p.R209S	CLEC4A_ENST00000345999.3_Missense_Mutation_p.R137S|CLEC4A_ENST00000352620.3_Missense_Mutation_p.R176S|CLEC4A_ENST00000360500.3_Missense_Mutation_p.R170S	NM_016184.3|NM_194447.2|NM_194450.2	NP_057268.1|NP_919429.2|NP_919432.1	Q9UMR7	CLC4A_HUMAN	C-type lectin domain family 4, member A	209	C-type lectin.				cell adhesion|cell surface receptor linked signaling pathway|innate immune response	integral to plasma membrane	sugar binding|transmembrane receptor activity			cervix(1)|endometrium(3)|large_intestine(2)|lung(4)|prostate(1)	11				Kidney(36;0.0915)		GCTAAATTTTCGTAAATCACC	0.438000													3	88					0.150653	0.151197	1	1	0
C19orf55	148137	broad.mit.edu	37	19	36259446	36259446	+	Nonstop_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:36259446G>C	ENST00000396908.4	+	12	1512	c.1439G>C	c.(1438-1440)tGa>tCa	p.*480S	C19orf55_ENST00000544099.1_3'UTR|C19orf55_ENST00000536037.1_3'UTR	NM_001039887.2	NP_001034976.2	Q2NL68	CS055_HUMAN	chromosome 19 open reading frame 55	0										cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(3)|ovary(2)|prostate(1)	15	all_lung(56;2.87e-07)|Lung NSC(56;4.32e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			AGAAGACTTTGAATTGTACAG	0.498000													29	43					0	0	1	0	0
TRIP12	9320	broad.mit.edu	37	2	230723895	230723895	+	Nonsense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:230723895G>C	ENST00000283943.5	-	3	672	c.494C>G	c.(493-495)tCa>tGa	p.S165*	TRIP12_ENST00000389044.4_Nonsense_Mutation_p.S207*|TRIP12_ENST00000543084.1_Nonsense_Mutation_p.S207*|TRIP12_ENST00000409677.1_Nonsense_Mutation_p.S207*|TRIP12_ENST00000389045.3_Intron	NM_001284214.1|NM_004238.1	NP_001271143.1|NP_004229.1	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	165					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(19)|lung(32)|ovary(5)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		TGCACCAGTTGATTCAGACCC	0.502000													20	11					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39266378	39266378	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr13:39266378G>A	ENST00000280481.7	+	1	5113	c.4897G>A	c.(4897-4899)Gat>Aat	p.D1633N		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	1633					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		TGTTTTTCCTGATACGGTGTT	0.458000													16	42					0	0	1	0	0
AGPAT2	10555	broad.mit.edu	37	9	139571568	139571568	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr9:139571568C>A	ENST00000371696.2	-	3	402	c.337G>T	c.(337-339)Gag>Tag	p.E113*	AGPAT2_ENST00000371694.3_Nonsense_Mutation_p.E113*|AGPAT2_ENST00000538402.1_Nonsense_Mutation_p.E113*	NM_006412.3	NP_006403.2	O15120	PLCB_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 2	113					phosphatidic acid biosynthetic process|positive regulation of cytokine production|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			endometrium(1)|large_intestine(1)|lung(2)|prostate(2)	6	all_cancers(76;0.0893)|all_epithelial(76;0.231)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;9.87e-06)|Epithelial(140;0.000123)		ACGCAGCGCTCCGGAAGGACC	0.647000													9	22					0.00621372	0.00630443	1	1	0
MOGS	7841	broad.mit.edu	37	2	74691751	74691751	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:74691751G>A	ENST00000233616.4	-	2	613	c.451C>T	c.(451-453)Cac>Tac	p.H151Y	MOGS_ENST00000409065.1_Missense_Mutation_p.H151Y|MOGS_ENST00000452063.2_Missense_Mutation_p.H45Y|MOGS_ENST00000535045.1_Intron|MOGS_ENST00000462443.1_Intron	NM_006302.2	NP_006293.2	Q13724	MOGS_HUMAN	mannosyl-oligosaccharide glucosidase	151					oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|membrane fraction	mannosyl-oligosaccharide glucosidase activity			cervix(1)|endometrium(6)|large_intestine(3)|lung(10)|prostate(1)|urinary_tract(2)	23						AGGCCGTCGTGGAACTCCCAG	0.652000													33	55					0	0	1	0	0
CLEC16A	23274	broad.mit.edu	37	16	11076791	11076791	+	Silent	SNP	G	G	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr16:11076791G>T	ENST00000409790.1	+	10	1244	c.1014G>T	c.(1012-1014)ctG>ctT	p.L338L	CLEC16A_ENST00000409552.3_Silent_p.L336L	NM_015226.2	NP_056041.1	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	338										breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						AAGTCATTCTGAATGGTGATC	0.428000													10	39					4.36969e-10	4.67221e-10	1	1	0
SLC43A3	29015	broad.mit.edu	37	11	57188794	57188794	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr11:57188794G>A	ENST00000395123.2	-	6	718	c.414C>T	c.(412-414)atC>atT	p.I138I	SLC43A3_ENST00000395124.1_Silent_p.I138I|SLC43A3_ENST00000528098.1_5'UTR|SLC43A3_ENST00000533524.1_Silent_p.I151I|SLC43A3_ENST00000529554.1_Silent_p.I138I|SLC43A3_ENST00000352187.1_Silent_p.I138I	NM_001278201.1|NM_014096.2	NP_001265130.1|NP_054815.2	Q8NBI5	S43A3_HUMAN	solute carrier family 43, member 3	138					transmembrane transport	integral to membrane		p.I138I(1)		central_nervous_system(1)|endometrium(1)|large_intestine(10)|lung(4)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	27						TGAGAAACAGGATTCCCCCAA	0.562000													16	24					0	0	1	0	0
TRIM9	114088	broad.mit.edu	37	14	51561204	51561204	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr14:51561204C>T	ENST00000298355.3	-	1	1575	c.454G>A	c.(454-456)Gaa>Aaa	p.E152K	TRIM9_ENST00000360392.4_Missense_Mutation_p.E152K|TRIM9_ENST00000338969.5_Missense_Mutation_p.E152K	NM_015163.5	NP_055978.4	Q9C026	TRIM9_HUMAN	tripartite motif containing 9	152					proteasomal ubiquitin-dependent protein catabolic process	cell junction|cytoskeleton|dendrite|synaptic vesicle	protein homodimerization activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_epithelial(31;0.00418)|Breast(41;0.148)					ATTACCCCTTCCAGTACGCGA	0.642000													4	13					0	0	1	0	0
TJP3	27134	broad.mit.edu	37	19	3735874	3735874	+	Silent	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:3735874C>G	ENST00000541714.2	+	10	1530	c.1068C>G	c.(1066-1068)ccC>ccG	p.P356P	TJP3_ENST00000587686.1_Silent_p.P375P|TJP3_ENST00000589378.1_Silent_p.P365P|TJP3_ENST00000382008.3_Silent_p.P370P|TJP3_ENST00000539908.2_Silent_p.P320P|TJP3_ENST00000262968.9_Silent_p.P389P	NM_001267560.1	NP_001254489.1	O95049	ZO3_HUMAN	tight junction protein 3	370						tight junction	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	26				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0118)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGAGTTGCCCAGGGAAAGCA	0.512000													40	92					0	0	1	0	0
ANKRD13B	124930	broad.mit.edu	37	17	27935029	27935029	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:27935029G>A	ENST00000394859.3	+	3	430	c.276G>A	c.(274-276)cgG>cgA	p.R92R	RP11-68I3.2_ENST00000581474.1_RNA	NM_152345.4	NP_689558.4	Q86YJ7	AN13B_HUMAN	ankyrin repeat domain 13B	92										cervix(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|skin(2)	16						TGAGTACCCGGGACCTGGAGC	0.667000													11	27					0	0	1	0	0
VEPH1	79674	broad.mit.edu	37	3	157082155	157082155	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr3:157082155G>C	ENST00000362010.2	-	8	1581	c.1274C>G	c.(1273-1275)tCt>tGt	p.S425C	VEPH1_ENST00000392833.2_Missense_Mutation_p.S425C|VEPH1_ENST00000543418.1_Missense_Mutation_p.S425C|RP11-550I24.2_ENST00000487238.1_RNA|VEPH1_ENST00000392832.2_Missense_Mutation_p.S425C	NM_001167912.1	NP_001161384.1	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain-containing 1	425						plasma membrane				autonomic_ganglia(1)|breast(5)|cervix(1)|kidney(3)|large_intestine(9)|lung(22)|ovary(1)|pancreas(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	48			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			TCTTCTGATAGAGCCAGGGGT	0.348000													10	42					0	0	1	0	0
LILRA3	11026	broad.mit.edu	37	19	54803053	54803053	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:54803053C>T	ENST00000391745.1	-	8	991	c.675G>A	c.(673-675)tgG>tgA	p.W225*	LILRA3_ENST00000391744.3_Intron|LILRA3_ENST00000251390.3_Nonsense_Mutation_p.W208*					leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3											NS(3)|breast(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TGGGTAGAGACCACACATAGG	0.617000													30	27					0	0	1	0	0
CLCNKB	1188	broad.mit.edu	37	1	16375654	16375654	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:16375654C>G	ENST00000375679.4	+	8	806	c.695C>G	c.(694-696)tCt>tGt	p.S232C	CLCNKB_ENST00000375667.3_Missense_Mutation_p.S63C	NM_000085.4	NP_000076.2			chloride channel, voltage-sensitive Kb											breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|prostate(1)|skin(6)|stomach(2)|urinary_tract(1)	21		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		TCCCACTTCTCTGTCTGGGAT	0.637000													27	66					0	0	1	0	0
BACH2	60468	broad.mit.edu	37	6	90647890	90647890	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr6:90647890C>T	ENST00000257749.4	-	8	2723	c.2016G>A	c.(2014-2016)caG>caA	p.Q672Q	BACH2_ENST00000343122.3_Silent_p.Q672Q|BACH2_ENST00000537989.1_Silent_p.Q672Q	NM_021813.2	NP_068585.1	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper transcription factor 2	672						nucleus	protein dimerization activity|sequence-specific DNA binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(18)|ovary(5)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	45		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		ATTCTAAATTCTGAATACAGT	0.458000													58	19					0	0	1	0	0
LYG2	254773	broad.mit.edu	37	2	99861855	99861855	+	Missense_Mutation	SNP	A	A	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:99861855A>T	ENST00000409679.1	-	4	395	c.251T>A	c.(250-252)aTc>aAc	p.I84N	LYG2_ENST00000423800.1_Missense_Mutation_p.I84N|LYG2_ENST00000409238.1_Missense_Mutation_p.I84N|LYG2_ENST00000333017.2_Missense_Mutation_p.I84N			Q86SG7	LYG2_HUMAN	lysozyme G-like 2	84					cell wall macromolecule catabolic process|peptidoglycan catabolic process	extracellular region	lysozyme activity	p.I84T(1)		large_intestine(3)|lung(4)|ovary(1)|prostate(2)|skin(1)|stomach(1)	12						GACTTCTTTGATCAGAGTCTG	0.512000													14	44					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77656085	77656085	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr13:77656085G>A	ENST00000407578.2	-	64	11346	c.11080C>T	c.(11080-11082)Cat>Tat	p.H3694Y	MYCBP2_ENST00000357337.6_Missense_Mutation_p.H3656Y|MYCBP2-AS1_ENST00000450627.2_RNA|MYCBP2-AS1_ENST00000448470.2_RNA|MYCBP2-AS1_ENST00000593933.1_RNA|MYCBP2-AS1_ENST00000422231.2_RNA|MYCBP2_ENST00000544440.2_Missense_Mutation_p.H3656Y	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	3656	DOC.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TTGCTCTGATGAAGGAACTGG	0.363000													23	31					0	0	1	0	0
MSN	4478	broad.mit.edu	37	X	64959692	64959692	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chrX:64959692G>A	ENST00000360270.5	+	13	1843	c.1671G>A	c.(1669-1671)aaG>aaA	p.K557K		NM_002444.2	NP_002435.1	P26038	MOES_HUMAN	moesin	557					leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking	apical plasma membrane|cytoskeleton|extrinsic to membrane|microvillus membrane|nucleolus	cell adhesion molecule binding|receptor binding|structural constituent of cytoskeleton		MSN/ALK(6)	breast(4)|central_nervous_system(3)|endometrium(7)|kidney(5)|large_intestine(6)|lung(11)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	43						ACAAATACAAGACCCTGCGCC	0.547000			T	ALK	ALCL								43	58					0	0	1	0	0
NF1	4763	broad.mit.edu	37	17	29557904	29557904	+	Nonsense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:29557904C>G	ENST00000358273.4	+	24	3541	c.3158C>G	c.(3157-3159)tCa>tGa	p.S1053*	NF1_ENST00000356175.3_Nonsense_Mutation_p.S1053*	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	1053					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(4)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		ATGGGAACATCAAACCAAGCA	0.358000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			4	12					0	0	1	0	0
PAN2	9924	broad.mit.edu	37	12	56720165	56720165	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr12:56720165G>C	ENST00000425394.2	-	8	1667	c.1291C>G	c.(1291-1293)Ctg>Gtg	p.L431V	PAN2_ENST00000440411.3_Missense_Mutation_p.L431V|PAN2_ENST00000548043.1_Missense_Mutation_p.L431V|PAN2_ENST00000257931.5_Missense_Mutation_p.L431V	NM_001127460.2	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)	431					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	41						ATGGTGCGCAGAATCTCTGCA	0.572000													4	17					0	0	1	0	0
MAGEA6	4105	broad.mit.edu	37	X	151870055	151870055	+	Missense_Mutation	SNP	T	T	C	rs140963484	byFrequency	TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chrX:151870055T>C	ENST00000329342.5	+	3	970	c.745T>C	c.(745-747)Tat>Cat	p.Y249H		NM_005363.2	NP_005354.1	P43360	MAGA6_HUMAN	melanoma antigen family A, 6	249	MAGE.						protein binding			breast(1)|endometrium(3)|large_intestine(3)|lung(16)|prostate(3)|skin(1)|urinary_tract(1)	28	Acute lymphoblastic leukemia(192;6.56e-05)					GCTCACCCAATATTTCGTGCA	0.547000													21	89					0	0	1	0	0
PCDHB8	56128	broad.mit.edu	37	5	140558309	140558309	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr5:140558309G>A	ENST00000239444.2	+	1	939	c.694G>A	c.(694-696)Gaa>Aaa	p.E232K		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		232	Cadherin 2.		E -> G (in dbSNP:rs17096954).		homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGTCTACATTGAAGTTGTCGA	0.507000													35	29					0	0	1	0	0
CST11	140880	broad.mit.edu	37	20	23433219	23433219	+	Splice_Site	SNP	A	A	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr20:23433219A>G	ENST00000377009.3	-	1	262		c.e1+1		CST11_ENST00000377007.3_Splice_Site	NM_130794.1	NP_570612.1	Q9H112	CST11_HUMAN	cystatin 11						defense response to bacterium	cytoplasm|nucleus	cysteine-type endopeptidase inhibitor activity			kidney(2)|large_intestine(1)|lung(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	14	Colorectal(13;0.0431)|Lung NSC(19;0.235)					TCATACACTCACCTGCCTCTG	0.527000													45	77					0	0	1	0	0
HTT	3064	broad.mit.edu	37	4	3142363	3142363	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr4:3142363C>G	ENST00000355072.5	+	22	3070	c.2925C>G	c.(2923-2925)ttC>ttG	p.F975L		NM_002111.6	NP_002102	P42858	HD_HUMAN	huntingtin	975					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		CATCTCATTTCTCCGTCAGCA	0.473000													3	62					0	0	1	0	0
SEMG1	6406	broad.mit.edu	37	20	43837052	43837052	+	Missense_Mutation	SNP	C	C	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr20:43837052C>A	ENST00000372781.3	+	2	1171	c.1114C>A	c.(1114-1116)Cgc>Agc	p.R372S	SEMG1_ENST00000244069.6_Missense_Mutation_p.R312S	NM_003007.3	NP_002998.1			semenogelin I											cervix(1)|endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(12)|prostate(1)|skin(6)|stomach(2)|urinary_tract(1)	32		Myeloproliferative disorder(115;0.0122)				TGTATCCCAACGCAGTATTTA	0.418000													4	58					0.00024832	0.000256628	1	1	0
PIK3CA	5290	broad.mit.edu	37	3	178922324	178922324	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr3:178922324G>A	ENST00000263967.3	+	6	1250	c.1093G>A	c.(1093-1095)Gaa>Aaa	p.E365K		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	365	C2 PI3K-type.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E365K(6)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			CCATGGAGGAGAACCCTTATG	0.343000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			58	62					0	0	1	0	0
SLC7A3	84889	broad.mit.edu	37	X	70148356	70148356	+	Silent	SNP	G	G	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chrX:70148356G>T	ENST00000374299.3	-	4	801	c.657C>A	c.(655-657)ctC>ctA	p.L219L	SLC7A3_ENST00000298085.4_Silent_p.L219L			Q8WY07	CTR3_HUMAN	solute carrier family 7 (cationic amino acid transporter, y+ system), member 3	219					cellular nitrogen compound metabolic process	integral to membrane|plasma membrane				breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|liver(1)|lung(9)|ovary(1)|urinary_tract(1)	31	Renal(35;0.156)				L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	CCTCTTCTGTGAGCTTCCAGT	0.507000													4	7					0.184627	0.184627	1	1	0
SUSD3	203328	broad.mit.edu	37	9	95840160	95840160	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr9:95840160G>A	ENST00000375472.3	+	3	346	c.310G>A	c.(310-312)Gtg>Atg	p.V104M	SUSD3_ENST00000375469.1_Missense_Mutation_p.V91M	NM_145006.2	NP_659443.1	Q96L08	SUSD3_HUMAN	sushi domain containing 3	104						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(2)	13						TGGCTTCAAGGTGGCCGTGAT	0.597000													27	33					0	0	1	0	0
SPATA22	84690	broad.mit.edu	37	17	3352316	3352316	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:3352316G>C	ENST00000573128.1	-	6	940	c.457C>G	c.(457-459)Caa>Gaa	p.Q153E	SPATA22_ENST00000541913.1_Missense_Mutation_p.Q137E|SPATA22_ENST00000268981.5_Missense_Mutation_p.Q153E|SPATA22_ENST00000575375.1_Missense_Mutation_p.Q153E|SPATA22_ENST00000355380.4_Missense_Mutation_p.Q110E|SPATA22_ENST00000397168.3_Missense_Mutation_p.Q153E|SPATA22_ENST00000572969.1_Missense_Mutation_p.Q153E			Q8NHS9	SPT22_HUMAN	spermatogenesis associated 22	153										breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|skin(2)	19						TTTTGTTGTTGAGCTCCCGAA	0.358000													35	83					0	0	1	0	0
CDH1	999	broad.mit.edu	37	16	68863653	68863653	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr16:68863653C>G	ENST00000261769.5	+	15	2583	c.2392C>G	c.(2392-2394)Ctt>Gtt	p.L798V	CDH1_ENST00000562836.1_3'UTR|CDH1_ENST00000422392.2_Missense_Mutation_p.L737V	NM_004360.3	NP_004351.1	P12830	CADH1_HUMAN	cadherin 1, type 1, E-cadherin (epithelial)	798					adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding			NS(6)|biliary_tract(8)|breast(161)|central_nervous_system(4)|endometrium(9)|kidney(4)|large_intestine(13)|lung(13)|oesophagus(3)|ovary(2)|prostate(3)|soft_tissue(2)|stomach(76)|thyroid(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	311		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		CCCCCGGTATCTTCCCCGCCC	0.522000			"""Mis, N, F, S"""		"""lobular breast, gastric"""	gastric			Hereditary Diffuse Gastric Cancer				19	80					0	0	1	0	0
GOLGA6L7P	728310	broad.mit.edu	37	15	29092257	29092257	+	RNA	SNP	C	C	T	rs75388271	by1000genomes	TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr15:29092257C>T	ENST00000569815.1	-	0	258					NR_047567.1																						TCAGGGTTAGCGCCATGATTT	0.547000													4	32					0	0	1	0	0
ZNF761	388561	broad.mit.edu	37	19	53958360	53958360	+	RNA	SNP	C	C	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:53958360C>A	ENST00000454407.1	+	0	1052							Q86XN6	ZN761_HUMAN	zinc finger protein 761						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.S146*(1)		endometrium(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	30				GBM - Glioblastoma multiforme(134;0.00786)		TGGAATTCTTCATTACTCACA	0.373000													31	62					2.46105e-21	2.72579e-21	1	1	0
PDE4DIP	9659	broad.mit.edu	37	1	144879256	144879256	+	Silent	SNP	C	C	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:144879256C>A	ENST00000369359.4	-	30	4640	c.4602G>T	c.(4600-4602)ctG>ctT	p.L1534L	PDE4DIP_ENST00000369356.4_Silent_p.L1398L|PDE4DIP_ENST00000530740.1_Silent_p.L1534L|PDE4DIP_ENST00000524974.1_5'UTR|PDE4DIP_ENST00000313382.9_Silent_p.L1354L|PDE4DIP_ENST00000369354.3_Silent_p.L1398L			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	1398					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CAACAGCTCTCAGCTTCCAGG	0.537000			T	PDGFRB	MPD								19	102					1.00905e-13	1.09576e-13	1	1	0
UBE4A	9354	broad.mit.edu	37	11	118257262	118257262	+	Missense_Mutation	SNP	A	A	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr11:118257262A>G	ENST00000252108.3	+	16	2653	c.2522A>G	c.(2521-2523)cAg>cGg	p.Q841R	UBE4A_ENST00000431736.2_Missense_Mutation_p.Q848R|UBE4A_ENST00000545354.1_Missense_Mutation_p.Q313R	NM_001204077.1|NM_004788.3	NP_001191006.1|NP_004779.2	Q14139	UBE4A_HUMAN	ubiquitination factor E4A	841					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding			autonomic_ganglia(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(7)|liver(2)|lung(14)|ovary(3)|prostate(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	56	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		ATGTTTGGACAGCTGGCACGT	0.468000													48	154					0	0	1	0	0
PDXK	8566	broad.mit.edu	37	21	45152403	45152403	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr21:45152403C>T	ENST00000327574.4	+	2	495	c.145C>T	c.(145-147)Ctc>Ttc	p.L49F	PDXK_ENST00000468090.1_Intron|PDXK_ENST00000476313.1_Intron|PDXK_ENST00000291565.4_Intron|PDXK_ENST00000398081.1_Intron			O00764	PDXK_HUMAN	pyridoxal (pyridoxine, vitamin B6) kinase	109					cell proliferation|pyridoxal 5'-phosphate salvage	cytosol	ATP binding|lithium ion binding|magnesium ion binding|potassium ion binding|protein homodimerization activity|pyridoxal kinase activity|pyridoxal phosphate binding|sodium ion binding|zinc ion binding			endometrium(1)|lung(2)|ovary(1)|urinary_tract(1)	5				Colorectal(79;0.109)|READ - Rectum adenocarcinoma(84;0.161)|STAD - Stomach adenocarcinoma(101;0.18)	Pyridoxal(DB00147)|Pyridoxine(DB00165)	CGACTTCATTCTCGGATACGT	0.458000													34	57					0	0	1	0	0
KLK6	5653	broad.mit.edu	37	19	51470539	51470539	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:51470539C>T	ENST00000376851.3	-	3	522	c.83G>A	c.(82-84)tGc>tAc	p.C28Y	KLK6_ENST00000391808.1_5'UTR|KLK6_ENST00000424910.2_Intron|KLK6_ENST00000310157.2_Missense_Mutation_p.C28Y|KLK6_ENST00000376853.4_Missense_Mutation_p.C28Y|KLK6_ENST00000594641.1_Missense_Mutation_p.C28Y	NM_001012964.1	NP_001012982.1	Q92876	KLK6_HUMAN	kallikrein-related peptidase 6	28	Peptidase S1.				amyloid precursor protein metabolic process|central nervous system development|collagen catabolic process|hormone metabolic process|myelination|positive regulation of G-protein coupled receptor protein signaling pathway|protein autoprocessing|proteolysis|regulation of cell differentiation|tissue regeneration	endoplasmic reticulum|extracellular region|microsome|mitochondrion|nucleolus	protein binding|serine-type endopeptidase activity			endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|skin(4)	13		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00372)|GBM - Glioblastoma multiforme(134;0.00871)		TGTCTTGTCGCAGGGTCCGCC	0.587000													10	25					0	0	1	0	0
IL6R	3570	broad.mit.edu	37	1	154420627	154420627	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:154420627G>A	ENST00000368485.3	+	7	1413	c.976G>A	c.(976-978)Gag>Aag	p.E326K	IL6R_ENST00000507256.1_3'UTR|IL6R_ENST00000344086.4_Missense_Mutation_p.E326K	NM_000565.3	NP_000556.1	P08887	IL6RA_HUMAN	interleukin 6 receptor	326					acute-phase response|ciliary neurotrophic factor-mediated signaling pathway|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|endocrine pancreas development|hepatic immune response|negative regulation of collagen biosynthetic process|negative regulation of interleukin-8 production|positive regulation of activation of Janus kinase activity|positive regulation of anti-apoptosis|positive regulation of chemokine production|positive regulation of interleukin-6 production|positive regulation of leukocyte chemotaxis|positive regulation of MAPKKK cascade|positive regulation of osteoblast differentiation|positive regulation of smooth muscle cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of apoptosis	apical plasma membrane|basolateral plasma membrane|extracellular space|interleukin-6 receptor complex	ciliary neurotrophic factor binding|enzyme binding|protein homodimerization activity		IL6R/ATP8B2(2)	breast(2)|large_intestine(1)|ovary(3)	6	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			AGCTGAGAACGAGGTGTCCAC	0.547000													38	64					0	0	1	0	0
AK1	203	broad.mit.edu	37	9	130630320	130630320	+	Silent	SNP	G	G	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr9:130630320G>A	ENST00000373176.1	-	7	704	c.552C>T	c.(550-552)tcC>tcT	p.S184S	RP11-203J24.9_ENST00000476274.2_RNA|AK1_ENST00000373156.1_Silent_p.S184S|AK1_ENST00000223836.10_Silent_p.S200S	NM_000476.2	NP_000467.1	P00568	KAD1_HUMAN	adenylate kinase 1	184					ATP metabolic process|nucleobase, nucleoside and nucleotide interconversion	cytosol	adenylate kinase activity|ATP binding|protein binding			endometrium(1)|prostate(1)	2						TGCAGACCTGGGAGAAGACAC	0.662000													20	41					0	0	1	0	0
CYP21A1P	1590	broad.mit.edu	37	6	31975500	31975500	+	RNA	SNP	C	C	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr6:31975500C>A	ENST00000342991.6	+	0	1423					NR_040090.1		Q5ST44	Q5ST44_HUMAN									electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen										CCTGGTGCCTCCAGCTCCCGG	0.657000													11	15					6.72482e-11	7.21815e-11	1	1	0
LOC647323	647323	broad.mit.edu	37	3	193712013	193712013	+	RNA	SNP	C	C	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr3:193712013C>A	ENST00000397645.2	-	0	75				RP11-699L21.2_ENST00000426616.1_lincRNA	NR_033944.1																						CTGACATTTTCAGCAACACCC	0.463000													4	3					0.00909568	0.00916159	1	1	0
SPRED3	399473	broad.mit.edu	37	19	38881044	38881044	+	Silent	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:38881044C>T	ENST00000338502.4	+	1	205	c.102C>T	c.(100-102)gtC>gtT	p.V34V	SPRED3_ENST00000586301.1_Silent_p.V34V|SPRED3_ENST00000587564.2_3'UTR|SPRED3_ENST00000587013.1_Intron	NM_001042522.2	NP_001035987.1	Q2MJR0	SPRE3_HUMAN	sprouty-related, EVH1 domain containing 3	34	WH1.				multicellular organismal development					central_nervous_system(2)|large_intestine(1)|lung(5)|skin(1)	9	all_cancers(60;3.4e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			TGTGTCGGGTCCGAGGGGCCA	0.731000													4	8					0	0	1	0	0
MPHOSPH6	10200	broad.mit.edu	37	16	82183009	82183009	+	Splice_Site	SNP	C	C	A			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr16:82183009C>A	ENST00000258169.4	-	4	306		c.e4-1		MPHOSPH6_ENST00000563504.1_Splice_Site	NM_005792.2	NP_005783.2	Q99547	MPH6_HUMAN	M-phase phosphoprotein 6						M phase of mitotic cell cycle|maturation of 5.8S rRNA	cytoplasm|nucleolus	protein binding|RNA binding			endometrium(1)|large_intestine(1)|lung(3)	5						GCATCAATTTCTGAAAAATAC	0.398000													34	35					1.90571e-15	2.08578e-15	1	1	0
DOCK2	1794	broad.mit.edu	37	5	169461533	169461533	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr5:169461533C>T	ENST00000256935.8	+	35	3678	c.3598C>T	c.(3598-3600)Cgc>Tgc	p.R1200C	DOCK2_ENST00000523351.1_3'UTR|DOCK2_ENST00000520908.1_Missense_Mutation_p.R692C|DOCK2_ENST00000540750.1_Missense_Mutation_p.R261C	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1200	DHR-2.|Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding	p.R1200C(1)		NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CAAAGACAACCGCATGAGCTG	0.592000													19	46					0	0	1	0	0
ARHGAP39	80728	broad.mit.edu	37	8	145773342	145773344	+	In_Frame_Del	DEL	CTG	CTG	-	rs77462981		TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr8:145773342_145773344delCTG	ENST00000276826.5	-	4	1327_1329	c.1126_1128delCAG	c.(1126-1128)cagdel	p.Q376del	ARHGAP39_ENST00000540274.1_In_Frame_Del_p.Q376del|ARHGAP39_ENST00000377307.2_In_Frame_Del_p.Q376del			Q9C0H5	RHG39_HUMAN	Rho GTPase activating protein 39	376					axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22						CGGGACACTTCTGCTTGGTGAGC	0.704													9	4	---	---	---	---					
RP11-286N22.10	0	broad.mit.edu	37	11	61265344	61265345	+	RNA	DEL	TG	TG	-			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr11:61265344_61265345delTG	ENST00000534856.1	+	0	240																											TTGGAGAGCCTGTGTGTGTGTG	0.500													2	4	---	---	---	---					
TIGD3	220359	broad.mit.edu	37	11	65124162	65124162	+	Frame_Shift_Del	DEL	C	C	-			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr11:65124162delC	ENST00000309880.5	+	2	1090	c.883delC	c.(883-885)cccfs	p.P295fs		NM_145719.2	NP_663771.1	Q6B0B8	TIGD3_HUMAN	tigger transposable element derived 3	295	DDE.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding			endometrium(3)|large_intestine(1)|lung(9)|prostate(2)|skin(2)	17						CACCACGCCTCCCCTGCCCAG	0.652													24	69	---	---	---	---					
LTBP3	4054	broad.mit.edu	37	11	65315174	65315174	+	Frame_Shift_Del	DEL	C	C	-			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr11:65315174delC	ENST00000301873.5	-	13	2233	c.1965delG	c.(1963-1965)gggfs	p.G655fs	LTBP3_ENST00000536982.1_Frame_Shift_Del_p.G281fs|LTBP3_ENST00000322147.4_Frame_Shift_Del_p.G655fs|LTBP3_ENST00000532932.1_Frame_Shift_Del_p.G85fs	NM_001130144.2	NP_001123616.1	Q9NS15	LTBP3_HUMAN	latent transforming growth factor beta binding protein 3	655	Cys-rich.|EGF-like 4; calcium-binding (Potential).					extracellular region	calcium ion binding|growth factor binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|prostate(2)|upper_aerodigestive_tract(3)	23						CGCACGAGCGCCCCCCGGCGC	0.736													2	4	---	---	---	---					
PRB2	653247	broad.mit.edu	37	12	11546732	11546733	+	In_Frame_Ins	INS	-	-	AGA			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr12:11546732_11546733insAGA	ENST00000389362.4	-	3	314_315	c.279_280insTCT	c.(277-282)ccacct>ccaTCTcct	p.93_94PP>PSP	PRB1_ENST00000546254.1_Intron	NM_006248.3	NP_006239.3			proline-rich protein BstNI subfamily 2											NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(5)|skin(4)|stomach(2)|urinary_tract(1)	37		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			TTTCCTGGAGGTGGGGGACCTT	0.614													9	706	---	---	---	---					
IGHV3-30	28439	broad.mit.edu	37	14	106791039	106791040	+	RNA	INS	-	-	T			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr14:106791039_106791040insT	ENST00000390613.2	-	0	395_396																											GTCCTCAGCTCTCAGGCTGTTC	0.510													100	562	---	---	---	---					
CHRNA3	1136	broad.mit.edu	37	15	78913068	78913070	+	In_Frame_Del	DEL	CAG	CAG	-	rs72025661		TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr15:78913068_78913070delCAG	ENST00000326828.5	-	1	451_453	c.67_69delCTG	c.(67-69)ctgdel	p.L23del	CHRNA3_ENST00000348639.3_In_Frame_Del_p.L23del	NM_000743.4	NP_000734.2	P32297	ACHA3_HUMAN	cholinergic receptor, nicotinic, alpha 3 (neuronal)	23			Missing.		activation of transmembrane receptor protein tyrosine kinase activity|behavioral response to nicotine|locomotory behavior|regulation of acetylcholine secretion|regulation of dendrite morphogenesis|regulation of excitatory postsynaptic membrane potential|regulation of smooth muscle contraction|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|dendrite|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic density|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						gcagcagagacagcagcagcagc	0.768													3	6	---	---	---	---					
DNM1P47	100216544	broad.mit.edu	37	15	102299886	102299887	+	RNA	INS	-	-	G			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr15:102299886_102299887insG	ENST00000561463.1	+	0	7932_7933																											AACCTGTACTCGCGTCGGAACC	0.589													2	4	---	---	---	---					
LINC01229	101928248	broad.mit.edu	37	16	79756932	79756934	+	RNA	DEL	TGG	TGG	-	rs67854673		TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr16:79756932_79756934delTGG	ENST00000561510.1	+	0	361																											atgatggtgatggtggtggtggt	0.567													3	3	---	---	---	---					
WDR81	124997	broad.mit.edu	37	17	1631642	1631642	+	Frame_Shift_Del	DEL	C	C	-			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:1631642delC	ENST00000409644.1	+	1	3389	c.3389delC	c.(3388-3390)gccfs	p.A1130fs	WDR81_ENST00000446363.1_Intron|WDR81_ENST00000309182.5_Frame_Shift_Del_p.A79fs|WDR81_ENST00000419248.1_Intron|RP11-961A15.1_ENST00000576540.1_RNA|WDR81_ENST00000437219.2_Intron	NM_001163809.1	NP_001157281.1	B3KXU1	B3KXU1_HUMAN	WD repeat domain 81	0										cervix(1)|endometrium(1)|kidney(3)|lung(6)|ovary(2)|prostate(2)|skin(1)	16				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		GAGGGGGGTGCCCCCGTGGAC	0.662													37	65	---	---	---	---					
SCRT2	85508	broad.mit.edu	37	20	644846	644847	+	Frame_Shift_Ins	INS	-	-	C			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr20:644846_644847insC	ENST00000246104.6	-	2	969_970	c.392_393insG	c.(391-393)ggcfs	p.G131fs	RP5-850E9.3_ENST00000488788.2_Intron	NM_033129.3	NP_149120.1	Q9NQ03	SCRT2_HUMAN	scratch family zinc finger 2	131					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(1)|liver(1)|ovary(1)	3						cgtctcccgagccccccgcgtc	0.822													2	4	---	---	---	---					
BCL2L1	598	broad.mit.edu	37	20	30309591	30309591	+	Frame_Shift_Del	DEL	A	A	-			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr20:30309591delA	ENST00000307677.4	-	2	841	c.431delT	c.(430-432)ttcfs	p.F144fs	BCL2L1_ENST00000420653.1_Frame_Shift_Del_p.F144fs|BCL2L1_ENST00000376062.2_Frame_Shift_Del_p.F144fs|BCL2L1_ENST00000376055.4_Intron	NM_138578.1	NP_612815.1	Q07817	B2CL1_HUMAN	BCL2-like 1	144					induction of apoptosis by intracellular signals|negative regulation of establishment of protein localization in plasma membrane|negative regulation of survival gene product expression|regulation of mitochondrial membrane permeability|regulation of mitochondrial membrane potential|release of cytochrome c from mitochondria|response to cytokine stimulus	integral to membrane|mitochondrial outer membrane|nuclear membrane	BH3 domain binding|identical protein binding			breast(1)|central_nervous_system(1)|large_intestine(2)|lung(4)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11	all_cancers(5;3.47e-06)|all_epithelial(3;1.83e-06)|Lung NSC(7;2.08e-06)|all_lung(7;3.63e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Epithelial(4;2.97e-06)|all cancers(5;3.21e-05)|OV - Ovarian serous cystadenocarcinoma(3;0.00052)|Colorectal(19;0.0055)|COAD - Colon adenocarcinoma(19;0.0264)			GCCGAAGGAGAAAAAGGCCAC	0.542													7	1557	---	---	---	---					
SYCP2	10388	broad.mit.edu	37	20	58467047	58467047	+	Frame_Shift_Del	DEL	T	T	-			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr20:58467047delT	ENST00000357552.3	-	24	2587	c.2362delA	c.(2362-2364)atgfs	p.M788fs	SYCP2_ENST00000371001.2_Frame_Shift_Del_p.M788fs			Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	788					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding	p.M788fs*1(1)		NS(4)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(14)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			AAGCTCACCATTTTTTTTTGT	0.323													7	72	---	---	---	---					
ZNF185	7739	broad.mit.edu	37	X	152087570	152087572	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chrX:152087570_152087572delGAG	ENST00000535861.1	+	7	523_525	c.475_477delGAG	c.(475-477)gagdel	p.E165del	ZNF185_ENST00000370268.4_In_Frame_Del_p.E165del|ZNF185_ENST00000318529.8_In_Frame_Del_p.E30del|ZNF185_ENST00000370270.2_In_Frame_Del_p.E165del|ZNF185_ENST00000449285.2_In_Frame_Del_p.E165del|ZNF185_ENST00000539731.1_In_Frame_Del_p.E165del|ZNF185_ENST00000324823.6_In_Frame_Del_p.E30del|ZNF185_ENST00000318504.7_In_Frame_Del_p.E165del	NM_001178106.1	NP_001171577.1	O15231	ZN185_HUMAN	zinc finger protein 185 (LIM domain)	165	Poly-Glu.					cytoplasm|cytoskeleton|focal adhesion	zinc ion binding			NS(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(3)	12	Acute lymphoblastic leukemia(192;6.56e-05)					AGGGGACACCgaggaggaggagg	0.596													7	38	---	---	---	---