Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
DGKA	1606	broad.mit.edu	37	12	56335361	56335361	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr12:56335361G>C	ENST00000331886.5	+	15	1697	c.1243G>C	c.(1243-1245)Gag>Cag	p.E415Q	DGKA_ENST00000394147.1_Missense_Mutation_p.E415Q|DGKA_ENST00000549079.2_3'UTR|DGKA_ENST00000551156.1_Missense_Mutation_p.E415Q	NM_001345.4	NP_001336.2	P23743	DGKA_HUMAN	diacylglycerol kinase, alpha 80kDa	415	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(1)|endometrium(3)|large_intestine(1)|lung(11)|ovary(4)|pancreas(1)|skin(3)|urinary_tract(1)	25					Vitamin E(DB00163)	GGATGGTCCTGAGATAGGGTG	0.468000													22	76					0	0	1	0	0
ZKSCAN5	23660	broad.mit.edu	37	7	99103931	99103931	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr7:99103931G>T	ENST00000394170.2	+	2	515	c.264G>T	c.(262-264)caG>caT	p.Q88H	ZKSCAN5_ENST00000451158.1_Missense_Mutation_p.Q88H|ZKSCAN5_ENST00000326775.5_Missense_Mutation_p.Q88H	NM_014569.3	NP_055384.1	Q9Y2L8	ZKSC5_HUMAN	zinc finger with KRAB and SCAN domains 5	88	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	21	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					CGAAGGAGCAGATCCTGGAGC	0.612000													21	70					2.98393e-07	3.1328e-07	1	1	0
SYNE3	161176	broad.mit.edu	37	14	95912406	95912406	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr14:95912406C>T	ENST00000334258.5	-	8	1486	c.1472G>A	c.(1471-1473)cGc>cAc	p.R491H	SYNE3_ENST00000554873.1_Missense_Mutation_p.R248H|SYNE3_ENST00000553340.1_Missense_Mutation_p.R491H|SYNE3_ENST00000557275.1_Missense_Mutation_p.R491H	NM_152592.3	NP_689805.3			spectrin repeat containing, nuclear envelope family member 3											breast(1)|endometrium(2)|lung(25)	28						CTCTTTCAGGCGGGAGCTTTC	0.592000													24	87					0	0	1	0	0
AMPD2	271	broad.mit.edu	37	1	110172445	110172445	+	Silent	SNP	G	G	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr1:110172445G>T	ENST00000256578.3	+	15	2412	c.2052G>T	c.(2050-2052)ctG>ctT	p.L684L	AMPD2_ENST00000528667.1_Silent_p.L684L|RP5-1160K1.6_ENST00000369843.3_RNA|AMPD2_ENST00000526301.1_3'UTR|AMPD2_ENST00000358729.4_Silent_p.L609L|AMPD2_ENST00000528454.1_Silent_p.L566L|AMPD2_ENST00000342115.4_Silent_p.L603L|AMPD2_ENST00000393688.3_Silent_p.L565L	NM_004037.7	NP_004028.3	Q01433	AMPD2_HUMAN	adenosine monophosphate deaminase 2	684					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			breast(1)|large_intestine(3)|ovary(2)|skin(1)	7		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.0425)|all cancers(265;0.0884)|Colorectal(144;0.109)|Epithelial(280;0.111)|LUSC - Lung squamous cell carcinoma(189;0.228)		CGTTTGTGCTGAGGCCACACT	0.632000													23	57					1.96895e-08	2.08072e-08	1	1	0
STEAP1B	256227	broad.mit.edu	37	7	22532225	22532225	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr7:22532225C>T	ENST00000404369.4	-	4	1136	c.721G>A	c.(721-723)Gtg>Atg	p.V241M	STEAP1B_ENST00000406890.2_Missense_Mutation_p.V222M	NM_001164460.1	NP_001157932.1	Q6NZ63	STEAL_HUMAN	STEAP family member 1B	222						integral to membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity			endometrium(1)|kidney(1)|lung(2)	4						GAGTCACTCACAGATGGAATA	0.368000													6	18					0	0	1	0	0
ZWILCH	55055	broad.mit.edu	37	15	66821195	66821195	+	Silent	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr15:66821195G>A	ENST00000307897.5	+	11	1355	c.975G>A	c.(973-975)ttG>ttA	p.L325L	ZWILCH_ENST00000446801.2_Silent_p.L211L|ZWILCH_ENST00000535141.2_Silent_p.L211L|ZWILCH_ENST00000565627.1_Silent_p.L211L	NM_017975.3	NP_060445.3	Q9H900	ZWILC_HUMAN	zwilch kinetochore protein	325					cell division|mitotic cell cycle checkpoint|mitotic prometaphase	condensed chromosome kinetochore|cytosol	protein binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|liver(1)|lung(6)|ovary(1)	18						TTCAGACCTTGAAGCATGACA	0.388000													7	18					0	0	1	0	0
SYNGAP1	8831	broad.mit.edu	37	6	33405739	33405739	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr6:33405739C>G	ENST00000418600.2	+	8	1158	c.1057C>G	c.(1057-1059)Ctg>Gtg	p.L353V	SYNGAP1_ENST00000293748.5_Missense_Mutation_p.L353V|SYNGAP1_ENST00000428982.2_Missense_Mutation_p.L294V|SYNGAP1_ENST00000496374.1_3'UTR	NM_006772.2	NP_006763.2	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1	353					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(15)|ovary(7)|pancreas(1)|stomach(1)|urinary_tract(1)	43						AGTGGCCACCCTGGCTGGGCG	0.642000													18	28					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100349659	100349659	+	RNA	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr7:100349659C>T	ENST00000542585.1	+	0	2079				ZAN_ENST00000538115.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000449052.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			ACCATTCCCTCAGAAAAACCC	0.522000													25	59					0	0	1	0	0
GCFC2	6936	broad.mit.edu	37	2	75900572	75900572	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr2:75900572C>G	ENST00000321027.3	-	13	2020	c.1887G>C	c.(1885-1887)aaG>aaC	p.K629N	GCFC2_ENST00000409857.3_Missense_Mutation_p.K591N|MRPL19_ENST00000358788.6_Intron|GCFC2_ENST00000541687.1_3'UTR	NM_001201334.1|NM_003203.4	NP_001188263.1|NP_003194.3	P16383	GCF_HUMAN	GC-rich sequence DNA-binding factor 2	629					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity										GCGCTTACCTCTTTGGATACA	0.294000													3	4					0	0	1	0	0
ABHD16A	7920	broad.mit.edu	37	6	31658330	31658330	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr6:31658330G>A	ENST00000375842.4	-	10	1222	c.236C>T	c.(235-237)tCc>tTc	p.S79F	ABHD16A_ENST00000395952.3_Missense_Mutation_p.S298F|XXbac-BPG32J3.20_ENST00000461287.1_3'UTR|ABHD16A_ENST00000440843.2_Missense_Mutation_p.S265F			O95870	ABHGA_HUMAN	abhydrolase domain containing 16A	298						integral to membrane	hydrolase activity|protein binding			endometrium(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)	10						CAGGGGCGTGGAGACGCAGCC	0.597000													18	41					0	0	1	0	0
ITIH3	3699	broad.mit.edu	37	3	52836817	52836817	+	Silent	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:52836817G>A	ENST00000449956.2	+	13	1710	c.1704G>A	c.(1702-1704)gaG>gaA	p.E568E	ITIH3_ENST00000416872.2_Intron	NM_002217.3	NP_002208.3	Q06033	ITIH3_HUMAN	inter-alpha-trypsin inhibitor heavy chain 3	568					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(6)|ovary(2)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	25				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		AGCTGCTGGAGAAGCGGTGAG	0.617000													6	12					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49447425	49447425	+	Splice_Site	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr12:49447425C>T	ENST00000301067.7	-	6	673		c.e6-1			NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		CGAGCCTCCTCTGCAGGGGGT	0.557000													3	7					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26247497	26247497	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr22:26247497C>T	ENST00000335473.7	+	21	4086	c.3836C>T	c.(3835-3837)cCa>cTa	p.P1279L	MYO18B_ENST00000407587.2_Missense_Mutation_p.P1280L|MYO18B_ENST00000536101.1_Missense_Mutation_p.P1279L	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1279	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						CTGGACGCTCCACTCCTGAAG	0.567000													3	2					0	0	1	0	0
JAG1	182	broad.mit.edu	37	20	10622201	10622201	+	Silent	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr20:10622201G>C	ENST00000254958.5	-	23	3338	c.2823C>G	c.(2821-2823)ctC>ctG	p.L941L	JAG1_ENST00000423891.2_Silent_p.L782L	NM_000214.2	NP_000205.1	P78504	JAG1_HUMAN	jagged 1	941					angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|pancreas(1)|urinary_tract(1)	44						TCACCGGCTGGAGACTGGAAG	0.547000									Alagille Syndrome				22	61					0	0	1	0	0
TEX264	51368	broad.mit.edu	37	3	51737905	51737905	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:51737905C>G	ENST00000415259.1	+	5	1896	c.815C>G	c.(814-816)tCt>tGt	p.S272C	TEX264_ENST00000457573.1_Missense_Mutation_p.S272C|TEX264_ENST00000395057.1_Missense_Mutation_p.S272C|TEX264_ENST00000341333.5_Missense_Mutation_p.S272C|TEX264_ENST00000416589.1_Missense_Mutation_p.S272C|TEX264_ENST00000463857.1_3'UTR			Q9Y6I9	TX264_HUMAN	testis expressed 264	272						extracellular region				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)	7				BRCA - Breast invasive adenocarcinoma(193;8.53e-05)|Kidney(197;0.000594)|KIRC - Kidney renal clear cell carcinoma(197;0.000759)		AGCGGCTCCTCTTTTGAGGAG	0.667000													11	19					0	0	1	0	0
GABRB2	2561	broad.mit.edu	37	5	160972281	160972281	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr5:160972281C>T	ENST00000274547.2	-	4	406	c.189G>A	c.(187-189)ggG>ggA	p.G63G	GABRB2_ENST00000520240.1_Silent_p.G63G|GABRB2_ENST00000517547.1_5'UTR|GABRB2_ENST00000353437.6_Silent_p.G63G|GABRB2_ENST00000517901.1_5'UTR|GABRB2_ENST00000393959.1_Silent_p.G63G	NM_000813.2|NM_021911.2	NP_000804.1|NP_068711.1	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 2	63					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(9)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	26	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CAATGTTCATCCCCACAGCCA	0.453000													3	8					0	0	1	0	0
TTYH1	57348	broad.mit.edu	37	19	54942066	54942066	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr19:54942066C>T	ENST00000301194.4	+	9	1137	c.1015C>T	c.(1015-1017)Cag>Tag	p.Q339*	TTYH1_ENST00000391739.3_Missense_Mutation_p.S369L|TTYH1_ENST00000376530.3_Nonsense_Mutation_p.Q339*|AC008746.3_ENST00000457113.1_RNA|TTYH1_ENST00000489425.1_3'UTR|TTYH1_ENST00000376531.3_Nonsense_Mutation_p.Q339*			Q9H313	TTYH1_HUMAN	tweety family member 1	339					cell adhesion	chloride channel complex|plasma membrane	chloride channel activity|iron ion transmembrane transporter activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0767)		AGCTGTGCCTCAGTTCCCTTC	0.682000													8	22					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26432408	26432408	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr10:26432408G>A	ENST00000265944.5	+	21	2460	c.2294G>A	c.(2293-2295)aGa>aAa	p.R765K	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	765	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						GTGGATGCTAGAGTTATTGAA	0.318000													3	8					0	0	1	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21069131	21069131	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr12:21069131G>A	ENST00000381545.3	+	16	2278	c.2059G>A	c.(2059-2061)Gat>Aat	p.D687N	SLCO1B7_ENST00000554957.1_Intron|SLCO1B3_ENST00000261196.2_Missense_Mutation_p.D687N|LST3_ENST00000381541.3_Intron|SLCO1B3_ENST00000553473.1_Intron|LST3_ENST00000540229.1_Intron	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	687					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					TGCTGGAACAGATAGTAAAAC	0.348000													36	26					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38951118	38951118	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr19:38951118C>G	ENST00000355481.4	+	20	2595	c.2464C>G	c.(2464-2466)Ctt>Gtt	p.L822V	RYR1_ENST00000359596.3_Missense_Mutation_p.L822V|RYR1_ENST00000360985.3_Missense_Mutation_p.L822V	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	822					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GCGACTCCATCTTGAACCCAT	0.642000													29	68					0	0	1	0	0
C10orf90	118611	broad.mit.edu	37	10	128114450	128114450	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr10:128114450G>C	ENST00000284694.7	-	9	2203	c.2083C>G	c.(2083-2085)Caa>Gaa	p.Q695E	C10orf90_ENST00000544758.1_Missense_Mutation_p.Q792E|C10orf90_ENST00000480379.1_Missense_Mutation_p.Q99E|C10orf90_ENST00000356858.3_3'UTR|C10orf90_ENST00000454341.1_Missense_Mutation_p.Q598E	NM_001004298.2	NP_001004298.2	Q96M02	CJ090_HUMAN	chromosome 10 open reading frame 90	695										NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(19)|liver(1)|lung(29)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	65		all_epithelial(44;4.51e-05)|all_lung(145;0.0068)|Lung NSC(174;0.0105)|Colorectal(57;0.0848)|all_neural(114;0.0936)|Breast(234;0.203)		COAD - Colon adenocarcinoma(40;0.0442)|Colorectal(40;0.0479)		GCATTCCTTTGAAGGAGCTGG	0.488000													13	12					0	0	1	0	0
DMXL2	23312	broad.mit.edu	37	15	51772987	51772987	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr15:51772987C>G	ENST00000251076.5	-	24	6603	c.6316G>C	c.(6316-6318)Gag>Cag	p.E2106Q	DMXL2_ENST00000543779.2_Missense_Mutation_p.E2106Q|DMXL2_ENST00000449909.3_Missense_Mutation_p.E1470Q|RP11-707P17.1_ENST00000561007.1_RNA	NM_001174116.1|NM_015263.3	NP_001167587.1|NP_056078.2	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	2106						cell junction|synaptic vesicle membrane	Rab GTPase binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(26)|liver(1)|lung(28)|ovary(7)|prostate(7)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	101				all cancers(107;0.00494)		AGATCACTCTCTACTTTGGAA	0.383000													17	42					0	0	1	0	0
PKN3	29941	broad.mit.edu	37	9	131469234	131469234	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr9:131469234G>T	ENST00000291906.4	+	5	976	c.583G>T	c.(583-585)Gag>Tag	p.E195*		NM_013355.3	NP_037487.2	Q6P5Z2	PKN3_HUMAN	protein kinase N3	195					signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein binding|protein kinase C activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	24						AGCTGTGGCTGAGGGCGCCAA	0.647000													32	22					1.61788e-16	1.74789e-16	1	1	0
MICAL2	9645	broad.mit.edu	37	11	12264240	12264240	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr11:12264240A>G	ENST00000256194.4	+	20	2867	c.2579A>G	c.(2578-2580)aAc>aGc	p.N860S	MICAL2_ENST00000537344.1_Intron|MICAL2_ENST00000379612.3_Intron|MICAL2_ENST00000342902.5_Missense_Mutation_p.N860S|MICAL2_ENST00000527546.1_Intron	NM_001282663.1|NM_014632.2	NP_001269592.1|NP_055447.1	O94851	MICA2_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 2	860						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	47				Epithelial(150;0.00552)		AACTTGGCCAACAGGGAATTT	0.493000													18	56					0	0	1	0	0
SPOPL	339745	broad.mit.edu	37	2	139326581	139326581	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr2:139326581C>T	ENST00000280098.4	+	11	1489	c.1110C>T	c.(1108-1110)gcC>gcT	p.A370A		NM_001001664.2	NP_001001664.1	Q6IQ16	SPOPL_HUMAN	speckle-type POZ protein-like	370						nucleus				breast(2)|cervix(2)|endometrium(2)|large_intestine(2)|lung(11)|skin(2)	21				BRCA - Breast invasive adenocarcinoma(221;0.0296)		TAGCAGAAGCCTTTCGAGCAC	0.413000													53	192					0	0	1	0	0
TIMM8B	26521	broad.mit.edu	37	11	111957457	111957457	+	Silent	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr11:111957457C>G	ENST00000541231.1	-	1	65	c.36G>C	c.(34-36)ctG>ctC	p.L12L	TIMM8B_ENST00000504148.2_5'UTR			Q9Y5J9	TIM8B_HUMAN	translocase of inner mitochondrial membrane 8 homolog B (yeast)	0					protein import into mitochondrial inner membrane|sensory perception of sound|transmembrane transport	mitochondrial inner membrane presequence translocase complex|mitochondrial intermembrane space protein transporter complex	protein binding|zinc ion binding			large_intestine(1)	1		all_cancers(61;1.84e-10)|all_epithelial(67;9.33e-06)|Melanoma(852;4.01e-05)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0512)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)		Epithelial(105;6.01e-07)|BRCA - Breast invasive adenocarcinoma(274;6.17e-07)|all cancers(92;1.03e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0512)		TTGTTCGCCTCAGGCTCGCCA	0.632000											OREG0021332	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	5					0	0	1	0	0
PALB2	79728	broad.mit.edu	37	16	23641235	23641235	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr16:23641235G>C	ENST00000261584.4	-	5	2392	c.2240C>G	c.(2239-2241)tCt>tGt	p.S747C		NM_024675.3	NP_078951.2	Q86YC2	PALB2_HUMAN	partner and localizer of BRCA2	747					double-strand break repair via homologous recombination	nucleoplasm	DNA binding|protein binding			breast(5)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(21)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(3)	55				GBM - Glioblastoma multiforme(48;0.0167)		AACTTCTGTAGATGCTTTTTC	0.473000			"""F, N, Mis"""			"""Wilms tumor, medulloblastoma, AML ,breast"""		Involved in tolerance or repair of DNA crosslinks					11	51					0	0	1	0	0
AMBRA1	55626	broad.mit.edu	37	11	46419135	46419135	+	Silent	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr11:46419135G>C	ENST00000458649.2	-	18	4180	c.3762C>G	c.(3760-3762)gtC>gtG	p.V1254V	AMBRA1_ENST00000528950.1_Silent_p.V1225V|AMBRA1_ENST00000298834.3_Silent_p.V1194V|AMBRA1_ENST00000534300.1_Silent_p.V1194V|AMBRA1_ENST00000314845.3_Silent_p.V1164V|AMBRA1_ENST00000533727.1_Silent_p.V1135V|AMBRA1_ENST00000426438.1_Silent_p.V1225V			Q9C0C7	AMRA1_HUMAN	autophagy/beclin-1 regulator 1	1254					autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				NS(1)|breast(3)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	39				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)		CAGGAATGGGGACAGGGGAGG	0.647000													8	22					0	0	1	0	0
USP10	9100	broad.mit.edu	37	16	84778970	84778970	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr16:84778970G>A	ENST00000219473.7	+	4	996	c.883G>A	c.(883-885)Gag>Aag	p.E295K	USP10_ENST00000570191.1_Missense_Mutation_p.E299K	NM_001272075.1|NM_005153.2	NP_001259004.1|NP_005144.2	Q14694	UBP10_HUMAN	ubiquitin specific peptidase 10	295					DNA damage response, signal transduction by p53 class mediator|DNA repair|protein deubiquitination|ubiquitin-dependent protein catabolic process	early endosome|intermediate filament cytoskeleton|nucleus	cystic fibrosis transmembrane conductance regulator binding|p53 binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			endometrium(3)|kidney(1)|large_intestine(7)|lung(3)|prostate(1)|stomach(1)|urinary_tract(1)	17						ATCCTCGGGTGAGGGCACAGC	0.557000													13	20					0	0	1	0	0
PKM	5315	broad.mit.edu	37	15	72495379	72495379	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr15:72495379G>C	ENST00000319622.6	-	9	1747	c.1291C>G	c.(1291-1293)Ctg>Gtg	p.L431V	PKM_ENST00000389093.3_Missense_Mutation_p.L431V|PKM_ENST00000449901.2_Intron|PKM_ENST00000565184.1_Missense_Mutation_p.L431V|PKM_ENST00000565154.1_Missense_Mutation_p.L431V|PKM_ENST00000335181.5_Intron|PKM_ENST00000568459.1_Missense_Mutation_p.L431V|PKM_ENST00000568883.1_Missense_Mutation_p.L266V	NM_001206796.1|NM_182470.2|NM_182471.2	NP_001193725.1|NP_872270.1|NP_872271.1			pyruvate kinase, muscle											endometrium(1)|lung(7)	8						GACTCCGTCAGAACTATCAAA	0.547000													10	50					0	0	1	0	0
ITGAV	3685	broad.mit.edu	37	2	187506202	187506202	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr2:187506202T>A	ENST00000261023.3	+	12	1320	c.1046T>A	c.(1045-1047)cTa>cAa	p.L349Q	ITGAV_ENST00000374907.3_Missense_Mutation_p.L313Q|ITGAV_ENST00000433736.2_Missense_Mutation_p.L303Q|AC017101.10_ENST00000453665.1_RNA	NM_002210.3	NP_002201	P06756	ITAV_HUMAN	integrin, alpha V	349					angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		TCAGTGTCTCTACAGAGAGCT	0.498000													45	100					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78335677	78335677	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr17:78335677G>T	ENST00000582970.1	+	39	11487	c.11344G>T	c.(11344-11346)Gag>Tag	p.E3782*	CTD-2047H16.4_ENST00000572151.1_RNA|CTD-2047H16.4_ENST00000575034.1_RNA|RNF213_ENST00000336301.6_Nonsense_Mutation_p.E1855*|RNF213_ENST00000508628.2_Nonsense_Mutation_p.E3831*	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			GTCAACGGAGGAGGAATTAAA	0.507000													7	27					5.4927e-09	5.84279e-09	1	1	0
CETN3	1070	broad.mit.edu	37	5	89695298	89695298	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr5:89695298C>A	ENST00000283122.3	-	4	461	c.337G>T	c.(337-339)Gat>Tat	p.D113Y	CETN3_ENST00000522864.1_Missense_Mutation_p.D113Y|CETN3_ENST00000522565.1_Missense_Mutation_p.D113Y|CETN3_ENST00000522083.1_Missense_Mutation_p.D113Y	NM_004365.2	NP_004356.2	O15182	CETN3_HUMAN	centrin, EF-hand protein, 3	113	EF-hand 3.				cell division|centrosome cycle|mitosis	centriole	calcium ion binding			lung(3)	3		all_cancers(142;7.93e-09)|all_epithelial(76;2.13e-11)|Lung NSC(167;2.46e-05)|all_lung(232;3.25e-05)|Ovarian(174;0.00832)|Colorectal(57;0.122)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(54;1.42e-32)|Epithelial(54;1.45e-26)|all cancers(79;2.87e-23)		CCTGAATCATCATCATCAAAT	0.328000													9	25					0.000673444	0.000687652	1	1	0
RECK	8434	broad.mit.edu	37	9	36100521	36100521	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr9:36100521C>G	ENST00000377966.3	+	11	1845	c.1279C>G	c.(1279-1281)Cgg>Ggg	p.R427G		NM_021111.2	NP_066934.1	O95980	RECK_HUMAN	reversion-inducing-cysteine-rich protein with kazal motifs	427						anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	32			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)			TAGTAAATCTCGGGGAAGTAT	0.388000													14	21					0	0	1	0	0
FLII	2314	broad.mit.edu	37	17	18150540	18150540	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr17:18150540C>A	ENST00000327031.4	-	21	2844	c.2619G>T	c.(2617-2619)atG>atT	p.M873I	FLII_ENST00000379450.4_Missense_Mutation_p.M787I|FLII_ENST00000578558.1_Intron|FLII_ENST00000579294.1_Missense_Mutation_p.M862I|FLII_ENST00000545457.2_Missense_Mutation_p.M818I	NM_002018.3	NP_002009.1	Q13045	FLII_HUMAN	flightless I homolog (Drosophila)	873					multicellular organismal development|muscle contraction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	actin binding			central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32	all_neural(463;0.228)					GGTCAGCCTTCATCTGGTCTT	0.692000													18	34					5.35267e-07	5.59544e-07	1	1	0
NDRG2	57447	broad.mit.edu	37	14	21490649	21490649	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr14:21490649G>C	ENST00000556147.1	-	4	1065	c.125C>G	c.(124-126)tCt>tGt	p.S42C	NDRG2_ENST00000397855.3_Missense_Mutation_p.S28C|NDRG2_ENST00000298687.5_Missense_Mutation_p.S42C|NDRG2_ENST00000554143.1_Missense_Mutation_p.S28C|NDRG2_ENST00000397844.2_Missense_Mutation_p.S28C|NDRG2_ENST00000360463.3_Missense_Mutation_p.S28C|NDRG2_ENST00000298684.5_Missense_Mutation_p.S28C|NDRG2_ENST00000397853.3_Missense_Mutation_p.S42C|NDRG2_ENST00000553503.1_Missense_Mutation_p.S28C|NDRG2_ENST00000554104.1_5'UTR|NDRG2_ENST00000397851.2_Missense_Mutation_p.S42C|NDRG2_ENST00000397856.3_Missense_Mutation_p.S28C|NDRG2_ENST00000397847.2_Missense_Mutation_p.S42C|NDRG2_ENST00000555158.1_Missense_Mutation_p.S28C|NDRG2_ENST00000403829.3_Missense_Mutation_p.S38C|NDRG2_ENST00000397858.1_Missense_Mutation_p.S42C|NDRG2_ENST00000350792.3_Missense_Mutation_p.S28C			Q9UN36	NDRG2_HUMAN	NDRG family member 2	42					cell differentiation|nervous system development	centrosome|cytosol|Golgi apparatus|nucleus|perinuclear region of cytoplasm				breast(2)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	23	all_cancers(95;0.00185)		OV - Ovarian serous cystadenocarcinoma(11;6.85e-11)|Epithelial(56;9.49e-09)|all cancers(55;3.84e-08)	GBM - Glioblastoma multiforme(265;0.0191)		TGTCTCCACAGAGTGAGTCTG	0.567000													7	14					0	0	1	0	0
PALB2	79728	broad.mit.edu	37	16	23641730	23641730	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr16:23641730G>T	ENST00000261584.4	-	5	1897	c.1745C>A	c.(1744-1746)tCc>tAc	p.S582Y		NM_024675.3	NP_078951.2	Q86YC2	PALB2_HUMAN	partner and localizer of BRCA2	582					double-strand break repair via homologous recombination	nucleoplasm	DNA binding|protein binding			breast(5)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(21)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(3)	55				GBM - Glioblastoma multiforme(48;0.0167)		ATCATCCAAGGATAAATAAGC	0.368000			"""F, N, Mis"""			"""Wilms tumor, medulloblastoma, AML ,breast"""		Involved in tolerance or repair of DNA crosslinks					4	15					0.150653	0.150965	1	1	0
SGPP2	130367	broad.mit.edu	37	2	223339376	223339376	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr2:223339376C>G	ENST00000321276.7	+	2	395	c.309C>G	c.(307-309)atC>atG	p.I103M		NM_152386.2	NP_689599.2	Q8IWX5	SGPP2_HUMAN	sphingosine-1-phosphate phosphatase 2	103					sphingosine metabolic process	endoplasmic reticulum membrane|integral to membrane	dihydrosphingosine-1-phosphate phosphatase activity|sphingosine-1-phosphate phosphatase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|skin(1)|stomach(1)|urinary_tract(2)	18		Renal(207;0.0376)		Epithelial(121;2.08e-09)|all cancers(144;9.25e-07)|LUSC - Lung squamous cell carcinoma(224;0.011)|Lung(261;0.0143)		TGTTCTACATCACGTTTCTTC	0.353000													7	30					0	0	1	0	0
PLEKHG6	55200	broad.mit.edu	37	12	6435720	6435720	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr12:6435720C>T	ENST00000449001.2	+	13	2049	c.1555C>T	c.(1555-1557)Cag>Tag	p.Q519*	PLEKHG6_ENST00000304581.8_Nonsense_Mutation_p.Q81*|PLEKHG6_ENST00000011684.7_Nonsense_Mutation_p.Q551*|PLEKHG6_ENST00000396988.3_Nonsense_Mutation_p.Q551*	NM_001144857.1	NP_001138329.1	Q3KR16	PKHG6_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 6	551					regulation of Rho protein signal transduction	cleavage furrow|cytoplasm|spindle pole	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(4)	23						GGAGGGCTCTCAGAGCAGCGC	0.597000													8	7					0	0	1	0	0
LSG1	55341	broad.mit.edu	37	3	194392810	194392810	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:194392810G>C	ENST00000265245.5	-	1	396	c.82C>G	c.(82-84)Cgt>Ggt	p.R28G	LSG1_ENST00000480853.1_Intron	NM_018385.2	NP_060855.2	Q9H089	LSG1_HUMAN	large 60S subunit nuclear export GTPase 1	28					nuclear export|protein transport	Cajal body|endoplasmic reticulum	GTP binding|hydrolase activity			breast(2)|endometrium(3)|large_intestine(2)|lung(9)	16	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;7.55e-06)		TCAGTGTGACGATGGCTTCGG	0.567000													15	34					0	0	1	0	0
HTT	3064	broad.mit.edu	37	4	3131758	3131758	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr4:3131758C>T	ENST00000355072.5	+	13	1996	c.1851C>T	c.(1849-1851)ttC>ttT	p.F617F		NM_002111.6	NP_002102	P42858	HD_HUMAN	huntingtin	617					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		CGGAGGCCTTCAGGAACTCTT	0.478000													12	44					0	0	1	0	0
PLA2R1	22925	broad.mit.edu	37	2	160806179	160806179	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr2:160806179G>A	ENST00000283243.7	-	25	3855	c.3649C>T	c.(3649-3651)Cgc>Tgc	p.R1217C	PLA2R1_ENST00000392771.1_Missense_Mutation_p.R1217C	NM_001195641.1|NM_007366.4	NP_001182570.1|NP_031392.3	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1, 180kDa	1217	C-type lectin 7.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding		PLA2R1/RBMS1(2)	central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(17)|lung(20)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	60						CTATGCCAGCGTCCGTTGCTG	0.448000													12	42					0	0	1	0	0
ATP12A	479	broad.mit.edu	37	13	25284984	25284984	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr13:25284984C>T	ENST00000218548.6	+	21	3303	c.2970C>T	c.(2968-2970)ctC>ctT	p.L990L	ATP12A_ENST00000381946.3_Silent_p.L984L	NM_001185085.1|NM_001676.5	NP_001172014.1|NP_001667.4	P54707	AT12A_HUMAN	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	984					ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			breast(6)|central_nervous_system(4)|endometrium(3)|kidney(5)|large_intestine(23)|lung(23)|ovary(2)|pancreas(1)|prostate(2)|skin(5)	74		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	GTCTGATCCTCTCCTATGGCC	0.498000													4	33					0	0	1	0	0
EPHA2	1969	broad.mit.edu	37	1	16459753	16459753	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr1:16459753C>T	ENST00000358432.5	-	11	2129	c.1975G>A	c.(1975-1977)Gac>Aac	p.D659N		NM_004431.3	NP_004422.2	P29317	EPHA2_HUMAN	EPH receptor A2	659	Mediates interaction with ARHGEF16 and ELMO2.|Protein kinase.				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	42		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	CCGAGGAAGTCCACTCGCTGC	0.607000													18	41					0	0	1	0	0
KIF18A	81930	broad.mit.edu	37	11	28098656	28098656	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr11:28098656C>T	ENST00000263181.6	-	10	1613	c.1323G>A	c.(1321-1323)ctG>ctA	p.L441L		NM_031217.3	NP_112494.3	Q8NI77	KI18A_HUMAN	kinesin family member 18A	441					blood coagulation|microtubule depolymerization|microtubule-based movement|mitotic metaphase plate congression|mitotic prometaphase|protein transport	caveola|cytosol|kinetochore microtubule|microtubule organizing center|nucleus|ruffle	actin binding|ATP binding|microtubule plus-end binding|plus-end-directed microtubule motor activity|tubulin-dependent ATPase activity|ubiquitin binding			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(10)|ovary(3)|prostate(1)|skin(1)|urinary_tract(2)	36						TTTCCAACTTCAGATATTCTT	0.303000													13	18					0	0	1	0	0
ABHD16A	7920	broad.mit.edu	37	6	31655876	31655876	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr6:31655876G>C	ENST00000375842.4	-	16	1641	c.655C>G	c.(655-657)Cct>Gct	p.P219A	ABHD16A_ENST00000395952.3_Missense_Mutation_p.P438A|XXbac-BPG32J3.20_ENST00000461287.1_3'UTR|ABHD16A_ENST00000440843.2_Missense_Mutation_p.P405A|ABHD16A_ENST00000471644.1_5'UTR			O95870	ABHGA_HUMAN	abhydrolase domain containing 16A	438						integral to membrane	hydrolase activity|protein binding			endometrium(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)	10						ATGTCCTCAGGAACCCTGGGG	0.587000													23	62					0	0	1	0	0
KIF2C	11004	broad.mit.edu	37	1	45223597	45223597	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr1:45223597C>T	ENST00000372217.1	+	11	1275	c.924C>T	c.(922-924)ctC>ctT	p.L308L	KIF2C_ENST00000372222.3_Silent_p.L249L|KIF2C_ENST00000372224.4_Silent_p.L362L|KIF2C_ENST00000493027.1_3'UTR|KIF2C_ENST00000372218.4_Silent_p.L321L			Q99661	KIF2C_HUMAN	kinesin family member 2C	362	Kinesin-motor.				blood coagulation|cell division|cell proliferation|chromosome segregation|establishment or maintenance of microtubule cytoskeleton polarity|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|kinesin complex|microtubule|nucleus	ATP binding|centromeric DNA binding|microtubule motor activity|microtubule plus-end binding			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(16)|ovary(1)|skin(1)|urinary_tract(1)	34	Acute lymphoblastic leukemia(166;0.155)					GCGGAGACCTCTCTGGGAAAG	0.537000													25	57					0	0	1	0	0
TET1	80312	broad.mit.edu	37	10	70405861	70405861	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr10:70405861G>C	ENST00000373644.4	+	4	3584	c.3375G>C	c.(3373-3375)caG>caC	p.Q1125H		NM_030625.2	NP_085128.2	Q8NFU7	TET1_HUMAN	tet methylcytosine dioxygenase 1	1125					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(2)|ovary(5)|prostate(1)|upper_aerodigestive_tract(2)	21						CAATACAACAGAAACCACCTT	0.378000													3	14					0	0	1	0	0
PROSER1	80209	broad.mit.edu	37	13	39587987	39587987	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr13:39587987G>C	ENST00000352251.3	-	11	2235	c.1402C>G	c.(1402-1404)Ctt>Gtt	p.L468V	PROSER1_ENST00000350125.3_Missense_Mutation_p.L446V|PROSER1_ENST00000484434.3_Intron	NM_025138.4	NP_079414.3	Q86XN7	CM023_HUMAN	proline and serine rich 1	468	Ser-rich.																GCAGACAAAAGAGGACTGTTC	0.498000													17	43					0	0	1	0	0
HK2	3099	broad.mit.edu	37	2	75115036	75115036	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr2:75115036G>T	ENST00000290573.2	+	16	2826	c.2226G>T	c.(2224-2226)gaG>gaT	p.E742D	HK2_ENST00000409174.1_Missense_Mutation_p.E714D	NM_000189.4	NP_000180.2	P52789	HXK2_HUMAN	hexokinase 2	742	Catalytic.|Substrate 2 binding.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(22)|ovary(2)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	43						GCAGGTTCGAGAAAATGATCA	0.507000													16	46					4.96729e-08	5.22645e-08	1	1	0
ABHD16A	7920	broad.mit.edu	37	6	31657389	31657389	+	Silent	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr6:31657389G>A	ENST00000375842.4	-	12	1379	c.393C>T	c.(391-393)atC>atT	p.I131I	ABHD16A_ENST00000395952.3_Silent_p.I350I|XXbac-BPG32J3.20_ENST00000461287.1_3'UTR|ABHD16A_ENST00000440843.2_Silent_p.I317I|ABHD16A_ENST00000471644.1_5'UTR			O95870	ABHGA_HUMAN	abhydrolase domain containing 16A	350						integral to membrane	hydrolase activity|protein binding			endometrium(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)	10						AGGCGTAGATGATGATGTCCT	0.612000													3	8					0	0	1	0	0
RTL1	388015	broad.mit.edu	37	14	101349355	101349355	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr14:101349355C>T	ENST00000534062.1	-	1	1829	c.1771G>A	c.(1771-1773)Gag>Aag	p.E591K	MIR127_ENST00000384876.1_RNA	NM_001134888.2	NP_001128360.1	E9PKS8	E9PKS8_HUMAN	retrotransposon-like 1	591										breast(1)|endometrium(5)|kidney(4)|large_intestine(1)|lung(5)|pancreas(1)|prostate(2)|skin(2)	21						TCAGAGGGCTCTGATTCAGAA	0.562000													12	27					0	0	1	0	0
ABHD16A	7920	broad.mit.edu	37	6	31657895	31657895	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr6:31657895G>T	ENST00000375842.4	-	11	1246	c.260C>A	c.(259-261)tCa>tAa	p.S87*	ABHD16A_ENST00000395952.3_Nonsense_Mutation_p.S306*|XXbac-BPG32J3.20_ENST00000461287.1_3'UTR|ABHD16A_ENST00000440843.2_Nonsense_Mutation_p.S273*|ABHD16A_ENST00000471644.1_5'UTR			O95870	ABHGA_HUMAN	abhydrolase domain containing 16A	306						integral to membrane	hydrolase activity|protein binding			endometrium(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)	10						GCCCAGGACTGAATATCCAGC	0.552000													10	21					0.000442599	0.000453852	1	1	0
CCDC130	81576	broad.mit.edu	37	19	13873643	13873643	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr19:13873643G>A	ENST00000586600.1	+	11	1455	c.952G>A	c.(952-954)Gaa>Aaa	p.E318K	CCDC130_ENST00000221554.8_Missense_Mutation_p.E318K|CCDC130_ENST00000587019.1_3'UTR			P13994	CC130_HUMAN	coiled-coil domain containing 130	318					response to virus		protein binding			endometrium(2)|kidney(1)|large_intestine(3)|ovary(1)|skin(2)|urinary_tract(1)	10			OV - Ovarian serous cystadenocarcinoma(19;6.02e-23)|Epithelial(5;2.58e-18)			CAAGTCTGGGGAACCGCGGGT	0.706000													7	8					0	0	1	0	0
NCOA3	8202	broad.mit.edu	37	20	46264448	46264448	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr20:46264448C>G	ENST00000372004.3	+	11	1711	c.1495C>G	c.(1495-1497)Cct>Gct	p.P499A	NCOA3_ENST00000371998.3_Missense_Mutation_p.P499A|NCOA3_ENST00000371997.3_Missense_Mutation_p.P509A|NCOA3_ENST00000341724.6_Missense_Mutation_p.P509A	NM_001174087.1|NM_001174088.1|NM_006534.3|NM_181659.2	NP_001167558.1|NP_001167559.1|NP_006525.2|NP_858045.1	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3	499					androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			breast(3)|endometrium(3)|kidney(4)|large_intestine(12)|lung(19)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						TCAGTTTTCTCCTGTTGCAGG	0.368000													11	35					0	0	1	0	0
TUBG1	7283	broad.mit.edu	37	17	40766015	40766015	+	Splice_Site	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr17:40766015C>T	ENST00000251413.3	+	8	904	c.842C>T	c.(841-843)tCa>tTa	p.S281L		NM_001070.4	NP_001061.2	P23258	TBG1_HUMAN	tubulin, gamma 1	281					G2/M transition of mitotic cell cycle|meiotic spindle organization|protein polymerization	condensed nuclear chromosome|cytosol|gamma-tubulin complex|polar microtubule	GTP binding|GTPase activity|protein binding|structural constituent of cytoskeleton			endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)	12		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.129)		ACGGACCAGTCAGTAAGAGCA	0.612000													40	115					0	0	1	0	0
RIPK1	8737	broad.mit.edu	37	6	3113468	3113468	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr6:3113468G>A	ENST00000259808.4	+	11	2209	c.1911G>A	c.(1909-1911)atG>atA	p.M637I	RIPK1_ENST00000541791.1_Missense_Mutation_p.M591I|RIPK1_ENST00000380409.2_Missense_Mutation_p.M637I			Q13546	RIPK1_HUMAN	receptor (TNFRSF)-interacting serine-threonine kinase 1	637	Death.				activation of caspase activity|activation of JUN kinase activity|activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|induction of necroptosis by extracellular signals|innate immune response|MyD88-independent toll-like receptor signaling pathway|positive regulation of anti-apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|protein autophosphorylation|regulation of ATP:ADP antiporter activity|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|death-inducing signaling complex|endosome membrane|mitochondrion|receptor complex	ATP binding|death domain binding|death receptor binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	23	Ovarian(93;0.0386)	all_hematologic(90;0.0895)				AGTGGGTGATGAGGGAAGGCA	0.512000													10	19					0	0	1	0	0
CEACAM4	1089	broad.mit.edu	37	19	42132106	42132106	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr19:42132106C>T	ENST00000221954.2	-	2	403	c.293G>A	c.(292-294)cGa>cAa	p.R98Q	CEACAM4_ENST00000600925.1_Missense_Mutation_p.R98Q	NM_001817.2	NP_001808.2	O75871	CEAM4_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 4	98	Ig-like V-type.					integral to plasma membrane|membrane fraction				NS(1)|endometrium(1)|large_intestine(3)|lung(4)|prostate(3)|skin(3)|urinary_tract(1)	16						TACTGTCTCTCGACCACTGTA	0.493000													28	82					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	134034346	134034346	+	Silent	SNP	C	C	T	rs140927008		TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr8:134034346C>T	ENST00000220616.4	+	40	7027	c.6987C>T	c.(6985-6987)atC>atT	p.I2329I	TG_ENST00000377869.1_Silent_p.I2272I|TG_ENST00000519543.1_Silent_p.I462I|TG_ENST00000542445.1_Silent_p.I699I	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	2329					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity	p.I2329I(1)		NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GCAACCTCATCGTGGTCACTG	0.597000													19	138					0	0	1	0	0
LAMA4	3910	broad.mit.edu	37	6	112493992	112493992	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr6:112493992C>T	ENST00000230538.7	-	12	1769	c.1372G>A	c.(1372-1374)Gag>Aag	p.E458K	LAMA4_ENST00000389463.4_Missense_Mutation_p.E451K|LAMA4_ENST00000522006.1_Missense_Mutation_p.E451K|LAMA4_ENST00000424408.2_Missense_Mutation_p.E451K	NM_001105206.2	NP_001098676.2	Q16363	LAMA4_HUMAN	laminin, alpha 4	458	Domain II and I.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			NS(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(42)|ovary(4)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(8)	100		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		TGCCAGCTCTCAGCCTGGCTC	0.512000													3	20					0	0	1	0	0
RHOT2	89941	broad.mit.edu	37	16	721202	721202	+	Splice_Site	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr16:721202C>T	ENST00000315082.4	+	11	982	c.868C>T	c.(868-870)Ctg>Ttg	p.L290L		NM_138769.2	NP_620124.1	Q8IXI1	MIRO2_HUMAN	ras homolog family member T2	290					apoptosis|cellular homeostasis|mitochondrion transport along microtubule|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to mitochondrial outer membrane|plasma membrane	calcium ion binding|GTP binding|GTPase activity|protein binding			endometrium(2)|kidney(3)|lung(4)|ovary(1)|pancreas(2)|prostate(1)	13		Hepatocellular(780;0.0218)				TCTCTCCCCTCTGTGAGTGAT	0.652000													21	59					0	0	1	0	0
CELSR2	1952	broad.mit.edu	37	1	109812122	109812122	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr1:109812122G>T	ENST00000271332.3	+	21	6950	c.6889G>T	c.(6889-6891)Gcc>Tcc	p.A2297S		NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	2297					dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		TCTGCCCCGGGCCCTGGACAA	0.597000													12	34					6.40141e-05	6.62026e-05	1	1	0
RNF17	56163	broad.mit.edu	37	13	25399909	25399909	+	Splice_Site	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr13:25399909C>T	ENST00000255324.5	+	16	2296	c.2244C>T	c.(2242-2244)atC>atT	p.I748I	RNF17_ENST00000381921.1_Splice_Site_p.I748I	NM_001184993.1|NM_031277.2	NP_001171922.1|NP_112567.2	Q9BXT8	RNF17_HUMAN	ring finger protein 17	748	Tudor 1.				multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(3)|skin(6)	36		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		CAAAAGTTATCGGTAGGAGAA	0.368000													18	44					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32635568	32635568	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr9:32635568C>T	ENST00000242310.4	-	1	99	c.10G>A	c.(10-12)Ggc>Agc	p.G4S	RP11-555J4.4_ENST00000430787.1_RNA	NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	4					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		AAATCGCAGCCGGGTCGCATA	0.547000													39	20					0	0	1	0	0
ABCF3	55324	broad.mit.edu	37	3	183905743	183905743	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:183905743G>C	ENST00000429586.2	+	6	726	c.541G>C	c.(541-543)Gag>Cag	p.E181Q	ABCF3_ENST00000292808.5_Missense_Mutation_p.E175Q|EIF2B5_ENST00000444495.1_Intron	NM_018358.2	NP_060828.2	Q9NUQ8	ABCF3_HUMAN	ATP-binding cassette, sub-family F (GCN20), member 3	181	ABC transporter 1.						ATP binding|ATPase activity	p.E181Q(1)		breast(2)|cervix(1)|endometrium(2)|large_intestine(5)|lung(20)|ovary(3)|prostate(5)|upper_aerodigestive_tract(1)	39	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.35e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TGTGCGAATTGAGAACTTTGA	0.463000													24	88					0	0	1	0	0
ELANE	1991	broad.mit.edu	37	19	852912	852912	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr19:852912G>C	ENST00000590230.1	+	3	245	c.104G>C	c.(103-105)cGa>cCa	p.R35P	ELANE_ENST00000263621.1_Missense_Mutation_p.R35P			P08246	ELNE_HUMAN	elastase, neutrophil expressed	35	Peptidase S1.				cellular calcium ion homeostasis|negative regulation of chemokine biosynthetic process|negative regulation of chemotaxis|negative regulation of inflammatory response|negative regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of MAP kinase activity|positive regulation of smooth muscle cell proliferation|protein catabolic process|proteolysis|response to UV	cell surface|extracellular region|stored secretory granule	bacterial cell surface binding|cytokine binding|heparin binding			breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(1)|lung(4)|pancreas(1)	13					Alpha-1-proteinase inhibitor(DB00058)|Filgrastim(DB00099)|Pegfilgrastim(DB00019)	GGGGGCCGGCGAGCGCGGCCC	0.726000													6	20					0	0	1	0	0
C2orf71	388939	broad.mit.edu	37	2	29294896	29294896	+	Silent	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr2:29294896C>G	ENST00000331664.5	-	1	2231	c.2232G>C	c.(2230-2232)ctG>ctC	p.L744L		NM_001029883.2	NP_001025054.1	A6NGG8	CB071_HUMAN	chromosome 2 open reading frame 71	744					response to stimulus|visual perception	photoreceptor outer segment				NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						CCAGCATCCTCAGACTCTCCG	0.552000													13	32					0	0	1	0	0
RHBDF1	64285	broad.mit.edu	37	16	113018	113018	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr16:113018C>G	ENST00000262316.6	-	5	767	c.625G>C	c.(625-627)Gag>Cag	p.E209Q	RHBDF1_ENST00000454039.2_Missense_Mutation_p.E209Q	NM_022450.3	NP_071895.3	Q96CC6	RHDF1_HUMAN	rhomboid 5 homolog 1 (Drosophila)	209					cell migration|cell proliferation|negative regulation of protein secretion|protein transport|proteolysis|regulation of epidermal growth factor receptor signaling pathway|regulation of proteasomal protein catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	18		all_cancers(16;2.56e-05)|all_epithelial(16;0.000116)|Hepatocellular(780;0.0068)|Lung NSC(18;0.0795)|all_lung(18;0.159)				GCCACCGACTCTCGCTTGCGC	0.706000													13	25					0	0	1	0	0
ABHD16A	7920	broad.mit.edu	37	6	31655465	31655465	+	Silent	SNP	G	G	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr6:31655465G>T	ENST00000375842.4	-	18	1829	c.843C>A	c.(841-843)ctC>ctA	p.L281L	ABHD16A_ENST00000395952.3_Silent_p.L500L|XXbac-BPG32J3.20_ENST00000461287.1_3'UTR|ABHD16A_ENST00000440843.2_Silent_p.L467L|ABHD16A_ENST00000471644.1_5'UTR			O95870	ABHGA_HUMAN	abhydrolase domain containing 16A	500						integral to membrane	hydrolase activity|protein binding			endometrium(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)	10						GGTAGGAGCGGAGGACAGACA	0.607000													6	30					0.0215528	0.0217777	1	1	0
AIM1	202	broad.mit.edu	37	6	106967276	106967276	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr6:106967276G>C	ENST00000369066.3	+	2	1456	c.969G>C	c.(967-969)aaG>aaC	p.K323N		NM_001624.2	NP_001615	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	323							sugar binding			breast(8)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(7)|large_intestine(13)|lung(20)|ovary(5)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	69	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		AACCTGAAAAGAAAGTAATGC	0.443000													14	31					0	0	1	0	0
SEC63	11231	broad.mit.edu	37	6	108279136	108279136	+	Silent	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr6:108279136G>A	ENST00000369002.4	-	1	257	c.78C>T	c.(76-78)atC>atT	p.I26I	SEC63_ENST00000460009.1_5'UTR|RP1-191J18.66_ENST00000606070.1_RNA	NM_007214.4	NP_009145.1	Q9UGP8	SEC63_HUMAN	SEC63 homolog (S. cerevisiae)	26					protein folding|protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|receptor activity|unfolded protein binding			endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		all_cancers(87;5.35e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00225)|Colorectal(196;0.0294)		BRCA - Breast invasive adenocarcinoma(108;0.0079)|Epithelial(106;0.0356)|all cancers(137;0.0525)|OV - Ovarian serous cystadenocarcinoma(136;0.054)		CCGGGATCACGATGAGCCCCA	0.667000													14	41					0	0	1	0	0
IRX5	10265	broad.mit.edu	37	16	54966809	54966809	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr16:54966809G>A	ENST00000394636.4	+	2	986	c.649G>A	c.(649-651)Gaa>Aaa	p.E217K	IRX5_ENST00000558597.1_Missense_Mutation_p.E151K|IRX5_ENST00000560154.1_Intron|IRX5_ENST00000320990.5_Missense_Mutation_p.E217K			P78411	IRX5_HUMAN	iroquois homeobox 5	217					response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|vitamin D binding			kidney(3)|large_intestine(6)|lung(4)|prostate(1)	14						CGAGGGCCCCGAAGCAGGTTG	0.652000													55	109					0	0	1	0	0
SLC2A7	155184	broad.mit.edu	37	1	9078298	9078298	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr1:9078298G>C	ENST00000400906.1	-	5	572	c.573C>G	c.(571-573)atC>atG	p.I191M		NM_207420.2	NP_997303.2	Q6PXP3	GTR7_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 7	191						integral to membrane|plasma membrane	sugar transmembrane transporter activity			NS(1)|breast(1)|endometrium(4)|large_intestine(10)|lung(4)|prostate(2)|skin(2)	24	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.04e-07)|COAD - Colon adenocarcinoma(227;7.66e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00177)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|READ - Rectum adenocarcinoma(331;0.0642)		GGTTGCCCAAGATGGCCTGGA	0.577000													14	33					0	0	1	0	0
PITX3	5309	broad.mit.edu	37	10	103991486	103991486	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr10:103991486C>G	ENST00000370002.3	-	3	333	c.180G>C	c.(178-180)aaG>aaC	p.K60N	PITX3_ENST00000539804.1_Missense_Mutation_p.K60N	NM_005029.3	NP_005020.1	O75364	PITX3_HUMAN	paired-like homeodomain 3	60					dopaminergic neuron differentiation|lens morphogenesis in camera-type eye|midbrain development|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(2)|lung(2)	5		Colorectal(252;0.00957)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		GCCGCTGCTTCTTTTTCAGCG	0.667000													8	2					0	0	1	0	0
SSH2	85464	broad.mit.edu	37	17	27959822	27959822	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr17:27959822C>G	ENST00000269033.3	-	15	2460	c.2309G>C	c.(2308-2310)gGa>gCa	p.G770A	RP11-68I3.2_ENST00000581474.1_RNA|SSH2_ENST00000540801.1_Missense_Mutation_p.G797A	NM_001282129.1|NM_033389.2	NP_001269058.1|NP_203747.2	Q76I76	SSH2_HUMAN	slingshot protein phosphatase 2	770					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity		SSH2/SUZ12(2)	breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						TAAGATGTCTCCTTTCAGTTG	0.453000													8	15					0	0	1	0	0
PTPRO	5800	broad.mit.edu	37	12	15636938	15636938	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr12:15636938G>A	ENST00000281171.4	+	2	436	c.106G>A	c.(106-108)Gat>Aat	p.D36N	PTPRO_ENST00000348962.2_Missense_Mutation_p.D36N|PTPRO_ENST00000543886.1_Missense_Mutation_p.D36N	NM_030667.2	NP_109592.1	Q16827	PTPRO_HUMAN	protein tyrosine phosphatase, receptor type, O	36						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(2)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(11)|lung(30)|ovary(2)|prostate(1)|skin(17)|upper_aerodigestive_tract(1)	74		Hepatocellular(102;0.244)				AACTGTCCAAGATGATAATAA	0.343000													11	16					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151878254	151878254	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr7:151878254C>G	ENST00000355193.2	-	36	6909	c.6691G>C	c.(6691-6693)Gag>Cag	p.E2231Q	KMT2C_ENST00000262189.6_Missense_Mutation_p.E2231Q					lysine (K)-specific methyltransferase 2C																		GTAAAACCCTCTGAAATCCTT	0.507000													8	31					0	0	1	0	0
KRAS	3845	broad.mit.edu	37	12	25380275	25380275	+	Missense_Mutation	SNP	T	T	A	rs17851045		TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr12:25380275T>A	ENST00000311936.3	-	3	374	c.183A>T	c.(181-183)caA>caT	p.Q61H	KRAS_ENST00000557334.1_Intron|KRAS_ENST00000256078.4_Missense_Mutation_p.Q61H	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	61			Q -> H (in lung carcinoma; dbSNP:rs17851045).|Q -> R (in a colorectal cancer sample; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.Q61H(153)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			TGTACTCCTCTTGACCTGCTG	0.423000	Q61H(CL11_LARGE_INTESTINE)|Q61H(HS766T_PANCREAS)|Q61H(NCIH1155_LUNG)|Q61H(NCIH460_LUNG)|Q61H(T3M4_PANCREAS)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			28	27					0	0	1	0	0
OR6M1	390261	broad.mit.edu	37	11	123676459	123676459	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr11:123676459G>A	ENST00000309154.2	-	1	636	c.599C>T	c.(598-600)tCt>tTt	p.S200F		NM_001005325.1	NP_001005325.1	Q8NGM8	OR6M1_HUMAN	olfactory receptor, family 6, subfamily M, member 1	200					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|prostate(2)|skin(5)|urinary_tract(1)	29		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.028)		GACAAGGGCAGAGAGGAGAAA	0.463000													9	16					0	0	1	0	0
DNAJC2	27000	broad.mit.edu	37	7	102960085	102960085	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr7:102960085C>T	ENST00000379263.3	-	12	1463	c.1213G>A	c.(1213-1215)Gaa>Aaa	p.E405K	DNAJC2_ENST00000249270.7_Intron|PMPCB_ENST00000420236.2_Intron	NM_014377.1	NP_055192.1	Q99543	DNJC2_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 2	405					'de novo' cotranslational protein folding|chromatin modification|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nuclear membrane	chromatin binding|DNA binding|histone binding|Hsp70 protein binding|ubiquitin binding			endometrium(1)|kidney(9)|large_intestine(6)|lung(4)|ovary(1)	21						TTTCCTACTTCTTTTGTGCAT	0.353000													6	21					0	0	1	0	0
NSUN3	63899	broad.mit.edu	37	3	93783294	93783294	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:93783294C>T	ENST00000314622.4	+	2	237	c.26C>T	c.(25-27)tCa>tTa	p.S9L	NSUN3_ENST00000485793.1_3'UTR	NM_022072.3	NP_071355.1	Q9H649	NSUN3_HUMAN	NOP2/Sun domain family, member 3	9							methyltransferase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|skin(1)	18						AAAGCAAAATCAGAGGGGAAG	0.358000													3	19					0	0	1	0	0
KIF15	56992	broad.mit.edu	37	3	44867555	44867555	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:44867555G>C	ENST00000326047.4	+	21	2723	c.2574G>C	c.(2572-2574)gaG>gaC	p.E858D	KIF15_ENST00000425755.1_Missense_Mutation_p.E493D	NM_020242.2	NP_064627.1	Q9NS87	KIF15_HUMAN	kinesin family member 15	858					blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(5)	36				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)		AGCTGCTTGAGAGCAAAGCCT	0.303000													10	30					0	0	1	0	0
ADAM19	8728	broad.mit.edu	37	5	156997912	156997912	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr5:156997912C>T	ENST00000257527.4	-	2	249	c.171G>A	c.(169-171)gtG>gtA	p.V57V	ADAM19_ENST00000394020.1_Silent_p.V59V|ADAM19_ENST00000517905.1_Silent_p.V57V|ADAM19_ENST00000430702.2_5'UTR	NM_033274.3	NP_150377.1	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19	57					proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	53	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CCTTTTCTCTCACGGGGCTTT	0.468000													10	41					0	0	1	0	0
ZBED4	9889	broad.mit.edu	37	22	50279822	50279822	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr22:50279822G>A	ENST00000216268.5	+	2	2989	c.2512G>A	c.(2512-2514)Gag>Aag	p.E838K		NM_014838.2	NP_055653.2	O75132	ZBED4_HUMAN	zinc finger, BED-type containing 4							cytoplasm|nucleus	DNA binding|metal ion binding|protein dimerization activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(11)|lung(20)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_cancers(38;8.58e-10)|all_epithelial(38;1.15e-08)|all_lung(38;0.000109)|Lung NSC(38;0.0018)|Breast(42;0.00191)|Ovarian(80;0.0164)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)|BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		GATCGTCAGCGAGGCCATTAA	0.627000													8	19					0	0	1	0	0
ABHD16A	7920	broad.mit.edu	37	6	31655472	31655472	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr6:31655472G>T	ENST00000375842.4	-	18	1822	c.836C>A	c.(835-837)tCt>tAt	p.S279Y	ABHD16A_ENST00000395952.3_Missense_Mutation_p.S498Y|XXbac-BPG32J3.20_ENST00000461287.1_3'UTR|ABHD16A_ENST00000440843.2_Missense_Mutation_p.S465Y|ABHD16A_ENST00000471644.1_5'UTR			O95870	ABHGA_HUMAN	abhydrolase domain containing 16A	498						integral to membrane	hydrolase activity|protein binding			endometrium(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)	10						GCGGAGGACAGACAGACACCA	0.622000													7	31					0.0293803	0.0296252	1	1	0
NBPF15	284565	broad.mit.edu	37	1	148594513	148594513	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr1:148594513G>A	ENST00000442702.2	+	21	2953	c.1886G>A	c.(1885-1887)aGa>aAa	p.R629K	NBPF15_ENST00000369187.3_Missense_Mutation_p.R629K	NM_001170755.1	NP_001164226.1	Q8N660	NBPFF_HUMAN	neuroblastoma breakpoint family, member 15	629	NBPF 6.					cytoplasm				NS(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|skin(2)	12	all_hematologic(923;0.032)					CAGCACTACAGAAGTGTGTTT	0.438000													61	176					0	0	1	0	0
FRMD4A	55691	broad.mit.edu	37	10	13749043	13749043	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr10:13749043G>A	ENST00000357447.2	-	13	1198	c.830C>T	c.(829-831)cCa>cTa	p.P277L	FRMD4A_ENST00000342409.2_Missense_Mutation_p.P293L|FRMD4A_ENST00000492155.1_5'UTR|FRMD4A_ENST00000378503.1_Missense_Mutation_p.P277L|FRMD4A_ENST00000358621.4_Missense_Mutation_p.P262L	NM_018027.3	NP_060497.3	Q9P2Q2	FRM4A_HUMAN	FERM domain containing 4A	277	FERM.					cytoplasm|cytoskeleton	binding			breast(4)|endometrium(9)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	41						TTACCTGCGTGGGTCATGAAC	0.458000													7	22					0	0	1	0	0
EPHA2	1969	broad.mit.edu	37	1	16460034	16460034	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr1:16460034C>T	ENST00000358432.5	-	10	1960	c.1806G>A	c.(1804-1806)ttG>ttA	p.L602L		NM_004431.3	NP_004422.2	P29317	EPHA2_HUMAN	EPH receptor A2	602					activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	42		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	TAGTGAACTTCAACACAGCCT	0.597000													9	29					0	0	1	0	0
GBX2	2637	broad.mit.edu	37	2	237075028	237075028	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr2:237075028C>T	ENST00000551105.1	-	3	650	c.613G>A	c.(613-615)Gaa>Aaa	p.E205K	GBX2_ENST00000465889.1_5'UTR|GBX2_ENST00000306318.4_Silent_p.P192P			P52951	GBX2_HUMAN	gastrulation brain homeobox 2	0						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)	7		Breast(86;0.00235)|Renal(207;0.00339)|all_hematologic(139;0.00357)|all_lung(227;0.0616)|Acute lymphoblastic leukemia(138;0.0775)|Ovarian(221;0.089)|Lung NSC(271;0.179)		Epithelial(121;4.5e-25)|OV - Ovarian serous cystadenocarcinoma(60;5.16e-11)|BRCA - Breast invasive adenocarcinoma(100;3.4e-05)|Lung(119;0.00195)|LUSC - Lung squamous cell carcinoma(224;0.00471)		CCTTGCCCTTCGGGTCGTCTT	0.562000													25	73					0	0	1	0	0
ZNF282	8427	broad.mit.edu	37	7	148895581	148895581	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr7:148895581G>A	ENST00000262085.3	+	2	427	c.322G>A	c.(322-324)Gtg>Atg	p.V108M	ZNF282_ENST00000479907.1_Missense_Mutation_p.V108M	NM_003575.2	NP_003566.1	Q9UDV7	ZN282_HUMAN	zinc finger protein 282	108					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(3)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	17	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)	Lung(243;0.145)		CATTCAGGCTGTGGAGAGGAA	0.627000													11	28					0	0	1	0	0
PEAK1	79834	broad.mit.edu	37	15	77472113	77472113	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr15:77472113G>A	ENST00000560626.2	-	4	2631	c.2156C>T	c.(2155-2157)tCa>tTa	p.S719L	PEAK1_ENST00000558305.1_Missense_Mutation_p.S719L|PEAK1_ENST00000312493.4_Missense_Mutation_p.S719L			Q9H792	PEAK1_HUMAN	pseudopodium-enriched atypical kinase 1	719					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding										TCTCTGTGGTGAAGACTGACC	0.483000													20	69					0	0	1	0	0
PTPRN2	5799	broad.mit.edu	37	7	157369412	157369412	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr7:157369412C>T	ENST00000389413.3	-	18	2692	c.2589G>A	c.(2587-2589)ctG>ctA	p.L863L	PTPRN2_ENST00000389418.4_Silent_p.L892L|PTPRN2_ENST00000389416.4_Silent_p.L875L|PTPRN2_ENST00000409483.1_Silent_p.L854L|PTPRN2_ENST00000404321.2_Silent_p.L915L	NM_130843.2	NP_570858.2	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	892	Tyrosine-protein phosphatase.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		GCAGGTTCTTCAGATAGAAGC	0.592000													3	7					0	0	1	0	0
ZKSCAN5	23660	broad.mit.edu	37	7	99104064	99104064	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr7:99104064G>C	ENST00000394170.2	+	2	648	c.397G>C	c.(397-399)Gag>Cag	p.E133Q	ZKSCAN5_ENST00000451158.1_Missense_Mutation_p.E133Q|ZKSCAN5_ENST00000326775.5_Missense_Mutation_p.E133Q	NM_014569.3	NP_055384.1	Q9Y2L8	ZKSC5_HUMAN	zinc finger with KRAB and SCAN domains 5	133					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	21	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					GCGAGAACTTGAGGAACGCAG	0.517000													8	25					0	0	1	0	0
ENDOV	284131	broad.mit.edu	37	17	78399393	78399393	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr17:78399393G>T	ENST00000518137.1	+	7	715	c.687G>T	c.(685-687)agG>agT	p.R229S	ENDOV_ENST00000522751.1_Missense_Mutation_p.R35S|ENDOV_ENST00000520284.1_Missense_Mutation_p.R35S|ENDOV_ENST00000517795.1_Missense_Mutation_p.R35S|ENDOV_ENST00000323854.5_Missense_Mutation_p.R184S|ENDOV_ENST00000520367.1_Missense_Mutation_p.R184S|ENDOV_ENST00000518907.1_Missense_Mutation_p.R35S|ENDOV_ENST00000517295.2_Missense_Mutation_p.R157S|ENDOV_ENST00000518901.1_Missense_Mutation_p.R35S	NM_173627.3	NP_775898.2	Q8N8Q3	ENDOV_HUMAN	endonuclease V	229					DNA repair		endodeoxyribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding			endometrium(1)|lung(1)|pancreas(1)|prostate(1)	4						GCTGCTGCAGGTTCCGGATCC	0.687000								Direct reversal of damage					4	7					0.00909568	0.00924855	1	1	0
OR10H2	26538	broad.mit.edu	37	19	15839117	15839117	+	Silent	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr19:15839117C>G	ENST00000305899.3	+	1	284	c.264C>G	c.(262-264)acC>acG	p.T88T		NM_013939.2	NP_039227.1	O60403	O10H2_HUMAN	olfactory receptor, family 10, subfamily H, member 2	88					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|skin(3)|stomach(1)	27	all_hematologic(1;0.0517)|Acute lymphoblastic leukemia(2;0.074)					TGCTGTCCACCCAGCGCTCCA	0.612000													11	31					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57325507	57325507	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr19:57325507C>T	ENST00000326441.9	-	10	4666	c.4303G>A	c.(4303-4305)Gag>Aag	p.E1435K	ZIM2_ENST00000599935.1_Intron|PEG3_ENST00000598410.1_Missense_Mutation_p.E1311K|ZIM2_ENST00000601070.1_Intron|ZIM2_ENST00000391708.3_Intron|PEG3_ENST00000423103.2_Missense_Mutation_p.E1435K|PEG3_ENST00000593695.1_Missense_Mutation_p.E1309K|ZIM2_ENST00000593711.1_Intron|ZIM2_ENST00000221722.5_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	1435	4 X 5 AA repeat of P-X-G-E-A.|Glu-rich.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TGTCCAGCCTCTCCAATGGGC	0.587000													17	40					0	0	1	0	0
HERC5	51191	broad.mit.edu	37	4	89407344	89407344	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr4:89407344G>C	ENST00000264350.3	+	14	1969	c.1816G>C	c.(1816-1818)Gaa>Caa	p.E606Q	HERC5_ENST00000508159.1_Missense_Mutation_p.E244Q	NM_016323.3	NP_057407.2	Q9UII4	HERC5_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 5	606					innate immune response|ISG15-protein conjugation|negative regulation of type I interferon production|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cyclin-dependent protein kinase activity|regulation of defense response to virus|response to virus	cytosol|perinuclear region of cytoplasm	ISG15 ligase activity|protein binding|ubiquitin-protein ligase activity			NS(2)|breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(11)|liver(2)|lung(17)|ovary(4)|prostate(1)|skin(4)	53		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000209)		TTTTTTTGTAGAAGTATGCAG	0.363000													10	36					0	0	1	0	0
SMC1A	8243	broad.mit.edu	37	X	53409191	53409191	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chrX:53409191C>G	ENST00000322213.4	-	22	3526	c.3399G>C	c.(3397-3399)aaG>aaC	p.K1133N	SMC1A_ENST00000469129.1_5'UTR	NM_006306.2	NP_006297.2	Q14683	SMC1A_HUMAN	structural maintenance of chromosomes 1A	1133	Ala/Asp-rich (DA-box).				cell cycle checkpoint|cell division|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic sister chromatid cohesion|mitotic spindle organization|negative regulation of DNA endoreduplication|nuclear mRNA splicing, via spliceosome|response to radiation|signal transduction in response to DNA damage	cohesin core heterodimer|condensed chromosome kinetochore|condensed nuclear chromosome|cytoplasm|meiotic cohesin complex|nucleoplasm	ATP binding|chromatin binding|microtubule motor activity|protein heterodimerization activity			NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(8)|ovary(5)|upper_aerodigestive_tract(2)	49						CTGCCACTGTCTTCTCCCCGC	0.572000													20	12					0	0	1	0	0
RAC1	5879	broad.mit.edu	37	7	6431634	6431634	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr7:6431634G>A	ENST00000348035.4	+	3	400	c.187G>A	c.(187-189)Gat>Aat	p.D63N	RAC1_ENST00000356142.4_Missense_Mutation_p.D63N|RAC1_ENST00000488373.1_3'UTR	NM_006908.4	NP_008839.2	P63000	RAC1_HUMAN	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	63			D -> G (in dbSNP:rs5831).		actin filament polymerization|apoptosis|axon guidance|cell motility|cell-matrix adhesion|induction of apoptosis by extracellular signals|inflammatory response|lamellipodium assembly|localization within membrane|negative regulation of interleukin-23 production|negative regulation of receptor-mediated endocytosis|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of lamellipodium assembly|positive regulation of Rho protein signal transduction|regulation of cell migration|regulation of defense response to virus by virus|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|ruffle organization|small GTPase mediated signal transduction|T cell costimulation|viral reproduction	cytosol|melanosome|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity|thioesterase binding			cervix(1)|endometrium(1)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	8		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.104)	Pravastatin(DB00175)|Simvastatin(DB00641)	TGGACAAGAAGATTATGACAG	0.393000													13	38					0	0	1	0	0
SPAST	6683	broad.mit.edu	37	2	32289061	32289061	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr2:32289061C>G	ENST00000315285.3	+	1	286	c.161C>G	c.(160-162)tCc>tGc	p.S54C	SPAST_ENST00000345662.1_Missense_Mutation_p.S54C	NM_014946.3	NP_055761.2	Q9UBP0	SPAST_HUMAN	spastin	54	Required for interaction with ATL1.|Required for interaction with RTN1.|Required for interaction with SSNA1 and microtubules.|Required for midbody localization.				cell cycle|cell death|cell differentiation|cytokinesis, completion of separation|ER to Golgi vesicle-mediated transport|microtubule bundle formation|microtubule severing|nervous system development|protein hexamerization|protein homooligomerization	endoplasmic reticulum|endosome|integral to membrane|microtubule|microtubule organizing center|nucleus|perinuclear region of cytoplasm|spindle	alpha-tubulin binding|ATP binding|beta-tubulin binding|microtubule binding|microtubule-severing ATPase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(8)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					TACTATTTCTCCTACCCGCTG	0.701000													3	24					0	0	1	0	0
CXXC11	285093	broad.mit.edu	37	2	242814595	242814595	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr2:242814595C>T	ENST00000343216.3	+	2	916	c.888C>T	c.(886-888)ctC>ctT	p.L296L		NM_173821.2	NP_776182.2	Q14D33	CB085_HUMAN	CXXC finger protein 11	296						integral to membrane											GGGGCTCCCTCTGCAGCCCGG	0.657000													16	50					0	0	1	0	0
ICAM1	3383	broad.mit.edu	37	19	10395089	10395089	+	Silent	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr19:10395089G>A	ENST00000264832.3	+	5	1261	c.936G>A	c.(934-936)gcG>gcA	p.A312A	ICAM1_ENST00000423829.2_Silent_p.A90A|CTD-2369P2.5_ENST00000592893.1_RNA	NM_000201.2	NP_000192.2	P05362	ICAM1_HUMAN	intercellular adhesion molecule 1	312					adhesion to symbiont|heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking|positive regulation of cellular extravasation|regulation of immune response|regulation of leukocyte mediated cytotoxicity|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|virion attachment, binding of host cell surface receptor	extracellular space|integral to plasma membrane	integrin binding|transmembrane receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(20;1.39e-09)|Epithelial(33;2.81e-06)|all cancers(31;6.56e-06)		Natalizumab(DB00108)|Simvastatin(DB00641)	GCTTTCCGGCGCCCAACGTGA	0.612000													24	63					0	0	1	0	0
TMEM33	55161	broad.mit.edu	37	4	41946903	41946903	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr4:41946903G>A	ENST00000504986.1	+	5	855	c.490G>A	c.(490-492)Gaa>Aaa	p.E164K	TMEM33_ENST00000325094.5_Missense_Mutation_p.E164K|TMEM33_ENST00000513702.1_Missense_Mutation_p.E164K	NM_018126.2	NP_060596.2	P57088	TMM33_HUMAN	transmembrane protein 33	164						integral to membrane|melanosome	protein binding			endometrium(1)|large_intestine(3)|lung(4)|ovary(1)	9						TGCTTGCAATGAAATATTCCT	0.348000													9	23					0	0	1	0	0
OBP2A	29991	broad.mit.edu	37	9	138439746	138439746	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr9:138439746G>C	ENST00000539850.1	+	4	333	c.307G>C	c.(307-309)Gag>Cag	p.E103Q	OBP2A_ENST00000340780.3_Missense_Mutation_p.E103Q|OBP2A_ENST00000342114.4_Missense_Mutation_p.G58A|OBP2A_ENST00000371776.1_Missense_Mutation_p.E103Q			Q9NY56	OBP2A_HUMAN	odorant binding protein 2A	103					response to stimulus|sensory perception of smell	extracellular region	odorant binding|transporter activity			endometrium(1)|large_intestine(4)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	11				OV - Ovarian serous cystadenocarcinoma(145;3.39e-07)|Epithelial(140;1.11e-06)|all cancers(34;2.04e-05)		ATACCTGCAGGAGCTGCCCGG	0.602000													16	20					0	0	1	0	0
PYGO1	26108	broad.mit.edu	37	15	55838477	55838477	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr15:55838477G>A	ENST00000302000.6	-	3	1098	c.1004C>T	c.(1003-1005)tCg>tTg	p.S335L	PYGO1_ENST00000563719.1_Missense_Mutation_p.S335L	NM_015617.1	NP_056432.1	Q9Y3Y4	PYGO1_HUMAN	pygopus family PHD finger 1	335					Wnt receptor signaling pathway	nucleus	zinc ion binding			endometrium(4)|kidney(2)|large_intestine(6)|lung(6)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	27				all cancers(107;0.0131)|GBM - Glioblastoma multiforme(80;0.18)		GTCAGAAGACGAATGGCCATG	0.473000													37	100					0	0	1	0	0
SPTBN1	6711	broad.mit.edu	37	2	54859802	54859802	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr2:54859802G>C	ENST00000333896.5	+	16	4010	c.3625G>C	c.(3625-3627)Gag>Cag	p.E1209Q	SPTBN1_ENST00000356805.4_Missense_Mutation_p.E1222Q	NM_178313.2	NP_842565.2	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1	1222					actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			NS(1)|breast(8)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(27)|ovary(4)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	82			Lung(47;0.24)			GGACGCCAATGAGGAGAAGAT	0.507000													10	26					0	0	1	0	0
ZNF226	7769	broad.mit.edu	37	19	44679701	44679701	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr19:44679701G>C	ENST00000590089.1	+	7	653	c.286G>C	c.(286-288)Gaa>Caa	p.E96Q	ZNF226_ENST00000337433.5_Missense_Mutation_p.E96Q|ZNF226_ENST00000454662.2_Missense_Mutation_p.E96Q|ZNF226_ENST00000588883.1_3'UTR			Q9NYT6	ZN226_HUMAN	zinc finger protein 226	96					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						Prostate(69;0.0352)|all_neural(266;0.202)				AGAATCAGAAGAAGAGCTTTC	0.353000													4	24					0	0	1	0	0
TST	7263	broad.mit.edu	37	22	37407283	37407283	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr22:37407283C>G	ENST00000403892.3	-	2	1413	c.679G>C	c.(679-681)Gaa>Caa	p.E227Q	TST_ENST00000249042.3_Missense_Mutation_p.E227Q	NM_001270483.1	NP_001257412.1	Q16762	THTR_HUMAN	thiosulfate sulfurtransferase (rhodanese)	227	Rhodanese 2.				cyanate catabolic process|rRNA transport	mitochondrial matrix|plasma membrane	5S rRNA binding|thiosulfate sulfurtransferase activity			kidney(1)|large_intestine(1)|lung(2)|prostate(1)|skin(1)|urinary_tract(1)	7						CGGAGCTCTTCTGGGCCCTTC	0.612000													10	21					0	0	1	0	0
MAP3K10	4294	broad.mit.edu	37	19	40715101	40715101	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr19:40715101C>T	ENST00000253055.3	+	6	1815	c.1527C>T	c.(1525-1527)atC>atT	p.I509I		NM_002446.3	NP_002437.2	Q02779	M3K10_HUMAN	mitogen-activated protein kinase kinase kinase 10	509					activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	24						GCCCCAGCATCATCCCCCGGC	0.547000													15	42					0	0	1	0	0
EXOC3L4	91828	broad.mit.edu	37	14	103566869	103566869	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr14:103566869G>A	ENST00000380069.3	+	1	389	c.313G>A	c.(313-315)Gag>Aag	p.E105K		NM_001077594.1	NP_001071062.1	Q17RC7	EX3L4_HUMAN	exocyst complex component 3-like 4	105										cervix(2)|endometrium(2)|lung(4)|ovary(1)|skin(1)	10						GGCCACTCCTGAGGTGCCCTC	0.627000													4	17					0	0	1	0	0
ADH1B	125	broad.mit.edu	37	4	100235052	100235052	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr4:100235052G>A	ENST00000305046.8	-	6	821	c.754C>T	c.(754-756)Cag>Tag	p.Q252*	ADH1B_ENST00000394887.3_Nonsense_Mutation_p.Q212*			P00325	ADH1B_HUMAN	alcohol dehydrogenase 1B (class I), beta polypeptide	252					ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(12)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	33				OV - Ovarian serous cystadenocarcinoma(123;1.02e-07)	Fomepizole(DB01213)|NADH(DB00157)	AGCACTTCCTGAATGGGTTTC	0.458000													62	174					0	0	1	0	0
CCDC144A	9720	broad.mit.edu	37	17	16612182	16612182	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr17:16612182C>T	ENST00000443444.2	+	5	951	c.811C>T	c.(811-813)Cat>Tat	p.H271Y	CCDC144A_ENST00000360524.8_Missense_Mutation_p.H271Y|RP11-219A15.1_ENST00000448331.3_Missense_Mutation_p.H271Y|CCDC144A_ENST00000340621.5_Missense_Mutation_p.H270Y|CCDC144A_ENST00000456009.1_Intron|CCDC144A_ENST00000399273.1_Missense_Mutation_p.H271Y			A2RUR9	C144A_HUMAN	coiled-coil domain containing 144A	271																	AGTACTTCCTCATGTGCAAAA	0.368000													10	42					0	0	1	0	0
COX15	1355	broad.mit.edu	37	10	101487208	101487208	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr10:101487208C>A	ENST00000370483.5	-	3	435	c.385G>T	c.(385-387)Gaa>Taa	p.E129*	CUTC_ENST00000493385.1_Intron|COX15_ENST00000016171.5_Nonsense_Mutation_p.E129*	NM_004376.5|NM_078470.4	NP_004367.2|NP_510870.1	Q7KZN9	COX15_HUMAN	cytochrome c oxidase assembly homolog 15 (yeast)	129					heme a biosynthetic process|respiratory chain complex IV assembly|respiratory gaseous exchange	integral to membrane|mitochondrial respiratory chain	cytochrome-c oxidase activity			endometrium(1)|kidney(1)|large_intestine(4)|liver(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	13		Colorectal(252;0.234)		Epithelial(162;3.08e-10)|all cancers(201;2.43e-08)		ATTTTAAATTCTGGAAATTGC	0.378000													4	33					0.150653	0.150965	1	1	0
OBSCN	84033	broad.mit.edu	37	1	228474535	228474535	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr1:228474535G>C	ENST00000570156.2	+	40	10700	c.10626G>C	c.(10624-10626)ttG>ttC	p.L3542F	OBSCN_ENST00000366709.4_Missense_Mutation_p.L232F|OBSCN_ENST00000366707.4_Missense_Mutation_p.L232F|OBSCN_ENST00000359599.6_Missense_Mutation_p.L1960F|OBSCN_ENST00000284548.11_Missense_Mutation_p.L3113F|OBSCN_ENST00000422127.1_Missense_Mutation_p.L3113F	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	2575	Ig-like 36.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GTGAGGACTTGACCCTGGTGT	0.617000													13	41					0	0	1	0	0
LRRC56	115399	broad.mit.edu	37	11	552575	552575	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr11:552575C>T	ENST00000270115.7	+	13	1688	c.1188C>T	c.(1186-1188)ctC>ctT	p.L396L		NM_198075.3	NP_932341.1	Q8IYG6	LRC56_HUMAN	leucine rich repeat containing 56	396										kidney(1)|lung(4)|skin(1)	6		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CTAGCCCCCTCCCCTATAGGC	0.652000													5	8					0	0	1	0	0
ABCA8	10351	broad.mit.edu	37	17	66902287	66902287	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr17:66902287C>G	ENST00000269080.2	-	17	2313	c.2176G>C	c.(2176-2178)Gat>Cat	p.D726H	ABCA8_ENST00000586539.1_Missense_Mutation_p.D766H|ABCA8_ENST00000430352.2_Missense_Mutation_p.D766H	NM_007168.2	NP_009099.1	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	726						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances	p.D726Y(1)		breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					GGATAGCTATCAAGATCCTTG	0.313000													12	20					0	0	1	0	0
SOX4	6659	broad.mit.edu	37	6	21595094	21595094	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr6:21595094G>C	ENST00000244745.1	+	1	1123	c.329G>C	c.(328-330)cGa>cCa	p.R110P	SOX4_ENST00000543472.1_Missense_Mutation_p.R110P	NM_003107.2	NP_003098.1	Q06945	SOX4_HUMAN	SRY (sex determining region Y)-box 4	110					canonical Wnt receptor signaling pathway|cardiac ventricle formation|cellular response to glucose stimulus|DNA damage response, detection of DNA damage|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|glial cell development|glial cell proliferation|limb bud formation|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of protein export from nucleus|negative regulation of protein ubiquitination|neural tube formation|neuroepithelial cell differentiation|noradrenergic neuron differentiation|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|positive regulation of insulin secretion|positive regulation of N-terminal peptidyl-lysine acetylation|positive regulation of translation|pro-B cell differentiation|protein stabilization|skeletal system development|spinal cord motor neuron differentiation|sympathetic nervous system development|T cell differentiation	mitochondrion|nucleus	core promoter sequence-specific DNA binding|protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription coactivator activity			kidney(2)|lung(2)|prostate(1)|upper_aerodigestive_tract(1)	6	Ovarian(93;0.163)		all cancers(50;0.0751)|Epithelial(50;0.155)			CCTTTCATTCGAGAGGCGGAG	0.597000													6	16					0	0	1	0	0
PCDHB5	26167	broad.mit.edu	37	5	140517198	140517198	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr5:140517198G>A	ENST00000231134.5	+	1	2399	c.2182G>A	c.(2182-2184)Gag>Aag	p.E728K		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		728					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTCGGTGCCCGAGGGCCCCTT	0.667000													43	157					0	0	1	0	0
OR10J1	26476	broad.mit.edu	37	1	159410479	159410479	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr1:159410479C>T	ENST00000423932.3	+	1	968	c.931C>T	c.(931-933)Ctg>Ttg	p.L311L	RP11-550P17.5_ENST00000431862.1_RNA	NM_012351.2	NP_036483.2	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J, member 1	311					sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)|stomach(1)	25	all_hematologic(112;0.0429)					CAAAGATGCTCTGTGCAGGGC	0.488000													17	39					0	0	1	0	0
DZIP1L	199221	broad.mit.edu	37	3	137787080	137787080	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:137787080G>A	ENST00000327532.2	-	13	2107	c.1745C>T	c.(1744-1746)tCc>tTc	p.S582F		NM_173543.2	NP_775814.2	Q8IYY4	DZI1L_HUMAN	DAZ interacting zinc finger protein 1-like	582						intracellular	zinc ion binding			breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|pancreas(2)|prostate(1)|skin(1)	35						GGTCAGGCTGGAGCCATGGCT	0.692000													18	48					0	0	1	0	0
SOX30	11063	broad.mit.edu	37	5	157078940	157078940	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr5:157078940C>T	ENST00000265007.6	-	1	488	c.147G>A	c.(145-147)gcG>gcA	p.A49A	SOX30_ENST00000311371.5_Silent_p.A49A|SOX30_ENST00000519442.1_Intron	NM_178424.1	NP_848511.1	O94993	SOX30_HUMAN	SRY (sex determining region Y)-box 30	49					regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|response to corticosteroid stimulus|transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	23	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGGCCAAGGTCGCACTGGCTG	0.711000													3	2					0	0	1	0	0
GOLIM4	27333	broad.mit.edu	37	3	167812963	167812963	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:167812963C>T	ENST00000470487.1	-	1	800	c.111G>A	c.(109-111)caG>caA	p.Q37Q	GOLIM4_ENST00000309027.4_Silent_p.Q37Q	NM_014498.3	NP_055313.1	O00461	GOLI4_HUMAN	golgi integral membrane protein 4	37					transport	cis-Golgi network|endocytic vesicle|endosome membrane|Golgi cisterna membrane|Golgi lumen|integral to membrane|nucleus				breast(5)|endometrium(2)|large_intestine(8)|lung(26)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						GCAGCTGCGTCTGCAGCTCGT	0.622000													7	25					0	0	1	0	0
PPP6R3	55291	broad.mit.edu	37	11	68343463	68343463	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr11:68343463C>T	ENST00000393799.2	+	14	1764	c.1497C>T	c.(1495-1497)ttC>ttT	p.F499F	PPP6R3_ENST00000265636.5_Silent_p.F448F|PPP6R3_ENST00000393801.3_Silent_p.F499F|PPP6R3_ENST00000524904.1_Silent_p.F499F|PPP6R3_ENST00000529710.1_Silent_p.F448F|PPP6R3_ENST00000393800.2_Silent_p.F499F|PPP6R3_ENST00000524845.1_Silent_p.F499F|PPP6R3_ENST00000534534.1_Silent_p.F267F|PPP6R3_ENST00000265637.4_Silent_p.F499F|PPP6R3_ENST00000527403.2_Silent_p.F499F			Q5H9R7	PP6R3_HUMAN	protein phosphatase 6, regulatory subunit 3	499					regulation of phosphoprotein phosphatase activity	cytoplasm|nucleus	protein phosphatase binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(10)|liver(2)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37						GGGAGACGTTCTGCACAAGCT	0.428000													11	44					0	0	1	0	0
TBX5	6910	broad.mit.edu	37	12	114793779	114793779	+	Missense_Mutation	SNP	G	G	A	rs143068551	by1000genomes	TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr12:114793779G>A	ENST00000310346.4	-	9	1781	c.1115C>T	c.(1114-1116)tCg>tTg	p.S372L	TBX5_ENST00000405440.2_Missense_Mutation_p.S372L|TBX5_ENST00000349716.5_Missense_Mutation_p.S322L	NM_000192.3	NP_000183.2	Q99593	TBX5_HUMAN	T-box 5	372					cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding	p.S372L(1)		endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(29)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		CCGCTGTGCCGACTCTGTCCT	0.592000													16	73					0	0	1	0	0
RXRA	6256	broad.mit.edu	37	9	137328351	137328351	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr9:137328351C>T	ENST00000540193.1	+	9	1912	c.989C>T	c.(988-990)tCc>tTc	p.S330F	RXRA_ENST00000356384.4_3'UTR|RXRA_ENST00000481739.1_Missense_Mutation_p.S427F			P19793	RXRA_HUMAN	retinoid X receptor, alpha	427	Ligand-binding.				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	GCTCTGCGCTCCATCGGGCTC	0.607000													42	37					0	0	1	0	0
GRM2	2912	broad.mit.edu	37	3	51746773	51746773	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:51746773G>C	ENST00000395052.3	+	3	969	c.735G>C	c.(733-735)atG>atC	p.M245I	GRM2_ENST00000475478.1_Intron|GRM2_ENST00000442933.2_Missense_Mutation_p.M245I	NM_000839.3	NP_000830.2	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2	245					synaptic transmission	integral to plasma membrane				breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	GCCGTGCCATGAGCCGCGCGG	0.652000													4	25					0	0	1	0	0
ADAM20	8748	broad.mit.edu	37	14	70989893	70989893	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr14:70989893G>C	ENST00000256389.3	-	2	1976	c.1732C>G	c.(1732-1734)Cag>Gag	p.Q578E	RP11-486O13.4_ENST00000556646.1_lincRNA	NM_003814.4	NP_003805.3	O43506	ADA20_HUMAN	ADAM metallopeptidase domain 20	528	Cys-rich.				proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|prostate(1)|skin(2)	27			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		TAGCAACTCTGAGATGCACTC	0.408000													20	50					0	0	1	0	0
KIAA1161	57462	broad.mit.edu	37	9	34372277	34372277	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr9:34372277C>T	ENST00000297625.7	-	2	788	c.563G>A	c.(562-564)gGg>gAg	p.G188E		NM_020702.3	NP_065753.2	Q6NSJ0	K1161_HUMAN	KIAA1161	222					carbohydrate metabolic process	integral to membrane	hydrolase activity, hydrolyzing O-glycosyl compounds			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)	12			LUSC - Lung squamous cell carcinoma(29;0.0107)	GBM - Glioblastoma multiforme(74;0.126)		GAGGATGCCCCCAAACGCGGC	0.652000													13	4					0	0	1	0	0
MYO1A	4640	broad.mit.edu	37	12	57423364	57423364	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr12:57423364G>A	ENST00000442789.2	-	27	3019	c.2732C>T	c.(2731-2733)tCt>tTt	p.S911F	MYO1A_ENST00000300119.3_Missense_Mutation_p.S911F|MYO1A_ENST00000544473.1_Missense_Mutation_p.S749F	NM_001256041.1	NP_001242970.1	Q9UBC5	MYO1A_HUMAN	myosin IA	911					sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(17)|ovary(2)|skin(7)|urinary_tract(3)	50						GAGAATCCGAGAAGAAGTCTA	0.552000													14	58					0	0	1	0	0
ZNF282	8427	broad.mit.edu	37	7	148895662	148895662	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr7:148895662G>A	ENST00000262085.3	+	2	508	c.403G>A	c.(403-405)Gac>Aac	p.D135N	ZNF282_ENST00000479907.1_Missense_Mutation_p.D135N	NM_003575.2	NP_003566.1	Q9UDV7	ZN282_HUMAN	zinc finger protein 282	135					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(3)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	17	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)	Lung(243;0.145)		GAAGCTGGCCGACTGTGAAAA	0.647000													16	63					0	0	1	0	0
CHERP	10523	broad.mit.edu	37	19	16652789	16652789	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr19:16652789C>G	ENST00000546361.2	-	2	242	c.91G>C	c.(91-93)Gag>Cag	p.E31Q	CHERP_ENST00000198939.6_Missense_Mutation_p.E31Q|CTD-3222D19.2_ENST00000409035.1_Intron	NM_006387.5	NP_006378.3	Q8IWX8	CHERP_HUMAN	calcium homeostasis endoplasmic reticulum protein	31					cellular calcium ion homeostasis|negative regulation of cell proliferation|nervous system development|RNA processing	endoplasmic reticulum|perinuclear region of cytoplasm	RNA binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(9)|ovary(2)|stomach(1)|urinary_tract(3)	24						GTCATCTTCTCAAACTCGGGC	0.542000													19	32					0	0	1	0	0
ZNF282	8427	broad.mit.edu	37	7	148895586	148895586	+	Silent	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr7:148895586G>A	ENST00000262085.3	+	2	432	c.327G>A	c.(325-327)gaG>gaA	p.E109E	ZNF282_ENST00000479907.1_Silent_p.E109E	NM_003575.2	NP_003566.1	Q9UDV7	ZN282_HUMAN	zinc finger protein 282	109					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(3)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	17	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)	Lung(243;0.145)		AGGCTGTGGAGAGGAAGGTGG	0.622000													10	27					0	0	1	0	0
LAMC1	3915	broad.mit.edu	37	1	183087224	183087224	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr1:183087224C>G	ENST00000258341.4	+	11	2190	c.1933C>G	c.(1933-1935)Cag>Gag	p.Q645E		NM_002293.3	NP_002284.3	P11047	LAMC1_HUMAN	laminin, gamma 1 (formerly LAMB2)	645	Laminin IV type A.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(27)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	76					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTTTGAATTTCAGAAGCTCCT	0.403000													8	33					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76570876	76570876	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr17:76570876G>C	ENST00000389840.5	-	2	388	c.264C>G	c.(262-264)aaC>aaG	p.N88K	DNAH17_ENST00000585328.1_Missense_Mutation_p.N88K					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			AGTTGTCCTTGTTGATGTTCT	0.592000													16	58					0	0	1	0	0
SSRP1	6749	broad.mit.edu	37	11	57094292	57094292	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr11:57094292G>A	ENST00000278412.2	-	16	2209	c.1943C>T	c.(1942-1944)tCa>tTa	p.S648L	RP11-872D17.4_ENST00000534162.1_RNA	NM_003146.2	NP_003137.1	Q08945	SSRP1_HUMAN	structure specific recognition protein 1	648	Ser-rich.				DNA repair|DNA replication|positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|cytoplasm|nucleoplasm	DNA binding|protein binding			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(6)|ovary(2)|prostate(4)	23						CGACTTGGATGATGAGCCCCT	0.468000													13	30					0	0	1	0	0
AMZ2	51321	broad.mit.edu	37	17	66250580	66250580	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr17:66250580G>A	ENST00000359904.3	+	5	1754	c.622G>A	c.(622-624)Gat>Aat	p.D208N	AMZ2_ENST00000359783.4_Missense_Mutation_p.D150N|AMZ2_ENST00000585050.1_Intron|AMZ2_ENST00000577985.1_Missense_Mutation_p.D208N|AMZ2_ENST00000392720.2_Missense_Mutation_p.D208N|AMZ2_ENST00000577866.1_Missense_Mutation_p.D208N|AMZ2_ENST00000577273.1_Intron|AMZ2_ENST00000580753.1_Missense_Mutation_p.D208N	NM_016627.4	NP_057711.3	Q86W34	AMZ2_HUMAN	archaelysin family metallopeptidase 2	208							metallopeptidase activity|zinc ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)	9	all_cancers(12;1.12e-09)		BRCA - Breast invasive adenocarcinoma(8;3.17e-08)|LUSC - Lung squamous cell carcinoma(166;0.24)			GTATGGCAGTGATTTTTATAG	0.368000													7	22					0	0	1	0	0
RAB11B	9230	broad.mit.edu	37	19	8467368	8467368	+	Splice_Site	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr19:8467368G>A	ENST00000328024.6	+	4	648		c.e4-1		RAB11B_ENST00000594216.1_Splice_Site|RAB11B_ENST00000601897.1_Splice_Site	NM_004218.3	NP_004209.2	Q15907	RB11B_HUMAN	RAB11B, member RAS oncogene family						cell cycle|protein transport|small GTPase mediated signal transduction	plasma membrane	GDP binding|GTP binding|GTPase activity			large_intestine(2)|lung(1)|ovary(1)	4						CTTTGTTCCAGAAAAGAACAA	0.567000													15	27					0	0	1	0	0
MAGEB16	139604	broad.mit.edu	37	X	35820609	35820609	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chrX:35820609C>G	ENST00000399989.1	+	2	575	c.296C>G	c.(295-297)tCa>tGa	p.S99*	MAGEB16_ENST00000399985.1_Nonsense_Mutation_p.S99*|MAGEB16_ENST00000399987.1_Nonsense_Mutation_p.S99*|MAGEB16_ENST00000399988.1_Nonsense_Mutation_p.S99*|MAGEB16_ENST00000399992.1_Nonsense_Mutation_p.S131*	NM_001099921.1	NP_001093391.1	A2A368	MAGBG_HUMAN	melanoma antigen family B, 16	99										breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(16)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31						CCAAGCTCCTCAGAGGATACA	0.478000													6	6					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195501094	195501094	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:195501094G>C	ENST00000463781.3	-	4	13485	c.13026C>G	c.(13024-13026)ttC>ttG	p.F4342L	MUC4_ENST00000346145.4_Missense_Mutation_p.F106L|MUC4_ENST00000475231.1_Missense_Mutation_p.F4342L|MUC4_ENST00000349607.4_Missense_Mutation_p.F55L	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	1099					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TCGCCGGCTTGAAGAGTGGGG	0.657000													11	42					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49422657	49422657	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr12:49422657C>A	ENST00000301067.7	-	45	14335	c.14336G>T	c.(14335-14337)gGa>gTa	p.G4779V		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		CACCTCACTTCCTTTGCCCTT	0.562000													35	110					1.90571e-15	2.05426e-15	1	1	0
PFKP	5214	broad.mit.edu	37	10	3172046	3172046	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr10:3172046C>T	ENST00000381075.2	+	19	1919	c.1695C>T	c.(1693-1695)acC>acT	p.T565T	PFKP_ENST00000381072.1_5'UTR|PFKP_ENST00000381125.4_Silent_p.T573T	NM_001242339.1	NP_001229268.1	Q01813	K6PP_HUMAN	phosphofructokinase, platelet	573					glycolysis	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|metal ion binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(3)|large_intestine(3)|lung(10)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(1;0.000975)|all cancers(11;0.00351)|Epithelial(11;0.142)		CCAGCGGAACCAAGCGGCGCG	0.652000													20	74					0	0	1	0	0
PHLPP2	23035	broad.mit.edu	37	16	71710366	71710366	+	Silent	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr16:71710366G>C	ENST00000393524.2	-	8	2188	c.1455C>G	c.(1453-1455)ctC>ctG	p.L485L	PHLPP2_ENST00000568954.1_Silent_p.L485L|PHLPP2_ENST00000356272.3_Silent_p.L485L|PHLPP2_ENST00000567016.1_Silent_p.L520L|PHLPP2_ENST00000360429.3_Silent_p.L485L			Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein phosphatase 2	485						cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(7)|lung(15)|ovary(1)|prostate(1)|skin(1)|stomach(1)	37						AACTGGCATAGAGGGTCCGAA	0.498000													11	26					0	0	1	0	0
PEAK1	79834	broad.mit.edu	37	15	77471636	77471636	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr15:77471636G>A	ENST00000560626.2	-	4	3108	c.2633C>T	c.(2632-2634)tCt>tTt	p.S878F	PEAK1_ENST00000558305.1_Missense_Mutation_p.S878F|PEAK1_ENST00000312493.4_Missense_Mutation_p.S878F			Q9H792	PEAK1_HUMAN	pseudopodium-enriched atypical kinase 1	878					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding										ATGGTAAGGAGAAGAAGTAGA	0.532000													18	53					0	0	1	0	0
GPER1	2852	broad.mit.edu	37	7	1132276	1132276	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr7:1132276C>T	ENST00000397092.1	+	3	1796	c.912C>T	c.(910-912)ctC>ctT	p.L304L	GPER1_ENST00000297469.3_Silent_p.L304L|C7orf50_ENST00000397098.3_Intron|GPER1_ENST00000401670.1_Silent_p.L304L|C7orf50_ENST00000397100.2_Intron|GPER1_ENST00000397088.3_Silent_p.L304L|C7orf50_ENST00000488073.1_Intron|C7orf50_ENST00000357429.6_Intron	NM_001039966.1	NP_001035055.1			G protein-coupled estrogen receptor 1	304																	CCCACCCCCTCACGGGCCACA	0.632000													21	43					0	0	1	0	0
STAG2	10735	broad.mit.edu	37	X	123195159	123195159	+	Nonsense_Mutation	SNP	T	T	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chrX:123195159T>A	ENST00000371160.1	+	16	1792	c.1502T>A	c.(1501-1503)tTg>tAg	p.L501*	STAG2_ENST00000371157.3_Nonsense_Mutation_p.L501*|STAG2_ENST00000218089.9_Nonsense_Mutation_p.L501*|STAG2_ENST00000371145.3_Nonsense_Mutation_p.L501*|STAG2_ENST00000354548.5_Nonsense_Mutation_p.L432*|STAG2_ENST00000371144.3_Nonsense_Mutation_p.L501*|STAG2_ENST00000469481.1_Intron	NM_001282418.1	NP_001269347.1	Q8N3U4	STAG2_HUMAN	stromal antigen 2	501					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(9)|lung(21)|ovary(5)|prostate(2)|skin(5)|urinary_tract(4)	78						ATGAATAGCTTGTTACTGGAA	0.363000													18	14					0	0	1	0	0
STYK1	55359	broad.mit.edu	37	12	10782155	10782155	+	Silent	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr12:10782155G>A	ENST00000075503.3	-	6	1090	c.570C>T	c.(568-570)ctC>ctT	p.L190L		NM_018423.2	NP_060893.2	Q6J9G0	STYK1_HUMAN	serine/threonine/tyrosine kinase 1	190	Protein kinase.					integral to membrane|plasma membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|liver(1)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	26						ACACCATATAGAGTGGCAGCT	0.527000										HNSCC(73;0.22)			7	17					0	0	1	0	0
MBTPS1	8720	broad.mit.edu	37	16	84088129	84088129	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr16:84088129C>T	ENST00000343411.3	-	23	3579	c.3084G>A	c.(3082-3084)ccG>ccA	p.P1028P		NM_003791.2	NP_003782.1	Q14703	MBTP1_HUMAN	membrane-bound transcription factor peptidase, site 1	1028	Arg/Lys/Pro-rich (basic).				cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|lung(10)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						TCCTCCGCTTCGGCCTGCTCT	0.622000													9	23					0	0	1	0	0
PNPLA1	285848	broad.mit.edu	37	6	36269737	36269737	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr6:36269737G>A	ENST00000394571.2	+	6	875	c.875G>A	c.(874-876)cGc>cAc	p.R292H	PNPLA1_ENST00000388715.3_Missense_Mutation_p.R197H|PNPLA1_ENST00000312917.5_Missense_Mutation_p.R206H	NM_001145717.1	NP_001139189.2	Q8N8W4	PLPL1_HUMAN	patatin-like phospholipase domain containing 1	292					lipid catabolic process		hydrolase activity			breast(1)|kidney(1)|large_intestine(4)|lung(9)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)	22						TGCCCTGAACGCAGTCAACCA	0.547000											OREG0017382	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	28					0	0	1	0	0
PKN3	29941	broad.mit.edu	37	9	131469665	131469665	+	Silent	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr9:131469665G>A	ENST00000291906.4	+	6	1209	c.816G>A	c.(814-816)gtG>gtA	p.V272V		NM_013355.3	NP_037487.2	Q6P5Z2	PKN3_HUMAN	protein kinase N3	272					signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein binding|protein kinase C activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	24						GGACACCTGTGAAGCCCACCG	0.592000													16	9					0	0	1	0	0
RFX4	5992	broad.mit.edu	37	12	106977123	106977123	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr12:106977123C>T	ENST00000392842.1	+	1	439	c.25C>T	c.(25-27)Ccc>Tcc	p.P9S	RP11-144F15.1_ENST00000551505.1_Intron	NM_213594.2	NP_998759.1	Q33E94	RFX4_HUMAN	regulatory factor X, 4 (influences HLA class II expression)	9					transcription, DNA-dependent	nucleus	DNA binding			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(20)|pancreas(1)|upper_aerodigestive_tract(1)	35						ACTGGAGGAACCCGACATGGA	0.557000													17	50					0	0	1	0	0
HECTD2	143279	broad.mit.edu	37	10	93244276	93244276	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr10:93244276G>C	ENST00000446394.1	+	10	946	c.846G>C	c.(844-846)aaG>aaC	p.K282N	HECTD2_ENST00000298068.5_Missense_Mutation_p.K278N|HECTD2_ENST00000498446.1_3'UTR|HECTD2_ENST00000371667.1_5'UTR|HECTD2_ENST00000536715.1_5'UTR	NM_001284274.1	NP_001271203.1	Q5U5R9	HECD2_HUMAN	HECT domain containing E3 ubiquitin protein ligase 2	278					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			breast(2)|endometrium(2)|kidney(4)|large_intestine(10)|lung(7)|skin(1)|urinary_tract(1)	27						TGTCCCAGAAGAGGTTCAAAC	0.338000													12	23					0	0	1	0	0
DDHD1	80821	broad.mit.edu	37	14	53529876	53529876	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr14:53529876G>C	ENST00000357758.3	-	7	1734	c.1551C>G	c.(1549-1551)ttC>ttG	p.F517L	DDHD1_ENST00000323669.5_Missense_Mutation_p.F517L|DDHD1_ENST00000395606.1_Missense_Mutation_p.F524L	NM_030637.2	NP_085140.2	Q8NEL9	DDHD1_HUMAN	DDHD domain containing 1	517					lipid catabolic process	cytoplasm	hydrolase activity|metal ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)	25	Breast(41;0.037)					TCCGAGAACAGAAAAGGGAAT	0.368000													7	39					0	0	1	0	0
NRCAM	4897	broad.mit.edu	37	7	107847975	107847975	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr7:107847975C>A	ENST00000379028.3	-	13	1674	c.1204G>T	c.(1204-1206)Gaa>Taa	p.E402*	NRCAM_ENST00000413765.2_Nonsense_Mutation_p.E383*|NRCAM_ENST00000379024.4_Nonsense_Mutation_p.E383*|NRCAM_ENST00000425651.2_Nonsense_Mutation_p.E402*|NRCAM_ENST00000379022.4_Nonsense_Mutation_p.E402*|NRCAM_ENST00000351718.4_Nonsense_Mutation_p.E396*			Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule	402	Ig-like 4.				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			breast(4)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|liver(1)|lung(36)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	65						AACTTACTTTCTATTGGGACT	0.403000													17	31					1.56452e-12	1.68273e-12	1	1	0
ZNF737	100129842	broad.mit.edu	37	19	20727783	20727783	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr19:20727783G>A	ENST00000427401.4	-	4	1320	c.1226C>T	c.(1225-1227)tCc>tTc	p.S409F		NM_001159293.1	NP_001152765.1	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	409					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(2)|kidney(1)|lung(7)|ovary(1)|stomach(1)|urinary_tract(1)	13						AAGGGAAGAGGAGTACTTAAA	0.418000													6	13					0	0	1	0	0
CYP26B1	56603	broad.mit.edu	37	2	72360313	72360313	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr2:72360313G>C	ENST00000001146.2	-	5	1188	c.985C>G	c.(985-987)Cat>Gat	p.H329D	CYP26B1_ENST00000412253.1_Missense_Mutation_p.H138D|CYP26B1_ENST00000546307.1_Missense_Mutation_p.H254D	NM_001277742.1|NM_019885.2	NP_001264671.1|NP_063938.1	Q9NR63	CP26B_HUMAN	cytochrome P450, family 26, subfamily B, polypeptide 1	329					cell fate determination|embryonic limb morphogenesis|male meiosis|negative regulation of retinoic acid receptor signaling pathway|proximal/distal pattern formation|retinoic acid catabolic process|spermatogenesis|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			breast(1)|kidney(3)|large_intestine(2)|lung(16)|ovary(2)|prostate(2)|skin(2)	28						AGGATGCCATGAGCCCGCAGC	0.652000													9	18					0	0	1	0	0
KLK12	43849	broad.mit.edu	37	19	51535195	51535195	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr19:51535195C>A	ENST00000525263.1	-	3	513	c.394G>T	c.(394-396)Gac>Tac	p.D132Y	KLK12_ENST00000250351.4_Missense_Mutation_p.D132Y|CTC-518B2.9_ENST00000594910.1_RNA|KLK12_ENST00000319590.4_Missense_Mutation_p.D132Y|KLK12_ENST00000250352.11_Intron|KLK12_ENST00000529888.1_Intron			Q9UKR0	KLK12_HUMAN	kallikrein-related peptidase 12	132	Peptidase S1.				proteolysis	extracellular region|soluble fraction	serine-type endopeptidase activity			endometrium(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	12		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00399)		GTTGCACAGTCATTGGGCAGG	0.692000													23	49					9.57634e-11	1.0277e-10	1	1	0
PRDM9	56979	broad.mit.edu	37	5	23518025	23518025	+	Missense_Mutation	SNP	C	C	T	rs62342743		TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr5:23518025C>T	ENST00000296682.3	+	5	519	c.337C>T	c.(337-339)Cgt>Tgt	p.R113C		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	113					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						AGTGGAACAGCGTAAACACCA	0.408000										HNSCC(3;0.000094)			20	59					0	0	1	0	0
PEAK1	79834	broad.mit.edu	37	15	77471280	77471280	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr15:77471280G>C	ENST00000560626.2	-	4	3464	c.2989C>G	c.(2989-2991)Caa>Gaa	p.Q997E	PEAK1_ENST00000558305.1_Missense_Mutation_p.Q997E|PEAK1_ENST00000312493.4_Missense_Mutation_p.Q997E			Q9H792	PEAK1_HUMAN	pseudopodium-enriched atypical kinase 1	997					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding										AGCTGGCCTTGAGCAGGGTCG	0.542000													6	25					0	0	1	0	0
RAB6B	51560	broad.mit.edu	37	3	133557043	133557043	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:133557043C>T	ENST00000285208.4	-	6	811	c.462G>A	c.(460-462)gaG>gaA	p.E154E	RAB6B_ENST00000543906.1_Silent_p.E154E|RAB6B_ENST00000469959.1_Intron|RAB6B_ENST00000486858.1_Silent_p.E141E	NM_016577.3	NP_057661.3	Q9NRW1	RAB6B_HUMAN	RAB6B, member RAS oncogene family	154					protein transport|retrograde vesicle-mediated transport, Golgi to ER|small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle|Golgi membrane	GTP binding|GTPase activity|protein binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|pancreas(1)	11						TCGCACTGGTCTCAATGAACA	0.612000													51	104					0	0	1	0	0
RPN1	6184	broad.mit.edu	37	3	128356737	128356737	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:128356737G>A	ENST00000296255.3	-	3	586	c.538C>T	c.(538-540)Cga>Tga	p.R180*	RPN1_ENST00000497289.1_Nonsense_Mutation_p.R8*	NM_002950.3	NP_002941.1	P04843	RPN1_HUMAN	ribophorin I	180					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|melanosome|oligosaccharyltransferase complex|rough microsome	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(2)|ovary(2)|stomach(2)	13				GBM - Glioblastoma multiforme(114;0.189)		TCCACATTTCGAGAGGCAAGC	0.507000			T	EVI1	AML								9	43					0	0	1	0	0
TBC1D12	23232	broad.mit.edu	37	10	96162370	96162370	+	Translation_Start_Site	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr10:96162370G>A	ENST00000225235.4	+	0	110					NM_015188.1	NP_056003.1	O60347	TBC12_HUMAN	TBC1 domain family, member 12							intracellular	Rab GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|upper_aerodigestive_tract(2)	20		Colorectal(252;0.0429)				CCCACCCCCAGATGGTGGGTC	0.697000													4	21					0	0	1	0	0
C20orf26	26074	broad.mit.edu	37	20	20243771	20243771	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr20:20243771G>A	ENST00000245957.5	+	21	2576	c.2500G>A	c.(2500-2502)Gaa>Aaa	p.E834K	C20orf26_ENST00000377293.1_Missense_Mutation_p.E190K|C20orf26_ENST00000377309.2_Missense_Mutation_p.E190K|C20orf26_ENST00000389656.3_Missense_Mutation_p.E190K|RP5-1096J16.1_ENST00000460400.1_RNA	NM_015585.3	NP_056400.3	Q8NHU2	CT026_HUMAN	chromosome 20 open reading frame 26	834										NS(2)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(42)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	77				READ - Rectum adenocarcinoma(2;0.171)		CATCACCACAGAAGGTAAGGA	0.403000													13	43					0	0	1	0	0
SIGLEC10	89790	broad.mit.edu	37	19	51914577	51914577	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr19:51914577G>C	ENST00000353836.5	-	10	1806	c.1585C>G	c.(1585-1587)Ctt>Gtt	p.L529V	SIGLEC10_ENST00000442846.3_Missense_Mutation_p.L381V|SIGLEC10_ENST00000432469.2_Missense_Mutation_p.L446V|SIGLEC10_ENST00000339313.5_Missense_Mutation_p.L624V|SIGLEC10_ENST00000356298.5_Missense_Mutation_p.L624V|SIGLEC10_ENST00000439889.2_Missense_Mutation_p.L566V|SIGLEC10_ENST00000441969.3_Missense_Mutation_p.L471V|SIGLEC10_ENST00000525998.1_Missense_Mutation_p.L439V|SIGLEC10_ENST00000436984.2_Missense_Mutation_p.L481V	NM_001171157.1|NM_001171158.1|NM_001171159.1	NP_001164628.1|NP_001164629.1|NP_001164630.1	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10	624					cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding	p.L624F(1)|p.L566F(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(27)|ovary(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		CCTGGTGGAAGAGGGGTCCGA	0.493000													18	56					0	0	1	0	0
ARHGEF2	9181	broad.mit.edu	37	1	155927654	155927654	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr1:155927654G>A	ENST00000462460.2	-	17	1954	c.1700C>T	c.(1699-1701)tCg>tTg	p.S567L	ARHGEF2_ENST00000361247.4_Missense_Mutation_p.S522L|ARHGEF2_ENST00000477754.2_Intron|ARHGEF2_ENST00000313667.4_Missense_Mutation_p.S521L|ARHGEF2_ENST00000368316.1_Missense_Mutation_p.S494L|ARHGEF2_ENST00000313695.7_Missense_Mutation_p.S494L|ARHGEF2_ENST00000368315.4_Missense_Mutation_p.S523L			Q92974	ARHG2_HUMAN	Rho/Rac guanine nucleotide exchange factor (GEF) 2		PH.				actin filament organization|apoptosis|cell division|cell morphogenesis|induction of apoptosis by extracellular signals|intracellular protein transport|mitosis|negative regulation of microtubule depolymerization|nerve growth factor receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|regulation of cell proliferation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|Golgi apparatus|microtubule|ruffle membrane|spindle|tight junction	microtubule binding|Rac GTPase binding|Rac guanyl-nucleotide exchange factor activity|zinc ion binding			breast(4)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|skin(2)	40	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					ATTCTGCAGCGATACCACTGA	0.522000													4	15					0	0	1	0	0
DDX4	54514	broad.mit.edu	37	5	55109582	55109582	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr5:55109582C>T	ENST00000505374.1	+	19	1789	c.1697C>T	c.(1696-1698)tCa>tTa	p.S566L	DDX4_ENST00000511853.1_Missense_Mutation_p.S417L|DDX4_ENST00000514278.2_Missense_Mutation_p.S546L|DDX4_ENST00000353507.5_Missense_Mutation_p.S532L|DDX4_ENST00000354991.5_Missense_Mutation_p.S532L	NM_024415.2	NP_077726.1	Q9NQI0	DDX4_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4	566	Helicase C-terminal.				multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(8)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)	24		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)				GAAAAAATATCAACTACAAGT	0.284000													15	27					0	0	1	0	0
AKAP4	8852	broad.mit.edu	37	X	49958593	49958593	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chrX:49958593G>T	ENST00000376056.2	-	5	894	c.744C>A	c.(742-744)aaC>aaA	p.N248K	AKAP4_ENST00000376064.3_Missense_Mutation_p.N248K|AKAP4_ENST00000481402.1_5'UTR|AKAP4_ENST00000376058.2_Intron|AKAP4_ENST00000358526.2_Missense_Mutation_p.N257K			Q5JQC9	AKAP4_HUMAN	A kinase (PRKA) anchor protein 4	257					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			NS(2)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(6)|lung(14)|ovary(1)|skin(4)	41	Ovarian(276;0.236)					TTCTCTCTTTGTTCCCAGGGG	0.473000													21	12					6.21321e-17	6.7275e-17	1	1	0
RNF215	200312	broad.mit.edu	37	22	30782063	30782063	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr22:30782063C>T	ENST00000382363.3	-	3	571	c.497G>A	c.(496-498)cGa>cAa	p.R166Q		NM_001017981.1	NP_001017981.1	Q9Y6U7	RN215_HUMAN	ring finger protein 215	166						integral to membrane	zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(2)	6						ATTTACCTCTCGGACCACGTT	0.607000													3	8					0	0	1	0	0
MEX3B	84206	broad.mit.edu	37	15	82335694	82335694	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr15:82335694G>T	ENST00000329713.4	-	2	1952	c.1517C>A	c.(1516-1518)tCt>tAt	p.S506Y	MEX3B_ENST00000558133.1_3'UTR	NM_032246.4	NP_115622.2	Q6ZN04	MEX3B_HUMAN	mex-3 RNA binding family member B	506					protein autophosphorylation	cytoplasmic mRNA processing body|nucleus	calcium ion binding|RNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|upper_aerodigestive_tract(1)	19						CCCggaggaagaggatgaaga	0.647000													5	17					0.014758	0.0149432	1	1	0
OR51V1	283111	broad.mit.edu	37	11	5221700	5221700	+	Silent	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr11:5221700G>A	ENST00000321255.1	-	1	230	c.231C>T	c.(229-231)ctC>ctT	p.L77L		NM_001004760.2	NP_001004760.2	Q9H2C8	O51V1_HUMAN	olfactory receptor, family 51, subfamily V, member 1	77					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(13)|lung(19)|skin(2)|upper_aerodigestive_tract(2)	39		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.83e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACAGGTCAGTGAGGGCCAGCA	0.537000													26	52					0	0	1	0	0
FNBP1L	54874	broad.mit.edu	37	1	93998614	93998614	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr1:93998614G>C	ENST00000260506.8	+	8	926	c.775G>C	c.(775-777)Gat>Cat	p.D259H	FNBP1L_ENST00000604705.1_Missense_Mutation_p.D259H|FNBP1L_ENST00000370253.2_Missense_Mutation_p.D259H|FNBP1L_ENST00000271234.7_Missense_Mutation_p.D259H|FNBP1L_ENST00000370256.4_Missense_Mutation_p.D259H	NM_001024948.2|NM_017737.4	NP_001020119.1|NP_060207.2	Q5T0N5	FBP1L_HUMAN	formin binding protein 1-like	259	Induction of membrane tubulation (By similarity).|Interaction with CDC42.				endocytosis	cell cortex|cytoplasmic membrane-bounded vesicle|cytoskeleton|plasma membrane	lipid binding			breast(2)|kidney(2)|large_intestine(4)|lung(2)|urinary_tract(1)	11		all_lung(203;0.00206)|Lung NSC(277;0.00902)|Melanoma(281;0.155)		all cancers(265;0.00666)|GBM - Glioblastoma multiforme(16;0.0378)|Epithelial(280;0.111)		AAAATCAGTTGATGAAAGAAG	0.353000													11	26					0	0	1	0	0
LOC101927079	101927079	broad.mit.edu	37	15	22332464	22332464	+	RNA	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr15:22332464C>G	ENST00000558896.1	+	0	271																											GGCCTATCATCTTCTTGGGAG	0.368000													14	49					0	0	1	0	0
PTX3	5806	broad.mit.edu	37	3	157155332	157155332	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:157155332C>T	ENST00000295927.3	+	2	306	c.161C>T	c.(160-162)tCg>tTg	p.S54L	VEPH1_ENST00000362010.2_Intron|VEPH1_ENST00000543418.1_Intron|VEPH1_ENST00000392832.2_Intron|VEPH1_ENST00000392833.2_Intron	NM_002852.3	NP_002843.2	P26022	PTX3_HUMAN	pentraxin 3, long	54					inflammatory response	extracellular region				central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(4)|stomach(1)	10			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			CAGGAGCACTCGGAATGGGAC	0.607000													3	12					0	0	1	0	0
DEPDC1B	55789	broad.mit.edu	37	5	59895041	59895041	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr5:59895041G>A	ENST00000265036.5	-	10	1356	c.1289C>T	c.(1288-1290)tCa>tTa	p.S430L	DEPDC1B_ENST00000453022.2_Intron|DEPDC1B_ENST00000545085.1_Intron	NM_018369.2	NP_060839.2	Q8WUY9	DEP1B_HUMAN	DEP domain containing 1B	430					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(2)|skin(2)	17		Lung NSC(810;0.000214)|Prostate(74;0.0147)|Breast(144;0.0991)|Ovarian(174;0.17)				ACGGCAAAATGATGGAGCAGA	0.373000													6	24					0	0	1	0	0
NECAP1	25977	broad.mit.edu	37	12	8242793	8242793	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr12:8242793G>A	ENST00000339754.5	+	3	277	c.199G>A	c.(199-201)Gag>Aag	p.E67K		NM_015509.3	NP_056324.2	Q8NC96	NECP1_HUMAN	NECAP endocytosis associated 1	67					endocytosis|protein transport	clathrin coated vesicle membrane|plasma membrane				cervix(1)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10				Kidney(36;0.0915)		TCTGTCAGGGGAGCTCTTTGC	0.443000													18	40					0	0	1	0	0
DCAF11	80344	broad.mit.edu	37	14	24584927	24584927	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr14:24584927C>G	ENST00000446197.3	+	2	851	c.124C>G	c.(124-126)Ctg>Gtg	p.L42V	DCAF11_ENST00000560171.1_3'UTR|DCAF11_ENST00000559115.1_Missense_Mutation_p.L42V|DCAF11_ENST00000396936.1_5'UTR|DCAF11_ENST00000396941.4_Missense_Mutation_p.L42V	NM_025230.4	NP_079506.3	Q8TEB1	DCA11_HUMAN	DDB1 and CUL4 associated factor 11	42						CUL4 RING ubiquitin ligase complex	protein binding										AGATGTGGATCTGGCCCAGGT	0.617000													32	65					0	0	1	0	0
HOXB2	3212	broad.mit.edu	37	17	46622246	46622246	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr17:46622246C>T	ENST00000330070.4	-	1	1195	c.28G>A	c.(28-30)Ggg>Agg	p.G10R	HOXB-AS1_ENST00000504972.3_RNA|HOXB-AS1_ENST00000435312.1_RNA	NM_002145.3	NP_002136.1	P14652	HXB2_HUMAN	homeobox B2	10					blood circulation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|prostate(1)|skin(1)	11						TTTATAAACCCAATCTCCCTC	0.542000													12	31					0	0	1	0	0
ALDH1A2	8854	broad.mit.edu	37	15	58256230	58256230	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr15:58256230G>C	ENST00000249750.4	-	9	1706	c.939C>G	c.(937-939)ttC>ttG	p.F313L	ALDH1A2_ENST00000537372.1_Missense_Mutation_p.F292L|ALDH1A2_ENST00000559517.1_Missense_Mutation_p.F217L|ALDH1A2_ENST00000558231.1_Missense_Mutation_p.F284L|ALDH1A2_ENST00000347587.3_Missense_Mutation_p.F275L	NM_003888.3	NP_003879.2	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1 family, member A2	313					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(15)|prostate(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	CTTGATTGAAGAACACACCCT	0.567000													7	33					0	0	1	0	0
PRDM5	11107	broad.mit.edu	37	4	121737660	121737660	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr4:121737660C>G	ENST00000264808.3	-	7	1053	c.813G>C	c.(811-813)aaG>aaC	p.K271N	PRDM5_ENST00000515109.1_Missense_Mutation_p.K240N|PRDM5_ENST00000428209.2_Missense_Mutation_p.K240N	NM_018699.2	NP_061169.2	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	271					histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(17)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						TCTTCAGCCTCTTTCCACAGC	0.547000													6	31					0	0	1	0	0
LSG1	55341	broad.mit.edu	37	3	194390755	194390755	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:194390755C>T	ENST00000265245.5	-	2	523	c.209G>A	c.(208-210)gGa>gAa	p.G70E		NM_018385.2	NP_060855.2	Q9H089	LSG1_HUMAN	large 60S subunit nuclear export GTPase 1	70					nuclear export|protein transport	Cajal body|endoplasmic reticulum	GTP binding|hydrolase activity			breast(2)|endometrium(3)|large_intestine(2)|lung(9)	16	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;7.55e-06)		AAACTCTGTTCCTGCAAGTTC	0.428000													25	71					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72821112	72821112	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr16:72821112G>T	ENST00000268489.5	-	10	11735	c.11063C>A	c.(11062-11064)cCc>cAc	p.P3688H	ZFHX3_ENST00000397992.5_Missense_Mutation_p.P2774H|RP5-991G20.1_ENST00000563328.2_RNA	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	3688					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				ACTGTCCTTGGGGCAGCTGGG	0.483000													54	158					1.31171e-36	1.42988e-36	1	1	0
KRBOX4	55634	broad.mit.edu	37	X	46322680	46322680	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chrX:46322680G>A	ENST00000344302.4	+	5	821	c.190G>A	c.(190-192)Gaa>Aaa	p.E64K	KRBOX4_ENST00000360017.5_Missense_Mutation_p.E64K|KRBOX4_ENST00000377919.2_Missense_Mutation_p.E64K|KRBOX4_ENST00000478600.1_Missense_Mutation_p.E64K|KRBOX4_ENST00000298190.6_Missense_Mutation_p.E64K|KRBOX4_ENST00000487081.1_Missense_Mutation_p.E64K	NM_001129898.1|NM_017776.2	NP_001123370.1|NP_060246.2			KRAB box domain containing 4																		GGGACCAGGTGAAGAGTCCTG	0.557000													18	16					0	0	1	0	0
AP1G2	8906	broad.mit.edu	37	14	24035801	24035801	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr14:24035801G>T	ENST00000308724.5	-	2	1054	c.299C>A	c.(298-300)gCc>gAc	p.A100D	AP1G2_ENST00000556277.1_5'UTR|AP1G2_ENST00000397120.3_Missense_Mutation_p.A100D|RP11-66N24.3_ENST00000555968.1_RNA	NM_003917.2	NP_003908.1	O75843	AP1G2_HUMAN	adaptor-related protein complex 1, gamma 2 subunit	100					interspecies interaction between organisms|intracellular protein transport|vesicle-mediated transport	AP-1 adaptor complex|endosome membrane	protein binding|protein transporter activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(10)|lung(4)|ovary(1)|pancreas(1)|stomach(1)	28	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00672)		GAGCAGGTGGGCATCGTGCCT	0.532000													53	194					3.4597e-24	3.76291e-24	1	1	0
ZSCAN2	54993	broad.mit.edu	37	15	85165007	85165007	+	Silent	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr15:85165007G>A	ENST00000448803.2	+	3	1873	c.1581G>A	c.(1579-1581)gaG>gaA	p.E527E	ZSCAN2_ENST00000485222.2_Intron|ZSCAN2_ENST00000541040.1_Intron|ZSCAN2_ENST00000358472.3_Silent_p.E377E|ZSCAN2_ENST00000538076.1_Intron|ZSCAN2_ENST00000327179.6_Silent_p.E526E|ZSCAN2_ENST00000546148.1_Silent_p.E527E	NM_181877.3	NP_870992.2	Q7Z7L9	ZSCA2_HUMAN	zinc finger and SCAN domain containing 2	527					cell differentiation|multicellular organismal development|spermatogenesis|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(7)|liver(2)|lung(4)|ovary(1)|pancreas(1)	19				UCEC - Uterine corpus endometrioid carcinoma (272;0.168)|all cancers(203;5.43e-22)		ACACGGGCGAGAAGCCCTACA	0.597000													32	104					0	0	1	0	0
SUCLA2	8803	broad.mit.edu	37	13	48523157	48523157	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr13:48523157C>A	ENST00000378654.3	-	10	1291	c.1235G>T	c.(1234-1236)cGa>cTa	p.R412L	SUCLA2_ENST00000544100.1_Missense_Mutation_p.R278L|SUCLA2_ENST00000543413.1_Missense_Mutation_p.R354L|SUCLA2_ENST00000534875.1_Missense_Mutation_p.R354L	NM_003850.2	NP_003841.1	Q9P2R7	SUCB1_HUMAN	succinate-CoA ligase, ADP-forming, beta subunit	412					succinyl-CoA pathway|tricarboxylic acid cycle	mitochondrial matrix	ATP binding|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(3)|skin(4)	15		all_cancers(8;1.13e-24)|all_epithelial(8;1.78e-13)|all_lung(13;2.85e-06)|Breast(56;0.000141)|Lung NSC(96;0.000226)|all_hematologic(8;0.000885)|Prostate(109;0.00132)|Acute lymphoblastic leukemia(8;0.0167)|Myeloproliferative disorder(33;0.039)|Hepatocellular(98;0.0556)|Lung SC(185;0.102)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(144;2.1e-06)	Succinic acid(DB00139)	ATCATCGACTCGTGTACCTGT	0.348000													17	63					1.67942e-08	1.77864e-08	1	1	0
WDR66	144406	broad.mit.edu	37	12	122437828	122437828	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr12:122437828C>T	ENST00000288912.4	+	20	4067	c.3213C>T	c.(3211-3213)ttC>ttT	p.F1071F		NM_144668.5	NP_653269.3	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	1071							calcium ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(13)|ovary(2)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		GAGAGGACTTCCTGAGACTGC	0.498000													7	54					0	0	1	0	0
MCM7	4176	broad.mit.edu	37	7	99697298	99697298	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr7:99697298C>T	ENST00000303887.5	-	3	835	c.190G>A	c.(190-192)Gac>Aac	p.D64N	MCM7_ENST00000354230.3_5'UTR|MCM7_ENST00000343023.6_Missense_Mutation_p.D64N	NM_005916.3	NP_005907.3	P33993	MCM7_HUMAN	minichromosome maintenance complex component 7	64					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of phosphorylation|response to DNA damage stimulus|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|protein binding			endometrium(1)|kidney(5)|large_intestine(5)|lung(4)|ovary(1)|stomach(1)	17	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)				Atorvastatin(DB01076)	CAAATTGAGTCCACCAACTCG	0.557000													26	61					0	0	1	0	0
SYNGAP1	8831	broad.mit.edu	37	6	33405756	33405756	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr6:33405756C>T	ENST00000418600.2	+	8	1175	c.1074C>T	c.(1072-1074)ttC>ttT	p.F358F	SYNGAP1_ENST00000293748.5_Silent_p.F358F|SYNGAP1_ENST00000428982.2_Silent_p.F299F|SYNGAP1_ENST00000496374.1_3'UTR	NM_006772.2	NP_006763.2	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1	358					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(15)|ovary(7)|pancreas(1)|stomach(1)|urinary_tract(1)	43						GGCGCCACTTCACAGAGCAGT	0.642000													15	23					0	0	1	0	0
DUSP22	56940	broad.mit.edu	37	6	348190	348190	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr6:348190C>T	ENST00000604971.1	+	3	1155	c.42C>T	c.(40-42)acC>acT	p.T14T	DUSP22_ENST00000419235.2_Silent_p.T117T|DUSP22_ENST00000603453.1_Silent_p.T14T|DUSP22_ENST00000344450.5_Silent_p.T117T|DUSP22_ENST00000605315.1_Silent_p.T14T|DUSP22_ENST00000605863.1_Silent_p.T14T|DUSP22_ENST00000605035.1_Silent_p.T14T			Q9NRW4	DUS22_HUMAN	dual specificity phosphatase 22	117					apoptosis|cell proliferation|inactivation of MAPK activity|multicellular organismal development|positive regulation of JNK cascade|regulation of cell proliferation|transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|skin(2)	26	all_hematologic(77;0.228)	Breast(5;0.0249)|all_hematologic(90;0.0489)		OV - Ovarian serous cystadenocarcinoma(45;0.0277)|BRCA - Breast invasive adenocarcinoma(62;0.0669)		CCCTGCACACCGTGCGTGCTG	0.597000													20	149					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178922324	178922324	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:178922324G>A	ENST00000263967.3	+	6	1250	c.1093G>A	c.(1093-1095)Gaa>Aaa	p.E365K		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	365	C2 PI3K-type.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E365K(6)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			CCATGGAGGAGAACCCTTATG	0.343000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			10	25					0	0	1	0	0
CYP2B6	1555	broad.mit.edu	37	19	41512899	41512899	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr19:41512899G>C	ENST00000324071.4	+	4	581	c.574G>C	c.(574-576)Gat>Cat	p.D192H	CYP2B6_ENST00000330446.5_Intron|CYP2B6_ENST00000593831.1_Intron|CYP2B6_ENST00000598834.1_3'UTR	NM_000767.4	NP_000758.1	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B, polypeptide 6	192					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			NS(1)|breast(1)|endometrium(5)|kidney(1)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	28			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	CCACTACCAAGATCAAGAGTT	0.517000													13	46					0	0	1	0	0
PPP1R16B	26051	broad.mit.edu	37	20	37529305	37529305	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr20:37529305C>G	ENST00000299824.1	+	5	738	c.549C>G	c.(547-549)atC>atG	p.I183M	PPP1R16B_ENST00000373331.2_Missense_Mutation_p.I183M	NM_015568.2	NP_056383.1	Q96T49	PP16B_HUMAN	protein phosphatase 1, regulatory subunit 16B	183					regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			biliary_tract(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(23)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	49		Myeloproliferative disorder(115;0.00878)				TGGATGTCATCGAGACCTGCA	0.557000													7	32					0	0	1	0	0
ANP32D	23519	broad.mit.edu	37	12	48866508	48866508	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr12:48866508G>C	ENST00000266594.1	+	1	61	c.61G>C	c.(61-63)Gaa>Caa	p.E21Q		NM_012404.2	NP_036536.2	O95626	AN32D_HUMAN	acidic (leucine-rich) nuclear phosphoprotein 32 family, member D	21										central_nervous_system(1)|large_intestine(2)|lung(3)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	9						CGATGTGAAAGAACTTTTCCT	0.458000													27	96					0	0	1	0	0
ZNF229	7772	broad.mit.edu	37	19	44933146	44933146	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr19:44933146C>T	ENST00000291187.4	-	6	2114	c.1792G>A	c.(1792-1794)Gtg>Atg	p.V598M	CTC-512J12.4_ENST00000588655.1_RNA|ZNF229_ENST00000588931.1_Missense_Mutation_p.V604M|ZNF229_ENST00000591289.1_Intron	NM_001278510.1	NP_001265439.1	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	604					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(2)|endometrium(6)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	45		Prostate(69;0.0352)				TTCCCACACACGTCACACACG	0.542000													15	44					0	0	1	0	0
UBR5	51366	broad.mit.edu	37	8	103266530	103266530	+	Nonstop_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr8:103266530C>G	ENST00000520539.1	-	59	9006	c.8400G>C	c.(8398-8400)taG>taC	p.*2800Y	UBR5_ENST00000521922.1_Nonstop_Mutation_p.*2793Y|UBR5_ENST00000220959.4_Nonstop_Mutation_p.*2799Y|UBR5_ENST00000518205.1_Nonstop_Mutation_p.*528Y	NM_001282873.1|NM_015902.5	NP_001269802.1|NP_056986.2	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin 5	0					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			NS(1)|breast(13)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(19)|liver(1)|lung(51)|ovary(6)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	124	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			TTTTTATACTCTACACAAAAC	0.323000													4	27					0	0	1	0	0
PDSS1	23590	broad.mit.edu	37	10	27012990	27012990	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr10:27012990G>C	ENST00000376215.5	+	8	822	c.769G>C	c.(769-771)Gca>Cca	p.A257P	PDSS1_ENST00000376203.5_Missense_Mutation_p.A257P	NM_014317.3	NP_055132.2	Q5T2R2	DPS1_HUMAN	prenyl (decaprenyl) diphosphate synthase, subunit 1	257					isoprenoid biosynthetic process|ubiquinone biosynthetic process	mitochondrion	metal ion binding|protein heterodimerization activity			autonomic_ganglia(1)|endometrium(1)|kidney(7)|large_intestine(6)|lung(5)|prostate(1)	21						TGAAAGATTTGCACACTACCT	0.408000													12	36					0	0	1	0	0
GON4L	54856	broad.mit.edu	37	1	155727056	155727056	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr1:155727056G>C	ENST00000437809.1	-	26	5434	c.5312C>G	c.(5311-5313)tCt>tGt	p.S1771C	GON4L_ENST00000368331.1_Missense_Mutation_p.S1771C|GON4L_ENST00000271883.5_Missense_Mutation_p.S1771C	NM_001282856.1	NP_001269785.1	Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	1771	PAH 2.				regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					AAAGAAGATAGAAAACTCATC	0.517000													11	39					0	0	1	0	0
TBCD	6904	broad.mit.edu	37	17	80881555	80881555	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr17:80881555C>G	ENST00000355528.4	+	26	2336	c.2206C>G	c.(2206-2208)Cta>Gta	p.L736V	TBCD_ENST00000539345.2_Missense_Mutation_p.L736V	NM_005993.4	NP_005984.3	Q9BTW9	TBCD_HUMAN	tubulin folding cofactor D	736					'de novo' posttranslational protein folding|adherens junction assembly|negative regulation of cell-substrate adhesion|negative regulation of microtubule polymerization|post-chaperonin tubulin folding pathway|tight junction assembly	adherens junction|cytoplasm|lateral plasma membrane|microtubule|tight junction	beta-tubulin binding|chaperone binding|GTPase activator activity					Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0266)|all_epithelial(8;0.0696)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.18)			CCTGGCTGCTCTATGCAGTGA	0.597000													4	2					0	0	1	0	0
DENND5B	160518	broad.mit.edu	37	12	31540569	31540569	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr12:31540569C>G	ENST00000389082.5	-	21	4057	c.3793G>C	c.(3793-3795)Gaa>Caa	p.E1265Q	DENND5B_ENST00000536562.1_Missense_Mutation_p.E1300Q|DENND5B_ENST00000306833.6_Missense_Mutation_p.E1300Q	NM_144973.3	NP_659410.3	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	1265	RUN 2.					integral to membrane				NS(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						AGTGATCCTTCTAGGACTATG	0.498000													8	16					0	0	1	0	0
LINGO3	645191	broad.mit.edu	37	19	2290251	2290251	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr19:2290251C>T	ENST00000585527.1	-	1	1772	c.1525G>A	c.(1525-1527)Gag>Aag	p.E509K	LINGO3_ENST00000404279.1_Missense_Mutation_p.E509K			P0C6S8	LIGO3_HUMAN	leucine rich repeat and Ig domain containing 3	509						integral to membrane				lung(1)|urinary_tract(1)	2						TTGTGGGCCTCGCCCGGGGTC	0.726000													9	21					0	0	1	0	0
TUBD1	51174	broad.mit.edu	37	17	57955630	57955630	+	Silent	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr17:57955630G>A	ENST00000325752.3	-	5	880	c.603C>T	c.(601-603)ctC>ctT	p.L201L	TUBD1_ENST00000376094.4_Silent_p.L201L|TUBD1_ENST00000539018.1_5'UTR|TUBD1_ENST00000592426.1_Silent_p.L201L|TUBD1_ENST00000340993.6_Silent_p.L201L|TUBD1_ENST00000346141.6_Intron|TUBD1_ENST00000394239.3_Silent_p.L201L	NM_016261.3	NP_057345.2	Q9UJT1	TBD_HUMAN	tubulin, delta 1	201					cell differentiation|microtubule-based movement|multicellular organismal development|protein polymerization|spermatogenesis	centriole|microtubule|nucleus	GTP binding|GTPase activity|structural molecule activity			NS(2)|breast(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|skin(1)|stomach(2)	21	all_cancers(5;3.18e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;9.34e-13)|all cancers(12;1.91e-11)			CATGAAGAAGGAGGGCGTCTG	0.408000													10	52					0	0	1	0	0
RELA	5970	broad.mit.edu	37	11	65423357	65423357	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr11:65423357G>C	ENST00000525693.1	-	9	989	c.927C>G	c.(925-927)ttC>ttG	p.F309L	RELA_ENST00000406246.3_Missense_Mutation_p.F309L|RELA_ENST00000308639.9_Missense_Mutation_p.F306L			Q04206	TF65_HUMAN	v-rel avian reticuloendotheliosis viral oncogene homolog A	309					anti-apoptosis|cellular defense response|cytokine-mediated signaling pathway|defense response to virus|inflammatory response|innate immune response|interspecies interaction between organisms|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of inflammatory response|response to interleukin-1|response to UV-B|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|transcription factor complex	activating transcription factor binding|chromatin binding|identical protein binding|NF-kappaB binding|phosphate binding|protein kinase binding|protein N-terminus binding|repressing transcription factor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(11)|ovary(1)|urinary_tract(1)	19						TGATGCTCTTGAAGGTCTCAT	0.562000													24	69					0	0	1	0	0
STX1B	112755	broad.mit.edu	37	16	31004782	31004782	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr16:31004782C>T	ENST00000215095.5	-	8	792	c.561G>A	c.(559-561)acG>acA	p.T187T	STX1B_ENST00000565419.1_Silent_p.T187T	NM_052874.3	NP_443106.1	P61266	STX1B_HUMAN	syntaxin 1B	187					intracellular protein transport|neurotransmitter transport|synaptic transmission	integral to plasma membrane	extracellular-glutamate-gated ion channel activity|SNAP receptor activity			breast(2)|endometrium(1)|large_intestine(5)|lung(5)	13						GCGCCTGCTTCGTCATCTGTG	0.557000													9	45					0	0	1	0	0
PLK2	10769	broad.mit.edu	37	5	57751553	57751553	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr5:57751553G>A	ENST00000274289.3	-	11	1738	c.1438C>T	c.(1438-1440)Cgg>Tgg	p.R480W	PLK2_ENST00000502671.1_Intron	NM_001252226.1|NM_006622.3	NP_001239155.1|NP_006613.2	Q9NYY3	PLK2_HUMAN	polo-like kinase 2	480					positive regulation of I-kappaB kinase/NF-kappaB cascade		ATP binding|protein binding|protein serine/threonine kinase activity|signal transducer activity			endometrium(7)|large_intestine(7)|lung(5)|ovary(3)|prostate(2)|skin(2)	26		all_cancers(5;1.76e-12)|all_epithelial(5;2.09e-13)|all_lung(5;6.64e-05)|Lung NSC(5;0.000127)|Prostate(74;0.055)|Breast(144;0.0602)|Ovarian(174;0.182)		OV - Ovarian serous cystadenocarcinoma(10;7.03e-37)		AGACATCCCCGAAGAACCCTT	0.438000													4	17					0	0	1	0	0
CBFA2T2	9139	broad.mit.edu	37	20	32212724	32212724	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr20:32212724C>T	ENST00000492345.1	+	8	1472	c.787C>T	c.(787-789)Cag>Tag	p.Q263*	CBFA2T2_ENST00000397800.1_Nonsense_Mutation_p.Q263*|CBFA2T2_ENST00000346541.3_Nonsense_Mutation_p.Q292*|CBFA2T2_ENST00000375279.2_Nonsense_Mutation_p.Q292*|CBFA2T2_ENST00000359606.3_Nonsense_Mutation_p.Q302*|CBFA2T2_ENST00000342704.6_Nonsense_Mutation_p.Q283*|CBFA2T2_ENST00000491618.1_3'UTR			O43439	MTG8R_HUMAN	core-binding factor, runt domain, alpha subunit 2; translocated to, 2	292						nucleus	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(4)|lung(4)|pancreas(1)|prostate(2)|skin(2)	20						TCCACCTCTTCAGCATTACAC	0.527000													13	26					0	0	1	0	0
SPG21	51324	broad.mit.edu	37	15	65266963	65266963	+	Silent	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr15:65266963G>A	ENST00000204566.2	-	5	724	c.429C>T	c.(427-429)ttC>ttT	p.F143F	SPG21_ENST00000433215.2_Silent_p.F143F|SPG21_ENST00000559199.1_5'UTR|SPG21_ENST00000416889.2_Silent_p.F116F	NM_016630.3	NP_057714.1	Q9NZD8	SPG21_HUMAN	spastic paraplegia 21 (autosomal recessive, Mast syndrome)	143					cell death	cytosol|endosome membrane|trans-Golgi network transport vesicle	CD4 receptor binding			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(4)|urinary_tract(1)	10						AAGTTTGGTTGAAGATAGAGG	0.388000													14	28					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179476614	179476614	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr2:179476614C>T	ENST00000589042.1	-	268	50646	c.50422G>A	c.(50422-50424)Gac>Aac	p.D16808N	TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.D7935N|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.D7868N|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.D7743N|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.D15167N|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.D14240N	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	15167	Ig-like 101.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AAGTTACAGTCAGGTCCTGCA	0.443000													12	32					0	0	1	0	0
UCK2	7371	broad.mit.edu	37	1	165865490	165865490	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr1:165865490C>T	ENST00000367879.4	+	4	723	c.420C>T	c.(418-420)ttC>ttT	p.F140F	UCK2_ENST00000372212.4_Intron|UCK2_ENST00000469256.2_5'UTR|UCK2_ENST00000470820.1_5'UTR|RP11-525G13.2_ENST00000455257.2_RNA|UCK2_ENST00000462329.1_3'UTR	NM_012474.4	NP_036606.2	Q9BZX2	UCK2_HUMAN	uridine-cytidine kinase 2	140					pyrimidine base metabolic process|pyrimidine nucleoside salvage	cytosol	ATP binding|phosphotransferase activity, alcohol group as acceptor|uridine kinase activity			breast(1)|endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	10	all_hematologic(923;0.048)|Acute lymphoblastic leukemia(8;0.155)					TCCTGGCCTTCTACTCCCAGG	0.547000													63	129					0	0	1	0	0
AKR7L	246181	broad.mit.edu	37	1	19596083	19596083	+	RNA	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr1:19596083G>C	ENST00000420396.2	-	0	507				AKR7L_ENST00000429712.1_RNA					aldo-keto reductase family 7-like											breast(1)|endometrium(2)|ovary(1)|prostate(1)|urinary_tract(1)	6						GTACCAGCCAGAGGGTTGTAG	0.602000													11	54					0	0	1	0	0
SRCRB4D	136853	broad.mit.edu	37	7	76026974	76026974	+	Silent	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr7:76026974G>A	ENST00000275560.3	-	6	1076	c.729C>T	c.(727-729)ttC>ttT	p.F243F	ZP3_ENST00000336517.4_5'UTR	NM_080744.1	NP_542782.1	Q8WTU2	SRB4D_HUMAN	scavenger receptor cysteine rich domain containing, group B (4 domains)	243	SRCR 2.					extracellular region|membrane	scavenger receptor activity			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(9)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	21						CATAGCCGAAGAAGGCGTTGG	0.701000													13	32					0	0	1	0	0
SAP30BP	29115	broad.mit.edu	37	17	73663474	73663474	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr17:73663474C>T	ENST00000584667.1	+	1	279	c.22C>T	c.(22-24)Ctg>Ttg	p.L8L	SAP30BP_ENST00000579864.1_3'UTR|SAP30BP_ENST00000355423.3_Silent_p.L8L	NM_013260.6	NP_037392.1	Q9UHR5	S30BP_HUMAN	SAP30 binding protein	8					apoptosis|induction of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.L8L(1)		kidney(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)	17	all_cancers(13;6.42e-08)		all cancers(21;4.25e-07)|Epithelial(20;9.57e-07)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			GAAGAATGTTCTGTCGTCTCT	0.607000													12	19					0	0	1	0	0
KHDRBS1	10657	broad.mit.edu	37	1	32498927	32498927	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr1:32498927C>G	ENST00000327300.7	+	4	930	c.763C>G	c.(763-765)Cta>Gta	p.L255V	KHDRBS1_ENST00000492989.1_Missense_Mutation_p.L216V|KHDRBS1_ENST00000307714.8_3'UTR	NM_006559.1	NP_006550.1	Q07666	KHDR1_HUMAN	KH domain containing, RNA binding, signal transduction associated 1	255					cell cycle arrest|cell proliferation|cell surface receptor linked signaling pathway|G2/M transition of mitotic cell cycle|mRNA processing|negative regulation of transcription, DNA-dependent|regulation of RNA export from nucleus|transcription, DNA-dependent	membrane|nucleus	DNA binding|RNA binding|SH3 domain binding|SH3/SH2 adaptor activity			endometrium(4)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)	14		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				CAAGAAATTTCTAGTACCGGT	0.443000													15	36					0	0	1	0	0
EFS	10278	broad.mit.edu	37	14	23828168	23828168	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr14:23828168C>G	ENST00000216733.3	-	5	1775	c.1168G>C	c.(1168-1170)Gac>Cac	p.D390H	EFS_ENST00000429593.2_Missense_Mutation_p.D221H|EFS_ENST00000351354.3_Missense_Mutation_p.D297H	NM_005864.2	NP_005855.1	O43281	EFS_HUMAN	embryonal Fyn-associated substrate	390					cell adhesion|intracellular signal transduction	cytoplasm	SH3 domain binding			endometrium(2)|kidney(1)|large_intestine(1)|liver(1)|lung(5)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)	16	all_cancers(95;7.12e-06)			GBM - Glioblastoma multiforme(265;0.00649)		TGAGCTTTGTCCATGCCCTGC	0.677000													13	47					0	0	1	0	0
COMMD7	149951	broad.mit.edu	37	20	31292656	31292656	+	Silent	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr20:31292656C>G	ENST00000278980.6	-	6	992	c.387G>C	c.(385-387)ctG>ctC	p.L129L	COMMD7_ENST00000446419.2_Silent_p.L128L	NM_001099339.1|NM_053041.2	NP_001092809.1|NP_444269.2	Q86VX2	COMD7_HUMAN	COMM domain containing 7	129					negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription, DNA-dependent|tumor necrosis factor-mediated signaling pathway		NF-kappaB binding			breast(1)|endometrium(1)|lung(3)	5						GGTTAATCATCAGAGTCTGAC	0.468000													11	41					0	0	1	0	0
LPP	4026	broad.mit.edu	37	3	188242482	188242482	+	Silent	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:188242482G>A	ENST00000312675.4	+	5	582	c.336G>A	c.(334-336)gaG>gaA	p.E112E	LPP_ENST00000448637.1_Silent_p.E112E|LPP_ENST00000543006.1_Silent_p.E112E	NM_001167672.1|NM_005578.3	NP_001161144.1|NP_005569.1	Q93052	LPP_HUMAN	LIM domain containing preferred translocation partner in lipoma	112	Pro-rich.				cell adhesion	cytoplasm|focal adhesion|nucleus	protein binding|zinc ion binding		HMGA2/LPP(161)	NS(1)|breast(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(2)	10	all_cancers(143;1.37e-09)|all_hematologic(3;0.0429)|Ovarian(172;0.088)	all_lung(153;0.00139)|Lung NSC(153;0.00202)		GBM - Glioblastoma multiforme(93;0.00602)		CACTTGAGGAGAGGCGCTCCA	0.498000			T	"""HMGA2, MLL, C12orf9"""	"""lipoma, leukemia"""								28	61					0	0	1	0	0
TIE1	7075	broad.mit.edu	37	1	43778256	43778256	+	Silent	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr1:43778256G>A	ENST00000372476.3	+	12	1990	c.1911G>A	c.(1909-1911)gtG>gtA	p.V637V	TIE1_ENST00000433781.2_Silent_p.V282V	NM_001253357.1|NM_005424.4	NP_001240286.1|NP_005415.1	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	637	Fibronectin type-III 2.				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(8)|lung(28)|ovary(3)|prostate(2)|salivary_gland(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	70	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CTGCACACGTGCTTCTGCCCC	0.662000													19	33					0	0	1	0	0
UBR5	51366	broad.mit.edu	37	8	103284993	103284993	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr8:103284993C>T	ENST00000520539.1	-	48	7343	c.6737G>A	c.(6736-6738)cGg>cAg	p.R2246Q	UBR5_ENST00000521922.1_Missense_Mutation_p.R2240Q|UBR5_ENST00000518205.1_5'UTR|UBR5_ENST00000220959.4_Missense_Mutation_p.R2246Q	NM_001282873.1|NM_015902.5	NP_001269802.1|NP_056986.2	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin 5	2246					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			NS(1)|breast(13)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(19)|liver(1)|lung(51)|ovary(6)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	124	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			ATCTCGATCCCGATCAACCTA	0.358000													5	40					0	0	1	0	0
KRT76	51350	broad.mit.edu	37	12	53162728	53162728	+	Silent	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr12:53162728G>A	ENST00000332411.2	-	9	1739	c.1686C>T	c.(1684-1686)gtC>gtT	p.V562V		NM_015848.4	NP_056932.2	Q01546	K22O_HUMAN	keratin 76	562	Tail.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						tgccactgctgacccctccat	0.652000													4	9					0	0	1	0	0
C11orf65	160140	broad.mit.edu	37	11	108276213	108276213	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr11:108276213C>G	ENST00000525729.1	-	4	425	c.356G>C	c.(355-357)aGa>aCa	p.R119T	C11orf65_ENST00000526725.1_5'UTR|C11orf65_ENST00000529391.1_Missense_Mutation_p.R168T|C11orf65_ENST00000393084.1_Missense_Mutation_p.R168T			Q8NCR3	CK065_HUMAN	chromosome 11 open reading frame 65	168										endometrium(1)|large_intestine(3)|lung(4)|ovary(2)	10		all_cancers(61;1.38e-11)|all_epithelial(67;3.16e-07)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;8.21e-06)|BRCA - Breast invasive adenocarcinoma(274;1.01e-05)|all cancers(92;0.000189)|Colorectal(284;0.114)|OV - Ovarian serous cystadenocarcinoma(223;0.144)		ATCTTGCCTTCTCTTCAGTTT	0.328000													8	11					0	0	1	0	0
CDH4	1002	broad.mit.edu	37	20	60508081	60508081	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr20:60508081G>C	ENST00000360469.5	+	14	2366	c.2278G>C	c.(2278-2280)Gag>Cag	p.E760Q	CDH4_ENST00000543233.1_Missense_Mutation_p.E686Q	NM_001794.3	NP_001785.2	P55283	CADH4_HUMAN	cadherin 4, type 1, R-cadherin (retinal)	760					adherens junction organization|cell junction assembly		calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(2)|lung(25)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			GAAGCGGCGAGAGAAGGAGCG	0.627000													17	38					0	0	1	0	0
ESPN	83715	broad.mit.edu	37	1	6505938	6505938	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr1:6505938C>G	ENST00000377828.1	+	7	1575	c.1407C>G	c.(1405-1407)atC>atG	p.I469M	RP1-202O8.2_ENST00000419034.1_RNA	NM_031475.2	NP_113663.2	B1AK53	ESPN_HUMAN	espin	469	Pro-rich.				sensory perception of sound	brush border|cytoplasm|filamentous actin|stereocilium	actin filament binding|SH3 domain binding			NS(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|skin(1)	17	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;3.6e-37)|all_epithelial(116;2.56e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|all_hematologic(16;6.92e-06)|Colorectal(325;4.47e-05)|Acute lymphoblastic leukemia(12;4.92e-05)|Breast(487;7.61e-05)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)		Epithelial(90;1.82e-35)|GBM - Glioblastoma multiforme(13;3e-28)|Kidney(185;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(229;5.63e-08)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;1.41e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000109)|STAD - Stomach adenocarcinoma(132;0.00167)|Lung(427;0.0108)|LUSC - Lung squamous cell carcinoma(448;0.0253)|READ - Rectum adenocarcinoma(331;0.0419)		CAGCTGACATCTACATGCAGA	0.662000													22	54					0	0	1	0	0
IL18RAP	8807	broad.mit.edu	37	2	103053812	103053812	+	Silent	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr2:103053812G>A	ENST00000264260.2	+	6	1309	c.720G>A	c.(718-720)gtG>gtA	p.V240V	IL18RAP_ENST00000409369.1_Silent_p.V98V	NM_003853.2	NP_003844.1	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	240					cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(5)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(4)	37						TTGTTCAAGTGAGAACCATTG	0.378000													13	26					0	0	1	0	0
HSD11B1L	374875	broad.mit.edu	37	19	5687578	5687578	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr19:5687578C>T	ENST00000581521.1	+	9	1042	c.567C>T	c.(565-567)ttC>ttT	p.F189F	HSD11B1L_ENST00000423665.2_Silent_p.F189F|HSD11B1L_ENST00000342970.2_Silent_p.F102F|HSD11B1L_ENST00000581893.1_Silent_p.F55F|RPL36_ENST00000579649.1_Intron|HSD11B1L_ENST00000577917.1_Silent_p.F108F|HSD11B1L_ENST00000583928.1_Silent_p.F55F|RPL36_ENST00000582380.2_Intron|HSD11B1L_ENST00000581773.1_Silent_p.F189F|HSD11B1L_ENST00000301382.4_Silent_p.F108F|HSD11B1L_ENST00000411793.2_Silent_p.F55F|HSD11B1L_ENST00000339423.2_Silent_p.F189F|RPL36_ENST00000577222.1_Intron			Q7Z5J1	DHI1L_HUMAN	hydroxysteroid (11-beta) dehydrogenase 1-like	189						extracellular region	binding|oxidoreductase activity										ACGGCTTCTTCGGCTCCCTGC	0.711000													3	13					0	0	1	0	0
KAT2B	8850	broad.mit.edu	37	3	20136888	20136888	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:20136888C>T	ENST00000263754.4	+	3	1019	c.564C>T	c.(562-564)ttC>ttT	p.F188F	KAT2B_ENST00000426228.1_3'UTR	NM_003884.4	NP_003875.3	Q92831	KAT2B_HUMAN	K(lysine) acetyltransferase 2B	188					cell cycle arrest|cellular response to insulin stimulus|chromatin remodeling|histone H3 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|negative regulation of cell proliferation|transcription initiation from RNA polymerase I promoter	Ada2/Gcn5/Ada3 transcription activator complex|chromatin remodeling complex|PCAF complex	cyclin-dependent protein kinase inhibitor activity|histone acetyltransferase activity|histone deacetylase binding|protein kinase binding|transcription coactivator activity|transcription factor binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	40						AAGTTTATTTCTATCTATTTA	0.368000													4	9					0	0	1	0	0
CLUH	23277	broad.mit.edu	37	17	2594938	2594938	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr17:2594938C>T	ENST00000570628.2	-	25	3816	c.3711G>A	c.(3709-3711)ctG>ctA	p.L1237L	CLUH_ENST00000538975.1_Silent_p.L1237L|CLUH_ENST00000435359.1_Silent_p.L1237L					clustered mitochondria (cluA/CLU1) homolog																		TAATGACGTTCAGCTGCTCCA	0.677000													6	15					0	0	1	0	0
ZNF513	130557	broad.mit.edu	37	2	27601125	27601125	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr2:27601125C>T	ENST00000323703.6	-	4	1111	c.913G>A	c.(913-915)Gaa>Aaa	p.E305K	ZNF513_ENST00000491924.1_Intron|ZNF513_ENST00000407879.1_Missense_Mutation_p.E243K	NM_144631.5	NP_653232.3	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	305					regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding			endometrium(5)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)	17	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGCAGTGGTTCTGATCCAGTC	0.637000													6	28					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	168834113	168834113	+	Nonsense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:168834113G>C	ENST00000464456.1	-	7	2183	c.983C>G	c.(982-984)tCa>tGa	p.S328*	MECOM_ENST00000468789.1_Nonsense_Mutation_p.S328*|MECOM_ENST00000460814.1_Nonsense_Mutation_p.S328*|MECOM_ENST00000392736.3_Nonsense_Mutation_p.S328*|MECOM_ENST00000494292.1_Nonsense_Mutation_p.S516*|MECOM_ENST00000433243.2_Nonsense_Mutation_p.S329*|MECOM_ENST00000264674.3_Nonsense_Mutation_p.S393*|MECOM_ENST00000472280.1_Nonsense_Mutation_p.S329*	NM_001164000.1	NP_001157472.1	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	0							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						TTCAGTACTTGATAGTCCTTT	0.448000													16	44					0	0	1	0	0
KIAA0922	23240	broad.mit.edu	37	4	154524973	154524973	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr4:154524973C>T	ENST00000409663.3	+	25	2858	c.2806C>T	c.(2806-2808)Ctc>Ttc	p.L936F	KIAA0922_ENST00000440693.1_Missense_Mutation_p.L853F|KIAA0922_ENST00000409959.3_Missense_Mutation_p.L937F	NM_015196.3	NP_056011.3	A2VDJ0	T131L_HUMAN	KIAA0922	936						integral to membrane				breast(2)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(16)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	63	all_hematologic(180;0.093)	Renal(120;0.118)				CAAGAACTTTCTCGATACATA	0.433000													8	35					0	0	1	0	0
EWSR1	2130	broad.mit.edu	37	22	29693913	29693913	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr22:29693913G>C	ENST00000397938.2	+	13	1710	c.1391G>C	c.(1390-1392)aGa>aCa	p.R464T	EWSR1_ENST00000414183.2_Missense_Mutation_p.R469T|EWSR1_ENST00000332050.6_Missense_Mutation_p.R391T|EWSR1_ENST00000332035.6_Missense_Mutation_p.R408T|EWSR1_ENST00000406548.1_Missense_Mutation_p.R463T|EWSR1_ENST00000331029.7_Missense_Mutation_p.R426T	NM_001163285.1|NM_001163286.1|NM_005243.3|NM_013986.3	NP_001156757.1|NP_001156758.1|NP_005234.1|NP_053733.2	Q01844	EWS_HUMAN	EWS RNA-binding protein 1	464	Arg/Gly/Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	calmodulin binding|nucleotide binding|RNA binding|zinc ion binding		EWSR1/ATF1(347)|EWSR1/POU5F1(10)|EWSR1/PBX1(3)|EWSR1/DDIT3(45)|EWSR1/FEV(11)|EWSR1/CREB1(44)|EWSR1/SMARCA5(2)|EWSR1/ETV4(6)|EWSR1/ERG(178)|EWSR1/ZNF384(4)|EWSR1/ETV1(7)|EWSR1/FLI1(2569)|EWSR1/NR4A3(146)|EWSR1/SP3(3)|EWSR1/PATZ1(2)|EWSR1/WT1(234)|EWSR1/NFATC2(9)	breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|liver(1)|lung(6)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						CGTGAGGGCAGAGGCATGCCA	0.483000			T	"""FLI1, ERG, ZNF278, NR4A3, FEV, ATF1, ETV1, ETV4, WT1, ZNF384, CREB1, POU5F1,  PBX1"""	"""Ewing sarcoma,  desmoplastic small round cell tumor , ALL, clear cell sarcoma, sarcoma, myoepithelioma"""								13	47					0	0	1	0	0
ENTPD8	377841	broad.mit.edu	37	9	140331139	140331139	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr9:140331139C>T	ENST00000371506.2	-	6	803	c.620G>A	c.(619-621)gGa>gAa	p.G207E	ENTPD8_ENST00000344119.2_Missense_Mutation_p.G207E|ENTPD8_ENST00000472938.1_Missense_Mutation_p.G207E	NM_001033113.1	NP_001028285.1	Q5MY95	ENTP8_HUMAN	ectonucleoside triphosphate diphosphohydrolase 8	207						integral to membrane|plasma membrane	ATP binding			biliary_tract(1)|lung(4)|prostate(1)|skin(1)	7	all_cancers(76;0.0926)			OV - Ovarian serous cystadenocarcinoma(145;0.000224)|Epithelial(140;0.000898)		GGAGGCCCCTCCCATGTCCAG	0.632000													3	5					0	0	1	0	0
TRIM63	84676	broad.mit.edu	37	1	26385055	26385055	+	Silent	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr1:26385055G>A	ENST00000374272.3	-	5	795	c.657C>T	c.(655-657)atC>atT	p.I219I		NM_032588.3	NP_115977.2	Q969Q1	TRI63_HUMAN	tripartite motif containing 63, E3 ubiquitin protein ligase	219						cytoplasm|microtubule|nucleus	ligase activity|signal transducer activity|titin binding|zinc ion binding			kidney(1)|large_intestine(1)|ovary(1)|skin(1)|stomach(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;0.000154)|all_lung(284;0.00021)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;9.15e-26)|Colorectal(126;3.16e-08)|COAD - Colon adenocarcinoma(152;1.72e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000767)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		TCTCATCCAGGATGGCATACA	0.517000													40	60					0	0	1	0	0
NECAP1	25977	broad.mit.edu	37	12	8242817	8242817	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr12:8242817G>A	ENST00000339754.5	+	3	301	c.223G>A	c.(223-225)Gaa>Aaa	p.E75K		NM_015509.3	NP_056324.2	Q8NC96	NECP1_HUMAN	NECAP endocytosis associated 1	75					endocytosis|protein transport	clathrin coated vesicle membrane|plasma membrane				cervix(1)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10				Kidney(36;0.0915)		GGCACCAGTAGAACAATATCC	0.438000													18	39					0	0	1	0	0
FAM193A	8603	broad.mit.edu	37	4	2696740	2696740	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr4:2696740G>A	ENST00000324666.5	+	15	2638	c.2287G>A	c.(2287-2289)Gag>Aag	p.E763K	FAM193A_ENST00000545951.1_Missense_Mutation_p.E763K|FAM193A_ENST00000502458.1_Missense_Mutation_p.E785K|FAM193A_ENST00000382839.3_Missense_Mutation_p.E763K|FAM193A_ENST00000505311.1_Missense_Mutation_p.E763K	NM_001256666.1	NP_001243595.1	P78312	F193A_HUMAN	family with sequence similarity 193, member A	763										NS(2)|breast(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(12)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	40						TGATGGGGACGAGAGTGCAGA	0.572000													6	10					0	0	1	0	0
TRIM63	84676	broad.mit.edu	37	1	26384977	26384977	+	Silent	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr1:26384977G>A	ENST00000374272.3	-	5	873	c.735C>T	c.(733-735)ctC>ctT	p.L245L		NM_032588.3	NP_115977.2	Q969Q1	TRI63_HUMAN	tripartite motif containing 63, E3 ubiquitin protein ligase	245						cytoplasm|microtubule|nucleus	ligase activity|signal transducer activity|titin binding|zinc ion binding			kidney(1)|large_intestine(1)|ovary(1)|skin(1)|stomach(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;0.000154)|all_lung(284;0.00021)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;9.15e-26)|Colorectal(126;3.16e-08)|COAD - Colon adenocarcinoma(152;1.72e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000767)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		ACTGCTGGATGAGGGCCTCGA	0.547000													24	61					0	0	1	0	0
PCNT	5116	broad.mit.edu	37	21	47831124	47831124	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr21:47831124G>A	ENST00000359568.5	+	28	5244	c.5137G>A	c.(5137-5139)Gag>Aag	p.E1713K	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	1713					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					CAGAAGTTCTGAGATTGAAGA	0.398000													21	36					0	0	1	0	0
METTL25	84190	broad.mit.edu	37	12	82752591	82752591	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr12:82752591G>A	ENST00000248306.3	+	1	316	c.247G>A	c.(247-249)Gag>Aag	p.E83K	METTL25_ENST00000547357.1_3'UTR	NM_032230.2	NP_115606.2			methyltransferase like 25																		AGTGGAAGCAGAGTGGGAAGC	0.682000											OREG0022008	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	17					0	0	1	0	0
TNPO1	3842	broad.mit.edu	37	5	72161422	72161422	+	Splice_Site	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr5:72161422G>A	ENST00000337273.5	+	6	888		c.e6-1		TNPO1_ENST00000447967.2_Intron|TNPO1_ENST00000506351.2_Splice_Site|TNPO1_ENST00000523768.1_Splice_Site|TNPO1_ENST00000454282.1_Splice_Site	NM_002270.3	NP_002261.3	Q92973	TNPO1_HUMAN	transportin 1						interspecies interaction between organisms|mRNA metabolic process|protein import into nucleus, translocation	cytosol|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(10)|lung(6)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	36		Lung NSC(167;0.0053)|Ovarian(174;0.0175)		OV - Ovarian serous cystadenocarcinoma(47;6.14e-54)		GTCTCTTACAGGGAGCATTTG	0.338000													5	21					0	0	1	0	0
S100A7A	338324	broad.mit.edu	37	1	153391671	153391671	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr1:153391671G>C	ENST00000368729.4	+	3	249	c.192G>C	c.(190-192)aaG>aaC	p.K64N	S100A7A_ENST00000368728.2_Missense_Mutation_p.K64N|S100A7A_ENST00000329256.2_Missense_Mutation_p.K64N	NM_176823.3	NP_789793.1	Q86SG5	S1A7A_HUMAN	S100 calcium binding protein A7A	64	EF-hand 2.					cytoplasm	calcium ion binding			cervix(1)|endometrium(3)|kidney(1)|lung(3)|prostate(1)|skin(2)|stomach(1)	12	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			AAAAGGACAAGAATGAGGATA	0.423000													9	36					0	0	1	0	0
CLEC16A	23274	broad.mit.edu	37	16	11096993	11096993	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr16:11096993G>A	ENST00000409790.1	+	11	1364	c.1134G>A	c.(1132-1134)atG>atA	p.M378I	CLEC16A_ENST00000409552.3_Missense_Mutation_p.M376I	NM_015226.2	NP_056041.1	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	378										breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						CCCTTGAGATGAACAAGCACA	0.527000													15	21					0	0	1	0	0
PLXNB1	5364	broad.mit.edu	37	3	48461413	48461413	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:48461413G>A	ENST00000358536.4	-	11	2551	c.2282C>T	c.(2281-2283)cCt>cTt	p.P761L	PLXNB1_ENST00000358459.4_Intron|PLXNB1_ENST00000456774.1_Intron|PLXNB1_ENST00000296440.6_Missense_Mutation_p.P761L|PLXNB1_ENST00000448774.2_Intron	NM_002673.4	NP_002664.2	O43157	PLXB1_HUMAN	plexin B1	761	Pro-rich.				axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GGGGCTGGGAGGGGAGGGCTC	0.657000													9	18					0	0	1	0	0
PLTP	5360	broad.mit.edu	37	20	44539852	44539852	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr20:44539852C>G	ENST00000477313.1	-	2	733	c.139G>C	c.(139-141)Gag>Cag	p.E47Q	PLTP_ENST00000354050.4_Missense_Mutation_p.E47Q|PLTP_ENST00000420868.2_Missense_Mutation_p.E47Q|PLTP_ENST00000372431.3_Missense_Mutation_p.E47Q|PLTP_ENST00000542937.1_Missense_Mutation_p.E67Q			P55058	PLTP_HUMAN	phospholipid transfer protein	47					cellular lipid metabolic process|lipid transport	extracellular region	lipid binding			endometrium(2)|kidney(2)|large_intestine(8)|lung(8)|ovary(1)	21		Myeloproliferative disorder(115;0.0122)				GTGATAGTCTCCAGCTCTTGC	0.622000													24	68					0	0	1	0	0
RAF1	5894	broad.mit.edu	37	3	12650782	12650782	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:12650782C>G	ENST00000251849.4	-	4	812	c.373G>C	c.(373-375)Gaa>Caa	p.E125Q	RAF1_ENST00000542177.1_Missense_Mutation_p.E44Q|RAF1_ENST00000442415.2_Missense_Mutation_p.E125Q	NM_002880.3	NP_002871.1	P04049	RAF1_HUMAN	v-raf-1 murine leukemia viral oncogene homolog 1	125	RBD.				activation of MAPKK activity|apoptosis|axon guidance|cell proliferation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of protein complex assembly|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of peptidyl-serine phosphorylation|Ras protein signal transduction|synaptic transmission	cytosol|mitochondrial outer membrane|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|receptor signaling protein activity		ESRP1/RAF1(4)|RAF1/DAZL(2)|SRGAP3/RAF1(6)	biliary_tract(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)	32					Sorafenib(DB00398)	ACTTGAAGTTCTTCTCCAATC	0.383000			T	SRGAP3	pilocytic astrocytoma				Noonan syndrome				22	48					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152324296	152324296	+	Nonsense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr1:152324296G>C	ENST00000388718.5	-	3	6038	c.5966C>G	c.(5965-5967)tCa>tGa	p.S1989*	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1989							calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTCATGAACTGAGGATCCTGA	0.522000													71	170					0	0	1	0	0
ATP8B1	5205	broad.mit.edu	37	18	55315746	55315746	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr18:55315746C>T	ENST00000536015.1	-	28	3849	c.3730G>A	c.(3730-3732)Gag>Aag	p.E1244K	ATP8B1_ENST00000283684.4_Missense_Mutation_p.E1244K|RP11-35G9.3_ENST00000592201.1_RNA|RP11-35G9.3_ENST00000599199.1_RNA|RP11-35G9.5_ENST00000588925.1_RNA|RP11-35G9.3_ENST00000591854.1_RNA	NM_005603.4	NP_005594	O43520	AT8B1_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 1	1244					ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(19)|ovary(3)|prostate(1)	53		Colorectal(73;0.229)				CGCCTGTACTCCGCGGTGCCA	0.612000													14	50					0	0	1	0	0
SCGB1C1	147199	broad.mit.edu	37	11	193799	193799	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr11:193799G>T	ENST00000342878.2	+	2	163	c.143G>T	c.(142-144)gGg>gTg	p.G48V	BET1L_ENST00000410108.1_Intron	NM_145651.2	NP_663626.2	Q8TD33	SG1C1_HUMAN	secretoglobin, family 1C, member 1	48						extracellular region	binding			endometrium(1)|liver(2)|lung(1)|skin(1)	5		all_cancers(49;1.58e-09)|all_epithelial(84;2.71e-06)|Breast(177;0.000162)|Ovarian(85;0.000626)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;3.95e-27)|Epithelial(43;2.66e-26)|OV - Ovarian serous cystadenocarcinoma(40;5.55e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.105)|LUSC - Lung squamous cell carcinoma(625;0.122)		CTCTATGAGGGGACCTTGGGC	0.542000													6	43					0.00198382	0.00202141	1	1	0
PKMYT1	9088	broad.mit.edu	37	16	3024407	3024407	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr16:3024407C>T	ENST00000431515.2	-	6	1376	c.991G>A	c.(991-993)Gag>Aag	p.E331K	PKMYT1_ENST00000573944.1_Missense_Mutation_p.E322K|PKMYT1_ENST00000262300.8_Missense_Mutation_p.E331K|PKMYT1_ENST00000574385.1_Missense_Mutation_p.E322K|PKMYT1_ENST00000440027.2_Missense_Mutation_p.E331K|PKMYT1_ENST00000574730.1_Missense_Mutation_p.E262K			Q99640	PMYT1_HUMAN	protein kinase, membrane associated tyrosine/threonine 1	331	Protein kinase.				G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of mitosis	endoplasmic reticulum membrane|Golgi membrane|membrane fraction|nucleoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(1)|endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	10						GAACGCAGCTCGGAAGACAGA	0.662000													8	16					0	0	1	0	0
PEAK1	79834	broad.mit.edu	37	15	77472557	77472557	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr15:77472557G>A	ENST00000560626.2	-	4	2187	c.1712C>T	c.(1711-1713)aCa>aTa	p.T571I	PEAK1_ENST00000558305.1_Missense_Mutation_p.T571I|PEAK1_ENST00000312493.4_Missense_Mutation_p.T571I			Q9H792	PEAK1_HUMAN	pseudopodium-enriched atypical kinase 1	571					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding										TGTGGGTGATGTAGGTGCTGA	0.383000													30	110					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38951129	38951129	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr19:38951129C>T	ENST00000355481.4	+	20	2606	c.2475C>T	c.(2473-2475)atC>atT	p.I825I	RYR1_ENST00000359596.3_Silent_p.I825I|RYR1_ENST00000360985.3_Silent_p.I825I	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	825					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TTGAACCCATCAAGGAGTATC	0.637000													29	74					0	0	1	0	0
TMEM131	23505	broad.mit.edu	37	2	98375509	98375509	+	Silent	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr2:98375509G>A	ENST00000186436.5	-	40	5442	c.5214C>T	c.(5212-5214)ttC>ttT	p.F1738F		NM_015348.1	NP_056163.1	Q92545	TM131_HUMAN	transmembrane protein 131	1738	Ser-rich.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(4)|prostate(1)|skin(1)|stomach(1)	57						CGAGTTTGCTGAAAACTTCTG	0.463000													24	49					0	0	1	0	0
KARS	3735	broad.mit.edu	37	16	75675551	75675551	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr16:75675551C>G	ENST00000319410.5	-	3	338	c.217G>C	c.(217-219)Gag>Cag	p.E73Q	KARS_ENST00000568378.1_Intron|KARS_ENST00000302445.3_Missense_Mutation_p.E45Q	NM_001130089.1	NP_001123561.1	Q15046	SYK_HUMAN	lysyl-tRNA synthetase	45					interspecies interaction between organisms|lysyl-tRNA aminoacylation|tRNA processing	cytosol|extracellular region|mitochondrial matrix|nucleus|plasma membrane|soluble fraction	ATP binding|lysine-tRNA ligase activity|metal ion binding|tRNA binding			kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	18					L-Lysine(DB00123)	AGCTGTTTCTCACTGAGCTCT	0.502000													18	33					0	0	1	0	0
STX16	8675	broad.mit.edu	37	20	57242588	57242588	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr20:57242588G>C	ENST00000371141.4	+	3	911	c.187G>C	c.(187-189)Gat>Cat	p.D63H	STX16_ENST00000371132.4_Missense_Mutation_p.D42H|STX16-NPEPL1_ENST00000530122.1_Missense_Mutation_p.D63H|STX16_ENST00000355957.5_Missense_Mutation_p.D46H|STX16_ENST00000358029.4_Missense_Mutation_p.D59H|STX16_ENST00000496003.1_3'UTR|STX16_ENST00000359617.4_Missense_Mutation_p.D10H|STX16_ENST00000361770.5_Missense_Mutation_p.D46H|STX16_ENST00000361830.3_Missense_Mutation_p.D63H	NM_001001433.2	NP_001001433.1	O14662	STX16_HUMAN	syntaxin 16	63					intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde transport, endosome to Golgi	Golgi membrane|integral to membrane|microsome|SNARE complex	SNAP receptor activity			breast(1)|cervix(1)|large_intestine(3)|lung(9)|ovary(1)|pancreas(1)|urinary_tract(1)	17	all_lung(29;0.0175)		BRCA - Breast invasive adenocarcinoma(13;3.73e-09)|Epithelial(14;8.54e-06)|all cancers(14;6.89e-05)			CATCAGCTTAGATCCAGAAGC	0.413000													7	31					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183673033	183673033	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr4:183673033G>A	ENST00000511685.1	+	20	3833	c.3710G>A	c.(3709-3711)aGa>aAa	p.R1237K	TENM3_ENST00000406950.2_Missense_Mutation_p.R1237K|TENM3_ENST00000502950.1_3'UTR					teneurin transmembrane protein 3									p.R1237T(1)									AACACCCGCAGAATTTATCGC	0.498000													23	63					0	0	1	0	0
KIAA1522	57648	broad.mit.edu	37	1	33235534	33235534	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr1:33235534G>A	ENST00000401073.2	+	6	824	c.754G>A	c.(754-756)Gat>Aat	p.D252N	KIAA1522_ENST00000373481.3_Missense_Mutation_p.D204N|KIAA1522_ENST00000373480.1_Missense_Mutation_p.D193N|KIAA1522_ENST00000294521.3_Intron	NM_020888.2	NP_065939.2	Q9P206	K1522_HUMAN	KIAA1522	193										breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				TGGTGCACGGGATGCCGTACG	0.716000													10	21					0	0	1	0	0
AOC1	26	broad.mit.edu	37	7	150555940	150555940	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr7:150555940C>G	ENST00000493429.1	+	5	2244	c.1660C>G	c.(1660-1662)Ctg>Gtg	p.L554V	AOC1_ENST00000467291.1_Missense_Mutation_p.L554V|AOC1_ENST00000480582.1_3'UTR|AOC1_ENST00000360937.4_Missense_Mutation_p.L554V|AOC1_ENST00000416793.2_Missense_Mutation_p.L554V					amine oxidase, copper containing 1																		CCAGCCAACTCTGGAGCAGAC	0.582000													5	24					0	0	1	0	0
PALB2	79728	broad.mit.edu	37	16	23641638	23641638	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr16:23641638G>A	ENST00000261584.4	-	5	1989	c.1837C>T	c.(1837-1839)Cag>Tag	p.Q613*		NM_024675.3	NP_078951.2	Q86YC2	PALB2_HUMAN	partner and localizer of BRCA2	613					double-strand break repair via homologous recombination	nucleoplasm	DNA binding|protein binding			breast(5)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(21)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(3)	55				GBM - Glioblastoma multiforme(48;0.0167)		TCAGGTAACTGAAAGTCTGTG	0.403000			"""F, N, Mis"""			"""Wilms tumor, medulloblastoma, AML ,breast"""		Involved in tolerance or repair of DNA crosslinks					12	33					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151845353	151845353	+	Silent	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr7:151845353G>A	ENST00000355193.2	-	53	14048	c.13830C>T	c.(13828-13830)ctC>ctT	p.L4610L	KMT2C_ENST00000262189.6_Silent_p.L4553L					lysine (K)-specific methyltransferase 2C																		TGTGGAAGATGAGGCTACCCA	0.532000													11	28					0	0	1	0	0
GPR88	54112	broad.mit.edu	37	1	101005449	101005449	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr1:101005449C>T	ENST00000315033.4	+	2	1366	c.927C>T	c.(925-927)ttC>ttT	p.F309F		NM_022049.2	NP_071332.2	Q9GZN0	GPR88_HUMAN	G protein-coupled receptor 88	309						integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(2)|skin(1)	3		all_epithelial(167;1.19e-05)|all_lung(203;0.00159)|Lung NSC(277;0.00171)		Epithelial(280;0.0372)|all cancers(265;0.0558)|COAD - Colon adenocarcinoma(174;0.141)|Colorectal(144;0.156)|Lung(183;0.189)		CCAGCGGCTTCTCGCTGCCGG	0.697000													5	12					0	0	1	0	0
NR2C2	7182	broad.mit.edu	37	3	15073965	15073965	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:15073965C>G	ENST00000425241.1	+	10	1552	c.1190C>G	c.(1189-1191)tCa>tGa	p.S397*	NR2C2_ENST00000406272.2_Nonsense_Mutation_p.S397*|NR2C2_ENST00000478572.1_3'UTR|NR2C2_ENST00000393102.3_Nonsense_Mutation_p.S397*|NR2C2_ENST00000323373.6_Nonsense_Mutation_p.S416*			P49116	NR2C2_HUMAN	nuclear receptor subfamily 2, group C, member 2	397	Ligand-binding (By similarity).				cell differentiation|nervous system development|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|spermatogenesis	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			breast(1)|endometrium(2)|large_intestine(5)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						CTTTTCCTCTCAATGCACTGG	0.542000													15	52					0	0	1	0	0
C3orf67	200844	broad.mit.edu	37	3	58849499	58849499	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:58849499C>G	ENST00000472469.1	-	11	1562	c.724G>C	c.(724-726)Gag>Cag	p.E242Q	C3orf67_ENST00000295966.7_Missense_Mutation_p.E335Q|RP11-147N17.1_ENST00000463703.1_RNA|RP11-147N17.1_ENST00000482372.1_RNA|RP11-147N17.1_ENST00000493123.1_RNA|C3orf67_ENST00000482387.1_Missense_Mutation_p.E335Q|RP11-147N17.1_ENST00000492031.1_RNA			Q6ZVT6	CC067_HUMAN	chromosome 3 open reading frame 67	335										endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(3)|prostate(2)|skin(1)	19		all_cancers(2;0.000156)|all_epithelial(2;0.000493)|Breast(2;0.00446)|all_lung(2;0.074)|Lung NSC(2;0.248)		BRCA - Breast invasive adenocarcinoma(55;5.93e-06)|Kidney(10;0.00155)|KIRC - Kidney renal clear cell carcinoma(10;0.00172)|OV - Ovarian serous cystadenocarcinoma(275;0.23)		TGTTCACTCTCTTTGCTGGCT	0.483000													18	35					0	0	1	0	0
KIAA2018	205717	broad.mit.edu	37	3	113376961	113376961	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:113376961C>A	ENST00000316407.4	-	7	3978	c.3568G>T	c.(3568-3570)Gaa>Taa	p.E1190*	KIAA2018_ENST00000478658.1_Nonsense_Mutation_p.E1190*|KIAA2018_ENST00000491165.1_Intron	NM_001009899.2	NP_001009899.2	Q68DE3	K2018_HUMAN	KIAA2018	1190					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(30)|ovary(8)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	80						GGTGTTGCTTCTGCCTGTCCT	0.418000													7	30					8.12818e-05	8.38815e-05	1	1	0
RFX4	5992	broad.mit.edu	37	12	107144526	107144526	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr12:107144526C>G	ENST00000392842.1	+	17	2304	c.1890C>G	c.(1888-1890)atC>atG	p.I630M	RP11-144F15.1_ENST00000551505.1_Intron|RFX4_ENST00000229387.5_Missense_Mutation_p.I536M|RFX4_ENST00000357881.4_Missense_Mutation_p.I639M	NM_213594.2	NP_998759.1	Q33E94	RFX4_HUMAN	regulatory factor X, 4 (influences HLA class II expression)	630					transcription, DNA-dependent	nucleus	DNA binding			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(20)|pancreas(1)|upper_aerodigestive_tract(1)	35						ACACAGCTATCTCTGGGCCAC	0.537000													28	97					0	0	1	0	0
C2orf78	388960	broad.mit.edu	37	2	74041300	74041300	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr2:74041300C>G	ENST00000409561.1	+	2	915	c.794C>G	c.(793-795)tCt>tGt	p.S265C		NM_001080474.1	NP_001073943.1	A6NCI8	CB078_HUMAN	chromosome 2 open reading frame 78	265										cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|soft_tissue(1)|urinary_tract(1)	34						GTCTCTACTTCTGGGATGTAT	0.453000													17	45					0	0	1	0	0
MED21	9412	broad.mit.edu	37	12	27175537	27175537	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr12:27175537C>T	ENST00000282892.3	+	1	55	c.25C>T	c.(25-27)Cag>Tag	p.Q9*	MED21_ENST00000546323.1_Nonsense_Mutation_p.Q9*|MED21_ENST00000536503.1_3'UTR	NM_001271811.1|NM_004264.3	NP_001258740.1|NP_004255.2	Q13503	MED21_HUMAN	mediator complex subunit 21	9					positive regulation of transcription from RNA polymerase II promoter	mediator complex	DNA-directed RNA polymerase activity|transcription coactivator activity					Colorectal(261;0.0847)					CACGCAGCTTCAGGACGCTGT	0.542000													29	29					0	0	1	0	0
GLTSCR1L	23506	broad.mit.edu	37	6	42823610	42823610	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr6:42823610G>C	ENST00000314073.5	+	9	2239	c.2063G>C	c.(2062-2064)gGa>gCa	p.G688A	GLTSCR1L_ENST00000394168.1_Missense_Mutation_p.G688A					GLTSCR1-like																		AGTCATTCGGGAGGACAAAAA	0.378000													19	67					0	0	1	0	0
TM4SF19	116211	broad.mit.edu	37	3	196054402	196054402	+	Silent	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:196054402C>G	ENST00000446879.1	-	2	185	c.60G>C	c.(58-60)ctG>ctC	p.L20L	TM4SF19_ENST00000273695.3_Silent_p.L20L|TM4SF19_ENST00000454715.1_Silent_p.L20L|TM4SF19_ENST00000442633.1_Silent_p.L20L			Q96DZ7	T4S19_HUMAN	transmembrane 4 L six family member 19	20						integral to membrane				endometrium(2)|kidney(2)|large_intestine(3)|lung(5)	12	all_cancers(143;1.19e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;3.94e-24)|all cancers(36;4.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.53e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00314)		TCCCAAGGCTCAGTCCCAGGA	0.607000													24	68					0	0	1	0	0
C2orf71	388939	broad.mit.edu	37	2	29293657	29293657	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr2:29293657C>T	ENST00000331664.5	-	1	3470	c.3471G>A	c.(3469-3471)ggG>ggA	p.G1157G		NM_001029883.2	NP_001025054.1	A6NGG8	CB071_HUMAN	chromosome 2 open reading frame 71	1157					response to stimulus|visual perception	photoreceptor outer segment				NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						CTGCTGGGTTCCCGAGAGGGC	0.622000													13	40					0	0	1	0	0
PRPF40A	55660	broad.mit.edu	37	2	153519627	153519627	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr2:153519627C>T	ENST00000410080.1	-	20	2689	c.2148G>A	c.(2146-2148)atG>atA	p.M716I		NM_017892.3	NP_060362.3	O75400	PR40A_HUMAN	PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)	743					mRNA processing|RNA splicing	nuclear matrix|nuclear speck	protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|prostate(1)|urinary_tract(1)	21						CTTTTCGTTTCATCTTCCGAG	0.338000													8	22					0	0	1	0	0
NCAPD3	23310	broad.mit.edu	37	11	134022913	134022913	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr11:134022913G>A	ENST00000534548.2	-	35	4487	c.4423C>T	c.(4423-4425)Ccc>Tcc	p.P1475S	NCAPD3_ENST00000526787.2_Intron	NM_015261.2	NP_056076.1	P42695	CNDD3_HUMAN	non-SMC condensin II complex, subunit D3	1475					cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)		TTCCTGGCGGGAGACCGCACA	0.557000													21	66					0	0	1	0	0
ZMYM4	9202	broad.mit.edu	37	1	35853094	35853094	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr1:35853094G>A	ENST00000314607.6	+	13	2232	c.2152G>A	c.(2152-2154)Gaa>Aaa	p.E718K	ZMYM4_ENST00000373297.2_Missense_Mutation_p.E629K	NM_005095.2	NP_005086.2	Q5VZL5	ZMYM4_HUMAN	zinc finger, MYM-type 4	718					multicellular organismal development		DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(16)|ovary(2)|prostate(3)|skin(2)	54		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TTGTTCTGATGAATATAAGAA	0.313000													9	21					0	0	1	0	0
DAGLA	747	broad.mit.edu	37	11	61511592	61511592	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr11:61511592C>T	ENST00000257215.5	+	20	2876	c.2760C>T	c.(2758-2760)ctC>ctT	p.L920L		NM_006133.2	NP_006124.1	Q9Y4D2	DGLA_HUMAN	diacylglycerol lipase, alpha	920					cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|liver(2)|lung(17)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(4)	43				READ - Rectum adenocarcinoma(4;0.219)		TCGACAGCCTCTTCAACCTGG	0.662000													12	38					0	0	1	0	0
DHX15	1665	broad.mit.edu	37	4	24585973	24585973	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr4:24585973G>C	ENST00000336812.4	-	1	200	c.44C>G	c.(43-45)tCt>tGt	p.S15C		NM_001358.2	NP_001349.2	O43143	DHX15_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 15	15					mRNA processing	U12-type spliceosomal complex	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	30		Breast(46;0.0503)				CTTCTTGCCAGAGGGGTAATC	0.652000													7	8					0	0	1	0	0
LRRIQ4	344657	broad.mit.edu	37	3	169540564	169540564	+	Silent	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:169540564C>G	ENST00000340806.6	+	1	855	c.855C>G	c.(853-855)ctC>ctG	p.L285L		NM_001080460.1	NP_001073929.1	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	285										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	30						TGCACCTGCTCTACCTGGGAA	0.627000													5	20					0	0	1	0	0
DUSP6	1848	broad.mit.edu	37	12	89744761	89744761	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr12:89744761C>G	ENST00000279488.7	-	2	1673	c.442G>C	c.(442-444)Gag>Cag	p.E148Q	DUSP6_ENST00000547140.1_5'UTR|DUSP6_ENST00000308385.6_Intron|DUSP6_ENST00000547291.1_Missense_Mutation_p.E23Q	NM_001946.2	NP_001937.2	Q16828	DUS6_HUMAN	dual specificity phosphatase 6	148	Rhodanese.				dorsal/ventral pattern formation|inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|nerve growth factor receptor signaling pathway|positive regulation of apoptosis|regulation of endodermal cell fate specification|regulation of fibroblast growth factor receptor signaling pathway|regulation of heart growth|response to nitrosative stress|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			large_intestine(5)|lung(8)|skin(2)|urinary_tract(1)	16						AGATTGGTCTCGCAATGCAGG	0.562000													6	4					0	0	1	0	0
KIAA2018	205717	broad.mit.edu	37	3	113378598	113378598	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:113378598G>A	ENST00000316407.4	-	7	2341	c.1931C>T	c.(1930-1932)tCa>tTa	p.S644L	KIAA2018_ENST00000478658.1_Missense_Mutation_p.S644L|KIAA2018_ENST00000491165.1_Intron	NM_001009899.2	NP_001009899.2	Q68DE3	K2018_HUMAN	KIAA2018	644					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	p.S644L(1)		NS(1)|breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(30)|ovary(8)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	80						GTTAGACGCTGATAAAGATGA	0.393000													36	92					0	0	1	0	0
GDF5	8200	broad.mit.edu	37	20	34022151	34022151	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr20:34022151G>C	ENST00000374372.1	-	4	1565	c.1062C>G	c.(1060-1062)ttC>ttG	p.F354L	GDF5OS_ENST00000374375.1_Missense_Mutation_p.K65N|GDF5_ENST00000374369.3_Missense_Mutation_p.F354L			P43026	GDF5_HUMAN	growth differentiation factor 5	354					cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(9)|skin(3)	26	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)			TCTCATTAAAGAACAGGTCCC	0.637000													24	40					0	0	1	0	0
AKR1E2	83592	broad.mit.edu	37	10	4884636	4884636	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr10:4884636G>T	ENST00000298375.7	+	8	848	c.777G>T	c.(775-777)caG>caT	p.Q259H	AKR1E2_ENST00000334019.4_Missense_Mutation_p.Q202H|AKR1E2_ENST00000532248.1_Missense_Mutation_p.Q202H|AKR1E2_ENST00000345253.5_Missense_Mutation_p.Q161H|AKR1E2_ENST00000525281.1_3'UTR	NM_001040177.2	NP_001035267.1	Q96JD6	AKCL2_HUMAN	aldo-keto reductase family 1, member E2	259						cytoplasm	1,5-anhydro-D-fructose reductase activity			NS(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(9)	15						TTCAAATCCAGAGGAATGTGA	0.383000													9	39					0.000274275	0.000281845	1	1	0
S1PR1	1901	broad.mit.edu	37	1	101704934	101704934	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr1:101704934G>A	ENST00000305352.6	+	2	769	c.394G>A	c.(394-396)Gtg>Atg	p.V132M	S1PR1_ENST00000475821.1_3'UTR	NM_001400.4	NP_001391.2	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	132					cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|large_intestine(7)|lung(23)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	43						GTCAGCCTCCGTGTTCAGTCT	0.542000											OREG0013620	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	44					0	0	1	0	0
PEAK1	79834	broad.mit.edu	37	15	77471169	77471169	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr15:77471169G>A	ENST00000560626.2	-	4	3575	c.3100C>T	c.(3100-3102)Cat>Tat	p.H1034Y	PEAK1_ENST00000558305.1_Missense_Mutation_p.H1034Y|PEAK1_ENST00000312493.4_Missense_Mutation_p.H1034Y			Q9H792	PEAK1_HUMAN	pseudopodium-enriched atypical kinase 1	1034					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding										GGAGAAGAATGACTCCTCTTC	0.413000													7	18					0	0	1	0	0
ITGAV	3685	broad.mit.edu	37	2	187506201	187506201	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr2:187506201C>T	ENST00000261023.3	+	12	1319	c.1045C>T	c.(1045-1047)Cta>Tta	p.L349L	ITGAV_ENST00000374907.3_Silent_p.L313L|ITGAV_ENST00000433736.2_Silent_p.L303L|AC017101.10_ENST00000453665.1_RNA	NM_002210.3	NP_002201	P06756	ITAV_HUMAN	integrin, alpha V	349					angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		CTCAGTGTCTCTACAGAGAGC	0.498000													45	100					0	0	1	0	0
ACTA2	59	broad.mit.edu	37	10	90699336	90699336	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr10:90699336C>G	ENST00000458208.1	-	7	1210	c.736G>C	c.(736-738)Gat>Cat	p.D246H	STAMBPL1_ENST00000371927.3_Intron|ACTA2_ENST00000224784.6_Missense_Mutation_p.D246H|ACTA2-AS1_ENST00000596007.1_RNA|ACTA2-AS1_ENST00000437930.4_RNA	NM_001141945.1	NP_001135417.1	P62736	ACTA_HUMAN	actin, alpha 2, smooth muscle, aorta	246					response to virus	cytosol	ATP binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|skin(1)|urinary_tract(2)	17		Colorectal(252;0.0161)		Colorectal(12;0.000123)|COAD - Colon adenocarcinoma(12;0.00018)		ACTTGCCCATCAGGCAACTCG	0.512000													10	42					0	0	1	0	0
UBALD1	124402	broad.mit.edu	37	16	4664715	4664715	+	Silent	SNP	C	C	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr16:4664715C>A	ENST00000590965.1	-	1	160	c.84G>T	c.(82-84)gcG>gcT	p.A28A	UBALD1_ENST00000591897.1_Intron|UBALD1_ENST00000591401.1_Silent_p.A28A|UBALD1_ENST00000587615.1_Silent_p.A28A|UBALD1_ENST00000587649.1_Silent_p.A28A|UBALD1_ENST00000283474.7_Silent_p.A28A					UBA-like domain containing 1																		GCAGTTGCTTCGCCTGGTCGG	0.731000													6	19					3.59834e-05	3.72932e-05	1	1	0
NR5A2	2494	broad.mit.edu	37	1	200017851	200017851	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr1:200017851C>G	ENST00000367362.3	+	5	1261	c.1015C>G	c.(1015-1017)Ctg>Gtg	p.L339V	NR5A2_ENST00000544748.1_Missense_Mutation_p.L267V|NR5A2_ENST00000236914.3_Missense_Mutation_p.L293V	NM_001276464.1|NM_205860.1	NP_001263393.1|NP_995582.1	O00482	NR5A2_HUMAN	nuclear receptor subfamily 5, group A, member 2	339					embryo development|positive regulation of viral genome replication|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	lipid binding|protein binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(15)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	31	Prostate(682;0.19)					GCACGAAAAGCTGAGCACCTT	0.468000													20	59					0	0	1	0	0
KDM6A	7403	broad.mit.edu	37	X	44928966	44928966	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chrX:44928966C>G	ENST00000377967.4	+	17	2107	c.2066C>G	c.(2065-2067)tCa>tGa	p.S689*	KDM6A_ENST00000382899.4_Nonsense_Mutation_p.S696*|KDM6A_ENST00000536777.1_Nonsense_Mutation_p.S644*|KDM6A_ENST00000543216.1_Nonsense_Mutation_p.S610*	NM_021140.2	NP_066963.2	O15550	KDM6A_HUMAN	lysine (K)-specific demethylase 6A	689					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0?(6)		NS(1)|breast(7)|central_nervous_system(27)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(24)|kidney(24)|large_intestine(9)|liver(1)|lung(21)|oesophagus(11)|pancreas(2)|prostate(5)|skin(1)|soft_tissue(1)|urinary_tract(29)	170						CCTAGCAATTCAGTAACACAG	0.537000			"""D, N, F, S"""		"""renal, oesophageal SCC, MM"""								8	6					0	0	1	0	0
C5orf56	441108	broad.mit.edu	37	5	131785348	131785348	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr5:131785348G>C	ENST00000337752.2	+	3	186	c.55G>C	c.(55-57)Gag>Cag	p.E19Q	C5orf56_ENST00000407797.1_Missense_Mutation_p.E19Q|C5orf56_ENST00000378947.3_Missense_Mutation_p.E19Q|C5orf56_ENST00000378953.4_Missense_Mutation_p.E19Q			Q8N8D9	CE056_HUMAN	chromosome 5 open reading frame 56	19										breast(1)|endometrium(1)|large_intestine(1)|lung(3)	6						GCAGGTGCCAGAGTTTGTAGC	0.463000													9	19					0	0	1	0	0
GTPBP8	29083	broad.mit.edu	37	3	112710162	112710162	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:112710162C>T	ENST00000383677.3	+	1	331	c.316C>T	c.(316-318)Ccg>Tcg	p.P106S	GTPBP8_ENST00000383678.2_Missense_Mutation_p.P106S	NM_138485.1	NP_612494.1	Q8N3Z3	GTPB8_HUMAN	GTP-binding protein 8 (putative)	106					barrier septum formation		GTP binding			kidney(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	6						CGACCACGCCCCGGACCTTCC	0.677000													11	23					0	0	1	0	0
FBXW4	6468	broad.mit.edu	37	10	103433334	103433334	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr10:103433334C>T	ENST00000331272.7	-	3	1071	c.453G>A	c.(451-453)ttG>ttA	p.L151L		NM_022039.3	NP_071322.1	P57775	FBXW4_HUMAN	F-box and WD repeat domain containing 4	151					ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	ubiquitin ligase complex				breast(3)|endometrium(2)|large_intestine(4)|lung(4)|skin(1)|stomach(1)	15		Colorectal(252;0.123)		Epithelial(162;4.35e-08)|all cancers(201;1.92e-06)		GCCGACGATTCAAGCTGGCAC	0.517000													35	79					0	0	1	0	0
OTUD4	54726	broad.mit.edu	37	4	146059592	146059592	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr4:146059592G>C	ENST00000454497.2	-	21	2277	c.2140C>G	c.(2140-2142)Caa>Gaa	p.Q714E	OTUD4_ENST00000455611.2_Intron|OTUD4_ENST00000447906.2_Missense_Mutation_p.Q779E	NM_001102653.1	NP_001096123.1	Q01804	OTUD4_HUMAN	OTU domain containing 4	778							protein binding			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(10)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33	all_hematologic(180;0.151)					TGTGGCATTTGACCATTAACA	0.488000													14	50					0	0	1	0	0
KCNJ2	3759	broad.mit.edu	37	17	68171399	68171399	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr17:68171399C>A	ENST00000243457.3	+	2	602	c.219C>A	c.(217-219)ttC>ttA	p.F73L	KCNJ2_ENST00000535240.1_Missense_Mutation_p.F73L	NM_000891.2	NP_000882.1	P63252	IRK2_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 2	73					synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(13)|skin(1)|urinary_tract(1)	25	Breast(10;1.64e-08)					CAGACATCTTCACCACGTGTG	0.507000													12	50					7.03913e-09	7.47135e-09	1	1	0
GJB2	2706	broad.mit.edu	37	13	20763647	20763647	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr13:20763647A>G	ENST00000382844.1	-	1	272	c.74T>C	c.(73-75)cTc>cCc	p.L25P	GJB2_ENST00000382848.4_Missense_Mutation_p.L25P			P29033	CXB2_HUMAN	gap junction protein, beta 2, 26kDa	25					cell-cell signaling|cellular membrane organization|gap junction assembly|sensory perception of sound|transport	connexon complex|ER-Golgi intermediate compartment|integral to membrane				breast(1)|endometrium(2)|large_intestine(1)|lung(2)|skin(1)	7		all_cancers(29;3.95e-22)|all_epithelial(30;2.36e-19)|all_lung(29;2.27e-18)|Lung SC(185;0.0257)|Ovarian(182;0.0822)		all cancers(112;0.000435)|Epithelial(112;0.000722)|OV - Ovarian serous cystadenocarcinoma(117;0.0096)|Lung(94;0.0236)|LUSC - Lung squamous cell carcinoma(192;0.0738)		GAGGACGGTGAGCCAGATCTT	0.547000									Keratitis, Ichthyosis and Deafness syndrome		OREG0022282	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	65					0	0	1	0	0
MICALL2	79778	broad.mit.edu	37	7	1480271	1480271	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr7:1480271C>G	ENST00000297508.7	-	8	1936	c.1761G>C	c.(1759-1761)tgG>tgC	p.W587C	MICALL2_ENST00000405088.4_Missense_Mutation_p.W375C	NM_182924.3	NP_891554.1	Q8IY33	MILK2_HUMAN	MICAL-like 2	587						cytoplasm|cytoskeleton	zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(2)|lung(8)|ovary(2)|skin(2)	19		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;6.01e-15)		GATTCGCTCTCCATCCTGCCG	0.617000													17	38					0	0	1	0	0
CLDN16	10686	broad.mit.edu	37	3	190126160	190126160	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:190126160C>G	ENST00000264734.2	+	4	898	c.650C>G	c.(649-651)tCt>tGt	p.S217C	CLDN16_ENST00000456423.1_Intron	NM_006580.3	NP_006571.1	Q9Y5I7	CLD16_HUMAN	claudin 16	217					calcium-independent cell-cell adhesion|cellular metal ion homeostasis|excretion	integral to membrane|tight junction	identical protein binding|magnesium ion transmembrane transporter activity|structural molecule activity			breast(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|skin(1)	19	all_cancers(143;3.61e-10)|Ovarian(172;0.0991)		Lung(62;2.23e-05)|LUSC - Lung squamous cell carcinoma(58;3.15e-05)	GBM - Glioblastoma multiforme(93;0.018)		GTGGAACGTTCTACTTTGGTT	0.433000													39	115					0	0	1	0	0
PPP1R26	9858	broad.mit.edu	37	9	138378017	138378017	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr9:138378017G>A	ENST00000356818.2	+	4	2210	c.1661G>A	c.(1660-1662)aGa>aAa	p.R554K	PPP1R26_ENST00000401470.3_Missense_Mutation_p.R554K|PPP1R26_ENST00000604351.1_Missense_Mutation_p.R554K|PPP1R26_ENST00000605660.1_Missense_Mutation_p.R554K|PPP1R26_ENST00000602993.1_Intron|PPP1R26_ENST00000605286.1_Missense_Mutation_p.R554K	NM_014811.3	NP_055626.3	Q5T8A7	K0649_HUMAN	protein phosphatase 1, regulatory subunit 26	554						nucleolus	protein binding										TTGCTGGCCAGAGGTGAGAGC	0.607000													69	63					0	0	1	0	0
GSTA5	221357	broad.mit.edu	37	6	52701150	52701150	+	Silent	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr6:52701150G>A	ENST00000370989.2	-	3	185	c.156C>T	c.(154-156)ttC>ttT	p.F52F	GSTA5_ENST00000284562.2_Silent_p.F52F|GSTA5_ENST00000475052.1_Intron			Q7RTV2	GSTA5_HUMAN	glutathione S-transferase alpha 5		GST N-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			endometrium(3)|large_intestine(2)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	Lung NSC(77;0.0912)				Glutathione(DB00143)	GTACTTGCTGGAACAGCAAAC	0.403000													11	53					0	0	1	0	0
RNF123	63891	broad.mit.edu	37	3	49743429	49743429	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:49743429C>T	ENST00000327697.6	+	25	2463	c.2319C>T	c.(2317-2319)tcC>tcT	p.S773S	RNF123_ENST00000432042.1_Silent_p.S627S	NM_022064.3	NP_071347.2	Q5XPI4	RN123_HUMAN	ring finger protein 123	773						cytoplasm	ligase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		TGGGTGTCTCCGATGATGTCA	0.587000													15	56					0	0	1	0	0
TMEM201	199953	broad.mit.edu	37	1	9661438	9661438	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr1:9661438G>C	ENST00000340305.5	+	5	891	c.882G>C	c.(880-882)caG>caC	p.Q294H	TMEM201_ENST00000377376.4_Missense_Mutation_p.Q294H|TMEM201_ENST00000340381.6_Missense_Mutation_p.Q294H	NM_001010866.3	NP_001010866.1	Q5SNT2	TM201_HUMAN	transmembrane protein 201	294						integral to membrane|nuclear inner membrane				lung(3)|upper_aerodigestive_tract(1)	4	all_lung(157;0.222)	all_epithelial(116;2.09e-14)|Renal(390;0.000469)|all_lung(118;0.000521)|Lung NSC(185;0.000744)|Colorectal(325;0.0062)|Breast(348;0.0157)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.5e-08)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|STAD - Stomach adenocarcinoma(132;0.00345)|READ - Rectum adenocarcinoma(331;0.0419)		CCTTTGGGCAGAGCCACCAGA	0.682000													12	62					0	0	1	0	0
BBS2	583	broad.mit.edu	37	16	56548567	56548567	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr16:56548567C>T	ENST00000245157.5	-	2	563	c.143G>A	c.(142-144)cGg>cAg	p.R48Q	BBS2_ENST00000568104.1_Missense_Mutation_p.R48Q	NM_031885.3	NP_114091	Q9BXC9	BBS2_HUMAN	Bardet-Biedl syndrome 2	48					adult behavior|brain morphogenesis|cerebral cortex development|cilium morphogenesis|fat cell differentiation|hippocampus development|melanosome transport|negative regulation of multicellular organism growth|photoreceptor cell maintenance|protein localization to organelle|regulation of cilium beat frequency involved in ciliary motility|sperm axoneme assembly|striatum development	BBSome|cilium membrane|microtubule basal body|motile cilium	protein binding			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|skin(3)	26						ATGCTGGTTCCGTGTATGAGG	0.378000									Bardet-Biedl syndrome				7	19					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10071088	10071088	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr19:10071088C>T	ENST00000264828.3	-	67	5322	c.5237G>A	c.(5236-5238)tGa>tAa	p.*1746*		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	0					collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			CGGACACTCTCAGCTGCTGAA	0.572000													15	25					0	0	1	0	0
UNG	7374	broad.mit.edu	37	12	109536371	109536371	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr12:109536371C>T	ENST00000336865.2	+	1	449	c.240C>T	c.(238-240)aaC>aaT	p.N80N	UNG_ENST00000242576.2_Silent_p.N89N	NM_003362.3	NP_003353.1	P13051	UNG_HUMAN	uracil-DNA glycosylase	89					base-excision repair|interspecies interaction between organisms	mitochondrion|nucleus	protein binding|uracil DNA N-glycosylase activity			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(4)|ovary(1)	9						CGGCCCGCAACGTGCCCGTGG	0.607000								Base excision repair (BER), DNA glycosylases	Immune Deficiency with Hyper-IgM				23	90					0	0	1	0	0
TLN2	83660	broad.mit.edu	37	15	63092906	63092906	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr15:63092906G>A	ENST00000561311.1	+	49	6645	c.6415G>A	c.(6415-6417)Gag>Aag	p.E2139K	TLN2_ENST00000306829.6_Missense_Mutation_p.E2139K			Q9Y4G6	TLN2_HUMAN	talin 2	2139					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			NS(3)|breast(6)|central_nervous_system(3)|endometrium(8)|kidney(8)|large_intestine(20)|lung(34)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)	99						AGTGGAGGATGAGGCCACCCG	0.537000													5	14					0	0	1	0	0
ROCK1	6093	broad.mit.edu	37	18	18546939	18546939	+	Silent	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr18:18546939G>A	ENST00000399799.2	-	27	4231	c.3291C>T	c.(3289-3291)ctC>ctT	p.L1097L		NM_005406.2	NP_005397.1	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein kinase 1						actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(4)|central_nervous_system(1)|large_intestine(8)|lung(2)	16	Melanoma(1;0.165)					TAGAATCCGAGAGGTCCAAAA	0.398000													18	45					0	0	1	0	0
USPL1	10208	broad.mit.edu	37	13	31231834	31231834	+	Silent	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr13:31231834C>G	ENST00000255304.4	+	9	1962	c.1620C>G	c.(1618-1620)gcC>gcG	p.A540A		NM_005800.4	NP_005791.3	Q5W0Q7	USPL1_HUMAN	ubiquitin specific peptidase like 1	540					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(15)|pancreas(3)|skin(3)	34		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0306)|Epithelial(112;0.131)|OV - Ovarian serous cystadenocarcinoma(117;0.134)		GTGATGCTGCCTCAGCTGAAA	0.438000													22	66					0	0	1	0	0
KEL	3792	broad.mit.edu	37	7	142640639	142640639	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr7:142640639G>C	ENST00000355265.2	-	15	2111	c.1637C>G	c.(1636-1638)tCt>tGt	p.S546C		NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	546					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					CACATGGTCAGATACCGAATA	0.552000													13	38					0	0	1	0	0
UBE2D3	7323	broad.mit.edu	37	4	103747657	103747657	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr4:103747657C>T	ENST00000453744.2	-	2	522	c.9G>A	c.(7-9)ctG>ctA	p.L3L	UBE2D3_ENST00000357194.6_Intron|UBE2D3_ENST00000513098.1_5'UTR|UBE2D3_ENST00000338145.3_Silent_p.L3L|UBE2D3_ENST00000394804.2_Silent_p.L3L|UBE2D3_ENST00000321805.7_Silent_p.L3L|UBE2D3_ENST00000394803.5_Silent_p.L3L|UBE2D3_ENST00000349311.8_Silent_p.L3L|UBE2D3_ENST00000394801.4_Silent_p.L3L|UBE2D3_ENST00000343106.5_Silent_p.L3L	NM_181891.1	NP_871620.1	P61077	UB2D3_HUMAN	ubiquitin-conjugating enzyme E2D 3	3					apoptosis|BMP signaling pathway|DNA repair|negative regulation of type I interferon production|proteasomal ubiquitin-dependent protein catabolic process|protein K11-linked ubiquitination|protein K48-linked ubiquitination|protein monoubiquitination|transforming growth factor beta receptor signaling pathway	endosome membrane|plasma membrane	ATP binding|protein binding|ubiquitin-protein ligase activity			kidney(1)|lung(3)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.13e-08)		TAATCCGTTTCAGCGCCATAG	0.572000													38	74					0	0	1	0	0
TTC21A	199223	broad.mit.edu	37	3	39175793	39175793	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:39175793G>A	ENST00000301819.6	+	21	3037	c.2860G>A	c.(2860-2862)Gag>Aag	p.E954K	TTC21A_ENST00000440121.1_Missense_Mutation_p.E905K|TTC21A_ENST00000431162.2_Missense_Mutation_p.E953K|TTC21A_ENST00000493856.1_3'UTR	NM_145755.2	NP_665698.2	Q8NDW8	TT21A_HUMAN	tetratricopeptide repeat domain 21A	953							binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(23)|ovary(1)|prostate(1)|skin(3)	50				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		CCTGCAGACTGAGCAGAACCA	0.637000													53	100					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195501046	195501046	+	Silent	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:195501046G>C	ENST00000463781.3	-	4	13533	c.13074C>G	c.(13072-13074)ctC>ctG	p.L4358L	MUC4_ENST00000346145.4_Silent_p.L122L|MUC4_ENST00000475231.1_Silent_p.L4358L|MUC4_ENST00000349607.4_Silent_p.L71L	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	1115					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GACTCACGTAGAGGGAATCAC	0.647000													7	23					0	0	1	0	0
PSPC1	55269	broad.mit.edu	37	13	20356840	20356840	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr13:20356840G>A	ENST00000338910.4	-	1	217	c.58C>T	c.(58-60)Cgc>Tgc	p.R20C		NM_001042414.2	NP_001035879.1	Q8WXF1	PSPC1_HUMAN	paraspeckle component 1	20					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nuclear matrix|nucleolus	nucleotide binding|protein binding|RNA binding			breast(1)|endometrium(1)|large_intestine(4)|lung(10)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23		all_cancers(29;1.25e-22)|all_lung(29;1.97e-20)|all_epithelial(30;2.29e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;4.63e-06)|Epithelial(112;2.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00256)|Lung(94;0.00975)|LUSC - Lung squamous cell carcinoma(192;0.0483)		TCCAGGGCGCGAAGGCGGGCC	0.667000													12	39					0	0	1	0	0
MAP2K3	5606	broad.mit.edu	37	17	21204284	21204284	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr17:21204284C>T	ENST00000342679.4	+	5	627	c.378C>T	c.(376-378)ttC>ttT	p.F126F	MAP2K3_ENST00000361818.5_Silent_p.F97F|MAP2K3_ENST00000316920.6_Silent_p.F97F	NM_145109.2	NP_659731.1	P46734	MP2K3_HUMAN	mitogen-activated protein kinase kinase 3	126	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of transcription, DNA-dependent|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity								COAD - Colon adenocarcinoma(3;0.0131)|Colorectal(15;0.0553)		CTGTCACCTTCTACGGGGCAC	0.587000													22	72					0	0	1	0	0
UNC45B	146862	broad.mit.edu	37	17	33507596	33507596	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr17:33507596G>C	ENST00000268876.5	+	18	2377	c.2280G>C	c.(2278-2280)gaG>gaC	p.E760D	UNC45B_ENST00000394570.2_Missense_Mutation_p.E758D|UNC45B_ENST00000433649.1_Missense_Mutation_p.E758D|UNC45B_ENST00000591048.1_Missense_Mutation_p.E679D|UNC45B_ENST00000378449.1_Missense_Mutation_p.E679D	NM_173167.2	NP_775259.1	Q8IWX7	UN45B_HUMAN	unc-45 homolog B (C. elegans)	760					cell differentiation|muscle organ development	cytosol	binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(10)|lung(24)|ovary(3)|prostate(2)|skin(1)|stomach(1)|urinary_tract(3)	59		Ovarian(249;0.17)				TCTTTAAGGAGAGGGCCTTGC	0.547000													13	28					0	0	1	0	0
MIP	4284	broad.mit.edu	37	12	56847525	56847525	+	Silent	SNP	C	C	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr12:56847525C>A	ENST00000257979.4	-	2	403	c.375G>T	c.(373-375)gtG>gtT	p.V125V	MIP_ENST00000555551.1_5'UTR	NM_012064.3	NP_036196.1	P30301	MIP_HUMAN	major intrinsic protein of lens fiber	125					response to stimulus|visual perception	gap junction|integral to plasma membrane	structural constituent of eye lens			kidney(1)|large_intestine(2)|lung(8)|prostate(1)|skin(3)|urinary_tract(1)	16						GGCCCACGCTCACCGCAGGGT	0.572000													8	12					0.0381472	0.0383852	1	1	0
LIN54	132660	broad.mit.edu	37	4	83905480	83905480	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr4:83905480G>A	ENST00000340417.3	-	2	895	c.518C>T	c.(517-519)tCa>tTa	p.S173L	LIN54_ENST00000446851.2_Intron|LIN54_ENST00000506560.1_Missense_Mutation_p.S173L|LIN54_ENST00000510557.1_Intron|LIN54_ENST00000505397.1_Missense_Mutation_p.S173L|LIN54_ENST00000442461.2_Intron|LIN54_ENST00000395283.2_Missense_Mutation_p.S173L|LIN54_ENST00000395282.2_Missense_Mutation_p.S173L	NM_194282.2	NP_919258.2	Q6MZP7	LIN54_HUMAN	lin-54 homolog (C. elegans)	173					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(2)|lung(5)	14		Hepatocellular(203;0.114)				AGCATCTCCTGACTGGGCCTG	0.468000													10	40					0	0	1	0	0
AC005609.1	0	broad.mit.edu	37	5	140242621	140242621	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr5:140242621C>G	ENST00000502505.1	-	1	603	c.355G>C	c.(355-357)Gat>Cat	p.D119H	PCDHA10_ENST00000506939.2_Intron|PCDHA14_ENST00000562220.1_RNA|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA1_ENST00000394633.3_Intron																							ACAGCTGCATCTGTCAGCTGG	0.637000													9	13					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39854154	39854154	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr1:39854154G>T	ENST00000564288.1	+	58	16417	c.15640G>T	c.(15640-15642)Gag>Tag	p.E5214*	MACF1_ENST00000361689.2_Nonsense_Mutation_p.E3152*|MACF1_ENST00000567887.1_Nonsense_Mutation_p.E5251*|MACF1_ENST00000317713.7_Nonsense_Mutation_p.E3152*|MACF1_ENST00000539005.1_Nonsense_Mutation_p.E3131*|MACF1_ENST00000545844.1_Nonsense_Mutation_p.E3152*|MACF1_ENST00000372915.3_Nonsense_Mutation_p.E5219*|MACF1_ENST00000289893.4_Nonsense_Mutation_p.E3654*			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	5219					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CAAACTGACAGAGAGGGGGAA	0.502000													12	24					4.3838e-07	4.59255e-07	1	1	0
ADCY8	114	broad.mit.edu	37	8	132052131	132052131	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr8:132052131C>T	ENST00000286355.5	-	1	2541	c.449G>A	c.(448-450)cGa>cAa	p.R150Q	ADCY8_ENST00000377928.3_Missense_Mutation_p.R150Q	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	150					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding	p.R150Q(1)		NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			AATGACCCCTCGGTAGCTATA	0.577000										HNSCC(32;0.087)			35	12					0	0	1	0	0
SLC9A1	6548	broad.mit.edu	37	1	27480786	27480786	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr1:27480786G>A	ENST00000263980.3	-	1	615	c.40C>T	c.(40-42)Cgg>Tgg	p.R14W	SLC9A1_ENST00000374086.3_Missense_Mutation_p.R14W|SLC9A1_ENST00000545949.1_5'UTR	NM_003047.4	NP_003038.2	P19634	SL9A1_HUMAN	solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1	14					regulation of pH	integral to membrane	sodium:hydrogen antiporter activity			central_nervous_system(1)|cervix(3)|endometrium(3)|kidney(2)|large_intestine(4)|liver(1)|lung(7)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	27				UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;2.19e-50)|OV - Ovarian serous cystadenocarcinoma(117;1.8e-29)|Colorectal(126;7.61e-09)|COAD - Colon adenocarcinoma(152;9.32e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000521)|KIRC - Kidney renal clear cell carcinoma(1967;0.00079)|STAD - Stomach adenocarcinoma(196;0.00125)|READ - Rectum adenocarcinoma(331;0.046)	Amiloride(DB00594)	GGGAAGATCCGATGTGGAGAG	0.582000													12	49					0	0	1	0	0
HERPUD2	64224	broad.mit.edu	37	7	35675001	35675001	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr7:35675001G>C	ENST00000396081.1	-	6	1489	c.685C>G	c.(685-687)Cta>Gta	p.L229V	HERPUD2_ENST00000426180.1_5'UTR|HERPUD2_ENST00000311350.3_Missense_Mutation_p.L229V	NM_022373.4	NP_071768.3	Q9BSE4	HERP2_HUMAN	HERPUD family member 2	229					response to unfolded protein	integral to membrane				kidney(3)|large_intestine(5)|lung(6)|ovary(3)|prostate(1)	18						GCCAAATTTAGAGGCTGTGAA	0.433000													25	53					0	0	1	0	0
OXCT1	5019	broad.mit.edu	37	5	41870449	41870449	+	Silent	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr5:41870449G>C	ENST00000196371.5	-	1	172	c.12C>G	c.(10-12)ctC>ctG	p.L4L	OXCT1-AS1_ENST00000508458.1_RNA	NM_000436.3	NP_000427.1	P55809	SCOT1_HUMAN	3-oxoacid CoA transferase 1	4					cellular lipid metabolic process|ketone body catabolic process	mitochondrial matrix	3-oxoacid CoA-transferase activity|protein homodimerization activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(1)|skin(2)	28					Succinic acid(DB00139)	AGAGGAGTTTGAGAGCCGCCA	0.677000													5	15					0	0	1	0	0
ACTN2	88	broad.mit.edu	37	1	236918478	236918478	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr1:236918478C>A	ENST00000366578.4	+	17	2300	c.2134C>A	c.(2134-2136)Cac>Aac	p.H712N	ACTN2_ENST00000542672.1_Missense_Mutation_p.H712N|ACTN2_ENST00000546208.1_Missense_Mutation_p.H206N	NM_001103.2|NM_001278343.1	NP_001094.1|NP_001265272.1	P35609	ACTN2_HUMAN	actinin, alpha 2	712					focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			endometrium(4)|kidney(2)|large_intestine(15)|lung(55)|ovary(4)|prostate(3)|skin(3)	86	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			TGACAACAAGCACACGAACTA	0.532000													44	102					1.8453e-21	2.00252e-21	1	1	0
NR2C2	7182	broad.mit.edu	37	3	15073941	15073941	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:15073941C>T	ENST00000425241.1	+	10	1528	c.1166C>T	c.(1165-1167)tCt>tTt	p.S389F	NR2C2_ENST00000406272.2_Missense_Mutation_p.S389F|NR2C2_ENST00000478572.1_3'UTR|NR2C2_ENST00000393102.3_Missense_Mutation_p.S389F|NR2C2_ENST00000323373.6_Missense_Mutation_p.S408F			P49116	NR2C2_HUMAN	nuclear receptor subfamily 2, group C, member 2	389	Ligand-binding (By similarity).				cell differentiation|nervous system development|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|spermatogenesis	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			breast(1)|endometrium(2)|large_intestine(5)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						ATCTGTGAGTCTGCATCCCGT	0.542000													28	83					0	0	1	0	0
DPYSL4	10570	broad.mit.edu	37	10	134013861	134013861	+	Splice_Site	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr10:134013861G>A	ENST00000338492.4	+	9	977	c.813G>A	c.(811-813)ggG>ggA	p.G271G	DPYSL4_ENST00000368627.1_Splice_Site_p.G171G|DPYSL4_ENST00000368629.1_Splice_Site_p.G171G	NM_006426.2	NP_006417.2	O14531	DPYL4_HUMAN	dihydropyrimidinase-like 4	271					axon guidance|pyrimidine base catabolic process	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			NS(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		all_cancers(35;4.33e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;7.21e-05)|Epithelial(32;8.01e-05)|all cancers(32;9.29e-05)|BRCA - Breast invasive adenocarcinoma(275;0.206)		GTGCTGCAGGGGTGGTCGTGT	0.657000													11	36					0	0	1	0	0
KIF20A	10112	broad.mit.edu	37	5	137519714	137519714	+	Silent	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr5:137519714G>A	ENST00000394894.3	+	11	1498	c.1272G>A	c.(1270-1272)ttG>ttA	p.L424L	KIF20A_ENST00000508792.1_Silent_p.L406L	NM_005733.2	NP_005724.1	O95235	KI20A_HUMAN	kinesin family member 20A	424	Kinesin-motor.				cytokinesis|M phase of mitotic cell cycle|microtubule-based movement|protein transport|vesicle-mediated transport	Golgi apparatus|microtubule|nucleoplasm	ATP binding|microtubule motor activity|protein binding|transporter activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|liver(2)|lung(9)|prostate(2)|upper_aerodigestive_tract(1)	27			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			GTGAACGGTTGAAGGAAGCAG	0.502000													18	45					0	0	1	0	0
PIKFYVE	200576	broad.mit.edu	37	2	209200522	209200522	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr2:209200522C>T	ENST00000264380.4	+	26	4420	c.4262C>T	c.(4261-4263)tCa>tTa	p.S1421L	PIKFYVE_ENST00000474721.1_3'UTR	NM_015040.3	NP_055855.2	Q9Y2I7	FYV1_HUMAN	phosphoinositide kinase, FYVE finger containing	1421					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(14)|kidney(6)|large_intestine(25)|lung(40)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	107						GTTAGAGTTTCACAGGTATAT	0.299000													10	25					0	0	1	0	0
ZC3HC1	51530	broad.mit.edu	37	7	129691095	129691095	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr7:129691095C>T	ENST00000358303.4	-	1	196	c.112G>A	c.(112-114)Gag>Aag	p.E38K	ZC3HC1_ENST00000311873.5_Start_Codon_SNP_p.M1I|ZC3HC1_ENST00000360708.5_Missense_Mutation_p.E38K|ZC3HC1_ENST00000481503.1_Missense_Mutation_p.E38K	NM_016478.3	NP_057562.3	Q86WB0	NIPA_HUMAN	zinc finger, C3HC-type containing 1	38					cell division|mitosis	nucleus	protein kinase binding|zinc ion binding			endometrium(2)|kidney(6)|large_intestine(10)|lung(2)|prostate(1)|urinary_tract(1)	22	Melanoma(18;0.0435)					GCAATCCCCTCATCTATCAGC	0.587000													17	44					0	0	1	0	0
KCTD13	253980	broad.mit.edu	37	16	29918373	29918373	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr16:29918373C>T	ENST00000568000.1	-	6	1811	c.810G>A	c.(808-810)gaG>gaA	p.E270E		NM_178863.3	NP_849194.1	Q8WZ19	BACD1_HUMAN	potassium channel tetramerization domain containing 13	270					cell migration|DNA replication|negative regulation of Rho protein signal transduction|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|nucleus|voltage-gated potassium channel complex	GTP-Rho binding|voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(2)	7						CCCGGGGAGTCTCGTAGATGA	0.652000													7	36					0	0	1	0	0
TSPEAR	54084	broad.mit.edu	37	21	45949708	45949708	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr21:45949708C>T	ENST00000323084.4	-	5	828	c.763G>A	c.(763-765)Gat>Aat	p.D255N	TSPEAR_ENST00000397916.1_Missense_Mutation_p.D187N	NM_001272037.1|NM_144991.2	NP_001258966.1|NP_659428.2	Q8WU66	TSEAR_HUMAN	thrombospondin-type laminin G domain and EAR repeats	255					cell adhesion	extracellular region	structural molecule activity			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	37						ACCTCGTTATCTTCTGGCTTC	0.642000													10	42					0	0	1	0	0
ABCG4	64137	broad.mit.edu	37	11	119031756	119031756	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr11:119031756C>T	ENST00000307417.3	+	15	2245	c.1881C>T	c.(1879-1881)ttC>ttT	p.F627F	ABCG4_ENST00000449422.2_Silent_p.F627F|ABCG4_ENST00000531739.1_Silent_p.F627F	NM_022169.4	NP_071452.2	Q9H172	ABCG4_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 4	627	ABC transmembrane type-2.				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(28)|ovary(2)|prostate(1)|skin(1)	44	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		GCATCTTCTTCCTAGCCCTGC	0.612000													18	33					0	0	1	0	0
TRIM25	7706	broad.mit.edu	37	17	54969498	54969498	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr17:54969498G>C	ENST00000316881.4	-	9	1505	c.1456C>G	c.(1456-1458)Cag>Gag	p.Q486E	TRIM25_ENST00000537230.1_Missense_Mutation_p.Q486E	NM_005082.4	NP_005073.2	Q14258	TRI25_HUMAN	tripartite motif containing 25	486	B30.2/SPRY.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|response to virus	cell junction|cytosol|nucleus	sequence-specific DNA binding transcription factor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(2)|kidney(4)|large_intestine(3)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Breast(9;6.15e-08)					CGGTAGTTCTGAGGCATCTCA	0.527000													29	48					0	0	1	0	0
USP32	84669	broad.mit.edu	37	17	58270257	58270257	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr17:58270257G>C	ENST00000300896.4	-	28	3663	c.3469C>G	c.(3469-3471)Cta>Gta	p.L1157V	USP32_ENST00000592339.1_Missense_Mutation_p.L827V	NM_032582.3	NP_115971.2	Q8NFA0	UBP32_HUMAN	ubiquitin specific peptidase 32	1157					protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(5)|endometrium(5)|kidney(4)|large_intestine(12)|liver(1)|lung(24)|pancreas(1)|prostate(3)|skin(3)|urinary_tract(1)	62	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			ACAACTCGTAGAGTGAATGGA	0.413000													8	26					0	0	1	0	0
HPGDS	27306	broad.mit.edu	37	4	95229825	95229825	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr4:95229825A>T	ENST00000295256.5	-	4	386	c.296T>A	c.(295-297)aTg>aAg	p.M99K	HPGDS_ENST00000514774.1_5'UTR	NM_014485.2	NP_055300.1	O60760	HPGDS_HUMAN	hematopoietic prostaglandin D synthase	99	GST C-terminal.				locomotory behavior|prostaglandin biosynthetic process|signal transduction	cytoplasm|nucleus	calcium ion binding|glutathione transferase activity|magnesium ion binding|prostaglandin-D synthase activity|protein homodimerization activity			breast(1)|cervix(1)|lung(3)|ovary(1)|urinary_tract(1)	7					Glutathione(DB00143)	AAAACATGACATGAAATCATC	0.388000													14	53					0	0	1	0	0
MYH10	4628	broad.mit.edu	37	17	8415901	8415901	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr17:8415901C>A	ENST00000360416.3	-	24	2958	c.2820G>T	c.(2818-2820)atG>atT	p.M940I	MYH10_ENST00000379980.4_Missense_Mutation_p.M925I|MYH10_ENST00000396239.1_Missense_Mutation_p.M930I|MYH10_ENST00000269243.4_Missense_Mutation_p.M909I	NM_001256012.1	NP_001242941.1	P35580	MYH10_HUMAN	myosin, heavy chain 10, non-muscle	909					actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			breast(5)|endometrium(9)|kidney(2)|large_intestine(16)|lung(9)|ovary(3)|prostate(3)|skin(4)|stomach(1)	52						GTCTTGCCCTCATCTCTTCTG	0.403000													7	15					5.18039e-06	5.40368e-06	1	1	0
SLIT2	9353	broad.mit.edu	37	4	20552484	20552484	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr4:20552484G>A	ENST00000504154.1	+	25	2776	c.2524G>A	c.(2524-2526)Gaa>Aaa	p.E842K	SLIT2_ENST00000273739.5_Missense_Mutation_p.E846K|SLIT2_ENST00000503837.1_Missense_Mutation_p.E838K|SLIT2_ENST00000503823.1_Missense_Mutation_p.E834K|SLIT2_ENST00000509394.2_3'UTR	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	842					apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						TGTTGTGCCTGAAGGTGCTTT	0.343000													5	22					0	0	1	0	0
ARL2-SNX15	100528018	broad.mit.edu	37	11	64781688	64781688	+	Silent	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr11:64781688C>G	ENST00000301886.3	+	1	35	c.9C>G	c.(7-9)ctC>ctG	p.L3L	ARL2_ENST00000533729.1_Silent_p.L3L|ARL2_ENST00000246747.4_Silent_p.L3L|ARL2_ENST00000529384.1_Silent_p.L3L																							CCATGGGGCTCCTGACCATTC	0.662000													6	14					0	0	1	0	0
NBEA	26960	broad.mit.edu	37	13	35733432	35733432	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr13:35733432G>C	ENST00000540320.1	+	22	3658	c.3124G>C	c.(3124-3126)Gat>Cat	p.D1042H	NBEA_ENST00000400445.3_Missense_Mutation_p.D1042H|NBEA_ENST00000379939.2_Missense_Mutation_p.D1042H|NBEA_ENST00000310336.4_Missense_Mutation_p.D1042H			Q8NFP9	NBEA_HUMAN	neurobeachin	1042						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		TGGAAATTCAGATAGACCAGG	0.408000													11	27					0	0	1	0	0
KDM4A	9682	broad.mit.edu	37	1	44128717	44128717	+	Silent	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr1:44128717C>G	ENST00000372396.3	+	5	716	c.582C>G	c.(580-582)ctC>ctG	p.L194L	KDM4A_ENST00000463151.1_3'UTR	NM_014663.2	NP_055478.2	O75164	KDM4A_HUMAN	lysine (K)-specific demethylase 4A	194	JmjC.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleolus	histone demethylase activity (H3-K36 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(13)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	37						ACATGGACCTCTACAGCATCA	0.512000													24	62					0	0	1	0	0
PTPRO	5800	broad.mit.edu	37	12	15637019	15637019	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr12:15637019G>A	ENST00000281171.4	+	2	517	c.187G>A	c.(187-189)Gaa>Aaa	p.E63K	PTPRO_ENST00000348962.2_Missense_Mutation_p.E63K|PTPRO_ENST00000543886.1_Missense_Mutation_p.E63K	NM_030667.2	NP_109592.1	Q16827	PTPRO_HUMAN	protein tyrosine phosphatase, receptor type, O	63	Fibronectin type-III 1.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(2)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(11)|lung(30)|ovary(2)|prostate(1)|skin(17)|upper_aerodigestive_tract(1)	74		Hepatocellular(102;0.244)				GATAACTGGTGAATCCAAAAA	0.368000													7	12					0	0	1	0	0
PALB2	79728	broad.mit.edu	37	16	23641139	23641139	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr16:23641139G>A	ENST00000261584.4	-	5	2488	c.2336C>T	c.(2335-2337)tCa>tTa	p.S779L		NM_024675.3	NP_078951.2	Q86YC2	PALB2_HUMAN	partner and localizer of BRCA2	779					double-strand break repair via homologous recombination	nucleoplasm	DNA binding|protein binding			breast(5)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(21)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(3)	55				GBM - Glioblastoma multiforme(48;0.0167)		TGGGCTGCCTGAACTGTCGAA	0.522000			"""F, N, Mis"""			"""Wilms tumor, medulloblastoma, AML ,breast"""		Involved in tolerance or repair of DNA crosslinks					4	19					0	0	1	0	0
SLC6A17	388662	broad.mit.edu	37	1	110709770	110709770	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr1:110709770G>T	ENST00000331565.4	+	2	704	c.219G>T	c.(217-219)caG>caT	p.Q73H	RP5-1028L10.1_ENST00000430098.1_RNA|RP5-1028L10.1_ENST00000418579.1_RNA|RP5-1028L10.1_ENST00000443008.1_RNA	NM_001010898.2	NP_001010898.1	Q9H1V8	S6A17_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 17	73					alanine transport|glycine transport|leucine transport|proline transport	cell junction|integral to plasma membrane|synaptic vesicle membrane	neurotransmitter:sodium symporter activity			breast(1)|endometrium(4)|kidney(4)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	37		all_cancers(81;9.9e-06)|all_epithelial(167;3.24e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0282)|Epithelial(280;0.0372)|all cancers(265;0.0378)|Colorectal(144;0.0438)|LUSC - Lung squamous cell carcinoma(189;0.151)|COAD - Colon adenocarcinoma(174;0.151)		TCCTGGCCCAGATTGGCTTCT	0.612000													9	18					4.68919e-08	4.94459e-08	1	1	0
CLTC	1213	broad.mit.edu	37	17	57762430	57762430	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr17:57762430C>T	ENST00000269122.3	+	29	4722	c.4448C>T	c.(4447-4449)tCa>tTa	p.S1483L	CLTC_ENST00000579456.1_Missense_Mutation_p.S420L|CLTC_ENST00000393043.1_Missense_Mutation_p.S1483L	NM_004859.3	NP_004850.1	Q00610	CLH1_HUMAN	clathrin, heavy chain (Hc)	1483	Heavy chain arm.|Involved in binding clathrin light chain (By similarity).|Proximal segment.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	breast(2)|large_intestine(6)|ovary(1)	9	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					CTGCGAACATCAATAGATGCT	0.368000			T	"""ALK, TFE3"""	"""ALCL, renal """								13	38					0	0	1	0	0
TRIM23	373	broad.mit.edu	37	5	64900773	64900773	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr5:64900773G>T	ENST00000231524.9	-	7	1515	c.1144C>A	c.(1144-1146)Cag>Aag	p.Q382K	TRIM23_ENST00000381018.3_Missense_Mutation_p.Q382K|TRIM23_ENST00000274327.7_Missense_Mutation_p.Q382K	NM_001656.3	NP_001647.1	P36406	TRI23_HUMAN	tripartite motif containing 23	382					interspecies interaction between organisms|small GTPase mediated signal transduction	Golgi membrane|lysosomal membrane	enzyme activator activity|GDP binding|GTP binding|GTPase activity|protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(5)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	28		Lung NSC(167;3.24e-06)|Prostate(74;0.0138)|Breast(144;0.0433)|Ovarian(174;0.0545)|Colorectal(97;0.234)		Lung(70;0.00473)		GCATCCAACTGAATGTGATCT	0.363000													14	41					1.05317e-09	1.12276e-09	1	1	0
EML1	2009	broad.mit.edu	37	14	100405642	100405642	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr14:100405642C>T	ENST00000262233.6	+	21	2439	c.2300C>T	c.(2299-2301)tCa>tTa	p.S767L	EML1_ENST00000334192.4_Missense_Mutation_p.S786L|EML1_ENST00000327921.9_Missense_Mutation_p.S755L	NM_004434.2	NP_004425.2	O00423	EMAL1_HUMAN	echinoderm microtubule associated protein like 1	767						cytoplasm|microtubule|microtubule associated complex	calcium ion binding|protein binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Melanoma(154;0.0879)|all_epithelial(191;0.216)				CACCTCTTCTCATACCCCTGC	0.537000													18	29					0	0	1	0	0
TRIP13	9319	broad.mit.edu	37	5	893162	893162	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr5:893162G>A	ENST00000166345.3	+	1	405	c.49G>A	c.(49-51)Gag>Aag	p.E17K		NM_004237.3	NP_004228.1	Q15645	PCH2_HUMAN	thyroid hormone receptor interactor 13	17					double-strand break repair|reciprocal meiotic recombination|synaptonemal complex assembly|transcription from RNA polymerase II promoter		ATP binding|identical protein binding|nucleoside-triphosphatase activity|transcription cofactor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	18			Epithelial(17;0.00147)|OV - Ovarian serous cystadenocarcinoma(19;0.00271)|all cancers(22;0.00622)|Lung(60;0.165)			CTGTGTGGCCGAGTCGCCAAC	0.731000													3	8					0	0	1	0	0
PTGIS	5740	broad.mit.edu	37	20	48129668	48129668	+	Silent	SNP	G	G	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr20:48129668G>T	ENST00000244043.4	-	8	1184	c.1155C>A	c.(1153-1155)ctC>ctA	p.L385L	PTGIS_ENST00000478971.1_5'UTR	NM_000961.3	NP_000952.1	Q16647	PTGIS_HUMAN	prostaglandin I2 (prostacyclin) synthase	385					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|prostaglandin-I synthase activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(6)|ovary(3)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	27			BRCA - Breast invasive adenocarcinoma(12;2.37e-05)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)		Phenylbutazone(DB00812)	GGAAGGGGAAGAGGAGGAGGC	0.607000													19	67					1.96292e-10	2.10189e-10	1	1	0
PHLPP1	23239	broad.mit.edu	37	18	60646311	60646311	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr18:60646311G>T	ENST00000400316.4	+	17	5046	c.3265G>T	c.(3265-3267)Gag>Tag	p.E1089*	PHLPP1_ENST00000262719.5_Nonsense_Mutation_p.E1601*	NM_194449.3	NP_919431.2	O60346	PHLP1_HUMAN	PH domain and leucine rich repeat protein phosphatase 1	1601					apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|membrane|nucleus	metal ion binding|protein serine/threonine phosphatase activity			endometrium(2)|kidney(2)|lung(13)	17						CAGCGCCAACGAGGATGAGCC	0.622000													9	22					2.17888e-05	2.26304e-05	1	1	0
KIF26A	26153	broad.mit.edu	37	14	104641567	104641567	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr14:104641567C>T	ENST00000315264.7	+	11	2403	c.2025C>T	c.(2023-2025)ttC>ttT	p.F675F	KIF26A_ENST00000423312.2_Silent_p.F814F			Q9ULI4	KI26A_HUMAN	kinesin family member 26A	814					blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	21		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		CGCCTGACTTCGTGCCCATCA	0.692000													11	11					0	0	1	0	0
CDH12	1010	broad.mit.edu	37	5	21817178	21817178	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr5:21817178G>A	ENST00000382254.1	-	9	1964	c.878C>T	c.(877-879)gCt>gTt	p.A293V	CDH12_ENST00000522262.1_Missense_Mutation_p.A253V|CDH12_ENST00000521384.1_5'UTR|CDH12_ENST00000504376.2_Missense_Mutation_p.A293V	NM_004061.3	NP_004052.2	P55289	CAD12_HUMAN	cadherin 12, type 2 (N-cadherin 2)	293	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(19)|lung(75)|ovary(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	120						AGGATCCACAGCTCTTATTCT	0.388000										HNSCC(59;0.17)			12	33					0	0	1	0	0
GTF2F1	2962	broad.mit.edu	37	19	6387440	6387440	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr19:6387440G>A	ENST00000394456.5	-	5	921	c.457C>T	c.(457-459)Cgc>Tgc	p.R153C	GTF2F1_ENST00000429701.2_Intron|CTB-180A7.6_ENST00000599584.1_RNA	NM_002096.2	NP_002087.2	P35269	T2FA_HUMAN	general transcription factor IIF, polypeptide 1, 74kDa	153					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|response to virus|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cell junction|transcription factor TFIIF complex	catalytic activity|DNA binding|phosphatase activator activity|transcription coactivator activity|transcription factor binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(4)	16						GTGAGCGTGCGATGCCGGGCC	0.632000													18	60					0	0	1	0	0
ZIM3	114026	broad.mit.edu	37	19	57647074	57647074	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr19:57647074C>G	ENST00000269834.1	-	5	1016	c.631G>C	c.(631-633)Gat>Cat	p.D211H		NM_052882.1	NP_443114.1	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	211					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(27)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	52		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TGATGTTTATCAAGCTTCCAC	0.433000													30	72					0	0	1	0	0
NKAP	79576	broad.mit.edu	37	X	119063990	119063990	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chrX:119063990C>T	ENST00000371410.3	-	8	1228	c.1062G>A	c.(1060-1062)atG>atA	p.M354I	NKAP_ENST00000477789.1_5'UTR	NM_024528.3	NP_078804.2	Q8N5F7	NKAP_HUMAN	NFKB activating protein	354	Necessary for interaction with HDAC3 and transcriptional repression.				negative regulation of transcription, DNA-dependent|Notch signaling pathway|positive regulation of alpha-beta T cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|protein binding			breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|prostate(1)	20						TGCTACCACTCATTACATAAC	0.348000													25	19					0	0	1	0	0
PEX12	5193	broad.mit.edu	37	17	33904291	33904291	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr17:33904291G>C	ENST00000225873.4	-	2	1053	c.446C>G	c.(445-447)tCt>tGt	p.S149C		NM_000286.2	NP_000277.1	O00623	PEX12_HUMAN	peroxisomal biogenesis factor 12	149					protein import into peroxisome matrix	integral to peroxisomal membrane	protein C-terminus binding|zinc ion binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|liver(1)|lung(8)	18				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CCAGCGGGAAGAAGGGGGATG	0.448000													18	29					0	0	1	0	0
RAI14	26064	broad.mit.edu	37	5	34812041	34812041	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr5:34812041C>G	ENST00000265109.3	+	9	1014	c.727C>G	c.(727-729)Cag>Gag	p.Q243E	RAI14_ENST00000397449.1_Missense_Mutation_p.Q236E|RAI14_ENST00000503673.1_Missense_Mutation_p.Q243E|RAI14_ENST00000515799.1_Missense_Mutation_p.Q246E|RAI14_ENST00000428746.2_Missense_Mutation_p.Q243E|RAI14_ENST00000512629.1_Missense_Mutation_p.Q243E|RAI14_ENST00000506376.1_Missense_Mutation_p.Q235E	NM_001145522.1|NM_015577.2	NP_001138994.1|NP_056392.2	Q9P0K7	RAI14_HUMAN	retinoic acid induced 14	243						cell cortex|cytoskeleton	protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(19)|lung(22)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	56	all_lung(31;0.000191)					AAAAATCTCTCAGGATGCTGG	0.333000													6	19					0	0	1	0	0
MCC	4163	broad.mit.edu	37	5	112479015	112479015	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr5:112479015C>G	ENST00000302475.4	-	3	777	c.214G>C	c.(214-216)Gag>Cag	p.E72Q	MCC_ENST00000408903.3_Missense_Mutation_p.E262Q|MCC_ENST00000514701.3_5'UTR|MCC_ENST00000515367.2_Missense_Mutation_p.E9Q	NM_002387.2	NP_002378	P23508	CRCM_HUMAN	mutated in colorectal cancers	72					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			endometrium(4)|kidney(3)|large_intestine(15)|liver(2)|lung(8)|ovary(2)|pancreas(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		GTCGTTCGCTCCTGGACATCC	0.527000													5	28					0	0	1	0	0
DGKA	1606	broad.mit.edu	37	12	56334743	56334743	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr12:56334743G>C	ENST00000331886.5	+	13	1534	c.1080G>C	c.(1078-1080)ttG>ttC	p.L360F	DGKA_ENST00000394147.1_Missense_Mutation_p.L360F|DGKA_ENST00000549079.2_3'UTR|DGKA_ENST00000551156.1_Missense_Mutation_p.L360F	NM_001345.4	NP_001336.2	P23743	DGKA_HUMAN	diacylglycerol kinase, alpha 80kDa	360					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(1)|endometrium(3)|large_intestine(1)|lung(11)|ovary(4)|pancreas(1)|skin(3)|urinary_tract(1)	25					Vitamin E(DB00163)	ATTTAAATTTGAGCACCTCTG	0.507000													4	13					0	0	1	0	0
UHRF1BP1	54887	broad.mit.edu	37	6	34826003	34826003	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr6:34826003C>T	ENST00000192788.5	+	14	2041	c.1870C>T	c.(1870-1872)Cca>Tca	p.P624S	UHRF1BP1_ENST00000452449.2_Missense_Mutation_p.P624S	NM_017754.3	NP_060224.3	Q6BDS2	URFB1_HUMAN	UHRF1 binding protein 1	624										breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(24)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	54						ACGTCATGCTCCACATTGTAG	0.507000													10	45					0	0	1	0	0
ABR	29	broad.mit.edu	37	17	959301	959301	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr17:959301G>C	ENST00000544583.2	-	14	1996	c.1397C>G	c.(1396-1398)tCt>tGt	p.S466C	ABR_ENST00000536794.2_Missense_Mutation_p.S294C|ABR_ENST00000291107.2_Missense_Mutation_p.S475C|ABR_ENST00000574437.1_Missense_Mutation_p.S466C|ABR_ENST00000302538.5_Missense_Mutation_p.S512C|ABR_ENST00000573895.1_5'UTR	NM_001159746.2	NP_001153218.1	Q12979	ABR_HUMAN	active BCR-related	512	C2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39				UCEC - Uterine corpus endometrioid carcinoma (25;0.0228)		TCCCTTGGCAGAGTGGACGAT	0.582000											OREG0024067	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	32					0	0	1	0	0
FRMD5	84978	broad.mit.edu	37	15	44180390	44180390	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr15:44180390C>T	ENST00000417257.1	-	10	1043	c.867G>A	c.(865-867)gaG>gaA	p.E289E	FRMD5_ENST00000402883.1_Silent_p.E289E|FRMD5_ENST00000484674.1_Silent_p.E195E	NM_032892.3	NP_116281.2	Q7Z6J6	FRMD5_HUMAN	FERM domain containing 5	289	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			breast(2)|cervix(1)|endometrium(2)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	14		all_cancers(109;2.29e-15)|all_epithelial(112;9.98e-13)|Lung NSC(122;4.89e-08)|all_lung(180;5.08e-07)|Melanoma(134;0.0275)		all cancers(107;8.63e-20)|GBM - Glioblastoma multiforme(94;3.63e-06)		AGGCTTGGTTCTCGATTCCAC	0.448000													11	25					0	0	1	0	0
PPL	5493	broad.mit.edu	37	16	4934788	4934788	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr16:4934788C>G	ENST00000345988.2	-	22	3957	c.3868G>C	c.(3868-3870)Gag>Cag	p.E1290Q	PPL_ENST00000590782.2_Missense_Mutation_p.E1288Q	NM_002705.4	NP_002696	O60437	PEPL_HUMAN	periplakin	1290					keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			breast(6)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(12)|lung(12)|ovary(4)|prostate(5)|skin(3)|stomach(1)|urinary_tract(2)	62						TGGACCACCTCTTTGGTCTGG	0.507000													27	90					0	0	1	0	0
PTH1R	5745	broad.mit.edu	37	3	46943273	46943273	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:46943273C>T	ENST00000313049.5	+	11	1337	c.1134C>T	c.(1132-1134)ttC>ttT	p.F378F	PTH1R_ENST00000449590.1_Silent_p.F378F|PTH1R_ENST00000418619.1_Silent_p.F378F|PTH1R_ENST00000430002.2_Silent_p.F378F			Q03431	PTH1R_HUMAN	parathyroid hormone 1 receptor	378						cytoplasm|integral to plasma membrane|nucleus	parathyroid hormone receptor activity|peptide hormone binding|protein self-association			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(5)|skin(2)|stomach(1)|urinary_tract(2)	19						TCATCCTCTTCATCAATATCG	0.657000													17	35					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108216934	108216934	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:108216934T>C	ENST00000273353.3	-	7	699	c.643A>G	c.(643-645)Acc>Gcc	p.T215A		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	215	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						GCTGCTATGGTGGCAAAATAC	0.408000													4	75					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179421681	179421681	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr2:179421681C>G	ENST00000589042.1	-	330	88424	c.88200G>C	c.(88198-88200)ttG>ttC	p.L29400F	TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.L20527F|TTN-AS1_ENST00000592600.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.L20460F|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.L20335F|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.L27759F|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.L26832F	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	27759	Fibronectin type-III 114.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AATTCTGAGTCAAGCCAGAGA	0.453000													14	20					0	0	1	0	0
CDK17	5128	broad.mit.edu	37	12	96704910	96704910	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr12:96704910C>T	ENST00000261211.3	-	5	1066	c.463G>A	c.(463-465)Gat>Aat	p.D155N	CDK17_ENST00000542666.1_Missense_Mutation_p.D102N|CDK17_ENST00000543119.2_Missense_Mutation_p.D155N	NM_001170464.2|NM_002595.4	NP_001163935.1|NP_002586.2	Q00537	CDK17_HUMAN	cyclin-dependent kinase 17	155							ATP binding|cyclin-dependent protein kinase activity			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(6)|lung(11)|ovary(4)|prostate(2)|skin(1)	37						AGATATCCATCAGGTATTCTG	0.373000													9	40					0	0	1	0	0
ZNF425	155054	broad.mit.edu	37	7	148801215	148801215	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr7:148801215G>A	ENST00000378061.2	-	4	1880	c.1748C>T	c.(1747-1749)gCg>gTg	p.A583V		NM_001001661.2	NP_001001661.1	Q6IV72	ZN425_HUMAN	zinc finger protein 425	583					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(6)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	50	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			CTCACCGCACGCGAAGGGCTT	0.602000													11	41					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178916810	178916810	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:178916810C>G	ENST00000263967.3	+	2	354	c.197C>G	c.(196-198)tCt>tGt	p.S66C		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	66	PI3K-ABD.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			CAAGATGAATCTTCTTACATT	0.358000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			15	41					0	0	1	0	0
RAPGEF2	9693	broad.mit.edu	37	4	160262807	160262807	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr4:160262807C>G	ENST00000264431.4	+	14	2562	c.2143C>G	c.(2143-2145)Cag>Gag	p.Q715E		NM_014247.2	NP_055062.1	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor (GEF) 2	715					cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	70	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		TTCCCTCCTTCAGCTCAGCAC	0.363000													6	18					0	0	1	0	0
CHD9	80205	broad.mit.edu	37	16	53326744	53326744	+	Splice_Site	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr16:53326744G>C	ENST00000566029.1	+	29	5499		c.e29-1		CHD9_ENST00000447540.1_Splice_Site|CHD9_ENST00000398510.3_Splice_Site|CHD9_ENST00000564845.1_Splice_Site			Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9						cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(32)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	78		all_cancers(37;0.0212)				TTTAACTATAGATGGTCAACT	0.333000													10	27					0	0	1	0	0
NBAS	51594	broad.mit.edu	37	2	15693566	15693566	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr2:15693566G>T	ENST00000281513.5	-	5	344	c.319C>A	c.(319-321)Cag>Aag	p.Q107K	NBAS_ENST00000441750.1_Missense_Mutation_p.Q107K	NM_015909.3	NP_056993.2	A2RRP1	NBAS_HUMAN	neuroblastoma amplified sequence	107										NS(4)|breast(4)|central_nervous_system(3)|endometrium(6)|kidney(5)|large_intestine(12)|liver(1)|lung(54)|ovary(2)|pancreas(3)|prostate(9)|skin(6)|stomach(3)	112						TCCACACACTGATCTTGAACA	0.318000													3	10					0.014758	0.0149432	1	1	0
SGOL1	151648	broad.mit.edu	37	3	20215771	20215771	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:20215771C>G	ENST00000412997.1	-	6	1603	c.1252G>C	c.(1252-1254)Gag>Cag	p.E418Q	SGOL1_ENST00000421451.1_Missense_Mutation_p.E418Q|SGOL1_ENST00000437051.1_Intron|SGOL1-AS1_ENST00000448208.1_RNA|SGOL1_ENST00000412868.1_Missense_Mutation_p.E418Q|SGOL1_ENST00000419233.2_Intron|SGOL1_ENST00000425061.1_Intron|SGOL1_ENST00000452020.1_Intron|SGOL1_ENST00000383774.1_Intron|SGOL1_ENST00000306698.2_Intron|SGOL1_ENST00000429446.3_Intron|SGOL1_ENST00000417364.1_Intron|SGOL1_ENST00000442720.1_Intron|SGOL1_ENST00000263753.4_Missense_Mutation_p.E418Q|SGOL1_ENST00000443724.1_Intron	NM_001199251.1	NP_001186180.1	Q5FBB7	SGOL1_HUMAN	shugoshin-like 1 (S. pombe)	418					attachment of spindle microtubules to kinetochore|cell division|centriole-centriole cohesion|meiotic chromosome segregation|mitotic prometaphase	centrosome|condensed chromosome kinetochore|cytosol|mitotic cohesin complex|spindle pole	protein binding			kidney(1)|large_intestine(4)|lung(6)|skin(1)|urinary_tract(2)	14						TTAGAACCCTCCGTCTCTTTT	0.398000													6	31					0	0	1	0	0
SFXN2	118980	broad.mit.edu	37	10	104486809	104486809	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr10:104486809C>G	ENST00000369893.5	+	3	394	c.227C>G	c.(226-228)tCg>tGg	p.S76W	SFXN2_ENST00000602785.1_3'UTR	NM_178858.4	NP_849189.1	Q96NB2	SFXN2_HUMAN	sideroflexin 2						iron ion homeostasis	integral to membrane	cation transmembrane transporter activity	p.S76L(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(3)|prostate(1)	13		Colorectal(252;0.207)		Epithelial(162;4.53e-09)|all cancers(201;1.2e-07)|BRCA - Breast invasive adenocarcinoma(275;0.218)		CTGTATGACTCGGCCTTCCAC	0.592000													14	32					0	0	1	0	0
PCDHB4	56131	broad.mit.edu	37	5	140503379	140503379	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr5:140503379G>A	ENST00000194152.1	+	1	1799	c.1799G>A	c.(1798-1800)tGg>tAg	p.W600*		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		600	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAGAACGCCTGGCTGTCGTAC	0.731000													27	87					0	0	1	0	0
ABHD16A	7920	broad.mit.edu	37	6	31656058	31656058	+	Silent	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr6:31656058G>A	ENST00000375842.4	-	15	1604	c.618C>T	c.(616-618)atC>atT	p.I206I	ABHD16A_ENST00000395952.3_Silent_p.I425I|XXbac-BPG32J3.20_ENST00000461287.1_3'UTR|ABHD16A_ENST00000440843.2_Silent_p.I392I|ABHD16A_ENST00000471644.1_5'UTR			O95870	ABHGA_HUMAN	abhydrolase domain containing 16A	425						integral to membrane	hydrolase activity|protein binding			endometrium(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)	10						TGGTTCTCCGGATCAGCAGTA	0.577000													22	55					0	0	1	0	0
ZKSCAN5	23660	broad.mit.edu	37	7	99103922	99103922	+	Silent	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr7:99103922G>A	ENST00000394170.2	+	2	506	c.255G>A	c.(253-255)acG>acA	p.T85T	ZKSCAN5_ENST00000451158.1_Silent_p.T85T|ZKSCAN5_ENST00000326775.5_Silent_p.T85T	NM_014569.3	NP_055384.1	Q9Y2L8	ZKSC5_HUMAN	zinc finger with KRAB and SCAN domains 5	85	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	21	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					AGCTGCACACGAAGGAGCAGA	0.612000													20	65					0	0	1	0	0
ANAPC5	51433	broad.mit.edu	37	12	121779868	121779868	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr12:121779868C>A	ENST00000261819.3	-	5	716	c.595G>T	c.(595-597)Gag>Tag	p.E199*	ANAPC5_ENST00000541887.1_Nonsense_Mutation_p.E199*|ANAPC5_ENST00000536366.1_Nonsense_Mutation_p.E78*|ANAPC5_ENST00000344395.4_Nonsense_Mutation_p.E100*|ANAPC5_ENST00000441917.2_Nonsense_Mutation_p.E100*	NM_016237.4	NP_057321.2	Q9UJX4	APC5_HUMAN	anaphase promoting complex subunit 5	199					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G2/M transition of mitotic cell cycle|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding|ubiquitin-protein ligase activity			breast(6)|endometrium(3)|kidney(3)|large_intestine(5)|lung(10)|prostate(1)|skin(3)	31	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					GATACCTCCTCTTCTCTGGAA	0.303000													9	23					2.74318e-10	2.9309e-10	1	1	0
C1orf141	400757	broad.mit.edu	37	1	67592905	67592905	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr1:67592905C>G	ENST00000371007.2	-	3	128	c.19G>C	c.(19-21)Gag>Cag	p.E7Q	C1orf141_ENST00000371006.1_Missense_Mutation_p.E7Q|C1orf141_ENST00000544837.1_Missense_Mutation_p.E7Q	NM_001276351.1	NP_001263280.1	Q5JVX7	CA141_HUMAN	chromosome 1 open reading frame 141	7										NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(8)|ovary(1)|skin(1)	18						TCCAACTTCTCTAGGATTTTT	0.323000													12	39					0	0	1	0	0
IRAK3	11213	broad.mit.edu	37	12	66641487	66641487	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr12:66641487C>G	ENST00000261233.4	+	12	1748	c.1327C>G	c.(1327-1329)Ctt>Gtt	p.L443V	IRAK3_ENST00000457197.2_Missense_Mutation_p.L382V	NM_007199.2	NP_009130.2	Q9Y616	IRAK3_HUMAN	interleukin-1 receptor-associated kinase 3	443	Protein kinase.				interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|negative regulation of innate immune response|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of macrophage cytokine production|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein catabolic process|negative regulation of protein complex disassembly|negative regulation of toll-like receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of macrophage tolerance induction|positive regulation of NF-kappaB transcription factor activity|response to exogenous dsRNA|response to lipopolysaccharide|response to peptidoglycan	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein heterodimerization activity|protein homodimerization activity|protein serine/threonine kinase activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(28;0.0203)		TTTAAATACTCTTGAAAGTAC	0.343000													6	12					0	0	1	0	0
AMIGO3	386724	broad.mit.edu	37	3	49755899	49755899	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:49755899C>T	ENST00000535833.1	-	10	4450	c.1000G>A	c.(1000-1002)Gac>Aac	p.D334N	AMIGO3_ENST00000320431.7_Missense_Mutation_p.D334N|RNF123_ENST00000497099.1_3'UTR|GMPPB_ENST00000480687.1_3'UTR|RNF123_ENST00000327697.6_Intron|RNF123_ENST00000433785.1_Intron			Q86WK7	AMGO3_HUMAN	adhesion molecule with Ig-like domain 3	334	Ig-like C2-type.				heterophilic cell-cell adhesion	integral to membrane				endometrium(1)|pancreas(1)|prostate(2)|urinary_tract(1)	5				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		AAGCTGCCGTCGGCCAGCACC	0.667000													15	35					0	0	1	0	0
IRX5	10265	broad.mit.edu	37	16	54966719	54966719	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr16:54966719G>A	ENST00000394636.4	+	2	896	c.559G>A	c.(559-561)Gac>Aac	p.D187N	IRX5_ENST00000558597.1_Missense_Mutation_p.D121N|IRX5_ENST00000560154.1_Intron|IRX5_ENST00000320990.5_Missense_Mutation_p.D187N			P78411	IRX5_HUMAN	iroquois homeobox 5	187	Poly-Glu.				response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|vitamin D binding			kidney(3)|large_intestine(6)|lung(4)|prostate(1)	14						CCGCAGCGAGGACGAGGAAGA	0.627000													39	80					0	0	1	0	0
PLXNB1	5364	broad.mit.edu	37	3	48461549	48461549	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:48461549G>A	ENST00000358536.4	-	11	2415	c.2146C>T	c.(2146-2148)Ccc>Tcc	p.P716S	PLXNB1_ENST00000358459.4_Intron|PLXNB1_ENST00000456774.1_Intron|PLXNB1_ENST00000296440.6_Missense_Mutation_p.P716S|PLXNB1_ENST00000448774.2_Intron	NM_002673.4	NP_002664.2	O43157	PLXB1_HUMAN	plexin B1	716	Pro-rich.				axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GCTGTGGAGGGAGCCCCAGGC	0.672000													5	11					0	0	1	0	0
BPIFB3	359710	broad.mit.edu	37	20	31643271	31643271	+	Silent	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr20:31643271C>G	ENST00000375494.3	+	1	42	c.42C>G	c.(40-42)ctC>ctG	p.L14L		NM_182658.1	NP_872599.1	P59826	LPLC3_HUMAN	BPI fold containing family B, member 3	14	Leu-rich.				innate immune response	cytoplasm|extracellular region	lipid binding|protein binding										TGCTTCTGCTCTGGGGCCTGG	0.607000													24	72					0	0	1	0	0
PTGIS	5740	broad.mit.edu	37	20	48129776	48129776	+	Silent	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr20:48129776G>C	ENST00000244043.4	-	8	1076	c.1047C>G	c.(1045-1047)ctC>ctG	p.L349L	PTGIS_ENST00000478971.1_5'UTR	NM_000961.3	NP_000952.1	Q16647	PTGIS_HUMAN	prostaglandin I2 (prostacyclin) synthase	349					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|prostaglandin-I synthase activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(6)|ovary(3)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	27			BRCA - Breast invasive adenocarcinoma(12;2.37e-05)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)		Phenylbutazone(DB00812)	CTGTAAGCCTGAGGCTCTCAC	0.592000													10	24					0	0	1	0	0
OBSL1	23363	broad.mit.edu	37	2	220429983	220429983	+	Silent	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr2:220429983G>A	ENST00000404537.1	-	6	2444	c.2388C>T	c.(2386-2388)ttC>ttT	p.F796F	OBSL1_ENST00000373876.1_Silent_p.F796F|OBSL1_ENST00000373873.4_Silent_p.F796F|OBSL1_ENST00000603926.1_Silent_p.F796F|OBSL1_ENST00000265318.4_Silent_p.F796F|OBSL1_ENST00000289656.3_Silent_p.F383F	NM_015311.2	NP_056126.1	O75147	OBSL1_HUMAN	obscurin-like 1	796	Ig-like 5.				cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity						Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		TGACGCCGAAGAAGGCCGAGA	0.607000													4	15					0	0	1	0	0
LMO7	4008	broad.mit.edu	37	13	76381694	76381694	+	Silent	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr13:76381694C>G	ENST00000357063.3	+	11	2691	c.1431C>G	c.(1429-1431)ccC>ccG	p.P477P	LMO7_ENST00000321797.8_Silent_p.P192P|LMO7_ENST00000465261.2_Silent_p.P192P|LMO7_ENST00000526202.1_Intron|LMO7_ENST00000377534.3_Silent_p.P477P|LMO7_ENST00000341547.4_Intron			Q8WWI1	LMO7_HUMAN	LIM domain 7	477						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(20)|lung(15)|ovary(2)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		AAATTGATCCCACTTCTGGCC	0.468000													8	19					0	0	1	0	0
MAGEB10	139422	broad.mit.edu	37	X	27839490	27839490	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chrX:27839490G>A	ENST00000356790.2	+	3	312	c.67G>A	c.(67-69)Gaa>Aaa	p.E23K		NM_182506.3	NP_872312.2	Q96LZ2	MAGBA_HUMAN	melanoma antigen family B, 10	23										NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	26						AGGAGGGCTGGAAGATTTGAT	0.512000													9	9					0	0	1	0	0
GRIP2	80852	broad.mit.edu	37	3	14564571	14564571	+	RNA	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:14564571C>T	ENST00000273083.3	-	0	567							Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2						synaptic transmission	cytosol|plasma membrane	protein binding			endometrium(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	25						TGCCCATCTTCATGGGCACCT	0.612000													13	58					0	0	1	0	0
ZNF800	168850	broad.mit.edu	37	7	127015047	127015047	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr7:127015047C>T	ENST00000393313.1	-	5	934	c.343G>A	c.(343-345)Gat>Aat	p.D115N	ZNF800_ENST00000393312.1_Missense_Mutation_p.D115N|ZNF800_ENST00000265827.3_Missense_Mutation_p.D115N			Q2TB10	ZN800_HUMAN	zinc finger protein 800	115					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(8)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	32						TCTAGGAGATCATTTATGGCT	0.328000													8	10					0	0	1	0	0
TRIM28	10155	broad.mit.edu	37	19	59059491	59059491	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr19:59059491G>A	ENST00000253024.5	+	7	1334	c.1045G>A	c.(1045-1047)Gcc>Acc	p.A349T	TRIM28_ENST00000341753.6_Missense_Mutation_p.A267T	NM_005762.2	NP_005753.1	Q13263	TIF1B_HUMAN	tripartite motif containing 28	349	Leucine zipper alpha helical coiled-coil region.|RBCC domain.				epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent	nucleoplasm	chromo shadow domain binding|ligase activity|transcription corepressor activity|zinc ion binding			biliary_tract(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|urinary_tract(1)	19		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)		TCTGCGCTTTGCCTCTTGGGC	0.577000													40	112					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34383868	34383868	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr1:34383868C>A	ENST00000373381.4	-	5	923	c.747G>T	c.(745-747)caG>caT	p.Q249H		NM_001281956.1|NM_052896.3	NP_001268885.1|NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	209	CUB 2.					integral to membrane|plasma membrane	protein binding	p.Q209H(1)		NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TGATGCCACTCTGGCCCCGCA	0.592000													4	17					1.23904e-05	1.28967e-05	1	1	0
VTI1B	10490	broad.mit.edu	37	14	68118155	68118155	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr14:68118155C>G	ENST00000554659.1	-	6	987	c.646G>C	c.(646-648)Gag>Cag	p.E216Q	ARG2_ENST00000261783.3_3'UTR	NM_006370.2	NP_006361.1	Q9UEU0	VTI1B_HUMAN	vesicle transport through interaction with t-SNAREs 1B	216					cell proliferation|cellular membrane fusion|intracellular protein transport|vesicle docking involved in exocytosis	endomembrane system|integral to membrane				endometrium(1)|large_intestine(2)|stomach(1)|upper_aerodigestive_tract(1)	5				all cancers(60;0.000344)|OV - Ovarian serous cystadenocarcinoma(108;0.00212)|BRCA - Breast invasive adenocarcinoma(234;0.00941)		ATGGCGAGCTCCAGTAAGATG	0.443000													14	43					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38595906	38595906	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:38595906G>C	ENST00000413689.1	-	27	4870	c.4677C>G	c.(4675-4677)atC>atG	p.I1559M	SCN5A_ENST00000449557.2_Missense_Mutation_p.I1505M|SCN5A_ENST00000333535.4_Missense_Mutation_p.I1559M|SCN5A_ENST00000451551.2_Missense_Mutation_p.I1505M|SCN5A_ENST00000423572.2_Missense_Mutation_p.I1558M|SCN5A_ENST00000414099.2_Missense_Mutation_p.I1541M|SCN5A_ENST00000455624.2_Missense_Mutation_p.I1558M|SCN5A_ENST00000443581.1_Missense_Mutation_p.I1558M|SCN5A_ENST00000450102.2_Missense_Mutation_p.I1505M|SCN5A_ENST00000464652.1_5'UTR|SCN5A_ENST00000425664.1_Missense_Mutation_p.I1541M	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	1559					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	TCTTGGCCAAGATGTTGATTT	0.488000													19	51					0	0	1	0	0
UBLCP1	134510	broad.mit.edu	37	5	158696038	158696038	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr5:158696038C>T	ENST00000296786.6	+	2	441	c.115C>T	c.(115-117)Ctt>Ttt	p.L39F		NM_145049.3	NP_659486.2	Q8WVY7	UBCP1_HUMAN	ubiquitin-like domain containing CTD phosphatase 1	39	Ubiquitin-like.					nucleus	phosphoprotein phosphatase activity			endometrium(1)|kidney(3)|large_intestine(4)|ovary(1)	9	Renal(175;0.00196)	Medulloblastoma(196;0.0523)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TACAGGAGTTCTTCCAGAACG	0.368000													11	31					0	0	1	0	0
ZNF800	168850	broad.mit.edu	37	7	127014801	127014801	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr7:127014801C>G	ENST00000393313.1	-	5	1180	c.589G>C	c.(589-591)Gag>Cag	p.E197Q	ZNF800_ENST00000393312.1_Missense_Mutation_p.E197Q|ZNF800_ENST00000265827.3_Missense_Mutation_p.E197Q			Q2TB10	ZN800_HUMAN	zinc finger protein 800	197					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(8)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	32						GTAACAATCTCAACAGGAGGG	0.443000													13	43					0	0	1	0	0
ERAP1	51752	broad.mit.edu	37	5	96136617	96136617	+	Nonsense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr5:96136617G>C	ENST00000296754.3	-	3	868	c.611C>G	c.(610-612)tCa>tGa	p.S204*	ERAP1_ENST00000443439.2_Nonsense_Mutation_p.S204*	NM_016442.3	NP_057526.3	Q9NZ08	ERAP1_HUMAN	endoplasmic reticulum aminopeptidase 1	204					angiogenesis|antigen processing and presentation of endogenous peptide antigen via MHC class I|fat cell differentiation|membrane protein ectodomain proteolysis|regulation of blood pressure|regulation of innate immune response|response to bacterium	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region|integral to membrane	aminopeptidase activity|interleukin-1, Type II receptor binding|interleukin-6 receptor binding|metalloexopeptidase activity|zinc ion binding			endometrium(7)|large_intestine(5)|lung(3)|ovary(1)|pancreas(1)|stomach(2)	19		all_cancers(142;1.75e-06)|all_epithelial(76;3.08e-09)|all_lung(232;0.000435)|Lung NSC(167;0.000601)|Ovarian(225;0.024)|Colorectal(57;0.0432)|Breast(839;0.244)		all cancers(79;7.26e-15)|COAD - Colon adenocarcinoma(37;0.071)		AATTTTGATTGAGAAACTTGC	0.413000													6	27					0	0	1	0	0
ALPK3	57538	broad.mit.edu	37	15	85383866	85383866	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr15:85383866C>T	ENST00000258888.5	+	5	2129	c.1962C>T	c.(1960-1962)ctC>ctT	p.L654L		NM_020778.4	NP_065829.3	Q96L96	ALPK3_HUMAN	alpha-kinase 3	654					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			NS(3)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(4)|large_intestine(9)|lung(27)|ovary(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	81			BRCA - Breast invasive adenocarcinoma(143;0.0587)			AGGCACCCCTCAGGGCTAGAA	0.652000													16	31					0	0	1	0	0
TIRAP	114609	broad.mit.edu	37	11	126162883	126162883	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr11:126162883C>T	ENST00000392679.1	+	4	862	c.579C>T	c.(577-579)ttC>ttT	p.F193F	TIRAP_ENST00000392680.2_Silent_p.F193F|TIRAP_ENST00000392678.3_Silent_p.F193F|RP11-712L6.7_ENST00000533378.1_RNA			P58753	TIRAP_HUMAN	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	193	TIR.				3'-UTR-mediated mRNA stabilization|cellular response to bacterial lipopeptide|cellular response to lipoteichoic acid|defense response to Gram-positive bacterium|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|myeloid cell differentiation|negative regulation of growth of symbiont in host|positive regulation of B cell proliferation|positive regulation of chemokine (C-X-C motif) ligand 1 production|positive regulation of chemokine (C-X-C motif) ligand 2 production|positive regulation of ERK1 and ERK2 cascade|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-12 production|positive regulation of interleukin-15 production|positive regulation of interleukin-6 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of JNK cascade|positive regulation of neutrophil chemotaxis|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein homodimerization activity|positive regulation of toll-like receptor 2 signaling pathway|positive regulation of toll-like receptor 3 signaling pathway|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of tumor necrosis factor production|regulation of interferon-beta production|response to lipopolysaccharide|TIRAP-dependent toll-like receptor 4 signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway	endocytic vesicle|intrinsic to membrane|ruffle membrane	phosphatidylinositol-4,5-bisphosphate binding|protein binding, bridging|protein heterodimerization activity|protein homodimerization activity|protein kinase C delta binding|Toll-like receptor 2 binding|Toll-like receptor 4 binding|transmembrane receptor activity			breast(1)|endometrium(1)|large_intestine(2)|ovary(1)|upper_aerodigestive_tract(1)	6	all_hematologic(175;0.145)	Breast(109;0.00156)|Lung NSC(97;0.00948)|all_lung(97;0.0101)|Medulloblastoma(222;0.0425)|all_neural(223;0.0604)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0739)		AGCTCCGATTCATGTACTACG	0.612000													6	32					0	0	1	0	0
ACTN4	81	broad.mit.edu	37	19	39195575	39195575	+	Splice_Site	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr19:39195575G>C	ENST00000252699.2	+	4	475	c.399G>C	c.(397-399)gaG>gaC	p.E133D	ACTN4_ENST00000390009.3_Intron|ACTN4_ENST00000424234.2_Intron	NM_004924.4	NP_004915.2	O43707	ACTN4_HUMAN	actinin, alpha 4	133	Actin-binding.|CH 1.				platelet activation|platelet degranulation|positive regulation of cellular component movement|positive regulation of sodium:hydrogen antiporter activity|protein transport|regulation of apoptosis	extracellular region|nucleolus|perinuclear region of cytoplasm|platelet alpha granule lumen|protein complex|pseudopodium|ribonucleoprotein complex	actin filament binding|calcium ion binding|integrin binding|nucleoside binding|protein homodimerization activity			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|urinary_tract(3)	30	all_cancers(60;1.57e-05)|Ovarian(47;0.103)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			TGTGTGCAGAGATTGTGGACG	0.567000													8	29					0	0	1	0	0
FAM86C2P	645332	broad.mit.edu	37	11	67560711	67560711	+	RNA	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr11:67560711G>A	ENST00000528089.1	-	0	1039																											TCTTCGTAGGGAAACAGTTTC	0.512000													26	71					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11511499	11511499	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr17:11511499G>A	ENST00000262442.4	+	2	539	c.471G>A	c.(469-471)atG>atA	p.M157I	DNAH9_ENST00000454412.2_Missense_Mutation_p.M157I|DNAH9_ENST00000579828.1_Missense_Mutation_p.M157I	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9		Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GGCCCCACATGATATGTGAGG	0.512000													37	120					0	0	1	0	0
C19orf26	255057	broad.mit.edu	37	19	1235034	1235034	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr19:1235034C>T	ENST00000590083.1	-	5	713	c.421G>A	c.(421-423)Gag>Aag	p.E141K	C19orf26_ENST00000382477.2_Missense_Mutation_p.E135K|C19orf26_ENST00000215376.6_Missense_Mutation_p.E135K			Q8N350	DOS_HUMAN	chromosome 19 open reading frame 26	135						integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)	9		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGGCTCTGCTCAAACAGCGCC	0.706000										HNSCC(14;0.022)			7	16					0	0	1	0	0
TAF5L	27097	broad.mit.edu	37	1	229738101	229738101	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr1:229738101C>T	ENST00000366675.3	-	4	901	c.813G>A	c.(811-813)ttG>ttA	p.L271L	TAF5L_ENST00000258281.2_Silent_p.L271L|TAF5L_ENST00000366676.1_Silent_p.L271L	NM_001025247.1	NP_001020418.1	O75529	TAF5L_HUMAN	TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa	271					histone H3 acetylation|transcription from RNA polymerase II promoter	STAGA complex|transcription factor TFTC complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|lung(4)|ovary(1)	11	Breast(184;0.193)|Ovarian(103;0.249)	Prostate(94;0.167)				CTGCAGTGTTCAACAGCTGCT	0.473000													12	34					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	144991766	144991766	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr8:144991766C>G	ENST00000322810.4	-	32	12803	c.12634G>C	c.(12634-12636)Gag>Cag	p.E4212Q	PLEC_ENST00000345136.3_Missense_Mutation_p.E4075Q|PLEC_ENST00000357649.2_Missense_Mutation_p.E4079Q|PLEC_ENST00000398774.2_Missense_Mutation_p.E4043Q|PLEC_ENST00000354589.3_Missense_Mutation_p.E4075Q|PLEC_ENST00000527096.1_Missense_Mutation_p.E4098Q|PLEC_ENST00000356346.3_Missense_Mutation_p.E4061Q|PLEC_ENST00000354958.2_Missense_Mutation_p.E4053Q|PLEC_ENST00000436759.2_Missense_Mutation_p.E4102Q	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	4212	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						TCGTTCATCTCCTCATCGAAG	0.632000													13	115					0	0	1	0	0
EPHA5	2044	broad.mit.edu	37	4	66467514	66467514	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr4:66467514G>A	ENST00000273854.3	-	3	1355	c.755C>T	c.(754-756)tCt>tTt	p.S252F	EPHA5_ENST00000432638.2_Missense_Mutation_p.S252F|EPHA5_ENST00000511294.1_Missense_Mutation_p.S252F|EPHA5_ENST00000354839.4_Missense_Mutation_p.S252F	NM_001281765.1|NM_004439.5	NP_001268694.1|NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	252	Cys-rich.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						CAATTGGGAAGAATCAGCTCC	0.522000										TSP Lung(17;0.13)			11	24					0	0	1	0	0
RAB6B	51560	broad.mit.edu	37	3	133557045	133557045	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:133557045C>T	ENST00000285208.4	-	6	809	c.460G>A	c.(460-462)Gag>Aag	p.E154K	RAB6B_ENST00000543906.1_Missense_Mutation_p.E154K|RAB6B_ENST00000469959.1_Intron|RAB6B_ENST00000486858.1_Missense_Mutation_p.E141K	NM_016577.3	NP_057661.3	Q9NRW1	RAB6B_HUMAN	RAB6B, member RAS oncogene family	154					protein transport|retrograde vesicle-mediated transport, Golgi to ER|small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle|Golgi membrane	GTP binding|GTPase activity|protein binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|pancreas(1)	11						GCACTGGTCTCAATGAACATG	0.612000													51	105					0	0	1	0	0
TEP1	7011	broad.mit.edu	37	14	20836992	20836992	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr14:20836992C>G	ENST00000262715.5	-	54	7766	c.7726G>C	c.(7726-7728)Gat>Cat	p.D2576H	TEP1_ENST00000556935.1_Missense_Mutation_p.D2468H	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	2576					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		AGCTTAACATCTCTGTCCTTC	0.532000													3	21					0	0	1	0	0
CLRN3	119467	broad.mit.edu	37	10	129676575	129676575	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr10:129676575C>T	ENST00000368671.3	-	3	681	c.519G>A	c.(517-519)acG>acA	p.T173T		NM_152311.3	NP_689524.1	Q8NCR9	CLRN3_HUMAN	clarin 3	173						integral to membrane				endometrium(1)|large_intestine(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	6		all_epithelial(44;0.00168)|all_lung(145;0.0586)|Lung NSC(174;0.0765)|all_neural(114;0.201)|Glioma(114;0.222)|Colorectal(57;0.235)				AACTGTGGGTCGTTCCTTTAC	0.453000													33	79					0	0	1	0	0
CYP3A4	1576	broad.mit.edu	37	7	99355845	99355845	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr7:99355845G>C	ENST00000354593.2	-	8	1076	c.973C>G	c.(973-975)Ctg>Gtg	p.L325V	CYP3A4_ENST00000336411.2_Missense_Mutation_p.L475V			P08684	CP3A4_HUMAN	cytochrome P450, family 3, subfamily A, polypeptide 4	475					alkaloid catabolic process|androgen metabolic process|exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid catabolic process|xenobiotic metabolic process	cell surface|endoplasmic reticulum membrane|integral to membrane|microsome	albendazole monooxygenase activity|caffeine oxidase activity|electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding|quinine 3-monooxygenase activity|steroid binding|taurochenodeoxycholate 6alpha-hydroxylase activity|testosterone 6-beta-hydroxylase activity|vitamin D 24-hydroxylase activity|vitamin D3 25-hydroxylase activity			breast(3)|central_nervous_system(3)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|skin(2)	18	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)				Albendazole(DB00518)|Alclometasone(DB00240)|Alfentanil(DB00802)|Alfuzosin(DB00346)|Aliskiren(DB01258)|Almotriptan(DB00918)|Alosetron(DB00969)|Alprazolam(DB00404)|Amlodipine(DB00381)|Amprenavir(DB00701)|Aprepitant(DB00673)|Aripiprazole(DB01238)|Astemizole(DB00637)|Atazanavir(DB01072)|Atorvastatin(DB01076)|Benazepril(DB00542)|Bepridil(DB01244)|Betamethasone(DB00443)|Bexarotene(DB00307)|Bortezomib(DB00188)|Bosentan(DB00559)|Bromocriptine(DB01200)|Budesonide(DB01222)|Bupivacaine(DB00297)|Buprenorphine(DB00921)|Buspirone(DB00490)|Busulfan(DB01008)|Carbamazepine(DB00564)|Cevimeline(DB00185)|Chlorpheniramine(DB01114)|Ciclesonide(DB01410)|Cilostazol(DB01166)|Cinacalcet(DB01012)|Cisapride(DB00604)|Clarithromycin(DB01211)|Clindamycin(DB01190)|Clofibrate(DB00636)|Clonazepam(DB01068)|Clopidogrel(DB00758)|Cocaine(DB00907)|Conivaptan(DB00872)|Conjugated Estrogens(DB00286)|Cyproterone(DB04839)|Darifenacin(DB00496)|Darunavir(DB01264)|Dasatinib(DB01254)|Delavirdine(DB00705)|Desogestrel(DB00304)|Dexamethasone(DB01234)|Diazepam(DB00829)|Dihydroergotamine(DB00320)|Diltiazem(DB00343)|Diphenhydramine(DB01075)|Disopyramide(DB00280)|Dofetilide(DB00204)|Dolasetron(DB00757)|Domperidone(DB01184)|Donepezil(DB00843)|Doxorubicin(DB00997)|Drospirenone(DB01395)|Dutasteride(DB01126)|Efavirenz(DB00625)|Eletriptan(DB00216)|Enalapril(DB00584)|Epirubicin(DB00445)|Eplerenone(DB00700)|Ergotamine(DB00696)|Erlotinib(DB00530)|Erythromycin(DB00199)|Escitalopram(DB01175)|Esomeprazole(DB00736)|Estazolam(DB01215)|Eszopiclone(DB00402)|Ethinyl Estradiol(DB00977)|Ethosuximide(DB00593)|Etonogestrel(DB00294)|Etoposide(DB00773)|Etoricoxib(DB01628)|Exemestane(DB00990)|Felodipine(DB01023)|Fentanyl(DB00813)|Fexofenadine(DB00950)|Finasteride(DB01216)|Fluconazole(DB00196)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Fosamprenavir(DB01319)|Fulvestrant(DB00947)|Galantamine(DB00674)|Gefitinib(DB00317)|Gemfibrozil(DB01241)|Granisetron(DB00889)|Grepafloxacin(DB00365)|Halofantrine(DB01218)|Hydrocodone(DB00956)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Hydromorphone(DB00327)|Imatinib(DB00619)|Indinavir(DB00224)|Ipratropium(DB00332)|Irinotecan(DB00762)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Isradipine(DB00270)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lercanidipine(DB00528)|Letrozole(DB01006)|Levobupivacaine(DB01002)|Levomethadyl Acetate(DB01227)|Levothyroxine(DB00451)|Lomustine(DB01206)|Loperamide(DB00836)|Lopinavir(DB01601)|Loratadine(DB00455)|Losartan(DB00678)|Lovastatin(DB00227)|Maraviroc(DB04835)|Marinol(DB00470)|Mebendazole(DB00643)|Medroxyprogesterone(DB00603)|Methadone(DB00333)|Methylprednisolone(DB00959)|Metyrapone(DB01011)|Mibefradil(DB01388)|Midazolam(DB00683)|Mifepristone(DB00834)|Mirtazapine(DB00370)|Modafinil(DB00745)|Mometasone(DB00764)|Montelukast(DB00471)|Nateglinide(DB00731)|Nefazodone(DB01149)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicardipine(DB00622)|Nifedipine(DB01115)|Nimodipine(DB00393)|Nisoldipine(DB00401)|Nitrendipine(DB01054)|Norethindrone(DB00717)|Norgestrel(DB00506)|Nystatin(DB00646)|Ondansetron(DB00904)|Oxybutynin(DB01062)|Paclitaxel(DB01229)|Paliperidone(DB01267)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Paricalcitol(DB00910)|Phenmetrazine(DB00830)|Pimecrolimus(DB00337)|Pimozide(DB01100)|Pioglitazone(DB01132)|Posaconazole(DB01263)|Pranlukast(DB01411)|Prednisolone(DB00860)|Prednisone(DB00635)|Prochlorperazine(DB00433)|Quetiapine(DB01224)|Quinapril(DB00881)|Quinine(DB00468)|Rabeprazole(DB01129)|Ranolazine(DB00243)|Reboxetine(DB00234)|Retapamulin(DB01256)|Rifabutin(DB00615)|Rifampin(DB01045)|Rimonabant(DB06155)|Ritonavir(DB00503)|Rofecoxib(DB00533)|Roxithromycin(DB00778)|Salmeterol(DB00938)|Saquinavir(DB01232)|Sertindole(DB06144)|Sibutramine(DB01105)|Simvastatin(DB00641)|Sirolimus(DB00877)|Sitagliptin(DB01261)|Solifenacin(DB01591)|Sorafenib(DB00398)|Sunitinib(DB01268)|Tacrolimus(DB00864)|Tadalafil(DB00820)|Tamoxifen(DB00675)|Telithromycin(DB00976)|Terconazole(DB00251)|Terfenadine(DB00342)|Testosterone(DB00624)|Tiagabine(DB00906)|Ticlopidine(DB00208)|Tinidazole(DB00911)|Tiotropium(DB01409)|Tipranavir(DB00932)|Toremifene(DB00539)|Triazolam(DB00897)|Trimetrexate(DB01157)|Troglitazone(DB00197)|Valdecoxib(DB00580)|Vardenafil(DB00862)|Vinblastine(DB00570)|Vincristine(DB00541)|Vindesine(DB00309)|Vinorelbine(DB00361)|Voriconazole(DB00582)|Zaleplon(DB00962)|Zileuton(DB00744)|Ziprasidone(DB00246)|Zolpidem(DB00425)|Zonisamide(DB00909)	CTTAATTTCAGGGGGATCTGC	0.403000													4	21					0	0	1	0	0
CHD6	84181	broad.mit.edu	37	20	40116392	40116392	+	Silent	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr20:40116392G>A	ENST00000373233.3	-	14	2091	c.1914C>T	c.(1912-1914)ttC>ttT	p.F638F	CHD6_ENST00000309279.7_Intron	NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	638	Helicase ATP-binding.				chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				TTAACAAACTGAAGAGCTCCT	0.448000													18	40					0	0	1	0	0
NCOA3	8202	broad.mit.edu	37	20	46279860	46279860	+	Silent	SNP	G	G	A	rs151060280	byFrequency	TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr20:46279860G>A	ENST00000372004.3	+	20	3990	c.3774G>A	c.(3772-3774)caG>caA	p.Q1258Q	NCOA3_ENST00000371998.3_Silent_p.Q1262Q|NCOA3_ENST00000371997.3_Silent_p.Q1253Q|NCOA3_ENST00000341724.6_Silent_p.Q1188Q	NM_001174087.1|NM_001174088.1|NM_006534.3|NM_181659.2	NP_001167558.1|NP_001167559.1|NP_006525.2|NP_858045.1	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3	1262	Acetyltransferase.|Poly-Gln.				androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding	p.Q1262Q(1)		breast(3)|endometrium(3)|kidney(4)|large_intestine(12)|lung(19)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						agcagcagcagcagcaacagc	0.567000													4	29					0	0	1	0	0
RABIF	5877	broad.mit.edu	37	1	202850297	202850297	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr1:202850297C>T	ENST00000367262.3	-	2	217	c.181G>A	c.(181-183)Gac>Aac	p.D61N		NM_002871.4	NP_002862.2	P47224	MSS4_HUMAN	RAB interacting factor	61					cellular membrane fusion|protein transport|small GTPase mediated signal transduction		guanyl-nucleotide exchange factor activity|zinc ion binding			large_intestine(1)|lung(2)|ovary(1)	4			BRCA - Breast invasive adenocarcinoma(75;0.166)			AGATCGCCGTCAGGATTGCTG	0.507000													11	21					0	0	1	0	0
AMOTL2	51421	broad.mit.edu	37	3	134079118	134079118	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:134079118C>G	ENST00000514516.1	-	7	2065	c.1887G>C	c.(1885-1887)caG>caC	p.Q629H	AMOTL2_ENST00000513145.1_Missense_Mutation_p.Q569H|AMOTL2_ENST00000249883.5_Missense_Mutation_p.Q571H|AMOTL2_ENST00000422605.2_Missense_Mutation_p.Q571H	NM_001278683.1	NP_001265612.1	Q9Y2J4	AMOL2_HUMAN	angiomotin like 2	571										endometrium(8)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	19						CCAAATACTTCTGCTCCCACT	0.607000													4	25					0	0	1	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5146314	5146314	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr5:5146314C>T	ENST00000274181.7	+	3	385	c.247C>T	c.(247-249)Cag>Tag	p.Q83*	ADAMTS16_ENST00000511368.1_Nonsense_Mutation_p.Q83*|CTD-2297D10.1_ENST00000514848.1_RNA	NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16	83					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						CATGCACCATCAGCGGCGGAG	0.542000													9	30					0	0	1	0	0
ABCB11	8647	broad.mit.edu	37	2	169828485	169828485	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr2:169828485C>T	ENST00000263817.6	-	14	1634	c.1510G>A	c.(1510-1512)Gag>Aag	p.E504K		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	504	ABC transporter 1.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	AGAACTGGCTCTTGCTCCACT	0.483000													11	22					0	0	1	0	0
NEURL1	9148	broad.mit.edu	37	10	105331530	105331530	+	Silent	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr10:105331530C>G	ENST00000369780.4	+	3	1009	c.600C>G	c.(598-600)ctC>ctG	p.L200L	NEURL_ENST00000369777.2_Silent_p.L183L|NEURL_ENST00000465048.1_3'UTR	NM_004210.4	NP_004201.3	O76050	NEU1A_HUMAN		200	NHR 1.				nervous system development	perinuclear region of cytoplasm	zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(4)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	17				Epithelial(162;2.12e-09)|all cancers(201;6.99e-08)|BRCA - Breast invasive adenocarcinoma(275;0.125)		CCGACCCGCTCTGGGCCCTGG	0.667000													17	45					0	0	1	0	0
PCDHB10	56126	broad.mit.edu	37	5	140573047	140573047	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr5:140573047G>C	ENST00000239446.4	+	1	1106	c.922G>C	c.(922-924)Gat>Cat	p.D308H		NM_018930.3	NP_061753.1	Q9UN67	PCDBA_HUMAN		308	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(30)|ovary(4)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	76			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGAATTGCTTGATTATGAGTT	0.368000													7	26					0	0	1	0	0
EPHA2	1969	broad.mit.edu	37	1	16460021	16460021	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr1:16460021C>A	ENST00000358432.5	-	10	1973	c.1819G>T	c.(1819-1821)Gag>Tag	p.E607*		NM_004431.3	NP_004422.2	P29317	EPHA2_HUMAN	EPH receptor A2	607	Mediates interaction with ARHGEF16 and ELMO2.				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	42		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	GGATGGATCTCGGTAGTGAAC	0.592000													8	25					0.000157383	0.000162071	1	1	0
NCOA3	8202	broad.mit.edu	37	20	46264434	46264434	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr20:46264434C>T	ENST00000372004.3	+	11	1697	c.1481C>T	c.(1480-1482)tCa>tTa	p.S494L	NCOA3_ENST00000371998.3_Missense_Mutation_p.S494L|NCOA3_ENST00000371997.3_Missense_Mutation_p.S504L|NCOA3_ENST00000341724.6_Missense_Mutation_p.S504L	NM_001174087.1|NM_001174088.1|NM_006534.3|NM_181659.2	NP_001167558.1|NP_001167559.1|NP_006525.2|NP_858045.1	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3	494					androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			breast(3)|endometrium(3)|kidney(4)|large_intestine(12)|lung(19)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						AAGATAGCCTCACATCAGTTT	0.388000													12	38					0	0	1	0	0
PLVAP	83483	broad.mit.edu	37	19	17476730	17476730	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr19:17476730C>T	ENST00000252590.4	-	3	605	c.544G>A	c.(544-546)Gat>Aat	p.D182N		NM_031310.1	NP_112600.1	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	182						caveola|integral to membrane|perinuclear region of cytoplasm				cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						CTTTCCTTATCCTTAGTGCAA	0.537000													11	29					0	0	1	0	0
SCNM1	79005	broad.mit.edu	37	1	151141532	151141532	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr1:151141532G>A	ENST00000368905.4	+	7	775	c.664G>A	c.(664-666)Gag>Aag	p.E222K		NM_001204856.1|NM_024041.3	NP_001191785.1|NP_076946.1	Q9BWG6	SCNM1_HUMAN	sodium channel modifier 1	222					mRNA processing|RNA splicing	nucleus	metal ion binding|protein binding			breast(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	17	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CTCTGATGAGGAGGAACCACC	0.428000													15	33					0	0	1	0	0
UBE2C	11065	broad.mit.edu	37	20	44442086	44442086	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr20:44442086G>A	ENST00000356455.4	+	2	232	c.112G>A	c.(112-114)Gag>Aag	p.E38K	UBE2C_ENST00000405520.1_5'UTR|UBE2C_ENST00000335046.3_Missense_Mutation_p.E38K|UBE2C_ENST00000372568.4_5'UTR|UBE2C_ENST00000243893.6_Missense_Mutation_p.E38K|UBE2C_ENST00000352551.5_Missense_Mutation_p.E38K	NM_007019.2	NP_008950.1	O00762	UBE2C_HUMAN	ubiquitin-conjugating enzyme E2C	38					activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cyclin catabolic process|exit from mitosis|free ubiquitin chain polymerization|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|positive regulation of exit from mitosis|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|protein K48-linked ubiquitination|spindle organization	anaphase-promoting complex|cytosol|nucleoplasm	ATP binding|protein binding|ubiquitin-protein ligase activity			large_intestine(2)|lung(2)|skin(1)	5		Myeloproliferative disorder(115;0.0122)				GCTACAGCAGGAGCTGATGAC	0.522000													42	103					0	0	1	0	0
BARD1	580	broad.mit.edu	37	2	215634032	215634032	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr2:215634032T>C	ENST00000260947.4	-	5	1453	c.1319A>G	c.(1318-1320)gAc>gGc	p.D440G	BARD1_ENST00000449967.2_Missense_Mutation_p.D296G	NM_000465.2|NM_001282543.1|NM_001282545.1|NM_001282548.1	NP_000456.2|NP_001269472.1|NP_001269474.1|NP_001269477.1	Q99728	BARD1_HUMAN	BRCA1 associated RING domain 1	440					cell cycle arrest|DNA repair|negative regulation of apoptosis|negative regulation of mRNA 3'-end processing|negative regulation of protein export from nucleus|positive regulation of apoptosis|positive regulation of protein catabolic process|protein K6-linked ubiquitination|regulation of phosphorylation|tissue homeostasis	BRCA1-A complex|BRCA1-BARD1 complex|cytoplasm	kinase binding|protein heterodimerization activity|protein homodimerization activity|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			NS(2)|breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(14)|prostate(4)|upper_aerodigestive_tract(1)	35		Renal(323;0.0243)		Epithelial(149;3.2e-06)|all cancers(144;0.000461)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		AGAAGGTATGTCGCCCTAGAA	0.328000									Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				8	8					0	0	1	0	0
OLFML1	283298	broad.mit.edu	37	11	7507225	7507225	+	Missense_Mutation	SNP	G	G	C	rs144696887		TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr11:7507225G>C	ENST00000329293.3	+	1	513	c.119G>C	c.(118-120)cGa>cCa	p.R40P	OLFML1_ENST00000530135.1_Missense_Mutation_p.R40P|CTD-2516F10.2_ENST00000530201.1_RNA|OLFML1_ENST00000528758.1_Missense_Mutation_p.R40P	NM_198474.3	NP_940876.2	Q6UWY5	OLFL1_HUMAN	olfactomedin-like 1	40						extracellular region				breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(8)|ovary(3)|prostate(2)	24				Epithelial(150;6.96e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		CAGCGCTTTCGAGTCTTGGAG	0.502000													11	32					0	0	1	0	0
ZSCAN2	54993	broad.mit.edu	37	15	85164843	85164843	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr15:85164843C>T	ENST00000448803.2	+	3	1709	c.1417C>T	c.(1417-1419)Ccc>Tcc	p.P473S	ZSCAN2_ENST00000485222.2_Intron|ZSCAN2_ENST00000541040.1_Intron|ZSCAN2_ENST00000358472.3_Missense_Mutation_p.P323S|ZSCAN2_ENST00000538076.1_Intron|ZSCAN2_ENST00000327179.6_Missense_Mutation_p.P472S|ZSCAN2_ENST00000546148.1_Missense_Mutation_p.P473S	NM_181877.3	NP_870992.2	Q7Z7L9	ZSCA2_HUMAN	zinc finger and SCAN domain containing 2	473					cell differentiation|multicellular organismal development|spermatogenesis|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(7)|liver(2)|lung(4)|ovary(1)|pancreas(1)	19				UCEC - Uterine corpus endometrioid carcinoma (272;0.168)|all cancers(203;5.43e-22)		AGGGGAGAAACCCTACGAGTG	0.567000													9	33					0	0	1	0	0
SRD5A3	79644	broad.mit.edu	37	4	56230312	56230312	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr4:56230312G>A	ENST00000264228.4	+	3	664	c.436G>A	c.(436-438)Gag>Aag	p.E146K	SRD5A3-AS1_ENST00000433175.2_RNA|SRD5A3_ENST00000514398.1_3'UTR	NM_024592.4	NP_078868.1	Q9H8P0	PORED_HUMAN	steroid 5 alpha-reductase 3	146					androgen biosynthetic process|dolichol metabolic process|dolichol-linked oligosaccharide biosynthetic process|polyprenol catabolic process	endoplasmic reticulum membrane|integral to membrane	3-oxo-5-alpha-steroid 4-dehydrogenase activity|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor			cervix(1)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	12	all_cancers(7;0.0308)|all_lung(4;0.00195)|Lung NSC(11;0.00431)|all_epithelial(27;0.0425)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.0179)			AAGACTCTTCGAGTGCCTCTA	0.483000													17	50					0	0	1	0	0
MST1R	4486	broad.mit.edu	37	3	49941018	49941018	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr3:49941018G>A	ENST00000296474.3	-	1	52	c.25C>T	c.(25-27)Cag>Tag	p.Q9*	CTD-2330K9.2_ENST00000435478.1_RNA|MST1R_ENST00000344206.4_Nonsense_Mutation_p.Q9*	NM_002447.2	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)	9					cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			cervix(1)|endometrium(5)|large_intestine(3)|lung(17)|ovary(5)|prostate(2)|skin(1)|urinary_tract(3)	37				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		AGGAAGGACTGAGGCAGCGGC	0.716000													23	42					0	0	1	0	0
RPGRIP1	57096	broad.mit.edu	37	14	21795862	21795862	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr14:21795862C>T	ENST00000206660.6	+	17	2791	c.2791C>T	c.(2791-2793)Ccc>Tcc	p.P931S	RPGRIP1_ENST00000307974.4_Missense_Mutation_p.P290S|RPGRIP1_ENST00000556336.1_Missense_Mutation_p.P588S|RPGRIP1_ENST00000557771.1_Missense_Mutation_p.P893S|RPGRIP1_ENST00000400017.2_Missense_Mutation_p.P931S|RPGRIP1_ENST00000382933.4_Missense_Mutation_p.P257S			Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator interacting protein 1	931					response to stimulus|visual perception	cilium				breast(3)|endometrium(2)|kidney(4)|large_intestine(11)|lung(10)|ovary(4)|pancreas(1)|prostate(3)|stomach(1)	39	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		TCCCTACATACCCCCTGAGAG	0.443000													6	22					0	0	1	0	0
PPM1D	8493	broad.mit.edu	37	17	58677815	58677815	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr17:58677815G>A	ENST00000305921.3	+	1	272	c.40G>A	c.(40-42)Gac>Aac	p.D14N		NM_003620.3	NP_003611.1	O15297	PPM1D_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1D	14	Interaction with CHEK1.				negative regulation of cell proliferation|protein dephosphorylation|response to radiation	nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein binding|protein serine/threonine phosphatase activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	15	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;6.75e-12)|all cancers(12;1.96e-10)			CGTCTTCTCCGACCAGGGCGG	0.677000													2	2					0	0	1	0	0
EIF2AK4	440275	broad.mit.edu	37	15	40241358	40241358	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr15:40241358C>T	ENST00000263791.5	+	4	445	c.402C>T	c.(400-402)ctC>ctT	p.L134L	EIF2AK4_ENST00000382727.2_Silent_p.L134L|EIF2AK4_ENST00000559624.1_Silent_p.L134L	NM_001013703.2	NP_001013725.2	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha kinase 4	134	RWD.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)	40		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		AGTCATTTCTCAGCGAGCATA	0.478000													29	92					0	0	1	0	0
PALB2	79728	broad.mit.edu	37	16	23641272	23641272	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr16:23641272G>C	ENST00000261584.4	-	5	2355	c.2203C>G	c.(2203-2205)Cca>Gca	p.P735A		NM_024675.3	NP_078951.2	Q86YC2	PALB2_HUMAN	partner and localizer of BRCA2	735					double-strand break repair via homologous recombination	nucleoplasm	DNA binding|protein binding			breast(5)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(21)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(3)	55				GBM - Glioblastoma multiforme(48;0.0167)		CCAAAGGCTGGAGTAGTACCT	0.458000			"""F, N, Mis"""			"""Wilms tumor, medulloblastoma, AML ,breast"""		Involved in tolerance or repair of DNA crosslinks					10	44					0	0	1	0	0
SPTBN2	6712	broad.mit.edu	37	11	66454506	66454506	+	Silent	SNP	G	G	C			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr11:66454506G>C	ENST00000533211.1	-	36	7186	c.6855C>G	c.(6853-6855)gtC>gtG	p.V2285V	SPTBN2_ENST00000309996.2_Silent_p.V2285V|SPTBN2_ENST00000529997.1_Silent_p.V2285V			O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	2285	PH.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(15)|liver(1)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	74						AATCAAAGGCGACGCTGCCCT	0.602000													32	75					0	0	1	0	0
MRPS17	51373	broad.mit.edu	37	7	56022676	56022676	+	Silent	SNP	C	C	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr7:56022676C>T	ENST00000285298.4	+	3	327	c.198C>T	c.(196-198)ctC>ctT	p.L66L	MRPS17_ENST00000426595.1_Silent_p.L161L	NM_015969.2	NP_057053.1	Q9Y2R5	RT17_HUMAN	mitochondrial ribosomal protein S17	66					translation	mitochondrial small ribosomal subunit	rRNA binding|structural constituent of ribosome			kidney(1)|large_intestine(2)|lung(4)|urinary_tract(1)	8	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TTGTGCTTCTCAGAGCTTTAC	0.443000													44	127					0	0	1	0	0
SVIL	6840	broad.mit.edu	37	10	29812539	29812539	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr10:29812539C>G	ENST00000375398.2	-	17	3453	c.3004G>C	c.(3004-3006)Gaa>Caa	p.E1002Q	SVIL_ENST00000375400.3_Missense_Mutation_p.E576Q|SVIL_ENST00000355867.4_Missense_Mutation_p.E1002Q			O95425	SVIL_HUMAN	supervillin	1002					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(24)|lung(35)|ovary(8)|prostate(2)|skin(4)|stomach(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	112		Breast(68;0.103)				TTCGCCCGTTCCAGGCTTCCT	0.517000													8	25					0	0	1	0	0
AGGF1	55109	broad.mit.edu	37	5	76332397	76332402	+	In_Frame_Del	DEL	TAGCAA	TAGCAA	-	rs9715897		TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr5:76332397_76332402delTAGCAA	ENST00000312916.7	+	4	915_920	c.533_538delTAGCAA	c.(532-540)ttagcaaca>tca	p.178_180LAT>S	AGGF1_ENST00000503538.1_3'UTR	NM_018046.4	NP_060516.2	Q8N302	AGGF1_HUMAN	angiogenic factor with G patch and FHA domains 1	178					angiogenesis|cell adhesion|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|RNA processing|vasculogenesis	extracellular region|perinuclear region of cytoplasm	eukaryotic cell surface binding|nucleic acid binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|liver(2)|lung(4)|ovary(1)|prostate(1)|skin(2)	20		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;4.51e-51)|Epithelial(54;2.2e-45)|all cancers(79;6.68e-41)		GCATCTGCATTAGCAACAGAAGATAC	0.388													12	39	---	---	---	---					
LINC00174	285908	broad.mit.edu	37	7	65842264	65842264	+	RNA	DEL	G	G	-			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr7:65842264delG	ENST00000421767.1	-	0	3468					NR_026873.1																						AGGGAAGCCTGGGGCCTACAA	0.726													2	4	---	---	---	---					
PSD3	23362	broad.mit.edu	37	8	18490295	18490296	+	Frame_Shift_Ins	INS	-	-	T			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr8:18490295_18490296insT	ENST00000440756.2	-	11	2345_2346	c.2243_2244insA	c.(2242-2244)aagfs	p.K748fs	PSD3_ENST00000523619.1_Frame_Shift_Ins_p.K681fs|PSD3_ENST00000428502.2_Frame_Shift_Ins_p.K75fs|PSD3_ENST00000327040.8_Frame_Shift_Ins_p.K746fs|PSD3_ENST00000286485.8_Frame_Shift_Ins_p.K212fs			Q9NYI0	PSD3_HUMAN	pleckstrin and Sec7 domain containing 3	747					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		CTGAGGGAGACTTTTTTTTCTC	0.366													6	3	---	---	---	---					
CTSF	8722	broad.mit.edu	37	11	66333631	66333633	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr11:66333631_66333633delCTC	ENST00000310325.5	-	6	836_838	c.727_729delGAG	c.(727-729)gagdel	p.E243del		NM_003793.3	NP_003784.2	Q9UBX1	CATF_HUMAN	cathepsin F	243					proteolysis	lysosome	cysteine-type endopeptidase activity	p.E243K(1)		endometrium(1)|large_intestine(7)|lung(8)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	19						TAGTGCGGAACTCCTCCTCTGCG	0.567													21	87	---	---	---	---					
INO80E	283899	broad.mit.edu	37	16	30016653	30016653	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr16:30016653delC	ENST00000563197.1	+	7	1642	c.625delC	c.(625-627)cccfs	p.P211fs	INO80E_ENST00000567705.1_Frame_Shift_Del_p.P194fs|INO80E_ENST00000304516.7_Frame_Shift_Del_p.P172fs	NM_173618.1	NP_775889.1	Q8NBZ0	IN80E_HUMAN	INO80 complex subunit E	211	Pro-rich.				DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex		p.T212fs*3(1)		endometrium(1)|large_intestine(2)|lung(1)|skin(1)|urinary_tract(1)	6						CCCTAAGATGCCCCCCCCCAC	0.672													2	4	---	---	---	---					
NEUROD2	4761	broad.mit.edu	37	17	37761712	37761713	+	Frame_Shift_Ins	INS	-	-	A			TCGA-FD-A5BX-01A-11D-A26M-08	TCGA-FD-A5BX-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a610bfc5-a6ef-48a3-ad50-7f332d543e91	b50de34c-aaee-4dde-a1d7-dd023ed02390	g.chr17:37761712_37761713insA	ENST00000302584.4	-	2	1360_1361	c.1140_1141insT	c.(1138-1143)tttcatfs	p.H381fs		NM_006160.3	NP_006151.3	Q15784	NDF2_HUMAN	neuronal differentiation 2	381					cellular response to calcium ion|cellular response to electrical stimulus|cerebellar cortex development|negative regulation of synapse maturation|positive regulation of calcium-mediated signaling|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of synapse maturation|positive regulation of synaptic plasticity|protein ubiquitination|regulation of transcription from RNA polymerase II promoter	nucleus	E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(4)	8	Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Lung(15;0.00549)|LUAD - Lung adenocarcinoma(14;0.0664)			TCTCAGTTATGAAAAAACGCAT	0.614													7	5	---	---	---	---