Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TP53INP2	58476	broad.mit.edu	37	20	33296549	33296549	+	Silent	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr20:33296549C>T	ENST00000374810.3	+	3	395	c.6C>T	c.(4-6)ttC>ttT	p.F2F	NCOA6_ENST00000593786.1_Intron|TP53INP2_ENST00000374809.2_Silent_p.F2F	NM_021202.1	NP_067025.1	Q8IXH6	T53I2_HUMAN	tumor protein p53 inducible nuclear protein 2	2						nucleus				endometrium(1)|urinary_tract(1)	2						CCACCATGTTCCAGCGCCTCT	0.652000													11	10					0	0	0.069234	0	0
KIAA2018	205717	broad.mit.edu	37	3	113376298	113376298	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr3:113376298G>C	ENST00000316407.4	-	7	4641	c.4231C>G	c.(4231-4233)Cct>Gct	p.P1411A	KIAA2018_ENST00000478658.1_Missense_Mutation_p.P1411A|KIAA2018_ENST00000491165.1_Intron	NM_001009899.2	NP_001009899.2	Q68DE3	K2018_HUMAN	KIAA2018	1411					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(30)|ovary(8)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	80						CTCAATGCAGGAGTCACAAAG	0.488000													26	23					0	0	0.099896	0	0
RTTN	25914	broad.mit.edu	37	18	67872392	67872392	+	Missense_Mutation	SNP	A	A	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr18:67872392A>C	ENST00000255674.6	-	2	477	c.191T>G	c.(190-192)gTt>gGt	p.V64G	RTTN_ENST00000437017.1_Missense_Mutation_p.V64G|RTTN_ENST00000454359.1_Missense_Mutation_p.V64G	NM_173630.3	NP_775901.3	Q86VV8	RTTN_HUMAN	rotatin	64							binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(35)|ovary(4)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Esophageal squamous(42;0.129)				CAGGTTCAGAACCTCTTCCTT	0.388000													76	61					0	0	0.139131	0	0
CDH3	1001	broad.mit.edu	37	16	68713791	68713791	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr16:68713791G>C	ENST00000264012.4	+	7	1325	c.781G>C	c.(781-783)Gaa>Caa	p.E261Q	CDH3_ENST00000429102.2_Missense_Mutation_p.E261Q|CDH3_ENST00000581171.1_Missense_Mutation_p.E206Q	NM_001793.4	NP_001784.2	P22223	CADH3_HUMAN	cadherin 3, type 1, P-cadherin (placental)	261	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion|response to stimulus|visual perception	integral to membrane	calcium ion binding	p.?(2)		NS(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(3)|skin(1)|urinary_tract(1)	25		Ovarian(137;0.0564)		OV - Ovarian serous cystadenocarcinoma(108;0.000782)|Epithelial(162;0.0054)|all cancers(182;0.0384)		CCATAGCCAAGAACCAAAGGA	0.547000													62	47					0	0	0.139131	0	0
PELI2	57161	broad.mit.edu	37	14	56755262	56755262	+	Silent	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr14:56755262C>T	ENST00000267460.4	+	4	703	c.417C>T	c.(415-417)ttC>ttT	p.F139F		NM_021255.2	NP_067078.1	Q9HAT8	PELI2_HUMAN	pellino E3 ubiquitin protein ligase family member 2	139					innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of protein phosphorylation|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	protein binding			kidney(6)|large_intestine(3)|lung(11)|ovary(1)|skin(1)	22						TATCCAGGTTCGCCTGCAGGA	0.498000													25	23					0	0	0.083992	0	0
ZWILCH	55055	broad.mit.edu	37	15	66828290	66828290	+	Nonsense_Mutation	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr15:66828290C>G	ENST00000307897.5	+	15	1741	c.1361C>G	c.(1360-1362)tCa>tGa	p.S454*	ZWILCH_ENST00000565627.1_Nonsense_Mutation_p.S340*|ZWILCH_ENST00000535141.2_Nonsense_Mutation_p.S340*|ZWILCH_ENST00000446801.2_Nonsense_Mutation_p.S340*	NM_017975.3	NP_060445.3	Q9H900	ZWILC_HUMAN	zwilch kinetochore protein	454					cell division|mitotic cell cycle checkpoint|mitotic prometaphase	condensed chromosome kinetochore|cytosol	protein binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|liver(1)|lung(6)|ovary(1)	18						ATTGCTCCATCAGTAGATATA	0.333000													27	2					0	0	0.134883	0	0
GTF3C1	2975	broad.mit.edu	37	16	27561125	27561125	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr16:27561125C>G	ENST00000356183.4	-	1	102	c.87G>C	c.(85-87)gaG>gaC	p.E29D	GTF3C1_ENST00000561623.1_Missense_Mutation_p.E29D	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	29						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						GCACTCGCGTCTCCAGCCGGC	0.652000													22	22					0	0	0.083992	0	0
UBE4B	10277	broad.mit.edu	37	1	10166258	10166258	+	Silent	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:10166258C>G	ENST00000343090.6	+	7	888	c.813C>G	c.(811-813)ctC>ctG	p.L271L	UBE4B_ENST00000253251.8_Intron|UBE4B_ENST00000377157.3_Intron	NM_001105562.2	NP_001099032.1	O95155	UBE4B_HUMAN	ubiquitination factor E4B	271					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			NS(3)|breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(14)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	48		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		AATTTAGCCTCTATGAAAGTA	0.448000													56	31					0	0	0.139131	0	0
BAI3	577	broad.mit.edu	37	6	70098718	70098718	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr6:70098718G>C	ENST00000370598.1	+	32	5325	c.4504G>C	c.(4504-4506)Gag>Cag	p.E1502Q	BAI3_ENST00000238918.8_Missense_Mutation_p.E708Q|BAI3_ENST00000546190.1_Missense_Mutation_p.E466Q	NM_001704.2	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1502					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				GAGGCCAGCAGAGTGGGAGAA	0.428000													12	24					0	0	0.119110	0	0
CDH1	999	broad.mit.edu	37	16	68844153	68844153	+	Silent	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr16:68844153G>A	ENST00000261769.5	+	6	932	c.741G>A	c.(739-741)gaG>gaA	p.E247E	CDH1_ENST00000422392.2_Silent_p.E247E|CDH1_ENST00000562836.1_3'UTR	NM_004360.3	NP_004351.1	P12830	CADH1_HUMAN	cadherin 1, type 1, E-cadherin (epithelial)	247	Cadherin 1.				adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding	p.?(4)		NS(6)|biliary_tract(8)|breast(161)|central_nervous_system(4)|endometrium(9)|kidney(4)|large_intestine(13)|lung(13)|oesophagus(3)|ovary(2)|prostate(3)|soft_tissue(2)|stomach(76)|thyroid(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	311		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		ATCCAATGGAGATTTTGATCA	0.478000			"""Mis, N, F, S"""		"""lobular breast, gastric"""	gastric			Hereditary Diffuse Gastric Cancer				66	78					0	0	0.139131	0	0
TTC17	55761	broad.mit.edu	37	11	43471676	43471676	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr11:43471676C>G	ENST00000039989.4	+	20	2845	c.2831C>G	c.(2830-2832)gCa>gGa	p.A944G		NM_018259.5	NP_060729.2	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17	944							binding			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(27)|ovary(5)|prostate(3)|skin(3)	53						CAGCAGCCAGCAATGGAGCCT	0.498000													56	59					0	0	0.139131	0	0
LEPREL2	10536	broad.mit.edu	37	12	6938985	6938985	+	RNA	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr12:6938985C>T	ENST00000251761.8	+	0	531				LEPREL2_ENST00000606935.1_RNA|LEPREL2_ENST00000396725.2_RNA	NM_014262.3	NP_055077.2			leprecan-like 2											breast(1)|cervix(1)|endometrium(2)|lung(6)	10						TGCCCCCCGTCCCAGGGCTCT	0.627000											OREG0021637	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	44	43					0	0	0.111260	0	0
USP13	8975	broad.mit.edu	37	3	179458161	179458161	+	Splice_Site	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr3:179458161G>A	ENST00000263966.3	+	11	1851		c.e11+1		USP13_ENST00000482333.1_Splice_Site|USP13_ENST00000496897.1_Splice_Site	NM_003940.2	NP_003931.2	Q92995	UBP13_HUMAN	ubiquitin specific peptidase 13 (isopeptidase T-3)						ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	46	all_cancers(143;7.79e-15)|Ovarian(172;0.0338)|Breast(254;0.148)		OV - Ovarian serous cystadenocarcinoma(80;1e-25)|GBM - Glioblastoma multiforme(14;0.0169)			TCTAGTAGAGGTGAGTAGTCA	0.527000													26	42					0	0	0.134883	0	0
HOXC6	3223	broad.mit.edu	37	12	54422653	54422653	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr12:54422653G>C	ENST00000394331.3	+	2	1812	c.102G>C	c.(100-102)caG>caC	p.Q34H	RP11-834C11.12_ENST00000513209.1_Intron|HOXC4_ENST00000303406.4_Intron|HOXC6_ENST00000243108.4_Missense_Mutation_p.Q116H|RP11-834C11.14_ENST00000512206.1_RNA	NM_153693.4	NP_710160.1	P09630	HXC6_HUMAN	homeobox C6	116					regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(5)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						CCCAGGACCAGAAAGCCAGTA	0.463000													44	66					0	0	0.139131	0	0
TAS1R3	83756	broad.mit.edu	37	1	1269434	1269434	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:1269434G>A	ENST00000339381.5	+	6	2181	c.2149G>A	c.(2149-2151)Gag>Aag	p.E717K		NM_152228.1	NP_689414	Q7RTX0	TS1R3_HUMAN	taste receptor, type 1, member 3	717					detection of chemical stimulus involved in sensory perception of sweet taste|sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			kidney(2)|lung(8)|upper_aerodigestive_tract(1)|urinary_tract(1)	12	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.88e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.146)	Aspartame(DB00168)	GCTGCCCACGGAGGCGCTGGT	0.667000													8	22					0	0	0.038147	0	0
SAMD9	54809	broad.mit.edu	37	7	92735067	92735067	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr7:92735067T>C	ENST00000379958.2	-	3	613	c.344A>G	c.(343-345)aAg>aGg	p.K115R		NM_001193307.1|NM_017654.3	NP_001180236.1|NP_060124.2	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	115						cytoplasm				NS(1)|breast(4)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(20)|lung(32)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	88	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			CTCTTTACCCTTTTGTTTTTG	0.378000													3	148					0	0	0.009096	0	0
SIRPA	140885	broad.mit.edu	37	20	1918133	1918133	+	Silent	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr20:1918133C>G	ENST00000358771.4	+	8	1586	c.1434C>G	c.(1432-1434)ctC>ctG	p.L478L	SIRPA_ENST00000400068.3_Silent_p.L482L|SIRPA_ENST00000356025.3_Silent_p.L478L	NM_001040023.1	NP_001035112.1	P78324	SHPS1_HUMAN	signal-regulatory protein alpha	478					blood coagulation|cell adhesion|cell junction assembly|leukocyte migration	integral to membrane|plasma membrane	SH3 domain binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(13)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	21				Colorectal(46;0.018)|READ - Rectum adenocarcinoma(1;0.0556)		TGGTCCACCTCAACCGGACCC	0.642000													46	64					0	0	0.124865	0	0
SCAP	22937	broad.mit.edu	37	3	47460993	47460993	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr3:47460993C>T	ENST00000265565.5	-	13	2177	c.1765G>A	c.(1765-1767)Gag>Aag	p.E589K	SCAP_ENST00000545718.1_Missense_Mutation_p.E197K|SCAP_ENST00000441517.2_Missense_Mutation_p.E334K	NM_012235.2	NP_036367.2	Q12770	SCAP_HUMAN	SREBF chaperone	589					cholesterol metabolic process|negative regulation of cholesterol biosynthetic process|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane	unfolded protein binding			endometrium(4)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	26				BRCA - Breast invasive adenocarcinoma(193;0.000278)|KIRC - Kidney renal clear cell carcinoma(197;0.00592)|Kidney(197;0.00679)		GTCTGGTTCTCAGGTAGCTTA	0.647000													53	5					0	0	0.139131	0	0
ABCA13	154664	broad.mit.edu	37	7	48312658	48312658	+	Nonsense_Mutation	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr7:48312658C>G	ENST00000435803.1	+	17	3419	c.3395C>G	c.(3394-3396)tCa>tGa	p.S1132*		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	1132					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						TCAAACCTCTCAGCAAATGTC	0.353000													28	29					0	0	0.108266	0	0
STX4	6810	broad.mit.edu	37	16	31049910	31049910	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr16:31049910G>A	ENST00000394998.1	+	9	981	c.638G>A	c.(637-639)cGc>cAc	p.R213H	STX4_ENST00000493902.1_3'UTR|STX4_ENST00000313843.3_Missense_Mutation_p.R215H	NM_001272096.1	NP_001259025.1	Q12846	STX4_HUMAN	syntaxin 4	215	Interaction with CENPF (By similarity).|t-SNARE coiled-coil homology.				intracellular protein transport|platelet activation|post-Golgi vesicle-mediated transport	basolateral plasma membrane|cell surface|cytosol|integral to membrane|plasma membrane enriched fraction|specific granule|vacuole	SNAP receptor activity			NS(2)|breast(1)|large_intestine(3)|lung(3)	9						CAGCTTGAACGCAGTATTCGT	0.587000													31	35					0	0	0.125774	0	0
MYO18B	84700	broad.mit.edu	37	22	26164375	26164375	+	Silent	SNP	A	A	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr22:26164375A>G	ENST00000335473.7	+	4	742	c.492A>G	c.(490-492)tcA>tcG	p.S164S	MYO18B_ENST00000536101.1_Silent_p.S164S|MYO18B_ENST00000407587.2_Silent_p.S164S	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	164						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						ACCCGGACTCAGCCAAGCCAG	0.582000													3	22					0	0	0.115264	0	0
TP53	7157	broad.mit.edu	37	17	7573010	7573010	+	Splice_Site	SNP	T	T	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr17:7573010T>C	ENST00000420246.2	-	12	1366		c.e12-2		TP53_ENST00000359597.4_Intron|TP53_ENST00000413465.2_Intron|TP53_ENST00000455263.2_Splice_Site|TP53_ENST00000269305.4_Splice_Site|TP53_ENST00000445888.2_Splice_Site	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.?(3)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTCAGGTGGCTGTAGGAGACA	0.507000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			55	2					0	0	0.139131	0	0
NLRP14	338323	broad.mit.edu	37	11	7079545	7079545	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr11:7079545G>A	ENST00000299481.4	+	8	2843	c.2497G>A	c.(2497-2499)Gag>Aag	p.E833K		NM_176822.3	NP_789792.1	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	833					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			breast(3)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	21				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		GGCTGGCTGTGAGTATCTTTC	0.448000													49	46					0	0	0.139131	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95514946	95514946	+	RNA	SNP	C	C	T	rs143937878	by1000genomes	TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr2:95514946C>T	ENST00000432432.2	-	0	711					NR_040113.1													p.R201Q(1)									ACTACTGTACCGTCTCAGCCT	0.308000													3	79					0	0	0.014758	0	0
AATK	9625	broad.mit.edu	37	17	79095898	79095898	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr17:79095898G>A	ENST00000326724.4	-	11	1862	c.1838C>T	c.(1837-1839)tCg>tTg	p.S613L	AATK_ENST00000417379.1_Missense_Mutation_p.S510L	NM_001080395.2	NP_001073864.2	Q6ZMQ8	LMTK1_HUMAN	apoptosis-associated tyrosine kinase	613						integral to membrane|mitochondrion|perinuclear region of cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(2)|kidney(2)|lung(8)|ovary(3)|prostate(1)|stomach(4)|upper_aerodigestive_tract(1)	21	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			GGGCCCCGCCGAGGGCGAGGG	0.731000													7	5					0	0	0.047766	0	0
TUBGCP6	85378	broad.mit.edu	37	22	50657787	50657787	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr22:50657787C>G	ENST00000248846.5	-	19	4518	c.4414G>C	c.(4414-4416)Gtg>Ctg	p.V1472L	TUBGCP6_ENST00000491449.1_5'UTR|TUBGCP6_ENST00000439308.2_Silent_p.L1491L			Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	1472					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(4)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(13)|ovary(3)|prostate(2)|skin(2)	45		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		CTCAGCTGCACAGCAGTCTCA	0.682000													6	11					0	0	0.021553	0	0
MIA2	117153	broad.mit.edu	37	14	39721961	39721961	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr14:39721961C>G	ENST00000280082.3	+	5	1776	c.1577C>G	c.(1576-1578)tCt>tGt	p.S526C	RP11-407N17.3_ENST00000553728.1_Intron	NM_054024.3	NP_473365.3	Q96PC5	MIA2_HUMAN	melanoma inhibitory activity 2	526						extracellular region				NS(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	31	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0216)		GATATGGTCTCTAACATAGAG	0.343000													42	44					0	0	0.111260	0	0
SCN3A	6328	broad.mit.edu	37	2	165971968	165971968	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr2:165971968C>T	ENST00000360093.3	-	19	4002	c.3511G>A	c.(3511-3513)Gaa>Aaa	p.E1171K	SCN3A_ENST00000409101.3_Missense_Mutation_p.E1122K|SCN3A_ENST00000283254.7_Missense_Mutation_p.E1171K	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	1171						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	TGTTTACCTTCAGTAAAACAA	0.393000													32	1					0	0	0.069456	0	0
TGFBR3	7049	broad.mit.edu	37	1	92193232	92193232	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:92193232C>T	ENST00000212355.4	-	7	1334	c.869G>A	c.(868-870)gGa>gAa	p.G290E	TGFBR3_ENST00000370399.2_Missense_Mutation_p.G290E|TGFBR3_ENST00000525962.1_Missense_Mutation_p.G290E	NM_001195683.1|NM_003243.4	NP_001182612.1|NP_003234.2	Q03167	TGBR3_HUMAN	transforming growth factor, beta receptor III	290					BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	coreceptor activity|heparin binding|PDZ domain binding|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(24)|ovary(3)|prostate(4)|skin(1)|stomach(1)|urinary_tract(3)	55		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)		TTTCAGGCTTCCCTTAACATC	0.333000													22	37					0	0	0.076483	0	0
CTAGE9	643854	broad.mit.edu	37	6	132030013	132030013	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr6:132030013C>T	ENST00000314099.8	-	1	2193	c.2145G>A	c.(2143-2145)atG>atA	p.M715I	ENPP3_ENST00000357639.3_Intron|ENPP3_ENST00000414305.1_Intron|ENPP3_ENST00000358229.5_Intron	NM_001145659.1|NM_001278507.1	NP_001139131.1|NP_001265436.1	A4FU28	CTGE9_HUMAN	CTAGE family, member 9	715	Pro-rich.					integral to membrane				endometrium(1)|lung(1)	2						GTCCTCTTCTCATGAATGGGC	0.532000													74	110					0	0	0.139131	0	0
RIMS2	9699	broad.mit.edu	37	8	105261738	105261738	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr8:105261738G>T	ENST00000507740.1	+	20	3291	c.3055G>T	c.(3055-3057)Gac>Tac	p.D1019Y	RIMS2_ENST00000339750.2_Missense_Mutation_p.D141Y|RIMS2_ENST00000406091.3_Missense_Mutation_p.D1205Y|RIMS2_ENST00000436393.2_Missense_Mutation_p.D1223Y|RIMS2_ENST00000262231.10_Missense_Mutation_p.D1044Y	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1267					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			AGGAATGATGGACAAAAAGGG	0.413000										HNSCC(12;0.0054)			27	32					5.61819e-17	5.93421e-17	0.108266	1	0
ZBED4	9889	broad.mit.edu	37	22	50279761	50279761	+	Silent	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr22:50279761G>A	ENST00000216268.5	+	2	2928	c.2451G>A	c.(2449-2451)ctG>ctA	p.L817L		NM_014838.2	NP_055653.2	O75132	ZBED4_HUMAN	zinc finger, BED-type containing 4							cytoplasm|nucleus	DNA binding|metal ion binding|protein dimerization activity	p.L817L(1)		breast(2)|endometrium(3)|kidney(2)|large_intestine(11)|lung(20)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_cancers(38;8.58e-10)|all_epithelial(38;1.15e-08)|all_lung(38;0.000109)|Lung NSC(38;0.0018)|Breast(42;0.00191)|Ovarian(80;0.0164)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)|BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		GGAAGACGCTGAACGAGGGGG	0.612000													13	15					0	0	0.132662	0	0
HIST1H3C	8352	broad.mit.edu	37	6	26045687	26045687	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr6:26045687C>G	ENST00000540144.1	+	1	49	c.49C>G	c.(49-51)Ccg>Gcg	p.P17A		NM_003531.2	NP_003522.1	P68431	H31_HUMAN	histone cluster 1, H3c	17					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|ovary(1)|skin(1)	8						CGGCAAAGCTCCGCGCAAGCA	0.582000													30	35					0	0	0.144211	0	0
SNAP25	6616	broad.mit.edu	37	20	10286796	10286796	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr20:10286796G>C	ENST00000254976.2	+	8	783	c.572G>C	c.(571-573)aGa>aCa	p.R191T	SNAP25-AS1_ENST00000421143.2_RNA|SNAP25_ENST00000304886.2_Missense_Mutation_p.R191T|SNAP25-AS1_ENST00000453544.1_RNA|SNAP25_ENST00000495883.1_3'UTR	NM_130811.2	NP_570824.1	P60880	SNP25_HUMAN	synaptosomal-associated protein, 25kDa	191	t-SNARE coiled-coil homology 2.				energy reserve metabolic process|glutamate secretion|neurotransmitter uptake|synaptic vesicle docking involved in exocytosis	cell junction|growth cone|perinuclear region of cytoplasm|synapse|synaptosome				endometrium(1)|large_intestine(2)|lung(8)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	18					Botulinum Toxin Type A(DB00083)	AACAAAACCAGAATTGATGAG	0.488000													22	29					0	0	0.069288	0	0
LEPRE1	64175	broad.mit.edu	37	1	43212677	43212677	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:43212677G>T	ENST00000236040.4	-	14	2361	c.2321C>A	c.(2320-2322)tCa>tAa	p.S774*	LEPRE1_ENST00000462474.1_Intron|LEPRE1_ENST00000397054.3_Intron|LEPRE1_ENST00000296388.5_Intron	NM_001243246.1	NP_001230175.1	Q32P28	P3H1_HUMAN	leucine proline-enriched proteoglycan (leprecan) 1	0					negative regulation of cell proliferation	endoplasmic reticulum|proteinaceous extracellular matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			large_intestine(2)|lung(15)|ovary(5)|prostate(1)|urinary_tract(3)	26	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)			L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	AAGGACAGCTGAAGTGGGGCC	0.572000													36	75					1.69901e-12	1.76697e-12	0.080422	1	0
ZNF14	7561	broad.mit.edu	37	19	19825281	19825281	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr19:19825281C>T	ENST00000344099.3	-	2	157	c.19G>A	c.(19-21)Gag>Aag	p.E7K		NM_021030.2	NP_066358.2	P17017	ZNF14_HUMAN	zinc finger protein 14	7	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(2)|endometrium(1)|large_intestine(9)|lung(8)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	32		Renal(1328;0.0474)				GCCACATCCTCAAAGGAGACT	0.448000													26	32					0	0	0.099896	0	0
KMT2D	8085	broad.mit.edu	37	12	49431596	49431596	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr12:49431596C>G	ENST00000301067.7	-	34	9542	c.9543G>C	c.(9541-9543)gaG>gaC	p.E3181D		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		AGGAGGCCTTCTCAGCTGTGT	0.622000													11	9					0	0	0.069234	0	0
EXOC3	11336	broad.mit.edu	37	5	464428	464428	+	Silent	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr5:464428G>A	ENST00000512944.1	+	10	1866	c.1677G>A	c.(1675-1677)acG>acA	p.T559T	EXOC3_ENST00000315013.5_Silent_p.T559T	NM_007277.4	NP_009208.2	O60645	EXOC3_HUMAN	exocyst complex component 3	570					exocytosis|protein transport					breast(2)|cervix(1)|endometrium(4)|large_intestine(1)|lung(13)|ovary(1)|urinary_tract(1)	23		Ovarian(839;0.0563)	Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			AATTGATGACGAAGAAGTGGC	0.438000													26	30					0	0	0.091800	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96523140	96523140	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr2:96523140C>G	ENST00000456556.1	-	62	4081	c.3997G>C	c.(3997-3999)Gaa>Caa	p.E1333Q	ANKRD36C_ENST00000420871.2_Missense_Mutation_p.E584Q|ANKRD36C_ENST00000419039.2_Missense_Mutation_p.E360Q					ankyrin repeat domain 36C											breast(1)|endometrium(8)|kidney(5)|lung(4)	18						ACATCAGCTTCTATCCTATAT	0.348000													27	0					0	0	0.125774	0	0
ABCC3	8714	broad.mit.edu	37	17	48761319	48761319	+	Missense_Mutation	SNP	G	G	A	rs142763506		TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr17:48761319G>A	ENST00000285238.8	+	28	4044	c.3964G>A	c.(3964-3966)Gtg>Atg	p.V1322M		NM_003786.3	NP_003777.2	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	1322	ABC transporter 2.				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	GGTGGGGATCGTGGGCCGCAC	0.612000													25	40					0	0	0.116897	0	0
IL17RA	23765	broad.mit.edu	37	22	17589995	17589995	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr22:17589995C>G	ENST00000319363.6	+	13	2019	c.1886C>G	c.(1885-1887)tCc>tGc	p.S629C		NM_014339.5	NP_055154.3	Q96F46	I17RA_HUMAN	interleukin 17 receptor A	629					fibroblast activation|positive regulation of interleukin-23 production	integral to plasma membrane	interleukin-17 receptor activity			endometrium(2)|large_intestine(8)|lung(16)|ovary(1)|skin(2)|stomach(1)	30		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.241)		GAGCCTGGCTCCCAGGCCTGC	0.697000													5	12					0	0	0.029380	0	0
NFX1	4799	broad.mit.edu	37	9	33294813	33294813	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr9:33294813G>C	ENST00000379540.3	+	2	483	c.421G>C	c.(421-423)Gag>Cag	p.E141Q	NFX1_ENST00000379521.4_Missense_Mutation_p.E141Q|NFX1_ENST00000318524.6_Missense_Mutation_p.E141Q	NM_002504.4	NP_002495.2	Q12986	NFX1_HUMAN	nuclear transcription factor, X-box binding 1	141					inflammatory response|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|ligase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(4)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	25			LUSC - Lung squamous cell carcinoma(29;0.00506)	GBM - Glioblastoma multiforme(74;0.224)		GACCAGATCAGAGAGTGGGAC	0.483000													54	52					0	0	0.139131	0	0
STT3A	3703	broad.mit.edu	37	11	125481355	125481355	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr11:125481355G>A	ENST00000392708.4	+	11	1309	c.1150G>A	c.(1150-1152)Gat>Aat	p.D384N	STT3A_ENST00000529196.1_Missense_Mutation_p.D384N|STT3A_ENST00000531491.1_Missense_Mutation_p.D292N	NM_001278503.1|NM_001278504.1|NM_152713.3	NP_001265432.1|NP_001265433.1|NP_689926.1	P46977	STT3A_HUMAN	STT3A, subunit of the oligosaccharyltransferase complex (catalytic)	384					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity			NS(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(15)|skin(1)	33	all_hematologic(175;0.228)	Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0919)|all_lung(97;0.0994)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0996)		CAACCTGTCTGATGCCCGGAT	0.428000													79	99					0	0	0.139131	0	0
TINAGL1	64129	broad.mit.edu	37	1	32051391	32051391	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:32051391G>C	ENST00000271064.7	+	10	1207	c.1131G>C	c.(1129-1131)aaG>aaC	p.K377N	TINAGL1_ENST00000457433.2_Missense_Mutation_p.K346N|TINAGL1_ENST00000481165.1_3'UTR	NM_001204415.1|NM_022164.2	NP_001191344.1|NP_071447.1	Q9GZM7	TINAL_HUMAN	tubulointerstitial nephritis antigen-like 1	377				K -> E (in Ref. 8; BAB55403).	endosome transport|immune response|proteolysis	extracellular region	cysteine-type endopeptidase activity|extracellular matrix structural constituent|polysaccharide binding|scavenger receptor activity			breast(2)|central_nervous_system(1)|kidney(3)|large_intestine(3)|lung(4)|prostate(1)|skin(3)|urinary_tract(1)	18		Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		STAD - Stomach adenocarcinoma(196;0.0526)|READ - Rectum adenocarcinoma(331;0.145)		TCCTATACAAGGGAGGCATCT	0.602000													34	11					0	0	0.074837	0	0
VWA7	80737	broad.mit.edu	37	6	31737819	31737819	+	Missense_Mutation	SNP	C	C	G	rs139629177	byFrequency	TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr6:31737819C>G	ENST00000375686.3	-	8	1396	c.1159G>C	c.(1159-1161)Ggg>Cgg	p.G387R	VWA7_ENST00000447450.1_Missense_Mutation_p.G387R|VWA7_ENST00000375688.4_Missense_Mutation_p.G387R|VWA7_ENST00000467576.1_5'UTR	NM_025258.2	NP_079534.2	Q9Y334	G7C_HUMAN	von Willebrand factor A domain containing 7	387						extracellular region											TCTCCACCCCCCAAGGCATGG	0.592000													26	31					0	0	0.099896	0	0
MR1	3140	broad.mit.edu	37	1	181021468	181021468	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:181021468G>C	ENST00000367580.5	+	4	707	c.702G>C	c.(700-702)atG>atC	p.M234I	MR1_ENST00000434571.2_Intron|MR1_ENST00000282990.6_Intron|MR1_ENST00000367579.3_Missense_Mutation_p.M189I|MR1_ENST00000438435.2_Intron	NM_001531.2	NP_001522.1	Q95460	HMR1_HUMAN	major histocompatibility complex, class I-related	234	Alpha-3.|Ig-like C1-type.				antigen processing and presentation of peptide antigen via MHC class I|immune response	endoplasmic reticulum|extracellular region|integral to membrane|MHC class I protein complex	MHC class I receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(2)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	18						AAATTTACATGACATGGATGA	0.458000													32	34					0	0	0.059317	0	0
MT1E	4493	broad.mit.edu	37	16	56660452	56660452	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr16:56660452G>A	ENST00000330439.6	+	2	157	c.103G>A	c.(103-105)Ggg>Agg	p.G35R	MT1E_ENST00000568293.1_Intron|MT1E_ENST00000306061.6_Intron			P04732	MT1E_HUMAN	metallothionein 1E	0	Alpha.					cytoplasm	cadmium ion binding|copper ion binding|zinc ion binding										GAGTGAGTGCGGGGCCATCTC	0.592000													27	41					0	0	0.050027	0	0
HINFP	25988	broad.mit.edu	37	11	119003250	119003250	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr11:119003250G>C	ENST00000350777.2	+	6	784	c.721G>C	c.(721-723)Gag>Cag	p.E241Q	HINFP_ENST00000527410.1_Missense_Mutation_p.E241Q	NM_001243259.1|NM_015517.4|NM_198971.2	NP_001230188.1|NP_056332.2|NP_945322.1	Q9BQA5	HINFP_HUMAN	histone H4 transcription factor	241					DNA damage checkpoint|DNA repair|establishment of protein localization|in utero embryonic development|myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	enzyme binding|histone binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23						ATTTGCCACAGAGCGGCTATT	0.587000													59	64					0	0	0.139131	0	0
THSD7B	80731	broad.mit.edu	37	2	138414689	138414689	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr2:138414689G>A	ENST00000409968.1	+	24	4512	c.4334G>A	c.(4333-4335)cGa>cAa	p.R1445Q	THSD7B_ENST00000413152.2_Missense_Mutation_p.R1417Q|THSD7B_ENST00000272643.3_Missense_Mutation_p.R1448Q|THSD7B_ENST00000543459.1_Missense_Mutation_p.E280K					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		AATAACGAACGAACTGTATGG	0.413000													25	2					0	0	0.108266	0	0
ATG14	22863	broad.mit.edu	37	14	55857644	55857644	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr14:55857644C>G	ENST00000247178.5	-	4	429	c.394G>C	c.(394-396)Gaa>Caa	p.E132Q		NM_014924.4	NP_055739.2	Q6ZNE5	BAKOR_HUMAN	autophagy related 14	132					autophagic vacuole assembly|positive regulation of autophagy	autophagic vacuole|endoplasmic reticulum|pre-autophagosomal structure membrane	protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(6)|prostate(2)	13						TCCATTTCTTCATTTCCTTTA	0.343000													2	15					0	0	0.115264	0	0
TUBGCP2	10844	broad.mit.edu	37	10	135107159	135107159	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr10:135107159C>A	ENST00000368563.2	-	6	1087	c.731G>T	c.(730-732)cGg>cTg	p.R244L	TUBGCP2_ENST00000543663.1_Missense_Mutation_p.R272L|TUBGCP2_ENST00000252936.3_Missense_Mutation_p.R244L|TUBGCP2_ENST00000417178.2_Missense_Mutation_p.R114L	NM_001256617.1|NM_006659.3	NP_001243546.1|NP_006650.1	Q9BSJ2	GCP2_HUMAN	tubulin, gamma complex associated protein 2	244					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytoplasmic microtubule|cytosol|spindle pole	protein binding			breast(2)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(16)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	35		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.87e-06)|all cancers(32;8.98e-06)|Epithelial(32;1.15e-05)		GAGGAAGGTCCGGCTCTGCCT	0.677000													3	5					0.004672	0.00471384	0.115264	1	0
LRRIQ1	84125	broad.mit.edu	37	12	85439894	85439894	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr12:85439894A>G	ENST00000393217.2	+	5	494	c.433A>G	c.(433-435)Atg>Gtg	p.M145V		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	145										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		TGACTTGCCTATGGATGAACA	0.318000													29	58					0	0	0.125774	0	0
ACE2	59272	broad.mit.edu	37	X	15588451	15588451	+	Silent	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chrX:15588451C>T	ENST00000427411.1	-	15	2079	c.1863G>A	c.(1861-1863)agG>agA	p.R621R	ACE2_ENST00000252519.3_Silent_p.R621R	NM_021804.2	NP_068576.1	Q9BYF1	ACE2_HUMAN	angiotensin I converting enzyme 2	621					angiotensin-mediated drinking behavior|proteolysis|receptor biosynthetic process|regulation of cell proliferation|virion attachment, binding of host cell surface receptor	cell surface|extracellular space|integral to membrane|membrane raft|plasma membrane	carboxypeptidase activity|glycoprotein binding|metallopeptidase activity|peptidyl-dipeptidase activity|viral receptor activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(10)|lung(10)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	32	Hepatocellular(33;0.183)				Moexipril(DB00691)	TTAGGCTTATCCTCACTTTGA	0.388000													32	0					0	0	0.144211	0	0
FBL	2091	broad.mit.edu	37	19	40331067	40331067	+	Silent	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr19:40331067C>T	ENST00000221801.3	-	3	383	c.270G>A	c.(268-270)ccG>ccA	p.P90P		NM_001436.3	NP_001427.2	P22087	FBRL_HUMAN	fibrillarin	90					rRNA processing|tRNA processing	box C/D snoRNP complex|Cajal body	methyltransferase activity|protein binding|RNA binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)	9	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)	Renal(1328;0.000518)|Hepatocellular(1079;0.0893)	Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)	GBM - Glioblastoma multiforme(1328;0.000826)|STAD - Stomach adenocarcinoma(1328;0.138)		CATGCCGATGCGGCTCCACCA	0.622000													5	286					0	0	0.021553	0	0
SYNE2	23224	broad.mit.edu	37	14	64514862	64514862	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr14:64514862G>C	ENST00000358025.3	+	46	7596	c.7366G>C	c.(7366-7368)Gaa>Caa	p.E2456Q	SYNE2_ENST00000554584.1_Missense_Mutation_p.E2489Q|SYNE2_ENST00000357395.3_5'UTR|SYNE2_ENST00000344113.4_Missense_Mutation_p.E2456Q	NM_182914.2	NP_878918.2	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	2456					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TGAACAATTAGAAGAGATAGA	0.323000													10	15					0	0	0.080935	0	0
GLCE	26035	broad.mit.edu	37	15	69560600	69560600	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr15:69560600G>C	ENST00000261858.2	+	5	1099	c.871G>C	c.(871-873)Gat>Cat	p.D291H	GLCE_ENST00000559500.1_3'UTR|GLCE_ENST00000559420.2_Missense_Mutation_p.D227H	NM_015554.1	NP_056369.1	O94923	GLCE_HUMAN	glucuronic acid epimerase	291					heparan sulfate proteoglycan biosynthetic process|heparin biosynthetic process	Golgi membrane|integral to membrane	UDP-glucuronate 5'-epimerase activity			NS(1)|breast(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	18						AAACACAAAAGATTTTATTAT	0.363000													23	1					0	0	0.083992	0	0
ZNF41	7592	broad.mit.edu	37	X	47308245	47308245	+	Silent	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chrX:47308245G>A	ENST00000377065.4	-	5	1563	c.924C>T	c.(922-924)ttC>ttT	p.F308F	ZNF41_ENST00000313116.7_Silent_p.F308F|ZNF41_ENST00000397050.2_Silent_p.F318F	NM_153380.2	NP_700359.1	P51814	ZNF41_HUMAN	zinc finger protein 41	350						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(8)|ovary(3)|upper_aerodigestive_tract(2)	24		all_lung(315;0.000129)				GTTTCTGGGGGAAGACTTTGT	0.423000													64	3					0	0	0.139131	0	0
ZNF606	80095	broad.mit.edu	37	19	58511212	58511212	+	Silent	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr19:58511212C>T	ENST00000341164.4	-	4	761	c.141G>A	c.(139-141)ggG>ggA	p.G47G	ZNF606_ENST00000547121.1_Silent_p.G47G|ZNF606_ENST00000552579.1_Intron|ZNF606_ENST00000547828.1_Silent_p.G47G|ZNF606_ENST00000536132.1_Intron	NM_025027.3	NP_079303.2	Q8WXB4	ZN606_HUMAN	zinc finger protein 606	47					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)		TGGCCCTCCTCCCCTCCTCCA	0.597000													36	46					0	0	0.086207	0	0
KMT2D	8085	broad.mit.edu	37	12	49432123	49432123	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr12:49432123C>T	ENST00000301067.7	-	34	9015	c.9016G>A	c.(9016-9018)Gat>Aat	p.D3006N		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		AGCTCTTCATCATCCTCTAGG	0.567000													27	32					0	0	0.099896	0	0
CLCN1	1180	broad.mit.edu	37	7	143036680	143036680	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr7:143036680C>G	ENST00000343257.2	+	14	1635	c.1548C>G	c.(1546-1548)atC>atG	p.I516M		NM_000083.2	NP_000074	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	516					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					ATGACATCATCTACAAGATCC	0.433000													20	33					0	0	0.049695	0	0
OPN3	23596	broad.mit.edu	37	1	241767757	241767757	+	Silent	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:241767757C>T	ENST00000366554.2	-	2	604	c.498G>A	c.(496-498)ctG>ctA	p.L166L	OPN3_ENST00000331838.5_Intron|OPN3_ENST00000469376.1_5'UTR	NM_014322.2	NP_055137.2	Q9H1Y3	OPN3_HUMAN	opsin 3	166					phototransduction|protein-chromophore linkage|regulation of circadian rhythm|visual perception	integral to plasma membrane	G-protein coupled photoreceptor activity			endometrium(1)|large_intestine(5)|lung(5)	11	Ovarian(103;0.103)|all_lung(81;0.23)	all_cancers(173;0.0231)	OV - Ovarian serous cystadenocarcinoma(106;0.0125)			CTGCCCACGCCAGTGAGTAGA	0.552000													23	26					0	0	0.091800	0	0
GTF3C1	2975	broad.mit.edu	37	16	27544611	27544611	+	Splice_Site	SNP	C	C	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr16:27544611C>A	ENST00000356183.4	-	5	865		c.e5+1		GTF3C1_ENST00000561623.1_Splice_Site	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa							transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						CCCAGGCTCACCAGCTCTTCC	0.552000													21	33					1.50039e-11	1.54613e-11	0.062417	1	0
ZIC1	7545	broad.mit.edu	37	3	147128051	147128051	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr3:147128051C>A	ENST00000282928.4	+	1	881	c.152C>A	c.(151-153)cCc>cAc	p.P51H		NM_003412.3	NP_003403.2	Q15915	ZIC1_HUMAN	Zic family member 1	51					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(4)|cervix(1)|endometrium(2)|large_intestine(8)|lung(38)|ovary(1)|prostate(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	63						AAGCTCAACCCCAGTTCGCAC	0.726000													11	26					1.05317e-09	1.07544e-09	0.119110	1	0
SETD6	79918	broad.mit.edu	37	16	58550749	58550749	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr16:58550749G>C	ENST00000394266.4	+	6	558	c.502G>C	c.(502-504)Gag>Cag	p.E168Q	SETD6_ENST00000310682.2_Missense_Mutation_p.E213Q|SETD6_ENST00000418480.1_3'UTR|SETD6_ENST00000219315.4_Missense_Mutation_p.E237Q			Q8TBK2	SETD6_HUMAN	SET domain containing 6	237	SET.				negative regulation of NF-kappaB transcription factor activity|peptidyl-lysine monomethylation|regulation of inflammatory response	nucleus	NF-kappaB binding|protein-lysine N-methyltransferase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|skin(1)	7						GGATGAAAAGGAGCCCAACTC	0.522000													68	105					0	0	0.139131	0	0
ZKSCAN4	387032	broad.mit.edu	37	6	28219623	28219623	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr6:28219623C>T	ENST00000377294.2	-	1	379	c.136G>A	c.(136-138)Gct>Act	p.A46T	ZKSCAN4_ENST00000423974.2_Intron	NM_019110.3	NP_061983.2	Q969J2	ZKSC4_HUMAN	zinc finger with KRAB and SCAN domains 4	46					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.A46T(1)		endometrium(2)|large_intestine(2)|lung(10)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	18						GGGCCCCGAGCAGGGCTGCAG	0.711000													37	38					0	0	0.064281	0	0
EHF	26298	broad.mit.edu	37	11	34680084	34680084	+	Silent	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr11:34680084G>C	ENST00000257831.3	+	8	733	c.612G>C	c.(610-612)ccG>ccC	p.P204P	EHF_ENST00000533754.1_Silent_p.P204P|EHF_ENST00000531794.1_Silent_p.P226P|EHF_ENST00000450654.2_Silent_p.P181P|EHF_ENST00000530286.1_Silent_p.P204P	NM_012153.5	NP_036285.2	Q9NZC4	EHF_HUMAN	ets homologous factor	204					cell proliferation|epithelial cell differentiation|multicellular organismal development|positive regulation of transcription, DNA-dependent		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.P204P(1)	NFIA/EHF(2)	autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(3)|lung(8)|upper_aerodigestive_tract(1)	17		all_hematologic(20;0.117)	Epithelial(1;0.055)|all cancers(1;0.137)|STAD - Stomach adenocarcinoma(6;0.235)			CATCAGACCCGAGAGGGACTC	0.468000													37	39					0	0	0.092188	0	0
GJA5	2702	broad.mit.edu	37	1	147230969	147230969	+	Silent	SNP	C	C	T	rs112980895		TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:147230969C>T	ENST00000271348.2	-	2	539	c.378G>A	c.(376-378)ccG>ccA	p.P126P	GJA5_ENST00000369237.1_Silent_p.P126P	NM_005266.5	NP_005257.2	P36382	CXA5_HUMAN	gap junction protein, alpha 5, 40kDa	126					angiogenesis|cell-cell junction assembly|muscle contraction	integral to membrane				breast(3)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	20	all_hematologic(923;0.0276)		LUSC - Lung squamous cell carcinoma(543;0.202)			TCTCTGCCACCGGGTACTCGT	0.612000													5	124					0	0	0.014758	0	0
WDFY3	23001	broad.mit.edu	37	4	85672638	85672638	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr4:85672638C>G	ENST00000322366.6	-	36	6378	c.5971G>C	c.(5971-5973)Gag>Cag	p.E1991Q	WDFY3_ENST00000295888.4_Missense_Mutation_p.E1991Q			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	1991						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TTCTTTACCTCCAACAAAAGA	0.348000													32	35					0	0	0.144211	0	0
LY9	4063	broad.mit.edu	37	1	160784451	160784451	+	Silent	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:160784451C>T	ENST00000368037.5	+	4	1086	c.972C>T	c.(970-972)atC>atT	p.I324I	LY9_ENST00000341032.4_Silent_p.I324I|LY9_ENST00000392203.4_Silent_p.I324I|LY9_ENST00000368041.2_Silent_p.I284I|LY9_ENST00000368040.1_5'UTR|LY9_ENST00000263285.6_Silent_p.I324I	NM_001261456.1|NM_002348.3	NP_001248385.1|NP_002339.2	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9		Ig-like V-type 2.				cell adhesion|immunoglobulin mediated immune response	integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CCCTGAAGATCAGCCAGCTGA	0.562000													17	24					0	0	0.146539	0	0
TTC23L	153657	broad.mit.edu	37	5	34850409	34850409	+	Silent	SNP	G	G	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr5:34850409G>T	ENST00000505624.1	+	4	478	c.375G>T	c.(373-375)ctG>ctT	p.L125L	TTC23L_ENST00000514080.1_3'UTR	NM_144725.3	NP_653326.3	Q6PF05	TT23L_HUMAN	tetratricopeptide repeat domain 23-like	125							binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(9)|prostate(2)|stomach(1)|urinary_tract(1)	22						ACTTGACACTGAGAGGTACTT	0.527000													47	62					2.13384e-23	2.29693e-23	0.139131	1	0
GAS2L1	10634	broad.mit.edu	37	22	29704254	29704254	+	Silent	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr22:29704254G>C	ENST00000471961.1	+	1	1207	c.159G>C	c.(157-159)ctG>ctC	p.L53L	GAS2L1_ENST00000341313.6_Silent_p.L53L|GAS2L1_ENST00000407854.1_Silent_p.L53L|GAS2L1_ENST00000403764.1_Silent_p.L53L|GAS2L1_ENST00000360113.2_Silent_p.L53L|GAS2L1_ENST00000406549.3_Silent_p.L53L|GAS2L1_ENST00000407647.2_Silent_p.L53L			Q99501	GA2L1_HUMAN	growth arrest-specific 2 like 1	53	CH.				cell cycle arrest	cytoplasm|cytoskeleton				endometrium(2)|lung(2)|prostate(1)	5						ATGGCTTCCTGACAGGGCTGG	0.692000													10	15					0	0	0.069234	0	0
PCDHB1	29930	broad.mit.edu	37	5	140433468	140433468	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr5:140433468C>G	ENST00000306549.3	+	1	2490	c.2413C>G	c.(2413-2415)Cag>Gag	p.Q805E		NM_013340.2	NP_037472.2	Q9Y5F3	PCDB1_HUMAN		805					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|liver(1)|lung(13)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	53			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAATAAGTCTCAGAGATTAGA	0.438000													30	59					0	0	0.125774	0	0
BRAF	673	broad.mit.edu	37	7	140534445	140534445	+	Silent	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr7:140534445G>A	ENST00000288602.6	-	3	528	c.468C>T	c.(466-468)atC>atT	p.I156I		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	156	RBD.				activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding		SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	AGACTCTAACGATAGGTTTTT	0.423000		61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				42	41					0	0	0.124865	0	0
LIMA1	51474	broad.mit.edu	37	12	50642451	50642451	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr12:50642451C>A	ENST00000341247.4	-	2	233	c.84G>T	c.(82-84)aaG>aaT	p.K28N	LIMA1_ENST00000394943.3_Missense_Mutation_p.K28N	NM_001113546.1|NM_016357.4	NP_001107018.1|NP_057441.1	Q9UHB6	LIMA1_HUMAN	LIM domain and actin binding 1	28					actin filament bundle assembly|negative regulation of actin filament depolymerization|ruffle organization	cytoplasm|focal adhesion|stress fiber	actin filament binding|actin monomer binding|zinc ion binding			NS(1)|breast(4)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(2)	44						ATGACTTGTTCTTGTTGACAA	0.443000													53	60					6.34439e-16	6.68039e-16	0.139131	1	0
PAN2	9924	broad.mit.edu	37	12	56721370	56721370	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr12:56721370C>G	ENST00000425394.2	-	6	1073	c.697G>C	c.(697-699)Gat>Cat	p.D233H	PAN2_ENST00000440411.3_Missense_Mutation_p.D233H|PAN2_ENST00000548043.1_Missense_Mutation_p.D233H|PAN2_ENST00000257931.5_Missense_Mutation_p.D233H	NM_001127460.2	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)	233					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	41						GAGAAGGCATCAAACTCATGT	0.473000													39	36					0	0	0.117977	0	0
C2CD2	25966	broad.mit.edu	37	21	43309389	43309389	+	Silent	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr21:43309389G>C	ENST00000380486.3	-	14	2176	c.1935C>G	c.(1933-1935)ggC>ggG	p.G645G	C2CD2_ENST00000329623.7_Silent_p.G490G	NM_015500.1	NP_056315.1	Q9Y426	CU025_HUMAN	C2 calcium-dependent domain containing 2	645						cytosol|extracellular region|nucleus				endometrium(2)|kidney(1)|large_intestine(4)|lung(3)|ovary(3)|prostate(1)|stomach(1)	15						ACTGACTCATGCCTGGGTCTT	0.557000													21	29					0	0	0.069288	0	0
HIST1H2BM	8342	broad.mit.edu	37	6	27783043	27783043	+	Silent	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr6:27783043C>T	ENST00000359465.4	+	1	222	c.222C>T	c.(220-222)atC>atT	p.I74I		NM_003521.2	NP_003512.1	Q99879	H2B1M_HUMAN	histone cluster 1, H2bm	74					nucleosome assembly	nucleosome|nucleus	DNA binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(2)	12						TTGAGCGTATCGCCGGAGAAG	0.572000													46	57					0	0	0.131918	0	0
NUDT8	254552	broad.mit.edu	37	11	67397191	67397191	+	Silent	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr11:67397191G>C	ENST00000301490.4	-	1	210	c.192C>G	c.(190-192)gtC>gtG	p.V64V	NUDT8_ENST00000376693.2_Silent_p.V64V	NM_181843.2	NP_862826.1	Q8WV74	NUDT8_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 8	64	Nudix hydrolase.					mitochondrion	hydrolase activity|metal ion binding			endometrium(1)|lung(1)|prostate(1)|skin(1)	4						CGCTGTACCTGACGTCGCCCT	0.721000													2	6					0	0	0.115264	0	0
CHML	1122	broad.mit.edu	37	1	241798632	241798632	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:241798632G>A	ENST00000366553.1	-	1	600	c.437C>T	c.(436-438)tCg>tTg	p.S146L	OPN3_ENST00000331838.5_Intron|OPN3_ENST00000366554.2_Intron|OPN3_ENST00000469376.1_Intron	NM_001821.3	NP_001812.2	P26374	RAE2_HUMAN	choroideremia-like (Rab escort protein 2)	146					intracellular protein transport|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(7)|ovary(4)|skin(3)|stomach(1)	26	Ovarian(103;0.103)|all_lung(81;0.23)	all_cancers(173;0.0231)	OV - Ovarian serous cystadenocarcinoma(106;0.0125)			ATTAAAATACGATAACTGGCT	0.403000													76	101					0	0	0.139131	0	0
GPR85	54329	broad.mit.edu	37	7	112724516	112724516	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr7:112724516C>T	ENST00000297146.3	-	3	864	c.261G>A	c.(259-261)tgG>tgA	p.W87*	GPR85_ENST00000424100.1_Nonsense_Mutation_p.W87*|GPR85_ENST00000449591.1_Nonsense_Mutation_p.W87*|GPR85_ENST00000501255.2_Nonsense_Mutation_p.W87*	NM_001146266.1	NP_001139738.1	P60893	GPR85_HUMAN	G protein-coupled receptor 85							integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	17						TCCCATAAGTCCAGGTAGAAC	0.428000													25	42					0	0	0.099896	0	0
GSTM2	2946	broad.mit.edu	37	1	110211575	110211575	+	Silent	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:110211575G>A	ENST00000369831.2	+	3	235	c.141G>A	c.(139-141)ctG>ctA	p.L47L	GSTM2_ENST00000369829.2_Silent_p.L47L|GSTM2_ENST00000414179.2_5'UTR|GSTM2_ENST00000442650.1_Silent_p.L47L|GSTM2_ENST00000464206.1_3'UTR|GSTM2_ENST00000460717.3_Silent_p.L47L|GSTM2_ENST00000369827.3_Silent_p.L45L|GSTM2_ENST00000241337.4_Silent_p.L47L					glutathione S-transferase mu 2 (muscle)											kidney(1)|large_intestine(2)|lung(4)|prostate(2)|upper_aerodigestive_tract(2)	11		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		all cancers(265;0.0122)|Colorectal(144;0.0129)|Epithelial(280;0.0146)|Lung(183;0.0422)|COAD - Colon adenocarcinoma(174;0.047)|LUSC - Lung squamous cell carcinoma(189;0.227)		GCCAGTGGCTGAATGAAAAAT	0.547000													33	28					0	0	0.139131	0	0
RCCD1	91433	broad.mit.edu	37	15	91504898	91504898	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr15:91504898C>T	ENST00000394258.2	+	8	1232	c.1030C>T	c.(1030-1032)Cgc>Tgc	p.R344C	RCCD1_ENST00000555155.1_Missense_Mutation_p.R342C|RCCD1_ENST00000556618.1_Missense_Mutation_p.R344C	NM_001017919.1|NM_033544.2	NP_001017919.1|NP_291022.2	A6NED2	RCCD1_HUMAN	RCC1 domain containing 1	344								p.R344C(1)		breast(1)|kidney(1)|large_intestine(2)	4	Lung NSC(78;0.0987)|all_lung(78;0.175)		Lung(145;0.189)			GGATCGGCCTCGCCGTGTGGA	0.532000													40	1					0	0	0.080422	0	0
PROX2	283571	broad.mit.edu	37	14	75329988	75329988	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr14:75329988G>A	ENST00000556084.2	-	1	549	c.550C>T	c.(550-552)Cgc>Tgc	p.R184C	PROX2_ENST00000445876.1_Missense_Mutation_p.R184C|PROX2_ENST00000556489.2_Missense_Mutation_p.R184C	NM_001080408.2	NP_001073877.2	Q3B8N5	PROX2_HUMAN	prospero homeobox 2	184					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			kidney(1)|large_intestine(2)|lung(3)	6			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00652)		ACCCAGGGGCGAGGCCCACAG	0.617000													27	35					0	0	0.108266	0	0
BDP1	55814	broad.mit.edu	37	5	70754468	70754468	+	Nonsense_Mutation	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr5:70754468C>G	ENST00000358731.4	+	2	538	c.275C>G	c.(274-276)tCa>tGa	p.S92*	BDP1_ENST00000380675.2_5'UTR	NM_018429.2	NP_060899.2	A6H8Y1	BDP1_HUMAN	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	92	Interaction with ZBTB43.|Ser-rich.				regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			NS(2)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(34)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		TCTACTGTTTCACAGAGAAGA	0.373000													57	60					0	0	0.139131	0	0
COL17A1	1308	broad.mit.edu	37	10	105831838	105831838	+	Splice_Site	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr10:105831838C>G	ENST00000353479.5	-	8	706		c.e8-1		COL17A1_ENST00000369733.3_Splice_Site|COL17A1_ENST00000393211.3_Splice_Site	NM_000494.3	NP_000485.3	Q9UMD9	COHA1_HUMAN	collagen, type XVII, alpha 1						cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|liver(1)|lung(22)|ovary(5)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	62		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		ATTTCACTCTCTGTACAAGGG	0.498000													23	38					0	0	0.076483	0	0
KCTD7	154881	broad.mit.edu	37	7	66264377	66264377	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr7:66264377G>C	ENST00000380828.2	+	9	1070	c.916G>C	c.(916-918)Gat>Cat	p.D306H	RABGEF1_ENST00000484547.2_3'UTR|RABGEF1_ENST00000439720.2_Missense_Mutation_p.D279H|KCTD7_ENST00000451741.2_Missense_Mutation_p.D266H|KCTD7_ENST00000510829.2_Missense_Mutation_p.D266H|RABGEF1_ENST00000284957.5_Missense_Mutation_p.D266H|RABGEF1_ENST00000437078.2_Missense_Mutation_p.D280H|RABGEF1_ENST00000450873.2_Missense_Mutation_p.D266H			Q96MP8	KCTD7_HUMAN	potassium channel tetramerization domain containing 7	243						voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|urinary_tract(1)	16						AGAAGTGTCTGATATGGTGGT	0.433000													27	28					0	0	0.144211	0	0
ZNF836	162962	broad.mit.edu	37	19	52659499	52659499	+	Silent	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr19:52659499G>A	ENST00000322146.8	-	5	1958	c.1437C>T	c.(1435-1437)ttC>ttT	p.F479F	ZNF836_ENST00000597252.1_Silent_p.F479F|CTC-471J1.8_ENST00000594362.1_RNA	NM_001102657.1	NP_001096127.1	Q6ZNA1	ZN836_HUMAN	zinc finger protein 836	479					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.F479F(2)		endometrium(2)|kidney(2)|large_intestine(9)|lung(10)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26						AAGTCTGACTGAAGACCTTGC	0.428000													50	52					0	0	0.139131	0	0
ZNF335	63925	broad.mit.edu	37	20	44578480	44578480	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr20:44578480C>G	ENST00000322927.2	-	24	3728	c.3628G>C	c.(3628-3630)Gat>Cat	p.D1210H	ZNF335_ENST00000426788.1_Missense_Mutation_p.D1055H	NM_022095.3	NP_071378.1	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	1210	Gln-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(13)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	51		Myeloproliferative disorder(115;0.0122)				GTCTGGCCATCTGCCGTGGTG	0.582000													31	38					0	0	0.054565	0	0
HSPA2	3306	broad.mit.edu	37	14	65009011	65009011	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr14:65009011G>A	ENST00000247207.6	+	1	1826	c.1444G>A	c.(1444-1446)Gac>Aac	p.D482N	HSPA2_ENST00000394709.1_Missense_Mutation_p.D482N	NM_021979.3	NP_068814.2	P54652	HSP72_HUMAN	heat shock 70kDa protein 2	482					response to unfolded protein|spermatid development	cell surface	ATP binding|unfolded protein binding			breast(1)|endometrium(4)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	22				all cancers(60;0.00515)|OV - Ovarian serous cystadenocarcinoma(108;0.00584)|BRCA - Breast invasive adenocarcinoma(234;0.045)		GGTTACCTTCGACATTGACGC	0.557000													36	28					0	0	0.074837	0	0
SH3GLB2	56904	broad.mit.edu	37	9	131777141	131777141	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr9:131777141C>G	ENST00000372564.3	-	4	522	c.377G>C	c.(376-378)gGa>gCa	p.G126A	SH3GLB2_ENST00000417224.1_Missense_Mutation_p.G126A|SH3GLB2_ENST00000416629.1_Missense_Mutation_p.G126A|SH3GLB2_ENST00000372559.1_Missense_Mutation_p.G126A|SH3GLB2_ENST00000372554.4_Missense_Mutation_p.G126A	NM_020145.2	NP_064530.1	Q9NR46	SHLB2_HUMAN	SH3-domain GRB2-like endophilin B2	126	BAR.				filopodium assembly|signal transduction	cytoplasm|nucleus	cytoskeletal adaptor activity|SH3 domain binding			NS(1)|kidney(1)|large_intestine(3)|liver(1)|lung(4)|ovary(1)|prostate(1)	12						CTCCGCGGCTCCCAGTTGCTT	0.552000													63	3					0	0	0.139131	0	0
SCNN1A	6337	broad.mit.edu	37	12	6472772	6472772	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr12:6472772G>A	ENST00000358945.3	-	2	961	c.521C>T	c.(520-522)tCc>tTc	p.S174F	SCNN1A_ENST00000540037.1_5'UTR|SCNN1A_ENST00000228916.2_Missense_Mutation_p.S174F|SCNN1A_ENST00000360168.3_Missense_Mutation_p.S233F|SCNN1A_ENST00000538979.1_Intron|SCNN1A_ENST00000396966.2_Missense_Mutation_p.S174F|SCNN1A_ENST00000543768.1_Missense_Mutation_p.S197F			P37088	SCNNA_HUMAN	sodium channel, non-voltage-gated 1 alpha subunit	174					excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(2)|lung(6)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	27					Amiloride(DB00594)|Triamterene(DB00384)	ACGGCTGCGGGAGCCGGCCAC	0.672000													7	9					0	0	0.058154	0	0
SMOX	54498	broad.mit.edu	37	20	4163462	4163462	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr20:4163462G>A	ENST00000305958.4	+	5	1561	c.1336G>A	c.(1336-1338)Gag>Aag	p.E446K	SMOX_ENST00000339123.6_Missense_Mutation_p.E393K|SMOX_ENST00000346595.2_Intron|SMOX_ENST00000379460.2_Missense_Mutation_p.E446K|SMOX_ENST00000278795.3_Missense_Mutation_p.E393K	NM_175839.2	NP_787033.1	Q9NWM0	SMOX_HUMAN	spermine oxidase	446					polyamine biosynthetic process|xenobiotic metabolic process	cytosol|nucleus	polyamine oxidase activity			breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(7)|lung(5)|skin(2)|urinary_tract(1)	26					Spermine(DB00127)	GGCAGTGGCCGAGATCTGCAC	0.652000													27	32					0	0	0.125774	0	0
JADE1	79960	broad.mit.edu	37	4	129778584	129778584	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr4:129778584A>G	ENST00000226319.6	+	8	1236	c.956A>G	c.(955-957)aAt>aGt	p.N319S	PHF17_ENST00000452328.2_Missense_Mutation_p.N307S|PHF17_ENST00000413543.2_Missense_Mutation_p.N319S|PHF17_ENST00000511647.1_Missense_Mutation_p.N319S|PHF17_ENST00000512960.1_Missense_Mutation_p.N319S	NM_199320.2	NP_955352.1	Q6IE81	JADE1_HUMAN		319					apoptosis|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|negative regulation of cell growth|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	histone acetyltransferase complex|mitochondrion	protein binding|zinc ion binding			NS(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(10)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						AGCCTCTGCAATGAGAAGTTT	0.537000													106	7					0	0	0.139131	0	0
SERPINI2	5276	broad.mit.edu	37	3	167167184	167167184	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr3:167167184G>A	ENST00000476257.1	-	8	1269	c.971C>T	c.(970-972)tCt>tTt	p.S324F	SERPINI2_ENST00000461846.1_Missense_Mutation_p.S324F|SERPINI2_ENST00000264677.4_Missense_Mutation_p.S324F|SERPINI2_ENST00000471111.1_Missense_Mutation_p.S324F			O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin), member 2	324					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(20)|prostate(1)|skin(5)|urinary_tract(1)	41						ATACACTTCAGATGAATCTGG	0.303000													9	16					0	0	0.047766	0	0
GPRIN3	285513	broad.mit.edu	37	4	90170164	90170164	+	Silent	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr4:90170164C>T	ENST00000609438.1	-	2	1616	c.1098G>A	c.(1096-1098)ggG>ggA	p.G366G	GPRIN3_ENST00000333209.4_Silent_p.G366G	NM_198281.2	NP_938022.2	Q6ZVF9	GRIN3_HUMAN	GPRIN family member 3											breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(15)|ovary(5)|prostate(2)|skin(1)	36		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)		GTGTGTGGCTCCCACTGCTGT	0.582000													35	61					0	0	0.054565	0	0
EXD3	54932	broad.mit.edu	37	9	140250738	140250738	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr9:140250738G>A	ENST00000340951.4	-	8	934	c.739C>T	c.(739-741)Cgg>Tgg	p.R247W	EXD3_ENST00000342129.4_5'UTR	NM_017820.3	NP_060290.3	Q8N9H8	MUT7_HUMAN	exonuclease 3'-5' domain containing 3	247					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(2)	12						ACGCCGTACCGCTCCTGCAGA	0.662000													4	0					0	0	0.014758	0	0
ZNF337	26152	broad.mit.edu	37	20	25657348	25657348	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr20:25657348C>G	ENST00000376436.1	-	4	1115	c.576G>C	c.(574-576)aaG>aaC	p.K192N	RP4-694B14.5_ENST00000455791.1_RNA|RP4-694B14.5_ENST00000439498.1_RNA|RP4-694B14.5_ENST00000414393.1_RNA|ZNF337_ENST00000538750.1_Missense_Mutation_p.K160N|ZNF337_ENST00000252979.5_Missense_Mutation_p.K192N					zinc finger protein 337											breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(8)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						TTACCATCATCTTCCGGCTGA	0.433000													77	68					0	0	0.139131	0	0
SYBU	55638	broad.mit.edu	37	8	110598367	110598367	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr8:110598367G>A	ENST00000399066.3	-	3	1170	c.443C>T	c.(442-444)tCg>tTg	p.S148L	SYBU_ENST00000424158.2_Missense_Mutation_p.S156L|SYBU_ENST00000529690.1_Missense_Mutation_p.S21L|SYBU_ENST00000422135.1_Missense_Mutation_p.S151L|SYBU_ENST00000533895.1_Missense_Mutation_p.S150L|SYBU_ENST00000440310.1_Missense_Mutation_p.S151L|SYBU_ENST00000408889.3_Missense_Mutation_p.S32L|SYBU_ENST00000433638.1_Missense_Mutation_p.S151L|SYBU_ENST00000533171.1_Missense_Mutation_p.S151L|SYBU_ENST00000528331.1_Missense_Mutation_p.S32L|SYBU_ENST00000528647.1_Missense_Mutation_p.S150L|SYBU_ENST00000533065.1_Missense_Mutation_p.S32L|SYBU_ENST00000419099.1_Missense_Mutation_p.S150L|SYBU_ENST00000276646.9_Missense_Mutation_p.S151L|SYBU_ENST00000532779.1_Missense_Mutation_p.S83L|SYBU_ENST00000408908.2_Missense_Mutation_p.S151L|SYBU_ENST00000446070.2_Missense_Mutation_p.S150L	NM_001099756.1	NP_001093226.1	Q9NX95	SYBU_HUMAN	syntabulin (syntaxin-interacting)	151	Ser-rich.|Sufficient for interaction with KIF5B.					cytoplasmic membrane-bounded vesicle|cytoskeleton|Golgi membrane|integral to membrane				NS(1)|breast(4)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	30						TGTGCTGCTCGAGGAGCTAAA	0.527000													15	12					0	0	0.033300	0	0
KCNK1	3775	broad.mit.edu	37	1	233750079	233750079	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:233750079G>C	ENST00000366621.3	+	1	330	c.162G>C	c.(160-162)caG>caC	p.Q54H		NM_002245.3	NP_002236.1	O00180	KCNK1_HUMAN	potassium channel, subfamily K, member 1	54						voltage-gated potassium channel complex	inward rectifier potassium channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)	11		all_cancers(173;0.00217)|all_epithelial(177;0.121)|Prostate(94;0.122)|Acute lymphoblastic leukemia(190;0.175)			Ibutilide(DB00308)|Quinidine(DB00908)	TGCTGCGCCAGGAGCTGCGCA	0.637000													3	11					0	0	0.038147	0	0
TRPS1	7227	broad.mit.edu	37	8	116617033	116617033	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr8:116617033G>A	ENST00000395715.3	-	4	1740	c.1163C>T	c.(1162-1164)tCa>tTa	p.S388L	TRPS1_ENST00000220888.5_Missense_Mutation_p.S375L|TRPS1_ENST00000519674.1_Missense_Mutation_p.S375L|TRPS1_ENST00000519076.1_Missense_Mutation_p.S329L|TRPS1_ENST00000520276.1_Missense_Mutation_p.S379L	NM_001282902.1|NM_001282903.1|NM_014112.2	NP_001269831.1|NP_001269832.1|NP_054831.2	Q9UHF7	TRPS1_HUMAN	trichorhinophalangeal syndrome I	375					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(58)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	111	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			GTTTTTCTCTGAAGGTTTTGC	0.428000									Langer-Giedion syndrome				33	31					0	0	0.050027	0	0
KCNG2	26251	broad.mit.edu	37	18	77623955	77623955	+	Silent	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr18:77623955G>A	ENST00000316249.3	+	1	288	c.288G>A	c.(286-288)ccG>ccA	p.P96P		NM_012283.1	NP_036415.1	Q9UJ96	KCNG2_HUMAN	potassium voltage-gated channel, subfamily G, member 2	96					energy reserve metabolic process|regulation of heart contraction|regulation of insulin secretion	voltage-gated potassium channel complex	delayed rectifier potassium channel activity			breast(2)|endometrium(4)|lung(7)|skin(1)|upper_aerodigestive_tract(4)	18		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;6.92e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0244)		TGCGGGGCCCGTGCGCGCTGG	0.736000													17	5					0	0	0.043863	0	0
INPP5F	22876	broad.mit.edu	37	10	121586170	121586170	+	Silent	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr10:121586170C>T	ENST00000361976.2	+	20	2443	c.2277C>T	c.(2275-2277)atC>atT	p.I759I	INPP5F_ENST00000369080.3_Silent_p.I149I	NM_014937.3	NP_055752.1	Q9Y2H2	SAC2_HUMAN	inositol polyphosphate-5-phosphatase F	759							phosphoric ester hydrolase activity			breast(1)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(9)|lung(5)|ovary(5)|pancreas(1)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	42		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00205)|BRCA - Breast invasive adenocarcinoma(275;0.158)		ACGAAGACATCATTGGTATCA	0.353000													47	61					0	0	0.139131	0	0
TAS1R3	83756	broad.mit.edu	37	1	1267196	1267196	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:1267196G>C	ENST00000339381.5	+	2	402	c.370G>C	c.(370-372)Gac>Cac	p.D124H		NM_152228.1	NP_689414	Q7RTX0	TS1R3_HUMAN	taste receptor, type 1, member 3	124					detection of chemical stimulus involved in sensory perception of sweet taste|sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			kidney(2)|lung(8)|upper_aerodigestive_tract(1)|urinary_tract(1)	12	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.88e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.146)	Aspartame(DB00168)	AGGCAGCCGCGACATCGCCGC	0.647000													21	66					0	0	0.091800	0	0
NBAS	51594	broad.mit.edu	37	2	15493688	15493688	+	Silent	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr2:15493688G>A	ENST00000281513.5	-	34	4103	c.4078C>T	c.(4078-4080)Ctg>Ttg	p.L1360L	NBAS_ENST00000441750.1_Silent_p.L1240L	NM_015909.3	NP_056993.2	A2RRP1	NBAS_HUMAN	neuroblastoma amplified sequence	1360										NS(4)|breast(4)|central_nervous_system(3)|endometrium(6)|kidney(5)|large_intestine(12)|liver(1)|lung(54)|ovary(2)|pancreas(3)|prostate(9)|skin(6)|stomach(3)	112						TCTGTCTGCAGAGAGCTGCTA	0.458000													52	3					0	0	0.139131	0	0
NPR2	4882	broad.mit.edu	37	9	35801716	35801716	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr9:35801716G>A	ENST00000342694.2	+	8	1768	c.1513G>A	c.(1513-1515)Gag>Aag	p.E505K		NM_003995.3	NP_003986.2	P20594	ANPRB_HUMAN	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	505					intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(2)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	TGGCAACTCAGAGCGTTATCA	0.537000													50	52					0	0	0.139131	0	0
PRR12	57479	broad.mit.edu	37	19	50097789	50097789	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr19:50097789C>A	ENST00000418929.2	+	3	290	c.278C>A	c.(277-279)tCg>tAg	p.S93*		NM_020719.1	NP_065770.1	Q9ULL5	PRR12_HUMAN	proline rich 12	494	Pro-rich.						DNA binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|pancreas(1)|prostate(2)	11		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		AACCTTATCTCGGCCCTGGAA	0.677000													46	49					1.48734e-19	1.58088e-19	0.131918	1	0
NUDT7	283927	broad.mit.edu	37	16	77759476	77759476	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr16:77759476G>C	ENST00000268533.5	+	2	253	c.184G>C	c.(184-186)Gag>Cag	p.E62Q	NUDT7_ENST00000564085.1_Missense_Mutation_p.E62Q|NUDT7_ENST00000563839.1_Intron|NUDT7_ENST00000568787.1_Missense_Mutation_p.E62Q|NUDT7_ENST00000437314.3_Missense_Mutation_p.E62Q	NM_001105663.2	NP_001099133.1	P0C024	NUDT7_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 7	62	Nudix hydrolase.				nucleoside diphosphate metabolic process	peroxisome	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|magnesium ion binding|manganese ion binding			breast(1)|kidney(3)|large_intestine(6)|lung(6)|ovary(1)|skin(1)	18						CGTCCGGTCAGAGAAGGTAGG	0.428000													19	26					0	0	0.055883	0	0
PROX1	5629	broad.mit.edu	37	1	214170364	214170364	+	Silent	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:214170364G>A	ENST00000366958.4	+	2	1094	c.486G>A	c.(484-486)ctG>ctA	p.L162L	PROX1_ENST00000261454.4_Silent_p.L162L|PROX1_ENST00000498508.2_Silent_p.L162L|PROX1_ENST00000435016.1_Silent_p.L162L	NM_001270616.1	NP_001257545.1	Q92786	PROX1_HUMAN	prospero homeobox 1	162					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(3)|prostate(2)|skin(4)	47				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		ATGAGCACCTGAGAGCAAAGC	0.522000													44	54					0	0	0.131918	0	0
C6orf25	80739	broad.mit.edu	37	6	31692755	31692755	+	Silent	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr6:31692755C>T	ENST00000375809.3	+	6	660	c.649C>T	c.(649-651)Cta>Tta	p.L217L	C6orf25_ENST00000375810.4_3'UTR|C6orf25_ENST00000375805.2_Silent_p.L186L	NM_025260.3|NM_138272.2|NM_138277.2	NP_079536.2|NP_612116.1|NP_612121.1	O95866	G6B_HUMAN	chromosome 6 open reading frame 25	0						endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	heparin binding|receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(3)	9						AGAGCCTGCTCTATGCGGATC	0.547000													28	43					0	0	0.099896	0	0
EMC7	56851	broad.mit.edu	37	15	34382588	34382588	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr15:34382588G>C	ENST00000256545.4	-	3	533	c.425C>G	c.(424-426)tCt>tGt	p.S142C		NM_020154.2	NP_064539.1			ER membrane protein complex subunit 7																		TGGACCTGAAGATTTCATTTG	0.393000													30	2					0	0	0.125774	0	0
FAM135A	57579	broad.mit.edu	37	6	71191811	71191811	+	Silent	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr6:71191811C>T	ENST00000418814.2	+	10	1391	c.777C>T	c.(775-777)ttC>ttT	p.F259F	FAM135A_ENST00000361499.3_Silent_p.F259F|FAM135A_ENST00000370479.3_Silent_p.F216F|FAM135A_ENST00000457062.2_Silent_p.F216F|FAM135A_ENST00000505868.1_Silent_p.F259F|FAM135A_ENST00000505769.1_Silent_p.F259F	NM_001105531.2|NM_001162529.1	NP_001099001.1|NP_001156001.1	Q9P2D6	F135A_HUMAN	family with sequence similarity 135, member A	259										breast(2)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	38						ACAGCTACTTCATTACAGTAA	0.398000													30	42					0	0	0.134883	0	0
LRRC41	10489	broad.mit.edu	37	1	46744561	46744561	+	Silent	SNP	G	G	A	rs145793278	byFrequency	TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:46744561G>A	ENST00000343304.6	-	10	2700	c.2415C>T	c.(2413-2415)ttC>ttT	p.F805F	LRRC41_ENST00000472710.1_5'UTR	NM_006369.4	NP_006360.3	Q15345	LRC41_HUMAN	leucine rich repeat containing 41	805										breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(7)|ovary(3)|pancreas(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	28	Acute lymphoblastic leukemia(166;0.155)					CATAATCTGCGAAGGCCTGGG	0.607000													91	43					0	0	0.139131	0	0
HIVEP3	59269	broad.mit.edu	37	1	42048914	42048914	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:42048914C>G	ENST00000372584.1	-	3	2569	c.1555G>C	c.(1555-1557)Gaa>Caa	p.E519Q	HIVEP3_ENST00000429157.2_Missense_Mutation_p.E519Q|HIVEP3_ENST00000247584.5_Missense_Mutation_p.E519Q|HIVEP3_ENST00000372583.1_Missense_Mutation_p.E519Q	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	519	No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				AGTGATTGTTCAGGCTTGGTT	0.617000													52	128					0	0	0.139131	0	0
TAS2R39	259285	broad.mit.edu	37	7	142880769	142880769	+	Silent	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr7:142880769C>G	ENST00000446620.1	+	1	258	c.258C>G	c.(256-258)ctC>ctG	p.L86L		NM_176881.2	NP_795362.2	P59534	T2R39_HUMAN	taste receptor, type 2, member 39	86					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20	Melanoma(164;0.059)					GAATAGCTCTCCAAAGCCTCA	0.383000													62	62					0	0	0.139131	0	0
DNAH17	8632	broad.mit.edu	37	17	76562780	76562780	+	Silent	SNP	G	G	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr17:76562780G>T	ENST00000389840.5	-	11	1609	c.1485C>A	c.(1483-1485)atC>atA	p.I495I	DNAH17_ENST00000585328.1_Silent_p.I495I					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CTTGGATTTTGATCTCAAAAT	0.463000													6	11					2.0095e-06	2.04581e-06	0.029380	1	0
ARID4A	5926	broad.mit.edu	37	14	58827650	58827650	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr14:58827650G>C	ENST00000355431.3	+	19	2343	c.1970G>C	c.(1969-1971)aGa>aCa	p.R657T	ARID4A_ENST00000395168.3_Missense_Mutation_p.R657T|ARID4A_ENST00000431317.2_Missense_Mutation_p.R657T|ARID4A_ENST00000348476.3_Missense_Mutation_p.R657T	NM_002892.3	NP_002883.3	P29374	ARI4A_HUMAN	AT rich interactive domain 4A (RBP1-like)	657					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	transcriptional repressor complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(4)|endometrium(8)|kidney(2)|large_intestine(14)|lung(19)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						GACGAAAAGAGAGATGAGGAG	0.403000													48	45					0	0	0.139131	0	0
TTN	7273	broad.mit.edu	37	2	179412227	179412227	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr2:179412227A>G	ENST00000589042.1	-	339	94350	c.94126T>C	c.(94126-94128)Tac>Cac	p.Y31376H	TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.Y22436H|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.Y22311H|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.Y22503H|TTN_ENST00000591111.1_Missense_Mutation_p.Y29735H|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.Y28808H	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	29735	Fibronectin type-III 129.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATTCCATGTATTTTGTGAGA	0.393000													12	0					0	0	0.080935	0	0
PTPRO	5800	broad.mit.edu	37	12	15656841	15656841	+	Splice_Site	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr12:15656841G>C	ENST00000281171.4	+	6	1435		c.e6-1		PTPRO_ENST00000543886.1_Splice_Site|PTPRO_ENST00000348962.2_Splice_Site	NM_030667.2	NP_109592.1	Q16827	PTPRO_HUMAN	protein tyrosine phosphatase, receptor type, O							integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(2)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(11)|lung(30)|ovary(2)|prostate(1)|skin(17)|upper_aerodigestive_tract(1)	74		Hepatocellular(102;0.244)				ATATGATTTAGAGAACTTTAC	0.333000													6	19					0	0	0.029380	0	0
DNAH11	8701	broad.mit.edu	37	7	21856103	21856103	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr7:21856103G>A	ENST00000328843.6	+	65	10403	c.10372G>A	c.(10372-10374)Gaa>Aaa	p.E3458K	DNAH11_ENST00000409508.3_Missense_Mutation_p.E3451K			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3458					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						TCCACTAACCGAAGGCCTGGA	0.448000									Kartagener syndrome				14	9					0	0	0.119110	0	0
CCDC144CP	348254	broad.mit.edu	37	17	20239313	20239313	+	RNA	SNP	G	G	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr17:20239313G>T	ENST00000340196.4	+	0	737																											ATGGACACTGGGGTTGTACTT	0.423000													86	83					2.3666e-43	2.57206e-43	0.139131	1	0
DCAF12	25853	broad.mit.edu	37	9	34088357	34088357	+	Silent	SNP	G	G	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr9:34088357G>T	ENST00000361264.4	-	9	1694	c.1353C>A	c.(1351-1353)ctC>ctA	p.L451L	RP11-537H15.3_ENST00000448245.1_RNA	NM_015397.3	NP_056212.1	Q5T6F0	DCA12_HUMAN	DDB1 and CUL4 associated factor 12	451						centrosome|CUL4 RING ubiquitin ligase complex				breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)	11						ATTAACTCCAGAGCCCAGCAT	0.453000													60	92					3.37043e-27	3.63963e-27	0.139131	1	0
ING3	54556	broad.mit.edu	37	7	120591274	120591274	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr7:120591274G>A	ENST00000315870.5	+	2	233	c.85G>A	c.(85-87)Gac>Aac	p.D29N	ING3_ENST00000339121.5_Missense_Mutation_p.D29N|ING3_ENST00000445699.1_Missense_Mutation_p.D29N|ING3_ENST00000431467.1_Missense_Mutation_p.D14N	NM_019071.2	NP_061944.2	Q9NXR8	ING3_HUMAN	inhibitor of growth family, member 3	29					histone H2A acetylation|histone H4 acetylation|positive regulation of apoptosis|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|Piccolo NuA4 histone acetyltransferase complex	zinc ion binding			NS(1)|large_intestine(2)|lung(7)|ovary(1)|urinary_tract(1)	12	all_neural(327;0.117)					GCGCGAGATGGACCTGCAGGT	0.592000													69	58					0	0	0.139131	0	0
SH2D4A	63898	broad.mit.edu	37	8	19190596	19190596	+	Silent	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr8:19190596G>C	ENST00000265807.3	+	3	723	c.312G>C	c.(310-312)ctG>ctC	p.L104L	SH2D4A_ENST00000519207.1_Silent_p.L104L|SH2D4A_ENST00000518040.1_Silent_p.L59L	NM_001174160.1|NM_022071.3	NP_001167631.1|NP_071354.2	Q9H788	SH24A_HUMAN	SH2 domain containing 4A	104						cytoplasm|nucleus	protein binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|stomach(1)	16				Colorectal(111;0.0732)		GGGCCCGGCTGAAAGCAGAAC	0.468000													18	33					0	0	0.049695	0	0
RGPD3	653489	broad.mit.edu	37	2	107040707	107040707	+	Missense_Mutation	SNP	T	T	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr2:107040707T>A	ENST00000409886.3	-	20	3803	c.3716A>T	c.(3715-3717)aAt>aTt	p.N1239I	RGPD3_ENST00000304514.7_Missense_Mutation_p.N1239I	NM_001144013.1	NP_001137485.1	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	1239					intracellular transport		binding			breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						GTTTTCAGCATTGGGTTTTAT	0.418000													162	11					0	0	0.139131	0	0
GRIK4	2900	broad.mit.edu	37	11	120744829	120744829	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr11:120744829G>A	ENST00000527524.2	+	10	1248	c.961G>A	c.(961-963)Gaa>Aaa	p.E321K	RP11-640N11.2_ENST00000505153.2_RNA|GRIK4_ENST00000438375.2_Missense_Mutation_p.E321K	NM_001282470.1	NP_001269399.1	Q16099	GRIK4_HUMAN	glutamate receptor, ionotropic, kainate 4	321					glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(20)|liver(1)|lung(29)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	69		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	TGCGGTGCAGGAACTGAACCG	0.632000													18	24					0	0	0.049695	0	0
PEG3	5178	broad.mit.edu	37	19	57326977	57326977	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr19:57326977T>C	ENST00000326441.9	-	10	3196	c.2833A>G	c.(2833-2835)Agg>Ggg	p.R945G	ZIM2_ENST00000391708.3_Intron|ZIM2_ENST00000601070.1_Intron|PEG3_ENST00000598410.1_Missense_Mutation_p.R821G|ZIM2_ENST00000599935.1_Intron|ZIM2_ENST00000221722.5_Intron|ZIM2_ENST00000593711.1_Intron|PEG3_ENST00000423103.2_Missense_Mutation_p.R945G|PEG3_ENST00000593695.1_Missense_Mutation_p.R819G	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	945					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TCATTGCTCCTATGCTCAATG	0.463000													3	160					0	0	0.115264	0	0
SLC26A1	10861	broad.mit.edu	37	4	973208	973208	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr4:973208C>T	ENST00000398520.2	-	3	763	c.661G>A	c.(661-663)Gaa>Aaa	p.E221K		NM_134425.1	NP_602297.1	Q9H2B4	S26A1_HUMAN	solute carrier family 26 (anion exchanger), member 1	0						integral to membrane|plasma membrane	secondary active sulfate transmembrane transporter activity			central_nervous_system(1)|endometrium(4)|pancreas(1)|prostate(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			caagatctttcctcctcttcc	0.517000													10	13					0	0	0.058154	0	0
TMEM213	155006	broad.mit.edu	37	7	138487791	138487791	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr7:138487791G>T	ENST00000442682.2	+	3	454	c.301G>T	c.(301-303)Gag>Tag	p.E101*	TMEM213_ENST00000422794.2_Nonsense_Mutation_p.E151*|TMEM213_ENST00000397602.3_Nonsense_Mutation_p.E100*|TMEM213_ENST00000458494.1_Nonsense_Mutation_p.E77*|TMEM213_ENST00000413208.1_Intron	NM_001085429.1	NP_001078898.1	A2RRL7	TM213_HUMAN	transmembrane protein 213	101						integral to membrane				breast(1)|endometrium(3)|kidney(1)|lung(1)	6						GACTCCAGATGAGCCCAAGGA	0.562000													17	17					6.49762e-13	6.77838e-13	0.038395	1	0
TNN	63923	broad.mit.edu	37	1	175067473	175067473	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:175067473G>C	ENST00000239462.4	+	9	1974	c.1861G>C	c.(1861-1863)Gac>Cac	p.D621H		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	621	Fibronectin type-III 5.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		TCCAGATATTGACAGCCCCAA	0.498000													82	88					0	0	0.139131	0	0
NLRP14	338323	broad.mit.edu	37	11	7063621	7063621	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr11:7063621G>A	ENST00000299481.4	+	4	710	c.364G>A	c.(364-366)Gat>Aat	p.D122N		NM_176822.3	NP_789792.1	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	122					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			breast(3)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	21				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		TGACTTAGGTGATGGAACAGA	0.338000													25	36					0	0	0.091800	0	0
GPR162	27239	broad.mit.edu	37	12	6935995	6935995	+	Missense_Mutation	SNP	G	G	A	rs72270259		TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr12:6935995G>A	ENST00000311268.3	+	5	2180	c.1393G>A	c.(1393-1395)Gag>Aag	p.E465K	GPR162_ENST00000382315.3_Missense_Mutation_p.E161K|GPR162_ENST00000428545.2_Missense_Mutation_p.E181K	NM_019858.1	NP_062832.1	Q16538	GP162_HUMAN	G protein-coupled receptor 162	465						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(2)|skin(1)	18						GTTGGAGGACGAGGAGGACGA	0.652000													48	61					0	0	0.139131	0	0
PLA2G3	50487	broad.mit.edu	37	22	31536026	31536026	+	Silent	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr22:31536026C>T	ENST00000215885.3	-	1	567	c.315G>A	c.(313-315)caG>caA	p.Q105Q		NM_015715.3	NP_056530.2	Q9NZ20	PA2G3_HUMAN	phospholipase A2, group III	105					cilium morphogenesis|lipid catabolic process|phospholipid metabolic process	centriole|extracellular space|plasma membrane	calcium ion binding|calcium-dependent phospholipase A2 activity			large_intestine(1)|lung(10)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	18						CCAGTGCTCTCTGCAGCTCGG	0.647000													28	26					0	0	0.108266	0	0
PLEKHG2	64857	broad.mit.edu	37	19	39912864	39912864	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr19:39912864C>T	ENST00000425673.1	+	15	1851	c.1526C>T	c.(1525-1527)tCt>tTt	p.S509F	PLEKHG2_ENST00000409797.2_Missense_Mutation_p.S538F|PLEKHG2_ENST00000378550.1_Missense_Mutation_p.S538F|PLEKHG2_ENST00000458508.2_Missense_Mutation_p.S479F|PLEKHG2_ENST00000409794.3_Missense_Mutation_p.S538F			Q9H7P9	PKHG2_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	538					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(2)|liver(1)|lung(13)|pancreas(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	40	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CTGGACCCCTCTGGGACCTCA	0.587000													13	15					0	0	0.093190	0	0
FAM184A	79632	broad.mit.edu	37	6	119324104	119324104	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr6:119324104C>G	ENST00000338891.7	-	9	2491	c.2048G>C	c.(2047-2049)aGa>aCa	p.R683T	FAM184A_ENST00000368475.4_Missense_Mutation_p.R563T|FAM184A_ENST00000521531.1_Missense_Mutation_p.R683T|RP11-351A11.1_ENST00000518570.1_RNA|FAM184A_ENST00000352896.5_Missense_Mutation_p.R563T	NM_024581.4	NP_078857.5	Q8NB25	F184A_HUMAN	family with sequence similarity 184, member A	683										breast(2)|central_nervous_system(2)|endometrium(2)|kidney(5)|large_intestine(19)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(5)	52						CCATGAATCTCTTGCTGCATT	0.378000													29	65					0	0	0.116897	0	0
OR4D11	219986	broad.mit.edu	37	11	59271954	59271954	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr11:59271954G>C	ENST00000313253.1	+	1	906	c.906G>C	c.(904-906)aaG>aaC	p.K302N		NM_001004706.1	NP_001004706.1	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D, member 11	302					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29						GAAGACTGAAGAGAAGACTCG	0.532000													21	27					0	0	0.055883	0	0
RRH	10692	broad.mit.edu	37	4	110756555	110756555	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr4:110756555G>T	ENST00000317735.4	+	3	365	c.331G>T	c.(331-333)Gca>Tca	p.A111S		NM_006583.2	NP_006574.1	O14718	OPSX_HUMAN	retinal pigment epithelium-derived rhodopsin homolog	111					phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|pancreas(1)	12		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00109)		TTTTGGAATGGCAAGCATTGG	0.398000													32	2					2.47316e-13	2.58801e-13	0.059317	1	0
SYT12	91683	broad.mit.edu	37	11	66812099	66812099	+	Silent	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr11:66812099C>T	ENST00000393946.2	+	9	2035	c.873C>T	c.(871-873)ctC>ctT	p.L291L	SYT12_ENST00000525457.1_Silent_p.L291L|SYT12_ENST00000527043.1_Silent_p.L291L			Q8IV01	SYT12_HUMAN	synaptotagmin XII	291	C2 2.					cell junction|integral to membrane|synaptic vesicle membrane				NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|urinary_tract(1)	20						TGCTCTCCCTCAGCTACCTCC	0.652000													45	39					0	0	0.139131	0	0
CORIN	10699	broad.mit.edu	37	4	47645189	47645189	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr4:47645189G>T	ENST00000273857.4	-	15	2041	c.2042C>A	c.(2041-2043)tCa>tAa	p.S681*	CORIN_ENST00000504584.1_Nonsense_Mutation_p.S644*|CORIN_ENST00000508498.1_Nonsense_Mutation_p.S542*|CORIN_ENST00000505909.1_Nonsense_Mutation_p.S644*|CORIN_ENST00000502252.1_Nonsense_Mutation_p.S614*	NM_006587.2	NP_006578.2	Q9Y5Q5	CORIN_HUMAN	corin, serine peptidase	681	LDL-receptor class A 7.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						TGAACTGTCTGAGCAGTCGGC	0.493000													23	34					5.35356e-11	5.48334e-11	0.076483	1	0
POTEA	340441	broad.mit.edu	37	8	43197037	43197037	+	RNA	SNP	T	T	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr8:43197037T>C	ENST00000522175.2	+	0	1067							Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A											breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(27)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						AAAAGAAATCTAATGAAAAGA	0.214000													8	14					0	0	0.047766	0	0
HIST1H2AJ	8331	broad.mit.edu	37	6	27782430	27782430	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr6:27782430C>A	ENST00000333151.3	-	1	177	c.89G>T	c.(88-90)cGa>cTa	p.R30L		NM_021066.2	NP_066544.1	Q99878	H2A1J_HUMAN	histone cluster 1, H2aj	30					nucleosome assembly	nucleosome|nucleus	DNA binding	p.R30Q(1)		NS(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(2)	11						GCGATGCACTCGGCCTACGGG	0.652000													19	18					2.21704e-12	2.29864e-12	0.076483	1	0
TXNDC5	81567	broad.mit.edu	37	6	7883499	7883499	+	Splice_Site	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr6:7883499C>T	ENST00000539054.1	-	10	960	c.961G>A	c.(961-963)Gta>Ata	p.V321I	TXNDC5_ENST00000379757.4_Splice_Site_p.V393I|TXNDC5_ENST00000473453.1_Splice_Site_p.V285I|BLOC1S5-TXNDC5_ENST00000439343.2_3'UTR			Q8NBS9	TXND5_HUMAN	thioredoxin domain containing 5 (endoplasmic reticulum)		Thioredoxin 3.				anti-apoptosis|cell redox homeostasis|cellular membrane organization|glycerol ether metabolic process|post-Golgi vesicle-mediated transport	endoplasmic reticulum lumen|lysosomal lumen	electron carrier activity|isomerase activity|protein disulfide oxidoreductase activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(6)|prostate(1)|skin(2)	22	Ovarian(93;0.0398)					TAGCCTCGTACCTTAAAACAA	0.463000													30	36					0	0	0.144211	0	0
UTRN	7402	broad.mit.edu	37	6	144814560	144814560	+	Silent	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr6:144814560C>T	ENST00000367545.3	+	32	4561	c.4561C>T	c.(4561-4563)Ctg>Ttg	p.L1521L		NM_007124.2	NP_009055.2	P46939	UTRO_HUMAN	utrophin	1521	Interaction with SYNM.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|cervix(2)|endometrium(21)|kidney(10)|large_intestine(29)|lung(56)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	148		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		GCTGACTTCCCTGAAGGTTCT	0.478000													31	43					0	0	0.045705	0	0
TRIM62	55223	broad.mit.edu	37	1	33646983	33646983	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:33646983G>C	ENST00000291416.5	-	1	284	c.51C>G	c.(49-51)atC>atG	p.I17M	TRIM62_ENST00000485148.1_5'UTR	NM_018207.2	NP_060677.2	Q9BVG3	TRI62_HUMAN	tripartite motif containing 62	17						intracellular	zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	15		Myeloproliferative disorder(586;0.0393)				GGTCCTGGTAGATGCTCAGGC	0.711000													21	15					0	0	0.076483	0	0
CREBBP	1387	broad.mit.edu	37	16	3786706	3786706	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr16:3786706C>T	ENST00000262367.5	-	27	5314	c.4505G>A	c.(4504-4506)tGg>tAg	p.W1502*	CREBBP_ENST00000382070.3_Nonsense_Mutation_p.W1464*	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	1502	Interaction with TRERF1.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		CTTTTTGTACCACTCCTGCAG	0.512000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						98	7					0	0	0.139131	0	0
SEPT5	5413	broad.mit.edu	37	22	19709787	19709787	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr22:19709787G>A	ENST00000438754.2	+	10	1274	c.994G>A	c.(994-996)Gag>Aag	p.E332K	SEPT5_ENST00000383045.3_Silent_p.E335E|SEPT5_ENST00000455784.2_Silent_p.E326E|SEPT5_ENST00000406395.1_Missense_Mutation_p.E323K	NM_001009939.2	NP_001009939.1	Q99719	SEPT5_HUMAN	septin 5	0					cell cycle|cytokinesis|regulation of exocytosis|synaptic vesicle targeting	plasma membrane|septin complex|synaptic vesicle	GTP binding|GTPase activity|protein binding|structural molecule activity			lung(1)|upper_aerodigestive_tract(1)	2	Colorectal(54;0.0993)					GCCGCATGGAGAGCCCCATCC	0.716000													6	12					0	0	0.021553	0	0
TRAF3IP3	80342	broad.mit.edu	37	1	209936882	209936882	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:209936882C>G	ENST00000367024.1	+	8	1168	c.652C>G	c.(652-654)Ctc>Gtc	p.L218V	TRAF3IP3_ENST00000010338.4_Missense_Mutation_p.L198V|TRAF3IP3_ENST00000367025.3_Missense_Mutation_p.L218V|TRAF3IP3_ENST00000400959.3_Missense_Mutation_p.L198V|TRAF3IP3_ENST00000367026.3_Missense_Mutation_p.L198V			Q9Y228	T3JAM_HUMAN	TRAF3 interacting protein 3	218						integral to membrane	protein binding			breast(2)|endometrium(1)|large_intestine(8)|lung(15)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32				OV - Ovarian serous cystadenocarcinoma(81;0.045)		AATGGTGATTCTCCAAGACCT	0.498000													26	20					0	0	0.099896	0	0
PTEN	5728	broad.mit.edu	37	10	89717708	89717708	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr10:89717708C>T	ENST00000371953.3	+	7	2090	c.733C>T	c.(733-735)Cag>Tag	p.Q245*	PTEN_ENST00000472832.1_3'UTR	NM_000314.4	NP_000305.3	P60484	PTEN_HUMAN	phosphatase and tensin homolog	245	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.0?(37)|p.Q245*(8)|p.R55fs*1(5)|p.N212fs*1(2)|p.Y27fs*1(2)|p.G165_*404del(1)|p.?(1)|p.F243fs*9(1)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TGAGTTCCCTCAGCCGTTACC	0.418000		31	"""D, Mis, N, F, S"""		"""glioma,  prostate, endometrial"""	"""harmartoma, glioma,  prostate, endometrial"""			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			34	2					0	0	0.069456	0	0
ARID1A	8289	broad.mit.edu	37	1	27059264	27059264	+	Nonsense_Mutation	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:27059264C>G	ENST00000324856.7	+	4	2272	c.1901C>G	c.(1900-1902)tCa>tGa	p.S634*	ARID1A_ENST00000374152.2_Nonsense_Mutation_p.S251*|ARID1A_ENST00000457599.2_Nonsense_Mutation_p.S634*	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	634					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		AGCCTTCAGTCAAGACCCTCC	0.483000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								55	2					0	0	0.139131	0	0
RECK	8434	broad.mit.edu	37	9	36112348	36112348	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr9:36112348G>C	ENST00000377966.3	+	16	2501	c.1935G>C	c.(1933-1935)caG>caC	p.Q645H		NM_021111.2	NP_066934.1	O95980	RECK_HUMAN	reversion-inducing-cysteine-rich protein with kazal motifs	645	Kazal-like 1.					anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	32			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)			TATGTGGGCAGAATGGGCGCA	0.498000													24	29					0	0	0.076483	0	0
TMEM61	199964	broad.mit.edu	37	1	55452105	55452105	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:55452105G>C	ENST00000371268.3	+	2	625	c.351G>C	c.(349-351)gaG>gaC	p.E117D	RP11-12C17.2_ENST00000436960.1_RNA	NM_182532.1	NP_872338.1	Q8N0U2	TMM61_HUMAN	transmembrane protein 61	117						integral to membrane				endometrium(1)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	4						AGTCCTCAGAGAAGGAGAGCT	0.627000													124	64					0	0	0.139131	0	0
CARM1	10498	broad.mit.edu	37	19	11018792	11018792	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr19:11018792G>A	ENST00000327064.4	+	3	614	c.424G>A	c.(424-426)Gag>Aag	p.E142K	CARM1_ENST00000344150.4_Missense_Mutation_p.E142K	NM_199141.1	NP_954592.1	Q86X55	CARM1_HUMAN	coactivator-associated arginine methyltransferase 1	142					cellular lipid metabolic process|histone H3-R2 methylation|interspecies interaction between organisms|pathogenesis|positive regulation of fat cell differentiation|regulation of estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleoplasm	beta-catenin binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-R17 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein-arginine omega-N asymmetric methyltransferase activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|urinary_tract(1)	13						CGAGCGGACGGAGGAGTCTTC	0.637000													47	66					0	0	0.139131	0	0
PAPLN	89932	broad.mit.edu	37	14	73712862	73712862	+	Silent	SNP	C	C	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr14:73712862C>A	ENST00000427855.1	+	5	415	c.313C>A	c.(313-315)Cgg>Agg	p.R105R	PAPLN_ENST00000555445.1_Silent_p.R105R|PAPLN_ENST00000340738.5_Silent_p.R105R|PAPLN_ENST00000554301.1_Silent_p.R105R|PAPLN_ENST00000381166.3_Silent_p.R105R			O95428	PPN_HUMAN	papilin, proteoglycan-like sulfated glycoprotein	105						proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(3)|pancreas(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(3)	42				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.0468)		GCGGCGGTATCGGTGGCTGCC	0.667000													8	7					0.0381472	0.0382604	0.038147	1	0
DTX3L	151636	broad.mit.edu	37	3	122288708	122288708	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr3:122288708C>T	ENST00000296161.4	+	3	1961	c.1772C>T	c.(1771-1773)tCa>tTa	p.S591L	DTX3L_ENST00000383661.3_Intron	NM_138287.3	NP_612144.1	Q8TDB6	DTX3L_HUMAN	deltex 3-like (Drosophila)	591					histone monoubiquitination|response to DNA damage stimulus	cytoplasm|nucleus	histone binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	24				GBM - Glioblastoma multiforme(114;0.0459)		AAAGCCATGTCATATAAGCCA	0.433000													52	66					0	0	0.139131	0	0
SLC35F3	148641	broad.mit.edu	37	1	234452395	234452395	+	Silent	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:234452395C>T	ENST00000366618.3	+	5	1021	c.876C>T	c.(874-876)taC>taT	p.Y292Y	SLC35F3_ENST00000366617.3_Silent_p.Y223Y	NM_173508.2	NP_775779.1	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	223					transport	integral to membrane				breast(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|urinary_tract(1)	32	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			TGATGACCTACGCTGATGGCT	0.587000													145	158					0	0	0.139131	0	0
ARHGAP8	23779	broad.mit.edu	37	22	45241212	45241212	+	Silent	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr22:45241212G>C	ENST00000517296.3	+	13	1290	c.1290G>C	c.(1288-1290)ctG>ctC	p.L430L	ARHGAP8_ENST00000336963.4_Silent_p.L220L|ARHGAP8_ENST00000356099.6_Silent_p.L220L|PRR5-ARHGAP8_ENST00000361473.5_Silent_p.L351L|ARHGAP8_ENST00000389774.2_Silent_p.L251L|ARHGAP8_ENST00000389773.5_Silent_p.L342L|PRR5-ARHGAP8_ENST00000352766.7_Silent_p.L430L					Rho GTPase activating protein 8											breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(9)|prostate(1)|skin(7)	29		all_neural(38;0.00409)|Ovarian(80;0.00976)|Glioma(61;0.0649)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0204)		TGACGTACCTGAGAGAGAAAG	0.537000													34	45					0	0	0.050027	0	0
TNFRSF10C	8794	broad.mit.edu	37	8	22974541	22974541	+	Silent	SNP	T	T	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr8:22974541T>C	ENST00000356864.3	+	5	1309	c.777T>C	c.(775-777)gtT>gtC	p.V259V	TNFRSF10C_ENST00000540813.1_Silent_p.V157V	NM_003841.3	NP_003832	O14798	TR10C_HUMAN	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain	259					apoptosis	anchored to membrane|integral to plasma membrane	TRAIL binding|transmembrane receptor activity			endometrium(1)|large_intestine(6)|lung(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	15		Prostate(55;0.0421)|Breast(100;0.067)		Colorectal(74;0.0147)|COAD - Colon adenocarcinoma(73;0.0612)		TTGTGTTTGTTTGAAAGACTT	0.522000													58	73					0	0	0.139131	0	0
MROH5	389690	broad.mit.edu	37	8	142446094	142446094	+	RNA	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr8:142446094C>G	ENST00000606664.1	+	0	1450				MROH5_ENST00000430863.1_RNA																							GCAGGCCGCTCAGCTCCCTGT	0.682000													25	25					0	0	0.076483	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140711156	140711156	+	Nonsense_Mutation	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr5:140711156C>G	ENST00000517417.1	+	1	905	c.905C>G	c.(904-906)tCa>tGa	p.S302*	PCDHGA1_ENST00000378105.3_Nonsense_Mutation_p.S302*	NM_018912.2	NP_061735.1														breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|lung(32)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGAGAAATATCAAATAAAGAA	0.418000													18	25					0	0	0.038395	0	0
HELQ	113510	broad.mit.edu	37	4	84376714	84376714	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr4:84376714C>A	ENST00000295488.3	-	1	295	c.133G>T	c.(133-135)Gaa>Taa	p.E45*	HELQ_ENST00000440639.2_5'UTR|HELQ_ENST00000510985.1_Nonsense_Mutation_p.E45*	NM_133636.2	NP_598375	Q8TDG4	HELQ_HUMAN	helicase, POLQ-like	45							ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(10)|lung(17)|ovary(2)|skin(2)	38						GCCACCATTTCCTCCTCCTCT	0.602000								Other identified genes with known or suspected DNA repair function			OREG0016254	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	87	96					3.37217e-29	3.65318e-29	0.139131	1	0
OR4K2	390431	broad.mit.edu	37	14	20344666	20344666	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr14:20344666G>C	ENST00000298642.2	+	1	276	c.240G>C	c.(238-240)aaG>aaC	p.K80N		NM_001005501.1	NP_001005501.1	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K, member 2	80					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.K80N(1)		NS(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(16)|ovary(2)|skin(9)|upper_aerodigestive_tract(2)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CCACCCCAAAGATGATTACAG	0.413000													61	180					0	0	0.139131	0	0
HSPG2	3339	broad.mit.edu	37	1	22186152	22186152	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:22186152G>C	ENST00000374695.3	-	42	5279	c.5200C>G	c.(5200-5202)Ccc>Gcc	p.P1734A		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	1734	Ig-like C2-type 2.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	TGGACGCTGGGGAAGTGGAGC	0.582000													4	17					0	0	0.021553	0	0
ZNF615	284370	broad.mit.edu	37	19	52498067	52498067	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr19:52498067G>C	ENST00000602063.1	-	6	611	c.262C>G	c.(262-264)Ctg>Gtg	p.L88V	ZNF615_ENST00000376716.5_Missense_Mutation_p.L88V|ZNF615_ENST00000598071.1_Missense_Mutation_p.L99V|ZNF615_ENST00000594083.1_Missense_Mutation_p.L99V|ZNF615_ENST00000391795.3_Missense_Mutation_p.L93V			Q8N8J6	ZN615_HUMAN	zinc finger protein 615	88					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(5)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	42		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		TGATGCTGCAGAGGATCATCA	0.318000													26	27					0	0	0.108266	0	0
KDM6A	7403	broad.mit.edu	37	X	44922802	44922802	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chrX:44922802C>T	ENST00000377967.4	+	16	1704	c.1663C>T	c.(1663-1665)Cag>Tag	p.Q555*	KDM6A_ENST00000543216.1_Nonsense_Mutation_p.Q476*|KDM6A_ENST00000382899.4_Nonsense_Mutation_p.Q562*|KDM6A_ENST00000536777.1_Nonsense_Mutation_p.Q510*	NM_021140.2	NP_066963.2	O15550	KDM6A_HUMAN	lysine (K)-specific demethylase 6A	555					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0?(6)|p.0(2)|p.Q555*(2)		NS(1)|breast(7)|central_nervous_system(27)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(24)|kidney(24)|large_intestine(9)|liver(1)|lung(21)|oesophagus(11)|pancreas(2)|prostate(5)|skin(1)|soft_tissue(1)|urinary_tract(29)	170						TAGCGTCTCTCAGCCTGGAGT	0.567000			"""D, N, F, S"""		"""renal, oesophageal SCC, MM"""								25	0					0	0	0.091800	0	0
NPR2	4882	broad.mit.edu	37	9	35800738	35800738	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr9:35800738G>C	ENST00000342694.2	+	6	1506	c.1251G>C	c.(1249-1251)caG>caC	p.Q417H		NM_003995.3	NP_003986.2	P20594	ANPRB_HUMAN	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	417					intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(2)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	CTGAGAAGCAGATTTGGTGGA	0.607000													22	25					0	0	0.062417	0	0
LRRC7	57554	broad.mit.edu	37	1	70484501	70484501	+	Splice_Site	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:70484501G>A	ENST00000310961.5	+	16	1739	c.1321G>A	c.(1321-1323)Gat>Aat	p.D441N	LRRC7_ENST00000035383.5_Splice_Site_p.D436N|RP11-181B18.1_ENST00000414132.1_RNA|LRRC7_ENST00000415775.2_5'UTR			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	436						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						TGGTGATGAAGGTAAATTGTC	0.393000													19	23					0	0	0.055883	0	0
SETD6	79918	broad.mit.edu	37	16	58552697	58552697	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr16:58552697G>A	ENST00000394266.4	+	9	1035	c.979G>A	c.(979-981)Gaa>Aaa	p.E327K	SETD6_ENST00000310682.2_Missense_Mutation_p.E372K|SETD6_ENST00000219315.4_Missense_Mutation_p.E396K			Q8TBK2	SETD6_HUMAN	SET domain containing 6	396					negative regulation of NF-kappaB transcription factor activity|peptidyl-lysine monomethylation|regulation of inflammatory response	nucleus	NF-kappaB binding|protein-lysine N-methyltransferase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|skin(1)	7						TGATAAAAGGGAAGAGGGCAG	0.478000													27	39					0	0	0.108266	0	0
ABCC5	10057	broad.mit.edu	37	3	183643381	183643381	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr3:183643381G>C	ENST00000334444.6	-	29	4414	c.4174C>G	c.(4174-4176)Cta>Gta	p.L1392V	ABCC5_ENST00000265586.6_Missense_Mutation_p.L1349V	NM_005688.2	NP_005679.2	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	1392	ABC transporter 2.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TCGGAGCCTAGAACCGTGTGC	0.547000													33	33					0	0	0.054565	0	0
BRCA1	672	broad.mit.edu	37	17	41243707	41243707	+	Nonsense_Mutation	SNP	G	G	A	rs80356866		TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr17:41243707G>A	ENST00000309486.4	-	9	3980	c.2953C>T	c.(2953-2955)Cag>Tag	p.Q985*	BRCA1_ENST00000354071.3_Nonsense_Mutation_p.Q1281*|BRCA1_ENST00000468300.1_Intron|BRCA1_ENST00000351666.3_Intron|BRCA1_ENST00000591849.1_Intron|BRCA1_ENST00000357654.3_Nonsense_Mutation_p.Q1281*|BRCA1_ENST00000586385.1_Intron|BRCA1_ENST00000493795.1_Nonsense_Mutation_p.Q1234*|BRCA1_ENST00000491747.2_Intron|BRCA1_ENST00000591534.1_Intron|BRCA1_ENST00000346315.3_Nonsense_Mutation_p.Q1281*|BRCA1_ENST00000352993.3_Intron|BRCA1_ENST00000471181.2_Nonsense_Mutation_p.Q1281*	NM_007297.3	NP_009228.2	P38398	BRCA1_HUMAN	breast cancer 1, early onset	1281					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(30)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(28)|ovary(36)|skin(2)|stomach(4)|urinary_tract(2)	120		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		TGATGTTCCTGAGATGCCTTT	0.398000			"""D, Mis, N, F, S"""		ovarian	"""breast, ovarian"""		Homologous recombination	Hereditary Breast-Ovarian Cancer, BRCA1 type	TCGA Ovarian(2;0.000030)			66	79					0	0	0.139131	0	0
SEPT8	23176	broad.mit.edu	37	5	132099510	132099510	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr5:132099510G>A	ENST00000296873.7	-	4	705	c.422C>T	c.(421-423)tCg>tTg	p.S141L	SEPT8_ENST00000378701.1_Missense_Mutation_p.S139L|SEPT8_ENST00000378721.4_Missense_Mutation_p.S139L|SEPT8_ENST00000378706.1_Missense_Mutation_p.S141L|SEPT8_ENST00000378719.2_Missense_Mutation_p.S141L|SEPT8_ENST00000458488.2_Missense_Mutation_p.S141L|SEPT8_ENST00000448933.1_Missense_Mutation_p.S81L|SEPT8_ENST00000378699.2_Missense_Mutation_p.S81L	NM_001098812.1|NM_015146.1	NP_001092282.1|NP_055961.1	Q92599	SEPT8_HUMAN	septin 8	141					cell cycle	septin complex	GTP binding|protein binding		SEPT8/AFF4(2)	kidney(2)|lung(5)|ovary(2)|skin(1)|urinary_tract(1)	11		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GTCGAAGAGCGAGCGGCGGAT	0.507000											OREG0003468	type=REGULATORY REGION|Gene=LOC540614|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	88	93					0	0	0.139131	0	0
APOBEC3D	140564	broad.mit.edu	37	22	39428283	39428283	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr22:39428283C>T	ENST00000216099.8	+	7	1530	c.1123C>T	c.(1123-1125)Cga>Tga	p.R375*	APOBEC3D_ENST00000427494.2_Nonsense_Mutation_p.R191*|APOBEC3D_ENST00000381568.4_Nonsense_Mutation_p.R375*	NM_152426.3	NP_689639.2	Q96AK3	ABC3D_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D						negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(2)	11	Melanoma(58;0.04)					AACCAACTTTCGACTTCTGAA	0.478000													57	64					0	0	0.139131	0	0
GAK	2580	broad.mit.edu	37	4	875823	875823	+	Silent	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr4:875823C>G	ENST00000314167.4	-	15	1643	c.1533G>C	c.(1531-1533)ggG>ggC	p.G511G	GAK_ENST00000511163.1_Silent_p.G432G	NM_005255.2	NP_005246.2	O14976	GAK_HUMAN	cyclin G associated kinase	511	Phosphatase tensin-type.				cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(16)|skin(7)|urinary_tract(2)	39				Colorectal(103;0.219)		ACGCGGCTCTCCCGTCCTAGG	0.657000													8	3					0	0	0.038147	0	0
VSX2	338917	broad.mit.edu	37	14	74711893	74711893	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr14:74711893G>C	ENST00000261980.2	+	3	571	c.481G>C	c.(481-483)Gag>Cag	p.E161Q		NM_182894.2	NP_878314.1	P58304	VSX2_HUMAN	visual system homeobox 2	161					multicellular organismal development|response to stimulus|visual perception	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	7				BRCA - Breast invasive adenocarcinoma(234;0.00154)		CTACCAGCTAGAGGAGCTGGA	0.542000													21	24					0	0	0.055883	0	0
TAS1R3	83756	broad.mit.edu	37	1	1267862	1267862	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:1267862G>C	ENST00000339381.5	+	3	983	c.951G>C	c.(949-951)caG>caC	p.Q317H		NM_152228.1	NP_689414	Q7RTX0	TS1R3_HUMAN	taste receptor, type 1, member 3	317					detection of chemical stimulus involved in sensory perception of sweet taste|sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			kidney(2)|lung(8)|upper_aerodigestive_tract(1)|urinary_tract(1)	12	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.88e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.146)	Aspartame(DB00168)	GCATGGCCCAGATGGGCACGG	0.667000													13	31					0	0	0.093190	0	0
MALAT1	378938	broad.mit.edu	37	11	65271750	65271750	+	RNA	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr11:65271750G>A	ENST00000534336.1	+	0	6518					NR_002819.2																						GGAGGGATGGGAGGAGGGGGT	0.428000													16	13					0	0	0.033300	0	0
TLR8	51311	broad.mit.edu	37	X	12940174	12940174	+	Silent	SNP	T	T	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chrX:12940174T>C	ENST00000218032.6	+	2	3102	c.3015T>C	c.(3013-3015)ccT>ccC	p.P1005P	TLR8_ENST00000311912.5_Silent_p.P1023P	NM_138636.4	NP_619542.1	Q9NR97	TLR8_HUMAN	toll-like receptor 8	1005	TIR.				cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						TCCAGTGGCCTGACAACCCGA	0.443000													4	84					0	0	0.009096	0	0
UBXN1	51035	broad.mit.edu	37	11	62444039	62444039	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr11:62444039G>C	ENST00000533000.1	-	4	298	c.298C>G	c.(298-300)Ctg>Gtg	p.L100V	UBXN1_ENST00000294119.2_3'UTR|UBXN1_ENST00000301935.5_3'UTR|UBXN1_ENST00000529640.1_3'UTR			Q04323	UBXN1_HUMAN	UBX domain protein 1	0	Interaction with BRCA1.				negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process	cytoplasm	ATPase binding|K6-linked polyubiquitin binding			endometrium(5)|lung(12)	17						AGGGGTCACAGAGGGACAATG	0.493000													3	7					0	0	0.115264	0	0
NWD1	284434	broad.mit.edu	37	19	16918490	16918490	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr19:16918490G>A	ENST00000524140.2	+	18	4248	c.3830G>A	c.(3829-3831)gGg>gAg	p.G1277E	NWD1_ENST00000549814.1_Missense_Mutation_p.G1235E|NWD1_ENST00000523826.1_Missense_Mutation_p.G1071E|NWD1_ENST00000339803.6_Missense_Mutation_p.G1142E|NWD1_ENST00000379808.3_Missense_Mutation_p.G1277E|NWD1_ENST00000552788.1_Missense_Mutation_p.G1277E	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	1277							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						CTCGTGTCGGGGGTCGTCCTT	0.587000													46	36					0	0	0.124865	0	0
COL8A1	1295	broad.mit.edu	37	3	99513684	99513684	+	Silent	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr3:99513684C>T	ENST00000261037.3	+	5	1319	c.939C>T	c.(937-939)ccC>ccT	p.P313P	COL8A1_ENST00000273342.4_Silent_p.P313P	NM_001850.4	NP_001841.2	P27658	CO8A1_HUMAN	collagen, type VIII, alpha 1	313	Triple-helical region (COL1).				angiogenesis|cell adhesion	basement membrane|collagen type VIII				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(15)|skin(5)|upper_aerodigestive_tract(1)	27						CTGGGATACCCGGAATTGGAA	0.662000													15	32					0	0	0.119110	0	0
MAP3K2	10746	broad.mit.edu	37	2	128079675	128079675	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr2:128079675C>T	ENST00000409947.1	-	12	1274	c.992G>A	c.(991-993)aGt>aAt	p.S331N	MAP3K2_ENST00000344908.5_Missense_Mutation_p.S331N			Q9Y2U5	M3K2_HUMAN	mitogen-activated protein kinase kinase kinase 2	331					activation of JUN kinase activity|cellular response to mechanical stimulus	nucleus	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein kinase binding			central_nervous_system(1)|large_intestine(1)|lung(3)|ovary(2)	7	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0706)		GTCTATGTCACTTCCCCTTCT	0.423000													17	0					0	0	0.033300	0	0
SIGLEC7	27036	broad.mit.edu	37	19	51647699	51647699	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr19:51647699C>A	ENST00000317643.6	+	2	539	c.470C>A	c.(469-471)aCc>aAc	p.T157N	SIGLEC7_ENST00000600577.1_Intron|SIGLEC7_ENST00000305628.7_Intron	NM_014385.2	NP_055200.1	Q9Y286	SIGL7_HUMAN	sialic acid binding Ig-like lectin 7	157	Ig-like C2-type 1.				cell adhesion	integral to plasma membrane	receptor activity|sugar binding			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(11)|skin(2)|stomach(1)	29		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000836)|OV - Ovarian serous cystadenocarcinoma(262;0.00297)		ATCCCCGGTACCCTGGAGTCT	0.612000													90	119					1.59228e-47	1.7361e-47	0.139131	1	0
KLHL25	64410	broad.mit.edu	37	15	86311830	86311830	+	Silent	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr15:86311830C>T	ENST00000337975.5	-	2	1486	c.1212G>A	c.(1210-1212)ccG>ccA	p.P404P	KLHL25_ENST00000536947.1_Silent_p.P404P|KLHL25_ENST00000559131.1_Intron	NM_022480.3	NP_071925.2	Q9H0H3	ENC2_HUMAN	kelch-like family member 25	404						cytoplasm				breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	25						AAGGCGAGGCCGGGAAGACCC	0.622000													29	2					0	0	0.134883	0	0
NPR2	4882	broad.mit.edu	37	9	35802245	35802245	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr9:35802245G>C	ENST00000342694.2	+	10	1930	c.1675G>C	c.(1675-1677)Gag>Cag	p.E559Q		NM_003995.3	NP_003986.2	P20594	ANPRB_HUMAN	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	559	Protein kinase.				intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(2)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	GAAGCGCATTGAGCTGACCCG	0.433000													41	55					0	0	0.139131	0	0
AATK	9625	broad.mit.edu	37	17	79094710	79094710	+	Nonsense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr17:79094710G>C	ENST00000326724.4	-	11	3050	c.3026C>G	c.(3025-3027)tCa>tGa	p.S1009*	AATK_ENST00000417379.1_Nonsense_Mutation_p.S906*	NM_001080395.2	NP_001073864.2	Q6ZMQ8	LMTK1_HUMAN	apoptosis-associated tyrosine kinase	1009						integral to membrane|mitochondrion|perinuclear region of cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(2)|kidney(2)|lung(8)|ovary(3)|prostate(1)|stomach(4)|upper_aerodigestive_tract(1)	21	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			CTCTGGGCCTGAGGTGGCCTC	0.667000													6	8					0	0	0.021553	0	0
SEC63	11231	broad.mit.edu	37	6	108215079	108215079	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr6:108215079G>C	ENST00000369002.4	-	15	1642	c.1463C>G	c.(1462-1464)tCc>tGc	p.S488C		NM_007214.4	NP_009145.1	Q9UGP8	SEC63_HUMAN	SEC63 homolog (S. cerevisiae)	488	SEC63 1.				protein folding|protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|receptor activity|unfolded protein binding			endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		all_cancers(87;5.35e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00225)|Colorectal(196;0.0294)		BRCA - Breast invasive adenocarcinoma(108;0.0079)|Epithelial(106;0.0356)|all cancers(137;0.0525)|OV - Ovarian serous cystadenocarcinoma(136;0.054)		AGCACAGATGGACTGCTCCTT	0.383000													38	36					0	0	0.104719	0	0
ARHGAP31	57514	broad.mit.edu	37	3	119102036	119102036	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr3:119102036C>G	ENST00000264245.4	+	6	1177	c.645C>G	c.(643-645)atC>atG	p.I215M		NM_020754.2	NP_065805.2	Q2M1Z3	RHG31_HUMAN	Rho GTPase activating protein 31	215	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity	p.I215I(1)		breast(5)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(3)|large_intestine(11)|lung(29)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	67						TAGATCAAATCTTTAACAACG	0.473000													34	41					0	0	0.045705	0	0
HMHA1	23526	broad.mit.edu	37	19	1082962	1082962	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr19:1082962G>A	ENST00000313093.2	+	20	2872	c.2641G>A	c.(2641-2643)Gag>Aag	p.E881K	HMHA1_ENST00000539243.2_Missense_Mutation_p.E897K|HMHA1_ENST00000591169.1_3'UTR|HMHA1_ENST00000543365.1_Missense_Mutation_p.E764K|HMHA1_ENST00000536472.1_Missense_Mutation_p.E749K|HMHA1_ENST00000586866.1_Missense_Mutation_p.E885K|HMHA1_ENST00000590577.1_Missense_Mutation_p.E516K|HMHA1_ENST00000590214.1_Missense_Mutation_p.E908K	NM_012292.3	NP_036424.2	Q92619	HMHA1_HUMAN	histocompatibility (minor) HA-1	881	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|lung(7)|ovary(1)|prostate(2)	16		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCGGAGAGCGAGGCAGTGGC	0.726000													9	3					0	0	0.069234	0	0
POLQ	10721	broad.mit.edu	37	3	121200455	121200455	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr3:121200455G>C	ENST00000264233.5	-	19	6303	c.6175C>G	c.(6175-6177)Cag>Gag	p.Q2059E		NM_199420.3	NP_955452.3	O75417	DPOLQ_HUMAN	polymerase (DNA directed), theta	2059					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(55)|ovary(5)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	120				GBM - Glioblastoma multiforme(114;0.0915)		GAGTTGAGCTGATTCATAGAG	0.418000								DNA polymerases (catalytic subunits)					34	30					0	0	0.050027	0	0
TNN	63923	broad.mit.edu	37	1	175067659	175067659	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:175067659G>T	ENST00000239462.4	+	9	2160	c.2047G>T	c.(2047-2049)Gag>Tag	p.E683*		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	683	Fibronectin type-III 5.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		ACCGGGTATGGAGTACATGGT	0.612000													34	42					4.3181e-19	4.57529e-19	0.054565	1	0
TTC39A	22996	broad.mit.edu	37	1	51768066	51768066	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:51768066G>C	ENST00000262676.5	-	11	1110	c.950C>G	c.(949-951)gCa>gGa	p.A317G	TTC39A_ENST00000447632.2_Missense_Mutation_p.A321G|TTC39A_ENST00000371747.3_Missense_Mutation_p.A320G|TTC39A_ENST00000262675.7_Missense_Mutation_p.A258G|TTC39A_ENST00000371750.5_Missense_Mutation_p.A286G|TTC39A_ENST00000413473.2_Missense_Mutation_p.A289G|TTC39A_ENST00000451380.1_Missense_Mutation_p.A285G			Q5SRH9	TT39A_HUMAN	tetratricopeptide repeat domain 39A	321							binding	p.0?(2)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(2)|prostate(2)|skin(3)|urinary_tract(1)	17						AATCCTCCCTGCAAAGAACAG	0.597000													7	15					0	0	0.029380	0	0
KANK4	163782	broad.mit.edu	37	1	62703978	62703978	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:62703978C>T	ENST00000371153.4	-	10	3337	c.2959G>A	c.(2959-2961)Gcg>Acg	p.A987T	KANK4_ENST00000371150.1_Missense_Mutation_p.A343T|KANK4_ENST00000317477.4_Missense_Mutation_p.A125T|KANK4_ENST00000354381.3_Missense_Mutation_p.A359T	NM_181712.4	NP_859063.3	Q5T7N3	KANK4_HUMAN	KN motif and ankyrin repeat domains 4	987			A -> V (in dbSNP:rs34591898).							NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(49)|ovary(3)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	81						CCCTGCTCCGCGTGGGCTCTC	0.577000													29	34					0	0	0.116897	0	0
CDC42BPA	8476	broad.mit.edu	37	1	227203874	227203874	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:227203874C>A	ENST00000366769.3	-	33	5950	c.4659G>T	c.(4657-4659)atG>atT	p.M1553I	CDC42BPA_ENST00000366766.2_Missense_Mutation_p.M1588I|CDC42BPA_ENST00000366765.3_Missense_Mutation_p.M1566I|CDC42BPA_ENST00000366767.3_Missense_Mutation_p.M1472I|CDC42BPA_ENST00000366764.2_Missense_Mutation_p.M1525I|CDC42BPA_ENST00000334218.5_Missense_Mutation_p.M1553I|CDC42BPA_ENST00000535525.1_Missense_Mutation_p.M1533I	NM_003607.3	NP_003598.2	Q5VT25	MRCKA_HUMAN	CDC42 binding protein kinase alpha (DMPK-like)	1566					actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(12)|lung(32)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|urinary_tract(2)	77		all_cancers(173;0.156)|Prostate(94;0.0792)				ATTTATTTCTCATTTCTGGAT	0.338000													35	42					3.03874e-20	3.24004e-20	0.059317	1	0
GPR124	25960	broad.mit.edu	37	8	37693267	37693267	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr8:37693267C>T	ENST00000412232.2	+	13	2042	c.2029C>T	c.(2029-2031)Ccc>Tcc	p.P677S	GPR124_ENST00000315215.7_Intron	NM_032777.9	NP_116166.9	Q96PE1	GP124_HUMAN	G protein-coupled receptor 124	677					central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(16)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	37			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			CGTGGCCACCCCCGTCATCTT	0.652000													18	45					0	0	0.038395	0	0
DGKK	139189	broad.mit.edu	37	X	50111901	50111901	+	RNA	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chrX:50111901G>C	ENST00000376025.2	-	0	3912							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					TTTTTTAGTAGAATTCTCAAT	0.398000													12	1					0	0	0.105934	0	0
INTS5	80789	broad.mit.edu	37	11	62415620	62415620	+	Silent	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr11:62415620G>A	ENST00000330574.2	-	2	1984	c.1932C>T	c.(1930-1932)ctC>ctT	p.L644L		NM_030628.1	NP_085131.1	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	644					snRNA processing	integral to membrane|integrator complex	protein binding			breast(1)|endometrium(4)|large_intestine(6)|lung(20)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	36						CCAGTCCCAGGAGCTGGGAGG	0.602000													28	27					0	0	0.125774	0	0
GEMIN2	8487	broad.mit.edu	37	14	39583588	39583588	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr14:39583588C>T	ENST00000308317.6	+	1	162	c.79C>T	c.(79-81)Cgg>Tgg	p.R27W	GEMIN2_ENST00000250379.8_Missense_Mutation_p.R27W|GEMIN2_ENST00000396249.2_Missense_Mutation_p.R27W	NM_003616.2	NP_003607.1	O14893	GEMI2_HUMAN	gem (nuclear organelle) associated protein 2	27					ncRNA metabolic process|spliceosomal snRNP assembly|spliceosome assembly	Cajal body|cytosol|spliceosomal complex	protein binding										GTTGATGCCTCGGCTATTGCC	0.602000													26	18					0	0	0.099896	0	0
EIF4G1	1981	broad.mit.edu	37	3	184037480	184037480	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr3:184037480G>A	ENST00000342981.4	+	6	842	c.428G>A	c.(427-429)gGc>gAc	p.G143D	EIF4G1_ENST00000350481.5_5'UTR|EIF4G1_ENST00000427845.1_Missense_Mutation_p.G56D|EIF4G1_ENST00000414031.1_Missense_Mutation_p.G103D|EIF4G1_ENST00000424196.1_Missense_Mutation_p.G150D|EIF2B5_ENST00000444495.1_Intron|EIF4G1_ENST00000392537.2_Missense_Mutation_p.G56D|EIF4G1_ENST00000319274.6_Missense_Mutation_p.G143D|EIF4G1_ENST00000382330.3_Missense_Mutation_p.G150D|EIF4G1_ENST00000346169.2_Missense_Mutation_p.G143D|EIF4G1_ENST00000411531.1_Missense_Mutation_p.G103D|EIF4G1_ENST00000352767.3_Missense_Mutation_p.G150D	NM_182917.4	NP_886553	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4 gamma, 1	143					insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(5)|large_intestine(14)|lung(41)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	75	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CCCCAAGCTGGCGCCTACTAT	0.607000													7	9					0	0	0.029380	0	0
USP15	9958	broad.mit.edu	37	12	62777719	62777719	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr12:62777719G>C	ENST00000280377.5	+	10	1246	c.1188G>C	c.(1186-1188)ttG>ttC	p.L396F	USP15_ENST00000393654.3_Missense_Mutation_p.L371F|USP15_ENST00000353364.3_Missense_Mutation_p.L367F	NM_001252078.1	NP_001239007.1	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	396					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(15)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	37			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		ATGAGGATTTGAATAGAATTA	0.353000													24	37					0	0	0.069288	0	0
VPS33A	65082	broad.mit.edu	37	12	122748132	122748132	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr12:122748132C>T	ENST00000267199.4	-	3	395	c.283G>A	c.(283-285)Gaa>Aaa	p.E95K	VPS33A_ENST00000542310.1_5'UTR|RP11-512M8.5_ENST00000535844.1_Missense_Mutation_p.E95K|VPS33A_ENST00000451053.2_Missense_Mutation_p.E95K	NM_022916.4	NP_075067.2	Q96AX1	VP33A_HUMAN	vacuolar protein sorting 33 homolog A (S. cerevisiae)	95					lysosome localization|melanosome localization|platelet formation|protein transport|regulation of developmental pigmentation|vesicle docking involved in exocytosis	early endosome|late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(13)|ovary(1)|skin(2)	28	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000336)|Epithelial(86;0.000606)|BRCA - Breast invasive adenocarcinoma(302;0.23)		AGCACGTTTTCAGCGATTATA	0.383000													28	25					0	0	0.108266	0	0
CCDC88C	440193	broad.mit.edu	37	14	91779817	91779817	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr14:91779817C>G	ENST00000389857.6	-	15	2429	c.2343G>C	c.(2341-2343)aaG>aaC	p.K781N		NM_001080414.3	NP_001073883.2	Q9P219	DAPLE_HUMAN	coiled-coil domain containing 88C	781					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(6)|pancreas(1)|urinary_tract(1)	24		all_cancers(154;0.0468)				AGGTCTGCGTCTTGTGGCTGC	0.672000													24	17					0	0	0.099896	0	0
KCNK1	3775	broad.mit.edu	37	1	233750167	233750167	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:233750167G>A	ENST00000366621.3	+	1	418	c.250G>A	c.(250-252)Gag>Aag	p.E84K		NM_002245.3	NP_002236.1	O00180	KCNK1_HUMAN	potassium channel, subfamily K, member 1	84						voltage-gated potassium channel complex	inward rectifier potassium channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)	11		all_cancers(173;0.00217)|all_epithelial(177;0.121)|Prostate(94;0.122)|Acute lymphoblastic leukemia(190;0.175)			Ibutilide(DB00308)|Quinidine(DB00908)	CCGGGTGCTGGAGGCCAGCAA	0.652000													9	17					0	0	0.047766	0	0
CCRL2	9034	broad.mit.edu	37	3	46450001	46450001	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr3:46450001G>C	ENST00000399036.3	+	2	783	c.431G>C	c.(430-432)aGg>aCg	p.R144T	CCRL2_ENST00000400882.2_Missense_Mutation_p.R144T|CCRL2_ENST00000357392.4_Missense_Mutation_p.R156T|CCRL2_ENST00000400880.3_Missense_Mutation_p.R144T	NM_003965.4	NP_003956.2	O00421	CCRL2_HUMAN	chemokine (C-C motif) receptor-like 2						chemotaxis|inflammatory response	integral to plasma membrane	CCR chemokine receptor binding|chemokine receptor activity			lung(3)|ovary(1)|urinary_tract(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.00112)|KIRC - Kidney renal clear cell carcinoma(197;0.017)|Kidney(197;0.02)		GCCAGGAGGAGGGTGCCCTGT	0.478000													44	3					0	0	0.111260	0	0
GABRA1	2554	broad.mit.edu	37	5	161322862	161322862	+	Silent	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr5:161322862G>C	ENST00000428797.2	+	10	1402	c.1047G>C	c.(1045-1047)gtG>gtC	p.V349V	GABRA1_ENST00000023897.6_Silent_p.V349V|GABRA1_ENST00000420560.1_Silent_p.V349V|GABRA1_ENST00000437025.2_Silent_p.V349V|GABRA1_ENST00000393943.4_Silent_p.V349V|GABRA1_ENST00000444819.1_Silent_p.V349V	NM_001127643.1	NP_001121115.1	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 1	349					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|endometrium(2)|kidney(3)|large_intestine(4)|liver(1)|lung(22)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(1)	42	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	GCAAAAGTGTGGTTCCAGAAA	0.388000													32	26					0	0	0.050027	0	0
EP300	2033	broad.mit.edu	37	22	41566488	41566488	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr22:41566488G>C	ENST00000263253.7	+	27	5584	c.4365G>C	c.(4363-4365)caG>caC	p.Q1455H	RP1-85F18.6_ENST00000415054.1_RNA	NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	1455					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						CTCCTGACCAGAAGATACCCA	0.443000			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				39	48					0	0	0.080422	0	0
RAB3A	5864	broad.mit.edu	37	19	18311166	18311166	+	Silent	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr19:18311166G>A	ENST00000222256.4	-	3	496	c.318C>T	c.(316-318)aaC>aaT	p.N106N	RAB3A_ENST00000464076.3_Silent_p.N11N	NM_002866.4	NP_002857.1	P20336	RAB3A_HUMAN	RAB3A, member RAS oncogene family	106					glutamate secretion|protein transport|small GTPase mediated signal transduction	clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|plasma membrane|synaptic vesicle	GTP binding|GTPase activity			NS(1)|kidney(1)|large_intestine(2)|lung(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	8						AGGATTCCTCGTTGGTGATGT	0.502000													55	56					0	0	0.139131	0	0
LOX	4015	broad.mit.edu	37	5	121405766	121405766	+	Nonsense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr5:121405766G>C	ENST00000231004.4	-	6	1528	c.1229C>G	c.(1228-1230)tCa>tGa	p.S410*	LOX_ENST00000513319.1_5'UTR|SRFBP1_ENST00000504881.1_Intron	NM_001178102.1|NM_002317.5	NP_001171573.1|NP_002308.2	P28300	LYOX_HUMAN	lysyl oxidase	410	Lysyl-oxidase like.				protein modification process	extracellular space	copper ion binding|protein-lysine 6-oxidase activity			endometrium(1)|lung(6)|prostate(1)	8		all_cancers(142;0.0124)|Prostate(80;0.0322)|Ovarian(225;0.0814)|Breast(839;0.143)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;2.14e-11)|OV - Ovarian serous cystadenocarcinoma(64;7.87e-10)|all cancers(49;2.49e-09)|COAD - Colon adenocarcinoma(49;0.02)		TGTGCAGCCTGAGGCATACGC	0.408000													47	67					0	0	0.124865	0	0
HTRA4	203100	broad.mit.edu	37	8	38831911	38831911	+	Silent	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr8:38831911C>G	ENST00000302495.4	+	1	229	c.129C>G	c.(127-129)gtC>gtG	p.V43V		NM_153692.3	NP_710159.1	P83105	HTRA4_HUMAN	HtrA serine peptidase 4	43	IGFBP N-terminal.				proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(7)|upper_aerodigestive_tract(1)	11		all_lung(54;0.0344)|Hepatocellular(245;0.0512)|Lung NSC(58;0.0955)	LUSC - Lung squamous cell carcinoma(45;1.5e-07)			GCCCCGCGGTCTGCCAGCCCA	0.746000													4	6					0	0	0.021553	0	0
OR51I2	390064	broad.mit.edu	37	11	5475265	5475265	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr11:5475265G>C	ENST00000341449.2	+	1	628	c.547G>C	c.(547-549)Gac>Cac	p.D183H	HBG2_ENST00000380252.1_Intron|AC104389.28_ENST00000415970.1_RNA|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380259.2_Intron	NM_001004754.2	NP_001004754.1	Q9H344	O51I2_HUMAN	olfactory receptor, family 51, subfamily I, member 2	183					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.09e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCTGCACCCAGACATGATGAG	0.453000													52	62					0	0	0.139131	0	0
NACA	4666	broad.mit.edu	37	12	57110190	57110190	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr12:57110190C>G	ENST00000454682.1	-	3	5405	c.5124G>C	c.(5122-5124)aaG>aaC	p.K1708N	NACA_ENST00000550952.1_Intron|NACA_ENST00000551793.1_Intron|NACA_ENST00000356769.3_Intron|NACA_ENST00000552540.1_Intron|NACA_ENST00000548563.1_Intron|NACA_ENST00000546392.1_Intron|NACA_ENST00000393891.4_Intron	NM_001113203.2	NP_001106674.2	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha subunit	0					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	10						TAGCAGAACTCTTTTTGGTCT	0.522000			T	BCL6	NHL								143	160					0	0	0.139131	0	0
PDPN	10630	broad.mit.edu	37	1	13910364	13910364	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:13910364G>A	ENST00000294489.6	+	1	405	c.64G>A	c.(64-66)Gaa>Aaa	p.E22K	PDPN_ENST00000376057.4_Missense_Mutation_p.E22K			Q86YL7	PDPN_HUMAN	podoplanin	0					cell morphogenesis|lymphangiogenesis|regulation of cell shape	filopodium membrane|integral to plasma membrane|lamellipodium membrane|microvillus membrane|ruffle membrane				endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	16	Ovarian(185;0.249)	all_lung(284;2.29e-05)|Lung NSC(185;4.37e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00969)|Colorectal(212;4.48e-06)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000347)|Kidney(185;0.00087)|KIRC - Kidney renal clear cell carcinoma(229;0.0027)|STAD - Stomach adenocarcinoma(313;0.00802)|READ - Rectum adenocarcinoma(331;0.0678)		TAGGGTCTGGGAAGCTCGGGC	0.682000													47	47					0	0	0.124865	0	0
NHLRC2	374354	broad.mit.edu	37	10	115664742	115664742	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr10:115664742C>A	ENST00000369301.3	+	10	2083	c.1871C>A	c.(1870-1872)tCa>tAa	p.S624*		NM_198514.3	NP_940916.2	Q8NBF2	NHLC2_HUMAN	NHL repeat containing 2	624					cell redox homeostasis					breast(1)|endometrium(2)|kidney(4)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	15				Epithelial(162;0.017)|all cancers(201;0.0187)		GACCTCCCATCAGGATCAAAG	0.428000													35	43					6.2361e-21	6.67026e-21	0.098360	1	0
RPSAP58	388524	broad.mit.edu	37	19	24010594	24010594	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr19:24010594G>C	ENST00000496398.1	+	4	1054	c.631G>C	c.(631-633)Gaa>Caa	p.E211Q	RP11-255H23.4_ENST00000599944.1_lincRNA|RPSAP58_ENST00000354585.4_Missense_Mutation_p.E211Q|RP11-255H23.2_ENST00000471224.1_RNA																endometrium(1)|kidney(5)|lung(2)|prostate(1)|urinary_tract(1)	10						TGAAGAGATTGAAAAAGAAGA	0.532000													12	12					0	0	0.146539	0	0
PPAN	56342	broad.mit.edu	37	19	10224985	10224985	+	Silent	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr19:10224985G>A	ENST00000556468.1	+	13	1983	c.1956G>A	c.(1954-1956)gtG>gtA	p.V652V	PPAN-P2RY11_ENST00000428358.1_3'UTR|PPAN-P2RY11_ENST00000393796.4_Silent_p.V652V|P2RY11_ENST00000321826.4_Silent_p.V232V					peter pan homolog (Drosophila)											endometrium(3)|liver(2)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	15			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			GGCGGGCCGTGCTACGCAGCC	0.692000													41	49					0	0	0.086207	0	0
USP35	57558	broad.mit.edu	37	11	77921319	77921319	+	Silent	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr11:77921319C>T	ENST00000529308.1	+	10	2679	c.2418C>T	c.(2416-2418)ctC>ctT	p.L806L	USP35_ENST00000526425.1_Silent_p.L537L|USP35_ENST00000530267.1_Silent_p.L374L|USP35_ENST00000530535.1_3'UTR|USP35_ENST00000441408.2_Silent_p.L392L	NM_020798.2	NP_065849.1	Q9P2H5	UBP35_HUMAN	ubiquitin specific peptidase 35	806					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			endometrium(6)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(3)|urinary_tract(1)	23	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.04e-25)			ACCTCATCCTCACACTGCTGC	0.627000													50	64					0	0	0.139131	0	0
PLCL2	23228	broad.mit.edu	37	3	17051901	17051901	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr3:17051901A>G	ENST00000418129.2	+	2	1150	c.685A>G	c.(685-687)Aaa>Gaa	p.K229E	PLCL2_ENST00000460467.1_Intron|PLCL2_ENST00000432376.1_Missense_Mutation_p.K229E|PLCL2_ENST00000396755.2_Missense_Mutation_p.K229E	NM_001144382.1	NP_001137854.1	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2	355	PH.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	43						TTCAAGCAATAAAGAATTCCT	0.353000													22	19					0	0	0.055883	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54903724	54903724	+	Silent	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr12:54903724C>T	ENST00000293373.6	+	7	769	c.690C>T	c.(688-690)ctC>ctT	p.L230L	NCKAP1L_ENST00000552211.1_3'UTR|NCKAP1L_ENST00000545638.2_Silent_p.L180L	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	230					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						TTCTAAGCCTCATCAGCAACC	0.522000													80	83					0	0	0.139131	0	0
NUTM2D	728130	broad.mit.edu	37	10	89127109	89127109	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr10:89127109C>G	ENST00000412718.1	+	7	2200	c.1654C>G	c.(1654-1656)Cca>Gca	p.P552A						NUT family member 2D																		TTCAGATGCTCCAGGGACTGA	0.622000													12	22					0	0	0.146539	0	0
COL5A3	50509	broad.mit.edu	37	19	10104307	10104307	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr19:10104307C>G	ENST00000264828.3	-	18	1768	c.1683G>C	c.(1681-1683)gaG>gaC	p.E561D		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	561	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			TTTGGCCCTTCTCACCAGGCA	0.577000													31	36					0	0	0.054565	0	0
IL1RAPL1	11141	broad.mit.edu	37	X	29973573	29973573	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chrX:29973573G>C	ENST00000378993.1	+	11	2400	c.1727G>C	c.(1726-1728)aGt>aCt	p.S576T	IL1RAPL1_ENST00000302196.4_Missense_Mutation_p.S576T	NM_014271.3	NP_055086.1	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	576	Interaction with NCS1.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			biliary_tract(1)|breast(1)|endometrium(5)|large_intestine(9)|lung(38)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62						TTAGATGTCAGTGAGCAAGGG	0.498000													26	0					0	0	0.125774	0	0
HSPG2	3339	broad.mit.edu	37	1	22181905	22181905	+	Silent	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:22181905C>T	ENST00000374695.3	-	47	5968	c.5889G>A	c.(5887-5889)gaG>gaA	p.E1963E		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	1963	Ig-like C2-type 5.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CCTGGGTCCTCTCTGGGCTCA	0.692000													16	30					0	0	0.033300	0	0
NFATC3	4775	broad.mit.edu	37	16	68156357	68156357	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr16:68156357G>A	ENST00000349223.5	+	2	795	c.571G>A	c.(571-573)Gat>Aat	p.D191N	NFATC3_ENST00000346183.3_Missense_Mutation_p.D191N|NFATC3_ENST00000329524.4_Missense_Mutation_p.D191N|NFATC3_ENST00000575270.1_Missense_Mutation_p.D191N|NFATC3_ENST00000535127.2_3'UTR	NM_173163.2	NP_775186.1	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	191					inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	44		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		TATTTATGATGATGTGGACTC	0.507000													39	41					0	0	0.080422	0	0
BSN	8927	broad.mit.edu	37	3	49695503	49695503	+	Silent	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr3:49695503G>A	ENST00000296452.4	+	5	8628	c.8514G>A	c.(8512-8514)acG>acA	p.T2838T		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	2838					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GCCAGCAGACGCTGCCTCGCC	0.617000													57	5					0	0	0.139131	0	0
CD28	940	broad.mit.edu	37	2	204594410	204594410	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr2:204594410C>T	ENST00000324106.8	+	3	598	c.449C>T	c.(448-450)tCt>tTt	p.S150F	CD28_ENST00000374478.4_Missense_Mutation_p.S31F|CD28_ENST00000458610.2_Missense_Mutation_p.S164F|CD28_ENST00000374481.3_Missense_Mutation_p.S66F	NM_001243077.1|NM_006139.3	NP_001230006.1|NP_006130.1	P10747	CD28_HUMAN	CD28 molecule						cell surface receptor linked signaling pathway|cytokine biosynthetic process|humoral immune response|positive regulation of anti-apoptosis|positive regulation of interleukin-2 biosynthetic process|positive regulation of mitosis|positive regulation of translation|positive regulation of viral genome replication|regulation of defense response to virus by virus|regulatory T cell differentiation|T cell costimulation|viral reproduction	cytosol|external side of plasma membrane|integral to plasma membrane	coreceptor activity|protease binding|SH3/SH2 adaptor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	13						CCCGGACCTTCTAAGCCCTTT	0.443000													68	3					0	0	0.139131	0	0
MYO16	23026	broad.mit.edu	37	13	109707814	109707814	+	Nonsense_Mutation	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr13:109707814C>G	ENST00000356711.2	+	27	3266	c.3140C>G	c.(3139-3141)tCa>tGa	p.S1047*	MYO16_ENST00000357550.2_Nonsense_Mutation_p.S1047*|MYO16_ENST00000457511.2_Nonsense_Mutation_p.S559*	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	1047	Myosin head-like 2.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CCCAATAACTCAAAGCTGCCA	0.403000													26	71					0	0	0.083992	0	0
EXOSC4	54512	broad.mit.edu	37	8	145135366	145135366	+	Silent	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr8:145135366G>A	ENST00000316052.5	+	3	703	c.600G>A	c.(598-600)gaG>gaA	p.E200E	EXOSC4_ENST00000525936.1_3'UTR	NM_019037.2	NP_061910.1	Q9NPD3	EXOS4_HUMAN	exosome component 4	200					DNA deamination|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|maturation of 5.8S rRNA|nuclear mRNA surveillance|positive regulation of cell growth	cytosol|exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5'-exoribonuclease activity|AU-rich element binding|protein binding			lung(4)|prostate(1)|upper_aerodigestive_tract(2)	7	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;3.48e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CGCTGCTTGAGATGGATGCCC	0.672000													47	51					0	0	0.139131	0	0
CNST	163882	broad.mit.edu	37	1	246810871	246810871	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:246810871G>C	ENST00000366513.4	+	9	1637	c.1368G>C	c.(1366-1368)caG>caC	p.Q456H	CNST_ENST00000483271.1_3'UTR|CNST_ENST00000366512.3_Missense_Mutation_p.Q456H	NM_152609.2	NP_689822.2	Q6PJW8	CNST_HUMAN	consortin, connexin sorting protein	456					positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|urinary_tract(2)	28						CACAGGCTCAGAGGAAAGAAC	0.468000											OREG0014367	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	88	113					0	0	0.139131	0	0
DNMT3A	1788	broad.mit.edu	37	2	25472585	25472585	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr2:25472585C>G	ENST00000380746.4	-	2	126	c.13G>C	c.(13-15)Gag>Cag	p.E5Q	DNMT3A_ENST00000264709.3_Intron|DNMT3A_ENST00000402667.1_Intron|DNMT3A_ENST00000321117.5_Intron	NM_153759.3	NP_715640.2	Q9Y6K1	DNM3A_HUMAN	DNA (cytosine-5-)-methyltransferase 3 alpha	0					regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(964)|kidney(3)|large_intestine(10)|lung(29)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	1021	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACAACCCGCTCCAGGATCCCT	0.493000			"""Mis, F, N, S"""		AML								46	2					0	0	0.139131	0	0
NSD1	64324	broad.mit.edu	37	5	176638788	176638788	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr5:176638788G>C	ENST00000439151.2	+	5	3433	c.3388G>C	c.(3388-3390)Gaa>Caa	p.E1130Q	NSD1_ENST00000361032.4_Missense_Mutation_p.E1027Q|NSD1_ENST00000347982.4_Missense_Mutation_p.E861Q|NSD1_ENST00000354179.4_Missense_Mutation_p.E861Q	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1130					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		ACTCTCTTTTGAAAACGGAAA	0.408000			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			15	0					0	0	0.132662	0	0
FANCM	57697	broad.mit.edu	37	14	45645029	45645029	+	Silent	SNP	C	C	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr14:45645029C>A	ENST00000267430.5	+	14	3157	c.3072C>A	c.(3070-3072)ccC>ccA	p.P1024P	FANCM_ENST00000542564.2_Silent_p.P998P	NM_020937.2	NP_065988.1	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	1024					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(31)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	85						TTTTCTTACCCTGTGCAGAGC	0.373000								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				28	27					2.48779e-11	2.55585e-11	0.108266	1	0
PMFBP1	83449	broad.mit.edu	37	16	72159997	72159997	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr16:72159997T>C	ENST00000537465.1	-	15	2296	c.2138A>G	c.(2137-2139)cAg>cGg	p.Q713R	PMFBP1_ENST00000237353.10_Missense_Mutation_p.Q708R|PMFBP1_ENST00000355636.6_Missense_Mutation_p.Q563R			Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	713										NS(1)|breast(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	45		Ovarian(137;0.179)				CAGCTGGGCCTGCAGGCTCAT	0.532000													4	261					0	0	0.014758	0	0
TAS1R3	83756	broad.mit.edu	37	1	1269301	1269301	+	Silent	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:1269301G>A	ENST00000339381.5	+	6	2048	c.2016G>A	c.(2014-2016)ctG>ctA	p.L672L		NM_152228.1	NP_689414	Q7RTX0	TS1R3_HUMAN	taste receptor, type 1, member 3	672					detection of chemical stimulus involved in sensory perception of sweet taste|sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			kidney(2)|lung(8)|upper_aerodigestive_tract(1)|urinary_tract(1)	12	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.88e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.146)	Aspartame(DB00168)	CAGACCGGCTGAGTGGCTGCC	0.687000													33	48					0	0	0.050027	0	0
FILIP1L	11259	broad.mit.edu	37	3	99649630	99649630	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr3:99649630G>C	ENST00000331335.5	-	2	705	c.235C>G	c.(235-237)Ctg>Gtg	p.L79V	FILIP1L_ENST00000354552.3_Missense_Mutation_p.L79V|FILIP1L_ENST00000398326.2_Missense_Mutation_p.L79V|CMSS1_ENST00000421999.2_Intron|CMSS1_ENST00000496116.1_Intron	NM_001042459.1	NP_001035924.1	Q4L180	FIL1L_HUMAN	filamin A interacting protein 1-like	79						cytoplasm|membrane|myosin complex|nucleus				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	35						TCTCCCTCCAGAATGCTGAGG	0.493000													19	16					0	0	0.049695	0	0
ANKRD12	23253	broad.mit.edu	37	18	9258475	9258475	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr18:9258475G>C	ENST00000262126.4	+	9	5450	c.5210G>C	c.(5209-5211)aGa>aCa	p.R1737T	ANKRD12_ENST00000400020.3_Missense_Mutation_p.R1714T|ANKRD12_ENST00000383440.2_Missense_Mutation_p.R1714T	NM_015208.4	NP_056023.3	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12							nucleus				NS(1)|breast(3)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(20)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(2)	65						AGAATGACTAGAAACAAAGCA	0.343000													20	9					0	0	0.049695	0	0
RNF214	257160	broad.mit.edu	37	11	117105073	117105073	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr11:117105073G>A	ENST00000530849.1	+	1	95	c.85G>A	c.(85-87)Gaa>Aaa	p.E29K	RNF214_ENST00000531287.1_Missense_Mutation_p.E29K|RNF214_ENST00000531452.1_Missense_Mutation_p.E29K|RNF214_ENST00000300650.4_Missense_Mutation_p.E29K			Q8ND24	RN214_HUMAN	ring finger protein 214	29							zinc ion binding			cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	23	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.88e-05)|Epithelial(105;0.000397)|all cancers(92;0.00258)		CAAATCAGACGAAGGTCTCCC	0.478000													50	50					0	0	0.139131	0	0
HMBOX1	79618	broad.mit.edu	37	8	28902932	28902932	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr8:28902932C>G	ENST00000397358.3	+	8	1610	c.906C>G	c.(904-906)aaC>aaG	p.N302K	HMBOX1_ENST00000519047.1_Missense_Mutation_p.N302K|HMBOX1_ENST00000524238.1_Missense_Mutation_p.N302K|HMBOX1_ENST00000523613.1_Missense_Mutation_p.N302K|HMBOX1_ENST00000444075.1_Missense_Mutation_p.N302K|HMBOX1_ENST00000558662.1_Missense_Mutation_p.N302K|HMBOX1_ENST00000287701.10_Missense_Mutation_p.N302K|HMBOX1_ENST00000355231.5_Missense_Mutation_p.N302K	NM_024567.3	NP_078843.2	Q6NT76	HMBX1_HUMAN	homeobox containing 1	302					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)	11		Ovarian(32;0.0192)		KIRC - Kidney renal clear cell carcinoma(542;0.135)|Kidney(114;0.161)		AAATTGCAAACGCTTGCAATG	0.458000													59	57					0	0	0.139131	0	0
SUPT16H	11198	broad.mit.edu	37	14	21831283	21831283	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr14:21831283C>T	ENST00000216297.2	-	13	1759	c.1421G>A	c.(1420-1422)cGa>cAa	p.R474Q		NM_007192.3	NP_009123.1	Q9Y5B9	SP16H_HUMAN	suppressor of Ty 16 homolog (S. cerevisiae)	474					DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		ATGTGCTCTTCGCTTCTCTTC	0.398000													50	62					0	0	0.139131	0	0
ALDH16A1	126133	broad.mit.edu	37	19	49965915	49965915	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr19:49965915G>A	ENST00000293350.4	+	8	1164	c.1001G>A	c.(1000-1002)cGa>cAa	p.R334Q	ALDH16A1_ENST00000540132.1_Missense_Mutation_p.R171Q|ALDH16A1_ENST00000433981.2_Missense_Mutation_p.R169Q|ALDH16A1_ENST00000455361.2_Missense_Mutation_p.R283Q	NM_153329.3	NP_699160.2	Q8IZ83	A16A1_HUMAN	aldehyde dehydrogenase 16 family, member A1	334							oxidoreductase activity|protein binding			cervix(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|skin(2)|urinary_tract(3)	20		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0251)		CGGAGTGGCCGAGGGCTGGAT	0.672000													42	36					0	0	0.098360	0	0
CTAGE5	4253	broad.mit.edu	37	14	39777766	39777766	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr14:39777766C>G	ENST00000553728.1	+	17	2986	c.2773C>G	c.(2773-2775)Caa>Gaa	p.Q925E	CTAGE5_ENST00000396158.2_Missense_Mutation_p.Q395E|RP11-407N17.3_ENST00000603904.1_Missense_Mutation_p.Q361E|CTAGE5_ENST00000341502.5_Missense_Mutation_p.Q390E|CTAGE5_ENST00000341749.3_Missense_Mutation_p.Q378E|CTAGE5_ENST00000348007.3_Missense_Mutation_p.Q390E|CTAGE5_ENST00000553352.1_Missense_Mutation_p.Q361E|CTAGE5_ENST00000396165.4_Missense_Mutation_p.Q361E|CTAGE5_ENST00000556148.1_Missense_Mutation_p.Q315E|CTAGE5_ENST00000280083.3_Missense_Mutation_p.Q390E|CTAGE5_ENST00000557038.1_Missense_Mutation_p.Q310E																							TGAATTATATCAAGAAAATGA	0.299000													39	65					0	0	0.092188	0	0
AATK	9625	broad.mit.edu	37	17	79095226	79095226	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr17:79095226G>A	ENST00000326724.4	-	11	2534	c.2510C>T	c.(2509-2511)gCc>gTc	p.A837V	AATK_ENST00000417379.1_Missense_Mutation_p.A734V	NM_001080395.2	NP_001073864.2	Q6ZMQ8	LMTK1_HUMAN	apoptosis-associated tyrosine kinase	837						integral to membrane|mitochondrion|perinuclear region of cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(2)|kidney(2)|lung(8)|ovary(3)|prostate(1)|stomach(4)|upper_aerodigestive_tract(1)	21	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			CAGCTTGATGGCAGACACCTC	0.672000													10	7					0	0	0.058154	0	0
GAS2L1	10634	broad.mit.edu	37	22	29704343	29704343	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr22:29704343G>A	ENST00000471961.1	+	1	1296	c.248G>A	c.(247-249)cGa>cAa	p.R83Q	GAS2L1_ENST00000341313.6_Missense_Mutation_p.R83Q|GAS2L1_ENST00000407854.1_Missense_Mutation_p.R83Q|GAS2L1_ENST00000403764.1_Missense_Mutation_p.R83Q|GAS2L1_ENST00000360113.2_Missense_Mutation_p.R83Q|GAS2L1_ENST00000406549.3_Missense_Mutation_p.R83Q|GAS2L1_ENST00000407647.2_Missense_Mutation_p.R83Q			Q99501	GA2L1_HUMAN	growth arrest-specific 2 like 1	83	CH.				cell cycle arrest	cytoplasm|cytoskeleton				endometrium(2)|lung(2)|prostate(1)	5						CGCCCGGCCCGAGGTGTGGCC	0.692000													14	14					0	0	0.119110	0	0
TAS1R3	83756	broad.mit.edu	37	1	1267908	1267908	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:1267908G>C	ENST00000339381.5	+	3	1029	c.997G>C	c.(997-999)Gag>Cag	p.E333Q		NM_152228.1	NP_689414	Q7RTX0	TS1R3_HUMAN	taste receptor, type 1, member 3	333					detection of chemical stimulus involved in sensory perception of sweet taste|sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			kidney(2)|lung(8)|upper_aerodigestive_tract(1)|urinary_tract(1)	12	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.88e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.146)	Aspartame(DB00168)	CCAGCTGCACGAGTTCCCCCA	0.687000													16	57					0	0	0.038395	0	0
ZNF37A	7587	broad.mit.edu	37	10	38406358	38406358	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr10:38406358C>G	ENST00000361085.5	+	7	624	c.279C>G	c.(277-279)ttC>ttG	p.F93L	ZNF37A_ENST00000351773.3_Missense_Mutation_p.F93L	NM_001178101.1|NM_003421.2	NP_001171572.1|NP_003412.1	P17032	ZN37A_HUMAN	zinc finger protein 37A							nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(13)|prostate(1)	28						TAATGAAGTTCAATGAGTTTA	0.294000													47	4					0	0	0.139131	0	0
F2RL2	2151	broad.mit.edu	37	5	75914058	75914058	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr5:75914058G>T	ENST00000296641.4	-	2	677	c.474C>A	c.(472-474)aaC>aaA	p.N158K	IQGAP2_ENST00000396234.3_Intron|IQGAP2_ENST00000379730.3_Intron|IQGAP2_ENST00000502745.1_Intron|F2RL2_ENST00000504899.1_Missense_Mutation_p.N136K|IQGAP2_ENST00000274364.6_Intron	NM_004101.3	NP_004092.1	O00254	PAR3_HUMAN	coagulation factor II (thrombin) receptor-like 2	158					platelet activation	extracellular region|integral to plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|thrombin receptor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|skin(3)	32		all_lung(232;0.000462)|Lung NSC(167;0.00124)|Prostate(461;0.00955)|Ovarian(174;0.0129)		all cancers(79;4.43e-43)		CAAATACCCAGTTGTTCCCAT	0.468000													31	39					3.86903e-22	4.15153e-22	0.054565	1	0
FANCM	57697	broad.mit.edu	37	14	45645527	45645527	+	Silent	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr14:45645527C>G	ENST00000267430.5	+	14	3655	c.3570C>G	c.(3568-3570)ctC>ctG	p.L1190L	FANCM_ENST00000542564.2_Silent_p.L1164L	NM_020937.2	NP_065988.1	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	1190					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(31)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	85						ATTCTGAACTCCAAGATCAAA	0.363000								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				32	44					0	0	0.045705	0	0
KIAA0907	22889	broad.mit.edu	37	1	155891321	155891321	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:155891321G>A	ENST00000368320.3	-	10	1136	c.1111C>T	c.(1111-1113)Cag>Tag	p.Q371*	KIAA0907_ENST00000368319.3_Intron|KIAA0907_ENST00000368321.3_Nonsense_Mutation_p.Q371*|KIAA0907_ENST00000482337.1_Intron			Q7Z7F0	K0907_HUMAN	KIAA0907	371	Pro-rich.									breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|urinary_tract(1)	21	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)			ACTGGCTGCTGAGGAGGGGGA	0.517000													34	37					0	0	0.064281	0	0
TAS1R3	83756	broad.mit.edu	37	1	1267054	1267054	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:1267054G>C	ENST00000339381.5	+	2	260	c.228G>C	c.(226-228)atG>atC	p.M76I		NM_152228.1	NP_689414	Q7RTX0	TS1R3_HUMAN	taste receptor, type 1, member 3	76					detection of chemical stimulus involved in sensory perception of sweet taste|sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			kidney(2)|lung(8)|upper_aerodigestive_tract(1)|urinary_tract(1)	12	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.88e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.146)	Aspartame(DB00168)	CACTGGCCATGAAAATGGCCG	0.632000													15	52					0	0	0.119110	0	0
PRSS12	8492	broad.mit.edu	37	4	119239542	119239542	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr4:119239542G>A	ENST00000296498.3	-	5	1423	c.1141C>T	c.(1141-1143)Cct>Tct	p.P381S		NM_003619.3	NP_003610.2	P56730	NETR_HUMAN	protease, serine, 12 (neurotrypsin, motopsin)	381	SRCR 2.					membrane	scavenger receptor activity			endometrium(3)|kidney(1)|large_intestine(9)|lung(11)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	29						CCTGTTAGAGGGGTACAGGAC	0.493000													38	3					0	0	0.092188	0	0
SLC4A10	57282	broad.mit.edu	37	2	162696418	162696418	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr2:162696418G>A	ENST00000375514.5	+	5	717	c.430G>A	c.(430-432)Gag>Aag	p.E144K	SLC4A10_ENST00000493021.1_3'UTR|SLC4A10_ENST00000446997.1_Missense_Mutation_p.E133K|SLC4A10_ENST00000535165.1_Missense_Mutation_p.E133K|SLC4A10_ENST00000421911.1_Missense_Mutation_p.E133K|SLC4A10_ENST00000415876.2_Missense_Mutation_p.E133K|SLC4A10_ENST00000272716.5_Missense_Mutation_p.E133K	NM_001178016.1	NP_001171487.1	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate transporter, member 10	133					bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(35)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						TGAGGACGCTGAGTGGCGAGA	0.403000													41	9					0	0	0.111260	0	0
TPR	7175	broad.mit.edu	37	1	186344138	186344138	+	Missense_Mutation	SNP	A	A	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:186344138A>T	ENST00000367478.4	-	1	319	c.23T>A	c.(22-24)gTc>gAc	p.V8D	TPR_ENST00000474852.1_5'UTR	NM_003292.2	NP_003283.2	P12270	TPR_HUMAN	translocated promoter region, nuclear basket protein						carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			autonomic_ganglia(1)|breast(5)|central_nervous_system(4)|cervix(2)|endometrium(9)|kidney(12)|large_intestine(23)|liver(1)|lung(45)|ovary(2)|pancreas(1)|prostate(6)|skin(3)|stomach(1)|urinary_tract(8)	123		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		GCGCTCCAGGACTTGCTGCAA	0.607000			T	NTRK1	papillary thyroid								17	27					0	0	0.038395	0	0
LRRC37A4P	55073	broad.mit.edu	37	17	43587576	43587576	+	RNA	SNP	A	A	G	rs145439557	by1000genomes	TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr17:43587576A>G	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							tctgaaaagaaaagaaaaaaa	0.428000													3	50					0	0	0.115264	0	0
ZNF75D	7626	broad.mit.edu	37	X	134427717	134427717	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chrX:134427717A>G	ENST00000370766.3	-	3	3059	c.350T>C	c.(349-351)gTc>gCc	p.V117A	ZNF75D_ENST00000370764.1_Missense_Mutation_p.V117A|ZNF75D_ENST00000494295.1_Intron	NM_007131.3	NP_009062.2	P51815	ZN75D_HUMAN	zinc finger protein 75D	117	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(14)|upper_aerodigestive_tract(1)|urinary_tract(2)	31						AGCCTGTTTGACATTCTGTGG	0.468000													3	65					0	0	0.115264	0	0
PARP6	56965	broad.mit.edu	37	15	72558267	72558267	+	Silent	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr15:72558267C>T	ENST00000569795.1	-	5	834	c.147G>A	c.(145-147)gaG>gaA	p.E49E	PARP6_ENST00000287196.9_Silent_p.E49E|PARP6_ENST00000260376.7_Silent_p.E49E|PARP6_ENST00000413097.2_5'UTR			Q2NL67	PARP6_HUMAN	poly (ADP-ribose) polymerase family, member 6	49							NAD+ ADP-ribosyltransferase activity			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(8)|skin(1)|urinary_tract(1)	18						CACTGTAGATCTCCTTCACGG	0.502000													19	4					0	0	0.069288	0	0
ABCC9	10060	broad.mit.edu	37	12	22086837	22086837	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr12:22086837T>C	ENST00000261200.4	-	2	162	c.163A>G	c.(163-165)Aaa>Gaa	p.K55E	ABCC9_ENST00000345162.2_Missense_Mutation_p.K55E|ABCC9_ENST00000538350.1_Missense_Mutation_p.K55E|ABCC9_ENST00000261201.4_Missense_Mutation_p.K55E|ABCC9_ENST00000326684.4_Missense_Mutation_p.K55E	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	55					defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	ATTTGTACTTTTGAGCTTTGG	0.373000													40	48					0	0	0.124865	0	0
RB1	5925	broad.mit.edu	37	13	49050864	49050864	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr13:49050864C>T	ENST00000267163.4	+	25	2686	c.2548C>T	c.(2548-2550)Cag>Tag	p.Q850*	RB1_ENST00000484879.1_3'UTR	NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1	850	Domain C; mediates interaction with E4F1.|Interaction with LIMD1.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(11)|p.Q850*(1)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GAAAATAAATCAGATGGTATG	0.363000		6	"""D, Mis, N, F, S"""		"""retinoblastoma, sarcoma, breast, small cell lung"""	"""retinoblastoma, sarcoma, breast, small cell lung"""			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			40	0					0	0	0.086207	0	0
KCNK1	3775	broad.mit.edu	37	1	233750080	233750080	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:233750080G>A	ENST00000366621.3	+	1	331	c.163G>A	c.(163-165)Gag>Aag	p.E55K		NM_002245.3	NP_002236.1	O00180	KCNK1_HUMAN	potassium channel, subfamily K, member 1	55						voltage-gated potassium channel complex	inward rectifier potassium channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)	11		all_cancers(173;0.00217)|all_epithelial(177;0.121)|Prostate(94;0.122)|Acute lymphoblastic leukemia(190;0.175)			Ibutilide(DB00308)|Quinidine(DB00908)	GCTGCGCCAGGAGCTGCGCAA	0.632000													3	10					0	0	0.038147	0	0
RIC8A	60626	broad.mit.edu	37	11	209369	209369	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr11:209369G>A	ENST00000527696.1	+	1	301	c.77G>A	c.(76-78)aGa>aAa	p.R26K	RIC8A_ENST00000526104.1_Intron|RIC8A_ENST00000325207.5_Intron			Q9NPQ8	RIC8A_HUMAN	RIC8 guanine nucleotide exchange factor A	0						cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(3)|pancreas(1)|prostate(1)|skin(1)	13		all_cancers(49;9.23e-07)|all_epithelial(84;0.000315)|Breast(177;0.00122)|Ovarian(85;0.0202)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.45e-27)|Epithelial(43;2.94e-26)|OV - Ovarian serous cystadenocarcinoma(40;5.86e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.105)|LUSC - Lung squamous cell carcinoma(625;0.122)		GCCCCAGGAAGAAGGGCCTGG	0.647000													65	62					0	0	0.139131	0	0
MCOLN1	57192	broad.mit.edu	37	19	7591788	7591788	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr19:7591788G>C	ENST00000264079.6	+	4	672	c.547G>C	c.(547-549)Gac>Cac	p.D183H		NM_020533.2	NP_065394.1	Q9GZU1	MCLN1_HUMAN	mucolipin 1	183				ALCQRYYHRGHVDPANDTFDIDPMVVTD -> LSASGTTTE ATWTRPTTHLTLIRWWLLVN (in Ref. 3; AAG42242).	calcium ion transport|cellular iron ion homeostasis|transferrin transport	integral to plasma membrane|late endosome membrane|lysosomal membrane	cation channel activity|iron ion transmembrane transporter activity			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						CGACACATTTGACATTGATCC	0.592000													36	40					0	0	0.098360	0	0
CREB3L4	148327	broad.mit.edu	37	1	153941869	153941869	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:153941869G>A	ENST00000368607.3	+	4	747	c.481G>A	c.(481-483)Gat>Aat	p.D161N	CREB3L4_ENST00000368603.1_Missense_Mutation_p.D161N|CREB3L4_ENST00000271889.4_Missense_Mutation_p.D161N|CREB3L4_ENST00000368600.3_Missense_Mutation_p.D141N|CREB3L4_ENST00000368601.1_Missense_Mutation_p.D161N|CREB3L4_ENST00000405694.3_Missense_Mutation_p.D14N	NM_001255978.1|NM_001255980.1|NM_130898.3	NP_001242907.1|NP_001242909.1|NP_570968.1	Q8TEY5	CR3L4_HUMAN	cAMP responsive element binding protein 3-like 4	161					response to unfolded protein	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)|prostate(3)	13	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GCTGCCCTTTGATGCTCATGC	0.547000													61	42					0	0	0.139131	0	0
FUT7	2529	broad.mit.edu	37	9	139925972	139925972	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr9:139925972G>C	ENST00000314412.6	-	2	1237	c.219C>G	c.(217-219)atC>atG	p.I73M	C9orf139_ENST00000314330.2_Intron	NM_004479.3	NP_004470.1	Q11130	FUT7_HUMAN	fucosyltransferase 7 (alpha (1,3) fucosyltransferase)	73					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			NS(1)|endometrium(1)|lung(4)|ovary(1)|skin(1)	8	all_cancers(76;0.0893)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.96e-05)|Epithelial(140;0.000486)		GGCAGCGGGCGATGCCGTAGC	0.711000													4	0					0	0	0.021553	0	0
KLHL6	89857	broad.mit.edu	37	3	183209739	183209739	+	Silent	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr3:183209739G>A	ENST00000341319.3	-	7	1877	c.1842C>T	c.(1840-1842)atC>atT	p.I614I		NM_130446.2	NP_569713.2	Q8WZ60	KLHL6_HUMAN	kelch-like family member 6	614										breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(7)|kidney(1)|large_intestine(6)|liver(1)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	44	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			CTCCGGGCACGATCCTGCGGA	0.672000													45	41					0	0	0.117977	0	0
HNF4A	3172	broad.mit.edu	37	20	43052974	43052974	+	Silent	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr20:43052974C>T	ENST00000443598.2	+	8	1298	c.1209C>T	c.(1207-1209)ctC>ctT	p.L403L	HNF4A_ENST00000316099.4_Intron|HNF4A_ENST00000609795.1_Silent_p.L381L|HNF4A_ENST00000316673.4_Intron|HNF4A_ENST00000415691.2_Intron|HNF4A_ENST00000457232.1_Intron	NM_178850.2	NP_849181.1	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4, alpha	0					blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(4)|large_intestine(7)|lung(17)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(2)	34		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			gctcacccctcagctccttgg	0.592000													6	8					0	0	0.021553	0	0
ZFYVE9	9372	broad.mit.edu	37	1	52811858	52811858	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:52811858G>C	ENST00000287727.3	+	19	4415	c.4243G>C	c.(4243-4245)Gaa>Caa	p.E1415Q	ZFYVE9_ENST00000371591.1_Missense_Mutation_p.E1415Q|ZFYVE9_ENST00000357206.2_Missense_Mutation_p.E1356Q			O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9	1415					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			breast(1)|central_nervous_system(4)|endometrium(3)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	53						CGTTGTCATGGAACTCATCTT	0.478000													50	96					0	0	0.139131	0	0
SLFN12L	100506736	broad.mit.edu	37	17	33807041	33807041	+	Nonsense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr17:33807041G>C	ENST00000260908.7	-	2	305	c.188C>G	c.(187-189)tCa>tGa	p.S63*	SLFN12L_ENST00000449046.1_Nonsense_Mutation_p.S94*|SLFN12L_ENST00000361112.4_Nonsense_Mutation_p.S92*	NM_001195790.1	NP_001182719.1	Q6IEE8	SN12L_HUMAN	schlafen family member 12-like	95						integral to membrane	ATP binding			breast(1)|endometrium(4)|kidney(5)|large_intestine(2)|lung(3)|ovary(1)	16						CACAGCTCGTGAGACATTTTC	0.408000													20	26					0	0	0.055883	0	0
NCAPD3	23310	broad.mit.edu	37	11	134073692	134073692	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr11:134073692T>C	ENST00000534548.2	-	11	1389	c.1325A>G	c.(1324-1326)aAg>aGg	p.K442R		NM_015261.2	NP_056076.1	P42695	CNDD3_HUMAN	non-SMC condensin II complex, subunit D3	442					cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)		CACCAGGAACTTATGCTTTAA	0.468000													38	50					0	0	0.092188	0	0
OR10A3	26496	broad.mit.edu	37	11	7960813	7960813	+	Silent	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr11:7960813G>C	ENST00000360759.3	-	1	328	c.255C>G	c.(253-255)ctC>ctG	p.L85L		NM_001003745.1	NP_001003745.1	P58181	O10A3_HUMAN	olfactory receptor, family 10, subfamily A, member 3	85					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(5)|lung(12)|pancreas(1)|skin(2)	21				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TCTCAGTAGAGAGCACCACCA	0.473000													28	41					0	0	0.099896	0	0
BRMS1	25855	broad.mit.edu	37	11	66108729	66108729	+	Silent	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr11:66108729C>T	ENST00000359957.3	-	4	466	c.306G>A	c.(304-306)acG>acA	p.T102T	BRMS1_ENST00000425825.2_Silent_p.T102T	NM_015399.3	NP_056214.1	Q9HCU9	BRMS1_HUMAN	breast cancer metastasis suppressor 1	102					apoptosis|negative regulation of anti-apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of anoikis|positive regulation of protein deacetylation|transcription, DNA-dependent	cytoplasm|nucleus	NF-kappaB binding			large_intestine(1)|liver(1)|lung(1)|prostate(1)|skin(1)	5						CAAGGGGCTCCGTGTATTCAG	0.622000													30	28					0	0	0.125774	0	0
EXOSC10	5394	broad.mit.edu	37	1	11159777	11159777	+	Splice_Site	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:11159777C>G	ENST00000544779.1	-	1	117		c.e1+1		RP4-635E18.6_ENST00000447600.1_RNA|EXOSC10_ENST00000376936.4_Splice_Site|EXOSC10_ENST00000304457.7_Splice_Site|RP4-635E18.6_ENST00000435388.1_RNA			Q01780	EXOSX_HUMAN	exosome component 10						CUT catabolic process|histone mRNA catabolic process|maturation of 5.8S rRNA|nuclear polyadenylation-dependent rRNA catabolic process|nuclear retention of unspliced pre-mRNA at the site of transcription|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasm|nuclear exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5' exonuclease activity|exoribonuclease activity|identical protein binding|nucleotide binding|protein serine/threonine kinase activity|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(9)|prostate(1)|stomach(3)|upper_aerodigestive_tract(1)	27	Ovarian(185;0.249)	Lung NSC(185;1.74e-05)|all_lung(284;2.05e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.18e-07)|COAD - Colon adenocarcinoma(227;8.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000315)|Kidney(185;0.000832)|KIRC - Kidney renal clear cell carcinoma(229;0.00269)|READ - Rectum adenocarcinoma(331;0.0526)|STAD - Stomach adenocarcinoma(313;0.202)		CGCGAACTCACCTTCACAAAG	0.706000													22	41					0	0	0.062417	0	0
CYP26B1	56603	broad.mit.edu	37	2	72359511	72359511	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr2:72359511T>C	ENST00000001146.2	-	6	1587	c.1384A>G	c.(1384-1386)Agc>Ggc	p.S462G	CYP26B1_ENST00000546307.1_Missense_Mutation_p.S387G|CYP26B1_ENST00000412253.1_Missense_Mutation_p.S271G	NM_001277742.1|NM_019885.2	NP_001264671.1|NP_063938.1	Q9NR63	CP26B_HUMAN	cytochrome P450, family 26, subfamily B, polypeptide 1	462					cell fate determination|embryonic limb morphogenesis|male meiosis|negative regulation of retinoic acid receptor signaling pathway|proximal/distal pattern formation|retinoic acid catabolic process|spermatogenesis|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			breast(1)|kidney(3)|large_intestine(2)|lung(16)|ovary(2)|prostate(2)|skin(2)	28						TCAAAGCGGCTGGTGCTAGCC	0.647000													17	0					0	0	0.038395	0	0
HTRA4	203100	broad.mit.edu	37	8	38831863	38831863	+	Silent	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr8:38831863C>G	ENST00000302495.4	+	1	181	c.81C>G	c.(79-81)ctC>ctG	p.L27L		NM_153692.3	NP_710159.1	P83105	HTRA4_HUMAN	HtrA serine peptidase 4	27					proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(7)|upper_aerodigestive_tract(1)	11		all_lung(54;0.0344)|Hepatocellular(245;0.0512)|Lung NSC(58;0.0955)	LUSC - Lung squamous cell carcinoma(45;1.5e-07)			TGCCCGTCCTCTGGGCCGGGG	0.711000													18	16					0	0	0.038395	0	0
CAMK1	8536	broad.mit.edu	37	3	9801412	9801412	+	Silent	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr3:9801412C>T	ENST00000256460.3	-	9	945	c.768G>A	c.(766-768)ttG>ttA	p.L256L	OGG1_ENST00000349503.5_Intron|OGG1_ENST00000449570.2_Intron|OGG1_ENST00000383826.5_Intron|OGG1_ENST00000302036.7_Intron|OGG1_ENST00000302008.8_Intron	NM_003656.4	NP_003647.1	Q14012	KCC1A_HUMAN	calcium/calmodulin-dependent protein kinase I	256	Protein kinase.				cell differentiation|nervous system development|positive regulation of muscle cell differentiation|signal transduction	cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)	12	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.0475)		CCTTCTCCATCAAGTGCCGGA	0.522000													82	92					0	0	0.139131	0	0
EPC2	26122	broad.mit.edu	37	2	149519412	149519412	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr2:149519412G>C	ENST00000258484.6	+	5	762	c.728G>C	c.(727-729)aGa>aCa	p.R243T		NM_015630.3	NP_056445.3	Q52LR7	EPC2_HUMAN	enhancer of polycomb homolog 2 (Drosophila)	243					chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.0516)		GAATTTAGTAGAGCCATAACA	0.308000													19	0					0	0	0.049695	0	0
LOXL1	4016	broad.mit.edu	37	15	74219679	74219679	+	Silent	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr15:74219679C>T	ENST00000261921.7	+	1	881	c.555C>T	c.(553-555)gtC>gtT	p.V185V	LOXL1-AS1_ENST00000567257.1_RNA|LOXL1-AS1_ENST00000568087.1_RNA|LOXL1-AS1_ENST00000562965.1_RNA|LOXL1-AS1_ENST00000566675.1_RNA|LOXL1-AS1_ENST00000565416.1_RNA|LOXL1-AS1_ENST00000564963.1_RNA|LOXL1-AS1_ENST00000564194.1_RNA|LOXL1-AS1_ENST00000565756.1_RNA|LOXL1-AS1_ENST00000562739.1_RNA	NM_005576.2	NP_005567.2	Q08397	LOXL1_HUMAN	lysyl oxidase-like 1	185					protein deamination	extracellular space	copper ion binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10						CGCCCTTCGTCAGCCAGTACG	0.736000													53	1					0	0	0.139131	0	0
USP3	9960	broad.mit.edu	37	15	63880588	63880588	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr15:63880588C>A	ENST00000268049.7	+	13	1439	c.1115C>A	c.(1114-1116)tCc>tAc	p.S372Y	USP3-AS1_ENST00000559861.1_RNA|USP3-AS1_ENST00000560962.1_RNA|USP3_ENST00000558218.1_3'UTR|USP3-AS1_ENST00000560350.1_RNA|USP3_ENST00000558285.1_Missense_Mutation_p.S377Y|USP3_ENST00000380324.3_Missense_Mutation_p.S394Y|USP3-AS1_ENST00000559737.1_RNA|USP3_ENST00000559711.1_Missense_Mutation_p.S305Y|USP3-AS1_ENST00000558831.1_RNA|USP3_ENST00000540797.1_Missense_Mutation_p.S350Y|USP3-AS1_ENST00000559357.1_RNA|USP3_ENST00000539772.1_Missense_Mutation_p.S145Y			Q9Y6I4	UBP3_HUMAN	ubiquitin specific peptidase 3	394					DNA repair|histone deubiquitination|mitotic cell cycle|regulation of protein stability|ubiquitin-dependent protein catabolic process	nuclear chromatin	histone binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			endometrium(3)|large_intestine(7)|lung(4)	14				GBM - Glioblastoma multiforme(80;0.0187)		AAACAAAAGTCCACAAAAAAG	0.338000													28	3					9.39395e-14	9.86073e-14	0.116897	1	0
ZBBX	79740	broad.mit.edu	37	3	167023707	167023707	+	Silent	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr3:167023707G>A	ENST00000392766.2	-	17	1789	c.1449C>T	c.(1447-1449)atC>atT	p.I483I	ZBBX_ENST00000455345.2_Silent_p.I483I|ZBBX_ENST00000392764.1_Silent_p.I454I|ZBBX_ENST00000392767.2_Silent_p.I483I|ZBBX_ENST00000307529.5_Silent_p.I483I	NM_001199201.1|NM_024687.3	NP_001186130.1|NP_078963.2	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	483						intracellular	zinc ion binding	p.I483I(2)		NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(9)|liver(1)|lung(38)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	70						CAGGATCCACGATGTTGTCAA	0.284000													7	16					0	0	0.058154	0	0
MALAT1	378938	broad.mit.edu	37	11	65272556	65272556	+	RNA	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr11:65272556G>C	ENST00000534336.1	+	0	7324					NR_002819.2																						GTATTGAATAGATTTCAGCTT	0.413000													36	29					0	0	0.074837	0	0
DCC	1630	broad.mit.edu	37	18	50450225	50450225	+	Silent	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr18:50450225C>G	ENST00000442544.2	+	4	1462	c.846C>G	c.(844-846)ctC>ctG	p.L282L	DCC_ENST00000412726.1_Silent_p.L130L	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	282	Ig-like C2-type 3.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TCATCCAACTCAGGTATTTCA	0.368000													25	22					0	0	0.091800	0	0
MYH4	4622	broad.mit.edu	37	17	10363353	10363353	+	Silent	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr17:10363353G>A	ENST00000255381.2	-	14	1442	c.1332C>T	c.(1330-1332)acC>acT	p.T444T	CTC-297N7.11_ENST00000587182.2_RNA|RP11-799N11.1_ENST00000399342.2_RNA|RP11-799N11.1_ENST00000581304.1_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	444	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						GGTTGATGCGGGTGACCATCC	0.478000													89	5					0	0	0.139131	0	0
MAP3K9	4293	broad.mit.edu	37	14	71216771	71216771	+	Silent	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr14:71216771C>T	ENST00000554752.2	-	4	1028	c.1029G>A	c.(1027-1029)ctG>ctA	p.L343L	MAP3K9_ENST00000555993.2_Silent_p.L343L|MAP3K9_ENST00000381250.4_Silent_p.L343L|MAP3K9_ENST00000554146.1_Silent_p.L80L|MAP3K9_ENST00000553414.1_Silent_p.L37L	NM_001284230.1	NP_001271159.1	P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase 9	343	Protein kinase.				activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(1)|skin(3)|stomach(2)	46				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		CCTCACCAGTCAGCAACTCCC	0.488000													31	38					0	0	0.054565	0	0
ZSCAN22	342945	broad.mit.edu	37	19	58846211	58846211	+	Missense_Mutation	SNP	G	G	C	rs143306274	byFrequency	TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr19:58846211G>C	ENST00000329665.4	+	2	190	c.43G>C	c.(43-45)Gag>Cag	p.E15Q		NM_181846.2	NP_862829.1	P10073	ZSC22_HUMAN	zinc finger and SCAN domain containing 22	15					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|pancreas(1)|prostate(2)	16		all_cancers(17;3.11e-12)|all_epithelial(17;9.43e-09)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0289)		GCCGTGGGAAGAGGACAGCTT	0.617000													21	23					0	0	0.055883	0	0
SNX18	112574	broad.mit.edu	37	5	53815453	53815453	+	Silent	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr5:53815453G>A	ENST00000343017.6	+	1	1865	c.1671G>A	c.(1669-1671)ctG>ctA	p.L557L	SNX18_ENST00000326277.3_Silent_p.L557L|SNX18_ENST00000381410.4_Intron	NM_001145427.1	NP_001138899.1	Q96RF0	SNX18_HUMAN	sorting nexin 18	557	BAR.				cell communication|endocytosis|positive regulation of GTPase activity|protein transport	endomembrane system|endosome membrane|extrinsic to internal side of plasma membrane	phosphatidylinositol binding|protein binding			endometrium(3)|kidney(1)|large_intestine(3)|lung(6)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)	18		Lung NSC(810;3.46e-05)|Breast(144;0.102)				TGTGCAGGCTGAAAGGGGCGA	0.517000													41	55					0	0	0.104719	0	0
TTLL4	9654	broad.mit.edu	37	2	219610931	219610931	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr2:219610931C>T	ENST00000392102.1	+	8	2291	c.1951C>T	c.(1951-1953)Cga>Tga	p.R651*	TTLL4_ENST00000457313.1_Nonsense_Mutation_p.R486*|TTLL4_ENST00000258398.4_Nonsense_Mutation_p.R651*|TTLL4_ENST00000442769.1_Nonsense_Mutation_p.R651*	NM_014640.4	NP_055455.3	Q14679	TTLL4_HUMAN	tubulin tyrosine ligase-like family, member 4	651	TTL.				protein polyglutamylation	cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			endometrium(3)|kidney(1)|large_intestine(6)|lung(21)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	39		Renal(207;0.0915)		Epithelial(149;5.03e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0101)		TCCTAGTTTCCGATCCATTCG	0.542000													62	7					0	0	0.139131	0	0
DLG1	1739	broad.mit.edu	37	3	196778533	196778533	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr3:196778533C>G	ENST00000346964.2	-	25	2778	c.2589G>C	c.(2587-2589)atG>atC	p.M863I	DLG1_ENST00000450955.1_Missense_Mutation_p.M830I|DLG1_ENST00000392382.2_Missense_Mutation_p.M808I|DLG1_ENST00000419354.1_Missense_Mutation_p.M841I|DLG1_ENST00000422288.1_Missense_Mutation_p.M790I|DLG1_ENST00000443183.1_Missense_Mutation_p.M737I|DLG1_ENST00000314062.3_Missense_Mutation_p.M790I|DLG1_ENST00000357674.4_Missense_Mutation_p.M830I|DLG1_ENST00000452595.1_Missense_Mutation_p.M725I|DLG1_ENST00000448528.2_Missense_Mutation_p.M841I	NM_004087.2	NP_004078.2	Q12959	DLG1_HUMAN	discs, large homolog 1 (Drosophila)	841	Guanylate kinase-like.				actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|MPP7-DLG1-LIN7 complex|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	cytoskeletal protein binding|guanylate kinase activity|L27 domain binding|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein binding|protein C-terminus binding|protein kinase binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|liver(1)|lung(9)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	26	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)		GACGCTTATTCATTTCCCTAC	0.328000													34	33					0	0	0.064281	0	0
TAS1R3	83756	broad.mit.edu	37	1	1267072	1267072	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:1267072G>C	ENST00000339381.5	+	2	278	c.246G>C	c.(244-246)gaG>gaC	p.E82D		NM_152228.1	NP_689414	Q7RTX0	TS1R3_HUMAN	taste receptor, type 1, member 3	82					detection of chemical stimulus involved in sensory perception of sweet taste|sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			kidney(2)|lung(8)|upper_aerodigestive_tract(1)|urinary_tract(1)	12	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.88e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.146)	Aspartame(DB00168)	CCGTGGAGGAGATCAACAACA	0.622000													20	61					0	0	0.043863	0	0
CTNNA2	1496	broad.mit.edu	37	2	80773162	80773162	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr2:80773162C>T	ENST00000466387.1	+	15	2238	c.1514C>T	c.(1513-1515)tCa>tTa	p.S505L	CTNNA2_ENST00000541047.1_Missense_Mutation_p.S505L|CTNNA2_ENST00000540488.1_Missense_Mutation_p.S505L|CTNNA2_ENST00000343114.3_Missense_Mutation_p.S184L|CTNNA2_ENST00000361291.4_Missense_Mutation_p.S539L|CTNNA2_ENST00000402739.4_Missense_Mutation_p.S505L|CTNNA2_ENST00000496558.1_Missense_Mutation_p.S505L			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	505					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton	p.S505*(1)		breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						GACATCACCTCAGTGGATGAC	0.512000													12	0					0	0	0.105934	0	0
TMPRSS12	283471	broad.mit.edu	37	12	51279033	51279033	+	Silent	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr12:51279033C>T	ENST00000551456.1	+	4	702	c.657C>T	c.(655-657)aaC>aaT	p.N219N	TMPRSS12_ENST00000398458.3_Silent_p.N219N			Q86WS5	TMPSC_HUMAN	transmembrane (C-terminal) protease, serine 12	219	Peptidase S1.				proteolysis	integral to membrane	serine-type endopeptidase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	18						TAACAGGTAACGCTACAAATA	0.318000													32	46					0	0	0.144211	0	0
PDE4A	5141	broad.mit.edu	37	19	10572652	10572652	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr19:10572652G>C	ENST00000380702.2	+	14	1654	c.1654G>C	c.(1654-1656)Gat>Cat	p.D552H	PDE4A_ENST00000592685.1_Missense_Mutation_p.D552H|PDE4A_ENST00000344979.3_Missense_Mutation_p.D335H|PDE4A_ENST00000440014.2_Missense_Mutation_p.D513H|PDE4A_ENST00000352831.6_Missense_Mutation_p.D574H|PDE4A_ENST00000293683.5_Missense_Mutation_p.D548H			P27815	PDE4A_HUMAN	phosphodiesterase 4A, cAMP-specific	574	Catalytic.				signal transduction	cytosol|membrane fraction|perinuclear region of cytoplasm|ruffle membrane|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	27			OV - Ovarian serous cystadenocarcinoma(20;5.8e-10)|Epithelial(33;7.58e-07)|all cancers(31;3.91e-06)		Cilostazol(DB01166)|Dipyridamole(DB00975)|Dyphylline(DB00651)|Enprofylline(DB00824)|Iloprost(DB01088)|Milrinone(DB00235)|Pentoxifylline(DB00806)|Phentolamine(DB00692)|Tadalafil(DB00820)|Theophylline(DB00277)	CCTCCTGCTAGATAACTACTC	0.597000													41	62					0	0	0.124865	0	0
TSTD2	158427	broad.mit.edu	37	9	100373977	100373977	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr9:100373977C>T	ENST00000341170.4	-	5	990	c.608G>A	c.(607-609)cGa>cAa	p.R203Q	TSTD2_ENST00000484708.1_5'UTR|TSTD2_ENST00000354801.2_Intron	NM_139246.4	NP_640339.4	Q5T7W7	TSTD2_HUMAN	thiosulfate sulfurtransferase (rhodanese)-like domain containing 2	203										large_intestine(3)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	15						TGCAGCAATTCGAATCTGAGA	0.413000													40	1					0	0	0.117977	0	0
BRAF	673	broad.mit.edu	37	7	140534527	140534527	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr7:140534527G>A	ENST00000288602.6	-	3	446	c.386C>T	c.(385-387)tCa>tTa	p.S129L		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	129	Poly-Ser.				activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding		SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	AGGTAGCACTGAAAGGCTAGA	0.443000		61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				26	43					0	0	0.091800	0	0
CNST	163882	broad.mit.edu	37	1	246810748	246810748	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr1:246810748G>C	ENST00000366513.4	+	9	1514	c.1245G>C	c.(1243-1245)gaG>gaC	p.E415D	CNST_ENST00000483271.1_3'UTR|CNST_ENST00000366512.3_Missense_Mutation_p.E415D	NM_152609.2	NP_689822.2	Q6PJW8	CNST_HUMAN	consortin, connexin sorting protein	415					positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|urinary_tract(2)	28						CCAGAATAGAGGGCATTGCTG	0.532000											OREG0014367	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	110	124					0	0	0.139131	0	0
ATP9B	374868	broad.mit.edu	37	18	77089266	77089266	+	Silent	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr18:77089266C>T	ENST00000426216.2	+	16	1916	c.1899C>T	c.(1897-1899)ttC>ttT	p.F633F	ATP9B_ENST00000307671.7_Silent_p.F633F	NM_198531.3	NP_940933.3	O43861	ATP9B_HUMAN	ATPase, class II, type 9B	633					ATP biosynthetic process	integral to membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(3)|prostate(1)|skin(2)|stomach(1)	38		Esophageal squamous(42;0.018)|Melanoma(33;0.0964)|Prostate(75;0.171)		OV - Ovarian serous cystadenocarcinoma(15;1.44e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0405)		TGTTTCCCTTCACCTCCGAGA	0.587000													57	55					0	0	0.139131	0	0
GPR18	2841	broad.mit.edu	37	13	99907920	99907920	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr13:99907920C>G	ENST00000340807.3	-	3	763	c.207G>C	c.(205-207)ttG>ttC	p.L69F	GPR18_ENST00000397473.2_Missense_Mutation_p.L69F|GPR18_ENST00000397470.2_Missense_Mutation_p.L69F|UBAC2_ENST00000376440.2_Intron|UBAC2_ENST00000403766.3_Intron			Q14330	GPR18_HUMAN	G protein-coupled receptor 18	69						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(2)|large_intestine(2)|lung(6)	10	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Glycine(DB00145)	TTATAAATATCAAGTCCACTA	0.373000													26	61					0	0	0.099896	0	0
NLRP14	338323	broad.mit.edu	37	11	7064529	7064529	+	Silent	SNP	G	G	A			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr11:7064529G>A	ENST00000299481.4	+	4	1618	c.1272G>A	c.(1270-1272)ctG>ctA	p.L424L		NM_176822.3	NP_789792.1	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	424	NACHT.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			breast(3)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	21				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		AAGCCCAGCTGAGAAGACTGT	0.458000													68	72					0	0	0.139131	0	0
CYP2B6	1555	broad.mit.edu	37	19	41512931	41512931	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr19:41512931C>G	ENST00000324071.4	+	4	613	c.606C>G	c.(604-606)ttC>ttG	p.F202L	CYP2B6_ENST00000593831.1_Intron|CYP2B6_ENST00000330446.5_Intron|CYP2B6_ENST00000598834.1_3'UTR	NM_000767.4	NP_000758.1	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B, polypeptide 6	202					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding	p.F202L(1)		NS(1)|breast(1)|endometrium(5)|kidney(1)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	28			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	TGAACTTGTTCTACCAGACTT	0.512000													61	90					0	0	0.139131	0	0
DMXL1	1657	broad.mit.edu	37	5	118469494	118469494	+	Silent	SNP	C	C	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr5:118469494C>T	ENST00000311085.8	+	12	1955	c.1875C>T	c.(1873-1875)ctC>ctT	p.L625L	DMXL1_ENST00000539542.1_Silent_p.L625L	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	625										breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		CTACTGTTCTCAGTATTTCCC	0.378000													29	38					0	0	0.134883	0	0
PKD2L2	27039	broad.mit.edu	37	5	137275811	137275812	+	Frame_Shift_Ins	INS	-	-	T			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr5:137275811_137275812insT	ENST00000290431.5	+	14	1840_1841	c.1817_1818insT	c.(1816-1821)tctgagfs	p.E607fs	PKD2L2_ENST00000508638.1_3'UTR|PKD2L2_ENST00000502810.1_3'UTR|FAM13B_ENST00000033079.3_3'UTR|PKD2L2_ENST00000508883.1_Intron	NM_014386.3	NP_055201.2	Q9NZM6	PK2L2_HUMAN	polycystic kidney disease 2-like 2	0						integral to membrane	calcium ion binding|ion channel activity			breast(1)|endometrium(7)|kidney(4)|large_intestine(6)|lung(7)|skin(1)|upper_aerodigestive_tract(2)	28			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			ATGAGATTCTCTGAGTGCCTGA	0.391													35	34	---	---	---	---					
C11orf49	79096	broad.mit.edu	37	11	47182742	47182742	+	Frame_Shift_Del	DEL	G	G	-	rs34737621		TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr11:47182742delG	ENST00000395460.2	+	8	860	c.822delG	c.(820-822)ctgfs	p.L274fs	C11orf49_ENST00000378618.2_Splice_Site|C11orf49_ENST00000536126.1_Splice_Site|C11orf49_ENST00000278460.7_Splice_Site|C11orf49_ENST00000378615.3_Splice_Site|C11orf49_ENST00000543718.1_Splice_Site	NM_001003676.1	NP_001003676.1	Q9H6J7	CK049_HUMAN	chromosome 11 open reading frame 49	274										central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|skin(1)	11						TGGAACGGCTGTAAGTGTCAA	0.572											OREG0020950	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	41	49	---	---	---	---					
TRIM51	84767	broad.mit.edu	37	11	55653610	55653610	+	Frame_Shift_Del	DEL	A	A	-			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr11:55653610delA	ENST00000449290.2	+	3	515	c.423delA	c.(421-423)ctafs	p.L141fs	TRIM51_ENST00000244891.3_5'UTR	NM_032681.3	NP_116070.2	Q9BSJ1	SPRY5_HUMAN	tripartite motif-containing 51	141						intracellular	zinc ion binding										AGGAGCTCCTAAAAAAAATGC	0.403													11	30	---	---	---	---					
DDX28	55794	broad.mit.edu	37	16	68056722	68056722	+	Frame_Shift_Del	DEL	A	A	-			TCGA-G2-A2EL-01A-12D-A18F-08	TCGA-G2-A2EL-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	56924619-0724-4b3e-9c53-27c27d3789d6	1f537274-6e2a-4bba-bfa9-2b08de1e3658	g.chr16:68056722delA	ENST00000332395.5	-	1	1048	c.384delT	c.(382-384)tttfs	p.F128fs		NM_018380.3	NP_060850.2	Q9NUL7	DDX28_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 28	128						mitochondrial nucleoid|nucleus	ATP binding|ATP-dependent helicase activity|RNA binding			central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	13		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0116)|Epithelial(162;0.0474)|all cancers(182;0.233)		CCAGGTCAGCAAAGCTGCCCT	0.647													9	20	---	---	---	---