Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZNF85	7639	broad.mit.edu	37	19	21133034	21133034	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr19:21133034G>C	ENST00000601023.1	+	2	2183	c.1537G>C	c.(1537-1539)Gac>Cac	p.D513H	ZNF85_ENST00000328178.8_Missense_Mutation_p.D572H|ZNF85_ENST00000345030.6_Missense_Mutation_p.D539H			Q03923	ZNF85_HUMAN	zinc finger protein 85	572						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)	20						TGAAGAATGTGACAAAGCTTT	0.323000													3	5					0	0	1	0	0
ADAM30	11085	broad.mit.edu	37	1	120438559	120438559	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr1:120438559C>T	ENST00000369400.1	-	1	559	c.401G>A	c.(400-402)cGa>cAa	p.R134Q		NM_021794.3	NP_068566.2	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30	134					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(16)|ovary(2)|skin(2)	38	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		AAATACACCTCGGAGACCCCC	0.458000													32	26					0	0	1	0	0
FUK	197258	broad.mit.edu	37	16	70504275	70504275	+	Silent	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr16:70504275C>G	ENST00000288078.6	+	11	1246	c.1014C>G	c.(1012-1014)ctC>ctG	p.L338L	FUK_ENST00000571514.1_5'UTR|FUK_ENST00000378912.2_Silent_p.L370L	NM_145059.2	NP_659496.2	Q8N0W3	FUK_HUMAN	fucokinase	338						cytoplasm	ATP binding|fucokinase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(11)|ovary(2)|prostate(2)	23		Ovarian(137;0.0694)				AGTTCCTGCTCAGCCTCACAC	0.612000													64	55					0	0	1	0	0
SLC22A10	387775	broad.mit.edu	37	11	63069887	63069887	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr11:63069887G>A	ENST00000332793.6	+	7	1159	c.1157G>A	c.(1156-1158)gGa>gAa	p.G386E	SLC22A10_ENST00000526800.1_Intron|SLC22A10_ENST00000525620.1_Intron|SLC22A10_ENST00000535888.1_Intron|SLC22A10_ENST00000544661.1_Intron	NM_001039752.3	NP_001034841.3	Q63ZE4	S22AA_HUMAN	solute carrier family 22, member 10	386						integral to membrane	transmembrane transporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						GTACTTTATGGAGCTGTCGCT	0.433000													26	13					0	0	1	0	0
DCBLD1	285761	broad.mit.edu	37	6	117861961	117861961	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr6:117861961G>C	ENST00000338728.5	+	10	1352	c.1232G>C	c.(1231-1233)gGt>gCt	p.G411A	DCBLD1_ENST00000296955.8_Missense_Mutation_p.G411A|DCBLD1_ENST00000368503.4_Intron|GOPC_ENST00000467125.1_Intron|DCBLD1_ENST00000534777.1_3'UTR			Q8N8Z6	DCBD1_HUMAN	discoidin, CUB and LCCL domain containing 1	411	F5/8 type C.				cell adhesion	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(15)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	26		all_cancers(87;0.171)		GBM - Glioblastoma multiforme(226;0.0447)|OV - Ovarian serous cystadenocarcinoma(136;0.0921)|all cancers(137;0.125)		GAGCTCATTGGTTGCCAGATT	0.488000													12	63					0	0	1	0	0
KCND1	3750	broad.mit.edu	37	X	48820025	48820025	+	Silent	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chrX:48820025C>T	ENST00000218176.3	-	6	3058	c.1761G>A	c.(1759-1761)ctG>ctA	p.L587L	KCND1_ENST00000376477.1_Silent_p.L210L	NM_004979.4	NP_004970.3	Q9NSA2	KCND1_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 1	587						voltage-gated potassium channel complex	metal ion binding|voltage-gated potassium channel activity			endometrium(3)|large_intestine(7)|lung(7)|ovary(2)|prostate(1)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	24						TGTCGCAGTTCAGGTCAAGGC	0.592000													9	5					0	0	1	0	0
CEP68	23177	broad.mit.edu	37	2	65299128	65299128	+	Nonsense_Mutation	SNP	G	G	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr2:65299128G>T	ENST00000377990.2	+	3	1101	c.898G>T	c.(898-900)Gaa>Taa	p.E300*	CEP68_ENST00000546106.1_Nonsense_Mutation_p.E300*|CEP68_ENST00000260569.4_Nonsense_Mutation_p.E300*|CEP68_ENST00000497039.1_3'UTR|RAB1A_ENST00000494188.1_Intron|CEP68_ENST00000537589.1_5'UTR	NM_015147.2	NP_055962.2	Q76N32	CEP68_HUMAN	centrosomal protein 68kDa	300					centrosome organization	centrosome				breast(1)|endometrium(6)|kidney(8)|large_intestine(5)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32						TAAAGAGTATGAAGATCTGCT	0.587000													53	28					5.82089e-37	6.90091e-37	1	1	0
RIN1	9610	broad.mit.edu	37	11	66100202	66100202	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr11:66100202G>C	ENST00000311320.4	-	10	2023	c.1897C>G	c.(1897-1899)Cag>Gag	p.Q633E	RIN1_ENST00000424433.2_Missense_Mutation_p.Q528E|RIN1_ENST00000530056.1_Missense_Mutation_p.Q467E|RIN1_ENST00000524804.1_5'UTR	NM_004292.2	NP_004283.2	Q13671	RIN1_HUMAN	Ras and Rab interactor 1	633	Ras and 14-3-3 protein binding region.|Ras-associating.				endocytosis|signal transduction	cytoplasm|cytoskeleton|plasma membrane	GTPase activator activity|protein binding			breast(1)|central_nervous_system(3)|haematopoietic_and_lymphoid_tissue(1)|lung(8)|ovary(1)	14						CTGGGATCCTGATAGGCTACT	0.582000													26	38					0	0	1	0	0
GEMIN5	25929	broad.mit.edu	37	5	154284069	154284069	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr5:154284069C>T	ENST00000285873.7	-	18	2705	c.2630G>A	c.(2629-2631)aGa>aAa	p.R877K		NM_001252156.1|NM_015465.4	NP_001239085.1|NP_056280.2	Q8TEQ6	GEMI5_HUMAN	gem (nuclear organelle) associated protein 5	877					ncRNA metabolic process|protein complex assembly|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding|snRNA binding			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TTTTGTACCTCTGGAGTGCTT	0.438000													35	12					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76430220	76430220	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr17:76430220C>G	ENST00000389840.5	-	75	12221	c.12097G>C	c.(12097-12099)Gag>Cag	p.E4033Q	DNAH17_ENST00000585328.1_Missense_Mutation_p.E4034Q|DNAH17_ENST00000586052.1_5'UTR					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TTGCGCCTCTCTGCCACCACA	0.607000													33	63					0	0	1	0	0
ATP6V1B1	525	broad.mit.edu	37	2	71190301	71190301	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr2:71190301G>C	ENST00000234396.4	+	10	992	c.919G>C	c.(919-921)Gct>Cct	p.A307P	AC007040.11_ENST00000606025.1_Intron|ATP6V1B1_ENST00000412314.1_Missense_Mutation_p.A307P	NM_001692.3	NP_001683.2	P15313	VATB1_HUMAN	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1	307					ATP hydrolysis coupled proton transport|calcium ion homeostasis|cellular iron ion homeostasis|excretion|inner ear morphogenesis|insulin receptor signaling pathway|ossification|pH reduction|sensory perception of sound|transferrin transport	apical plasma membrane|basolateral plasma membrane|cytosol|endomembrane system|lateral plasma membrane|microvillus|proton-transporting V-type ATPase, V1 domain|vacuolar proton-transporting V-type ATPase complex	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(5)|prostate(1)|skin(1)	19						GGTCTCTGCTGCTAGAGAGGA	0.602000													42	18					0	0	1	0	0
CACNB2	783	broad.mit.edu	37	10	18789796	18789796	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr10:18789796G>A	ENST00000396576.2	+	4	848	c.347G>A	c.(346-348)gGa>gAa	p.G116E	CACNB2_ENST00000324631.7_Missense_Mutation_p.G171E|CACNB2_ENST00000377328.1_Intron|CACNB2_ENST00000282343.8_Missense_Mutation_p.G143E|CACNB2_ENST00000352115.6_Missense_Mutation_p.G171E|CACNB2_ENST00000377331.2_Missense_Mutation_p.G143E|CACNB2_ENST00000377329.4_Missense_Mutation_p.G117E|CACNB2_ENST00000377319.3_Missense_Mutation_p.G116E|CACNB2_ENST00000377315.4_Missense_Mutation_p.G123E	NM_000724.3	NP_000715.2	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2 subunit	171	SH3.				axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(12)|prostate(1)|skin(3)|stomach(2)	31					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TGTGAAATCGGATTCATTCCA	0.413000													7	27					0	0	1	0	0
OR8B2	26595	broad.mit.edu	37	11	124252330	124252330	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr11:124252330G>C	ENST00000375013.2	-	1	928	c.910C>G	c.(910-912)Ctg>Gtg	p.L304V		NM_001005468.1	NP_001005468.1	Q96RD0	OR8B2_HUMAN	olfactory receptor, family 8, subfamily B, member 2	304					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(13)|ovary(1)	23		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		ATTTTAATCAGAGCTTTCCTC	0.338000													18	13					0	0	1	0	0
TRPA1	8989	broad.mit.edu	37	8	72945901	72945901	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr8:72945901G>C	ENST00000262209.4	-	23	3053	c.2846C>G	c.(2845-2847)cCa>cGa	p.P949R	RP11-383H13.1_ENST00000537896.1_Intron|RP11-383H13.1_ENST00000524152.1_Intron|RP11-383H13.1_ENST00000457356.4_Intron	NM_007332.2	NP_015628.2	O75762	TRPA1_HUMAN	transient receptor potential cation channel, subfamily A, member 1	949						integral to plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(26)|lung(44)|ovary(4)|prostate(6)|stomach(1)	98			Epithelial(68;0.223)		Menthol(DB00825)	GAGGACAATTGGGACAAATAT	0.303000													13	7					0	0	1	0	0
MGRN1	23295	broad.mit.edu	37	16	4733904	4733904	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr16:4733904G>A	ENST00000399577.5	+	16	1682	c.1589G>A	c.(1588-1590)cGa>cAa	p.R530Q	MGRN1_ENST00000588994.1_Missense_Mutation_p.R508Q|MGRN1_ENST00000262370.7_Missense_Mutation_p.R530Q|MGRN1_ENST00000586183.1_Missense_Mutation_p.R508Q|MGRN1_ENST00000415496.1_Missense_Mutation_p.R509Q	NM_001142290.2	NP_001135762.1	O60291	MGRN1_HUMAN	mahogunin ring finger 1, E3 ubiquitin protein ligase	530					endosome to lysosome transport|negative regulation of cAMP-mediated signaling|negative regulation of G-protein coupled receptor protein signaling pathway|protein monoubiquitination	cytosol|early endosome|nucleus|plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	18						CACTGTGGCCGAGGCCCACCT	0.662000													4	12					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110523074	110523074	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr8:110523074G>A	ENST00000378402.5	+	71	11568	c.11464G>A	c.(11464-11466)Gtg>Atg	p.V3822M		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	3822					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TCACAGCATTGTGGCTCTGAA	0.448000										HNSCC(38;0.096)			32	119					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176526036	176526036	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr1:176526036C>T	ENST00000367662.3	+	2	1742	c.578C>T	c.(577-579)gCc>gTc	p.A193V	PAPPA2_ENST00000367661.3_Missense_Mutation_p.A193V	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	193					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						AGGGGCTGGGCCAAGTCCAGG	0.587000													13	160					0	0	1	0	0
AP3B1	8546	broad.mit.edu	37	5	77298814	77298814	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr5:77298814G>C	ENST00000255194.6	-	27	3372	c.3197C>G	c.(3196-3198)tCt>tGt	p.S1066C	AP3B1_ENST00000519295.1_Missense_Mutation_p.S1017C	NM_001271769.1	NP_001258698.1	O00203	AP3B1_HUMAN	adaptor-related protein complex 3, beta 1 subunit	1066					endocytosis|melanosome organization	clathrin coated vesicle membrane|Golgi apparatus|membrane coat	protein phosphatase binding|protein transporter activity			breast(5)|central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(12)|lung(12)|prostate(1)|skin(2)|urinary_tract(1)	39		all_lung(232;0.000397)|Lung NSC(167;0.00106)|Ovarian(174;0.0105)|Prostate(461;0.215)		OV - Ovarian serous cystadenocarcinoma(54;8.23e-47)|Epithelial(54;2.74e-41)|all cancers(79;4.8e-36)		CTGGGCTGTAGAGCCTTCCTT	0.463000									Hermansky-Pudlak syndrome				13	39					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100683865	100683865	+	Silent	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr7:100683865G>C	ENST00000306151.4	+	3	9232	c.9168G>C	c.(9166-9168)acG>acC	p.T3056T		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	3056	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					TCAGCACCACGCCAGTGGCCA	0.493000													42	320					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24884118	24884118	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr14:24884118G>C	ENST00000382554.3	+	9	3481	c.3163G>C	c.(3163-3165)Gac>Cac	p.D1055H		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	1055					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						CCTGGACATCGACCTCCTGCC	0.652000													15	21					0	0	1	0	0
PLG	5340	broad.mit.edu	37	6	161139345	161139345	+	Silent	SNP	T	T	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr6:161139345T>A	ENST00000308192.9	+	8	870	c.807T>A	c.(805-807)tcT>tcA	p.S269S		NM_000301.3	NP_000292.1	P00747	PLMN_HUMAN	plasminogen	269					extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)	59				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	CACCATCTTCTGGTCCCACCT	0.502000													6	45					0	0	1	0	0
CSNK1G2	1455	broad.mit.edu	37	19	1978612	1978612	+	Nonsense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr19:1978612C>T	ENST00000255641.8	+	5	805	c.310C>T	c.(310-312)Cag>Tag	p.Q104*		NM_001319.6	NP_001310.3	P78368	KC1G2_HUMAN	casein kinase 1, gamma 2	104	Protein kinase.				sphingolipid metabolic process|Wnt receptor signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity			endometrium(1)|kidney(1)|lung(3)|prostate(1)|skin(1)|stomach(1)	8		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGCGTCCCTCAGGTCTACTA	0.726000													3	6					0	0	1	0	0
NETO1	81832	broad.mit.edu	37	18	70532143	70532143	+	Missense_Mutation	SNP	C	C	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr18:70532143C>A	ENST00000327305.6	-	3	777	c.120G>T	c.(118-120)caG>caT	p.Q40H	NETO1_ENST00000397929.1_Missense_Mutation_p.Q39H|NETO1_ENST00000583169.1_Missense_Mutation_p.Q40H|NETO1_ENST00000580049.1_5'UTR|NETO1_ENST00000299430.2_Missense_Mutation_p.Q39H	NM_138966.3	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin (NRP) and tolloid (TLL)-like 1	40					memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			NS(3)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(36)|ovary(2)|prostate(3)|skin(3)|stomach(1)	63		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		AAGTTCCACACTGCACTGACT	0.388000													4	16					0.184627	0.185003	1	1	0
IGLV5-48	28780	broad.mit.edu	37	22	22707587	22707587	+	RNA	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr22:22707587C>T	ENST00000390293.1	+	0	175																											CTGGTACCAGCAGAAGCCAGA	0.552000													9	55					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94544953	94544953	+	Silent	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr1:94544953C>T	ENST00000370225.3	-	9	1250	c.1164G>A	c.(1162-1164)agG>agA	p.R388R	ABCA4_ENST00000535735.1_Silent_p.R388R	NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	388					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		GCTTTGCCGCCCTCCAAGCGA	0.473000													8	43					0	0	1	0	0
JARID2	3720	broad.mit.edu	37	6	15507590	15507590	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr6:15507590C>T	ENST00000341776.2	+	11	2918	c.2674C>T	c.(2674-2676)Ctc>Ttc	p.L892F	JARID2_ENST00000397311.3_Missense_Mutation_p.L720F|JARID2_ENST00000541660.1_Missense_Mutation_p.L854F|JARID2_ENST00000474854.1_3'UTR	NM_004973.3	NP_004964.2	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2	892	JmjC.				central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	59	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				TGGATGGAACCTCACCGTCCT	0.592000													13	87					0	0	1	0	0
CDC14A	8556	broad.mit.edu	37	1	100949903	100949903	+	Nonsense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr1:100949903C>T	ENST00000336454.3	+	11	1388	c.1033C>T	c.(1033-1035)Cga>Tga	p.R345*	RP5-837M10.4_ENST00000432210.1_RNA|CDC14A_ENST00000542213.1_Nonsense_Mutation_p.R287*|CDC14A_ENST00000370125.2_3'UTR|CDC14A_ENST00000370124.3_Nonsense_Mutation_p.R345*|CDC14A_ENST00000544534.1_Nonsense_Mutation_p.R345*|CDC14A_ENST00000361544.6_Nonsense_Mutation_p.R345*	NM_003672.3	NP_003663.2	Q9UNH5	CC14A_HUMAN	cell division cycle 14A	345			R -> Q (in dbSNP:rs28364897).		cell cycle|cell division|cell proliferation	centrosome|nucleus|spindle	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(1)|endometrium(5)|kidney(6)|large_intestine(6)|lung(10)|skin(2)|urinary_tract(1)	31		all_epithelial(167;3.71e-06)|all_lung(203;0.00097)|Lung NSC(277;0.001)		Epithelial(280;0.0676)|all cancers(265;0.127)|COAD - Colon adenocarcinoma(174;0.201)|Lung(183;0.227)|Colorectal(144;0.241)		ACTGAAAAATCGACCATCCAG	0.343000													9	9					0	0	1	0	0
RAB3IL1	5866	broad.mit.edu	37	11	61665787	61665787	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr11:61665787G>A	ENST00000394836.2	-	10	1269	c.1112C>T	c.(1111-1113)tCa>tTa	p.S371L	RAB3IL1_ENST00000301773.5_Missense_Mutation_p.S345L	NM_013401.2	NP_037533.2	Q8TBN0	R3GEF_HUMAN	RAB3A interacting protein (rabin3)-like 1	371							protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|liver(1)|lung(4)|skin(3)|urinary_tract(1)	14						CTTGGCCAGTGACATCTCCTT	0.627000											OREG0021017	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	96	59					0	0	1	0	0
COLGALT1	79709	broad.mit.edu	37	19	17690356	17690356	+	Silent	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr19:17690356C>T	ENST00000252599.4	+	10	1452	c.1332C>T	c.(1330-1332)ttC>ttT	p.F444F		NM_024656.2	NP_078932.2			collagen beta(1-O)galactosyltransferase 1																		AGATCTTCTTCAAGAGACGTC	0.602000													25	49					0	0	1	0	0
PRPF40B	25766	broad.mit.edu	37	12	50027715	50027715	+	Missense_Mutation	SNP	C	C	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr12:50027715C>A	ENST00000261897.1	+	9	1119	c.568C>A	c.(568-570)Cag>Aag	p.Q190K	PRPF40B_ENST00000548825.2_Missense_Mutation_p.Q218K|PRPF40B_ENST00000380281.1_Missense_Mutation_p.Q196K			Q6NWY9	PR40B_HUMAN	PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)	196					mRNA processing|RNA splicing	nuclear speck				breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	34						ACAGCCACCTCAGCCACAGCC	0.612000													17	115					5.35267e-07	5.78794e-07	1	1	0
RNF13	11342	broad.mit.edu	37	3	149619893	149619893	+	Silent	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr3:149619893C>T	ENST00000344229.3	+	7	1146	c.444C>T	c.(442-444)gtC>gtT	p.V148V	RNF13_ENST00000361785.6_Silent_p.V29V|RNF13_ENST00000392894.3_Silent_p.V148V	NM_007282.4	NP_009213.1	O43567	RNF13_HUMAN	ring finger protein 13	148	PA.				protein autoubiquitination	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane|nuclear inner membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|skin(2)	11		all_neural(597;0.0138)|Myeloproliferative disorder(1037;0.0255)	LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			TTCCATCTGTCTTTATTGGTG	0.269000													22	16					0	0	1	0	0
HLA-DQB2	3120	broad.mit.edu	37	6	32725567	32725567	+	Missense_Mutation	SNP	C	C	T	rs114234640	byFrequency	TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr6:32725567C>T	ENST00000435145.2	-	4	801	c.740G>A	c.(739-741)cGt>cAt	p.R247H	HLA-DQB2_ENST00000411527.1_Intron|HLA-DQB2_ENST00000437316.2_Missense_Mutation_p.R247H			Q5SR06	Q5SR06_HUMAN	major histocompatibility complex, class II, DQ beta 2	216					antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|immune response	integral to membrane|MHC class II protein complex				endometrium(1)|kidney(1)|lung(1)|prostate(2)	5						ACCCCTGTGACGGATGATAAG	0.552000													7	23					0	0	1	0	0
PAK7	57144	broad.mit.edu	37	20	9561495	9561495	+	Missense_Mutation	SNP	C	C	A	rs146341429		TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr20:9561495C>A	ENST00000378429.3	-	5	833	c.287G>T	c.(286-288)cGc>cTc	p.R96L	PAK7_ENST00000353224.5_Missense_Mutation_p.R96L|PAK7_ENST00000378423.1_Missense_Mutation_p.R96L	NM_020341.3	NP_065074.1	Q9P286	PAK7_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 7	96	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(44)|ovary(2)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)	81			COAD - Colon adenocarcinoma(9;0.194)			GGAGTTGGAGCGAGTCACCGA	0.532000													35	82					1.45844e-13	1.68835e-13	1	1	0
ZNF783	100289678	broad.mit.edu	37	7	148978876	148978876	+	Silent	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr7:148978876G>A	ENST00000434415.1	+	6	1246	c.1083G>A	c.(1081-1083)aaG>aaA	p.K361K	ZNF783_ENST00000489518.1_Intron	NM_001195220.1	NP_001182149.1	C9J9J2	C9J9J2_HUMAN	zinc finger family member 783	361					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|prostate(1)	22	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.0014)			TCCGCCTGAAGATCAATCTGA	0.721000													3	7					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152520102	152520102	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr2:152520102C>T	ENST00000397345.3	-	45	5925	c.5723G>A	c.(5722-5724)aGc>aAc	p.S1908N	NEB_ENST00000604864.1_Missense_Mutation_p.S1908N|NEB_ENST00000172853.10_Missense_Mutation_p.S1908N|NEB_ENST00000603639.1_Missense_Mutation_p.S1908N|NEB_ENST00000427231.2_Missense_Mutation_p.S1908N|NEB_ENST00000409198.1_Missense_Mutation_p.S1908N	NM_001164508.1	NP_001157980	P20929	NEBU_HUMAN	nebulin	1908					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		CAATTCAAAGCTCATGGCATC	0.453000													4	61					0	0	1	0	0
KRT79	338785	broad.mit.edu	37	12	53227682	53227682	+	Silent	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr12:53227682C>T	ENST00000330553.5	-	1	397	c.363G>A	c.(361-363)caG>caA	p.Q121Q		NM_175834.2	NP_787028.1	Q5XKE5	K2C79_HUMAN	keratin 79	121	Head.					keratin filament	structural molecule activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						TCAGCAGGCTCTGGTTGACAG	0.607000													37	27					0	0	1	0	0
GBAP1	2630	broad.mit.edu	37	1	155187164	155187164	+	RNA	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr1:155187164C>G	ENST00000486869.1	-	0	349					NR_002188.2																						ATATCCGATTCCTACAGAAAA	0.483000													25	27					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82581272	82581272	+	Missense_Mutation	SNP	T	T	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr7:82581272T>G	ENST00000333891.9	-	5	9334	c.8997A>C	c.(8995-8997)ttA>ttC	p.L2999F	PCLO_ENST00000423517.2_Missense_Mutation_p.L2999F	NM_033026.5	NP_149015.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein						cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						CAGCTTCTGCTAAATTTGTGT	0.403000													27	119					0	0	1	0	0
PIGC	5279	broad.mit.edu	37	1	172411242	172411242	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr1:172411242G>C	ENST00000367728.1	-	1	1984	c.521C>G	c.(520-522)tCc>tGc	p.S174C	C1orf105_ENST00000367727.4_Intron|PIGC_ENST00000484368.1_Intron|PIGC_ENST00000344529.4_Missense_Mutation_p.S174C|PIGC_ENST00000258324.1_Missense_Mutation_p.S174C			Q92535	PIGC_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class C	174					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			breast(1)|endometrium(1)|kidney(1)|lung(1)	4						TAGTGTGCTGGATACAATGGC	0.478000													35	31					0	0	1	0	0
KCNH2	3757	broad.mit.edu	37	7	150648204	150648204	+	Silent	SNP	G	G	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr7:150648204G>T	ENST00000392968.2	-	6	2782	c.1662C>A	c.(1660-1662)ctC>ctA	p.L554L	KCNH2_ENST00000262186.5_Silent_p.L650L|KCNH2_ENST00000330883.4_Silent_p.L310L|KCNH2_ENST00000430723.3_Silent_p.L650L			Q12809	KCNH2_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 2	650					blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|cervix(1)|endometrium(10)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	42	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	TAGCATACATGAGGGCTGGGG	0.662000													5	25					2.0095e-06	2.1634e-06	1	1	0
RBFOX1	54715	broad.mit.edu	37	16	7703923	7703923	+	Silent	SNP	C	C	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr16:7703923C>A	ENST00000340209.4	+	9	1176	c.879C>A	c.(877-879)ccC>ccA	p.P293P	RBFOX1_ENST00000436368.2_Silent_p.P308P|RBFOX1_ENST00000547338.1_Silent_p.P288P|RBFOX1_ENST00000547372.1_Silent_p.P331P|RBFOX1_ENST00000422070.4_Silent_p.P331P|RBFOX1_ENST00000355637.4_Silent_p.P308P|RBFOX1_ENST00000550418.1_Silent_p.P288P|RBFOX1_ENST00000552089.1_Silent_p.P305P|RBFOX1_ENST00000535565.2_Silent_p.P245P|RBFOX1_ENST00000553186.1_Silent_p.P261P|RBFOX1_ENST00000311745.5_Silent_p.P308P			Q9NWB1	RFOX1_HUMAN	RNA binding protein, fox-1 homolog (C. elegans) 1	288					mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|lung(17)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)	55						ccgcggcgcccccgcccccgA	0.741000													5	13					1.23904e-05	1.32523e-05	1	1	0
RRN3	54700	broad.mit.edu	37	16	15168715	15168715	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr16:15168715C>T	ENST00000198767.6	-	11	945	c.862G>A	c.(862-864)Gaa>Aaa	p.E288K	RRN3_ENST00000540462.1_Missense_Mutation_p.E106K|RRN3_ENST00000563559.1_Missense_Mutation_p.E288K|RRN3_ENST00000327307.7_Missense_Mutation_p.E255K|PDXDC1_ENST00000535621.2_Intron|RRN3_ENST00000429751.2_Missense_Mutation_p.E258K	NM_018427.3	NP_060897.3	Q9NYV6	RRN3_HUMAN	RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)	288					regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm		p.E288K(1)		NS(2)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|prostate(2)	20						TCTTCATCTTCATCCTTTGAA	0.388000													3	11					0	0	1	0	0
PCBP4	57060	broad.mit.edu	37	3	51994202	51994202	+	Silent	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr3:51994202C>T	ENST00000395014.2	-	2	287	c.288G>A	c.(286-288)gtG>gtA	p.V96V	PCBP4_ENST00000471622.1_Intron|PCBP4_ENST00000428823.2_Intron|PCBP4_ENST00000355852.2_Intron|PCBP4_ENST00000484633.1_Intron|PCBP4_ENST00000461554.1_Intron|PCBP4_ENST00000322099.7_Intron|PCBP4_ENST00000395013.3_Intron			P57723	PCBP4_HUMAN	poly(rC) binding protein 4	127						cytoplasm|ribonucleoprotein complex	DNA binding|RNA binding			endometrium(2)|large_intestine(2)|lung(2)|prostate(1)|stomach(1)	8				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		TCTCGCCCCTCACCTCTCGGA	0.597000													28	42					0	0	1	0	0
POLR3A	11128	broad.mit.edu	37	10	79784793	79784793	+	Silent	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr10:79784793C>T	ENST00000372371.3	-	4	563	c.426G>A	c.(424-426)ctG>ctA	p.L142L		NM_007055.3	NP_008986.2	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide A, 155kDa	142					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding			breast(1)|endometrium(7)|kidney(3)|large_intestine(13)|lung(25)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	59	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			TTTTCTTTTTCAGTCCTCGCT	0.488000													19	24					0	0	1	0	0
SYNPO2	171024	broad.mit.edu	37	4	119948212	119948212	+	Missense_Mutation	SNP	G	G	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr4:119948212G>T	ENST00000307142.4	+	3	884	c.688G>T	c.(688-690)Gac>Tac	p.D230Y	SYNPO2_ENST00000429713.2_Missense_Mutation_p.D230Y|SYNPO2_ENST00000434046.2_Missense_Mutation_p.D230Y|SYNPO2_ENST00000448416.2_Intron	NM_133477.2	NP_597734.2	Q9UMS6	SYNP2_HUMAN	synaptopodin 2	230						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(18)|ovary(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						TCCTGACCCAGACCCTAACTT	0.493000													17	9					2.35188e-11	2.69726e-11	1	1	0
ANO2	57101	broad.mit.edu	37	12	5708736	5708736	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr12:5708736G>C	ENST00000546188.1	-	21	2221	c.2150C>G	c.(2149-2151)tCt>tGt	p.S717C	ANO2_ENST00000356134.5_Missense_Mutation_p.S717C|ANO2_ENST00000327087.8_Missense_Mutation_p.S716C			Q9NQ90	ANO2_HUMAN	anoctamin 2	721						chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(1)	58						CGAATGGGCAGAGTCAGTTTC	0.453000													25	91					0	0	1	0	0
CROCCP2	84809	broad.mit.edu	37	1	16945409	16945409	+	RNA	SNP	T	T	A	rs13566		TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr1:16945409T>A	ENST00000412962.1	-	0	2110																											GCGGGATAGCTCGGTGGAGAG	0.612000													8	32					0	0	1	0	0
CACNA1D	776	broad.mit.edu	37	3	53809940	53809940	+	Silent	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr3:53809940G>A	ENST00000288139.4	+	36	4408	c.4290G>A	c.(4288-4290)gaG>gaA	p.E1430E	CACNA1D_ENST00000422281.2_Silent_p.E1395E|CACNA1D_ENST00000350061.5_Silent_p.E1410E|CACNA1D_ENST00000540742.1_Silent_p.E302E	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit		Dihydropyridine binding (By similarity).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	CCTGGCAGGAGATCATGCTGG	0.498000													24	70					0	0	1	0	0
OR2T27	403239	broad.mit.edu	37	1	248813251	248813251	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr1:248813251C>T	ENST00000344889.3	-	1	934	c.935G>A	c.(934-936)gGa>gAa	p.G312E		NM_001001824.1	NP_001001824.1	Q8NH04	O2T27_HUMAN	olfactory receptor, family 2, subfamily T, member 27	312					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(2)|large_intestine(4)|lung(20)|skin(3)|stomach(1)	32	all_cancers(71;1.15e-05)|all_epithelial(71;5.29e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.089)|Lung NSC(105;0.0969)|Melanoma(84;0.199)	all_cancers(173;0.237)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GGTTACCTTTCCTGAGGACAC	0.428000													21	15					0	0	1	0	0
ADAMTS19	171019	broad.mit.edu	37	5	128983544	128983544	+	Silent	SNP	A	A	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr5:128983544A>T	ENST00000274487.4	+	12	2086	c.1941A>T	c.(1939-1941)cgA>cgT	p.R647R	CTC-575N7.1_ENST00000503616.1_RNA	NM_133638.3	NP_598377.3	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 19	647	TSP type-1 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		CTTGTAGCCGAACCTGCAGTG	0.522000													23	103					0	0	1	0	0
TAF1C	9013	broad.mit.edu	37	16	84215839	84215839	+	Silent	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr16:84215839G>C	ENST00000567759.1	-	7	872	c.690C>G	c.(688-690)gtC>gtG	p.V230V	TAF1C_ENST00000378541.4_Silent_p.V230V|TAF1C_ENST00000541676.1_Silent_p.V163V|TAF1C_ENST00000566732.1_Silent_p.V230V|TAF1C_ENST00000341690.6_Silent_p.V163V|TAF1C_ENST00000570117.1_5'UTR	NM_005679.3	NP_005670	Q15572	TAF1C_HUMAN	TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa	230					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding			endometrium(1)|kidney(3)|large_intestine(3)|lung(11)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	26						CAGCAGGGTAGACCAGCTGCC	0.652000													23	14					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75072309	75072309	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr1:75072309C>G	ENST00000326665.5	-	10	1683	c.1465G>C	c.(1465-1467)Gac>Cac	p.D489H	C1orf173_ENST00000420661.2_Missense_Mutation_p.D292H|RP4-612J11.1_ENST00000416017.1_RNA	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	489	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TTTTCCTGGTCGTCTTCCAAG	0.358000													4	48					0	0	1	0	0
IL17RC	84818	broad.mit.edu	37	3	9974296	9974296	+	Missense_Mutation	SNP	C	C	G	rs145526460		TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr3:9974296C>G	ENST00000295981.3	+	17	1823	c.1605C>G	c.(1603-1605)atC>atG	p.I535M	IL17RC_ENST00000498214.1_3'UTR|IL17RC_ENST00000403601.3_Missense_Mutation_p.I464M|IL17RC_ENST00000383812.4_Missense_Mutation_p.I449M|IL17RC_ENST00000416074.2_Missense_Mutation_p.I303M|IL17RC_ENST00000455057.1_Missense_Mutation_p.I432M|IL17RC_ENST00000413608.1_Missense_Mutation_p.I464M	NM_153461.3	NP_703191	Q8NAC3	I17RC_HUMAN	interleukin 17 receptor C	535						integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(3)|ovary(3)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						TCCCAGACATCCACAAGCGCT	0.542000													36	31					0	0	1	0	0
ITPR2	3709	broad.mit.edu	37	12	26714774	26714774	+	Nonsense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr12:26714774G>C	ENST00000381340.3	-	35	5158	c.4742C>G	c.(4741-4743)tCa>tGa	p.S1581*		NM_002223.2	NP_002214.2	Q14571	ITPR2_HUMAN	inositol 1,4,5-trisphosphate receptor, type 2	1581					activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity		ETV6/ITPR2(2)	biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(20)|liver(1)|lung(51)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	125	Colorectal(261;0.0847)					AGAGCGAGCTGATAGTCTCCA	0.443000													7	27					0	0	1	0	0
SORCS1	114815	broad.mit.edu	37	10	108469046	108469046	+	Nonsense_Mutation	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr10:108469046G>A	ENST00000263054.6	-	7	1085	c.1078C>T	c.(1078-1080)Cag>Tag	p.Q360*	SORCS1_ENST00000344440.6_Nonsense_Mutation_p.Q360*	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	360						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		GGAAAAGGCTGATTCCTGTTG	0.393000													5	27					0	0	1	0	0
ZNF91	7644	broad.mit.edu	37	19	23542848	23542848	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr19:23542848G>A	ENST00000300619.7	-	4	3138	c.2933C>T	c.(2932-2934)tCt>tTt	p.S978F	ZNF91_ENST00000599743.1_Intron|ZNF91_ENST00000397082.2_Missense_Mutation_p.S946F	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	978						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding						all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				AAGAGTTGAAGATTTCCTAAA	0.368000													6	16					0	0	1	0	0
KLF10	7071	broad.mit.edu	37	8	103662492	103662492	+	Silent	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr8:103662492C>T	ENST00000395884.3	-	4	2180	c.1278G>A	c.(1276-1278)cgG>cgA	p.R426R	KLF10_ENST00000285407.6_Silent_p.R437R	NM_001032282.2	NP_001027453.1	Q13118	KLF10_HUMAN	Kruppel-like factor 10	437					cell proliferation|cell-cell signaling|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|skeletal system development|transforming growth factor beta receptor signaling pathway	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(8)|prostate(3)	18	all_epithelial(15;5.63e-07)|Lung NSC(17;8.18e-05)|all_lung(17;0.000169)		OV - Ovarian serous cystadenocarcinoma(57;0.000112)|STAD - Stomach adenocarcinoma(118;0.0826)			TCCTCATGAACCGCCGGTCAC	0.522000													8	90					0	0	1	0	0
NCKAP5L	57701	broad.mit.edu	37	12	50191000	50191000	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr12:50191000G>C	ENST00000335999.6	-	8	844	c.643C>G	c.(643-645)Cca>Gca	p.P215A		NM_001037806.3	NP_001032895.2	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	211	Pro-rich.									central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(8)|prostate(2)	18						CCCTGGCCTGGAGGCCGCCAG	0.682000													15	14					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9017368	9017368	+	Missense_Mutation	SNP	G	G	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr19:9017368G>T	ENST00000397910.4	-	26	38159	c.37956C>A	c.(37954-37956)gaC>gaA	p.D12652E		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12654	SEA 4.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GACTGTTCCTGTCCAGGGTGT	0.567000													21	136					1.96895e-08	2.18673e-08	1	1	0
COL6A5	256076	broad.mit.edu	37	3	130095562	130095562	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr3:130095562C>G	ENST00000265379.6	+	3	1044	c.550C>G	c.(550-552)Cat>Gat	p.H184D	COL6A5_ENST00000432398.2_Missense_Mutation_p.H184D			A8TX70	CO6A5_HUMAN	collagen, type VI, alpha 5	184	Nonhelical region.|VWFA 1.				axon guidance|cell adhesion	collagen				endometrium(6)|kidney(4)|large_intestine(8)|lung(19)|pancreas(2)|prostate(3)|stomach(1)|urinary_tract(1)	44						GGCCACATCCCATTTCCATTT	0.483000													7	28					0	0	1	0	0
NOX5	79400	broad.mit.edu	37	15	69329383	69329383	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr15:69329383C>T	ENST00000260364.5	+	9	1451	c.1150C>T	c.(1150-1152)Cac>Tac	p.H384Y	NOX5_ENST00000448182.3_Missense_Mutation_p.H356Y|NOX5_ENST00000455873.3_Missense_Mutation_p.H367Y|NOX5_ENST00000388866.3_Missense_Mutation_p.H402Y|NOX5_ENST00000530406.2_Missense_Mutation_p.H374Y			Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	402	Ferric oxidoreductase.				angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(18)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35						CTATTGGACTCACCTGTCCTA	0.557000													13	86					0	0	1	0	0
ABHD6	57406	broad.mit.edu	37	3	58242398	58242398	+	Silent	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr3:58242398C>T	ENST00000478253.1	+	3	586	c.85C>T	c.(85-87)Ctg>Ttg	p.L29L	ABHD6_ENST00000295962.4_Silent_p.L29L			Q9BV23	ABHD6_HUMAN	abhydrolase domain containing 6	29						integral to membrane	acylglycerol lipase activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(1)	16				BRCA - Breast invasive adenocarcinoma(55;0.000225)|KIRC - Kidney renal clear cell carcinoma(284;0.0471)|Kidney(284;0.0589)|OV - Ovarian serous cystadenocarcinoma(275;0.209)		TTCATTTCTTCTGTGGCCTTC	0.428000													12	61					0	0	1	0	0
CBX6	23466	broad.mit.edu	37	22	39262341	39262341	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr22:39262341G>C	ENST00000407418.3	-	5	1235	c.1112C>G	c.(1111-1113)aCc>aGc	p.T371S	CBX6_ENST00000216083.6_Missense_Mutation_p.T353S			O95503	CBX6_HUMAN	chromobox homolog 6	371					chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	PcG protein complex				large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	6	Melanoma(58;0.04)					GGTGACATCGGTGACGACCAC	0.667000													19	18					0	0	1	0	0
CR1L	1379	broad.mit.edu	37	1	207867809	207867809	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr1:207867809G>C	ENST00000508064.2	+	5	635	c.575G>C	c.(574-576)aGa>aCa	p.R192T	CR1L_ENST00000530905.1_Intron	NM_175710.1	NP_783641.1	Q2VPA4	CR1L_HUMAN	complement component (3b/4b) receptor 1-like	192	Sushi 3.					cytoplasm|extracellular region|membrane				endometrium(1)|kidney(1)|large_intestine(2)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22						CTTGGAAGCAGAGGGAAAAAG	0.517000													26	64					0	0	1	0	0
MUC7	4589	broad.mit.edu	37	4	71347237	71347237	+	Missense_Mutation	SNP	C	C	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr4:71347237C>A	ENST00000413702.1	+	4	1064	c.776C>A	c.(775-777)gCt>gAt	p.A259D	MUC7_ENST00000456088.1_Missense_Mutation_p.A259D|MUC7_ENST00000304887.5_Missense_Mutation_p.A259D	NM_001145006.1	NP_001138478.1	Q8TAX7	MUC7_HUMAN	mucin 7, secreted	259	Thr-rich.					extracellular region	protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(2)|lung(23)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42			Lung(101;0.211)			GAGACCACAGCTGTCCCACCC	0.587000													11	167					1.5842e-08	1.76741e-08	1	1	0
PPP6R1	22870	broad.mit.edu	37	19	55741989	55741989	+	Silent	SNP	T	T	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr19:55741989T>C	ENST00000412770.2	-	23	3200	c.2634A>G	c.(2632-2634)ccA>ccG	p.P878P	PPP6R1_ENST00000587283.1_Silent_p.P878P	NM_014931.3	NP_055746.3	Q9UPN7	PP6R1_HUMAN	protein phosphatase 6, regulatory subunit 1	878	Pro-rich.				regulation of phosphoprotein phosphatase activity	cytoplasm	protein phosphatase binding			breast(1)	1						ACTGGGAGCCTGGGGATGCAG	0.647000													3	32					0	0	1	0	0
ARHGAP31	57514	broad.mit.edu	37	3	119133815	119133815	+	Silent	SNP	G	G	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr3:119133815G>T	ENST00000264245.4	+	12	3571	c.3039G>T	c.(3037-3039)ctG>ctT	p.L1013L		NM_020754.2	NP_065805.2	Q2M1Z3	RHG31_HUMAN	Rho GTPase activating protein 31	1013					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(3)|large_intestine(11)|lung(29)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	67						TCTCTGGCCTGAAAGGGGCAG	0.572000													7	50					2.7689e-08	3.06824e-08	1	1	0
ACTL6B	51412	broad.mit.edu	37	7	100252642	100252642	+	Splice_Site	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr7:100252642C>T	ENST00000160382.5	-	4	475	c.369G>A	c.(367-369)ccG>ccA	p.P123P		NM_016188.4	NP_057272.1	O94805	ACL6B_HUMAN	actin-like 6B	123					chromatin modification|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nBAF complex|SWI/SNF complex	ATP binding|protein binding|structural constituent of cytoskeleton	p.P123P(1)		endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|skin(1)	13	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					AGGCACTCACCGGAGCCTCGG	0.592000													5	23					0	0	1	0	0
COL22A1	169044	broad.mit.edu	37	8	139856338	139856338	+	Missense_Mutation	SNP	T	T	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr8:139856338T>A	ENST00000303045.6	-	4	1168	c.722A>T	c.(721-723)aAg>aTg	p.K241M	COL22A1_ENST00000435777.1_Missense_Mutation_p.K241M	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	241	TSP N-terminal.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TGTGATTTCCTTGGTTCCTCC	0.473000										HNSCC(7;0.00092)			13	107					0	0	1	0	0
SRSF8	10929	broad.mit.edu	37	11	94801254	94801254	+	RNA	SNP	G	G	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr11:94801254G>T	ENST00000529911.1	+	0	894					NM_032102.3	NP_115285.1	Q9BRL6	SRSF8_HUMAN	serine/arginine-rich splicing factor 8						mRNA processing|RNA splicing	nucleus	nucleotide binding|RNA binding										TGATGCATCAGGAAGCAACGT	0.493000													4	6					0.014758	0.0150019	1	1	0
LOXL2	4017	broad.mit.edu	37	8	23185981	23185981	+	Nonsense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr8:23185981C>T	ENST00000389131.3	-	6	1433	c.1064G>A	c.(1063-1065)tGg>tAg	p.W355*		NM_002318.2	NP_002309.1	Q9Y4K0	LOXL2_HUMAN	lysyl oxidase-like 2	355	SRCR 3.				aging|cell adhesion|protein modification process	extracellular space|membrane	copper ion binding|electron carrier activity|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|scavenger receptor activity			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(5)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(55;0.0453)|Breast(100;0.143)		Colorectal(74;0.0288)|COAD - Colon adenocarcinoma(73;0.096)		CACCAGGTCCCACTTGTCGTC	0.627000													7	47					0	0	1	0	0
ZMIZ1	57178	broad.mit.edu	37	10	81070880	81070880	+	Nonsense_Mutation	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr10:81070880C>G	ENST00000334512.5	+	24	3607	c.3035C>G	c.(3034-3036)tCa>tGa	p.S1012*	ZMIZ1_ENST00000446377.2_Intron	NM_020338.3	NP_065071.1	Q9ULJ6	ZMIZ1_HUMAN	zinc finger, MIZ-type containing 1	1012					transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(1)	30	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			AACCCCTCCTCAGCCTTAGAG	0.677000													30	75					0	0	1	0	0
POU6F2	11281	broad.mit.edu	37	7	39472768	39472768	+	Silent	SNP	C	C	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr7:39472768C>A	ENST00000518318.2	+	7	1161	c.1119C>A	c.(1117-1119)ccC>ccA	p.P373P	POU6F2_ENST00000559001.1_Silent_p.P318P|POU6F2_ENST00000403058.1_Silent_p.P373P			P78424	PO6F2_HUMAN	POU class 6 homeobox 2	373	Gln-rich.				central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(16)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	42						CAATCACCCCCCAGCTCCTCA	0.582000													23	55					2.89027e-11	3.29933e-11	1	1	0
UVSSA	57654	broad.mit.edu	37	4	1346904	1346904	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr4:1346904G>C	ENST00000389851.4	+	5	1084	c.637G>C	c.(637-639)Gag>Cag	p.E213Q	UVSSA_ENST00000507531.1_Missense_Mutation_p.E213Q|UVSSA_ENST00000511216.1_Missense_Mutation_p.E213Q	NM_020894.2	NP_065945.2	Q2YD98	K1530_HUMAN	UV-stimulated scaffold protein A	213																	CCCGAACCCGGAGACGGAATC	0.607000													5	38					0	0	1	0	0
CRNN	49860	broad.mit.edu	37	1	152383081	152383081	+	Silent	SNP	A	A	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr1:152383081A>T	ENST00000271835.3	-	3	539	c.477T>A	c.(475-477)acT>acA	p.T159T	RP1-91G5.3_ENST00000411804.1_RNA	NM_016190.2	NP_057274.1	Q9UBG3	CRNN_HUMAN	cornulin	159	Gln-rich.				cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACGCAGAGCCAGTGGCCTGAC	0.607000													80	159					0	0	1	0	0
GBP4	115361	broad.mit.edu	37	1	89655858	89655858	+	Missense_Mutation	SNP	C	C	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr1:89655858C>A	ENST00000355754.6	-	7	1157	c.1060G>T	c.(1060-1062)Gcc>Tcc	p.A354S		NM_052941.4	NP_443173.2	Q96PP9	GBP4_HUMAN	guanylate binding protein 4	354						cytoplasm	GTP binding|GTPase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(19)|skin(1)|stomach(2)|urinary_tract(1)	33				all cancers(265;0.00723)|Epithelial(280;0.0291)		AGTTGCTGGGCCATCTGCTGG	0.597000													5	36					0.000602214	0.000629065	1	1	0
ZNF665	79788	broad.mit.edu	37	19	53668042	53668042	+	Missense_Mutation	SNP	C	C	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr19:53668042C>A	ENST00000600412.1	-	2	1621	c.1506G>T	c.(1504-1506)gaG>gaT	p.E502D	ZNF665_ENST00000396424.3_Missense_Mutation_p.E567D			Q9H7R5	ZN665_HUMAN	zinc finger protein 665	502					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(16)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	35				GBM - Glioblastoma multiforme(134;0.0196)		TATAAGGTTTCTCACCAGTGT	0.388000													9	63					0.000442599	0.000464305	1	1	0
MARK4	57787	broad.mit.edu	37	19	45805712	45805712	+	Missense_Mutation	SNP	G	G	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr19:45805712G>T	ENST00000262891.4	+	17	2334	c.2003G>T	c.(2002-2004)cGc>cTc	p.R668L	MARK4_ENST00000300843.4_3'UTR	NM_001199867.1	NP_001186796.1	Q96L34	MARK4_HUMAN	MAP/microtubule affinity-regulating kinase 4	668					microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			NS(1)|biliary_tract(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	31		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		ACCAGCTCGCGCCCTCCTGAG	0.677000													17	135					4.7546e-09	5.34079e-09	1	1	0
CLVS1	157807	broad.mit.edu	37	8	62212710	62212710	+	Silent	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr8:62212710C>T	ENST00000519846.1	+	3	796	c.324C>T	c.(322-324)ttC>ttT	p.F108F	CLVS1_ENST00000325897.4_Silent_p.F108F|CLVS1_ENST00000518592.1_Intron			Q8IUQ0	CLVS1_HUMAN	clavesin 1	108					lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			endometrium(3)|kidney(4)|large_intestine(4)|lung(21)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	41						TGGACATGTTCAAAAACTTCA	0.507000													14	25					0	0	1	0	0
PCDHB5	26167	broad.mit.edu	37	5	140516197	140516197	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr5:140516197C>T	ENST00000231134.5	+	1	1398	c.1181C>T	c.(1180-1182)cCc>cTc	p.P394L		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		394	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTTTTGAAGCCCACATTAAAA	0.473000													8	47					0	0	1	0	0
C1orf87	127795	broad.mit.edu	37	1	60520969	60520969	+	Silent	SNP	C	C	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr1:60520969C>A	ENST00000371201.3	-	3	356	c.249G>T	c.(247-249)gtG>gtT	p.V83V	C1orf87_ENST00000450089.2_Silent_p.V83V	NM_152377.2	NP_689590.1	Q8N0U7	CA087_HUMAN	chromosome 1 open reading frame 87	83							calcium ion binding			breast(2)|endometrium(2)|large_intestine(6)|lung(19)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33						TTTTCTCTTTCACATCATCTG	0.438000													9	123					4.68919e-08	5.16126e-08	1	1	0
CCDC132	55610	broad.mit.edu	37	7	92987725	92987725	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr7:92987725G>A	ENST00000544910.1	+	29	3002	c.2782G>A	c.(2782-2784)Gat>Aat	p.D928N	CCDC132_ENST00000535481.1_Missense_Mutation_p.D678N|CCDC132_ENST00000305866.5_Missense_Mutation_p.D958N|CCDC132_ENST00000541136.1_3'UTR	NM_001257998.1	NP_001244927.1	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132	958										endometrium(1)|large_intestine(2)|lung(5)	8	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			AGCTATAGATGATATAGACAG	0.393000													14	66					0	0	1	0	0
DHX30	22907	broad.mit.edu	37	3	47888164	47888164	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr3:47888164C>G	ENST00000446256.2	+	12	2057	c.1485C>G	c.(1483-1485)ttC>ttG	p.F495L	DHX30_ENST00000457607.1_Missense_Mutation_p.F562L|DHX30_ENST00000348968.4_Missense_Mutation_p.F506L|DHX30_ENST00000445061.1_Missense_Mutation_p.F534L	NM_014966.3	NP_055781.2	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 30	534	Helicase ATP-binding.					mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			endometrium(3)|kidney(1)|large_intestine(11)|lung(13)|ovary(4)|pancreas(1)|prostate(1)|skin(3)	37				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		CCCTGCTCTTCTGCACTGTGG	0.647000													8	47					0	0	1	0	0
NR0B1	190	broad.mit.edu	37	X	30327166	30327166	+	Missense_Mutation	SNP	C	C	G	rs132630327		TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chrX:30327166C>G	ENST00000378970.4	-	1	549	c.315G>C	c.(313-315)tgG>tgC	p.W105C	NR0B1_ENST00000453287.1_Missense_Mutation_p.W105C	NM_000475.4	NP_000466.2	P51843	NR0B1_HUMAN	nuclear receptor subfamily 0, group B, member 1	105	4 X 67 AA tandem repeats.				adrenal gland development|hypothalamus development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of steroid hormone receptor signaling pathway|pituitary gland development|protein localization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid biosynthetic process	cytoplasm|membrane fraction|nucleoplasm|nucleus|polysomal ribosome	AF-2 domain binding|DNA hairpin binding|ligand-regulated transcription factor activity|protein domain specific binding|protein homodimerization activity|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|steroid hormone receptor binding|transcription corepressor activity|transcription factor binding			central_nervous_system(2)|endometrium(2)|large_intestine(4)|lung(13)|ovary(1)|skin(2)	24					Dexamethasone(DB01234)|Tretinoin(DB00755)	ACGAACAGCCCCAGCACGGAC	0.682000											OREG0019719	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	25					0	0	1	0	0
INPP1	3628	broad.mit.edu	37	2	191231488	191231488	+	Silent	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr2:191231488C>G	ENST00000392329.2	+	5	1033	c.333C>G	c.(331-333)ctC>ctG	p.L111L	INPP1_ENST00000541441.1_Silent_p.L111L|INPP1_ENST00000322522.4_Silent_p.L111L	NM_001128928.1	NP_001122400.1	P49441	INPP_HUMAN	inositol polyphosphate-1-phosphatase	111					signal transduction		inositol-1,4-bisphosphate 1-phosphatase activity|metal ion binding			cervix(1)|large_intestine(2)|lung(6)|ovary(1)|urinary_tract(1)	11			OV - Ovarian serous cystadenocarcinoma(117;0.000286)|Epithelial(96;0.0186)|all cancers(119;0.057)		Lithium(DB01356)	GCAAAGTCCTCAATGGTAACA	0.453000													40	54					0	0	1	0	0
SLC39A6	25800	broad.mit.edu	37	18	33703556	33703556	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr18:33703556G>A	ENST00000269187.5	-	4	1255	c.1042C>T	c.(1042-1044)Ctc>Ttc	p.L348F	SLC39A6_ENST00000440549.2_Missense_Mutation_p.L73F|SLC39A6_ENST00000590986.1_Missense_Mutation_p.L348F	NM_012319.3	NP_036451	Q13433	S39A6_HUMAN	solute carrier family 39 (zinc transporter), member 6	348						integral to membrane|lamellipodium membrane	zinc ion transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(4)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	41						CGATTCATGAGAGGCACTAAG	0.443000													25	107					0	0	1	0	0
HIST1H2AH	85235	broad.mit.edu	37	6	27115202	27115202	+	Missense_Mutation	SNP	G	G	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr6:27115202G>T	ENST00000377459.1	+	1	342	c.295G>T	c.(295-297)Ggc>Tgc	p.G99C		NM_080596.1	NP_542163.1	Q96KK5	H2A1H_HUMAN	histone cluster 1, H2ah	99					nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(7)|prostate(1)|skin(1)	12						CAAGCTGCTGGGCAAAGTCAC	0.592000													12	111					2.27111e-07	2.47209e-07	1	1	0
EIF2AK3	9451	broad.mit.edu	37	2	88890568	88890568	+	Missense_Mutation	SNP	C	C	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr2:88890568C>A	ENST00000303236.3	-	5	1071	c.770G>T	c.(769-771)tGg>tTg	p.W257L	EIF2AK3_ENST00000419748.1_Missense_Mutation_p.W106L	NM_004836.5	NP_004827.4	Q9NZJ5	E2AK3_HUMAN	eukaryotic translation initiation factor 2-alpha kinase 3	257					activation of caspase activity|bone mineralization|calcium-mediated signaling|chondrocyte development|endocrine pancreas development|endoplasmic reticulum organization|endoplasmic reticulum unfolded protein response|ER overload response|insulin secretion|insulin-like growth factor receptor signaling pathway|negative regulation of myelination|negative regulation of translational initiation in response to stress|protein autophosphorylation|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|identical protein binding			ovary(3)	3						ACTGAAATTCCACCTTAAATT	0.333000													3	35					0.115264	0.115734	1	1	0
SSH2	85464	broad.mit.edu	37	17	27977760	27977760	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr17:27977760C>G	ENST00000269033.3	-	12	1208	c.1057G>C	c.(1057-1059)Gag>Cag	p.E353Q	SSH2_ENST00000540801.1_Missense_Mutation_p.E380Q|RP11-68I3.2_ENST00000581474.1_RNA	NM_001282129.1|NM_033389.2	NP_001269058.1|NP_203747.2	Q76I76	SSH2_HUMAN	slingshot protein phosphatase 2	353	Tyrosine-protein phosphatase.				actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity		SSH2/SUZ12(2)	breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						TTATGATACTCAAAGACTCCT	0.418000													20	63					0	0	1	0	0
ATL1	51062	broad.mit.edu	37	14	51094844	51094844	+	Silent	SNP	G	G	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr14:51094844G>T	ENST00000441560.2	+	13	1696	c.1215G>T	c.(1213-1215)gtG>gtT	p.V405V	ATL1_ENST00000358385.6_Silent_p.V405V|ATL1_ENST00000354525.4_Silent_p.V405V|ATL1_ENST00000357032.3_Silent_p.V405V	NM_001127713.1	NP_001121185.1	Q8WXF7	ATLA1_HUMAN	atlastin GTPase 1	405					axonogenesis|cell death|endoplasmic reticulum organization|protein homooligomerization	axon|endoplasmic reticulum membrane|Golgi cis cisterna|Golgi membrane|integral to membrane|microsome	GTP binding|GTPase activity|identical protein binding			central_nervous_system(1)|cervix(2)|large_intestine(4)|liver(1)|lung(6)|ovary(1)|skin(3)	18						TCCGAGGGGTGAAGAAGATGG	0.443000													29	8					3.73988e-18	4.38101e-18	1	1	0
AKAP9	10142	broad.mit.edu	37	7	91715563	91715563	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr7:91715563C>G	ENST00000359028.2	+	37	9283	c.9058C>G	c.(9058-9060)Cat>Gat	p.H3020D	AKAP9_ENST00000356239.3_Missense_Mutation_p.H3016D|AKAP9_ENST00000358100.2_Missense_Mutation_p.H2966D			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	3020					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TTCTCAATCTCATGAGAGCTT	0.358000			T	BRAF	papillary thyroid								17	78					0	0	1	0	0
MYO15A	51168	broad.mit.edu	37	17	18059590	18059590	+	Silent	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr17:18059590C>T	ENST00000205890.5	+	48	8879	c.8541C>T	c.(8539-8541)ttC>ttT	p.F2847F	MYO15A_ENST00000418233.3_Silent_p.F111F	NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	2847	Tail.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					TCATCCTCTTCTCAGCCCGAG	0.552000													29	11					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187627993	187627993	+	Missense_Mutation	SNP	A	A	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr4:187627993A>G	ENST00000441802.2	-	2	3198	c.2989T>C	c.(2989-2991)Tat>Cat	p.Y997H		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	997	Cadherin 8.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						GTGAGATTATACACTTGCTTC	0.458000										HNSCC(5;0.00058)			6	44					0	0	1	0	0
C3orf56	285311	broad.mit.edu	37	3	126916019	126916019	+	Nonsense_Mutation	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr3:126916019C>G	ENST00000398112.1	+	2	731	c.491C>G	c.(490-492)tCa>tGa	p.S164*		NM_001007534.2	NP_001007535.1			chromosome 3 open reading frame 56											breast(1)|endometrium(2)|kidney(1)|lung(5)	9				GBM - Glioblastoma multiforme(114;0.142)		CCAGCCAGCTCAGCCCCCAGG	0.627000													21	59					0	0	1	0	0
C10orf88	80007	broad.mit.edu	37	10	124708315	124708315	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr10:124708315C>T	ENST00000481909.1	-	4	722	c.498G>A	c.(496-498)atG>atA	p.M166I	C10orf88_ENST00000368891.5_5'UTR	NM_024942.3	NP_079218.2	Q9H8K7	CJ088_HUMAN	chromosome 10 open reading frame 88	166										breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(11)|prostate(1)	18		all_neural(114;0.0765)|Lung NSC(174;0.163)|all_lung(145;0.205)		Colorectal(40;0.0686)|COAD - Colon adenocarcinoma(40;0.0735)		AAACTGATCTCATGTGTACCA	0.388000													5	26					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139153499	139153499	+	Silent	SNP	C	C	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr8:139153499C>A	ENST00000395297.1	-	17	3902	c.3732G>T	c.(3730-3732)ctG>ctT	p.L1244L		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	1244										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CAGAGAGTGACAGGAACGTGT	0.507000										HNSCC(54;0.14)			9	71					0.000442599	0.000464305	1	1	0
OR10A2	341276	broad.mit.edu	37	11	6891294	6891294	+	Silent	SNP	T	T	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr11:6891294T>A	ENST00000307322.4	+	1	371	c.309T>A	c.(307-309)gcT>gcA	p.A103A		NM_001004460.1	NP_001004460.1	Q9H208	O10A2_HUMAN	olfactory receptor, family 10, subfamily A, member 2	103					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(12)|urinary_tract(1)	24		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.89e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		TCCTCCTGGCTACCATGGCAT	0.537000													16	88					0	0	1	0	0
CACNG7	59284	broad.mit.edu	37	19	54416232	54416232	+	Missense_Mutation	SNP	G	G	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr19:54416232G>T	ENST00000391767.1	+	2	359	c.147G>T	c.(145-147)gaG>gaT	p.E49D	CACNG7_ENST00000222212.2_Missense_Mutation_p.E49D|CACNG7_ENST00000468076.1_Intron|CACNG7_ENST00000391766.1_Missense_Mutation_p.E49D			P62955	CCG7_HUMAN	calcium channel, voltage-dependent, gamma subunit 7	49					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0711)		AGACCACCGAGGTCAAGATGG	0.602000													5	29					1.024e-07	1.12457e-07	1	1	0
CRISPLD1	83690	broad.mit.edu	37	8	75929607	75929607	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr8:75929607G>A	ENST00000262207.4	+	10	1517	c.1049G>A	c.(1048-1050)gGt>gAt	p.G350D	CRISPLD1_ENST00000523524.1_Missense_Mutation_p.G162D|CRISPLD1_ENST00000517786.1_Missense_Mutation_p.G164D	NM_031461.5	NP_113649.1	Q9H336	CRLD1_HUMAN	cysteine-rich secretory protein LCCL domain containing 1	350	LCCL 1.					extracellular region				biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(7)|large_intestine(10)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Breast(64;0.0799)		Epithelial(68;0.155)|BRCA - Breast invasive adenocarcinoma(89;0.161)			GACAATGATGGTGGCTGGGTA	0.328000													24	48					0	0	1	0	0
ZBP1	81030	broad.mit.edu	37	20	56179636	56179636	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr20:56179636C>G	ENST00000340462.4	-	7	1494	c.1214G>C	c.(1213-1215)gGg>gCg	p.G405A	ZBP1_ENST00000395822.3_Missense_Mutation_p.G353A|ZBP1_ENST00000371173.3_Missense_Mutation_p.G428A			Q9H171	ZBP1_HUMAN	Z-DNA binding protein 1	428						cytoplasm|nucleus	double-stranded RNA adenosine deaminase activity|left-handed Z-DNA binding|RNA binding			large_intestine(11)|lung(8)|ovary(4)|prostate(1)|skin(2)|urinary_tract(1)	27	Lung NSC(12;0.000545)|all_lung(29;0.00195)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;7.87e-13)|Epithelial(14;3.26e-09)|all cancers(14;3.62e-08)			GCACTAAATCCCACCTCCCCA	0.567000													5	85					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166852550	166852550	+	Missense_Mutation	SNP	T	T	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr2:166852550T>G	ENST00000423058.2	-	24	4571	c.4554A>C	c.(4552-4554)aaA>aaC	p.K1518N	AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000303395.4_Missense_Mutation_p.K1518N|SCN1A_ENST00000409050.1_Missense_Mutation_p.K1490N|SCN1A_ENST00000375405.3_Missense_Mutation_p.K1507N|AC010127.3_ENST00000597623.1_RNA	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	1518						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	GCTTTTGCGGTTTTTTCGATC	0.323000													5	35					0	0	1	0	0
HNRNPA0	10949	broad.mit.edu	37	5	137089348	137089348	+	Silent	SNP	G	G	C	rs143964663	by1000genomes	TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr5:137089348G>C	ENST00000314940.4	-	1	691	c.408C>G	c.(406-408)ggC>ggG	p.G136G		NM_006805.3	NP_006796.1	Q13151	ROA0_HUMAN	heterogeneous nuclear ribonucleoprotein A0	136	RRM 2.				nuclear mRNA splicing, via spliceosome	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|RNA binding			large_intestine(1)|lung(2)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CACGCTTCTTGCCGGACTGCT	0.582000													6	40					0	0	1	0	0
NCKAP5L	57701	broad.mit.edu	37	12	50190310	50190310	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr12:50190310G>C	ENST00000335999.6	-	8	1534	c.1333C>G	c.(1333-1335)Cag>Gag	p.Q445E		NM_001037806.3	NP_001032895.2	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	441	Pro-rich.									central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(8)|prostate(2)	18						AGGGGTCCCTGAGCTTCCCCA	0.627000													13	11					0	0	1	0	0
LCK	3932	broad.mit.edu	37	1	32745472	32745472	+	Silent	SNP	C	C	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr1:32745472C>A	ENST00000333070.4	+	11	1262	c.1162C>A	c.(1162-1164)Cgg>Agg	p.R388R	LCK_ENST00000373564.3_Silent_p.R365R|LCK_ENST00000336890.5_Silent_p.R358R	NM_001042771.1	NP_001036236.1	P06239	LCK_HUMAN	lymphocyte-specific protein tyrosine kinase	358	Protein kinase.				activation of caspase activity|cellular zinc ion homeostasis|induction of apoptosis|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of T cell receptor signaling pathway|regulation of defense response to virus by virus|release of sequestered calcium ion into cytosol|response to drug|T cell costimulation|T cell differentiation|T cell receptor signaling pathway|viral reproduction	cytosol|Golgi apparatus|membrane raft|pericentriolar material|plasma membrane	ATP binding|ATPase binding|CD4 receptor binding|CD8 receptor binding|glycoprotein binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein kinase binding|protein serine/threonine phosphatase activity|SH2 domain binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	37		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)			Dasatinib(DB01254)	CATTGAAGAGCGGAATTATAT	0.522000			T	TRB@	T-ALL								13	59					1.15088e-07	1.2611e-07	1	1	0
JAK2	3717	broad.mit.edu	37	9	5044482	5044482	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr9:5044482C>G	ENST00000381652.3	+	5	924	c.430C>G	c.(430-432)Ctt>Gtt	p.L144V	JAK2_ENST00000539801.1_Missense_Mutation_p.L144V|JAK2_ENST00000544510.1_5'UTR	NM_004972.3	NP_004963.1	O60674	JAK2_HUMAN	Janus kinase 2	144	FERM.|Interaction with cytokine/interferon/growth hormone receptors (By similarity).				actin filament polymerization|activation of caspase activity by protein phosphorylation|activation of JAK2 kinase activity|blood coagulation|cellular component movement|erythrocyte differentiation|interferon-gamma-mediated signaling pathway|interleukin-12-mediated signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|mammary gland epithelium development|mesoderm development|negative regulation of cell proliferation|negative regulation of DNA binding|positive regulation of apoptosis|positive regulation of cell-substrate adhesion|positive regulation of growth hormone receptor signaling pathway|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|protein autophosphorylation|regulation of inflammatory response|regulation of interferon-gamma-mediated signaling pathway|response to antibiotic|response to lipopolysaccharide|STAT protein import into nucleus|tumor necrosis factor-mediated signaling pathway|tyrosine phosphorylation of STAT protein	caveola|cytoskeleton|cytosol|endomembrane system|nucleus	ATP binding|growth hormone receptor binding|heme binding|histone binding|histone kinase activity (H3-Y41 specific)|interleukin-12 receptor binding|non-membrane spanning protein tyrosine kinase activity|protein kinase binding|SH2 domain binding		BCR/JAK2(6)|SSBP2/JAK2(4)|SEC31A/JAK2(4)|ETV6/JAK2(11)|PCM1/JAK2(30)|PAX5/JAK2(18)	breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(32944)|kidney(4)|large_intestine(10)|liver(1)|lung(20)|ovary(3)|prostate(4)|skin(2)|urinary_tract(1)	32998	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0198)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0237)|Lung(218;0.133)		TGAAGCTCCTCTTCTTGATGA	0.358000		1	"""T, Mis, O"""	"""ETV6, PCM1, BCR"""	"""ALL, AML, MPD,  CML"""				Polycythemia Vera, Familial				12	7					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228509806	228509806	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr1:228509806C>G	ENST00000570156.2	+	66	18209	c.18135C>G	c.(18133-18135)atC>atG	p.I6045M	OBSCN_ENST00000284548.11_Missense_Mutation_p.I5088M|OBSCN_ENST00000366709.4_Missense_Mutation_p.I2207M|OBSCN_ENST00000366707.4_Missense_Mutation_p.I2722M|OBSCN_ENST00000422127.1_Missense_Mutation_p.I5088M	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	5088	Ig-like 52.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GGGTGGAGATCAAGCTGGTGG	0.582000													10	5					0	0	1	0	0
ICA1L	130026	broad.mit.edu	37	2	203680704	203680704	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr2:203680704G>A	ENST00000392237.2	-	8	870	c.713C>T	c.(712-714)aCa>aTa	p.T238I	ICA1L_ENST00000358299.2_Missense_Mutation_p.T238I	NM_138468.4	NP_612477.3	Q8NDH6	ICA1L_HUMAN	islet cell autoantigen 1,69kDa-like	238	AH.									breast(1)|endometrium(1)|large_intestine(7)|lung(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						CATTCGAGCTGTTTTCTTCCA	0.388000													19	13					0	0	1	0	0
SQRDL	58472	broad.mit.edu	37	15	45968409	45968409	+	Silent	SNP	C	C	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr15:45968409C>A	ENST00000260324.7	+	6	1151	c.765C>A	c.(763-765)ctC>ctA	p.L255L	SQRDL_ENST00000568606.1_Silent_p.L255L|RP11-96O20.4_ENST00000564080.1_Silent_p.L255L	NM_021199.3	NP_067022.1	Q9Y6N5	SQRD_HUMAN	sulfide quinone reductase-like (yeast)	255							oxidoreductase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)	11		Lung NSC(122;0.000117)|all_lung(180;0.000737)|Melanoma(134;0.0417)		all cancers(107;5.89e-18)|GBM - Glioblastoma multiforme(94;1.21e-06)|COAD - Colon adenocarcinoma(120;0.17)|Colorectal(133;0.188)		AGCGGAACCTCACTGTTAACT	0.458000													16	105					3.45872e-05	3.6913e-05	1	1	0
IFT43	112752	broad.mit.edu	37	14	76548637	76548637	+	Splice_Site	SNP	G	G	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr14:76548637G>T	ENST00000314067.6	+	6	329		c.e6-1		IFT43_ENST00000238628.6_Splice_Site	NM_001102564.1	NP_001096034.1	Q96FT9	IFT43_HUMAN	intraflagellar transport 43 homolog (Chlamydomonas)						cilium morphogenesis|intraflagellar retrograde transport					endometrium(1)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15						TCTCCTTGCAGATATTCCTAT	0.498000													92	41					3.37413e-40	4.00983e-40	1	1	0
PDZK1	5174	broad.mit.edu	37	1	145748572	145748572	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr1:145748572C>G	ENST00000344770.2	+	3	518	c.445C>G	c.(445-447)Ctg>Gtg	p.L149V	PDZK1_ENST00000417171.1_Missense_Mutation_p.L149V|PDZK1_ENST00000451928.2_Missense_Mutation_p.L149V	NM_002614.4	NP_002605.2	Q5T2W1	NHRF3_HUMAN	PDZ domain containing 1	149	PDZ 2.				carnitine transport|cell proliferation|drug transport|positive regulation of ion transmembrane transport	brush border membrane|cytoplasm	PDZ domain binding|transporter activity			NS(1)|endometrium(1)|large_intestine(1)|lung(3)|pancreas(1)	7	all_hematologic(18;0.00473)|Acute lymphoblastic leukemia(18;0.0786)		KIRC - Kidney renal clear cell carcinoma(6;0.0764)|Kidney(552;0.118)|Colorectal(543;0.229)			TGGCTTCTCTCTGAAAACTGT	0.512000													6	34					0	0	1	0	0
FMNL3	91010	broad.mit.edu	37	12	50047556	50047556	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr12:50047556C>G	ENST00000335154.5	-	12	1406	c.1173G>C	c.(1171-1173)aaG>aaC	p.K391N	FMNL3_ENST00000293590.5_Missense_Mutation_p.K391N|FMNL3_ENST00000352151.5_Missense_Mutation_p.K340N|FMNL3_ENST00000550488.1_Missense_Mutation_p.K391N	NM_175736.4	NP_783863.4	Q8IVF7	FMNL3_HUMAN	formin-like 3	391	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			breast(4)|endometrium(7)|kidney(2)|large_intestine(6)|lung(11)|ovary(2)|pancreas(2)|prostate(2)|skin(2)|stomach(1)	39						GGGCTACATTCTTGGTCTCAG	0.527000													26	103					0	0	1	0	0
ARL14	80117	broad.mit.edu	37	3	160395553	160395553	+	Missense_Mutation	SNP	T	T	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr3:160395553T>C	ENST00000320767.2	+	1	606	c.419T>C	c.(418-420)tTc>tCc	p.F140S		NM_025047.2	NP_079323.1	Q8N4G2	ARL14_HUMAN	ADP-ribosylation factor-like 14	140					small GTPase mediated signal transduction	intracellular	GTP binding			lung(6)	6			Lung(72;7.02e-05)|LUSC - Lung squamous cell carcinoma(72;7.23e-05)			ACCAGAATGTTCAAAGTGAAG	0.478000													8	61					0	0	1	0	0
CCDC67	159989	broad.mit.edu	37	11	93170884	93170884	+	Silent	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr11:93170884G>A	ENST00000298050.3	+	14	1914	c.1814G>A	c.(1813-1815)tGa>tAa	p.*605*	CCDC67_ENST00000525646.1_Silent_p.*347*	NM_181645.3	NP_857596.2	Q05D60	CCD67_HUMAN	coiled-coil domain containing 67	0										endometrium(3)|kidney(1)|large_intestine(1)|lung(10)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		Acute lymphoblastic leukemia(157;2.35e-05)|all_hematologic(158;0.00824)				AGACACATATGAGCTTTTAAA	0.333000													22	9					0	0	1	0	0
SVIL	6840	broad.mit.edu	37	10	29812498	29812498	+	Silent	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr10:29812498C>T	ENST00000375398.2	-	17	3494	c.3045G>A	c.(3043-3045)ccG>ccA	p.P1015P	SVIL_ENST00000355867.4_Silent_p.P1015P|SVIL_ENST00000375400.3_Silent_p.P589P			O95425	SVIL_HUMAN	supervillin	1015					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding	p.P1015P(1)		breast(1)|central_nervous_system(3)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(24)|lung(35)|ovary(8)|prostate(2)|skin(4)|stomach(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	112		Breast(68;0.103)				AAAATTCCTTCGGTTCATCCC	0.498000													15	21					0	0	1	0	0
RANGAP1	5905	broad.mit.edu	37	22	41645814	41645814	+	Silent	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr22:41645814C>T	ENST00000455915.2	-	13	2960	c.1491G>A	c.(1489-1491)ctG>ctA	p.L497L	RANGAP1_ENST00000356244.3_Silent_p.L497L|RANGAP1_ENST00000405486.1_Silent_p.L497L|RANGAP1_ENST00000407260.4_Silent_p.L442L			P46060	RAGP1_HUMAN	Ran GTPase activating protein 1	497					mitotic prometaphase|signal transduction	condensed chromosome kinetochore|cytosol|nuclear membrane|nuclear pore|soluble fraction|spindle pole	protein binding|Ran GTPase activator activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						CCTTCTGCATCAGGGCATCTG	0.617000													8	28					0	0	1	0	0
FCRL2	79368	broad.mit.edu	37	1	157738478	157738478	+	Silent	SNP	A	A	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr1:157738478A>G	ENST00000361516.3	-	5	657	c.609T>C	c.(607-609)tcT>tcC	p.S203S	FCRL2_ENST00000368181.4_Intron|FCRL2_ENST00000392274.3_Silent_p.S203S	NM_030764.3	NP_110391.2	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2	203	Ig-like C2-type 3.				cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity			central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|skin(2)	51	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			AGCTTACATTAGAGATGGGGA	0.483000													11	105					0	0	1	0	0
FANK1	92565	broad.mit.edu	37	10	127697960	127697960	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr10:127697960G>A	ENST00000368695.1	+	11	1095	c.973G>A	c.(973-975)Gaa>Aaa	p.E325K	FANK1_ENST00000477963.1_3'UTR|FANK1_ENST00000368693.1_Missense_Mutation_p.E331K	NM_145235.3	NP_660278.3	Q8TC84	FANK1_HUMAN	fibronectin type III and ankyrin repeat domains 1	331						cytoplasm|nucleus				central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(10)|ovary(1)|urinary_tract(1)	21		all_lung(145;0.00752)|Lung NSC(174;0.0115)|Colorectal(57;0.0847)|all_neural(114;0.0936)				CTCCTTATTAGAAGAAAGGAA	0.413000													7	13					0	0	1	0	0
CST8	10047	broad.mit.edu	37	20	23473662	23473662	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr20:23473662G>C	ENST00000246012.1	+	3	656	c.299G>C	c.(298-300)aGc>aCc	p.S100T		NM_005492.2	NP_005483.1	O60676	CST8_HUMAN	cystatin 8 (cystatin-related epididymal specific)	100						extracellular region	cysteine-type endopeptidase inhibitor activity			breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(9)|skin(2)	16	Colorectal(13;0.0431)|Lung NSC(19;0.235)					AAGCCTTTAAGCACTAATGAA	0.423000													11	89					0	0	1	0	0
CACNB1	782	broad.mit.edu	37	17	37343762	37343762	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr17:37343762G>C	ENST00000394303.3	-	4	591	c.384C>G	c.(382-384)ttC>ttG	p.F128L	CACNB1_ENST00000394310.3_Missense_Mutation_p.F128L|CACNB1_ENST00000582877.1_5'UTR|CACNB1_ENST00000344140.5_Missense_Mutation_p.F128L	NM_000723.4	NP_000714.3	Q02641	CACB1_HUMAN	calcium channel, voltage-dependent, beta 1 subunit	128	SH3.				axon guidance	voltage-gated calcium channel complex				breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(3)|ovary(1)|prostate(1)|skin(1)	16					Ibutilide(DB00308)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Verapamil(DB00661)	CTTTGGGCTCGAAGGTGATGG	0.572000													32	70					0	0	1	0	0
EIF4E3	317649	broad.mit.edu	37	3	71739207	71739207	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr3:71739207G>C	ENST00000425534.3	-	6	589	c.582C>G	c.(580-582)atC>atG	p.I194M	EIF4E3_ENST00000389826.3_Missense_Mutation_p.I88M|EIF4E3_ENST00000448225.1_Missense_Mutation_p.I88M|EIF4E3_ENST00000468147.1_5'UTR|EIF4E3_ENST00000421769.2_Missense_Mutation_p.I88M|EIF4E3_ENST00000295612.3_Missense_Mutation_p.I88M	NM_001134651.1	NP_001128123.1	Q8N5X7	IF4E3_HUMAN	eukaryotic translation initiation factor 4E family member 3						regulation of translation	cytoplasm|mRNA cap binding complex	translation initiation factor activity			large_intestine(1)|lung(3)	4		Prostate(10;0.0166)		BRCA - Breast invasive adenocarcinoma(55;2.56e-05)|Epithelial(33;2.9e-05)|Lung(16;9.28e-05)|LUSC - Lung squamous cell carcinoma(21;0.00227)		GAAGTTCATAGATCTTTTCTA	0.373000													11	16					0	0	1	0	0
RUNX2	860	broad.mit.edu	37	6	45390448	45390448	+	Silent	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr6:45390448G>A	ENST00000371438.1	+	2	535	c.177G>A	c.(175-177)caG>caA	p.Q59Q	RUNX2_ENST00000541979.1_Silent_p.Q127Q|RUNX2_ENST00000359524.5_Silent_p.Q45Q|RUNX2_ENST00000465038.2_Silent_p.Q59Q|RUNX2_ENST00000352853.5_Silent_p.Q127Q|RUNX2_ENST00000371432.3_Silent_p.Q45Q|RUNX2_ENST00000371436.6_Silent_p.Q59Q|RUNX2_ENST00000576263.1_Silent_p.Q59Q	NM_001024630.3	NP_001019801.3	Q13950	RUNX2_HUMAN	runt-related transcription factor 2	59	Poly-Gln.				negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(18)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						agcagcaacagcagcagcagc	0.726000													4	65					0	0	1	0	0
KNSTRN	90417	broad.mit.edu	37	15	40675213	40675213	+	Silent	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr15:40675213G>A	ENST00000416151.2	+	1	292	c.177G>A	c.(175-177)gaG>gaA	p.E59E	KNSTRN_ENST00000249776.8_Silent_p.E59E|KNSTRN_ENST00000608100.1_5'UTR|KNSTRN_ENST00000448395.2_Silent_p.E59E	NM_001142761.1	NP_001136233.1			kinetochore-localized astrin/SPAG5 binding protein																		ACGAGAGCGAGAAGGACTGCG	0.617000													18	102					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178936082	178936082	+	Missense_Mutation	SNP	G	G	A	rs121913273		TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr3:178936082G>A	ENST00000263967.3	+	10	1781	c.1624G>A	c.(1624-1626)Gaa>Aaa	p.E542K		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	542	PI3K helical.		E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).|E -> V (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(545)|p.E542Q(10)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCCTCTCTCTGAAATCACTGA	0.333000	E542K(BT483_BREAST)|E542K(CAL51_BREAST)|E542K(HGC27_STOMACH)|E542K(IM95_STOMACH)|E542K(JHUEM1_ENDOMETRIUM)|E542K(NCIH1341_LUNG)|E542K(SW948_LARGE_INTESTINE)|E542K(T84_LARGE_INTESTINE)|E542K(VMCUB1_URINARY_TRACT)	57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			20	8					0	0	1	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79058074	79058074	+	Silent	SNP	C	C	T	rs2929157		TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr15:79058074C>T	ENST00000388820.4	-	19	4389	c.4179G>A	c.(4177-4179)ccG>ccA	p.P1393P		NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	1393					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						TGGGAGCCAGCGGCTGGGTCT	0.682000													22	22					0	0	1	0	0
IGF2R	3482	broad.mit.edu	37	6	160490985	160490985	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr6:160490985G>C	ENST00000356956.1	+	31	4486	c.4338G>C	c.(4336-4338)tgG>tgC	p.W1446C		NM_000876.2	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor	1446					receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			breast(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(27)|lung(31)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		GACCTCAGTGGAGAGATGGCA	0.572000													5	20					0	0	1	0	0
RAPGEF2	9693	broad.mit.edu	37	4	160264498	160264498	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr4:160264498C>T	ENST00000264431.4	+	16	3132	c.2713C>T	c.(2713-2715)Cgt>Tgt	p.R905C		NM_014247.2	NP_055062.1	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor (GEF) 2	905	Ras-GEF.				cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	70	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		AAAAGAAATTCGTCACGTTGG	0.458000													8	43					0	0	1	0	0
EIF3B	8662	broad.mit.edu	37	7	2403297	2403297	+	Nonsense_Mutation	SNP	G	G	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr7:2403297G>T	ENST00000360876.4	+	5	957	c.901G>T	c.(901-903)Gaa>Taa	p.E301*	EIF3B_ENST00000397011.2_Nonsense_Mutation_p.E301*	NM_001037283.1	NP_001032360.1	P55884	EIF3B_HUMAN	eukaryotic translation initiation factor 3, subunit B	301	Sufficient for interaction with EIF3E.				regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity			breast(2)|endometrium(4)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|skin(1)	24		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)		TGAAGAGGCAGAATGCAGAGA	0.373000													23	23					4.26978e-12	4.90825e-12	1	1	0
GADD45GIP1	90480	broad.mit.edu	37	19	13065216	13065216	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr19:13065216C>T	ENST00000316939.1	-	2	498	c.475G>A	c.(475-477)Gag>Aag	p.E159K		NM_052850.3	NP_443082.2	Q8TAE8	G45IP_HUMAN	growth arrest and DNA-damage-inducible, gamma interacting protein 1	159					cell cycle|interspecies interaction between organisms	nucleus	protein binding			ovary(2)|prostate(1)|skin(1)	4						TCCTGGGCCTCAGCCTGCAGT	0.632000													24	163					0	0	1	0	0
ATP6V0A2	23545	broad.mit.edu	37	12	124221774	124221774	+	Missense_Mutation	SNP	G	G	A	rs144949442	byFrequency	TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr12:124221774G>A	ENST00000330342.3	+	9	1242	c.994G>A	c.(994-996)Gag>Aag	p.E332K		NM_012463.3	NP_036595.2	Q9Y487	VPP2_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a2	332					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|immune response|insulin receptor signaling pathway|transferrin transport	endosome membrane|integral to membrane|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity|protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|liver(1)|lung(10)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	26	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000224)|Epithelial(86;0.000625)|all cancers(50;0.00775)		CTGGTGTCCCGAGGCGGATCT	0.552000													8	40					0	0	1	0	0
SIGLEC11	114132	broad.mit.edu	37	19	50463852	50463852	+	Silent	SNP	C	C	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr19:50463852C>A	ENST00000447370.2	-	2	507	c.417G>T	c.(415-417)gtG>gtT	p.V139V	SIGLEC11_ENST00000426971.2_Silent_p.V139V	NM_052884.2	NP_443116.2	Q96RL6	SIG11_HUMAN	sialic acid binding Ig-like lectin 11	139					cell adhesion	integral to membrane	sugar binding	p.V127V(1)		breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(9)|ovary(6)|pancreas(1)|prostate(1)|skin(1)	32		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00107)|OV - Ovarian serous cystadenocarcinoma(262;0.00517)		AACTATGTCTCACACGGCTTC	0.567000													36	11					3.43241e-23	4.03042e-23	1	1	0
ZNF860	344787	broad.mit.edu	37	3	32031691	32031691	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr3:32031691G>A	ENST00000360311.4	+	2	1669	c.1120G>A	c.(1120-1122)Gag>Aag	p.E374K		NM_001137674.2	NP_001131146.2	A6NHJ4	ZN860_HUMAN	zinc finger protein 860	374					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|lung(4)|ovary(1)	8						CAAGTGTAATGAGTGTGGCAA	0.393000													10	31					0	0	1	0	0
GLIPR1L1	256710	broad.mit.edu	37	12	75728517	75728517	+	Silent	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr12:75728517G>A	ENST00000312442.2	+	1	55	c.9G>A	c.(7-9)ctG>ctA	p.L3L	GLIPR1L1_ENST00000378695.4_Silent_p.L3L|CAPS2_ENST00000442339.2_Intron	NM_152779.2	NP_689992.1	Q6UWM5	GPRL1_HUMAN	GLI pathogenesis-related 1 like 1	3						extracellular region				endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)|skin(1)	10						CCATGGCTCTGAAGAATAAAT	0.527000											OREG0021998	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	24					0	0	1	0	0
KRT71	112802	broad.mit.edu	37	12	52943969	52943969	+	Missense_Mutation	SNP	T	T	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr12:52943969T>C	ENST00000267119.5	-	2	569	c.500A>G	c.(499-501)cAg>cGg	p.Q167R		NM_033448.2	NP_258259.1	Q3SY84	K2C71_HUMAN	keratin 71	167	Linker 1.|Rod.						structural molecule activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.194)		CAGGTCCAGCTGCTGCAGCAG	0.582000													38	30					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133489529	133489529	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr2:133489529G>C	ENST00000409261.1	-	17	5597	c.5224C>G	c.(5224-5226)Cca>Gca	p.P1742A	NCKAP5_ENST00000473859.1_5'UTR|NCKAP5_ENST00000409213.1_Missense_Mutation_p.P423A|NCKAP5_ENST00000317721.6_Missense_Mutation_p.P1742A|NCKAP5_ENST00000405974.3_Missense_Mutation_p.P423A	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	1742							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						GGGGAGTCTGGCTGGCATAGG	0.557000													8	42					0	0	1	0	0
EXOC4	60412	broad.mit.edu	37	7	133164868	133164868	+	Missense_Mutation	SNP	T	T	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr7:133164868T>A	ENST00000253861.4	+	9	1422	c.1393T>A	c.(1393-1395)Tat>Aat	p.Y465N	EXOC4_ENST00000393161.2_Missense_Mutation_p.Y465N|EXOC4_ENST00000539845.1_Missense_Mutation_p.Y364N	NM_021807.3	NP_068579.3	Q96A65	EXOC4_HUMAN	exocyst complex component 4	465					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(16)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	50		Esophageal squamous(399;0.129)				AAGGGAGCTCTATAGTCGGAG	0.463000													20	32					0	0	1	0	0
SLIT1	6585	broad.mit.edu	37	10	98802704	98802704	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr10:98802704C>G	ENST00000266058.4	-	20	2363	c.2118G>C	c.(2116-2118)caG>caC	p.Q706H	ARHGAP19-SLIT1_ENST00000453547.2_3'UTR|SLIT1_ENST00000371070.4_Missense_Mutation_p.Q706H	NM_003061.2	NP_003052.2	O75093	SLIT1_HUMAN	slit homolog 1 (Drosophila)	706	LRRCT 3.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(37)|ovary(5)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	78		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		GCAGGGGAATCTGCCGCAAAA	0.632000													8	21					0	0	1	0	0
ZNF513	130557	broad.mit.edu	37	2	27600946	27600946	+	Silent	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr2:27600946G>A	ENST00000323703.6	-	4	1290	c.1092C>T	c.(1090-1092)ctC>ctT	p.L364L	ZNF513_ENST00000491924.1_Intron|ZNF513_ENST00000407879.1_Silent_p.L302L	NM_144631.5	NP_653232.3	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	364					regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding			endometrium(5)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)	17	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAAAGGGGCAGAGGCTACAGG	0.647000													70	61					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100395368	100395368	+	RNA	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr7:100395368G>C	ENST00000542585.1	+	0	8663				ZAN_ENST00000421100.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000443370.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			GCTCAGTTTTGAGCTGTCTTC	0.438000													15	36					0	0	1	0	0
USP11	8237	broad.mit.edu	37	X	47104311	47104311	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chrX:47104311G>A	ENST00000377107.2	+	15	2428	c.2074G>A	c.(2074-2076)Gaa>Aaa	p.E692K	USP11_ENST00000218348.3_Missense_Mutation_p.E735K			P51784	UBP11_HUMAN	ubiquitin specific peptidase 11	735					protein deubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(14)|ovary(3)|pancreas(1)|stomach(1)	40						AACCTCCCCTGAAGAAGTCCA	0.607000													18	12					0	0	1	0	0
PRUNE	58497	broad.mit.edu	37	1	150991007	150991007	+	Missense_Mutation	SNP	G	G	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr1:150991007G>T	ENST00000271620.3	+	3	353	c.197G>T	c.(196-198)cGa>cTa	p.R66L	PRUNE_ENST00000368936.1_Intron|PRUNE_ENST00000271619.8_Intron|PRUNE_ENST00000368935.1_Intron|PRUNE_ENST00000368937.1_Intron|PRUNE_ENST00000467771.1_Intron	NM_021222.1	NP_067045.1	Q86TP1	PRUNE_HUMAN	prune exopolyphosphatase	66						cytoplasm|focal adhesion|nucleus	inorganic diphosphatase activity|manganese ion binding|protein binding			NS(1)|breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	14	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CTACCTCTGCGAGGTGACATT	0.408000													27	22					2.2171e-23	2.6096e-23	1	1	0
NOTCH3	4854	broad.mit.edu	37	19	15302808	15302808	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr19:15302808C>G	ENST00000263388.2	-	4	717	c.642G>C	c.(640-642)caG>caC	p.Q214H		NM_000435.2	NP_000426.2	Q9UM47	NOTC3_HUMAN	notch 3	214	EGF-like 5.				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(4)|central_nervous_system(3)|endometrium(10)|kidney(3)|large_intestine(16)|liver(1)|lung(31)|ovary(8)|prostate(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	93			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			GGTCGCCACTCTGCCTGCAGG	0.657000													3	23					0	0	1	0	0
CSPP1	79848	broad.mit.edu	37	8	67986500	67986500	+	Missense_Mutation	SNP	T	T	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr8:67986500T>A	ENST00000262210.5	+	2	152	c.121T>A	c.(121-123)Ttg>Atg	p.L41M	CSPP1_ENST00000412460.1_5'UTR|COPS5_ENST00000519963.1_Intron	NM_024790.6	NP_079066.5	Q1MSJ5	CSPP1_HUMAN	centrosome and spindle pole associated protein 1	41						centrosome|microtubule|spindle				NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(17)|ovary(5)|prostate(3)|skin(1)|urinary_tract(1)	49	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			GGCTGATAATTTGGATGAATT	0.333000													8	33					0	0	1	0	0
ZNF689	115509	broad.mit.edu	37	16	30615768	30615768	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr16:30615768C>G	ENST00000287461.3	-	3	1657	c.1320G>C	c.(1318-1320)caG>caC	p.Q440H	RP11-146F11.5_ENST00000563540.1_RNA	NM_138447.1	NP_612456.1	Q96CS4	ZN689_HUMAN	zinc finger protein 689	440					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|prostate(1)|urinary_tract(1)	14			Colorectal(24;0.198)			GGTGGCTCCACTGAGCAAAAC	0.677000													9	16					0	0	1	0	0
SCML2	10389	broad.mit.edu	37	X	18265988	18265988	+	Missense_Mutation	SNP	T	T	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chrX:18265988T>A	ENST00000251900.4	-	12	1630	c.1471A>T	c.(1471-1473)Aca>Tca	p.T491S	SCML2_ENST00000398048.3_Missense_Mutation_p.T227S	NM_006089.2	NP_006080.1	Q9UQR0	SCML2_HUMAN	sex comb on midleg-like 2 (Drosophila)	491					anatomical structure morphogenesis	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	36	Hepatocellular(33;0.183)					TGCCTTTCTGTTACATCTTCT	0.383000													7	13					0	0	1	0	0
PDE6C	5146	broad.mit.edu	37	10	95422892	95422892	+	Silent	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr10:95422892C>T	ENST00000371447.3	+	21	2613	c.2475C>T	c.(2473-2475)gtC>gtT	p.V825V	PDE6C_ENST00000475427.2_Intron	NM_006204.3	NP_006195.3	P51160	PDE6C_HUMAN	phosphodiesterase 6C, cGMP-specific, cone, alpha prime	825					visual perception	plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|metal ion binding			breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(12)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	42		Colorectal(252;0.123)				AGATGAAGGTCATTGAAGAGG	0.433000													9	10					0	0	1	0	0
VPS8	23355	broad.mit.edu	37	3	184567805	184567805	+	Missense_Mutation	SNP	A	A	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr3:184567805A>G	ENST00000287546.4	+	9	919	c.748A>G	c.(748-750)Atc>Gtc	p.I250V	VPS8_ENST00000446204.2_Missense_Mutation_p.I248V|VPS8_ENST00000436792.2_Missense_Mutation_p.I248V|VPS8_ENST00000437079.3_Missense_Mutation_p.I250V	NM_015303.3	NP_056118.2	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog (S. cerevisiae)	250							zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(11)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	54	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			AATATTGCATATCAAGGTAAG	0.328000													15	18					0	0	1	0	0
GALNT8	26290	broad.mit.edu	37	12	4830023	4830023	+	Silent	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr12:4830023C>G	ENST00000252318.2	+	1	517	c.180C>G	c.(178-180)ctC>ctG	p.L60L	RP11-234B24.6_ENST00000544741.2_Intron	NM_017417.1	NP_059113.1	Q9NY28	GALT8_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)	60						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	35						TAAAGAGACTCTCCCACTTGG	0.473000													23	29					0	0	1	0	0
NCF2	4688	broad.mit.edu	37	1	183532664	183532664	+	Silent	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr1:183532664C>G	ENST00000413720.1	-	11	1222	c.948G>C	c.(946-948)acG>acC	p.T316T	NCF2_ENST00000469280.1_5'UTR|NCF2_ENST00000367536.1_Silent_p.T361T|NCF2_ENST00000418089.1_Silent_p.T280T|NCF2_ENST00000367535.3_Silent_p.T361T	NM_001190794.1	NP_001177723.1	P19878	NCF2_HUMAN	neutrophil cytosolic factor 2	361					cellular defense response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex|nucleolus	electron carrier activity|protein C-terminus binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	30						TCATGACTACCGTGTACTTGT	0.552000													12	163					0	0	1	0	0
TUFM	7284	broad.mit.edu	37	16	28855329	28855329	+	Missense_Mutation	SNP	C	C	T	rs121434452		TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr16:28855329C>T	ENST00000313511.3	-	8	1154	c.1016G>A	c.(1015-1017)cGg>cAg	p.R339Q		NM_003321.4	NP_003312.3	P49411	EFTU_HUMAN	Tu translation elongation factor, mitochondrial	336						mitochondrial nucleoid	GTP binding|GTPase activity|protein binding|translation elongation factor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	13						GACCAGGCCCCGCCGCAAGTC	0.647000													9	26					0	0	1	0	0
WDR6	11180	broad.mit.edu	37	3	49051451	49051451	+	Silent	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr3:49051451C>T	ENST00000395474.3	+	2	2854	c.2574C>T	c.(2572-2574)ctC>ctT	p.L858L	WDR6_ENST00000608424.1_Silent_p.L828L|WDR6_ENST00000448293.1_Silent_p.L777L|WDR6_ENST00000415265.2_Silent_p.L276L	NM_018031.3	NP_060501.3	Q9NNW5	WDR6_HUMAN	WD repeat domain 6	828					cell cycle arrest|negative regulation of cell proliferation	cytoplasm				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(1)|liver(1)|lung(9)|ovary(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	26				Kidney(197;9.12e-07)|KIRC - Kidney renal clear cell carcinoma(197;1.32e-05)|BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000155)		CAAGCCGCCTCGCCTGCCATG	0.617000											OREG0015565	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	30	41					0	0	1	0	0
PRDM15	63977	broad.mit.edu	37	21	43298917	43298917	+	Silent	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr21:43298917G>A	ENST00000269844.3	-	3	410	c.300C>T	c.(298-300)gtC>gtT	p.V100V	PRDM15_ENST00000422911.1_Intron|PRDM15_ENST00000538201.1_Intron|PRDM15_ENST00000398548.1_Intron	NM_022115.3	NP_071398.3	P57071	PRD15_HUMAN	PR domain containing 15	100					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(11)|ovary(3)|skin(2)|stomach(2)|urinary_tract(1)	43						CCTCGGCGACGAcgccgcccg	0.821000													3	4					0	0	1	0	0
HLA-DQB2	3120	broad.mit.edu	37	6	32725559	32725559	+	Missense_Mutation	SNP	C	C	T	rs113761247	byFrequency	TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr6:32725559C>T	ENST00000435145.2	-	4	809	c.748G>A	c.(748-750)Ggt>Agt	p.G250S	HLA-DQB2_ENST00000411527.1_Intron|HLA-DQB2_ENST00000437316.2_Missense_Mutation_p.G250S			Q5SR06	Q5SR06_HUMAN	major histocompatibility complex, class II, DQ beta 2	216					antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|immune response	integral to membrane|MHC class II protein complex				endometrium(1)|kidney(1)|lung(1)|prostate(2)	5						CCTTTCTGACCCCTGTGACGG	0.552000													5	21					0	0	1	0	0
SKAP1	8631	broad.mit.edu	37	17	46474067	46474067	+	Missense_Mutation	SNP	G	G	A	rs116549994	by1000genomes	TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr17:46474067G>A	ENST00000336915.6	-	2	196	c.127C>T	c.(127-129)Cgg>Tgg	p.R43W	SKAP1_ENST00000584924.1_Missense_Mutation_p.R43W	NM_001075099.1|NM_003726.3	NP_001068567.1|NP_003717.3	Q86WV1	SKAP1_HUMAN	src kinase associated phosphoprotein 1	43					positive regulation of transcription from RNA polymerase II promoter|T cell receptor signaling pathway	cytoplasm|nucleus|plasma membrane	antigen binding|protein kinase binding|SH2 domain binding			large_intestine(1)|lung(10)|prostate(2)|skin(4)|urinary_tract(1)	18						TGAAAGCCCCGTAGAATATGG	0.378000													7	87					0	0	1	0	0
RGS12	6002	broad.mit.edu	37	4	3422404	3422404	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr4:3422404G>C	ENST00000336727.3	+	10	3701	c.2797G>C	c.(2797-2799)Gag>Cag	p.E933Q	RGS12_ENST00000538395.1_Missense_Mutation_p.E275Q|RGS12_ENST00000344733.5_Missense_Mutation_p.E933Q|RGS12_ENST00000338806.4_Missense_Mutation_p.E285Q|RGS12_ENST00000382788.3_Missense_Mutation_p.E933Q|RGS12_ENST00000508158.1_3'UTR|RGS12_ENST00000306648.7_Missense_Mutation_p.E331Q	NM_002926.3	NP_002917.1	O14924	RGS12_HUMAN	regulator of G-protein signaling 12	933						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity	p.E933K(1)		autonomic_ganglia(1)|breast(4)|endometrium(3)|kidney(2)|large_intestine(9)|lung(16)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GTGTCGCCGAGAGTCGCAGGG	0.602000													3	29					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56469908	56469908	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr6:56469908C>T	ENST00000370754.5	-	39	9418	c.9419G>A	c.(9418-9420)gGa>gAa	p.G3140E	DST_ENST00000361203.3_Missense_Mutation_p.G2962E|DST_ENST00000370788.2_Intron|DST_ENST00000312431.6_Missense_Mutation_p.G2962E|DST_ENST00000244364.6_Intron|DST_ENST00000421834.2_Intron|DST_ENST00000370769.4_Missense_Mutation_p.G2962E|DST_ENST00000446842.2_Missense_Mutation_p.G2636E			Q03001	DYST_HUMAN	dystonin	2962					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TTTCTCAGGTCCATCAGTGAA	0.358000													4	12					0	0	1	0	0
SLC25A10	1468	broad.mit.edu	37	17	79674001	79674001	+	Silent	SNP	G	G	A	rs149365217		TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr17:79674001G>A	ENST00000571730.1	+	4	542	c.411G>A	c.(409-411)gcG>gcA	p.A137A	SLC25A10_ENST00000541223.1_Silent_p.A137A|MRPL12_ENST00000333676.3_Silent_p.A137A			Q9UBX3	DIC_HUMAN	solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10	0					gluconeogenesis|mitochondrial transport	integral to membrane|mitochondrial inner membrane|nucleus	protein binding	p.A137A(1)		endometrium(1)|lung(9)|ovary(1)|prostate(1)|skin(2)	14	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0117)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)		Succinic acid(DB00139)	TGACCGAGGCGAAGCCCGTGG	0.567000													3	26					0	0	1	0	0
ERBB3	2065	broad.mit.edu	37	12	56482537	56482537	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr12:56482537G>A	ENST00000267101.3	+	9	1434	c.994G>A	c.(994-996)Gag>Aag	p.E332K	ERBB3_ENST00000415288.2_Missense_Mutation_p.E273K|ERBB3_ENST00000450146.2_Intron	NM_001982.3	NP_001973.2	P21860	ERBB3_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3	332					cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity	p.E332K(2)		central_nervous_system(2)|lung(3)|ovary(1)|skin(1)|stomach(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			TGCAGCCTGTGAGGGAACAGG	0.522000													44	39					0	0	1	0	0
SEZ6	124925	broad.mit.edu	37	17	27287864	27287864	+	Silent	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr17:27287864G>A	ENST00000317338.12	-	6	1796	c.1368C>T	c.(1366-1368)caC>caT	p.H456H	SEZ6_ENST00000360295.9_Silent_p.H456H|PIPOX_ENST00000583215.1_Intron|SEZ6_ENST00000335960.6_Silent_p.H456H|SEZ6_ENST00000442608.3_Silent_p.H456H			Q53EL9	SEZ6_HUMAN	seizure related 6 homolog (mouse)	456	CUB 1.					integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(4)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	29	Lung NSC(42;0.0137)		Epithelial(11;4.73e-06)|all cancers(11;2.91e-05)|BRCA - Breast invasive adenocarcinoma(11;8.06e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.111)			CAAAGTGCAGGTGTAGCCGCT	0.607000													52	82					0	0	1	0	0
ADCY8	114	broad.mit.edu	37	8	132051646	132051646	+	Silent	SNP	G	G	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr8:132051646G>T	ENST00000286355.5	-	1	3026	c.934C>A	c.(934-936)Cgg>Agg	p.R312R	ADCY8_ENST00000377928.3_Silent_p.R312R	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	312					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			ACCGCCAGCCGGGGTATGACC	0.587000										HNSCC(32;0.087)			9	76					3.09899e-07	3.35837e-07	1	1	0
MINK1	50488	broad.mit.edu	37	17	4800081	4800081	+	Silent	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr17:4800081C>G	ENST00000355280.6	+	31	4084	c.3888C>G	c.(3886-3888)ctC>ctG	p.L1296L	MINK1_ENST00000453408.3_Silent_p.L1276L|MINK1_ENST00000347992.7_Silent_p.L1267L	NM_001024937.3|NM_015716.4|NM_153827.4	NP_001020108.1|NP_056531.1|NP_722549.2	Q8N4C8	MINK1_HUMAN	misshapen-like kinase 1	1296	CNH.|Mediates interaction with RAP2A.				JNK cascade	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)|stomach(1)	6						CTCAGAGGCTCAAGTTCCTGT	0.597000													3	16					0	0	1	0	0
DIP2A	23181	broad.mit.edu	37	21	47969718	47969718	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr21:47969718G>A	ENST00000318711.7	+	22	2743	c.2560G>A	c.(2560-2562)Gac>Aac	p.D854N	DIP2A_ENST00000457905.3_Missense_Mutation_p.D853N|DIP2A_ENST00000417564.2_Missense_Mutation_p.D853N|DIP2A_ENST00000400274.1_Missense_Mutation_p.D849N|DIP2A_ENST00000427143.2_Missense_Mutation_p.D789N	NM_001146116.1|NM_015151.3	NP_001139588.1|NP_055966.2	Q14689	DIP2A_HUMAN	DIP2 disco-interacting protein 2 homolog A (Drosophila)	853					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			cervix(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(22)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		GCTGCACGACGACCGGATTGT	0.627000													63	172					0	0	1	0	0
ZNF737	100129842	broad.mit.edu	37	19	20728173	20728173	+	Missense_Mutation	SNP	T	T	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr19:20728173T>C	ENST00000427401.4	-	4	930	c.836A>G	c.(835-837)cAt>cGt	p.H279R		NM_001159293.1	NP_001152765.1	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	279					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(2)|kidney(1)|lung(7)|ovary(1)|stomach(1)|urinary_tract(1)	13						CTCTCCAGTATGAATTATCTT	0.418000													4	13					0	0	1	0	0
ZFYVE9	9372	broad.mit.edu	37	1	52811739	52811739	+	Missense_Mutation	SNP	A	A	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr1:52811739A>G	ENST00000287727.3	+	19	4296	c.4124A>G	c.(4123-4125)tAt>tGt	p.Y1375C	ZFYVE9_ENST00000357206.2_Missense_Mutation_p.Y1316C|ZFYVE9_ENST00000371591.1_Missense_Mutation_p.Y1375C			O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9	1375					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			breast(1)|central_nervous_system(4)|endometrium(3)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	53						TAGGTTGGCTATCAAGCAGGG	0.567000													7	58					0	0	1	0	0
MED1	5469	broad.mit.edu	37	17	37565285	37565285	+	Silent	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr17:37565285G>A	ENST00000300651.6	-	17	3412	c.3189C>T	c.(3187-3189)atC>atT	p.I1063I	MED1_ENST00000394287.3_Intron	NM_004774.3	NP_004765.2	Q15648	MED1_HUMAN	mediator complex subunit 1	1063	Interaction with ESR1.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			NS(1)|breast(2)|cervix(3)|kidney(3)|large_intestine(7)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(7)|urinary_tract(1)	59		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		TCTGAATAGTGATTTTGGGAA	0.517000										HNSCC(31;0.082)			29	44					0	0	1	0	0
MBD5	55777	broad.mit.edu	37	2	149227513	149227513	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr2:149227513G>C	ENST00000407073.1	+	9	2998	c.2001G>C	c.(1999-2001)ttG>ttC	p.L667F	MBD5_ENST00000404807.1_Missense_Mutation_p.L667F	NM_018328.4	NP_060798.2	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	667						chromosome|nucleus	chromatin binding|DNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(16)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	62				BRCA - Breast invasive adenocarcinoma(221;0.0569)		CGACAGTGTTGAGTTTGCTCA	0.468000													36	87					0	0	1	0	0
ZNF787	126208	broad.mit.edu	37	19	56600221	56600221	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr19:56600221G>A	ENST00000270459.3	-	3	438	c.320C>T	c.(319-321)tCg>tTg	p.S107L		NM_001002836.2	NP_001002836	Q6DD87	ZN787_HUMAN	zinc finger protein 787	107					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|lung(2)|pancreas(1)	5		Colorectal(82;3.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0559)		CACCAGGTGCGAGCTCTGCGA	0.672000													23	3					0	0	1	0	0
THNSL1	79896	broad.mit.edu	37	10	25312524	25312524	+	Silent	SNP	A	A	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr10:25312524A>T	ENST00000524413.1	+	3	719	c.372A>T	c.(370-372)gcA>gcT	p.A124A	THNSL1_ENST00000376356.4_Silent_p.A124A			Q8IYQ7	THNS1_HUMAN	threonine synthase-like 1 (S. cerevisiae)	124					threonine biosynthetic process		ATP binding|pyridoxal phosphate binding|shikimate kinase activity|threonine synthase activity			NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(5)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	28					L-Threonine(DB00156)|Pyridoxal Phosphate(DB00114)	ACTTCTCTGCATCTGGAAGTG	0.383000													13	27					0	0	1	0	0
GFRA1	2674	broad.mit.edu	37	10	117856175	117856175	+	Missense_Mutation	SNP	C	C	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr10:117856175C>A	ENST00000439649.3	-	6	1223	c.856G>T	c.(856-858)Ggg>Tgg	p.G286W	GFRA1_ENST00000544592.1_Missense_Mutation_p.G170W|GFRA1_ENST00000355422.6_Missense_Mutation_p.G291W|GFRA1_ENST00000369236.1_Missense_Mutation_p.G286W	NM_001145453.1	NP_001138925.1	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1	291					axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			endometrium(2)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)	26		Lung NSC(174;0.21)		all cancers(201;0.0337)		CCAATAAGCCCCGAGTAGGCG	0.507000													4	11					0.014758	0.0150019	1	1	0
SH3BP4	23677	broad.mit.edu	37	2	235951148	235951148	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr2:235951148C>G	ENST00000409212.1	+	4	2242	c.1735C>G	c.(1735-1737)Cag>Gag	p.Q579E	SH3BP4_ENST00000344528.4_Missense_Mutation_p.Q579E|SH3BP4_ENST00000392011.2_Missense_Mutation_p.Q579E			Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	579					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(6)|stomach(3)|urinary_tract(2)	44		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		CATCACCTCCCAGAACCCCAA	0.592000													5	45					0	0	1	0	0
ADRA1D	146	broad.mit.edu	37	20	4202244	4202244	+	Nonsense_Mutation	SNP	C	C	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr20:4202244C>A	ENST00000379453.4	-	2	1761	c.1645G>T	c.(1645-1647)Gag>Tag	p.E549*		NM_000678.3	NP_000669.1	P25100	ADA1D_HUMAN	adrenoceptor alpha 1D	549				KPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRA EAACAQRSEVEAVSLGVPHEVAEGATCQAYELADYSNLRET DI -> SHPAPSASGGCWGRSGDPRPSCAPKSPACRTRSPP GARSAQRQRAPSAQRWRLCP (in Ref. 1).	cell proliferation|cell-cell signaling|DNA metabolic process|G-protein signaling, coupled to cAMP nucleotide second messenger|multicellular organismal development|positive regulation of cell proliferation	integral to plasma membrane	alpha1-adrenergic receptor activity			endometrium(1)|large_intestine(2)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	14					Alfuzosin(DB00346)|Bethanidine(DB00217)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Doxazosin(DB00590)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Methotrimeprazine(DB01403)|Norepinephrine(DB00368)|Promazine(DB00420)|Propericiazine(DB01608)|Propiomazine(DB00777)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)	TCGGCCACCTCGTGTGGGACG	0.682000													11	29					2.27111e-07	2.47209e-07	1	1	0
UMOD	7369	broad.mit.edu	37	16	20352498	20352498	+	Nonsense_Mutation	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr16:20352498G>A	ENST00000396134.2	-	8	1714	c.1591C>T	c.(1591-1593)Cga>Tga	p.R531*	UMOD_ENST00000396138.4_Nonsense_Mutation_p.R547*|UMOD_ENST00000424589.1_Nonsense_Mutation_p.R531*|UMOD_ENST00000570689.1_Nonsense_Mutation_p.R498*|UMOD_ENST00000302509.4_Nonsense_Mutation_p.R498*|UMOD_ENST00000396142.2_Nonsense_Mutation_p.R498*|UMOD_ENST00000570331.1_5'UTR	NM_001278614.1	NP_001265543.1	P07911	UROM_HUMAN	uromodulin	498	ZP.				cellular defense response|negative regulation of cell proliferation	anchored to membrane|apical plasma membrane|basolateral plasma membrane|cilium membrane|extrinsic to membrane|primary cilium|spindle pole	calcium ion binding			endometrium(5)|kidney(1)|large_intestine(7)|lung(20)|ovary(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	41						AGTGCAAATCGGGACAGGTCG	0.567000													7	34					0	0	1	0	0
ULK1	8408	broad.mit.edu	37	12	132402081	132402081	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr12:132402081C>T	ENST00000321867.4	+	22	2659	c.2308C>T	c.(2308-2310)Cgc>Tgc	p.R770C		NM_003565.2	NP_003556	O75385	ULK1_HUMAN	unc-51 like autophagy activating kinase 1	770					autophagy|protein localization|regulation of autophagy	autophagic vacuole|cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	ATP binding|protein complex binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|prostate(2)|skin(2)|urinary_tract(2)	29	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.07e-08)|Epithelial(86;2.56e-07)|all cancers(50;3.01e-07)		CCAGGGCCCCCGCACCAGGAT	0.706000													4	10					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56470221	56470221	+	Nonsense_Mutation	SNP	C	C	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr6:56470221C>A	ENST00000370754.5	-	39	9105	c.9106G>T	c.(9106-9108)Gaa>Taa	p.E3036*	DST_ENST00000361203.3_Nonsense_Mutation_p.E2858*|DST_ENST00000370788.2_Intron|DST_ENST00000312431.6_Nonsense_Mutation_p.E2858*|DST_ENST00000244364.6_Intron|DST_ENST00000421834.2_Intron|DST_ENST00000370769.4_Nonsense_Mutation_p.E2858*|DST_ENST00000446842.2_Nonsense_Mutation_p.E2532*			Q03001	DYST_HUMAN	dystonin	2858					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TGCCTATTTTCTTCTTCTACT	0.338000													9	15					7.48243e-07	8.07315e-07	1	1	0
SYNJ2	8871	broad.mit.edu	37	6	158504508	158504508	+	Silent	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr6:158504508G>A	ENST00000355585.4	+	21	2988	c.2913G>A	c.(2911-2913)ctG>ctA	p.L971L	SYNJ2_ENST00000367122.2_Silent_p.L971L|SYNJ2_ENST00000367121.3_Silent_p.L971L|SYNJ2_ENST00000367112.1_Silent_p.L56L	NM_001178088.1|NM_003898.3	NP_001171559.1|NP_003889.1	O15056	SYNJ2_HUMAN	synaptojanin 2	971							nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			biliary_tract(1)|endometrium(9)|kidney(3)|large_intestine(11)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		AGGACTGGCTGAAAGGTTTGC	0.522000													6	37					0	0	1	0	0
SNORD114-27	767608	broad.mit.edu	37	14	101454556	101454556	+	RNA	SNP	T	T	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr14:101454556T>C	ENST00000363766.1	+	0	59					NR_003220.1																						TGTCTGGAACTCTGAGGCCCA	0.378000													7	43					0	0	1	0	0
NCKAP5L	57701	broad.mit.edu	37	12	50189721	50189721	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr12:50189721G>A	ENST00000335999.6	-	8	2123	c.1922C>T	c.(1921-1923)tCa>tTa	p.S641L		NM_001037806.3	NP_001032895.2	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	637										central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(8)|prostate(2)	18						CTTCTTGGATGAGTTGCCTGG	0.652000													7	5					0	0	1	0	0
DSG3	1830	broad.mit.edu	37	18	29027853	29027853	+	Missense_Mutation	SNP	T	T	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr18:29027853T>A	ENST00000257189.4	+	1	96	c.13T>A	c.(13-15)Ttc>Atc	p.F5I		NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3	5					cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			GATGGGGCTCTTCCCCAGAAC	0.473000													6	11					0	0	1	0	0
MYO19	80179	broad.mit.edu	37	17	34862865	34862865	+	Silent	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr17:34862865G>A	ENST00000431794.3	-	17	2103	c.1581C>T	c.(1579-1581)ttC>ttT	p.F527F	MYO19_ENST00000268852.9_Intron	NM_001163735.1	NP_001157207.1	Q96H55	MYO19_HUMAN	myosin XIX	527	Myosin head-like.					mitochondrial outer membrane|myosin complex	actin binding|ATP binding|motor activity			endometrium(6)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|urinary_tract(1)	20		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		GCACCACAATGAAGCTGGGCT	0.642000													8	21					0	0	1	0	0
WSCD2	9671	broad.mit.edu	37	12	108620796	108620796	+	Silent	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr12:108620796C>T	ENST00000332082.4	+	7	1652	c.834C>T	c.(832-834)acC>acT	p.T278T	WSCD2_ENST00000261400.3_Silent_p.T278T|WSCD2_ENST00000547525.1_Silent_p.T278T|WSCD2_ENST00000549903.1_Silent_p.T278T			Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	278	WSC 2.					integral to membrane				breast(4)|endometrium(3)|kidney(1)|large_intestine(16)|liver(2)|lung(23)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	57						TTGCAGGCACCGCCTGCCACT	0.582000													5	47					0	0	1	0	0
CD300LG	146894	broad.mit.edu	37	17	41926218	41926218	+	Silent	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr17:41926218G>C	ENST00000317310.4	+	2	377	c.336G>C	c.(334-336)cgG>cgC	p.R112R	CD300LG_ENST00000377203.4_Silent_p.R112R|CD300LG_ENST00000293396.8_Silent_p.R112R|CD300LG_ENST00000539718.1_Silent_p.R112R|CD300LG_ENST00000586233.1_Silent_p.R112R|CD300LG_ENST00000588884.1_Silent_p.R112R	NM_145273.3	NP_660316.2	Q6UXG3	CLM9_HUMAN	CD300 molecule-like family member g	112	Ig-like V-type.					apical plasma membrane|basolateral plasma membrane|integral to membrane|multivesicular body membrane	receptor activity			central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(2)|lung(5)|skin(4)	19		Breast(137;0.0199)		BRCA - Breast invasive adenocarcinoma(366;0.115)		TCGAAAAACGGGGCCCCGATG	0.577000													25	38					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179401884	179401884	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr2:179401884C>T	ENST00000589042.1	-	356	100176	c.99952G>A	c.(99952-99954)Gac>Aac	p.D33318N	TTN-AS1_ENST00000589434.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.D31677N|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.D24445N|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.D24253N|TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000588804.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000431259.2_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.D24378N|TTN-AS1_ENST00000589391.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000588244.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000591867.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.D30750N|TTN-AS1_ENST00000585487.1_RNA|TTN-AS1_ENST00000591466.1_RNA|TTN-AS1_ENST00000585358.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000450692.2_RNA|TTN-AS1_ENST00000588716.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592182.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592836.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	31677	Ig-like 146.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAGCCTCCGTCATCTGCGGGT	0.502000													7	21					0	0	1	0	0
RBM6	10180	broad.mit.edu	37	3	50103753	50103753	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr3:50103753G>A	ENST00000443081.1	+	17	3284	c.2365G>A	c.(2365-2367)Gaa>Aaa	p.E789K	RBM6_ENST00000441115.1_3'UTR|RBM6_ENST00000266022.4_Missense_Mutation_p.E921K|RBM6_ENST00000539992.1_Missense_Mutation_p.E263K|RBM6_ENST00000442092.1_Missense_Mutation_p.E399K|RBM6_ENST00000422955.1_Missense_Mutation_p.E399K			P78332	RBM6_HUMAN	RNA binding motif protein 6	921					RNA processing	nucleus	DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(3)|prostate(1)|skin(4)|urinary_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;6.81e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0084)|Kidney(197;0.00977)		AGAAGAGGAGGAACAGACCCC	0.532000													10	30					0	0	1	0	0
COLQ	8292	broad.mit.edu	37	3	15493152	15493152	+	Silent	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr3:15493152C>T	ENST00000383788.5	-	17	1492	c.1367G>A	c.(1366-1368)tGa>tAa	p.*456*	COLQ_ENST00000603808.1_Silent_p.*457*|COLQ_ENST00000383785.2_3'UTR|COLQ_ENST00000383786.5_Silent_p.*422*|COLQ_ENST00000383781.4_Silent_p.*446*|COLQ_ENST00000435459.2_Silent_p.*446*|COLQ_ENST00000383787.2_Silent_p.*447*	NM_005677.3	NP_005668.2	Q9Y215	COLQ_HUMAN	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	0					acetylcholine catabolic process in synaptic cleft|asymmetric protein localization	basal lamina|cell junction|collagen|extracellular space|synaptic cleft				endometrium(2)|large_intestine(4)|lung(10)|skin(3)	19						TCACGGCCCTCAGGTGAAGTA	0.587000													25	52					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100683873	100683873	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr7:100683873C>G	ENST00000306151.4	+	3	9240	c.9176C>G	c.(9175-9177)gCc>gGc	p.A3059G		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	3059	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					ACGCCAGTGGCCATTCCTGAG	0.493000													38	309					0	0	1	0	0
ARID1B	57492	broad.mit.edu	37	6	157521932	157521932	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr6:157521932G>C	ENST00000346085.5	+	18	4205	c.4204G>C	c.(4204-4206)Gag>Cag	p.E1402Q	ARID1B_ENST00000275248.4_Missense_Mutation_p.E1384Q|ARID1B_ENST00000367148.1_Missense_Mutation_p.E1442Q|ARID1B_ENST00000350026.5_Missense_Mutation_p.E1389Q	NM_020732.3	NP_065783.3	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1389					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			NS(2)|breast(5)|central_nervous_system(4)|endometrium(12)|kidney(4)|large_intestine(11)|lung(30)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(3)	81		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		CCAGCAGCAGGAGATGTACAA	0.607000													24	28					0	0	1	0	0
NSMCE1	197370	broad.mit.edu	37	16	27246561	27246561	+	Missense_Mutation	SNP	A	A	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr16:27246561A>T	ENST00000361439.4	-	3	295	c.196T>A	c.(196-198)Tcc>Acc	p.S66T		NM_145080.3	NP_659547.2	Q8WV22	NSE1_HUMAN	non-SMC element 1 homolog (S. cerevisiae)	66					DNA recombination|DNA repair|intracellular signal transduction	nucleus	zinc ion binding			endometrium(2)|large_intestine(2)|lung(3)	7						ATATACAAGGACTCCAAGACA	0.478000											OREG0023693	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	35					0	0	1	0	0
ITGAV	3685	broad.mit.edu	37	2	187498059	187498059	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr2:187498059G>A	ENST00000261023.3	+	6	863	c.589G>A	c.(589-591)Gac>Aac	p.D197N	ITGAV_ENST00000433736.2_Missense_Mutation_p.D151N|ITGAV_ENST00000374907.3_Intron	NM_002210.3	NP_002201	P06756	ITAV_HUMAN	integrin, alpha V	197					angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		CATCTAGGCTGACAGAGTACT	0.308000													18	23					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57326356	57326356	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr19:57326356C>T	ENST00000326441.9	-	10	3817	c.3454G>A	c.(3454-3456)Gag>Aag	p.E1152K	ZIM2_ENST00000593711.1_Intron|PEG3_ENST00000423103.2_Missense_Mutation_p.E1152K|ZIM2_ENST00000601070.1_Intron|PEG3_ENST00000598410.1_Missense_Mutation_p.E1028K|ZIM2_ENST00000599935.1_Intron|PEG3_ENST00000593695.1_Missense_Mutation_p.E1026K|ZIM2_ENST00000221722.5_Intron|ZIM2_ENST00000391708.3_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	1152					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CTCTGATACTCGCTGATGGAA	0.458000													7	113					0	0	1	0	0
LTV1	84946	broad.mit.edu	37	6	144165737	144165737	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr6:144165737C>G	ENST00000367576.5	+	2	252	c.118C>G	c.(118-120)Cta>Gta	p.L40V	RP3-468K18.5_ENST00000545614.1_3'UTR	NM_032860.3	NP_116249.2	Q96GA3	LTV1_HUMAN	LTV1 homolog (S. cerevisiae)	40										breast(2)|endometrium(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)	13				OV - Ovarian serous cystadenocarcinoma(155;2.72e-06)|GBM - Glioblastoma multiforme(68;0.0372)		CCAGAGGGTTCTATTGCCCAC	0.393000													9	43					0	0	1	0	0
LRRC14	9684	broad.mit.edu	37	8	145746109	145746109	+	Missense_Mutation	SNP	T	T	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr8:145746109T>G	ENST00000292524.1	+	3	963	c.817T>G	c.(817-819)Ttc>Gtc	p.F273V	LRRC14_ENST00000529022.1_Missense_Mutation_p.F273V	NM_001272036.1|NM_014665.2	NP_001258965.1|NP_055480.1	Q15048	LRC14_HUMAN	leucine rich repeat containing 14	273										endometrium(1)|lung(3)|prostate(1)	5	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			CGAGGACAACTTCCGCTACTT	0.627000													8	68					0	0	1	0	0
NKX2-2	4821	broad.mit.edu	37	20	21494282	21494282	+	Missense_Mutation	SNP	C	C	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr20:21494282C>A	ENST00000377142.4	-	1	382	c.26G>T	c.(25-27)gGg>gTg	p.G9V		NM_002509.3	NP_002500.1	O95096	NKX22_HUMAN	NK2 homeobox 2	9					brain development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	chromatin binding|core promoter proximal region DNA binding|transcription coactivator activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(10)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21						GACCGAAAACCCCGTCTTTGT	0.582000													5	56					0.00116845	0.00121538	1	1	0
KIF4B	285643	broad.mit.edu	37	5	154395929	154395929	+	Missense_Mutation	SNP	T	T	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr5:154395929T>A	ENST00000435029.4	+	1	2670	c.2510T>A	c.(2509-2511)cTa>cAa	p.L837Q		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	837	Interaction with PRC1 (By similarity).				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			ATTGCTGACCTACAGCAGAAG	0.443000													20	6					0	0	1	0	0
SEMA3E	9723	broad.mit.edu	37	7	83037734	83037734	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr7:83037734C>T	ENST00000307792.3	-	6	1087	c.620G>A	c.(619-621)gGg>gAg	p.G207E	SEMA3E_ENST00000427262.1_Missense_Mutation_p.G147E	NM_012431.2	NP_036563.1	O15041	SEM3E_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	207	Sema.				axon guidance	extracellular space|membrane	receptor activity			breast(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(19)|ovary(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	51		Medulloblastoma(109;0.109)				GGCCAGTCGCCCCATGCTGCG	0.468000													9	30					0	0	1	0	0
SHB	6461	broad.mit.edu	37	9	38016080	38016080	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr9:38016080G>C	ENST00000377707.3	-	2	1331	c.766C>G	c.(766-768)Ctc>Gtc	p.L256V	SHB_ENST00000377700.4_Missense_Mutation_p.L256V|RP11-613M10.9_ENST00000540557.1_Missense_Mutation_p.L256V	NM_003028.2	NP_003019.2	Q15464	SHB_HUMAN	Src homology 2 domain containing adaptor protein B	256	Mediates interaction with LAT, FAK1, JAK1 and JAK3.				angiogenesis|apoptosis|cell differentiation|signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity			central_nervous_system(2)|endometrium(4)|lung(1)|prostate(1)|skin(1)|soft_tissue(1)|stomach(1)	11		all_epithelial(88;0.122)		GBM - Glioblastoma multiforme(29;3.27e-05)|Lung(182;0.0658)		TTGCTCTTGAGATCATTCTTG	0.522000													58	19					0	0	1	0	0
ZNF366	167465	broad.mit.edu	37	5	71740033	71740033	+	Silent	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr5:71740033C>T	ENST00000318442.5	-	5	2275	c.1785G>A	c.(1783-1785)caG>caA	p.Q595Q		NM_152625.1	NP_689838.1	Q8N895	ZN366_HUMAN	zinc finger protein 366	595					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	35		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		CCCGGCGCTTCTGAGAGAGGT	0.632000													43	11					0	0	1	0	0
NPC1L1	29881	broad.mit.edu	37	7	44555496	44555496	+	Silent	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr7:44555496G>A	ENST00000289547.4	-	19	3838	c.3783C>T	c.(3781-3783)ctC>ctT	p.L1261L	NPC1L1_ENST00000546276.1_Silent_p.L1188L|NPC1L1_ENST00000381160.3_Silent_p.L1234L	NM_013389.2	NP_037521.2	Q9UHC9	NPCL1_HUMAN	NPC1-like 1	1261					cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(7)|lung(27)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	57					Ezetimibe(DB00973)	AGATCTGAATGAGCTGGGCCT	0.607000													22	22					0	0	1	0	0
ZNF189	7743	broad.mit.edu	37	9	104170245	104170245	+	Silent	SNP	T	T	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr9:104170245T>A	ENST00000374861.3	+	3	437	c.153T>A	c.(151-153)acT>acA	p.T51T	ZNF189_ENST00000259395.4_Silent_p.T23T|ZNF189_ENST00000339664.2_Silent_p.T65T	NM_001278231.1|NM_001278232.1|NM_003452.2	NP_001265160.1|NP_001265161.1|NP_003443.2	O75820	ZN189_HUMAN	zinc finger protein 189	65	KRAB.				negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(10)|ovary(2)|prostate(3)|skin(2)|urinary_tract(1)	26		Acute lymphoblastic leukemia(62;0.0559)				AGGAGCCAACTGTAAAACAAG	0.368000													3	7					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78317800	78317800	+	Missense_Mutation	SNP	G	G	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr17:78317800G>T	ENST00000582970.1	+	28	6470	c.6327G>T	c.(6325-6327)agG>agT	p.R2109S	RNF213_ENST00000508628.2_Missense_Mutation_p.R2158S|RNF213_ENST00000336301.6_Missense_Mutation_p.R182S	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			TGCCGTCGAGGAGCTCTTCAG	0.507000													17	27					6.94344e-10	7.85327e-10	1	1	0
FRMPD2	143162	broad.mit.edu	37	10	49392913	49392913	+	Missense_Mutation	SNP	T	T	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr10:49392913T>G	ENST00000374201.3	-	19	2673	c.2371A>C	c.(2371-2373)Aat>Cat	p.N791H	FRMPD2_ENST00000305531.3_Missense_Mutation_p.N766H|FRMPD2_ENST00000407470.4_Missense_Mutation_p.N759H	NM_001018071.3|NM_001042512.2	NP_001018081|NP_001035977.2	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2	791	PDZ 1.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			NS(2)|autonomic_ganglia(2)|breast(5)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(15)|lung(24)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	66				Kidney(211;0.201)		TCTCCCTCATTAATGACAAAC	0.398000													4	24					0	0	1	0	0
OSTC	58505	broad.mit.edu	37	4	109578780	109578780	+	Missense_Mutation	SNP	A	A	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr4:109578780A>T	ENST00000361564.4	+	3	480	c.408A>T	c.(406-408)agA>agT	p.R136S	OSTC_ENST00000512478.2_Missense_Mutation_p.R136S	NM_021227.3	NP_067050.1	Q9NRP0	OSTC_HUMAN	oligosaccharyltransferase complex subunit (non-catalytic)	136						integral to membrane|oligosaccharyltransferase complex				breast(1)|endometrium(1)|large_intestine(1)|lung(3)	6						TCATGGCTAGAGTATTCATGA	0.373000													4	12					0	0	1	0	0
CHSY1	22856	broad.mit.edu	37	15	101718339	101718339	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr15:101718339C>G	ENST00000254190.3	-	3	2138	c.1663G>C	c.(1663-1665)Gag>Cag	p.E555Q	CHSY1_ENST00000543813.1_5'UTR	NM_014918.4	NP_055733.2	Q86X52	CHSS1_HUMAN	chondroitin sulfate synthase 1	555					chondroitin sulfate biosynthetic process	Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(5)|skin(1)	24	Lung NSC(78;0.00217)|all_lung(78;0.00271)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CACGTCTTCTCAAAGTTTCCC	0.423000													7	24					0	0	1	0	0
ANKH	56172	broad.mit.edu	37	5	14716863	14716863	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr5:14716863C>T	ENST00000284268.6	-	9	1423	c.1093G>A	c.(1093-1095)Gaa>Aaa	p.E365K	ANKH_ENST00000535119.1_Missense_Mutation_p.E167K	NM_054027.4	NP_473368.1	Q9HCJ1	ANKH_HUMAN	ANKH inorganic pyrophosphate transport regulator	365					locomotory behavior|regulation of bone mineralization|skeletal system development	integral to plasma membrane|outer membrane	inorganic diphosphate transmembrane transporter activity|inorganic phosphate transmembrane transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(13)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	29						ACACAGAGTTCTGCAAAGGCA	0.433000													25	18					0	0	1	0	0
ZFP28	140612	broad.mit.edu	37	19	57058991	57058991	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr19:57058991C>G	ENST00000301318.3	+	3	486	c.415C>G	c.(415-417)Ctg>Gtg	p.L139V	ZFP28_ENST00000591844.1_Missense_Mutation_p.L139V|AC007228.11_ENST00000596587.1_RNA	NM_020828.1	NP_065879.1	Q8NHY6	ZFP28_HUMAN	ZFP28 zinc finger protein	139	KRAB 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(14)|lung(6)|ovary(1)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	35		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0302)		CTACAGGAACCTGGCATCGCT	0.547000													7	44					0	0	1	0	0
AGPAT4	56895	broad.mit.edu	37	6	161560579	161560579	+	Nonsense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr6:161560579C>T	ENST00000320285.4	-	8	1129	c.917G>A	c.(916-918)tGg>tAg	p.W306*	AGPAT4_ENST00000457520.2_Nonsense_Mutation_p.W144*|AGPAT4_ENST00000366911.5_3'UTR	NM_020133.2	NP_064518.1	Q9NRZ5	PLCD_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 4	306					phospholipid biosynthetic process	integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity|protein binding			endometrium(1)|large_intestine(10)|lung(10)|ovary(2)|skin(2)	25		Breast(66;0.000289)|Ovarian(120;0.0266)|Prostate(117;0.0285)		OV - Ovarian serous cystadenocarcinoma(65;2.23e-17)|BRCA - Breast invasive adenocarcinoma(81;3.58e-05)		CACGAGGGTCCAGGGCCGCCG	0.632000													8	56					0	0	1	0	0
POLRMT	5442	broad.mit.edu	37	19	633453	633453	+	Nonsense_Mutation	SNP	G	G	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr19:633453G>T	ENST00000588649.2	-	1	144	c.60C>A	c.(58-60)tgC>tgA	p.C20*		NM_005035.3	NP_005026.3	O00411	RPOM_HUMAN	polymerase (RNA) mitochondrial (DNA directed)	20					transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			cervix(2)|endometrium(3)|large_intestine(1)|lung(9)|ovary(1)|pancreas(2)|prostate(1)|stomach(1)	20		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCGGGCGGCCGCAAGGCCGTA	0.751000													3	4					0.115264	0.115734	1	1	0
SMTN	6525	broad.mit.edu	37	22	31491441	31491441	+	Splice_Site	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr22:31491441G>A	ENST00000333137.7	+	12	2003	c.1785G>A	c.(1783-1785)atG>atA	p.M595I	SMTN_ENST00000358743.1_Splice_Site_p.M595I|SMTN_ENST00000347557.2_Splice_Site_p.M595I|SMTN_ENST00000404574.1_Splice_Site_p.M194I	NM_001207018.1|NM_134269.2	NP_001193947.1|NP_599031.1	P53814	SMTN_HUMAN	smoothelin	595					muscle organ development|smooth muscle contraction	actin cytoskeleton|cytoplasm	actin binding|structural constituent of muscle			breast(2)|endometrium(2)|large_intestine(5)|lung(9)|ovary(3)|pancreas(1)|prostate(3)	25						TGGACAAGATGGTATAGCCAG	0.577000													48	15					0	0	1	0	0
PKDREJ	10343	broad.mit.edu	37	22	46652983	46652983	+	Missense_Mutation	SNP	C	C	G	rs138967620		TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr22:46652983C>G	ENST00000253255.5	-	1	6236	c.6237G>C	c.(6235-6237)caG>caC	p.Q2079H		NM_006071.1	NP_006062.1	Q9NTG1	PKDRE_HUMAN	polycystin (PKD) family receptor for egg jelly	2079					acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			NS(2)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(4)|kidney(5)|large_intestine(21)|lung(16)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	73		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		GGATGGCCCTCTGAGCCAGGC	0.463000													4	13					0	0	1	0	0
DDX1	1653	broad.mit.edu	37	2	15768964	15768964	+	Splice_Site	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr2:15768964G>A	ENST00000381341.2	+	24	2264		c.e24+1		DDX1_ENST00000233084.3_Splice_Site			Q92499	DDX1_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 1						DNA duplex unwinding|double-strand break repair|multicellular organismal development|regulation of transcription, DNA-dependent|regulation of translational initiation|spliceosome assembly|transcription, DNA-dependent	cleavage body|stress granule|tRNA-splicing ligase complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|DNA/RNA helicase activity|exonuclease activity|poly(A) RNA binding|protein binding|RNA helicase activity|transcription cofactor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(13)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)	all_epithelial(98;2.96e-07)|Acute lymphoblastic leukemia(84;4.24e-05)|Ovarian(717;0.0694)	GBM - Glioblastoma multiforme(3;0.00969)	Epithelial(75;4.35e-05)|OV - Ovarian serous cystadenocarcinoma(76;0.133)		AAAAGAAAAGGTAATCTTTGT	0.338000													17	23					0	0	1	0	0
TBC1D1	23216	broad.mit.edu	37	4	38016420	38016420	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr4:38016420C>G	ENST00000261439.4	+	3	1063	c.708C>G	c.(706-708)ttC>ttG	p.F236L	TBC1D1_ENST00000508802.1_Missense_Mutation_p.F236L	NM_001253914.1|NM_001253915.1|NM_015173.3	NP_001240843.1|NP_001240844.1|NP_055988.2	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	236						nucleus	Rab GTPase activator activity			NS(1)|breast(3)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	36						GCAAGTCCTTCTCCCAGCCCG	0.701000													5	14					0	0	1	0	0
RORB	6096	broad.mit.edu	37	9	77249651	77249651	+	Silent	SNP	A	A	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr9:77249651A>G	ENST00000376896.3	+	3	810	c.198A>G	c.(196-198)cgA>cgG	p.R66R	RORB_ENST00000396204.2_Silent_p.R77R	NM_006914.3	NP_008845.2	Q92753	RORB_HUMAN	RAR-related orphan receptor B						eye photoreceptor cell development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|large_intestine(4)|lung(1)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	12						AACACTGCCGACTGCAGAAGT	0.448000													4	23					0	0	1	0	0
PRRG2	5639	broad.mit.edu	37	19	50086495	50086495	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr19:50086495C>G	ENST00000246794.5	+	2	188	c.19C>G	c.(19-21)Ctg>Gtg	p.L7V	PRRG2_ENST00000596700.1_Intron	NM_000951.2	NP_000942.1	O14669	TMG2_HUMAN	proline rich Gla (G-carboxyglutamic acid) 2	7						extracellular region|integral to plasma membrane	calcium ion binding			lung(1)|skin(1)|soft_tissue(1)	3		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00295)|GBM - Glioblastoma multiforme(134;0.0121)		CCACCCCTCTCTGCTGCTGCT	0.522000													8	39					0	0	1	0	0
GSTK1	373156	broad.mit.edu	37	7	142962365	142962365	+	Silent	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr7:142962365C>T	ENST00000479303.1	+	4	622	c.564C>T	c.(562-564)atC>atT	p.I188I	GSTK1_ENST00000443571.2_Silent_p.I89I|GSTK1_ENST00000409500.3_Intron|AC073342.12_ENST00000427392.1_RNA|GSTK1_ENST00000358406.5_Silent_p.I132I	NM_001143679.1	NP_001137151.1	Q9Y2Q3	GSTK1_HUMAN	glutathione S-transferase kappa 1	138						outer membrane-bounded periplasmic space|peroxisome	glutathione transferase activity|identical protein binding|protein disulfide oxidoreductase activity			lung(4)	4	Melanoma(164;0.059)				Glutathione(DB00143)	ATGAAGACATCACCGAGCCGC	0.587000													6	8					0	0	1	0	0
RIMBP2	23504	broad.mit.edu	37	12	130927066	130927066	+	Silent	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr12:130927066C>T	ENST00000261655.4	-	8	943	c.780G>A	c.(778-780)gaG>gaA	p.E260E	RIMBP2_ENST00000536002.1_Silent_p.E168E|RIMBP2_ENST00000535703.1_Silent_p.E168E	NM_015347.4	NP_056162.4	O15034	RIMB2_HUMAN	RIMS binding protein 2	260						cell junction|synapse				NS(2)|breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(33)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	96	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		TGTGCTCTCCCTCCAGGCCGA	0.592000													5	57					0	0	1	0	0
RYK	6259	broad.mit.edu	37	3	133896863	133896863	+	Silent	SNP	C	C	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr3:133896863C>A	ENST00000427044.2	-	12	1270	c.660G>T	c.(658-660)gtG>gtT	p.V220V	RYK_ENST00000296084.4_Silent_p.V410V			P34925	RYK_HUMAN	receptor-like tyrosine kinase	406					corpus callosum development|positive regulation of MAPKKK cascade|Wnt receptor signaling pathway	cytoplasm|integral to plasma membrane|nucleus	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(1)|ovary(3)	4						AAGGCAATATCACCATGGGCT	0.338000													7	23					5.18039e-06	5.56496e-06	1	1	0
BIN1	274	broad.mit.edu	37	2	127806111	127806111	+	Missense_Mutation	SNP	C	C	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr2:127806111C>A	ENST00000316724.5	-	19	2184	c.1773G>T	c.(1771-1773)agG>agT	p.R591S	BIN1_ENST00000348750.4_Missense_Mutation_p.R407S|BIN1_ENST00000393041.3_Missense_Mutation_p.R473S|BIN1_ENST00000357970.3_Missense_Mutation_p.R548S|BIN1_ENST00000259238.4_Missense_Mutation_p.R495S|BIN1_ENST00000352848.3_Missense_Mutation_p.R452S|BIN1_ENST00000351659.3_Missense_Mutation_p.R504S|BIN1_ENST00000393040.3_Missense_Mutation_p.R480S|BIN1_ENST00000346226.3_Missense_Mutation_p.R516S|BIN1_ENST00000376113.2_Missense_Mutation_p.R422S|BIN1_ENST00000409400.1_Missense_Mutation_p.R437S	NM_139343.2	NP_647593.1	O00499	BIN1_HUMAN	bridging integrator 1	591	SH3.				cell proliferation|endocytosis|interspecies interaction between organisms|multicellular organismal development	actin cytoskeleton|nucleus				NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(3)|lung(6)|ovary(3)|prostate(3)|skin(3)	24	Colorectal(110;0.0831)			BRCA - Breast invasive adenocarcinoma(221;0.073)		GTCATGGGACCCTCTCAGTGA	0.552000													12	34					0.00136819	0.00142015	1	1	0
NAGS	162417	broad.mit.edu	37	17	42082124	42082124	+	Silent	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr17:42082124G>C	ENST00000293404.3	+	1	211	c.93G>C	c.(91-93)ctG>ctC	p.L31L		NM_153006.2	NP_694551.1	Q8N159	NAGS_HUMAN	N-acetylglutamate synthase	31					arginine biosynthetic process|urea cycle	mitochondrial matrix	acetyl-CoA:L-glutamate N-acetyltransferase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	8		Breast(137;0.00536)|Prostate(33;0.0724)		BRCA - Breast invasive adenocarcinoma(366;0.113)	L-Glutamic Acid(DB00142)	CCCGAAGGCTGAGCTGTggcg	0.766000													5	9					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80665430	80665430	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr12:80665430C>T	ENST00000458043.2	+	23	2500	c.2494C>T	c.(2494-2496)Cac>Tac	p.H832Y	OTOGL_ENST00000547103.1_Missense_Mutation_p.H832Y	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						ATCTGAAGTTCACATCTGCCC	0.393000													11	11					0	0	1	0	0
OR13A1	79290	broad.mit.edu	37	10	45799096	45799096	+	Missense_Mutation	SNP	A	A	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr10:45799096A>T	ENST00000553795.1	-	4	1083	c.775T>A	c.(775-777)Tgc>Agc	p.C259S	OR13A1_ENST00000536058.1_Missense_Mutation_p.C259S|OR13A1_ENST00000374401.2_Missense_Mutation_p.C259S	NM_001004297.2	NP_001004297.2	Q8NGR1	O13A1_HUMAN	olfactory receptor, family 13, subfamily A, member 1	259					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|skin(2)|urinary_tract(1)	19						TGGGAAGAGCAGGTGGAGAAG	0.557000													6	126					0	0	1	0	0
CRTC2	200186	broad.mit.edu	37	1	153930887	153930887	+	Silent	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr1:153930887C>T	ENST00000368633.1	-	1	214	c.87G>A	c.(85-87)caG>caA	p.Q29Q	CRTC2_ENST00000368630.3_Silent_p.Q29Q	NM_181715.2	NP_859066.1	Q53ET0	CRTC2_HUMAN	CREB regulated transcription coactivator 2	29					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			NS(1)|breast(1)|cervix(2)|endometrium(4)|large_intestine(5)|lung(8)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)	27	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GACGCTGCTTCTGCAGCGCAA	0.672000													8	25					0	0	1	0	0
GCC2	9648	broad.mit.edu	37	2	109086371	109086371	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr2:109086371G>A	ENST00000309863.6	+	6	1300	c.586G>A	c.(586-588)Gag>Aag	p.E196K	GCC2_ENST00000485546.1_3'UTR	NM_181453.3	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain containing 2	196					Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			breast(8)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	54						AGGCTTTGAGGAGCAAATTTT	0.338000													7	74					0	0	1	0	0
CLEC14A	161198	broad.mit.edu	37	14	38724135	38724135	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr14:38724135C>T	ENST00000342213.2	-	1	1439	c.1093G>A	c.(1093-1095)Gag>Aag	p.E365K		NM_175060.2	NP_778230.1	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	365						integral to membrane	sugar binding			breast(1)|cervix(2)|endometrium(2)|large_intestine(7)|lung(9)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		GCCTTTGACTCGGCTTGAAGG	0.493000													11	22					0	0	1	0	0
MYLK2	85366	broad.mit.edu	37	20	30408033	30408033	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr20:30408033G>C	ENST00000375994.2	+	2	430	c.157G>C	c.(157-159)Gat>Cat	p.D53H	MYLK2_ENST00000375985.4_Missense_Mutation_p.D53H			Q9H1R3	MYLK2_HUMAN	myosin light chain kinase 2	53					cardiac muscle tissue morphogenesis|regulation of muscle filament sliding		ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	33			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			CCTGAAGAAAGATGCCAAAGC	0.627000													46	46					0	0	1	0	0
CD3EAP	10849	broad.mit.edu	37	19	45911714	45911714	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr19:45911714C>T	ENST00000309424.3	+	3	976	c.488C>T	c.(487-489)tCa>tTa	p.S163L	ERCC1_ENST00000300853.3_3'UTR|ERCC1_ENST00000423698.2_3'UTR|CD3EAP_ENST00000589804.1_Missense_Mutation_p.S165L	NM_012099.1	NP_036231.1	O15446	RPA34_HUMAN	CD3e molecule, epsilon associated protein	163					rRNA transcription|transmembrane receptor protein tyrosine kinase signaling pathway	chromosome|RNA polymerase I transcription factor complex	DNA-directed RNA polymerase activity			breast(2)|endometrium(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)	11		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0251)		GGGCCTAGGTCAGCCTTGGCC	0.632000													57	18					0	0	1	0	0
CCDC178	374864	broad.mit.edu	37	18	30804866	30804866	+	Missense_Mutation	SNP	A	A	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr18:30804866A>G	ENST00000383096.3	-	17	1873	c.1691T>C	c.(1690-1692)cTt>cCt	p.L564P	CCDC178_ENST00000403303.1_Missense_Mutation_p.L564P|CCDC178_ENST00000402325.1_Missense_Mutation_p.L564P|CCDC178_ENST00000406524.2_Missense_Mutation_p.L564P|CCDC178_ENST00000300227.8_Missense_Mutation_p.L564P|CCDC178_ENST00000583930.1_Missense_Mutation_p.L564P|CCDC178_ENST00000579916.1_Intron|CCDC178_ENST00000579947.1_Missense_Mutation_p.L564P					coiled-coil domain containing 178																		TTTCCGCTCAAGTGCCTGGAC	0.353000													3	12					0	0	1	0	0
CYYR1	116159	broad.mit.edu	37	21	27852609	27852609	+	Missense_Mutation	SNP	T	T	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr21:27852609T>C	ENST00000299340.4	-	3	659	c.316A>G	c.(316-318)Acc>Gcc	p.T106A	CYYR1_ENST00000435845.2_3'UTR|CYYR1_ENST00000400043.3_Missense_Mutation_p.T106A|AP001597.1_ENST00000357401.3_RNA|AP001597.1_ENST00000414486.1_RNA	NM_052954.2	NP_443186.1	Q96J86	CYYR1_HUMAN	cysteine/tyrosine-rich 1	106						integral to membrane				large_intestine(2)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	15						GAGGAGACGGTGTTGATGTGA	0.507000													11	163					0	0	1	0	0
ARIH2OS	646450	broad.mit.edu	37	3	48956225	48956225	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr3:48956225C>T	ENST00000408959.2	-	1	593	c.358G>A	c.(358-360)Gtc>Atc	p.V120I		NM_001123040.1	NP_001116512.1			ariadne homolog 2 opposite strand																		ACCCGAGCGACCGTGGGTCGA	0.667000													8	16					0	0	1	0	0
HADHB	3032	broad.mit.edu	37	2	26507037	26507037	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr2:26507037G>A	ENST00000317799.5	+	13	1218	c.1114G>A	c.(1114-1116)Gat>Aat	p.D372N	HADHB_ENST00000494615.1_3'UTR|HADHB_ENST00000405867.3_Missense_Mutation_p.D249N|HADHB_ENST00000545822.1_Missense_Mutation_p.D350N|HADHB_ENST00000537713.1_Missense_Mutation_p.D357N	NM_000183.2	NP_000174.1	P55084	ECHB_HUMAN	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit	372					fatty acid beta-oxidation	mitochondrial nucleoid	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acyltransferase activity|enoyl-CoA hydratase activity|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|skin(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GACCATGAATGATATTGATGC	0.299000													20	39					0	0	1	0	0
RRBP1	6238	broad.mit.edu	37	20	17602402	17602402	+	Missense_Mutation	SNP	A	A	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr20:17602402A>G	ENST00000377813.1	-	15	3560	c.3257T>C	c.(3256-3258)cTg>cCg	p.L1086P	RRBP1_ENST00000246043.4_Missense_Mutation_p.L1086P|RRBP1_ENST00000360807.4_Missense_Mutation_p.L653P|RRBP1_ENST00000455029.2_Missense_Mutation_p.L427P|RRBP1_ENST00000377807.2_Missense_Mutation_p.L653P|RRBP1_ENST00000470422.1_5'UTR			Q9P2E9	RRBP1_HUMAN	ribosome binding protein 1	1086					protein transport|translation|transmembrane transport	integral to endoplasmic reticulum membrane|ribosome	receptor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|prostate(6)	28						GAGATCCTGCAGCCACTCGGT	0.607000													12	19					0	0	1	0	0
FLII	2314	broad.mit.edu	37	17	18156960	18156960	+	Silent	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr17:18156960G>C	ENST00000327031.4	-	8	978	c.753C>G	c.(751-753)ctC>ctG	p.L251L	FLII_ENST00000379450.4_Silent_p.L166L|FLII_ENST00000579294.1_Silent_p.L240L|FLII_ENST00000584444.1_Intron|FLII_ENST00000545457.2_Silent_p.L197L|FLII_ENST00000578558.1_Silent_p.L251L	NM_002018.3	NP_002009.1	Q13045	FLII_HUMAN	flightless I homolog (Drosophila)	251	Interaction with LRRFIP1 and LRRFIP2.				multicellular organismal development|muscle contraction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	actin binding			central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32	all_neural(463;0.228)					TGCTGAGGTTGAGGCGGCGCA	0.612000													22	9					0	0	1	0	0
CTNNB1	1499	broad.mit.edu	37	3	41268817	41268817	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr3:41268817G>A	ENST00000349496.5	+	7	1335	c.1055G>A	c.(1054-1056)aGt>aAt	p.S352N	CTNNB1_ENST00000405570.1_Missense_Mutation_p.S352N|CTNNB1_ENST00000396185.3_Missense_Mutation_p.S352N|CTNNB1_ENST00000396183.3_Missense_Mutation_p.S352N|CTNNB1_ENST00000453024.1_Missense_Mutation_p.S345N	NM_001904.3	NP_001895.1	P35222	CTNB1_HUMAN	catenin (cadherin-associated protein), beta 1, 88kDa	352					adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding		CTNNB1/PLAG1(60)	NS(4)|adrenal_gland(103)|biliary_tract(43)|bone(21)|breast(7)|central_nervous_system(260)|cervix(9)|endometrium(293)|eye(1)|haematopoietic_and_lymphoid_tissue(60)|kidney(202)|large_intestine(269)|liver(1010)|lung(63)|oesophagus(6)|ovary(106)|pancreas(126)|parathyroid(11)|pituitary(111)|pleura(2)|prostate(31)|salivary_gland(13)|skin(103)|small_intestine(17)|soft_tissue(792)|stomach(165)|thyroid(55)|upper_aerodigestive_tract(2)|urinary_tract(8)	3893				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)	GTCTGCTCTAGTAATAAGCCG	0.388000		15	"""H, Mis, T"""	PLAG1	"""colorectal, cvarian,  hepatoblastoma, others, pleomorphic salivary adenoma"""				Pilomatrixoma, Familial Clustering of				7	42					0	0	1	0	0
TOMM70A	9868	broad.mit.edu	37	3	100119577	100119577	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr3:100119577C>T	ENST00000284320.5	-	1	665	c.217G>A	c.(217-219)Gac>Aac	p.D73N		NM_014820.4	NP_055635.3	O94826	TOM70_HUMAN	translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)	73					protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane translocase complex	protein binding|protein transmembrane transporter activity			endometrium(11)|large_intestine(5)|lung(10)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	32						CCGCTGGCGTCGCCCCGGCCT	0.731000													3	5					0	0	1	0	0
ASNA1	439	broad.mit.edu	37	19	12849348	12849348	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr19:12849348C>G	ENST00000591090.1	+	3	287	c.185C>G	c.(184-186)tCc>tGc	p.S62C	ASNA1_ENST00000357332.3_Missense_Mutation_p.S62C			O43681	ASNA_HUMAN	arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)	62					response to arsenic-containing substance	endoplasmic reticulum|nucleolus|soluble fraction	arsenite-transporting ATPase activity|ATP binding|metal ion binding			endometrium(1)|lung(6)|ovary(3)	10					Adenosine triphosphate(DB00171)	GTCCAGCTCTCCAAGGGGCGT	0.527000													21	33					0	0	1	0	0
ZNF667	63934	broad.mit.edu	37	19	56954107	56954107	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr19:56954107G>A	ENST00000504904.3	-	7	976	c.257C>T	c.(256-258)tCg>tTg	p.S86L	ZNF667_ENST00000591790.1_3'UTR|ZNF667_ENST00000342634.3_Missense_Mutation_p.S214L|ZNF667_ENST00000292069.6_Missense_Mutation_p.S86L			Q5HYK9	ZN667_HUMAN	zinc finger protein 667	86					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	38		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		TTTAGACCCCGAGTCTGAAAG	0.343000													4	33					0	0	1	0	0
RNF13	11342	broad.mit.edu	37	3	149619891	149619891	+	Missense_Mutation	SNP	G	G	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr3:149619891G>T	ENST00000344229.3	+	7	1144	c.442G>T	c.(442-444)Gtc>Ttc	p.V148F	RNF13_ENST00000361785.6_Missense_Mutation_p.V29F|RNF13_ENST00000392894.3_Missense_Mutation_p.V148F	NM_007282.4	NP_009213.1	O43567	RNF13_HUMAN	ring finger protein 13	148	PA.				protein autoubiquitination	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane|nuclear inner membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|skin(2)	11		all_neural(597;0.0138)|Myeloproliferative disorder(1037;0.0255)	LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			CATTCCATCTGTCTTTATTGG	0.269000													22	17					5.35047e-06	5.73515e-06	1	1	0
ANKEF1	63926	broad.mit.edu	37	20	10036257	10036257	+	Silent	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr20:10036257G>A	ENST00000378380.3	+	10	2609	c.2280G>A	c.(2278-2280)caG>caA	p.Q760Q	SNAP25-AS1_ENST00000603542.1_RNA|SNAP25-AS1_ENST00000421143.2_RNA|ANKEF1_ENST00000488991.1_3'UTR|ANKEF1_ENST00000378392.1_Silent_p.Q760Q	NM_198798.1	NP_942093.1			ankyrin repeat and EF-hand domain containing 1																		TGCCTTTTCAGAAGAACATCA	0.483000													12	36					0	0	1	0	0
NUP205	23165	broad.mit.edu	37	7	135311064	135311064	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr7:135311064C>G	ENST00000285968.6	+	33	4774	c.4748C>G	c.(4747-4749)gCt>gGt	p.A1583G		NM_015135.2	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	1583					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(4)|central_nervous_system(2)|endometrium(9)|kidney(7)|large_intestine(17)|liver(4)|lung(36)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	93						GTGAGACTAGCTCAATGCCAA	0.443000													12	38					0	0	1	0	0
CPED1	79974	broad.mit.edu	37	7	120884286	120884286	+	Missense_Mutation	SNP	C	C	T	rs148996529	byFrequency	TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr7:120884286C>T	ENST00000310396.5	+	18	2671	c.2204C>T	c.(2203-2205)tCg>tTg	p.S735L	CPED1_ENST00000450913.2_Missense_Mutation_p.S735L|CPED1_ENST00000423795.1_Missense_Mutation_p.S515L	NM_024913.4	NP_079189.4			cadherin-like and PC-esterase domain containing 1									p.S735L(1)									CTTAGTTGTTCGGACAACAGG	0.468000													39	32					0	0	1	0	0
DYRK1A	1859	broad.mit.edu	37	21	38884571	38884571	+	Missense_Mutation	SNP	A	A	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr21:38884571A>T	ENST00000339659.4	+	11	3472	c.2002A>T	c.(2002-2004)Aat>Tat	p.N668Y	DYRK1A_ENST00000455387.2_Missense_Mutation_p.N449Y|DYRK1A_ENST00000338785.3_3'UTR|DYRK1A_ENST00000398960.2_Missense_Mutation_p.N677Y	NM_130436.2	NP_569120.1	Q13627	DYR1A_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A		Poly-Ser.|Ser/Thr-rich.				nervous system development|peptidyl-tyrosine phosphorylation|protein autophosphorylation	nuclear speck	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding|protein self-association|protein serine/threonine kinase activity			breast(4)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(10)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	42						TAACCAAGGCAATCAGGCCTA	0.507000													6	119					0	0	1	0	0
EI24	9538	broad.mit.edu	37	11	125448125	125448125	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr11:125448125G>A	ENST00000278903.6	+	6	655	c.413G>A	c.(412-414)aGc>aAc	p.S138N	EI24_ENST00000343678.4_Missense_Mutation_p.S138N|STT3A-AS1_ENST00000532714.1_RNA|EI24_ENST00000530985.1_3'UTR|STT3A-AS1_ENST00000530526.1_RNA	NM_004879.3	NP_004870.3	O14681	EI24_HUMAN	etoposide induced 2.4	138					apoptosis|autophagy|induction of apoptosis|negative regulation of cell growth	endoplasmic reticulum membrane|integral to membrane|nuclear membrane				large_intestine(1)|lung(9)|ovary(1)	11	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.64e-07)|OV - Ovarian serous cystadenocarcinoma(99;0.0975)		TTTGTGCTTAGCAAAGTGGTG	0.502000													46	28					0	0	1	0	0
TRAPPC9	83696	broad.mit.edu	37	8	141461150	141461150	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr8:141461150G>C	ENST00000389328.4	-	2	631	c.617C>G	c.(616-618)tCc>tGc	p.S206C	TRAPPC9_ENST00000389327.3_Missense_Mutation_p.S108C|TRAPPC9_ENST00000438773.2_Missense_Mutation_p.S108C	NM_031466.5	NP_113654.4	Q96Q05	TPPC9_HUMAN	trafficking protein particle complex 9	108					cell differentiation	endoplasmic reticulum|Golgi apparatus				breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(16)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	47						ATACAGTGTGGAGCCGTAGAT	0.592000													21	57					0	0	1	0	0
MAN2C1	4123	broad.mit.edu	37	15	75650805	75650805	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr15:75650805C>T	ENST00000565683.1	-	20	2463	c.2452G>A	c.(2452-2454)Gag>Aag	p.E818K	MAN2C1_ENST00000563622.1_Missense_Mutation_p.E702K|MAN2C1_ENST00000569482.1_Missense_Mutation_p.E801K|MAN2C1_ENST00000267978.5_Missense_Mutation_p.E801K	NM_001256494.1	NP_001243423.1	Q9NTJ4	MA2C1_HUMAN	mannosidase, alpha, class 2C, member 1	801			R -> H (in dbSNP:rs58557444).		mannose metabolic process		alpha-mannosidase activity|carbohydrate binding|protein binding|zinc ion binding			central_nervous_system(4)|endometrium(4)|kidney(6)|large_intestine(6)|lung(20)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	44						CCGACTACCTCGGTGTGGAAG	0.627000													3	35					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	107022191	107022191	+	Silent	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr10:107022191C>T	ENST00000369701.3	+	26	3773	c.3546C>T	c.(3544-3546)ctC>ctT	p.L1182L		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	1182						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		AAATCACACTCAGTGACTTTA	0.512000													9	20					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47479629	47479629	+	Splice_Site	SNP	C	C	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr18:47479629C>A	ENST00000285039.7	-	14	2052		c.e14+1			NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB						protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		ACACTCTTTACCTTGCTGGCC	0.537000													3	12					0.00909568	0.00930369	1	1	0
TCTN2	79867	broad.mit.edu	37	12	124171451	124171451	+	Silent	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr12:124171451C>G	ENST00000303372.5	+	6	761	c.633C>G	c.(631-633)gtC>gtG	p.V211V	TCTN2_ENST00000426174.2_Silent_p.V210V	NM_001143850.2|NM_024809.4	NP_001137322.1|NP_079085.2	Q96GX1	TECT2_HUMAN	tectonic family member 2	211					cilium assembly|smoothened signaling pathway	integral to membrane				breast(2)|cervix(2)|endometrium(4)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000163)|Epithelial(86;0.000502)|all cancers(50;0.00451)		GAGGAGACGTCAATCCTCCTT	0.527000													10	103					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56369552	56369552	+	Silent	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr19:56369552C>T	ENST00000301295.6	+	3	1215	c.793C>T	c.(793-795)Ctg>Ttg	p.L265L	NLRP4_ENST00000346986.5_Silent_p.L265L|NLRP4_ENST00000587891.1_Silent_p.L190L	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	265	NACHT.						ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		GAGCAGTTTGCTGAGGAAGAA	0.572000													12	97					0	0	1	0	0
COG1	9382	broad.mit.edu	37	17	71202315	71202315	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr17:71202315C>G	ENST00000299886.4	+	11	2613	c.2533C>G	c.(2533-2535)Ctg>Gtg	p.L845V		NM_018714.2	NP_061184.1	Q8WTW3	COG1_HUMAN	component of oligomeric golgi complex 1	845					Golgi organization|intra-Golgi vesicle-mediated transport|protein transport	Golgi membrane|Golgi transport complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18			LUSC - Lung squamous cell carcinoma(166;0.197)			GACTGACCACCTGGAAGCCCT	0.428000													16	46					0	0	1	0	0
CLIP1	6249	broad.mit.edu	37	12	122825998	122825998	+	Missense_Mutation	SNP	G	G	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr12:122825998G>T	ENST00000358808.2	-	10	1874	c.1720C>A	c.(1720-1722)Cag>Aag	p.Q574K	CLIP1_ENST00000545889.1_Missense_Mutation_p.Q275K|CLIP1_ENST00000537178.1_Missense_Mutation_p.Q539K|CLIP1_ENST00000540338.1_Missense_Mutation_p.Q585K|CLIP1_ENST00000302528.7_Missense_Mutation_p.Q574K|CLIP1_ENST00000361654.4_Missense_Mutation_p.Q539K	NM_001247997.1|NM_002956.2	NP_001234926.1|NP_002947.1	P30622	CLIP1_HUMAN	CAP-GLY domain containing linker protein 1	585					mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			NS(1)|breast(5)|endometrium(4)|kidney(5)|large_intestine(16)|liver(1)|lung(21)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		ATCTCCTTCTGATGAGTTTCT	0.448000													24	114					1.10923e-09	1.24884e-09	1	1	0
PREP	5550	broad.mit.edu	37	6	105726282	105726282	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr6:105726282C>T	ENST00000369110.3	-	15	2062	c.1870G>A	c.(1870-1872)Gaa>Aaa	p.E624K		NM_002726.4	NP_002717.3	P48147	PPCE_HUMAN	prolyl endopeptidase	624					proteolysis		serine-type endopeptidase activity			breast(1)|endometrium(2)|large_intestine(7)|lung(12)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	29		all_cancers(87;0.000128)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0344)|Lung NSC(302;0.191)|Colorectal(196;0.202)			Oxytocin(DB00107)	tcatctgcttctggtaacttc	0.507000													17	10					0	0	1	0	0
SLC45A4	57210	broad.mit.edu	37	8	142228883	142228883	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr8:142228883C>T	ENST00000519067.1	-	4	1006	c.703G>A	c.(703-705)Gag>Aag	p.E235K	SLC45A4_ENST00000433583.2_Missense_Mutation_p.E228K|SLC45A4_ENST00000024061.3_Missense_Mutation_p.E235K|SLC45A4_ENST00000517878.1_Missense_Mutation_p.E286K			Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	286					transport	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			GACTGTACCTCGTCTGGGAAG	0.687000													28	132					0	0	1	0	0
PTPDC1	138639	broad.mit.edu	37	9	96846860	96846860	+	Silent	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr9:96846860C>T	ENST00000288976.3	+	1	115	c.48C>T	c.(46-48)ctC>ctT	p.L16L	PTPDC1_ENST00000375360.3_Intron	NM_001253829.1|NM_152422.4	NP_001240758.1|NP_689635.3	A2A3K4	PTPC1_HUMAN	protein tyrosine phosphatase domain containing 1	0							protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			endometrium(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	32						TGCGCTTCCTCAGCTCCTTTC	0.682000													35	11					0	0	1	0	0
SUGP2	10147	broad.mit.edu	37	19	19136462	19136462	+	Missense_Mutation	SNP	T	T	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr19:19136462T>G	ENST00000601879.1	-	3	992	c.695A>C	c.(694-696)cAg>cCg	p.Q232P	SUGP2_ENST00000452918.2_Missense_Mutation_p.Q232P|SUGP2_ENST00000600377.1_Missense_Mutation_p.Q246P|SUGP2_ENST00000598202.1_5'UTR|SUGP2_ENST00000456085.2_Intron|SUGP2_ENST00000337018.6_Missense_Mutation_p.Q232P			Q8IX01	SUGP2_HUMAN	SURP and G patch domain containing 2	232					mRNA processing|RNA splicing	nucleus	RNA binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						GAGCAGGCCCTGAGTCTCCCC	0.517000													19	31					0	0	1	0	0
CASC3	22794	broad.mit.edu	37	17	38296863	38296863	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr17:38296863C>T	ENST00000264645.7	+	1	288	c.62C>T	c.(61-63)tCg>tTg	p.S21L		NM_007359.4	NP_031385.2	O15234	CASC3_HUMAN	cancer susceptibility candidate 3	21					mRNA processing|mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translation|response to stress|RNA splicing	exon-exon junction complex|nuclear speck|perinuclear region of cytoplasm	identical protein binding|RNA binding|ubiquitin protein ligase binding			endometrium(4)|kidney(2)|large_intestine(3)|lung(4)|ovary(1)|urinary_tract(2)	16						TCTGGTGCTTCGGGCTCcgac	0.716000													16	18					0	0	1	0	0
IGHV4-39	28394	broad.mit.edu	37	14	106878026	106878026	+	RNA	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr14:106878026C>T	ENST00000390619.2	-	0	100																											GAGCCGCCACCAGCAGGAGGA	0.488000													9	11					0	0	1	0	0
FCGR2A	2212	broad.mit.edu	37	1	161479774	161479774	+	Missense_Mutation	SNP	G	G	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr1:161479774G>T	ENST00000271450.6	+	4	567	c.529G>T	c.(529-531)Gca>Tca	p.A177S	FCGR2A_ENST00000367972.4_Missense_Mutation_p.A176S	NM_001136219.1|NM_021642.3	NP_001129691.1|NP_067674.2	P12318	FCG2A_HUMAN	Fc fragment of IgG, low affinity IIa, receptor (CD32)	177	Ig-like C2-type 2.					integral to membrane|plasma membrane	IgG binding|receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(2)|large_intestine(2)|lung(11)|ovary(1)	19	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	CATCCCACAAGCAAACCACAG	0.502000													9	70					2.74318e-10	3.10978e-10	1	1	0
FBXL19	54620	broad.mit.edu	37	16	30939803	30939803	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr16:30939803G>C	ENST00000338343.4	+	6	1030	c.643G>C	c.(643-645)Gag>Cag	p.E215Q	FBXL19_ENST00000565690.1_Missense_Mutation_p.E142Q|FBXL19_ENST00000380310.2_Missense_Mutation_p.E235Q|FBXL19_ENST00000471231.2_5'UTR|FBXL19_ENST00000562319.1_Missense_Mutation_p.E215Q			Q6PCT2	FXL19_HUMAN	F-box and leucine-rich repeat protein 19	235	Pro-rich.						DNA binding|zinc ion binding			breast(2)|endometrium(3)|lung(5)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	16						AGGAGGCCGAGAGAGGCACCT	0.632000													10	8					0	0	1	0	0
FGFR1	2260	broad.mit.edu	37	8	38271223	38271223	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr8:38271223G>A	ENST00000447712.2	-	18	3333	c.2392C>T	c.(2392-2394)Cat>Tat	p.H798Y	FGFR1_ENST00000335922.5_Missense_Mutation_p.H788Y|FGFR1_ENST00000397113.2_Missense_Mutation_p.H796Y|FGFR1_ENST00000397103.1_Missense_Mutation_p.H709Y|FGFR1_ENST00000532791.1_Missense_Mutation_p.H796Y|FGFR1_ENST00000425967.3_Missense_Mutation_p.H829Y|FGFR1_ENST00000397108.4_Missense_Mutation_p.H796Y|FGFR1_ENST00000326324.6_Missense_Mutation_p.H707Y|FGFR1_ENST00000397091.5_Missense_Mutation_p.H796Y|FGFR1_ENST00000356207.5_Missense_Mutation_p.H709Y|FGFR1_ENST00000341462.5_Missense_Mutation_p.H798Y	NM_001174063.1|NM_015850.3|NM_023110.2	NP_001167534.1|NP_056934.2|NP_075598.2	P11362	FGFR1_HUMAN	fibroblast growth factor receptor 1	798					axon guidance|cell growth|insulin receptor signaling pathway|MAPKKK cascade|positive regulation of cell proliferation|skeletal system development	extracellular region|integral to plasma membrane|membrane fraction	ATP binding|fibroblast growth factor receptor activity|heparin binding|protein homodimerization activity		FGFR1/ZNF703(2)	breast(2)|central_nervous_system(7)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(18)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(2)	50	all_cancers(2;9.05e-47)|all_epithelial(2;2.64e-50)|all_lung(3;1.71e-23)|Lung NSC(2;3.61e-23)|Colorectal(12;0.000442)	Breast(189;1.48e-05)|all_lung(54;0.00354)|Lung NSC(58;0.0138)|Hepatocellular(245;0.065)	Epithelial(3;3.96e-34)|all cancers(3;3.06e-30)|BRCA - Breast invasive adenocarcinoma(5;2.28e-21)|COAD - Colon adenocarcinoma(9;0.24)		Palifermin(DB00039)	AGCGGCTCATGAGAGAAGACG	0.662000		1	T	"""BCR, FOP, ZNF198, CEP1"""	"""MPD, NHL"""		"""Pfeiffer syndrome, Kallman syndrome"""						5	27					0	0	1	0	0
SDF4	51150	broad.mit.edu	37	1	1158733	1158733	+	Silent	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr1:1158733G>A	ENST00000263741.7	-	4	760	c.468C>T	c.(466-468)caC>caT	p.H156H	SDF4_ENST00000545427.1_Silent_p.H156H|SDF4_ENST00000360001.6_Silent_p.H156H	NM_016176.3|NM_016547.2	NP_057260.2|NP_057631.1	Q9BRK5	CAB45_HUMAN	stromal cell derived factor 4	156	EF-hand 2.				cerebellum development|fat cell differentiation|response to ethanol|UV protection|zymogen granule exocytosis	bleb|Golgi lumen|late endosome|soluble fraction	calcium ion binding|identical protein binding|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	11	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;7.85e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.42e-21)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;4.83e-05)|Kidney(185;0.00252)|BRCA - Breast invasive adenocarcinoma(365;0.00263)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0368)|Lung(427;0.204)		CCCAAGACACGTGACCTGGAA	0.537000													5	42					0	0	1	0	0
C1orf127	148345	broad.mit.edu	37	1	11007860	11007860	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr1:11007860C>G	ENST00000377004.4	-	12	2331	c.2332G>C	c.(2332-2334)Gaa>Caa	p.E778Q	C1orf127_ENST00000377008.4_Missense_Mutation_p.E611Q	NM_001170754.1	NP_001164225.1	B7ZLG7	B7ZLG7_HUMAN	chromosome 1 open reading frame 127	629										NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(5)	32	Ovarian(185;0.249)	Lung NSC(185;0.000226)|all_lung(284;0.000302)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.71e-07)|COAD - Colon adenocarcinoma(227;7.79e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000305)|Kidney(185;0.000785)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|READ - Rectum adenocarcinoma(331;0.0509)		AAGGGGTATTCAAGCTCCACC	0.642000													5	22					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144943015	144943015	+	Silent	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr8:144943015G>C	ENST00000525985.1	-	2	4478	c.4407C>G	c.(4405-4407)ctC>ctG	p.L1469L				P58107	EPIPL_HUMAN	epiplakin 1	1469						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GCAGGTCCCAGAGTGACACGC	0.647000													6	27					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100691270	100691270	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr7:100691270G>A	ENST00000306151.4	+	4	12473	c.12409G>A	c.(12409-12411)Gga>Aga	p.G4137R		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	4137	EGF-like.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CACAGGCTTTGGAGATGGGTG	0.517000													13	109					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89949431	89949431	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr5:89949431C>G	ENST00000405460.2	+	20	4136	c.4040C>G	c.(4039-4041)tCc>tGc	p.S1347C		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	1347				S -> F (in Ref. 2; AAL30811).	cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TACCATCCCTCCAGGAATAAT	0.448000													6	6					0	0	1	0	0
SPATA31A3	727830	broad.mit.edu	37	9	40702779	40702779	+	Missense_Mutation	SNP	G	G	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr9:40702779G>T	ENST00000356699.5	+	4	465	c.436G>T	c.(436-438)Gct>Tct	p.A146S	SPATA31A3_ENST00000463536.1_3'UTR	NM_001083124.1	NP_001076593.1			SPATA31 subfamily A, member 3																		GGAAGATGCTGCTCCCATTCT	0.592000													19	337					3.51602e-12	4.05124e-12	1	1	0
AKR1E2	83592	broad.mit.edu	37	10	4889710	4889710	+	Missense_Mutation	SNP	C	C	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr10:4889710C>A	ENST00000298375.7	+	10	1022	c.951C>A	c.(949-951)caC>caA	p.H317Q	AKR1E2_ENST00000334019.4_Missense_Mutation_p.H260Q|AKR1E2_ENST00000345253.5_Missense_Mutation_p.H219Q	NM_001040177.2	NP_001035267.1	Q96JD6	AKCL2_HUMAN	aldo-keto reductase family 1, member E2	317						cytoplasm	1,5-anhydro-D-fructose reductase activity			NS(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(9)	15						ATCCTTTCCACATAGAATACT	0.378000													7	27					3.09899e-07	3.35837e-07	1	1	0
SFI1	9814	broad.mit.edu	37	22	31971290	31971290	+	Silent	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr22:31971290G>A	ENST00000432498.1	+	10	1389	c.996G>A	c.(994-996)cgG>cgA	p.R332R	SFI1_ENST00000414585.1_Silent_p.R179R|SFI1_ENST00000400289.1_Silent_p.R250R|SFI1_ENST00000443011.1_Silent_p.R179R|SFI1_ENST00000400288.2_Silent_p.R332R|SFI1_ENST00000443326.1_Silent_p.R250R|SFI1_ENST00000540643.1_Silent_p.R308R	NM_014775.3	NP_055590.2	A8K8P3	SFI1_HUMAN	Sfi1 homolog, spindle assembly associated (yeast)	332					G2/M transition of mitotic cell cycle	centriole|cytosol				NS(2)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(3)|upper_aerodigestive_tract(3)	38						CCTGGGAGCGGAGGGAGAGCT	0.537000													4	63					0	0	1	0	0
TRAV8-7	28679	broad.mit.edu	37	14	22600733	22600733	+	RNA	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr14:22600733C>T	ENST00000390456.3	+	0	78																											AGCTTGATGGCCACATCACTG	0.478000													12	22					0	0	1	0	0
CENPF	1063	broad.mit.edu	37	1	214816648	214816648	+	Missense_Mutation	SNP	T	T	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr1:214816648T>G	ENST00000366955.3	+	12	5135	c.4967T>G	c.(4966-4968)cTt>cGt	p.L1656R		NM_016343.3	NP_057427.3	P49454	CENPF_HUMAN	centromere protein F, 350/400kDa	1752					cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			NS(2)|breast(2)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(37)|lung(47)|ovary(7)|prostate(3)|skin(6)|stomach(1)|urinary_tract(1)	126				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		CGGTCTTTGCTTGGCATCGAC	0.433000													9	37					0	0	1	0	0
PRB4	5545	broad.mit.edu	37	12	11461478	11461478	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr12:11461478G>C	ENST00000279575.1	-	3	472	c.439C>G	c.(439-441)Caa>Gaa	p.Q147E	PRB4_ENST00000445719.2_Intron|PRB4_ENST00000535904.1_Missense_Mutation_p.Q147E	NM_001261399.1|NM_002723.4	NP_001248328.1|NP_002714.2	P10163	PRB4_HUMAN	proline-rich protein BstNI subfamily 4	210	9.5 X 21 AA tandem repeats of K-P-[EQ]- [GR]-[PR]-[PR]-P-Q-G-G-N-Q-[PS]-[QH]- [RG]-[PT]-P-P-[PH]-P-G.		Missing (in allele M and allele S).			extracellular region				breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|skin(4)|upper_aerodigestive_tract(3)	30						TTACCTCCTTGTGGGGGTGGT	0.612000										HNSCC(22;0.051)			24	412					0	0	1	0	0
SRSF8	10929	broad.mit.edu	37	11	94801255	94801255	+	RNA	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr11:94801255G>C	ENST00000529911.1	+	0	895					NM_032102.3	NP_115285.1	Q9BRL6	SRSF8_HUMAN	serine/arginine-rich splicing factor 8						mRNA processing|RNA splicing	nucleus	nucleotide binding|RNA binding										GATGCATCAGGAAGCAACGTG	0.488000													4	6					0	0	1	0	0
RNF17	56163	broad.mit.edu	37	13	25448388	25448388	+	Splice_Site	SNP	G	G	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr13:25448388G>T	ENST00000255324.5	+	33	4635		c.e33+1		RNF17_ENST00000339524.3_Splice_Site|RNF17_ENST00000381921.1_Splice_Site	NM_001184993.1|NM_031277.2	NP_001171922.1|NP_112567.2	Q9BXT8	RNF17_HUMAN	ring finger protein 17						multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(3)|skin(6)	36		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		CATTAAACAGGTTAAAAATAA	0.279000													3	12					0.115264	0.115734	1	1	0
GUCY1B3	2983	broad.mit.edu	37	4	156698781	156698781	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr4:156698781G>C	ENST00000264424.8	+	4	366	c.284G>C	c.(283-285)aGa>aCa	p.R95T	GUCY1B3_ENST00000507146.1_Missense_Mutation_p.R27T|GUCY1B3_ENST00000505764.1_Missense_Mutation_p.R75T|GUCY1B3_ENST00000502959.1_Missense_Mutation_p.R95T|GUCY1B3_ENST00000503520.1_Missense_Mutation_p.R95T|GUCY1B3_ENST00000505154.1_Missense_Mutation_p.R27T|GUCY1B3_ENST00000513437.1_Missense_Mutation_p.R27T	NM_000857.2	NP_000848.1	Q02153	GCYB1_HUMAN	guanylate cyclase 1, soluble, beta 3	95					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble|intracellular membrane-bounded organelle	GTP binding|guanylate cyclase activity|receptor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.148)		TCTAATGTCAGAGAATTTCTA	0.368000													33	23					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181767545	181767545	+	Missense_Mutation	SNP	A	A	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr1:181767545A>C	ENST00000526775.1	+	46	6496	c.6331A>C	c.(6331-6333)Agc>Cgc	p.S2111R	CACNA1E_ENST00000367567.4_Missense_Mutation_p.S1737R|CACNA1E_ENST00000357570.5_Missense_Mutation_p.S2124R|CACNA1E_ENST00000358338.5_Missense_Mutation_p.S2062R|CACNA1E_ENST00000367573.2_Missense_Mutation_p.S2173R|CACNA1E_ENST00000367570.1_Missense_Mutation_p.S2130R|CACNA1E_ENST00000360108.3_Missense_Mutation_p.S2154R	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	2173					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CCTTTCCTACAGCTCCCTGAT	0.627000													63	81					0	0	1	0	0
VNN2	8875	broad.mit.edu	37	6	133070833	133070833	+	Splice_Site	SNP	C	C	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr6:133070833C>A	ENST00000326499.6	-	6	1496		c.e6+1		VNN2_ENST00000525289.1_Splice_Site|VNN2_ENST00000525270.1_Splice_Site	NM_004665.2	NP_004656	O95498	VNN2_HUMAN	vanin 2						cellular component movement|pantothenate metabolic process	anchored to membrane|plasma membrane	pantetheine hydrolase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(155;0.00237)|GBM - Glioblastoma multiforme(226;0.0267)		AGTCCTCTTACCTCAAATTTT	0.363000													9	8					0.00448238	0.0046428	1	1	0
KCNQ4	9132	broad.mit.edu	37	1	41285618	41285618	+	Silent	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr1:41285618C>G	ENST00000347132.5	+	6	988	c.906C>G	c.(904-906)ggC>ggG	p.G302G	KCNQ4_ENST00000509682.2_Silent_p.G302G|KCNQ4_ENST00000506017.1_3'UTR	NM_004700.3|NM_172163.2	NP_004691.2|NP_751895.1	P56696	KCNQ4_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 4	302					sensory perception of sound	basal plasma membrane|voltage-gated potassium channel complex				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(13)|skin(1)	26	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.38e-17)			TGGCTGCTGGCTTCGCCTTAC	0.587000													15	83					0	0	1	0	0
OR9G1	390174	broad.mit.edu	37	11	56468635	56468635	+	Missense_Mutation	SNP	T	T	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr11:56468635T>C	ENST00000312153.1	+	1	772	c.772T>C	c.(772-774)Tac>Cac	p.Y258H		NM_001005213.1	NP_001005213.1			olfactory receptor, family 9, subfamily G, member 1											breast(2)|kidney(1)|lung(25)|stomach(2)|upper_aerodigestive_tract(1)	31						TCTCTACATCTACGCTCTCCC	0.448000													17	148					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28375377	28375377	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr15:28375377C>G	ENST00000261609.7	-	83	12842	c.12734G>C	c.(12733-12735)gGg>gCg	p.G4245A		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	4245					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CCCCTGCAACCCTTGGACCTG	0.567000													33	129					0	0	1	0	0
ZNF689	115509	broad.mit.edu	37	16	30615726	30615726	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr16:30615726C>G	ENST00000287461.3	-	3	1699	c.1362G>C	c.(1360-1362)gaG>gaC	p.E454D	RP11-146F11.5_ENST00000563540.1_RNA	NM_138447.1	NP_612456.1	Q96CS4	ZN689_HUMAN	zinc finger protein 689	454					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|prostate(1)|urinary_tract(1)	14			Colorectal(24;0.198)			GGAAAGGCTTCTCCCCCGTGT	0.642000													11	22					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56470287	56470287	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr6:56470287C>T	ENST00000370754.5	-	39	9039	c.9040G>A	c.(9040-9042)Gaa>Aaa	p.E3014K	DST_ENST00000361203.3_Missense_Mutation_p.E2836K|DST_ENST00000370788.2_Intron|DST_ENST00000312431.6_Missense_Mutation_p.E2836K|DST_ENST00000244364.6_Intron|DST_ENST00000421834.2_Intron|DST_ENST00000370769.4_Missense_Mutation_p.E2836K|DST_ENST00000446842.2_Missense_Mutation_p.E2510K			Q03001	DYST_HUMAN	dystonin	2836					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			ATTGATGTTTCATCTTCTATT	0.368000													17	44					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78582407	78582407	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr12:78582407G>C	ENST00000397909.2	+	33	6078	c.5905G>C	c.(5905-5907)Gat>Cat	p.D1969H	NAV3_ENST00000552300.1_Intron|NAV3_ENST00000266692.7_Missense_Mutation_p.D1770H|NAV3_ENST00000228327.6_Missense_Mutation_p.D1947H|NAV3_ENST00000536525.2_Missense_Mutation_p.D1947H			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1969						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						ATTCCGAATTGATACATCCAC	0.383000										HNSCC(70;0.22)			16	21					0	0	1	0	0
RLF	6018	broad.mit.edu	37	1	40705616	40705616	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr1:40705616G>C	ENST00000372771.4	+	8	5269	c.5242G>C	c.(5242-5244)Gag>Cag	p.E1748Q		NM_012421.3	NP_036553.2	Q13129	RLF_HUMAN	rearranged L-myc fusion	1748					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(18)|lung(18)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(4)|urinary_tract(2)	68	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			TGTCCCAAAAGAGAATTTTAG	0.378000													20	22					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179579168	179579168	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr2:179579168C>T	ENST00000589042.1	-	91	26557	c.26333G>A	c.(26332-26334)aGa>aAa	p.R8778K	TTN_ENST00000591111.1_Missense_Mutation_p.R8461K|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.R7534K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	8461	Ig-like 70.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTCACTTTCTCTAACGATTTC	0.403000													15	15					0	0	1	0	0
HP1BP3	50809	broad.mit.edu	37	1	21103106	21103106	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr1:21103106C>G	ENST00000312239.5	-	4	473	c.334G>C	c.(334-336)Gag>Cag	p.E112Q	HP1BP3_ENST00000375000.1_Missense_Mutation_p.E112Q|HP1BP3_ENST00000487117.1_5'UTR	NM_016287.3	NP_057371.2	Q5SSJ5	HP1B3_HUMAN	heterochromatin protein 1, binding protein 3	112					nucleosome assembly	nucleosome|nucleus	DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(5)|prostate(2)|skin(2)|urinary_tract(1)	16		all_lung(284;6.55e-06)|Lung NSC(340;6.59e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(152;1.26e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00015)|GBM - Glioblastoma multiforme(114;0.000521)|Kidney(64;0.000529)|STAD - Stomach adenocarcinoma(196;0.00311)|KIRC - Kidney renal clear cell carcinoma(64;0.00687)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.201)		TTGGTTTCCTCAGAAGACTTA	0.368000													20	35					0	0	1	0	0
LPCAT3	10162	broad.mit.edu	37	12	7086832	7086832	+	Silent	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr12:7086832G>A	ENST00000261407.4	-	10	1201	c.1116C>T	c.(1114-1116)ctC>ctT	p.L372L	LPCAT3_ENST00000535021.1_Intron	NM_005768.5	NP_005759.4	Q6P1A2	MBOA5_HUMAN	lysophosphatidylcholine acyltransferase 3	372					phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(4)|ovary(1)|skin(2)	17						GGCCGTGCCAGAGGGCCAGGA	0.532000													57	80					0	0	1	0	0
RGS9	8787	broad.mit.edu	37	17	63133669	63133669	+	Missense_Mutation	SNP	G	G	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr17:63133669G>T	ENST00000449996.3	+	1	83	c.11G>T	c.(10-12)cGa>cTa	p.R4L	RGS9_ENST00000262406.9_Missense_Mutation_p.R4L|RGS9_ENST00000443584.3_Missense_Mutation_p.R4L	NM_001081955.2	NP_001075424.1	O75916	RGS9_HUMAN	regulator of G-protein signaling 9	4					intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(8)|liver(2)|lung(12)|ovary(2)|prostate(3)|skin(3)	41						ATGACAATCCGACACCAAGGC	0.627000													5	50					0.014758	0.0150019	1	1	0
ARIH2OS	646450	broad.mit.edu	37	3	48956243	48956243	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr3:48956243C>T	ENST00000408959.2	-	1	575	c.340G>A	c.(340-342)Gat>Aat	p.D114N		NM_001123040.1	NP_001116512.1			ariadne homolog 2 opposite strand																		CGACCCCGATCCGGAAGTGAC	0.682000													9	15					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183600882	183600882	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr4:183600882G>C	ENST00000511685.1	+	8	1513	c.1390G>C	c.(1390-1392)Gag>Cag	p.E464Q	TENM3_ENST00000406950.2_Missense_Mutation_p.E464Q					teneurin transmembrane protein 3																		GAGCCTGCTTGAGACGGAGAG	0.542000													8	39					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100345823	100345823	+	RNA	SNP	A	A	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr7:100345823A>G	ENST00000542585.1	+	0	1235				ZAN_ENST00000421100.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000443370.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TGCAACCAGCATTGCTCCTTG	0.597000													3	28					0	0	1	0	0
MED14	9282	broad.mit.edu	37	X	40534543	40534543	+	Missense_Mutation	SNP	G	G	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chrX:40534543G>T	ENST00000324817.1	-	22	3069	c.2951C>A	c.(2950-2952)cCc>cAc	p.P984H	MED14_ENST00000496531.2_5'UTR	NM_004229.3	NP_004220.2	O60244	MED14_HUMAN	mediator complex subunit 14	984					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			NS(2)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(7)|lung(8)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						AGGAGAAGGGGGATTATCGTC	0.418000													8	9					1.76689e-08	1.96677e-08	1	1	0
SP6	80320	broad.mit.edu	37	17	45925060	45925060	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr17:45925060C>T	ENST00000536300.1	-	2	1067	c.736G>A	c.(736-738)Gat>Aat	p.D246N	SP6_ENST00000342234.2_Missense_Mutation_p.D246N	NM_001258248.1	NP_001245177.1	Q3SY56	SP6_HUMAN	Sp6 transcription factor	246					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|lung(5)|prostate(1)|skin(1)	8						TTGCCCCCATCGGGCCCACAT	0.672000													10	23					0	0	1	0	0
TTC16	158248	broad.mit.edu	37	9	130493182	130493182	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr9:130493182C>T	ENST00000373289.3	+	14	2200	c.2120C>T	c.(2119-2121)tCc>tTc	p.S707F	TTC16_ENST00000489226.1_3'UTR	NM_144965.1	NP_659402.1	Q8NEE8	TTC16_HUMAN	tetratricopeptide repeat domain 16	707							binding			central_nervous_system(2)|endometrium(3)|lung(7)|ovary(3)|pancreas(2)|prostate(4)|skin(1)	22						AAGAGGAACTCCAGCAAGACC	0.627000													40	21					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62295310	62295310	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr11:62295310C>G	ENST00000378024.4	-	5	6853	c.6579G>C	c.(6577-6579)ttG>ttC	p.L2193F	AHNAK_ENST00000530124.1_Intron|AHNAK_ENST00000257247.7_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	2193					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				TGGGGCCTTTCAAGTTTAAGT	0.473000													39	153					0	0	1	0	0
TREM2	54209	broad.mit.edu	37	6	41126514	41126514	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr6:41126514C>T	ENST00000338469.3	-	4	590	c.487G>A	c.(487-489)Gag>Aag	p.E163K	TREM2_ENST00000373122.4_3'UTR|TREM2_ENST00000373113.3_Silent_p.L227L	NM_001271821.1	NP_001258750.1	Q9NZC2	TREM2_HUMAN	triggering receptor expressed on myeloid cells 2	162					axon guidance|humoral immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(2)|large_intestine(4)|lung(2)|ovary(1)|pancreas(1)	11	Ovarian(28;0.0418)|Colorectal(47;0.196)					ACGTGTCTCTCAGCCCTGCAA	0.612000													76	22					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22156102	22156102	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr19:22156102C>G	ENST00000397126.4	-	4	1882	c.1734G>C	c.(1732-1734)gaG>gaC	p.E578D	ZNF208_ENST00000601773.1_Intron|ZNF208_ENST00000599916.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				TGTAGGGTTTCTCTACAGTAT	0.353000													3	9					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179430194	179430194	+	Missense_Mutation	SNP	A	A	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr2:179430194A>G	ENST00000589042.1	-	326	80889	c.80665T>C	c.(80665-80667)Tat>Cat	p.Y26889H	TTN_ENST00000591111.1_Missense_Mutation_p.Y25248H|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.Y18016H|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.Y17824H|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.Y17949H|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.Y24321H|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000590932.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	25248	Fibronectin type-III 95.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGGATACTATATGTGTTAAAT	0.383000													21	33					0	0	1	0	0
NAPSA	9476	broad.mit.edu	37	19	50865444	50865444	+	Silent	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr19:50865444G>C	ENST00000253719.2	-	2	418	c.210C>G	c.(208-210)ctC>ctG	p.L70L	NR1H2_ENST00000542413.1_Intron|NR1H2_ENST00000600978.1_Intron	NM_004851.1	NP_004842.1	O96009	NAPSA_HUMAN	napsin A aspartic peptidase	70					proteolysis	extracellular region	aspartic-type endopeptidase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|skin(3)	12		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00743)|GBM - Glioblastoma multiforme(134;0.0183)		TGTAGTTCGAGAGAGGTACGA	0.582000													5	49					0	0	1	0	0
CEP192	55125	broad.mit.edu	37	18	13069762	13069762	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr18:13069762C>T	ENST00000506447.1	+	27	5161	c.5081C>T	c.(5080-5082)tCa>tTa	p.S1694L	CEP192_ENST00000325971.8_Missense_Mutation_p.S1098L|CEP192_ENST00000430049.2_Missense_Mutation_p.S1219L	NM_032142.3	NP_115518.3	B7ZMF0	B7ZMF0_HUMAN	centrosomal protein 192kDa	1289										NS(1)|breast(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(36)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						AGTCACTTTTCAGTGGATCCA	0.398000													15	22					0	0	1	0	0
ZNF518B	85460	broad.mit.edu	37	4	10446221	10446221	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr4:10446221C>G	ENST00000326756.3	-	3	2170	c.1732G>C	c.(1732-1734)Gag>Cag	p.E578Q		NM_053042.2	NP_444270.2	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	578					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(16)|ovary(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	42						TTGTGTTCCTCTGTCTGGTTA	0.378000													28	17					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100684592	100684592	+	Missense_Mutation	SNP	A	A	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr7:100684592A>G	ENST00000306151.4	+	3	9959	c.9895A>G	c.(9895-9897)Agc>Ggc	p.S3299G		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	3299	59 X approximate tandem repeats.|Ser-rich.		S -> N (in dbSNP:rs35988443).			extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					TTCTGAAACGAGCACCCTTTC	0.507000													36	332					0	0	1	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274291	39274291	+	Missense_Mutation	SNP	T	T	C	rs149439944	by1000genomes	TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr17:39274291T>C	ENST00000391413.2	-	1	315	c.277A>G	c.(277-279)Atg>Gtg	p.M93V		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	93	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament		p.M93V(4)		endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			TGGCAGCACATAGACTGGCAG	0.662000													4	59					0	0	1	0	0
FAM102B	284611	broad.mit.edu	37	1	109143230	109143230	+	Silent	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr1:109143230C>T	ENST00000370035.3	+	2	520	c.180C>T	c.(178-180)ttC>ttT	p.F60F	FAM102B_ENST00000405454.1_Silent_p.F60F	NM_001010883.2	NP_001010883.2	Q5T8I3	F102B_HUMAN	family with sequence similarity 102, member B	60										autonomic_ganglia(1)|kidney(1)|large_intestine(1)|lung(1)|skin(1)	5		all_epithelial(167;5.52e-05)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0217)|Lung(183;0.109)|COAD - Colon adenocarcinoma(174;0.141)|Epithelial(280;0.182)		GAAAGAAGTTCTCATTTATGT	0.378000													10	12					0	0	1	0	0
TMCO4	255104	broad.mit.edu	37	1	20097954	20097954	+	Missense_Mutation	SNP	C	C	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr1:20097954C>A	ENST00000294543.6	-	5	442	c.201G>T	c.(199-201)atG>atT	p.M67I	TMCO4_ENST00000375122.2_Missense_Mutation_p.M67I|TMCO4_ENST00000375127.1_Missense_Mutation_p.M67I	NM_181719.4	NP_859070.3	Q5TGY1	TMCO4_HUMAN	transmembrane and coiled-coil domains 4	67						integral to membrane				biliary_tract(1)|breast(2)|endometrium(2)|kidney(1)|lung(11)|skin(1)|upper_aerodigestive_tract(1)	19		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00708)|COAD - Colon adenocarcinoma(152;2.28e-05)|BRCA - Breast invasive adenocarcinoma(304;5.8e-05)|Kidney(64;0.000367)|GBM - Glioblastoma multiforme(114;0.000377)|KIRC - Kidney renal clear cell carcinoma(64;0.00459)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0862)|Lung(427;0.223)		CCAGGCCTGCCATGAACTCTG	0.542000													17	9					9.16793e-09	1.02748e-08	1	1	0
FAM129A	116496	broad.mit.edu	37	1	184792383	184792383	+	Silent	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr1:184792383C>G	ENST00000367511.3	-	8	1096	c.903G>C	c.(901-903)ctG>ctC	p.L301L	FAM129A_ENST00000487074.1_5'UTR	NM_052966.2	NP_443198.1	Q9BZQ8	NIBAN_HUMAN	family with sequence similarity 129, member A	301					negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				autonomic_ganglia(1)|breast(1)|cervix(2)|endometrium(4)|large_intestine(6)|liver(1)|lung(22)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	45						GGCCCTTTGTCAGAGCTCTGC	0.448000													14	64					0	0	1	0	0
HDGFRP3	50810	broad.mit.edu	37	15	83876122	83876122	+	Silent	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr15:83876122G>C	ENST00000299633.4	-	1	648	c.45C>G	c.(43-45)gtC>gtG	p.V15V	RP11-382A20.4_ENST00000565495.1_RNA	NM_016073.3	NP_057157.1	Q9Y3E1	HDGR3_HUMAN		15	PWWP.				cell proliferation	nucleus	growth factor activity			kidney(1)|large_intestine(1)|lung(4)|prostate(1)	7						TCTTGGCGAAGACCAGGTCGC	0.721000													6	2					0	0	1	0	0
TECR	9524	broad.mit.edu	37	19	14675641	14675641	+	Missense_Mutation	SNP	A	A	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr19:14675641A>C	ENST00000600083.1	+	8	701	c.68A>C	c.(67-69)tAc>tCc	p.Y23S	TECR_ENST00000215567.5_Missense_Mutation_p.Y178S|TECR_ENST00000596073.1_Missense_Mutation_p.Y23S|TECR_ENST00000436007.2_Missense_Mutation_p.Y193S			Q9NZ01	TECR_HUMAN	trans-2,3-enoyl-CoA reductase	178					fatty acid elongation|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	integral to endoplasmic reticulum membrane	trans-2-enoyl-CoA reductase (NADPH) activity|very long-chain-acyl-CoA dehydrogenase activity			endometrium(1)|large_intestine(1)|ovary(1)	3						ATGGCCTATTACATCAATCAC	0.622000													8	26					0	0	1	0	0
DNAAF1	123872	broad.mit.edu	37	16	84209813	84209813	+	Missense_Mutation	SNP	A	A	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr16:84209813A>G	ENST00000378553.5	+	11	2097	c.1973A>G	c.(1972-1974)cAg>cGg	p.Q658R	DNAAF1_ENST00000563818.1_3'UTR	NM_178452.4	NP_848547.4	Q8NEP3	DAAF1_HUMAN	dynein, axonemal, assembly factor 1	658					axonemal dynein complex assembly|cilium morphogenesis	cilium axoneme|cytoplasm|spindle pole	dynein binding			NS(1)|endometrium(7)|kidney(1)|large_intestine(6)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|stomach(4)|urinary_tract(1)	41						CCCTCTGGCCAGCTACTGATG	0.552000													7	22					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58154324	58154324	+	Silent	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr3:58154324C>T	ENST00000295956.4	+	44	7521	c.7356C>T	c.(7354-7356)atC>atT	p.I2452I	FLNB-AS1_ENST00000488720.1_RNA|FLNB_ENST00000484981.1_3'UTR|FLNB_ENST00000490882.1_Silent_p.I2483I|FLNB_ENST00000358537.3_Silent_p.I2428I|FLNB_ENST00000429972.2_Silent_p.I2441I|FLNB_ENST00000419752.2_Silent_p.I2272I|FLNB_ENST00000357272.4_3'UTR|FLNB_ENST00000493452.1_Silent_p.I2259I|FLNB_ENST00000348383.5_Silent_p.I2411I	NM_001457.3	NP_001448.2	O75369	FLNB_HUMAN	filamin B, beta	2452	Interaction with INPPL1.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		ACTACCTGATCAGCGTCAAAT	0.527000													14	19					0	0	1	0	0
ACTL6B	51412	broad.mit.edu	37	7	100252740	100252740	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr7:100252740C>T	ENST00000160382.5	-	4	377	c.271G>A	c.(271-273)Gag>Aag	p.E91K		NM_016188.4	NP_057272.1	O94805	ACL6B_HUMAN	actin-like 6B	91					chromatin modification|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nBAF complex|SWI/SNF complex	ATP binding|protein binding|structural constituent of cytoskeleton			endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|skin(1)	13	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					TCCCAGTCCTCGACTGGGGCC	0.597000													4	23					0	0	1	0	0
CEP112	201134	broad.mit.edu	37	17	64128821	64128821	+	Silent	SNP	T	T	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr17:64128821T>C	ENST00000392769.2	-	5	749	c.531A>G	c.(529-531)agA>agG	p.R177R	CEP112_ENST00000537949.1_Silent_p.R177R|CEP112_ENST00000535342.2_Silent_p.R177R	NM_145036.3	NP_659473.2	Q8N8E3	CE112_HUMAN	centrosomal protein 112kDa	177						centrosome				NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(8)|lung(11)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	28						GTCCATCTTCTCTGTGAGTTG	0.358000													3	21					0	0	1	0	0
GPX7	2882	broad.mit.edu	37	1	53072500	53072500	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr1:53072500G>C	ENST00000361314.4	+	2	321	c.283G>C	c.(283-285)Gac>Cac	p.D95H	GPX7_ENST00000459779.1_3'UTR	NM_015696.4	NP_056511.2	Q96SL4	GPX7_HUMAN	glutathione peroxidase 7	95					response to oxidative stress	extracellular region	glutathione peroxidase activity			breast(1)|kidney(1)|lung(4)|upper_aerodigestive_tract(1)	7					Glutathione(DB00143)	ACAGGAGCCTGACAGCAACAA	0.592000													12	66					0	0	1	0	0
ABCC2	1244	broad.mit.edu	37	10	101604195	101604195	+	Silent	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr10:101604195C>T	ENST00000370449.4	+	28	4073	c.3960C>T	c.(3958-3960)atC>atT	p.I1320I		NM_000392.3	NP_000383	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	1320	ABC transporter 2.					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(5)|endometrium(9)|kidney(2)|large_intestine(20)|liver(1)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	67		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	TCAGAGGGATCACTTGTGACA	0.532000													17	41					0	0	1	0	0
ZXDB	158586	broad.mit.edu	37	X	57619078	57619078	+	Silent	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chrX:57619078C>G	ENST00000374888.1	+	1	810	c.597C>G	c.(595-597)gcC>gcG	p.A199A		NM_007157.3	NP_009088.1	P98169	ZXDB_HUMAN	zinc finger, X-linked, duplicated B	199					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(2)|skin(6)	27						AGCCAGGGGCCGCTCCTGCCC	0.701000													5	7					0	0	1	0	0
OR4D11	219986	broad.mit.edu	37	11	59271379	59271379	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr11:59271379G>C	ENST00000313253.1	+	1	331	c.331G>C	c.(331-333)Gac>Cac	p.D111H		NM_001004706.1	NP_001004706.1	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D, member 11	111					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29						TGGTGGGGCAGACATTTTTTC	0.478000													23	48					0	0	1	0	0
PNKD	25953	broad.mit.edu	37	2	219136173	219136173	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr2:219136173C>T	ENST00000273077.4	+	2	188	c.137C>T	c.(136-138)tCc>tTc	p.S46F	PNKD_ENST00000248451.3_Missense_Mutation_p.S46F|PNKD_ENST00000472650.1_3'UTR	NM_015488.4	NP_056303.3	Q8N490	PNKD_HUMAN	paroxysmal nonkinesigenic dyskinesia	46						membrane|mitochondrion|nucleus	hydroxyacylglutathione hydrolase activity|zinc ion binding			NS(1)|endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|skin(2)	10		Renal(207;0.0474)		Epithelial(149;7.33e-07)|all cancers(144;0.000133)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGCCACAGCTCCCCAGAGGGC	0.572000													52	21					0	0	1	0	0
IRS2	8660	broad.mit.edu	37	13	110437768	110437768	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr13:110437768C>G	ENST00000375856.3	-	1	1147	c.633G>C	c.(631-633)aaG>aaC	p.K211N		NM_003749.2	NP_003740.2	Q9Y4H2	IRS2_HUMAN	insulin receptor substrate 2	211	IRS-type PTB.				fibroblast growth factor receptor signaling pathway|glucose metabolic process|insulin receptor signaling pathway|lipid homeostasis|negative regulation of B cell apoptosis|negative regulation of kinase activity|negative regulation of plasma membrane long-chain fatty acid transport|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of B cell proliferation|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|response to glucose stimulus	cytosol|plasma membrane	insulin receptor binding|signal transducer activity			kidney(2)|large_intestine(2)|lung(8)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	19	all_cancers(4;7.57e-15)|all_epithelial(4;5.91e-09)|all_lung(23;7.64e-07)|Lung NSC(43;0.000183)|Colorectal(4;0.00159)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0155)	Breast(118;0.159)	all cancers(43;0.00815)|BRCA - Breast invasive adenocarcinoma(86;0.11)|Epithelial(84;0.127)|GBM - Glioblastoma multiforme(44;0.147)			CCGTCAGGTTCTTGCTCTGGC	0.662000													8	17					0	0	1	0	0
DPP6	1804	broad.mit.edu	37	7	154684052	154684052	+	Silent	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr7:154684052G>A	ENST00000404039.1	+	26	2855	c.2268G>A	c.(2266-2268)ccG>ccA	p.P756P	DPP6_ENST00000332007.3_Silent_p.P758P|DPP6_ENST00000427557.1_Silent_p.P713P|DPP6_ENST00000377770.3_Silent_p.P820P	NM_001039350.1|NM_001936.3|NM_130797.2	NP_001034439.1|NP_001927.3|NP_570629.2	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6	820					cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			NS(3)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(35)|pancreas(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	71	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			AGATTTACCCGGACGAAAGCC	0.517000													18	37					0	0	1	0	0
SYNPO2	171024	broad.mit.edu	37	4	119948266	119948266	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr4:119948266G>C	ENST00000307142.4	+	3	938	c.742G>C	c.(742-744)Gag>Cag	p.E248Q	SYNPO2_ENST00000429713.2_Missense_Mutation_p.E248Q|SYNPO2_ENST00000434046.2_Missense_Mutation_p.E248Q|SYNPO2_ENST00000448416.2_Intron	NM_133477.2	NP_597734.2	Q9UMS6	SYNP2_HUMAN	synaptopodin 2	248						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(18)|ovary(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						CCCTACTAATGAGAAAGCAGA	0.483000													20	10					0	0	1	0	0
STYXL1	51657	broad.mit.edu	37	7	75643144	75643144	+	Silent	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr7:75643144G>A	ENST00000451157.1	-	5	538	c.369C>T	c.(367-369)ccC>ccT	p.P123P	STYXL1_ENST00000431581.1_Silent_p.P123P|STYXL1_ENST00000340062.5_Intron|STYXL1_ENST00000360591.3_Intron|STYXL1_ENST00000460184.2_5'UTR|STYXL1_ENST00000359697.3_Silent_p.P123P|STYXL1_ENST00000248600.1_Silent_p.P123P			Q9Y6J8	STYL1_HUMAN	serine/threonine/tyrosine interacting-like 1	123	Rhodanese.				intracellular signal transduction|protein dephosphorylation	intracellular	protein binding|protein tyrosine/serine/threonine phosphatase activity			endometrium(1)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(1)	10						GGATGTAGACGGGGTGGTGGG	0.547000													84	100					0	0	1	0	0
SCN3A	6328	broad.mit.edu	37	2	166032871	166032871	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr2:166032871C>T	ENST00000360093.3	-	3	525	c.34G>A	c.(34-36)Gaa>Aaa	p.E12K	SCN3A_ENST00000409101.3_Missense_Mutation_p.E12K|SCN3A_ENST00000283254.7_Missense_Mutation_p.E12K	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	12						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	CGGAAGCTTTCAGGTCCTGGG	0.418000													35	48					0	0	1	0	0
RIOK3	8780	broad.mit.edu	37	18	21044225	21044225	+	Missense_Mutation	SNP	C	C	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr18:21044225C>A	ENST00000339486.3	+	4	998	c.381C>A	c.(379-381)agC>agA	p.S127R	RIOK3_ENST00000577501.1_Missense_Mutation_p.S127R|RIOK3_ENST00000581585.1_Missense_Mutation_p.S111R	NM_003831.3	NP_003822.2	O14730	RIOK3_HUMAN	RIO kinase 3	127					chromosome segregation		ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|kidney(3)|large_intestine(1)|lung(3)|ovary(2)	10	all_cancers(21;0.000106)|all_epithelial(16;6.74e-07)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0202)|Ovarian(20;0.127)					ACAGCGATAGCTCTGAAGATG	0.393000													8	8					0.000442599	0.000464305	1	1	0
TBP	6908	broad.mit.edu	37	6	170866126	170866126	+	Silent	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr6:170866126G>A	ENST00000392092.2	+	2	288	c.9G>A	c.(7-9)caG>caA	p.Q3Q	TBP_ENST00000540980.1_Intron|TBP_ENST00000230354.6_Silent_p.Q3Q	NM_003194.4	NP_003185.1	P20226	TBP_HUMAN	TATA box binding protein	3					cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(1)	26		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		TCATGGATCAGAACAACAGCC	0.493000													12	54					0	0	1	0	0
HIRA	7290	broad.mit.edu	37	22	19365415	19365415	+	Silent	SNP	T	T	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr22:19365415T>C	ENST00000263208.5	-	14	1846	c.1590A>G	c.(1588-1590)gcA>gcG	p.A530A	HIRA_ENST00000546308.1_Silent_p.A486A|HIRA_ENST00000541063.1_Silent_p.A486A|HIRA_ENST00000340170.4_Silent_p.A530A	NM_003325.3	NP_003316.3	P54198	HIRA_HUMAN	histone cell cycle regulator	530	Interaction with CCNA1.				chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(2)|prostate(1)|skin(1)	37	Colorectal(54;0.0993)					CAGAATCGCCTGCAGGTCTGG	0.542000													70	46					0	0	1	0	0
PKD1L2	114780	broad.mit.edu	37	16	81232541	81232541	+	RNA	SNP	G	G	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr16:81232541G>T	ENST00000337114.4	-	0	1268				PKD1L2_ENST00000525539.1_RNA	NM_001076780.1	NP_001070248.1	Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2						neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						TCTCCAGGCGGTGCCTCCCAG	0.577000													61	29					2.02627e-32	2.39071e-32	1	1	0
ITGA9	3680	broad.mit.edu	37	3	37792018	37792018	+	Silent	SNP	C	C	G	rs145492361		TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr3:37792018C>G	ENST00000264741.5	+	23	2755	c.2499C>G	c.(2497-2499)ctC>ctG	p.L833L	AC093415.2_ENST00000449586.1_RNA	NM_002207.2	NP_002198.2	Q13797	ITA9_HUMAN	integrin, alpha 9	833					axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(17)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|urinary_tract(1)	44				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		CTAATCGACTCTCATCTGGTG	0.483000													6	66					0	0	1	0	0
HIPK2	28996	broad.mit.edu	37	7	139257861	139257861	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr7:139257861G>C	ENST00000406875.3	-	15	3503	c.3409C>G	c.(3409-3411)Cca>Gca	p.P1137A	HIPK2_ENST00000428878.2_Missense_Mutation_p.P1110A	NM_022740.4	NP_073577.3	Q9H2X6	HIPK2_HUMAN	homeodomain interacting protein kinase 2	1137	Autoinhibitory domain (AID).				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of BMP signaling pathway|positive regulation of JNK cascade|positive regulation of transforming growth factor beta receptor signaling pathway|SMAD protein signal transduction|transcription, DNA-dependent|virus-host interaction	centrosome|nuclear membrane|PML body	ATP binding|protein serine/threonine kinase activity|SMAD binding|transcription corepressor activity|virion binding			breast(4)|central_nervous_system(4)|endometrium(7)|kidney(2)|large_intestine(5)|lung(11)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Melanoma(164;0.205)					ATGCTGGCTGGGTAGGCAGTG	0.701000													7	8					0	0	1	0	0
GIMAP2	26157	broad.mit.edu	37	7	150389858	150389858	+	Missense_Mutation	SNP	G	G	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr7:150389858G>T	ENST00000223293.5	+	3	578	c.484G>T	c.(484-486)Gac>Tac	p.D162Y		NM_015660.2	NP_056475.1	Q9UG22	GIMA2_HUMAN	GTPase, IMAP family member 2	162						integral to membrane	GTP binding			kidney(1)|large_intestine(1)|lung(8)|skin(2)|urinary_tract(1)	13			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TTACATGCACGACTCAGATAA	0.502000													4	49					0.00909568	0.00930369	1	1	0
DMXL1	1657	broad.mit.edu	37	5	118582714	118582714	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr5:118582714C>G	ENST00000311085.8	+	43	8964	c.8884C>G	c.(8884-8886)Ctt>Gtt	p.L2962V	DMXL1_ENST00000505312.1_3'UTR|DMXL1_ENST00000539542.1_Missense_Mutation_p.L2983V	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	2962										breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		TACCTTTGGTCTTCTCCATAC	0.403000													14	16					0	0	1	0	0
SRRM4	84530	broad.mit.edu	37	12	119588914	119588914	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr12:119588914C>T	ENST00000267260.4	+	10	1557	c.1169C>T	c.(1168-1170)tCc>tTc	p.S390F		NM_194286.3	NP_919262.2	A7MD48	SRRM4_HUMAN	serine/arginine repetitive matrix 4	390	Ser-rich.				cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	24						AAAGGGTGTTCCCGCAGCTCC	0.592000													7	42					0	0	1	0	0
HLA-DQB2	3120	broad.mit.edu	37	6	32725572	32725572	+	Silent	SNP	G	G	A	rs116284473	byFrequency	TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr6:32725572G>A	ENST00000435145.2	-	4	796	c.735C>T	c.(733-735)atC>atT	p.I245I	HLA-DQB2_ENST00000411527.1_Intron|HLA-DQB2_ENST00000437316.2_Silent_p.I245I			Q5SR06	Q5SR06_HUMAN	major histocompatibility complex, class II, DQ beta 2	216					antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|immune response	integral to membrane|MHC class II protein complex				endometrium(1)|kidney(1)|lung(1)|prostate(2)	5						TGTGACGGATGATAAGGCCCA	0.557000													7	23					0	0	1	0	0
PBRM1	55193	broad.mit.edu	37	3	52595922	52595922	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr3:52595922C>G	ENST00000356770.4	-	24	4055	c.4053G>C	c.(4051-4053)atG>atC	p.M1351I	PBRM1_ENST00000394830.3_Missense_Mutation_p.M1331I|PBRM1_ENST00000409114.3_Missense_Mutation_p.M1398I|PBRM1_ENST00000410007.1_Missense_Mutation_p.M1358I|PBRM1_ENST00000296302.7_Missense_Mutation_p.M1383I|PBRM1_ENST00000409767.1_Missense_Mutation_p.M1398I|PBRM1_ENST00000409057.1_Missense_Mutation_p.M1383I|SMIM4_ENST00000476842.1_Intron|PBRM1_ENST00000337303.4_Missense_Mutation_p.M1383I			Q86U86	PB1_HUMAN	polybromo 1	1383					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			breast(5)|endometrium(5)|kidney(301)|liver(1)|lung(22)|pancreas(1)	335				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		TGTAGCCACTCATGTTGATTT	0.498000			"""Mis, N, F, S, D, O"""		"""clear cell renal carcinoma, breast"""								10	80					0	0	1	0	0
ACKR3	57007	broad.mit.edu	37	2	237489981	237489981	+	Silent	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr2:237489981C>T	ENST00000272928.3	+	2	1183	c.873C>T	c.(871-873)caC>caT	p.H291H		NM_020311.2	NP_064707.1			atypical chemokine receptor 3																		GGCTGGAGCACGCCCTCTTCA	0.592000													19	39					0	0	1	0	0
ZEB1	6935	broad.mit.edu	37	10	31810098	31810098	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr10:31810098C>T	ENST00000446923.2	+	7	2178	c.1787C>T	c.(1786-1788)tCa>tTa	p.S596L	ZEB1_ENST00000361642.5_Missense_Mutation_p.S613L|ZEB1_ENST00000560721.2_Missense_Mutation_p.S592L|ZEB1_ENST00000542815.3_Missense_Mutation_p.S545L|ZEB1_ENST00000320985.10_Missense_Mutation_p.S612L|ZEB1_ENST00000559858.1_3'UTR	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	612					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				GAAGAGCTCTCAAAAATTGCT	0.403000													15	25					0	0	1	0	0
ZNF785	146540	broad.mit.edu	37	16	30596527	30596527	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr16:30596527C>T	ENST00000395216.2	-	2	409	c.250G>A	c.(250-252)Gaa>Aaa	p.E84K	ZNF785_ENST00000470110.1_Missense_Mutation_p.E84K	NM_152458.6	NP_689671.2	A8K8V0	ZN785_HUMAN	zinc finger protein 785	84	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|lung(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	9						GCCTCCACTTCTCCTTCCACC	0.577000													13	16					0	0	1	0	0
HMP19	51617	broad.mit.edu	37	5	173491271	173491271	+	Nonsense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr5:173491271C>T	ENST00000303177.3	+	3	428	c.166C>T	c.(166-168)Cag>Tag	p.Q56*	NSG2_ENST00000521959.1_3'UTR|NSG2_ENST00000521585.1_Nonsense_Mutation_p.Q56*	NM_015980.4	NP_057064.1																					TCAGCCGGAACAGAAGAACAA	0.433000													15	23					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56407332	56407332	+	Silent	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr19:56407332G>A	ENST00000342929.3	-	11	3110	c.3111C>T	c.(3109-3111)tgC>tgT	p.C1037C	NLRP13_ENST00000588751.1_Intron	NM_176810.2	NP_789780.2	Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	1037				KALKKSTCRLQKLG -> FKKTCTM (in Ref. 2; DAA01241).			ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		TCTGCAGCCTGCATGTCGACT	0.463000													133	43					0	0	1	0	0
RIMKLB	57494	broad.mit.edu	37	12	8926243	8926243	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr12:8926243G>C	ENST00000357529.3	+	7	2286	c.1024G>C	c.(1024-1026)Gac>Cac	p.D342H	RIMKLB_ENST00000535829.1_Missense_Mutation_p.D342H|RIMKLB_ENST00000299673.5_Intron|RIMKLB_ENST00000538135.1_Missense_Mutation_p.D342H	NM_020734.2	NP_065785.2	Q9ULI2	RIMKB_HUMAN	ribosomal modification protein rimK-like family member B	342					protein modification process	cytoplasm	acid-amino acid ligase activity|ATP binding|metal ion binding			central_nervous_system(2)|kidney(3)|large_intestine(5)|lung(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	18						CACTGCTGTTGACAACATGAG	0.612000													28	87					0	0	1	0	0
ZNF135	7694	broad.mit.edu	37	19	58578380	58578380	+	Silent	SNP	A	A	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr19:58578380A>G	ENST00000506786.1	+	5	956	c.402A>G	c.(400-402)ccA>ccG	p.P134P	ZNF135_ENST00000313434.5_Silent_p.P176P|ZNF135_ENST00000401053.4_Silent_p.P200P|ZNF135_ENST00000359978.6_Silent_p.P188P|ZNF135_ENST00000511556.1_Silent_p.P188P|ZNF135_ENST00000439855.2_Silent_p.P176P			B4DHH9	B4DHH9_HUMAN	zinc finger protein 135	188					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(26)|ovary(1)|skin(1)|urinary_tract(1)	41		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0161)		CTGATCTCCCACATCAACCAA	0.507000													6	38					0	0	1	0	0
L3MBTL4	91133	broad.mit.edu	37	18	6311598	6311598	+	Silent	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr18:6311598C>T	ENST00000400104.3	-	3	227	c.27G>A	c.(25-27)aaG>aaA	p.K9K	L3MBTL4_ENST00000400105.2_Silent_p.K9K|L3MBTL4_ENST00000284898.6_Silent_p.K9K|L3MBTL4_ENST00000317931.7_Silent_p.K9K			Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4 (Drosophila)	9					chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		Colorectal(10;0.0249)				CCATATTAAGCTTCCTTTTCC	0.498000													49	88					0	0	1	0	0
DALRD3	55152	broad.mit.edu	37	3	49053596	49053596	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr3:49053596C>T	ENST00000440857.1	-	10	1525	c.823G>A	c.(823-825)Gat>Aat	p.D275N	DALRD3_ENST00000341949.4_Missense_Mutation_p.D442N|DALRD3_ENST00000441576.2_Missense_Mutation_p.D442N|DALRD3_ENST00000395462.4_Missense_Mutation_p.D275N|DALRD3_ENST00000313778.5_Missense_Mutation_p.D275N			Q5D0E6	DALD3_HUMAN	DALR anticodon binding domain containing 3	442					arginyl-tRNA aminoacylation	cytoplasm	arginine-tRNA ligase activity|ATP binding			breast(2)|endometrium(2)|large_intestine(2)|lung(5)|skin(1)	12				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CTCACCTCATCATGTAGCAGT	0.532000													19	26					0	0	1	0	0
WBSCR16	81554	broad.mit.edu	37	7	74486509	74486509	+	Silent	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr7:74486509C>T	ENST00000503250.2	-	2	468	c.399G>A	c.(397-399)ggG>ggA	p.G133G	WBSCR16_ENST00000543840.1_Silent_p.G133G|WBSCR16_ENST00000329959.4_Silent_p.G133G	NM_148842.2	NP_683682.1	Q96I51	WBS16_HUMAN	Williams-Beuren syndrome chromosome region 16	133										kidney(1)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	4						TGAGTCCCATCCCCCAGACTT	0.488000													11	59					0	0	1	0	0
KIAA0226	9711	broad.mit.edu	37	3	197421357	197421357	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr3:197421357C>T	ENST00000273582.5	-	11	1983	c.1438G>A	c.(1438-1440)Gag>Aag	p.E480K	KIAA0226_ENST00000389665.5_Missense_Mutation_p.E525K|KIAA0226_ENST00000296343.5_Missense_Mutation_p.E525K	NM_001145642.2	NP_001139114.1	Q92622	RUBIC_HUMAN	KIAA0226	525					autophagy|endocytosis|negative regulation of autophagy|negative regulation of endocytosis	early endosome|late endosome|lysosome	protein binding			NS(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_cancers(143;8.26e-10)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.0446)		CTGTCTTCCTCTTCCACTTCC	0.537000													43	29					0	0	1	0	0
FBXL7	23194	broad.mit.edu	37	5	15928335	15928335	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr5:15928335G>C	ENST00000504595.1	+	3	945	c.464G>C	c.(463-465)aGg>aCg	p.R155T	FBXL7_ENST00000329673.7_Missense_Mutation_p.R143T|FBXL7_ENST00000510662.1_Missense_Mutation_p.R108T	NM_001278317.1|NM_012304.3	NP_001265246.1|NP_036436.1	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	155	F-box.				ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(13)|lung(33)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	60						CGGCTCTGGAGGACTATCCGC	0.657000													12	9					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	39070663	39070663	+	Missense_Mutation	SNP	G	G	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr19:39070663G>T	ENST00000355481.4	+	99	14522	c.14391G>T	c.(14389-14391)ttG>ttT	p.L4797F	RYR1_ENST00000359596.3_Missense_Mutation_p.L4802F|RYR1_ENST00000360985.3_Missense_Mutation_p.L4797F	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	4802					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TGTCCCTCTTGGGACACTACA	0.587000													79	31					7.427e-35	8.78385e-35	1	1	0
SH3RF2	153769	broad.mit.edu	37	5	145439428	145439428	+	Splice_Site	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr5:145439428G>C	ENST00000511217.1	+	8	1607		c.e8-1		SH3RF2_ENST00000511705.1_Splice_Site|SH3RF2_ENST00000359120.4_Splice_Site			Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2								ligase activity|protein phosphatase 1 binding|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)	22			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TAATTCCCCAGATGGATCCCT	0.597000													17	15					0	0	1	0	0
ZNF366	167465	broad.mit.edu	37	5	71757279	71757279	+	Missense_Mutation	SNP	G	G	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr5:71757279G>T	ENST00000318442.5	-	2	535	c.45C>A	c.(43-45)ttC>ttA	p.F15L		NM_152625.1	NP_689838.1	Q8N895	ZN366_HUMAN	zinc finger protein 366	15					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	35		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		CAGCCAAGTCGAAATGCACAT	0.493000													8	18					0.000274275	0.000289578	1	1	0
DNMT3A	1788	broad.mit.edu	37	2	25458692	25458692	+	Silent	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr2:25458692G>A	ENST00000264709.3	-	22	2818	c.2481C>T	c.(2479-2481)ttC>ttT	p.F827F	DNMT3A_ENST00000380746.4_Silent_p.F638F|DNMT3A_ENST00000402667.1_Silent_p.F604F|DNMT3A_ENST00000474887.1_5'UTR|DNMT3A_ENST00000321117.5_Silent_p.F827F	NM_175629.2	NP_783328.1	Q9Y6K1	DNM3A_HUMAN	DNA (cytosine-5-)-methyltransferase 3 alpha	827					regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding	p.F827fs*4(1)		breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(964)|kidney(3)|large_intestine(10)|lung(29)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	1021	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCACTTTGCTGAACTAGATGA	0.448000			"""Mis, F, N, S"""		AML								17	26					0	0	1	0	0
PURA	5813	broad.mit.edu	37	5	139494117	139494117	+	Silent	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr5:139494117C>T	ENST00000331327.3	+	1	410	c.351C>T	c.(349-351)ttC>ttT	p.F117F		NM_005859.4	NP_005850.1	Q00577	PURA_HUMAN	purine-rich element binding protein A	117					DNA unwinding involved in replication|DNA-dependent DNA replication initiation	DNA replication factor A complex	double-stranded telomeric DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|single-stranded DNA binding|transcription factor binding			central_nervous_system(1)|lung(2)|ovary(1)|prostate(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGGCGACTTCATCGAGCACT	0.692000													8	3					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82578956	82578956	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr7:82578956C>T	ENST00000333891.9	-	6	11285	c.10948G>A	c.(10948-10950)Gat>Aat	p.D3650N	PCLO_ENST00000423517.2_Missense_Mutation_p.D3650N|PCLO_ENST00000437081.1_Missense_Mutation_p.D370N	NM_033026.5	NP_149015.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein						cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GGACTTATATCATCAGGGAGG	0.468000													28	110					0	0	1	0	0
SNRK	54861	broad.mit.edu	37	3	43384956	43384956	+	Silent	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr3:43384956C>T	ENST00000296088.7	+	6	1369	c.1065C>T	c.(1063-1065)atC>atT	p.I355I	SNRK_ENST00000437827.1_Silent_p.I149I|SNRK_ENST00000454177.1_Silent_p.I355I|SNRK_ENST00000429705.2_Silent_p.I355I	NM_017719.4	NP_060189.3	Q9NRH2	SNRK_HUMAN	SNF related kinase	355					myeloid cell differentiation	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(3)|ovary(5)|prostate(1)|skin(2)|stomach(1)	27				KIRC - Kidney renal clear cell carcinoma(284;0.0636)|Kidney(284;0.0792)		CGAGCAATATCAAGGCCCAGT	0.368000													14	34					0	0	1	0	0
KIF20B	9585	broad.mit.edu	37	10	91514296	91514296	+	Missense_Mutation	SNP	G	G	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr10:91514296G>T	ENST00000416354.1	+	26	4531	c.4459G>T	c.(4459-4461)Gct>Tct	p.A1487S	KIF20B_ENST00000260753.4_Missense_Mutation_p.A1417S|KIF20B_ENST00000478929.1_3'UTR|KIF20B_ENST00000371728.3_Missense_Mutation_p.A1457S|KIF20B_ENST00000394289.2_Missense_Mutation_p.A1457S			Q96Q89	KI20B_HUMAN	kinesin family member 20B	1457					cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	58						GAAATATAATGCTGATAGAAA	0.299000													8	10					4.68919e-08	5.16126e-08	1	1	0
EYA1	2138	broad.mit.edu	37	8	72246340	72246340	+	Nonsense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr8:72246340G>C	ENST00000340726.3	-	4	833	c.194C>G	c.(193-195)tCa>tGa	p.S65*	EYA1_ENST00000388742.4_Nonsense_Mutation_p.S65*|EYA1_ENST00000419131.1_Nonsense_Mutation_p.S65*|EYA1_ENST00000303824.7_Nonsense_Mutation_p.S65*|EYA1_ENST00000388743.2_Nonsense_Mutation_p.S65*|EYA1_ENST00000388741.2_Nonsense_Mutation_p.S32*|EYA1_ENST00000388740.3_Nonsense_Mutation_p.S32*	NM_000503.4	NP_000494.2	Q99502	EYA1_HUMAN	eyes absent homolog 1 (Drosophila)	65					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			NS(2)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(15)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	44	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			ACCTGAACCTGAGAAATTGTT	0.343000													19	7					0	0	1	0	0
MAPK6	5597	broad.mit.edu	37	15	52356167	52356167	+	Missense_Mutation	SNP	A	A	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr15:52356167A>T	ENST00000261845.5	+	6	1943	c.1136A>T	c.(1135-1137)cAg>cTg	p.Q379L	CTD-2184D3.5_ENST00000558607.1_RNA	NM_002748.3	NP_002739.1	Q16659	MK06_HUMAN	mitogen-activated protein kinase 6	379					cell cycle		ATP binding|MAP kinase activity			breast(3)|endometrium(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|skin(2)	20				all cancers(107;0.0028)		GATGAAGTTCAGCTTGATCCA	0.383000													5	31					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70504646	70504646	+	Missense_Mutation	SNP	A	A	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr1:70504646A>T	ENST00000310961.5	+	22	3458	c.3040A>T	c.(3040-3042)Acc>Tcc	p.T1014S	LRRC7_ENST00000035383.5_Missense_Mutation_p.T1009S|LRRC7_ENST00000415775.2_Missense_Mutation_p.T293S			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1009						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						TGAGATGCTCACCTACGGAAG	0.468000													4	22					0	0	1	0	0
DNAJC1	64215	broad.mit.edu	37	10	22048151	22048151	+	Missense_Mutation	SNP	C	C	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr10:22048151C>A	ENST00000376980.3	-	11	1834	c.1544G>T	c.(1543-1545)gGa>gTa	p.G515V		NM_022365.3	NP_071760.2	Q96KC8	DNJC1_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 1	515	SANT 2.				negative regulation of proteolysis|regulation of protein secretion|regulation of transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	ATPase activator activity|DNA binding|heat shock protein binding|unfolded protein binding			cervix(1)|endometrium(1)|large_intestine(2)|lung(13)|skin(2)|upper_aerodigestive_tract(2)	21		Breast(68;0.00869)|Prostate(175;0.0181)|Lung SC(717;0.0262)				GTCAGAGGATCCCCTTGGGTA	0.542000													20	93					6.33239e-15	7.36533e-15	1	1	0
DALRD3	55152	broad.mit.edu	37	3	49054938	49054938	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr3:49054938C>T	ENST00000440857.1	-	5	928	c.226G>A	c.(226-228)Gat>Aat	p.D76N	DALRD3_ENST00000341949.4_Missense_Mutation_p.D243N|DALRD3_ENST00000441576.2_Missense_Mutation_p.D243N|DALRD3_ENST00000395462.4_Missense_Mutation_p.D76N|DALRD3_ENST00000313778.5_Missense_Mutation_p.D76N			Q5D0E6	DALD3_HUMAN	DALR anticodon binding domain containing 3	243					arginyl-tRNA aminoacylation	cytoplasm	arginine-tRNA ligase activity|ATP binding			breast(2)|endometrium(2)|large_intestine(2)|lung(5)|skin(1)	12				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		GAGAGGAGATCCTCAGTCACT	0.572000													14	21					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21479006	21479006	+	Missense_Mutation	SNP	A	A	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr18:21479006A>G	ENST00000313654.9	+	46	6054	c.5813A>G	c.(5812-5814)aAa>aGa	p.K1938R	LAMA3_ENST00000269217.6_Missense_Mutation_p.K329R|LAMA3_ENST00000588770.1_3'UTR|LAMA3_ENST00000399516.3_Missense_Mutation_p.K1938R|LAMA3_ENST00000587184.1_Missense_Mutation_p.K329R	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	1938	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTGAAGATTAAAAATGTCATC	0.328000													4	11					0	0	1	0	0
HYLS1	219844	broad.mit.edu	37	11	125769995	125769995	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr11:125769995G>C	ENST00000425380.2	+	3	1513	c.732G>C	c.(730-732)caG>caC	p.Q244H	PUS3_ENST00000227474.3_Intron|HYLS1_ENST00000526028.1_Missense_Mutation_p.Q244H|HYLS1_ENST00000356438.3_Missense_Mutation_p.Q244H	NM_001134793.1	NP_001128265.1	Q96M11	HYLS1_HUMAN	hydrolethalus syndrome 1	244						centrosome|nucleus				breast(1)|endometrium(1)|large_intestine(3)|skin(3)|upper_aerodigestive_tract(1)	9	all_hematologic(175;0.177)	Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.131)|all_lung(97;0.139)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0446)		TCCGAGAGCAGATGCTTTGTC	0.473000													10	23					0	0	1	0	0
MDFIC	29969	broad.mit.edu	37	7	114655788	114655788	+	Silent	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr7:114655788G>A	ENST00000393486.1	+	5	1130	c.540G>A	c.(538-540)ctG>ctA	p.L180L	MDFIC_ENST00000257724.3_Silent_p.L289L	NM_001166345.1|NM_199072.4	NP_001159817.1|NP_951038.1	Q9P1T7	MDFIC_HUMAN	MyoD family inhibitor domain containing	180	Cys-rich.				activation of JUN kinase activity|interspecies interaction between organisms|negative regulation of protein import into nucleus|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|regulation of Wnt receptor signaling pathway|transcription, DNA-dependent	cytoplasm|nucleolus|nucleus	cyclin binding|Tat protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)	8						GCGAATTCCTGACCCTTTGCA	0.473000													118	112					0	0	1	0	0
C5orf42	65250	broad.mit.edu	37	5	37121857	37121857	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr5:37121857C>T	ENST00000274258.7	-	48	9166	c.5579G>A	c.(5578-5580)cGa>cAa	p.R1860Q	C5orf42_ENST00000512288.1_5'UTR|C5orf42_ENST00000508244.1_Missense_Mutation_p.R2962Q|C5orf42_ENST00000425232.2_Missense_Mutation_p.R2962Q			E9PH94	E9PH94_HUMAN	chromosome 5 open reading frame 42	2962										breast(5)|endometrium(3)|kidney(8)|large_intestine(24)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	79	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			TTGTGAGATTCGACGACTATA	0.413000													11	43					0	0	1	0	0
IPCEF1	26034	broad.mit.edu	37	6	154520812	154520812	+	Silent	SNP	G	G	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr6:154520812G>T	ENST00000265198.4	-	10	1052	c.897C>A	c.(895-897)atC>atA	p.I299I	IPCEF1_ENST00000422970.2_Silent_p.I300I|OPRM1_ENST00000337049.4_Intron|IPCEF1_ENST00000367220.4_Silent_p.I300I|IPCEF1_ENST00000519344.1_Silent_p.I271I	NM_001130700.1|NM_015553.2	NP_001124172.1|NP_056368.1			interaction protein for cytohesin exchange factors 1											breast(1)|central_nervous_system(2)|endometrium(3)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	12						CTTTGTCCATGATCTTTGATC	0.313000													3	30					1	1	1	1	0
RNF114	55905	broad.mit.edu	37	20	48558189	48558189	+	Missense_Mutation	SNP	G	G	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr20:48558189G>T	ENST00000244061.2	+	2	234	c.232G>T	c.(232-234)Gtg>Ttg	p.V78L		NM_018683.3	NP_061153.1	Q9Y508	RN114_HUMAN	ring finger protein 114	78					cell differentiation|multicellular organismal development|spermatogenesis	intracellular	zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(1)|ovary(1)	5						CGTCCGAGCCGTGGAGCTCGA	0.552000													34	128					2.42023e-17	2.82839e-17	1	1	0
CTNNA3	29119	broad.mit.edu	37	10	67829157	67829157	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr10:67829157C>G	ENST00000433211.2	-	15	2242	c.2068G>C	c.(2068-2070)Gag>Cag	p.E690Q	CTNNA3_ENST00000373744.4_Missense_Mutation_p.E690Q|CTNNA3_ENST00000373735.1_5'UTR	NM_013266.2	NP_037398.2	Q9UI47	CTNA3_HUMAN	catenin (cadherin-associated protein), alpha 3						cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(1)|lung(50)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	95						ATCTCAATCTCAGCATCCAGC	0.398000													9	43					0	0	1	0	0
BUD13	84811	broad.mit.edu	37	11	116633598	116633598	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr11:116633598G>A	ENST00000260210.4	-	4	730	c.707C>T	c.(706-708)tCa>tTa	p.S236L	BUD13_ENST00000375445.3_Intron	NM_032725.3	NP_116114.1	Q9BRD0	BUD13_HUMAN	BUD13 homolog (S. cerevisiae)	236	Arg-rich.									endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|pancreas(2)|skin(1)|urinary_tract(1)	22	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)		AGAGATATCTGAGGAACCATG	0.537000													76	36					0	0	1	0	0
HSPB9	94086	broad.mit.edu	37	17	40275183	40275183	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr17:40275183G>A	ENST00000355067.3	+	1	428	c.315G>A	c.(313-315)atG>atA	p.M105I	CTD-2132N18.3_ENST00000592574.1_Intron	NM_033194.2	NP_149971.1	Q9BQS6	HSPB9_HUMAN	heat shock protein, alpha-crystallin-related, B9	105					response to stress	cytoplasm|nucleus	protein binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)	4		all_cancers(22;0.00064)|Breast(137;0.00104)|all_epithelial(22;0.00866)		BRCA - Breast invasive adenocarcinoma(366;0.124)		ACCGGAAAATGCTCCCGTCCA	0.627000													8	85					0	0	1	0	0
MRE11A	4361	broad.mit.edu	37	11	94189501	94189501	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr11:94189501G>C	ENST00000323929.3	-	14	1726	c.1504C>G	c.(1504-1506)Cgt>Ggt	p.R502G	MRE11A_ENST00000323977.3_Missense_Mutation_p.R502G|MRE11A_ENST00000393241.4_Missense_Mutation_p.R502G|MRE11A_ENST00000407439.3_Missense_Mutation_p.R505G	NM_005591.3	NP_005582.1	P49959	MRE11_HUMAN	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	502					DNA duplex unwinding|double-strand break repair via homologous recombination|double-strand break repair via nonhomologous end joining|negative regulation of DNA endoreduplication|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|sister chromatid cohesion|telomere maintenance via telomerase	Mre11 complex|nucleoplasm	3'-5' exonuclease activity|double-stranded DNA binding|manganese ion binding|protein C-terminus binding|single-stranded DNA specific endodeoxyribonuclease activity			breast(5)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	29		Acute lymphoblastic leukemia(157;2.37e-05)|all_hematologic(158;0.00824)				CTGAAACGACGTACCTAGATC	0.313000								Homologous recombination	Ataxia-Telangiectasia-Like Disorder				5	1					0	0	1	0	0
PCDHA7	56141	broad.mit.edu	37	5	140214208	140214208	+	Missense_Mutation	SNP	G	G	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr5:140214208G>T	ENST00000525929.1	+	1	240	c.240G>T	c.(238-240)caG>caT	p.Q80H	PCDHA4_ENST00000512229.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA7_ENST00000378125.3_Missense_Mutation_p.Q80H|PCDHA2_ENST00000526136.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA6_ENST00000529310.1_Intron	NM_018910.2	NP_061733.1														NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TAAATCTGCAGAATGGCATTT	0.627000													29	161					1.13719e-10	1.29513e-10	1	1	0
DLC1	10395	broad.mit.edu	37	8	12948899	12948899	+	Missense_Mutation	SNP	T	T	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr8:12948899T>A	ENST00000276297.4	-	14	4192	c.3783A>T	c.(3781-3783)aaA>aaT	p.K1261N	DLC1_ENST00000512044.2_Missense_Mutation_p.K858N|DLC1_ENST00000510318.1_5'UTR|DLC1_ENST00000358919.2_Missense_Mutation_p.K824N|DLC1_ENST00000520226.1_Missense_Mutation_p.K750N	NM_182643.2	NP_872584.2	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1	1261	Rho-GAP.				actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						CATTCAAATCTTTCTGATCTG	0.403000													4	30					0	0	1	0	0
VWCE	220001	broad.mit.edu	37	11	61036431	61036431	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr11:61036431G>C	ENST00000335613.5	-	15	2231	c.1845C>G	c.(1843-1845)atC>atG	p.I615M	VWCE_ENST00000535710.1_Missense_Mutation_p.I80M	NM_152718.2	NP_689931.2	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	615	VWFC 4.					extracellular region	calcium ion binding			biliary_tract(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(17)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37						CAGGGATCCGGATCGGGTGAG	0.622000													4	21					0	0	1	0	0
OR6Y1	391112	broad.mit.edu	37	1	158517779	158517779	+	Silent	SNP	G	G	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr1:158517779G>T	ENST00000302617.3	-	1	116	c.117C>A	c.(115-117)acC>acA	p.T39T		NM_001005189.1	NP_001005189.1	Q8NGX8	OR6Y1_HUMAN	olfactory receptor, family 6, subfamily Y, member 1	39					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|kidney(1)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	30	all_hematologic(112;0.0378)					TCAGCAGATAGGTTGCCAGGA	0.458000													29	26					9.39395e-14	1.09005e-13	1	1	0
BAIAP3	8938	broad.mit.edu	37	16	1394662	1394662	+	Missense_Mutation	SNP	C	C	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr16:1394662C>A	ENST00000324385.5	+	19	1983	c.1825C>A	c.(1825-1827)Cag>Aag	p.Q609K	BAIAP3_ENST00000568887.1_Missense_Mutation_p.Q546K|BAIAP3_ENST00000426824.3_Missense_Mutation_p.Q574K|BAIAP3_ENST00000421665.2_Missense_Mutation_p.Q538K|BAIAP3_ENST00000397488.2_Missense_Mutation_p.Q591K|BAIAP3_ENST00000397489.1_Missense_Mutation_p.Q591K|BAIAP3_ENST00000562208.1_Missense_Mutation_p.Q551K	NM_003933.4	NP_003924.2	O94812	BAIP3_HUMAN	BAI1-associated protein 3	609					G-protein coupled receptor protein signaling pathway|neurotransmitter secretion		protein C-terminus binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(25)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42		Hepatocellular(780;0.0893)				TGATGACCTTCAGTTCTGCTA	0.652000													19	179					1.10513e-12	1.27635e-12	1	1	0
DST	667	broad.mit.edu	37	6	56469567	56469567	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr6:56469567C>T	ENST00000370754.5	-	39	9759	c.9760G>A	c.(9760-9762)Gat>Aat	p.D3254N	DST_ENST00000361203.3_Missense_Mutation_p.D3076N|DST_ENST00000370788.2_Intron|DST_ENST00000312431.6_Missense_Mutation_p.D3076N|DST_ENST00000244364.6_Intron|DST_ENST00000421834.2_Intron|DST_ENST00000370769.4_Missense_Mutation_p.D3076N|DST_ENST00000446842.2_Missense_Mutation_p.D2750N			Q03001	DYST_HUMAN	dystonin	3076					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TGCAGAAAATCATTTTTCCCA	0.348000													10	31					0	0	1	0	0
SLC38A4	55089	broad.mit.edu	37	12	47160509	47160509	+	Missense_Mutation	SNP	T	T	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr12:47160509T>A	ENST00000447411.1	-	16	1825	c.1619A>T	c.(1618-1620)gAt>gTt	p.D540V	SLC38A4_ENST00000266579.4_Missense_Mutation_p.D540V	NM_001143824.1	NP_001137296.1	Q969I6	S38A4_HUMAN	solute carrier family 38, member 4	540					cellular nitrogen compound metabolic process|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|skin(1)	21	Lung SC(27;0.192)|Renal(347;0.236)					ATTTGGAGGATCATAAATCCA	0.323000													3	13					0	0	1	0	0
RRBP1	6238	broad.mit.edu	37	20	17602401	17602401	+	Silent	SNP	C	C	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr20:17602401C>A	ENST00000377813.1	-	15	3561	c.3258G>T	c.(3256-3258)ctG>ctT	p.L1086L	RRBP1_ENST00000246043.4_Silent_p.L1086L|RRBP1_ENST00000360807.4_Silent_p.L653L|RRBP1_ENST00000455029.2_Silent_p.L427L|RRBP1_ENST00000377807.2_Silent_p.L653L|RRBP1_ENST00000470422.1_5'UTR			Q9P2E9	RRBP1_HUMAN	ribosome binding protein 1	1086					protein transport|translation|transmembrane transport	integral to endoplasmic reticulum membrane|ribosome	receptor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|prostate(6)	28						TGAGATCCTGCAGCCACTCGG	0.607000													12	19					0.0809354	0.0817663	1	1	0
TTI1	9675	broad.mit.edu	37	20	36634683	36634683	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr20:36634683C>T	ENST00000373448.2	-	4	2657	c.2419G>A	c.(2419-2421)Gaa>Aaa	p.E807K	TTI1_ENST00000373447.3_Missense_Mutation_p.E807K|TTI1_ENST00000449821.1_Missense_Mutation_p.E807K	NM_014657.1	NP_055472.1	O43156	TTI1_HUMAN	TELO2 interacting protein 1	807							binding			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	47						TCGATGTCTTCAGCTGTGGTG	0.428000													59	71					0	0	1	0	0
PTPRE	5791	broad.mit.edu	37	10	129845659	129845659	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr10:129845659C>G	ENST00000254667.3	+	4	394	c.115C>G	c.(115-117)Ccg>Gcg	p.P39A	PTPRE_ENST00000430713.2_Missense_Mutation_p.P39A|PTPRE_ENST00000471218.1_Missense_Mutation_p.P39A|PTPRE_ENST00000419012.2_Missense_Mutation_p.P39A	NM_006504.4	NP_006495.1	P23469	PTPRE_HUMAN	protein tyrosine phosphatase, receptor type, E	39					negative regulation of insulin receptor signaling pathway|protein phosphorylation	cytoplasm|integral to membrane|intermediate filament cytoskeleton|nucleus|plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	22		all_epithelial(44;1.66e-05)|all_lung(145;0.00456)|Lung NSC(174;0.0066)|all_neural(114;0.0936)|Colorectal(57;0.141)|Breast(234;0.166)|Melanoma(40;0.203)				TGCAGGCCCTCCGGACCCGGG	0.612000													10	10					0	0	1	0	0
C1orf64	149563	broad.mit.edu	37	1	16330856	16330856	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr1:16330856G>C	ENST00000329454.2	+	1	126	c.58G>C	c.(58-60)Gag>Cag	p.E20Q		NM_178840.2	NP_849162.1	Q8NEQ6	CA064_HUMAN	chromosome 1 open reading frame 64	20										breast(2)|endometrium(1)|lung(3)	6		Colorectal(325;0.000435)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;3.25e-07)|COAD - Colon adenocarcinoma(227;2.08e-05)|BRCA - Breast invasive adenocarcinoma(304;9.19e-05)|Kidney(64;0.000165)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.0114)|READ - Rectum adenocarcinoma(331;0.0649)		CACCATCCGTGAGACAGGCCT	0.642000													9	5					0	0	1	0	0
PARP6	56965	broad.mit.edu	37	15	72549769	72549769	+	Missense_Mutation	SNP	T	T	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr15:72549769T>C	ENST00000569795.1	-	13	1606	c.919A>G	c.(919-921)Act>Gct	p.T307A	PARP6_ENST00000287196.9_Missense_Mutation_p.T307A|PARP6_ENST00000413097.2_5'UTR|PARP6_ENST00000260376.7_Missense_Mutation_p.T307A			Q2NL67	PARP6_HUMAN	poly (ADP-ribose) polymerase family, member 6	307							NAD+ ADP-ribosyltransferase activity			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(8)|skin(1)|urinary_tract(1)	18						AGTTCACGAGTACAGACAGCT	0.527000													4	43					0	0	1	0	0
ZNF570	148268	broad.mit.edu	37	19	37975002	37975002	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr19:37975002G>C	ENST00000330173.1	+	5	1007	c.478G>C	c.(478-480)Gag>Cag	p.E160Q	ZNF570_ENST00000388801.3_5'UTR|ZNF570_ENST00000586475.1_Missense_Mutation_p.E216Q	NM_144694.1	NP_653295.1	Q96NI8	ZN570_HUMAN	zinc finger protein 570	160					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(3)|large_intestine(6)|lung(12)|ovary(1)|prostate(1)|skin(1)	27			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CCTTTTTGATGAGAGAGAACA	0.388000													14	120					0	0	1	0	0
TBC1D1	23216	broad.mit.edu	37	4	38016207	38016207	+	Silent	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr4:38016207C>T	ENST00000261439.4	+	3	850	c.495C>T	c.(493-495)ttC>ttT	p.F165F	TBC1D1_ENST00000508802.1_Silent_p.F165F	NM_001253914.1|NM_001253915.1|NM_015173.3	NP_001240843.1|NP_001240844.1|NP_055988.2	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	165						nucleus	Rab GTPase activator activity			NS(1)|breast(3)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	36						CGTCCGAGTTCGACGACACGT	0.627000													50	48					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179631277	179631277	+	Silent	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr2:179631277G>A	ENST00000589042.1	-	41	9758	c.9534C>T	c.(9532-9534)caC>caT	p.H3178H	TTN_ENST00000591111.1_Silent_p.H3178H|TTN_ENST00000342175.6_Silent_p.H3132H|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Silent_p.H3132H|TTN_ENST00000359218.5_Silent_p.H3132H|TTN_ENST00000342992.6_Silent_p.H3178H|TTN_ENST00000360870.5_Silent_p.H3178H|TTN-AS1_ENST00000610005.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	2913							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTTATACCAGTGGGCATCAA	0.383000													20	28					0	0	1	0	0
PLVAP	83483	broad.mit.edu	37	19	17476224	17476224	+	Missense_Mutation	SNP	C	C	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr19:17476224C>A	ENST00000252590.4	-	3	1111	c.1050G>T	c.(1048-1050)gaG>gaT	p.E350D		NM_031310.1	NP_112600.1	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	350						caveola|integral to membrane|perinuclear region of cytoplasm				cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						GCACCGCCTTCTCCTCCAGCG	0.617000													11	31					2.27111e-07	2.47209e-07	1	1	0
ARID1B	57492	broad.mit.edu	37	6	157502169	157502169	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr6:157502169G>A	ENST00000346085.5	+	12	3203	c.3202G>A	c.(3202-3204)Gag>Aag	p.E1068K	ARID1B_ENST00000275248.4_Missense_Mutation_p.E1050K|ARID1B_ENST00000367148.1_Missense_Mutation_p.E1108K|ARID1B_ENST00000478761.2_3'UTR|ARID1B_ENST00000350026.5_Missense_Mutation_p.E1055K	NM_020732.3	NP_065783.3	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1055	ARID.				chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			NS(2)|breast(5)|central_nervous_system(4)|endometrium(12)|kidney(4)|large_intestine(11)|lung(30)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(3)	81		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		GAATGAGCCAGAGAGAAAGCT	0.572000													5	21					0	0	1	0	0
KPNB1	3837	broad.mit.edu	37	17	45727766	45727766	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr17:45727766G>C	ENST00000290158.4	+	2	462	c.55G>C	c.(55-57)Gaa>Caa	p.E19Q	KPNB1_ENST00000535458.2_Intron|KPNB1_ENST00000577918.1_3'UTR	NM_001276453.1|NM_002265.4	NP_001263382.1|NP_002256.2	Q14974	IMB1_HUMAN	karyopherin (importin) beta 1	19					DNA fragmentation involved in apoptotic nuclear change|NLS-bearing substrate import into nucleus|protein import into nucleus, translocation|ribosomal protein import into nucleus|viral genome transport in host cell|viral infectious cycle	cytosol|nuclear pore|nucleoplasm	nuclear localization sequence binding|protein domain specific binding|zinc ion binding			breast(1)|ovary(1)|pancreas(1)|skin(1)	4						GCTGGAGCTGGAAGCGGCGCA	0.726000													3	10					0	0	1	0	0
GLS2	27165	broad.mit.edu	37	12	56868392	56868392	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr12:56868392C>T	ENST00000311966.4	-	12	1438	c.1160G>A	c.(1159-1161)cGc>cAc	p.R387H	GLS2_ENST00000476991.1_5'UTR	NM_013267.2	NP_037399.2	Q9UI32	GLSL_HUMAN	glutaminase 2 (liver, mitochondrial)	387					cellular amino acid biosynthetic process|glutamate secretion|glutamine metabolic process|neurotransmitter secretion	mitochondrial matrix	glutaminase activity|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	13					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GAGGGTGTTGCGCACTGCTTC	0.567000													7	80					0	0	1	0	0
CLSTN2	64084	broad.mit.edu	37	3	140285025	140285025	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr3:140285025G>A	ENST00000458420.3	+	17	2988	c.2798G>A	c.(2797-2799)aGa>aAa	p.R933K		NM_022131.2	NP_071414.2	Q9H4D0	CSTN2_HUMAN	calsyntenin 2	933					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|liver(1)|lung(42)|pancreas(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	87						GGGATGGGCAGAGGCAGACAT	0.612000										HNSCC(16;0.037)			5	17					0	0	1	0	0
RIPK4	54101	broad.mit.edu	37	21	43162085	43162085	+	Missense_Mutation	SNP	A	A	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr21:43162085A>T	ENST00000352483.2	-	9	1476	c.1412T>A	c.(1411-1413)aTg>aAg	p.M471K	RIPK4_ENST00000332512.3_Missense_Mutation_p.M423K|RIPK4_ENST00000544709.1_Missense_Mutation_p.M360K|RIPK4_ENST00000542057.1_Missense_Mutation_p.M360K			Q96T11	Q96T11_HUMAN	receptor-interacting serine-threonine kinase 4	423						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						CAGGATCTTCATCAGTTTGCT	0.627000													179	170					0	0	1	0	0
HDLBP	3069	broad.mit.edu	37	2	242169582	242169582	+	Silent	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr2:242169582G>A	ENST00000391975.1	-	26	3804	c.3577C>T	c.(3577-3579)Ctg>Ttg	p.L1193L	HDLBP_ENST00000310931.4_Silent_p.L1193L|HDLBP_ENST00000427183.2_Silent_p.L1160L|HDLBP_ENST00000391976.2_Silent_p.L1193L	NM_203346.3	NP_976221	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	1193	KH 14.				cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(7)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(11)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		TCCTCCTCCAGATTGAGGATG	0.632000													10	31					0	0	1	0	0
KIAA0556	23247	broad.mit.edu	37	16	27761480	27761480	+	Missense_Mutation	SNP	C	C	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr16:27761480C>A	ENST00000261588.4	+	16	3218	c.3199C>A	c.(3199-3201)Cct>Act	p.P1067T		NM_015202.2	NP_056017.2	O60303	K0556_HUMAN	KIAA0556	1067										breast(4)|endometrium(7)|kidney(8)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	76						CTTCACGCACCCTTGCCACGT	0.542000													13	22					1.5842e-08	1.76741e-08	1	1	0
TPX2	22974	broad.mit.edu	37	20	30365345	30365345	+	Silent	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr20:30365345C>T	ENST00000340513.4	+	9	1314	c.786C>T	c.(784-786)ttC>ttT	p.F262F	TPX2_ENST00000300403.6_Silent_p.F262F			Q9ULW0	TPX2_HUMAN	TPX2, microtubule-associated	262					activation of protein kinase activity|apoptosis|cell division|cell proliferation|mitosis|regulation of mitotic spindle organization	cytoplasm|microtubule|nucleus|spindle pole	ATP binding|GTP binding|protein kinase binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28			Epithelial(4;0.000771)|Colorectal(19;0.00306)|all cancers(5;0.004)|COAD - Colon adenocarcinoma(19;0.0347)|OV - Ovarian serous cystadenocarcinoma(3;0.0656)			ACTTCCACTTCCGCACAGATG	0.418000													5	61					0	0	1	0	0
DPP3	10072	broad.mit.edu	37	11	66261098	66261098	+	Missense_Mutation	SNP	C	C	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr11:66261098C>A	ENST00000532677.1	+	12	1841	c.1440C>A	c.(1438-1440)ttC>ttA	p.F480L	DPP3_ENST00000533799.1_3'UTR|DPP3_ENST00000541961.1_Missense_Mutation_p.F461L|DPP3_ENST00000453114.1_Missense_Mutation_p.F461L|DPP3_ENST00000360510.2_Missense_Mutation_p.F461L|DPP3_ENST00000530165.1_Missense_Mutation_p.F431L|DPP3_ENST00000531863.1_Missense_Mutation_p.F481L	NM_001256670.1|NM_005700.4|NM_130443.3	NP_001243599.1|NP_005691.2|NP_569710.2	Q9NY33	DPP3_HUMAN	dipeptidyl-peptidase 3	461					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)	23						GCAAGCTCTTCGTACAGGTGA	0.642000													11	3					3.86212e-05	4.11291e-05	1	1	0
DNAH8	1769	broad.mit.edu	37	6	38893923	38893923	+	Silent	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr6:38893923C>G	ENST00000359357.3	+	72	10658	c.10404C>G	c.(10402-10404)ctC>ctG	p.L3468L	DNAH8_ENST00000441566.1_Silent_p.L3432L|DNAH8_ENST00000449981.2_Silent_p.L3685L|RP1-207H1.3_ENST00000418399.1_RNA|RP1-207H1.3_ENST00000416948.1_RNA					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						ACCCACTCCTCATAGACCCAC	0.413000													45	18					0	0	1	0	0
OR52B4	143496	broad.mit.edu	37	11	4388619	4388619	+	Nonsense_Mutation	SNP	C	C	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr11:4388619C>A	ENST00000408920.2	-	1	997	c.907G>T	c.(907-909)Gaa>Taa	p.E303*		NM_001005161.3	NP_001005161.2	Q8NGK2	O52B4_HUMAN	olfactory receptor, family 52, subfamily B, member 4	303					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(2)|kidney(3)|large_intestine(7)|lung(15)|skin(2)	31		Medulloblastoma(188;0.0075)|Breast(177;0.0249)|all_neural(188;0.0577)		Epithelial(150;1.57e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0826)|LUSC - Lung squamous cell carcinoma(625;0.19)		ACCACCTGTTCCTGGATTTGC	0.398000													3	22					0.004672	0.00481892	1	1	0
ZNF366	167465	broad.mit.edu	37	5	71757131	71757131	+	Missense_Mutation	SNP	C	C	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr5:71757131C>A	ENST00000318442.5	-	2	683	c.193G>T	c.(193-195)Gat>Tat	p.D65Y		NM_152625.1	NP_689838.1	Q8N895	ZN366_HUMAN	zinc finger protein 366	65					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	35		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		GGGAACCCATCTAGGTCTCCT	0.582000													19	44					1.96292e-10	2.23039e-10	1	1	0
ZFHX3	463	broad.mit.edu	37	16	72831018	72831018	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr16:72831018G>C	ENST00000268489.5	-	9	6235	c.5563C>G	c.(5563-5565)Cag>Gag	p.Q1855E	ZFHX3_ENST00000397992.5_Missense_Mutation_p.Q941E	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	1855	Poly-Gln.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				AGTTGGTTCTGCTGCTGCTGC	0.532000													10	57					0	0	1	0	0
TTLL7	79739	broad.mit.edu	37	1	84369778	84369778	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr1:84369778G>A	ENST00000260505.8	-	18	2569	c.2192C>T	c.(2191-2193)tCt>tTt	p.S731F	TTLL7_ENST00000477524.1_5'UTR	NM_024686.4	NP_078962.4	Q6ZT98	TTLL7_HUMAN	tubulin tyrosine ligase-like family, member 7	731					cell differentiation|nervous system development|protein modification process	cilium|dendrite|microtubule basal body|perikaryon	tubulin-tyrosine ligase activity			kidney(1)|large_intestine(8)|lung(15)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29				all cancers(265;0.0126)|Epithelial(280;0.0372)|OV - Ovarian serous cystadenocarcinoma(397;0.16)		TTGTTTTACAGAGTCCAATTT	0.338000													15	16					0	0	1	0	0
WBSCR22	114049	broad.mit.edu	37	7	73111993	73111993	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr7:73111993G>C	ENST00000265758.2	+	11	818	c.760G>C	c.(760-762)Gag>Cag	p.E254Q	WBSCR22_ENST00000423497.1_Missense_Mutation_p.E271Q|WBSCR22_ENST00000423166.2_3'UTR	NM_017528.4	NP_059998.2	O43709	WBS22_HUMAN	Williams Beuren syndrome chromosome region 22	254						nucleus	methyltransferase activity			autonomic_ganglia(1)|large_intestine(2)|lung(9)|prostate(1)	13		Lung NSC(55;0.0908)|all_lung(88;0.198)				ATGGGTGCTGGAGAAGAAGGA	0.612000													11	25					0	0	1	0	0
VDR	7421	broad.mit.edu	37	12	48250914	48250914	+	Nonsense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr12:48250914G>C	ENST00000229022.3	-	7	862	c.581C>G	c.(580-582)tCa>tGa	p.S194*	VDR_ENST00000549336.1_Nonsense_Mutation_p.S194*|VDR_ENST00000550325.1_Nonsense_Mutation_p.S244*|VDR_ENST00000535672.1_Nonsense_Mutation_p.S162*|VDR_ENST00000395324.2_Nonsense_Mutation_p.S194*	NM_001017535.1	NP_001017535.1	P11473	VDR_HUMAN	vitamin D (1,25- dihydroxyvitamin D3) receptor	194	Ligand-binding.				decidualization|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of vitamin D 24-hydroxylase activity|regulation of calcidiol 1-monooxygenase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid X receptor binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|vitamin D3 receptor activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(10)|ovary(3)|skin(2)	22		Acute lymphoblastic leukemia(13;0.109)|all_hematologic(14;0.214)		GBM - Glioblastoma multiforme(48;0.17)	Calcidiol(DB00146)|Calcipotriol(DB02300)|Calcitriol(DB00136)|Dihydrotachysterol(DB01070)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	CTGCTTACCTGAAGAGGTGAT	0.607000													7	22					0	0	1	0	0
TBC1D1	23216	broad.mit.edu	37	4	38016321	38016321	+	Silent	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr4:38016321C>G	ENST00000261439.4	+	3	964	c.609C>G	c.(607-609)gtC>gtG	p.V203V	TBC1D1_ENST00000508802.1_Silent_p.V203V	NM_001253914.1|NM_001253915.1|NM_015173.3	NP_001240843.1|NP_001240844.1|NP_055988.2	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	203						nucleus	Rab GTPase activator activity			NS(1)|breast(3)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	36						TCAATCACGTCAGCGGCAGCC	0.682000													32	36					0	0	1	0	0
SNX19	399979	broad.mit.edu	37	11	130777856	130777856	+	Missense_Mutation	SNP	C	C	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr11:130777856C>A	ENST00000265909.4	-	5	2726	c.2157G>T	c.(2155-2157)aaG>aaT	p.K719N	SNX19_ENST00000530356.1_Missense_Mutation_p.K99N|SNX19_ENST00000533214.1_Missense_Mutation_p.K719N|SNX19_ENST00000533318.1_Intron|SNX19_ENST00000528555.1_Missense_Mutation_p.K99N|SNX19_ENST00000539184.1_Missense_Mutation_p.K162N|SNX19_ENST00000545537.1_Intron|SNX19_ENST00000534726.1_Intron	NM_014758.2	NP_055573	Q92543	SNX19_HUMAN	sorting nexin 19	719					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(8)|ovary(3)|prostate(1)|skin(6)|urinary_tract(1)	35	all_hematologic(175;0.0597)	Lung NSC(97;0.000272)|all_lung(97;0.000608)|Breast(109;0.000962)|all_neural(223;0.0298)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;0.0195)|Lung(977;0.233)		ACTTGCTAGCCTTCTTGCCTT	0.552000													11	74					0.0809354	0.0817663	1	1	0
TSPYL5	85453	broad.mit.edu	37	8	98289735	98289735	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr8:98289735G>A	ENST00000322128.3	-	1	441	c.338C>T	c.(337-339)tCg>tTg	p.S113L		NM_033512.2	NP_277047.2	Q86VY4	TSYL5_HUMAN	TSPY-like 5	113					cellular response to gamma radiation|nucleosome assembly|positive regulation of cell proliferation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|regulation of growth	nucleus	protein binding			cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|lung(3)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	20	Breast(36;2.56e-06)					CAGGCGCTCCGAGAGAGATGC	0.746000													9	11					0	0	1	0	0
MEGF8	1954	broad.mit.edu	37	19	42880206	42880206	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr19:42880206C>T	ENST00000334370.4	+	41	8251	c.7616C>T	c.(7615-7617)gCc>gTc	p.A2539V	MEGF8_ENST00000378073.4_Missense_Mutation_p.A200V|MEGF8_ENST00000251268.6_Missense_Mutation_p.A2606V	NM_001410.2	NP_001401.2	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	2606	Pro-rich.					integral to membrane	calcium ion binding|structural molecule activity			breast(2)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	50		Prostate(69;0.00682)				GAGCACCATGCCCTCAAGTCG	0.677000													12	122					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54307456	54307456	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr15:54307456G>C	ENST00000545554.1	+	1	2356	c.2356G>C	c.(2356-2358)Gac>Cac	p.D786H	UNC13C_ENST00000260323.11_Missense_Mutation_p.D786H|UNC13C_ENST00000537900.1_Missense_Mutation_p.D786H			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	786					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		ATTAAGCATTGACCTTTCTGA	0.418000													3	18					0	0	1	0	0
HEY1	23462	broad.mit.edu	37	8	80677792	80677792	+	Silent	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr8:80677792G>C	ENST00000337919.5	-	5	751	c.558C>G	c.(556-558)acC>acG	p.T186T	HEY1_ENST00000354724.3_Silent_p.T182T|HEY1_ENST00000523976.1_Silent_p.T92T|HEY1_ENST00000435063.2_5'UTR	NM_001040708.1	NP_001035798.1	Q9Y5J3	HEY1_HUMAN	hes-related family bHLH transcription factor with YRPW motif 1	182					angiogenesis|negative regulation of Notch signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|Notch signaling pathway|transcription, DNA-dependent	nucleus	DNA binding|protein binding		HEY1/NCOA2(10)	cervix(1)|kidney(2)|large_intestine(5)|lung(14)	22	all_lung(9;5.1e-05)		Epithelial(68;0.076)|all cancers(69;0.179)			GTCCGAAGACGGTCCCCCAGG	0.682000			T	NCOA2	mesenchymal chondrosarcoma						OREG0018837	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	61					0	0	1	0	0
SLC24A1	9187	broad.mit.edu	37	15	65917308	65917308	+	Missense_Mutation	SNP	G	G	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr15:65917308G>T	ENST00000261892.6	+	2	1177	c.890G>T	c.(889-891)gGg>gTg	p.G297V	SLC24A1_ENST00000544319.2_Missense_Mutation_p.G297V|SLC24A1_ENST00000339868.6_Missense_Mutation_p.G297V|SLC24A1_ENST00000537259.1_Missense_Mutation_p.G297V|SLC24A1_ENST00000546330.1_Missense_Mutation_p.G297V|SLC24A1_ENST00000399033.4_Missense_Mutation_p.G297V	NM_001254740.1|NM_004727.2	NP_001241669.1|NP_004718.1	O60721	NCKX1_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 1	297					response to light intensity|visual perception	integral to plasma membrane|membrane fraction|outer membrane	calcium, potassium:sodium antiporter activity|protein binding|symporter activity			breast(2)|endometrium(7)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23						CATCCCTGGGGGTTAGTGGGA	0.537000													11	76					2.10051e-16	2.44893e-16	1	1	0
OBSL1	23363	broad.mit.edu	37	2	220428173	220428173	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr2:220428173G>A	ENST00000404537.1	-	7	2640	c.2584C>T	c.(2584-2586)Cgc>Tgc	p.R862C	OBSL1_ENST00000289656.3_Missense_Mutation_p.R449C|OBSL1_ENST00000265318.4_Missense_Mutation_p.R862C|OBSL1_ENST00000603926.1_Missense_Mutation_p.R862C|OBSL1_ENST00000373873.4_Missense_Mutation_p.R862C|OBSL1_ENST00000373876.1_Missense_Mutation_p.R862C	NM_015311.2	NP_056126.1	O75147	OBSL1_HUMAN	obscurin-like 1	862	Ig-like 6.				cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity						Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		ACCAGGCGGCGATGGGGCCCC	0.642000													4	21					0	0	1	0	0
C5orf34	375444	broad.mit.edu	37	5	43494697	43494697	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr5:43494697C>G	ENST00000306862.2	-	7	1534	c.1159G>C	c.(1159-1161)Gag>Cag	p.E387Q	RP11-159F24.3_ENST00000505645.1_RNA	NM_198566.2	NP_940968	Q96MH7	CE034_HUMAN	chromosome 5 open reading frame 34	387										breast(2)|endometrium(2)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)|stomach(2)	21	Lung NSC(6;2.07e-05)					TAAGTTTTCTCTTCTCTCTGA	0.323000													5	24					0	0	1	0	0
IFI44	10561	broad.mit.edu	37	1	79116310	79116310	+	Missense_Mutation	SNP	C	C	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr1:79116310C>A	ENST00000370747.4	+	2	515	c.430C>A	c.(430-432)Cag>Aag	p.Q144K	IFI44_ENST00000545124.1_Intron|IFI44_ENST00000495254.1_Intron	NM_006417.4	NP_006408.3	Q8TCB0	IFI44_HUMAN	interferon-induced protein 44	144					response to virus	cytoplasm				central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	21						TATCTCTATTCAGGATTATGA	0.348000													26	9					0.000720815	0.000751358	1	1	0
PKD1L1	168507	broad.mit.edu	37	7	47835685	47835685	+	Missense_Mutation	SNP	T	T	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr7:47835685T>C	ENST00000289672.2	-	55	8307	c.8257A>G	c.(8257-8259)Aga>Gga	p.R2753G	C7orf69_ENST00000418326.2_Intron|C7orf69_ENST00000258776.4_Intron	NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	2753					cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						TCTTTAAGTCTCACAAAAGAT	0.358000													8	49					0	0	1	0	0
NLRP14	338323	broad.mit.edu	37	11	7064875	7064875	+	Nonsense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr11:7064875C>T	ENST00000299481.4	+	4	1964	c.1618C>T	c.(1618-1620)Cga>Tga	p.R540*		NM_176822.3	NP_789792.1	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	540					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			breast(3)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	21				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		GAATGAAGATCGAGTAAAACA	0.348000													26	5					0	0	1	0	0
INHBE	83729	broad.mit.edu	37	12	57849552	57849552	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr12:57849552G>A	ENST00000266646.2	+	1	449	c.233G>A	c.(232-234)aGa>aAa	p.R78K	INHBE_ENST00000551553.1_Intron	NM_031479.3	NP_113667.1	P58166	INHBE_HUMAN	inhibin, beta E	78					growth	extracellular region	growth factor activity|hormone activity			breast(2)|central_nervous_system(1)|large_intestine(2)|lung(7)|prostate(1)|skin(2)	15						GCCCTCCGGAGACTACAGCCA	0.587000											OREG0021944	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	16					0	0	1	0	0
HIST1H1A	3024	broad.mit.edu	37	6	26017778	26017778	+	Silent	SNP	C	C	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr6:26017778C>A	ENST00000244573.3	-	1	262	c.183G>T	c.(181-183)tcG>tcT	p.S61S		NM_005325.3	NP_005316.1	Q02539	H11_HUMAN	histone cluster 1, H1a	61	H15.				nucleosome assembly|spermatogenesis	nucleosome|nucleus	DNA binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|ovary(3)|prostate(1)	13						GAGCTGCCAACGACACACCAC	0.572000													7	67					8.12818e-05	8.61868e-05	1	1	0
ABCA8	10351	broad.mit.edu	37	17	66864298	66864298	+	Silent	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr17:66864298C>T	ENST00000269080.2	-	38	4811	c.4674G>A	c.(4672-4674)caG>caA	p.Q1558Q	ABCA8_ENST00000586539.1_Silent_p.Q1598Q|ABCA8_ENST00000430352.2_Silent_p.Q1598Q	NM_007168.2	NP_009099.1	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	1558						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					CACCCAGCTCCTGCTCCTTGG	0.488000													6	13					0	0	1	0	0
EFCAB6	64800	broad.mit.edu	37	22	43976449	43976449	+	Silent	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr22:43976449C>T	ENST00000262726.7	-	25	3376	c.3123G>A	c.(3121-3123)aaG>aaA	p.K1041K	EFCAB6_ENST00000396231.2_Silent_p.K889K	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	1041					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				CTTCTTTTTCCTTGGGCTGAG	0.498000													13	130					0	0	1	0	0
GBP4	115361	broad.mit.edu	37	1	89655859	89655859	+	Missense_Mutation	SNP	C	C	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr1:89655859C>A	ENST00000355754.6	-	7	1156	c.1059G>T	c.(1057-1059)atG>atT	p.M353I		NM_052941.4	NP_443173.2	Q96PP9	GBP4_HUMAN	guanylate binding protein 4	353						cytoplasm	GTP binding|GTPase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(19)|skin(1)|stomach(2)|urinary_tract(1)	33				all cancers(265;0.00723)|Epithelial(280;0.0291)		GTTGCTGGGCCATCTGCTGGC	0.602000													5	36					0.000602214	0.000629065	1	1	0
PLIN4	729359	broad.mit.edu	37	19	4510722	4510722	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr19:4510722G>A	ENST00000301286.3	-	3	3207	c.3208C>T	c.(3208-3210)Ccc>Tcc	p.P1070S		NM_001080400.1	NP_001073869.1	Q96Q06	PLIN4_HUMAN	perilipin 4	1070						lipid particle|plasma membrane				NS(2)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|soft_tissue(1)|stomach(2)	41						GCCTCTTGGGGGCTCAGGGCA	0.647000													7	14					0	0	1	0	0
ZDHHC8P1	150244	broad.mit.edu	37	22	23742462	23742462	+	RNA	SNP	A	A	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr22:23742462A>T	ENST00000255890.4	-	0	747																											ACATTATTGTAGGACAGGCTG	0.657000													21	12					0	0	1	0	0
PCDH10	57575	broad.mit.edu	37	4	134073854	134073854	+	Silent	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr4:134073854C>T	ENST00000264360.5	+	1	3385	c.2559C>T	c.(2557-2559)tgC>tgT	p.C853C		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10						homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		ACAACCCCTGCGGGGCCATCG	0.572000													5	33					0	0	1	0	0
HIST1H1C	3006	broad.mit.edu	37	6	26056192	26056192	+	Silent	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr6:26056192C>T	ENST00000343677.2	-	1	507	c.465G>A	c.(463-465)ccG>ccA	p.P155P		NM_005319.3	NP_005310.1	P16403	H12_HUMAN	histone cluster 1, H1c	155					nucleosome assembly	nucleosome|nucleus	DNA binding	p.P155P(1)		NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(1)|large_intestine(1)|lung(8)|ovary(4)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)	34						TCGCTTTCTTCGGTGTTTTCT	0.572000													60	25					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179595381	179595381	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr2:179595381G>A	ENST00000589042.1	-	61	18103	c.17879C>T	c.(17878-17880)tCa>tTa	p.S5960L	TTN_ENST00000591111.1_Missense_Mutation_p.S5643L|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.S4716L	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5643	Ig-like 40.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCACTAGCTGATATTTCTTG	0.403000													24	35					0	0	1	0	0
STAG2	10735	broad.mit.edu	37	X	123197011	123197011	+	Nonsense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chrX:123197011C>T	ENST00000371160.1	+	19	2067	c.1777C>T	c.(1777-1779)Cag>Tag	p.Q593*	STAG2_ENST00000371157.3_Nonsense_Mutation_p.Q593*|STAG2_ENST00000469481.1_Intron|STAG2_ENST00000371144.3_Nonsense_Mutation_p.Q593*|STAG2_ENST00000354548.5_Nonsense_Mutation_p.Q524*|STAG2_ENST00000371145.3_Nonsense_Mutation_p.Q593*|STAG2_ENST00000218089.9_Nonsense_Mutation_p.Q593*	NM_001282418.1	NP_001269347.1	Q8N3U4	STAG2_HUMAN	stromal antigen 2	593					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(9)|lung(21)|ovary(5)|prostate(2)|skin(5)|urinary_tract(4)	78						GCAGTTGCCTCAGTACTTTGA	0.279000													9	4					0	0	1	0	0
C12orf50	160419	broad.mit.edu	37	12	88380096	88380096	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr12:88380096C>T	ENST00000298699.2	-	10	1095	c.915G>A	c.(913-915)atG>atA	p.M305I	C12orf50_ENST00000550553.1_Missense_Mutation_p.M266I	NM_152589.1	NP_689802.1	Q8NA57	CL050_HUMAN	chromosome 12 open reading frame 50	305										NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|skin(3)|urinary_tract(2)	34						TACCTCTCTGCATTCCAGAGT	0.308000													4	20					0	0	1	0	0
TAF6	6878	broad.mit.edu	37	7	99709785	99709785	+	Silent	SNP	G	G	C			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr7:99709785G>C	ENST00000344095.4	-	7	1191	c.666C>G	c.(664-666)ctC>ctG	p.L222L	TAF6_ENST00000453269.2_Silent_p.L222L|TAF6_ENST00000418432.2_Silent_p.L146L|TAF6_ENST00000472509.1_Silent_p.L279L|TAF6_ENST00000437822.2_Silent_p.L259L|TAF6_ENST00000452041.1_Silent_p.L222L	NM_005641.3	NP_005632.1	P49848	TAF6_HUMAN	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa	222					negative regulation of cell cycle|negative regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|urinary_tract(2)	26	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CCTTGTAGTAGAGCTGCTGCT	0.657000													17	9					0	0	1	0	0
COL4A2	1284	broad.mit.edu	37	13	111156572	111156572	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr13:111156572G>A	ENST00000360467.5	+	45	4669	c.4363G>A	c.(4363-4365)Gaa>Aaa	p.E1455K	COL4A2-AS1_ENST00000417970.2_RNA	NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	1455	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			CCGGGGAGATGAAGGACCCAT	0.597000													17	58					0	0	1	0	0
GTPBP3	84705	broad.mit.edu	37	19	17449795	17449795	+	Silent	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr19:17449795C>T	ENST00000324894.8	+	5	692	c.624C>T	c.(622-624)ttC>ttT	p.F208F	GTPBP3_ENST00000361619.5_Silent_p.F230F|GTPBP3_ENST00000598038.1_3'UTR|GTPBP3_ENST00000600625.1_Silent_p.F208F|GTPBP3_ENST00000358792.7_Silent_p.F208F	NM_032620.3|NM_133644.3	NP_116009.2|NP_598399.2	Q969Y2	GTPB3_HUMAN	GTP binding protein 3 (mitochondrial)	208					tRNA modification	mitochondrion	GTP binding|GTPase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(7)|skin(2)|upper_aerodigestive_tract(1)	18						ATATCGATTTCGGCGAGGATG	0.612000													8	37					0	0	1	0	0
SLC14A1	6563	broad.mit.edu	37	18	43329783	43329783	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr18:43329783C>T	ENST00000321925.4	+	10	1269	c.1037C>T	c.(1036-1038)aCg>aTg	p.T346M	SLC14A1_ENST00000415427.3_Missense_Mutation_p.T402M|SLC14A1_ENST00000402943.2_Missense_Mutation_p.T241M|SLC14A1_ENST00000591541.1_Missense_Mutation_p.T50M|SLC14A1_ENST00000589700.1_Missense_Mutation_p.R297C|SLC14A1_ENST00000586142.1_Missense_Mutation_p.T346M|SLC14A1_ENST00000535474.1_Missense_Mutation_p.T214M|SLC14A1_ENST00000436407.3_Missense_Mutation_p.T402M|SLC14A1_ENST00000502059.2_Missense_Mutation_p.T238M	NM_001128588.3|NM_001146036.2|NM_015865.6	NP_001122060.3|NP_001139508.2|NP_056949.4	Q13336	UT1_HUMAN	solute carrier family 14 (urea transporter), member 1	346						integral to plasma membrane	urea transmembrane transporter activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(11)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	21						TGTTTGGCCACGCTATTGTTC	0.478000													5	32					0	0	1	0	0
ATP13A4	84239	broad.mit.edu	37	3	193151664	193151664	+	Silent	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr3:193151664G>A	ENST00000342695.4	-	25	3134	c.2812C>T	c.(2812-2814)Ctg>Ttg	p.L938L	ATP13A4_ENST00000392443.3_Silent_p.L919L	NM_032279.2	NP_115655.2	Q4VNC1	AT134_HUMAN	ATPase type 13A4	938					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(27)|ovary(2)|prostate(3)|skin(11)|upper_aerodigestive_tract(2)	71	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		GTAATGGCCAGATCCTGGAAC	0.388000													33	27					0	0	1	0	0
POLR3A	11128	broad.mit.edu	37	10	79781643	79781643	+	Silent	SNP	G	G	A			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr10:79781643G>A	ENST00000372371.3	-	7	1160	c.1023C>T	c.(1021-1023)ttC>ttT	p.F341F		NM_007055.3	NP_008986.2	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide A, 155kDa	341					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding			breast(1)|endometrium(7)|kidney(3)|large_intestine(13)|lung(25)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	59	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			GGCGTTGGACGAAGCCTCTGG	0.537000													3	19					0	0	1	0	0
SMIM7	79086	broad.mit.edu	37	19	16770914	16770914	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr19:16770914C>T	ENST00000487416.2	-	1	54	c.8G>A	c.(7-9)gGa>gAa	p.G3E	CTC-429P9.4_ENST00000593962.1_5'UTR|SMIM7_ENST00000597711.1_Missense_Mutation_p.G3E|CTC-429P9.4_ENST00000600705.1_Missense_Mutation_p.G3E|SMIM7_ENST00000358726.6_Missense_Mutation_p.G3E	NM_024104.3	NP_077009.2			small integral membrane protein 7									p.G3E(1)									CAGGATGTCTCCGATCATCGT	0.607000													5	21					0	0	1	0	0
PPIG	9360	broad.mit.edu	37	2	170465233	170465234	+	Frame_Shift_Ins	INS	-	-	AG			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr2:170465233_170465234insAG	ENST00000260970.3	+	7	562_563	c.342_343insAG	c.(343-345)agafs	p.R115fs	PPIG_ENST00000462903.1_Frame_Shift_Ins_p.R115fs|PPIG_ENST00000448752.2_Frame_Shift_Ins_p.R115fs|PPIG_ENST00000409714.3_Frame_Shift_Ins_p.R100fs	NM_004792.2	NP_004783.2	Q13427	PPIG_HUMAN	peptidylprolyl isomerase G (cyclophilin G)	115	PPIase cyclophilin-type.				protein folding|RNA splicing	nuclear matrix|nuclear speck	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(17)|ovary(2)|stomach(1)|urinary_tract(1)	43					L-Proline(DB00172)	CAATGGCCAACAGAGGGAAGGA	0.376													14	29	---	---	---	---					
ZSCAN31	64288	broad.mit.edu	37	6	28293956	28293956	+	Frame_Shift_Del	DEL	C	C	-			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr6:28293956delC	ENST00000414429.1	-	8	2111	c.1208delG	c.(1207-1209)ggafs	p.G403fs	ZSCAN31_ENST00000396838.2_Frame_Shift_Del_p.G403fs|ZSCAN31_ENST00000439158.1_Frame_Shift_Del_p.G403fs|ZSCAN31_ENST00000481934.1_5'UTR|ZSCAN31_ENST00000344279.6_Frame_Shift_Del_p.G403fs|ZSCAN31_ENST00000446474.1_Frame_Shift_Del_p.G244fs					zinc finger and SCAN domain containing 31																		TGGTCTCTCTCCAGTGTGGAT	0.438													37	318	---	---	---	---					
ASAP1	50807	broad.mit.edu	37	8	131193031	131193031	+	Frame_Shift_Del	DEL	T	T	-			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr8:131193031delT	ENST00000357668.1	-	7	653	c.626delA	c.(625-627)aagfs	p.K209fs	ASAP1_ENST00000518721.1_Frame_Shift_Del_p.K209fs			Q9ULH1	ASAP1_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	209					cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(22)|ovary(6)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	68						GCGCCTTTCCTTCTCCATTTC	0.418													9	99	---	---	---	---					
FAM181B	220382	broad.mit.edu	37	11	82444116	82444116	+	Frame_Shift_Del	DEL	T	T	-			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr11:82444116delT	ENST00000329203.3	-	1	790	c.656delA	c.(655-657)aagfs	p.K219fs		NM_175885.3	NP_787081.2	A6NEQ2	F181B_HUMAN	family with sequence similarity 181, member B	219	Gly-rich.									large_intestine(1)|lung(2)|prostate(1)	4						CAGCGGGACCTTCCTGGCCCC	0.781													2	4	---	---	---	---					
RCOR1	23186	broad.mit.edu	37	14	103059442	103059444	+	In_Frame_Del	DEL	GGC	GGC	-			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr14:103059442_103059444delGGC	ENST00000262241.6	+	1	445_447	c.219_221delGGC	c.(217-222)ttggcg>ttg	p.A77del	RCOR1_ENST00000570597.1_In_Frame_Del_p.A74del	NM_015156.3	NP_055971.2	Q9UKL0	RCOR1_HUMAN	REST corepressor 1	74	Interaction with HDAC1.				blood coagulation|histone H4 deacetylation|interspecies interaction between organisms	transcriptional repressor complex	protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription regulatory region DNA binding			NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	12						ATAAAAGTTTGGCGGCGGCGGCG	0.729													2	4	---	---	---	---					
SLC35G6	643664	broad.mit.edu	37	17	7385757	7385766	+	Frame_Shift_Del	DEL	CAGGGTCTCA	CAGGGTCTCA	-			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr17:7385757_7385766delCAGGGTCTCA	ENST00000412468.2	+	2	569_578	c.454_463delCAGGGTCTCA	c.(454-465)cagggtctcagtfs	p.QGLS152fs	ZBTB4_ENST00000311403.4_Intron	NM_001102614.1	NP_001096084.1	P0C7Q6	AMCL3_HUMAN	solute carrier family 35, member G6	152	DUF6 1.					integral to membrane											CCTTGAGAGCCAGGGTCTCAGTGGCTACGA	0.590													75	66	---	---	---	---					
SLC16A8	23539	broad.mit.edu	37	22	38477211	38477211	+	Frame_Shift_Del	DEL	G	G	-			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chr22:38477211delG	ENST00000320521.5	-	4	942	c.834delC	c.(832-834)gccfs	p.A278fs	SLC16A8_ENST00000469516.1_Intron	NM_013356.2	NP_037488.2	O95907	MOT3_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 8	278					blood coagulation|leukocyte migration|pyruvate metabolic process	integral to plasma membrane|membrane fraction	lactate transmembrane transporter activity|secondary active monocarboxylate transmembrane transporter activity|symporter activity			kidney(1)|large_intestine(1)|prostate(1)	3	Melanoma(58;0.045)				Pyruvic acid(DB00119)	CCGCGTCCTTGGCGTAGTTCA	0.711													2	4	---	---	---	---					
REPS2	9185	broad.mit.edu	37	X	17043290	17043300	+	Frame_Shift_Del	DEL	GCAGAACAGAT	GCAGAACAGAT	-			TCGA-E7-A4IJ-01A-31D-A26M-08	TCGA-E7-A4IJ-10A-01D-A26K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50e46ae7-68b2-48b2-b3ae-0481677c53a6	673721c5-3509-488a-8f5d-c801bd1f1568	g.chrX:17043290_17043300delGCAGAACAGAT	ENST00000357277.3	+	4	826_836	c.655_665delGCAGAACAGAT	c.(655-666)gcagaacagatgfs	p.AEQM219fs	REPS2_ENST00000380064.4_Frame_Shift_Del_p.AEQM79fs|REPS2_ENST00000303843.7_Frame_Shift_Del_p.AEQM218fs	NM_001080975.1|NM_004726.2	NP_001074444.1|NP_004717.2	Q8NFH8	REPS2_HUMAN	RALBP1 associated Eps domain containing 2	219					epidermal growth factor receptor signaling pathway|protein complex assembly	cytoplasm	calcium ion binding|protein binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|ovary(2)|skin(3)|urinary_tract(1)	17	Hepatocellular(33;0.183)					GCGGAGCAGCGCAGAACAGATGCATCCAGGT	0.573													15	39	---	---	---	---