Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
DCHS1	8642	broad.mit.edu	37	11	6655409	6655409	+	Silent	SNP	C	C	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr11:6655409C>A	ENST00000299441.3	-	3	2337	c.1926G>T	c.(1924-1926)cgG>cgT	p.R642R	RP11-732A19.6_ENST00000526633.1_RNA	NM_003737.2	NP_003728.1	Q96JQ0	PCD16_HUMAN	dachsous cadherin-related 1	642	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(16)|liver(1)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	103		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGTCCAGGGTCCGGGTTGTGC	0.582000													20	71					7.45023e-12	8.30168e-12	1	1	0
PABPC1L	80336	broad.mit.edu	37	20	43541300	43541300	+	Splice_Site	SNP	G	G	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr20:43541300G>A	ENST00000255136.3	+	2	275		c.e2-1		PABPC1L_ENST00000537323.1_Splice_Site|PABPC1L_ENST00000217073.2_Splice_Site|PABPC1L_ENST00000217074.4_Splice_Site	NM_001124756.1	NP_001118228.1	Q4VXU2	PAP1L_HUMAN	poly(A) binding protein, cytoplasmic 1-like								nucleotide binding|RNA binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	20						CTTCTGTCCAGCGGAGCGGGC	0.502000													4	65					0	0	1	0	0
CLCN2	1181	broad.mit.edu	37	3	184075861	184075861	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr3:184075861C>G	ENST00000265593.4	-	5	675	c.504G>C	c.(502-504)aaG>aaC	p.K168N	CLCN2_ENST00000434054.2_Missense_Mutation_p.K124N|CLCN2_ENST00000457512.1_Missense_Mutation_p.K168N|EIF2B5_ENST00000444495.1_Intron|CLCN2_ENST00000423355.2_5'UTR|CLCN2_ENST00000344937.7_Missense_Mutation_p.K168N	NM_004366.5	NP_004357.3	P51788	CLCN2_HUMAN	chloride channel, voltage-sensitive 2	168						chloride channel complex	voltage-gated chloride channel activity			breast(2)|central_nervous_system(4)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	27	all_cancers(143;6.66e-11)|Ovarian(172;0.0339)		Epithelial(37;2.22e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Lubiprostone(DB01046)	GCAAGATGGTCTTCATCTCAG	0.577000													49	85					0	0	1	0	0
GMDS	2762	broad.mit.edu	37	6	2117711	2117711	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr6:2117711A>G	ENST00000380815.4	-	3	496	c.227T>C	c.(226-228)aTt>aCt	p.I76T	GMDS_ENST00000530927.1_Missense_Mutation_p.I46T	NM_001500.3	NP_001491.1	O60547	GMDS_HUMAN	GDP-mannose 4,6-dehydratase	76					'de novo' GDP-L-fucose biosynthetic process|GDP-mannose metabolic process|leukocyte cell-cell adhesion		coenzyme binding|GDP-mannose 4,6-dehydratase activity		GMDS/PDE8B(2)	breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(2)|lung(8)|prostate(1)	21	Ovarian(93;0.0733)	all_cancers(2;7.64e-19)|all_epithelial(2;3.05e-16)|Colorectal(2;0.00414)|all_hematologic(90;0.00997)|all_lung(73;0.0141)|Lung NSC(90;0.0802)		Epithelial(2;7.61e-06)|all cancers(2;0.000111)|STAD - Stomach adenocarcinoma(2;0.000231)|Colorectal(2;0.00445)|COAD - Colon adenocarcinoma(2;0.0125)|OV - Ovarian serous cystadenocarcinoma(45;0.0563)		ACTTCCTTCAATGTGAGCCTG	0.373000													27	42					0	0	1	0	0
DCHS1	8642	broad.mit.edu	37	11	6643058	6643058	+	Silent	SNP	G	G	A	rs148587402		TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr11:6643058G>A	ENST00000299441.3	-	21	10260	c.9849C>T	c.(9847-9849)agC>agT	p.S3283S	RP11-732A19.5_ENST00000526456.1_RNA	NM_003737.2	NP_003728.1	Q96JQ0	PCD16_HUMAN	dachsous cadherin-related 1	3283					calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(16)|liver(1)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	103		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAGACTCTGCGCTGAGTGCTG	0.647000													4	10					0	0	1	0	0
IGHV1OR16-3	28313	broad.mit.edu	37	16	32070612	32070612	+	RNA	SNP	A	A	C			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr16:32070612A>C	ENST00000566806.1	-	0	499																											GGTCTCCTGCAAGGCTTCTGG	0.552000													3	70					0	0	1	0	0
PRR5	55615	broad.mit.edu	37	22	45133115	45133115	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr22:45133115G>T	ENST00000403581.1	+	10	1833	c.1224G>T	c.(1222-1224)caG>caT	p.Q408H	PRR5_ENST00000336985.6_Missense_Mutation_p.Q385H|ARHGAP8_ENST00000517296.3_Intron|PRR5-ARHGAP8_ENST00000352766.7_Intron|PRR5-ARHGAP8_ENST00000361473.5_Intron|PRR5_ENST00000006251.7_Missense_Mutation_p.Q376H|ARHGAP8_ENST00000389773.5_Intron	NM_001198721.1	NP_001185650.1			proline rich 5 (renal)									p.Q408H(1)|p.Q385H(1)		central_nervous_system(1)|endometrium(2)|lung(6)|prostate(1)|skin(1)	11		all_neural(38;0.00409)|Ovarian(80;0.024)|Glioma(61;0.0647)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)		GGGGCCGGCAGAGTGTCGTGT	0.587000													16	41					1.99824e-07	2.16476e-07	1	1	0
KY	339855	broad.mit.edu	37	3	134323201	134323201	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr3:134323201C>A	ENST00000508956.1	-	10	1200	c.1143G>T	c.(1141-1143)ttG>ttT	p.L381F	KY_ENST00000423778.2_Missense_Mutation_p.L402F|KY_ENST00000503669.1_3'UTR			Q8NBH2	KY_HUMAN	kyphoscoliosis peptidase	402						cytoskeleton|Z disc	peptidase activity			central_nervous_system(1)|endometrium(3)|kidney(1)|lung(12)|ovary(2)|upper_aerodigestive_tract(2)	21						GGTACACCTCCAACTTCATCC	0.547000													15	44					0.000219431	0.000225206	1	1	0
KIAA1755	85449	broad.mit.edu	37	20	36869030	36869030	+	Nonsense_Mutation	SNP	A	A	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr20:36869030A>T	ENST00000279024.4	-	3	1774	c.1503T>A	c.(1501-1503)tgT>tgA	p.C501*		NM_001029864.1	NP_001025035.1	Q5JYT7	K1755_HUMAN	KIAA1755	501										breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(5)|pancreas(2)|skin(4)|stomach(1)	54		Myeloproliferative disorder(115;0.00874)				AGTAGAGGGAACACAGGACTT	0.522000													6	158					0	0	1	0	0
MINK1	50488	broad.mit.edu	37	17	4796013	4796013	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr17:4796013C>G	ENST00000355280.6	+	19	2457	c.2261C>G	c.(2260-2262)tCt>tGt	p.S754C	MINK1_ENST00000453408.3_Missense_Mutation_p.S734C|MINK1_ENST00000347992.7_Missense_Mutation_p.S717C	NM_001024937.3|NM_015716.4|NM_153827.4	NP_001020108.1|NP_056531.1|NP_722549.2	Q8N4C8	MINK1_HUMAN	misshapen-like kinase 1	754					JNK cascade	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)|stomach(1)	6						CTTCCAGCCTCTCACGGGCAC	0.682000													12	41					0	0	1	0	0
EPT1	85465	broad.mit.edu	37	2	26596256	26596256	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr2:26596256C>G	ENST00000260585.7	+	5	451	c.332C>G	c.(331-333)gCt>gGt	p.A111G		NM_033505.2	NP_277040.1	Q9C0D9	EPT1_HUMAN	ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)	111					phospholipid biosynthetic process	integral to membrane	ethanolaminephosphotransferase activity|metal ion binding										GGAAAGCAAGCTCGCAGAACC	0.423000													3	23					0	0	1	0	0
ATP1A4	480	broad.mit.edu	37	1	160151813	160151813	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr1:160151813C>A	ENST00000368081.4	+	20	3432	c.2961C>A	c.(2959-2961)taC>taA	p.Y987*	ATP1A4_ENST00000418334.1_3'UTR|ATP1A4_ENST00000470705.1_Nonsense_Mutation_p.Y123*	NM_144699.3	NP_653300.2	Q13733	AT1A4_HUMAN	ATPase, Na+/K+ transporting, alpha 4 polypeptide	987					ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(34)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	75	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TGCGAATGTACCCACTCAAGT	0.522000													33	85					8.73648e-17	9.90473e-17	1	1	0
NCF2	4688	broad.mit.edu	37	1	183534894	183534894	+	Silent	SNP	G	G	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr1:183534894G>A	ENST00000413720.1	-	9	1084	c.810C>T	c.(808-810)tcC>tcT	p.S270S	NCF2_ENST00000418089.1_Silent_p.S234S|NCF2_ENST00000367536.1_Silent_p.S315S|NCF2_ENST00000367535.3_Silent_p.S315S	NM_001190794.1	NP_001177723.1	P19878	NCF2_HUMAN	neutrophil cytosolic factor 2	315	SH3 1.				cellular defense response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex|nucleolus	electron carrier activity|protein C-terminus binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	30						CTGGGATGTCGGACTGCGGAG	0.592000													26	75					0	0	1	0	0
RP11-252A24.2	0	broad.mit.edu	37	16	74372644	74372644	+	RNA	SNP	A	A	G			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr16:74372644A>G	ENST00000429810.2	-	0	1552																											TACCCTTGTCAGGGGGAACAA	0.443000													3	34					0	0	1	0	0
MROH5	389690	broad.mit.edu	37	8	142446032	142446032	+	RNA	SNP	T	T	C			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr8:142446032T>C	ENST00000606664.1	+	0	1388				MROH5_ENST00000430863.1_RNA																							AGCTGGGCATTGGTCCTTCAG	0.672000													5	51					0	0	1	0	0
TNFSF15	9966	broad.mit.edu	37	9	117552903	117552903	+	Silent	SNP	G	G	C			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr9:117552903G>C	ENST00000374045.4	-	4	698	c.585C>G	c.(583-585)ctC>ctG	p.L195L	TNFSF15_ENST00000374044.1_Silent_p.L118L	NM_001204344.1|NM_005118.3	NP_001191273.1|NP_005109.2	O95150	TNF15_HUMAN	tumor necrosis factor (ligand) superfamily, member 15	195					activation of caspase activity|activation of NF-kappaB-inducing kinase activity|cytokine metabolic process|immune response	extracellular space|integral to plasma membrane	cytokine activity|tumor necrosis factor receptor binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|skin(1)	11						TGGTCCCCATGAGGAGCTGGG	0.532000													10	16					0	0	1	0	0
C3orf72	401089	broad.mit.edu	37	3	138669110	138669110	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr3:138669110C>T	ENST00000383165.3	+	3	355	c.224C>T	c.(223-225)cCg>cTg	p.P75L		NM_001040061.2	NP_001035150.1	Q6ZUU3	CC072_HUMAN	chromosome 3 open reading frame 72	75										large_intestine(1)|lung(3)	4						TCCCCAGGGCCGGGAATCCTG	0.706000													17	34					0	0	1	0	0
EIF3H	8667	broad.mit.edu	37	8	117661114	117661114	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr8:117661114C>G	ENST00000521861.1	-	6	782	c.759G>C	c.(757-759)atG>atC	p.M253I	EIF3H_ENST00000276682.4_Missense_Mutation_p.M267I	NM_003756.2	NP_003747.1	O15372	EIF3H_HUMAN	eukaryotic translation initiation factor 3, subunit H	253					regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			large_intestine(2)|lung(10)|skin(1)	13	all_cancers(13;3.98e-22)|Lung NSC(37;0.000183)|Ovarian(258;0.0172)					TATCTTGGCTCATTTCATCCA	0.343000													20	43					0	0	1	0	0
SLC39A12	221074	broad.mit.edu	37	10	18276475	18276475	+	Silent	SNP	C	C	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr10:18276475C>T	ENST00000377369.2	+	7	1437	c.1164C>T	c.(1162-1164)gtC>gtT	p.V388V	SLC39A12_ENST00000377371.3_Silent_p.V388V|SLC39A12_ENST00000539911.1_Silent_p.V254V|SLC39A12_ENST00000377374.4_Silent_p.V388V	NM_001145195.1|NM_001282733.1|NM_001282734.1	NP_001138667.1|NP_001269662.1|NP_001269663.1	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter), member 12	388					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|kidney(3)|large_intestine(5)|lung(38)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	60						CAGCGCTGGTCCTTTTCCATA	0.547000													7	112					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40392611	40392611	+	Silent	SNP	C	C	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr19:40392611C>T	ENST00000221347.6	-	16	7900	c.7893G>A	c.(7891-7893)ccG>ccA	p.P2631P		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	2631	VWFD 6.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			AGGTGGGCGGCGGCAGGCAGG	0.647000													5	45					0	0	1	0	0
PCDHA12	56137	broad.mit.edu	37	5	140255135	140255135	+	Silent	SNP	G	G	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr5:140255135G>T	ENST00000398631.2	+	1	78	c.78G>T	c.(76-78)gtG>gtT	p.V26V	PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron	NM_018903.2|NM_031864.2	NP_061726.1|NP_114070.1														NS(4)|breast(2)|cervix(1)|endometrium(19)|kidney(8)|large_intestine(8)|liver(2)|lung(25)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTGGGAGGTGGGGAGCGGCC	0.642000													12	50					2.80697e-09	3.07506e-09	1	1	0
RNF123	63891	broad.mit.edu	37	3	49735549	49735549	+	Silent	SNP	C	C	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr3:49735549C>T	ENST00000327697.6	+	7	606	c.462C>T	c.(460-462)atC>atT	p.I154I	RNF123_ENST00000432042.1_Silent_p.I8I	NM_022064.3	NP_071347.2	Q5XPI4	RN123_HUMAN	ring finger protein 123	154	B30.2/SPRY.					cytoplasm	ligase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		GGTGCACCATCAGCTGCCGCT	0.617000													28	50					0	0	1	0	0
PCDHGB4	8641	broad.mit.edu	37	5	140769234	140769234	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr5:140769234G>C	ENST00000519479.1	+	1	1783	c.1783G>C	c.(1783-1785)Gac>Cac	p.D595H	PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron	NM_003736.2|NM_018925.2|NM_032098.1	NP_003727.1|NP_061748.1|NP_115269.1														endometrium(9)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|prostate(1)|stomach(3)|urinary_tract(2)	37			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGGACGCAGACTCAGGACA	0.677000													6	48					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21101749	21101749	+	Missense_Mutation	SNP	C	C	G	rs146601168		TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr10:21101749C>G	ENST00000377122.4	-	24	2863	c.2467G>C	c.(2467-2469)Ggg>Cgg	p.G823R	NEBL_ENST00000417816.2_Missense_Mutation_p.G160R|NEBL_ENST00000377159.4_Missense_Mutation_p.G126R	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	823					regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						GGGTGGACCCCTTTATAGGCA	0.532000													9	58					0	0	1	0	0
TMPRSS13	84000	broad.mit.edu	37	11	117787898	117787898	+	Silent	SNP	C	C	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr11:117787898C>T	ENST00000526090.1	-	3	694	c.543G>A	c.(541-543)tcG>tcA	p.S181S	TMPRSS13_ENST00000524993.1_Silent_p.S181S|TMPRSS13_ENST00000430170.2_Silent_p.S181S|TMPRSS13_ENST00000528626.1_Intron|TMPRSS13_ENST00000445164.2_Silent_p.S181S	NM_001206790.1	NP_001193719.1	Q9BYE2	TMPSD_HUMAN	transmembrane protease, serine 13	176					proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			endometrium(1)|kidney(3)|large_intestine(6)|lung(7)|pancreas(1)|prostate(1)|urinary_tract(1)	20	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.00106)		GGATGATGAGCGAAACCACCA	0.637000													9	39					0	0	1	0	0
KIAA1683	80726	broad.mit.edu	37	19	18377615	18377615	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr19:18377615G>C	ENST00000392413.4	-	3	950	c.735C>G	c.(733-735)atC>atG	p.I245M	KIAA1683_ENST00000600359.3_Missense_Mutation_p.I199M|KIAA1683_ENST00000600328.3_Missense_Mutation_p.I245M	NM_001145304.1	NP_001138776.1	Q9H0B3	K1683_HUMAN	KIAA1683							mitochondrion				breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						AGGGAAATCTGATGGTGACCG	0.617000													22	57					0	0	1	0	0
OPHN1	4983	broad.mit.edu	37	X	67283838	67283838	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chrX:67283838C>A	ENST00000355520.5	-	21	2657	c.2016G>T	c.(2014-2016)aaG>aaT	p.K672N	OPHN1_ENST00000484842.1_5'UTR|OPHN1_ENST00000540071.1_Intron	NM_002547.2	NP_002538.1	O60890	OPHN1_HUMAN	oligophrenin 1	672	Pro-rich.				axon guidance|endocytosis|filopodium assembly|small GTPase mediated signal transduction|substrate-dependent cell migration, cell extension	axon|cell junction|cytosol|dendritic spine|synapse	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(3)|skin(2)	31						TAGACACCAACTTCCCCACGT	0.587000													10	72					2.17888e-05	2.28431e-05	1	1	0
PATL1	219988	broad.mit.edu	37	11	59406552	59406552	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr11:59406552G>A	ENST00000300146.9	-	18	2344	c.2260C>T	c.(2260-2262)Cag>Tag	p.Q754*	AP000442.1_ENST00000531108.1_RNA|AP000442.1_ENST00000531311.1_RNA	NM_152716.2	NP_689929.2	Q86TB9	PATL1_HUMAN	protein associated with topoisomerase II homolog 1 (yeast)	754	Region C.				cytoplasmic mRNA processing body assembly|deadenylation-dependent decapping of nuclear-transcribed mRNA	cytoplasmic mRNA processing body	protein binding|RNA binding			central_nervous_system(1)|endometrium(2)|lung(5)|ovary(1)|prostate(2)	11						TTCAGTTTCTGCCGGTCAACA	0.473000													11	36					0	0	1	0	0
MROH5	389690	broad.mit.edu	37	8	142446033	142446033	+	RNA	SNP	G	G	C			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr8:142446033G>C	ENST00000606664.1	+	0	1389				MROH5_ENST00000430863.1_RNA																							GCTGGGCATTGGTCCTTCAGG	0.672000													5	51					0	0	1	0	0
AHCY	191	broad.mit.edu	37	20	32880237	32880237	+	Silent	SNP	G	G	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr20:32880237G>A	ENST00000538132.1	-	4	674	c.288C>T	c.(286-288)ccC>ccT	p.P96P	AHCY_ENST00000217426.2_Silent_p.P124P|AHCY_ENST00000468908.1_5'UTR	NM_001161766.1	NP_001155238.1	P23526	SAHH_HUMAN	adenosylhomocysteinase	124					methylation|xenobiotic metabolic process	cytosol|melanosome	adenosylhomocysteinase activity|protein binding			endometrium(6)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19						TCATGTTGAGGGGCCCGTCCT	0.617000													18	89					0	0	1	0	0
DTNBP1	84062	broad.mit.edu	37	6	15627647	15627647	+	Silent	SNP	G	G	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr6:15627647G>A	ENST00000338950.5	-	5	387	c.282C>T	c.(280-282)ctC>ctT	p.L94L	DTNBP1_ENST00000344537.5_Silent_p.L94L|DTNBP1_ENST00000355917.3_Silent_p.L94L	NM_183040.2	NP_898861.1	Q96EV8	DTBP1_HUMAN	dystrobrevin binding protein 1	94					actin cytoskeleton reorganization|cellular membrane organization|neuron projection morphogenesis|post-Golgi vesicle-mediated transport|regulation of dopamine receptor signaling pathway	axon part|BLOC-1 complex|cell junction|dendritic spine|endoplasmic reticulum membrane|endosome membrane|growth cone|melanosome membrane|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|synaptic vesicle membrane|synaptosome	identical protein binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)|ovary(1)|skin(2)	14	Breast(50;0.0289)|Ovarian(93;0.103)	all_hematologic(90;0.0895)	Epithelial(50;0.211)			GCAGCTCCACGAGGCTTGTCT	0.483000									Hermansky-Pudlak syndrome				10	44					0	0	1	0	0
FBXO15	201456	broad.mit.edu	37	18	71740847	71740847	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr18:71740847C>A	ENST00000269500.5	-	10	1489	c.1154G>T	c.(1153-1155)gGa>gTa	p.G385V	FBXO15_ENST00000419743.2_Missense_Mutation_p.G461V|FBXO15_ENST00000580806.1_5'UTR	NM_152676.2	NP_689889.1	Q8NCQ5	FBX15_HUMAN	F-box protein 15	385										autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)	27		Esophageal squamous(42;0.103)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.143)		GTATGTCTGTCCCAAGAAGCT	0.512000													40	205					6.5261e-18	7.48582e-18	1	1	0
IRX1	79192	broad.mit.edu	37	5	3599660	3599660	+	Missense_Mutation	SNP	C	C	A	rs143830823	byFrequency	TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr5:3599660C>A	ENST00000302006.3	+	2	650	c.598C>A	c.(598-600)Cag>Aag	p.Q200K	CTD-2012M11.3_ENST00000559410.1_RNA	NM_024337.3	NP_077313.3	P78414	IRX1_HUMAN	iroquois homeobox 1	200						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|endometrium(5)|kidney(2)|large_intestine(5)|lung(18)|ovary(2)|pancreas(1)|prostate(5)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	43						CAGCAAGGACCAGGAAGATGG	0.622000													13	43					4.3838e-07	4.72288e-07	1	1	0
SPTAN1	6709	broad.mit.edu	37	9	131348125	131348125	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr9:131348125G>T	ENST00000358161.5	+	19	2772	c.2659G>T	c.(2659-2661)Gag>Tag	p.E887*	SPTAN1_ENST00000372739.3_Nonsense_Mutation_p.E887*|SPTAN1_ENST00000372731.4_Nonsense_Mutation_p.E887*			Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	887					actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			NS(2)|breast(8)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(21)|liver(1)|lung(25)|ovary(5)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	87						GCAGGACCTGGAGGACTCTCT	0.557000													34	52					4.3181e-19	4.98242e-19	1	1	0
VPS33A	65082	broad.mit.edu	37	12	122750907	122750907	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr12:122750907C>T	ENST00000267199.4	-	1	161	c.49G>A	c.(49-51)Gag>Aag	p.E17K	RP11-512M8.5_ENST00000535844.1_Missense_Mutation_p.E17K|VPS33A_ENST00000451053.2_Missense_Mutation_p.E17K	NM_022916.4	NP_075067.2	Q96AX1	VP33A_HUMAN	vacuolar protein sorting 33 homolog A (S. cerevisiae)	17					lysosome localization|melanosome localization|platelet formation|protein transport|regulation of developmental pigmentation|vesicle docking involved in exocytosis	early endosome|late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(13)|ovary(1)|skin(2)	28	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000336)|Epithelial(86;0.000606)|BRCA - Breast invasive adenocarcinoma(302;0.23)		CGCACCGCCTCGCGCAACACG	0.677000													15	54					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77763390	77763390	+	Silent	SNP	G	G	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr8:77763390G>A	ENST00000521891.2	+	10	4681	c.4233G>A	c.(4231-4233)aaG>aaA	p.K1411K	ZFHX4_ENST00000518282.1_Silent_p.K1385K|ZFHX4_ENST00000455469.2_Silent_p.K1366K|ZFHX4_ENST00000050961.6_Silent_p.K1366K	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	1366						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CTATGCAGAAGCTTCAGATAC	0.438000										HNSCC(33;0.089)			6	23					0	0	1	0	0
PCDH20	64881	broad.mit.edu	37	13	61986173	61986173	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr13:61986173T>C	ENST00000409186.1	-	5	4164	c.2059A>G	c.(2059-2061)Ata>Gta	p.I687V	PCDH20_ENST00000409204.4_Missense_Mutation_p.I687V			Q8N6Y1	PCD20_HUMAN	protocadherin 20	660	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(14)|liver(1)|lung(23)|ovary(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	58		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		CCTGTATCTATGACAAAAATA	0.478000													38	62					0	0	1	0	0
LRRC24	441381	broad.mit.edu	37	8	145747933	145747933	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr8:145747933C>T	ENST00000529415.2	-	5	1585	c.1468G>A	c.(1468-1470)Gac>Aac	p.D490N	LRRC14_ENST00000292524.1_3'UTR|LRRC24_ENST00000533758.1_Missense_Mutation_p.D487N			Q50LG9	LRC24_HUMAN	leucine rich repeat containing 24	490						integral to membrane				breast(2)|endometrium(1)|kidney(1)|lung(1)	5	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			GGGCCGCAGTCAGCGGGCGCC	0.741000													3	4					0	0	1	0	0
GIMAP8	155038	broad.mit.edu	37	7	150164244	150164244	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr7:150164244C>G	ENST00000307271.3	+	2	1032	c.458C>G	c.(457-459)cCt>cGt	p.P153R		NM_175571.2	NP_783161.1	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	153						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		AAAAACAAACCTCTCAAGCAG	0.448000													7	193					0	0	1	0	0
PPAN-P2RY11	692312	broad.mit.edu	37	19	10221670	10221670	+	Silent	SNP	G	G	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr19:10221670G>A	ENST00000428358.1	+	12	1423	c.1251G>A	c.(1249-1251)cgG>cgA	p.R417R	PPAN-P2RY11_ENST00000393796.4_Silent_p.R417R|PPAN_ENST00000393793.1_Silent_p.R364R|PPAN_ENST00000253107.7_Silent_p.R417R|PPAN_ENST00000556468.1_Silent_p.R417R	NM_001040664.2|NM_001198690.1	NP_001035754.1|NP_001185619.1	Q9NQ55	SSF1_HUMAN		417					RNA splicing	nucleolus	protein binding			breast(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	31			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			CTCCAGGGCGGAAGCGGAAGC	0.632000													13	97					0	0	1	0	0
PIGV	55650	broad.mit.edu	37	1	27120805	27120805	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr1:27120805G>A	ENST00000374145.1	+	3	962	c.280G>A	c.(280-282)Gcc>Acc	p.A94T	PIGV_ENST00000449950.2_Intron|PIGV_ENST00000078527.4_Missense_Mutation_p.A94T	NM_001202554.1	NP_001189483.1	Q9NUD9	PIGV_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class V	94					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	glycolipid mannosyltransferase activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(2)	14		all_cancers(24;3.93e-26)|all_epithelial(13;3.96e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.26e-54)|Epithelial(14;2.85e-53)|OV - Ovarian serous cystadenocarcinoma(117;1.91e-30)|Colorectal(126;1.31e-09)|COAD - Colon adenocarcinoma(152;3.45e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000504)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.0222)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.153)|LUSC - Lung squamous cell carcinoma(448;0.227)		TTTCCCCTTGGCCCTGCTGGT	0.517000													11	39					0	0	1	0	0
TICAM1	148022	broad.mit.edu	37	19	4817755	4817755	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr19:4817755G>C	ENST00000248244.5	-	2	864	c.635C>G	c.(634-636)tCc>tGc	p.S212C		NM_182919.3	NP_891549.1	Q8IUC6	TCAM1_HUMAN	toll-like receptor adaptor molecule 1	212					apoptosis|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein kinase binding|signal transducer activity			NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	26				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		CATGGTAGGGGACTGGCTGAT	0.662000													25	46					0	0	1	0	0
NCAPD3	23310	broad.mit.edu	37	11	134027937	134027937	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr11:134027937T>C	ENST00000534548.2	-	31	4124	c.4060A>G	c.(4060-4062)Atc>Gtc	p.I1354V		NM_015261.2	NP_056076.1	P42695	CNDD3_HUMAN	non-SMC condensin II complex, subunit D3	1354					cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)		GAATTCAGGATTGCAATGGTG	0.532000													8	194					0	0	1	0	0
ABHD12	26090	broad.mit.edu	37	20	25290154	25290154	+	Missense_Mutation	SNP	T	T	G			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr20:25290154T>G	ENST00000339157.5	-	7	949	c.677A>C	c.(676-678)cAc>cCc	p.H226P	ABHD12_ENST00000481556.1_5'UTR|ABHD12_ENST00000376542.3_Missense_Mutation_p.H226P	NM_001042472.2	NP_001035937.1	Q8N2K0	ABD12_HUMAN	abhydrolase domain containing 12	226						integral to membrane	acylglycerol lipase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|liver(1)|lung(1)|skin(1)|urinary_tract(1)	12						GTCAAAAACGTGGAGTGCGTC	0.597000													8	70					0	0	1	0	0
ZNF705A	440077	broad.mit.edu	37	12	8328510	8328510	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr12:8328510G>C	ENST00000359286.4	+	4	379	c.290G>C	c.(289-291)aGa>aCa	p.R97T		NM_001004328.2|NM_001278713.1	NP_001004328.1|NP_001265642.1	Q6ZN79	Z705A_HUMAN	zinc finger protein 705A	97					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|skin(3)|stomach(4)	18				Kidney(36;0.0877)		CCTATCACCAGAAAAGACGCA	0.343000													19	55					0	0	1	0	0
GPM6B	2824	broad.mit.edu	37	X	13792691	13792691	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chrX:13792691C>T	ENST00000454189.2	-	7	840	c.713G>A	c.(712-714)aGt>aAt	p.S238N	GPM6B_ENST00000356942.5_Missense_Mutation_p.S257N|GPM6B_ENST00000398361.3_Missense_Mutation_p.S171N|GPM6B_ENST00000316715.4_Intron|GPM6B_ENST00000355135.2_Missense_Mutation_p.S297N|GPM6B_ENST00000493677.1_Intron	NM_001001994.1	NP_001001994.1	Q13491	GPM6B_HUMAN	glycoprotein M6B	257					cell differentiation|nervous system development	integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|ovary(1)|pancreas(1)	6						ATCTTCCCGACTCTTAAACTT	0.413000													7	77					0	0	1	0	0
EGFLAM	133584	broad.mit.edu	37	5	38338840	38338840	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr5:38338840A>G	ENST00000322350.5	+	3	594	c.248A>G	c.(247-249)gAg>gGg	p.E83G	EGFLAM_ENST00000354891.3_Missense_Mutation_p.E83G	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	83	Fibronectin type-III 1.					cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					TCCCTGCAGGAGCAGTTGCAC	0.552000													8	26					0	0	1	0	0
CYP27C1	339761	broad.mit.edu	37	2	127951414	127951414	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr2:127951414C>A	ENST00000335247.7	-	6	879	c.749G>T	c.(748-750)cGg>cTg	p.R250L	CYP27C1_ENST00000409327.1_Missense_Mutation_p.R250L	NM_001001665.3	NP_001001665.3	Q4G0S4	C27C1_HUMAN	cytochrome P450, family 27, subfamily C, polypeptide 1	250						membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	p.R250Q(1)		central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|stomach(1)	16	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.071)		CTGGGTGACCCGGCCGTTCCC	0.577000													5	38					0.0215528	0.0216639	1	1	0
MUC17	140453	broad.mit.edu	37	7	100678978	100678978	+	Silent	SNP	G	G	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr7:100678978G>A	ENST00000306151.4	+	3	4345	c.4281G>A	c.(4279-4281)ggG>ggA	p.G1427G		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1427	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GCACCCCTGGGACCACTTCTG	0.493000													59	351					0	0	1	0	0
EMC7	56851	broad.mit.edu	37	15	34393975	34393975	+	Silent	SNP	C	C	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr15:34393975C>T	ENST00000256545.4	-	1	174	c.66G>A	c.(64-66)caG>caA	p.Q22Q	EMC7_ENST00000532113.1_5'UTR	NM_020154.2	NP_064539.1			ER membrane protein complex subunit 7																		CCTCCGAGCTCTGGACATCCC	0.657000													26	160					0	0	1	0	0
NFATC1	4772	broad.mit.edu	37	18	77246388	77246388	+	Missense_Mutation	SNP	G	G	C	rs55839918		TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr18:77246388G>C	ENST00000253506.5	+	9	2602	c.2233G>C	c.(2233-2235)Gtg>Ctg	p.V745L	NFATC1_ENST00000329101.4_Missense_Mutation_p.V732L|NFATC1_ENST00000545796.1_Missense_Mutation_p.V273L|NFATC1_ENST00000542384.1_Intron|NFATC1_ENST00000318065.5_Missense_Mutation_p.V732L|NFATC1_ENST00000586434.1_Intron|NFATC1_ENST00000397790.2_Missense_Mutation_p.V273L|NFATC1_ENST00000427363.2_Missense_Mutation_p.V745L	NM_006162.3	NP_006153.2	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0	Trans-activation domain B (TAD-B).				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(4)|skin(1)|soft_tissue(1)	40		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		CTCCTGCCTCGTGGCCGGCTT	0.657000													23	206					0	0	1	0	0
BCAP29	55973	broad.mit.edu	37	7	107258966	107258966	+	Silent	SNP	G	G	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr7:107258966G>A	ENST00000379119.2	+	8	977	c.963G>A	c.(961-963)ttG>ttA	p.L321L	BCAP29_ENST00000494086.1_3'UTR|BCAP29_ENST00000005259.4_3'UTR|BCAP29_ENST00000445771.2_Silent_p.L321L|BCAP29_ENST00000379117.2_3'UTR|BCAP29_ENST00000465919.1_3'UTR	NM_001008405.2	NP_001008405.1	Q9UHQ4	BAP29_HUMAN	B-cell receptor-associated protein 29	0					apoptosis|intracellular protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|integral to membrane				cervix(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(2)|skin(1)|urinary_tract(1)	14						CAAAATATTTGATGATGTTTC	0.284000													5	14					0	0	1	0	0
VWA3A	146177	broad.mit.edu	37	16	22130322	22130322	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr16:22130322G>A	ENST00000389398.5	+	12	1186	c.1090G>A	c.(1090-1092)Gag>Aag	p.E364K	VWA3A_ENST00000389397.4_5'UTR	NM_173615.3	NP_775886.3	A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	364						extracellular region				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(1)|skin(1)	7				GBM - Glioblastoma multiforme(48;0.0439)		CAGCCCCTGTGAGGCGCTCAC	0.617000													6	19					0	0	1	0	0
ACSS1	84532	broad.mit.edu	37	20	24994690	24994690	+	Silent	SNP	G	G	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr20:24994690G>A	ENST00000537502.1	-	7	2641	c.1110C>T	c.(1108-1110)atC>atT	p.I370I	ACSS1_ENST00000542618.1_Silent_p.I332I|ACSS1_ENST00000323482.4_Silent_p.I453I|ACSS1_ENST00000432802.2_Silent_p.I453I			Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	453					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	26					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	GCCGTGGTGCGATGCAGATGC	0.572000													6	21					0	0	1	0	0
DOCK3	1795	broad.mit.edu	37	3	51367625	51367625	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr3:51367625C>G	ENST00000266037.9	+	33	3482	c.3459C>G	c.(3457-3459)gaC>gaG	p.D1153E		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1153	DHR-2.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		GGAAAGGTGACGAGAGCTACA	0.527000													4	9					0	0	1	0	0
LOXL3	84695	broad.mit.edu	37	2	74776595	74776595	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr2:74776595G>C	ENST00000264094.3	-	4	664	c.593C>G	c.(592-594)tCg>tGg	p.S198W	LOXL3_ENST00000409249.1_Missense_Mutation_p.S198W|LOXL3_ENST00000409986.1_Intron|DOK1_ENST00000409429.1_Intron|LOXL3_ENST00000484369.1_5'UTR|LOXL3_ENST00000409549.1_Missense_Mutation_p.S198W|LOXL3_ENST00000393937.2_Intron	NM_032603.2	NP_115992.1	P58215	LOXL3_HUMAN	lysyl oxidase-like 3	198	SRCR 2.					extracellular space|membrane	copper ion binding|protein-lysine 6-oxidase activity|scavenger receptor activity			endometrium(7)|kidney(2)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	30						GCACACTTGCGACCAGCCGTC	0.652000													20	22					0	0	1	0	0
CATSPERD	257062	broad.mit.edu	37	19	5778493	5778493	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr19:5778493G>A	ENST00000381624.3	+	22	2264	c.2203G>A	c.(2203-2205)Ggg>Agg	p.G735R	CATSPERD_ENST00000309164.7_3'UTR	NM_152784.3	NP_689997.3	Q86XM0	TM146_HUMAN	catsper channel auxiliary subunit delta	735						integral to membrane											CAGCATCCTGGGGTCCGTTTG	0.562000													17	56					0	0	1	0	0
CCDC14	64770	broad.mit.edu	37	3	123634164	123634164	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr3:123634164T>C	ENST00000485727.1	-	9	6316	c.1724A>G	c.(1723-1725)gAt>gGt	p.D575G	CCDC14_ENST00000483247.1_Intron|CCDC14_ENST00000310351.4_Missense_Mutation_p.D615G|CCDC14_ENST00000488653.2_Missense_Mutation_p.D775G|CCDC14_ENST00000433542.2_Missense_Mutation_p.D734G|CCDC14_ENST00000489746.1_Missense_Mutation_p.D575G			Q49A88	CCD14_HUMAN	coiled-coil domain containing 14	775						centrosome				NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)	21		Lung NSC(201;0.0371)|Prostate(884;0.0405)|Myeloproliferative disorder(1037;0.205)		Lung(219;0.00942)|GBM - Glioblastoma multiforme(114;0.159)		AATTGTATTATCCAAATTATG	0.388000													17	72					0	0	1	0	0
TNFSF9	8744	broad.mit.edu	37	19	6534883	6534883	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr19:6534883G>A	ENST00000245817.3	+	3	609	c.571G>A	c.(571-573)Gag>Aag	p.E191K		NM_003811.3	NP_003802.1	P41273	TNFL9_HUMAN	tumor necrosis factor (ligand) superfamily, member 9	191					apoptosis|cell proliferation|cell-cell signaling|immune response|signal transduction	extracellular space|integral to membrane	cytokine activity|tumor necrosis factor receptor binding			central_nervous_system(1)|lung(1)|ovary(1)|prostate(1)|skin(1)	5						CGCCTCCTCCGAGGCTCGGAA	0.692000													7	14					0	0	1	0	0
CHRND	1144	broad.mit.edu	37	2	233390929	233390929	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr2:233390929G>A	ENST00000258385.3	+	1	36	c.4G>A	c.(4-6)Gag>Aag	p.E2K	CHRND_ENST00000536614.1_Missense_Mutation_p.E2K|CHRND_ENST00000543200.1_Missense_Mutation_p.E2K|CHRND_ENST00000457943.2_5'UTR	NM_000751.2	NP_000742.1	Q07001	ACHD_HUMAN	cholinergic receptor, nicotinic, delta (muscle)	2					muscle contraction|musculoskeletal movement|neuromuscular process|skeletal muscle tissue growth|synaptic transmission	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(17)|ovary(3)|prostate(1)|skin(1)|stomach(1)	34		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.89e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00078)|Lung(119;0.00579)|LUSC - Lung squamous cell carcinoma(224;0.00754)		GGATGGGATGGAGGGGCCAGT	0.667000													15	67					0	0	1	0	0
MTTP	4547	broad.mit.edu	37	4	100503108	100503108	+	Silent	SNP	C	C	G			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr4:100503108C>G	ENST00000457717.1	+	3	364	c.108C>G	c.(106-108)ctC>ctG	p.L36L	MTTP_ENST00000265517.5_Silent_p.L36L|MTTP_ENST00000511045.1_Silent_p.L63L|MTTP_ENST00000422897.2_Silent_p.L36L	NM_000253.2	NP_000244.2	P55157	MTP_HUMAN	microsomal triglyceride transfer protein	36	Vitellogenin.				lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity	p.L36L(1)		breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(14)|lung(19)|ovary(4)|prostate(5)|skin(1)|urinary_tract(1)	57				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	TGTACAAGCTCACGTACTCCA	0.458000													14	79					0	0	1	0	0
ZFP69	339559	broad.mit.edu	37	1	40961283	40961283	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr1:40961283C>G	ENST00000372706.1	+	6	2139	c.1133C>G	c.(1132-1134)tCt>tGt	p.S378C	ZFP69_ENST00000372705.3_Missense_Mutation_p.S378C|RP11-656D10.3_ENST00000450713.1_RNA					ZFP69 zinc finger protein																		AGGACTCATTCTGGAGAGAAA	0.398000													7	47					0	0	1	0	0
SARDH	1757	broad.mit.edu	37	9	136597608	136597608	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr9:136597608C>G	ENST00000371872.4	-	3	704	c.447G>C	c.(445-447)caG>caC	p.Q149H	SARDH_ENST00000298628.5_Missense_Mutation_p.Q149H|SARDH_ENST00000371867.1_Missense_Mutation_p.Q60H|SARDH_ENST00000439388.1_Missense_Mutation_p.Q149H|SARDH_ENST00000422262.2_5'UTR	NM_007101.3	NP_009032.2	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase	149					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(13)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	44				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		GGCCCCCATTCTGGATCCAGC	0.672000													71	116					0	0	1	0	0
KCNK15	60598	broad.mit.edu	37	20	43379298	43379298	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr20:43379298G>A	ENST00000372861.3	+	2	943	c.812G>A	c.(811-813)aGc>aAc	p.S271N		NM_022358.3	NP_071753.2	Q9H427	KCNKF_HUMAN	potassium channel, subfamily K, member 15	271						integral to membrane	potassium channel activity|voltage-gated ion channel activity			NS(1)|endometrium(1)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(2)	10		Myeloproliferative disorder(115;0.0122)				gcgcccgAGAGCCGTGGCCTC	0.756000													3	11					0	0	1	0	0
LTBP4	8425	broad.mit.edu	37	19	41113416	41113416	+	Silent	SNP	C	C	G			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr19:41113416C>G	ENST00000308370.7	+	10	1338	c.1338C>G	c.(1336-1338)ctC>ctG	p.L446L	LTBP4_ENST00000396819.3_Silent_p.L379L|LTBP4_ENST00000545697.1_5'UTR|LTBP4_ENST00000204005.9_Silent_p.L409L|LTBP4_ENST00000602240.1_3'UTR	NM_001042544.1	NP_001036009.1	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding protein 4	446	TB 2.				growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GCTGCCAGCTCTGCCCACCCT	0.657000													5	17					0	0	1	0	0
HAL	3034	broad.mit.edu	37	12	96370376	96370376	+	Splice_Site	SNP	C	C	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr12:96370376C>T	ENST00000261208.3	-	19	2131	c.1763G>A	c.(1762-1764)aGg>aAg	p.R588K	HAL_ENST00000538703.1_Splice_Site_p.R588K|HAL_ENST00000541929.1_Splice_Site_p.R380K	NM_002108.3	NP_002099.1	P42357	HUTH_HUMAN	histidine ammonia-lyase	588					biosynthetic process|histidine catabolic process	cytosol	histidine ammonia-lyase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	34					L-Histidine(DB00117)	TTGATCTTACCTTACAACAGA	0.517000													11	59					0	0	1	0	0
ATP13A5	344905	broad.mit.edu	37	3	193031849	193031849	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr3:193031849C>G	ENST00000342358.4	-	19	2409	c.2292G>C	c.(2290-2292)gaG>gaC	p.E764D	ATP13A5-AS1_ENST00000414634.1_RNA	NM_198505.2	NP_940907.2	Q4VNC0	AT135_HUMAN	ATPase type 13A5	764					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(1)|autonomic_ganglia(2)|breast(1)|endometrium(6)|kidney(4)|large_intestine(15)|liver(2)|lung(26)|ovary(5)|prostate(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		TCTCTTGGTTCTCCACCAGCT	0.517000													16	98					0	0	1	0	0
GRK5	2869	broad.mit.edu	37	10	121207652	121207652	+	Silent	SNP	G	G	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr10:121207652G>A	ENST00000392870.2	+	13	1613	c.1284G>A	c.(1282-1284)gcG>gcA	p.A428A	GRK5_ENST00000369108.3_Silent_p.A323A	NM_005308.2	NP_005299.1	P34947	GRK5_HUMAN	G protein-coupled receptor kinase 5	428	Protein kinase.				G-protein signaling, coupled to cAMP nucleotide second messenger|regulation of G-protein coupled receptor protein signaling pathway|tachykinin receptor signaling pathway	cytoplasm|plasma membrane|soluble fraction	ATP binding|G-protein coupled receptor kinase activity|phospholipid binding|protein kinase C binding|signal transducer activity			endometrium(2)|large_intestine(5)|lung(15)|skin(3)|stomach(1)|urinary_tract(1)	27		Lung NSC(174;0.0971)|all_lung(145;0.127)|Ovarian(717;0.249)		all cancers(201;0.0227)		CGAAAGATGCGAAGCAGAGGC	0.597000													18	108					0	0	1	0	0
MID1	4281	broad.mit.edu	37	X	10534939	10534939	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chrX:10534939C>T	ENST00000317552.4	-	2	1049	c.649G>A	c.(649-651)Gac>Aac	p.D217N	MID1_ENST00000380779.1_Missense_Mutation_p.D217N|MID1_ENST00000380780.1_Missense_Mutation_p.D217N|MID1_ENST00000380782.2_Missense_Mutation_p.D217N|MID1_ENST00000453318.2_Missense_Mutation_p.D217N|MID1_ENST00000380785.1_Missense_Mutation_p.D217N|MID1_ENST00000380787.1_Missense_Mutation_p.D217N	NM_000381.3|NM_033289.1	NP_000372.1|NP_150631.1	O15344	TRI18_HUMAN	midline 1 (Opitz/BBB syndrome)	217					microtubule cytoskeleton organization|pattern specification process|positive regulation of stress-activated MAPK cascade	cytoplasm|microtubule|microtubule associated complex|spindle	ligase activity|ubiquitin protein ligase binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	26						TTCAATTTGTCATAGCGCTCA	0.473000													10	48					0	0	1	0	0
POTEH	23784	broad.mit.edu	37	22	16266988	16266988	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr22:16266988C>A	ENST00000343518.6	-	9	1512	c.1461G>T	c.(1459-1461)agG>agT	p.R487S		NM_001136213.1	NP_001129685.1	Q6S545	POTEH_HUMAN	POTE ankyrin domain family, member H	487										NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(20)|ovary(1)|skin(7)|urinary_tract(2)	37						TTCTGCTTTTCCTTGGTGGAA	0.433000													8	289					1.49906e-05	1.58009e-05	1	1	0
SOX12	6666	broad.mit.edu	37	20	307492	307492	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr20:307492C>G	ENST00000342665.2	+	1	1254	c.924C>G	c.(922-924)atC>atG	p.I308M	SOX12_ENST00000544632.1_Missense_Mutation_p.I308M|RP5-1103G7.4_ENST00000442637.1_RNA	NM_006943.2	NP_008874.2	O15370	SOX12_HUMAN	SRY (sex determining region Y)-box 12	308					cell fate commitment|spinal cord development	nucleus	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription coactivator activity|transcription regulatory region sequence-specific DNA binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)	2		all_cancers(10;0.000331)|Lung NSC(37;0.0496)|all_lung(30;0.0831)|all_epithelial(17;0.0868)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.149)			CGTCTAGCATCGCAGACCTGG	0.637000													16	79					0	0	1	0	0
ZNF423	23090	broad.mit.edu	37	16	49672522	49672522	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr16:49672522G>A	ENST00000561648.1	-	4	594	c.541C>T	c.(541-543)Cgt>Tgt	p.R181C	ZNF423_ENST00000567169.1_Missense_Mutation_p.R64C|ZNF423_ENST00000535559.1_Missense_Mutation_p.R64C|ZNF423_ENST00000262383.2_Missense_Mutation_p.R181C|ZNF423_ENST00000562871.1_Missense_Mutation_p.R121C|ZNF423_ENST00000562520.1_Missense_Mutation_p.R121C|ZNF423_ENST00000563137.2_Missense_Mutation_p.R121C	NM_001271620.1	NP_001258549.1	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	181					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				TGCCGGTCACGGCTCCTCTTG	0.582000													23	24					0	0	1	0	0
TMPRSS11A	339967	broad.mit.edu	37	4	68810291	68810291	+	Silent	SNP	G	G	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr4:68810291G>A	ENST00000508048.1	-	3	230	c.195C>T	c.(193-195)ttC>ttT	p.F65F	TMPRSS11A_ENST00000334830.7_Silent_p.F66F|TMPRSS11A_ENST00000396188.2_Silent_p.F66F|UBA6-AS1_ENST00000500538.2_RNA			Q6ZMR5	TM11A_HUMAN	transmembrane protease, serine 11A	66	SEA.				cell cycle|proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			breast(1)|cervix(2)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	29						TGCTTTGTCCGAAATTGTTAT	0.333000													27	54					0	0	1	0	0
RAD51C	5889	broad.mit.edu	37	17	56770065	56770065	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr17:56770065C>A	ENST00000337432.4	+	1	132	c.61C>A	c.(61-63)Cca>Aca	p.P21T	RAD51C_ENST00000487921.1_Intron|RAD51C_ENST00000421782.2_Missense_Mutation_p.P21T|RAD51C_ENST00000583539.1_Missense_Mutation_p.P21T	NM_058216.1	NP_478123.1	O43502	RA51C_HUMAN	RAD51 paralog C	21					blood coagulation|DNA repair	mitochondrion|nucleoplasm|perinuclear region of cytoplasm	ATP binding|DNA binding|DNA-dependent ATPase activity			upper_aerodigestive_tract(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CCCGCTGTCTCCAGCGGTGCG	0.592000								Homologous recombination	Hereditary Breast-Ovarian Cancer, non-BRCA1/2				39	100					2.2871e-25	2.65466e-25	1	1	0
KIAA1109	84162	broad.mit.edu	37	4	123249453	123249453	+	Silent	SNP	G	G	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr4:123249453G>A	ENST00000264501.4	+	66	11563	c.11190G>A	c.(11188-11190)gaG>gaA	p.E3730E	KIAA1109_ENST00000388738.3_Silent_p.E3730E			Q2LD37	K1109_HUMAN	KIAA1109	3730					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						AAGATTCCGAGAAGGATGAAA	0.418000													11	41					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26500796	26500796	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr10:26500796G>C	ENST00000265944.5	+	35	4921	c.4755G>C	c.(4753-4755)gaG>gaC	p.E1585D	MYO3A_ENST00000543632.1_Missense_Mutation_p.E601Q	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1585					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						AGAGCCCCGAGAAGGAGGAGG	0.652000													7	57					0	0	1	0	0
PCDH10	57575	broad.mit.edu	37	4	134071764	134071764	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr4:134071764C>T	ENST00000264360.5	+	1	1295	c.469C>T	c.(469-471)Cgc>Tgc	p.R157C		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10		Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		CAACTCCTTGCGCGACTACGA	0.622000													10	89					0	0	1	0	0
MAGI3	260425	broad.mit.edu	37	1	114162391	114162391	+	Silent	SNP	A	A	C			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr1:114162391A>C	ENST00000369615.1	+	8	1172	c.1110A>C	c.(1108-1110)ccA>ccC	p.P370P	MAGI3_ENST00000369617.4_Silent_p.P395P|MAGI3_ENST00000369611.4_Silent_p.P370P|MAGI3_ENST00000307546.9_Silent_p.P370P	NM_152900.2	NP_690864.2	Q5TCQ9	MAGI3_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 3	395	WW 2.				apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(9)|ovary(3)|prostate(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	41	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTGAAAATCCAGTGGAGGAAG	0.323000													14	47					0	0	1	0	0
GPX1	2876	broad.mit.edu	37	3	49394933	49394933	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr3:49394933A>G	ENST00000419783.1	-	2	821	c.500T>C	c.(499-501)tTc>tCc	p.F167S	GPX1_ENST00000419349.1_3'UTR	NM_000581.2	NP_000572.2	P07203	GPX1_HUMAN	glutathione peroxidase 1	167					anti-apoptosis|cell redox homeostasis|glutathione metabolic process|heart contraction|hydrogen peroxide catabolic process|negative regulation of caspase activity|purine base metabolic process|purine nucleotide catabolic process|regulation of gene expression, epigenetic|regulation of mammary gland epithelial cell proliferation|regulation of proteasomal protein catabolic process|release of cytochrome c from mitochondria|response to selenium ion|UV protection	cytosol|mitochondrion	endopeptidase inhibitor activity|glutathione peroxidase activity|SH3 domain binding			breast(1)|large_intestine(2)|lung(1)	4				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Glutathione(DB00143)	GCCCACCAGGAACTTCTCAAA	0.622000													8	68					0	0	1	0	0
OTOP2	92736	broad.mit.edu	37	17	72926794	72926794	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr17:72926794G>A	ENST00000331427.4	+	6	1156	c.1064G>A	c.(1063-1065)cGg>cAg	p.R355Q	OTOP2_ENST00000580223.1_Missense_Mutation_p.R355Q	NM_178160.2	NP_835454.1	Q7RTS6	OTOP2_HUMAN	otopetrin 2	355						integral to membrane				breast(4)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(13)|ovary(3)|prostate(4)|skin(1)|urinary_tract(2)	39	all_lung(278;0.172)|Lung NSC(278;0.207)					TTTGACCGCCGGGCCATGGAC	0.592000													9	99					0	0	1	0	0
PLA2G3	50487	broad.mit.edu	37	22	31536233	31536233	+	Silent	SNP	G	G	A	rs2232175	byFrequency	TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr22:31536233G>A	ENST00000215885.3	-	1	360	c.108C>T	c.(106-108)gcC>gcT	p.A36A		NM_015715.3	NP_056530.2	Q9NZ20	PA2G3_HUMAN	phospholipase A2, group III	36					cilium morphogenesis|lipid catabolic process|phospholipid metabolic process	centriole|extracellular space|plasma membrane	calcium ion binding|calcium-dependent phospholipase A2 activity			large_intestine(1)|lung(10)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	18						TGCCAGGGACGGCCTTGGTCA	0.662000													11	83					0	0	1	0	0
CDH16	1014	broad.mit.edu	37	16	66949261	66949261	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr16:66949261C>G	ENST00000299752.4	-	6	638	c.445G>C	c.(445-447)Gag>Cag	p.E149Q	CDH16_ENST00000565796.1_Missense_Mutation_p.E149Q|CDH16_ENST00000394055.3_Missense_Mutation_p.E149Q|CDH16_ENST00000568632.1_Intron|CDH16_ENST00000570262.1_Missense_Mutation_p.E69Q	NM_001204744.1|NM_001204745.1|NM_004062.3	NP_001191673.1|NP_001191674.1|NP_004053.1	O75309	CAD16_HUMAN	cadherin 16, KSP-cadherin	149	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(1)|kidney(3)|large_intestine(10)|lung(15)|ovary(2)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		TCTGAAGCCTCAAGGAAGAGG	0.582000													32	41					0	0	1	0	0
RNF123	63891	broad.mit.edu	37	3	49736208	49736208	+	Silent	SNP	C	C	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr3:49736208C>T	ENST00000327697.6	+	9	735	c.591C>T	c.(589-591)atC>atT	p.I197I	RNF123_ENST00000432042.1_Silent_p.I51I	NM_022064.3	NP_071347.2	Q5XPI4	RN123_HUMAN	ring finger protein 123	197	B30.2/SPRY.					cytoplasm	ligase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		CGGGGGACATCGTGAGCTGCC	0.612000													19	34					0	0	1	0	0
LOC643923	643923	broad.mit.edu	37	11	107463146	107463146	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr11:107463146C>T	ENST00000600612.1	+	2	357	c.344C>T	c.(343-345)tCt>tTt	p.S115F	ELMOD1_ENST00000443271.2_Intron|ELMOD1_ENST00000529675.1_3'UTR|ELMOD1_ENST00000265840.7_Intron|ELMOD1_ENST00000531234.1_Intron																							AGGCATTGTTCTGCATCTCTG	0.483000													15	31					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195516420	195516420	+	Silent	SNP	C	C	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr3:195516420C>T	ENST00000463781.3	-	2	2490	c.2031G>A	c.(2029-2031)tcG>tcA	p.S677S	MUC4_ENST00000349607.4_Intron|MUC4_ENST00000346145.4_Intron|MUC4_ENST00000475231.1_Silent_p.S677S	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	682					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TTTCTGAGGGCGAGTGCCCAC	0.582000													31	88					0	0	1	0	0
BMP2K	55589	broad.mit.edu	37	4	79832928	79832928	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr4:79832928C>T	ENST00000335016.5	+	16	3393	c.3227C>T	c.(3226-3228)tCt>tTt	p.S1076F	PAQR3_ENST00000295462.3_Intron	NM_198892.1	NP_942595.1	Q9NSY1	BMP2K_HUMAN	BMP2 inducible kinase	1076						nucleus	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|endometrium(4)|large_intestine(2)|lung(3)|prostate(1)|urinary_tract(1)	13						CCCTTCCATTCTCCAGACCTG	0.532000													35	71					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33413826	33413826	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr2:33413826A>G	ENST00000404816.2	+	7	1962	c.1609A>G	c.(1609-1611)Aca>Gca	p.T537A	LTBP1_ENST00000402934.1_Missense_Mutation_p.T211A|LTBP1_ENST00000390003.4_Missense_Mutation_p.T211A|LTBP1_ENST00000404525.1_Missense_Mutation_p.T211A|LTBP1_ENST00000354476.3_Missense_Mutation_p.T537A|LTBP1_ENST00000418533.2_Missense_Mutation_p.T211A|LTBP1_ENST00000407925.1_Missense_Mutation_p.T211A			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	537					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				CATACATTCCACATACTCCCA	0.537000													16	165					0	0	1	0	0
CAMTA1	23261	broad.mit.edu	37	1	7798176	7798176	+	Silent	SNP	C	C	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr1:7798176C>T	ENST00000303635.7	+	16	4023	c.3816C>T	c.(3814-3816)atC>atT	p.I1272I	CAMTA1_ENST00000439411.2_Silent_p.I1272I	NM_015215.2	NP_056030.1	Q9Y6Y1	CMTA1_HUMAN	calmodulin binding transcription activator 1	1272					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(11)|lung(29)|ovary(5)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	85	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		AGCCAAATATCAGGAAGCAAA	0.532000			T	WWTR1	epitheliod hemangioendothelioma								13	49					0	0	1	0	0
CDT1	81620	broad.mit.edu	37	16	88872213	88872213	+	Silent	SNP	C	C	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr16:88872213C>A	ENST00000301019.4	+	5	1387	c.768C>A	c.(766-768)ccC>ccA	p.P256P		NM_030928.3	NP_112190.2	Q9H211	CDT1_HUMAN	chromatin licensing and DNA replication factor 1	256					DNA replication|DNA replication checkpoint|M/G1 transition of mitotic cell cycle|regulation of DNA-dependent DNA replication initiation|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nucleoplasm	DNA binding|protein binding			central_nervous_system(1)|endometrium(2)|kidney(1)|lung(3)	7				BRCA - Breast invasive adenocarcinoma(80;0.0476)		GCAGTGTCCCCACCTTCAAGG	0.612000													3	23					6.4e-05	6.60317e-05	1	1	0
RET	5979	broad.mit.edu	37	10	43600508	43600508	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr10:43600508T>C	ENST00000355710.3	+	4	966	c.734T>C	c.(733-735)gTg>gCg	p.V245A	RET_ENST00000340058.5_Missense_Mutation_p.V245A	NM_020975.4	NP_066124.1	P07949	RET_HUMAN	ret proto-oncogene	245	Cadherin.				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity		CCDC6/RET(4)|KIF5B/RET(79)	NS(2)|adrenal_gland(26)|breast(5)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|lung(27)|ovary(5)|prostate(3)|skin(1)|thyroid(504)|upper_aerodigestive_tract(1)|urinary_tract(1)	607		Ovarian(717;0.0423)			Sunitinib(DB01268)	GTGTGCACCGTGCACGCCGGC	0.731000		1	"""T, Mis, N, F"""	"""H4, PRKAR1A, NCOA4, PCM1, GOLGA5, TRIM33, KTN1, TRIM27, HOOK3, KIF5B, CCDC6"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma, NSCLC"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma"""	Hirschsprung disease		Multiple Endocrine Neoplasia, type 2B;Multiple Endocrine Neoplasia, type 2A;Familial Medullary Thyroid Carcinoma				4	34					0	0	1	0	0
CREG1	8804	broad.mit.edu	37	1	167517352	167517352	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr1:167517352G>A	ENST00000370509.4	-	2	386	c.361C>T	c.(361-363)Cca>Tca	p.P121S		NM_003851.2	NP_003842.1	O75629	CREG1_HUMAN	cellular repressor of E1A-stimulated genes 1	121					cell proliferation|multicellular organismal development|regulation of growth|regulation of transcription from RNA polymerase II promoter	extracellular region	FMN binding|transcription corepressor activity										GTAGCATATGGATTCTCCTAT	0.398000													9	46					0	0	1	0	0
C20orf166-AS1	253868	broad.mit.edu	37	20	61143549	61143549	+	RNA	SNP	C	C	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr20:61143549C>T	ENST00000475015.1	-	0	789				C20orf166-AS1_ENST00000412495.1_RNA																							GTGCCACATTCTGAGCACAGA	0.642000													19	78					0	0	1	0	0
IRF9	10379	broad.mit.edu	37	14	24620550	24620550	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr14:24620550G>A	ENST00000558468.1	+	1	124	c.124G>A	c.(124-126)Gaa>Aaa	p.E42K	RNF31_ENST00000559275.1_Missense_Mutation_p.E416K|RNF31_ENST00000324103.6_Missense_Mutation_p.E567K|RNF31_ENST00000382687.3_Missense_Mutation_p.E416K																							CAACCTTGATGAAGCTGTGGA	0.592000													19	44					0	0	1	0	0
HIST1H2AE	3012	broad.mit.edu	37	6	26217258	26217258	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr6:26217258C>T	ENST00000303910.2	+	1	94	c.56C>T	c.(55-57)tCt>tTt	p.S19F		NM_021052.2	NP_066390.1	P04908	H2A1B_HUMAN	histone cluster 1, H2ae	19					nucleosome assembly	nucleosome|nucleus	DNA binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(3)|ovary(1)|skin(2)	10		all_hematologic(11;0.196)				AAAACGCGTTCTTCCAGGGCC	0.557000													20	34					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168102949	168102949	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr2:168102949G>A	ENST00000409195.1	+	9	5136	c.5047G>A	c.(5047-5049)Gaa>Aaa	p.E1683K	XIRP2_ENST00000409273.1_Missense_Mutation_p.E1461K|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.E1683K|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409728.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1508					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						TCAGGAAGATGAAAAAGGAGA	0.348000													7	32					0	0	1	0	0
PCDHA12	56137	broad.mit.edu	37	5	140255136	140255136	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr5:140255136G>T	ENST00000398631.2	+	1	79	c.79G>T	c.(79-81)Ggg>Tgg	p.G27W	PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron	NM_018903.2|NM_031864.2	NP_061726.1|NP_114070.1														NS(4)|breast(2)|cervix(1)|endometrium(19)|kidney(8)|large_intestine(8)|liver(2)|lung(25)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGGGAGGTGGGGAGCGGCCA	0.637000													12	50					2.80697e-09	3.07506e-09	1	1	0
IKZF1	10320	broad.mit.edu	37	7	50468250	50468250	+	Silent	SNP	C	C	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr7:50468250C>T	ENST00000331340.3	+	8	1640	c.1485C>T	c.(1483-1485)tgC>tgT	p.C495C	IKZF1_ENST00000343574.5_Silent_p.C408C|IKZF1_ENST00000359197.5_Silent_p.C453C|IKZF1_ENST00000438033.1_Silent_p.C408C|IKZF1_ENST00000357364.4_Silent_p.C408C|IKZF1_ENST00000349824.4_Silent_p.C352C|IKZF1_ENST00000346667.4_Silent_p.C265C|IKZF1_ENST00000439701.1_Silent_p.C453C|IKZF1_ENST00000440768.2_3'UTR	NM_001220769.1|NM_001220772.1|NM_001220773.1|NM_001220775.1|NM_006060.4	NP_001207698.1|NP_001207701.1|NP_001207702.1|NP_001207704.1|NP_006051.1	Q13422	IKZF1_HUMAN	IKAROS family zinc finger 1 (Ikaros)	495					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(28)		haematopoietic_and_lymphoid_tissue(275)|lung(1)	276	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				GCAACATGTGCGGCTACCACA	0.602000			"""D,T"""	BCL6	"""ALL, DLBCL"""								10	28					0	0	1	0	0
ZBTB40	9923	broad.mit.edu	37	1	22839532	22839532	+	Silent	SNP	C	C	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr1:22839532C>T	ENST00000404138.1	+	13	3088	c.2577C>T	c.(2575-2577)acC>acT	p.T859T	ZBTB40_ENST00000375647.4_Silent_p.T859T|ZBTB40_ENST00000374651.4_Silent_p.T747T	NM_001083621.1	NP_001077090.1	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	859					bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(4)|large_intestine(6)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		GCCTTCACACCGGGGACCGCC	0.572000													4	46					0	0	1	0	0
STXBP5L	9515	broad.mit.edu	37	3	120976150	120976150	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr3:120976150G>C	ENST00000273666.6	+	17	2073	c.1802G>C	c.(1801-1803)gGa>gCa	p.G601A	STXBP5L_ENST00000492541.1_Missense_Mutation_p.G601A|STXBP5L_ENST00000472879.1_Missense_Mutation_p.G601A|STXBP5L_ENST00000497029.1_Missense_Mutation_p.G601A|STXBP5L_ENST00000471454.1_Missense_Mutation_p.G601A	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	601					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		GCTAGTGAAGGAGTAACAAAG	0.403000													3	64					0	0	1	0	0
ZNF318	24149	broad.mit.edu	37	6	43305512	43305512	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr6:43305512G>A	ENST00000361428.2	-	10	6301	c.6224C>T	c.(6223-6225)tCt>tTt	p.S2075F	ZNF318_ENST00000318149.3_Intron	NM_014345.2	NP_055160.2	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	2075					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(21)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	61			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			GGTTTTGGGAGAATCTAACGG	0.438000													17	43					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179463357	179463357	+	Missense_Mutation	SNP	T	T	G			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr2:179463357T>G	ENST00000589042.1	-	292	57211	c.56987A>C	c.(56986-56988)aAa>aCa	p.K18996T	TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.K10056T|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.K17355T|TTN_ENST00000460472.2_Missense_Mutation_p.K9931T|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.K10123T|TTN-AS1_ENST00000589234.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.K16428T|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000586452.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	17355	Fibronectin type-III 37.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCTGTCACTTTGGGAAATGG	0.403000													7	20					0	0	1	0	0
DLG4	1742	broad.mit.edu	37	17	7099849	7099849	+	Missense_Mutation	SNP	T	T	G			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr17:7099849T>G	ENST00000399510.2	-	12	2110	c.1258A>C	c.(1258-1260)Att>Ctt	p.I420L	DLG4_ENST00000399506.2_Missense_Mutation_p.I377L|DLG4_ENST00000302955.6_Missense_Mutation_p.I374L	NM_001365.3	NP_001356.1	P78352	DLG4_HUMAN	discs, large homolog 4 (Drosophila)	377					axon guidance|learning|protein complex assembly|protein localization to synapse|signal transduction|synaptic transmission	cell junction|cortical cytoskeleton|endocytic vesicle membrane|neuron spine|postsynaptic density|postsynaptic membrane|synaptosome	protein binding|protein C-terminus binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)	18						TTCAGGGCAATGGCAGCCTGC	0.562000													7	55					0	0	1	0	0
KRT83	3889	broad.mit.edu	37	12	52715044	52715044	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr12:52715044G>A	ENST00000293670.3	-	1	138	c.76C>T	c.(76-78)Cgg>Tgg	p.R26W		NM_002282.3	NP_002273.3	P78385	KRT83_HUMAN	keratin 83	26	Head.				epidermis development	keratin filament	structural molecule activity			NS(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(9)|prostate(1)|skin(4)|stomach(7)|upper_aerodigestive_tract(1)	32	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		CGGCTTGGCCGGGGCCCGCAG	0.662000													43	95					0	0	1	0	0
BACE1	23621	broad.mit.edu	37	11	117165945	117165945	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr11:117165945G>A	ENST00000313005.6	-	3	929	c.469C>T	c.(469-471)Cgt>Tgt	p.R157C	BACE1_ENST00000513780.1_Missense_Mutation_p.R157C|BACE1_ENST00000428381.2_Intron|BACE1_ENST00000510630.1_Missense_Mutation_p.R57C|BACE1_ENST00000528053.1_Missense_Mutation_p.R157C|BACE1_ENST00000514464.1_Intron|BACE1_ENST00000445823.2_Intron|BACE1_ENST00000392937.6_Missense_Mutation_p.R57C	NM_012104.4|NM_138971.3|NM_138972.3|NM_138973.3	NP_036236|NP_620427.1|NP_620428.1|NP_620429.1	P56817	BACE1_HUMAN	beta-site APP-cleaving enzyme 1	157					beta-amyloid metabolic process|membrane protein ectodomain proteolysis	cell surface|cytoplasmic vesicle membrane|endoplasmic reticulum|endosome|integral to plasma membrane|trans-Golgi network	aspartic-type endopeptidase activity|beta-aspartyl-peptidase activity|protein binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|prostate(1)	19	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.69e-05)|Epithelial(105;0.000563)|all cancers(92;0.0032)		ATGTTGGCACGCACAGTGACG	0.592000													4	107					0	0	1	0	0
DLAT	1737	broad.mit.edu	37	11	111896264	111896264	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr11:111896264C>A	ENST00000280346.6	+	1	727	c.68C>A	c.(67-69)aCg>aAg	p.T23K	DLAT_ENST00000393051.1_Missense_Mutation_p.T23K	NM_001931.4	NP_001922.2	P10515	ODP2_HUMAN	dihydrolipoamide S-acetyltransferase	23					glycolysis|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial pyruvate dehydrogenase complex	dihydrolipoyllysine-residue acetyltransferase activity|protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(10)|ovary(1)|skin(1)	22		all_cancers(61;4.53e-11)|all_epithelial(67;2.76e-06)|Melanoma(852;9.42e-06)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0512)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)		Epithelial(105;4.87e-07)|BRCA - Breast invasive adenocarcinoma(274;6.83e-07)|all cancers(92;9.63e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0557)	NADH(DB00157)	GCTCGGTGGACGGCCTTGCAG	0.667000													12	50					9.31168e-06	9.86836e-06	1	1	0
IL3RA	3563	broad.mit.edu	37	X	1499970	1499970	+	Silent	SNP	C	C	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chrX:1499970C>A	ENST00000331035.4	+	11	1384	c.1035C>A	c.(1033-1035)atC>atA	p.I345I	IL3RA_ENST00000381469.2_Silent_p.I267I	NM_001267713.1|NM_002183.3	NP_001254642.1|NP_002174.1	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha (low affinity)	345						integral to membrane|plasma membrane	interleukin-3 receptor activity			lung(1)|skin(2)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	AAGACCCCATCGGTGACAGCT	0.567000													34	201					1.22384e-17	1.3956e-17	1	1	0
USP54	159195	broad.mit.edu	37	10	75283447	75283447	+	Silent	SNP	C	C	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr10:75283447C>T	ENST00000339859.4	-	16	2356	c.2256G>A	c.(2254-2256)gcG>gcA	p.A752A	USP54_ENST00000394811.2_5'UTR|USP54_ENST00000428547.1_Silent_p.A602A|USP54_ENST00000408019.1_Silent_p.A752A|USP54_ENST00000497106.1_5'UTR			Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	752					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(5)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)	30	Prostate(51;0.0112)					CCTGTTCCTGCGCCCTCCTGG	0.478000													50	123					0	0	1	0	0
PHKA2	5256	broad.mit.edu	37	X	18923972	18923972	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chrX:18923972C>G	ENST00000379942.4	-	26	3477	c.2812G>C	c.(2812-2814)Gag>Cag	p.E938Q		NM_000292.2	NP_000283.1	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	938					glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			NS(1)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(12)|lung(23)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	61	Hepatocellular(33;0.183)					TCAGAAGCCTCTTCTCCTAAA	0.468000													12	67					0	0	1	0	0
HGF	3082	broad.mit.edu	37	7	81335683	81335683	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr7:81335683C>G	ENST00000222390.5	-	15	1903	c.1677G>C	c.(1675-1677)gaG>gaC	p.E559D	HGF_ENST00000457544.2_Missense_Mutation_p.E554D	NM_000601.4	NP_000592.3	P14210	HGF_HUMAN	hepatocyte growth factor (hepapoietin A; scatter factor)	559	Peptidase S1.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(41)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	75						GTTTGCATTTCTCATCTCCTC	0.363000													26	75					0	0	1	0	0
CTC-435M10.3	0	broad.mit.edu	37	19	41884266	41884266	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr19:41884266G>A	ENST00000540732.1	+	2	179	c.52G>A	c.(52-54)Gaa>Aaa	p.E18K	TMEM91_ENST00000544232.1_Missense_Mutation_p.E18K|TMEM91_ENST00000436170.2_Missense_Mutation_p.E18K|TMEM91_ENST00000413014.2_Missense_Mutation_p.E18K|TMEM91_ENST00000542945.1_Missense_Mutation_p.E18K|TMEM91_ENST00000447302.2_Missense_Mutation_p.E18K|TMEM91_ENST00000539627.1_Missense_Mutation_p.E18K|CTC-435M10.3_ENST00000604424.1_Intron|TMEM91_ENST00000604123.1_Missense_Mutation_p.E75K|TMEM91_ENST00000356385.4_Missense_Mutation_p.E18K|BCKDHA_ENST00000595085.1_Missense_Mutation_p.E18K|TMEM91_ENST00000392002.2_Missense_Mutation_p.E18K																							GGAGGGCACAGAATGTGAGAC	0.582000													75	69					0	0	1	0	0
MYOT	9499	broad.mit.edu	37	5	137211532	137211532	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr5:137211532C>T	ENST00000239926.4	+	3	745	c.371C>T	c.(370-372)tCa>tTa	p.S124L	MYOT_ENST00000421631.2_5'UTR|MYOT_ENST00000515645.1_Missense_Mutation_p.S9L|RP11-381K20.2_ENST00000514616.1_RNA|MYOT_ENST00000509812.1_3'UTR	NM_006790.2	NP_006781	Q9UBF9	MYOTI_HUMAN	myotilin	124	Necessary for interaction with ACTN1.				muscle contraction	actin cytoskeleton|sarcolemma|sarcomere	actin binding|structural constituent of muscle			cervix(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(1)|prostate(1)|urinary_tract(1)	23			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			CAACAGTCCTCAGCTGGCCAA	0.368000													10	45					0	0	1	0	0
MED12L	116931	broad.mit.edu	37	3	151090536	151090536	+	Silent	SNP	G	G	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr3:151090536G>A	ENST00000474524.1	+	25	3779	c.3741G>A	c.(3739-3741)ctG>ctA	p.L1247L	P2RY12_ENST00000302632.3_Intron|MED12L_ENST00000273432.4_Silent_p.L1107L	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	1247					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GATATGTACTGAGGACTATCT	0.363000													21	45					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92616249	92616249	+	Silent	SNP	C	C	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr11:92616249C>T	ENST00000298047.6	+	23	12644	c.12627C>T	c.(12625-12627)ttC>ttT	p.F4209F	FAT3_ENST00000409404.2_Silent_p.F4209F|FAT3_ENST00000525166.1_Silent_p.F4059F|FAT3_ENST00000533797.1_Silent_p.F544F			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	4209					homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GCATCCCGTTCCGGAACCTGC	0.652000										TCGA Ovarian(4;0.039)			32	96					0	0	1	0	0
TTK	7272	broad.mit.edu	37	6	80732049	80732049	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr6:80732049G>C	ENST00000509894.1	+	11	1946	c.1117G>C	c.(1117-1119)Gag>Cag	p.E373Q	TTK_ENST00000369798.2_Missense_Mutation_p.E373Q|TTK_ENST00000515751.1_3'UTR|TTK_ENST00000230510.3_Missense_Mutation_p.E373Q			P33981	TTK_HUMAN	TTK protein kinase	373					mitotic cell cycle spindle assembly checkpoint|mitotic spindle organization|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation	spindle	ATP binding|identical protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(4)|kidney(2)|large_intestine(12)|lung(22)|ovary(7)|pancreas(1)|prostate(1)|stomach(3)|urinary_tract(1)	53		all_cancers(76;0.00177)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.2)		BRCA - Breast invasive adenocarcinoma(397;0.0321)		AGAAACTAAAGAGTATCAAGA	0.328000													24	45					0	0	1	0	0
PTPRG	5793	broad.mit.edu	37	3	62153735	62153735	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr3:62153735C>T	ENST00000474889.1	+	8	1308	c.931C>T	c.(931-933)Cgt>Tgt	p.R311C	PTPRG_ENST00000295874.10_Missense_Mutation_p.R311C	NM_002841.3	NP_002832.3	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	311	Alpha-carbonic anhydrase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|liver(2)|lung(15)|ovary(7)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	62				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		ACCACAGCAGCGTCTGCATGA	0.512000													11	65					0	0	1	0	0
NDUFS8	4728	broad.mit.edu	37	11	67803985	67803985	+	Silent	SNP	G	G	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr11:67803985G>A	ENST00000313468.5	+	7	665	c.558G>A	c.(556-558)gaG>gaA	p.E186E	NDUFS8_ENST00000528492.1_Silent_p.E40E	NM_002496.3	NP_002487.1	O00217	NDUS8_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)	186					mitochondrial electron transport, NADH to ubiquinone|mitochondrial respiratory chain complex I assembly|response to oxidative stress|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|NADH dehydrogenase (ubiquinone) activity			endometrium(1)|kidney(1)|lung(5)|skin(1)	8					NADH(DB00157)	ACAACAAGGAGAAGTTGCTCA	0.617000													7	34					0	0	1	0	0
AVIL	10677	broad.mit.edu	37	12	58197374	58197374	+	Missense_Mutation	SNP	C	C	T	rs143313987		TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr12:58197374C>T	ENST00000537081.1	-	14	1728	c.1729G>A	c.(1729-1731)Gag>Aag	p.E577K	AVIL_ENST00000550083.1_Intron|TSFM_ENST00000548851.1_Intron|AVIL_ENST00000257861.3_Missense_Mutation_p.E584K			O75366	AVIL_HUMAN	advillin	584	Core (By similarity).				actin filament capping|cilium morphogenesis|cytoskeleton organization|positive regulation of neuron projection development	actin cytoskeleton|axon|cytoplasm	actin binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(9)|ovary(1)|prostate(6)	32	Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)					TCCTGGCCCTCGGCCACAGTG	0.602000											OREG0021955	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	29					0	0	1	0	0
ZNF813	126017	broad.mit.edu	37	19	53994668	53994668	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr19:53994668G>T	ENST00000396403.4	+	4	1310	c.1182G>T	c.(1180-1182)caG>caT	p.Q394H	ZNF813_ENST00000396421.4_Intron	NM_001004301.3	NP_001004301.2	Q6ZN06	ZN813_HUMAN	zinc finger protein 813	394					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.Q394Q(1)		large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)		CCTTCAGTCAGGAGTTAACCC	0.418000													14	135					1.05317e-09	1.16686e-09	1	1	0
KDR	3791	broad.mit.edu	37	4	55987280	55987280	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr4:55987280G>C	ENST00000263923.4	-	2	440	c.145C>G	c.(145-147)Ctt>Gtt	p.L49V		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	49	Ig-like C2-type 1.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	GTAATTTGAAGAGTTGTATTA	0.328000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			13	25					0	0	1	0	0
HECW2	57520	broad.mit.edu	37	2	197118738	197118738	+	Silent	SNP	C	C	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr2:197118738C>T	ENST00000260983.3	-	19	3617	c.3435G>A	c.(3433-3435)gaG>gaA	p.E1145E	HECW2_ENST00000409111.1_Silent_p.E789E	NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2						protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						ACGACATTATCTCTTCTTCAA	0.493000													13	69					0	0	1	0	0
OSMR	9180	broad.mit.edu	37	5	38876452	38876452	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr5:38876452G>C	ENST00000274276.3	+	3	625	c.223G>C	c.(223-225)Gaa>Caa	p.E75Q	OSMR_ENST00000502536.1_Missense_Mutation_p.E75Q	NM_003999.2	NP_003990.1	Q99650	OSMR_HUMAN	oncostatin M receptor	75					cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	46	all_lung(31;0.000365)					CAGTAGGATTGAAACATCCAA	0.343000													10	16					0	0	1	0	0
RFC4	5984	broad.mit.edu	37	3	186507765	186507765	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr3:186507765T>C	ENST00000392481.2	-	11	1366	c.1085A>G	c.(1084-1086)aAt>aGt	p.N362S	RFC4_ENST00000433496.1_Missense_Mutation_p.N335S|RFC4_ENST00000296273.2_Missense_Mutation_p.N362S	NM_181573.2	NP_853551.1	P35249	RFC4_HUMAN	replication factor C (activator 1) 4, 37kDa	362					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|phosphatidylinositol-mediated signaling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			breast(3)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26	all_cancers(143;2.92e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)	GBM - Glioblastoma multiforme(93;0.0739)		ACGTTAACAATTCTGAGATAA	0.348000													7	19					0	0	1	0	0
SPRED3	399473	broad.mit.edu	37	19	38886205	38886205	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr19:38886205G>A	ENST00000587013.1	+	5	863	c.785G>A	c.(784-786)cGc>cAc	p.R262H	SPRED3_ENST00000586301.1_Missense_Mutation_p.R218H|SPRED3_ENST00000338502.4_Missense_Mutation_p.R218H			Q2MJR0	SPRE3_HUMAN	sprouty-related, EVH1 domain containing 3	218	Pro-rich.				multicellular organismal development					central_nervous_system(2)|large_intestine(1)|lung(5)|skin(1)	9	all_cancers(60;3.4e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			TGGGGCGGCCGCGGCTACGAG	0.731000													8	13					0	0	1	0	0
SLC9A3	6550	broad.mit.edu	37	5	476462	476462	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr5:476462G>A	ENST00000264938.3	-	13	1931	c.1922C>T	c.(1921-1923)aCg>aTg	p.T641M	CTD-2228K2.7_ENST00000606319.1_RNA|SLC9A3_ENST00000514375.1_Missense_Mutation_p.T632M|CTD-2228K2.7_ENST00000607286.1_RNA	NM_004174.2	NP_004165.2	P48764	SL9A3_HUMAN	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3	641	Interaction with PDZD3 (By similarity).					cell surface|integral to membrane	sodium:hydrogen antiporter activity			NS(2)|biliary_tract(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(2)|lung(16)|prostate(3)|skin(2)|urinary_tract(1)	37			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			CTCCGTGGGCGTGAGCTCGTG	0.622000													4	91					0	0	1	0	0
CACNA2D2	9254	broad.mit.edu	37	3	50471831	50471831	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr3:50471831C>A	ENST00000435965.1	-	3	491	c.318G>T	c.(316-318)gaG>gaT	p.E106D	CACNA2D2_ENST00000360963.3_Missense_Mutation_p.E37D|CACNA2D2_ENST00000423994.2_Missense_Mutation_p.E106D|CACNA2D2_ENST00000266039.3_Missense_Mutation_p.E106D|CACNA2D2_ENST00000429770.1_Missense_Mutation_p.E106D|CACNA2D2_ENST00000395083.1_Missense_Mutation_p.E106D|CACNA2D2_ENST00000424201.2_Missense_Mutation_p.E106D|CACNA2D2_ENST00000479441.1_Missense_Mutation_p.E106D|CACNA2D2_ENST00000487413.1_5'UTR			Q9NY47	CA2D2_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 2	106					energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			breast(3)|cervix(1)|endometrium(4)|large_intestine(4)|lung(8)|ovary(2)|prostate(4)|skin(4)|urinary_tract(1)	31				BRCA - Breast invasive adenocarcinoma(193;0.000365)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)	Gabapentin(DB00996)	TCTCCTGTACCTCGAACAGGT	0.567000													38	73					2.20474e-14	2.48511e-14	1	1	0
HUWE1	10075	broad.mit.edu	37	X	53602723	53602723	+	Silent	SNP	C	C	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chrX:53602723C>T	ENST00000342160.3	-	44	6367	c.5910G>A	c.(5908-5910)ggG>ggA	p.G1970G	HUWE1_ENST00000262854.6_Silent_p.G1970G			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	1970					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						GGGTCATAACCCCAGGTTTAG	0.438000													10	30					0	0	1	0	0
CPSF1	29894	broad.mit.edu	37	8	145625558	145625558	+	Splice_Site	SNP	A	A	G			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr8:145625558A>G	ENST00000349769.3	-	9	1032		c.e9+1		MIR1234_ENST00000408875.1_RNA	NM_013291.2	NP_037423.2	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1, 160kDa						mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			CCCCACACTCACGAAGCGGGA	0.682000													7	4					0	0	1	0	0
NEDD1	121441	broad.mit.edu	37	12	97339519	97339519	+	Missense_Mutation	SNP	C	C	T	rs78657464		TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr12:97339519C>T	ENST00000266742.4	+	14	2042	c.1703C>T	c.(1702-1704)tCa>tTa	p.S568L	NEDD1_ENST00000429527.2_Missense_Mutation_p.S568L|NEDD1_ENST00000411739.2_Missense_Mutation_p.S479L|NEDD1_ENST00000457368.2_Missense_Mutation_p.S479L|NEDD1_ENST00000557644.1_Missense_Mutation_p.S575L	NM_152905.3	NP_690869.1	Q8NHV4	NEDD1_HUMAN	neural precursor cell expressed, developmentally down-regulated 1	568					cell division|G2/M transition of mitotic cell cycle|mitosis	cytosol				breast(2)|endometrium(1)|kidney(2)|large_intestine(9)|lung(8)	22						AGTTCACTCTCAGAAAAAATA	0.368000													7	42					0	0	1	0	0
SPDYA	245711	broad.mit.edu	37	2	29045273	29045273	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr2:29045273C>T	ENST00000334056.5	+	5	566	c.377C>T	c.(376-378)gCt>gTt	p.A126V	SPDYA_ENST00000462832.1_3'UTR|SPDYA_ENST00000379579.4_Missense_Mutation_p.A126V	NM_182756.3	NP_877433.2	Q5MJ70	SPDYA_HUMAN	speedy/RINGO cell cycle regulator family member A	126	Speedy/Ringo box; Required for CDK- binding (By similarity).				G1/S transition of mitotic cell cycle|multicellular organismal development|positive regulation of cell proliferation|response to DNA damage stimulus	nucleus	protein kinase binding			cervix(1)|endometrium(1)|large_intestine(2)|lung(1)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	9	Acute lymphoblastic leukemia(172;0.155)					TTCTTTATTGCTCTGTAAGTA	0.274000													3	12					0	0	1	0	0
APBB1	322	broad.mit.edu	37	11	6432092	6432092	+	Missense_Mutation	SNP	C	C	A	rs145320037		TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr11:6432092C>A	ENST00000389906.2	-	2	585	c.486G>T	c.(484-486)gaG>gaT	p.E162D	APBB1_ENST00000609360.1_Missense_Mutation_p.E162D|APBB1_ENST00000311051.3_Missense_Mutation_p.E162D|APBB1_ENST00000299402.6_Missense_Mutation_p.E162D			O00213	APBB1_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	162	Glu-rich.				apoptosis|axonogenesis|cell cycle arrest|histone H4 acetylation|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of thymidylate synthase biosynthetic process|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|signal transduction|transcription, DNA-dependent	cytoplasm|growth cone|lamellipodium|nucleus|plasma membrane|synapse	beta-amyloid binding|chromatin binding|histone binding|proline-rich region binding|transcription factor binding	p.E162D(1)		breast(4)|endometrium(3)|kidney(1)|large_intestine(7)|lung(5)|prostate(2)|skin(1)|urinary_tract(1)	24		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;6.49e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		catcatcatcctcctcctcct	0.637000													3	43					0.004672	0.00476984	1	1	0
BIRC6	57448	broad.mit.edu	37	2	32832677	32832677	+	Silent	SNP	A	A	G			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr2:32832677A>G	ENST00000421745.2	+	72	14360	c.14226A>G	c.(14224-14226)gaA>gaG	p.E4742E		NM_016252.3	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	4742					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					CAATGCTAGAACAAATCAGAA	0.403000													11	47					0	0	1	0	0
LOC654342	654342	broad.mit.edu	37	2	91843454	91843454	+	RNA	SNP	C	C	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr2:91843454C>A	ENST00000609777.1	-	0	138																											CCCACCAACTCTTGGTACTGG	0.617000													22	77					2.27731e-05	2.37473e-05	1	1	0
CEP63	80254	broad.mit.edu	37	3	134256013	134256013	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr3:134256013C>T	ENST00000337090.3	+	6	631	c.458C>T	c.(457-459)tCg>tTg	p.S153L	CEP63_ENST00000606977.1_Missense_Mutation_p.S153L|CEP63_ENST00000354446.3_Missense_Mutation_p.S153L|CEP63_ENST00000383229.3_Missense_Mutation_p.S153L|CEP63_ENST00000513612.2_Missense_Mutation_p.S153L|CEP63_ENST00000332047.5_Missense_Mutation_p.S153L			Q96MT8	CEP63_HUMAN	centrosomal protein 63kDa	153					cell division|DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitosis|signal transduction in response to DNA damage|spindle assembly	centrosome|cytosol|spindle pole	protein binding	p.S153L(1)		kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27						CGTCAGAAATCGCTGGACTGG	0.438000													18	57					0	0	1	0	0
RDX	5962	broad.mit.edu	37	11	110104203	110104203	+	Splice_Site	SNP	G	G	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr11:110104203G>T	ENST00000343115.4	-	13	1665	c.1346C>A	c.(1345-1347)gCt>gAt	p.A449D	RDX_ENST00000405097.1_Splice_Site_p.A449D|RDX_ENST00000544551.1_Splice_Site_p.A313D|RDX_ENST00000530301.1_Intron|RDX_ENST00000528900.1_Splice_Site_p.A102D|RDX_ENST00000528498.1_Splice_Site_p.A449D	NM_001260494.1|NM_002906.3	NP_001247423.1|NP_002897.1	P35241	RADI_HUMAN	radixin	449	Glu-rich.				actin filament capping	cleavage furrow|cytoskeleton|extrinsic to membrane|Golgi apparatus|nucleolus|plasma membrane	actin binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(8)|skin(1)|urinary_tract(1)	18		all_cancers(61;7.18e-13)|all_epithelial(67;2.61e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.13e-06)|BRCA - Breast invasive adenocarcinoma(274;9.75e-06)|all cancers(92;5.9e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0248)		GGCTGCAAAAGCCTGAACATT	0.383000													5	44					0.0215528	0.0216639	1	1	0
TPPP	11076	broad.mit.edu	37	5	666141	666141	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr5:666141C>T	ENST00000360578.5	-	3	530	c.409G>A	c.(409-411)Gtt>Att	p.V137I	CEP72_ENST00000514507.1_3'UTR	NM_007030.2	NP_008961.1	O94811	TPPP_HUMAN	tubulin polymerization promoting protein	137					microtubule bundle formation|microtubule polymerization|positive regulation of protein polymerization	nucleus|perinuclear region of cytoplasm|soluble fraction	calcium ion binding|microtubule binding			kidney(1)|large_intestine(1)|lung(2)|prostate(1)	5		Ovarian(839;0.0563)	Epithelial(17;0.000445)|all cancers(22;0.00176)|OV - Ovarian serous cystadenocarcinoma(19;0.00227)|Lung(60;0.0863)	GBM - Glioblastoma multiforme(108;0.0191)		ACCTCGCGAACGGCCTCCTCG	0.642000													22	96					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	147183135	147183135	+	Splice_Site	SNP	T	T	C			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr7:147183135T>C	ENST00000361727.3	+	11	2293		c.e11+2			NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2						behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GCCACAACTGTGAGTGCCAAT	0.443000										HNSCC(39;0.1)			5	27					0	0	1	0	0
RNF168	165918	broad.mit.edu	37	3	196210763	196210763	+	Splice_Site	SNP	C	C	G			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr3:196210763C>G	ENST00000318037.3	-	4	1153		c.e4-1			NM_152617.3	NP_689830.2	Q8IYW5	RN168_HUMAN	ring finger protein 168, E3 ubiquitin protein ligase						double-strand break repair|histone H2A K63-linked ubiquitination|positive regulation of DNA repair|response to ionizing radiation	nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|endometrium(2)|large_intestine(7)|lung(9)|ovary(1)	20	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;5.25e-24)|all cancers(36;5.47e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00348)		AGAAATTGTTCTTCAACAATA	0.323000													29	77					0	0	1	0	0
RGN	9104	broad.mit.edu	37	X	46951124	46951124	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chrX:46951124G>A	ENST00000397180.1	+	6	1579	c.610G>A	c.(610-612)Gat>Aat	p.D204N	RGN_ENST00000336169.3_Missense_Mutation_p.D204N|RGN_ENST00000457380.1_Missense_Mutation_p.D132N|RGN_ENST00000352078.4_Missense_Mutation_p.D204N	NM_152869.2	NP_690608.1	Q15493	RGN_HUMAN	regucalcin	204					cellular calcium ion homeostasis|positive regulation of ATPase activity|regulation of calcium-mediated signaling	cytoplasm|nucleus	calcium ion binding|enzyme regulator activity|gluconolactonase activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(1)|lung(2)|skin(1)|urinary_tract(1)	9						ACAAATCCCAGATGGAATGTG	0.448000													18	57					0	0	1	0	0
CD74	972	broad.mit.edu	37	5	149782802	149782802	+	Silent	SNP	G	G	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr5:149782802G>A	ENST00000009530.7	-	7	700	c.699C>T	c.(697-699)gaC>gaT	p.D233D	CD74_ENST00000353334.6_Intron|CD74_ENST00000524315.1_Intron|CD74_ENST00000377795.3_Intron			P04233	HG2A_HUMAN	CD74 molecule, major histocompatibility complex, class II invariant chain	233	Thyroglobulin type-1.				antigen processing and presentation of endogenous antigen|cell proliferation|immunoglobulin mediated immune response|intracellular protein transport|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of peptide secretion|positive regulation of B cell proliferation|positive regulation of chemokine (C-X-C motif) ligand 2 production|positive regulation of cytokine-mediated signaling pathway|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|positive regulation of macrophage cytokine production|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation|prostaglandin biosynthetic process|protein complex assembly|regulation of macrophage activation	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|lysosome|receptor complex	beta-amyloid binding|cytokine receptor activity|identical protein binding|MHC class II protein binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)	5		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGCCGTTCTCGTCGCACTTGG	0.597000			T	ROS1	NSCLC								6	168					0	0	1	0	0
NAV1	89796	broad.mit.edu	37	1	201751889	201751889	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr1:201751889C>T	ENST00000367296.4	+	6	2669	c.2249C>T	c.(2248-2250)tCa>tTa	p.S750L	NAV1_ENST00000469130.1_3'UTR|NAV1_ENST00000367297.4_Missense_Mutation_p.S750L|IPO9-AS1_ENST00000413035.1_RNA|NAV1_ENST00000367300.3_Missense_Mutation_p.S750L|NAV1_ENST00000367302.1_Missense_Mutation_p.S763L|NAV1_ENST00000295624.6_Missense_Mutation_p.S750L|NAV1_ENST00000367295.1_Missense_Mutation_p.S359L	NM_020443.4	NP_065176.3	Q8NEY1	NAV1_HUMAN	neuron navigator 1	750					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			breast(5)|central_nervous_system(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(10)|lung(29)|ovary(4)|prostate(3)|skin(1)|stomach(2)	70						GCCTTGGACTCAGACAACATC	0.572000													7	65					0	0	1	0	0
PCDH10	57575	broad.mit.edu	37	4	134071867	134071867	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr4:134071867G>C	ENST00000264360.5	+	1	1398	c.572G>C	c.(571-573)cGa>cCa	p.R191P		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10		Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		CCACTGGACCGAGAGCAGCAA	0.657000													11	62					0	0	1	0	0
ANKRD35	148741	broad.mit.edu	37	1	145562608	145562608	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr1:145562608G>T	ENST00000355594.4	+	10	2383	c.2296G>T	c.(2296-2298)Gag>Tag	p.E766*		NM_144698.3	NP_653299.4	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	766										NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(9)|lung(16)|ovary(4)|prostate(3)|skin(2)|urinary_tract(1)	47	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CCCGTGTAGGGAGCCAGGCAC	0.652000													7	10					0.0293803	0.0293803	1	1	0
CLCN2	1181	broad.mit.edu	37	3	184075768	184075768	+	Silent	SNP	C	C	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr3:184075768C>T	ENST00000265593.4	-	5	768	c.597G>A	c.(595-597)ggG>ggA	p.G199G	CLCN2_ENST00000434054.2_Silent_p.G155G|CLCN2_ENST00000457512.1_Silent_p.G199G|EIF2B5_ENST00000444495.1_Intron|CLCN2_ENST00000423355.2_5'UTR|CLCN2_ENST00000344937.7_Silent_p.G199G	NM_004366.5	NP_004357.3	P51788	CLCN2_HUMAN	chloride channel, voltage-sensitive 2	199			G -> A (no effect).			chloride channel complex	voltage-gated chloride channel activity			breast(2)|central_nervous_system(4)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	27	all_cancers(143;6.66e-11)|Ovarian(172;0.0339)		Epithelial(37;2.22e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Lubiprostone(DB01046)	CAAGCGGCATCCCGCTGCCTA	0.592000													17	41					0	0	1	0	0
TICAM1	148022	broad.mit.edu	37	19	4817573	4817573	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr19:4817573G>C	ENST00000248244.5	-	2	1046	c.817C>G	c.(817-819)Cct>Gct	p.P273A		NM_182919.3	NP_891549.1	Q8IUC6	TCAM1_HUMAN	toll-like receptor adaptor molecule 1	273	Pro-rich.				apoptosis|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein kinase binding|signal transducer activity			NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	26				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		GGAAGCCCAGGAGGTGGGCTG	0.667000													17	28					0	0	1	0	0
VGF	7425	broad.mit.edu	37	7	100806828	100806828	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr7:100806828C>G	ENST00000249330.2	-	2	1536	c.1297G>C	c.(1297-1299)Gag>Cag	p.E433Q	VGF_ENST00000445482.2_Missense_Mutation_p.E433Q	NM_003378.3	NP_003369.2	O15240	VGF_HUMAN	VGF nerve growth factor inducible	433	Asp/Glu-rich (acidic).				response to cAMP	extracellular space|transport vesicle	growth factor activity			cervix(1)|large_intestine(1)|lung(4)|prostate(2)|skin(1)	9	Lung NSC(181;0.168)|all_lung(186;0.215)					tctgtcccctcggcctccttc	0.687000													3	14					0	0	1	0	0
HIST1H2AJ	8331	broad.mit.edu	37	6	27782430	27782430	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr6:27782430C>T	ENST00000333151.3	-	1	177	c.89G>A	c.(88-90)cGa>cAa	p.R30Q		NM_021066.2	NP_066544.1	Q99878	H2A1J_HUMAN	histone cluster 1, H2aj	30					nucleosome assembly	nucleosome|nucleus	DNA binding	p.R30Q(1)		NS(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(2)	11						GCGATGCACTCGGCCTACGGG	0.652000													23	41					0	0	1	0	0
SSTR2	6752	broad.mit.edu	37	17	71166025	71166025	+	Silent	SNP	G	G	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr17:71166025G>A	ENST00000357585.2	+	2	936	c.567G>A	c.(565-567)ggG>ggA	p.G189G	SSTR2_ENST00000315332.2_Silent_p.G189G|RP11-143K11.5_ENST00000580671.1_RNA	NM_001050.2	NP_001041.1	P30874	SSR2_HUMAN	somatostatin receptor 2	189					digestion|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	PDZ domain binding|somatostatin receptor activity			endometrium(2)|large_intestine(5)|lung(2)|prostate(2)	11			LUSC - Lung squamous cell carcinoma(166;0.197)			ACCAGTGGGGGAGAAGCAGCT	0.562000													7	71					0	0	1	0	0
FSHR	2492	broad.mit.edu	37	2	49190754	49190754	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr2:49190754G>T	ENST00000406846.2	-	10	1325	c.1206C>A	c.(1204-1206)tgC>tgA	p.C402*	FSHR_ENST00000346173.3_Nonsense_Mutation_p.C340*|FSHR_ENST00000541117.1_Nonsense_Mutation_p.C138*|FSHR_ENST00000304421.4_Nonsense_Mutation_p.C376*	NM_000145.3	NP_000136.2	P23945	FSHR_HUMAN	follicle stimulating hormone receptor	402					female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|liver(1)|lung(45)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	73		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	AGGCCAGGTTGCACATAAGGA	0.448000									Gonadal Dysgenesis, 46 XX				30	59					5.52252e-06	5.88465e-06	1	1	0
STIP1	10963	broad.mit.edu	37	11	63962054	63962054	+	Silent	SNP	G	G	C			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr11:63962054G>C	ENST00000358794.5	+	4	1159	c.606G>C	c.(604-606)ctG>ctC	p.L202L	STIP1_ENST00000305218.4_Silent_p.L155L|STIP1_ENST00000543847.1_Silent_p.L155L|STIP1_ENST00000538945.1_Silent_p.L131L|STIP1_ENST00000540501.1_3'UTR	NM_001282652.1	NP_001269581.1	P31948	STIP1_HUMAN	stress-induced-phosphoprotein 1	155					axon guidance|response to stress	Golgi apparatus|nucleus				endometrium(4)|large_intestine(3)|liver(1)|lung(15)|ovary(2)|prostate(1)|skin(1)	27						ACCGGGAGCTGATAGAGCAGC	0.483000													16	34					0	0	1	0	0
TMPRSS9	360200	broad.mit.edu	37	19	2408525	2408525	+	Silent	SNP	C	C	T	rs141252745		TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr19:2408525C>T	ENST00000332578.3	+	7	912	c.912C>T	c.(910-912)ttC>ttT	p.F304F		NM_182973.1	NP_892018.1	Q7Z410	TMPS9_HUMAN	transmembrane protease, serine 9	304	Peptidase S1 1.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCTGCCTTTCGGCCGGCACA	0.642000													39	92					0	0	1	0	0
TICAM1	148022	broad.mit.edu	37	19	4817244	4817244	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr19:4817244G>C	ENST00000248244.5	-	2	1375	c.1146C>G	c.(1144-1146)ttC>ttG	p.F382L		NM_182919.3	NP_891549.1	Q8IUC6	TCAM1_HUMAN	toll-like receptor adaptor molecule 1	382					apoptosis|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein kinase binding|signal transducer activity			NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	26				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		GGGAGGAAGGGAACAGGGAGG	0.572000													18	29					0	0	1	0	0
FAM110C	642273	broad.mit.edu	37	2	45442	45442	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr2:45442C>T	ENST00000327669.4	-	1	943	c.944G>A	c.(943-945)cGa>cAa	p.R315Q		NM_001077710.2	NP_001071178.2	Q1W6H9	F110C_HUMAN	family with sequence similarity 110, member C	315						microtubule|microtubule organizing center|spindle pole				central_nervous_system(1)|kidney(1)|lung(2)	4	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.00221)		all cancers(51;0.000815)|Epithelial(75;0.00379)|OV - Ovarian serous cystadenocarcinoma(76;0.0127)|GBM - Glioblastoma multiforme(21;0.232)		GCACACACCTCGGGTCCGGCT	0.632000													17	52					0	0	1	0	0
ZEB2	9839	broad.mit.edu	37	2	145156270	145156270	+	Missense_Mutation	SNP	T	T	G			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr2:145156270T>G	ENST00000558170.2	-	8	3668	c.2484A>C	c.(2482-2484)aaA>aaC	p.K828N	ZEB2_ENST00000539609.3_Missense_Mutation_p.K804N|ZEB2_ENST00000409487.3_Missense_Mutation_p.K828N|ZEB2_ENST00000303660.4_Missense_Mutation_p.K828N	NM_014795.3	NP_055610.1	O60315	ZEB2_HUMAN	zinc finger E-box binding homeobox 2	828						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(7)|kidney(6)|large_intestine(23)|lung(45)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	107				BRCA - Breast invasive adenocarcinoma(221;0.112)		CTATAATACTTTTGGGTTCTT	0.398000													14	70					0	0	1	0	0
PSMC5	5705	broad.mit.edu	37	17	61908904	61908904	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr17:61908904G>A	ENST00000310144.6	+	10	1316	c.1008G>A	c.(1006-1008)atG>atA	p.M336I	PSMC5_ENST00000581882.1_Missense_Mutation_p.M328I|PSMC5_ENST00000580864.1_Missense_Mutation_p.M328I|PSMC5_ENST00000375812.4_Missense_Mutation_p.M328I	NM_002805.5	NP_002796.4	P62195	PRS8_HUMAN	proteasome (prosome, macropain) 26S subunit, ATPase, 5	336					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of programmed cell death|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|transcription from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|ATPase activity|thyrotropin-releasing hormone receptor binding|transcription cofactor activity|transcription factor binding			endometrium(3)|kidney(2)|large_intestine(8)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	20						CTCGGAAGATGAACCTGACCC	0.547000													25	91					0	0	1	0	0
SHROOM3	57619	broad.mit.edu	37	4	77660869	77660869	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr4:77660869G>C	ENST00000296043.6	+	5	2496	c.1543G>C	c.(1543-1545)Gat>Cat	p.D515H		NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	515					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			GGCTACCATTGATGAGAATGG	0.532000													39	105					0	0	1	0	0
ICAM1	3383	broad.mit.edu	37	19	10395175	10395175	+	Missense_Mutation	SNP	C	C	T	rs141326678		TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr19:10395175C>T	ENST00000264832.3	+	5	1347	c.1022C>T	c.(1021-1023)aCg>aTg	p.T341M	CTD-2369P2.5_ENST00000592893.1_RNA|ICAM1_ENST00000423829.2_Missense_Mutation_p.T119M	NM_000201.2	NP_000192.2	P05362	ICAM1_HUMAN	intercellular adhesion molecule 1	341	Ig-like C2-type 4.				adhesion to symbiont|heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking|positive regulation of cellular extravasation|regulation of immune response|regulation of leukocyte mediated cytotoxicity|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|virion attachment, binding of host cell surface receptor	extracellular space|integral to plasma membrane	integrin binding|transmembrane receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(20;1.39e-09)|Epithelial(33;2.81e-06)|all cancers(31;6.56e-06)		Natalizumab(DB00108)|Simvastatin(DB00641)	GCCAAGGTGACGCTGAATGGG	0.642000													29	95					0	0	1	0	0
BPTF	2186	broad.mit.edu	37	17	65942319	65942319	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr17:65942319G>A	ENST00000321892.4	+	23	7934	c.7873G>A	c.(7873-7875)Gag>Aag	p.E2625K	BPTF_ENST00000424123.3_Intron|BPTF_ENST00000306378.6_Missense_Mutation_p.E2499K|BPTF_ENST00000335221.5_Intron			Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	2625					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(23)|ovary(3)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	78	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			CAGTGTGCAAGAGCAGTTGCA	0.458000													20	77					0	0	1	0	0
PLIN4	729359	broad.mit.edu	37	19	4516678	4516678	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr19:4516678G>A	ENST00000301286.3	-	2	163	c.164C>T	c.(163-165)cCa>cTa	p.P55L		NM_001080400.1	NP_001073869.1	Q96Q06	PLIN4_HUMAN	perilipin 4	55						lipid particle|plasma membrane				NS(2)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|soft_tissue(1)|stomach(2)	41						CGTCTGCTCTGGGTGGGCAGC	0.632000													5	12					0	0	1	0	0
NT5C1B	93034	broad.mit.edu	37	2	18765819	18765819	+	Silent	SNP	C	C	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr2:18765819C>T	ENST00000304081.4	-	4	784	c.684G>A	c.(682-684)tcG>tcA	p.S228S	NT5C1B_ENST00000600945.1_Silent_p.S288S|NT5C1B-RDH14_ENST00000532967.1_Silent_p.S288S|NT5C1B_ENST00000359846.2_Silent_p.S288S	NM_033253.3	NP_150278.2			5'-nucleotidase, cytosolic IB											endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				TCTCGTAGAACGACCTCATGG	0.692000													5	21					0	0	1	0	0
JPH2	57158	broad.mit.edu	37	20	42788265	42788265	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr20:42788265C>T	ENST00000372980.3	-	2	2034	c.1162G>A	c.(1162-1164)Gcc>Acc	p.A388T		NM_020433.4	NP_065166.2	Q9BR39	JPH2_HUMAN	junctophilin 2	388	Ala-rich.				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane				NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(19)|prostate(1)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			TACCTGGAGGCGGCAATCTCG	0.677000													10	23					0	0	1	0	0
ZNF45	7596	broad.mit.edu	37	19	44423762	44423762	+	Missense_Mutation	SNP	A	A	C			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr19:44423762A>C	ENST00000269973.5	-	8	1195	c.105T>G	c.(103-105)gaT>gaG	p.D35E	ZNF45_ENST00000589703.1_Missense_Mutation_p.D35E|RP11-15A1.2_ENST00000586247.1_RNA	NM_003425.3	NP_003416.1	Q02386	ZNF45_HUMAN	zinc finger protein 45	35	KRAB.				multicellular organismal development	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	17						CCAGCATCACATCTCGGTACA	0.527000													24	217					0	0	1	0	0
TNC	3371	broad.mit.edu	37	9	117840333	117840333	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr9:117840333C>T	ENST00000350763.4	-	7	2974	c.2563G>A	c.(2563-2565)Gag>Aag	p.E855K	TNC_ENST00000542877.1_Missense_Mutation_p.E855K|TNC_ENST00000340094.3_Missense_Mutation_p.E855K|TNC_ENST00000535648.1_Missense_Mutation_p.E855K|TNC_ENST00000537320.1_Missense_Mutation_p.E855K|TNC_ENST00000345230.3_Missense_Mutation_p.E855K|TNC_ENST00000341037.4_Missense_Mutation_p.E855K|TNC_ENST00000423613.2_Missense_Mutation_p.E855K|TNC_ENST00000346706.3_Missense_Mutation_p.E855K	NM_002160.3	NP_002151.2	P24821	TENA_HUMAN	tenascin C	855	Fibronectin type-III 3.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			NS(3)|breast(5)|central_nervous_system(4)|endometrium(8)|kidney(6)|large_intestine(32)|liver(1)|lung(39)|ovary(1)|pancreas(2)|prostate(5)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	120						TACTGGTTCTCGTCCTCTGTG	0.562000													20	24					0	0	1	0	0
SUSD5	26032	broad.mit.edu	37	3	33249376	33249376	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr3:33249376C>G	ENST00000309558.3	-	3	750	c.333G>C	c.(331-333)atG>atC	p.M111I		NM_015551.1	NP_056366.1	O60279	SUSD5_HUMAN	sushi domain containing 5	111	Link.				cell adhesion	integral to membrane	hyaluronic acid binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						CGACAGCTCTCATGATTTGCT	0.423000													6	56					0	0	1	0	0
C1orf159	54991	broad.mit.edu	37	1	1019691	1019691	+	Silent	SNP	G	G	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr1:1019691G>A	ENST00000448924.1	-	10	1083	c.652C>T	c.(652-654)Ctg>Ttg	p.L218L	C1orf159_ENST00000379339.1_Silent_p.L218L|C1orf159_ENST00000294576.5_Silent_p.L182L|C1orf159_ENST00000421241.2_Intron|C1orf159_ENST00000482816.1_Intron|C1orf159_ENST00000379319.1_Intron|C1orf159_ENST00000379320.1_Silent_p.L182L			Q96HA4	CA159_HUMAN	chromosome 1 open reading frame 159	218						integral to membrane						all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.96e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.77e-22)|Colorectal(212;6.51e-05)|COAD - Colon adenocarcinoma(227;0.000214)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|Kidney(185;0.00254)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		GACTGGCCCAGAGATGGGAAA	0.627000													14	41					0	0	1	0	0
FLII	2314	broad.mit.edu	37	17	18154205	18154205	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr17:18154205C>G	ENST00000327031.4	-	14	1948	c.1723G>C	c.(1723-1725)Gag>Cag	p.E575Q	FLII_ENST00000579294.1_Missense_Mutation_p.E564Q|FLII_ENST00000379450.4_Missense_Mutation_p.E489Q|FLII_ENST00000578558.1_Missense_Mutation_p.E574Q|FLII_ENST00000545457.2_Missense_Mutation_p.E520Q	NM_002018.3	NP_002009.1	Q13045	FLII_HUMAN	flightless I homolog (Drosophila)	575	Interaction with ACTL6A.				multicellular organismal development|muscle contraction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	actin binding			central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32	all_neural(463;0.228)					GTGCGGCACTCAGCACCCAGG	0.602000													42	71					0	0	1	0	0
OR4C15	81309	broad.mit.edu	37	11	55322409	55322409	+	Silent	SNP	C	C	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr11:55322409C>T	ENST00000314644.2	+	1	627	c.627C>T	c.(625-627)tcC>tcT	p.S209S		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	155					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						TCTTGCATTCCATGATACAAA	0.478000										HNSCC(20;0.049)			17	62					0	0	1	0	0
FGFR2	2263	broad.mit.edu	37	10	123258070	123258070	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr10:123258070C>T	ENST00000358487.5	-	12	1883	c.1611G>A	c.(1609-1611)atG>atA	p.M537I	FGFR2_ENST00000360144.3_Missense_Mutation_p.M449I|FGFR2_ENST00000369060.4_Missense_Mutation_p.M421I|FGFR2_ENST00000346997.2_Missense_Mutation_p.M535I|FGFR2_ENST00000369061.4_Missense_Mutation_p.M425I|FGFR2_ENST00000369059.1_Missense_Mutation_p.M423I|FGFR2_ENST00000351936.6_Missense_Mutation_p.M535I|FGFR2_ENST00000478859.1_Missense_Mutation_p.M309I|FGFR2_ENST00000457416.2_Missense_Mutation_p.M538I|FGFR2_ENST00000356226.4_Missense_Mutation_p.M420I|FGFR2_ENST00000369056.1_Missense_Mutation_p.M538I|FGFR2_ENST00000357555.5_Missense_Mutation_p.M448I	NM_000141.4	NP_000132.3	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2	537	Protein kinase.				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding	p.M448I(1)|p.M535I(1)|p.M537I(1)|p.M538I(1)		breast(3)|central_nervous_system(3)|cervix(2)|endometrium(98)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(7)|lung(21)|ovary(4)|skin(30)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(2)	181		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	TCATCTTCATCATCTCCATCT	0.418000		5	Mis		"""gastric. NSCLC, endometrial"""		"""Crouzon, Pfeiffer, and Apert syndromes"""		Saethre-Chotzen syndrome;Apert syndrome				12	46					0	0	1	0	0
SIM2	6493	broad.mit.edu	37	21	38072071	38072071	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr21:38072071G>A	ENST00000290399.6	+	1	638	c.25G>A	c.(25-27)Gcc>Acc	p.A9T	AP000697.6_ENST00000430607.1_RNA|SIM2_ENST00000430056.3_Missense_Mutation_p.A9T|SIM2_ENST00000460783.1_3'UTR	NM_005069.3	NP_005060.1	Q14190	SIM2_HUMAN	single-minded family bHLH transcription factor 2	9					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(6)|prostate(1)|skin(2)	16						CAAGAATGCGGCCAAGACCAG	0.652000													4	45					0	0	1	0	0
TBC1D9B	23061	broad.mit.edu	37	5	179290809	179290809	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr5:179290809C>T	ENST00000356834.3	-	22	3429	c.3392G>A	c.(3391-3393)gGc>gAc	p.G1131D	TBC1D9B_ENST00000518085.1_5'UTR|TBC1D9B_ENST00000444477.2_Missense_Mutation_p.G272D|TBC1D9B_ENST00000519746.1_Missense_Mutation_p.G290D|TBC1D9B_ENST00000355235.3_Missense_Mutation_p.G1114D	NM_198868.2	NP_942568.2	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	1131						integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	28	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTCGCCGCTGCCCCCCTCCAC	0.642000													4	106					0	0	1	0	0
PCP4L1	654790	broad.mit.edu	37	1	161254154	161254156	+	In_Frame_Del	DEL	GGA	GGA	-			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr1:161254154_161254156delGGA	ENST00000504449.1	+	3	338_340	c.90_92delGGA	c.(88-93)gcggag>gcg	p.E35del		NM_001102566.1	NP_001096036.1	A6NKN8	PC4L1_HUMAN	Purkinje cell protein 4 like 1	35								p.A30A(1)|p.E35delE(1)		endometrium(1)|kidney(1)|large_intestine(1)|lung(1)	4	all_cancers(52;4.16e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			TCAAGAAGGCGGAGGAGGAGGAG	0.488													8	339	---	---	---	---					
NOS1AP	9722	broad.mit.edu	37	1	162326888	162326890	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr1:162326888_162326890delCAG	ENST00000361897.5	+	8	1303_1305	c.901_903delCAG	c.(901-903)cagdel	p.Q306del	NOS1AP_ENST00000530878.1_In_Frame_Del_p.Q301del	NM_001164757.1|NM_014697.2	NP_001158229.1|NP_055512.1	O75052	CAPON_HUMAN	nitric oxide synthase 1 (neuronal) adaptor protein	306	Poly-Gln.				regulation of apoptosis|regulation of nitric oxide biosynthetic process|regulation of nitric-oxide synthase activity		nitric-oxide synthase binding|PDZ domain binding			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(12)|skin(1)|upper_aerodigestive_tract(2)	32	all_hematologic(112;0.203)		BRCA - Breast invasive adenocarcinoma(70;0.0537)			gcagctcctccagcagcAGCAGC	0.611													9	249	---	---	---	---					
TMEM229A	730130	broad.mit.edu	37	7	123672457	123672459	+	In_Frame_Del	DEL	GCT	GCT	-	rs72310362		TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr7:123672457_123672459delGCT	ENST00000455783.1	-	1	1064_1066	c.599_601delAGC	c.(598-603)cagcgg>cgg	p.Q200del	RP5-921G16.1_ENST00000484322.1_RNA	NM_001136002.1	NP_001129474.1	B2RXF0	T229A_HUMAN	transmembrane protein 229A	200						host cell nucleus|integral to membrane	sequence-specific DNA binding transcription factor activity			endometrium(3)|kidney(3)	6						GCGCCCCTCCgctgctgctgctg	0.754													2	4	---	---	---	---					
RP11-597A11.1	0	broad.mit.edu	37	14	20086237	20086237	+	RNA	DEL	T	T	-			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr14:20086237delT	ENST00000548261.1	+	0	51																											GGTGTGTGTGTGGGGGGGTAT	0.388													4	9	---	---	---	---					
ANKRD20A18P	391269	broad.mit.edu	37	21	15436915	15436915	+	RNA	DEL	G	G	-			TCGA-FD-A5BZ-01A-11D-A289-08	TCGA-FD-A5BZ-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6ebebc76-bf34-434d-9431-083319f71255	44546828-fa6f-4fcc-931e-b58ffd5e0d0e	g.chr21:15436915delG	ENST00000428809.1	+	0	177				AP001347.6_ENST00000432621.1_RNA|AP001347.6_ENST00000448463.1_RNA																							CCCCTGGGACGGGGGCCTTGG	0.687													3	4	---	---	---	---