Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KCNIP2	30819	broad.mit.edu	37	10	103587157	103587157	+	Splice_Site	SNP	C	C	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:103587157C>A	ENST00000358038.3	-	9	1063	c.712G>T	c.(712-714)Gat>Tat	p.D238Y	KCNIP2_ENST00000355657.2_5'UTR|KCNIP2_ENST00000370046.1_Splice_Site_p.D170Y|KCNIP2_ENST00000343195.4_Splice_Site_p.D206Y|KCNIP2_ENST00000356640.2_Splice_Site_p.D256Y|KCNIP2_ENST00000461105.1_Splice_Site_p.D271Y|KCNIP2-AS1_ENST00000412353.1_RNA|KCNIP2_ENST00000353068.3_Splice_Site_p.D213Y|KCNIP2_ENST00000348850.5_Splice_Site_p.D211Y	NM_173192.2|NM_173193.2|NM_173195.2	NP_775284.1|NP_775285.1|NP_775287.1	Q9NS61	KCIP2_HUMAN	Kv channel interacting protein 2	256	EF-hand 4.				clustering of voltage-gated potassium channels|detection of calcium ion|muscle contraction|regulation of heart contraction|signal transduction|synaptic transmission	cytoplasm|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|calcium ion binding|ER retention sequence binding|identical protein binding|protein N-terminus binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	11		Colorectal(252;0.122)		Epithelial(162;4.93e-09)|all cancers(201;2.63e-07)		ATGTTCTCATCCTGTGGCCAT	0.522000													25	111					1.55469e-16	1.62664e-16	1	1	0
CDH23	64072	broad.mit.edu	37	10	73326687	73326687	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:73326687C>T	ENST00000224721.6	+	6	638	c.633C>T	c.(631-633)aaC>aaT	p.N211N	CDH23_ENST00000299366.7_Silent_p.N251N|CDH23_ENST00000398842.3_Silent_p.N206N|CDH23_ENST00000398809.4_Silent_p.N206N|CDH23_ENST00000461841.3_Silent_p.N251N	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	206	Cadherin 2.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						TCACGGTCAACGCCACAGTGA	0.627000													4	24					0	0	1	0	0
AFF4	27125	broad.mit.edu	37	5	132270153	132270153	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:132270153G>A	ENST00000265343.5	-	3	983	c.604C>T	c.(604-606)Cac>Tac	p.H202Y	AFF4_ENST00000378595.3_Missense_Mutation_p.H202Y|AFF4_ENST00000491831.1_5'UTR	NM_014423.3	NP_055238.1	Q9UHB7	AFF4_HUMAN	AF4/FMR2 family, member 4	202	Ser-rich.				transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity		SEPT8/AFF4(2)	breast(2)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(7)|lung(11)|ovary(3)|pancreas(1)|prostate(3)|skin(2)	43		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TTGCTATGGTGATCATTCCCA	0.488000													21	73					0	0	1	0	0
LBX2	85474	broad.mit.edu	37	2	74725261	74725261	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:74725261G>A	ENST00000460508.3	-	2	834	c.378C>T	c.(376-378)gtC>gtT	p.V126V	LBX2_ENST00000377566.4_Silent_p.V130V|LBX2_ENST00000550249.1_5'UTR|LBX2_ENST00000341396.2_3'UTR	NM_001009812.1	NP_001009812.1	Q6XYB7	LBX2_HUMAN	ladybird homeobox 2	130						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(1)	4						GGAACCAAGTGACCACCTGCG	0.667000													15	34					0	0	1	0	0
C19orf33	64073	broad.mit.edu	37	19	38795250	38795250	+	Missense_Mutation	SNP	G	G	A	rs45437199	by1000genomes	TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:38795250G>A	ENST00000588605.1	+	3	282	c.184G>A	c.(184-186)Gca>Aca	p.A62T	C19orf33_ENST00000301246.5_Intron|CTB-102L5.4_ENST00000591889.1_Silent_p.P129P			Q9GZP8	IMUP_HUMAN	chromosome 19 open reading frame 33	0						nucleus						all_cancers(60;1.07e-06)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CCTCACTGCCGCACCTCCATC	0.672000													3	17					0	0	1	0	0
PLA2R1	22925	broad.mit.edu	37	2	160824175	160824175	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:160824175C>T	ENST00000283243.7	-	20	2985	c.2779G>A	c.(2779-2781)Gaa>Aaa	p.E927K	PLA2R1_ENST00000392771.1_Missense_Mutation_p.E927K	NM_001195641.1|NM_007366.4	NP_001182570.1|NP_031392.3	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1, 180kDa	927	C-type lectin 5.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding		PLA2R1/RBMS1(2)	central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(17)|lung(20)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	60						GAACACTCTTCACTACCCCAG	0.403000													18	87					0	0	1	0	0
ABCA10	10349	broad.mit.edu	37	17	67145021	67145021	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:67145021C>T	ENST00000269081.4	-	40	5488	c.4579G>A	c.(4579-4581)Gat>Aat	p.D1527N	ABCA10_ENST00000519732.1_5'UTR|ABCA10_ENST00000416101.2_3'UTR	NM_080282.3	NP_525021.3	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 10	1527					transport	integral to membrane	ATP binding|ATPase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(34)|ovary(2)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	81	Breast(10;6.95e-12)					TCAATTTTATCATCAACATTT	0.348000													18	71					0	0	1	0	0
AKAP8L	26993	broad.mit.edu	37	19	15512157	15512157	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:15512157G>A	ENST00000397410.5	-	5	750	c.620C>T	c.(619-621)gCc>gTc	p.A207V	AKAP8L_ENST00000595465.2_Missense_Mutation_p.A146V	NM_014371.2	NP_055186.2	Q9ULX6	AKP8L_HUMAN	A kinase (PRKA) anchor protein 8-like							cytoplasm|nuclear matrix	DEAD/H-box RNA helicase binding|DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(2)|lung(1)|ovary(1)|prostate(1)|urinary_tract(1)	11						CTGGCCCCGGGCCCCCATGGG	0.692000													13	54					0	0	1	0	0
CD2AP	23607	broad.mit.edu	37	6	47544789	47544789	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:47544789G>T	ENST00000359314.5	+	8	1309	c.853G>T	c.(853-855)Gaa>Taa	p.E285*		NM_012120.2	NP_036252.1	Q9Y5K6	CD2AP_HUMAN	CD2-associated protein	285	SH3 3.				cell division|mitosis|protein complex assembly|signal transduction|substrate-dependent cell migration, cell extension	cytoplasm|filamentous actin|nucleolus|plasma membrane|ruffle	SH3 domain binding|structural constituent of cytoskeleton			kidney(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	20			Lung(136;0.105)|LUSC - Lung squamous cell carcinoma(51;0.138)			AGGTACTAATGAAGATGAACT	0.284000													11	113					3.83957e-06	3.91485e-06	1	1	0
IFNGR2	3460	broad.mit.edu	37	21	34804515	34804515	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr21:34804515C>G	ENST00000290219.6	+	5	1241	c.593C>G	c.(592-594)tCa>tGa	p.S198*	IFNGR2_ENST00000381995.1_Nonsense_Mutation_p.S217*|IFNGR2_ENST00000405436.1_Nonsense_Mutation_p.S119*	NM_005534.3	NP_005525.2	P38484	INGR2_HUMAN	interferon gamma receptor 2 (interferon gamma transducer 1)	198	Fibronectin type-III 2.				regulation of interferon-gamma-mediated signaling pathway|response to virus	endoplasmic reticulum|integral to plasma membrane	interferon-gamma receptor activity			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|urinary_tract(1)	13					Interferon gamma-1b(DB00033)	AACTCCATTTCATTGGATAAC	0.403000													7	80					0	0	1	0	0
ZNF669	79862	broad.mit.edu	37	1	247265040	247265040	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:247265040C>G	ENST00000343381.6	-	3	614	c.442G>C	c.(442-444)Gat>Cat	p.D148H	ZNF669_ENST00000358785.4_Intron|ZNF669_ENST00000448299.2_Missense_Mutation_p.D62H|ZNF669_ENST00000366501.1_Missense_Mutation_p.K60N|ZNF669_ENST00000366500.1_Intron	NM_024804.2	NP_079080.2	Q96BR6	ZN669_HUMAN	zinc finger protein 669	148	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(4)|large_intestine(2)|lung(6)	17	all_cancers(71;4.09e-05)|all_epithelial(71;6.72e-06)|Breast(184;0.0226)|Ovarian(71;0.0283)|all_lung(81;0.0488)|Lung NSC(105;0.053)		OV - Ovarian serous cystadenocarcinoma(106;0.00427)			TACCTTATATCTTTCCCAGGT	0.338000													11	55					0	0	1	0	0
ARHGEF26	26084	broad.mit.edu	37	3	153870637	153870637	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:153870637C>G	ENST00000356448.4	+	6	1687	c.1403C>G	c.(1402-1404)tCt>tGt	p.S468C	ARHGEF26_ENST00000465817.1_Intron|ARHGEF26_ENST00000465093.1_Missense_Mutation_p.S468C	NM_001251962.1	NP_001238891.1	Q96DR7	ARHGQ_HUMAN	Rho guanine nucleotide exchange factor (GEF) 26	468	DH.				regulation of Rho protein signal transduction	intracellular|ruffle	Rho guanyl-nucleotide exchange factor activity			endometrium(4)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|pancreas(1)|urinary_tract(1)	23						TTTAAAAATTCTAAAGAACTG	0.363000													5	8					0	0	1	0	0
NELFA	7469	broad.mit.edu	37	4	1991499	1991499	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr4:1991499C>T	ENST00000382882.3	-	3	1630	c.513G>A	c.(511-513)gtG>gtA	p.V171V	NELFA_ENST00000411638.2_Silent_p.V160V|NELFA_ENST00000542778.1_Silent_p.V25V					negative elongation factor complex member A																		GAAAATGCTTCACCGGGGGAG	0.612000													50	94					0	0	1	0	0
CHST6	4166	broad.mit.edu	37	16	75513367	75513367	+	Silent	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr16:75513367G>C	ENST00000332272.4	-	3	539	c.360C>G	c.(358-360)ctC>ctG	p.L120L	CHST6_ENST00000390664.2_Silent_p.L120L|RP11-77K12.4_ENST00000530512.3_RNA	NM_021615.4	NP_067628.1	Q9GZX3	CHST6_HUMAN	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6	120					keratan sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	N-acetylglucosamine 6-O-sulfotransferase activity			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						CCCACTGGAAGAGGTCGGACA	0.662000													23	31					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152477104	152477104	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:152477104C>T	ENST00000367255.5	-	132	24520	c.23919G>A	c.(23917-23919)acG>acA	p.T7973T	SYNE1_ENST00000354674.4_Silent_p.T128T|SYNE1_ENST00000356820.4_Silent_p.T2497T|SYNE1_ENST00000539504.1_Silent_p.T128T|SYNE1_ENST00000265368.4_Silent_p.T7973T|SYNE1_ENST00000423061.1_Silent_p.T7902T|SYNE1_ENST00000448038.1_Silent_p.T7902T|SYNE1_ENST00000347037.5_5'UTR|SYNE1_ENST00000341594.5_Silent_p.T7585T	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	7973					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CCAGGTTTCTCGTAGCCTGCT	0.532000										HNSCC(10;0.0054)			14	57					0	0	1	0	0
ADCY10	55811	broad.mit.edu	37	1	167798547	167798547	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:167798547C>T	ENST00000367848.1	-	26	3929	c.3432G>A	c.(3430-3432)atG>atA	p.M1144I	ADCY10_ENST00000545172.1_Missense_Mutation_p.M1083I|ADCY10_ENST00000367851.4_Missense_Mutation_p.M1236I			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	1236					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						TCATTTGCATCATAACTGCCA	0.413000													26	89					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	rs104886003		TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:178936091G>A	ENST00000263967.3	+	10	1790	c.1633G>A	c.(1633-1635)Gag>Aag	p.E545K		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	545	PI3K helical.		E -> A (in cancer).|E -> G (in KERSEB).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(881)|p.E545Q(18)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353000	E545K(BC3C_URINARY_TRACT)|E545K(BFTC909_KIDNEY)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(HCC202_BREAST)|E545K(HCT15_LARGE_INTESTINE)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(KYSE510_OESOPHAGUS)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(MCF7_BREAST)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(NCIH460_LUNG)|E545K(NCIH508_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(RERFLCSQ1_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			6	50					0	0	1	0	0
OR6C65	403282	broad.mit.edu	37	12	55794872	55794872	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:55794872G>C	ENST00000379665.2	+	1	659	c.560G>C	c.(559-561)tGc>tCc	p.C187S		NM_001005518.1	NP_001005518.1	A6NJZ3	O6C65_HUMAN	olfactory receptor, family 6, subfamily C, member 65	187					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(3)|lung(9)	15						CTGATTGCTTGCACAGACACA	0.448000													74	105					0	0	1	0	0
PSG3	5671	broad.mit.edu	37	19	43236942	43236942	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:43236942G>C	ENST00000327495.5	-	3	887	c.703C>G	c.(703-705)Ctc>Gtc	p.L235V	PSG3_ENST00000595140.1_Missense_Mutation_p.L235V	NM_021016.3	NP_066296.2	Q16557	PSG3_HUMAN	pregnancy specific beta-1-glycoprotein 3	235					defense response|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	36		Prostate(69;0.00682)				TCACGGAGGAGATTCAGGGTG	0.537000													98	270					0	0	1	0	0
ANKRD6	22881	broad.mit.edu	37	6	90333717	90333717	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:90333717G>C	ENST00000369408.5	+	11	1403	c.1054G>C	c.(1054-1056)Gag>Cag	p.E352Q	ANKRD6_ENST00000447838.2_Missense_Mutation_p.E387Q|ANKRD6_ENST00000339746.4_Missense_Mutation_p.E387Q|ANKRD6_ENST00000520793.1_Missense_Mutation_p.E328Q|LYRM2_ENST00000520441.1_Intron|ANKRD6_ENST00000522441.1_Missense_Mutation_p.E387Q	NM_001242813.1	NP_001229742.1	Q9Y2G4	ANKR6_HUMAN	ankyrin repeat domain 6	387							protein binding			NS(1)|endometrium(3)|large_intestine(7)|lung(3)|ovary(3)|pancreas(1)|prostate(1)|stomach(2)	21		all_cancers(76;1.22e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;1.83e-05)|Lung NSC(302;0.239)		BRCA - Breast invasive adenocarcinoma(108;0.0209)		CCCACCCCATGAGTTCAGGGC	0.537000													6	17					0	0	1	0	0
NF2	4771	broad.mit.edu	37	22	30057257	30057257	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr22:30057257G>T	ENST00000338641.4	+	8	1180	c.739G>T	c.(739-741)Gag>Tag	p.E247*	NF2_ENST00000334961.7_Nonsense_Mutation_p.E164*|NF2_ENST00000397789.3_Nonsense_Mutation_p.E247*|NF2_ENST00000403435.1_Nonsense_Mutation_p.E247*|NF2_ENST00000361452.4_Nonsense_Mutation_p.E206*|NF2_ENST00000413209.2_Intron|NF2_ENST00000361166.4_Nonsense_Mutation_p.E247*|NF2_ENST00000353887.4_Nonsense_Mutation_p.E164*|NF2_ENST00000347330.5_Nonsense_Mutation_p.E88*|NF2_ENST00000403999.3_Nonsense_Mutation_p.E247*|NF2_ENST00000361676.4_Nonsense_Mutation_p.E205*	NM_000268.3|NM_016418.5|NM_181832.2	NP_000259.1|NP_057502.2|NP_861970.1	P35240	MERL_HUMAN	neurofibromin 2 (merlin)	247	FERM.				actin cytoskeleton organization|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of cell-matrix adhesion|negative regulation of DNA replication|negative regulation of tyrosine phosphorylation of Stat3 protein|negative regulation of tyrosine phosphorylation of Stat5 protein|positive regulation of stress fiber assembly|regulation of hippo signaling cascade|Schwann cell proliferation	cytoskeleton|early endosome|extrinsic to membrane|filopodium membrane|nucleolus|perinuclear region of cytoplasm|ruffle membrane	cytoskeletal protein binding|protein binding	p.?(3)|p.L232_P257del(1)|p.E247fs*4(1)|p.N226_E270del(1)|p.D245fs*31(1)|p.E247K(1)		NS(1)|bone(2)|breast(5)|central_nervous_system(21)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(17)|large_intestine(9)|liver(1)|lung(9)|meninges(372)|ovary(2)|pituitary(1)|pleura(9)|prostate(1)|skin(7)|soft_tissue(303)|stomach(2)|thyroid(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	776						TTATGACCCTGAGAACAGACT	0.502000			"""D, Mis, N, F, S, O"""		"""meningioma, acoustic neuroma, renal """	"""meningioma, acoustic neuroma"""			Neurofibromatosis, type 2				42	45					4.00102e-26	4.23733e-26	1	1	0
RFX6	222546	broad.mit.edu	37	6	117252568	117252568	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:117252568C>G	ENST00000332958.2	+	19	2702	c.2686C>G	c.(2686-2688)Caa>Gaa	p.Q896E		NM_173560.3	NP_775831.2	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	896					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(29)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	59						GTATCCAGCTCAAGAAACCCT	0.448000													26	66					0	0	1	0	0
IPO13	9670	broad.mit.edu	37	1	44424184	44424184	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:44424184C>T	ENST00000372343.3	+	10	2463	c.1801C>T	c.(1801-1803)Ctt>Ttt	p.L601F		NM_014652.3	NP_055467.3	O94829	IPO13_HUMAN	importin 13	601					protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(6)|lung(13)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				GCTGTCAGCTCTTCAAGTGGA	0.552000													9	96					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8633395	8633395	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:8633395C>G	ENST00000381196.4	-	11	817	c.274G>C	c.(274-276)Gat>Cat	p.D92H	PTPRD_ENST00000358503.5_Missense_Mutation_p.D92H|PTPRD_ENST00000463477.1_Missense_Mutation_p.D92H|PTPRD_ENST00000540109.1_Missense_Mutation_p.D92H|PTPRD_ENST00000537002.1_Missense_Mutation_p.D92H|PTPRD_ENST00000355233.5_Missense_Mutation_p.D92H|PTPRD_ENST00000397611.3_Missense_Mutation_p.D92H|PTPRD_ENST00000360074.4_Missense_Mutation_p.D92H|PTPRD_ENST00000486161.1_Missense_Mutation_p.D92H|PTPRD_ENST00000397606.3_Missense_Mutation_p.D92H|PTPRD_ENST00000397617.3_Missense_Mutation_p.D92H|PTPRD_ENST00000356435.5_Missense_Mutation_p.D92H	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	92	Ig-like C2-type 1.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		ATGGCCTCATCCCTCGGAGTC	0.443000										TSP Lung(15;0.13)			28	72					0	0	1	0	0
TTC17	55761	broad.mit.edu	37	11	43380573	43380573	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:43380573C>T	ENST00000039989.4	+	1	83	c.69C>T	c.(67-69)ctC>ctT	p.L23L	TTC17_ENST00000299240.6_Silent_p.L23L|RP11-484D2.2_ENST00000526220.1_RNA	NM_018259.5	NP_060729.2	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17	23							binding			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(27)|ovary(5)|prostate(3)|skin(3)	53						GCTGGCTCCTCAGCCTTTCCG	0.711000													4	7					0	0	1	0	0
ADRBK1	156	broad.mit.edu	37	11	67052909	67052909	+	Silent	SNP	C	C	T	rs144172325		TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:67052909C>T	ENST00000308595.5	+	21	2348	c.2058C>T	c.(2056-2058)gcC>gcT	p.A686A	ADRBK1_ENST00000526285.1_Intron	NM_001619.3	NP_001610.2	P25098	ARBK1_HUMAN	adrenergic, beta, receptor kinase 1	686					activation of phospholipase C activity|cardiac muscle contraction|desensitization of G-protein coupled receptor protein signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of striated muscle contraction|negative regulation of the force of heart contraction by chemical signal|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of catecholamine secretion|tachykinin receptor signaling pathway	cytosol|soluble fraction	alpha-2A adrenergic receptor binding|ATP binding|beta-adrenergic receptor kinase activity|Edg-2 lysophosphatidic acid receptor binding|G-protein coupled receptor kinase activity|signal transducer activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|liver(2)|lung(8)|prostate(2)	22			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)		Adenosine triphosphate(DB00171)	GCGGCAGTGCCAACGGCCTCT	0.542000													7	16					0	0	1	0	0
PLCXD3	345557	broad.mit.edu	37	5	41382631	41382631	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:41382631G>A	ENST00000377801.3	-	2	183	c.109C>T	c.(109-111)Cat>Tat	p.H37Y	PLCXD3_ENST00000328457.3_Missense_Mutation_p.H37Y			Q63HM9	PLCX3_HUMAN	phosphatidylinositol-specific phospholipase C, X domain containing 3	37	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37						AAGGAATCATGAGACCCTAGG	0.458000													36	47					0	0	1	0	0
RPS4Y2	140032	broad.mit.edu	37	Y	22918664	22918664	+	Splice_Site	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrY:22918664G>A	ENST00000288666.5	+	2	4	c.4G>A	c.(4-6)Gcc>Acc	p.A2T		NM_001039567.2	NP_001034656.1	Q8TD47	RS4Y2_HUMAN	ribosomal protein S4, Y-linked 2	2					translation	ribosome	rRNA binding|structural constituent of ribosome			lung(2)	2						TCTTTTTCAGGCCCGGGGCCC	0.433000													6	10					0	0	1	0	0
EED	8726	broad.mit.edu	37	11	85977176	85977176	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:85977176C>T	ENST00000263360.6	+	8	1464	c.778C>T	c.(778-780)Ctt>Ttt	p.L260F	EED_ENST00000528180.1_Intron|EED_ENST00000327320.4_Missense_Mutation_p.L260F|EED_ENST00000351625.6_Missense_Mutation_p.L260F	NM_003797.3	NP_003788.2	O75530	EED_HUMAN	embryonic ectoderm development	260	Interaction with EZH2 (By similarity).|Required for interaction with the matrix protein MA of HIV-1.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|identical protein binding			haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(2)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	21		Acute lymphoblastic leukemia(157;7.24e-07)|all_hematologic(158;0.00092)				GGATCATTCTCTTAAACTTTG	0.289000													53	101					0	0	1	0	0
KIF18A	81930	broad.mit.edu	37	11	28104452	28104452	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:28104452C>T	ENST00000263181.6	-	9	1503	c.1213G>A	c.(1213-1215)Gac>Aac	p.D405N		NM_031217.3	NP_112494.3	Q8NI77	KI18A_HUMAN	kinesin family member 18A	405					blood coagulation|microtubule depolymerization|microtubule-based movement|mitotic metaphase plate congression|mitotic prometaphase|protein transport	caveola|cytosol|kinetochore microtubule|microtubule organizing center|nucleus|ruffle	actin binding|ATP binding|microtubule plus-end binding|plus-end-directed microtubule motor activity|tubulin-dependent ATPase activity|ubiquitin binding			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(10)|ovary(3)|prostate(1)|skin(1)|urinary_tract(2)	36						TTTGCTTGGTCATTTTCATTA	0.264000													4	34					0	0	1	0	0
RAPGEF5	9771	broad.mit.edu	37	7	22233637	22233637	+	Silent	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr7:22233637C>G	ENST00000344041.6	-	10	864	c.552G>C	c.(550-552)gtG>gtC	p.V184V	RAPGEF5_ENST00000405243.1_Silent_p.V337V|RAPGEF5_ENST00000475788.1_5'UTR	NM_012294.3	NP_036426.3	Q92565	RPGF5_HUMAN	Rap guanine nucleotide exchange factor (GEF) 5	0	N-terminal Ras-GEF.				nervous system development|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	nucleus	GTP-dependent protein binding|Rap guanyl-nucleotide exchange factor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(2)|ovary(1)	6						GAACAGTCGTCACTTCATCAT	0.493000													45	142					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166901813	166901813	+	Missense_Mutation	SNP	C	C	G	rs138602926		TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:166901813C>G	ENST00000423058.2	-	10	1419	c.1402G>C	c.(1402-1404)Gaa>Caa	p.E468Q	AC010127.3_ENST00000599041.1_RNA|SCN1A_ENST00000303395.4_Missense_Mutation_p.E468Q|AC010127.3_ENST00000595647.1_RNA|AC010127.3_ENST00000595268.1_RNA|SCN1A_ENST00000409050.1_Missense_Mutation_p.E468Q|SCN1A_ENST00000375405.3_Missense_Mutation_p.E468Q	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	468						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CTGGAATGTTCTGAGGCAGTT	0.458000													8	115					0	0	1	0	0
EXTL2	2135	broad.mit.edu	37	1	101343047	101343047	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:101343047C>T	ENST00000370114.3	-	3	1854	c.418G>A	c.(418-420)Gaa>Aaa	p.E140K	EXTL2_ENST00000370113.3_Missense_Mutation_p.E140K|EXTL2_ENST00000535414.1_Missense_Mutation_p.E127K	NM_001033025.2|NM_001261440.1	NP_001028197.1|NP_001248369.1	Q9UBQ6	EXTL2_HUMAN	exostosin-like glycosyltransferase 2	140					N-acetylglucosamine metabolic process|UDP-N-acetylgalactosamine metabolic process	extracellular region|integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,4-N-acetylgalactosaminyltransferase activity|glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(4)|skin(1)|urinary_tract(1)	14		all_epithelial(167;2.48e-06)|all_lung(203;0.000414)|Lung NSC(277;0.000946)		Epithelial(280;0.0425)|all cancers(265;0.0628)|COAD - Colon adenocarcinoma(174;0.148)|Colorectal(144;0.167)|Lung(183;0.195)		GTTTCCAGTTCAGGAAAGACC	0.488000													13	48					0	0	1	0	0
ZBTB49	166793	broad.mit.edu	37	4	4322918	4322918	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr4:4322918G>A	ENST00000337872.4	+	8	2294	c.2173G>A	c.(2173-2175)Gac>Aac	p.D725N	ZBTB49_ENST00000538529.1_Missense_Mutation_p.D208N|ZBTB49_ENST00000355834.3_Missense_Mutation_p.D603N	NM_145291.3	NP_660334.3	Q6ZSB9	ZBT49_HUMAN	zinc finger and BTB domain containing 49	725					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	28						CCACGGCGGTGACCCCCTGGG	0.587000													12	15					0	0	1	0	0
WHSC1	7468	broad.mit.edu	37	4	1977056	1977056	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr4:1977056C>T	ENST00000382895.3	+	22	3981	c.3550C>T	c.(3550-3552)Ctg>Ttg	p.L1184L	WHSC1_ENST00000508803.1_Silent_p.L1184L|WHSC1_ENST00000382892.2_Silent_p.L1184L|WHSC1_ENST00000382891.5_Silent_p.L1184L|WHSC1_ENST00000482415.2_3'UTR|WHSC1_ENST00000382888.3_Silent_p.L532L	NM_133330.2	NP_579877.1	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1	1184	SET.				anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	48		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		CCTCGATTGTCTGGGCAATGA	0.532000			T	IGH@	MM								18	24					0	0	1	0	0
ZNF75D	7626	broad.mit.edu	37	X	134425016	134425016	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrX:134425016C>G	ENST00000370766.3	-	6	3451	c.742G>C	c.(742-744)Gag>Cag	p.E248Q	ZNF75D_ENST00000370764.1_Missense_Mutation_p.E153Q|ZNF75D_ENST00000494295.1_Intron	NM_007131.3	NP_009062.2	P51815	ZN75D_HUMAN	zinc finger protein 75D	248	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(14)|upper_aerodigestive_tract(1)|urinary_tract(2)	31						AATTGCCACTCTTCCTCAGAA	0.393000													8	85					0	0	1	0	0
PARP8	79668	broad.mit.edu	37	5	50091139	50091139	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:50091139C>T	ENST00000281631.5	+	12	1474	c.1316C>T	c.(1315-1317)tCa>tTa	p.S439L	PARP8_ENST00000514067.2_Missense_Mutation_p.S439L|PARP8_ENST00000503750.2_Missense_Mutation_p.S439L|PARP8_ENST00000511363.2_3'UTR|PARP8_ENST00000505697.2_Missense_Mutation_p.S439L|PARP8_ENST00000505554.1_Missense_Mutation_p.S418L|PARP8_ENST00000514342.2_Missense_Mutation_p.S192L	NM_001178056.1|NM_024615.3	NP_001171527.1|NP_078891.2	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	439						intracellular	NAD+ ADP-ribosyltransferase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(23)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Lung NSC(810;0.0305)|Breast(144;0.222)				GCCCCCAAGTCATCCAAAACT	0.438000													22	50					0	0	1	0	0
COLGALT2	23127	broad.mit.edu	37	1	183920242	183920242	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:183920242G>A	ENST00000361927.4	-	8	1406	c.1035C>T	c.(1033-1035)ttC>ttT	p.F345F	COLGALT2_ENST00000367520.3_Silent_p.F82F|COLGALT2_ENST00000546159.1_Silent_p.F345F	NM_015101.2	NP_055916.1			collagen beta(1-O)galactosyltransferase 2																		GGTTTATCATGAAAATCTAAT	0.403000													72	109					0	0	1	0	0
SCUBE1	80274	broad.mit.edu	37	22	43627846	43627846	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr22:43627846C>T	ENST00000360835.4	-	8	1006	c.880G>A	c.(880-882)Gac>Aac	p.D294N		NM_173050.3	NP_766638.2	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1		EGF-like 7; calcium-binding (Potential).				adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(4)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		all_neural(38;0.0414)|Ovarian(80;0.07)				CAGAAGTGGTCGCAGCCTCCG	0.647000											OREG0026615	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	16					0	0	1	0	0
NKTR	4820	broad.mit.edu	37	3	42680599	42680599	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:42680599G>C	ENST00000232978.8	+	13	3591	c.3403G>C	c.(3403-3405)Gat>Cat	p.D1135H	RP4-613B23.1_ENST00000438017.1_RNA|RP4-613B23.1_ENST00000434363.1_RNA|RP4-613B23.1_ENST00000445452.1_RNA	NM_005385.3	NP_005376.2	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	1135					protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	41				KIRC - Kidney renal clear cell carcinoma(284;0.24)		CTGCACTCCTGATAGGAGTTC	0.448000													26	55					0	0	1	0	0
KIAA0368	23392	broad.mit.edu	37	9	114134882	114134882	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:114134882G>C	ENST00000259335.4	-	43	4888	c.4889C>G	c.(4888-4890)tCt>tGt	p.S1630C	KIAA0368_ENST00000338205.5_Missense_Mutation_p.S1452C|KIAA0368_ENST00000374378.3_5'UTR	NM_001080398.1	NP_001073867.1			KIAA0368											NS(2)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(23)|prostate(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	65						CAAAGCACAAGAGGTCTTGTA	0.363000													5	24					0	0	1	0	0
OGFOD3	79701	broad.mit.edu	37	17	80373478	80373478	+	Missense_Mutation	SNP	C	C	T	rs116051835	by1000genomes	TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:80373478C>T	ENST00000313056.5	-	2	251	c.100G>A	c.(100-102)Gag>Aag	p.E34K	OGFOD3_ENST00000329197.5_Missense_Mutation_p.E34K	NM_024648.2|NM_175902.4	NP_078924.1|NP_787098.3			2-oxoglutarate and iron-dependent oxygenase domain containing 3																		CTCTGCACCTCCCGCGGGGCT	0.637000													14	23					0	0	1	0	0
ARL6IP6	151188	broad.mit.edu	37	2	153591519	153591519	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:153591519C>G	ENST00000326446.5	+	3	1177	c.466C>G	c.(466-468)Cta>Gta	p.L156V	ARL6IP6_ENST00000463690.1_3'UTR	NM_152522.5	NP_689735.1	Q8N6S5	AR6P6_HUMAN	ADP-ribosylation-like factor 6 interacting protein 6	156						integral to membrane				kidney(1)|large_intestine(1)|lung(2)|pancreas(1)	5						ATTCTGGACTCTACTTATAAT	0.363000													25	87					0	0	1	0	0
PCDHB8	56128	broad.mit.edu	37	5	140558545	140558545	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:140558545C>T	ENST00000239444.2	+	1	1175	c.930C>T	c.(928-930)ttC>ttT	p.F310F		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		310	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AACTTGATTTCGAAAAATTTC	0.383000													32	275					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34064217	34064217	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:34064217G>A	ENST00000389232.4	+	63	8983	c.8913G>A	c.(8911-8913)ctG>ctA	p.L2971L	RYR3_ENST00000415757.3_Silent_p.L2971L	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	2971					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CAGAAAACCTGAAACTTGGGA	0.473000													5	16					0	0	1	0	0
ZNF441	126068	broad.mit.edu	37	19	11890924	11890924	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:11890924G>A	ENST00000357901.4	+	4	387	c.285G>A	c.(283-285)gaG>gaA	p.E95E	ZNF441_ENST00000454339.2_Silent_p.E28E	NM_152355.2	NP_689568.2	Q8N8Z8	ZN441_HUMAN	zinc finger protein 441	95					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						TTGTGAACGAGAAAATACCTG	0.413000													21	53					0	0	1	0	0
ABI2	10152	broad.mit.edu	37	2	204244965	204244965	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:204244965G>A	ENST00000295851.5	+	3	616	c.320G>A	c.(319-321)aGa>aAa	p.R107K	ABI2_ENST00000422511.2_Missense_Mutation_p.R107K|ABI2_ENST00000261016.6_Missense_Mutation_p.R62K|ABI2_ENST00000424558.1_Missense_Mutation_p.R107K|ABI2_ENST00000261017.5_Missense_Mutation_p.R107K|ABI2_ENST00000430418.1_Missense_Mutation_p.R107K	NM_001282925.1|NM_001282926.1	NP_001269854.1|NP_001269855.1	Q9NYB9	ABI2_HUMAN	abl-interactor 2		t-SNARE coiled-coil homology.				actin polymerization or depolymerization|cell migration|peptidyl-tyrosine phosphorylation	cytoskeleton|cytosol|filopodium|lamellipodium	cytoskeletal adaptor activity|DNA binding|kinase binding|proline-rich region binding|SH3 domain binding|ubiquitin protein ligase binding			breast(1)|kidney(3)|large_intestine(1)|liver(2)|lung(4)|prostate(2)|skin(1)|urinary_tract(1)	15						GTTGCAAGAAGAGAAATTGGT	0.299000													17	48					0	0	1	0	0
DENND4A	10260	broad.mit.edu	37	15	65983618	65983618	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:65983618C>T	ENST00000443035.3	-	23	3526	c.3311G>A	c.(3310-3312)gGa>gAa	p.G1104E	DENND4A_ENST00000431932.2_Missense_Mutation_p.G1061E	NM_001144823.1	NP_001138295.1	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A	1061					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(11)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	51						TGCATCAGCTCCCAATTTTTC	0.378000													5	31					0	0	1	0	0
XAF1	54739	broad.mit.edu	37	17	6663026	6663026	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:6663026G>C	ENST00000361842.3	+	3	453	c.214G>C	c.(214-216)Gag>Cag	p.E72Q	XAF1_ENST00000441631.1_Intron|XAF1_ENST00000346752.4_Intron|XAF1_ENST00000438512.1_Missense_Mutation_p.E72Q	NM_017523.3	NP_059993.2	Q6GPH4	XAF1_HUMAN	XIAP associated factor 1	72					apoptosis|type I interferon-mediated signaling pathway	mitochondrion|nucleus	zinc ion binding			large_intestine(2)|lung(2)|prostate(1)|urinary_tract(1)	6						GTCCTCGCTGGAGTTTCATAA	0.507000													12	48					0	0	1	0	0
SOGA2	23255	broad.mit.edu	37	18	8825631	8825631	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr18:8825631G>A	ENST00000359865.3	+	15	4265	c.4123G>A	c.(4123-4125)Gag>Aag	p.E1375K	SOGA2_ENST00000306285.7_Missense_Mutation_p.E700K|SOGA2_ENST00000518815.1_Missense_Mutation_p.E700K|SOGA2_ENST00000517570.1_Missense_Mutation_p.E1334K|SOGA2_ENST00000400050.3_Missense_Mutation_p.E1334K|SOGA2_ENST00000306329.11_Missense_Mutation_p.E1694K	NM_015210.3	NP_056025.2	Q9Y4B5	CC165_HUMAN	SOGA family member 2	1685																	CCCTGCCATCGAGAAGGTGCA	0.607000													10	22					0	0	1	0	0
GPC5	2262	broad.mit.edu	37	13	92345940	92345940	+	Silent	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr13:92345940C>G	ENST00000377067.3	+	3	1197	c.825C>G	c.(823-825)ctC>ctG	p.L275L		NM_004466.4	NP_004457.1	P78333	GPC5_HUMAN	glypican 5	275						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(4)|endometrium(6)|kidney(4)|large_intestine(7)|lung(34)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				GATACTGCCTCAATGTCATGC	0.547000													5	73					0	0	1	0	0
KRT8	3856	broad.mit.edu	37	12	53292539	53292539	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:53292539C>A	ENST00000552551.1	-	7	1558	c.1126G>T	c.(1126-1128)Gag>Tag	p.E376*	KRT8_ENST00000552150.1_Nonsense_Mutation_p.E404*|KRT8_ENST00000546897.1_Nonsense_Mutation_p.E376*|KRT8_ENST00000293308.6_Nonsense_Mutation_p.E376*			P05787	K2C8_HUMAN	keratin 8	376	Coil 2.|Necessary for interaction with PNN.|Rod.				cytoskeleton organization|interspecies interaction between organisms	cytoplasm|keratin filament|nuclear matrix|nucleoplasm	protein binding|structural molecule activity			endometrium(5)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|prostate(1)|skin(1)	13				BRCA - Breast invasive adenocarcinoma(357;0.108)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTCATCAGCTCCTGGTACTCA	0.642000													40	51					7.63091e-17	8.00015e-17	1	1	0
ATF6B	1388	broad.mit.edu	37	6	32085730	32085730	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:32085730C>T	ENST00000375201.4	-	12	1366	c.1321G>A	c.(1321-1323)Gag>Aag	p.E441K	ATF6B_ENST00000375203.3_Missense_Mutation_p.E444K			Q99941	ATF6B_HUMAN	activating transcription factor 6 beta	444		Cleavage; by PS1 (By similarity).			response to unfolded protein|signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|prostate(2)|skin(1)|urinary_tract(1)	22						GGCTCTTGCTCTGAGAACCCC	0.602000													13	19					0	0	1	0	0
CCDC148	130940	broad.mit.edu	37	2	159195330	159195330	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:159195330C>G	ENST00000283233.5	-	7	985	c.672G>C	c.(670-672)ttG>ttC	p.L224F	CCDC148_ENST00000409187.1_Missense_Mutation_p.L233F|CCDC148_ENST00000409889.1_Missense_Mutation_p.L224F|CCDC148_ENST00000536771.1_Missense_Mutation_p.L138F	NM_138803.3	NP_620158.3	Q8NFR7	CC148_HUMAN	coiled-coil domain containing 148	224										endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23						TTGAAGATTTCAAATCAGGGT	0.353000													18	52					0	0	1	0	0
ANKAR	150709	broad.mit.edu	37	2	190541406	190541406	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:190541406C>G	ENST00000520309.1	+	2	278	c.190C>G	c.(190-192)Caa>Gaa	p.Q64E	ANKAR_ENST00000313581.4_Missense_Mutation_p.Q64E|ANKAR_ENST00000461516.1_Intron|ANKAR_ENST00000438402.2_Missense_Mutation_p.Q64E|ANKAR_ENST00000281412.6_5'UTR|ANKAR_ENST00000431575.2_5'UTR	NM_144708.3	NP_653309.3	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	64						integral to membrane	binding			breast(3)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(16)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(2)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			TGTGCGCTCTCAAGTAGACCT	0.438000													26	87					0	0	1	0	0
SATB2	23314	broad.mit.edu	37	2	200137286	200137286	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:200137286G>A	ENST00000443023.1	-	10	3138	c.1673C>T	c.(1672-1674)tCt>tTt	p.S558F	SATB2_ENST00000457245.1_Missense_Mutation_p.S617F|SATB2_ENST00000428695.1_Missense_Mutation_p.S499F|SATB2_ENST00000417098.1_Missense_Mutation_p.S617F|SATB2_ENST00000260926.5_Missense_Mutation_p.S617F			Q9UPW6	SATB2_HUMAN	SATB homeobox 2	617						cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(40)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						CTTTGTGCGAGACCGGGGCTT	0.557000													24	66					0	0	1	0	0
HADHA	3030	broad.mit.edu	37	2	26424095	26424095	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:26424095C>G	ENST00000380649.3	-	13	1444	c.1315G>C	c.(1315-1317)Gaa>Caa	p.E439Q		NM_000182.4	NP_000173.2	P40939	ECHA_HUMAN	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit	439					fatty acid beta-oxidation	fatty acid beta-oxidation multienzyme complex|mitochondrial nucleoid|nucleolus	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acetyltransferase activity|coenzyme binding|enoyl-CoA hydratase activity|long-chain-3-hydroxyacyl-CoA dehydrogenase activity|protein binding			autonomic_ganglia(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(4)|skin(1)	30	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				NADH(DB00157)	TCGGCCTTTTCAAAACCTTGG	0.423000													16	39					0	0	1	0	0
ZBTB4	57659	broad.mit.edu	37	17	7369149	7369149	+	Silent	SNP	C	C	G	rs143028324		TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:7369149C>G	ENST00000311403.4	-	3	1311	c.972G>C	c.(970-972)ctG>ctC	p.L324L	ZBTB4_ENST00000380599.4_Silent_p.L324L	NM_020899.3	NP_065950.2	Q9P1Z0	ZBTB4_HUMAN	zinc finger and BTB domain containing 4	324					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(7)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|prostate(3)|skin(6)	36		Colorectal(1115;3.46e-05)|Myeloproliferative disorder(207;0.0255)		COAD - Colon adenocarcinoma(228;4.1e-06)|READ - Rectum adenocarcinoma(115;0.0642)		TGTGTCTCTTCAGACTGGACA	0.607000													18	33					0	0	1	0	0
TGS1	96764	broad.mit.edu	37	8	56695312	56695312	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr8:56695312G>A	ENST00000260129.5	+	2	584	c.107G>A	c.(106-108)cGa>cAa	p.R36Q		NM_024831.6	NP_079107.6	Q96RS0	TGS1_HUMAN	trimethylguanosine synthase 1	36					cellular lipid metabolic process|ncRNA metabolic process|regulation of transcription, DNA-dependent|RNA capping|spliceosomal snRNP assembly|transcription, DNA-dependent	Cajal body|cytosol	RNA trimethylguanosine synthase activity			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29		all_lung(136;0.119)|all_epithelial(80;0.125)|Lung NSC(129;0.147)	Epithelial(17;0.00027)|all cancers(17;0.00251)			CGCAGGGATCGAAAATTGTAC	0.313000													21	55					0	0	1	0	0
NUP43	348995	broad.mit.edu	37	6	150059906	150059906	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:150059906C>G	ENST00000340413.2	-	5	587	c.511G>C	c.(511-513)Gat>Cat	p.D171H	NUP43_ENST00000367404.4_Intron|NUP43_ENST00000460354.2_Missense_Mutation_p.D171H|NUP43_ENST00000367403.3_Intron	NM_198887.1	NP_942590.1	Q8NFH3	NUP43_HUMAN	nucleoporin 43kDa	171					carbohydrate metabolic process|cell division|chromosome segregation|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	protein binding			breast(1)|large_intestine(2)|lung(8)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	18		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;4.71e-13)|GBM - Glioblastoma multiforme(68;0.101)		GTACTACTATCTGCATTGTCT	0.333000													25	85					0	0	1	0	0
LRRC37A3	374819	broad.mit.edu	37	17	62865241	62865241	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:62865241G>C	ENST00000584306.1	-	8	3480	c.2950C>G	c.(2950-2952)Ctc>Gtc	p.L984V	LRRC37A3_ENST00000339474.5_Missense_Mutation_p.L102V|LRRC37A3_ENST00000319651.5_Missense_Mutation_p.L984V|LRRC37A3_ENST00000400877.3_Missense_Mutation_p.L22V	NM_199340.2	NP_955372.2	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	984						integral to membrane				NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|liver(1)|lung(10)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						AATTTAAAGAGATATGGATCT	0.299000													40	126					0	0	1	0	0
PDZD8	118987	broad.mit.edu	37	10	119134253	119134253	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:119134253G>A	ENST00000334464.5	-	1	725	c.486C>T	c.(484-486)ctC>ctT	p.L162L		NM_173791.3	NP_776152.1	Q8NEN9	PDZD8_HUMAN	PDZ domain containing 8	162					intracellular signal transduction		metal ion binding			kidney(3)|large_intestine(8)|lung(24)|upper_aerodigestive_tract(3)	38		Colorectal(252;0.19)		all cancers(201;0.0121)		CTGGCCGCACGAGCCGGATGG	0.731000													4	17					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8485769	8485769	+	Silent	SNP	C	C	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:8485769C>A	ENST00000381196.4	-	25	3591	c.3048G>T	c.(3046-3048)gtG>gtT	p.V1016V	PTPRD_ENST00000358503.5_Silent_p.V994V|PTPRD_ENST00000540109.1_Silent_p.V1016V|PTPRD_ENST00000537002.1_Intron|PTPRD_ENST00000355233.5_Intron|PTPRD_ENST00000397611.3_Intron|PTPRD_ENST00000471274.1_5'UTR|PTPRD_ENST00000360074.4_Silent_p.V1003V|PTPRD_ENST00000486161.1_Intron|PTPRD_ENST00000397606.3_Intron|PTPRD_ENST00000397617.3_Intron|PTPRD_ENST00000356435.5_Silent_p.V1016V	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1016					transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TACCTTGATCCACAGGCAGTG	0.448000										TSP Lung(15;0.13)			4	9					5.9392e-07	6.10353e-07	1	1	0
HADHB	3032	broad.mit.edu	37	2	26486347	26486347	+	Splice_Site	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:26486347C>T	ENST00000317799.5	+	4	313	c.209C>T	c.(208-210)tCa>tTa	p.S70L	HADHB_ENST00000405867.3_Splice_Site_p.S70L|HADHB_ENST00000494615.1_3'UTR|HADHB_ENST00000537713.1_Splice_Site_p.S70L|HADHB_ENST00000545822.1_Splice_Site_p.S48L	NM_000183.2	NP_000174.1	P55084	ECHB_HUMAN	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit	70					fatty acid beta-oxidation	mitochondrial nucleoid	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acyltransferase activity|enoyl-CoA hydratase activity|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|skin(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCTGGCACTTCGTAAGTATGA	0.378000													16	57					0	0	1	0	0
EDIL3	10085	broad.mit.edu	37	5	83239311	83239311	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:83239311C>T	ENST00000296591.5	-	11	1788	c.1370G>A	c.(1369-1371)aGa>aAa	p.R457K	EDIL3_ENST00000380138.3_Missense_Mutation_p.R447K	NM_005711.3	NP_005702.3	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like domains 3	457	F5/8 type C 2.				cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(5)|skin(3)	31		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)		AGGAAGGATTCTTATGTGTCG	0.468000													11	42					0	0	1	0	0
SPO11	23626	broad.mit.edu	37	20	55909876	55909876	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:55909876G>C	ENST00000371263.3	+	6	690	c.581G>C	c.(580-582)tGt>tCt	p.C194S	SPO11_ENST00000345868.4_Missense_Mutation_p.C156S|SPO11_ENST00000371260.4_Missense_Mutation_p.C156S	NM_012444.2	NP_036576.1	Q9Y5K1	SPO11_HUMAN	SPO11 meiotic protein covalently bound to DSB	194					female gamete generation|reciprocal meiotic recombination	chromosome|nucleus	ATP binding|DNA binding|hydrolase activity			autonomic_ganglia(1)|breast(3)|large_intestine(4)|lung(8)|skin(2)	18	Lung NSC(12;0.0066)|all_lung(29;0.0188)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;1.73e-14)|Epithelial(14;9.02e-10)|all cancers(14;9.31e-09)			AAAGTGAATTGTACCTGTGGT	0.343000								Editing and processing nucleases					10	33					0	0	1	0	0
ZNF451	26036	broad.mit.edu	37	6	57012191	57012191	+	Silent	SNP	T	T	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:57012191T>C	ENST00000370706.4	+	10	1552	c.1308T>C	c.(1306-1308)tcT>tcC	p.S436S	RP11-203B9.4_ENST00000592500.1_RNA|RP11-203B9.4_ENST00000416069.2_RNA|RP11-203B9.4_ENST00000586432.1_RNA|RP11-203B9.4_ENST00000588811.1_RNA|ZNF451_ENST00000491832.2_Silent_p.S436S|RP11-203B9.4_ENST00000592038.1_RNA|ZNF451_ENST00000357489.3_Silent_p.S436S|RP11-203B9.4_ENST00000586668.1_RNA|RP11-203B9.4_ENST00000585792.1_RNA|RP11-203B9.4_ENST00000586053.1_RNA|RP11-203B9.4_ENST00000587815.1_RNA|RP11-203B9.4_ENST00000591553.1_RNA	NM_001031623.2	NP_001026794.1	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451	436					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			TTAAAGAATCTAGCTCACTGG	0.353000													18	56					0	0	1	0	0
KCNT2	343450	broad.mit.edu	37	1	196397285	196397285	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:196397285C>G	ENST00000367433.5	-	10	1035	c.934G>C	c.(934-936)Gat>Cat	p.D312H	KCNT2_ENST00000294725.9_Missense_Mutation_p.D312H|KCNT2_ENST00000498426.1_5'UTR|KCNT2_ENST00000451324.2_Intron|KCNT2_ENST00000367431.4_Missense_Mutation_p.D312H|KCNT2_ENST00000609185.1_Missense_Mutation_p.D312H	NM_198503.2	NP_940905.2	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	312						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						ATAAGTAAATCAATCTTCAGT	0.373000													20	72					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25446503	25446503	+	RNA	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:25446503G>C	ENST00000424208.1	+	0	1988				SNHG14_ENST00000424333.1_RNA|SNORD115-17_ENST00000364612.1_RNA	NR_003305.1																						TTGTCCTGAAGAGAGGTGATG	0.498000													62	219					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141816461	141816461	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:141816461G>C	ENST00000389484.3	-	9	2370	c.1399C>G	c.(1399-1401)Caa>Gaa	p.Q467E		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	467					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CCTGTTGGTTGAGTTCTTTTT	0.358000										TSP Lung(27;0.18)			10	42					0	0	1	0	0
HLA-E	3133	broad.mit.edu	37	6	30458229	30458229	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:30458229G>A	ENST00000376630.4	+	3	612	c.547G>A	c.(547-549)Gac>Aac	p.D183N		NM_005516.5	NP_005507.3	P13747	HLAE_HUMAN	major histocompatibility complex, class I, E	183	Alpha-2.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity			breast(2)|central_nervous_system(4)|endometrium(1)|kidney(3)|large_intestine(2)|lung(1)|ovary(3)|skin(1)|urinary_tract(1)	18						CTACCTGGAAGACACATGCGT	0.597000													20	42					0	0	1	0	0
MRFAP1L1	114932	broad.mit.edu	37	4	6711276	6711276	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr4:6711276G>A	ENST00000320848.6	-	1	331	c.81C>T	c.(79-81)ttC>ttT	p.F27F		NM_203462.2	NP_982287.1	Q96HT8	MR1L1_HUMAN	Morf4 family associated protein 1-like 1	27																	CCGGGAGCAGGAACTGCTCGA	0.632000													21	32					0	0	1	0	0
MSTO1	55154	broad.mit.edu	37	1	155582954	155582954	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:155582954G>A	ENST00000245564.2	+	11	1237	c.1213G>A	c.(1213-1215)Gag>Aag	p.E405K	MSTO1_ENST00000483734.1_3'UTR|MSTO1_ENST00000368341.4_Missense_Mutation_p.E370K|MSTO1_ENST00000538143.1_Intron|MSTO1_ENST00000452804.2_Intron	NM_001256532.1|NM_001256533.1|NM_018116.3	NP_001243461.1|NP_001243462.1|NP_060586.2	Q9BUK6	MSTO1_HUMAN	misato 1, mitochondrial distribution and morphology regulator	405					mitochondrion distribution|protein polymerization	mitochondrial outer membrane|protein complex				breast(2)|endometrium(1)|lung(3)|skin(1)	7	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)					TGCATGTGGGGAGCCTTCTGG	0.567000													19	84					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151860303	151860303	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr7:151860303G>A	ENST00000355193.2	-	43	10577	c.10359C>T	c.(10357-10359)ttC>ttT	p.F3453F	KMT2C_ENST00000262189.6_Silent_p.F3453F					lysine (K)-specific methyltransferase 2C																		CGGAACTGTAGAAGGGAATCT	0.478000													49	149					0	0	1	0	0
ATG2A	23130	broad.mit.edu	37	11	64670063	64670063	+	Silent	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:64670063G>C	ENST00000421419.2	-	27	3816	c.3702C>G	c.(3700-3702)ctC>ctG	p.L1234L	ATG2A_ENST00000377264.3_Silent_p.L1234L			Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1234							protein binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(19)|ovary(3)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	55						TTACGTACTGGAGCAGGTTGA	0.652000													4	10					0	0	1	0	0
EPHA4	2043	broad.mit.edu	37	2	222347094	222347094	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:222347094G>A	ENST00000281821.2	-	5	1337	c.1296C>T	c.(1294-1296)gtC>gtT	p.V432V	EPHA4_ENST00000392071.4_Silent_p.V381V|EPHA4_ENST00000409854.1_Silent_p.V432V|EPHA4_ENST00000409938.1_Silent_p.V432V	NM_004438.3	NP_004429.1	P54764	EPHA4_HUMAN	EPH receptor A4	432	Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(21)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		TGGTCACAGTGACAGAAACTG	0.373000													8	125					0	0	1	0	0
HGS	9146	broad.mit.edu	37	17	79667810	79667810	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:79667810C>T	ENST00000329138.4	+	20	2237	c.2102C>T	c.(2101-2103)tCa>tTa	p.S701L		NM_004712.4	NP_004703.1	O14964	HGS_HUMAN	hepatocyte growth factor-regulated tyrosine kinase substrate	701	Gln-rich.|Interaction with NF2.				cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of JAK-STAT cascade|regulation of protein catabolic process	cytosol|early endosome membrane|multivesicular body membrane	metal ion binding|protein domain specific binding			endometrium(2)|kidney(3)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	12	all_neural(118;0.0878)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)			GGGAGCCAGTCAGTCTCCATG	0.637000													13	35					0	0	1	0	0
A2M	2	broad.mit.edu	37	12	9225252	9225252	+	Silent	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:9225252G>C	ENST00000318602.7	-	30	4279	c.3972C>G	c.(3970-3972)ctC>ctG	p.L1324L		NM_000014.4	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin	1324					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(17)|lung(30)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	77					Bacitracin(DB00626)|Becaplermin(DB00102)	GTCTCACCTGGAGGTAGACAC	0.507000													50	47					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73068104	73068104	+	RNA	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrX:73068104G>A	ENST00000429829.1	-	0	4484					NR_001564.2																						ACTAACAGCAGATAGGGAAAT	0.443000													6	8					0	0	1	0	0
FAM155A	728215	broad.mit.edu	37	13	108518877	108518877	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr13:108518877C>T	ENST00000375915.2	-	1	206	c.68G>A	c.(67-69)cGa>cAa	p.R23Q		NM_001080396.2	NP_001073865.1	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	23						integral to membrane	binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33						CTCGTTCTCTCGGGGTGCTGC	0.532000													55	133					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135428058	135428058	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrX:135428058G>C	ENST00000394143.1	+	6	2484	c.2193G>C	c.(2191-2193)ttG>ttC	p.L731F	GPR112_ENST00000287534.4_Missense_Mutation_p.L668F|GPR112_ENST00000412101.1_Missense_Mutation_p.L526F|GPR112_ENST00000370652.1_Missense_Mutation_p.L731F|GPR112_ENST00000394141.1_Missense_Mutation_p.L526F	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	731					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					TATCCAAATTGACATCACCAT	0.398000													29	17					0	0	1	0	0
ECT2L	345930	broad.mit.edu	37	6	139206926	139206926	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:139206926G>A	ENST00000423192.1	+	17	2379	c.2218G>A	c.(2218-2220)Gca>Aca	p.A740T	ECT2L_ENST00000541398.1_Intron|ECT2L_ENST00000367682.2_Missense_Mutation_p.A740T			Q008S8	ECT2L_HUMAN	epithelial cell transforming sequence 2 oncogene-like	740	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(7)|lung(12)|skin(1)|upper_aerodigestive_tract(1)	30						CTTGACCACTGCAATTGACCA	0.418000			"""N, Splice, Mis"""		ETP ALL								25	53					0	0	1	0	0
UBQLNL	143630	broad.mit.edu	37	11	5537271	5537271	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:5537271C>G	ENST00000380184.1	-	1	664	c.401G>C	c.(400-402)aGa>aCa	p.R134T	HBG2_ENST00000380259.2_Intron	NM_145053.4	NP_659490.4	Q8IYU4	UBQLN_HUMAN	ubiquilin-like	134								p.R134T(1)		endometrium(1)|kidney(3)|large_intestine(9)|lung(13)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	33		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.136)		TTGGTGCACTCTGCTGCTGTT	0.537000													17	55					0	0	1	0	0
KLF1	10661	broad.mit.edu	37	19	12997900	12997900	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:12997900G>A	ENST00000264834.4	-	1	95	c.55C>T	c.(55-57)Ccc>Tcc	p.P19S		NM_006563.3	NP_006554.1	Q13351	KLF1_HUMAN	Kruppel-like factor 1 (erythroid)	19	Pro-rich.				erythrocyte differentiation|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(3)|large_intestine(1)|skin(1)	5		Hepatocellular(1079;0.137)		GBM - Glioblastoma multiforme(1328;0.00016)|Lung(535;0.171)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCGGGAAGGGGCCCAGGGCG	0.657000													23	38					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140996131	140996131	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrX:140996131G>C	ENST00000285879.4	+	4	3227	c.2941G>C	c.(2941-2943)Gac>Cac	p.D981H	MAGEC1_ENST00000406005.2_Missense_Mutation_p.D48H	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	981	MAGE.						protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					AAACACATTAGACCTCACCTC	0.468000										HNSCC(15;0.026)			52	44					0	0	1	0	0
ADAM30	11085	broad.mit.edu	37	1	120438233	120438233	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:120438233C>T	ENST00000369400.1	-	1	885	c.727G>A	c.(727-729)Gat>Aat	p.D243N		NM_021794.3	NP_068566.2	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30	243	Peptidase M12B.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(16)|ovary(2)|skin(2)	38	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		ATACGAACATCTTGAAAGTAG	0.368000													23	70					0	0	1	0	0
SLC46A1	113235	broad.mit.edu	37	17	26731743	26731743	+	Silent	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:26731743G>C	ENST00000440501.1	-	2	1067	c.972C>G	c.(970-972)ctC>ctG	p.L324L	SLC46A1_ENST00000321666.5_Silent_p.L324L|SLC46A1_ENST00000584729.1_5'UTR	NM_080669.4	NP_542400.2	Q96NT5	PCFT_HUMAN	solute carrier family 46 (folate transporter), member 1	324					cellular iron ion homeostasis|folic acid metabolic process	apical plasma membrane|cytoplasm|integral to membrane	folic acid binding|folic acid transporter activity|heme transporter activity			lung(5)	5	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)	Folic Acid(DB00158)	AGTACTGCAGGAGCTTCAGGG	0.577000													13	31					0	0	1	0	0
ZNF257	113835	broad.mit.edu	37	19	22271978	22271978	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:22271978C>G	ENST00000594947.1	+	4	1570	c.1426C>G	c.(1426-1428)Caa>Gaa	p.Q476E		NM_033468.2	NP_258429.2	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	476					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|lung(4)	6		all_lung(12;0.0961)|Lung NSC(12;0.103)				ACACCTTACTCAACATAAAAT	0.383000													16	31					0	0	1	0	0
PSIP1	11168	broad.mit.edu	37	9	15474012	15474012	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:15474012C>T	ENST00000380733.4	-	9	1196	c.853G>A	c.(853-855)Gaa>Aaa	p.E285K	PSIP1_ENST00000397519.2_Missense_Mutation_p.E285K|PSIP1_ENST00000380716.4_Missense_Mutation_p.E285K|PSIP1_ENST00000380715.1_Missense_Mutation_p.E285K|PSIP1_ENST00000380738.4_Missense_Mutation_p.E285K			O75475	PSIP1_HUMAN	PC4 and SFRS1 interacting protein 1	285					initiation of viral infection|interspecies interaction between organisms|nuclear mRNA 5'-splice site recognition|provirus integration|regulation of transcription, DNA-dependent|response to heat|response to oxidative stress|transcription, DNA-dependent	cytosol|nuclear heterochromatin|nuclear periphery|nucleoplasm|transcriptionally active chromatin	activating transcription factor binding|chromatin binding|DNA secondary structure binding|RNA polymerase II transcription coactivator activity			breast(2)|endometrium(2)|kidney(1)|lung(3)|prostate(1)	9				GBM - Glioblastoma multiforme(50;2.38e-06)		TATACCTTTTCACCTTCTTGA	0.274000													8	46					0	0	1	0	0
CD163L1	283316	broad.mit.edu	37	12	7526237	7526237	+	Splice_Site	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:7526237C>T	ENST00000313599.3	-	14	3467		c.e14-1		CD163L1_ENST00000396630.1_Splice_Site|CD163L1_ENST00000416109.2_Splice_Site			Q9NR16	C163B_HUMAN	CD163 molecule-like 1							extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						GCTGTGAATTCTACAGAGAAA	0.438000													7	118					0	0	1	0	0
IGSF11	152404	broad.mit.edu	37	3	118647366	118647366	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:118647366G>A	ENST00000354673.2	-	5	791	c.411C>T	c.(409-411)ctC>ctT	p.L137L	IGSF11_ENST00000491903.1_Silent_p.L138L|IGSF11_ENST00000489689.1_Silent_p.L138L|IGSF11_ENST00000425327.2_Silent_p.L137L|IGSF11_ENST00000393775.2_Silent_p.L138L|IGSF11_ENST00000459718.1_5'UTR|IGSF11_ENST00000441144.2_Silent_p.L137L	NM_152538.2	NP_689751.2	Q5DX21	IGS11_HUMAN	immunoglobulin superfamily, member 11	138					cell adhesion|regulation of growth	integral to membrane|plasma membrane	receptor activity	p.L137L(1)|p.L138L(1)		autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						CTAACACTGTGAGACCGGTGA	0.493000													12	42					0	0	1	0	0
OR10S1	219873	broad.mit.edu	37	11	123847570	123847570	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:123847570G>A	ENST00000531945.1	-	1	918	c.829C>T	c.(829-831)Cgc>Tgc	p.R277C		NM_001004474.1	NP_001004474.1	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S, member 1	277					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	36		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		TCACTGGAGCGAGGCTGCAGG	0.592000													30	72					0	0	1	0	0
MAP4	4134	broad.mit.edu	37	3	47951061	47951061	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:47951061G>A	ENST00000426837.2	-	10	4988	c.4901C>T	c.(4900-4902)tCt>tTt	p.S1634F	MAP4_ENST00000360240.6_Intron|MAP4_ENST00000383737.4_Intron|MAP4_ENST00000395734.3_Intron|MAP4_ENST00000264724.11_Missense_Mutation_p.S224F			P27816	MAP4_HUMAN	microtubule-associated protein 4	991					negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(2)|pancreas(1)|skin(2)	32				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		AACTGCAACAGACCCTTCTTT	0.438000													47	118					0	0	1	0	0
TSPAN33	340348	broad.mit.edu	37	7	128806685	128806685	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr7:128806685G>A	ENST00000289407.4	+	6	635	c.526G>A	c.(526-528)Gac>Aac	p.D176N		NM_178562.3	NP_848657.1	Q86UF1	TSN33_HUMAN	tetraspanin 33	176						integral to membrane				NS(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	14						CTGCTCAGAAGACAACCCCAG	0.522000													39	143					0	0	1	0	0
MLX	6945	broad.mit.edu	37	17	40723603	40723603	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:40723603G>A	ENST00000246912.4	+	8	932	c.879G>A	c.(877-879)ttG>ttA	p.L293L	MLX_ENST00000346833.4_Silent_p.L209L|MLX_ENST00000435881.2_Silent_p.L239L	NM_170607.2	NP_733752.1	Q9UH92	MLX_HUMAN	MLX, MAX dimerization protein	293					energy reserve metabolic process|negative regulation of transcription, DNA-dependent|positive regulation of cellular metabolic process	cytoplasm|nucleus	DNA binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			kidney(3)|large_intestine(4)|lung(1)|ovary(1)|urinary_tract(1)	10		all_cancers(22;4.26e-05)|Breast(137;0.000153)|all_epithelial(22;0.00148)		BRCA - Breast invasive adenocarcinoma(366;0.129)		TGCACCAATTGAAAAACCAGC	0.537000													52	122					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79229280	79229280	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr4:79229280G>C	ENST00000264895.6	+	15	2035	c.1595G>C	c.(1594-1596)aGa>aCa	p.R532T	FRAS1_ENST00000325942.6_Missense_Mutation_p.R532T|FRAS1_ENST00000264899.6_Missense_Mutation_p.R532T	NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	532					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						TTGGCCTGCAGAGATCCCCTC	0.577000													5	11					0	0	1	0	0
ZNF548	147694	broad.mit.edu	37	19	57911010	57911010	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:57911010G>A	ENST00000366197.5	+	3	1605	c.1355G>A	c.(1354-1356)aGa>aAa	p.R452K	ZNF548_ENST00000336128.7_Missense_Mutation_p.R464K|AC003002.6_ENST00000596400.1_Intron|AC003002.6_ENST00000600421.1_Intron|AC004076.7_ENST00000597410.1_Intron	NM_152909.3	NP_690873.2	Q8NEK5	ZN548_HUMAN	zinc finger protein 548	452					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TACGAGTGCAGAGAGTGTGGG	0.468000													18	32					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183714402	183714402	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr4:183714402G>A	ENST00000511685.1	+	26	6700	c.6577G>A	c.(6577-6579)Gaa>Aaa	p.E2193K	TENM3_ENST00000406950.2_Missense_Mutation_p.E2193K					teneurin transmembrane protein 3																		TCGGTTGGATGAAGATGGTTT	0.483000													20	41					0	0	1	0	0
ARHGAP12	94134	broad.mit.edu	37	10	32097634	32097634	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:32097634C>A	ENST00000375250.5	-	17	2460	c.2219G>T	c.(2218-2220)aGa>aTa	p.R740I	ARHGAP12_ENST00000492028.1_5'UTR|ARHGAP12_ENST00000375245.4_Missense_Mutation_p.R718I|ARHGAP12_ENST00000344936.2_Missense_Mutation_p.R770I|ARHGAP12_ENST00000396144.4_Missense_Mutation_p.R765I|ARHGAP12_ENST00000311380.4_Missense_Mutation_p.R718I	NM_001270696.1|NM_001270698.1	NP_001257625.1|NP_001257627.1	Q8IWW6	RHG12_HUMAN	Rho GTPase activating protein 12	770	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			NS(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(11)|lung(10)|skin(1)|urinary_tract(2)	31		Prostate(175;0.0199)				TGGCAACTGTCTGATTAGGTC	0.433000													47	136					2.74695e-27	2.91513e-27	1	1	0
WWTR1	25937	broad.mit.edu	37	3	149260194	149260194	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:149260194C>G	ENST00000465804.1	-	5	955	c.699G>C	c.(697-699)caG>caC	p.Q233H	WWTR1_ENST00000360632.3_Missense_Mutation_p.Q233H|WWTR1_ENST00000467467.1_Missense_Mutation_p.Q233H	NM_001168278.1	NP_001161750.1	Q9GZV5	WWTR1_HUMAN	WW domain containing transcription regulator 1	233	Gln-rich.				hippo signaling cascade|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of protein kinase activity|negative regulation of protein phosphorylation|positive regulation of cell proliferation|positive regulation of epithelial to mesenchymal transition|regulation of SMAD protein import into nucleus|stem cell division|transcription, DNA-dependent	cytoplasm	transcription coactivator activity			breast(5)|cervix(1)|endometrium(2)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)	23			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			GCCGCAGTTTCTGCTGCTGCT	0.577000			T	CAMTA1	epitheliod hemangioendothelioma								8	40					0	0	1	0	0
PAPD4	167153	broad.mit.edu	37	5	78944941	78944941	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:78944941C>T	ENST00000453514.1	+	10	1648	c.955C>T	c.(955-957)Cag>Tag	p.Q319*	PAPD4_ENST00000296783.3_Nonsense_Mutation_p.Q319*|PAPD4_ENST00000423041.2_Nonsense_Mutation_p.Q315*|PAPD4_ENST00000504233.1_Intron|PAPD4_ENST00000428308.2_Nonsense_Mutation_p.Q319*	NM_001114394.1	NP_001107866.1	Q6PIY7	GLD2_HUMAN	PAP associated domain containing 4	319					histone mRNA catabolic process|mRNA processing|RNA polyadenylation	cytoplasm	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity			biliary_tract(1)|breast(2)|endometrium(4)|kidney(3)|large_intestine(9)|lung(4)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	29		Lung NSC(167;0.00293)|all_lung(232;0.00323)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;8.61e-47)|Epithelial(54;1.32e-41)|all cancers(79;2.45e-36)		AAGTCACCATCAGATAAATGA	0.358000													10	26					0	0	1	0	0
GPR101	83550	broad.mit.edu	37	X	136113174	136113174	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrX:136113174C>T	ENST00000298110.1	-	1	659	c.660G>A	c.(658-660)cgG>cgA	p.R220R		NM_054021.1	NP_473362.1	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	220						integral to membrane|plasma membrane	G-protein coupled receptor activity			autonomic_ganglia(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(18)|ovary(3)|skin(1)|urinary_tract(1)	42	Acute lymphoblastic leukemia(192;0.000127)					CATGCTGCCTCCGGGCTGCAC	0.537000													33	22					0	0	1	0	0
CAPN5	726	broad.mit.edu	37	11	76795973	76795973	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:76795973C>T	ENST00000278559.3	+	2	230	c.41C>T	c.(40-42)tCa>tTa	p.S14L	CAPN5_ENST00000456580.2_Missense_Mutation_p.S14L|CAPN5_ENST00000531028.1_Missense_Mutation_p.S14L|CAPN5_ENST00000529629.1_Missense_Mutation_p.S14L	NM_004055.4	NP_004046.2	O15484	CAN5_HUMAN	calpain 5	14					proteolysis|signal transduction	intracellular	calcium-dependent cysteine-type endopeptidase activity			NS(1)|breast(2)|endometrium(2)|large_intestine(7)|lung(17)|urinary_tract(1)	30						CAGAACTACTCAGCCCTGAGG	0.637000													11	31					0	0	1	0	0
ATP1A2	477	broad.mit.edu	37	1	160097482	160097482	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:160097482G>A	ENST00000361216.3	+	8	978	c.889G>A	c.(889-891)Gct>Act	p.A297T	ATP1A2_ENST00000392233.3_Missense_Mutation_p.A297T	NM_000702.3	NP_000693.1	P50993	AT1A2_HUMAN	ATPase, Na+/K+ transporting, alpha 2 polypeptide	297					ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(30)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	69	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			CACAGGGGTCGCTGTATTCCT	0.577000													36	141					0	0	1	0	0
RB1	5925	broad.mit.edu	37	13	48936983	48936983	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr13:48936983C>T	ENST00000267163.4	+	8	889	c.751C>T	c.(751-753)Cga>Tga	p.R251*		NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1	251					androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(6)|p.R251*(5)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TGGTTCACCTCGAACACCCAG	0.343000		6	"""D, Mis, N, F, S"""		"""retinoblastoma, sarcoma, breast, small cell lung"""	"""retinoblastoma, sarcoma, breast, small cell lung"""			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			17	46					0	0	1	0	0
YAP1	10413	broad.mit.edu	37	11	102098267	102098267	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:102098267C>T	ENST00000282441.5	+	8	1619	c.1231C>T	c.(1231-1233)Cga>Tga	p.R411*	YAP1_ENST00000345877.2_Nonsense_Mutation_p.R361*|YAP1_ENST00000526343.1_Nonsense_Mutation_p.R357*|YAP1_ENST00000524575.1_Nonsense_Mutation_p.R233*|YAP1_ENST00000528834.1_3'UTR|YAP1_ENST00000531439.1_Nonsense_Mutation_p.R395*|YAP1_ENST00000537274.1_Nonsense_Mutation_p.R399*	NM_001130145.2|NM_001282101.1	NP_001123617.1|NP_001269030.1	P46937	YAP1_HUMAN	Yes-associated protein 1	411	Transactivation domain.				cell proliferation|cellular response to gamma radiation|contact inhibition|hippo signaling cascade|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription coactivator activity|transcription corepressor activity|transcription regulatory region DNA binding			central_nervous_system(1)|large_intestine(1)|lung(1)|ovary(1)	4	all_cancers(8;0.000575)|all_epithelial(12;0.00564)	Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.00936)	Lung(13;0.245)	BRCA - Breast invasive adenocarcinoma(274;0.0189)		CAGTGTCCCTCGAACCCCAGA	0.433000													8	17					0	0	1	0	0
CLUL1	27098	broad.mit.edu	37	18	627295	627295	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr18:627295G>C	ENST00000581619.1	+	5	1544	c.697G>C	c.(697-699)Gag>Cag	p.E233Q	CLUL1_ENST00000540035.1_Missense_Mutation_p.E260Q|CLUL1_ENST00000579494.1_Missense_Mutation_p.E208Q|CLUL1_ENST00000400606.2_Missense_Mutation_p.E208Q|CLUL1_ENST00000338387.7_Missense_Mutation_p.E208Q			Q15846	CLUL1_HUMAN	clusterin-like 1 (retinal)	208					cell death	extracellular region				NS(1)|breast(1)|endometrium(5)|large_intestine(5)|liver(2)|lung(7)|ovary(2)|skin(1)	24						GATGCAGCAAGAGTTTGACCA	0.408000													52	147					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39824885	39824885	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:39824885G>A	ENST00000564288.1	+	47	12970	c.12193G>A	c.(12193-12195)Gaa>Aaa	p.E4065K	MACF1_ENST00000372915.3_Missense_Mutation_p.E4070K|MACF1_ENST00000289893.4_Missense_Mutation_p.E2505K|MACF1_ENST00000476350.1_3'UTR|MACF1_ENST00000567887.1_Missense_Mutation_p.E4102K|MACF1_ENST00000317713.7_Missense_Mutation_p.E2003K|MACF1_ENST00000545844.1_Missense_Mutation_p.E2003K|MACF1_ENST00000361689.2_Missense_Mutation_p.E2003K|MACF1_ENST00000539005.1_Missense_Mutation_p.E2003K			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	4070					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TGACATAATGGAAATTGAAGG	0.423000													16	62					0	0	1	0	0
KIAA1456	57604	broad.mit.edu	37	8	12879157	12879157	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr8:12879157G>C	ENST00000524591.2	+	5	1458	c.969G>C	c.(967-969)tgG>tgC	p.W323C	KIAA1456_ENST00000447063.2_Intron	NM_001099677.1|NM_020844.2	NP_001093147.1|NP_065895.2	Q9P272	K1456_HUMAN	KIAA1456	323							methyltransferase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)	7						ACTTGGAGTGGCTGAGAGCAC	0.423000													4	41					0	0	1	0	0
IGHV3-33	28434	broad.mit.edu	37	14	106815856	106815856	+	RNA	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr14:106815856C>T	ENST00000390615.2	-	0	296																											TTACTTCCATCATACCATATA	0.517000													45	214					0	0	1	0	0
KIRREL3	84623	broad.mit.edu	37	11	126318913	126318913	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:126318913C>G	ENST00000525144.2	-	8	1237	c.988G>C	c.(988-990)Gac>Cac	p.D330H	KIRREL3_ENST00000525704.2_Missense_Mutation_p.D330H|KIRREL3_ENST00000529097.2_Missense_Mutation_p.D330H	NM_032531.3	NP_115920.1	Q8IZU9	KIRR3_HUMAN	kin of IRRE like 3 (Drosophila)	330	Ig-like C2-type 3.				hemopoiesis	extracellular region|integral to membrane|plasma membrane	protein binding			central_nervous_system(1)|endometrium(5)|large_intestine(11)|lung(8)|ovary(3)|prostate(1)	29	all_hematologic(175;0.145)	Lung NSC(97;0.0484)|all_lung(97;0.0522)|Medulloblastoma(222;0.0523)|Breast(109;0.0949)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;6.03e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.12)		CAGTAGACGTCAACCGTGCGG	0.577000													12	30					0	0	1	0	0
SCN3A	6328	broad.mit.edu	37	2	165956858	165956858	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:165956858C>G	ENST00000360093.3	-	22	4411	c.3920G>C	c.(3919-3921)aGa>aCa	p.R1307T	SCN3A_ENST00000409101.3_Missense_Mutation_p.R1258T|SCN3A_ENST00000283254.7_Missense_Mutation_p.R1307T	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	1307						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	TCTTAAAGCTCTTAATGTCCG	0.378000													7	66					0	0	1	0	0
PRKCD	5580	broad.mit.edu	37	3	53215603	53215603	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:53215603G>T	ENST00000394729.2	+	5	848	c.520G>T	c.(520-522)Gtg>Ttg	p.V174L	PRKCD_ENST00000330452.3_Missense_Mutation_p.V174L	NM_212539.1	NP_997704.1	Q05655	KPCD_HUMAN	protein kinase C, delta	174					activation of phospholipase C activity|cellular component disassembly involved in apoptosis|cellular senescence|interferon-gamma-mediated signaling pathway|intracellular signal transduction|mRNA metabolic process|negative regulation of insulin receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein binding|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of ceramide biosynthetic process|positive regulation of glucosylceramide catabolic process|positive regulation of protein dephosphorylation|positive regulation of sphingomyelin catabolic process|protein stabilization|regulation of receptor activity|termination of signal transduction	cytosol|endoplasmic reticulum|nucleoplasm	ATP binding|calcium-independent protein kinase C activity|enzyme activator activity|enzyme binding|insulin receptor substrate binding|metal ion binding|protein C-terminus binding			breast(1)|central_nervous_system(4)|endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Ovarian(412;0.0728)		OV - Ovarian serous cystadenocarcinoma(275;3.58e-08)|BRCA - Breast invasive adenocarcinoma(193;0.000142)|Kidney(197;0.00153)|KIRC - Kidney renal clear cell carcinoma(197;0.00173)		CTTCTGTTCTGTGTGCAAAGA	0.567000													19	59					5.3912e-06	5.48616e-06	1	1	0
NLE1	54475	broad.mit.edu	37	17	33463472	33463472	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:33463472G>A	ENST00000442241.4	-	8	912	c.873C>T	c.(871-873)aaC>aaT	p.N291N	NLE1_ENST00000586869.1_5'UTR|NLE1_ENST00000360831.5_Silent_p.N249N	NM_001014445.1|NM_018096.3	NP_001014445.1|NP_060566.2	Q9NVX2	NLE1_HUMAN	notchless homolog 1 (Drosophila)	291						nucleolus				NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|prostate(2)	22		Ovarian(249;0.17)				GGGCCATGGTGTTCACCCAGT	0.607000													30	119					0	0	1	0	0
MAPK8	5599	broad.mit.edu	37	10	49633961	49633961	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:49633961A>G	ENST00000374189.1	+	8	900	c.719A>G	c.(718-720)cAg>cGg	p.Q240R	MAPK8_ENST00000374182.3_Missense_Mutation_p.Q240R|MAPK8_ENST00000360332.3_Missense_Mutation_p.Q240R|MAPK8_ENST00000395611.3_Intron			P45983	MK08_HUMAN	mitogen-activated protein kinase 8	240	Protein kinase.				activation of pro-apoptotic gene products|cellular response to mechanical stimulus|induction of apoptosis by intracellular signals|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of apoptosis|negative regulation of protein binding|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of deacetylase activity|regulation of protein localization|regulation of sequence-specific DNA binding transcription factor activity|response to UV|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|histone deacetylase binding|histone deacetylase regulator activity|JUN kinase activity|protein binding			breast(1)|central_nervous_system(3)|endometrium(4)|kidney(1)|large_intestine(6)|liver(3)|lung(11)|ovary(1)|skin(1)|stomach(1)|urinary_tract(2)	34		Ovarian(717;0.0221)|Lung SC(717;0.113)|all_neural(218;0.116)		Epithelial(53;3.46e-65)|Lung(62;0.125)		GTTATTGAACAGCTTGGAACA	0.318000													9	44					0	0	1	0	0
LRPPRC	10128	broad.mit.edu	37	2	44170868	44170868	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:44170868G>A	ENST00000260665.7	-	23	2519	c.2462C>T	c.(2461-2463)tCc>tTc	p.S821F		NM_133259.3	NP_573566.2	P42704	LPPRC_HUMAN	leucine-rich pentatricopeptide repeat containing	821					mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			breast(3)|endometrium(3)|kidney(5)|large_intestine(9)|lung(15)|ovary(2)|prostate(2)|skin(2)	41		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TATGTTGGTGGATGGTTCTGC	0.358000													32	108					0	0	1	0	0
UBE3A	7337	broad.mit.edu	37	15	25616710	25616710	+	Nonsense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:25616710G>C	ENST00000232165.3	-	6	1267	c.611C>G	c.(610-612)tCa>tGa	p.S204*	UBE3A_ENST00000397954.2_Nonsense_Mutation_p.S207*|UBE3A_ENST00000566215.1_Nonsense_Mutation_p.S184*|UBE3A_ENST00000428984.2_Nonsense_Mutation_p.S184*|SNHG14_ENST00000554726.1_RNA|UBE3A_ENST00000438097.1_Nonsense_Mutation_p.S184*	NM_000462.3|NM_130839.2	NP_000453.2|NP_570854.1	Q05086	UBE3A_HUMAN	ubiquitin protein ligase E3A	207					brain development|interspecies interaction between organisms|protein K48-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(14)|lung(13)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	38		all_cancers(20;3.47e-21)|Breast(32;0.00123)		all cancers(64;2.78e-08)|Epithelial(43;8.85e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0155)|Lung(196;0.0616)		AGATGCTTCTGAGTCTTCTTC	0.408000													45	141					0	0	1	0	0
MRGPRF	116535	broad.mit.edu	37	11	68773667	68773667	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:68773667C>T	ENST00000309099.6	-	3	493	c.111G>A	c.(109-111)caG>caA	p.Q37Q	MRGPRF_ENST00000441623.1_Silent_p.Q37Q	NM_145015.4	NP_659452.3	Q96AM1	MRGRF_HUMAN	MAS-related GPR, member F	37						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(3)|lung(4)	7			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			GCATCGCGATCTGCTCGATGG	0.642000													11	31					0	0	1	0	0
FAP	2191	broad.mit.edu	37	2	163076436	163076436	+	Splice_Site	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:163076436C>G	ENST00000188790.4	-	7	621		c.e7-1		FAP_ENST00000443424.1_Splice_Site	NM_004460.2	NP_004451.2	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha						endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(34)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(4)	63						TACAAATTCTCTAGAAGGAAA	0.294000													16	28					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144857639	144857639	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:144857639C>G	ENST00000369359.4	-	42	6861	c.6823G>C	c.(6823-6825)Gaa>Caa	p.E2275Q	PDE4DIP_ENST00000369354.3_Missense_Mutation_p.E2139Q|PDE4DIP_ENST00000369356.4_Missense_Mutation_p.E2139Q|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.E2224Q|PDE4DIP_ENST00000313382.9_Missense_Mutation_p.E2033Q|PDE4DIP_ENST00000524974.1_5'UTR			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	2139					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		ATGGGCGTTTCTGAGCCAGGA	0.488000			T	PDGFRB	MPD								12	254					0	0	1	0	0
GRIP2	80852	broad.mit.edu	37	3	14563188	14563188	+	RNA	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:14563188C>T	ENST00000273083.3	-	0	738							Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2						synaptic transmission	cytosol|plasma membrane	protein binding			endometrium(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	25						AAGAGTGCCTCGTGGCTGCAC	0.672000													8	11					0	0	1	0	0
WNK4	65266	broad.mit.edu	37	17	40933043	40933043	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:40933043G>A	ENST00000246914.5	+	1	348	c.327G>A	c.(325-327)acG>acA	p.T109T		NM_032387.4	NP_115763.2	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	109					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(10)|ovary(3)|prostate(1)|skin(5)|stomach(1)	35		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		CCGAGGGCACGTGGACCGAGG	0.731000													5	17					0	0	1	0	0
TMCC1	23023	broad.mit.edu	37	3	129373852	129373852	+	Nonsense_Mutation	SNP	T	T	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:129373852T>A	ENST00000393238.3	-	5	1946	c.1606A>T	c.(1606-1608)Aaa>Taa	p.K536*	TMCC1_ENST00000426664.2_Nonsense_Mutation_p.K422*|TMCC1_ENST00000432054.2_Nonsense_Mutation_p.K212*|TMCC1_ENST00000329333.5_Nonsense_Mutation_p.K357*	NM_001017395.3	NP_001017395.2	O94876	TMCC1_HUMAN	transmembrane and coiled-coil domain family 1	536						integral to membrane			PLXND1/TMCC1(4)	breast(1)|endometrium(3)|large_intestine(8)|lung(12)|skin(1)	25						TACGCGATTTTTTCTTCCATG	0.423000													23	70					0	0	1	0	0
GOLGB1	2804	broad.mit.edu	37	3	121414111	121414111	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:121414111C>T	ENST00000393667.3	-	13	5369	c.5259G>A	c.(5257-5259)gaG>gaA	p.E1753E	GOLGB1_ENST00000340645.5_Silent_p.E1748E	NM_001256486.1	NP_001243415.1	Q14789	GOGB1_HUMAN	golgin B1	1748					Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(2)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(26)|liver(2)|lung(36)|ovary(7)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(13)	119				GBM - Glioblastoma multiforme(114;0.0989)		GAGAGTCTTTCTCAGACATTA	0.378000													42	99					0	0	1	0	0
FAM71F1	84691	broad.mit.edu	37	7	128356937	128356937	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr7:128356937C>G	ENST00000315184.5	+	2	373	c.320C>G	c.(319-321)tCg>tGg	p.S107W	FAM71F1_ENST00000469348.1_3'UTR|FAM71F1_ENST00000485070.1_Silent_p.L28L	NM_001282788.1|NM_032599.2	NP_001269717.1|NP_115988.1	Q96KD3	F71F1_HUMAN	family with sequence similarity 71, member F1	107										NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	18						GTGACCTCCTCGGTACCCTGC	0.587000													7	23					0	0	1	0	0
SEC16A	9919	broad.mit.edu	37	9	139358973	139358973	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:139358973G>A	ENST00000313050.7	-	7	4418	c.4345C>T	c.(4345-4347)Cat>Tat	p.H1449Y	SEC16A_ENST00000290037.6_Missense_Mutation_p.H1271Y|SEC16A_ENST00000371706.3_Missense_Mutation_p.H1271Y|SEC16A_ENST00000431893.2_Missense_Mutation_p.H1271Y	NM_014866.1	NP_055681.1	O15027	SC16A_HUMAN	SEC16 homolog A (S. cerevisiae)	1271					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				breast(1)|central_nervous_system(3)|endometrium(7)|kidney(5)|large_intestine(15)|lung(14)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		GCACAGACATGAGGCACTGAA	0.458000													20	66					0	0	1	0	0
IFT88	8100	broad.mit.edu	37	13	21217598	21217598	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr13:21217598G>A	ENST00000382778.4	+	20	2832	c.1714G>A	c.(1714-1716)Gaa>Aaa	p.E572K	IFT88_ENST00000351808.5_Missense_Mutation_p.E563K|IFT88_ENST00000319980.6_Missense_Mutation_p.E572K|IFT88_ENST00000537103.1_Missense_Mutation_p.E544K			Q13099	IFT88_HUMAN	intraflagellar transport 88 homolog (Chlamydomonas)	572					cilium morphogenesis	centriole|intraflagellar transport particle B|microtubule basal body|microtubule-based flagellum	protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	27		all_cancers(29;5.79e-25)|all_epithelial(30;2.57e-20)|all_lung(29;3.13e-16)|Lung SC(185;0.0262)|Ovarian(182;0.0825)|Hepatocellular(188;0.244)		all cancers(112;0.000667)|Epithelial(112;0.00119)|OV - Ovarian serous cystadenocarcinoma(117;0.0141)|Lung(94;0.0183)|LUSC - Lung squamous cell carcinoma(192;0.0528)		CATAAGATATGAATTAATGGA	0.318000													11	42					0	0	1	0	0
IL36A	27179	broad.mit.edu	37	2	113763586	113763586	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:113763586C>A	ENST00000259211.6	+	2	457	c.46C>A	c.(46-48)Cag>Aag	p.Q16K		NM_014440.1	NP_055255.1	Q9UHA7	IL36A_HUMAN	interleukin 36, alpha	16					immune response|inflammatory response	extracellular space	cytokine activity|interleukin-1 receptor binding			large_intestine(1)|lung(3)|ovary(2)|skin(1)|stomach(2)	9						GGGGAGCATTCAGGATATCAA	0.468000													29	45					3.69857e-22	3.90905e-22	1	1	0
AGL	178	broad.mit.edu	37	1	100358047	100358047	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:100358047G>T	ENST00000294724.4	+	24	3621	c.3143G>T	c.(3142-3144)tGt>tTt	p.C1048F	AGL_ENST00000370163.3_Missense_Mutation_p.C1048F|AGL_ENST00000370161.2_Missense_Mutation_p.C1032F|AGL_ENST00000361915.3_Missense_Mutation_p.C1048F|AGL_ENST00000361522.4_Missense_Mutation_p.C1031F|AGL_ENST00000370165.3_Missense_Mutation_p.C1048F|AGL_ENST00000361302.3_Missense_Mutation_p.C1032F	NM_000028.2	NP_000019.2	P35573	GDE_HUMAN	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	1048					glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(9)|lung(35)|ovary(1)|prostate(4)|skin(3)|urinary_tract(1)	69		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		GTTCAACTGTGTGGAGTAGGA	0.368000													15	40					2.32078e-09	2.41362e-09	1	1	0
FAM110B	90362	broad.mit.edu	37	8	59059267	59059267	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr8:59059267G>A	ENST00000361488.3	+	5	1358	c.478G>A	c.(478-480)Gcg>Acg	p.A160T	FAM110B_ENST00000520369.1_Intron	NM_147189.2	NP_671722.1	Q8TC76	F110B_HUMAN	family with sequence similarity 110, member B	160						microtubule organizing center|mitochondrion|nucleus				breast(1)|endometrium(3)|kidney(1)|large_intestine(10)|lung(9)|skin(2)	26		all_epithelial(80;0.025)|all_lung(136;0.0274)|Lung NSC(129;0.0355)				TCACTCCTTCGCGGAGTCCCT	0.692000													5	10					0	0	1	0	0
RNF180	285671	broad.mit.edu	37	5	63510308	63510308	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:63510308G>A	ENST00000389100.4	+	4	1227	c.1155G>A	c.(1153-1155)agG>agA	p.R385R	RNF180_ENST00000381081.2_Intron|RNF180_ENST00000296615.6_Silent_p.R385R	NM_001113561.1	NP_001107033.1	Q86T96	RN180_HUMAN	ring finger protein 180	385	Interaction with ZIC2 (By similarity).					integral to membrane|nuclear envelope	zinc ion binding			breast(1)|kidney(1)|large_intestine(4)|lung(9)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	20		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0848)|Colorectal(97;0.234)		Lung(70;0.114)		ATCTAAGAAGGAAACAACGAA	0.393000													16	55					0	0	1	0	0
FER1L5	90342	broad.mit.edu	37	2	97365429	97365429	+	RNA	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:97365429C>T	ENST00000457909.1	+	0	4256							A0AVI2	FR1L5_HUMAN	fer-1-like 5 (C. elegans)							integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(9)|large_intestine(9)|lung(6)|ovary(2)|prostate(2)|skin(1)|urinary_tract(2)	38						CTTTGGAGCTCATTGTGGGCT	0.527000													38	80					0	0	1	0	0
MTRR	4552	broad.mit.edu	37	5	7892992	7892992	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:7892992C>T	ENST00000264668.2	+	11	1634	c.1604C>T	c.(1603-1605)tCc>tTc	p.S535F	MTRR_ENST00000440940.2_Missense_Mutation_p.S508F	NM_002454.2|NM_024010.2	NP_002445.2|NP_076915.2	Q9UBK8	MTRR_HUMAN	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	535	FAD-binding FR-type.				methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			NS(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(14)|ovary(1)|prostate(3)|stomach(1)	31					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	ATACATGCATCCCATGAAGAC	0.448000													21	71					0	0	1	0	0
TRMT13	54482	broad.mit.edu	37	1	100614274	100614274	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:100614274C>T	ENST00000370141.2	+	11	1350	c.1344C>T	c.(1342-1344)ttC>ttT	p.F448F		NM_019083.2	NP_061956.2			tRNA methyltransferase 13 homolog (S. cerevisiae)																		AGAAGGGATTCAGTCCTGCTT	0.383000													16	63					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167689355	167689355	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:167689355T>C	ENST00000519204.1	+	28	7620	c.7502T>C	c.(7501-7503)gTg>gCg	p.V2501A	TENM2_ENST00000518659.1_Missense_Mutation_p.V2622A|TENM2_ENST00000545108.1_Missense_Mutation_p.V2621A|TENM2_ENST00000403607.2_Missense_Mutation_p.V2446A|TENM2_ENST00000520394.1_Missense_Mutation_p.V2383A					teneurin transmembrane protein 2																		CACTACTTTGTGAAGATTGGC	0.592000													5	10					0	0	1	0	0
ITGAL	3683	broad.mit.edu	37	16	30506048	30506048	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr16:30506048C>T	ENST00000356798.6	+	13	1560	c.1380C>T	c.(1378-1380)ttC>ttT	p.F460F	ITGAL_ENST00000568012.1_3'UTR|ITGAL_ENST00000358164.5_Silent_p.F377F|ITGAL_ENST00000433423.2_Intron	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	460					blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	GCTCTTATTTCGGTGGGGAGC	0.597000													12	27					0	0	1	0	0
CACNA1F	778	broad.mit.edu	37	X	49065842	49065842	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrX:49065842C>T	ENST00000376265.2	-	42	4927	c.4866G>A	c.(4864-4866)cgG>cgA	p.R1622R	CACNA1F_ENST00000376251.1_Silent_p.R1557R|CACNA1F_ENST00000323022.5_Silent_p.R1611R	NM_005183.2	NP_005174.2	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type, alpha 1F subunit	1622					axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			autonomic_ganglia(1)|breast(8)|central_nervous_system(3)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(4)|urinary_tract(1)	85					Verapamil(DB00661)	CCTGCAGGCTCCGCAGACCAG	0.607000													6	10					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39824525	39824525	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:39824525G>C	ENST00000564288.1	+	46	12877	c.12100G>C	c.(12100-12102)Gag>Cag	p.E4034Q	MACF1_ENST00000372915.3_Missense_Mutation_p.E4039Q|MACF1_ENST00000289893.4_Missense_Mutation_p.E2474Q|MACF1_ENST00000476350.1_3'UTR|MACF1_ENST00000567887.1_Missense_Mutation_p.E4071Q|MACF1_ENST00000317713.7_Missense_Mutation_p.E1972Q|MACF1_ENST00000545844.1_Missense_Mutation_p.E1972Q|MACF1_ENST00000361689.2_Missense_Mutation_p.E1972Q|MACF1_ENST00000539005.1_Missense_Mutation_p.E1972Q			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	4039					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AGTTCTCCAGGAGCAGCTTGC	0.512000													15	42					0	0	1	0	0
RRAGB	10325	broad.mit.edu	37	X	55784744	55784744	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrX:55784744G>A	ENST00000374941.4	+	10	1598	c.1009G>A	c.(1009-1011)Gat>Aat	p.D337N	RRAGB_ENST00000262850.7_Missense_Mutation_p.D365N	NM_006064.4	NP_006055.3	Q5VZM2	RRAGB_HUMAN	Ras-related GTP binding B	365				M -> V (in Ref. 1; CAA62132).	cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade|signal transduction	Golgi apparatus|lysosome|nucleus	GTP binding|protein binding	p.D365H(1)		breast(1)|endometrium(3)|large_intestine(5)|lung(3)|pancreas(1)|prostate(1)	14						GGAAAGAGTGGATGGACCAAA	0.403000													9	5					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32035515	32035515	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:32035515C>G	ENST00000375244.3	-	18	6668	c.6467G>C	c.(6466-6468)gGg>gCg	p.G2156A	TNXB_ENST00000375247.2_Missense_Mutation_p.G2156A			P22105	TENX_HUMAN	tenascin XB	2228					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						GTACTTGCGCCCAGGCTCCAG	0.677000													15	49					0	0	1	0	0
SLK	9748	broad.mit.edu	37	10	105780327	105780327	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:105780327C>A	ENST00000369755.3	+	17	3948	c.3403C>A	c.(3403-3405)Cag>Aag	p.Q1135K	SLK_ENST00000335753.4_Missense_Mutation_p.Q1104K	NM_014720.2	NP_055535.2	Q9H2G2	SLK_HUMAN	STE20-like kinase	1135					apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			kidney(1)|lung(1)|ovary(2)|skin(2)|stomach(2)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		GCGAGATCTTCAGTTGCAGTG	0.453000													15	56					3.41278e-10	3.55641e-10	1	1	0
LRRC37A3	374819	broad.mit.edu	37	17	62864606	62864606	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:62864606G>A	ENST00000584306.1	-	9	3557	c.3027C>T	c.(3025-3027)ctC>ctT	p.L1009L	LRRC37A3_ENST00000339474.5_Silent_p.L127L|LRRC37A3_ENST00000319651.5_Silent_p.L1009L|LRRC37A3_ENST00000400877.3_Silent_p.L47L	NM_199340.2	NP_955372.2	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	1009						integral to membrane				NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|liver(1)|lung(10)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						CAGTCATCATGAGAATGTTCT	0.328000													40	105					0	0	1	0	0
ADAMTS5	11096	broad.mit.edu	37	21	28302318	28302318	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr21:28302318C>T	ENST00000284987.5	-	7	2233	c.2112G>A	c.(2110-2112)gtG>gtA	p.V704V	AP001601.2_ENST00000426771.1_RNA	NM_007038.3	NP_008969.2	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 5	704	Cys-rich.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	72						AGCCAGTTCTCACACACTTCC	0.493000													48	75					0	0	1	0	0
NID2	22795	broad.mit.edu	37	14	52485839	52485839	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr14:52485839C>T	ENST00000216286.5	-	14	2967	c.2968G>A	c.(2968-2970)Gaa>Aaa	p.E990K	NID2_ENST00000541773.1_Missense_Mutation_p.E889K	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	990	Thyroglobulin type-1 1.					basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					CCAGGAACTTCATGACCATCA	0.602000													8	22					0	0	1	0	0
INHBA	3624	broad.mit.edu	37	7	41739721	41739721	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr7:41739721C>T	ENST00000242208.4	-	2	498	c.252G>A	c.(250-252)ctG>ctA	p.L84L	INHBA-AS1_ENST00000422822.1_RNA|AC005027.3_ENST00000416150.1_RNA|INHBA_ENST00000442711.1_Silent_p.L84L|INHBA-AS1_ENST00000415848.2_RNA|INHBA-AS1_ENST00000420821.1_RNA	NM_002192.2	NP_002183.1	P08476	INHBA_HUMAN	inhibin, beta A	84					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			biliary_tract(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(15)|lung(26)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						TGATCGCGTTCAGAAGCGCCG	0.517000										TSP Lung(11;0.080)			135	329					0	0	1	0	0
SFMBT2	57713	broad.mit.edu	37	10	7262479	7262479	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:7262479G>A	ENST00000361972.4	-	11	1314	c.1224C>T	c.(1222-1224)ttC>ttT	p.F408F	SFMBT2_ENST00000397167.1_Silent_p.F408F	NM_001018039.1	NP_001018049.1	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	408					regulation of transcription, DNA-dependent	nucleus				NS(2)|breast(3)|central_nervous_system(4)|endometrium(7)|kidney(2)|large_intestine(26)|lung(34)|ovary(5)|pancreas(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	99						TGTTCTTTGTGAAACCTCGAC	0.502000													18	70					0	0	1	0	0
TMEM132E	124842	broad.mit.edu	37	17	32959762	32959762	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:32959762G>C	ENST00000321639.5	+	7	1580	c.1252G>C	c.(1252-1254)Gag>Cag	p.E418Q		NM_207313.1	NP_997196.1	Q6IEE7	T132E_HUMAN	transmembrane protein 132E	418						integral to membrane				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(28)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	57				BRCA - Breast invasive adenocarcinoma(366;0.231)		GAGTGGAAAAGAGTCTCGAGG	0.567000													18	53					0	0	1	0	0
LNX2	222484	broad.mit.edu	37	13	28127506	28127506	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr13:28127506C>T	ENST00000316334.3	-	8	1746	c.1617G>A	c.(1615-1617)ctG>ctA	p.L539L		NM_153371.3	NP_699202.1	Q8N448	LNX2_HUMAN	ligand of numb-protein X 2	539	PDZ 3.						zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	31		Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.113)|all cancers(112;0.127)|Epithelial(112;0.248)		CACTGGCTTTCAGCATTGCAA	0.478000													15	52					0	0	1	0	0
LAYN	143903	broad.mit.edu	37	11	111430885	111430885	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:111430885G>A	ENST00000436913.2	+	6	793	c.392G>A	c.(391-393)gGa>gAa	p.G131E	LAYN_ENST00000375614.2_Missense_Mutation_p.G276E|LAYN_ENST00000533265.1_3'UTR|LAYN_ENST00000375615.3_Missense_Mutation_p.G284E|LAYN_ENST00000525126.1_3'UTR	NM_001258391.1	NP_001245320.1	Q6UX15	LAYN_HUMAN	layilin	284	C-type lectin.					cell surface|integral to membrane|ruffle	hyaluronic acid binding|sugar binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(3)|skin(1)	14		all_cancers(61;9.06e-10)|all_epithelial(67;1.34e-05)|Melanoma(852;1.74e-05)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Breast(348;0.086)		Epithelial(105;1.5e-06)|BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|all cancers(92;2.45e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0476)		CCTCACCAGGGAAACAGCCCG	0.498000													13	48					0	0	1	0	0
ANKRD44	91526	broad.mit.edu	37	2	197870475	197870475	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:197870475C>T	ENST00000328737.2	-	21	2291	c.2215G>A	c.(2215-2217)Gac>Aac	p.D739N	ANKRD44_ENST00000450567.1_Missense_Mutation_p.D739N|ANKRD44_ENST00000282272.8_Missense_Mutation_p.D756N|ANKRD44_ENST00000337207.5_Missense_Mutation_p.D739N			Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	764							protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(20)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	45			OV - Ovarian serous cystadenocarcinoma(117;0.246)			AAACAACAGTCCTCCTCAGAA	0.522000													10	126					0	0	1	0	0
UGT3A1	133688	broad.mit.edu	37	5	35957426	35957426	+	Silent	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:35957426G>C	ENST00000274278.3	-	5	1296	c.939C>G	c.(937-939)ctC>ctG	p.L313L	UGT3A1_ENST00000507113.1_Silent_p.L279L|UGT3A1_ENST00000503189.1_Silent_p.L313L|UGT3A1_ENST00000513233.1_5'UTR	NM_152404.3	NP_689617.3	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	313						integral to membrane	glucuronosyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|skin(4)	46	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GCATCTTCTTGAGGACTTCCT	0.493000													6	85					0	0	1	0	0
CFHR2	3080	broad.mit.edu	37	1	196928035	196928035	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:196928035T>C	ENST00000367415.5	+	5	738	c.638T>C	c.(637-639)aTt>aCt	p.I213T	CFHR2_ENST00000476712.2_Missense_Mutation_p.I197T|CFHR2_ENST00000367421.3_Missense_Mutation_p.I213T|CFHR2_ENST00000496448.1_3'UTR	NM_005666.2	NP_005657.1	P36980	FHR2_HUMAN	complement factor H-related 2		Sushi 4.					extracellular region				large_intestine(2)|ovary(1)|skin(3)	6						TCACAAGAAATTATGGAAAAA	0.274000													8	31					0	0	1	0	0
KCNIP2	30819	broad.mit.edu	37	10	103588900	103588900	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:103588900C>G	ENST00000358038.3	-	3	577	c.226G>C	c.(226-228)Gag>Cag	p.E76Q	KCNIP2_ENST00000355657.2_5'UTR|KCNIP2_ENST00000370046.1_Missense_Mutation_p.E44Q|KCNIP2_ENST00000343195.4_Missense_Mutation_p.E44Q|KCNIP2_ENST00000356640.2_Missense_Mutation_p.E94Q|KCNIP2_ENST00000461105.1_Missense_Mutation_p.E109Q|KCNIP2_ENST00000353068.3_Missense_Mutation_p.E44Q|KCNIP2_ENST00000348850.5_Missense_Mutation_p.E49Q	NM_173192.2|NM_173193.2|NM_173195.2	NP_775284.1|NP_775285.1|NP_775287.1	Q9NS61	KCIP2_HUMAN	Kv channel interacting protein 2	94				S -> R (in Ref. 10; BAB55052).	clustering of voltage-gated potassium channels|detection of calcium ion|muscle contraction|regulation of heart contraction|signal transduction|synaptic transmission	cytoplasm|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|calcium ion binding|ER retention sequence binding|identical protein binding|protein N-terminus binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	11		Colorectal(252;0.122)		Epithelial(162;4.93e-09)|all cancers(201;2.63e-07)		TGCAGCTGCTCCAGACCCTCA	0.617000													10	28					0	0	1	0	0
ZNF462	58499	broad.mit.edu	37	9	109690005	109690005	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:109690005C>T	ENST00000277225.5	+	3	4101	c.3812C>T	c.(3811-3813)tCa>tTa	p.S1271L	ZNF462_ENST00000457913.1_Missense_Mutation_p.S1271L|ZNF462_ENST00000441147.2_Missense_Mutation_p.S116L			Q96JM2	ZN462_HUMAN	zinc finger protein 462	1271					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						AGGCAGTGCTCATATACCTCC	0.522000													70	158					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	176833621	176833621	+	Silent	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:176833621G>C	ENST00000367654.3	-	23	3919	c.3708C>G	c.(3706-3708)ctC>ctG	p.L1236L	ASTN1_ENST00000361833.2_Silent_p.L1228L|ASTN1_ENST00000367657.3_Intron	NM_004319.1	NP_004310.1	O14525	ASTN1_HUMAN	astrotactin 1						cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						ACCAACTGCTGAGGTCCCCAA	0.522000													15	52					0	0	1	0	0
CNOT3	4849	broad.mit.edu	37	19	54649696	54649696	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:54649696G>A	ENST00000406403.1	+	8	2357	c.754G>A	c.(754-756)Gag>Aag	p.E252K	CNOT3_ENST00000358389.3_Missense_Mutation_p.E71K|CNOT3_ENST00000221232.5_Missense_Mutation_p.E252K			O75175	CNOT3_HUMAN	CCR4-NOT transcription complex, subunit 3	252					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(3)|prostate(7)|urinary_tract(3)	28	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CATGGAGGATGAGATCTTCAA	0.642000													15	25					0	0	1	0	0
KCTD16	57528	broad.mit.edu	37	5	143853407	143853407	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:143853407C>G	ENST00000507359.3	+	3	2108	c.1017C>G	c.(1015-1017)atC>atG	p.I339M	KCTD16_ENST00000512467.1_Missense_Mutation_p.I339M	NM_020768.3	NP_065819.1	Q68DU8	KCD16_HUMAN	potassium channel tetramerization domain containing 16							cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(5)|lung(9)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	21		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)			AGACCAACATCCAGACTCTGG	0.582000													19	63					0	0	1	0	0
OR6C2	341416	broad.mit.edu	37	12	55846882	55846882	+	Silent	SNP	G	G	A	rs142733366		TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:55846882G>A	ENST00000322678.1	+	1	885	c.885G>A	c.(883-885)gtG>gtA	p.V295V	RP11-110A12.2_ENST00000554049.1_RNA|RP11-110A12.2_ENST00000556750.1_RNA|RP11-110A12.2_ENST00000555138.1_RNA|RP11-110A12.2_ENST00000555146.1_RNA	NM_054105.1	NP_473446.1	Q9NZP2	OR6C2_HUMAN	olfactory receptor, family 6, subfamily C, member 2	295					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V295V(1)		kidney(2)|large_intestine(5)|lung(8)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	23						ACAAGCAAGTGAAACAAGCTT	0.398000													20	32					0	0	1	0	0
PRDX6	9588	broad.mit.edu	37	1	173455466	173455466	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:173455466G>A	ENST00000340385.5	+	4	604	c.472G>A	c.(472-474)Gat>Aat	p.D158N	PRDX6_ENST00000470017.1_3'UTR	NM_004905.2	NP_004896.1	P30041	PRDX6_HUMAN	peroxiredoxin 6	158	Thioredoxin.				cell redox homeostasis|phospholipid catabolic process	cytoplasmic membrane-bounded vesicle|cytosol|lysosome	peroxiredoxin activity|phospholipase A2 activity|protein binding			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|urinary_tract(1)	12						CAGGAACTTTGATGAGATTCT	0.443000													55	181					0	0	1	0	0
BCCIP	56647	broad.mit.edu	37	10	127512277	127512277	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:127512277G>A	ENST00000299130.3	+	1	163	c.151G>A	c.(151-153)Gag>Aag	p.E51K	BCCIP_ENST00000368759.5_Missense_Mutation_p.E51K|BCCIP_ENST00000429863.2_Missense_Mutation_p.E51K|BCCIP_ENST00000278100.6_Missense_Mutation_p.E51K	NM_078469.2	NP_510869.1	Q9P287	BCCIP_HUMAN	BRCA2 and CDKN1A interacting protein	51					cell cycle|DNA repair|neuroendocrine cell differentiation|regulation of cyclin-dependent protein kinase activity	nuclear cyclin-dependent protein kinase holoenzyme complex	kinase regulator activity|protein binding			breast(1)|kidney(2)|large_intestine(3)|lung(1)|ovary(1)	8		all_lung(145;0.00751)|Lung NSC(174;0.0115)|Colorectal(57;0.0846)|all_neural(114;0.0936)				tgaagaggacgaggTCATTGA	0.488000													9	52					0	0	1	0	0
AMER3	205147	broad.mit.edu	37	2	131521644	131521644	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:131521644C>G	ENST00000423981.1	+	2	2109	c.1999C>G	c.(1999-2001)Ctg>Gtg	p.L667V	AMER3_ENST00000321420.4_Missense_Mutation_p.L667V	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		AGGTGACACTCTGGATGCAGA	0.652000													8	17					0	0	1	0	0
EPOR	2057	broad.mit.edu	37	19	11489167	11489167	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:11489167C>T	ENST00000222139.6	-	8	1124	c.1020G>A	c.(1018-1020)ggG>ggA	p.G340G	EPOR_ENST00000592375.2_3'UTR	NM_000121.3	NP_000112.1	P19235	EPOR_HUMAN	erythropoietin receptor	340						extracellular region|integral to plasma membrane	erythropoietin receptor activity|identical protein binding			endometrium(1)|lung(2)|ovary(1)|urinary_tract(1)	5					Darbepoetin alfa(DB00012)|Epoetin alfa(DB00016)	CCTGCATCGTCCCCCAGCAGC	0.632000													17	21					0	0	1	0	0
BCCIP	56647	broad.mit.edu	37	10	127512271	127512271	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:127512271G>A	ENST00000299130.3	+	1	157	c.145G>A	c.(145-147)Gag>Aag	p.E49K	BCCIP_ENST00000368759.5_Missense_Mutation_p.E49K|BCCIP_ENST00000429863.2_Missense_Mutation_p.E49K|BCCIP_ENST00000278100.6_Missense_Mutation_p.E49K	NM_078469.2	NP_510869.1	Q9P287	BCCIP_HUMAN	BRCA2 and CDKN1A interacting protein	49					cell cycle|DNA repair|neuroendocrine cell differentiation|regulation of cyclin-dependent protein kinase activity	nuclear cyclin-dependent protein kinase holoenzyme complex	kinase regulator activity|protein binding			breast(1)|kidney(2)|large_intestine(3)|lung(1)|ovary(1)	8		all_lung(145;0.00751)|Lung NSC(174;0.0115)|Colorectal(57;0.0846)|all_neural(114;0.0936)				aaaggatgaagaggacgaggT	0.493000													10	53					0	0	1	0	0
THBS2	7058	broad.mit.edu	37	6	169648730	169648730	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:169648730C>T	ENST00000366787.3	-	4	640	c.391G>A	c.(391-393)Gac>Aac	p.D131N		NM_003247.2	NP_003238.2	P35442	TSP2_HUMAN	thrombospondin 2	131	Heparin-binding (Potential).|TSP N-terminal.				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			NS(3)|biliary_tract(1)|endometrium(8)|kidney(3)|large_intestine(23)|liver(1)|lung(56)|ovary(6)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	111		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		CGGGTGCCGTCAATCCAGTAG	0.652000													27	60					0	0	1	0	0
KLHL14	57565	broad.mit.edu	37	18	30350474	30350474	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr18:30350474C>A	ENST00000359358.4	-	2	519	c.81G>T	c.(79-81)tgG>tgT	p.W27C	KLHL14_ENST00000358095.4_Missense_Mutation_p.W27C|AC012123.1_ENST00000426194.1_Intron	NM_020805.1	NP_065856.1	Q9P2G3	KLH14_HUMAN	kelch-like family member 14	27						cytosol|endoplasmic reticulum membrane				breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(20)|ovary(2)	31						GCTGCTTCCTCCACAGCAGGT	0.642000													21	22					2.70639e-06	2.76488e-06	1	1	0
GPR133	283383	broad.mit.edu	37	12	131471828	131471828	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:131471828G>A	ENST00000261654.5	+	6	1238	c.679G>A	c.(679-681)Gag>Aag	p.E227K	GPR133_ENST00000535015.1_Missense_Mutation_p.E259K	NM_198827.3	NP_942122.2	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133	227					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(2)|endometrium(6)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|pancreas(6)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	67	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		TGCTTTCGATGAGTTCATCAT	0.542000													14	44					0	0	1	0	0
KRT15	3866	broad.mit.edu	37	17	39671846	39671846	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:39671846C>T	ENST00000254043.3	-	6	4710	c.1125G>A	c.(1123-1125)ctG>ctA	p.L375L	KRT15_ENST00000393974.3_Silent_p.L210L|KRT15_ENST00000393981.3_Silent_p.L210L|KRT15_ENST00000393976.2_Silent_p.L375L	NM_002275.3	NP_002266	P19012	K1C15_HUMAN	keratin 15	375	Coil 2.|Rod.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16		Breast(137;0.000286)				GGAGCTCACTCAGCTGGGCCT	0.592000													29	56					0	0	1	0	0
RGMB	285704	broad.mit.edu	37	5	98129101	98129101	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:98129101G>A	ENST00000308234.7	+	5	1483	c.1081G>A	c.(1081-1083)Gaa>Aaa	p.E361K	RGMB_ENST00000513185.1_Missense_Mutation_p.E320K	NM_001012761.2	NP_001012779.2	Q6NW40	RGMB_HUMAN	repulsive guidance molecule family member b	320					axon guidance|BMP signaling pathway|cell adhesion|positive regulation of transcription, DNA-dependent	anchored to plasma membrane|ER-Golgi intermediate compartment|membrane raft	identical protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(2)|upper_aerodigestive_tract(1)	10		all_cancers(142;2.76e-08)|all_epithelial(76;2.98e-11)|all_lung(232;0.000485)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0587)		CCCCCTGAGTGAACGCATCGA	0.637000													4	20					0	0	1	0	0
GFRA1	2674	broad.mit.edu	37	10	117884737	117884737	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:117884737G>C	ENST00000439649.3	-	5	1117	c.750C>G	c.(748-750)atC>atG	p.I250M	GFRA1_ENST00000369236.1_Missense_Mutation_p.I250M|GFRA1_ENST00000355422.6_Missense_Mutation_p.I255M|GFRA1_ENST00000544592.1_Missense_Mutation_p.I134M	NM_001145453.1	NP_001138925.1	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1	255					axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			endometrium(2)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)	26		Lung NSC(174;0.21)		all cancers(201;0.0337)		CTTACCTGCAGATGTAATTCG	0.537000													16	26					0	0	1	0	0
PLCH2	9651	broad.mit.edu	37	1	2419057	2419057	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:2419057G>A	ENST00000449969.1	+	8	1215	c.1054G>A	c.(1054-1056)Gac>Aac	p.D352N	PLCH2_ENST00000378488.3_Missense_Mutation_p.D379N|PLCH2_ENST00000419816.2_Missense_Mutation_p.D379N|PLCH2_ENST00000378486.3_Missense_Mutation_p.D379N|PLCH2_ENST00000288766.5_Intron			O75038	PLCH2_HUMAN	phospholipase C, eta 2	379	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(3)|skin(1)	20	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		GGATGGGCCCGACGGGGAGCC	0.567000													4	25					0	0	1	0	0
LEMD3	23592	broad.mit.edu	37	12	65563434	65563434	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:65563434C>G	ENST00000308330.2	+	1	84	c.58C>G	c.(58-60)Cag>Gag	p.Q20E	LEMD3_ENST00000541171.1_3'UTR	NM_001167614.1|NM_014319.4	NP_001161086.1|NP_055134.2	Q9Y2U8	MAN1_HUMAN	LEM domain containing 3	20	LEM.				negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway	integral to nuclear inner membrane|membrane fraction	DNA binding|nucleotide binding|protein binding			breast(1)|central_nervous_system(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)	36			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0104)		GCTTTTCTCTCAGCTCCGCCG	0.602000													2	4					0	0	1	0	0
MRPL38	64978	broad.mit.edu	37	17	73895341	73895341	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:73895341C>G	ENST00000309352.3	-	8	1441	c.904G>C	c.(904-906)Gat>Cat	p.D302H	RP11-552F3.10_ENST00000587267.1_RNA|MRPL38_ENST00000409963.3_Missense_Mutation_p.D118H	NM_032478.3	NP_115867.2	Q96DV4	RM38_HUMAN	mitochondrial ribosomal protein L38	302						actin cytoskeleton|mitochondrion|ribosome				ovary(1)|pancreas(1)|prostate(2)|skin(1)	5			all cancers(21;0.000154)|Epithelial(20;0.000156)|BRCA - Breast invasive adenocarcinoma(9;0.00936)|LUSC - Lung squamous cell carcinoma(166;0.154)			TTGTAGAAATCAAAAGTGCGG	0.557000													5	14					0	0	1	0	0
SLC6A11	6538	broad.mit.edu	37	3	10960123	10960123	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:10960123G>A	ENST00000254488.2	+	8	1171	c.1105G>A	c.(1105-1107)Gag>Aag	p.E369K		NM_014229.1	NP_055044.1	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 11	369					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(13)|ovary(1)|skin(4)	35				OV - Ovarian serous cystadenocarcinoma(96;0.229)		ACCCATTGCTGAGGTGGCAGA	0.567000													9	29					0	0	1	0	0
TBC1D12	23232	broad.mit.edu	37	10	96162370	96162370	+	Translation_Start_Site	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:96162370G>A	ENST00000225235.4	+	0	110					NM_015188.1	NP_056003.1	O60347	TBC12_HUMAN	TBC1 domain family, member 12							intracellular	Rab GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|upper_aerodigestive_tract(2)	20		Colorectal(252;0.0429)				CCCACCCCCAGATGGTGGGTC	0.697000													11	12					0	0	1	0	0
SH2D3C	10044	broad.mit.edu	37	9	130506924	130506924	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:130506924G>A	ENST00000314830.8	-	7	1832	c.1719C>T	c.(1717-1719)ggC>ggT	p.G573G	SH2D3C_ENST00000471939.1_5'UTR|SH2D3C_ENST00000429553.1_Silent_p.G219G|SH2D3C_ENST00000420366.1_Silent_p.G415G|SH2D3C_ENST00000373276.3_Silent_p.G505G|SH2D3C_ENST00000373277.4_Silent_p.G416G|SH2D3C_ENST00000373274.3_Silent_p.G413G	NM_170600.2	NP_733745.1	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C	573					JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						TGCGCAGAAGGCCCACCTCCA	0.612000													31	93					0	0	1	0	0
PHYKPL	85007	broad.mit.edu	37	5	177658513	177658513	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:177658513C>G	ENST00000308158.5	-	2	305	c.71G>C	c.(70-72)aGa>aCa	p.R24T	PHYKPL_ENST00000476170.2_Missense_Mutation_p.R24T	NM_153373.2	NP_699204.1			5-phosphohydroxy-L-lysine phospho-lyase																		AAAAAAGAGTCTGCAGGAAGA	0.547000													32	94					0	0	1	0	0
RABL6	55684	broad.mit.edu	37	9	139726762	139726762	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:139726762G>A	ENST00000371675.3	+	7	1185	c.300G>A	c.(298-300)aaG>aaA	p.K100K	RABL6_ENST00000371663.4_Silent_p.K216K|RABL6_ENST00000466096.1_3'UTR|RABL6_ENST00000371671.4_Silent_p.K215K|RABL6_ENST00000357466.2_Silent_p.K215K|RABL6_ENST00000432842.2_Silent_p.K177K|RABL6_ENST00000311502.7_Silent_p.K215K					RAB, member RAS oncogene family-like 6																		CTTCCATGAAGAACAGCTTCG	0.493000													25	58					0	0	1	0	0
CTR9	9646	broad.mit.edu	37	11	10789708	10789708	+	Splice_Site	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:10789708G>A	ENST00000361367.2	+	15	2386	c.1960G>A	c.(1960-1962)Gga>Aga	p.G654R		NM_014633.3	NP_055448.1	Q6PD62	CTR9_HUMAN	CTR9, Paf1/RNA polymerase II complex component	654					histone H2B ubiquitination|histone monoubiquitination	Cdc73/Paf1 complex|nuclear speck				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(12)|ovary(2)|pancreas(1)|stomach(1)	40				all cancers(16;1.64e-07)|Epithelial(150;2.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		CAATGGCATAGGTGATTATAA	0.343000													17	60					0	0	1	0	0
ADCY2	108	broad.mit.edu	37	5	7414870	7414870	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:7414870C>T	ENST00000338316.4	+	2	484	c.395C>T	c.(394-396)tCt>tTt	p.S132F		NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	132					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						GGCACCGTCTCTCCCTGGGAC	0.423000													10	78					0	0	1	0	0
DCBLD2	131566	broad.mit.edu	37	3	98538214	98538214	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:98538214G>A	ENST00000326840.6	-	8	1281	c.919C>T	c.(919-921)Caa>Taa	p.Q307*	DCBLD2_ENST00000326857.9_Nonsense_Mutation_p.Q307*	NM_080927.3	NP_563615.3	Q96PD2	DCBD2_HUMAN	discoidin, CUB and LCCL domain containing 2	307	F5/8 type C.				cell adhesion|intracellular receptor mediated signaling pathway|negative regulation of cell growth|wound healing	cell surface|integral to plasma membrane				breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|stomach(2)	25						GCTGTTATTTGAGGATCCGCG	0.448000													14	21					0	0	1	0	0
GOLGA3	2802	broad.mit.edu	37	12	133353621	133353621	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:133353621C>T	ENST00000204726.3	-	20	4336	c.3778G>A	c.(3778-3780)Gag>Aag	p.E1260K	GOLGA3_ENST00000456883.2_Missense_Mutation_p.E1260K|GOLGA3_ENST00000450791.2_Missense_Mutation_p.E1260K	NM_005895.3	NP_005886.2	Q08378	GOGA3_HUMAN	golgin A3	1260	Gln-rich.				intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		GCCCGGGCCTCGGCCAGCTCT	0.587000													9	15					0	0	1	0	0
TBC1D14	57533	broad.mit.edu	37	4	7016174	7016174	+	Splice_Site	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr4:7016174G>A	ENST00000409757.4	+	12	1771		c.e12-1		TBC1D14_ENST00000446947.2_Splice_Site|TBC1D14_ENST00000448507.1_Splice_Site|TBC1D14_ENST00000451522.2_Splice_Site|TBC1D14_ENST00000410031.1_Splice_Site	NM_020773.2	NP_065824.2	Q9P2M4	TBC14_HUMAN	TBC1 domain family, member 14							intracellular	Rab GTPase activator activity			breast(1)|endometrium(5)|large_intestine(4)|lung(9)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	22						TATCTCCCTAGATGTTGACTT	0.299000													4	7					0	0	1	0	0
SLITRK1	114798	broad.mit.edu	37	13	84454070	84454070	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr13:84454070C>G	ENST00000377084.2	-	1	2458	c.1573G>C	c.(1573-1575)Gac>Cac	p.D525H		NM_001281503.1|NM_052910.1	NP_001268432.1|NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	525						integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		CCGTGGAGGTCTATCTGGATG	0.557000													16	46					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179596906	179596906	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:179596906G>C	ENST00000589042.1	-	57	17014	c.16790C>G	c.(16789-16791)tCt>tGt	p.S5597C	TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.S4353C|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.S5280C|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5280							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AACTGCAGTAGACTCCACAAA	0.433000													59	151					0	0	1	0	0
SEMA3A	10371	broad.mit.edu	37	7	83823834	83823834	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr7:83823834C>T	ENST00000265362.4	-	1	383	c.69G>A	c.(67-69)caG>caA	p.Q23Q	SEMA3A_ENST00000436949.1_Silent_p.Q23Q	NM_006080.2	NP_006071.1	Q14563	SEM3A_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A						axon guidance	extracellular region|membrane	receptor activity			breast(3)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53						TCTTCCCATTCTGATAGTTTG	0.418000													37	104					0	0	1	0	0
PRKRIR	5612	broad.mit.edu	37	11	76066699	76066699	+	Splice_Site	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:76066699C>G	ENST00000260045.3	-	4	424		c.e4-1		PRKRIR_ENST00000531878.1_Splice_Site	NM_004705.2	NP_004696.2	O43422	P52K_HUMAN	protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)						negative regulation of cell proliferation|response to stress|signal transduction		DNA binding|metal ion binding|protein dimerization activity			cervix(1)|endometrium(3)|large_intestine(4)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	25						CATCTTCACTCTAAATGTCAA	0.323000													3	8					0	0	1	0	0
HSD3B1	3283	broad.mit.edu	37	1	120056980	120056980	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:120056980C>T	ENST00000235547.6	+	4	979	c.840C>T	c.(838-840)ctC>ctT	p.L280L	HSD3B1_ENST00000369413.3_Silent_p.L278L|HSD3B1_ENST00000528909.1_Silent_p.L278L	NM_000862.2	NP_000853.1	P14060	3BHS1_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	278					androgen biosynthetic process|estrogen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(18)|ovary(2)|prostate(1)|skin(1)	32	all_neural(166;0.219)	all_lung(203;3.16e-06)|Lung NSC(69;2.19e-05)|all_epithelial(167;0.000624)		Lung(183;0.0106)|LUSC - Lung squamous cell carcinoma(189;0.0554)	NADH(DB00157)|Trilostane(DB01108)	AGTTCGGCCTCCGCCTTGATT	0.473000													8	152					0	0	1	0	0
CD2AP	23607	broad.mit.edu	37	6	47544302	47544302	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:47544302G>C	ENST00000359314.5	+	7	1228	c.772G>C	c.(772-774)Gag>Cag	p.E258Q		NM_012120.2	NP_036252.1	Q9Y5K6	CD2AP_HUMAN	CD2-associated protein	258					cell division|mitosis|protein complex assembly|signal transduction|substrate-dependent cell migration, cell extension	cytoplasm|filamentous actin|nucleolus|plasma membrane|ruffle	SH3 domain binding|structural constituent of cytoskeleton			kidney(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	20			Lung(136;0.105)|LUSC - Lung squamous cell carcinoma(51;0.138)			TCAGAGTGTGGAGATAACAAA	0.303000													21	76					0	0	1	0	0
TLR5	7100	broad.mit.edu	37	1	223285449	223285449	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:223285449C>T	ENST00000540964.1	-	4	1386	c.925G>A	c.(925-927)Gag>Aag	p.E309K	TLR5_ENST00000342210.6_Missense_Mutation_p.E309K			O60602	TLR5_HUMAN	toll-like receptor 5	309					cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of toll-like receptor signaling pathway	integral to membrane|plasma membrane	interleukin-1 receptor binding|transmembrane receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32				GBM - Glioblastoma multiforme(131;0.0851)		TTGAGTGTCTCAAAGACTCGT	0.443000													51	62					0	0	1	0	0
STK31	56164	broad.mit.edu	37	7	23810669	23810669	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr7:23810669C>T	ENST00000354639.3	+	14	2154	c.1690C>T	c.(1690-1692)Caa>Taa	p.Q564*	STK31_ENST00000355870.3_Nonsense_Mutation_p.Q587*|STK31_ENST00000433467.2_Nonsense_Mutation_p.Q587*|STK31_ENST00000405627.3_3'UTR|STK31_ENST00000428484.1_Nonsense_Mutation_p.Q564*	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	587							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						TACATATAGTCAAGTACTGCA	0.348000													30	96					0	0	1	0	0
RANBP3L	202151	broad.mit.edu	37	5	36265595	36265595	+	Nonsense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:36265595G>C	ENST00000296604.3	-	5	781	c.296C>G	c.(295-297)tCa>tGa	p.S99*	RANBP3L_ENST00000502994.1_Nonsense_Mutation_p.S124*|RANBP3L_ENST00000515759.1_Nonsense_Mutation_p.S99*	NM_145000.3	NP_659437.3	Q86VV4	RNB3L_HUMAN	RAN binding protein 3-like	99					intracellular transport					endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|urinary_tract(1)	16	all_lung(31;4.52e-05)		Epithelial(62;0.0543)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.149)|Colorectal(62;0.202)			CACAAGAGCTGATGTCATAAA	0.299000													15	75					0	0	1	0	0
BCCIP	56647	broad.mit.edu	37	10	127512238	127512238	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:127512238G>A	ENST00000299130.3	+	1	124	c.112G>A	c.(112-114)Gac>Aac	p.D38N	BCCIP_ENST00000368759.5_Missense_Mutation_p.D38N|BCCIP_ENST00000429863.2_Missense_Mutation_p.D38N|BCCIP_ENST00000278100.6_Missense_Mutation_p.D38N	NM_078469.2	NP_510869.1	Q9P287	BCCIP_HUMAN	BRCA2 and CDKN1A interacting protein	38					cell cycle|DNA repair|neuroendocrine cell differentiation|regulation of cyclin-dependent protein kinase activity	nuclear cyclin-dependent protein kinase holoenzyme complex	kinase regulator activity|protein binding			breast(1)|kidney(2)|large_intestine(3)|lung(1)|ovary(1)	8		all_lung(145;0.00751)|Lung NSC(174;0.0115)|Colorectal(57;0.0846)|all_neural(114;0.0936)				tgaggatgaagacgatgatga	0.527000													5	59					0	0	1	0	0
TLR3	7098	broad.mit.edu	37	4	186997899	186997899	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr4:186997899G>A	ENST00000296795.3	+	2	230	c.126G>A	c.(124-126)ttG>ttA	p.L42L		NM_003265.2	NP_003256.1	O15455	TLR3_HUMAN	toll-like receptor 3		LRRNT.				activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(5)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	29		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		ACCTGAAGTTGACTCAGGTAC	0.498000													4	47					0	0	1	0	0
PCBP4	57060	broad.mit.edu	37	3	51994209	51994209	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:51994209C>T	ENST00000461554.1	-	7	714	c.383G>A	c.(382-384)cGa>cAa	p.R128Q	PCBP4_ENST00000395013.3_Missense_Mutation_p.R51Q|PCBP4_ENST00000322099.7_Missense_Mutation_p.R128Q|PCBP4_ENST00000428823.2_Missense_Mutation_p.R128Q|PCBP4_ENST00000471622.1_Missense_Mutation_p.R128Q|PCBP4_ENST00000484633.1_Missense_Mutation_p.R128Q|PCBP4_ENST00000355852.2_Missense_Mutation_p.R128Q|PCBP4_ENST00000395014.2_Missense_Mutation_p.R94Q	NM_001174100.1	NP_001167571.1	P57723	PCBP4_HUMAN	poly(rC) binding protein 4	128	KH 2.					cytoplasm|ribonucleoprotein complex	DNA binding|RNA binding			endometrium(2)|large_intestine(2)|lung(2)|prostate(1)|stomach(1)	8				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		CCTCACCTCTCGGATCTCCTT	0.592000													15	56					0	0	1	0	0
CHRNA4	1137	broad.mit.edu	37	20	61991019	61991019	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:61991019C>T	ENST00000370263.4	-	2	330	c.109G>A	c.(109-111)Gag>Aag	p.E37K	CHRNA4_ENST00000463705.1_Intron	NM_000744.6|NM_001256573.1	NP_000735.1|NP_001243502.1	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 (neuronal)	37					B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(19)|prostate(3)|skin(3)|soft_tissue(1)	33	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	AGCCGCTCCTCGGCGTGGGCC	0.667000													11	28					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158647509	158647509	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:158647509C>T	ENST00000368147.4	-	7	1108	c.928G>A	c.(928-930)Gag>Aag	p.E310K		NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)						actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					AGATTTCTCTCAAGTCCCTTG	0.453000													12	39					0	0	1	0	0
FCN1	2219	broad.mit.edu	37	9	137809709	137809709	+	Silent	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:137809709C>G	ENST00000371806.3	-	1	100	c.9G>C	c.(7-9)ctG>ctC	p.L3L		NM_002003.3	NP_001994.2	O00602	FCN1_HUMAN	ficolin (collagen/fibrinogen domain containing) 1	3					opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|receptor binding|sugar binding			endometrium(3)|kidney(3)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	37		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.46e-08)|Epithelial(140;6.01e-08)|all cancers(34;3.69e-07)		TGGCTCCACTCAGCTCCATGC	0.587000													21	51					0	0	1	0	0
IRX1	79192	broad.mit.edu	37	5	3600251	3600251	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:3600251C>T	ENST00000302006.3	+	2	1241	c.1189C>T	c.(1189-1191)Ccc>Tcc	p.P397S	CTD-2012M11.3_ENST00000559410.1_RNA	NM_024337.3	NP_077313.3	P78414	IRX1_HUMAN	iroquois homeobox 1	397						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|endometrium(5)|kidney(2)|large_intestine(5)|lung(18)|ovary(2)|pancreas(1)|prostate(5)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	43						CGTTGGCGCTCCCCACGCCGC	0.662000													7	39					0	0	1	0	0
CHRD	8646	broad.mit.edu	37	3	184103022	184103022	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:184103022C>T	ENST00000204604.1	+	14	2060	c.1814C>T	c.(1813-1815)tCa>tTa	p.S605L	CHRD_ENST00000450923.1_Missense_Mutation_p.S605L|EIF2B5_ENST00000444495.1_Intron|CHRD_ENST00000545352.1_Missense_Mutation_p.S235L|CHRD_ENST00000348986.3_Missense_Mutation_p.S565L	NM_003741.2	NP_003732.2	Q9H2X0	CHRD_HUMAN	chordin	605	CHRD 4.				BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			NS(1)|biliary_tract(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(23)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TTCTATGGCTCAGAGGTAAGG	0.582000													18	62					0	0	1	0	0
RB1	5925	broad.mit.edu	37	13	49047507	49047507	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr13:49047507C>G	ENST00000267163.4	+	24	2639	c.2501C>G	c.(2500-2502)tCa>tGa	p.S834*		NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1	834	Domain C; mediates interaction with E4F1.|Interaction with LIMD1.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(11)|p.R830fs*8(1)|p.S834*(1)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ATCTTAGTATCAATTGGTGAA	0.259000		6	"""D, Mis, N, F, S"""		"""retinoblastoma, sarcoma, breast, small cell lung"""	"""retinoblastoma, sarcoma, breast, small cell lung"""			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			25	81					0	0	1	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33596062	33596062	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:33596062G>T	ENST00000504830.1	-	17	2966	c.2631C>A	c.(2629-2631)tgC>tgA	p.C877*	ADAMTS12_ENST00000352040.3_Nonsense_Mutation_p.C792*|ADAMTS12_ENST00000504582.1_5'UTR	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	877	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						CCTTTTCATGGCACTTCTTCT	0.527000										HNSCC(64;0.19)			17	112					2.94398e-08	3.05563e-08	1	1	0
UBR1	197131	broad.mit.edu	37	15	43294862	43294862	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:43294862G>A	ENST00000290650.4	-	32	3628	c.3550C>T	c.(3550-3552)Cat>Tat	p.H1184Y	UBR1_ENST00000382177.2_3'UTR	NM_174916.2	NP_777576.1	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin 1	1184					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			NS(2)|endometrium(2)|kidney(7)|large_intestine(12)|lung(25)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	58		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)		AGGTCAACATGAATGCGCTGC	0.413000													13	44					0	0	1	0	0
AREL1	9870	broad.mit.edu	37	14	75143291	75143291	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr14:75143291G>A	ENST00000356357.4	-	6	1161	c.646C>T	c.(646-648)Cat>Tat	p.H216Y	AREL1_ENST00000557401.1_5'UTR	NM_001039479.1	NP_001034568.1			apoptosis resistant E3 ubiquitin protein ligase 1									p.H216D(1)									CTTACCTCATGAATGGACAAG	0.453000													23	113					0	0	1	0	0
TLN2	83660	broad.mit.edu	37	15	63029226	63029226	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:63029226G>C	ENST00000561311.1	+	28	3738	c.3508G>C	c.(3508-3510)Gag>Cag	p.E1170Q	TLN2_ENST00000559908.1_3'UTR|TLN2_ENST00000306829.6_Missense_Mutation_p.E1170Q			Q9Y4G6	TLN2_HUMAN	talin 2	1170	Ala-rich.				cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			NS(3)|breast(6)|central_nervous_system(3)|endometrium(8)|kidney(8)|large_intestine(20)|lung(34)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)	99						GCTCATTCAAGAGGCCAAGCA	0.577000													14	41					0	0	1	0	0
GPR50	9248	broad.mit.edu	37	X	150349067	150349067	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrX:150349067G>A	ENST00000218316.3	+	2	1081	c.1012G>A	c.(1012-1014)Gcc>Acc	p.A338T		NM_004224.3	NP_004215.2	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	338	Pro-rich.				cell-cell signaling	integral to plasma membrane	melatonin receptor activity			breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(6)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)	38	Acute lymphoblastic leukemia(192;6.56e-05)					CCTGGCCCGCGCCCGTGCCCA	0.567000													8	95					0	0	1	0	0
TNFSF13B	10673	broad.mit.edu	37	13	108959240	108959240	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr13:108959240C>T	ENST00000375887.4	+	6	990	c.812C>T	c.(811-813)tCa>tTa	p.S271L	TNFSF13B_ENST00000430559.1_Missense_Mutation_p.S252L	NM_006573.4	NP_006564.1	Q9Y275	TN13B_HUMAN	tumor necrosis factor (ligand) superfamily, member 13b	271					cell proliferation|immune response|signal transduction	extracellular space|integral to membrane|plasma membrane|soluble fraction	cytokine activity|tumor necrosis factor receptor binding			large_intestine(1)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	10	all_lung(23;0.000396)|all_neural(89;0.00256)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00902)|Lung SC(71;0.104)		all cancers(43;0.184)|BRCA - Breast invasive adenocarcinoma(86;0.19)			GCACAAATATCACTGGATGGA	0.393000													15	38					0	0	1	0	0
PHF3	23469	broad.mit.edu	37	6	64395407	64395407	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:64395407C>G	ENST00000262043.3	+	4	2124	c.1784C>G	c.(1783-1785)tCt>tGt	p.S595C	PHF3_ENST00000393387.1_Missense_Mutation_p.S595C|PHF3_ENST00000509330.1_Missense_Mutation_p.S595C			Q92576	PHF3_HUMAN	PHD finger protein 3	595					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			breast(7)|cervix(2)|endometrium(8)|kidney(7)|large_intestine(18)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(6)	75	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			TTAACTCATTCTTTGAGTGAT	0.378000													16	58					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151163897	151163897	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:151163897A>T	ENST00000282466.3	-	4	3871	c.3872T>A	c.(3871-3873)tTc>tAc	p.F1291Y		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	1291					cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AAGGGGTGGGAAGGGAAGCTC	0.433000													53	124					0	0	1	0	0
RALGAPA2	57186	broad.mit.edu	37	20	20563711	20563711	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:20563711T>A	ENST00000202677.7	-	20	2697	c.2690A>T	c.(2689-2691)gAt>gTt	p.D897V		NM_020343.3	NP_065076.2	Q2PPJ7	RGPA2_HUMAN	Ral GTPase activating protein, alpha subunit 2 (catalytic)						activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(25)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	54						ATTTGAAGCATCGGTGGGACT	0.463000													16	26					0	0	1	0	0
BRINP1	1620	broad.mit.edu	37	9	121930184	121930184	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:121930184C>T	ENST00000265922.3	-	8	1925	c.1464G>A	c.(1462-1464)ctG>ctA	p.L488L	BRINP1_ENST00000482797.1_Intron	NM_014618.2	NP_055433.2			bone morphogenetic protein/retinoic acid inducible neural-specific 1	488																	GCAGGTACTTCAGCTCCAGGT	0.577000													9	34					0	0	1	0	0
OR4C6	219432	broad.mit.edu	37	11	55433227	55433227	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:55433227C>T	ENST00000314259.3	+	1	614	c.585C>T	c.(583-585)ctC>ctT	p.L195L		NM_001004704.1	NP_001004704.1	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C, member 6	195					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|lung(49)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	71						TCCTGGGCCTCTTAGTTACCC	0.443000													35	78					0	0	1	0	0
SLC25A2	83884	broad.mit.edu	37	5	140682702	140682702	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:140682702C>T	ENST00000239451.4	-	1	910	c.731G>A	c.(730-732)gGg>gAg	p.G244E		NM_031947.2	NP_114153.1	Q9BXI2	ORNT2_HUMAN	solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2	244					mitochondrial ornithine transport|urea cycle	integral to membrane|mitochondrial inner membrane	L-ornithine transmembrane transporter activity			breast(3)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	19		all_lung(500;0.000249)|Lung NSC(810;0.0011)|Ovarian(839;0.00556)|Breast(839;0.0173)|all_hematologic(541;0.152)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.00204)	L-Ornithine(DB00129)	TGCCTGTTTCCCATACATGGA	0.403000													23	51					0	0	1	0	0
CRTAC1	55118	broad.mit.edu	37	10	99770957	99770957	+	Silent	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:99770957G>C	ENST00000370597.3	-	2	517	c.162C>G	c.(160-162)ctC>ctG	p.L54L	CRTAC1_ENST00000298819.4_Silent_p.L54L|CRTAC1_ENST00000370591.2_Silent_p.L54L	NM_018058.6	NP_060528.3	Q9NQ79	CRAC1_HUMAN	cartilage acidic protein 1	54						proteinaceous extracellular matrix	calcium ion binding			autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(6)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	35		Colorectal(252;0.24)		Epithelial(162;2.18e-10)|all cancers(201;3.27e-09)		CACCATAGTTGAGCTGGGTGG	0.537000													35	83					0	0	1	0	0
ARPC5	10092	broad.mit.edu	37	1	183599601	183599601	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:183599601C>T	ENST00000359856.6	-	3	454	c.388G>A	c.(388-390)Gaa>Aaa	p.E130K	ARPC5_ENST00000294742.6_Missense_Mutation_p.E133K|ARPC5_ENST00000462965.1_5'UTR|ARPC5_ENST00000367534.1_Missense_Mutation_p.E130K	NM_005717.3	NP_005708.1	O15511	ARPC5_HUMAN	actin related protein 2/3 complex, subunit 5, 16kDa	130					actin cytoskeleton organization|cellular component movement|regulation of actin filament polymerization	Arp2/3 protein complex|cell projection|cytoplasm	actin binding|structural constituent of cytoskeleton			cervix(1)|large_intestine(1)|lung(2)	4						CTTACCTTTTCATGCCATTGC	0.348000													12	53					0	0	1	0	0
CYP11B1	1584	broad.mit.edu	37	8	143959251	143959251	+	Splice_Site	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr8:143959251C>G	ENST00000377675.3	-	4	537		c.e4-1		CYP11B1_ENST00000517471.1_Intron|CYP11B1_ENST00000292427.4_Intron			P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 1						aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(10)|lung(36)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	67	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	AGCCACATTTCTGCAAAACTC	0.532000									Familial Hyperaldosteronism type I				12	41					0	0	1	0	0
ZBTB32	27033	broad.mit.edu	37	19	36206116	36206116	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:36206116C>T	ENST00000392197.2	+	3	906	c.588C>T	c.(586-588)ctC>ctT	p.L196L	ZBTB32_ENST00000262630.3_Silent_p.L196L			Q9Y2Y4	ZBT32_HUMAN	zinc finger and BTB domain containing 32	196					DNA repair|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleoplasm	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			large_intestine(5)|lung(1)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	14	all_lung(56;2.22e-07)|Lung NSC(56;3.47e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			AGAAACGCCTCCAAGCCCCTG	0.587000													18	40					0	0	1	0	0
SYCP2	10388	broad.mit.edu	37	20	58467098	58467098	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:58467098C>T	ENST00000357552.3	-	24	2536	c.2311G>A	c.(2311-2313)Gag>Aag	p.E771K	SYCP2_ENST00000371001.2_Missense_Mutation_p.E771K			Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	771					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			NS(4)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(14)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			AATTCTTTCTCTGCTTTTCTA	0.333000													15	35					0	0	1	0	0
ZC3H13	23091	broad.mit.edu	37	13	46594682	46594682	+	Nonsense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr13:46594682G>C	ENST00000242848.4	-	5	698	c.350C>G	c.(349-351)tCa>tGa	p.S117*	ZC3H13_ENST00000282007.3_Nonsense_Mutation_p.S117*			Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	117							nucleic acid binding|zinc ion binding			cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|lung(25)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	79		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		TCTCCCTCTTGAAGATTCTTT	0.284000													11	33					0	0	1	0	0
RFX6	222546	broad.mit.edu	37	6	117243302	117243302	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:117243302G>C	ENST00000332958.2	+	13	1441	c.1425G>C	c.(1423-1425)caG>caC	p.Q475H		NM_173560.3	NP_775831.2	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	475					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(29)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	59						TGGTAGAACAGAGAGTTATTA	0.378000													19	61					0	0	1	0	0
MS4A7	58475	broad.mit.edu	37	11	60154219	60154219	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:60154219C>T	ENST00000358246.1	+	3	370	c.177C>T	c.(175-177)atC>atT	p.I59I	MS4A14_ENST00000531787.1_Intron|MS4A7_ENST00000530234.2_Intron|MS4A7_ENST00000534016.1_Silent_p.I59I|MS4A7_ENST00000300184.3_Silent_p.I104I	NM_206938.1|NM_206940.1	NP_996821.1|NP_996823.1	Q9GZW8	MS4A7_HUMAN	membrane-spanning 4-domains, subfamily A, member 7	104						integral to membrane	receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(2)|lung(8)|ovary(1)|skin(1)	20						TCTCAATTATCTCTGGAAAAC	0.403000													24	55					0	0	1	0	0
C5orf45	51149	broad.mit.edu	37	5	179264605	179264605	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:179264605C>G	ENST00000292586.6	-	7	908	c.818G>C	c.(817-819)aGa>aCa	p.R273T	C5orf45_ENST00000518219.1_3'UTR|C5orf45_ENST00000520698.1_Intron|C5orf45_ENST00000523084.1_Missense_Mutation_p.R139T|SQSTM1_ENST00000376929.3_3'UTR|SQSTM1_ENST00000389805.4_3'UTR|C5orf45_ENST00000376931.2_Missense_Mutation_p.R218T|C5orf45_ENST00000523267.1_5'UTR|C5orf45_ENST00000403396.2_Intron|C5orf45_ENST00000518235.1_Intron	NM_016175.3	NP_057259.2	Q6NTE8	CE045_HUMAN	chromosome 5 open reading frame 45	273										breast(2)|endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)	12						GAGGCCTTCTCTTGAGGCCTG	0.632000													31	64					0	0	1	0	0
SLC26A6	65010	broad.mit.edu	37	3	48665891	48665891	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:48665891C>T	ENST00000358747.6	-	15	1963	c.1713G>A	c.(1711-1713)caG>caA	p.Q571Q	SLC26A6_ENST00000455886.2_Silent_p.Q556Q|SLC26A6_ENST00000337000.8_Silent_p.Q485Q|SLC26A6_ENST00000383733.3_Silent_p.Q592Q|SLC26A6_ENST00000395550.2_Silent_p.Q592Q|SLC26A6_ENST00000420764.2_Silent_p.Q592Q	NM_001040454.1	NP_001035544.1			solute carrier family 26 (anion exchanger), member 6										SLC26A6/PRKAR2A(2)	NS(1)|breast(1)|cervix(1)|endometrium(3)|large_intestine(1)|lung(11)|ovary(1)	19				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00609)		TCTCCTCTTTCTGCAGTTGCT	0.572000													38	96					0	0	1	0	0
ANKRD13A	88455	broad.mit.edu	37	12	110468561	110468561	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:110468561C>T	ENST00000261739.4	+	12	1512	c.1346C>T	c.(1345-1347)tCa>tTa	p.S449L	C12orf76_ENST00000546651.2_Intron	NM_033121.1	NP_149112.1	Q8IZ07	AN13A_HUMAN	ankyrin repeat domain 13A	449										endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(8)|lung(3)|urinary_tract(1)	16						CAGGCTGATTCAGGtaaaaaa	0.368000													7	8					0	0	1	0	0
SS18L2	51188	broad.mit.edu	37	3	42632421	42632421	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:42632421G>C	ENST00000447630.1	+	2	240	c.32G>C	c.(31-33)aGg>aCg	p.R11T	SEC22C_ENST00000417572.1_Intron|SS18L2_ENST00000011691.4_Missense_Mutation_p.R11T			Q9UHA2	S18L2_HUMAN	synovial sarcoma translocation gene on chromosome 18-like 2	11										prostate(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.214)		GACTGGCTGAGGGGCAAGGCG	0.672000													12	49					0	0	1	0	0
SETX	23064	broad.mit.edu	37	9	135153600	135153600	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:135153600G>A	ENST00000372169.2	-	21	6881	c.6699C>T	c.(6697-6699)ttC>ttT	p.F2233F	SETX_ENST00000224140.5_Silent_p.F2233F|SETX_ENST00000393220.1_Silent_p.F2233F			Q7Z333	SETX_HUMAN	senataxin	2233					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		GCAGTCTGCAGAAGCGAGCCA	0.458000													30	88					0	0	1	0	0
SLC26A5	375611	broad.mit.edu	37	7	103018061	103018061	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr7:103018061C>T	ENST00000306312.3	-	18	2232	c.1971G>A	c.(1969-1971)gtG>gtA	p.V657V	SLC26A5_ENST00000356767.4_Intron|SLC26A5_ENST00000354356.4_Silent_p.V90V|SLC26A5_ENST00000393723.1_Silent_p.V627V|SLC26A5_ENST00000393727.1_Silent_p.V659V|SLC26A5_ENST00000393730.1_Silent_p.V625V|SLC26A5_ENST00000393729.1_Silent_p.V620V|SLC26A5_ENST00000393735.2_Intron|SLC26A5_ENST00000432958.2_Silent_p.V625V|SLC26A5_ENST00000339444.6_Silent_p.V657V	NM_198999.2	NP_945350.1	P58743	S26A5_HUMAN	solute carrier family 26 (anion exchanger), member 5	657	STAS.				regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			endometrium(5)|kidney(2)|large_intestine(9)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)	43						CCAGAGTTTTCACTCCAACAG	0.443000													18	43					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51497406	51497406	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:51497406C>T	ENST00000371117.3	-	65	11897	c.11622G>A	c.(11620-11622)ctG>ctA	p.L3874L		NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	3874					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					CCAGACAGCTCAGAGCCAGCC	0.438000													14	43					0	0	1	0	0
C9orf72	203228	broad.mit.edu	37	9	27561630	27561630	+	Silent	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:27561630G>C	ENST00000380003.3	-	5	681	c.618C>G	c.(616-618)ctC>ctG	p.L206L	C9orf72_ENST00000379997.3_Silent_p.L206L|C9orf72_ENST00000488117.1_5'UTR	NM_001256054.1|NM_018325.3	NP_001242983.1|NP_060795.1	Q96LT7	CI072_HUMAN	chromosome 9 open reading frame 72	206										breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|ovary(4)|pancreas(1)	23		all_neural(11;7.57e-10)		LUSC - Lung squamous cell carcinoma(38;0.0001)|Lung(218;0.00016)		CATCATCATTGAGTACTGTAT	0.313000													11	41					0	0	1	0	0
TPO	7173	broad.mit.edu	37	2	1460027	1460027	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:1460027G>A	ENST00000345913.4	+	7	883	c.792G>A	c.(790-792)gaG>gaA	p.E264E	TPO_ENST00000349624.3_Silent_p.E264E|TPO_ENST00000346956.3_Silent_p.E264E|TPO_ENST00000329066.4_Silent_p.E264E|TPO_ENST00000337415.3_Silent_p.E264E|TPO_ENST00000382201.3_Silent_p.E264E|TPO_ENST00000497517.2_Intron|TPO_ENST00000382198.1_Silent_p.E264E	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	264					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	TGACTTGTGAGAACCAAAACC	0.443000													8	30					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3239741	3239741	+	Missense_Mutation	SNP	C	C	T	rs146955381	byFrequency	TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrX:3239741C>T	ENST00000217939.6	-	5	4139	c.3985G>A	c.(3985-3987)Gat>Aat	p.D1329N		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1329						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GTGGCAACATCATCCTTAATT	0.373000													41	35					0	0	1	0	0
PRG4	10216	broad.mit.edu	37	1	186281364	186281364	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:186281364G>A	ENST00000445192.2	+	11	3896	c.3851G>A	c.(3850-3852)aGa>aAa	p.R1284K	PRG4_ENST00000367486.3_Missense_Mutation_p.R1241K|PRG4_ENST00000367483.4_Missense_Mutation_p.R1243K|PRG4_ENST00000367484.3_Missense_Mutation_p.R813K|TPR_ENST00000367478.4_3'UTR|PRG4_ENST00000367485.4_Missense_Mutation_p.R1191K	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	1284					cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						TGCCCTGGAAGAAGGCCTGCT	0.403000													57	71					0	0	1	0	0
TICRR	90381	broad.mit.edu	37	15	90119340	90119340	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:90119340G>A	ENST00000268138.7	+	1	628	c.523G>A	c.(523-525)Gag>Aag	p.E175K	TICRR_ENST00000560985.1_Missense_Mutation_p.E175K|RP11-429B14.1_ENST00000559041.1_RNA					TOPBP1-interacting checkpoint and replication regulator																		GTCTGGGTGCGAGGCCCAGGC	0.662000													6	19					0	0	1	0	0
PIR	8544	broad.mit.edu	37	X	15474083	15474083	+	Nonsense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrX:15474083G>C	ENST00000380421.3	-	5	828	c.368C>G	c.(367-369)tCa>tGa	p.S123*	PIR_ENST00000476381.1_5'UTR|PIR_ENST00000380420.5_Nonsense_Mutation_p.S123*	NM_001018109.2|NM_003662.3	NP_001018119.1|NP_003653.1	O00625	PIR_HUMAN	pirin (iron-binding nuclear protein)	123					transcription from RNA polymerase II promoter	cytoplasm|nucleus	metal ion binding|protein binding|quercetin 2,3-dioxygenase activity|transcription cofactor activity			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	9	Hepatocellular(33;0.183)					CATCTTCTCTGAGCTCCTCAA	0.527000													24	146					0	0	1	0	0
AP3B1	8546	broad.mit.edu	37	5	77409639	77409639	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:77409639C>G	ENST00000255194.6	-	19	2361	c.2186G>C	c.(2185-2187)gGa>gCa	p.G729A	AP3B1_ENST00000519295.1_Missense_Mutation_p.G680A	NM_001271769.1	NP_001258698.1	O00203	AP3B1_HUMAN	adaptor-related protein complex 3, beta 1 subunit	729	Glu/Ser-rich.				endocytosis|melanosome organization	clathrin coated vesicle membrane|Golgi apparatus|membrane coat	protein phosphatase binding|protein transporter activity			breast(5)|central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(12)|lung(12)|prostate(1)|skin(2)|urinary_tract(1)	39		all_lung(232;0.000397)|Lung NSC(167;0.00106)|Ovarian(174;0.0105)|Prostate(461;0.215)		OV - Ovarian serous cystadenocarcinoma(54;8.23e-47)|Epithelial(54;2.74e-41)|all cancers(79;4.8e-36)		TGACTCCCGTCCACTCTCACT	0.453000									Hermansky-Pudlak syndrome				10	92					0	0	1	0	0
NHS	4810	broad.mit.edu	37	X	17750460	17750460	+	Missense_Mutation	SNP	G	G	C	rs140651691	byFrequency	TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrX:17750460G>C	ENST00000380060.3	+	8	5107	c.4769G>C	c.(4768-4770)aGc>aCc	p.S1590T	NHS_ENST00000398097.3_Missense_Mutation_p.S1434T	NM_198270.2	NP_938011.1	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome (congenital cataracts and dental anomalies)	1590						nucleus				breast(5)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(26)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	71	Hepatocellular(33;0.183)					CCTGCAGCCAGCAGCAGCCGC	0.592000													4	47					0	0	1	0	0
NELL1	4745	broad.mit.edu	37	11	21581919	21581919	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:21581919C>T	ENST00000298925.5	+	18	2208	c.2055C>T	c.(2053-2055)tgC>tgT	p.C685C	NELL1_ENST00000532434.1_Silent_p.C610C|NELL1_ENST00000325319.5_Silent_p.C600C|NELL1_ENST00000357134.5_Silent_p.C657C|NELL1_ENST00000529218.1_Intron			Q92832	NELL1_HUMAN	NEL-like 1 (chicken)	657	VWFC 3.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			NS(1)|breast(3)|endometrium(5)|kidney(3)|large_intestine(15)|lung(36)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	70						GTTCTGTCTGCTCCTGCAAGG	0.542000													14	20					0	0	1	0	0
GHRHR	2692	broad.mit.edu	37	7	31018736	31018736	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr7:31018736G>A	ENST00000409316.1	+	10	885	c.448G>A	c.(448-450)Gag>Aag	p.E150K	GHRHR_ENST00000326139.2_Silent_p.V383V|GHRHR_ENST00000461424.1_Intron|GHRHR_ENST00000409904.3_Silent_p.V319V			Q02643	GHRHR_HUMAN	growth hormone releasing hormone receptor	0					activation of adenylate cyclase activity by G-protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation|positive regulation of growth hormone secretion|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of multicellular organism growth|response to estrogen stimulus|response to glucocorticoid stimulus	cell surface|integral to membrane|nuclear inner membrane|nuclear matrix|nuclear outer membrane|plasma membrane|stored secretory granule	growth factor binding|growth hormone-releasing hormone receptor activity|peptide hormone binding			biliary_tract(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(3)|lung(18)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	35					Sermorelin(DB00010)	CCCTGGAGGTGAGGACTGAGA	0.592000													10	46					0	0	1	0	0
RHCE	6006	broad.mit.edu	37	1	25729193	25729193	+	Missense_Mutation	SNP	G	G	A	rs1053346		TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:25729193G>A	ENST00000349320.3	-	5	720	c.332C>T	c.(331-333)gCg>gTg	p.A111V	RHCE_ENST00000349438.4_Missense_Mutation_p.A127V|RHCE_ENST00000374352.2_Missense_Mutation_p.A111V|RHCE_ENST00000243186.6_Missense_Mutation_p.A127V|RHCE_ENST00000425135.1_Missense_Mutation_p.A127V|RHCE_ENST00000294413.7_Missense_Mutation_p.A127V|RHCE_ENST00000346452.4_Missense_Mutation_p.A127V|RHCE_ENST00000455194.1_Missense_Mutation_p.A127V|RHCE_ENST00000413854.1_Missense_Mutation_p.A127V|RHCE_ENST00000495048.1_5'UTR|RHCE_ENST00000340849.4_Missense_Mutation_p.A127V			P18577	RHCE_HUMAN	Rh blood group, CcEe antigens	127						integral to plasma membrane				endometrium(8)|large_intestine(6)|lung(3)	17		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0426)|OV - Ovarian serous cystadenocarcinoma(117;2.12e-27)|Colorectal(126;3.16e-08)|COAD - Colon adenocarcinoma(152;1.72e-06)|STAD - Stomach adenocarcinoma(196;0.00035)|KIRC - Kidney renal clear cell carcinoma(1967;0.000769)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|GBM - Glioblastoma multiforme(114;0.00458)|READ - Rectum adenocarcinoma(331;0.0649)		GACAGCACCCGCTGAGATCAG	0.552000													23	31					0	0	1	0	0
FOXD2	2306	broad.mit.edu	37	1	47904362	47904362	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:47904362C>G	ENST00000334793.5	+	1	2674	c.555C>G	c.(553-555)ttC>ttG	p.F185L		NM_004474.3	NP_004465.3	O60548	FOXD2_HUMAN	forkhead box D2	185					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			lung(4)	4				READ - Rectum adenocarcinoma(2;0.0908)		ACGACTGCTTCGTCAAGATCC	0.637000													28	81					0	0	1	0	0
CYB561	1534	broad.mit.edu	37	17	61514723	61514723	+	Silent	SNP	G	G	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:61514723G>T	ENST00000584031.1	-	2	485	c.186C>A	c.(184-186)atC>atA	p.I62I	CYB561_ENST00000582297.1_Silent_p.I62I|CYB561_ENST00000582034.1_Silent_p.I33I|CYB561_ENST00000392975.2_Silent_p.I62I|CYB561_ENST00000448884.2_Silent_p.I62I|CYB561_ENST00000581573.1_Silent_p.I62I|CYB561_ENST00000582997.1_Silent_p.I69I|CYB561_ENST00000392976.1_Silent_p.I62I|CYB561_ENST00000542042.1_Silent_p.I129I|CYB561_ENST00000360793.3_Silent_p.I62I			P49447	CY561_HUMAN	cytochrome b561	62	Cytochrome b561.				electron transport chain|transport	integral to plasma membrane	cytochrome-b5 reductase activity|ferric-chelate reductase activity|metal ion binding			lung(2)|ovary(1)|prostate(1)	4				READ - Rectum adenocarcinoma(1115;0.0689)		CCTGCAGGAAGATCAGGCCTA	0.647000													16	47					6.31663e-08	6.54312e-08	1	1	0
PPP1R16B	26051	broad.mit.edu	37	20	37524349	37524349	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:37524349C>T	ENST00000299824.1	+	4	652	c.463C>T	c.(463-465)Cag>Tag	p.Q155*	PPP1R16B_ENST00000373331.2_Nonsense_Mutation_p.Q155*	NM_015568.2	NP_056383.1	Q96T49	PP16B_HUMAN	protein phosphatase 1, regulatory subunit 16B	155					regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			biliary_tract(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(23)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	49		Myeloproliferative disorder(115;0.00878)				GATCCTCGTTCAGTAGTACGT	0.567000													9	18					0	0	1	0	0
SLC9A6	10479	broad.mit.edu	37	X	135126738	135126738	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrX:135126738G>A	ENST00000370695.4	+	16	1996	c.1961G>A	c.(1960-1962)gGa>gAa	p.G654E	SLC9A6_ENST00000370698.3_Missense_Mutation_p.G622E|SLC9A6_ENST00000370701.1_Missense_Mutation_p.G602E	NM_001042537.1	NP_001036002.1	Q92581	SL9A6_HUMAN	solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6	622					regulation of pH	early endosome membrane|endoplasmic reticulum membrane|integral to membrane|microsome|plasma membrane|recycling endosome membrane	sodium:hydrogen antiporter activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(18)|ovary(2)|upper_aerodigestive_tract(1)	33	Acute lymphoblastic leukemia(192;0.000127)					AGATTTATGGGAAACAGTTCT	0.468000													23	17					0	0	1	0	0
BLOC1S6	26258	broad.mit.edu	37	15	45884353	45884353	+	Translation_Start_Site	SNP	G	G	A	rs149605903		TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:45884353G>A	ENST00000568816.1	+	0	227				BLOC1S6_ENST00000564765.1_De_novo_Start_OutOfFrame|BLOC1S6_ENST00000220531.3_Missense_Mutation_p.D35N|BLOC1S6_ENST00000566753.1_Missense_Mutation_p.D35N|BLOC1S6_ENST00000562384.1_Intron|BLOC1S6_ENST00000565216.1_Intron|RP11-96O20.4_ENST00000564080.1_Intron|BLOC1S6_ENST00000565323.1_Missense_Mutation_p.D40N|BLOC1S6_ENST00000567740.1_Intron|BLOC1S6_ENST00000567461.1_Intron|BLOC1S6_ENST00000565409.1_De_novo_Start_OutOfFrame					biogenesis of lysosomal organelles complex-1, subunit 6, pallidin																		CACTTCTCCAGATGAAGGGTT	0.383000													15	38					0	0	1	0	0
IL12RB1	3594	broad.mit.edu	37	19	18174783	18174783	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:18174783G>A	ENST00000600835.2	-	14	1819	c.1521C>T	c.(1519-1521)ctC>ctT	p.L507L	IL12RB1_ENST00000593993.2_Silent_p.L507L			P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1		Fibronectin type-III 5.				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			endometrium(1)|kidney(1)|lung(3)|pancreas(1)|skin(2)	8						GCAGGCCACTGAGGGTAACTT	0.647000													9	19					0	0	1	0	0
SFTPB	6439	broad.mit.edu	37	2	85893860	85893860	+	Silent	SNP	C	C	T	rs45478492		TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:85893860C>T	ENST00000393822.3	-	5	408	c.309G>A	c.(307-309)acG>acA	p.T103T	SFTPB_ENST00000519937.2_Silent_p.T91T|SFTPB_ENST00000409383.1_Silent_p.T103T|SFTPB_ENST00000342375.3_Silent_p.T91T			P07988	PSPB_HUMAN	surfactant protein B	91	Saposin B-type 1.				organ morphogenesis|respiratory gaseous exchange|sphingolipid metabolic process	extracellular space|lysosome				central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|skin(3)	16						ACTTCCTCATCGTGTCCTGGG	0.632000													43	103					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9057637	9057637	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:9057637C>T	ENST00000397910.4	-	3	30012	c.29809G>A	c.(29809-29811)Gaa>Aaa	p.E9937K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9939	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTGATCACTTCAGTGATGATG	0.453000													64	115					0	0	1	0	0
ANKRD35	148741	broad.mit.edu	37	1	145567755	145567755	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:145567755G>A	ENST00000355594.4	+	13	3092	c.3005G>A	c.(3004-3006)tGa>tAa	p.*1002*		NM_144698.3	NP_653299.4	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	0										NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(9)|lung(16)|ovary(4)|prostate(3)|skin(2)|urinary_tract(1)	47	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GAAGAGGAGTGAGGCAGCCTC	0.478000													39	117					0	0	1	0	0
KLRC2	3822	broad.mit.edu	37	12	10587089	10587089	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:10587089C>T	ENST00000381902.2	-	3	333	c.327G>A	c.(325-327)caG>caA	p.Q109Q	NKG2-E_ENST00000539033.1_Silent_p.Q109Q|KLRC2_ENST00000536833.2_Silent_p.Q50Q|KLRC2_ENST00000381901.1_Intron	NM_002260.3	NP_002251.2	P26717	NKG2C_HUMAN	killer cell lectin-like receptor subfamily C, member 2	109					cellular defense response	integral to plasma membrane	sugar binding|transmembrane receptor activity			kidney(2)|large_intestine(1)|lung(6)|ovary(1)|skin(1)	11						ATGTACCTTTCTGCGTTCTTG	0.279000													13	100					0	0	1	0	0
A1CF	29974	broad.mit.edu	37	10	52619618	52619618	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:52619618C>G	ENST00000374001.2	-	2	222	c.83G>C	c.(82-84)gGa>gCa	p.G28A	A1CF_ENST00000395489.2_5'UTR|A1CF_ENST00000373997.3_Missense_Mutation_p.G28A|A1CF_ENST00000373995.3_5'UTR|A1CF_ENST00000282641.2_Missense_Mutation_p.G28A|A1CF_ENST00000395495.1_Missense_Mutation_p.G28A|A1CF_ENST00000373993.1_Missense_Mutation_p.G28A			Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor						cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						CAAGCTATATCCTGTGCGCTG	0.498000													15	43					0	0	1	0	0
SLC46A1	113235	broad.mit.edu	37	17	26732064	26732064	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:26732064G>A	ENST00000440501.1	-	2	746	c.651C>T	c.(649-651)gcC>gcT	p.A217A	SLC46A1_ENST00000321666.5_Silent_p.A217A|SLC46A1_ENST00000584729.1_5'UTR	NM_080669.4	NP_542400.2	Q96NT5	PCFT_HUMAN	solute carrier family 46 (folate transporter), member 1	217					cellular iron ion homeostasis|folic acid metabolic process	apical plasma membrane|cytoplasm|integral to membrane	folic acid binding|folic acid transporter activity|heme transporter activity			lung(5)	5	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)	Folic Acid(DB00158)	CTATCAGCAAGGCCAAGGCCA	0.607000													16	62					0	0	1	0	0
KIF23	9493	broad.mit.edu	37	15	69737198	69737198	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:69737198G>A	ENST00000260363.4	+	19	2566	c.2449G>A	c.(2449-2451)Gac>Aac	p.D817N	KIF23_ENST00000537891.1_Missense_Mutation_p.D530N|KIF23_ENST00000395392.2_Missense_Mutation_p.D810N|KIF23_ENST00000559279.1_Missense_Mutation_p.D713N|KIF23_ENST00000352331.4_Missense_Mutation_p.D713N|KIF23_ENST00000558585.1_Missense_Mutation_p.D530N	NM_138555.2	NP_612565.1	Q02241	KIF23_HUMAN	kinesin family member 23	817					blood coagulation|cytokinesis|microtubule-based movement|mitosis|mitotic spindle elongation	cytosol|kinesin complex|microtubule|midbody|nucleoplasm|spindle	ATP binding|microtubule motor activity|protein binding			central_nervous_system(1)|endometrium(4)|large_intestine(7)|lung(6)|prostate(2)|skin(1)	21						CTCTGCAGGAGACAGATGGGT	0.453000													10	65					0	0	1	0	0
PRKD3	23683	broad.mit.edu	37	2	37513444	37513444	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:37513444C>A	ENST00000379066.1	-	6	1548	c.786G>T	c.(784-786)aaG>aaT	p.K262N	PRKD3_ENST00000234179.2_Missense_Mutation_p.K262N			O94806	KPCD3_HUMAN	protein kinase D3	262					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			breast(3)|central_nervous_system(2)|kidney(3)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33		all_hematologic(82;0.21)				ACATTACCATCTTTTCCATCC	0.433000													14	53					1.15088e-07	1.18506e-07	1	1	0
SLC27A5	10998	broad.mit.edu	37	19	59012064	59012064	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:59012064C>T	ENST00000263093.2	-	5	1301	c.1192G>A	c.(1192-1194)Gac>Aac	p.D398N	SLC27A5_ENST00000601355.1_Missense_Mutation_p.D314N	NM_012254.2	NP_036386.1	Q9Y2P5	S27A5_HUMAN	solute carrier family 27 (fatty acid transporter), member 5	398					bile acid and bile salt transport|bile acid biosynthetic process|very long-chain fatty acid metabolic process	endoplasmic reticulum membrane|integral to membrane	ATP binding|cholate-CoA ligase activity|long-chain fatty acid-CoA ligase activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	19		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.181)		TGTGTCCGGTCCTCTGGTTGC	0.572000													17	22					0	0	1	0	0
CECR6	27439	broad.mit.edu	37	22	17601328	17601328	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr22:17601328C>T	ENST00000331437.3	-	1	815	c.690G>A	c.(688-690)tgG>tgA	p.W230*	CECR6_ENST00000399875.1_Intron	NM_031890.3	NP_114096.1	Q9BXQ6	CECR6_HUMAN	cat eye syndrome chromosome region, candidate 6	230										haematopoietic_and_lymphoid_tissue(1)	1		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.221)		CAGTGGCGATCCAGGAGCACC	0.701000													3	6					0	0	1	0	0
PDE4B	5142	broad.mit.edu	37	1	66834533	66834533	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:66834533C>T	ENST00000423207.2	+	14	2166	c.1681C>T	c.(1681-1683)Cgg>Tgg	p.R561W	PDE4B_ENST00000480109.2_Missense_Mutation_p.R343W|PDE4B_ENST00000371049.3_Missense_Mutation_p.R576W|PDE4B_ENST00000329654.4_Missense_Mutation_p.R576W|PDE4B_ENST00000371045.5_Missense_Mutation_p.R404W	NM_001037340.1	NP_001032417.1	Q07343	PDE4B_HUMAN	phosphodiesterase 4B, cAMP-specific	576					signal transduction	cytosol|insoluble fraction|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(14)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	37					Adenosine monophosphate(DB00131)|Amrinone(DB01427)|Caffeine(DB00201)|Cilostazol(DB01166)|Dyphylline(DB00651)|Enprofylline(DB00824)|Papaverine(DB01113)|Pentoxifylline(DB00806)|Theophylline(DB00277)	GGAATTGTATCGGCAATGGAC	0.463000													16	70					0	0	1	0	0
RHOA	387	broad.mit.edu	37	3	49397721	49397721	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:49397721C>G	ENST00000418115.1	-	5	887	c.503G>C	c.(502-504)aGa>aCa	p.R168T	RHOA_ENST00000422781.1_3'UTR|RHOA_ENST00000454011.2_3'UTR	NM_001664.2	NP_001655.1	P61586	RHOA_HUMAN	ras homolog family member A	168					axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding			cervix(1)|kidney(1)|large_intestine(5)|lung(1)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	12				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)	AAAAACCTCTCTCACTCCATC	0.493000													40	104					0	0	1	0	0
BAG1	573	broad.mit.edu	37	9	33256861	33256861	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:33256861C>T	ENST00000472232.3	-	5	909	c.823G>A	c.(823-825)Gat>Aat	p.D275N	BAG1_ENST00000467389.2_5'UTR|BAG1_ENST00000379704.2_Missense_Mutation_p.D160N	NM_001172415.1|NM_004323.5	NP_001165886.1|NP_004314	Q99933	BAG1_HUMAN	BCL2-associated athanogene	275	BAG.|Interaction with PPP1R15A.				anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway|chaperone cofactor-dependent protein refolding	cytoplasm|intermediate filament cytoskeleton|nucleus	protein binding|receptor signaling protein activity			endometrium(1)|large_intestine(3)|lung(3)|ovary(1)	8			LUSC - Lung squamous cell carcinoma(29;0.00506)			ACTCTCCTATCAAGTTTGCAG	0.428000													22	66					0	0	1	0	0
AKAP12	9590	broad.mit.edu	37	6	151671704	151671704	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:151671704C>T	ENST00000402676.2	+	4	2418	c.2178C>T	c.(2176-2178)gaC>gaT	p.D726D	AKAP12_ENST00000253332.1_Silent_p.D726D|AKAP12_ENST00000354675.6_Silent_p.D628D|AKAP12_ENST00000359755.5_Silent_p.D621D	NM_005100.3	NP_005091.2	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12	726					G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	68		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		CGGGGACAGACGGGATCCTTG	0.587000													40	101					0	0	1	0	0
ECM1	1893	broad.mit.edu	37	1	150484937	150484937	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:150484937G>A	ENST00000369047.4	+	8	1318	c.1193G>A	c.(1192-1194)cGt>cAt	p.R398H	ECM1_ENST00000470432.1_3'UTR|ECM1_ENST00000369049.4_Missense_Mutation_p.R425H|ECM1_ENST00000346569.6_Missense_Mutation_p.R273H	NM_004425.3	NP_004416.2	Q16610	ECM1_HUMAN	extracellular matrix protein 1	398	2 X approximate repeats.				angiogenesis|biomineral tissue development|negative regulation of bone mineralization|negative regulation of peptidase activity|ossification|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade	proteinaceous extracellular matrix	laminin binding|protease binding|protein C-terminus binding|signal transducer activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(3)|urinary_tract(1)	22	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.29e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			TGCTTTGCCCGTCGGGCTCCT	0.567000													23	104					0	0	1	0	0
INADL	10207	broad.mit.edu	37	1	62263049	62263049	+	Nonsense_Mutation	SNP	C	C	T	rs117405402	byFrequency	TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:62263049C>T	ENST00000371158.2	+	11	1465	c.1351C>T	c.(1351-1353)Cga>Tga	p.R451*	INADL_ENST00000316485.6_Nonsense_Mutation_p.R451*	NM_176877.2	NP_795352	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	451	PDZ 3.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						AACCCTAGTTCGAAGGAAGAC	0.448000													33	84					0	0	1	0	0
C8orf34	116328	broad.mit.edu	37	8	69351819	69351819	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr8:69351819G>A	ENST00000337103.4	+	1	1672	c.80G>A	c.(79-81)cGt>cAt	p.R27H	C8orf34_ENST00000349492.3_3'UTR|C8orf34_ENST00000518698.1_Missense_Mutation_p.R138H|C8orf34_ENST00000539993.1_Missense_Mutation_p.R52H|C8orf34_ENST00000523686.1_Missense_Mutation_p.R52H|C8orf34_ENST00000348340.2_Missense_Mutation_p.R52H			Q49A92	CH034_HUMAN	chromosome 8 open reading frame 34	52					signal transduction		cAMP-dependent protein kinase regulator activity			NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(9)|lung(12)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	36			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			CAAGGGAACCGTGGACAACTT	0.403000													17	38					0	0	1	0	0
SLK	9748	broad.mit.edu	37	10	105780291	105780291	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:105780291C>T	ENST00000369755.3	+	17	3912	c.3367C>T	c.(3367-3369)Cag>Tag	p.Q1123*	SLK_ENST00000335753.4_Nonsense_Mutation_p.Q1092*	NM_014720.2	NP_055535.2	Q9H2G2	SLK_HUMAN	STE20-like kinase	1123					apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			kidney(1)|lung(1)|ovary(2)|skin(2)|stomach(2)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		GAGAATGGCTCAGCATCAGAA	0.393000													12	46					0	0	1	0	0
NDRG3	57446	broad.mit.edu	37	20	35310978	35310978	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:35310978C>T	ENST00000373803.2	-	7	443	c.387G>A	c.(385-387)ctG>ctA	p.L129L	NDRG3_ENST00000349004.1_Silent_p.L129L|NDRG3_ENST00000359675.2_Silent_p.L117L|NDRG3_ENST00000373773.3_Silent_p.L34L|NDRG3_ENST00000540765.1_Silent_p.L25L			Q9UGV2	NDRG3_HUMAN	NDRG family member 3	129					cell differentiation|negative regulation of cell growth|spermatogenesis	cytoplasm				endometrium(4)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)	12		Myeloproliferative disorder(115;0.00878)				TGATGCTTTTCAGGCTGTGAA	0.453000													39	48					0	0	1	0	0
PCSK4	54760	broad.mit.edu	37	19	1487786	1487786	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:1487786G>A	ENST00000300954.5	-	5	652	c.591C>T	c.(589-591)aaC>aaT	p.N197N	PCSK4_ENST00000587784.1_5'UTR	NM_017573.3	NP_060043.2	Q6UW60	PCSK4_HUMAN	proprotein convertase subtilisin/kexin type 4	197	Catalytic (By similarity).				proteolysis	integral to membrane	serine-type endopeptidase activity			cervix(2)|endometrium(2)|kidney(1)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	15		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGCTCACCGGTTCTCTTTGC	0.682000													6	3					0	0	1	0	0
KCNA3	3738	broad.mit.edu	37	1	111216259	111216259	+	Silent	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:111216259C>G	ENST00000369769.2	-	1	1396	c.1173G>C	c.(1171-1173)ctG>ctC	p.L391L		NM_002232.3	NP_002223.3	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 3	391						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(7)|ovary(4)|pancreas(1)|prostate(3)|skin(1)	38		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		TGGACGCCTTCAGCGTTTGCC	0.587000													28	83					0	0	1	0	0
MROH5	389690	broad.mit.edu	37	8	142490071	142490071	+	RNA	SNP	G	G	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr8:142490071G>T	ENST00000430863.1	-	0	994					NM_207414.2	NP_997297.2			maestro heat-like repeat family member 5																		TCTCCTGACCGTGGCACCGTT	0.597000													10	35					1.15088e-07	1.18506e-07	1	1	0
FAM63A	55793	broad.mit.edu	37	1	150972348	150972348	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:150972348G>A	ENST00000361936.5	-	7	1782	c.828C>T	c.(826-828)ctC>ctT	p.L276L	FAM63A_ENST00000493834.2_Silent_p.L181L|FAM63A_ENST00000470877.1_5'UTR|FAM63A_ENST00000312210.5_Silent_p.L134L|FAM63A_ENST00000361738.6_Silent_p.L324L	NM_018379.4	NP_060849	Q8N5J2	FA63A_HUMAN	family with sequence similarity 63, member A	276							protein binding			breast(1)|endometrium(3)|large_intestine(4)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	23	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CTTCTGTCACGAGGTTGGTGT	0.493000													8	39					0	0	1	0	0
GBP5	115362	broad.mit.edu	37	1	89735197	89735197	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:89735197G>A	ENST00000343435.5	-	3	578	c.42C>T	c.(40-42)atC>atT	p.I14I	RP4-620F22.2_ENST00000437128.1_RNA|GBP5_ENST00000370459.3_Silent_p.I14I	NM_001134486.2|NM_052942.3	NP_001127958.1|NP_443174.1	Q96PP8	GBP5_HUMAN	guanylate binding protein 5	14						plasma membrane	GTP binding|GTPase activity	p.I14I(1)		breast(1)|endometrium(1)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)	24				all cancers(265;0.00784)|Epithelial(280;0.0286)		TAAAGTTCTCGATGAGGCACA	0.478000													44	132					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3239561	3239561	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrX:3239561C>T	ENST00000217939.6	-	5	4319	c.4165G>A	c.(4165-4167)Ggg>Agg	p.G1389R		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1389						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TGTAGCCTCCCAGGCTGGGCC	0.507000													15	8					0	0	1	0	0
CCDC63	160762	broad.mit.edu	37	12	111296402	111296402	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:111296402G>C	ENST00000308208.5	+	4	434	c.192G>C	c.(190-192)aaG>aaC	p.K64N	CCDC63_ENST00000550317.1_3'UTR|CCDC63_ENST00000552694.1_5'UTR|CCDC63_ENST00000545036.1_Missense_Mutation_p.K24N	NM_152591.1	NP_689804.1	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	64										NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(1)	39						AGGAGATCAAGACCCTGAAGA	0.502000													7	19					0	0	1	0	0
CACNA1G	8913	broad.mit.edu	37	17	48696036	48696036	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:48696036C>T	ENST00000352832.5	+	31	5718	c.5346C>T	c.(5344-5346)gaC>gaT	p.D1782D	CACNA1G_ENST00000505165.1_Silent_p.D1816D|CACNA1G_ENST00000515411.1_Silent_p.D1798D|CACNA1G_ENST00000442258.2_Silent_p.D1775D|CACNA1G_ENST00000502264.1_Silent_p.D1793D|CACNA1G_ENST00000515165.1_Silent_p.D1816D|CACNA1G_ENST00000354983.4_Silent_p.D1782D|CACNA1G_ENST00000510115.1_Silent_p.D1782D|CACNA1G_ENST00000359106.5_Silent_p.D1816D|CACNA1G_ENST00000515765.1_Silent_p.D1805D|CACNA1G_ENST00000360761.4_Silent_p.D1793D|CACNA1G_ENST00000513964.1_Silent_p.D1771D|CACNA1G_ENST00000507609.1_Silent_p.D1809D|CACNA1G_ENST00000513689.2_Silent_p.D1771D|CACNA1G_ENST00000503485.1_Silent_p.D1782D|CACNA1G_ENST00000507896.1_Silent_p.D1805D|CACNA1G_ENST00000429973.2_Silent_p.D1798D|CACNA1G_ENST00000358244.5_Silent_p.D1782D|CACNA1G_ENST00000510366.1_Silent_p.D1764D|CACNA1G_ENST00000507510.2_Silent_p.D1816D|CACNA1G_ENST00000507336.1_Silent_p.D1805D|CACNA1G_ENST00000514717.1_Silent_p.D1759D|CACNA1G_ENST00000512389.1_Silent_p.D1805D|CACNA1G_ENST00000514181.1_Silent_p.D1791D|CACNA1G_ENST00000514079.1_Silent_p.D1823D	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	1816					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GGGACTGTGACCAGGAGTCCA	0.577000													4	27					0	0	1	0	0
WDPCP	51057	broad.mit.edu	37	2	63349172	63349172	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:63349172G>A	ENST00000409120.1	-	12	5184	c.1634C>T	c.(1633-1635)tCt>tTt	p.S545F	WDPCP_ENST00000398544.3_Missense_Mutation_p.S578F|WDPCP_ENST00000409199.1_Missense_Mutation_p.S545F|WDPCP_ENST00000272321.7_Missense_Mutation_p.S737F			O95876	FRITZ_HUMAN	WD repeat containing planar cell polarity effector	737					cilium morphogenesis|regulation of embryonic cell shape|regulation of protein localization|septin cytoskeleton organization	cilium axoneme|cytoplasm|cytoskeleton|plasma membrane				central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(19)|ovary(1)|skin(1)	35						CATTTTGAGAGAACCACCATC	0.279000													15	59					0	0	1	0	0
TBC1D8	11138	broad.mit.edu	37	2	101656805	101656805	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:101656805G>A	ENST00000409318.1	-	6	1045	c.915C>T	c.(913-915)ttC>ttT	p.F305F	TBC1D8_ENST00000376840.4_Silent_p.F290F	NM_001102426.1	NP_001095896.1	O95759	TBCD8_HUMAN	TBC1 domain family, member 8 (with GRAM domain)	290	GRAM 2.				blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			breast(1)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(2)|lung(12)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	32						GCAACCTGAAGAAAGCCCGGA	0.572000													6	16					0	0	1	0	0
ABCB1	5243	broad.mit.edu	37	7	87196174	87196174	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr7:87196174G>A	ENST00000265724.3	-	7	874	c.457C>T	c.(457-459)Cat>Tat	p.H153Y	ABCB1_ENST00000543898.1_Intron	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	153	ABC transmembrane type-1 1.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	ATTATAGCATGAAAAAACTGT	0.418000													9	41					0	0	1	0	0
FGD3	89846	broad.mit.edu	37	9	95784614	95784614	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:95784614G>A	ENST00000375482.3	+	14	1996	c.1500G>A	c.(1498-1500)acG>acA	p.T500T	FGD3_ENST00000416701.2_Silent_p.T500T|FGD3_ENST00000337352.6_Silent_p.T500T|FGD3_ENST00000538555.1_Silent_p.T103T	NM_001083536.1	NP_001077005.1	Q5JSP0	FGD3_HUMAN	FYVE, RhoGEF and PH domain containing 3	500					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|urinary_tract(1)	17						TCTAGATCACGAGCACCAGCC	0.637000													16	40					0	0	1	0	0
KIF23	9493	broad.mit.edu	37	15	69721528	69721528	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:69721528G>A	ENST00000260363.4	+	10	1165	c.1048G>A	c.(1048-1050)Gaa>Aaa	p.E350K	KIF23_ENST00000537891.1_Missense_Mutation_p.E167K|KIF23_ENST00000395392.2_Missense_Mutation_p.E350K|KIF23_ENST00000559279.1_Missense_Mutation_p.E350K|KIF23_ENST00000352331.4_Missense_Mutation_p.E350K|KIF23_ENST00000558585.1_Missense_Mutation_p.E167K	NM_138555.2	NP_612565.1	Q02241	KIF23_HUMAN	kinesin family member 23	350	Kinesin-motor.				blood coagulation|cytokinesis|microtubule-based movement|mitosis|mitotic spindle elongation	cytosol|kinesin complex|microtubule|midbody|nucleoplasm|spindle	ATP binding|microtubule motor activity|protein binding			central_nervous_system(1)|endometrium(4)|large_intestine(7)|lung(6)|prostate(2)|skin(1)	21						GACCAGAGCAGAAGGGAACAG	0.368000													13	16					0	0	1	0	0
ADAMTSL5	339366	broad.mit.edu	37	19	1508069	1508069	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:1508069C>T	ENST00000330475.4	-	7	972	c.529G>A	c.(529-531)Gag>Aag	p.E177K	ADAMTSL5_ENST00000413997.2_Missense_Mutation_p.E187K|ADAMTSL5_ENST00000395467.2_5'UTR|ADAMTSL5_ENST00000590562.1_5'UTR	NM_213604.2	NP_998769.2	Q6ZMM2	ATL5_HUMAN	ADAMTS-like 5	177						proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			cervix(1)|kidney(1)|large_intestine(2)|lung(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	10		Acute lymphoblastic leukemia(61;5.61e-13)|all_hematologic(61;2.65e-08)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGCGGTCCTCGAGGGCACCC	0.682000													6	11					0	0	1	0	0
MTRR	4552	broad.mit.edu	37	5	7878257	7878257	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:7878257G>A	ENST00000264668.2	+	5	713	c.683G>A	c.(682-684)aGa>aAa	p.R228K	MTRR_ENST00000440940.2_Missense_Mutation_p.R201K|MTRR_ENST00000341013.6_3'UTR	NM_002454.2|NM_024010.2	NP_002445.2|NP_076915.2	Q9UBK8	MTRR_HUMAN	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	228	Hinge.				methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			NS(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(14)|ovary(1)|prostate(3)|stomach(1)	31					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	GATTCAGGAAGAAAGGATTCT	0.468000													9	177					0	0	1	0	0
ITIH4	3700	broad.mit.edu	37	3	52858879	52858879	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:52858879C>T	ENST00000266041.4	-	7	951	c.855G>A	c.(853-855)atG>atA	p.M285I	ITIH4_ENST00000406595.1_Missense_Mutation_p.M285I|ITIH4_ENST00000346281.5_Missense_Mutation_p.M285I|ITIH4-AS1_ENST00000478366.1_RNA|ITIH4_ENST00000485816.1_Missense_Mutation_p.M285I|ITIH4_ENST00000434759.3_Missense_Mutation_p.M197I|RP5-966M1.6_ENST00000468472.1_3'UTR	NM_002218.4	NP_002209.2	Q14624	ITIH4_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 4	285	VWFA.				acute-phase response|hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(9)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		TCCTGCCACTCATGGAGCCGC	0.572000													37	71					0	0	1	0	0
RPA1	6117	broad.mit.edu	37	17	1780584	1780584	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:1780584C>T	ENST00000254719.5	+	8	776	c.666C>T	c.(664-666)ttC>ttT	p.F222F	RPA1_ENST00000573924.1_3'UTR	NM_002945.3	NP_002936.1	P27694	RFA1_HUMAN	replication protein A1, 70kDa	222					cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	actin cytoskeleton|cytoplasm|DNA replication factor A complex|PML body	metal ion binding|protein binding|single-stranded DNA binding			breast(1)|endometrium(3)|large_intestine(2)|lung(2)|ovary(2)	10						GGAAGCTTTTCTCCCTAGAAC	0.532000								Nucleotide excision repair (NER)					7	22					0	0	1	0	0
TXNIP	10628	broad.mit.edu	37	1	145439622	145439622	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:145439622G>A	ENST00000369317.4	+	2	614	c.280G>A	c.(280-282)Gga>Aga	p.G94R	TXNIP_ENST00000475171.1_Intron	NM_006472.3	NP_006463.3	Q9H3M7	TXNIP_HUMAN	thioredoxin interacting protein	94					cell cycle|keratinocyte differentiation|transcription, DNA-dependent		ubiquitin protein ligase binding			breast(3)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(1)|lung(5)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	21	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CATGAGACCTGGAAACAAATA	0.398000													33	122					0	0	1	0	0
ROR2	4920	broad.mit.edu	37	9	94493358	94493358	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:94493358C>T	ENST00000375708.3	-	7	1215	c.1017G>A	c.(1015-1017)ccG>ccA	p.P339P	ROR2_ENST00000550066.1_5'UTR|ROR2_ENST00000375715.1_Silent_p.P199P	NM_004560.3	NP_004551.2	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	339	Kringle.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						GCAGGGCCCACGGCTGGCACT	0.612000													33	51					0	0	1	0	0
KLHL40	131377	broad.mit.edu	37	3	42727254	42727254	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:42727254C>T	ENST00000287777.4	+	1	244	c.144C>T	c.(142-144)cgC>cgT	p.R48R		NM_152393.2	NP_689606.2			kelch-like family member 40																		CGTGCCATCGCCTGGTGCTGG	0.692000													7	28					0	0	1	0	0
MAML2	84441	broad.mit.edu	37	11	96074933	96074933	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:96074933G>C	ENST00000524717.1	-	1	1411	c.127C>G	c.(127-129)Cgg>Ggg	p.R43G		NM_032427.1	NP_115803.1	Q8IZL2	MAML2_HUMAN	mastermind-like 2 (Drosophila)	43					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC3/MAML2(26)|CRTC1/MAML2(516)	breast(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	43		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				ACAGCGATCCGAGCCCGGAGG	0.657000			T	"""MECT1, CRTC3"""	salivary gland mucoepidermoid						OREG0021305	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	9					0	0	1	0	0
ZNF445	353274	broad.mit.edu	37	3	44497005	44497005	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:44497005G>C	ENST00000425708.2	-	2	378	c.37C>G	c.(37-39)Cag>Gag	p.Q13E	ZNF445_ENST00000396077.2_Missense_Mutation_p.Q13E			P59923	ZN445_HUMAN	zinc finger protein 445	13					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(8)|ovary(2)|pancreas(1)|skin(3)	31				KIRC - Kidney renal clear cell carcinoma(197;0.0514)|Kidney(197;0.0646)		GACTGGGCCTGAGCTGGATAG	0.567000													5	44					0	0	1	0	0
SBNO1	55206	broad.mit.edu	37	12	123789171	123789171	+	Silent	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:123789171G>C	ENST00000420886.2	-	28	3725	c.3726C>G	c.(3724-3726)ctC>ctG	p.L1242L	SBNO1_ENST00000602398.1_Silent_p.L1242L|SBNO1_ENST00000602750.1_Silent_p.L1241L|SBNO1_ENST00000267176.4_Silent_p.L1241L	NM_001167856.1	NP_001161328.1	A3KN83	SBNO1_HUMAN	strawberry notch homolog 1 (Drosophila)	1242							ATP binding|DNA binding|hydrolase activity			NS(2)|breast(6)|cervix(2)|endometrium(8)|kidney(3)|large_intestine(11)|lung(18)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(2)	62	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		TTTCTAATTTGAGCTGCTTCC	0.299000													7	20					0	0	1	0	0
RC3H1	149041	broad.mit.edu	37	1	173952637	173952637	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:173952637G>C	ENST00000367696.2	-	4	862	c.511C>G	c.(511-513)Ctc>Gtc	p.L171V	RC3H1_ENST00000258349.4_Missense_Mutation_p.L171V|RC3H1_ENST00000367694.2_Missense_Mutation_p.L171V			Q5TC82	RC3H1_HUMAN	ring finger and CCCH-type domains 1	171					cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	50						TGGTGCTGGAGAATGAGCTCT	0.483000													20	85					0	0	1	0	0
STMN3	50861	broad.mit.edu	37	20	62275132	62275132	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:62275132C>G	ENST00000370053.1	-	3	349	c.268G>C	c.(268-270)Gag>Cag	p.E90Q	STMN3_ENST00000540534.1_Missense_Mutation_p.E79Q	NM_001276310.1|NM_015894.2	NP_001263239.1|NP_056978.2	Q9NZ72	STMN3_HUMAN	stathmin-like 3	90					cytoplasmic microtubule organization|intracellular signal transduction|negative regulation of Rac protein signal transduction|neuron projection development|regulation of cytoskeleton organization|regulation of Rac GTPase activity	cytoplasm	protein domain specific binding			kidney(1)|large_intestine(1)|lung(5)|prostate(1)	8	all_cancers(38;2.31e-11)|all_epithelial(29;7.76e-13)		Epithelial(9;1.9e-09)|all cancers(9;1.22e-08)|BRCA - Breast invasive adenocarcinoma(10;8.86e-06)|OV - Ovarian serous cystadenocarcinoma(5;0.00559)			TCGGCTGCCTCCAGCCGCTTT	0.642000													13	36					0	0	1	0	0
PTH2R	5746	broad.mit.edu	37	2	209307167	209307167	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:209307167C>G	ENST00000272847.2	+	5	703	c.490C>G	c.(490-492)Ctc>Gtc	p.L164V	PTH2R_ENST00000413482.1_3'UTR	NM_005048.2	NP_005039.1	P49190	PTH2R_HUMAN	parathyroid hormone 2 receptor	164						integral to plasma membrane	parathyroid hormone receptor activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(21)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	43				Epithelial(149;0.0684)|Lung(261;0.0785)|LUSC - Lung squamous cell carcinoma(261;0.0836)		TGTGGCTATTCTCATCATTGG	0.438000													34	82					0	0	1	0	0
SNRPB2	6629	broad.mit.edu	37	20	16719545	16719545	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:16719545C>A	ENST00000246071.6	+	5	643	c.427C>A	c.(427-429)Cag>Aag	p.Q143K	SNRPB2_ENST00000377943.5_Missense_Mutation_p.Q143K	NM_003092.4	NP_003083.1	P08579	RU2B_HUMAN	small nuclear ribonucleoprotein polypeptide B	143						catalytic step 2 spliceosome|nucleoplasm|U2 snRNP	nucleotide binding|protein binding|RNA binding			large_intestine(2)|lung(2)|urinary_tract(1)	5						ACCAAATCCTCAGGTAATTTT	0.328000													6	16					2.0095e-06	2.05697e-06	1	1	0
BRINP1	1620	broad.mit.edu	37	9	121929416	121929416	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:121929416C>T	ENST00000265922.3	-	8	2693	c.2232G>A	c.(2230-2232)ctG>ctA	p.L744L	BRINP1_ENST00000482797.1_Intron	NM_014618.2	NP_055433.2			bone morphogenetic protein/retinoic acid inducible neural-specific 1	744																	CCGTGTTGTACAGGTCCAAGG	0.537000													28	127					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141724872	141724872	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr7:141724872C>T	ENST00000475668.2	+	8	959	c.905C>T	c.(904-906)gCg>gTg	p.A302V	MGAM_ENST00000549489.2_Missense_Mutation_p.A302V			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	302	Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	TTGTATGGTGCGCAGACATTC	0.398000													17	26					0	0	1	0	0
PARP4	143	broad.mit.edu	37	13	25016097	25016097	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr13:25016097C>G	ENST00000381989.3	-	30	3658	c.3553G>C	c.(3553-3555)Gag>Cag	p.E1185Q		NM_006437.3	NP_006428.2	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	1185					cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(14)|lung(18)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	63		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		AAAGGCGACTCATTCTCATCC	0.403000													11	42					0	0	1	0	0
SERBP1	26135	broad.mit.edu	37	1	67890585	67890585	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:67890585G>A	ENST00000370994.4	-	4	777	c.663C>T	c.(661-663)gtC>gtT	p.V221V	SERBP1_ENST00000484880.1_5'UTR|SERBP1_ENST00000361219.6_Silent_p.V227V|SERBP1_ENST00000370995.2_Silent_p.V227V|SERBP1_ENST00000370990.5_Silent_p.V221V	NM_001018067.1|NM_001018068.1|NM_001018069.1|NM_015640.3	NP_001018077.1|NP_001018078.1|NP_001018079.1|NP_056455.3	Q8NC51	PAIRB_HUMAN	SERPINE1 mRNA binding protein 1	227					regulation of mRNA stability	nucleus|perinuclear region of cytoplasm	mRNA 3'-UTR binding|protein binding			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|skin(1)|upper_aerodigestive_tract(2)	13						ATTCGTCTTTGACAGTTCCCC	0.368000													34	59					0	0	1	0	0
OR2M5	127059	broad.mit.edu	37	1	248308805	248308805	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:248308805C>G	ENST00000366476.1	+	1	356	c.356C>G	c.(355-357)tCt>tGt	p.S119C		NM_001004690.1	NP_001004690.1	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M, member 5	119					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(7)|liver(1)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	49	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			GCTGTTATGTCTTATGACCGC	0.453000													116	354					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7579529	7579529	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:7579529C>T	ENST00000420246.2	-	4	290	c.158G>A	c.(157-159)tGg>tAg	p.W53*	TP53_ENST00000445888.2_Nonsense_Mutation_p.W53*|TP53_ENST00000413465.2_Nonsense_Mutation_p.W53*|TP53_ENST00000269305.4_Nonsense_Mutation_p.W53*|TP53_ENST00000455263.2_Nonsense_Mutation_p.W53*|TP53_ENST00000359597.4_Nonsense_Mutation_p.W53*	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	53	Interaction with HRMT1L2.		W -> C (in sporadic cancers; somatic mutation).|W -> G (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.W53*(4)|p.E51fs*59(1)|p.D48fs*55(1)|p.Q52fs*67(1)|p.P13fs*18(1)|p.S33fs*23(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTCAGTGAACCATTGTTCAAT	0.592000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			49	128					0	0	1	0	0
MAML2	84441	broad.mit.edu	37	11	96074994	96074994	+	Silent	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:96074994G>C	ENST00000524717.1	-	1	1350	c.66C>G	c.(64-66)ctC>ctG	p.L22L		NM_032427.1	NP_115803.1	Q8IZL2	MAML2_HUMAN	mastermind-like 2 (Drosophila)	22					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC3/MAML2(26)|CRTC1/MAML2(516)	breast(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	43		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				CCCCTCCAAGGAGCCCCGCCC	0.682000			T	"""MECT1, CRTC3"""	salivary gland mucoepidermoid						OREG0021305	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	3					0	0	1	0	0
FAT2	2196	broad.mit.edu	37	5	150924410	150924410	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:150924410G>T	ENST00000261800.5	-	9	6290	c.6278C>A	c.(6277-6279)tCt>tAt	p.S2093Y		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	2093	Cadherin 18.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATCAGTGGCAGATACCTGAAA	0.443000													36	100					8.16277e-20	8.59239e-20	1	1	0
EML3	256364	broad.mit.edu	37	11	62378910	62378910	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:62378910G>A	ENST00000394773.2	-	2	488	c.181C>T	c.(181-183)Cct>Tct	p.P61S	EML3_ENST00000529309.1_Missense_Mutation_p.P61S|EML3_ENST00000278845.4_Missense_Mutation_p.P61S|EML3_ENST00000494176.2_Missense_Mutation_p.P32S	NM_153265.2	NP_694997.2	Q32P44	EMAL3_HUMAN	echinoderm microtubule associated protein like 3	61						cytoplasm|microtubule	protein binding			biliary_tract(1)|breast(3)|endometrium(4)|kidney(2)|large_intestine(1)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26						TCCCCCGGAGGAGCTGGTGTG	0.602000													8	30					0	0	1	0	0
PXDC1	221749	broad.mit.edu	37	6	3723966	3723966	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:3723966C>G	ENST00000380283.4	-	5	1077	c.583G>C	c.(583-585)Gag>Cag	p.E195Q	PXDC1_ENST00000477592.2_5'UTR	NM_183373.3	NP_899229.2	Q5TGL8	CF145_HUMAN	PX domain containing 1	195					cell communication		phosphatidylinositol binding										CTGCCATTCTCAAATCTGAAA	0.537000													16	41					0	0	1	0	0
KLHL18	23276	broad.mit.edu	37	3	47385224	47385224	+	Silent	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:47385224G>C	ENST00000232766.5	+	10	1538	c.1518G>C	c.(1516-1518)ctG>ctC	p.L506L	KLHL18_ENST00000455924.2_Silent_p.L394L	NM_025010.4	NP_079286.2	O94889	KLH18_HUMAN	kelch-like family member 18	506										endometrium(2)|kidney(1)|large_intestine(7)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	21		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00645)|Kidney(197;0.00741)		AGTGGTGCCTGATTGTCCCCA	0.622000													21	70					0	0	1	0	0
ESPL1	9700	broad.mit.edu	37	12	53677939	53677939	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:53677939G>C	ENST00000257934.4	+	17	3266	c.3175G>C	c.(3175-3177)Gag>Cag	p.E1059Q	ESPL1_ENST00000552462.1_Missense_Mutation_p.E1059Q	NM_012291.4	NP_036423.4	Q14674	ESPL1_HUMAN	extra spindle pole bodies homolog 1 (S. cerevisiae)	1059					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(10)|large_intestine(12)|lung(21)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(8)	70						GTTCTTGCTTGAGTCTTGCAC	0.527000													32	52					0	0	1	0	0
MTX1	4580	broad.mit.edu	37	1	155181948	155181948	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:155181948C>T	ENST00000368376.3	+	4	815	c.709C>T	c.(709-711)Cgg>Tgg	p.R237W	MTX1_ENST00000316721.4_Intron|MTX1_ENST00000609421.1_Missense_Mutation_p.R88W|RP11-263K19.6_ENST00000455788.1_RNA|MTX1_ENST00000495589.1_3'UTR	NM_002455.3	NP_002446.2	Q13505	MTX1_HUMAN	metaxin 1	237					protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane	protein binding			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|prostate(1)|skin(1)	7	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			TCTGTCAGCTCGGCAAGGGGC	0.577000													7	80					0	0	1	0	0
GON4L	54856	broad.mit.edu	37	1	155784175	155784175	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:155784175C>G	ENST00000437809.1	-	9	1349	c.1227G>C	c.(1225-1227)ttG>ttC	p.L409F	GON4L_ENST00000471341.1_5'UTR|GON4L_ENST00000271883.5_Missense_Mutation_p.L409F|GON4L_ENST00000368331.1_Missense_Mutation_p.L409F|GON4L_ENST00000361040.5_Missense_Mutation_p.L409F	NM_001282856.1	NP_001269785.1	Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	409					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					AAGACTGCCTCAATCTGGATT	0.393000													24	107					0	0	1	0	0
FUT8	2530	broad.mit.edu	37	14	66209049	66209049	+	Missense_Mutation	SNP	C	C	T	rs149328619	byFrequency	TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr14:66209049C>T	ENST00000360689.5	+	11	3376	c.1649C>T	c.(1648-1650)aCg>aTg	p.T550M	FUT8_ENST00000557164.1_Missense_Mutation_p.T387M|FUT8_ENST00000394585.1_Missense_Mutation_p.T550M|FUT8_ENST00000358307.2_Missense_Mutation_p.T421M|FUT8_ENST00000394586.2_Missense_Mutation_p.T550M|FUT8_ENST00000417683.1_Missense_Mutation_p.T144M	NM_004480.4|NM_178155.2	NP_004471.4|NP_835368.1	Q9BYC5	FUT8_HUMAN	fucosyltransferase 8 (alpha (1,6) fucosyltransferase)	550	SH3.				in utero embryonic development|L-fucose catabolic process|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in Golgi|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	glycoprotein 6-alpha-L-fucosyltransferase activity|SH3 domain binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)	22				all cancers(60;0.00109)|OV - Ovarian serous cystadenocarcinoma(108;0.00242)|BRCA - Breast invasive adenocarcinoma(234;0.0114)		TTGGGAAGGACGGGCCTATAT	0.443000													15	79					0	0	1	0	0
BBS4	585	broad.mit.edu	37	15	73004593	73004593	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:73004593C>G	ENST00000268057.4	+	4	206	c.165C>G	c.(163-165)atC>atG	p.I55M	BBS4_ENST00000542334.1_5'UTR|BBS4_ENST00000564239.1_3'UTR|BBS4_ENST00000539603.1_Missense_Mutation_p.I43M|BBS4_ENST00000395205.2_Missense_Mutation_p.I63M	NM_033028.4	NP_149017.2	Q96RK4	BBS4_HUMAN	Bardet-Biedl syndrome 4	55	Required for localization to centrosomes.				adult behavior|brain morphogenesis|cell cycle cytokinesis|centrosome organization|cerebral cortex development|convergent extension involved in gastrulation|dendrite development|fat cell differentiation|heart looping|hippocampus development|intracellular transport|maintenance of protein location in nucleus|melanosome transport|microtubule anchoring at centrosome|neural tube closure|nonmotile primary cilium assembly|photoreceptor cell maintenance|pigment granule aggregation in cell center|positive regulation of flagellum assembly|regulation of cilium beat frequency involved in ciliary motility|regulation of cytokinesis|regulation of lipid metabolic process|retina homeostasis|retinal rod cell development|sensory perception of smell|sensory processing|spermatid development|striatum development	BBSome|centriolar satellite|centriole|cilium membrane|microtubule basal body|motile cilium|nonmotile primary cilium|nucleus|pericentriolar material	alpha-tubulin binding|beta-tubulin binding|dynactin binding|microtubule motor activity			autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|prostate(2)|urinary_tract(1)	19						AGGCTGTTATCAAAGAACAGC	0.418000									Bardet-Biedl syndrome				6	25					0	0	1	0	0
TDRD9	122402	broad.mit.edu	37	14	104488586	104488586	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr14:104488586C>T	ENST00000409874.4	+	24	2573	c.2525C>T	c.(2524-2526)tCa>tTa	p.S842L	TDRD9_ENST00000339063.5_Missense_Mutation_p.S842L	NM_153046.2	NP_694591.2	Q8NDG6	TDRD9_HUMAN	tudor domain containing 9	842					cell differentiation|DNA methylation involved in gamete generation|fertilization|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	nucleus|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	33		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0768)				CTAAAAGTTTCACTTGAACTC	0.428000													6	16					0	0	1	0	0
HSD3B2	3284	broad.mit.edu	37	1	119962079	119962079	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:119962079G>C	ENST00000543831.1	+	3	430	c.181G>C	c.(181-183)Gac>Cac	p.D61H	HSD3B2_ENST00000471656.1_3'UTR|HSD3B2_ENST00000369416.3_Missense_Mutation_p.D61H	NM_001166120.1	NP_001159592.1	P26439	3BHS2_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	61					androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(19)|ovary(2)|skin(1)	27	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	ACTTGAAGGAGACATTCTGGA	0.493000													11	35					0	0	1	0	0
ZNF462	58499	broad.mit.edu	37	9	109690177	109690177	+	Silent	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:109690177C>G	ENST00000277225.5	+	3	4273	c.3984C>G	c.(3982-3984)ctC>ctG	p.L1328L	ZNF462_ENST00000457913.1_Silent_p.L1328L|ZNF462_ENST00000441147.2_Silent_p.L173L			Q96JM2	ZN462_HUMAN	zinc finger protein 462	1328					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						ACGGTTTGCTCCTGCATTACC	0.527000													33	105					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78314035	78314035	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:78314035C>T	ENST00000582970.1	+	26	6011	c.5868C>T	c.(5866-5868)ctC>ctT	p.L1956L	RNF213_ENST00000508628.2_Silent_p.L2005L|RNF213_ENST00000336301.6_Silent_p.L29L	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			AGGCACCCCTCGAGGCCATCC	0.632000													11	33					0	0	1	0	0
SPATA9	83890	broad.mit.edu	37	5	95011140	95011140	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:95011140C>T	ENST00000274432.8	-	3	495	c.354G>A	c.(352-354)ccG>ccA	p.P118P	RFESD_ENST00000508206.1_Intron|SPATA9_ENST00000395899.3_Silent_p.P118P|SPATA9_ENST00000477047.2_5'UTR	NM_031952.3	NP_114158.2	Q9BWV2	SPAT9_HUMAN	spermatogenesis associated 9	118					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				large_intestine(3)|lung(4)	7		all_cancers(142;1.28e-06)|all_epithelial(76;1.55e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)|Colorectal(57;0.0846)|Breast(839;0.198)		all cancers(79;8.91e-16)		GGGGTTGCCTCGGCGCATTAA	0.408000													20	40					0	0	1	0	0
CCDC88C	440193	broad.mit.edu	37	14	91805717	91805717	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr14:91805717G>A	ENST00000389857.6	-	8	800	c.714C>T	c.(712-714)ccC>ccT	p.P238P		NM_001080414.3	NP_001073883.2	Q9P219	DAPLE_HUMAN	coiled-coil domain containing 88C	238					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(6)|pancreas(1)|urinary_tract(1)	24		all_cancers(154;0.0468)				TGGTGGGGCTGGGAGTGGAGT	0.662000													4	18					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6678241	6678241	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:6678241C>T	ENST00000245907.6	-	40	4864	c.4772G>A	c.(4771-4773)aGa>aAa	p.R1591K	C3_ENST00000599668.1_5'UTR	NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	1591	NTR.				complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		CAGGGCTTCTCTGCACTTGAT	0.587000													16	31					0	0	1	0	0
ZFYVE16	9765	broad.mit.edu	37	5	79734015	79734015	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:79734015C>G	ENST00000338008.5	+	3	1691	c.1511C>G	c.(1510-1512)tCa>tGa	p.S504*	ZFYVE16_ENST00000505560.1_Nonsense_Mutation_p.S504*|ZFYVE16_ENST00000510158.1_Nonsense_Mutation_p.S504*	NM_001284236.1|NM_014733.3	NP_001271165.1|NP_055548	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16	504					BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity			breast(4)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(14)|liver(1)|lung(6)|ovary(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)		AATACTTTTTCAAGCAATGAT	0.403000													26	53					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77375607	77375607	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr16:77375607C>G	ENST00000282849.5	-	11	2122	c.1704G>C	c.(1702-1704)ttG>ttC	p.L568F		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	568	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						TTACCATACTCAAGCCACAAA	0.418000													6	17					0	0	1	0	0
FLYWCH1	84256	broad.mit.edu	37	16	2983500	2983500	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr16:2983500G>A	ENST00000399667.2	+	5	1529	c.1166G>A	c.(1165-1167)aGa>aAa	p.R389K	FLYWCH1_ENST00000416288.2_Missense_Mutation_p.R388K|FLYWCH1_ENST00000253928.9_Missense_Mutation_p.R389K			Q4VC44	FWCH1_HUMAN	FLYWCH-type zinc finger 1	389						nucleus	DNA binding|metal ion binding			kidney(1)|lung(3)	4						CCTCGGCCCAGAAAGCGAGCA	0.657000													5	8					0	0	1	0	0
ADRM1	11047	broad.mit.edu	37	20	60878723	60878723	+	Silent	SNP	G	G	A	rs144780505		TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:60878723G>A	ENST00000253003.2	+	2	145	c.99G>A	c.(97-99)ctG>ctA	p.L33L	ADRM1_ENST00000462554.1_3'UTR	NM_007002.2|NM_175573.1	NP_008933.2|NP_783163.1	Q16186	ADRM1_HUMAN	adhesion regulating molecule 1	33	Interaction with PSMD1.|PH.				proteasome assembly|transcription elongation from RNA polymerase II promoter	cytoplasm|integral to plasma membrane|membrane fraction|nucleus|proteasome complex	endopeptidase activator activity|protease binding|proteasome binding			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|urinary_tract(1)	5	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;2.51e-06)			AGATGTCCCTGAAGGGGACCA	0.597000													40	82					0	0	1	0	0
EPB41L5	57669	broad.mit.edu	37	2	120844814	120844814	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:120844814C>G	ENST00000263713.5	+	11	1085	c.871C>G	c.(871-873)Cag>Gag	p.Q291E	EPB41L5_ENST00000452780.1_Missense_Mutation_p.Q291E|EPB41L5_ENST00000443124.1_Missense_Mutation_p.Q291E|EPB41L5_ENST00000331393.4_Missense_Mutation_p.Q291E|EPB41L5_ENST00000443902.2_Missense_Mutation_p.Q291E	NM_020909.3	NP_065960.2	Q9HCM4	E41L5_HUMAN	erythrocyte membrane protein band 4.1 like 5	291	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(5)|lung(12)|ovary(1)	26						AGATGATGATCAGGTAGGAAT	0.294000													9	50					0	0	1	0	0
ZFYVE16	9765	broad.mit.edu	37	5	79733262	79733262	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:79733262C>A	ENST00000338008.5	+	3	938	c.758C>A	c.(757-759)tCc>tAc	p.S253Y	ZFYVE16_ENST00000505560.1_Missense_Mutation_p.S253Y|ZFYVE16_ENST00000510158.1_Missense_Mutation_p.S253Y	NM_001284236.1|NM_014733.3	NP_001271165.1|NP_055548	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16	253					BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity			breast(4)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(14)|liver(1)|lung(6)|ovary(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)		CGACAAAGTTCCAAAATGTTT	0.343000													26	67					2.27525e-19	2.39017e-19	1	1	0
KDM4C	23081	broad.mit.edu	37	9	7174705	7174705	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:7174705G>A	ENST00000381309.3	+	22	3712	c.3147G>A	c.(3145-3147)caG>caA	p.Q1049Q	KDM4C_ENST00000428870.2_Silent_p.Q736Q|KDM4C_ENST00000442236.2_Silent_p.Q794Q	NM_015061.3	NP_055876.2	Q9H3R0	KDM4C_HUMAN	lysine (K)-specific demethylase 4C	1049					positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	nuclear chromatin	androgen receptor binding|enzyme binding|histone demethylase activity (H3-K9 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(8)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	43						GCTCTTTCCAGAAGAAGTGCC	0.498000													43	114					0	0	1	0	0
THEMIS	387357	broad.mit.edu	37	6	128222209	128222209	+	Translation_Start_Site	SNP	G	G	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:128222209G>T	ENST00000368250.1	-	0	130				THEMIS_ENST00000368248.2_De_novo_Start_InFrame|THEMIS_ENST00000537166.1_Intron|THEMIS_ENST00000543064.1_De_novo_Start_InFrame			Q8N1K5	THMS1_HUMAN	thymocyte selection associated						negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(3)	60						ACTACAGCCAGAGTGGGGTGG	0.507000													3	18					0.004672	0.00469911	1	1	0
ZNF613	79898	broad.mit.edu	37	19	52448420	52448420	+	Silent	SNP	T	T	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:52448420T>C	ENST00000293471.6	+	6	1963	c.1284T>C	c.(1282-1284)taT>taC	p.Y428Y	ZNF613_ENST00000391794.4_Silent_p.Y392Y|ZNF613_ENST00000601794.1_3'UTR	NM_001031721.3	NP_001026891.2	Q6PF04	ZN613_HUMAN	zinc finger protein 613	428					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	19		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.0183)		AGAAACCCTATGTATGCAATG	0.423000													30	32					0	0	1	0	0
C11orf24	53838	broad.mit.edu	37	11	68029775	68029775	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:68029775G>A	ENST00000304271.6	-	4	1090	c.688C>T	c.(688-690)Cgt>Tgt	p.R230C	C11orf24_ENST00000533310.1_Intron	NM_022338.3	NP_071733.1	Q96F05	CK024_HUMAN	chromosome 11 open reading frame 24	230	Pro-rich.					integral to membrane				endometrium(3)|kidney(3)|large_intestine(3)|lung(3)|ovary(1)	13						GGACTTGGACGAGTGCTCATG	0.587000													20	60					0	0	1	0	0
DMRT3	58524	broad.mit.edu	37	9	990293	990293	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:990293C>T	ENST00000190165.2	+	2	745	c.707C>T	c.(706-708)tCg>tTg	p.S236L		NM_021240.2	NP_067063.1	Q9NQL9	DMRT3_HUMAN	doublesex and mab-3 related transcription factor 3	236					cell differentiation|multicellular organismal development|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	26		all_lung(10;1.39e-08)|Lung NSC(10;1.42e-08)		Lung(218;0.0196)		GAGGGCCCCTCGGGGACTGTT	0.572000													18	46					0	0	1	0	0
ZNF197	10168	broad.mit.edu	37	3	44683588	44683588	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:44683588G>A	ENST00000396058.1	+	5	1133	c.966G>A	c.(964-966)aaG>aaA	p.K322K	RP11-944L7.4_ENST00000457331.1_RNA|ZNF197_ENST00000344387.4_Silent_p.K322K|ZNF197_ENST00000383744.4_Intron|ZNF197_ENST00000383745.2_Intron			O14709	ZN197_HUMAN	zinc finger protein 197	322					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|skin(1)	25				KIRC - Kidney renal clear cell carcinoma(197;0.0478)|Kidney(197;0.0598)		ATACAGTGAAGAAAGTTTCCC	0.443000													21	43					0	0	1	0	0
KRT15	3866	broad.mit.edu	37	17	39673157	39673157	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:39673157C>T	ENST00000254043.3	-	3	4226	c.641G>A	c.(640-642)cGa>cAa	p.R214Q	KRT15_ENST00000393974.3_Missense_Mutation_p.R49Q|KRT15_ENST00000393981.3_Missense_Mutation_p.R49Q|KRT15_ENST00000393976.2_Missense_Mutation_p.R214Q	NM_002275.3	NP_002266	P19012	K1C15_HUMAN	keratin 15	214	Coil 1B.|Rod.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16		Breast(137;0.000286)				ATCCAGGACTCGGCGCAAGCC	0.592000													31	60					0	0	1	0	0
ZSCAN31	64288	broad.mit.edu	37	6	28295307	28295307	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:28295307G>A	ENST00000414429.1	-	7	1288	c.385C>T	c.(385-387)Cca>Tca	p.P129S	ZSCAN31_ENST00000439158.1_Missense_Mutation_p.P129S|ZSCAN31_ENST00000446474.1_5'UTR|ZSCAN31_ENST00000344279.6_Missense_Mutation_p.P129S|ZSCAN31_ENST00000396838.2_Missense_Mutation_p.P129S					zinc finger and SCAN domain containing 31																		TCATGGTCTGGAGCCTGAAGG	0.423000													23	66					0	0	1	0	0
NUPL1	9818	broad.mit.edu	37	13	25876015	25876015	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr13:25876015C>T	ENST00000463407.1	+	1	247	c.104C>T	c.(103-105)tCt>tTt	p.S35F	NUPL1_ENST00000381718.3_Missense_Mutation_p.S35F|NUPL1_ENST00000466694.1_3'UTR|NUPL1_ENST00000381736.3_Missense_Mutation_p.S35F			Q9BVL2	NUPL1_HUMAN	nucleoporin like 1	35	14 X 2 AA repeats of F-G.				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore				breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|stomach(1)|urinary_tract(1)	16		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.0092)|Epithelial(112;0.0477)|OV - Ovarian serous cystadenocarcinoma(117;0.165)|GBM - Glioblastoma multiforme(144;0.244)		ACGGGAGCGTCTAGGTAACCG	0.662000													5	9					0	0	1	0	0
ETV3	2117	broad.mit.edu	37	1	157105486	157105486	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:157105486C>T	ENST00000368192.4	-	3	125	c.61G>A	c.(61-63)Gac>Aac	p.D21N	ETV3_ENST00000326786.4_Missense_Mutation_p.D21N|ETV3_ENST00000460850.1_5'UTR	NM_001145312.1	NP_001138784.1	P41162	ETV3_HUMAN	ets variant 3	21							sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|prostate(2)	9	Hepatocellular(266;0.158)	Prostate(1639;0.174)				TAGGCCCAGTCAGGAAACTGA	0.507000													26	79					0	0	1	0	0
PBRM1	55193	broad.mit.edu	37	3	52692314	52692314	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:52692314C>G	ENST00000356770.4	-	5	548	c.546G>C	c.(544-546)ttG>ttC	p.L182F	PBRM1_ENST00000296302.7_Missense_Mutation_p.L182F|PBRM1_ENST00000409767.1_Missense_Mutation_p.L182F|PBRM1_ENST00000410007.1_Missense_Mutation_p.L182F|PBRM1_ENST00000409114.3_Missense_Mutation_p.L182F|PBRM1_ENST00000394830.3_Missense_Mutation_p.L182F|PBRM1_ENST00000337303.4_Missense_Mutation_p.L182F|PBRM1_ENST00000409057.1_Missense_Mutation_p.L182F			Q86U86	PB1_HUMAN	polybromo 1	182					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			breast(5)|endometrium(5)|kidney(301)|liver(1)|lung(22)|pancreas(1)	335				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		GGATCTCCTTCAAGTAAGCTG	0.373000			"""Mis, N, F, S, D, O"""		"""clear cell renal carcinoma, breast"""								4	51					0	0	1	0	0
ZNF93	81931	broad.mit.edu	37	19	20044424	20044424	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:20044424G>C	ENST00000343769.5	+	4	688	c.660G>C	c.(658-660)aaG>aaC	p.K220N	AC007204.2_ENST00000592245.1_lincRNA	NM_031218.3	NP_112495.2	P35789	ZNF93_HUMAN	zinc finger protein 93	220						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(6)|kidney(2)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	24						ATACACATAAGAGAATTCATA	0.368000													11	31					0	0	1	0	0
VSTM1	284415	broad.mit.edu	37	19	54545036	54545036	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:54545036G>A	ENST00000338372.2	-	8	763	c.588C>T	c.(586-588)ctC>ctT	p.L196L	VSTM1_ENST00000425006.2_3'UTR|VSTM1_ENST00000366170.2_Silent_p.L108L|VSTM1_ENST00000376626.1_Silent_p.L165L	NM_198481.3	NP_940883.2	Q6UX27	VSTM1_HUMAN	V-set and transmembrane domain containing 1	196						integral to membrane				breast(1)|large_intestine(3)|lung(11)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.165)		GACTCACCGAGAGAGATACCC	0.463000													7	10					0	0	1	0	0
ETV2	2116	broad.mit.edu	37	19	36135582	36135582	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:36135582G>C	ENST00000379026.2	+	6	1380	c.941G>C	c.(940-942)aGa>aCa	p.R314T	ETV2_ENST00000479824.1_Missense_Mutation_p.R193T|ETV2_ENST00000403402.1_Missense_Mutation_p.R286T|ETV2_ENST00000379023.4_Missense_Mutation_p.R99T|ETV2_ENST00000402764.2_Missense_Mutation_p.R286T			B9EIN1	B9EIN1_HUMAN	ets variant 2	286							sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(2)	2	all_lung(56;2.22e-07)|Lung NSC(56;3.47e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GAGCGCAAGAGAAAGCCGGGC	0.672000													4	18					0	0	1	0	0
MTRR	4552	broad.mit.edu	37	5	7878391	7878391	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:7878391C>T	ENST00000264668.2	+	5	847	c.817C>T	c.(817-819)Ccc>Tcc	p.P273S	MTRR_ENST00000440940.2_Missense_Mutation_p.P246S|MTRR_ENST00000341013.6_3'UTR	NM_002454.2|NM_024010.2	NP_002445.2|NP_076915.2	Q9UBK8	MTRR_HUMAN	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	273	Hinge.				methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			NS(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(14)|ovary(1)|prostate(3)|stomach(1)	31					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	TCCTGGTTTACCCCCAGAATA	0.423000													41	242					0	0	1	0	0
KIF20B	9585	broad.mit.edu	37	10	91487639	91487639	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:91487639G>C	ENST00000416354.1	+	17	2329	c.2257G>C	c.(2257-2259)Gag>Cag	p.E753Q	KIF20B_ENST00000394289.2_Missense_Mutation_p.E753Q|KIF20B_ENST00000260753.4_Missense_Mutation_p.E713Q|KIF20B_ENST00000478929.1_3'UTR|KIF20B_ENST00000371728.3_Missense_Mutation_p.E753Q			Q96Q89	KI20B_HUMAN	kinesin family member 20B	753				E -> K (in Ref. 1; BAB69456).	cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	58						TCAAGAGCTTGAGACATCTAA	0.244000													4	21					0	0	1	0	0
DNTTIP2	30836	broad.mit.edu	37	1	94343201	94343201	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:94343201G>A	ENST00000436063.2	-	2	347	c.290C>T	c.(289-291)tCt>tTt	p.S97F	DNTTIP2_ENST00000460191.1_5'UTR	NM_014597.4	NP_055412.2	Q5QJE6	TDIF2_HUMAN	deoxynucleotidyltransferase, terminal, interacting protein 2	97					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(15)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	38		all_lung(203;0.0111)|Lung NSC(277;0.0347)		all cancers(265;0.00679)|GBM - Glioblastoma multiforme(16;0.0278)|Epithelial(280;0.128)		ATGGTGCTCAGACACAGAATA	0.458000													11	42					0	0	1	0	0
CHUK	1147	broad.mit.edu	37	10	101981902	101981902	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:101981902C>G	ENST00000370397.7	-	4	438	c.352G>C	c.(352-354)Gaa>Caa	p.E118Q		NM_001278.3	NP_001269.3	O15111	IKKA_HUMAN	conserved helix-loop-helix ubiquitous kinase	118	Protein kinase.				I-kappaB phosphorylation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|nucleus	ATP binding|identical protein binding|IkappaB kinase activity			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(9)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(1)	27		Colorectal(252;0.117)		Epithelial(162;2.05e-10)|all cancers(201;1.91e-08)		ATCTGGCTTTCTTTAAGTCCA	0.348000													4	24					0	0	1	0	0
DHDH	27294	broad.mit.edu	37	19	49445720	49445720	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:49445720C>T	ENST00000221403.2	+	5	683	c.643C>T	c.(643-645)Ctc>Ttc	p.L215F	DHDH_ENST00000522614.1_Intron|DHDH_ENST00000523250.1_Missense_Mutation_p.L76F	NM_014475.3	NP_055290.1	Q9UQ10	DHDH_HUMAN	dihydrodiol dehydrogenase (dimeric)	215					carbohydrate metabolic process		binding|D-xylose 1-dehydrogenase (NADP+) activity|electron carrier activity|NAD(P)+ transhydrogenase activity|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity			central_nervous_system(1)|large_intestine(3)|lung(3)|ovary(1)|soft_tissue(1)	9		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000158)|all cancers(93;0.000258)|Epithelial(262;0.0173)|GBM - Glioblastoma multiforme(486;0.0179)		TGTCACGGTGCTCCTGCAGTA	0.622000													6	21					0	0	1	0	0
ASH1L	55870	broad.mit.edu	37	1	155340407	155340407	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:155340407C>T	ENST00000368346.3	-	12	7228	c.6589G>A	c.(6589-6591)Gac>Aac	p.D2197N	ASH1L_ENST00000392403.3_Missense_Mutation_p.D2192N			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	2197	SET.				cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			CAGTAGTGGTCACTGTGATTA	0.408000													21	95					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32029210	32029210	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:32029210G>A	ENST00000375244.3	-	21	7657	c.7456C>T	c.(7456-7458)Cgg>Tgg	p.R2486W	TNXB_ENST00000375247.2_Missense_Mutation_p.R2486W			P22105	TENX_HUMAN	tenascin XB	2546	Fibronectin type-III 17.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						CCCACGCGCCGCCCCTCGTGG	0.647000													37	84					0	0	1	0	0
CEP97	79598	broad.mit.edu	37	3	101476575	101476575	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:101476575G>A	ENST00000341893.3	+	9	1877	c.1125G>A	c.(1123-1125)acG>acA	p.T375T	CEP97_ENST00000327230.4_Silent_p.T375T|CEP97_ENST00000494050.1_Intron			Q8IW35	CEP97_HUMAN	centrosomal protein 97kDa	375	CEP110 binding.					centrosome|nucleus	protein binding			cervix(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	29						TACACACTACGAGATATTCTC	0.398000													21	62					0	0	1	0	0
TEFM	79736	broad.mit.edu	37	17	29226414	29226414	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:29226414C>T	ENST00000581216.1	-	4	1477	c.856G>A	c.(856-858)Gaa>Aaa	p.E286K	TEFM_ENST00000580840.1_3'UTR	NM_024683.3	NP_078959.3	Q96QE5	TEFM_HUMAN	transcription elongation factor, mitochondrial	286					oxidative phosphorylation|regulation of transcription, DNA-dependent|transcription from mitochondrial promoter	mitochondrial nucleoid|ribonucleoprotein complex	DNA polymerase processivity factor activity|nucleic acid binding|protein binding										ATCATCAGTTCAAAATGCTTC	0.468000													34	69					0	0	1	0	0
PRRC2A	7916	broad.mit.edu	37	6	31599733	31599733	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:31599733G>A	ENST00000376033.2	+	16	3517	c.3283G>A	c.(3283-3285)Gag>Aag	p.E1095K	PRRC2A_ENST00000376007.4_Missense_Mutation_p.E1095K	NM_004638.3	NP_004629.3	P48634	PRC2A_HUMAN	proline-rich coiled-coil 2A	1095	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding			breast(6)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|lung(19)|ovary(3)|pancreas(2)|prostate(4)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	70						TTCAGAGTATGAGGAAATCCC	0.637000													5	25					0	0	1	0	0
USP40	55230	broad.mit.edu	37	2	234429685	234429685	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:234429685C>G	ENST00000251722.6	-	17	2391	c.2274G>C	c.(2272-2274)caG>caC	p.Q758H	USP40_ENST00000427112.2_Missense_Mutation_p.Q758H|USP40_ENST00000450966.1_Missense_Mutation_p.Q770H			Q9NVE5	UBP40_HUMAN	ubiquitin specific peptidase 40	758					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(1)|endometrium(6)|kidney(5)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	30		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0539)		Epithelial(121;1.71e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000407)|Lung(119;0.00277)|LUSC - Lung squamous cell carcinoma(224;0.00646)		CAGATTCTAACTGGCATAAAT	0.343000													9	27					0	0	1	0	0
NUDT6	11162	broad.mit.edu	37	4	123814162	123814162	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr4:123814162C>T	ENST00000304430.5	-	5	805	c.772G>A	c.(772-774)Gaa>Aaa	p.E258K	NUDT6_ENST00000502270.1_Missense_Mutation_p.E89K|NUDT6_ENST00000339154.2_Missense_Mutation_p.E89K|FGF2_ENST00000264498.3_3'UTR|FGF2_ENST00000608478.1_3'UTR	NM_007083.4	NP_009014.2	P53370	NUDT6_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 6	258	Nudix hydrolase.			KTEN -> RTKH (in Ref. 4; AAA67062).		mitochondrion|nucleus	growth factor activity|hydrolase activity			endometrium(2)|lung(1)|prostate(1)|skin(1)|stomach(1)	6						GTTGTATTTTCAGTCTTCGCC	0.448000													8	69					0	0	1	0	0
LBH	81606	broad.mit.edu	37	2	30457350	30457350	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:30457350C>T	ENST00000395323.3	+	2	314	c.106C>T	c.(106-108)Cgc>Tgc	p.R36C	LBH_ENST00000467242.1_3'UTR|LBH_ENST00000401506.1_Missense_Mutation_p.R42C|LBH_ENST00000406087.1_Missense_Mutation_p.R36C|LBH_ENST00000407930.2_Missense_Mutation_p.R19C|LBH_ENST00000404397.1_Missense_Mutation_p.R36C	NM_030915.3	NP_112177.2	Q53QV2	LBH_HUMAN	limb bud and heart development	36					multicellular organismal development|transcription, DNA-dependent	cytoplasm|nucleolus				endometrium(2)|large_intestine(1)|lung(2)	5	Acute lymphoblastic leukemia(172;0.155)					CCTCAGCCCCCGCAAGGATGG	0.562000													16	52					0	0	1	0	0
TJP1	7082	broad.mit.edu	37	15	30064302	30064302	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:30064302G>A	ENST00000346128.6	-	4	751	c.277C>T	c.(277-279)Cag>Tag	p.Q93*	TJP1_ENST00000356107.6_Nonsense_Mutation_p.Q93*|TJP1_ENST00000400011.2_Nonsense_Mutation_p.Q97*|TJP1_ENST00000545208.2_Nonsense_Mutation_p.Q93*|TJP1_ENST00000495972.2_Nonsense_Mutation_p.Q93*	NM_003257.3|NM_175610.2	NP_003248.3|NP_783297.2	Q07157	ZO1_HUMAN	tight junction protein 1	93	PDZ 1.				cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				breast(4)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(1)	68		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		CTTAGTTGCTGAACAGCAAAA	0.348000													12	29					0	0	1	0	0
STMN3	50861	broad.mit.edu	37	20	62273466	62273466	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:62273466C>G	ENST00000370053.1	-	4	559	c.478G>C	c.(478-480)Gag>Cag	p.E160Q	STMN3_ENST00000540534.1_Missense_Mutation_p.E149Q	NM_001276310.1|NM_015894.2	NP_001263239.1|NP_056978.2	Q9NZ72	STMN3_HUMAN	stathmin-like 3	160					cytoplasmic microtubule organization|intracellular signal transduction|negative regulation of Rac protein signal transduction|neuron projection development|regulation of cytoskeleton organization|regulation of Rac GTPase activity	cytoplasm	protein domain specific binding	p.E160K(1)		kidney(1)|large_intestine(1)|lung(5)|prostate(1)	8	all_cancers(38;2.31e-11)|all_epithelial(29;7.76e-13)		Epithelial(9;1.9e-09)|all cancers(9;1.22e-08)|BRCA - Breast invasive adenocarcinoma(10;8.86e-06)|OV - Ovarian serous cystadenocarcinoma(5;0.00559)			CGCACCTTCTCGCGCAGCCGC	0.756000													3	15					0	0	1	0	0
ATP8B1	5205	broad.mit.edu	37	18	55368464	55368464	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr18:55368464C>T	ENST00000536015.1	-	5	594	c.475G>A	c.(475-477)Gac>Aac	p.D159N	RP11-35G9.5_ENST00000588925.1_RNA|ATP8B1_ENST00000283684.4_Missense_Mutation_p.D159N|RP11-35G9.3_ENST00000599199.1_RNA|ATP8B1_ENST00000589147.1_5'UTR	NM_005603.4	NP_005594	O43520	AT8B1_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 1	159					ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(19)|ovary(3)|prostate(1)	53		Colorectal(73;0.229)				TCCACCAGGTCTTTGATTGCA	0.463000													14	27					0	0	1	0	0
DUSP8	1850	broad.mit.edu	37	11	1586886	1586886	+	Silent	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:1586886C>G	ENST00000397374.3	-	2	298	c.171G>C	c.(169-171)cgG>cgC	p.R57R	DUSP8_ENST00000331588.4_Silent_p.R57R	NM_004420.2	NP_004411.2	Q13202	DUS8_HUMAN	dual specificity phosphatase 8	57	Rhodanese.				inactivation of MAPK activity	cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			endometrium(1)|lung(2)|prostate(1)|urinary_tract(1)	5		all_epithelial(84;0.000134)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000621)|Lung(200;0.0687)|LUSC - Lung squamous cell carcinoma(625;0.0825)		GCTGCAGCCGCCGCTTCACCA	0.647000													18	42					0	0	1	0	0
HIST1H2AD	3013	broad.mit.edu	37	6	26199400	26199400	+	Silent	SNP	G	G	C	rs150465023		TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:26199400G>C	ENST00000341023.1	-	1	71	c.72C>G	c.(70-72)ctC>ctG	p.L24L	HIST1H3D_ENST00000377831.5_5'UTR	NM_021065.2	NP_066409.1	P20671	H2A1D_HUMAN	histone cluster 1, H2ad	24					nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)	6		all_hematologic(11;0.196)				CAGGGAACTGGAGTCCGGCCC	0.612000													17	31					0	0	1	0	0
ACTN2	88	broad.mit.edu	37	1	236908074	236908074	+	Silent	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:236908074C>G	ENST00000366578.4	+	12	1570	c.1404C>G	c.(1402-1404)ctC>ctG	p.L468L	ACTN2_ENST00000542672.1_Silent_p.L468L|ACTN2_ENST00000546208.1_5'UTR	NM_001103.2|NM_001278343.1	NP_001094.1|NP_001265272.1	P35609	ACTN2_HUMAN	actinin, alpha 2	468					focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			endometrium(4)|kidney(2)|large_intestine(15)|lung(55)|ovary(4)|prostate(3)|skin(3)	86	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			CGCAGGAGCTCAAGTATGTGC	0.647000													12	48					0	0	1	0	0
RHOA	387	broad.mit.edu	37	3	49397643	49397643	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:49397643C>T	ENST00000418115.1	-	5	965	c.581G>A	c.(580-582)tGa>tAa	p.*194*	RHOA_ENST00000422781.1_3'UTR|RHOA_ENST00000454011.2_3'UTR	NM_001664.2	NP_001655.1	P61586	RHOA_HUMAN	ras homolog family member A	0					axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding			cervix(1)|kidney(1)|large_intestine(5)|lung(1)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	12				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)	AGCAAGGTTTCACAAGACAAG	0.403000													36	92					0	0	1	0	0
OR4D1	26689	broad.mit.edu	37	17	56233150	56233150	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:56233150C>T	ENST00000268912.5	+	1	657	c.636C>T	c.(634-636)ctC>ctT	p.L212L		NM_012374.1	NP_036506.1	Q15615	OR4D1_HUMAN	olfactory receptor, family 4, subfamily D, member 1	212					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|large_intestine(4)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	13						TCTGGTTCCTCCTCCTTCTGA	0.532000													24	53					0	0	1	0	0
PHKG2	5261	broad.mit.edu	37	16	30767535	30767535	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr16:30767535G>C	ENST00000563588.1	+	7	828	c.589G>C	c.(589-591)Gag>Cag	p.E197Q	PHKG2_ENST00000328273.7_Missense_Mutation_p.E197Q|PHKG2_ENST00000424889.3_Missense_Mutation_p.E197Q	NM_000294.2	NP_000285.1	P15735	PHKG2_HUMAN	phosphorylase kinase, gamma 2 (testis)	197	Protein kinase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	ATP binding|calmodulin binding|phosphorylase kinase activity			ovary(1)|skin(1)	2			Colorectal(24;0.198)			TCTAGCGCCAGAGATCCTTAA	0.587000													36	115					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577511	7577511	+	Missense_Mutation	SNP	A	A	T	rs28934577		TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:7577511A>T	ENST00000420246.2	-	7	902	c.770T>A	c.(769-771)cTg>cAg	p.L257Q	TP53_ENST00000445888.2_Missense_Mutation_p.L257Q|TP53_ENST00000413465.2_Missense_Mutation_p.L257Q|TP53_ENST00000269305.4_Missense_Mutation_p.L257Q|TP53_ENST00000455263.2_Missense_Mutation_p.L257Q|TP53_ENST00000359597.4_Missense_Mutation_p.L257Q	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	257	Interaction with AXIN1 (By similarity).|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		L -> P (in sporadic cancers; somatic mutation).|L -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934577).|L -> R (in sporadic cancers; somatic mutation).|L -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.L257Q(8)|p.L257P(8)|p.L257fs*6(2)|p.?(1)|p.T256fs*87(1)|p.L257R(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGAGTCTTCCAGTGTGATGAT	0.582000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			7	26					0	0	1	0	0
OR52E4	390081	broad.mit.edu	37	11	5905783	5905783	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:5905783C>G	ENST00000316987.2	+	1	283	c.261C>G	c.(259-261)ttC>ttG	p.F87L		NM_001005165.1	NP_001005165.1	Q8NGH9	O52E4_HUMAN	olfactory receptor, family 52, subfamily E, member 4	87					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(7)|liver(2)|lung(13)|ovary(2)|prostate(1)|skin(2)	30		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.24e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TAGGAATCTTCTGGTTCAACC	0.458000													40	106					0	0	1	0	0
NUP155	9631	broad.mit.edu	37	5	37371053	37371053	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:37371053C>T	ENST00000231498.3	-	1	230	c.27G>A	c.(25-27)gcG>gcA	p.A9A	NUP155_ENST00000513532.1_Silent_p.A9A	NM_153485.1	NP_705618.1	O75694	NU155_HUMAN	nucleoporin 155kDa	9					carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			endometrium(1)|kidney(16)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	62	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AGGCCGGCATCGCCGCGCCCA	0.537000													17	80					0	0	1	0	0
CDKN1B	1027	broad.mit.edu	37	12	12871794	12871794	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:12871794G>T	ENST00000228872.4	+	2	1227	c.511G>T	c.(511-513)Gaa>Taa	p.E171*	CDKN1B_ENST00000477087.1_3'UTR|CDKN1B_ENST00000396340.1_Intron	NM_004064.3	NP_004055.1	P46527	CDN1B_HUMAN	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	171					autophagic cell death|cell cycle arrest|cellular response to lithium ion|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein catabolic process|S phase of mitotic cell cycle	cytosol|endosome|nucleoplasm	cyclin-dependent protein kinase inhibitor activity|protein phosphatase binding|transforming growth factor beta receptor, cytoplasmic mediator activity			breast(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(5)	13		Prostate(47;0.0322)|all_epithelial(100;0.159)		BRCA - Breast invasive adenocarcinoma(232;0.0336)		CAACAGAACAGAAGAAAATGT	0.443000													54	47					8.28887e-21	8.74282e-21	1	1	0
BRDT	676	broad.mit.edu	37	1	92459724	92459724	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:92459724C>T	ENST00000370389.2	+	15	2905	c.1981C>T	c.(1981-1983)Cac>Tac	p.H661Y	BRDT_ENST00000399546.2_Missense_Mutation_p.H734Y|BRDT_ENST00000402388.1_Missense_Mutation_p.H734Y|BRDT_ENST00000362005.3_Missense_Mutation_p.H734Y|BRDT_ENST00000394530.3_Missense_Mutation_p.H688Y	NM_001242810.1	NP_001229739	Q58F21	BRDT_HUMAN	bromodomain, testis-specific	734	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(24)|ovary(1)|prostate(4)|skin(2)|stomach(2)|urinary_tract(2)	56		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)		GCCACCAAATCACCACCAATT	0.363000													18	83					0	0	1	0	0
TAF4B	6875	broad.mit.edu	37	18	23915183	23915183	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr18:23915183G>A	ENST00000269142.5	+	13	3302	c.2304G>A	c.(2302-2304)caG>caA	p.Q768Q	TAF4B_ENST00000578121.1_Silent_p.Q773Q	NM_005640.1	NP_005631.1	Q92750	TAF4B_HUMAN	TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa	768					transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleolus|transcription factor TFIID complex	DNA binding|NF-kappaB binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(13)|prostate(1)|skin(1)	29	all_cancers(21;0.00151)|Lung NSC(5;0.000401)|all_lung(6;0.00115)|Ovarian(20;0.124)		Epithelial(2;9.57e-07)|all cancers(3;5.15e-06)|OV - Ovarian serous cystadenocarcinoma(3;1.96e-05)|LUSC - Lung squamous cell carcinoma(2;0.00594)|Lung(2;0.0267)			GATTAAAGCAGAAAGCCAAAG	0.383000													8	23					0	0	1	0	0
SEMG2	6407	broad.mit.edu	37	20	43850441	43850441	+	Silent	SNP	T	T	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:43850441T>C	ENST00000372769.3	+	2	258	c.168T>C	c.(166-168)caT>caC	p.H56H		NM_003008.2	NP_002999.1	Q02383	SEMG2_HUMAN	semenogelin II	56					sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			autonomic_ganglia(1)|breast(3)|endometrium(6)|kidney(2)|large_intestine(6)|lung(9)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	36		Myeloproliferative disorder(115;0.0122)				ACCAACAACATACTAAATCCA	0.403000													25	82					0	0	1	0	0
OR1C1	26188	broad.mit.edu	37	1	247920938	247920938	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:247920938G>A	ENST00000408896.2	-	1	1044	c.771C>T	c.(769-771)gcC>gcT	p.A257A		NM_012353.2	NP_036485.2	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C, member 1	257					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(32)|skin(2)|upper_aerodigestive_tract(1)	46	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			TGAAATAGACGGCGATGGCTG	0.512000													25	53					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70504079	70504079	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:70504079C>T	ENST00000310961.5	+	22	2891	c.2473C>T	c.(2473-2475)Ccc>Tcc	p.P825S	LRRC7_ENST00000415775.2_Missense_Mutation_p.P104S|LRRC7_ENST00000035383.5_Missense_Mutation_p.P820S			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	820						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						TGTTGGTGTTCCCCTGGAACT	0.493000													29	59					0	0	1	0	0
NIPA1	123606	broad.mit.edu	37	15	23049167	23049167	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:23049167G>A	ENST00000437912.2	-	5	1724	c.427C>T	c.(427-429)Cat>Tat	p.H143Y	NIPA1_ENST00000538684.1_Missense_Mutation_p.H48Y|NIPA1_ENST00000337435.4_Missense_Mutation_p.H218Y|NIPA1_ENST00000561183.1_Missense_Mutation_p.H143Y			Q7RTP0	NIPA1_HUMAN	non imprinted in Prader-Willi/Angelman syndrome 1	218					cell death	early endosome|integral to membrane|plasma membrane				endometrium(2)|kidney(2)|large_intestine(1)|lung(9)|skin(1)	15		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;4.18e-06)|Epithelial(43;3.97e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00165)		GGGTTGTTATGCAAGATGTCT	0.587000													18	43					0	0	1	0	0
ALG1L	200810	broad.mit.edu	37	3	125649405	125649405	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:125649405G>C	ENST00000340333.3	-	5	506	c.343C>G	c.(343-345)Ctg>Gtg	p.L115V		NM_001015050.2|NM_001195223.1	NP_001015050.2|NP_001182152.1	Q6GMV1	ALG1L_HUMAN	ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase-like	115							transferase activity, transferring glycosyl groups			large_intestine(2)|lung(2)	4						GCTACCTGCAGAGCTGCCAGT	0.582000													17	33					0	0	1	0	0
LIG4	3981	broad.mit.edu	37	13	108861843	108861843	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr13:108861843C>T	ENST00000356922.4	-	2	2046	c.1774G>A	c.(1774-1776)Gag>Aag	p.E592K	LIG4_ENST00000405925.1_Missense_Mutation_p.E592K|LIG4_ENST00000442234.1_Missense_Mutation_p.E592K	NM_002312.3|NM_206937.1	NP_002303.2|NP_996820.1	P49917	DNLI4_HUMAN	ligase IV, DNA, ATP-dependent	592					cell cycle|cell division|cell proliferation|central nervous system development|chromosome organization|DNA ligation involved in DNA recombination|DNA ligation involved in DNA repair|DNA replication|double-strand break repair via nonhomologous end joining|in utero embryonic development|initiation of viral infection|isotype switching|negative regulation of neuron apoptosis|neuron apoptosis|nucleotide-excision repair, DNA gap filling|positive regulation of fibroblast proliferation|positive regulation of neurogenesis|pro-B cell differentiation|provirus integration|response to gamma radiation|response to X-ray|single strand break repair|somatic stem cell maintenance|T cell differentiation in thymus|T cell receptor V(D)J recombination	condensed chromosome|cytoplasm|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|focal adhesion|nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding|protein C-terminus binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	42	all_lung(23;0.000238)|all_neural(89;0.00256)|Lung NSC(43;0.0056)|Medulloblastoma(90;0.00596)|Lung SC(71;0.104)					GTCATGCACTCATGCCACTCC	0.448000								Non-homologous end-joining					21	49					0	0	1	0	0
CSNK1D	1453	broad.mit.edu	37	17	80223668	80223668	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:80223668C>T	ENST00000314028.6	-	2	430	c.81G>A	c.(79-81)acG>acA	p.T27T	CSNK1D_ENST00000392334.2_Silent_p.T27T|CSNK1D_ENST00000398519.5_Silent_p.T27T	NM_001893.4	NP_001884.2	P48730	KC1D_HUMAN	casein kinase 1, delta	27	Protein kinase.				circadian regulation of gene expression|DNA repair|G2/M transition of mitotic cell cycle|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|regulation of circadian rhythm|Wnt receptor signaling pathway	centrosome|cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|large_intestine(2)|lung(7)	11	Breast(20;0.00136)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.227)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0155)			CAGCAATGTCCGTACCTTGGC	0.438000													37	76					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	6966276	6966276	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr18:6966276G>A	ENST00000389658.3	-	49	7013	c.6920C>T	c.(6919-6921)tCc>tTc	p.S2307F		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	2307	Laminin G-like 2.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AAAATGGAAGGAAGGGTCTTC	0.448000													9	20					0	0	1	0	0
PDE11A	50940	broad.mit.edu	37	2	178528629	178528629	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:178528629C>A	ENST00000286063.6	-	19	2928	c.2611G>T	c.(2611-2613)Gag>Tag	p.E871*	PDE11A_ENST00000389683.3_Nonsense_Mutation_p.E427*|PDE11A_ENST00000450799.2_Nonsense_Mutation_p.E62*|PDE11A_ENST00000358450.4_Nonsense_Mutation_p.E621*|PDE11A_ENST00000449286.2_Nonsense_Mutation_p.E513*|PDE11A_ENST00000409504.1_Nonsense_Mutation_p.E513*	NM_016953.3	NP_058649.3	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A		Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			TCAATCCACTCCAGTTGCAAC	0.438000									Primary Pigmented Nodular Adrenocortical Disease, Familial				13	51					7.93312e-07	8.13653e-07	1	1	0
PTPN22	26191	broad.mit.edu	37	1	114380755	114380755	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:114380755C>T	ENST00000359785.5	-	13	1402	c.1267G>A	c.(1267-1269)Gag>Aag	p.E423K	PTPN22_ENST00000525799.1_Missense_Mutation_p.E296K|PTPN22_ENST00000528414.1_Missense_Mutation_p.E368K|PTPN22_ENST00000420377.2_Missense_Mutation_p.E423K|PTPN22_ENST00000538253.1_Missense_Mutation_p.E179K|PTPN22_ENST00000460620.1_Intron	NM_001193431.1|NM_015967.5	NP_001180360.1|NP_057051	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	423					negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			NS(1)|breast(1)|kidney(3)|large_intestine(4)|lung(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	21	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAACATCCCTCAAACAAAAGA	0.388000													19	51					0	0	1	0	0
RGL1	23179	broad.mit.edu	37	1	183853908	183853908	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:183853908C>T	ENST00000304685.4	+	8	1341	c.892C>T	c.(892-894)Cga>Tga	p.R298*	RGL1_ENST00000360851.3_Nonsense_Mutation_p.R263*|RGL1_ENST00000539189.1_Nonsense_Mutation_p.R263*|RGL1_ENST00000536277.1_Nonsense_Mutation_p.R261*	NM_015149.3	NP_055964.3	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation stimulator-like 1		Ras-GEF.				cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(17)|ovary(4)|prostate(3)|stomach(1)	51						CATTTGGTCTCGAAGGGATAA	0.458000													22	68					0	0	1	0	0
PDE11A	50940	broad.mit.edu	37	2	178545621	178545621	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:178545621C>G	ENST00000286063.6	-	16	2673	c.2356G>C	c.(2356-2358)Gaa>Caa	p.E786Q	PDE11A_ENST00000389683.3_Missense_Mutation_p.E342Q|PDE11A_ENST00000358450.4_Missense_Mutation_p.E536Q|PDE11A_ENST00000449286.2_Missense_Mutation_p.E428Q|PDE11A_ENST00000409504.1_Missense_Mutation_p.E428Q	NM_016953.3	NP_058649.3	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A		Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			TCAAAGAATTCAGTTCTCCTC	0.353000									Primary Pigmented Nodular Adrenocortical Disease, Familial				4	23					0	0	1	0	0
RGPD4	285190	broad.mit.edu	37	2	108496500	108496500	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:108496500T>A	ENST00000408999.3	+	21	5078	c.5001T>A	c.(4999-5001)gaT>gaA	p.D1667E	RGPD4_ENST00000354986.4_Missense_Mutation_p.D1667E	NM_182588.2	NP_872394.2	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1667					intracellular transport		binding			breast(1)|endometrium(7)|kidney(4)|lung(23)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(3)	43						AAAGTGCAGATCACTTAAACG	0.453000													35	123					0	0	1	0	0
PRKD3	23683	broad.mit.edu	37	2	37513430	37513430	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:37513430C>G	ENST00000379066.1	-	6	1562	c.800G>C	c.(799-801)aGa>aCa	p.R267T	PRKD3_ENST00000234179.2_Missense_Mutation_p.R267T			O94806	KPCD3_HUMAN	protein kinase D3	267					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			breast(3)|central_nervous_system(2)|kidney(3)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33		all_hematologic(82;0.21)				AACTTTCACTCTGCACATTAC	0.448000													18	47					0	0	1	0	0
OR4B1	119765	broad.mit.edu	37	11	48238743	48238743	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:48238743C>G	ENST00000309562.2	+	1	400	c.382C>G	c.(382-384)Ctt>Gtt	p.L128V		NM_001005470.1	NP_001005470.1	Q8NGF8	OR4B1_HUMAN	olfactory receptor, family 4, subfamily B, member 1	128					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(3)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	28						TTGCAAGCCTCTTCATTATAT	0.453000													41	87					0	0	1	0	0
CALN1	83698	broad.mit.edu	37	7	71571273	71571273	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr7:71571273C>T	ENST00000395275.2	-	4	639	c.251G>A	c.(250-252)cGa>cAa	p.R84Q	CALN1_ENST00000395276.2_Missense_Mutation_p.R42Q|CALN1_ENST00000329008.5_Missense_Mutation_p.R42Q|CALN1_ENST00000431984.1_Missense_Mutation_p.R42Q|CALN1_ENST00000405452.2_Missense_Mutation_p.R42Q|CALN1_ENST00000412588.1_Missense_Mutation_p.R84Q	NM_031468.3	NP_113656.2	Q9BXU9	CABP8_HUMAN	calneuron 1	42	EF-hand 2.					Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			biliary_tract(1)|breast(1)|endometrium(3)|large_intestine(6)|lung(19)|skin(2)	32		all_cancers(73;0.069)|Lung NSC(55;0.0658)|all_lung(88;0.0912)|all_epithelial(88;0.161)				AAAGGCCTCTCGGATTTCTAC	0.527000													17	29					0	0	1	0	0
ATP2B4	493	broad.mit.edu	37	1	203693083	203693083	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:203693083C>T	ENST00000357681.5	+	19	4222	c.3099C>T	c.(3097-3099)ctC>ctT	p.L1033L	ATP2B4_ENST00000391954.2_Intron|ATP2B4_ENST00000367218.3_Silent_p.L1033L|ATP2B4_ENST00000341360.2_Silent_p.L1033L|ATP2B4_ENST00000367219.3_Silent_p.L1021L	NM_001684.4	NP_001675.3	P23634	AT2B4_HUMAN	ATPase, Ca++ transporting, plasma membrane 4	1033					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(20)|ovary(2)|prostate(6)|skin(1)|stomach(1)|urinary_tract(3)	56	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			TGTGGTGTCTCTTCATTGGGA	0.532000													24	100					0	0	1	0	0
RAP1GAP2	23108	broad.mit.edu	37	17	2861064	2861064	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:2861064C>G	ENST00000254695.8	+	4	267	c.177C>G	c.(175-177)ttC>ttG	p.F59L	RAP1GAP2_ENST00000366401.4_Missense_Mutation_p.F59L|RAP1GAP2_ENST00000540393.2_Missense_Mutation_p.F40L|RAP1GAP2_ENST00000542807.1_Missense_Mutation_p.F59L	NM_015085.4	NP_055900.4	Q684P5	RPGP2_HUMAN	RAP1 GTPase activating protein 2	59					regulation of small GTPase mediated signal transduction	centrosome|cytosol|perinuclear region of cytoplasm	GTPase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	11						CGTCGGAGTTCTTTGAGATGC	0.567000													26	57					0	0	1	0	0
TMEM131	23505	broad.mit.edu	37	2	98382950	98382950	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:98382950T>C	ENST00000186436.5	-	34	4792	c.4564A>G	c.(4564-4566)Aaa>Gaa	p.K1522E		NM_015348.1	NP_056163.1	Q92545	TM131_HUMAN	transmembrane protein 131	1522						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(4)|prostate(1)|skin(1)|stomach(1)	57						CCTTTTGTTTTCTGGGCATTT	0.393000													15	46					0	0	1	0	0
FAM173B	134145	broad.mit.edu	37	5	10235356	10235356	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:10235356G>T	ENST00000511437.1	-	4	474	c.462C>A	c.(460-462)taC>taA	p.Y154*	FAM173B_ENST00000280330.8_5'UTR|FAM173B_ENST00000510052.1_5'UTR|FAM173B_ENST00000510047.1_Intron	NM_199133.3	NP_954584.2	Q6P4H8	F173B_HUMAN	family with sequence similarity 173, member B	154						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	16						CAACGTTCGAGTACTGCGAAA	0.428000													6	42					0.000157383	0.000159531	1	1	0
CNPPD1	27013	broad.mit.edu	37	2	220039607	220039607	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:220039607A>G	ENST00000409789.1	-	6	830	c.403T>C	c.(403-405)Tat>Cat	p.Y135H	CNPPD1_ENST00000360507.5_Missense_Mutation_p.Y135H			Q9BV87	CNPD1_HUMAN	cyclin Pas1/PHO80 domain containing 1	135					regulation of cyclin-dependent protein kinase activity	integral to membrane	protein kinase binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)	12						CCTTCATCATAGAGGTACTTA	0.582000													19	42					0	0	1	0	0
PIKFYVE	200576	broad.mit.edu	37	2	209190134	209190134	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:209190134C>G	ENST00000264380.4	+	20	2757	c.2599C>G	c.(2599-2601)Caa>Gaa	p.Q867E		NM_015040.3	NP_055855.2	Q9Y2I7	FYV1_HUMAN	phosphoinositide kinase, FYVE finger containing	867					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(14)|kidney(6)|large_intestine(25)|lung(40)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	107						TTATCATTCTCAACTAGAAAT	0.433000													19	64					0	0	1	0	0
DIDO1	11083	broad.mit.edu	37	20	61513083	61513083	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:61513083C>T	ENST00000266070.4	-	16	4550	c.4225G>A	c.(4225-4227)Gag>Aag	p.E1409K	DIDO1_ENST00000395343.1_Missense_Mutation_p.E1409K	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	1409					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding	p.E1409*(1)		NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					CTTTCCACCTCGTGGCGCCGC	0.602000													44	72					0	0	1	0	0
ERN2	10595	broad.mit.edu	37	16	23713758	23713758	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr16:23713758C>G	ENST00000256797.4	-	10	1346	c.1178G>C	c.(1177-1179)aGa>aCa	p.R393T	ERN2_ENST00000457008.2_Missense_Mutation_p.R345T	NM_033266.3	NP_150296.3	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signaling 2	345					apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		TGAGGGGTATCTAACAGCAGT	0.582000													52	124					0	0	1	0	0
ATP6V1B1	525	broad.mit.edu	37	2	71189911	71189911	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:71189911G>A	ENST00000234396.4	+	9	863	c.790G>A	c.(790-792)Gag>Aag	p.E264K	ATP6V1B1_ENST00000412314.1_Missense_Mutation_p.E264K|AC007040.11_ENST00000606025.1_Intron	NM_001692.3	NP_001683.2	P15313	VATB1_HUMAN	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1	264					ATP hydrolysis coupled proton transport|calcium ion homeostasis|cellular iron ion homeostasis|excretion|inner ear morphogenesis|insulin receptor signaling pathway|ossification|pH reduction|sensory perception of sound|transferrin transport	apical plasma membrane|basolateral plasma membrane|cytosol|endomembrane system|lateral plasma membrane|microvillus|proton-transporting V-type ATPase, V1 domain|vacuolar proton-transporting V-type ATPase complex	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(5)|prostate(1)|skin(1)	19						CTCCAGGATCGAGCGGATCAT	0.582000													10	59					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82789485	82789485	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:82789485A>G	ENST00000265077.3	+	4	1131	c.566A>G	c.(565-567)tAt>tGt	p.Y189C	VCAN_ENST00000512590.2_Missense_Mutation_p.Y141C|VCAN_ENST00000342785.4_Missense_Mutation_p.Y189C|VCAN_ENST00000343200.5_Missense_Mutation_p.Y189C|VCAN_ENST00000502527.2_Missense_Mutation_p.Y189C|VCAN_ENST00000513984.1_Missense_Mutation_p.Y189C	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	189	Link 1.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TTTGCTGCCTATGAAGATGGA	0.522000													30	79					0	0	1	0	0
SLC11A2	4891	broad.mit.edu	37	12	51389481	51389481	+	Silent	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:51389481G>C	ENST00000394904.3	-	10	1057	c.1008C>G	c.(1006-1008)tcC>tcG	p.S336S	SLC11A2_ENST00000262052.5_Silent_p.S307S|SLC11A2_ENST00000547198.1_Silent_p.S307S|SLC11A2_ENST00000262051.7_Silent_p.S307S|SLC11A2_ENST00000541174.2_Silent_p.S307S|SLC11A2_ENST00000546743.1_Silent_p.S228S|SLC11A2_ENST00000547688.1_Silent_p.S336S|SLC11A2_ENST00000545993.2_Silent_p.S303S	NM_001174125.1	NP_001167596.1	P49281	NRAM2_HUMAN	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2	307					activation of caspase activity|cellular iron ion homeostasis|cellular response to oxidative stress|detection of oxygen|ferrous iron import|multicellular organismal iron ion homeostasis|response to hypoxia|response to iron ion	apical plasma membrane|basal part of cell|cell surface|cytoplasmic vesicle|early endosome|late endosome|late endosome membrane|lysosomal membrane|lysosome|nucleus|paraferritin complex|perinuclear region of cytoplasm|plasma membrane|recycling endosome|trans-Golgi network	cadmium ion transmembrane transporter activity|cobalt ion transmembrane transporter activity|copper ion transmembrane transporter activity|ferrous iron transmembrane transporter activity|lead ion transmembrane transporter activity|manganese ion transmembrane transporter activity|nickel ion transmembrane transporter activity|protein binding|solute:hydrogen symporter activity|vanadium ion transmembrane transporter activity|zinc ion transmembrane transporter activity			breast(2)|cervix(1)|endometrium(3)|kidney(16)|large_intestine(4)|lung(9)|upper_aerodigestive_tract(1)	36						TGATGATGAAGGAAACAAAGA	0.413000													22	29					0	0	1	0	0
PPRC1	23082	broad.mit.edu	37	10	103900787	103900787	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:103900787C>T	ENST00000278070.2	+	5	2561	c.2522C>T	c.(2521-2523)tCa>tTa	p.S841L	PPRC1_ENST00000413464.2_Missense_Mutation_p.S841L	NM_015062.3	NP_055877.3	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator-related 1	841	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(10)|lung(19)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		CCTGTGGCCTCATCTCCCACT	0.597000													33	49					0	0	1	0	0
HSD3B2	3284	broad.mit.edu	37	1	119965133	119965133	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:119965133C>G	ENST00000543831.1	+	4	1258	c.1009C>G	c.(1009-1011)Ctg>Gtg	p.L337V	HSD3B2_ENST00000369416.3_Missense_Mutation_p.L337V	NM_001166120.1	NP_001159592.1	P26439	3BHS2_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	337					androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(19)|ovary(2)|skin(1)	27	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	TCAGCGAGATCTGGCGTATAA	0.512000													14	47					0	0	1	0	0
ASXL1	171023	broad.mit.edu	37	20	31024321	31024321	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:31024321C>T	ENST00000375687.4	+	13	4230	c.3806C>T	c.(3805-3807)tCg>tTg	p.S1269L	ASXL1_ENST00000306058.5_Missense_Mutation_p.S1264L	NM_015338.5	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 (Drosophila)	1269					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding	p.L1266fs*9(1)		NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(655)|kidney(5)|large_intestine(18)|liver(1)|lung(27)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	722						CTTACTACCTCGAGAACACCT	0.493000			"""F, N, Mis"""		"""MDS, CMML"""								19	60					0	0	1	0	0
ZNF184	7738	broad.mit.edu	37	6	27419547	27419547	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:27419547C>T	ENST00000211936.6	-	6	2075	c.1791G>A	c.(1789-1791)caG>caA	p.Q597Q	ZNF184_ENST00000377419.1_Silent_p.Q597Q	NM_007149.2	NP_009080.2	Q99676	ZN184_HUMAN	zinc finger protein 184	597					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|kidney(9)|large_intestine(13)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	48						GGTGTATGTTCTGGTTGAATG	0.433000													29	69					0	0	1	0	0
KDM1B	221656	broad.mit.edu	37	6	18160153	18160153	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:18160153G>C	ENST00000388870.2	+	3	268	c.27G>C	c.(25-27)aaG>aaC	p.K9N	KDM1B_ENST00000397244.1_Missense_Mutation_p.K9N|KDM1B_ENST00000297792.5_Missense_Mutation_p.K9N|KDM1B_ENST00000546309.2_Intron			Q8NB78	KDM1B_HUMAN	lysine (K)-specific demethylase 1B	9					multicellular organismal development|regulation of DNA methylation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-monomethyl-K4 specific)|oxidoreductase activity|zinc ion binding			breast(2)|endometrium(5)|large_intestine(6)|lung(8)|skin(3)|upper_aerodigestive_tract(1)	25						GGAGGACAAAGAAAAAAGCAT	0.378000													6	22					0	0	1	0	0
WDR52	55779	broad.mit.edu	37	3	113098284	113098284	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:113098284G>A	ENST00000393845.2	-	17	2233	c.2167C>T	c.(2167-2169)Cag>Tag	p.Q723*	WDR52_ENST00000295868.2_Nonsense_Mutation_p.Q723*	NM_001164496.1	NP_001157968.1	Q96MT7	WDR52_HUMAN	WD repeat domain 52	723	Glu-rich.									breast(2)|central_nervous_system(3)|endometrium(3)|kidney(5)|large_intestine(7)|lung(26)|prostate(1)|urinary_tract(2)	49						tcctcctcctGAAATTCTTTT	0.453000													29	72					0	0	1	0	0
TPR	7175	broad.mit.edu	37	1	186313156	186313156	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:186313156G>C	ENST00000367478.4	-	26	3780	c.3484C>G	c.(3484-3486)Cag>Gag	p.Q1162E		NM_003292.2	NP_003283.2	P12270	TPR_HUMAN	translocated promoter region, nuclear basket protein						carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			autonomic_ganglia(1)|breast(5)|central_nervous_system(4)|cervix(2)|endometrium(9)|kidney(12)|large_intestine(23)|liver(1)|lung(45)|ovary(2)|pancreas(1)|prostate(6)|skin(3)|stomach(1)|urinary_tract(8)	123		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		TTTTCGATCTGATCATGAAGT	0.393000			T	NTRK1	papillary thyroid								10	48					0	0	1	0	0
GTF2I	2969	broad.mit.edu	37	7	74119540	74119540	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr7:74119540C>G	ENST00000324896.4	+	7	1020	c.631C>G	c.(631-633)Cca>Gca	p.P211A	GTF2I_ENST00000443166.1_Missense_Mutation_p.P211A|AC083884.8_ENST00000450426.2_RNA|AC083884.8_ENST00000594967.1_RNA|GTF2I_ENST00000353920.4_Missense_Mutation_p.P211A|AC083884.8_ENST00000434256.1_RNA|GTF2I_ENST00000416070.1_Missense_Mutation_p.P211A|GTF2I_ENST00000346152.4_Missense_Mutation_p.P211A	NM_032999.2	NP_127492.1	P78347	GTF2I_HUMAN	general transcription factor IIi	211					negative regulation of angiogenesis|signal transduction|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(7)|kidney(1)|large_intestine(1)|lung(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	19						AATACTATCTCCAGGTGGAAG	0.318000													9	46					0	0	1	0	0
PARP1	142	broad.mit.edu	37	1	226566910	226566910	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:226566910C>G	ENST00000366794.5	-	12	1821	c.1678G>C	c.(1678-1680)Gtg>Ctg	p.V560L		NM_001618.3	NP_001609.2	P09874	PARP1_HUMAN	poly (ADP-ribose) polymerase 1	560					cellular response to insulin stimulus|protein ADP-ribosylation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nuclear envelope|nucleolus|transcription factor complex	DNA binding|identical protein binding|NAD+ ADP-ribosyltransferase activity|protein N-terminus binding|transcription factor binding|zinc ion binding			breast(2)|endometrium(4)|kidney(4)|large_intestine(8)|lung(15)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	44	Breast(184;0.133)			GBM - Glioblastoma multiforme(131;0.0531)		ACGATGTCCACCAGGCCAAGG	0.527000								Poly(ADP-ribose) polymerase (PARP) enzymes that bind to DNA					59	109					0	0	1	0	0
CHGB	1114	broad.mit.edu	37	20	5903125	5903125	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:5903125T>C	ENST00000378961.4	+	4	539	c.335T>C	c.(334-336)aTc>aCc	p.I112T		NM_001819.2	NP_001810.2	P05060	SCG1_HUMAN	chromogranin B (secretogranin 1)	112						extracellular region	hormone activity			breast(7)|kidney(2)|large_intestine(8)|lung(19)|ovary(1)|pancreas(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	47						GAGGAGGACATCCAAGGCCCA	0.602000													12	28					0	0	1	0	0
NFATC2	4773	broad.mit.edu	37	20	50140650	50140650	+	Splice_Site	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:50140650C>T	ENST00000371564.3	-	2	350		c.e2-1		NFATC2_ENST00000610033.1_Intron|NFATC2_ENST00000609943.1_Splice_Site|NFATC2_ENST00000609507.1_Intron|NFATC2_ENST00000414705.1_Splice_Site|NFATC2_ENST00000396009.3_Splice_Site	NM_001258296.1|NM_012340.4	NP_001245225.1|NP_036472.2	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2						B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity		EWSR1/NFATC2(9)	breast(2)|endometrium(7)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	53	Hepatocellular(150;0.248)					TTCGGCTCTTCTGGAAAGAGA	0.537000													13	32					0	0	1	0	0
ZMYND8	23613	broad.mit.edu	37	20	45905461	45905461	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:45905461G>C	ENST00000311275.7	-	11	1270	c.1017C>G	c.(1015-1017)ttC>ttG	p.F339L	ZMYND8_ENST00000446994.2_Missense_Mutation_p.F276L|ZMYND8_ENST00000471951.2_Missense_Mutation_p.F359L|ZMYND8_ENST00000396281.4_Missense_Mutation_p.F339L|ZMYND8_ENST00000458360.2_Missense_Mutation_p.F334L|ZMYND8_ENST00000372023.3_Missense_Mutation_p.F334L|ZMYND8_ENST00000540497.1_Missense_Mutation_p.F334L|ZMYND8_ENST00000262975.4_Missense_Mutation_p.F339L|ZMYND8_ENST00000360911.3_Missense_Mutation_p.F334L|ZMYND8_ENST00000468376.2_5'UTR|ZMYND8_ENST00000355972.4_Missense_Mutation_p.F339L|ZMYND8_ENST00000461685.1_Missense_Mutation_p.F359L|ZMYND8_ENST00000536340.1_Missense_Mutation_p.F366L|ZMYND8_ENST00000352431.2_Missense_Mutation_p.F359L	NM_001281772.1|NM_001281778.1|NM_001281783.1	NP_001268701.1|NP_001268707.1|NP_001268712.1	Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8	339							protein binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|prostate(3)|skin(2)|urinary_tract(8)	62			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			TGGCACTGTTGAAGATGCTCT	0.413000													19	116					0	0	1	0	0
MAP2	4133	broad.mit.edu	37	2	210558518	210558518	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:210558518G>T	ENST00000360351.4	+	7	2130	c.1624G>T	c.(1624-1626)Gat>Tat	p.D542Y	MAP2_ENST00000199940.6_Intron|MAP2_ENST00000392194.1_Intron|MAP2_ENST00000361559.4_Intron|MAP2_ENST00000447185.1_Missense_Mutation_p.D538Y	NM_002374.3	NP_002365.3	P11137	MAP2_HUMAN	microtubule-associated protein 2	542					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(36)|liver(2)|lung(42)|ovary(11)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	124		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	AATGAGAGTTGATGACAAAGA	0.383000													28	64					2.12542e-12	2.21931e-12	1	1	0
CYHR1	50626	broad.mit.edu	37	8	145689921	145689921	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr8:145689921G>A	ENST00000438911.2	-	2	301	c.168C>T	c.(166-168)agC>agT	p.S56S	CYHR1_ENST00000403000.2_Silent_p.S56S|CYHR1_ENST00000424149.2_Silent_p.S56S|CYHR1_ENST00000306145.5_Silent_p.S56S|CTD-2517M22.16_ENST00000525461.1_RNA	NM_138496.1	NP_612505.1	Q6ZMK1	CYHR1_HUMAN	cysteine/histidine-rich 1	56						perinuclear region of cytoplasm	zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|lung(3)|ovary(2)	7	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			CTTCGTGTGTGCTCAGCCCTG	0.637000													20	65					0	0	1	0	0
UIMC1	51720	broad.mit.edu	37	5	176396246	176396246	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:176396246G>C	ENST00000377219.2	-	6	676	c.510C>G	c.(508-510)atC>atG	p.I170M	UIMC1_ENST00000506128.1_Missense_Mutation_p.I170M|UIMC1_ENST00000511320.1_Missense_Mutation_p.I170M|UIMC1_ENST00000377227.4_Missense_Mutation_p.I170M	NM_016290.4	NP_057374.3	Q96RL1	UIMC1_HUMAN	ubiquitin interaction motif containing 1	170	Necessary for interaction with NR6A1 N- terminus.				double-strand break repair|G2/M transition DNA damage checkpoint|histone H2A K63-linked deubiquitination|negative regulation of transcription, DNA-dependent|positive regulation of DNA repair|response to ionizing radiation|transcription, DNA-dependent	BRCA1-A complex	histone binding|K63-linked polyubiquitin binding			NS(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(5)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	21	all_cancers(89;7.96e-05)|Renal(175;0.000269)|Lung NSC(126;0.00476)|all_lung(126;0.00806)	Medulloblastoma(196;0.0145)|all_neural(177;0.0325)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTCCCTGACTGATATGTGAGC	0.483000													9	107					0	0	1	0	0
NMBR	4829	broad.mit.edu	37	6	142409491	142409491	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:142409491G>C	ENST00000258042.1	-	1	445	c.305C>G	c.(304-306)tCg>tGg	p.S102W	RP11-137J7.2_ENST00000454401.1_RNA	NM_002511.2	NP_002502.2	P28336	NMBR_HUMAN	neuromedin B receptor	102					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	cytoplasm|integral to plasma membrane	bombesin receptor activity	p.S102W(1)|p.S102L(1)		breast(2)|central_nervous_system(3)|endometrium(3)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23	Breast(32;0.155)			OV - Ovarian serous cystadenocarcinoma(155;9.93e-06)|GBM - Glioblastoma multiforme(68;0.0013)		GAAGTAGCGCGAGGCGTCCAC	0.592000													15	23					0	0	1	0	0
ATP8B3	148229	broad.mit.edu	37	19	1785612	1785612	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:1785612G>A	ENST00000539485.1	-	26	3512	c.3279C>T	c.(3277-3279)atC>atT	p.I1093I	ATP8B3_ENST00000310127.6_Silent_p.I1083I|ATP8B3_ENST00000525591.1_Silent_p.I1046I			O60423	AT8B3_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 3	1083					ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	23		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CACCATGGGCGATGGCTTGGA	0.607000													6	10					0	0	1	0	0
THG1L	54974	broad.mit.edu	37	5	157161651	157161651	+	Missense_Mutation	SNP	G	G	A	rs78234336		TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:157161651G>A	ENST00000231198.7	+	3	680	c.436G>A	c.(436-438)Gag>Aag	p.E146K	AC026407.1_ENST00000599823.1_Silent_p.L25L	NM_017872.3	NP_060342.2	Q9NWX6	THG1_HUMAN	tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)	146					protein homotetramerization|tRNA modification	mitochondrion	GTP binding|metal ion binding|tRNA guanylyltransferase activity			NS(1)|central_nervous_system(2)|kidney(1)|large_intestine(1)|lung(5)|prostate(2)|skin(1)	13	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GGATTACTTTGAGGACCAGCC	0.502000													25	87					0	0	1	0	0
INPP5D	3635	broad.mit.edu	37	2	234102561	234102561	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:234102561G>C	ENST00000359570.5	+	25	2514	c.2514G>C	c.(2512-2514)gaG>gaC	p.E838D	INPP5D_ENST00000455936.2_Missense_Mutation_p.E602D|INPP5D_ENST00000450745.1_Missense_Mutation_p.E602D			Q92835	SHIP1_HUMAN	inositol polyphosphate-5-phosphatase, 145kDa	850					apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			central_nervous_system(1)|ovary(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		TCCAGGGGGAGATCAAGCTGC	0.617000													15	50					0	0	1	0	0
SLC28A3	64078	broad.mit.edu	37	9	86917179	86917179	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:86917179G>A	ENST00000376238.4	-	5	509	c.460C>T	c.(460-462)Cga>Tga	p.R154*	SLC28A3_ENST00000537648.1_Nonsense_Mutation_p.R85*	NM_001199633.1|NM_022127.2	NP_001186562.1|NP_071410.1	Q9HAS3	S28A3_HUMAN	solute carrier family 28 (concentrative nucleoside transporter), member 3	154					nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|plasma membrane	nucleoside binding	p.R154*(1)		endometrium(2)|large_intestine(6)|lung(17)|ovary(1)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31						TCATCAATTCGATGTTCGTAT	0.453000													21	45					0	0	1	0	0
CHIT1	1118	broad.mit.edu	37	1	203191375	203191375	+	Silent	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:203191375G>C	ENST00000367229.1	-	7	718	c.684C>G	c.(682-684)ctC>ctG	p.L228L	CHIT1_ENST00000535569.1_Silent_p.L219L|CHIT1_ENST00000255427.3_Silent_p.L209L|CHIT1_ENST00000484834.1_5'UTR	NM_001270509.1|NM_003465.2	NP_001257438.1|NP_003456.1	Q13231	CHIT1_HUMAN	chitinase 1 (chitotriosidase)	228					chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(1)|stomach(2)	27						GCCTCTTGTAGAGGGGGCTGT	0.577000													19	54					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3239744	3239744	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrX:3239744C>T	ENST00000217939.6	-	5	4136	c.3982G>A	c.(3982-3984)Gat>Aat	p.D1328N		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1328						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GCAACATCATCCTTAATTTCT	0.373000													39	34					0	0	1	0	0
B3GAT2	135152	broad.mit.edu	37	6	71665851	71665851	+	Missense_Mutation	SNP	C	C	G	rs9446312		TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:71665851C>G	ENST00000230053.6	-	1	890	c.282G>C	c.(280-282)caG>caC	p.Q94H		NM_080742.2	NP_542780.1	Q9NPZ5	B3GA2_HUMAN	beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)	94					carbohydrate biosynthetic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|metal ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(2)|urinary_tract(1)	16						GCTCCGCTTTCTGCACCGGGC	0.697000													18	32					0	0	1	0	0
ANKS1A	23294	broad.mit.edu	37	6	34985672	34985672	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:34985672G>A	ENST00000360359.3	+	11	1984	c.1846G>A	c.(1846-1848)Gaa>Aaa	p.E616K	ANKS1A_ENST00000535627.1_Intron	NM_015245.2	NP_056060.2	Q92625	ANS1A_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1A	616						cytoplasm	protein binding			cervix(2)|endometrium(3)|large_intestine(4)|lung(16)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31						ACCCAAAGCTGAACTCAAACT	0.582000													44	124					0	0	1	0	0
CEP152	22995	broad.mit.edu	37	15	49048212	49048212	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:49048212G>A	ENST00000380950.2	-	20	3420	c.3233C>T	c.(3232-3234)tCt>tTt	p.S1078F	CEP152_ENST00000399334.3_Missense_Mutation_p.S1078F|CEP152_ENST00000325747.5_Missense_Mutation_p.S985F	NM_001194998.1|NM_014985.3	NP_001181927.1|NP_055800.2	O94986	CE152_HUMAN	centrosomal protein 152kDa	1078					centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			breast(3)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(16)|lung(30)|ovary(1)|prostate(2)|skin(2)	63		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)		CCATTTTGAAGAACAAGTCGA	0.408000													41	99					0	0	1	0	0
DPY19L2P2	349152	broad.mit.edu	37	7	102825985	102825985	+	RNA	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr7:102825985C>T	ENST00000312132.4	-	0	3713																											AAGACAGCATCTGAAAAAAAA	0.353000													8	12					0	0	1	0	0
KCNIP2	30819	broad.mit.edu	37	10	103587660	103587660	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:103587660C>G	ENST00000358038.3	-	7	985	c.634G>C	c.(634-636)Gag>Cag	p.E212Q	KCNIP2_ENST00000355657.2_5'UTR|KCNIP2_ENST00000370046.1_Missense_Mutation_p.E144Q|KCNIP2_ENST00000343195.4_Missense_Mutation_p.E180Q|KCNIP2_ENST00000356640.2_Missense_Mutation_p.E230Q|KCNIP2_ENST00000461105.1_Missense_Mutation_p.E245Q|KCNIP2-AS1_ENST00000412353.1_RNA|KCNIP2_ENST00000353068.3_Missense_Mutation_p.E187Q|KCNIP2_ENST00000348850.5_Missense_Mutation_p.E185Q	NM_173192.2|NM_173193.2|NM_173195.2	NP_775284.1|NP_775285.1|NP_775287.1	Q9NS61	KCIP2_HUMAN	Kv channel interacting protein 2	230					clustering of voltage-gated potassium channels|detection of calcium ion|muscle contraction|regulation of heart contraction|signal transduction|synaptic transmission	cytoplasm|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|calcium ion binding|ER retention sequence binding|identical protein binding|protein N-terminus binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	11		Colorectal(252;0.122)		Epithelial(162;4.93e-09)|all cancers(201;2.63e-07)		AAGAAGCTCTCCACGTGTTCC	0.557000													15	58					0	0	1	0	0
ALPPL2	251	broad.mit.edu	37	2	233274450	233274450	+	Silent	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:233274450C>G	ENST00000295453.3	+	11	1519	c.1467C>G	c.(1465-1467)ccC>ccG	p.P489P		NM_031313.2	NP_112603.2	P10696	PPBN_HUMAN	alkaline phosphatase, placental-like 2	489					phosphorylation	anchored to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			breast(2)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|skin(1)	13		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)	Amifostine(DB01143)|Levamisole(DB00848)	GCCTGGAGCCCTACACCGCCT	0.741000													5	9					0	0	1	0	0
USP34	9736	broad.mit.edu	37	2	61622361	61622361	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:61622361G>A	ENST00000398571.2	-	4	636	c.560C>T	c.(559-561)tCa>tTa	p.S187L		NM_014709.3	NP_055524.3	Q70CQ2	UBP34_HUMAN	ubiquitin specific peptidase 34	187					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(14)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(52)|ovary(8)|prostate(10)|skin(6)|urinary_tract(2)	138			Epithelial(17;0.229)			TTCTTGAGTTGATATATCCTA	0.234000													13	21					0	0	1	0	0
FCHO1	23149	broad.mit.edu	37	19	17889421	17889421	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:17889421C>T	ENST00000594202.1	+	20	1634	c.1355C>T	c.(1354-1356)tCt>tTt	p.S452F	FCHO1_ENST00000595033.1_Missense_Mutation_p.S402F|FCHO1_ENST00000252771.7_Missense_Mutation_p.S452F|FCHO1_ENST00000600676.1_Missense_Mutation_p.S452F|FCHO1_ENST00000389133.4_Missense_Mutation_p.S452F|FCHO1_ENST00000596951.1_Missense_Mutation_p.S452F|FCHO1_ENST00000597512.1_Missense_Mutation_p.S459F|FCHO1_ENST00000596536.1_Missense_Mutation_p.S452F|FCHO1_ENST00000539407.1_Missense_Mutation_p.S452F	NM_001161357.1	NP_001154829.1	O14526	FCHO1_HUMAN	FCH domain only 1	452										NS(2)|breast(1)|large_intestine(6)|liver(1)|lung(12)	22						CCCCAAGGCTCTAGCAGCCTG	0.682000													3	2					0	0	1	0	0
KLF4	9314	broad.mit.edu	37	9	110250458	110250458	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:110250458C>T	ENST00000374672.4	-	3	690	c.217G>A	c.(217-219)Gac>Aac	p.D73N		NM_004235.4	NP_004226.3	O43474	KLF4_HUMAN	Kruppel-like factor 4 (gut)	73					fat cell differentiation|mesodermal cell fate determination|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|stem cell maintenance|transcription from RNA polymerase II promoter	nucleus	RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor recruiting transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(5)|large_intestine(1)|lung(3)|pancreas(1)|prostate(2)	16						CTCTCCAGGTCTGTGGCCACG	0.697000													5	20					0	0	1	0	0
STK24	8428	broad.mit.edu	37	13	99114081	99114081	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr13:99114081G>A	ENST00000397517.2	-	8	1076	c.1000C>T	c.(1000-1002)Ccc>Tcc	p.P334S	STK24_ENST00000539966.1_Missense_Mutation_p.P315S|STK24_ENST00000376547.3_Missense_Mutation_p.P346S	NM_001032296.2	NP_001027467.2	Q9Y6E0	STK24_HUMAN	serine/threonine kinase 24	346					cellular component disassembly involved in apoptosis|signal transduction	cytosol|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|ovary(1)|skin(1)	17	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			AGATTCTTGGGATCTTTTTCT	0.507000													33	74					0	0	1	0	0
ZMPSTE24	10269	broad.mit.edu	37	1	40737653	40737653	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:40737653G>A	ENST00000372759.3	+	6	880	c.715G>A	c.(715-717)Gaa>Aaa	p.E239K		NM_005857.4	NP_005848.2	O75844	FACE1_HUMAN	zinc metallopeptidase STE24	239						endoplasmic reticulum membrane|Golgi membrane|integral to membrane	metal ion binding|metalloexopeptidase activity			endometrium(3)|kidney(3)|large_intestine(4)|lung(4)|prostate(1)|skin(1)	16	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;6.3e-18)			AGAAGAAATTGAAGTAATGGC	0.373000													18	90					0	0	1	0	0
HAUS3	79441	broad.mit.edu	37	4	2238161	2238161	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr4:2238161C>G	ENST00000243706.4	-	4	1601	c.1372G>C	c.(1372-1374)Gag>Cag	p.E458Q	POLN_ENST00000511885.2_Intron|HAUS3_ENST00000506763.1_Missense_Mutation_p.E458Q|POLN_ENST00000515357.1_Intron|HAUS3_ENST00000443786.2_Missense_Mutation_p.E458Q	NM_024511.5	NP_078787.2	Q68CZ6	HAUS3_HUMAN	HAUS augmin-like complex, subunit 3	458					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle				breast(3)|endometrium(1)|large_intestine(7)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						TTCTTATTCTCTCCCTCCAAA	0.313000													22	33					0	0	1	0	0
KATNAL1	84056	broad.mit.edu	37	13	30782761	30782761	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr13:30782761C>T	ENST00000380615.3	-	11	1556	c.1389G>A	c.(1387-1389)ttG>ttA	p.L463L	KATNAL1_ENST00000380617.3_Silent_p.L463L	NM_032116.4	NP_115492.1	Q9BW62	KATL1_HUMAN	katanin p60 subunit A-like 1	463						cytoplasm|microtubule	ATP binding|microtubule-severing ATPase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|skin(1)|urinary_tract(3)	19		Lung SC(185;0.0257)		all cancers(112;0.114)|OV - Ovarian serous cystadenocarcinoma(117;0.213)		TCTTTAGGGCCAATTCAAAGT	0.418000													24	55					0	0	1	0	0
MARCH3	115123	broad.mit.edu	37	5	126214081	126214081	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:126214081C>T	ENST00000308660.5	-	4	913	c.399G>A	c.(397-399)ctG>ctA	p.L133L		NM_178450.3	NP_848545.1	Q86UD3	MARH3_HUMAN	membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase	133					endocytosis	cytoplasmic vesicle membrane|early endosome membrane|integral to membrane|lysosome	ligase activity|zinc ion binding			large_intestine(2)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	6		Prostate(80;0.0928)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.074)|OV - Ovarian serous cystadenocarcinoma(64;0.0793)		CAGGGTTTCTCAGCCACTGCC	0.547000													4	10					0	0	1	0	0
R3HCC1L	27291	broad.mit.edu	37	10	99969078	99969078	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:99969078G>C	ENST00000298999.3	+	5	1510	c.1207G>C	c.(1207-1209)Gat>Cat	p.D403H	R3HCC1L_ENST00000314594.5_5'UTR|R3HCC1L_ENST00000370584.3_Missense_Mutation_p.D403H|R3HCC1L_ENST00000370586.2_Intron	NM_014472.4	NP_055287			R3H domain and coiled-coil containing 1-like																		TAGAATAGCTGATGAGACCTC	0.398000													41	100					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10419630	10419630	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:10419630G>A	ENST00000226207.5	-	4	328	c.234C>T	c.(232-234)ttC>ttT	p.F78F	RP11-799N11.1_ENST00000399342.2_RNA|CTC-297N7.11_ENST00000587182.2_RNA|RP11-799N11.1_ENST00000581304.1_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	78	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						GGTTCATGGGGAAGACTTGGT	0.468000													16	129					0	0	1	0	0
SNX25	83891	broad.mit.edu	37	4	186185662	186185662	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr4:186185662C>G	ENST00000504273.1	+	4	604	c.310C>G	c.(310-312)Cta>Gta	p.L104V	SNX25_ENST00000264694.8_Missense_Mutation_p.L104V			Q9H3E2	SNX25_HUMAN	sorting nexin 25	104	PXA.				cell communication|protein transport	endosome membrane	phosphatidylinositol binding|signal transducer activity			NS(1)|breast(4)|endometrium(2)|kidney(4)|large_intestine(8)|lung(13)|ovary(2)|pancreas(2)|prostate(2)|urinary_tract(2)	40		all_lung(41;1.03e-13)|Lung NSC(41;2.5e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;2.13e-24)|Epithelial(43;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.6e-11)|BRCA - Breast invasive adenocarcinoma(30;0.00013)|Colorectal(24;0.000165)|GBM - Glioblastoma multiforme(59;0.000357)|COAD - Colon adenocarcinoma(29;0.000887)|STAD - Stomach adenocarcinoma(60;0.00118)|LUSC - Lung squamous cell carcinoma(40;0.0129)|READ - Rectum adenocarcinoma(43;0.228)		AGTAAGATTTCTACAAACGTG	0.413000													28	42					0	0	1	0	0
FMO3	2328	broad.mit.edu	37	1	171083364	171083364	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:171083364G>A	ENST00000367755.4	+	7	1156	c.1045G>A	c.(1045-1047)Gag>Aag	p.E349K	FMO3_ENST00000542847.1_Missense_Mutation_p.E329K|FMO3_ENST00000392085.2_Missense_Mutation_p.E349K|FMO3_ENST00000538429.1_Missense_Mutation_p.E286K	NM_001002294.2	NP_001002294.1	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	349					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			endometrium(1)|kidney(1)|large_intestine(12)|lung(12)|skin(1)|stomach(2)|urinary_tract(2)	31	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CAGAAACAATGAGATCATTTT	0.428000													26	59					0	0	1	0	0
MSR1	4481	broad.mit.edu	37	8	16026273	16026273	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr8:16026273C>T	ENST00000350896.3	-	4	521	c.324G>A	c.(322-324)atG>atA	p.M108I	MSR1_ENST00000355282.2_Missense_Mutation_p.M108I|MSR1_ENST00000445506.2_Missense_Mutation_p.M126I|MSR1_ENST00000262101.5_Missense_Mutation_p.M108I|MSR1_ENST00000536385.1_Intron|MSR1_ENST00000381998.4_Missense_Mutation_p.M108I	NM_138715.2|NM_138716.2	NP_619729.1|NP_619730.1	P21757	MSRE_HUMAN	macrophage scavenger receptor 1	108	Spacer (Probable).				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(7)|lung(14)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	37				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		CTTGAAATCTCATTTCCTCTT	0.403000													33	73					0	0	1	0	0
PIK3C2A	5286	broad.mit.edu	37	11	17112890	17112890	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:17112890G>A	ENST00000265970.7	-	31	4868	c.4869C>T	c.(4867-4869)ttC>ttT	p.F1623F	PIK3C2A_ENST00000531428.1_5'UTR|PIK3C2A_ENST00000540361.1_Silent_p.F1243F	NM_002645.2	NP_002636.2	O00443	P3C2A_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	1623	C2.				cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			central_nervous_system(4)|endometrium(5)|kidney(5)|large_intestine(7)|lung(24)|ovary(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	58					Phosphatidylserine(DB00144)	CCATTTCATTGAATGTCGGAT	0.328000													18	57					0	0	1	0	0
C12orf74	338809	broad.mit.edu	37	12	93100662	93100662	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:93100662G>A	ENST00000544406.2	+	2	521	c.255G>A	c.(253-255)tcG>tcA	p.S85S	C12orf74_ENST00000397833.3_Silent_p.S85S			Q32Q52	CL074_HUMAN	chromosome 12 open reading frame 74	85								p.S85S(1)		kidney(1)|large_intestine(2)|lung(4)|prostate(1)|urinary_tract(2)	10						GTTACCTTTCGAAGAGCCTGC	0.567000													14	41					0	0	1	0	0
BAI3	577	broad.mit.edu	37	6	69640534	69640534	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:69640534G>A	ENST00000370598.1	+	4	1662	c.841G>A	c.(841-843)Gat>Aat	p.D281N		NM_001704.2	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	281					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				GGAACAAGCTGATGCTGCTAA	0.333000													10	31					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39824382	39824382	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:39824382G>C	ENST00000564288.1	+	46	12734	c.11957G>C	c.(11956-11958)gGa>gCa	p.G3986A	MACF1_ENST00000372915.3_Missense_Mutation_p.G3991A|MACF1_ENST00000289893.4_Missense_Mutation_p.G2426A|MACF1_ENST00000476350.1_3'UTR|MACF1_ENST00000567887.1_Missense_Mutation_p.G4023A|MACF1_ENST00000317713.7_Missense_Mutation_p.G1924A|MACF1_ENST00000545844.1_Missense_Mutation_p.G1924A|MACF1_ENST00000361689.2_Missense_Mutation_p.G1924A|MACF1_ENST00000539005.1_Missense_Mutation_p.G1924A			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	3991					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			ACACGATTAGGATCTCACCTG	0.502000													16	38					0	0	1	0	0
RPA1	6117	broad.mit.edu	37	17	1747276	1747276	+	Silent	SNP	A	A	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:1747276A>T	ENST00000254719.5	+	3	257	c.147A>T	c.(145-147)ggA>ggT	p.G49G		NM_002945.3	NP_002936.1	P27694	RFA1_HUMAN	replication protein A1, 70kDa	49					cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	actin cytoskeleton|cytoplasm|DNA replication factor A complex|PML body	metal ion binding|protein binding|single-stranded DNA binding			breast(1)|endometrium(3)|large_intestine(2)|lung(2)|ovary(2)	10						TGAGTGATGGATTGAACACTC	0.443000								Nucleotide excision repair (NER)					10	43					0	0	1	0	0
CAPN3	825	broad.mit.edu	37	15	42703108	42703108	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:42703108G>C	ENST00000397163.3	+	22	2509	c.2290G>C	c.(2290-2292)Gac>Cac	p.D764H	CAPN3_ENST00000318023.7_Missense_Mutation_p.D758H|CAPN3_ENST00000337571.4_Missense_Mutation_p.D99H|RP11-164J13.1_ENST00000495723.1_RNA|CAPN3_ENST00000397200.4_Missense_Mutation_p.D252H|CAPN3_ENST00000357568.3_Missense_Mutation_p.D758H|CAPN3_ENST00000356316.3_Missense_Mutation_p.D671H|CAPN3_ENST00000397204.4_Missense_Mutation_p.D99H|CAPN3_ENST00000569136.1_Missense_Mutation_p.D99H|CAPN3_ENST00000349748.3_Missense_Mutation_p.D672H|CAPN3_ENST00000561817.1_Missense_Mutation_p.D99H|CAPN3_ENST00000562199.1_3'UTR	NM_000070.2	NP_000061.1	P20807	CAN3_HUMAN	calpain 3, (p94)	764	Domain IV.				muscle organ development|proteolysis	cytoplasm	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(21)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	47		all_cancers(109;1.65e-16)|all_epithelial(112;8.34e-15)|Lung NSC(122;3.56e-09)|all_lung(180;1.68e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;7.36e-07)		CCAGCTCTATGACATCATTAC	0.517000													20	49					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166243479	166243479	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:166243479T>C	ENST00000357398.3	+	26	5065	c.4775T>C	c.(4774-4776)aTt>aCt	p.I1592T	SCN2A_ENST00000283256.6_Missense_Mutation_p.I1592T|SCN2A_ENST00000375427.2_Missense_Mutation_p.I1592T|SCN2A_ENST00000375437.2_Missense_Mutation_p.I1592T			Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	1592					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	TATTTCACTATTGGATGGAAT	0.343000													18	72					0	0	1	0	0
CDH9	1007	broad.mit.edu	37	5	26890543	26890543	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:26890543C>T	ENST00000231021.4	-	8	1556	c.1384G>A	c.(1384-1386)Gaa>Aaa	p.E462K		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	462	Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.E462*(1)		breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						TTACTTATTTCTGTGGCTGTA	0.393000													21	126					0	0	1	0	0
POLR3E	55718	broad.mit.edu	37	16	22319516	22319516	+	Silent	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr16:22319516C>G	ENST00000299853.5	+	4	302	c.135C>G	c.(133-135)ctC>ctG	p.L45L	POLR3E_ENST00000564209.1_Silent_p.L45L|POLR3E_ENST00000564256.1_3'UTR|POLR3E_ENST00000359210.4_Silent_p.L45L|POLR3E_ENST00000418581.2_Intron	NM_001258033.1|NM_001258035.1|NM_018119.3	NP_001244962.1|NP_001244964.1|NP_060589.1	Q9NVU0	RPC5_HUMAN	polymerase (RNA) III (DNA directed) polypeptide E (80kD)	45					innate immune response|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA-directed RNA polymerase activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27				GBM - Glioblastoma multiforme(48;0.012)		TTCCGCACCTCTCAGCCAAGA	0.627000													10	43					0	0	1	0	0
PRKD3	23683	broad.mit.edu	37	2	37513484	37513484	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:37513484delC	ENST00000379066.1	-	6	1508	c.746delG	c.(745-747)agafs	p.R249fs	PRKD3_ENST00000234179.2_Frame_Shift_Del_p.R249fs			O94806	KPCD3_HUMAN	protein kinase D3	249					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			breast(3)|central_nervous_system(2)|kidney(3)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33		all_hematologic(82;0.21)				AGAAGGAATTCTCTTACTTGG	0.418													15	52	---	---	---	---					
LINC00518	221718	broad.mit.edu	37	6	10430699	10430699	+	RNA	DEL	T	T	-	rs79230388		TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:10430699delT	ENST00000496285.1	-	0	489					NR_027793.1																						CTCTGACTAGttttttttttt	0.453													2	4	---	---	---	---					
CDKN1A	1026	broad.mit.edu	37	6	36652198	36652199	+	Frame_Shift_Ins	INS	-	-	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:36652198_36652199insG	ENST00000405375.1	+	2	555_556	c.320_321insG	c.(319-324)gaggaafs	p.E108fs	CDKN1A_ENST00000244741.5_Frame_Shift_Ins_p.E108fs|CDKN1A_ENST00000373711.2_Frame_Shift_Ins_p.E108fs|CDKN1A_ENST00000478800.1_3'UTR|CDKN1A_ENST00000448526.2_Frame_Shift_Ins_p.E142fs	NM_001220778.1	NP_001207707.1	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	108					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|urinary_tract(5)	15						GGGACAGCAGAGGAAGACCATG	0.653													8	19	---	---	---	---					
LY96	23643	broad.mit.edu	37	8	74903693	74903693	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr8:74903693delT	ENST00000284818.2	+	1	107	c.16delT	c.(16-18)tttfs	p.F7fs	LY96_ENST00000518893.1_Frame_Shift_Del_p.F7fs	NM_015364.4	NP_056179	Q9Y6Y9	LY96_HUMAN	lymphocyte antigen 96	7					cellular defense response|detection of lipopolysaccharide|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	extracellular space|lipopolysaccharide receptor complex|plasma membrane	coreceptor activity|lipopolysaccharide receptor activity|protein binding			endometrium(1)|large_intestine(2)|lung(1)|upper_aerodigestive_tract(1)	5	Breast(64;0.0311)		Epithelial(68;0.0208)|BRCA - Breast invasive adenocarcinoma(89;0.0499)|all cancers(69;0.0619)			ACCATTTCTGTTTTTTTCCAC	0.368													23	75	---	---	---	---					
RAD23B	5887	broad.mit.edu	37	9	110062443	110062451	+	In_Frame_Del	DEL	ATTGAATCT	ATTGAATCT	-			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:110062443_110062451delATTGAATCT	ENST00000358015.3	+	2	439_447	c.88_96delATTGAATCT	c.(88-96)attgaatctdel	p.IES30del	RAD23B_ENST00000416373.2_De_novo_Start_InFrame	NM_001244713.1|NM_002874.4	NP_001231642.1|NP_002865.1	P54727	RD23B_HUMAN	RAD23 homolog B (S. cerevisiae)	30	Ubiquitin-like.				nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|nucleoplasm|proteasome complex|XPC complex	damaged DNA binding|polyubiquitin binding|single-stranded DNA binding			breast(3)|cervix(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14						GAAAGAGAAGATTGAATCTGAAAAGGGGA	0.287								Direct reversal of damage;Nucleotide excision repair (NER)					16	55	---	---	---	---					
EP300	2033	broad.mit.edu	37	22	41564578	41564580	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr22:41564578_41564580delGAA	ENST00000263253.7	+	24	5219_5221	c.4000_4002delGAA	c.(4000-4002)gaadel	p.E1334del		NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	1334					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						CAAAACCGTGGAAGTAAAACCAG	0.429			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				15	49	---	---	---	---