Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
STRN	6801	broad.mit.edu	37	2	37121047	37121047	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:37121047C>T	ENST00000263918.4	-	7	933	c.925G>A	c.(925-927)Gac>Aac	p.D309N	STRN_ENST00000379213.2_Missense_Mutation_p.D297N	NM_003162.3	NP_003153.2	O43815	STRN_HUMAN	striatin, calmodulin binding protein	309					dendrite development|locomotory behavior|negative regulation of cell proliferation|tight junction assembly|Wnt receptor signaling pathway	cytoplasm|dendritic spine|neuronal cell body|postsynaptic density|postsynaptic membrane|tight junction	armadillo repeat domain binding|calmodulin binding|estrogen receptor binding|protein complex binding|protein phosphatase 2A binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(16)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	33		Ovarian(717;0.0129)|all_hematologic(82;0.21)				TTACCCCAGTCTGTTCCATCG	0.388000													29	104					0	0	1	0	0
NKAPL	222698	broad.mit.edu	37	6	28227237	28227237	+	Missense_Mutation	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:28227237C>A	ENST00000343684.3	+	1	140	c.88C>A	c.(88-90)Ccg>Acg	p.P30T		NM_001007531.1	NP_001007532.1	Q5M9Q1	NKAPL_HUMAN	NFKB activating protein-like	30										breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	31						CCCACCATCCCCGCAGAGCAG	0.662000													18	47					5.3912e-06	5.5524e-06	1	1	0
RAB42	115273	broad.mit.edu	37	1	28920610	28920610	+	Nonsense_Mutation	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:28920610C>A	ENST00000373826.3	+	2	605	c.299C>A	c.(298-300)tCa>tAa	p.S100*	TAF12_ENST00000471683.1_Intron|RAB42_ENST00000465518.1_3'UTR	NM_152304.1	NP_689517.1	Q8N4Z0	RAB42_HUMAN	RAB42, member RAS oncogene family	100					small GTPase mediated signal transduction	membrane	GTP binding			breast(1)|endometrium(1)|large_intestine(1)|lung(2)	5		Colorectal(325;0.000147)|Renal(390;0.00357)|Lung NSC(340;0.00618)|all_lung(284;0.00909)|Breast(348;0.0249)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0577)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00298)|KIRC - Kidney renal clear cell carcinoma(1967;0.00948)|BRCA - Breast invasive adenocarcinoma(304;0.0213)|READ - Rectum adenocarcinoma(331;0.0649)		AAGCAGCACTCAGGCCCATGC	0.592000													9	32					1.08611e-07	1.13876e-07	1	1	0
GRWD1	83743	broad.mit.edu	37	19	48956281	48956281	+	Nonstop_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:48956281G>C	ENST00000253237.5	+	7	1573	c.1340G>C	c.(1339-1341)tGa>tCa	p.*447S		NM_031485.3	NP_113673.3	Q9BQ67	GRWD1_HUMAN	glutamate-rich WD repeat containing 1	0						nucleolus				endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|stomach(1)	19		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000206)|all cancers(93;0.000207)|Epithelial(262;0.0125)|GBM - Glioblastoma multiforme(486;0.0222)		ATCAGCGTCTGAGGCGTCCCA	0.602000													18	62					0	0	1	0	0
IFT46	56912	broad.mit.edu	37	11	118428457	118428457	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:118428457C>G	ENST00000264020.2	-	4	571	c.194G>C	c.(193-195)aGa>aCa	p.R65T	IFT46_ENST00000264021.3_Intron|IFT46_ENST00000530872.1_Missense_Mutation_p.R65T	NM_020153.3	NP_064538.3	Q9NQC8	IFT46_HUMAN	intraflagellar transport 46 homolog (Chlamydomonas)	15					flagellum assembly|intraflagellar transport|protein stabilization	microtubule basal body|microtubule-based flagellum|nucleus	protein C-terminus binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)	9						ACCTACCTTTCTGTGCTTCTG	0.453000													75	15					0	0	1	0	0
C9orf40	55071	broad.mit.edu	37	9	77567322	77567322	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr9:77567322G>A	ENST00000376854.5	-	1	480	c.206C>T	c.(205-207)tCg>tTg	p.S69L		NM_017998.2	NP_060468.2	Q8IXQ3	CI040_HUMAN	chromosome 9 open reading frame 40	69										lung(2)|stomach(1)	3						CTTGCTGGGCGAAGCCGAGGG	0.726000													4	0					0	0	1	0	0
AES	166	broad.mit.edu	37	19	3061215	3061215	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:3061215G>C	ENST00000221561.8	-	2	448	c.269C>G	c.(268-270)tCg>tGg	p.S90W	AES_ENST00000586839.1_5'UTR|AES_ENST00000592330.1_5'UTR|AES_ENST00000327141.4_Missense_Mutation_p.S23W	NM_198969.1	NP_945320.1	Q08117	AES_HUMAN	amino-terminal enhancer of split	23	Gln-rich (Q domain).				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of response to cytokine stimulus|negative regulation of transcription from RNA polymerase II promoter|organ morphogenesis|response to interleukin-1|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity			lung(8)	8		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCAGGAGTCCGAGGTGGTGAA	0.642000													12	211					0	0	1	0	0
C2orf78	388960	broad.mit.edu	37	2	74040782	74040782	+	Silent	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:74040782C>G	ENST00000409561.1	+	2	397	c.276C>G	c.(274-276)ctC>ctG	p.L92L		NM_001080474.1	NP_001073943.1	A6NCI8	CB078_HUMAN	chromosome 2 open reading frame 78	92	Ser-rich.									cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|soft_tissue(1)|urinary_tract(1)	34						TCCAGCCACTCATGGGCAGTG	0.532000													14	55					0	0	1	0	0
CALD1	800	broad.mit.edu	37	7	134618796	134618796	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:134618796G>C	ENST00000361675.2	+	5	1505	c.1276G>C	c.(1276-1278)Gat>Cat	p.D426H	CALD1_ENST00000361388.2_Intron|CALD1_ENST00000361901.2_Intron|CALD1_ENST00000424922.1_Intron|CALD1_ENST00000393118.2_Intron|CALD1_ENST00000422748.1_Intron|CALD1_ENST00000417172.1_Intron|CALD1_ENST00000543443.1_Intron|CALD1_ENST00000495522.1_Intron			Q05682	CALD1_HUMAN	caldesmon 1	426					cellular component movement|muscle contraction	cytosol|focal adhesion|myofibril	actin binding|calmodulin binding|myosin binding|tropomyosin binding			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(15)|lung(10)	43						AGCACAAGAAGATAAACTTCA	0.368000													4	97					0	0	1	0	0
TRIO	7204	broad.mit.edu	37	5	14389481	14389481	+	Missense_Mutation	SNP	G	G	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:14389481G>T	ENST00000344204.4	+	25	4056	c.4032G>T	c.(4030-4032)atG>atT	p.M1344I	TRIO_ENST00000537187.1_Missense_Mutation_p.M1344I|TRIO_ENST00000509967.2_Missense_Mutation_p.M1295I	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	1344	DH 1.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					TCGGAAACATGCAAGAAATCT	0.428000													4	66					0.00909568	0.00913497	1	1	0
ACACB	32	broad.mit.edu	37	12	109629436	109629436	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:109629436G>C	ENST00000338432.7	+	14	2282	c.2163G>C	c.(2161-2163)ttG>ttC	p.L721F	ACACB_ENST00000377854.5_Missense_Mutation_p.L721F|ACACB_ENST00000377848.3_Missense_Mutation_p.L721F			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	721	Biotin carboxylation.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	TGGTGGCTTTGAAGGAACTGT	0.478000													24	63					0	0	1	0	0
TBCB	1155	broad.mit.edu	37	19	36606495	36606495	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:36606495G>A	ENST00000221855.3	+	1	608	c.33G>A	c.(31-33)gtG>gtA	p.V11V	TBCB_ENST00000589996.1_Silent_p.V11V|TBCB_ENST00000392178.4_3'UTR	NM_001281.2	NP_001272.2	Q99426	TBCB_HUMAN	tubulin folding cofactor B	11					'de novo' posttranslational protein folding|cell differentiation|nervous system development	cytoplasm|microtubule	protein binding			large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	5	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			CACCCACGGTGACCGTTTTCA	0.687000													16	12					0	0	1	0	0
UTY	7404	broad.mit.edu	37	Y	15467873	15467873	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chrY:15467873C>G	ENST00000331397.4	-	14	2311	c.1304G>C	c.(1303-1305)aGa>aCa	p.R435T	UTY_ENST00000382896.4_Missense_Mutation_p.R480T|UTY_ENST00000538878.1_Missense_Mutation_p.R402T|UTY_ENST00000540140.1_Missense_Mutation_p.R432T|UTY_ENST00000362096.4_Missense_Mutation_p.R435T|UTY_ENST00000329134.5_Missense_Mutation_p.R435T|UTY_ENST00000537580.1_Missense_Mutation_p.R480T|UTY_ENST00000545955.1_Missense_Mutation_p.R510T	NM_001258267.1|NM_007125.4	NP_001245196.1|NP_009056.3	O14607	UTY_HUMAN	ubiquitously transcribed tetratricopeptide repeat containing, Y-linked	435					chromatin modification	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(1)|lung(6)	7						TAAATTATCTCTATTTGCTCG	0.299000													14	2					0	0	1	0	0
FAM49A	81553	broad.mit.edu	37	2	16742492	16742492	+	Missense_Mutation	SNP	G	G	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:16742492G>T	ENST00000381323.3	-	8	787	c.567C>A	c.(565-567)ttC>ttA	p.F189L	FAM49A_ENST00000406434.1_Missense_Mutation_p.F189L|FAM49A_ENST00000355549.2_Missense_Mutation_p.F189L	NM_030797.3	NP_110424.1	Q9H0Q0	FA49A_HUMAN	family with sequence similarity 49, member A	189						intracellular				breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(172;0.0734)|all_hematologic(175;0.088)		GBM - Glioblastoma multiforme(3;0.00969)			CTTCTGCATAGAAGAGGGACA	0.398000													50	40					1.35964e-18	1.46012e-18	1	1	0
FAT4	79633	broad.mit.edu	37	4	126241768	126241768	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:126241768C>T	ENST00000394329.3	+	1	4215	c.4202C>T	c.(4201-4203)tCa>tTa	p.S1401L		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1401	Cadherin 13.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CCTCCTCGTTCATCTACAATG	0.378000													11	204					0	0	1	0	0
KCNN4	3783	broad.mit.edu	37	19	44271757	44271757	+	Nonsense_Mutation	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:44271757C>A	ENST00000262888.3	-	8	1617	c.1222G>T	c.(1222-1224)Gag>Tag	p.E408*		NM_002250.2	NP_002241.1	O15554	KCNN4_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	408					defense response	voltage-gated potassium channel complex	calcium-activated potassium channel activity|calmodulin binding			biliary_tract(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	15		Prostate(69;0.0352)			Clotrimazole(DB00257)|Halothane(DB01159)|Quinine(DB00468)	CTAAGCAGCTCAGTCAGGGCA	0.612000													10	64					2.74318e-10	2.89904e-10	1	1	0
IFT81	28981	broad.mit.edu	37	12	110600732	110600732	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:110600732C>G	ENST00000242591.5	+	11	1556	c.1050C>G	c.(1048-1050)atC>atG	p.I350M	IFT81_ENST00000361948.4_Missense_Mutation_p.I350M|IFT81_ENST00000549009.1_3'UTR|IFT81_ENST00000552912.1_Missense_Mutation_p.I350M	NM_014055.3	NP_054774.2	Q8WYA0	IFT81_HUMAN	intraflagellar transport 81 homolog (Chlamydomonas)	350					cell differentiation|multicellular organismal development|spermatogenesis	intraflagellar transport particle B|microtubule-based flagellum				endometrium(1)|large_intestine(2)|lung(5)|ovary(1)|stomach(1)	10						AGGCATCTATCATTTCCCGTA	0.353000													30	22					0	0	1	0	0
ATF4	468	broad.mit.edu	37	22	39918445	39918445	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr22:39918445G>A	ENST00000337304.2	+	2	1776	c.894G>A	c.(892-894)aaG>aaA	p.K298K	ATF4_ENST00000404241.2_Silent_p.K298K|ATF4_ENST00000396680.1_Silent_p.K298K	NM_001675.2	NP_001666.2	P18848	ATF4_HUMAN	activating transcription factor 4	298					cellular amino acid metabolic process|gluconeogenesis|positive regulation of transcription from RNA polymerase II promoter|response to endoplasmic reticulum stress|transcription from RNA polymerase II promoter	cytoplasm|plasma membrane	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|large_intestine(2)|lung(5)|skin(1)	11	Melanoma(58;0.04)					ACCGCCAGAAGAAGAGGGCGG	0.498000													4	14					0	0	1	0	0
KRBA1	84626	broad.mit.edu	37	7	149420826	149420826	+	Splice_Site	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:149420826G>A	ENST00000255992.10	+	8	1173	c.774G>A	c.(772-774)gtG>gtA	p.V258V	KRBA1_ENST00000319551.8_Splice_Site_p.V258V|KRBA1_ENST00000485033.2_Splice_Site_p.V258V|KRBA1_ENST00000479560.1_3'UTR	NM_032534.2	NP_115923.2	A5PL33	KRBA1_HUMAN	KRAB-A domain containing 1	258										breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(17)|ovary(1)|prostate(1)	27	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TTTCCTTAGTGAAGACCGAGG	0.557000													19	7					0	0	1	0	0
DPH1	1801	broad.mit.edu	37	17	1943809	1943809	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:1943809C>T	ENST00000263083.6	+	9	977	c.932C>T	c.(931-933)tCt>tTt	p.S311F	DPH1_ENST00000570477.1_Missense_Mutation_p.S231F	NM_001383.3	NP_001374.3	Q9BZG8	DPH1_HUMAN	diphthamide biosynthesis 1	311					peptidyl-diphthamide biosynthetic process from peptidyl-histidine|translation	cytoplasm|nucleus				endometrium(3)|large_intestine(2)|lung(6)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	17						CACCTGGAATCTCGACTCCGA	0.567000													55	10					0	0	1	0	0
SLC6A6	6533	broad.mit.edu	37	3	14485245	14485245	+	Nonsense_Mutation	SNP	G	G	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:14485245G>T	ENST00000454876.2	+	3	432	c.103G>T	c.(103-105)Gag>Tag	p.E35*	SLC6A6_ENST00000484191.1_Intron|SLC6A6_ENST00000416216.2_Nonsense_Mutation_p.E35*|SLC6A6_ENST00000360861.3_Nonsense_Mutation_p.E35*			P31641	SC6A6_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 6	35					cellular amino acid metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity|taurine:sodium symporter activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|skin(2)	28						GGACGAGGCTGAGGGAAAACC	0.602000													47	74					3.21987e-24	3.48195e-24	1	1	0
ADRB1	153	broad.mit.edu	37	10	115804639	115804639	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr10:115804639G>A	ENST00000369295.2	+	1	834	c.748G>A	c.(748-750)Gag>Aag	p.E250K		NM_000684.2	NP_000675.1	P08588	ADRB1_HUMAN	adrenoceptor beta 1	250					positive regulation of cAMP biosynthetic process	integral to plasma membrane	alpha-2A adrenergic receptor binding|beta1-adrenergic receptor activity|protein heterodimerization activity			large_intestine(4)|lung(1)|upper_aerodigestive_tract(1)	6		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0124)|all cancers(201;0.0298)	Acebutolol(DB01193)|Alprenolol(DB00866)|Amiodarone(DB01118)|Arbutamine(DB01102)|Atenolol(DB00335)|Betaxolol(DB00195)|Bevantolol(DB01295)|Bisoprolol(DB00612)|Bretylium(DB01158)|Carteolol(DB00521)|Carvedilol(DB01136)|Desipramine(DB01151)|Dobutamine(DB00841)|Dopamine(DB00988)|Epinephrine(DB00668)|Esmolol(DB00187)|Isoetharine(DB00221)|Isoproterenol(DB01064)|Labetalol(DB00598)|Levobunolol(DB01210)|Metipranolol(DB01214)|Metoprolol(DB00264)|Nadolol(DB01203)|Norepinephrine(DB00368)|Oxprenolol(DB01580)|Penbutolol(DB01359)|Pindolol(DB00960)|Practolol(DB01297)|Propranolol(DB00571)|Risperidone(DB00734)|Timolol(DB00373)|Ziprasidone(DB00246)	GGTGTTCCGCGAGGCCCAGAA	0.692000													6	49					0	0	1	0	0
UBAP2L	9898	broad.mit.edu	37	1	154228167	154228167	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:154228167C>G	ENST00000428931.1	+	18	2260	c.2093C>G	c.(2092-2094)tCt>tGt	p.S698C	UBAP2L_ENST00000271877.7_Missense_Mutation_p.S709C|UBAP2L_ENST00000361546.2_Missense_Mutation_p.S698C|UBAP2L_ENST00000343815.6_Missense_Mutation_p.S698C	NM_014847.3	NP_055662.3	Q14157	UBP2L_HUMAN	ubiquitin associated protein 2-like	698					binding of sperm to zona pellucida		protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(20)|ovary(1)|prostate(1)|urinary_tract(2)	50	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			AGCACGTTATCTACGCAGCAG	0.438000													10	109					0	0	1	0	0
SPA17	53340	broad.mit.edu	37	11	124564208	124564208	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:124564208G>A	ENST00000532692.1	+	4	1743	c.322G>A	c.(322-324)Gag>Aag	p.E108K	SPA17_ENST00000227135.2_Missense_Mutation_p.E108K|SIAE_ENST00000525730.1_5'UTR|SPA17_ENST00000524614.1_3'UTR			Q15506	SP17_HUMAN	sperm autoantigenic protein 17	108					binding of sperm to zona pellucida|ciliary or flagellar motility|signal transduction|spermatogenesis	cytoplasm|flagellum|membrane|motile cilium|primary cilium	cAMP-dependent protein kinase regulator activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)	5	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0223)		GGACTCTTCTGAGGAAGATAA	0.378000													4	93					0	0	1	0	0
ATF4	468	broad.mit.edu	37	22	39918557	39918557	+	Missense_Mutation	SNP	G	G	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr22:39918557G>T	ENST00000337304.2	+	2	1888	c.1006G>T	c.(1006-1008)Gat>Tat	p.D336Y	ATF4_ENST00000404241.2_Missense_Mutation_p.D336Y|ATF4_ENST00000396680.1_Missense_Mutation_p.D336Y	NM_001675.2	NP_001666.2	P18848	ATF4_HUMAN	activating transcription factor 4	336	Interaction with GABBR1 (By similarity).				cellular amino acid metabolic process|gluconeogenesis|positive regulation of transcription from RNA polymerase II promoter|response to endoplasmic reticulum stress|transcription from RNA polymerase II promoter	cytoplasm|plasma membrane	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|large_intestine(2)|lung(5)|skin(1)	11	Melanoma(58;0.04)					GTACCTGAAAGATTTGATAGA	0.507000													4	21					2.0095e-06	2.07879e-06	1	1	0
PHOSPHO1	162466	broad.mit.edu	37	17	47302319	47302319	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:47302319G>A	ENST00000413580.1	-	3	585	c.168C>T	c.(166-168)ttC>ttT	p.F56F	PHOSPHO1_ENST00000310544.4_Silent_p.F31F|PHOSPHO1_ENST00000514112.1_Silent_p.F56F	NM_001143804.1|NM_178500.3	NP_001137276.1|NP_848595.1	Q8TCT1	PHOP1_HUMAN	phosphatase, orphan 1	31					regulation of bone mineralization		metal ion binding|phosphoethanolamine/phosphocholine phosphatase activity							Epithelial(5;8.1e-06)|all cancers(6;7.71e-05)		Choline(DB00122)	CGTCGAAGTCGAAGGTCAGGA	0.701000													4	1					0	0	1	0	0
TTLL3	26140	broad.mit.edu	37	3	9876587	9876587	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:9876587G>C	ENST00000547186.1	+	12	2135	c.1919G>C	c.(1918-1920)aGa>aCa	p.R640T	TTLL3_ENST00000397241.1_3'UTR|ARPC4-TTLL3_ENST00000397256.1_3'UTR|TTLL3_ENST00000455274.1_Intron|TTLL3_ENST00000426895.4_Missense_Mutation_p.R783T|TTLL3_ENST00000383827.1_3'UTR|TTLL3_ENST00000430793.1_Missense_Mutation_p.R428T	NM_001025930.3	NP_001021100.3	Q9Y4R7	TTLL3_HUMAN	tubulin tyrosine ligase-like family, member 3	640					axoneme assembly|cilium assembly|protein polyglycylation	cilium axoneme|cytoplasm|microtubule	protein-glycine ligase activity, initiating|tubulin-tyrosine ligase activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(2)|skin(1)	26	Medulloblastoma(99;0.227)					CTGAAGCCAAGAAAGGTGGGC	0.612000													30	39					0	0	1	0	0
SMARCE1	6605	broad.mit.edu	37	17	38785138	38785138	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:38785138C>G	ENST00000348513.6	-	11	1915	c.1135G>C	c.(1135-1137)Gag>Cag	p.E379Q	KRT222_ENST00000476049.1_3'UTR|SMARCE1_ENST00000580419.1_Missense_Mutation_p.E344Q|SMARCE1_ENST00000578044.1_Missense_Mutation_p.E309Q|SMARCE1_ENST00000400122.3_3'UTR|SMARCE1_ENST00000544009.1_Missense_Mutation_p.E309Q|SMARCE1_ENST00000431889.2_Missense_Mutation_p.E361Q|SMARCE1_ENST00000377808.4_3'UTR	NM_003079.4	NP_003070.3	Q969G3	SMCE1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	379	Glu-rich.				chromatin modification|negative regulation of transcription, DNA-dependent|nervous system development|nucleosome disassembly|regulation of transcription from RNA polymerase II promoter	nBAF complex|npBAF complex|nuclear chromosome|SWI/SNF complex|transcriptional repressor complex	chromatin binding|DNA binding|N-acetyltransferase activity|protein binding|protein N-terminus binding|transcription coactivator activity			large_intestine(1)	1		Breast(137;0.000812)				GTTCCTTCCTCTGCCATACTG	0.502000													5	149					0	0	1	0	0
EMP2	2013	broad.mit.edu	37	16	10637430	10637430	+	Nonsense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr16:10637430G>A	ENST00000359543.3	-	3	375	c.166C>T	c.(166-168)Caa>Taa	p.Q56*	EMP2_ENST00000536829.1_Nonsense_Mutation_p.Q56*	NM_001424.4	NP_001415.1	P54851	EMP2_HUMAN	epithelial membrane protein 2	56					cell proliferation	integral to membrane				NS(1)|endometrium(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	6						CACTTACCTTGAAAGCTGTCA	0.493000													6	131					0	0	1	0	0
MRGPRX4	117196	broad.mit.edu	37	11	18195142	18195142	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:18195142G>A	ENST00000314254.3	+	1	759	c.339G>A	c.(337-339)ctG>ctA	p.L113L	RP11-113D6.6_ENST00000527671.1_Intron	NM_054032.3	NP_473373.2	Q96LA9	MRGX4_HUMAN	MAS-related GPR, member X4	113						integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32						TGAGTATGCTGAGCGCCATCA	0.552000													5	123					0	0	1	0	0
C4BPB	725	broad.mit.edu	37	1	207273241	207273241	+	Silent	SNP	G	G	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:207273241G>T	ENST00000243611.5	+	6	1020	c.726G>T	c.(724-726)ctG>ctT	p.L242L	C4BPB_ENST00000391923.1_Silent_p.L242L|C4BPB_ENST00000367076.3_Silent_p.L241L|C4BPB_ENST00000367078.3_Silent_p.L242L|C4BPB_ENST00000470767.1_3'UTR	NM_000716.3	NP_000707.1	P20851	C4BPB_HUMAN	complement component 4 binding protein, beta	242					blood coagulation|complement activation, classical pathway|innate immune response	extracellular region				breast(2)|lung(1)|ovary(1)	4						CTCTGGAGCTGAAGAAAGCTG	0.373000													45	66					3.86236e-30	4.19626e-30	1	1	0
NR2C2	7182	broad.mit.edu	37	3	15071874	15071874	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:15071874G>A	ENST00000425241.1	+	9	1387	c.1025G>A	c.(1024-1026)aGc>aAc	p.S342N	NR2C2_ENST00000323373.6_Missense_Mutation_p.S361N|NR2C2_ENST00000478572.1_3'UTR|NR2C2_ENST00000406272.2_Missense_Mutation_p.S342N|NR2C2_ENST00000393102.3_Missense_Mutation_p.S342N			P49116	NR2C2_HUMAN	nuclear receptor subfamily 2, group C, member 2	342					cell differentiation|nervous system development|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|spermatogenesis	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			breast(1)|endometrium(2)|large_intestine(5)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						GGAGGAGGGAGCATCCACGTC	0.507000													32	142					0	0	1	0	0
QPRT	23475	broad.mit.edu	37	16	29706228	29706228	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr16:29706228G>C	ENST00000395384.4	+	2	418	c.257G>C	c.(256-258)aGa>aCa	p.R86T	QPRT_ENST00000562473.1_Intron|QPRT_ENST00000219771.7_Intron	NM_014298.3	NP_055113.2	Q15274	NADC_HUMAN	quinolinate phosphoribosyltransferase	86					protein oligomerization|quinolinate catabolic process|water-soluble vitamin metabolic process	cytosol	nicotinate-nucleotide diphosphorylase (carboxylating) activity|protein homodimerization activity	p.R86K(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)	9					Niacin(DB00627)	CCGGTGGCCAGAGTGGCCGAG	0.657000													118	64					0	0	1	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33649673	33649673	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:33649673G>A	ENST00000504830.1	-	8	1655	c.1320C>T	c.(1318-1320)atC>atT	p.I440I	ADAMTS12_ENST00000504582.1_5'UTR|ADAMTS12_ENST00000352040.3_Silent_p.I440I	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	440	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						AGAAGCGGGTGATGTACTCCT	0.527000										HNSCC(64;0.19)			77	48					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175054584	175054584	+	Missense_Mutation	SNP	G	G	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:175054584G>T	ENST00000239462.4	+	6	1391	c.1278G>T	c.(1276-1278)atG>atT	p.M426I		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	426	Fibronectin type-III 2.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		TGGTGCCCATGAGAGGAGAGC	0.557000													16	15					1.10513e-12	1.17326e-12	1	1	0
PARP14	54625	broad.mit.edu	37	3	122433111	122433111	+	Nonsense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:122433111C>T	ENST00000474629.2	+	12	4101	c.3835C>T	c.(3835-3837)Cag>Tag	p.Q1279*		NM_017554.2	NP_060024.2	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	1279	Macro 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			NS(2)|breast(5)|cervix(2)|endometrium(7)|kidney(5)|large_intestine(8)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	50				GBM - Glioblastoma multiforme(114;0.0531)		TTTCCCAGCTCAGCAGCGCAA	0.363000													10	8					0	0	1	0	0
CCDC39	339829	broad.mit.edu	37	3	180397136	180397136	+	Nonsense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:180397136C>T	ENST00000273654.4	-	7	904	c.285G>A	c.(283-285)tgG>tgA	p.W95*	CCDC39_ENST00000442201.2_Nonsense_Mutation_p.W11*			Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	11					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				NS(1)|breast(1)|endometrium(4)|large_intestine(9)|lung(22)|ovary(6)|prostate(2)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			ACCCATCCTCCCAGTGCAGCT	0.552000													72	145					0	0	1	0	0
KIN	22944	broad.mit.edu	37	10	7820869	7820869	+	Missense_Mutation	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr10:7820869C>A	ENST00000379562.4	-	5	537	c.490G>T	c.(490-492)Gat>Tat	p.D164Y	KIN_ENST00000535925.1_Missense_Mutation_p.D164Y|KIN_ENST00000543003.1_Missense_Mutation_p.D58Y	NM_012311.3	NP_036443.1	O60870	KIN17_HUMAN	KIN, antigenic determinant of recA protein homolog (mouse)						DNA recombination|DNA repair|DNA replication|interspecies interaction between organisms|mRNA processing	cytoplasm|nuclear matrix	double-stranded DNA binding|RNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|pancreas(1)|skin(2)	19						TCTTCATCATCAAGGTCCTGC	0.463000													5	319					1.23904e-05	1.26766e-05	1	1	0
CHSY3	337876	broad.mit.edu	37	5	129519958	129519958	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:129519958C>T	ENST00000305031.4	+	3	1481	c.1123C>T	c.(1123-1125)Cgg>Tgg	p.R375W	CHSY3_ENST00000507545.1_3'UTR	NM_175856.4	NP_787052.3	Q70JA7	CHSS3_HUMAN	chondroitin sulfate synthase 3	375						Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity	p.R375W(1)		central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|urinary_tract(1)	28		all_cancers(142;0.0227)|Breast(839;0.198)|Prostate(80;0.215)|Lung NSC(810;0.239)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.136)		TGAACACAATCGGAAGGGTTA	0.343000													36	105					0	0	1	0	0
DPY19L2P2	349152	broad.mit.edu	37	7	102912208	102912208	+	RNA	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:102912208C>T	ENST00000312132.4	-	0	2371																											CGTTTTACTGCATTAATTACA	0.333000													4	46					0	0	1	0	0
CHD5	26038	broad.mit.edu	37	1	6184141	6184141	+	Silent	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:6184141C>A	ENST00000262450.3	-	31	4665	c.4566G>T	c.(4564-4566)ggG>ggT	p.G1522G	CHD5_ENST00000378021.1_Silent_p.G379G	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1522					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		TGCTGTACTTCCCGTTGACAT	0.632000													14	32					1.15088e-07	1.2026e-07	1	1	0
NFKB1	4790	broad.mit.edu	37	4	103522086	103522086	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:103522086C>G	ENST00000226574.4	+	16	2139	c.1672C>G	c.(1672-1674)Caa>Gaa	p.Q558E	NFKB1_ENST00000600343.1_Missense_Mutation_p.Q377E|NFKB1_ENST00000505458.1_Missense_Mutation_p.Q557E|NFKB1_ENST00000394820.4_Missense_Mutation_p.Q557E	NM_001165412.1|NM_003998.3	NP_001158884.1|NP_003989.2	P19838	NFKB1_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	557	Interaction with CFLAR.				anti-apoptosis|apoptosis|cellular response to mechanical stimulus|inflammatory response|innate immune response|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of calcidiol 1-monooxygenase activity|nerve growth factor receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter	cytosol|I-kappaB/NF-kappaB complex|mitochondrion|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			biliary_tract(1)|breast(4)|endometrium(2)|large_intestine(6)|lung(7)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	27		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.59e-08)	Dexamethasone(DB01234)|Pranlukast(DB01411)|Thalidomide(DB01041)	CCTTCATTCTCAACTTGTGAG	0.348000													51	59					0	0	1	0	0
IP6K2	51447	broad.mit.edu	37	3	48725748	48725748	+	Silent	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:48725748C>G	ENST00000328631.5	-	6	1462	c.1239G>C	c.(1237-1239)ctG>ctC	p.L413L		NM_001005909.2|NM_016291.3	NP_001005909.1|NP_057375.2	Q9UHH9	IP6K2_HUMAN	inositol hexakisphosphate kinase 2	413					negative regulation of cell growth|phosphatidylinositol phosphorylation|positive regulation of apoptosis|type I interferon-mediated signaling pathway	intermediate filament cytoskeleton|nucleus	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol trisphosphate 3-kinase activity			biliary_tract(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)	15						CAATGTCTATCAGGCTCTGGA	0.562000													4	146					0	0	1	0	0
C3orf20	84077	broad.mit.edu	37	3	14814342	14814342	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:14814342G>A	ENST00000253697.3	+	17	3127	c.2675G>A	c.(2674-2676)aGc>aAc	p.S892N	C3orf20_ENST00000435614.1_Missense_Mutation_p.S770N|C3orf20_ENST00000412910.1_Missense_Mutation_p.S770N	NM_032137.4	NP_115513.4	Q8ND61	CC020_HUMAN	chromosome 3 open reading frame 20	892						cytoplasm|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(13)|lung(11)|ovary(4)|skin(2)	40						AGCAGGGACAGCAAGATAACT	0.587000													4	53					0	0	1	0	0
AVEN	57099	broad.mit.edu	37	15	34163172	34163172	+	Silent	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr15:34163172G>C	ENST00000306730.3	-	4	705	c.576C>G	c.(574-576)ctC>ctG	p.L192L	AVEN_ENST00000558136.1_5'UTR	NM_020371.2	NP_065104.1	Q9NQS1	AVEN_HUMAN	apoptosis, caspase activation inhibitor	192					anti-apoptosis|apoptosis	endomembrane system|intracellular|membrane|membrane fraction	protein binding			cervix(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)|stomach(1)	7		all_lung(180;1.78e-08)		all cancers(64;1.66e-15)|GBM - Glioblastoma multiforme(113;1.42e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0359)		GTCGGAGGCAGAGAGGCAGCT	0.438000													15	40					0	0	1	0	0
ASCC3	10973	broad.mit.edu	37	6	101248283	101248283	+	Nonsense_Mutation	SNP	A	A	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:101248283A>C	ENST00000369162.2	-	6	1364	c.1020T>G	c.(1018-1020)taT>taG	p.Y340*	ASCC3_ENST00000522650.1_Nonsense_Mutation_p.Y340*	NM_006828.2	NP_006819.2	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit 3	340					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(20)|liver(1)|lung(36)|ovary(6)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	92		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		CTTCACGTCGATATTGTTTCA	0.343000													25	25					0	0	1	0	0
INPP1	3628	broad.mit.edu	37	2	191231453	191231453	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:191231453G>C	ENST00000392329.2	+	5	998	c.298G>C	c.(298-300)Gag>Cag	p.E100Q	INPP1_ENST00000417336.1_3'UTR|INPP1_ENST00000541441.1_Missense_Mutation_p.E100Q|INPP1_ENST00000322522.4_Missense_Mutation_p.E100Q	NM_001128928.1	NP_001122400.1	P49441	INPP_HUMAN	inositol polyphosphate-1-phosphatase	100					signal transduction		inositol-1,4-bisphosphate 1-phosphatase activity|metal ion binding			cervix(1)|large_intestine(2)|lung(6)|ovary(1)|urinary_tract(1)	11			OV - Ovarian serous cystadenocarcinoma(117;0.000286)|Epithelial(96;0.0186)|all cancers(119;0.057)		Lithium(DB01356)	GTGTTCAACAGAGGAGGAAAC	0.443000													32	91					0	0	1	0	0
MRPS36	92259	broad.mit.edu	37	5	68524093	68524093	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:68524093G>A	ENST00000256441.4	+	3	243	c.173G>A	c.(172-174)gGa>gAa	p.G58E	MRPS36_ENST00000507022.1_3'UTR|MRPS36_ENST00000512880.1_5'UTR|MRPS36_ENST00000602380.1_5'UTR	NM_033281.5	NP_150597.1	P82909	RT36_HUMAN	mitochondrial ribosomal protein S36	58					translation	mitochondrial small ribosomal subunit	structural constituent of ribosome			NS(1)|endometrium(1)|large_intestine(2)|liver(1)|lung(1)|urinary_tract(1)	7		Lung NSC(167;5.51e-05)|Prostate(74;0.00634)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.04e-56)|Epithelial(20;8.79e-53)|all cancers(19;2.01e-48)|Lung(70;0.0176)		CATTCTAAAGGAAGTAAATCA	0.353000													36	30					0	0	1	0	0
PBLD	64081	broad.mit.edu	37	10	70048777	70048777	+	Splice_Site	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr10:70048777C>T	ENST00000358769.2	-	7	626		c.e7-1		PBLD_ENST00000432941.1_Splice_Site|PBLD_ENST00000495025.2_Splice_Site|PBLD_ENST00000336578.1_Splice_Site|PBLD_ENST00000309049.4_Splice_Site	NM_022129.3	NP_071412.2	P30039	PBLD_HUMAN	phenazine biosynthesis-like protein domain containing						biosynthetic process		isomerase activity			endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(8)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	21						CTATGGCAGTCTGTGGAGACA	0.502000													36	41					0	0	1	0	0
TEX14	56155	broad.mit.edu	37	17	56679793	56679793	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:56679793C>G	ENST00000389934.3	-	12	1612	c.1495G>C	c.(1495-1497)Gat>Cat	p.D499H	TEX14_ENST00000240361.8_Missense_Mutation_p.D505H|TEX14_ENST00000349033.5_Missense_Mutation_p.D499H	NM_001201457.1|NM_198393.3	NP_001188386.1|NP_938207.2	Q8IWB6	TEX14_HUMAN	testis expressed 14	505	Protein kinase.					cytoplasm	ATP binding|protein kinase activity			breast(6)|endometrium(5)|kidney(3)|large_intestine(22)|liver(1)|lung(24)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	81	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TACCGGATATCTTGAAGGTTC	0.403000													4	31					0	0	1	0	0
CABIN1	23523	broad.mit.edu	37	22	24509642	24509642	+	Missense_Mutation	SNP	G	G	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr22:24509642G>T	ENST00000398319.2	+	27	4612	c.4227G>T	c.(4225-4227)gaG>gaT	p.E1409D	CABIN1_ENST00000263119.5_Missense_Mutation_p.E1409D|CABIN1_ENST00000405822.2_Missense_Mutation_p.E1330D	NM_001199281.1	NP_001186210.1	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	1409					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			breast(2)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(13)|liver(1)|lung(18)|ovary(5)|pancreas(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						CCTACACAGAGAAGAGGCTGC	0.522000													4	138					0.014758	0.0148058	1	1	0
AGGF1	55109	broad.mit.edu	37	5	76342394	76342394	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:76342394G>A	ENST00000312916.7	+	6	1475	c.1093G>A	c.(1093-1095)Gat>Aat	p.D365N		NM_018046.4	NP_060516.2	Q8N302	AGGF1_HUMAN	angiogenic factor with G patch and FHA domains 1	365					angiogenesis|cell adhesion|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|RNA processing|vasculogenesis	extracellular region|perinuclear region of cytoplasm	eukaryotic cell surface binding|nucleic acid binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|liver(2)|lung(4)|ovary(1)|prostate(1)|skin(2)	20		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;4.51e-51)|Epithelial(54;2.2e-45)|all cancers(79;6.68e-41)		CATGGAGACTGATAGTGAACC	0.383000													97	61					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	138000038	138000038	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:138000038C>G	ENST00000409968.1	+	10	2340	c.2162C>G	c.(2161-2163)tCt>tGt	p.S721C	THSD7B_ENST00000413152.2_Missense_Mutation_p.S690C|THSD7B_ENST00000543459.1_Intron|THSD7B_ENST00000272643.3_Missense_Mutation_p.S721C					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		TGTCCAGATTCTACTCGACCT	0.438000													5	47					0	0	1	0	0
ABCA7	10347	broad.mit.edu	37	19	1051274	1051274	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:1051274G>A	ENST00000263094.6	+	20	3036	c.2805G>A	c.(2803-2805)gtG>gtA	p.V935V	ABCA7_ENST00000433129.1_Silent_p.V935V|ABCA7_ENST00000435683.2_Silent_p.V797V	NM_019112.3	NP_061985.2	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 7	935	ABC transporter 1.				phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			NS(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(7)|lung(22)|ovary(1)|pancreas(7)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGCAGAGTGTGCAGACTCGCC	0.642000													19	22					0	0	1	0	0
C4B	721	broad.mit.edu	37	6	31997503	31997503	+	Silent	SNP	A	A	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:31997503A>C	ENST00000435363.2	+	29	3921	c.3837A>C	c.(3835-3837)gcA>gcC	p.A1279A	C4B_ENST00000425700.2_Silent_p.A1279A	NM_001002029.3	NP_001002029.3	P0C0L5	CO4B_HUMAN	complement component 4B (Chido blood group)	1279					complement activation, classical pathway|inflammatory response|innate immune response	extracellular space	endopeptidase inhibitor activity										AGGGCAAAGCAGAGATGGCAG	0.672000													16	43					0	0	1	0	0
POLR2A	5430	broad.mit.edu	37	17	7401049	7401049	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:7401049G>A	ENST00000322644.6	+	7	1461	c.1062G>A	c.(1060-1062)ctG>ctA	p.L354L	POLR2A_ENST00000572844.1_Silent_p.L354L	NM_000937.4	NP_000928	P24928	RPB1_HUMAN	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	354					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(17)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	50		Prostate(122;0.173)				GAGGGAACCTGATGGGCAAAA	0.602000													36	7					0	0	1	0	0
PPL	5493	broad.mit.edu	37	16	4933966	4933966	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr16:4933966C>G	ENST00000345988.2	-	22	4779	c.4690G>C	c.(4690-4692)Gag>Cag	p.E1564Q	PPL_ENST00000590782.2_Missense_Mutation_p.E1562Q	NM_002705.4	NP_002696	O60437	PEPL_HUMAN	periplakin	1564					keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			breast(6)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(12)|lung(12)|ovary(4)|prostate(5)|skin(3)|stomach(1)|urinary_tract(2)	62						TTGTGGTTCTCTTCCCTCAGA	0.552000													56	66					0	0	1	0	0
ZNF397	84307	broad.mit.edu	37	18	32822819	32822819	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr18:32822819G>C	ENST00000330501.7	+	2	538	c.385G>C	c.(385-387)Gag>Cag	p.E129Q	ZNF397_ENST00000355632.4_Missense_Mutation_p.E129Q|ZNF397_ENST00000589420.1_Intron|ZNF397_ENST00000592264.1_Missense_Mutation_p.E129Q|ZNF397_ENST00000591206.1_Missense_Mutation_p.E129Q|ZNF397_ENST00000261333.6_Missense_Mutation_p.E129Q|ZNF397_ENST00000585800.1_Missense_Mutation_p.E129Q	NM_001135178.2	NP_001128650.1	Q8NF99	ZN397_HUMAN	zinc finger protein 397	129	SCAN box.				viral reproduction	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(1)|large_intestine(3)|lung(5)|skin(1)	12						GGAGGATTTAGAGAGGGAGTT	0.502000													14	49					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78314024	78314024	+	Nonsense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:78314024C>T	ENST00000582970.1	+	26	6000	c.5857C>T	c.(5857-5859)Cag>Tag	p.Q1953*	RNF213_ENST00000336301.6_Nonsense_Mutation_p.Q26*|RNF213_ENST00000508628.2_Nonsense_Mutation_p.Q2002*	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			CGTCACCCCCCAGGCACCCCT	0.632000													22	28					0	0	1	0	0
LARP7	51574	broad.mit.edu	37	4	113568079	113568079	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:113568079G>C	ENST00000509061.1	+	7	844	c.541G>C	c.(541-543)Gaa>Caa	p.E181Q	MIR302B_ENST00000505215.1_RNA|LARP7_ENST00000324052.6_Missense_Mutation_p.E174Q|MIR302B_ENST00000510655.1_RNA|MIR302B_ENST00000509938.1_RNA|LARP7_ENST00000344442.5_Missense_Mutation_p.E174Q	NM_001267039.1	NP_001253968.1	Q4G0J3	LARP7_HUMAN	La ribonucleoprotein domain family, member 7	174	RRM.				RNA processing	nucleoplasm|ribonucleoprotein complex	nucleotide binding|RNA binding			endometrium(2)|large_intestine(2)|lung(8)|ovary(4)|skin(1)	17		Ovarian(17;0.0443)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000603)		TGTGGAATTTGAAACAAAAGA	0.308000													63	86					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77618660	77618660	+	Silent	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr8:77618660C>A	ENST00000521891.2	+	2	2785	c.2337C>A	c.(2335-2337)gcC>gcA	p.A779A	ZFHX4_ENST00000455469.2_Silent_p.A779A|ZFHX4_ENST00000517683.1_Intron|ZFHX4_ENST00000518282.1_Silent_p.A779A|ZFHX4_ENST00000050961.6_Silent_p.A779A	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	779						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CCAATGTCGCCAGGAACCTCC	0.498000										HNSCC(33;0.089)			21	39					0.000229342	0.000232087	1	1	0
FAM83H	286077	broad.mit.edu	37	8	144808291	144808291	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr8:144808291C>T	ENST00000388913.3	-	5	3465	c.3340G>A	c.(3340-3342)Gag>Aag	p.E1114K		NM_198488.3	NP_940890	Q6ZRV2	FA83H_HUMAN	family with sequence similarity 83, member H	1114					biomineral tissue development			p.E1114K(1)		central_nervous_system(2)|endometrium(1)|large_intestine(1)|lung(12)|pancreas(1)|prostate(3)|urinary_tract(1)	21	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			TCGCGCTCCTCCGCGCTGGCT	0.652000													23	20					0	0	1	0	0
ZMYM4	9202	broad.mit.edu	37	1	35824751	35824751	+	Nonsense_Mutation	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:35824751C>A	ENST00000314607.6	+	3	391	c.311C>A	c.(310-312)tCa>tAa	p.S104*	ZMYM4_ENST00000373297.2_Nonsense_Mutation_p.S104*|ZMYM4-AS1_ENST00000432683.1_RNA	NM_005095.2	NP_005086.2	Q5VZL5	ZMYM4_HUMAN	zinc finger, MYM-type 4	104					multicellular organismal development		DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(16)|ovary(2)|prostate(3)|skin(2)	54		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CTTGTTTCTTCAATTCATACT	0.343000													4	40					0.00909568	0.00913497	1	1	0
DYNLL2	140735	broad.mit.edu	37	17	56164499	56164499	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:56164499C>T	ENST00000579991.2	+	2	326	c.48C>T	c.(46-48)gaC>gaT	p.D16D		NM_080677.2	NP_542408.1	Q96FJ2	DYL2_HUMAN	dynein, light chain, LC8-type 2						activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|microtubule-based process|transport	centrosome|cytosol|dynein complex|microtubule|myosin complex|plasma membrane	motor activity			lung(3)	3						TGTCTGAGGACATGCAACAGG	0.517000													4	13					0	0	1	0	0
GRIN3A	116443	broad.mit.edu	37	9	104448970	104448970	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr9:104448970G>A	ENST00000361820.3	-	2	1812	c.1212C>T	c.(1210-1212)acC>acT	p.T404T		NM_133445.2	NP_597702.2	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	404					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	GTTGGATCATGGTGGCTGTGG	0.468000													66	10					0	0	1	0	0
IGFALS	3483	broad.mit.edu	37	16	1842424	1842424	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr16:1842424G>C	ENST00000415638.3	-	2	188	c.109C>G	c.(109-111)Ccc>Gcc	p.P37A	IGFALS_ENST00000568221.1_Intron|IGFALS_ENST00000215539.3_Intron	NM_001146006.1|NM_004970.2	NP_001139478.1|NP_004961.1	P35858	ALS_HUMAN	insulin-like growth factor binding protein, acid labile subunit	0	LRRNT.				cell adhesion|signal transduction	soluble fraction	insulin-like growth factor binding			endometrium(2)|lung(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	8						GAGGCTTGGGGAGGCGGCCCG	0.711000													5	5					0	0	1	0	0
FOXJ3	22887	broad.mit.edu	37	1	42654591	42654591	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:42654591C>G	ENST00000372572.1	-	13	1773	c.1462G>C	c.(1462-1464)Gag>Cag	p.E488Q	FOXJ3_ENST00000361346.1_Missense_Mutation_p.E488Q|FOXJ3_ENST00000361776.1_Missense_Mutation_p.E454Q|FOXJ3_ENST00000372571.1_Missense_Mutation_p.E2Q|FOXJ3_ENST00000545068.1_Missense_Mutation_p.E488Q|FOXJ3_ENST00000372573.1_Missense_Mutation_p.E488Q	NM_001198851.1	NP_001185780.1	Q9UPW0	FOXJ3_HUMAN	forkhead box J3	488					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	18	Ovarian(52;0.01)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				CTCATACTCTCCATCAGACCT	0.368000													31	18					0	0	1	0	0
HCRTR2	3062	broad.mit.edu	37	6	55119999	55119999	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:55119999C>T	ENST00000370862.3	+	3	804	c.468C>T	c.(466-468)atC>atT	p.I156I		NM_001526.3	NP_001517.2	O43614	OX2R_HUMAN	hypocretin (orexin) receptor 2	156					feeding behavior	integral to plasma membrane	neuropeptide receptor activity			breast(3)|endometrium(2)|kidney(1)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	46	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			GGTATGCAATCTGTCACCCTT	0.468000													17	56					0	0	1	0	0
CCR9	10803	broad.mit.edu	37	3	45943267	45943267	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:45943267G>A	ENST00000357632.2	+	3	1167	c.987G>A	c.(985-987)gtG>gtA	p.V329V	LZTFL1_ENST00000536047.1_Intron|CCR9_ENST00000355983.2_Silent_p.V317V|LZTFL1_ENST00000539217.1_Intron|CCR9_ENST00000422395.1_3'UTR|CCR9_ENST00000395963.2_Silent_p.V317V	NM_001256369.1|NM_031200.2	NP_001243298.1|NP_112477.1	P51686	CCR9_HUMAN	chemokine (C-C motif) receptor 9	329					cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane				breast(1)|endometrium(4)|large_intestine(8)|lung(2)|ovary(2)|prostate(2)|skin(1)	20				BRCA - Breast invasive adenocarcinoma(193;0.00118)|KIRC - Kidney renal clear cell carcinoma(197;0.0182)|Kidney(197;0.0214)		GGGATCTCGTGAAAACCCTGA	0.512000													39	52					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75797372	75797372	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:75797372G>A	ENST00000322507.8	-	65	9411	c.9102C>T	c.(9100-9102)atC>atT	p.I3034I	COL12A1_ENST00000483888.2_Silent_p.I3030I|COL12A1_ENST00000345356.6_Silent_p.I1870I|COL12A1_ENST00000416123.2_Silent_p.I2958I	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	3034	Triple-helical region (COL1) with 2 imperfections.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						GGGGTCCTCGGATACCTGAGT	0.577000													62	40					0	0	1	0	0
DDX43	55510	broad.mit.edu	37	6	74125923	74125923	+	Nonsense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:74125923C>T	ENST00000370336.4	+	16	2079	c.1921C>T	c.(1921-1923)Caa>Taa	p.Q641*	MB21D1_ENST00000370318.1_Intron	NM_018665.2	NP_061135.2	Q9NXZ2	DDX43_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 43	641						intracellular	ATP binding|ATP-dependent RNA helicase activity|RNA binding			NS(1)|breast(2)|central_nervous_system(1)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	24						GGAAAGACCTCAAGGAAGGCC	0.373000													4	35					0	0	1	0	0
SHCBP1L	81626	broad.mit.edu	37	1	182869222	182869222	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:182869222C>T	ENST00000367547.3	-	10	2094	c.1858G>A	c.(1858-1860)Gat>Aat	p.D620N	SHCBP1L_ENST00000423786.1_Missense_Mutation_p.D501N|SHCBP1L_ENST00000488956.1_5'UTR	NM_030933.2	NP_112195.2	Q9BZQ2	SHP1L_HUMAN	SHC SH2-domain binding protein 1-like	692										breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(2)|pancreas(1)|prostate(1)|skin(2)	15						ATTTTATCATCTTTTTTATCT	0.353000													9	19					0	0	1	0	0
TUBB	203068	broad.mit.edu	37	6	30692163	30692163	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:30692163G>C	ENST00000396389.1	+	4	1863	c.1270G>C	c.(1270-1272)Gag>Cag	p.E424Q	TUBB_ENST00000396384.1_Missense_Mutation_p.E370Q|TUBB_ENST00000435534.1_Missense_Mutation_p.E241Q|TUBB_ENST00000327892.8_Missense_Mutation_p.E442Q|TUBB_ENST00000330914.3_Missense_Mutation_p.E370Q			P07437	TBB5_HUMAN	tubulin, beta class I	442					cellular component movement|G2/M transition of mitotic cell cycle|microtubule-based movement|natural killer cell mediated cytotoxicity|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|MHC class I protein binding			breast(1)|endometrium(1)|kidney(8)|large_intestine(3)|lung(1)|ovary(1)|urinary_tract(1)	16					Colchicine(DB01394)|Vinblastine(DB00570)|Vincristine(DB00541)|Vinorelbine(DB00361)	GGAGGCCGAAGAGGAGGCCTA	0.557000													9	21					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124339327	124339327	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr10:124339327G>A	ENST00000338354.3	+	10	1019	c.913G>A	c.(913-915)Gga>Aga	p.G305R	DMBT1_ENST00000344338.3_Missense_Mutation_p.G305R|DMBT1_ENST00000359586.6_Intron|DMBT1_ENST00000368956.2_Missense_Mutation_p.G305R|DMBT1_ENST00000368955.3_Missense_Mutation_p.G305R|DMBT1_ENST00000330163.4_Missense_Mutation_p.G305R|DMBT1_ENST00000368909.3_Missense_Mutation_p.G305R			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	305	SRCR 2.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GCGCTGCTCAGGACATGAGTC	0.612000													114	123					0	0	1	0	0
VPS9D1	9605	broad.mit.edu	37	16	89774356	89774356	+	Silent	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr16:89774356C>G	ENST00000561976.1	-	14	1976	c.1599G>C	c.(1597-1599)ctG>ctC	p.L533L	VPS9D1_ENST00000389386.3_Silent_p.L603L					VPS9 domain containing 1																		CCTCTCCGATCAGGTACCTGC	0.617000													33	32					0	0	1	0	0
UGGT2	55757	broad.mit.edu	37	13	96506611	96506611	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr13:96506611C>T	ENST00000376747.3	-	35	4197	c.4127G>A	c.(4126-4128)gGa>gAa	p.G1376E		NM_020121.3	NP_064506.3	Q9NYU1	UGGG2_HUMAN	UDP-glucose glycoprotein glucosyltransferase 2	1376	Glucosyltransferase.				post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(17)|lung(20)|ovary(3)|pancreas(1)|prostate(4)|urinary_tract(2)	60						TGCCCAGTATCCTGTTTTCCA	0.383000													7	96					0	0	1	0	0
ACSL1	2180	broad.mit.edu	37	4	185687901	185687901	+	Nonsense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:185687901G>A	ENST00000515030.1	-	13	1463	c.1138C>T	c.(1138-1140)Caa>Taa	p.Q380*	ACSL1_ENST00000513317.1_Nonsense_Mutation_p.Q380*|ACSL1_ENST00000454703.2_Nonsense_Mutation_p.Q209*|ACSL1_ENST00000281455.2_Nonsense_Mutation_p.Q380*|ACSL1_ENST00000437665.3_Nonsense_Mutation_p.Q209*|ACSL1_ENST00000507295.1_Nonsense_Mutation_p.Q346*|ACSL1_ENST00000504342.1_Nonsense_Mutation_p.Q380*			P33121	ACSL1_HUMAN	acyl-CoA synthetase long-chain family member 1	380					digestion|fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|regulation of fatty acid oxidation|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|liver(1)|lung(17)|ovary(2)|prostate(1)|skin(2)	38		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00172)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0315)|all_neural(102;0.107)|Medulloblastoma(177;0.146)		all cancers(43;1.33e-28)|Epithelial(43;5.3e-25)|OV - Ovarian serous cystadenocarcinoma(60;4.88e-11)|Colorectal(24;3.59e-06)|STAD - Stomach adenocarcinoma(60;2.72e-05)|GBM - Glioblastoma multiforme(59;2.83e-05)|BRCA - Breast invasive adenocarcinoma(30;7.66e-05)|COAD - Colon adenocarcinoma(29;0.000538)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.0419)	Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	GTGTTTGCTTGTCCGAAAATC	0.493000													27	30					0	0	1	0	0
PCDH8	5100	broad.mit.edu	37	13	53422340	53422340	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr13:53422340C>T	ENST00000377942.3	-	1	435	c.232G>A	c.(232-234)Gaa>Aaa	p.E78K	PCDH8_ENST00000338862.4_Missense_Mutation_p.E78K	NM_002590.3	NP_002581.2	O95206	PCDH8_HUMAN	protocadherin 8	78	Cadherin 1.				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(23)|ovary(1)|skin(1)|urinary_tract(1)	36		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		CCGTCGCCTTCGCGCACCCGG	0.652000													63	45					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57604261	57604261	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:57604261C>G	ENST00000243077.3	+	82	13218	c.12752C>G	c.(12751-12753)tCt>tGt	p.S4251C		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	4251	EGF-like 18.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GCCTCCCCCTCTGGTATGCCC	0.692000													17	11					0	0	1	0	0
GTF3C2	2976	broad.mit.edu	37	2	27552304	27552304	+	Nonsense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:27552304G>A	ENST00000359541.2	-	13	2248	c.1819C>T	c.(1819-1821)Cag>Tag	p.Q607*	GTF3C2_ENST00000264720.3_Nonsense_Mutation_p.Q607*			Q8WUA4	TF3C2_HUMAN	general transcription factor IIIC, polypeptide 2, beta 110kDa	607						transcription factor TFIIIC complex				central_nervous_system(4)|endometrium(6)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(2)	38	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGGAAACACTGGAAGGGGTAG	0.522000													174	160					0	0	1	0	0
GLTSCR1	29998	broad.mit.edu	37	19	48205572	48205572	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:48205572C>T	ENST00000396720.3	+	15	4777	c.4583C>T	c.(4582-4584)tCg>tTg	p.S1528L	CTD-2571L23.8_ENST00000599924.1_lincRNA	NM_015711.3	NP_056526.3	Q9NZM4	GSCR1_HUMAN	glioma tumor suppressor candidate region gene 1	1528							protein binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|pancreas(3)|prostate(4)|skin(2)	20		all_cancers(25;1.8e-07)|all_lung(116;5.73e-06)|Lung NSC(112;9.69e-06)|all_epithelial(76;2.42e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		all cancers(93;0.000358)|OV - Ovarian serous cystadenocarcinoma(262;0.000576)|Epithelial(262;0.0212)|GBM - Glioblastoma multiforme(486;0.0355)		CACGCTGCCTCGGCCGGCACC	0.721000													3	19					0	0	1	0	0
MAZ	4150	broad.mit.edu	37	16	29818771	29818771	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr16:29818771C>G	ENST00000219782.6	+	2	771	c.665C>G	c.(664-666)tCg>tGg	p.S222W	AC009133.15_ENST00000566537.1_RNA|MAZ_ENST00000563402.1_Intron|MAZ_ENST00000566906.2_Intron|MAZ_ENST00000545521.1_Missense_Mutation_p.S199W|MAZ_ENST00000322945.6_Missense_Mutation_p.S222W|MAZ_ENST00000562337.1_Intron	NM_001042539.1	NP_001036004.1	P56270	MAZ_HUMAN	MYC-associated zinc finger protein (purine-binding transcription factor)	222					regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription|transcription initiation from RNA polymerase II promoter	nucleus	DNA binding|protein binding|RNA binding|zinc ion binding			endometrium(3)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	10						CGGGTCCCCTCGGGTGCTATG	0.692000													4	68					0	0	1	0	0
NUP155	9631	broad.mit.edu	37	5	37326013	37326013	+	Missense_Mutation	SNP	T	T	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:37326013T>A	ENST00000231498.3	-	19	2284	c.2081A>T	c.(2080-2082)gAg>gTg	p.E694V	NUP155_ENST00000381843.2_Missense_Mutation_p.E635V|NUP155_ENST00000513532.1_Missense_Mutation_p.E694V	NM_153485.1	NP_705618.1	O75694	NU155_HUMAN	nucleoporin 155kDa	694					carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			endometrium(1)|kidney(16)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	62	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TGCAGTGATCTCTCTGTTGCC	0.313000													69	56					0	0	1	0	0
KLHL9	55958	broad.mit.edu	37	9	21334109	21334109	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr9:21334109G>A	ENST00000359039.4	-	1	1270	c.750C>T	c.(748-750)ctC>ctT	p.L250L	KLHL9_ENST00000537938.1_Silent_p.L182L			Q9P2J3	KLHL9_HUMAN	kelch-like family member 9	250	BACK.				cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex|midbody				endometrium(9)|large_intestine(7)|lung(10)|ovary(4)|skin(2)	32				Lung(24;8.52e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.118)		CGTAATTGATGAGATCCTGTG	0.433000													4	70					0	0	1	0	0
IRS1	3667	broad.mit.edu	37	2	227661379	227661379	+	Silent	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:227661379C>G	ENST00000305123.5	-	1	3096	c.2076G>C	c.(2074-2076)ggG>ggC	p.G692G		NM_005544.2	NP_005535.1	P35568	IRS1_HUMAN	insulin receptor substrate 1						fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(5)|kidney(4)|large_intestine(10)|lung(33)|ovary(6)|pancreas(1)|prostate(1)|urinary_tract(2)	69		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		CATAGCTGGTCCCGGAAGGGA	0.617000											OREG0015248	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	38	45					0	0	1	0	0
EPS15L1	58513	broad.mit.edu	37	19	16551699	16551699	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:16551699C>T	ENST00000597937.1	-	4	191	c.187G>A	c.(187-189)Gaa>Aaa	p.E63K	EPS15L1_ENST00000248070.6_Missense_Mutation_p.E63K|EPS15L1_ENST00000594975.1_Missense_Mutation_p.E63K|EPS15L1_ENST00000455140.2_Missense_Mutation_p.E63K|EPS15L1_ENST00000535753.2_Missense_Mutation_p.E63K	NM_001258376.1	NP_001245305.1	Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway substrate 15-like 1	63	EH 1.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(12)|ovary(4)|skin(2)	30						CCTTTACCTTCTGGATCGGCC	0.527000													14	576					0	0	1	0	0
INTS5	80789	broad.mit.edu	37	11	62415019	62415019	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:62415019G>C	ENST00000330574.2	-	2	2585	c.2533C>G	c.(2533-2535)Ctc>Gtc	p.L845V		NM_030628.1	NP_085131.1	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	845					snRNA processing	integral to membrane|integrator complex	protein binding			breast(1)|endometrium(4)|large_intestine(6)|lung(20)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	36						CCAATGCGGAGATCCCGCTCC	0.652000													50	58					0	0	1	0	0
AC015849.16	0	broad.mit.edu	37	17	34236422	34236422	+	RNA	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:34236422G>A	ENST00000587132.1	-	0	1605																											GGTGACATTGGATGCTGAGCT	0.498000													14	41					0	0	1	0	0
ALPK1	80216	broad.mit.edu	37	4	113353310	113353310	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:113353310C>T	ENST00000458497.1	+	11	2886	c.2607C>T	c.(2605-2607)caC>caT	p.H869H	ALPK1_ENST00000504176.2_Silent_p.H791H|ALPK1_ENST00000177648.9_Silent_p.H869H	NM_001102406.1|NM_025144.3	NP_001095876.1|NP_079420.3	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	869							ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(20)|ovary(6)|prostate(2)|urinary_tract(1)	53		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		CAAATGGGCACGGCTCTCATA	0.597000													35	43					0	0	1	0	0
PYHIN1	149628	broad.mit.edu	37	1	158912136	158912136	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:158912136C>G	ENST00000368140.1	+	5	1194	c.949C>G	c.(949-951)Ctt>Gtt	p.L317V	PYHIN1_ENST00000485134.1_3'UTR|PYHIN1_ENST00000368138.3_Missense_Mutation_p.L308V|PYHIN1_ENST00000392252.3_Missense_Mutation_p.L308V|PYHIN1_ENST00000392254.2_Missense_Mutation_p.L317V	NM_152501.4|NM_198928.4|NM_198929.4	NP_689714.2|NP_945146.1|NP_945147.1	Q6K0P9	IFIX_HUMAN	pyrin and HIN domain family, member 1	317	HIN-200.				cell cycle	nuclear speck				breast(2)|endometrium(3)|large_intestine(10)|lung(32)|ovary(3)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_hematologic(112;0.0378)					GATCAATATTCTTCACAAACA	0.363000													66	29					0	0	1	0	0
GRM4	2914	broad.mit.edu	37	6	34101214	34101214	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:34101214G>A	ENST00000538487.2	-	2	503	c.60C>T	c.(58-60)ctC>ctT	p.L20L	GRM4_ENST00000374177.3_Intron|GRM4_ENST00000374181.4_Silent_p.L20L	NM_000841.2|NM_001256811.1	NP_000832.1|NP_001243740.1	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4						activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48					L-Glutamic Acid(DB00142)	CGTAAAGGCTGAGGAGCAGGC	0.622000													28	22					0	0	1	0	0
ZBTB14	7541	broad.mit.edu	37	18	5290905	5290905	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr18:5290905C>T	ENST00000357006.4	-	4	1640	c.1302G>A	c.(1300-1302)gcG>gcA	p.A434A	ZBTB14_ENST00000400143.3_Silent_p.A434A	NM_001143823.2|NM_001243704.1	NP_001137295.1|NP_001230633.1			zinc finger and BTB domain containing 14																		CCGCAGCCATCGCTGCCGCCT	0.552000													64	44					0	0	1	0	0
ACOX1	51	broad.mit.edu	37	17	73974731	73974731	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:73974731C>G	ENST00000537812.1	-	2	687	c.39G>C	c.(37-39)ttG>ttC	p.L13F	ACOX1_ENST00000301608.4_Missense_Mutation_p.L51F|ACOX1_ENST00000591857.1_5'UTR|ACOX1_ENST00000293217.5_Missense_Mutation_p.L51F	NM_001185039.1	NP_001171968.1	Q15067	ACOX1_HUMAN	acyl-CoA oxidase 1, palmitoyl	51					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|prostaglandin metabolic process|very long-chain fatty acid metabolic process	peroxisomal matrix	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity|flavin adenine dinucleotide binding|protein N-terminus binding			large_intestine(2)|lung(7)|ovary(2)|prostate(2)|skin(1)	14						TGAGGAAGTTCAAGTCCTCAT	0.517000													31	39					0	0	1	0	0
CLCN2	1181	broad.mit.edu	37	3	184074862	184074862	+	Missense_Mutation	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:184074862C>A	ENST00000265593.4	-	10	1175	c.1004G>T	c.(1003-1005)gGa>gTa	p.G335V	CLCN2_ENST00000434054.2_Missense_Mutation_p.G291V|CLCN2_ENST00000423355.2_5'UTR|EIF2B5_ENST00000444495.1_Intron|CLCN2_ENST00000344937.7_Missense_Mutation_p.G335V|CLCN2_ENST00000457512.1_Missense_Mutation_p.G335V	NM_004366.5	NP_004357.3	P51788	CLCN2_HUMAN	chloride channel, voltage-sensitive 2	335						chloride channel complex	voltage-gated chloride channel activity			breast(2)|central_nervous_system(4)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	27	all_cancers(143;6.66e-11)|Ovarian(172;0.0339)		Epithelial(37;2.22e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Lubiprostone(DB01046)	AAAGAGGGCTCCACCGAAGCC	0.552000													12	7					5.50884e-06	5.66728e-06	1	1	0
ITGB4	3691	broad.mit.edu	37	17	73733438	73733438	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:73733438G>A	ENST00000200181.3	+	17	2213	c.2026G>A	c.(2026-2028)Gag>Aag	p.E676K	ITGB4_ENST00000584558.1_3'UTR|ITGB4_ENST00000339591.3_Missense_Mutation_p.E676K|ITGB4_ENST00000449880.2_Missense_Mutation_p.E676K|ITGB4_ENST00000579662.1_Missense_Mutation_p.E676K|ITGB4_ENST00000450894.3_Missense_Mutation_p.E676K	NM_000213.3	NP_000204.3	P16144	ITB4_HUMAN	integrin, beta 4	676				IHPGLCEDLRSCVQCQAWGTGEKKGRTCEECNFKVKMVDEL KRAEEVVVRCSFRDEDDDCTYSYTMEGDGAPGPNSTVLVHK KK -> STRASARTYAPACSARRGAPARRRGARVRNATSRS RWWTSLREARRWWCAAPSGTRMTTAPTATPWKVTAPLGPTA LSWCTRRR (in Ref. 5; CAB61345).	cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(1)|lung(25)|skin(1)|urinary_tract(1)	43	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			CTTCCGGGACGAGGATGACGA	0.662000													3	8					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48623284	48623284	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:48623284C>T	ENST00000328333.8	-	29	3872	c.3765G>A	c.(3763-3765)caG>caA	p.Q1255Q	COL7A1_ENST00000454817.1_Silent_p.Q1255Q	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	1255	Interrupted collagenous region.|Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity	p.Q1255H(1)		NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GTTCCCCCTTCTGGCCCTGGG	0.582000													20	335					0	0	1	0	0
SCARB1	949	broad.mit.edu	37	12	125271987	125271987	+	Nonsense_Mutation	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:125271987C>A	ENST00000339570.5	-	10	1415	c.1219G>T	c.(1219-1221)Gag>Tag	p.E407*	SCARB1_ENST00000376788.1_Nonsense_Mutation_p.E307*|SCARB1_ENST00000546215.1_Nonsense_Mutation_p.E407*|SCARB1_ENST00000261693.6_Nonsense_Mutation_p.E407*|SCARB1_ENST00000540495.1_Nonsense_Mutation_p.E370*|SCARB1_ENST00000535005.1_5'UTR|SCARB1_ENST00000415380.2_Nonsense_Mutation_p.E407*|SCARB1_ENST00000544327.1_Nonsense_Mutation_p.E353*|SCARB1_ENST00000541205.1_Nonsense_Mutation_p.E366*	NM_001082959.1	NP_001076428.1	Q8WTV0	SCRB1_HUMAN	scavenger receptor class B, member 1	407					adhesion to symbiont|cell adhesion|cholesterol efflux|cholesterol homeostasis|cholesterol import|detection of lipopolysaccharide|high-density lipoprotein particle clearance|high-density lipoprotein particle remodeling|lipopolysaccharide transport|lipoprotein metabolic process|positive regulation of cholesterol storage|positive regulation of endothelial cell migration|positive regulation of nitric-oxide synthase activity|recognition of apoptotic cell|reverse cholesterol transport|triglyceride homeostasis|wound healing	caveola	1-phosphatidylinositol binding|apolipoprotein A-I binding|high-density lipoprotein particle receptor activity|lipopolysaccharide receptor activity|low-density lipoprotein particle binding|phosphatidylserine binding|transporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(7)|prostate(1)	17	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000116)|Epithelial(86;0.000415)|all cancers(50;0.00395)	Phosphatidylserine(DB00144)	ACCACAGGCTCAATCTTCCCA	0.478000													13	6					9.31168e-06	9.56891e-06	1	1	0
TMEM108	66000	broad.mit.edu	37	3	133098718	133098718	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:133098718C>T	ENST00000515826.1	+	3	286	c.163C>T	c.(163-165)Cac>Tac	p.H55Y	TMEM108_ENST00000393130.3_Missense_Mutation_p.H55Y|TMEM108_ENST00000508711.1_Intron|TMEM108_ENST00000321871.6_Missense_Mutation_p.H55Y			Q6UXF1	TM108_HUMAN	transmembrane protein 108	55						integral to membrane				endometrium(3)|kidney(1)|large_intestine(5)|lung(22)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38						GACAGCACCCCACAGCTCTAC	0.612000													79	133					0	0	1	0	0
POLQ	10721	broad.mit.edu	37	3	121215661	121215661	+	Missense_Mutation	SNP	A	A	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:121215661A>G	ENST00000264233.5	-	14	2400	c.2272T>C	c.(2272-2274)Tat>Cat	p.Y758H		NM_199420.3	NP_955452.3	O75417	DPOLQ_HUMAN	polymerase (DNA directed), theta	758					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(55)|ovary(5)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	120				GBM - Glioblastoma multiforme(114;0.0915)		TGACCTGCATAAACAGCAGCT	0.338000								DNA polymerases (catalytic subunits)					41	25					0	0	1	0	0
OPRL1	4987	broad.mit.edu	37	20	62730084	62730084	+	Missense_Mutation	SNP	G	G	A	rs138440707		TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr20:62730084G>A	ENST00000349451.3	+	6	1457	c.1045G>A	c.(1045-1047)Gtg>Atg	p.V349M	OPRL1_ENST00000336866.2_Missense_Mutation_p.V349M|OPRL1_ENST00000355631.4_Missense_Mutation_p.V349M	NM_001200019.1	NP_001186948.1	P41146	OPRX_HUMAN	opiate receptor-like 1	349					elevation of cytosolic calcium ion concentration|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception	integral to plasma membrane	protein binding|X-opioid receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(38;4.74e-11)|all_epithelial(29;1.33e-12)|Lung NSC(23;3.27e-09)|all_lung(23;1.02e-08)					GTCTGACCGCGTGCGCAGCAT	0.642000													31	76					0	0	1	0	0
PTGDR2	11251	broad.mit.edu	37	11	60620887	60620887	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:60620887G>C	ENST00000332539.4	-	2	420	c.309C>G	c.(307-309)ttC>ttG	p.F103L		NM_004778.2	NP_004769.2	Q9Y5Y4	GPR44_HUMAN	prostaglandin D2 receptor 2	103					immune response	integral to plasma membrane	N-formyl peptide receptor activity										GCAGTTTGCAGAAGGTGGTGC	0.632000													7	9					0	0	1	0	0
TAS2R8	50836	broad.mit.edu	37	12	10958929	10958929	+	Silent	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:10958929G>C	ENST00000240615.2	-	1	963	c.651C>G	c.(649-651)ctC>ctG	p.L217L		NM_023918.1	NP_076407.1	Q9NYW2	TA2R8_HUMAN	taste receptor, type 2, member 8	217					sensory perception of taste	integral to membrane	taste receptor activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						CGGTAGCATAGAGTTTTATTT	0.343000													43	26					0	0	1	0	0
GSTM2	2946	broad.mit.edu	37	1	110211953	110211953	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:110211953C>T	ENST00000369831.2	+	4	313	c.219C>T	c.(217-219)agC>agT	p.S73S	GSTM2_ENST00000414179.2_5'UTR|GSTM2_ENST00000464206.1_3'UTR|GSTM2_ENST00000369827.3_Silent_p.S71S|GSTM2_ENST00000442650.1_Silent_p.S73S|GSTM2_ENST00000241337.4_Silent_p.S73S|GSTM2_ENST00000369829.2_Silent_p.S73S|GSTM2_ENST00000460717.3_Silent_p.S73S					glutathione S-transferase mu 2 (muscle)											kidney(1)|large_intestine(2)|lung(4)|prostate(2)|upper_aerodigestive_tract(2)	11		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		all cancers(265;0.0122)|Colorectal(144;0.0129)|Epithelial(280;0.0146)|Lung(183;0.0422)|COAD - Colon adenocarcinoma(174;0.047)|LUSC - Lung squamous cell carcinoma(189;0.227)		TCACCCAGAGCAACGCCATCC	0.592000													126	105					0	0	1	0	0
CC2D1B	200014	broad.mit.edu	37	1	52824767	52824767	+	Missense_Mutation	SNP	C	C	T	rs144724390	byFrequency	TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:52824767C>T	ENST00000371586.2	-	11	1327	c.1189G>A	c.(1189-1191)Gag>Aag	p.E397K	CC2D1B_ENST00000438831.1_5'UTR|CC2D1B_ENST00000460261.1_5'UTR|CC2D1B_ENST00000284376.3_Missense_Mutation_p.E397K	NM_032449.2	NP_115825.1	Q5T0F9	C2D1B_HUMAN	coiled-coil and C2 domain containing 1B	397										breast(1)|large_intestine(6)|lung(13)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	27						ATGCCCGCCTCGCGGTACTTG	0.632000													7	42					0	0	1	0	0
UBAP2	55833	broad.mit.edu	37	9	33935847	33935847	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr9:33935847C>G	ENST00000379238.1	-	17	2076	c.1959G>C	c.(1957-1959)caG>caC	p.Q653H	UBAP2_ENST00000418786.2_Missense_Mutation_p.Q600H|UBAP2_ENST00000360802.1_Missense_Mutation_p.Q653H|UBAP2_ENST00000379225.1_Missense_Mutation_p.Q286H|UBAP2_ENST00000379239.4_Missense_Mutation_p.Q386H|UBAP2_ENST00000539807.1_Missense_Mutation_p.Q408H|UBAP2_ENST00000449054.1_Missense_Mutation_p.Q653H			Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2	653										endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(13)|ovary(3)|stomach(1)	32			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		TGTCTAGTGTCTGCTGACTTC	0.413000													31	9					0	0	1	0	0
JMY	133746	broad.mit.edu	37	5	78587035	78587035	+	Silent	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:78587035C>G	ENST00000396137.4	+	4	1902	c.1440C>G	c.(1438-1440)ctC>ctG	p.L480L		NM_152405.4	NP_689618.4	Q8N9B5	JMY_HUMAN	junction mediating and regulatory protein, p53 cofactor	480	Interaction with p300/EP300 (By similarity).				'de novo' actin filament nucleation|actin polymerization-dependent cell motility|Arp2/3 complex-mediated actin nucleation|cell cycle arrest|DNA repair|induction of apoptosis|positive regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter	cell leading edge|cytoplasm|cytoskeleton|nucleus	actin binding|transcription coactivator activity			endometrium(4)|kidney(2)|large_intestine(2)|lung(6)|skin(1)|urinary_tract(1)	16		all_lung(232;0.00051)|Lung NSC(167;0.00131)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;4.45e-45)|Epithelial(54;5.85e-40)|all cancers(79;2.89e-35)		TGGAAAAACTCCAGTATGCAG	0.393000													4	77					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49425902	49425902	+	Nonsense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:49425902G>A	ENST00000301067.7	-	39	12585	c.12586C>T	c.(12586-12588)Cag>Tag	p.Q4196*		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		GCTCGAAGCTGACCCACCGTA	0.587000													15	50					0	0	1	0	0
RP11-478B9.1	0	broad.mit.edu	37	12	45457582	45457582	+	RNA	SNP	G	G	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:45457582G>T	ENST00000548424.1	+	0	448																											GTTGACACTTGATGTCCTGTA	0.498000													13	26					0.000151284	0.000153597	1	1	0
B3GNTL1	146712	broad.mit.edu	37	17	80992923	80992923	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:80992923G>C	ENST00000320865.3	-	4	343	c.330C>G	c.(328-330)tgC>tgG	p.C110W	B3GNTL1_ENST00000571954.1_5'UTR|B3GNTL1_ENST00000576599.1_5'UTR	NM_001009905.1	NP_001009905.1	Q67FW5	B3GNL_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1	110							transferase activity, transferring glycosyl groups			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	8	Breast(20;0.000443)|all_neural(118;0.0779)	all_cancers(8;0.0396)|all_epithelial(8;0.0556)	BRCA - Breast invasive adenocarcinoma(99;0.0517)|OV - Ovarian serous cystadenocarcinoma(97;0.0868)			AATCCAAAAAGCAAAGGTAAG	0.343000													20	80					0	0	1	0	0
COPA	1314	broad.mit.edu	37	1	160280027	160280027	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:160280027G>A	ENST00000241704.7	-	12	1327	c.1098C>T	c.(1096-1098)ttC>ttT	p.F366F	COPA_ENST00000368069.3_Silent_p.F366F	NM_001098398.1|NM_004371.3	NP_001091868.1|NP_004362.2	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha	366					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(2)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(2)	46	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			ATGACATATTGAATACTGGAA	0.413000													6	210					0	0	1	0	0
TMEM245	23731	broad.mit.edu	37	9	111855810	111855810	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr9:111855810G>A	ENST00000374586.3	-	4	892	c.861C>T	c.(859-861)atC>atT	p.I287I		NM_032012.3	NP_114401.2	Q9H330	CI005_HUMAN	transmembrane protein 245	287						integral to membrane											CTGTGATAGAGATGGCCAAGT	0.453000													43	4					0	0	1	0	0
RAB2B	84932	broad.mit.edu	37	14	21945011	21945011	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr14:21945011G>A	ENST00000397762.1	-	1	121	c.21C>T	c.(19-21)ttC>ttT	p.F7F	TOX4_ENST00000405508.1_5'UTR	NM_001163380.1|NM_032846.3	NP_001156852.1|NP_116235.2	Q8WUD1	RAB2B_HUMAN	RAB2B, member RAS oncogene family	7					protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane|plasma membrane	GTP binding			NS(1)|central_nervous_system(1)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)	6	all_cancers(95;0.000858)		Epithelial(56;1.53e-06)|all cancers(55;1.44e-05)	GBM - Glioblastoma multiforme(265;0.00391)		TGATATACTTGAAGAGATAAG	0.572000											OREG0022569	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	77	11					0	0	1	0	0
OSMR	9180	broad.mit.edu	37	5	38886188	38886188	+	Missense_Mutation	SNP	G	G	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:38886188G>T	ENST00000274276.3	+	7	1289	c.887G>T	c.(886-888)tGg>tTg	p.W296L	OSMR_ENST00000502536.1_Missense_Mutation_p.W296L	NM_003999.2	NP_003990.1	Q99650	OSMR_HUMAN	oncostatin M receptor	296					cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	46	all_lung(31;0.000365)					TGGTGTAATTGGCAAATAACT	0.318000													77	51					2.65773e-34	2.90105e-34	1	1	0
ASIC4	55515	broad.mit.edu	37	2	220379725	220379725	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:220379725G>A	ENST00000358078.4	+	1	674	c.660G>A	c.(658-660)ctG>ctA	p.L220L	AC053503.11_ENST00000429882.1_RNA|ASIC4_ENST00000347842.3_Silent_p.L220L			Q96FT7	ACCN4_HUMAN	acid-sensing (proton-gated) ion channel family member 4	220						integral to plasma membrane	sodium channel activity|sodium ion transmembrane transporter activity										GGGGCTACCTGACCCGGCCTC	0.697000													12	18					0	0	1	0	0
SEC14L4	284904	broad.mit.edu	37	22	30886159	30886159	+	Missense_Mutation	SNP	G	G	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr22:30886159G>T	ENST00000392772.2	-	12	1315	c.1038C>A	c.(1036-1038)ttC>ttA	p.F346L	SEC14L4_ENST00000381982.3_Intron|SEC14L4_ENST00000255858.7_Missense_Mutation_p.P386T|RP4-539M6.14_ENST00000610156.1_RNA|SEC14L4_ENST00000540456.1_Missense_Mutation_p.P371T			Q9UDX3	S14L4_HUMAN	SEC14-like 4 (S. cerevisiae)	0	GOLD.					integral to membrane|intracellular	lipid binding|transporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(5)|pancreas(1)|skin(1)	21					Vitamin E(DB00163)	GCCTTGTCGGGAAGCAGCACC	0.587000													11	38					4.3838e-07	4.55523e-07	1	1	0
MAP2K3	5606	broad.mit.edu	37	17	21201752	21201752	+	Missense_Mutation	SNP	G	G	T	rs144032462	by1000genomes	TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:21201752G>T	ENST00000342679.4	+	2	326	c.77G>T	c.(76-78)cGg>cTg	p.R26L	MAP2K3_ENST00000316920.6_5'UTR|MAP2K3_ENST00000361818.5_5'UTR	NM_145109.2	NP_659731.1	P46734	MP2K3_HUMAN	mitogen-activated protein kinase kinase 3	26			R -> T.		activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of transcription, DNA-dependent|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity								COAD - Colon adenocarcinoma(3;0.0131)|Colorectal(15;0.0553)		AAGGATCTACGGATATCCTGC	0.557000													73	173					1.38705e-31	1.50872e-31	1	1	0
LRRC41	10489	broad.mit.edu	37	1	46751045	46751045	+	Missense_Mutation	SNP	A	A	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:46751045A>T	ENST00000343304.6	-	4	1769	c.1484T>A	c.(1483-1485)cTc>cAc	p.L495H	LRRC41_ENST00000472710.1_5'UTR	NM_006369.4	NP_006360.3	Q15345	LRC41_HUMAN	leucine rich repeat containing 41	495										breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(7)|ovary(3)|pancreas(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	28	Acute lymphoblastic leukemia(166;0.155)					ATTGTAGGAGAGTGTGAGGCT	0.562000													13	17					0	0	1	0	0
LILRA1	11024	broad.mit.edu	37	19	55106754	55106754	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:55106754C>T	ENST00000453777.1	+	5	718	c.548C>T	c.(547-549)tCt>tTt	p.S183F	LILRB1_ENST00000448689.1_Intron|LILRA1_ENST00000251372.3_Missense_Mutation_p.S183F|LILRA1_ENST00000473156.1_3'UTR|LILRB1_ENST00000396321.2_Intron|LILRB1_ENST00000418536.2_Intron	NM_001278318.1	NP_001265247.1	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	183	Ig-like C2-type 2.				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	47				GBM - Glioblastoma multiforme(193;0.0348)		GCCATCTTCTCTGTGGGCCCC	0.567000													114	83					0	0	1	0	0
LONRF1	91694	broad.mit.edu	37	8	12583373	12583373	+	Nonsense_Mutation	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr8:12583373C>A	ENST00000398246.3	-	11	2095	c.2026G>T	c.(2026-2028)Gag>Tag	p.E676*	LONRF1_ENST00000533751.1_Nonsense_Mutation_p.E319*|LONRF1_ENST00000525024.1_Nonsense_Mutation_p.E102*	NM_152271.3	NP_689484.3	Q17RB8	LONF1_HUMAN	LON peptidase N-terminal domain and ring finger 1	676	Lon.				proteolysis		ATP-dependent peptidase activity|zinc ion binding	p.E676K(1)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(4)|ovary(1)|upper_aerodigestive_tract(2)	19				READ - Rectum adenocarcinoma(644;0.236)		TTCTTAATCTCATCTTCATTC	0.403000													3	27					6.4e-05	6.51204e-05	1	1	0
ATN1	1822	broad.mit.edu	37	12	7046397	7046397	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:7046397G>C	ENST00000356654.4	+	5	2204	c.1967G>C	c.(1966-1968)gGa>gCa	p.G656A	ATN1_ENST00000396684.2_Missense_Mutation_p.G656A	NM_001007026.1	NP_001007027.1	P54259	ATN1_HUMAN	atrophin 1	656					cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			breast(5)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(15)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	40						ACCCCACCCGGATACAAACCC	0.692000													12	19					0	0	1	0	0
PPL	5493	broad.mit.edu	37	16	4933756	4933756	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr16:4933756C>T	ENST00000345988.2	-	22	4989	c.4900G>A	c.(4900-4902)Gac>Aac	p.D1634N	PPL_ENST00000590782.2_Missense_Mutation_p.D1632N	NM_002705.4	NP_002696	O60437	PEPL_HUMAN	periplakin	1634					keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			breast(6)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(12)|lung(12)|ovary(4)|prostate(5)|skin(3)|stomach(1)|urinary_tract(2)	62						TGCAGCTCGTCGATCTCGAGG	0.632000													25	25					0	0	1	0	0
ARHGEF10	9639	broad.mit.edu	37	8	1905208	1905208	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr8:1905208C>G	ENST00000518288.1	+	30	4049	c.3886C>G	c.(3886-3888)Cta>Gta	p.L1296V	ARHGEF10_ENST00000520359.1_Missense_Mutation_p.L1234V|ARHGEF10_ENST00000262112.6_Missense_Mutation_p.L1268V|ARHGEF10_ENST00000349830.3_Missense_Mutation_p.L1272V|ARHGEF10_ENST00000398564.1_Missense_Mutation_p.L1297V|ARHGEF10_ENST00000521927.1_3'UTR			O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor (GEF) 10	1297	Ser-rich.				centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			endometrium(3)|large_intestine(11)|lung(11)|prostate(3)|skin(3)|stomach(3)|urinary_tract(1)	35		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)		CTCCAGCTCTCTAGAGCACAG	0.567000													5	51					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152477102	152477102	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:152477102C>G	ENST00000367255.5	-	132	24522	c.23921G>C	c.(23920-23922)aGa>aCa	p.R7974T	SYNE1_ENST00000448038.1_Missense_Mutation_p.R7903T|SYNE1_ENST00000341594.5_Missense_Mutation_p.R7586T|SYNE1_ENST00000539504.1_Missense_Mutation_p.R129T|SYNE1_ENST00000423061.1_Missense_Mutation_p.R7903T|SYNE1_ENST00000356820.4_Missense_Mutation_p.R2498T|SYNE1_ENST00000265368.4_Missense_Mutation_p.R7974T|SYNE1_ENST00000347037.5_5'UTR|SYNE1_ENST00000354674.4_Missense_Mutation_p.R129T	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	7974					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GTCCAGGTTTCTCGTAGCCTG	0.527000										HNSCC(10;0.0054)			24	69					0	0	1	0	0
TBC1D8B	54885	broad.mit.edu	37	X	106110053	106110053	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chrX:106110053G>A	ENST00000357242.5	+	17	2863	c.2689G>A	c.(2689-2691)Gag>Aag	p.E897K	TBC1D8B_ENST00000276175.3_Missense_Mutation_p.E891K	NM_017752.2	NP_060222.2	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	897						intracellular	calcium ion binding|Rab GTPase activator activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|liver(4)|lung(15)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						AAGTTTTACTGAGAAGCTTAA	0.299000													45	5					0	0	1	0	0
GPATCH3	63906	broad.mit.edu	37	1	27220740	27220740	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:27220740C>T	ENST00000361720.5	-	3	1061	c.1038G>A	c.(1036-1038)caG>caA	p.Q346Q		NM_022078.2	NP_071361.2	Q96I76	GPTC3_HUMAN	G patch domain containing 3	346						intracellular	nucleic acid binding			endometrium(2)|large_intestine(1)|lung(11)|skin(1)	15		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;3.97e-51)|OV - Ovarian serous cystadenocarcinoma(117;9.55e-30)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|STAD - Stomach adenocarcinoma(196;0.000595)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|READ - Rectum adenocarcinoma(331;0.0419)		CTTCTTCCTCCTGCCAGAACT	0.552000													45	72					0	0	1	0	0
C8orf76	84933	broad.mit.edu	37	8	124232391	124232391	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr8:124232391G>A	ENST00000276704.4	-	6	1146	c.1095C>T	c.(1093-1095)ttC>ttT	p.F365F		NM_032847.2	NP_116236.1	Q96K31	CH076_HUMAN	chromosome 8 open reading frame 76	365							binding			NS(1)|lung(9)|ovary(2)|prostate(1)|urinary_tract(4)	17	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			CAAATGGACAGAAATGGTCTT	0.388000													4	50					0	0	1	0	0
GALNT7	51809	broad.mit.edu	37	4	174238873	174238873	+	Missense_Mutation	SNP	G	G	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:174238873G>T	ENST00000265000.4	+	10	1780	c.1697G>T	c.(1696-1698)gGa>gTa	p.G566V		NM_017423.2	NP_059119.2	Q86SF2	GALT7_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)	566	Ricin B-type lectin.				protein O-linked glycosylation	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)|kidney(3)|large_intestine(5)|liver(1)|lung(9)	19		Prostate(90;0.0132)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_hematologic(60;0.107)|all_neural(102;0.122)		all cancers(43;1.87e-18)|Epithelial(43;3.44e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-09)|STAD - Stomach adenocarcinoma(60;0.0019)|GBM - Glioblastoma multiforme(59;0.0119)|LUSC - Lung squamous cell carcinoma(193;0.0199)		CACAGGATGGGAGGGAATCAG	0.413000													12	47					2.27111e-07	2.36786e-07	1	1	0
ABHD10	55347	broad.mit.edu	37	3	111705884	111705884	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:111705884C>G	ENST00000273359.3	+	4	589	c.562C>G	c.(562-564)Cag>Gag	p.Q188E	ABHD10_ENST00000494817.1_Missense_Mutation_p.Q188E|ABHD10_ENST00000534857.1_Missense_Mutation_p.Q31E	NM_018394.2	NP_060864.1	Q9NUJ1	ABHDA_HUMAN	abhydrolase domain containing 10	188						mitochondrion	serine-type peptidase activity			large_intestine(2)|lung(7)|skin(1)	10						AAAGTTTAATCAGCTTCCTGT	0.453000													49	37					0	0	1	0	0
XAGE5	170627	broad.mit.edu	37	X	52844142	52844142	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chrX:52844142G>A	ENST00000351072.1	+	4	271	c.205G>A	c.(205-207)Gag>Aag	p.E69K	XAGE5_ENST00000425386.1_Missense_Mutation_p.E69K|XAGE5_ENST00000445860.2_3'UTR|XAGE5_ENST00000375503.3_3'UTR|XAGE5_ENST00000375501.1_Missense_Mutation_p.E69K			Q8WWM1	GAGD5_HUMAN	X antigen family, member 5	69										endometrium(1)|large_intestine(1)|lung(5)|ovary(1)	8						TGATCTCCAGGAGCTGTCTCA	0.448000													38	1					0	0	1	0	0
PRELP	5549	broad.mit.edu	37	1	203452777	203452777	+	Silent	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:203452777C>G	ENST00000343110.2	+	2	592	c.465C>G	c.(463-465)ctC>ctG	p.L155L		NM_002725.3|NM_201348.1	NP_002716.1|NP_958505.1	P51888	PRELP_HUMAN	proline/arginine-rich end leucine-rich repeat protein	155					skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			BRCA - Breast invasive adenocarcinoma(75;0.109)			TGGTGTTCCTCTACATGGAGA	0.587000													6	168					0	0	1	0	0
PCNXL4	64430	broad.mit.edu	37	14	60581467	60581467	+	Missense_Mutation	SNP	A	A	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr14:60581467A>T	ENST00000406854.1	+	3	1293	c.739A>T	c.(739-741)Atc>Ttc	p.I247F	PCNXL4_ENST00000404681.2_Missense_Mutation_p.I247F|PCNXL4_ENST00000406949.1_Missense_Mutation_p.I13F|PCNXL4_ENST00000317623.4_Missense_Mutation_p.I13F					pecanex-like 4 (Drosophila)																		GATTTTACACATCTTGTTTGT	0.393000													93	23					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152282692	152282692	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:152282692G>A	ENST00000368799.1	-	3	4705	c.4670C>T	c.(4669-4671)tCa>tTa	p.S1557L	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1557	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACGTGACCCTGAGTGCCTGGA	0.602000									Ichthyosis				219	440					0	0	1	0	0
LILRB3	11025	broad.mit.edu	37	19	54720976	54720976	+	Missense_Mutation	SNP	G	G	C	rs142108207	byFrequency	TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:54720976G>C	ENST00000391750.1	-	14	2018	c.1882C>G	c.(1882-1884)Ctg>Gtg	p.L628V	LILRB3_ENST00000346401.6_Missense_Mutation_p.L640V|LILRB3_ENST00000407860.2_Missense_Mutation_p.L645V|LILRA6_ENST00000391735.3_3'UTR|LILRA6_ENST00000419410.2_Missense_Mutation_p.L629V|LILRB3_ENST00000245620.9_Missense_Mutation_p.L629V|LILRB3_ENST00000424807.1_Missense_Mutation_p.L628V|LILRA6_ENST00000440558.2_Missense_Mutation_p.L628V|LILRA6_ENST00000270464.5_Missense_Mutation_p.L629V			O75022	LIRB3_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	628					cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	transmembrane receptor activity			endometrium(3)|kidney(13)|large_intestine(1)|lung(6)|ovary(2)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	34	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TGGATGGCCAGAGTGGCGTAG	0.632000													24	57					0	0	1	0	0
SMC3	9126	broad.mit.edu	37	10	112342324	112342324	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr10:112342324C>G	ENST00000361804.4	+	10	854	c.728C>G	c.(727-729)tCt>tGt	p.S243C		NM_005445.3	NP_005436.1	Q9UQE7	SMC3_HUMAN	structural maintenance of chromosomes 3	243					cell division|DNA mediated transformation|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic spindle organization|negative regulation of DNA endoreduplication|signal transduction|sister chromatid cohesion	basement membrane|chromatin|chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nuclear matrix|nucleoplasm|spindle pole	ATP binding|dynein binding|microtubule motor activity|protein heterodimerization activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(5)|lung(13)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.00206)|all cancers(201;0.0227)|BRCA - Breast invasive adenocarcinoma(275;0.127)		TCTTAGCTTTCTGCTAAGCGA	0.284000													19	23					0	0	1	0	0
HSPA9	3313	broad.mit.edu	37	5	137892240	137892240	+	Silent	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:137892240G>C	ENST00000297185.3	-	16	1988	c.1863C>G	c.(1861-1863)ctC>ctG	p.L621L	HSPA9_ENST00000501917.2_Intron	NM_004134.6	NP_004125.3	P38646	GRP75_HUMAN	heat shock 70kDa protein 9 (mortalin)	621					anti-apoptosis|protein folding	cell surface|mitochondrial nucleoid	ATP binding|unfolded protein binding			breast(2)|endometrium(1)|kidney(4)|large_intestine(8)|lung(12)|upper_aerodigestive_tract(1)	28			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			TTCTAGCCAGGAGCTCCCTCA	0.408000													9	112					0	0	1	0	0
CHAF1A	10036	broad.mit.edu	37	19	4409114	4409114	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:4409114C>T	ENST00000301280.5	+	3	419	c.318C>T	c.(316-318)atC>atT	p.I106I		NM_005483.2	NP_005474	Q13111	CAF1A_HUMAN	chromatin assembly factor 1, subunit A (p150)	106	Binds to CBX1 chromo shadow domain.				cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|WINAC complex	chromatin binding|chromo shadow domain binding|unfolded protein binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	27		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		GAAATAGAATCGAAACCAGTA	0.418000								Chromatin Structure					115	211					0	0	1	0	0
FHDC1	85462	broad.mit.edu	37	4	153896268	153896268	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:153896268G>C	ENST00000511601.1	+	12	2013	c.1825G>C	c.(1825-1827)Gag>Cag	p.E609Q	FHDC1_ENST00000260008.3_Missense_Mutation_p.E609Q			Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	609					actin cytoskeleton organization		actin binding	p.E609K(1)	ARFIP1/FHDC1(2)	NS(2)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	43	all_hematologic(180;0.093)					GGGGGGCCAGGAGGAGGCCCC	0.697000													110	124					0	0	1	0	0
TTC18	118491	broad.mit.edu	37	10	75069932	75069932	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr10:75069932C>G	ENST00000310715.3	-	13	1570	c.1450G>C	c.(1450-1452)Gag>Cag	p.E484Q	TTC18_ENST00000493787.1_5'UTR|TTC18_ENST00000355577.3_5'UTR|TTC18_ENST00000394865.1_Missense_Mutation_p.E484Q|TTC18_ENST00000401621.2_Missense_Mutation_p.E484Q|TTC18_ENST00000340329.3_Intron	NM_145170.3	NP_660153.3	Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	484							binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(2)|prostate(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	Prostate(51;0.0119)					GCTAGCTCCTCTGGCATTCGC	0.388000													8	106					0	0	1	0	0
C17orf47	284083	broad.mit.edu	37	17	56620741	56620741	+	Missense_Mutation	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:56620741C>A	ENST00000321691.3	-	1	988	c.807G>T	c.(805-807)ttG>ttT	p.L269F	RP11-112H10.4_ENST00000578022.1_RNA|RP11-112H10.4_ENST00000580589.1_RNA|RP11-112H10.4_ENST00000580769.1_RNA	NM_001038704.2	NP_001033793	Q8NEP4	CQ047_HUMAN	chromosome 17 open reading frame 47	269										NS(1)|breast(2)|endometrium(1)|kidney(4)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	24	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GCAATGAGTCCAAGTTCATAT	0.453000													36	16					4.11147e-13	4.37992e-13	1	1	0
PIGT	51604	broad.mit.edu	37	20	44048152	44048152	+	Silent	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr20:44048152C>G	ENST00000279036.6	+	5	683	c.603C>G	c.(601-603)ctC>ctG	p.L201L	PIGT_ENST00000372689.5_Silent_p.L201L|PIGT_ENST00000279035.9_Silent_p.L99L|PIGT_ENST00000543458.2_Silent_p.L145L|PIGT_ENST00000535404.1_Silent_p.L46L|PIGT_ENST00000341555.5_Intron|PIGT_ENST00000545755.1_5'UTR	NM_015937.5	NP_057021.2	Q969N2	PIGT_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class T	201					attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			breast(1)|endometrium(2)|kidney(5)|large_intestine(4)|lung(7)|pancreas(1)|skin(1)|stomach(1)	22		Myeloproliferative disorder(115;0.0122)				AGGCAGGCCTCTCTGTGCTGC	0.582000													56	362					0	0	1	0	0
TRMT1	55621	broad.mit.edu	37	19	13227203	13227203	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:13227203G>C	ENST00000592062.1	-	3	581	c.11C>G	c.(10-12)tCg>tGg	p.S4W	TRMT1_ENST00000357720.4_Missense_Mutation_p.S4W|TRMT1_ENST00000592892.1_5'UTR|TRMT1_ENST00000221504.8_Missense_Mutation_p.S4W|TRMT1_ENST00000437766.1_Missense_Mutation_p.S4W			Q9NXH9	TRM1_HUMAN	tRNA methyltransferase 1 homolog (S. cerevisiae)	4							RNA binding|tRNA (guanine-N2-)-methyltransferase activity|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(19;6.08e-22)	GBM - Glioblastoma multiforme(1328;0.0356)		CCACAGAGACGATCCTTGCAT	0.662000													47	36					0	0	1	0	0
SNX6	58533	broad.mit.edu	37	14	35074893	35074893	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr14:35074893C>G	ENST00000362031.4	-	5	367	c.337G>C	c.(337-339)Gat>Cat	p.D113H	SNX6_ENST00000355110.5_5'UTR|SNX6_ENST00000396526.3_5'UTR|SNX6_ENST00000396534.3_5'UTR	NM_152233.2	NP_689419.2	Q9UNH7	SNX6_HUMAN	sorting nexin 6	101	PX.				cell communication|intracellular protein transport|negative regulation of epidermal growth factor receptor activity|negative regulation of transcription, DNA-dependent|negative regulation of transforming growth factor beta receptor signaling pathway|retrograde transport, endosome to Golgi	cytoplasmic vesicle membrane|early endosome membrane|nucleus	phosphatidylinositol binding|protein homodimerization activity			endometrium(4)|lung(1)|ovary(1)	6	Breast(36;0.0473)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00199)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.0245)		CTTGAAGCATCAAAATCAGGT	0.403000													29	11					0	0	1	0	0
GSTM3	2947	broad.mit.edu	37	1	110282104	110282104	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:110282104C>T	ENST00000540225.1	-	4	446	c.136G>A	c.(136-138)Gat>Aat	p.D46N	GSTM3_ENST00000361066.2_Missense_Mutation_p.D46N|GSTM3_ENST00000488824.1_5'UTR|GSTM3_ENST00000256594.3_Missense_Mutation_p.D46N|RP4-735C1.4_ENST00000431955.1_RNA			P21266	GSTM3_HUMAN	glutathione S-transferase mu 3 (brain)	46	GST N-terminal.				establishment of blood-nerve barrier|glutathione metabolic process|response to estrogen stimulus	cytoplasm	glutathione transferase activity|identical protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(2)|skin(1)	9		all_epithelial(167;1.95e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)		Colorectal(144;0.0339)|Lung(183;0.0426)|all cancers(265;0.113)|Epithelial(280;0.125)|COAD - Colon adenocarcinoma(174;0.134)|LUSC - Lung squamous cell carcinoma(189;0.228)	Glutathione(DB00143)	TGGCTTCGATCATAGTCAGGA	0.463000													9	267					0	0	1	0	0
MSL1	339287	broad.mit.edu	37	17	38285590	38285590	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:38285590C>T	ENST00000398532.4	+	3	1400	c.1085C>T	c.(1084-1086)tCt>tTt	p.S362F	MSL1_ENST00000578648.1_Missense_Mutation_p.S362F|MSL1_ENST00000577454.1_Missense_Mutation_p.S362F|MSL1_ENST00000579565.1_Missense_Mutation_p.S99F	NM_001012241.1	NP_001012241.1	Q68DK7	MSL1_HUMAN	male-specific lethal 1 homolog (Drosophila)						histone H4-K16 acetylation	MSL complex				endometrium(1)|kidney(2)|large_intestine(2)|lung(2)	7						CCTAAGCACTCTCCTATTAAA	0.413000													59	60					0	0	1	0	0
SHOX	6473	broad.mit.edu	37	X	601575	601575	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chrX:601575G>A	ENST00000381578.1	+	4	1197	c.506G>A	c.(505-507)aGa>aAa	p.R169K	SHOX_ENST00000381575.1_Missense_Mutation_p.R169K|SHOX_ENST00000334060.3_Missense_Mutation_p.R169K|SHOX_ENST00000554971.1_Missense_Mutation_p.R169K	NM_000451.3	NP_000442.1	O15266	SHOX_HUMAN	short stature homeobox	169					skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|lung(9)|prostate(1)	13		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CAGAACCGGAGAGCCAAGTGC	0.597000													50	79					0	0	1	0	0
ATP6V1G3	127124	broad.mit.edu	37	1	198505825	198505825	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:198505825C>G	ENST00000309309.7	-	3	217	c.112G>C	c.(112-114)Gac>Cac	p.D38H	ATP6V1G3_ENST00000281087.2_Intron|ATP6V1G3_ENST00000489986.1_Splice_Site_p.K28N|ATP6V1G3_ENST00000367381.1_Splice_Site_p.K28N|ATP6V1G3_ENST00000367382.1_Intron	NM_133326.1	NP_579872.1	Q96LB4	VATG3_HUMAN	ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3	0					cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|plasma membrane|vacuolar proton-transporting V-type ATPase complex	ATPase binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(3)|prostate(1)	7						CAGTCCCAGTCTCTTCGTTTT	0.333000													65	215					0	0	1	0	0
BTNL2	56244	broad.mit.edu	37	6	32363975	32363975	+	Nonsense_Mutation	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:32363975C>A	ENST00000454136.3	-	5	923	c.919G>T	c.(919-921)Gag>Tag	p.E307*	BTNL2_ENST00000374993.1_Nonsense_Mutation_p.E307*|BTNL2_ENST00000544175.1_Nonsense_Mutation_p.E30*|BTNL2_ENST00000540315.1_Nonsense_Mutation_p.E97*|BTNL2_ENST00000414363.1_Nonsense_Mutation_p.E97*|BTNL2_ENST00000429232.2_Nonsense_Mutation_p.E214*|BTNL2_ENST00000374995.3_Nonsense_Mutation_p.E213*			Q9UIR0	BTNL2_HUMAN	butyrophilin-like 2 (MHC class II associated)	307	Ig-like V-type 3.					integral to membrane				central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|prostate(1)|urinary_tract(1)	19						CCTCTGTACTCTGCCATCTGC	0.582000													11	28					3.86212e-05	3.93403e-05	1	1	0
ADAMTS10	81794	broad.mit.edu	37	19	8651502	8651502	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:8651502C>T	ENST00000270328.4	-	19	2609	c.2343G>A	c.(2341-2343)ggG>ggA	p.G781G	ADAMTS10_ENST00000597188.1_Silent_p.G781G|ADAMTS10_ENST00000595838.1_Silent_p.G268G			Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 10	781	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(16)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(3)|skin(10)|urinary_tract(1)	53						CCTGGTCTGGCCCCTGTCGCA	0.617000											OREG0025221	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	119					0	0	1	0	0
ACSS3	79611	broad.mit.edu	37	12	81503365	81503365	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:81503365G>A	ENST00000548058.1	+	2	1248	c.338G>A	c.(337-339)tGt>tAt	p.C113Y	RP11-543H12.1_ENST00000547123.1_RNA|ACSS3_ENST00000261206.3_Missense_Mutation_p.C112Y			Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	113						mitochondrion	acetate-CoA ligase activity|ATP binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(7)|liver(3)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	51						CTTAACATTTGTTACAATGCC	0.313000													27	20					0	0	1	0	0
SERPINB6	5269	broad.mit.edu	37	6	2959519	2959519	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:2959519C>T	ENST00000380520.1	-	1	2042	c.48G>A	c.(46-48)ttG>ttA	p.L16L	SERPINB6_ENST00000380524.1_Silent_p.L16L|SERPINB6_ENST00000380539.1_Silent_p.L16L|SERPINB6_ENST00000380546.3_Silent_p.L16L|SERPINB6_ENST00000335686.5_Silent_p.L16L|SERPINB6_ENST00000380529.1_Silent_p.L16L			P35237	SPB6_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 6	16					regulation of proteolysis	centrosome|cytosol|protein complex	protease binding|serine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(8)|stomach(1)|upper_aerodigestive_tract(2)	17	Ovarian(93;0.0412)	all_hematologic(90;0.0895)			Drotrecogin alfa(DB00055)	CCAGCGTTTTCAAAAGGTTTA	0.468000													5	113					0	0	1	0	0
TP53INP1	94241	broad.mit.edu	37	8	95952279	95952279	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr8:95952279C>G	ENST00000342697.4	-	3	689	c.282G>C	c.(280-282)gaG>gaC	p.E94D	TP53INP1_ENST00000448464.2_Missense_Mutation_p.E94D|TP53INP1_ENST00000378776.4_Missense_Mutation_p.E94D|NDUFAF6_ENST00000396113.1_Intron	NM_033285.3	NP_150601.1	Q96A56	T53I1_HUMAN	tumor protein p53 inducible nuclear protein 1	94					apoptosis	PML body				kidney(2)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	9	Breast(36;8.75e-07)					TAAACCAGCTCTCCTCCATTG	0.463000													70	35					0	0	1	0	0
SSH2	85464	broad.mit.edu	37	17	27999017	27999017	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:27999017C>T	ENST00000269033.3	-	8	815	c.664G>A	c.(664-666)Gaa>Aaa	p.E222K	RP11-68I3.2_ENST00000581474.1_RNA|SSH2_ENST00000540801.1_Missense_Mutation_p.E249K	NM_001282129.1|NM_033389.2	NP_001269058.1|NP_203747.2	Q76I76	SSH2_HUMAN	slingshot protein phosphatase 2	222					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity		SSH2/SUZ12(2)	breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GCATTCCATTCATTGACTGAG	0.468000													17	188					0	0	1	0	0
NEK7	140609	broad.mit.edu	37	1	198233300	198233300	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:198233300G>A	ENST00000367385.4	+	5	649	c.307G>A	c.(307-309)Gaa>Aaa	p.E103K	NEK7_ENST00000538004.1_Missense_Mutation_p.E103K	NM_133494.2	NP_598001.1	Q8TDX7	NEK7_HUMAN	NIMA-related kinase 7	103	Protein kinase.					cytoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			endometrium(3)|kidney(2)|large_intestine(5)|lung(2)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	21						ATCATTCATTGAAGATAATGA	0.313000													5	101					0	0	1	0	0
CD163L1	283316	broad.mit.edu	37	12	7528192	7528192	+	Splice_Site	SNP	C	C	T	rs138525217		TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:7528192C>T	ENST00000313599.3	-	11	2744		c.e11-1		CD163L1_ENST00000396630.1_Splice_Site|CD163L1_ENST00000544331.1_Splice_Site|CD163L1_ENST00000416109.2_Splice_Site			Q9NR16	C163B_HUMAN	CD163 molecule-like 1							extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						TCTGTATATCCTAGGAGGAGA	0.488000													29	16					0	0	1	0	0
SMPDL3A	10924	broad.mit.edu	37	6	123124903	123124903	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:123124903G>A	ENST00000368440.4	+	5	840	c.663G>A	c.(661-663)ctG>ctA	p.L221L	SMPDL3A_ENST00000539041.1_Silent_p.L90L	NM_006714.3	NP_006705.1	Q92484	ASM3A_HUMAN	sphingomyelin phosphodiesterase, acid-like 3A	221					sphingomyelin catabolic process	extracellular space	hydrolase activity, acting on glycosyl bonds|protein binding|sphingomyelin phosphodiesterase activity			breast(1)|cervix(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|urinary_tract(1)	10				GBM - Glioblastoma multiforme(226;0.236)		TAATGACACTGAACAAGACTG	0.388000													73	54					0	0	1	0	0
SLC44A3	126969	broad.mit.edu	37	1	95290163	95290163	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:95290163C>G	ENST00000271227.6	+	3	352	c.250C>G	c.(250-252)Ctt>Gtt	p.L84V	SLC44A3_ENST00000529450.1_Missense_Mutation_p.L84V|SLC44A3_ENST00000532427.1_Missense_Mutation_p.L36V|SLC44A3_ENST00000527077.1_Missense_Mutation_p.L48V|SLC44A3_ENST00000446120.2_Missense_Mutation_p.L48V|SLC44A3_ENST00000467909.1_Missense_Mutation_p.L36V	NM_001114106.2|NM_001258340.1|NM_001258341.1	NP_001107578.1|NP_001245269.1|NP_001245270.1	Q8N4M1	CTL3_HUMAN	solute carrier family 44, member 3	84						integral to membrane|plasma membrane	choline transmembrane transporter activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(6)|prostate(2)|stomach(1)|urinary_tract(1)	23		all_lung(203;0.000712)|Lung NSC(277;0.00316)		all cancers(265;0.039)|Epithelial(280;0.124)	Choline(DB00122)	AGGGGCCCCTCTTTCAGGGCA	0.483000													26	90					0	0	1	0	0
ALDH1A2	8854	broad.mit.edu	37	15	58306123	58306123	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr15:58306123G>C	ENST00000249750.4	-	3	1063	c.296C>G	c.(295-297)gCt>gGt	p.A99G	ALDH1A2_ENST00000537372.1_Missense_Mutation_p.A78G|ALDH1A2_ENST00000559517.1_Missense_Mutation_p.A3G|ALDH1A2_ENST00000558231.1_Missense_Mutation_p.A70G|ALDH1A2_ENST00000347587.3_Missense_Mutation_p.A99G	NM_003888.3	NP_003879.2	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1 family, member A2	99					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(15)|prostate(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	CCTTTCTGAAGCATCCATCCT	0.483000													10	361					0	0	1	0	0
RGS12	6002	broad.mit.edu	37	4	3430382	3430382	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:3430382C>T	ENST00000336727.3	+	16	4413	c.3509C>T	c.(3508-3510)tCt>tTt	p.S1170F	RGS12_ENST00000338806.4_Missense_Mutation_p.S522F|RGS12_ENST00000538395.1_Intron|RGS12_ENST00000382788.3_Missense_Mutation_p.S1170F|RGS12_ENST00000306648.7_Intron|RGS12_ENST00000344733.5_Missense_Mutation_p.S1170F	NM_002926.3	NP_002917.1	O14924	RGS12_HUMAN	regulator of G-protein signaling 12	1170						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			autonomic_ganglia(1)|breast(4)|endometrium(3)|kidney(2)|large_intestine(9)|lung(16)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		AGAGAAGAATCTATTGCAAAG	0.343000													45	44					0	0	1	0	0
ZNF37BP	100129482	broad.mit.edu	37	10	43015727	43015727	+	RNA	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr10:43015727G>A	ENST00000452075.3	-	0	1867					NR_026777.1																						TGACTTAAACGAGGTTTTCCC	0.423000													6	16					0	0	1	0	0
BCL2L13	23786	broad.mit.edu	37	22	18210208	18210208	+	Nonsense_Mutation	SNP	G	G	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr22:18210208G>T	ENST00000317582.5	+	7	1713	c.1366G>T	c.(1366-1368)Gag>Tag	p.E456*	BCL2L13_ENST00000538149.1_Nonsense_Mutation_p.E332*|BCL2L13_ENST00000485631.1_3'UTR|BCL2L13_ENST00000355028.3_3'UTR|BCL2L13_ENST00000337612.5_Nonsense_Mutation_p.E294*|BCL2L13_ENST00000418951.2_3'UTR|BCL2L13_ENST00000543133.1_Nonsense_Mutation_p.E294*	NM_015367.3	NP_056182.2	Q9BXK5	B2L13_HUMAN	BCL2-like 13 (apoptosis facilitator)	456					induction of apoptosis	integral to membrane|mitochondrial membrane|nucleus	caspase activator activity			breast(2)|central_nervous_system(1)|large_intestine(2)|liver(2)|lung(2)|ovary(1)|skin(3)|urinary_tract(2)	15		all_epithelial(15;0.123)		Lung(27;0.199)		GCCGCTGTCTGAGGGCAAGTC	0.607000													48	95					1.30916e-28	1.41737e-28	1	1	0
SCAF1	58506	broad.mit.edu	37	19	50154724	50154724	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:50154724G>A	ENST00000360565.3	+	7	1202	c.1078G>A	c.(1078-1080)Gag>Aag	p.E360K		NM_021228.2	NP_067051.2	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	360					mRNA processing|RNA splicing	nucleus	RNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	20		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		GACCGAGGCAGAGGCTTGTCG	0.726000													9	4					0	0	1	0	0
AFAP1L2	84632	broad.mit.edu	37	10	116061127	116061127	+	Nonsense_Mutation	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr10:116061127C>A	ENST00000369271.3	-	13	1828	c.1528G>T	c.(1528-1530)Gag>Tag	p.E510*	AFAP1L2_ENST00000491814.1_5'UTR|AFAP1L2_ENST00000545353.1_Nonsense_Mutation_p.E563*|AFAP1L2_ENST00000304129.4_Nonsense_Mutation_p.E510*	NM_001001936.1|NM_032550.2	NP_001001936.1|NP_115939.1	Q8N4X5	AF1L2_HUMAN	actin filament associated protein 1-like 2	510					inflammatory response|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of transcription, DNA-dependent|regulation of interleukin-6 production|regulation of mitotic cell cycle	cytoplasm	protein tyrosine kinase activator activity|SH2 domain binding|SH3 domain binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|prostate(2)	21		Colorectal(252;0.175)|Breast(234;0.231)		Epithelial(162;0.0219)|all cancers(201;0.0561)		GCTGTGAGCTCTGACAGGTCC	0.592000													4	45					0.00024832	0.000251019	1	1	0
ARMC8	25852	broad.mit.edu	37	3	137956400	137956400	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:137956400C>T	ENST00000469044.1	+	9	1033	c.762C>T	c.(760-762)ctC>ctT	p.L254L	ARMC8_ENST00000470821.1_Silent_p.L254L|ARMC8_ENST00000489213.1_Silent_p.L212L|ARMC8_ENST00000485396.1_Silent_p.L181L|ARMC8_ENST00000461822.1_Silent_p.L254L|ARMC8_ENST00000491704.1_Silent_p.L212L|ARMC8_ENST00000393058.3_Silent_p.L244L|ARMC8_ENST00000481646.1_Silent_p.L240L|ARMC8_ENST00000538260.1_Silent_p.L223L|ARMC8_ENST00000358441.2_Silent_p.L240L|ARMC8_ENST00000471453.1_Silent_p.L240L	NM_001267041.1|NM_001267042.1	NP_001253970.1|NP_001253971.1	Q8IUR7	ARMC8_HUMAN	armadillo repeat containing 8	254							binding			endometrium(2)|kidney(1)|large_intestine(7)|lung(5)|upper_aerodigestive_tract(1)	16						AGATGCAGCTCACATCAGCAA	0.358000													26	24					0	0	1	0	0
PRTG	283659	broad.mit.edu	37	15	55972329	55972329	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr15:55972329G>A	ENST00000389286.4	-	6	943	c.896C>T	c.(895-897)gCt>gTt	p.A299V		NM_173814.4	NP_776175.2	Q2VWP7	PRTG_HUMAN	protogenin	299	Ig-like 3.				multicellular organismal development	integral to membrane				breast(1)|endometrium(6)|kidney(4)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	41				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		ATATACTCCAGCATGTTGTAG	0.393000													9	25					0	0	1	0	0
SRRM4	84530	broad.mit.edu	37	12	119583487	119583487	+	Nonsense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:119583487C>G	ENST00000267260.4	+	9	1461	c.1073C>G	c.(1072-1074)tCa>tGa	p.S358*		NM_194286.3	NP_919262.2	A7MD48	SRRM4_HUMAN	serine/arginine repetitive matrix 4	358	Ser-rich.				cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	24						GGCAGAGAGTCAAGGTCAGTG	0.602000													7	13					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98563429	98563429	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:98563429G>A	ENST00000359863.4	+	48	7275	c.7066G>A	c.(7066-7068)Gaa>Aaa	p.E2356K	TRRAP_ENST00000446306.3_Missense_Mutation_p.E2338K|TRRAP_ENST00000355540.3_Missense_Mutation_p.E2338K	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	2356	Interaction with TP53.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			ATCCCTCATCGAAAAATCACC	0.532000													44	39					0	0	1	0	0
NAP1L1	4673	broad.mit.edu	37	12	76453941	76453941	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:76453941G>C	ENST00000261182.8	-	5	811	c.325C>G	c.(325-327)Ctc>Gtc	p.L109V	NAP1L1_ENST00000549596.1_Missense_Mutation_p.L109V|NAP1L1_ENST00000535020.2_Missense_Mutation_p.L109V|NAP1L1_ENST00000547773.1_Missense_Mutation_p.L46V|NAP1L1_ENST00000548044.1_Missense_Mutation_p.L68V|NAP1L1_ENST00000542344.1_Missense_Mutation_p.L68V|NAP1L1_ENST00000552342.1_Missense_Mutation_p.L109V|NAP1L1_ENST00000431879.3_Missense_Mutation_p.L68V|NAP1L1_ENST00000393263.3_Missense_Mutation_p.L109V|NAP1L1_ENST00000544816.1_5'UTR	NM_004537.4|NM_139207.2	NP_004528.1|NP_631946.1	P55209	NP1L1_HUMAN	nucleosome assembly protein 1-like 1	109					DNA replication|nucleosome assembly|positive regulation of cell proliferation	chromatin assembly complex|melanosome	protein binding			kidney(1)|large_intestine(1)|lung(3)|ovary(2)|prostate(1)|skin(1)	9		Colorectal(145;0.09)				GGCTGATAGAGAACAGCATAC	0.368000													15	61					0	0	1	0	0
NAA40	79829	broad.mit.edu	37	11	63719941	63719941	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:63719941G>A	ENST00000377793.4	+	5	415	c.314G>A	c.(313-315)cGa>cAa	p.R105Q	NAA40_ENST00000536939.1_3'UTR|NAA40_ENST00000542163.1_Missense_Mutation_p.R84Q|NAA40_ENST00000539656.1_Intron|NAA40_ENST00000456907.2_Missense_Mutation_p.R65Q	NM_024771.2	NP_079047.2	Q86UY6	NAA40_HUMAN	N(alpha)-acetyltransferase 40, NatD catalytic subunit	105	N-acetyltransferase.						N-acetyltransferase activity			NS(1)|endometrium(1)|lung(2)|prostate(1)	5						ACAGATGACCGAGCCTGGTAC	0.562000													54	52					0	0	1	0	0
KPNA5	3841	broad.mit.edu	37	6	117045483	117045483	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:117045483C>T	ENST00000368564.1	+	10	1092	c.944C>T	c.(943-945)tCa>tTa	p.S315L	KPNA5_ENST00000356348.1_Missense_Mutation_p.S315L			O15131	IMA5_HUMAN	karyopherin alpha 5 (importin alpha 6)	312					NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding|protein transporter activity			breast(6)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0298)|all cancers(137;0.0461)|OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.212)		AAAGTTGTATCACCTGCATTA	0.284000													9	24					0	0	1	0	0
STX1A	6804	broad.mit.edu	37	7	73117244	73117244	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:73117244G>C	ENST00000222812.3	-	8	635	c.609C>G	c.(607-609)atC>atG	p.I203M	STX1A_ENST00000395155.3_Missense_Mutation_p.I203M|STX1A_ENST00000395154.3_Missense_Mutation_p.I203M|STX1A_ENST00000395156.3_Missense_Mutation_p.I203M|WBSCR22_ENST00000423166.2_Intron	NM_004603.3	NP_004594.1	Q16623	STX1A_HUMAN	syntaxin 1A (brain)	203	t-SNARE coiled-coil homology.				energy reserve metabolic process|glutamate secretion|intracellular protein transport|regulation of insulin secretion	cell junction|extracellular region|integral to membrane|neuron projection|synaptic vesicle membrane|synaptosome	SNAP receptor activity			large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	5		Lung NSC(55;0.0908)|all_lung(88;0.198)				TCTCCAGCTTGATGATCTCAC	0.612000													23	50					0	0	1	0	0
THEMIS2	9473	broad.mit.edu	37	1	28209310	28209310	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:28209310C>G	ENST00000373921.3	+	4	1479	c.1475C>G	c.(1474-1476)tCt>tGt	p.S492C	THEMIS2_ENST00000373927.3_Intron|THEMIS2_ENST00000328928.7_Missense_Mutation_p.S363C|THEMIS2_ENST00000373925.1_Intron	NM_001105556.1	NP_001099026.1			thymocyte selection associated family member 2																		AGCCTAGACTCTGAGCCTGGG	0.612000													6	192					0	0	1	0	0
FAM53A	152877	broad.mit.edu	37	4	1643153	1643153	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:1643153G>C	ENST00000308132.6	-	5	1256	c.1064C>G	c.(1063-1065)tCt>tGt	p.S355C	FAM53A_ENST00000489363.1_3'UTR|FAM53A_ENST00000472884.2_Missense_Mutation_p.S355C|FAM53A_ENST00000461064.1_Missense_Mutation_p.S355C	NM_001174070.1	NP_001167541.1	Q6NSI3	FA53A_HUMAN	family with sequence similarity 53, member A	355						nucleus				breast(2)|central_nervous_system(2)|large_intestine(1)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10		all_epithelial(65;0.206)|Breast(71;0.212)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)			CGACTCCCTAGAGGCCCACAG	0.706000													7	183					0	0	1	0	0
CTNND1	1500	broad.mit.edu	37	11	57583408	57583408	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:57583408C>G	ENST00000399050.4	+	20	3366	c.2830C>G	c.(2830-2832)Ctg>Gtg	p.L944V	CTNND1_ENST00000530748.1_Intron|CTNND1_ENST00000532245.1_Intron|CTNND1_ENST00000525902.1_Intron|CTNND1_ENST00000532649.1_Intron|CTNND1_ENST00000526772.1_Intron|CTNND1_ENST00000528621.1_Intron|CTNND1_ENST00000534579.1_Intron|CTNND1_ENST00000426142.2_Intron|CTNND1_ENST00000526938.1_Intron|CTNND1_ENST00000529986.1_Intron|CTNND1_ENST00000528232.1_Intron|CTNND1_ENST00000532844.1_Missense_Mutation_p.L890V|CTNND1_ENST00000361796.4_Intron|CTNND1_ENST00000529873.1_Missense_Mutation_p.L863V|CTNND1_ENST00000358694.6_Intron|CTNND1_ENST00000532463.1_Intron|CTNND1_ENST00000530094.1_Missense_Mutation_p.L837V|CTNND1_ENST00000527467.1_Missense_Mutation_p.L621V|CTNND1_ENST00000524630.1_Intron|CTNND1_ENST00000529919.1_Intron|CTNND1_ENST00000361391.6_Missense_Mutation_p.L917V|CTNND1_ENST00000529526.1_Intron|CTNND1_ENST00000399039.4_Intron|CTNND1_ENST00000531014.1_Missense_Mutation_p.L615V|CTNND1_ENST00000428599.2_Intron|CTNND1_ENST00000532787.1_Missense_Mutation_p.L816V|CTNND1_ENST00000526357.1_Missense_Mutation_p.L884V|CTNND1_ENST00000533667.1_Missense_Mutation_p.L594V|CTNND1_ENST00000361332.4_Missense_Mutation_p.L938V|CTNND1_ENST00000360682.6_Missense_Mutation_p.L923V|CTNND1_ENST00000415361.2_Missense_Mutation_p.L843V	NM_001085458.1	NP_001078927.1	O60716	CTND1_HUMAN	catenin (cadherin-associated protein), delta 1	944					adherens junction organization|cell junction assembly|negative regulation of canonical Wnt receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytosol|midbody|nucleus	cadherin binding|protein binding|receptor binding			breast(5)|endometrium(8)|kidney(4)|large_intestine(7)|liver(2)|lung(16)|ovary(1)|upper_aerodigestive_tract(2)	45		all_epithelial(135;0.155)				GCAGGAATCTCTGGAGGAAGA	0.493000													11	12					0	0	1	0	0
ENOSF1	55556	broad.mit.edu	37	18	683378	683378	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr18:683378C>T	ENST00000319815.6	-	3	1318	c.54G>A	c.(52-54)atG>atA	p.M18I	ENOSF1_ENST00000251101.7_Missense_Mutation_p.M248I|ENOSF1_ENST00000340116.7_Missense_Mutation_p.M269I|ENOSF1_ENST00000580982.1_Missense_Mutation_p.M172I|ENOSF1_ENST00000383578.3_Missense_Mutation_p.M166I|ENOSF1_ENST00000583973.1_5'UTR			Q7L5Y1	ENOF1_HUMAN	enolase superfamily member 1	248					cellular amino acid catabolic process	mitochondrion	isomerase activity|metal ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)	10						TGGCATCCATCATCTGCAAAA	0.587000													21	57					0	0	1	0	0
EPHB6	2051	broad.mit.edu	37	7	142566046	142566046	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:142566046C>G	ENST00000392957.2	+	14	2753	c.1966C>G	c.(1966-1968)Cag>Gag	p.Q656E	EPHB6_ENST00000411471.2_Missense_Mutation_p.Q379E|EPHB6_ENST00000442129.1_Missense_Mutation_p.Q656E	NM_004445.3	NP_004436.3	O15197	EPHB6_HUMAN	EPH receptor B6	656						extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					GGACCCCTGTCAGGCCATCCG	0.562000													55	25					0	0	1	0	0
ZFY	7544	broad.mit.edu	37	Y	2844836	2844836	+	Missense_Mutation	SNP	G	G	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chrY:2844836G>T	ENST00000155093.3	+	6	1375	c.1054G>T	c.(1054-1056)Gta>Tta	p.V352L	ZFY_ENST00000383052.1_Missense_Mutation_p.V352L|ZFY_ENST00000431102.1_Missense_Mutation_p.V161L|ZFY-AS1_ENST00000417305.1_RNA|ZFY_ENST00000449237.1_Intron	NM_003411.3	NP_003402.2	P08048	ZFY_HUMAN	zinc finger protein, Y-linked	352					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			biliary_tract(1)|kidney(3)|large_intestine(1)|lung(3)	8						GAAAACCTTCGTACCAATTGC	0.428000													13	31					1.5842e-08	1.66475e-08	1	1	0
SYNE1	23345	broad.mit.edu	37	6	152565761	152565761	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:152565761C>G	ENST00000367255.5	-	106	20204	c.19603G>C	c.(19603-19605)Gaa>Caa	p.E6535Q	SYNE1_ENST00000448038.1_Missense_Mutation_p.E6464Q|SYNE1_ENST00000341594.5_Missense_Mutation_p.E6147Q|SYNE1_ENST00000423061.1_Missense_Mutation_p.E6464Q|SYNE1_ENST00000356820.4_Missense_Mutation_p.E1059Q|SYNE1_ENST00000265368.4_Missense_Mutation_p.E6535Q	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6535					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GCATCAAATTCTTTGAGTCCA	0.438000										HNSCC(10;0.0054)			52	39					0	0	1	0	0
BUD31	8896	broad.mit.edu	37	7	99013831	99013831	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:99013831G>C	ENST00000403633.2	+	4	694	c.165G>C	c.(163-165)caG>caC	p.Q55H	BUD31_ENST00000431419.1_Missense_Mutation_p.Q26H|BUD31_ENST00000222969.5_Missense_Mutation_p.Q55H|BUD31_ENST00000456893.1_Intron			P41223	BUD31_HUMAN	BUD31 homolog (S. cerevisiae)	55					regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity			autonomic_ganglia(1)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|ovary(1)	4	all_cancers(62;1.76e-08)|all_epithelial(64;1.63e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			TCCACCACCAGAAAACCCGCT	0.493000													24	125					0	0	1	0	0
TTC7A	57217	broad.mit.edu	37	2	47300852	47300852	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:47300852G>A	ENST00000319190.5	+	20	2735	c.2367G>A	c.(2365-2367)ctG>ctA	p.L789L	RP11-761B3.1_ENST00000422269.1_Intron|TTC7A_ENST00000409245.1_Silent_p.L755L|C2orf61_ENST00000464527.2_Intron|TTC7A_ENST00000394850.2_Silent_p.L813L|TTC7A_ENST00000263737.6_Silent_p.L435L	NM_020458.2	NP_065191.2	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	789							binding			breast(4)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			GTCTGATGCTGAGTCGGCTGG	0.652000													46	45					0	0	1	0	0
CCDC62	84660	broad.mit.edu	37	12	123265785	123265785	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:123265785G>C	ENST00000253079.6	+	3	648	c.304G>C	c.(304-306)Gaa>Caa	p.E102Q	CCDC62_ENST00000392441.4_Missense_Mutation_p.E102Q|CCDC62_ENST00000537566.1_5'UTR	NM_201435.4	NP_958843.2	Q6P9F0	CCD62_HUMAN	coiled-coil domain containing 62	102						cytoplasm|nucleus				breast(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(1)	20	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.51e-06)|Epithelial(86;2.65e-05)|BRCA - Breast invasive adenocarcinoma(302;0.206)		CAATCAAATGGAATGCCAAAC	0.408000													5	104					0	0	1	0	0
ATP8A1	10396	broad.mit.edu	37	4	42466732	42466732	+	Missense_Mutation	SNP	T	T	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:42466732T>C	ENST00000381668.5	-	27	2825	c.2594A>G	c.(2593-2595)aAg>aGg	p.K865R	ATP8A1_ENST00000264449.10_Missense_Mutation_p.K850R	NM_006095.2	NP_006086.1	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	865					ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	51					Phosphatidylserine(DB00144)	CACTATATTCTTGTAGAAGCA	0.313000													42	46					0	0	1	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90161902	90161902	+	RNA	SNP	A	A	G	rs6500471	by1000genomes	TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr16:90161902A>G	ENST00000567960.1	+	0	638				TUBB8P7_ENST00000564451.1_RNA														p.K213R(8)									ATATGTTCCAAGACCCTAAAA	0.537000													5	38					0	0	1	0	0
BDP1	55814	broad.mit.edu	37	5	70808128	70808128	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:70808128G>A	ENST00000358731.4	+	18	4383	c.4120G>A	c.(4120-4122)Gaa>Aaa	p.E1374K	BDP1_ENST00000380675.2_5'UTR	NM_018429.2	NP_060899.2	A6H8Y1	BDP1_HUMAN	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	1374					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding	p.E1374Q(1)		NS(2)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(34)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		AAGAAATTCTGAAAAAGAAGT	0.363000													58	35					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77618659	77618659	+	Missense_Mutation	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr8:77618659C>A	ENST00000521891.2	+	2	2784	c.2336C>A	c.(2335-2337)gCc>gAc	p.A779D	ZFHX4_ENST00000455469.2_Missense_Mutation_p.A779D|ZFHX4_ENST00000517683.1_Intron|ZFHX4_ENST00000518282.1_Missense_Mutation_p.A779D|ZFHX4_ENST00000050961.6_Missense_Mutation_p.A779D	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	779						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ACCAATGTCGCCAGGAACCTC	0.498000										HNSCC(33;0.089)			21	40					2.27731e-05	2.3248e-05	1	1	0
DMXL2	23312	broad.mit.edu	37	15	51749644	51749644	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr15:51749644G>A	ENST00000251076.5	-	36	8439	c.8152C>T	c.(8152-8154)Cgt>Tgt	p.R2718C	DMXL2_ENST00000449909.3_Missense_Mutation_p.R2082C|RP11-707P17.1_ENST00000561007.1_RNA|DMXL2_ENST00000543779.2_Missense_Mutation_p.R2719C|RP11-707P17.2_ENST00000559977.1_RNA	NM_001174116.1|NM_015263.3	NP_001167587.1|NP_056078.2	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	2718						cell junction|synaptic vesicle membrane	Rab GTPase binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(26)|liver(1)|lung(28)|ovary(7)|prostate(7)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	101				all cancers(107;0.00494)		GTGGAACCACGATAATCAACA	0.413000													50	41					0	0	1	0	0
KRT84	3890	broad.mit.edu	37	12	52778880	52778880	+	Missense_Mutation	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:52778880C>A	ENST00000257951.3	-	1	556	c.490G>T	c.(490-492)Gat>Tat	p.D164Y	RP3-416H24.4_ENST00000547174.1_RNA	NM_033045.3	NP_149034.2	Q9NSB2	KRT84_HUMAN	keratin 84	164	Head.					keratin filament	structural constituent of epidermis			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(1)|lung(10)|skin(3)	27	all_hematologic(5;0.12)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TCCTTCTCATCCTTCTTCACC	0.498000													131	123					1.30882e-70	1.44048e-70	1	1	0
GBX2	2637	broad.mit.edu	37	2	237075028	237075028	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:237075028C>T	ENST00000551105.1	-	3	650	c.613G>A	c.(613-615)Gaa>Aaa	p.E205K	GBX2_ENST00000306318.4_Silent_p.P192P|GBX2_ENST00000465889.1_5'UTR			P52951	GBX2_HUMAN	gastrulation brain homeobox 2	0						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)	7		Breast(86;0.00235)|Renal(207;0.00339)|all_hematologic(139;0.00357)|all_lung(227;0.0616)|Acute lymphoblastic leukemia(138;0.0775)|Ovarian(221;0.089)|Lung NSC(271;0.179)		Epithelial(121;4.5e-25)|OV - Ovarian serous cystadenocarcinoma(60;5.16e-11)|BRCA - Breast invasive adenocarcinoma(100;3.4e-05)|Lung(119;0.00195)|LUSC - Lung squamous cell carcinoma(224;0.00471)		CCTTGCCCTTCGGGTCGTCTT	0.562000													71	57					0	0	1	0	0
NKAPL	222698	broad.mit.edu	37	6	28227895	28227895	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:28227895G>A	ENST00000343684.3	+	1	798	c.746G>A	c.(745-747)aGt>aAt	p.S249N		NM_001007531.1	NP_001007532.1	Q5M9Q1	NKAPL_HUMAN	NFKB activating protein-like	249										breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	31						AAAGAATCCAGTGACTCAAGC	0.368000													7	7					0	0	1	0	0
ATMIN	23300	broad.mit.edu	37	16	81076969	81076969	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr16:81076969G>C	ENST00000566488.1	+	3	1361	c.398G>C	c.(397-399)aGa>aCa	p.R133T	ATMIN_ENST00000564241.1_Missense_Mutation_p.R133T|ATMIN_ENST00000539819.1_3'UTR|ATMIN_ENST00000299575.4_Missense_Mutation_p.R289T			O43313	ATMIN_HUMAN	ATM interactor	289					response to DNA damage stimulus	nucleus	zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	20						ACACCACCGAGATATCCTCAG	0.443000													42	94					0	0	1	0	0
STK31	56164	broad.mit.edu	37	7	23871969	23871969	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:23871969C>G	ENST00000354639.3	+	24	3439	c.2975C>G	c.(2974-2976)gCc>gGc	p.A992G	STK31_ENST00000433467.2_Missense_Mutation_p.A992G|STK31_ENST00000355870.3_Missense_Mutation_p.A1015G|STK31_ENST00000428484.1_Missense_Mutation_p.A992G|STK31_ENST00000405627.3_3'UTR	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	1015	Protein kinase.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						AATGGTGAAGCCAACTTTGAT	0.318000													16	47					0	0	1	0	0
NTM	50863	broad.mit.edu	37	11	132184556	132184556	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:132184556C>G	ENST00000374786.1	+	6	1372	c.893C>G	c.(892-894)tCc>tGc	p.S298C	NTM_ENST00000427481.2_Missense_Mutation_p.S289C|NTM_ENST00000374791.3_Missense_Mutation_p.S298C|NTM_ENST00000474900.1_3'UTR|NTM_ENST00000374784.1_Missense_Mutation_p.S298C|NTM_ENST00000425719.2_Missense_Mutation_p.S298C|NTM_ENST00000539799.1_Missense_Mutation_p.S298C	NM_001144058.1|NM_016522.2	NP_001137530.1|NP_057606.1	Q9P121	NTRI_HUMAN	neurotrimin	298	Ig-like C2-type 3.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(9)|lung(30)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	56						TGCGTGGCCTCCAACAAGCTG	0.507000													31	24					0	0	1	0	0
EIF2AK4	440275	broad.mit.edu	37	15	40268702	40268702	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr15:40268702G>A	ENST00000263791.5	+	12	1949	c.1906G>A	c.(1906-1908)Gaa>Aaa	p.E636K	EIF2AK4_ENST00000382727.2_Missense_Mutation_p.E636K	NM_001013703.2	NP_001013725.2	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha kinase 4	636	Protein kinase 2.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)	40		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		GATCAAGGGCGAAGTGACACT	0.657000													13	29					0	0	1	0	0
PCDH9	5101	broad.mit.edu	37	13	67800923	67800923	+	Silent	SNP	A	A	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr13:67800923A>T	ENST00000544246.1	-	2	2341	c.1650T>A	c.(1648-1650)ccT>ccA	p.P550P	PCDH9_ENST00000377865.2_Silent_p.P550P|PCDH9_ENST00000456367.1_Silent_p.P550P|PCDH9_ENST00000328454.5_Silent_p.P550P|PCDH9_ENST00000377861.3_Silent_p.P550P	NM_203487.2	NP_982354.1	Q9HC56	PCDH9_HUMAN	protocadherin 9	550	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(33)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	103		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		TTTGGAGGGGAGGGGTCCCAT	0.428000													25	108					0	0	1	0	0
GPR158	57512	broad.mit.edu	37	10	25888018	25888018	+	Missense_Mutation	SNP	T	T	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr10:25888018T>C	ENST00000376351.3	+	11	3822	c.3463T>C	c.(3463-3465)Tat>Cat	p.Y1155H	GPR158_ENST00000490549.1_3'UTR	NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	1155						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						GCGTGGCTCCTATAACTCAAG	0.433000													35	31					0	0	1	0	0
KCNMB3	27094	broad.mit.edu	37	3	178968533	178968533	+	Silent	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:178968533G>C	ENST00000392685.2	-	1	885	c.246C>G	c.(244-246)ctC>ctG	p.L82L	KCNMB3_ENST00000349697.2_Silent_p.L84L|KCNMB3_ENST00000497599.1_Silent_p.L84L|KCNMB3_ENST00000314235.5_Silent_p.L86L|KCNMB3_ENST00000485523.1_Silent_p.L64L	NM_171830.1	NP_741981.1	Q9NPA1	KCMB3_HUMAN	potassium large conductance calcium-activated channel, subfamily M beta member 3	86					detection of calcium ion|platelet activation|regulation of action potential in neuron	voltage-gated potassium channel complex	calcium-activated potassium channel activity|potassium channel regulator activity			NS(1)|large_intestine(1)|lung(2)|stomach(1)	5	all_cancers(143;5.6e-17)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;2.41e-27)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.03)			TTTCTTACCTGAGCATAAAAG	0.478000													5	89					0	0	1	0	0
GRM4	2914	broad.mit.edu	37	6	33996117	33996117	+	Silent	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:33996117C>A	ENST00000538487.2	-	10	2912	c.2469G>T	c.(2467-2469)acG>acT	p.T823T	GRM4_ENST00000545715.1_5'UTR|GRM4_ENST00000535756.1_Silent_p.T690T|GRM4_ENST00000455714.2_Silent_p.T683T|GRM4_ENST00000374177.3_Silent_p.T707T|GRM4_ENST00000609222.1_Silent_p.T690T|GRM4_ENST00000544773.2_Silent_p.T654T|GRM4_ENST00000374181.4_Silent_p.T823T	NM_000841.2|NM_001256811.1	NP_000832.1|NP_001243740.1	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4						activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48					L-Glutamic Acid(DB00142)	TCACCGAGACCGTCAGCGTCG	0.642000													73	51					7.81431e-29	8.47005e-29	1	1	0
UGT2B28	54490	broad.mit.edu	37	4	70146227	70146227	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:70146227G>A	ENST00000335568.5	+	1	11	c.9G>A	c.(7-9)ctG>ctA	p.L3L	UGT2B28_ENST00000511240.1_Silent_p.L3L	NM_053039.1	NP_444267.1	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B28	3					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	31					Flunitrazepam(DB01544)	GGATGGCTCTGAAGTGGACTT	0.408000													126	243					0	0	1	0	0
RBMY2EP	159125	broad.mit.edu	37	Y	23557842	23557842	+	RNA	SNP	T	T	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chrY:23557842T>A	ENST00000444169.1	-	0	215					NR_001574.2																						GCATAATCCCTGGTTTCTTGG	0.353000													128	7					0	0	1	0	0
AZGP1	563	broad.mit.edu	37	7	99564778	99564778	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:99564778C>G	ENST00000292401.4	-	4	881	c.745G>C	c.(745-747)Gag>Cag	p.E249Q	AZGP1_ENST00000483612.1_5'UTR|AZGP1_ENST00000411734.1_3'UTR	NM_001185.3	NP_001176.1	P25311	ZA2G_HUMAN	alpha-2-glycoprotein 1, zinc-binding	249	Ig-like C1-type.				antigen processing and presentation|cell adhesion|immune response|lipid catabolic process|negative regulation of cell proliferation	extracellular region|MHC class I protein complex	fatty acid binding|protein transmembrane transporter activity|ribonuclease activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|stomach(1)	16	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					CCCCGTAACTCAGGCTCCTGC	0.587000													14	30					0	0	1	0	0
GAB2	9846	broad.mit.edu	37	11	77934481	77934481	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:77934481C>T	ENST00000361507.4	-	6	1629	c.1544G>A	c.(1543-1545)cGc>cAc	p.R515H	GAB2_ENST00000340149.2_Missense_Mutation_p.R477H	NM_080491.2	NP_536739.1	Q9UQC2	GAB2_HUMAN	GRB2-associated binding protein 2	515					osteoclast differentiation|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mast cell degranulation	cytosol|plasma membrane	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|transmembrane receptor protein tyrosine kinase adaptor activity		INTS4/GAB2(2)	NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(8)|ovary(5)|skin(1)|upper_aerodigestive_tract(1)	24	all_cancers(14;3.31e-18)|all_epithelial(13;5.3e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.58e-23)			TTTGAGGTTGCGGTTGACAGG	0.547000													6	717					0	0	1	0	0
PAK1IP1	55003	broad.mit.edu	37	6	10695300	10695300	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:10695300G>A	ENST00000379568.3	+	1	373	c.82G>A	c.(82-84)Gag>Aag	p.E28K		NM_017906.2	NP_060376.2	Q9NWT1	PK1IP_HUMAN	PAK1 interacting protein 1	28					negative regulation of signal transduction	nucleolus|plasma membrane		p.E28*(1)		kidney(1)|large_intestine(1)|lung(7)|prostate(2)|upper_aerodigestive_tract(1)	12	Ovarian(93;0.107)|Breast(50;0.137)	all_hematologic(90;0.117)				CGGCGACCACGAGGTGAGATA	0.622000													44	30					0	0	1	0	0
USP24	23358	broad.mit.edu	37	1	55627909	55627909	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:55627909C>T	ENST00000294383.6	-	8	955	c.956G>A	c.(955-957)gGa>gAa	p.G319E	USP24_ENST00000407756.1_Missense_Mutation_p.G207E	NM_015306.2	NP_056121.2	Q9UPU5	UBP24_HUMAN	ubiquitin specific peptidase 24	319					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|cervix(1)|endometrium(8)|kidney(13)|large_intestine(7)|lung(16)|ovary(6)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	60						TGCACACACTCCTAAGGGCTG	0.373000													4	17					0	0	1	0	0
DSE	29940	broad.mit.edu	37	6	116757173	116757173	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:116757173G>C	ENST00000331677.3	+	7	1986	c.1542G>C	c.(1540-1542)aaG>aaC	p.K514N	DSE_ENST00000537543.1_Missense_Mutation_p.K533N|DSE_ENST00000452085.3_Missense_Mutation_p.K514N|DSE_ENST00000359564.2_Missense_Mutation_p.K514N			Q9UL01	DSE_HUMAN	dermatan sulfate epimerase	514					dermatan sulfate biosynthetic process	endoplasmic reticulum|Golgi apparatus|integral to membrane	chondroitin-glucuronate 5-epimerase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(2)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35		all_cancers(87;0.00019)|all_epithelial(87;0.000416)|Ovarian(999;0.133)|Colorectal(196;0.234)		Epithelial(106;0.00915)|OV - Ovarian serous cystadenocarcinoma(136;0.0149)|GBM - Glioblastoma multiforme(226;0.0189)|all cancers(137;0.0262)		CTAAATACAAGCATGACCTGG	0.498000													34	29					0	0	1	0	0
OR7A5	26659	broad.mit.edu	37	19	14939056	14939056	+	Translation_Start_Site	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:14939056G>C	ENST00000322301.3	-	0	85				OR7A5_ENST00000601611.1_Intron|OR7A5_ENST00000594432.1_De_novo_Start_OutOfFrame			Q15622	OR7A5_HUMAN	olfactory receptor, family 7, subfamily A, member 5						sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(4)|endometrium(2)|kidney(4)|large_intestine(3)|lung(6)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	26						GGTTCCATTTGATTGAAGTGA	0.398000													28	47					0	0	1	0	0
SHROOM2	357	broad.mit.edu	37	X	9864259	9864259	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chrX:9864259G>A	ENST00000380913.3	+	4	2401	c.2311G>A	c.(2311-2313)Gag>Aag	p.E771K		NM_001649.2	NP_001640.1	Q13796	SHRM2_HUMAN	shroom family member 2	771	ASD1.				apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity			breast(4)|central_nervous_system(2)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	57		Hepatocellular(5;0.000888)				GAAGATGAACGAGGTGGGCCT	0.577000													20	4					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70489016	70489016	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:70489016G>A	ENST00000310961.5	+	18	2072	c.1654G>A	c.(1654-1656)Gca>Aca	p.A552T	LRRC7_ENST00000035383.5_Missense_Mutation_p.A547T|LRRC7_ENST00000415775.2_Intron|RP11-181B18.1_ENST00000414132.1_RNA			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	547						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						ATTGCCAGTTGCAGCACAATC	0.542000													32	72					0	0	1	0	0
ABCB1	5243	broad.mit.edu	37	7	87190668	87190668	+	Silent	SNP	C	C	G	rs28381867		TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:87190668C>G	ENST00000265724.3	-	9	1155	c.738G>C	c.(736-738)gcG>gcC	p.A246A	ABCB1_ENST00000543898.1_Silent_p.A182A	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	246	ABC transmembrane type-1 1.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	CTTTTGCATACGCTAAGAGTT	0.323000													16	17					0	0	1	0	0
LRRK2	120892	broad.mit.edu	37	12	40728840	40728840	+	Silent	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:40728840G>C	ENST00000298910.7	+	40	5887	c.5829G>C	c.(5827-5829)cgG>cgC	p.R1943R		NM_198578.3	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1943	Protein kinase.				activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TTCGTCCCCGGATGTTGGTGA	0.527000													22	36					0	0	1	0	0
ADAM29	11086	broad.mit.edu	37	4	175896821	175896821	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:175896821C>T	ENST00000359240.3	+	5	815	c.145C>T	c.(145-147)Cca>Tca	p.P49S	ADAM29_ENST00000445694.1_Missense_Mutation_p.P49S|ADAM29_ENST00000404450.4_Missense_Mutation_p.P49S|ADAM29_ENST00000514159.1_Missense_Mutation_p.P49S	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	49					proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		CATGACACCTCCAGGCTGGCT	0.512000													31	30					0	0	1	0	0
RASD2	23551	broad.mit.edu	37	22	35947630	35947630	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr22:35947630G>C	ENST00000216127.4	+	3	994	c.352G>C	c.(352-354)Gag>Cag	p.E118Q		NM_014310.3	NP_055125.2	Q96D21	RHES_HUMAN	RASD family, member 2	118					locomotory behavior|positive regulation of protein kinase B signaling cascade|positive regulation of protein sumoylation|regulation of cAMP-mediated signaling	intracellular|plasma membrane	G-protein beta-subunit binding|GTP binding|GTPase activity			endometrium(2)|large_intestine(1)|lung(8)|prostate(1)|skin(1)	13						GCAGATCCTGGAGGTCAAGTC	0.597000													20	75					0	0	1	0	0
TTPAL	79183	broad.mit.edu	37	20	43117934	43117934	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr20:43117934C>G	ENST00000372904.3	+	6	924	c.781C>G	c.(781-783)Ctc>Gtc	p.L261V	TTPAL_ENST00000262605.4_Missense_Mutation_p.L261V|TTPAL_ENST00000372906.2_3'UTR	NM_024331.4	NP_077307.2	Q9BTX7	TTPAL_HUMAN	tocopherol (alpha) transfer protein-like	261	CRAL-TRIO.					intracellular	transporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(2)|ovary(2)|skin(5)	18						CTTGAACTCTCTCCACACAAA	0.507000													37	65					0	0	1	0	0
DGKB	1607	broad.mit.edu	37	7	14620502	14620502	+	Missense_Mutation	SNP	G	G	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:14620502G>T	ENST00000403951.2	-	19	2016	c.1597C>A	c.(1597-1599)Ctg>Atg	p.L533M	DGKB_ENST00000258767.5_Missense_Mutation_p.L533M|DGKB_ENST00000407950.1_Missense_Mutation_p.L525M|DGKB_ENST00000406247.3_Missense_Mutation_p.L533M|DGKB_ENST00000444700.2_Missense_Mutation_p.L514M|DGKB_ENST00000402815.1_Missense_Mutation_p.L532M|DGKB_ENST00000403963.1_5'UTR|DGKB_ENST00000399322.3_Missense_Mutation_p.L533M			Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta 90kDa	533	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(34)|ovary(4)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72					Phosphatidylserine(DB00144)	CCCCATCGCAGGCATCTTGCT	0.418000													31	16					1.45844e-13	1.55544e-13	1	1	0
LRRC37A3	374819	broad.mit.edu	37	17	62856984	62856984	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:62856984C>G	ENST00000584306.1	-	11	3810	c.3280G>C	c.(3280-3282)Gac>Cac	p.D1094H	LRRC37A3_ENST00000334962.5_Missense_Mutation_p.D71H|LRRC37A3_ENST00000339474.5_Missense_Mutation_p.D212H|LRRC37A3_ENST00000400877.3_Missense_Mutation_p.D132H|LRRC37A3_ENST00000319651.5_Missense_Mutation_p.D1094H	NM_199340.2	NP_955372.2	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	1094						integral to membrane				NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|liver(1)|lung(10)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						CCACTGCTGTCTGAGGGCTCC	0.473000													207	138					0	0	1	0	0
HIST1H2BD	3017	broad.mit.edu	37	6	26158619	26158619	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:26158619C>T	ENST00000289316.2	+	1	246	c.222C>T	c.(220-222)atC>atT	p.I74I	HIST1H2BD_ENST00000377777.4_Silent_p.I74I	NM_138720.2	NP_619790.1	P58876	H2B1D_HUMAN	histone cluster 1, H2bd	74					nucleosome assembly	nucleosome|nucleus	DNA binding			breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	24						TCGAGCGCATCGCAGGCGAGG	0.602000													101	76					0	0	1	0	0
GAPT	202309	broad.mit.edu	37	5	57790589	57790589	+	Nonsense_Mutation	SNP	G	G	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:57790589G>T	ENST00000396776.2	+	3	688	c.226G>T	c.(226-228)Gaa>Taa	p.E76*	GAPT_ENST00000318469.2_Nonsense_Mutation_p.E76*	NM_152687.2	NP_689900.1	Q8N292	GAPT_HUMAN	GRB2-binding adaptor protein, transmembrane	76					B cell activation	integral to membrane|plasma membrane				NS(1)|endometrium(2)|large_intestine(1)|lung(2)|skin(1)	7						AATCTCAGTTGAAACCCAAGA	0.438000													33	19					2.75727e-19	2.96447e-19	1	1	0
APLP2	334	broad.mit.edu	37	11	130005479	130005479	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:130005479G>C	ENST00000263574.5	+	13	1778	c.1706G>C	c.(1705-1707)cGt>cCt	p.R569P	APLP2_ENST00000278756.7_Missense_Mutation_p.R579P|APLP2_ENST00000345598.5_Missense_Mutation_p.R340P|APLP2_ENST00000543137.1_Missense_Mutation_p.R476P|APLP2_ENST00000528499.1_Missense_Mutation_p.R513P|APLP2_ENST00000338167.5_Missense_Mutation_p.R569P|APLP2_ENST00000539648.1_Missense_Mutation_p.R357P	NM_001642.2	NP_001633.1	Q06481	APLP2_HUMAN	amyloid beta (A4) precursor-like protein 2	569					G-protein coupled receptor protein signaling pathway	integral to membrane|nucleus|plasma membrane	DNA binding|identical protein binding|serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(6)|ovary(4)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_hematologic(175;0.0429)	Breast(109;0.00586)|Lung NSC(97;0.00785)|all_lung(97;0.0154)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0197)|Lung(977;0.24)		CAGGAGCAGCGTGCAGATATG	0.582000													50	33					0	0	1	0	0
LILRB3	11025	broad.mit.edu	37	19	54721190	54721190	+	Missense_Mutation	SNP	C	C	T	rs145192800		TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:54721190C>T	ENST00000391750.1	-	13	1883	c.1747G>A	c.(1747-1749)Gag>Aag	p.E583K	LILRB3_ENST00000346401.6_Missense_Mutation_p.E595K|LILRB3_ENST00000407860.2_Missense_Mutation_p.E600K|LILRA6_ENST00000391735.3_3'UTR|LILRB3_ENST00000469273.1_5'UTR|LILRA6_ENST00000419410.2_Missense_Mutation_p.E584K|LILRB3_ENST00000245620.9_Missense_Mutation_p.E584K|LILRB3_ENST00000424807.1_Missense_Mutation_p.E583K|LILRA6_ENST00000440558.2_Missense_Mutation_p.E583K|LILRA6_ENST00000270464.5_Missense_Mutation_p.E584K			O75022	LIRB3_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	583					cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	transmembrane receptor activity			endometrium(3)|kidney(13)|large_intestine(1)|lung(6)|ovary(2)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	34	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGACTCACCTCAGTGTCCATC	0.602000													6	46					0	0	1	0	0
OPTN	10133	broad.mit.edu	37	10	13161005	13161005	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr10:13161005G>A	ENST00000378748.3	+	8	1106	c.744G>A	c.(742-744)gaG>gaA	p.E248E	OPTN_ENST00000378747.3_Silent_p.E248E|OPTN_ENST00000378764.2_Silent_p.E242E|OPTN_ENST00000263036.5_Silent_p.E248E|OPTN_ENST00000378757.2_Silent_p.E248E|OPTN_ENST00000378752.3_Silent_p.E242E	NM_001008211.1|NM_001008213.1	NP_001008212|NP_001008214	Q96CV9	OPTN_HUMAN	optineurin	248					cell death|Golgi ribbon formation|Golgi to plasma membrane protein transport|protein targeting to Golgi|signal transduction	perinuclear region of cytoplasm|trans-Golgi network	protein C-terminus binding			breast(1)|endometrium(2)|large_intestine(5)|lung(9)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	22						AGAAGGTGGAGAGACTTGAAG	0.423000													24	40					0	0	1	0	0
CDCA5	113130	broad.mit.edu	37	11	64847055	64847055	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:64847055C>G	ENST00000275517.3	-	5	620	c.448G>C	c.(448-450)Gag>Cag	p.E150Q	CDCA5_ENST00000404147.3_Missense_Mutation_p.E150Q	NM_080668.3	NP_542399.1	Q96FF9	CDCA5_HUMAN	cell division cycle associated 5	150					cell division|double-strand break repair|G1/S transition of mitotic cell cycle|mitotic chromosome condensation|mitotic metaphase plate congression|mitotic sister chromatid cohesion|regulation of cohesin localization to chromatin	cytoplasm|nuclear chromatin|plasma membrane	chromatin binding|identical protein binding			large_intestine(1)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	7						CCCAGGGTCTCCAGCCGGCTG	0.627000													16	25					0	0	1	0	0
IL3RA	3563	broad.mit.edu	37	X	1475206	1475206	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chrX:1475206C>T	ENST00000331035.4	+	7	1058	c.709C>T	c.(709-711)Cgc>Tgc	p.R237C	IL3RA_ENST00000381469.2_Missense_Mutation_p.R159C	NM_001267713.1|NM_002183.3	NP_001254642.1|NP_002174.1	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha (low affinity)	237						integral to membrane|plasma membrane	interleukin-3 receptor activity			lung(1)|skin(2)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	TCGCAAATTTCGCTATGAGCT	0.463000													69	77					0	0	1	0	0
SLU7	10569	broad.mit.edu	37	5	159839516	159839516	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:159839516G>A	ENST00000297151.4	-	6	968	c.581C>T	c.(580-582)aCa>aTa	p.T194I		NM_006425.4	NP_006416.3	O95391	SLU7_HUMAN	SLU7 splicing factor homolog (S. cerevisiae)	194					alternative nuclear mRNA splicing, via spliceosome|nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|cytoplasm|nuclear speck|small nuclear ribonucleoprotein complex	pre-mRNA 3'-splice site binding|second spliceosomal transesterification activity|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(4)|lung(6)|ovary(1)	20	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GGCTTTCAATGTTCGTTTTGC	0.274000													14	16					0	0	1	0	0
FAM227B	196951	broad.mit.edu	37	15	49881979	49881979	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr15:49881979C>G	ENST00000299338.6	-	4	634	c.331G>C	c.(331-333)Gag>Cag	p.E111Q	FAM227B_ENST00000558594.1_Missense_Mutation_p.E111Q|FAM227B_ENST00000560246.1_Missense_Mutation_p.E111Q|FAM227B_ENST00000561064.1_Missense_Mutation_p.E111Q|FAM227B_ENST00000558862.1_5'UTR	NM_152647.2	NP_689860.2			family with sequence similarity 227, member B																		TCACTTGTCTCAGAAATCATG	0.348000													16	10					0	0	1	0	0
ADCY7	113	broad.mit.edu	37	16	50348262	50348262	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr16:50348262G>C	ENST00000394697.2	+	24	3256	c.2916G>C	c.(2914-2916)atG>atC	p.M972I	ADCY7_ENST00000254235.3_Missense_Mutation_p.M972I			P51828	ADCY7_HUMAN	adenylate cyclase 7	972	Guanylate cyclase 2.				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(1)|cervix(1)|endometrium(5)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	35		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	TCGCCCTGATGAGTAAGCTGG	0.632000													102	45					0	0	1	0	0
ZFP3	124961	broad.mit.edu	37	17	4995011	4995011	+	Nonsense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:4995011C>G	ENST00000318833.3	+	2	548	c.212C>G	c.(211-213)tCa>tGa	p.S71*		NM_153018.2	NP_694563.1	Q96NJ6	ZFP3_HUMAN	ZFP3 zinc finger protein	71					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(3)|prostate(1)	20						GACTTTCCATCAGGGTTGATG	0.468000													5	34					0	0	1	0	0
TEX37	200523	broad.mit.edu	37	2	88828629	88828629	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:88828629C>T	ENST00000303254.3	+	4	322	c.180C>T	c.(178-180)ccC>ccT	p.P60P		NM_152670.2	NP_689883.1			testis expressed 37																		TCCCTAACCCCAACCCCAAGC	0.527000													26	57					0	0	1	0	0
BAG4	9530	broad.mit.edu	37	8	38065106	38065106	+	Nonsense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr8:38065106C>G	ENST00000287322.4	+	3	726	c.455C>G	c.(454-456)tCa>tGa	p.S152*	BAG4_ENST00000432471.2_Nonsense_Mutation_p.S116*|BAG4_ENST00000521282.1_3'UTR	NM_004874.3	NP_004865.1	O95429	BAG4_HUMAN	BCL2-associated athanogene 4	152					anti-apoptosis|apoptosis|protein folding	cytoplasm|nucleus	receptor signaling protein activity			breast(1)|kidney(2)|large_intestine(2)|liver(2)|lung(2)|ovary(1)|urinary_tract(1)	11	Colorectal(12;0.000442)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.121)				GCCTCATACTCAGGGGCTTAT	0.463000													5	43					0	0	1	0	0
TTC3	7267	broad.mit.edu	37	21	38569944	38569944	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr21:38569944G>A	ENST00000399017.2	+	43	8400	c.5653G>A	c.(5653-5655)Gaa>Aaa	p.E1885K	TTC3_ENST00000354749.2_Missense_Mutation_p.E1885K|TTC3_ENST00000355666.1_Missense_Mutation_p.E1885K|TTC3_ENST00000479930.1_3'UTR	NM_003316.3	NP_003307.3	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	1885					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(5)|endometrium(7)|kidney(5)|large_intestine(17)|liver(1)|lung(18)|ovary(4)|prostate(2)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(5)	75		Myeloproliferative disorder(46;0.0412)				GAGTATTGATGAAATTGTCCA	0.328000													30	19					0	0	1	0	0
GPATCH3	63906	broad.mit.edu	37	1	27220739	27220739	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:27220739C>T	ENST00000361720.5	-	3	1062	c.1039G>A	c.(1039-1041)Gag>Aag	p.E347K		NM_022078.2	NP_071361.2	Q96I76	GPTC3_HUMAN	G patch domain containing 3	347						intracellular	nucleic acid binding			endometrium(2)|large_intestine(1)|lung(11)|skin(1)	15		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;3.97e-51)|OV - Ovarian serous cystadenocarcinoma(117;9.55e-30)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|STAD - Stomach adenocarcinoma(196;0.000595)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|READ - Rectum adenocarcinoma(331;0.0419)		CCTTCTTCCTCCTGCCAGAAC	0.552000													44	73					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233122163	233122163	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:233122163G>A	ENST00000258229.9	-	33	6149	c.5915C>T	c.(5914-5916)tCa>tTa	p.S1972L	PCNXL2_ENST00000344698.2_Missense_Mutation_p.S624L	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)		Ser-rich.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				CTCGTGCACTGAGGTGGACGT	0.667000													4	16					0	0	1	0	0
DMD	1756	broad.mit.edu	37	X	32328367	32328367	+	Missense_Mutation	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chrX:32328367C>A	ENST00000357033.4	-	42	6155	c.5949G>T	c.(5947-5949)atG>atT	p.M1983I	DMD_ENST00000378677.2_Missense_Mutation_p.M1979I	NM_000109.3|NM_004006.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	1983					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CAGTCATCACCATCATCGTTT	0.368000													13	21					1.5842e-08	1.66475e-08	1	1	0
KLHL12	59349	broad.mit.edu	37	1	202863829	202863829	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:202863829C>T	ENST00000367261.3	-	9	1402	c.1184G>A	c.(1183-1185)aGt>aAt	p.S395N	KLHL12_ENST00000367259.1_Missense_Mutation_p.S128N|KLHL12_ENST00000435533.3_Missense_Mutation_p.S433N	NM_021633.2	NP_067646.1	Q53G59	KLH12_HUMAN	kelch-like family member 12	395					Wnt receptor signaling pathway		protein binding			NS(3)|breast(2)|endometrium(1)|large_intestine(1)|lung(6)|stomach(1)	14			BRCA - Breast invasive adenocarcinoma(75;0.166)			GCGCTCCATACTGGTGTGACG	0.478000													101	126					0	0	1	0	0
PLXNB1	5364	broad.mit.edu	37	3	48457019	48457019	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:48457019G>C	ENST00000358536.4	-	19	4036	c.3767C>G	c.(3766-3768)tCt>tGt	p.S1256C	PLXNB1_ENST00000448774.2_Intron|PLXNB1_ENST00000456774.1_Missense_Mutation_p.S1073C|PLXNB1_ENST00000465117.1_5'UTR|PLXNB1_ENST00000296440.6_Missense_Mutation_p.S1256C|PLXNB1_ENST00000358459.4_Missense_Mutation_p.S1073C	NM_002673.4	NP_002664.2	O43157	PLXB1_HUMAN	plexin B1	1256	IPT/TIG 3.				axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GGGGCCAGCAGAGGTGATGTT	0.622000													3	4					0	0	1	0	0
ZNF330	27309	broad.mit.edu	37	4	142155112	142155112	+	Missense_Mutation	SNP	G	G	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:142155112G>T	ENST00000262990.4	+	10	1160	c.932G>T	c.(931-933)gGc>gTc	p.G311V	ZNF330_ENST00000421169.2_Missense_Mutation_p.G251V	NM_014487.4	NP_055302.1	Q9Y3S2	ZN330_HUMAN	zinc finger protein 330	311						chromosome, centromeric region|midbody|nucleolus	protein binding|zinc ion binding			kidney(1)|large_intestine(4)|lung(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	14	all_hematologic(180;0.162)					TATGCTAGTGGCTATGCTCAC	0.453000													67	59					2.49587e-40	2.73399e-40	1	1	0
CPD	1362	broad.mit.edu	37	17	28754559	28754559	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:28754559C>T	ENST00000225719.4	+	7	2076	c.2000C>T	c.(1999-2001)tCa>tTa	p.S667L	CPD_ENST00000543464.2_Missense_Mutation_p.S420L	NM_001304.4	NP_001295.2	O75976	CBPD_HUMAN	carboxypeptidase D	667	Carboxypeptidase-like 2.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(13)|skin(5)|stomach(1)|urinary_tract(1)	36						TTTGTACTTTCAGCAAACCTG	0.393000													60	89					0	0	1	0	0
STK3	6788	broad.mit.edu	37	8	99539008	99539008	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr8:99539008C>G	ENST00000523601.1	-	12	1762	c.1363G>C	c.(1363-1365)Gat>Cat	p.D455H	STK3_ENST00000419617.2_Missense_Mutation_p.D427H	NM_001256312.1	NP_001243241.1	Q13188	STK3_HUMAN	serine/threonine kinase 3	427	SARAH.				apoptosis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of apoptosis	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein dimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	17	Breast(36;2.4e-06)	Breast(495;0.106)	OV - Ovarian serous cystadenocarcinoma(57;0.0382)	KIRC - Kidney renal clear cell carcinoma(542;9.44e-06)		TTCCAGTTATCAGGAAAAACG	0.333000													38	65					0	0	1	0	0
ARSI	340075	broad.mit.edu	37	5	149677095	149677095	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:149677095G>A	ENST00000328668.7	-	2	1971	c.1392C>T	c.(1390-1392)ctC>ctT	p.L464L		NM_001012301.2	NP_001012301.1	Q5FYB1	ARSI_HUMAN	arylsulfatase family, member I	464						endoplasmic reticulum|extracellular region	arylsulfatase activity|metal ion binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	23			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGATGTTGAAGAGCCACACGG	0.632000													5	64					0	0	1	0	0
KDM3B	51780	broad.mit.edu	37	5	137762927	137762927	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:137762927G>A	ENST00000314358.5	+	19	4752	c.4552G>A	c.(4552-4554)Gat>Aat	p.D1518N	KDM3B_ENST00000394866.1_Missense_Mutation_p.D1174N|KDM3B_ENST00000542866.1_Missense_Mutation_p.D550N	NM_016604.3	NP_057688	Q7LBC6	KDM3B_HUMAN	lysine (K)-specific demethylase 3B	1518	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(15)|liver(2)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	65						TACCAAACGAGATGGCAGGCT	0.468000													6	98					0	0	1	0	0
AC015849.16	0	broad.mit.edu	37	17	34236434	34236434	+	RNA	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:34236434G>C	ENST00000587132.1	-	0	1593																											TGCTGAGCTTGATCCTGACCC	0.493000													11	37					0	0	1	0	0
SRL	6345	broad.mit.edu	37	16	4242602	4242602	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr16:4242602C>T	ENST00000399609.3	-	6	986	c.974G>A	c.(973-975)aGa>aAa	p.R325K	SRL_ENST00000537996.1_Missense_Mutation_p.R283K	NM_001098814.1	NP_001092284.1	Q86TD4	SRCA_HUMAN	sarcalumenin	784	Acidic domain, probably binds calcium (By similarity).					sarcoplasmic reticulum lumen	GTP binding|GTPase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(8)|ovary(3)|skin(3)	21						GTTCTCCAGTCTGTTCTCGAT	0.537000													8	120					0	0	1	0	0
ADCK5	203054	broad.mit.edu	37	8	145617862	145617862	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr8:145617862C>G	ENST00000308860.6	+	13	1514	c.1470C>G	c.(1468-1470)atC>atG	p.I490M		NM_174922.3	NP_777582.4	Q3MIX3	ADCK5_HUMAN	aarF domain containing kinase 5	490						integral to membrane	protein serine/threonine kinase activity			endometrium(1)|lung(2)|prostate(2)|skin(1)|stomach(2)	8	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;8.96e-41)|Epithelial(56;4.08e-40)|all cancers(56;4.51e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			TGCGCGCTATCAACGTGGCCC	0.697000													20	6					0	0	1	0	0
NTNG2	84628	broad.mit.edu	37	9	135116329	135116329	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr9:135116329G>A	ENST00000393229.3	+	7	2031	c.1255G>A	c.(1255-1257)Gac>Aac	p.D419N	NTNG2_ENST00000393228.4_Missense_Mutation_p.D411N|NTNG2_ENST00000360670.3_Missense_Mutation_p.D425N|NTNG2_ENST00000490694.1_3'UTR	NM_032536.2	NP_115925.2	Q96CW9	NTNG2_HUMAN	netrin G2	419	Laminin EGF-like 3.				axonogenesis	anchored to plasma membrane				central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	29				OV - Ovarian serous cystadenocarcinoma(145;1.23e-05)|Epithelial(140;0.000173)		CTCCGTGCACGACCGGTGCAA	0.697000													16	3					0	0	1	0	0
MZT2A	653784	broad.mit.edu	37	2	132241715	132241715	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:132241715C>G	ENST00000309451.6	-	3	441	c.396G>C	c.(394-396)caG>caC	p.Q132H	MZT2A_ENST00000410036.2_5'UTR	NM_001085365.1	NP_001078834.1	Q6P582	MZT2A_HUMAN	mitotic spindle organizing protein 2A	132						centrosome|gamma-tubulin ring complex|spindle				breast(1)|lung(1)	2						GTGGCATCCTCTGGCTGGATC	0.647000													70	29					0	0	1	0	0
FAM188B	84182	broad.mit.edu	37	7	30893019	30893019	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:30893019C>T	ENST00000265299.6	+	12	1698	c.1621C>T	c.(1621-1623)Cac>Tac	p.H541Y	INMT-FAM188B_ENST00000458257.1_3'UTR|AQP1_ENST00000509504.1_Missense_Mutation_p.H4Y|AQP1_ENST00000434909.2_5'UTR	NM_032222.2	NP_115598.2	Q4G0A6	F188B_HUMAN	family with sequence similarity 188, member B	541										endometrium(1)|large_intestine(5)|lung(19)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						GCTTACGCTTCACAGTTTGAC	0.502000													15	33					0	0	1	0	0
FARS2	10667	broad.mit.edu	37	6	5368821	5368821	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:5368821C>T	ENST00000324331.6	+	2	354	c.18C>T	c.(16-18)ctC>ctT	p.L6L	FARS2_ENST00000274680.4_Silent_p.L6L			O95363	SYFM_HUMAN	phenylalanyl-tRNA synthetase 2, mitochondrial	6					phenylalanyl-tRNA aminoacylation|tRNA processing	mitochondrial matrix|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|tRNA binding			endometrium(3)|kidney(1)|large_intestine(5)|lung(3)|prostate(1)|stomach(2)	15	Ovarian(93;0.11)	all_hematologic(90;0.0104)			L-Phenylalanine(DB00120)	GCTCAGCTCTCAGGAGAGGTG	0.547000													52	31					0	0	1	0	0
GMPR2	51292	broad.mit.edu	37	14	24707973	24707973	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr14:24707973G>C	ENST00000557854.1	+	8	1550	c.1273G>C	c.(1273-1275)Gag>Cag	p.E425Q	GMPR2_ENST00000348719.7_Missense_Mutation_p.E407Q|GMPR2_ENST00000559836.1_Missense_Mutation_p.E346Q|GMPR2_ENST00000559910.1_Missense_Mutation_p.E313Q|GMPR2_ENST00000399440.2_Missense_Mutation_p.E346Q|GMPR2_ENST00000456667.3_Missense_Mutation_p.E318Q|GMPR2_ENST00000420554.2_Missense_Mutation_p.E364Q|GMPR2_ENST00000355299.4_Missense_Mutation_p.E346Q|GMPR2_ENST00000559104.1_Missense_Mutation_p.E331Q	NM_001283022.1	NP_001269951.1	Q9P2T1	GMPR2_HUMAN	guanosine monophosphate reductase 2	346					nucleotide metabolic process|purine base metabolic process|purine-containing compound salvage	cytosol	GMP reductase activity|metal ion binding			large_intestine(4)|lung(3)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	12				GBM - Glioblastoma multiforme(265;0.0181)		AATCTTCAGTGAGGCGTGCTA	0.557000													30	2					0	0	1	0	0
NADSYN1	55191	broad.mit.edu	37	11	71191848	71191848	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:71191848C>T	ENST00000319023.2	+	11	1109	c.921C>T	c.(919-921)ctC>ctT	p.L307L	NADSYN1_ENST00000526039.2_3'UTR|NADSYN1_ENST00000539574.1_Silent_p.L47L|NADSYN1_ENST00000530055.1_5'UTR	NM_018161.4	NP_060631.2	Q6IA69	NADE_HUMAN	NAD synthetase 1	307					NAD biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|NAD+ synthase (glutamine-hydrolyzing) activity|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	25					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	ACTTTGCCCTCTCGTGCCACG	0.597000													29	5					0	0	1	0	0
DLGAP2	9228	broad.mit.edu	37	8	1626493	1626493	+	Nonsense_Mutation	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr8:1626493C>A	ENST00000421627.2	+	9	2296	c.2162C>A	c.(2161-2163)tCa>tAa	p.S721*	DLGAP2_ENST00000524065.1_3'UTR	NM_004745.3	NP_004736.2	Q9P1A6	DLGP2_HUMAN	discs, large (Drosophila) homolog-associated protein 2	800					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding			breast(1)|endometrium(6)|lung(31)|prostate(3)	41		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		CAGTTCGGCTCATCCTTCCAG	0.612000													33	8					2.80507e-11	2.96782e-11	1	1	0
LAMB3	3914	broad.mit.edu	37	1	209800260	209800260	+	Missense_Mutation	SNP	G	G	A	rs78788119	byFrequency	TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:209800260G>A	ENST00000391911.1	-	12	1938	c.1549C>T	c.(1549-1551)Cgc>Tgc	p.R517C	LAMB3_ENST00000367030.3_Missense_Mutation_p.R517C|LAMB3_ENST00000356082.4_Missense_Mutation_p.R517C	NM_001017402.1	NP_001017402.1	Q13751	LAMB3_HUMAN	laminin, beta 3	517	Laminin EGF-like 5.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		GGACACTGGCGGATGGCTGCA	0.667000													12	24					0	0	1	0	0
RILPL1	353116	broad.mit.edu	37	12	123984052	123984052	+	Missense_Mutation	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:123984052C>A	ENST00000376874.4	-	3	727	c.492G>T	c.(490-492)aaG>aaT	p.K164N	RILPL1_ENST00000340724.6_Missense_Mutation_p.K12N	NM_178314.3	NP_847884.2	Q5EBL4	RIPL1_HUMAN	Rab interacting lysosomal protein-like 1	164					neuroprotection	cytosol				endometrium(1)|kidney(2)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	7	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000224)|Epithelial(86;0.00067)|all cancers(50;0.00836)|BRCA - Breast invasive adenocarcinoma(302;0.197)		CCTTCAGCTTCTTCATCACCT	0.572000													7	43					7.48243e-07	7.76636e-07	1	1	0
IRS2	8660	broad.mit.edu	37	13	110435761	110435761	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr13:110435761G>A	ENST00000375856.3	-	1	3154	c.2640C>T	c.(2638-2640)ttC>ttT	p.F880F		NM_003749.2	NP_003740.2	Q9Y4H2	IRS2_HUMAN	insulin receptor substrate 2	880					fibroblast growth factor receptor signaling pathway|glucose metabolic process|insulin receptor signaling pathway|lipid homeostasis|negative regulation of B cell apoptosis|negative regulation of kinase activity|negative regulation of plasma membrane long-chain fatty acid transport|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of B cell proliferation|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|response to glucose stimulus	cytosol|plasma membrane	insulin receptor binding|signal transducer activity			kidney(2)|large_intestine(2)|lung(8)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	19	all_cancers(4;7.57e-15)|all_epithelial(4;5.91e-09)|all_lung(23;7.64e-07)|Lung NSC(43;0.000183)|Colorectal(4;0.00159)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0155)	Breast(118;0.159)	all cancers(43;0.00815)|BRCA - Breast invasive adenocarcinoma(86;0.11)|Epithelial(84;0.127)|GBM - Glioblastoma multiforme(44;0.147)			GCTGGCCCAAGAAGCCCTCCG	0.771000													5	2					0	0	1	0	0
ARHGAP10	79658	broad.mit.edu	37	4	148787895	148787895	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:148787895C>G	ENST00000336498.3	+	7	869	c.630C>G	c.(628-630)ttC>ttG	p.F210L		NM_024605.3	NP_078881.3	A1A4S6	RHG10_HUMAN	Rho GTPase activating protein 10	210	BAR.				apoptosis|filopodium assembly|regulation of apoptosis|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm|plasma membrane	cytoskeletal adaptor activity|SH3 domain binding			autonomic_ganglia(2)|endometrium(5)|kidney(2)|large_intestine(4)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	33	all_hematologic(180;0.151)	Renal(17;0.0166)		GBM - Glioblastoma multiforme(119;0.0423)		TGTTTACCTTCTATCATCAGG	0.338000											OREG0016355	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	95					0	0	1	0	0
CES1	1066	broad.mit.edu	37	16	55855391	55855391	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr16:55855391G>C	ENST00000422046.2	-	5	860	c.579C>G	c.(577-579)gaC>gaG	p.D193E	CES1_ENST00000566555.1_5'UTR|CES1_ENST00000360526.3_Missense_Mutation_p.D194E|CES1_ENST00000361503.4_Missense_Mutation_p.D193E			P23141	EST1_HUMAN	carboxylesterase 1	193					response to toxin	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity								all cancers(182;0.13)|Epithelial(162;0.137)	Aminoglutethimide(DB00357)|Bezafibrate(DB01393)|Cholestyramine(DB01432)|Moexipril(DB00691)	CAGCCACCTGGTCCAGGTGAC	0.597000													13	62					0	0	1	0	0
ACPP	55	broad.mit.edu	37	3	132086582	132086582	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:132086582G>A	ENST00000351273.7	+	11	1223	c.1173G>A	c.(1171-1173)ctG>ctA	p.L391L		NM_001134194.1	NP_001127666.1	P15309	PPAP_HUMAN	acid phosphatase, prostate	0						extracellular region|lysosomal membrane	5'-nucleotidase activity|acid phosphatase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(5)|lung(13)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	27						CCTTTTGCCTGATATCTGCTG	0.398000													79	222					0	0	1	0	0
CNNM2	54805	broad.mit.edu	37	10	104679089	104679089	+	Silent	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr10:104679089G>C	ENST00000369878.4	+	1	1040	c.852G>C	c.(850-852)ccG>ccC	p.P284P	CNNM2_ENST00000433628.2_Silent_p.P284P|CNNM2_ENST00000369875.3_Silent_p.P284P	NM_017649.4	NP_060119.3	Q9H8M5	CNNM2_HUMAN	cyclin M2		DUF21.				ion transport	integral to membrane				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|urinary_tract(1)	19		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		CCCTGGACCCGATGGAGCTGC	0.622000													14	29					0	0	1	0	0
DNAAF1	123872	broad.mit.edu	37	16	84199470	84199470	+	Missense_Mutation	SNP	G	G	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr16:84199470G>T	ENST00000378553.5	+	7	1069	c.945G>T	c.(943-945)aaG>aaT	p.K315N	DNAAF1_ENST00000563818.1_3'UTR|DNAAF1_ENST00000334315.5_Missense_Mutation_p.K315N	NM_178452.4	NP_848547.4	Q8NEP3	DAAF1_HUMAN	dynein, axonemal, assembly factor 1	315					axonemal dynein complex assembly|cilium morphogenesis	cilium axoneme|cytoplasm|spindle pole	dynein binding			NS(1)|endometrium(7)|kidney(1)|large_intestine(6)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|stomach(4)|urinary_tract(1)	41						GGGAGCGGAAGAAGATCACAG	0.547000													13	132					3.27435e-08	3.43696e-08	1	1	0
NDST3	9348	broad.mit.edu	37	4	119158324	119158324	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:119158324G>A	ENST00000296499.5	+	10	2470	c.2067G>A	c.(2065-2067)aaG>aaA	p.K689K		NM_004784.2	NP_004775.1	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3	689	Heparan sulfate N-sulfotransferase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(23)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	54						CCAAAGCCAAGATTATCACCA	0.443000													23	42					0	0	1	0	0
COL10A1	1300	broad.mit.edu	37	6	116442971	116442971	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:116442971G>A	ENST00000327673.4	-	2	715	c.308C>T	c.(307-309)tCa>tTa	p.S103L	COL10A1_ENST00000243222.4_Missense_Mutation_p.S103L|AL121963.1_ENST00000430695.1_Missense_Mutation_p.D118N|NT5DC1_ENST00000319550.4_Intron			Q03692	COAA1_HUMAN	collagen, type X, alpha 1	103	Triple-helical region.				skeletal system development	collagen	metal ion binding			central_nervous_system(1)|endometrium(2)|lung(6)|skin(3)|upper_aerodigestive_tract(1)	13		all_cancers(87;0.0176)|all_epithelial(87;0.0263)|Colorectal(196;0.234)		all cancers(137;0.0157)|OV - Ovarian serous cystadenocarcinoma(136;0.0325)|GBM - Glioblastoma multiforme(226;0.0446)|Epithelial(106;0.0711)		CCCTACAGCTGATGGTCCCGG	0.592000													25	23					0	0	1	0	0
RNF216	54476	broad.mit.edu	37	7	5680995	5680995	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:5680995C>G	ENST00000425013.2	-	15	2225	c.2001G>C	c.(1999-2001)atG>atC	p.M667I	RNF216_ENST00000469375.1_5'UTR|RNF216_ENST00000389902.3_Missense_Mutation_p.M724I	NM_207111.3|NM_207116.2	NP_996994.1|NP_996999.1	Q9NWF9	RN216_HUMAN	ring finger protein 216	667					apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus	ligase activity|protein binding|zinc ion binding		FBXL18/RNF216(2)	breast(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)|skin(1)|urinary_tract(4)	33		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)		GGGCAGCAGTCATTTTTTCTT	0.428000													30	12					0	0	1	0	0
KIAA1109	84162	broad.mit.edu	37	4	123132056	123132056	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:123132056G>C	ENST00000264501.4	+	20	2426	c.2053G>C	c.(2053-2055)Gag>Cag	p.E685Q	KIAA1109_ENST00000388738.3_Missense_Mutation_p.E685Q|KIAA1109_ENST00000495260.1_3'UTR|KIAA1109_ENST00000455637.1_Missense_Mutation_p.E685Q			Q2LD37	K1109_HUMAN	KIAA1109	685					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						AGAAATGGAAGAGACAATGCT	0.393000													29	41					0	0	1	0	0
HNRNPA2B1	3181	broad.mit.edu	37	7	26232148	26232148	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:26232148C>T	ENST00000354667.4	-	11	1218	c.1050G>A	c.(1048-1050)agG>agA	p.R350R	HNRNPA2B1_ENST00000356674.7_Silent_p.R338R	NM_031243.2	NP_112533.1	P22626	ROA2_HUMAN	heterogeneous nuclear ribonucleoprotein A2/B1	350	Gly-rich.				RNA transport	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|RNA binding|single-stranded telomeric DNA binding		HNRNPA2B1/ETV1(8)	breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	22						AGTATCGGCTCCTCCCACCAT	0.418000			T	ETV1	prostate								39	145					0	0	1	0	0
KLHL35	283212	broad.mit.edu	37	11	75139672	75139672	+	Splice_Site	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:75139672C>G	ENST00000539798.1	-	2	881		c.e2-1		KLHL35_ENST00000376292.4_Splice_Site	NM_001039548.2	NP_001034637.2	Q6PF15	KLH35_HUMAN	kelch-like family member 35											lung(2)|stomach(1)	3						GTCCATGAATCTGGCGTGCGG	0.612000													18	64					0	0	1	0	0
HEYL	26508	broad.mit.edu	37	1	40095976	40095976	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:40095976G>A	ENST00000372852.3	-	4	555	c.236C>T	c.(235-237)tCt>tTt	p.S79F	HEYL_ENST00000535435.1_Missense_Mutation_p.S51F	NM_014571.3	NP_055386	Q9NQ87	HEYL_HUMAN	hes-related family bHLH transcription factor with YRPW motif-like	79	Helix-loop-helix motif.|Transcriptional repression and interaction with NCOR1 and SIN3A (By similarity).				multicellular organismal development|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(1)|large_intestine(2)|lung(2)|ovary(1)	7	Lung NSC(20;3.81e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.1e-18)|Epithelial(16;2.77e-17)|all cancers(16;5.64e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			CAGCTTGGAAGAGCCCTGCGG	0.542000													6	351					0	0	1	0	0
ASXL1	171023	broad.mit.edu	37	20	31021332	31021332	+	Nonsense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr20:31021332C>G	ENST00000375687.4	+	12	1755	c.1331C>G	c.(1330-1332)tCa>tGa	p.S444*	ASXL1_ENST00000306058.5_Nonsense_Mutation_p.S439*	NM_015338.5	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 (Drosophila)	444					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(655)|kidney(5)|large_intestine(18)|liver(1)|lung(27)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	722						TCTGTGGCCTCAGATGTTCCC	0.562000			"""F, N, Mis"""		"""MDS, CMML"""								79	184					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78592390	78592390	+	Missense_Mutation	SNP	A	A	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:78592390A>G	ENST00000397909.2	+	36	6625	c.6452A>G	c.(6451-6453)tAt>tGt	p.Y2151C	NAV3_ENST00000536525.2_Missense_Mutation_p.Y2129C|NAV3_ENST00000228327.6_Missense_Mutation_p.Y2129C|NAV3_ENST00000266692.7_Missense_Mutation_p.Y1952C			Q8IVL0	NAV3_HUMAN	neuron navigator 3	2151						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						tCTAGTCCATATATTATTGGA	0.274000										HNSCC(70;0.22)			48	32					0	0	1	0	0
FAM19A5	25817	broad.mit.edu	37	22	48972292	48972292	+	Translation_Start_Site	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr22:48972292G>A	ENST00000358295.5	+	0	175				FAM19A5_ENST00000402357.1_Intron|FAM19A5_ENST00000473898.1_3'UTR	NM_015381.5	NP_056196.2	Q7Z5A7	F19A5_HUMAN	family with sequence similarity 19 (chemokine (C-C motif)-like), member A5							extracellular region|integral to membrane				large_intestine(1)|lung(6)	7		all_cancers(38;2.95e-11)|all_epithelial(38;3.07e-10)|all_lung(38;2.89e-05)|Breast(42;0.000396)|Lung NSC(38;0.000471)|Ovarian(80;0.00934)|Lung SC(80;0.195)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0227)|BRCA - Breast invasive adenocarcinoma(115;0.119)		GGGACTCCGCGATGCAGCTCC	0.697000													4	8					0	0	1	0	0
ZNF350	59348	broad.mit.edu	37	19	52468933	52468933	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:52468933C>T	ENST00000243644.4	-	5	1000	c.773G>A	c.(772-774)gGa>gAa	p.G258E	HCCAT3_ENST00000595010.1_RNA|HCCAT3_ENST00000600253.1_RNA	NM_021632.3	NP_067645.3	Q9GZX5	ZN350_HUMAN	zinc finger protein 350	258					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix|transcriptional repressor complex	DNA binding|protein binding|zinc ion binding			breast(4)|endometrium(3)|kidney(3)|large_intestine(7)|lung(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26		all_neural(266;0.0505)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0179)		AGGTTTTTCTCCTGTATGAGT	0.423000													24	70					0	0	1	0	0
TRAK1	22906	broad.mit.edu	37	3	42251402	42251402	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:42251402G>A	ENST00000327628.5	+	14	2288	c.1888G>A	c.(1888-1890)Gaa>Aaa	p.E630K	TRAK1_ENST00000487159.1_3'UTR|TRAK1_ENST00000341421.3_Missense_Mutation_p.E572K|TRAK1_ENST00000396175.1_Missense_Mutation_p.E572K	NM_001042646.2	NP_001036111.1	Q9UPV9	TRAK1_HUMAN	trafficking protein, kinesin binding 1	630					endosome to lysosome transport|protein O-linked glycosylation|protein targeting|regulation of transcription from RNA polymerase II promoter	early endosome|mitochondrion|nucleus				central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(8)|lung(6)|ovary(1)|upper_aerodigestive_tract(2)	22						CGACTTTGAAGAAGATGACAC	0.587000													7	153					0	0	1	0	0
GRIK4	2900	broad.mit.edu	37	11	120811137	120811137	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:120811137C>G	ENST00000527524.2	+	14	1845	c.1558C>G	c.(1558-1560)Ctg>Gtg	p.L520V	GRIK4_ENST00000438375.2_Missense_Mutation_p.L520V	NM_001282470.1	NP_001269399.1	Q16099	GRIK4_HUMAN	glutamate receptor, ionotropic, kainate 4	520					glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(20)|liver(1)|lung(29)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	69		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	ATTCATGACTCTGGGAATTAG	0.403000													46	8					0	0	1	0	0
SMC6	79677	broad.mit.edu	37	2	17889926	17889926	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:17889926C>G	ENST00000448223.2	-	17	2094	c.1825G>C	c.(1825-1827)Gag>Cag	p.E609Q	SMC6_ENST00000402989.1_Missense_Mutation_p.E609Q|SMC6_ENST00000351948.4_Missense_Mutation_p.E609Q|SMC6_ENST00000381272.4_Missense_Mutation_p.E635Q	NM_001142286.1	NP_001135758.1	Q96SB8	SMC6_HUMAN	structural maintenance of chromosomes 6	609	Flexible hinge.				DNA recombination|DNA repair	chromosome|nucleus	ATP binding			NS(1)|biliary_tract(1)|breast(6)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	43	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					AGCACTGTCTCTATGCCTCTC	0.343000													11	37					0	0	1	0	0
PPP2R3B	28227	broad.mit.edu	37	X	295189	295189	+	Missense_Mutation	SNP	C	C	G	rs143890778	byFrequency	TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chrX:295189C>G	ENST00000390665.3	-	13	1659	c.1641G>C	c.(1639-1641)caG>caC	p.Q547H		NM_013239.4	NP_037371.2	Q9Y5P8	P2R3B_HUMAN	protein phosphatase 2, regulatory subunit B'', beta	547					cell cycle arrest|protein dephosphorylation	nucleus|protein phosphatase type 2A complex	calcium ion binding|protein phosphatase type 2A regulator activity|protein serine/threonine phosphatase activity			endometrium(5)|lung(5)|skin(1)	11		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				AGAAGGGCCTCTGGGCCAGCG	0.706000													29	22					0	0	1	0	0
CHD5	26038	broad.mit.edu	37	1	6185886	6185886	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:6185886C>T	ENST00000262450.3	-	27	4210	c.4111G>A	c.(4111-4113)Gaa>Aaa	p.E1371K	CHD5_ENST00000378021.1_Missense_Mutation_p.E228K	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1371					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		ATGGAATATTCTGACTGGTTA	0.552000													157	127					0	0	1	0	0
SPERT	220082	broad.mit.edu	37	13	46287777	46287777	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr13:46287777C>G	ENST00000378966.3	+	2	925	c.509C>G	c.(508-510)tCg>tGg	p.S170W	SPERT_ENST00000310521.1_Missense_Mutation_p.S206W			Q8NA61	SPERT_HUMAN	spermatid associated	206						cytoplasmic membrane-bounded vesicle				NS(1)|central_nervous_system(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	15		Breast(56;0.000819)|Lung NSC(96;0.00227)|Prostate(109;0.00703)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.26e-05)		CACAAGGCCTCGCTGGGCCGA	0.642000													44	30					0	0	1	0	0
OGG1	4968	broad.mit.edu	37	3	9798753	9798753	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:9798753C>T	ENST00000302003.7	+	7	1317	c.974C>T	c.(973-975)tCa>tTa	p.S325L	OGG1_ENST00000349503.5_Intron|OGG1_ENST00000302036.7_Intron|OGG1_ENST00000302008.8_Intron|OGG1_ENST00000449570.2_Intron|OGG1_ENST00000383826.5_Intron|OGG1_ENST00000344629.7_Silent_p.F319F|OGG1_ENST00000339511.5_3'UTR	NM_002542.5|NM_016820.3	NP_002533.1|NP_058213.1	O15527	OGG1_HUMAN	8-oxoguanine DNA glycosylase	0					depurination|nucleotide-excision repair|regulation of protein import into nucleus, translocation|regulation of transcription, DNA-dependent|response to oxidative stress|response to radiation	mitochondrion|nuclear matrix|nuclear speck	damaged DNA binding|endonuclease activity|oxidized purine base lesion DNA N-glycosylase activity|protein binding			kidney(2)|large_intestine(2)|lung(2)|skin(1)|urinary_tract(1)	8	Medulloblastoma(99;0.227)					AGGTGCTGTTCAGTGCCGACC	0.602000								Base excision repair (BER), DNA glycosylases					11	302					0	0	1	0	0
ULK1	8408	broad.mit.edu	37	12	132379588	132379588	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:132379588C>G	ENST00000321867.4	+	1	393	c.42C>G	c.(40-42)ttC>ttG	p.F14L		NM_003565.2	NP_003556	O75385	ULK1_HUMAN	unc-51 like autophagy activating kinase 1	14					autophagy|protein localization|regulation of autophagy	autophagic vacuole|cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	ATP binding|protein complex binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|prostate(2)|skin(2)|urinary_tract(2)	29	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.07e-08)|Epithelial(86;2.56e-07)|all cancers(50;3.01e-07)		TGGGCAAGTTCGAGTTCTCCC	0.776000													4	14					0	0	1	0	0
SRPK2	6733	broad.mit.edu	37	7	104782915	104782915	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:104782915C>T	ENST00000357311.3	-	10	1221	c.1050G>A	c.(1048-1050)gaG>gaA	p.E350E	SRPK2_ENST00000393651.3_Silent_p.E361E|SRPK2_ENST00000489828.1_Silent_p.E350E	NM_001278273.1|NM_182691.1	NP_001265202.1|NP_872633.1	P78362	SRPK2_HUMAN	SRSF protein kinase 2	350	Protein kinase.				angiogenesis|cell differentiation|intracellular protein kinase cascade|negative regulation of viral genome replication|nuclear speck organization|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of gene expression|positive regulation of neuron apoptosis|positive regulation of viral genome replication|spliceosome assembly	cytoplasm|nucleolus	14-3-3 protein binding|ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|kidney(11)|large_intestine(6)|lung(4)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	35						CATCTTCTTTCTCTTCCTGGT	0.378000													5	71					0	0	1	0	0
APC	324	broad.mit.edu	37	5	112174552	112174552	+	Silent	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:112174552C>G	ENST00000457016.1	+	16	3641	c.3261C>G	c.(3259-3261)ctC>ctG	p.L1087L	APC_ENST00000508376.2_Silent_p.L1087L|CTC-554D6.1_ENST00000520401.1_Intron|APC_ENST00000257430.4_Silent_p.L1087L			P25054	APC_HUMAN	adenomatous polyposis coli	1087	Responsible for down-regulation through a process mediated by direct ubiquitination.|Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.L1087L(1)|p.?(1)		NS(7)|adrenal_gland(6)|biliary_tract(5)|bone(6)|breast(29)|central_nervous_system(12)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(2768)|liver(15)|lung(39)|oesophagus(1)|ovary(12)|pancreas(27)|prostate(15)|salivary_gland(2)|skin(14)|small_intestine(34)|soft_tissue(55)|stomach(136)|thyroid(22)|upper_aerodigestive_tract(8)|urinary_tract(20)	3261		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		ATAAACACCTCAAGTTCCAAC	0.388000		12	"""D, Mis, N, F, S"""		"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""	"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""			Turcot syndrome;Hereditary Desmoid Disease;Familial Adenomatous Polyposis	TSP Lung(16;0.13)			22	180					0	0	1	0	0
ZNF776	284309	broad.mit.edu	37	19	58265746	58265746	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:58265746G>A	ENST00000317178.5	+	3	1511	c.1248G>A	c.(1246-1248)aaG>aaA	p.K416K	ZNF776_ENST00000489376.1_3'UTR	NM_173632.3	NP_775903.3			zinc finger protein 776											cervix(1)|endometrium(2)|kidney(13)|large_intestine(3)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	31		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0256)		TTAGGTACAAGTCACACCTCA	0.423000													5	128					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40364331	40364331	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:40364331C>T	ENST00000221347.6	-	31	14318	c.14311G>A	c.(14311-14313)Gaa>Aaa	p.E4771K		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	4771	TIL 11.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			ACACAGCCTTCACGGCAGGCC	0.652000													54	74					0	0	1	0	0
ELF3	1999	broad.mit.edu	37	1	201981489	201981489	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:201981489G>A	ENST00000359651.3	+	3	3595	c.403G>A	c.(403-405)Gag>Aag	p.E135K	ELF3_ENST00000367284.5_Missense_Mutation_p.E135K|ELF3_ENST00000367283.3_Missense_Mutation_p.E135K|RP11-510N19.5_ENST00000504773.1_RNA|ELF3_ENST00000495848.1_3'UTR			P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription factor, epithelial-specific )	135					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	20						CTCTTCTGATGAGCTCAGTTG	0.572000													40	51					0	0	1	0	0
CLSPN	63967	broad.mit.edu	37	1	36212422	36212422	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:36212422C>G	ENST00000251195.5	-	15	2895	c.2799G>C	c.(2797-2799)aaG>aaC	p.K933N	CLSPN_ENST00000520551.1_Missense_Mutation_p.K880N|CLSPN_ENST00000373220.3_Missense_Mutation_p.K869N|CLSPN_ENST00000318121.3_Missense_Mutation_p.K933N			Q9HAW4	CLSPN_HUMAN	claspin	933				SDK -> GDE (in Ref. 3; AAI15026).	activation of protein kinase activity|cell cycle|cellular component disassembly involved in apoptosis|DNA repair|DNA replication|G2/M transition DNA damage checkpoint|mitotic cell cycle DNA replication checkpoint|peptidyl-serine phosphorylation	nucleoplasm	anaphase-promoting complex binding|DNA binding			NS(2)|breast(3)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TGTTCTCTTTCTTGTCACTCT	0.428000													39	43					0	0	1	0	0
RABEPK	10244	broad.mit.edu	37	9	127996110	127996110	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr9:127996110G>C	ENST00000373538.3	+	8	1280	c.970G>C	c.(970-972)Gag>Cag	p.E324Q	RABEPK_ENST00000394124.4_3'UTR|RABEPK_ENST00000259460.8_Missense_Mutation_p.E273Q|RABEPK_ENST00000394125.4_Missense_Mutation_p.E324Q	NM_005833.3	NP_005824.2	Q7Z6M1	RABEK_HUMAN	Rab9 effector protein with kelch motifs	324					receptor-mediated endocytosis|vesicle docking involved in exocytosis	endosome membrane|plasma membrane				NS(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(3)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	15						CCATGAAGCTGAGAAAGAGGA	0.478000													47	9					0	0	1	0	0
ZFYVE1	53349	broad.mit.edu	37	14	73460037	73460037	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr14:73460037G>A	ENST00000556143.1	-	4	1737	c.1017C>T	c.(1015-1017)ctC>ctT	p.L339L	ZFYVE1_ENST00000318876.5_Silent_p.L339L|ZFYVE1_ENST00000553891.1_Silent_p.L339L	NM_001281735.1|NM_021260.2	NP_001268664.1|NP_067083.1	Q9HBF4	ZFYV1_HUMAN	zinc finger, FYVE domain containing 1	339						endoplasmic reticulum|Golgi stack|perinuclear region of cytoplasm	1-phosphatidylinositol binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(17)|ovary(1)|prostate(2)|skin(1)	35		all_lung(585;1.33e-09)		OV - Ovarian serous cystadenocarcinoma(108;1.6e-46)|BRCA - Breast invasive adenocarcinoma(234;0.00349)		GGTCCTGGATGAGCTTCTCTG	0.483000													5	49					0	0	1	0	0
CYFIP1	23191	broad.mit.edu	37	15	22962450	22962450	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr15:22962450G>C	ENST00000313077.7	+	20	2295	c.2170G>C	c.(2170-2172)Gat>Cat	p.D724H	CYFIP1_ENST00000560848.1_Missense_Mutation_p.D724H|CYFIP1_ENST00000435939.2_Missense_Mutation_p.D293H	NM_014608.2	NP_055423.1	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1	724					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(1)|lung(14)|ovary(4)|pancreas(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	40		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		TTTGCTTCTTGATAAACGGTT	0.433000													11	33					0	0	1	0	0
POLR3A	11128	broad.mit.edu	37	10	79781631	79781631	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr10:79781631C>T	ENST00000372371.3	-	7	1172	c.1035G>A	c.(1033-1035)ctG>ctA	p.L345L		NM_007055.3	NP_008986.2	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide A, 155kDa	345					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding	p.L345L(1)		breast(1)|endometrium(7)|kidney(3)|large_intestine(13)|lung(25)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	59	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			GTTTTCCCTTCAGGCGTTGGA	0.537000													8	57					0	0	1	0	0
SLC52A2	79581	broad.mit.edu	37	8	145583671	145583671	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr8:145583671G>A	ENST00000532887.1	+	3	1102	c.519G>A	c.(517-519)ccG>ccA	p.P173P	SLC52A2_ENST00000402965.1_Silent_p.P173P|SLC52A2_ENST00000526752.1_Intron|SLC52A2_ENST00000527078.1_Silent_p.P173P|SLC52A2_ENST00000530047.1_Silent_p.P173P|SLC52A2_ENST00000329994.2_Silent_p.P173P|SLC52A2_ENST00000540505.1_Silent_p.P85P			Q9HAB3	RFT3_HUMAN	solute carrier family 52 (riboflavin transporter), member 2	173						integral to plasma membrane	receptor activity|riboflavin transporter activity										TCGAGTGCCCGCCAGCCCCCA	0.657000													6	236					0	0	1	0	0
NF1	4763	broad.mit.edu	37	17	29562997	29562997	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:29562997C>T	ENST00000358273.4	+	29	4315	c.3932C>T	c.(3931-3933)tCc>tTc	p.S1311F	NF1_ENST00000356175.3_Missense_Mutation_p.S1311F	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	1311	Ras-GAP.				actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(4)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		GTGATCACATCCTCTGATTGG	0.363000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			6	150					0	0	1	0	0
ZBTB24	9841	broad.mit.edu	37	6	109802512	109802512	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:109802512C>G	ENST00000230122.3	-	2	885	c.718G>C	c.(718-720)Gat>Cat	p.D240H		NM_001164313.1|NM_014797.2	NP_001157785.1|NP_055612.2	O43167	ZBT24_HUMAN	zinc finger and BTB domain containing 24	240					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|skin(1)|stomach(1)	22		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0154)|all cancers(137;0.0216)|OV - Ovarian serous cystadenocarcinoma(136;0.0242)|BRCA - Breast invasive adenocarcinoma(108;0.059)		GTCTTGGGATCATAGTTCTCA	0.453000													141	97					0	0	1	0	0
PARL	55486	broad.mit.edu	37	3	183560125	183560125	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:183560125G>C	ENST00000317096.4	-	6	778	c.718C>G	c.(718-720)Ctg>Gtg	p.L240V	PARL_ENST00000311101.5_Intron|PARL_ENST00000435888.1_Intron	NM_018622.5	NP_061092.3	Q9H300	PARL_HUMAN	presenilin associated, rhomboid-like	240					proteolysis	integral to membrane|mitochondrial inner membrane|nucleus	serine-type endopeptidase activity			endometrium(2)|large_intestine(3)|liver(1)|lung(6)|prostate(1)|skin(1)|stomach(2)|urinary_tract(1)	17	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.21e-41)|Epithelial(37;1.34e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TCTTGACCCAGAATGTTCACT	0.423000													10	236					0	0	1	0	0
PCNX	22990	broad.mit.edu	37	14	71568755	71568755	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr14:71568755G>A	ENST00000304743.2	+	31	6084	c.5638G>A	c.(5638-5640)Gaa>Aaa	p.E1880K	PCNX_ENST00000238570.5_Missense_Mutation_p.E1808K|PCNX_ENST00000439984.3_Missense_Mutation_p.E1769K|PCNX_ENST00000556272.1_3'UTR	NM_014982.2	NP_055797.2	Q96RV3	PCX1_HUMAN	pecanex homolog (Drosophila)	1880						integral to membrane				NS(2)|biliary_tract(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(14)|liver(2)|lung(40)|ovary(1)|prostate(7)|skin(2)|urinary_tract(1)	87			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		TGTGCTCTATGAAGCCATAGT	0.388000													56	9					0	0	1	0	0
TUBG2	27175	broad.mit.edu	37	17	40811902	40811902	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:40811902G>C	ENST00000251412.7	+	2	299	c.100G>C	c.(100-102)Gag>Cag	p.E34Q		NM_016437.2	NP_057521.1	Q9NRH3	TBG2_HUMAN	tubulin, gamma 2	34					G2/M transition of mitotic cell cycle|microtubule-based process|protein polymerization	cytosol	GTP binding|GTPase activity|structural molecule activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)	15		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.141)		TATCAGCCCCGAGGGCATCGT	0.652000													3	78					0	0	1	0	0
TXNDC16	57544	broad.mit.edu	37	14	52985902	52985902	+	Missense_Mutation	SNP	T	T	C	rs141505627		TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr14:52985902T>C	ENST00000281741.4	-	7	873	c.502A>G	c.(502-504)Att>Gtt	p.I168V	TXNDC16_ENST00000554399.1_Intron	NM_001160047.1|NM_020784.2	NP_001153519.1|NP_065835.2	Q9P2K2	TXD16_HUMAN	thioredoxin domain containing 16	168					cell redox homeostasis	extracellular region				breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|prostate(3)|skin(1)	21	Breast(41;0.0716)					GGTATTCCAATGGCTCTTACA	0.308000													5	43					0	0	1	0	0
MAGI2	9863	broad.mit.edu	37	7	77649123	77649123	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:77649123C>T	ENST00000354212.4	-	22	4130	c.3877G>A	c.(3877-3879)Gac>Aac	p.D1293N	MAGI2_ENST00000522391.1_3'UTR|MAGI2_ENST00000419488.1_Missense_Mutation_p.D1279N	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	1293						cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				TTCCTAACGTCGTGTTCCCGT	0.642000													6	126					0	0	1	0	0
MAPK13	5603	broad.mit.edu	37	6	36106508	36106508	+	Missense_Mutation	SNP	G	G	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:36106508G>T	ENST00000211287.4	+	10	1054	c.792G>T	c.(790-792)caG>caT	p.Q264H	MAPK13_ENST00000373761.6_Missense_Mutation_p.Q254H|MAPK13_ENST00000373766.5_Missense_Mutation_p.D214Y|MAPK13_ENST00000373759.1_Missense_Mutation_p.D136Y	NM_002754.4	NP_002745.1	O15264	MK13_HUMAN	mitogen-activated protein kinase 13	264	Protein kinase.				cell cycle|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|positive regulation of interleukin-6 production|Ras protein signal transduction|response to stress		ATP binding|MAP kinase activity|protein binding			breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(2)|prostate(2)|skin(1)	12						CCCTGCCACAGACCCCCAGGA	0.597000													12	27					4.93089e-13	5.24683e-13	1	1	0
RYR3	6263	broad.mit.edu	37	15	33936642	33936642	+	Missense_Mutation	SNP	G	G	A	rs35231209		TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr15:33936642G>A	ENST00000389232.4	+	28	3757	c.3687G>A	c.(3685-3687)atG>atA	p.M1229I	RYR3_ENST00000415757.3_Missense_Mutation_p.M1229I	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	1229	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CTGTCAACATGAACAGAGATG	0.488000													9	24					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76567029	76567029	+	Splice_Site	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:76567029C>G	ENST00000389840.5	-	6	1043		c.e6+1		DNAH17_ENST00000585328.1_Splice_Site					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TGCCTGCGCACCATCGTGAAG	0.473000													4	3					0	0	1	0	0
TRIM4	89122	broad.mit.edu	37	7	99490105	99490105	+	Missense_Mutation	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:99490105C>A	ENST00000355947.2	-	7	1313	c.1184G>T	c.(1183-1185)gGg>gTg	p.G395V	TRIM4_ENST00000349062.2_Missense_Mutation_p.G369V	NM_033017.3	NP_148977.2	Q9C037	TRIM4_HUMAN	tripartite motif containing 4	395	B30.2/SPRY.				protein trimerization	cytoplasm|plasma membrane	zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(1)	17	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)	Ovarian(593;0.238)				CCGACACACCCCAACAGCAAC	0.488000													10	288					2.17888e-05	2.22676e-05	1	1	0
B3GNT8	374907	broad.mit.edu	37	19	41932286	41932286	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:41932286C>G	ENST00000321702.2	-	3	851	c.398G>C	c.(397-399)gGa>gCa	p.G133A	B3GNT8_ENST00000601379.1_5'UTR	NM_198540.2	NP_940942.1	Q7Z7M8	B3GN8_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8	133	Poly-Gly.				poly-N-acetyllactosamine biosynthetic process|protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity|protein N-acetylglucosaminyltransferase activity			cervix(1)|kidney(2)|large_intestine(1)|lung(5)|prostate(2)	11						GCCACCACCTCCAGGCAGCCA	0.637000													35	54					0	0	1	0	0
MBD1	4152	broad.mit.edu	37	18	47803233	47803233	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr18:47803233C>T	ENST00000591416.1	-	4	792	c.361G>A	c.(361-363)Gac>Aac	p.D121N	MBD1_ENST00000588937.1_Missense_Mutation_p.D121N|MBD1_ENST00000587605.1_Missense_Mutation_p.D121N|MBD1_ENST00000382948.5_Missense_Mutation_p.D121N|MBD1_ENST00000585672.1_Missense_Mutation_p.D121N|MBD1_ENST00000269468.5_Missense_Mutation_p.D121N|MBD1_ENST00000591535.1_Missense_Mutation_p.D121N|MBD1_ENST00000457839.2_Missense_Mutation_p.D121N|MBD1_ENST00000590208.1_Missense_Mutation_p.D121N|MBD1_ENST00000349085.2_Missense_Mutation_p.D121N|MBD1_ENST00000339998.6_Missense_Mutation_p.D121N|MBD1_ENST00000353909.3_Missense_Mutation_p.D121N|MBD1_ENST00000398488.1_Missense_Mutation_p.D121N|MBD1_ENST00000269471.5_Missense_Mutation_p.D121N|MBD1_ENST00000585595.1_Missense_Mutation_p.D121N|MBD1_ENST00000347968.3_Missense_Mutation_p.D121N|MBD1_ENST00000424334.2_Missense_Mutation_p.D147N|MBD1_ENST00000398495.2_Missense_Mutation_p.D121N|MBD1_ENST00000398493.1_Missense_Mutation_p.D121N|MBD1_ENST00000436910.1_Missense_Mutation_p.D121N			Q9UIS9	MBD1_HUMAN	methyl-CpG binding domain protein 1	121					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|nuclear speck	methyl-CpG binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36						GGGGCTGTGTCAGTGTCAGCC	0.597000													6	156					0	0	1	0	0
IGLV2-8	28817	broad.mit.edu	37	22	23165548	23165548	+	RNA	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr22:23165548C>G	ENST00000390317.2	+	0	281																											GTCACCATCTCCTGCACTGGA	0.557000													113	285					0	0	1	0	0
ST6GALNAC1	55808	broad.mit.edu	37	17	74639591	74639591	+	Splice_Site	SNP	T	T	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:74639591T>G	ENST00000156626.7	-	1	329	c.130A>C	c.(130-132)Agg>Cgg	p.R44R	ST6GALNAC1_ENST00000590878.1_5'UTR|ST6GALNAC1_ENST00000589992.1_Splice_Site_p.R44R	NM_018414.3	NP_060884.1	Q9NSC7	SIA7A_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1	44					protein glycosylation	integral to Golgi membrane	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	22						GAATCTTACCTGGAAGGCTTT	0.488000													12	21					0	0	1	0	0
ZBTB22	9278	broad.mit.edu	37	6	33283128	33283128	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:33283128G>C	ENST00000431845.2	-	2	1717	c.1566C>G	c.(1564-1566)ttC>ttG	p.F522L	ZBTB22_ENST00000418724.1_Missense_Mutation_p.F522L	NM_005453.4	NP_005444.4	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	522					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(9)|ovary(2)|prostate(1)|urinary_tract(3)	21						GCTTCATCTTGAACTTTTTGT	0.552000													26	73					0	0	1	0	0
MOGS	7841	broad.mit.edu	37	2	74688503	74688503	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:74688503G>C	ENST00000233616.4	-	4	2575	c.2413C>G	c.(2413-2415)Ctt>Gtt	p.L805V	MOGS_ENST00000452063.2_Missense_Mutation_p.L699V|MOGS_ENST00000409065.1_3'UTR	NM_006302.2	NP_006293.2	Q13724	MOGS_HUMAN	mannosyl-oligosaccharide glucosidase	805					oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|membrane fraction	mannosyl-oligosaccharide glucosidase activity			cervix(1)|endometrium(6)|large_intestine(3)|lung(10)|prostate(1)|urinary_tract(2)	23						TGCTCCCAAAGAAAGCCTGTA	0.612000													3	66					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152784000	152784000	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:152784000C>T	ENST00000367255.5	-	20	2724	c.2123G>A	c.(2122-2124)aGa>aAa	p.R708K	SYNE1_ENST00000448038.1_Missense_Mutation_p.R715K|SYNE1_ENST00000466159.2_Missense_Mutation_p.R708K|SYNE1_ENST00000367253.4_Missense_Mutation_p.R708K|SYNE1_ENST00000367248.3_Missense_Mutation_p.R698K|SYNE1_ENST00000341594.5_Missense_Mutation_p.R715K|SYNE1_ENST00000413186.2_Missense_Mutation_p.R708K|SYNE1_ENST00000495090.2_Missense_Mutation_p.R275K|SYNE1_ENST00000423061.1_Missense_Mutation_p.R715K|SYNE1_ENST00000265368.4_Missense_Mutation_p.R708K	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	708					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTTCTTCATTCTGTCCATCTC	0.433000										HNSCC(10;0.0054)			29	26					0	0	1	0	0
MAGI1	9223	broad.mit.edu	37	3	65416426	65416426	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:65416426G>C	ENST00000330909.8	-	11	1493	c.1494C>G	c.(1492-1494)atC>atG	p.I498M	MAGI1_ENST00000470990.1_5'UTR|MAGI1_ENST00000483466.1_Missense_Mutation_p.I498M|MAGI1_ENST00000402939.2_Missense_Mutation_p.I498M|MAGI1_ENST00000497477.2_Missense_Mutation_p.I498M	NM_015520.1	NP_056335.1	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 1	498	PDZ 2.				cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|liver(1)|lung(21)|pancreas(1)|skin(5)	51		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		CCAAGCTCTTGATCTGGAGAA	0.498000													77	66					0	0	1	0	0
PCDHB1	29930	broad.mit.edu	37	5	140431107	140431107	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:140431107C>T	ENST00000306549.3	+	1	129	c.52C>T	c.(52-54)Ctc>Ttc	p.L18F		NM_013340.2	NP_037472.2	Q9Y5F3	PCDB1_HUMAN		18					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|liver(1)|lung(13)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	53			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGGATCTCTTCTCATTTTTCT	0.507000													12	52					0	0	1	0	0
ZNRD1-AS1	80862	broad.mit.edu	37	6	29977342	29977342	+	RNA	SNP	A	A	T	rs116382006	by1000genomes	TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:29977342A>T	ENST00000376797.3	-	0	731				ZNRD1-AS1_ENST00000448093.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA|HLA-J_ENST00000462773.1_RNA|ZNRD1-AS1_ENST00000420251.1_RNA																							TGGGACTGAGAGGCAAGATTT	0.438000													3	43					0	0	1	0	0
CEP76	79959	broad.mit.edu	37	18	12686364	12686364	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr18:12686364G>C	ENST00000262127.2	-	8	1244	c.1019C>G	c.(1018-1020)gCa>gGa	p.A340G	PSMG2_ENST00000585331.2_Intron|CEP76_ENST00000423709.2_Missense_Mutation_p.A265G|PSMG2_ENST00000589405.1_3'UTR	NM_024899.2	NP_079175.2	Q8TAP6	CEP76_HUMAN	centrosomal protein 76kDa	340					G2/M transition of mitotic cell cycle|regulation of centriole replication	centriole|cytosol	protein binding			endometrium(1)|kidney(3)|large_intestine(5)|lung(7)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						AACAAATCTTGCTGCTTGCCT	0.468000													41	71					0	0	1	0	0
KIF13B	23303	broad.mit.edu	37	8	28966972	28966972	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr8:28966972G>C	ENST00000524189.1	-	34	4178	c.4140C>G	c.(4138-4140)atC>atG	p.I1380M		NM_015254.3	NP_056069.2	Q9NQT8	KI13B_HUMAN	kinesin family member 13B	1380					microtubule-based movement|protein targeting|signal transduction|T cell activation	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein kinase binding			endometrium(6)|kidney(1)|lung(20)|urinary_tract(1)	28		Ovarian(32;0.000536)		KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)		TTGGAGAACTGATACTCCTCC	0.453000													73	11					0	0	1	0	0
SRR	63826	broad.mit.edu	37	17	2221223	2221223	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:2221223G>A	ENST00000344595.5	+	3	546	c.228G>A	c.(226-228)ccG>ccA	p.P76P	SRR_ENST00000576848.1_Intron	NM_021947.1	NP_068766.1	Q9GZT4	SRR_HUMAN	serine racemase	76					D-serine biosynthetic process|L-serine metabolic process|protein homotetramerization|pyruvate biosynthetic process|response to lipopolysaccharide	cytoplasm|neuronal cell body|soluble fraction	ATP binding|calcium ion binding|D-serine ammonia-lyase activity|glycine binding|L-serine ammonia-lyase activity|magnesium ion binding|PDZ domain binding|protein homodimerization activity|pyridoxal phosphate binding|serine racemase activity|threonine racemase activity			NS(1)|large_intestine(3)|lung(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	8		Colorectal(1115;3.46e-05)|Myeloproliferative disorder(207;0.0255)		COAD - Colon adenocarcinoma(228;3.24e-06)|READ - Rectum adenocarcinoma(1115;0.0649)	L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	AAAGGAAGCCGAAAGCTGTTG	0.443000													70	8					0	0	1	0	0
F11	2160	broad.mit.edu	37	4	187197540	187197540	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:187197540C>G	ENST00000264692.4	+	7	928	c.595C>G	c.(595-597)Caa>Gaa	p.Q199E	F11_ENST00000403665.2_Missense_Mutation_p.Q251E			P03951	FA11_HUMAN	coagulation factor XI	251					blood coagulation, intrinsic pathway|plasminogen activation|positive regulation of fibrinolysis	extracellular space|plasma membrane	heparin binding|serine-type endopeptidase activity			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(15)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	32		all_cancers(14;6.2e-52)|all_epithelial(14;1.62e-38)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;2.13e-11)|BRCA - Breast invasive adenocarcinoma(30;4.59e-06)|GBM - Glioblastoma multiforme(59;0.000149)|STAD - Stomach adenocarcinoma(60;0.000314)|LUSC - Lung squamous cell carcinoma(40;0.00112)|READ - Rectum adenocarcinoma(43;0.176)	Coagulation Factor IX(DB00100)	CAAAGAATCTCAAAGGTAAGG	0.368000													48	58					0	0	1	0	0
CNNM2	54805	broad.mit.edu	37	10	104678762	104678762	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr10:104678762C>G	ENST00000369878.4	+	1	713	c.525C>G	c.(523-525)atC>atG	p.I175M	CNNM2_ENST00000433628.2_Missense_Mutation_p.I175M|CNNM2_ENST00000369875.3_Missense_Mutation_p.I175M	NM_017649.4	NP_060119.3	Q9H8M5	CNNM2_HUMAN	cyclin M2						ion transport	integral to membrane				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|urinary_tract(1)	19		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		TCATCGAGATCGAGATCAAAC	0.637000													12	288					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141004700	141004700	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:141004700C>T	ENST00000389484.3	-	87	14250	c.13279G>A	c.(13279-13281)Gaa>Aaa	p.E4427K		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	4427	EGF-like 14.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GCTGGCCTTTCACACTGTGTG	0.388000										TSP Lung(27;0.18)			35	20					0	0	1	0	0
USP29	57663	broad.mit.edu	37	19	57641057	57641057	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:57641057G>A	ENST00000254181.4	+	4	1468	c.1014G>A	c.(1012-1014)ttG>ttA	p.L338L	USP29_ENST00000598197.1_Silent_p.L338L	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	338					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TGCTTGCTTTGAAAGATTTCT	0.383000													4	93					0	0	1	0	0
FAM83G	644815	broad.mit.edu	37	17	18907093	18907093	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:18907093G>C	ENST00000388995.6	-	2	485	c.262C>G	c.(262-264)Cag>Gag	p.Q88E	SLC5A10_ENST00000395645.3_Intron|SLC5A10_ENST00000317977.6_Intron|FAM83G_ENST00000345041.4_Missense_Mutation_p.Q88E|SLC5A10_ENST00000417251.2_Intron|SLC5A10_ENST00000395643.2_Intron|FAM83G_ENST00000585154.2_Missense_Mutation_p.Q88E|SLC5A10_ENST00000395647.2_Intron|SLC5A10_ENST00000395642.1_Intron			A6ND36	FA83G_HUMAN	family with sequence similarity 83, member G	88										central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(7)|ovary(2)|prostate(3)|stomach(1)	22						TCGGGCCCCTGAGAGGGGCCC	0.701000													15	1					0	0	1	0	0
TTC26	79989	broad.mit.edu	37	7	138845756	138845756	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:138845756C>T	ENST00000464848.1	+	8	860	c.780C>T	c.(778-780)atC>atT	p.I260I	TTC26_ENST00000478836.2_Silent_p.I154I|TTC26_ENST00000474035.2_Silent_p.I260I|TTC26_ENST00000495038.1_Intron|TTC26_ENST00000430935.1_Silent_p.I260I|TTC26_ENST00000343187.4_Silent_p.I229I|TTC26_ENST00000481482.1_3'UTR			A0AVF1	TTC26_HUMAN	tetratricopeptide repeat domain 26	260							binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	24						AAGAACTCATCAGGCACAATC	0.373000													14	5					0	0	1	0	0
TRIM72	493829	broad.mit.edu	37	16	31230742	31230742	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr16:31230742C>G	ENST00000322122.3	+	4	903	c.619C>G	c.(619-621)Cgg>Ggg	p.R207G		NM_001008274.3	NP_001008275.2	Q6ZMU5	TRI72_HUMAN	tripartite motif containing 72	207					exocytosis|muscle organ development|muscle system process|plasma membrane repair|protein homooligomerization	cytoplasmic vesicle membrane|sarcolemma	phosphatidylserine binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(2)|lung(9)|skin(1)	15						CGCCTTGCGCCGGGAGCTGGG	0.657000													5	154					0	0	1	0	0
PKD1L1	168507	broad.mit.edu	37	7	47955030	47955030	+	Splice_Site	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:47955030G>A	ENST00000289672.2	-	8	1277	c.1227C>T	c.(1225-1227)acC>acT	p.T409T		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	409					cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						aaaacatactggtgacaaagg	0.388000													4	77					0	0	1	0	0
GAD1	2571	broad.mit.edu	37	2	171713567	171713567	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:171713567G>A	ENST00000358196.3	+	15	2003	c.1453G>A	c.(1453-1455)Gaa>Aaa	p.E485K		NM_000817.2	NP_000808.2	Q99259	DCE1_HUMAN	glutamate decarboxylase 1 (brain, 67kDa)	485					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion|protein-pyridoxal-5-phosphate linkage	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|plasma membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(15)|ovary(1)|urinary_tract(2)	35					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	CAAATGCCTGGAACTGGCTGA	0.413000													87	155					0	0	1	0	0
TSPAN12	23554	broad.mit.edu	37	7	120428740	120428740	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:120428740G>A	ENST00000222747.3	-	8	1431	c.824C>T	c.(823-825)tCa>tTa	p.S275L	TSPAN12_ENST00000415871.1_Missense_Mutation_p.S275L	NM_012338.3	NP_036470.1	O95859	TSN12_HUMAN	tetraspanin 12	275					angiogenesis|cell surface receptor linked signaling pathway|regulation of angiogenesis|retina layer formation	integral to plasma membrane|membrane fraction				endometrium(3)|kidney(1)|lung(4)|ovary(1)|skin(1)	10	all_neural(327;0.117)					CAGTTCTACTGAGGGACATGA	0.428000													91	15					0	0	1	0	0
UBAP2L	9898	broad.mit.edu	37	1	154228194	154228194	+	Nonsense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:154228194C>G	ENST00000428931.1	+	18	2287	c.2120C>G	c.(2119-2121)tCa>tGa	p.S707*	UBAP2L_ENST00000271877.7_Nonsense_Mutation_p.S718*|UBAP2L_ENST00000361546.2_Nonsense_Mutation_p.S707*|UBAP2L_ENST00000343815.6_Nonsense_Mutation_p.S707*	NM_014847.3	NP_055662.3	Q14157	UBP2L_HUMAN	ubiquitin associated protein 2-like	707					binding of sperm to zona pellucida		protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(20)|ovary(1)|prostate(1)|urinary_tract(2)	50	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CTTTCATCATCAACATCTTCT	0.453000													10	111					0	0	1	0	0
CCDC36	339834	broad.mit.edu	37	3	49274119	49274119	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:49274119G>A	ENST00000438782.1	+	3	431	c.195G>A	c.(193-195)ttG>ttA	p.L65L	CCDC36_ENST00000366429.2_Silent_p.L65L|CCDC36_ENST00000296449.5_Silent_p.L65L|CCDC36_ENST00000452691.2_Silent_p.L65L|CCDC36_ENST00000451634.2_Silent_p.L55L			Q8IYA8	CCD36_HUMAN	coiled-coil domain containing 36	65										endometrium(1)|kidney(2)|large_intestine(3)|liver(1)|lung(3)|ovary(1)|urinary_tract(3)	14				BRCA - Breast invasive adenocarcinoma(193;9.11e-05)|Kidney(197;0.00248)|KIRC - Kidney renal clear cell carcinoma(197;0.00262)		GTGCCCACTTGAGACATTCAA	0.413000													35	32					0	0	1	0	0
RGPD4	285190	broad.mit.edu	37	2	108487281	108487281	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:108487281C>T	ENST00000408999.3	+	20	2898	c.2821C>T	c.(2821-2823)Ctt>Ttt	p.L941F	RGPD4_ENST00000354986.4_Missense_Mutation_p.L941F	NM_182588.2	NP_872394.2	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	941					intracellular transport		binding			breast(1)|endometrium(7)|kidney(4)|lung(23)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(3)	43						TGAAAAGCCTCTTGAAAATGA	0.413000													165	109					0	0	1	0	0
AC015849.16	0	broad.mit.edu	37	17	34236398	34236398	+	RNA	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:34236398G>C	ENST00000587132.1	-	0	1629																											TCCAGAGGTTGAACTGTAACG	0.478000													20	50					0	0	1	0	0
SIMC1	375484	broad.mit.edu	37	5	175716740	175716740	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:175716740G>C	ENST00000443967.1	+	4	563	c.156G>C	c.(154-156)gaG>gaC	p.E52D	SIMC1_ENST00000341199.6_Intron|SIMC1_ENST00000430704.2_Intron|SIMC1_ENST00000503595.1_3'UTR|SIMC1_ENST00000429602.2_Missense_Mutation_p.E71D					SUMO-interacting motifs containing 1																		CAAGAGCTGAGGGAGAAAATA	0.463000													3	20					0	0	1	0	0
FN1	2335	broad.mit.edu	37	2	216279564	216279564	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:216279564C>G	ENST00000354785.4	-	13	2306	c.1937G>C	c.(1936-1938)aGa>aCa	p.R646T	FN1_ENST00000359671.1_Missense_Mutation_p.R646T|FN1_ENST00000356005.4_Missense_Mutation_p.R646T|FN1_ENST00000345488.5_Missense_Mutation_p.R646T|FN1_ENST00000346544.3_Missense_Mutation_p.R646T|FN1_ENST00000336916.4_Missense_Mutation_p.R646T|FN1_ENST00000357009.2_Missense_Mutation_p.R646T|FN1_ENST00000446046.1_Missense_Mutation_p.R646T|FN1_ENST00000443816.1_Missense_Mutation_p.R646T|FN1_ENST00000323926.6_Missense_Mutation_p.R646T|FN1_ENST00000432072.2_Missense_Mutation_p.R646T|FN1_ENST00000426059.1_Missense_Mutation_p.R646T|FN1_ENST00000421182.1_Missense_Mutation_p.R646T|FN1_ENST00000357867.4_Missense_Mutation_p.R646T			P02751	FINC_HUMAN	fibronectin 1	646	Fibronectin type-III 1.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding		FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACTCACAGGTCTCCACCTGAG	0.463000													16	9					0	0	1	0	0
CASC5	57082	broad.mit.edu	37	15	40920274	40920274	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr15:40920274G>C	ENST00000346991.5	+	12	5851	c.5461G>C	c.(5461-5463)Gat>Cat	p.D1821H	CASC5_ENST00000399668.2_Missense_Mutation_p.D1795H			Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5	1821					acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			NS(1)|breast(7)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(13)|lung(16)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		TCAGATTTTTGATCACCATAC	0.328000													20	50					0	0	1	0	0
CDK16	5127	broad.mit.edu	37	X	47083822	47083822	+	Nonsense_Mutation	SNP	G	G	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chrX:47083822G>T	ENST00000457458.2	+	3	679	c.259G>T	c.(259-261)Gag>Tag	p.E87*	CDK16_ENST00000276052.6_Nonsense_Mutation_p.E155*|CDK16_ENST00000518022.1_Nonsense_Mutation_p.E81*|CDK16_ENST00000357227.4_Nonsense_Mutation_p.E81*	NM_033018.3	NP_148978.2	Q00536	CDK16_HUMAN	cyclin-dependent kinase 16	81							ATP binding|cyclin-dependent protein kinase activity|protein binding			breast(1)|endometrium(3)|large_intestine(4)|lung(3)	11						GTCTGATGGGGAGAGTGACCA	0.607000													4	35					1.23904e-05	1.26766e-05	1	1	0
PCDHGA9	56107	broad.mit.edu	37	5	140783957	140783957	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:140783957G>A	ENST00000573521.1	+	1	1438	c.1438G>A	c.(1438-1440)Gat>Aat	p.D480N	PCDHGA4_ENST00000571252.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA8_ENST00000398604.2_Intron	NM_018921.2|NM_032089.1	NP_061744.1|NP_114478.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTATGACCCTGATAGCAATGA	0.468000													15	48					0	0	1	0	0
QPCT	25797	broad.mit.edu	37	2	37586728	37586728	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:37586728C>G	ENST00000338415.3	+	3	431	c.273C>G	c.(271-273)atC>atG	p.I91M	QPCT_ENST00000537448.1_Missense_Mutation_p.I42M	NM_012413.3	NP_036545.1	Q16769	QPCT_HUMAN	glutaminyl-peptide cyclotransferase	91					peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase|proteolysis	extracellular region	acyltransferase activity|glutaminyl-peptide cyclotransferase activity|peptidase activity|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(3)|prostate(1)|stomach(2)	17		Ovarian(717;0.051)|all_hematologic(82;0.21)				ATCAGCACATCATGCAGCGAA	0.368000													3	43					0	0	1	0	0
TTF2	8458	broad.mit.edu	37	1	117618442	117618442	+	Silent	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:117618442C>A	ENST00000369466.4	+	5	1280	c.1236C>A	c.(1234-1236)gcC>gcA	p.A412A		NM_003594.3	NP_003585.3	Q9UNY4	TTF2_HUMAN	transcription termination factor, RNA polymerase II						mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|termination of RNA polymerase II transcription	cytoplasm|spliceosomal complex|transcription elongation factor complex	ATP binding|ATP-dependent helicase activity|DNA binding|DNA-dependent ATPase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(1)|lung(24)|ovary(1)|prostate(2)|skin(2)|urinary_tract(2)	50	Lung SC(450;0.225)	all_cancers(81;4.23e-06)|all_epithelial(167;3.65e-07)|all_lung(203;2.81e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0553)|Colorectal(144;0.179)|LUSC - Lung squamous cell carcinoma(189;0.19)		ACCCAGTAGCCCGGCGTGTCT	0.463000													20	43					8.34094e-07	8.64779e-07	1	1	0
LOC643201	643201	broad.mit.edu	37	5	175581818	175581818	+	RNA	SNP	G	G	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:175581818G>T	ENST00000515403.1	-	0	2257				RP11-826N14.4_ENST00000510029.1_lincRNA	NR_036494.1																						GAATGCACAGGAAAAGGCTTC	0.473000													3	9					0.004672	0.00470743	1	1	0
AFF3	3899	broad.mit.edu	37	2	100209920	100209920	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:100209920C>T	ENST00000409236.2	-	13	2315	c.2203G>A	c.(2203-2205)Gcc>Acc	p.A735T	AFF3_ENST00000409579.1_Missense_Mutation_p.A760T|AFF3_ENST00000317233.4_Missense_Mutation_p.A735T|AFF3_ENST00000356421.2_Missense_Mutation_p.A760T			P51826	AFF3_HUMAN	AF4/FMR2 family, member 3						multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						AGCTCCTTGGCGATGTCACTG	0.597000													10	88					0	0	1	0	0
ESPL1	9700	broad.mit.edu	37	12	53676066	53676066	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:53676066C>G	ENST00000257934.4	+	14	2729	c.2638C>G	c.(2638-2640)Ctg>Gtg	p.L880V	ESPL1_ENST00000552462.1_Missense_Mutation_p.L880V	NM_012291.4	NP_036423.4	Q14674	ESPL1_HUMAN	extra spindle pole bodies homolog 1 (S. cerevisiae)	880					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(10)|large_intestine(12)|lung(21)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(8)	70						GGGTGTCTCTCTGCTGCTGTC	0.592000													38	81					0	0	1	0	0
EAPP	55837	broad.mit.edu	37	14	34985644	34985644	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr14:34985644C>G	ENST00000250454.3	-	6	811	c.730G>C	c.(730-732)Gag>Cag	p.E244Q		NM_018453.3	NP_060923.2	Q56P03	EAPP_HUMAN	E2F-associated phosphoprotein	244					negative regulation of transcription elongation from RNA polymerase II promoter|positive regulation of cell proliferation|positive regulation of transcription elongation from RNA polymerase II promoter	Golgi apparatus|nucleus|plasma membrane				breast(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|urinary_tract(2)	12	Breast(36;0.0473)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00342)|Epithelial(34;0.18)	GBM - Glioblastoma multiforme(112;0.0196)		TCTGCCTTCTCGGCAGCATCT	0.443000													11	128					0	0	1	0	0
SEMA4C	54910	broad.mit.edu	37	2	97532106	97532106	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:97532106G>A	ENST00000305476.5	-	3	304	c.172C>T	c.(172-174)Ctg>Ttg	p.L58L		NM_017789.4	NP_060259.4	Q9C0C4	SEM4C_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C	58	Dominant negative effect on myogenic differentiation (By similarity).|Sema.				muscle cell differentiation|nervous system development|positive regulation of stress-activated MAPK cascade	cell junction|integral to membrane|postsynaptic density|postsynaptic membrane|synaptic vesicle membrane	receptor activity			NS(1)|kidney(1)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	17						GGCTCCGTCAGCGTCAGTGTC	0.657000													6	94					0	0	1	0	0
NUP93	9688	broad.mit.edu	37	16	56872905	56872905	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr16:56872905C>T	ENST00000564887.1	+	17	2320	c.1691C>T	c.(1690-1692)tCc>tTc	p.S564F	NUP93_ENST00000542526.1_Missense_Mutation_p.S564F|NUP93_ENST00000308159.5_Missense_Mutation_p.S687F|NUP93_ENST00000569842.1_Missense_Mutation_p.S687F	NM_001242795.1	NP_001229724.1	Q8N1F7	NUP93_HUMAN	nucleoporin 93kDa	687					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(2)|endometrium(6)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27						TTTGTGGACTCCACGTTCTAT	0.393000													85	167					0	0	1	0	0
FSIP2	401024	broad.mit.edu	37	2	186673357	186673357	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:186673357G>A	ENST00000343098.5	+	17	19591	c.19591G>A	c.(19591-19593)Gat>Aat	p.D6531N	FSIP2_ENST00000424728.1_Missense_Mutation_p.D6442N	NM_173651.2	NP_775922.2			fibrous sheath interacting protein 2											NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(11)|lung(46)|pancreas(1)|urinary_tract(2)	69						ATTTTATTATGATATAAAAGA	0.294000													8	30					0	0	1	0	0
CCDC108	255101	broad.mit.edu	37	2	219868984	219868984	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:219868984C>G	ENST00000341552.5	-	33	5328	c.5245G>C	c.(5245-5247)Gac>Cac	p.D1749H	AC097468.4_ENST00000441450.1_RNA|CCDC108_ENST00000453220.1_Missense_Mutation_p.D1749H|CCDC108_ENST00000441968.1_Missense_Mutation_p.D1749H	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	1749						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCTGGTCTGTCTTCCTTCGGC	0.527000													5	108					0	0	1	0	0
PRLHR	2834	broad.mit.edu	37	10	120354301	120354301	+	Silent	SNP	G	G	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr10:120354301G>T	ENST00000239032.2	-	2	594	c.456C>A	c.(454-456)ctC>ctA	p.L152L	PRLHR_ENST00000369169.1_Silent_p.L152L	NM_004248.2	NP_004239	P49683	PRLHR_HUMAN	prolactin releasing hormone receptor	152					female pregnancy	integral to plasma membrane	neuropeptide Y receptor activity			large_intestine(2)|lung(8)|ovary(1)|skin(1)	12		Colorectal(252;0.0429)|Lung NSC(174;0.142)|all_lung(145;0.175)		all cancers(201;0.0166)		CGATGGTGGTGAGCGTGAACA	0.677000													18	23					1.56452e-12	1.65907e-12	1	1	0
POTEF	728378	broad.mit.edu	37	2	130832564	130832564	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:130832564G>A	ENST00000357462.5	-	15	2574	c.2481C>T	c.(2479-2481)ttC>ttT	p.F827F	POTEF_ENST00000409914.2_Silent_p.F827F			A5A3E0	POTEF_HUMAN	POTE ankyrin domain family, member F	827	Actin-like.					cell cortex	ATP binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(28)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	53						CTGGGGTGTTGAAGGTCTCAA	0.612000													6	326					0	0	1	0	0
MAN2C1	4123	broad.mit.edu	37	15	75656927	75656927	+	Nonsense_Mutation	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr15:75656927C>A	ENST00000565683.1	-	5	513	c.502G>T	c.(502-504)Gag>Tag	p.E168*	MAN2C1_ENST00000563539.1_5'UTR|MAN2C1_ENST00000569482.1_Nonsense_Mutation_p.E168*|MAN2C1_ENST00000267978.5_Nonsense_Mutation_p.E168*|MAN2C1_ENST00000563622.1_Nonsense_Mutation_p.E168*	NM_001256494.1	NP_001243423.1	Q9NTJ4	MA2C1_HUMAN	mannosidase, alpha, class 2C, member 1	168					mannose metabolic process		alpha-mannosidase activity|carbohydrate binding|protein binding|zinc ion binding			central_nervous_system(4)|endometrium(4)|kidney(6)|large_intestine(6)|lung(20)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	44						AACATCTTCTCAGGGTCAGGG	0.592000													17	10					1.02788e-11	1.08876e-11	1	1	0
ORAI3	93129	broad.mit.edu	37	16	30960832	30960832	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr16:30960832C>T	ENST00000318663.4	+	1	446	c.222C>T	c.(220-222)ttC>ttT	p.F74F	ORAI3_ENST00000562699.1_Silent_p.F74F|AC135048.13_ENST00000566056.1_RNA|ORAI3_ENST00000566237.1_Silent_p.F74F	NM_152288.2	NP_689501.1	Q9BRQ5	ORAI3_HUMAN	ORAI calcium release-activated calcium modulator 3	74						integral to membrane	protein binding			endometrium(1)|large_intestine(1)|lung(2)|prostate(1)|skin(1)	6						TCTCGGGCTTCGCCATGGTGA	0.692000													9	8					0	0	1	0	0
DRD2	1813	broad.mit.edu	37	11	113286178	113286178	+	Nonsense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:113286178G>A	ENST00000362072.3	-	5	1032	c.688C>T	c.(688-690)Cga>Tga	p.R230*	DRD2_ENST00000535984.1_5'UTR|DRD2_ENST00000542968.1_Nonsense_Mutation_p.R230*|DRD2_ENST00000355319.2_Nonsense_Mutation_p.R230*|DRD2_ENST00000544518.1_Nonsense_Mutation_p.R229*|DRD2_ENST00000346454.3_Nonsense_Mutation_p.R230*|DRD2_ENST00000538967.1_Nonsense_Mutation_p.R230*	NM_000795.3	NP_000786.1	P14416	DRD2_HUMAN	dopamine receptor D2	230	Interaction with PPP1R9B (By similarity).				activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(18)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	39		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	CTGAAAGCTCGGCTGCTGCGT	0.562000													5	126					0	0	1	0	0
SESTD1	91404	broad.mit.edu	37	2	179997075	179997075	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:179997075G>C	ENST00000428443.3	-	10	1244	c.928C>G	c.(928-930)Cag>Gag	p.Q310E		NM_178123.4	NP_835224.3	Q86VW0	SESD1_HUMAN	SEC14 and spectrin domains 1	310					regulation of calcium ion transport via voltage-gated calcium channel activity		phosphatidic acid binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding|protein binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(3)	30			OV - Ovarian serous cystadenocarcinoma(117;0.0344)|Epithelial(96;0.0531)|all cancers(119;0.147)			TGTAGGGCCTGGGAGGCCCTA	0.468000													9	274					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237843838	237843838	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:237843838G>A	ENST00000366574.2	+	62	9295	c.8978G>A	c.(8977-8979)gGa>gAa	p.G2993E	RYR2_ENST00000360064.6_Missense_Mutation_p.G2991E|RYR2_ENST00000542537.1_Missense_Mutation_p.G2977E|RYR2_ENST00000609119.1_3'UTR	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	2993	Modulator (Potential).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CTCTGCTCTGGAGGACATGCT	0.373000													11	13					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215882852	215882852	+	Missense_Mutation	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:215882852C>A	ENST00000272895.7	-	14	1881	c.1662G>T	c.(1660-1662)caG>caT	p.Q554H	ABCA12_ENST00000389661.4_Missense_Mutation_p.Q236H	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	554					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TTTCTAGTAACTGACCTGCAA	0.363000													12	9					3.07112e-06	3.16997e-06	1	1	0
PDCD6IP	10015	broad.mit.edu	37	3	33907982	33907982	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:33907982C>G	ENST00000307296.3	+	18	2949	c.2572C>G	c.(2572-2574)Cag>Gag	p.Q858E	PDCD6IP_ENST00000457054.2_Missense_Mutation_p.Q863E			Q8WUM4	PDC6I_HUMAN	programmed cell death 6 interacting protein	858	Interaction with EIAV p9.|Pro-rich.|Self-association.				apoptosis|cell cycle|cell division|interspecies interaction between organisms|protein transport	cytosol|melanosome|microtubule organizing center	calcium-dependent protein binding			central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|skin(1)|stomach(1)	23						CCCCTTCCCTCAGCCCCCACA	0.512000													64	76					0	0	1	0	0
SCMH1	22955	broad.mit.edu	37	1	41579108	41579108	+	Missense_Mutation	SNP	T	T	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:41579108T>A	ENST00000402904.2	-	8	930	c.562A>T	c.(562-564)Act>Tct	p.T188S	SCMH1_ENST00000397174.2_Missense_Mutation_p.T168S|SCMH1_ENST00000372597.1_Missense_Mutation_p.T141S|SCMH1_ENST00000361191.5_Missense_Mutation_p.T127S|SCMH1_ENST00000361705.3_Missense_Mutation_p.T141S|SCMH1_ENST00000456518.2_Intron|SCMH1_ENST00000326197.7_Missense_Mutation_p.T188S|SCMH1_ENST00000372595.1_Missense_Mutation_p.T127S|SCMH1_ENST00000372596.1_Missense_Mutation_p.T127S|SCMH1_ENST00000337495.5_Missense_Mutation_p.T198S|SCMH1_ENST00000397171.2_Missense_Mutation_p.T127S	NM_001031694.2	NP_001026864.1	Q96GD3	SCMH1_HUMAN	sex comb on midleg homolog 1 (Drosophila)	188					anatomical structure morphogenesis|gene silencing|multicellular organismal development|negative regulation of transcription, DNA-dependent		DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(2)|pancreas(2)|upper_aerodigestive_tract(1)	15	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)|Breast(333;0.162)	Myeloproliferative disorder(586;0.0393)				TCCCCAATAGTGGCTGGGCAA	0.537000													75	45					0	0	1	0	0
CCNJL	79616	broad.mit.edu	37	5	159686479	159686479	+	Nonsense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:159686479G>A	ENST00000393977.3	-	5	1009	c.724C>T	c.(724-726)Caa>Taa	p.Q242*	CCNJL_ENST00000541762.1_Nonsense_Mutation_p.Q193*|CCNJL_ENST00000377503.2_5'UTR|CCNJL_ENST00000257536.7_Nonsense_Mutation_p.Q194*|CCNJL_ENST00000519673.1_Nonsense_Mutation_p.Q194*	NM_024565.5	NP_078841.3	Q8IV13	CCNJL_HUMAN	cyclin J-like	242						nucleus				endometrium(2)|kidney(5)|large_intestine(2)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	17	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTGTCACCTTGCAGGGTGACC	0.622000													14	25					0	0	1	0	0
C8orf37	157657	broad.mit.edu	37	8	96281387	96281387	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr8:96281387C>T	ENST00000286688.5	-	1	42	c.31G>A	c.(31-33)Gaa>Aaa	p.E11K	KB-1047C11.2_ENST00000521905.1_lincRNA	NM_177965.3	NP_808880.1	Q96NL8	CH037_HUMAN	chromosome 8 open reading frame 37	11										kidney(1)|large_intestine(1)|lung(5)	7	Breast(36;3.41e-05)					GACTCGACTTCATCCAAGAGC	0.602000											OREG0018873	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	406					0	0	1	0	0
ZKSCAN1	7586	broad.mit.edu	37	7	99631580	99631580	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:99631580G>A	ENST00000324306.6	+	6	1686	c.1452G>A	c.(1450-1452)acG>acA	p.T484T	ZKSCAN1_ENST00000535170.1_Silent_p.T271T|ZKSCAN1_ENST00000426572.1_Silent_p.T448T	NM_003439.1	NP_003430.1	P17029	ZKSC1_HUMAN	zinc finger with KRAB and SCAN domains 1	484					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.T484T(1)		breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(5)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			GAATTCACACGGGGGAGAAAC	0.473000													7	149					0	0	1	0	0
BLNK	29760	broad.mit.edu	37	10	98031128	98031128	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr10:98031128G>A	ENST00000224337.5	-	1	169	c.28C>T	c.(28-30)Ccc>Tcc	p.P10S	BLNK_ENST00000371176.2_Missense_Mutation_p.P10S|BLNK_ENST00000495266.1_Missense_Mutation_p.P10S|BLNK_ENST00000413476.2_Missense_Mutation_p.P10S|BLNK_ENST00000427367.2_Missense_Mutation_p.P10S	NM_013314.3	NP_037446.1	Q8WV28	BLNK_HUMAN	B-cell linker	10					B cell differentiation|humoral immune response|inflammatory response|intracellular signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity|transmembrane receptor protein tyrosine kinase adaptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|skin(2)|stomach(1)	14		Colorectal(252;0.083)		Epithelial(162;7.89e-08)|all cancers(201;2.27e-06)		TGACTGGCGGGGACGGTTATT	0.458000													51	57					0	0	1	0	0
APCDD1L	164284	broad.mit.edu	37	20	57045726	57045726	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr20:57045726C>G	ENST00000371149.3	-	2	357	c.127G>C	c.(127-129)Gat>Cat	p.D43H	APCDD1L_ENST00000439429.1_Missense_Mutation_p.D54H	NM_153360.1	NP_699191.1	Q8NCL9	APCDL_HUMAN	adenomatosis polyposis coli down-regulated 1-like	43						integral to membrane				large_intestine(8)|lung(7)|ovary(1)|prostate(1)|skin(1)	18	Lung NSC(12;0.000856)|all_lung(29;0.0025)		BRCA - Breast invasive adenocarcinoma(13;5.6e-11)|Epithelial(14;1.67e-07)|all cancers(14;1.48e-06)			GGCACTCTATCTGGCAAGGGC	0.637000													2	2					0	0	1	0	0
NFXL1	152518	broad.mit.edu	37	4	47912912	47912912	+	Missense_Mutation	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:47912912C>A	ENST00000507489.1	-	3	511	c.335G>T	c.(334-336)gGa>gTa	p.G112V	NFXL1_ENST00000329043.3_Missense_Mutation_p.G112V|NFXL1_ENST00000381538.3_Missense_Mutation_p.G112V	NM_001278624.1	NP_001265553.1	Q6ZNB6	NFXL1_HUMAN	nuclear transcription factor, X-box binding-like 1	112						integral to membrane|nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(4)	27						ATCTTCATCTCCTTCTTCAGA	0.338000													16	17					2.23348e-06	2.30793e-06	1	1	0
MYH7	4625	broad.mit.edu	37	14	23893277	23893277	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr14:23893277C>T	ENST00000355349.3	-	23	2923	c.2761G>A	c.(2761-2763)Gag>Aag	p.E921K		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	921			E -> K (in CMH1).		adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TCGTTCATCTCCTTCACCTTG	0.517000													68	13					0	0	1	0	0
PRELP	5549	broad.mit.edu	37	1	203452885	203452885	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:203452885C>G	ENST00000343110.2	+	2	700	c.573C>G	c.(571-573)ttC>ttG	p.F191L		NM_002725.3|NM_201348.1	NP_002716.1|NP_958505.1	P51888	PRELP_HUMAN	proline/arginine-rich end leucine-rich repeat protein	191					skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			BRCA - Breast invasive adenocarcinoma(75;0.109)			CTGGTGTCTTCAGCAAGCTGG	0.602000													7	149					0	0	1	0	0
DENND4A	10260	broad.mit.edu	37	15	66031159	66031159	+	Missense_Mutation	SNP	G	G	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr15:66031159G>T	ENST00000443035.3	-	6	901	c.686C>A	c.(685-687)tCt>tAt	p.S229Y	DENND4A_ENST00000431932.2_Missense_Mutation_p.S229Y	NM_001144823.1	NP_001138295.1	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A	229	UDENN.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(11)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	51						TAGAGGAACAGATTCCGGTAG	0.343000													23	43					1.9806e-07	2.06729e-07	1	1	0
DUSP13	51207	broad.mit.edu	37	10	76854451	76854451	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr10:76854451C>G	ENST00000491677.2	-	8	1509	c.967G>C	c.(967-969)Gag>Cag	p.E323Q	DUSP13_ENST00000372702.3_3'UTR|DUSP13_ENST00000607131.1_Missense_Mutation_p.E287Q|DUSP13_ENST00000478873.2_Missense_Mutation_p.E330Q|DUSP13_ENST00000605915.1_Missense_Mutation_p.E216Q|DUSP13_ENST00000372700.3_Missense_Mutation_p.E244Q|DUSP13_ENST00000464872.1_Missense_Mutation_p.E143Q|DUSP13_ENST00000472493.2_Missense_Mutation_p.E194Q	NM_001007271.1	NP_001007272.1	Q6B8I1	MDSP_HUMAN	dual specificity phosphatase 13	0						cytoplasm	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			large_intestine(3)|lung(3)|prostate(1)|urinary_tract(1)	8	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					CGCCCCGTCTCCCGCCCCAGT	0.642000													19	28					0	0	1	0	0
PDP2	57546	broad.mit.edu	37	16	66919441	66919441	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr16:66919441G>A	ENST00000311765.2	+	2	1588	c.1254G>A	c.(1252-1254)ctG>ctA	p.L418L	PDP2_ENST00000568720.1_Intron	NM_020786.2	NP_065837.1	Q9P2J9	PDP2_HUMAN	pyruvate dehyrogenase phosphatase catalytic subunit 2	418					pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix|protein serine/threonine phosphatase complex	[pyruvate dehydrogenase (lipoamide)] phosphatase activity|metal ion binding			kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|urinary_tract(1)	12		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.088)|Epithelial(162;0.204)		GGGACATGCTGAGCAATGAGG	0.607000													5	130					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169463518	169463518	+	Splice_Site	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:169463518G>C	ENST00000256935.8	+	36	3704		c.e36-1		DOCK2_ENST00000520908.1_Splice_Site|DOCK2_ENST00000523351.1_Splice_Site|DOCK2_ENST00000540750.1_Splice_Site	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2						actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCCCTACCTAGAATTTCTACA	0.408000													38	27					0	0	1	0	0
L2HGDH	79944	broad.mit.edu	37	14	50734496	50734496	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr14:50734496C>T	ENST00000267436.4	-	8	1436	c.1039G>A	c.(1039-1041)Gat>Aat	p.D347N	L2HGDH_ENST00000261699.4_Missense_Mutation_p.D347N|L2HGDH_ENST00000421284.3_Missense_Mutation_p.D347N			Q9H9P8	L2HDH_HUMAN	L-2-hydroxyglutarate dehydrogenase	347					2-oxoglutarate metabolic process|cellular protein metabolic process	integral to mitochondrial inner membrane	2-hydroxyglutarate dehydrogenase activity			kidney(1)|large_intestine(4)|lung(3)|ovary(2)	10	all_epithelial(31;0.000599)|Breast(41;0.0102)					TCCATAACATCTGTGGCACTG	0.353000													5	48					0	0	1	0	0
PPIG	9360	broad.mit.edu	37	2	170460703	170460703	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:170460703G>A	ENST00000260970.3	+	4	288	c.68G>A	c.(67-69)aGa>aAa	p.R23K	PPIG_ENST00000448752.2_Missense_Mutation_p.R23K|PPIG_ENST00000409714.3_Missense_Mutation_p.R23K|PPIG_ENST00000462903.1_Missense_Mutation_p.R23K	NM_004792.2	NP_004783.2	Q13427	PPIG_HUMAN	peptidylprolyl isomerase G (cyclophilin G)	23	PPIase cyclophilin-type.				protein folding|RNA splicing	nuclear matrix|nuclear speck	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(17)|ovary(2)|stomach(1)|urinary_tract(1)	43					L-Proline(DB00172)	TCAGCTGGAAGAGTTGTCTTT	0.323000													6	108					0	0	1	0	0
TTLL6	284076	broad.mit.edu	37	17	46847447	46847447	+	Missense_Mutation	SNP	C	C	T	rs138167652	byFrequency	TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:46847447C>T	ENST00000393382.3	-	14	2194	c.2053G>A	c.(2053-2055)Gta>Ata	p.V685I	TTLL6_ENST00000433608.2_Missense_Mutation_p.V378I	NM_001130918.1	NP_001124390.1	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	637						cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			endometrium(1)|large_intestine(5)|lung(9)|prostate(1)|skin(2)	18						GTGGTTTCTACGGAGGTTAAG	0.463000													30	55					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227919411	227919411	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:227919411C>G	ENST00000396625.3	-	31	2966	c.2759G>C	c.(2758-2760)aGa>aCa	p.R920T	COL4A4_ENST00000329662.7_Missense_Mutation_p.R920T	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	920	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		AGGCTTTCCTCTTTCTCCGGG	0.507000													3	30					0	0	1	0	0
LRRC37A3	374819	broad.mit.edu	37	17	62856867	62856867	+	Missense_Mutation	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:62856867C>A	ENST00000584306.1	-	11	3927	c.3397G>T	c.(3397-3399)Gat>Tat	p.D1133Y	LRRC37A3_ENST00000334962.5_Missense_Mutation_p.D110Y|LRRC37A3_ENST00000339474.5_Missense_Mutation_p.D251Y|LRRC37A3_ENST00000400877.3_Missense_Mutation_p.D171Y|LRRC37A3_ENST00000319651.5_Missense_Mutation_p.D1133Y	NM_199340.2	NP_955372.2	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	1133						integral to membrane				NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|liver(1)|lung(10)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						GATTTCACATCTAGGTTAACG	0.438000													136	106					9.41252e-71	1.03716e-70	1	1	0
C7orf50	84310	broad.mit.edu	37	7	1049725	1049725	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:1049725C>T	ENST00000397098.3	-	3	1110	c.184G>A	c.(184-186)Gag>Aag	p.E62K	C7orf50_ENST00000397100.2_Missense_Mutation_p.E62K|C7orf50_ENST00000357429.6_Missense_Mutation_p.E62K|C7orf50_ENST00000488073.1_5'UTR			Q9BRJ6	CG050_HUMAN	chromosome 7 open reading frame 50	62							protein binding			kidney(1)|large_intestine(1)|lung(3)|ovary(1)	6		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0216)|OV - Ovarian serous cystadenocarcinoma(56;1.3e-15)		ACCCTCTGCTCCTCTGGGGAC	0.617000													8	23					0	0	1	0	0
ATP8B3	148229	broad.mit.edu	37	19	1796807	1796807	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:1796807G>A	ENST00000539485.1	-	16	1889	c.1656C>T	c.(1654-1656)ctC>ctT	p.L552L	ATP8B3_ENST00000310127.6_Silent_p.L552L|ATP8B3_ENST00000525591.1_Silent_p.L505L			O60423	AT8B3_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 3	552					ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	23		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGTCCGCACGAGGTGCAGCA	0.701000													18	28					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6161877	6161877	+	Missense_Mutation	SNP	G	G	C	rs61748462		TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:6161877G>C	ENST00000261405.5	-	16	2272	c.2018C>G	c.(2017-2019)tCt>tGt	p.S673C		NM_000552.3	NP_000543	P04275	VWF_HUMAN	von Willebrand factor	673	TIL 2.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	ATCCGGGTAAGAGAGAGAGCG	0.622000													41	24					0	0	1	0	0
ORAI2	80228	broad.mit.edu	37	7	102087136	102087136	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:102087136C>T	ENST00000356387.2	+	4	637	c.402C>T	c.(400-402)atC>atT	p.I134I	ORAI2_ENST00000403646.3_Silent_p.I134I|ORAI2_ENST00000478730.2_Silent_p.I134I|ORAI2_ENST00000488996.1_3'UTR|ORAI2_ENST00000473939.1_Silent_p.I134I	NM_001126340.1|NM_001271818.1|NM_001271819.1|NM_032831.3	NP_001119812.1|NP_001258747.1|NP_001258748.1|NP_116220.1	Q96SN7	ORAI2_HUMAN	ORAI calcium release-activated calcium modulator 2	134						integral to membrane	protein binding			autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(1)|lung(4)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	15						TGAACTCCATCAGCGAGTCCC	0.632000													93	91					0	0	1	0	0
INTU	27152	broad.mit.edu	37	4	128564709	128564709	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:128564709G>C	ENST00000335251.6	+	2	283	c.180G>C	c.(178-180)caG>caC	p.Q60H	INTU_ENST00000296461.5_Missense_Mutation_p.Q60H	NM_015693.3	NP_056508.2	Q9ULD6	PDZD6_HUMAN	inturned planar cell polarity protein											breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	43						ACAGTGTGCAGAAAAATGGAG	0.403000													152	175					0	0	1	0	0
KANK1	23189	broad.mit.edu	37	9	730244	730244	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr9:730244C>T	ENST00000382303.1	+	8	3544	c.2892C>T	c.(2890-2892)ctC>ctT	p.L964L	KANK1_ENST00000489369.1_3'UTR|KANK1_ENST00000382293.3_Silent_p.L806L|KANK1_ENST00000382297.2_Silent_p.L964L	NM_001256876.1	NP_001243805.1	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1	964					negative regulation of actin filament polymerization	cytoplasm				autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(9)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|stomach(4)|upper_aerodigestive_tract(1)	43		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		CCGCTGGCCTCTATGGTAACT	0.498000													5	35					0	0	1	0	0
OAS1	4938	broad.mit.edu	37	12	113355508	113355508	+	Silent	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:113355508G>C	ENST00000452357.2	+	5	1231	c.1041G>C	c.(1039-1041)gtG>gtC	p.V347V	OAS1_ENST00000551241.1_Intron|OAS1_ENST00000202917.5_Intron|OAS1_ENST00000445409.2_Intron|RP1-71H24.1_ENST00000552784.1_RNA	NM_002534.2	NP_002525.2	P00973	OAS1_HUMAN	2'-5'-oligoadenylate synthetase 1, 40/46kDa	0					interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|ovary(2)|skin(1)	16						TTCTGCTGGTGAGACCTCCTG	0.537000													8	162					0	0	1	0	0
STK31	56164	broad.mit.edu	37	7	23775422	23775422	+	Nonsense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:23775422C>G	ENST00000354639.3	+	7	1144	c.680C>G	c.(679-681)tCa>tGa	p.S227*	STK31_ENST00000433467.2_Nonsense_Mutation_p.S250*|STK31_ENST00000355870.3_Nonsense_Mutation_p.S250*|STK31_ENST00000428484.1_Nonsense_Mutation_p.S227*|STK31_ENST00000405627.3_3'UTR	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	250							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						TCAAACCAGTCAACCTTCAGC	0.423000													5	84					0	0	1	0	0
ARMC5	79798	broad.mit.edu	37	16	31476000	31476000	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr16:31476000G>A	ENST00000457010.2	+	4	2357	c.1656G>A	c.(1654-1656)ctG>ctA	p.L552L	ARMC5_ENST00000268314.4_Silent_p.L552L|ARMC5_ENST00000408912.3_Silent_p.L647L|ARMC5_ENST00000563544.1_Silent_p.L552L|ARMC5_ENST00000412665.2_Silent_p.L196L|ARMC5_ENST00000538189.1_Silent_p.L584L	NM_024742.2	NP_079018.1	Q96C12	ARMC5_HUMAN	armadillo repeat containing 5	552							binding			central_nervous_system(1)|endometrium(4)|large_intestine(3)|liver(2)|lung(12)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28						ACGGCCTGCTGACCTATGTGA	0.701000													4	45					0	0	1	0	0
TGFBRAP1	9392	broad.mit.edu	37	2	105885990	105885990	+	Silent	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:105885990G>C	ENST00000393359.2	-	11	2571	c.2145C>G	c.(2143-2145)ctC>ctG	p.L715L	TGFBRAP1_ENST00000258449.1_Silent_p.L715L			Q8WUH2	TGFA1_HUMAN	transforming growth factor, beta receptor associated protein 1	715					regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|membrane	SMAD binding|small GTPase regulator activity|transforming growth factor beta receptor binding			central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	31						GCGTGTGAAAGAGTTGCTGGC	0.657000													14	16					0	0	1	0	0
ACTG1P17	283693	broad.mit.edu	37	15	83395430	83395430	+	RNA	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr15:83395430C>G	ENST00000560958.1	-	0	856					NR_036446.1																						CAGAACCACTCATTGCTGATG	0.567000													6	2					0	0	1	0	0
BRD8	10902	broad.mit.edu	37	5	137499823	137499823	+	Splice_Site	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:137499823C>T	ENST00000254900.5	-	14	2197		c.e14-1		BRD8_ENST00000402931.1_Splice_Site|BRD8_ENST00000515014.1_Intron|BRD8_ENST00000411594.2_Splice_Site|BRD8_ENST00000455658.2_Splice_Site|BRD8_ENST00000230901.5_Splice_Site	NM_139199.1	NP_631938	Q9H0E9	BRD8_HUMAN	bromodomain containing 8						cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(3)|urinary_tract(1)	35			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			TTCAATGAGTCTGCAGAGGAG	0.418000													63	170					0	0	1	0	0
PLEKHG3	26030	broad.mit.edu	37	14	65199580	65199580	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr14:65199580G>A	ENST00000247226.7	+	10	1446	c.1138G>A	c.(1138-1140)Gag>Aag	p.E380K	PLEKHG3_ENST00000394691.1_Missense_Mutation_p.E436K	NM_015549.1	NP_056364.1	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	436	PH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(5)|kidney(2)|large_intestine(1)|lung(14)|prostate(2)|skin(3)|urinary_tract(2)	29				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		CTCCCAGGATGAGGTGTCCAC	0.607000													7	1					0	0	1	0	0
CARD11	84433	broad.mit.edu	37	7	2983870	2983870	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:2983870C>T	ENST00000396946.4	-	5	1063	c.660G>A	c.(658-660)atG>atA	p.M220I	AC004906.3_ENST00000423194.1_RNA	NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	220					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		CTCGGCTCCTCATGACCGCCA	0.572000			Mis		DLBCL								16	53					0	0	1	0	0
DESI1	27351	broad.mit.edu	37	22	41999386	41999386	+	Splice_Site	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr22:41999386C>G	ENST00000263256.6	-	5	547		c.e5-1		DESI1_ENST00000463886.1_Splice_Site	NM_015704.2	NP_056519.1	Q6ICB0	PPDE2_HUMAN	desumoylating isopeptidase 1																		GGCCTCACCTCTGTACATTGA	0.458000													45	77					0	0	1	0	0
SPRYD3	84926	broad.mit.edu	37	12	53468949	53468949	+	Nonsense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:53468949G>A	ENST00000301463.4	-	4	387	c.301C>T	c.(301-303)Cag>Tag	p.Q101*	SPRYD3_ENST00000547837.1_Nonsense_Mutation_p.Q138*	NM_032840.2	NP_116229.1	Q8NCJ5	SPRY3_HUMAN	SPRY domain containing 3	101	B30.2/SPRY.									central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	17						CTGTAGTACTGAGGGACCAGC	0.582000													77	44					0	0	1	0	0
IL27RA	9466	broad.mit.edu	37	19	14142711	14142711	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:14142711C>T	ENST00000263379.2	+	1	152	c.27C>T	c.(25-27)ttC>ttT	p.F9F		NM_004843.3	NP_004834.1	Q6UWB1	I27RA_HUMAN	interleukin 27 receptor, alpha	9					cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	26						GCGCCCCTTTCTGGCTGTGGC	0.726000													6	14					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9070618	9070618	+	Silent	SNP	G	G	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:9070618G>T	ENST00000397910.4	-	3	17031	c.16828C>A	c.(16828-16830)Cgg>Agg	p.R5610R		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5612	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.R5610W(2)|p.R1243W(1)		NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTTCTGCTCCGAAGAGTGGTT	0.527000													6	83					0.00116845	0.00117986	1	1	0
POLRMT	5442	broad.mit.edu	37	19	630136	630136	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:630136C>T	ENST00000588649.2	-	3	310	c.226G>A	c.(226-228)Gag>Aag	p.E76K		NM_005035.3	NP_005026.3	O00411	RPOM_HUMAN	polymerase (RNA) mitochondrial (DNA directed)	76					transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			cervix(2)|endometrium(3)|large_intestine(1)|lung(9)|ovary(1)|pancreas(2)|prostate(1)|stomach(1)	20		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GACACGCTCTCAGCCTGCAGC	0.652000													79	79					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187542068	187542068	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:187542068G>C	ENST00000441802.2	-	10	5881	c.5672C>G	c.(5671-5673)cCa>cGa	p.P1891R		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	1891	Cadherin 17.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						TTTGTATGTTGGTAACAAAAG	0.408000										HNSCC(5;0.00058)			4	58					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41552280	41552280	+	Nonsense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr8:41552280G>A	ENST00000396942.1	-	28	3240	c.3157C>T	c.(3157-3159)Cga>Tga	p.R1053*	ANK1_ENST00000265709.8_Nonsense_Mutation_p.R1094*|ANK1_ENST00000379758.2_Nonsense_Mutation_p.R1053*|ANK1_ENST00000352337.4_Nonsense_Mutation_p.R1053*|ANK1_ENST00000347528.4_Nonsense_Mutation_p.R1053*|ANK1_ENST00000289734.7_Nonsense_Mutation_p.R1053*|ANK1_ENST00000396945.1_Nonsense_Mutation_p.R1053*			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	1053					axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			GTGATGATTCGGCACACCCTC	0.592000													10	18					0	0	1	0	0
DAZAP1	26528	broad.mit.edu	37	19	1434778	1434778	+	Nonsense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:1434778C>G	ENST00000233078.4	+	12	1252	c.1091C>G	c.(1090-1092)tCa>tGa	p.S364*	DAZAP1_ENST00000336761.6_3'UTR	NM_018959.2	NP_061832.2	Q96EP5	DAZP1_HUMAN	DAZ associated protein 1	364	Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleotide binding|RNA binding			breast(2)|endometrium(2)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(1)	9		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGGGCTTCTCAGACCCCAGC	0.706000													44	32					0	0	1	0	0
SYTL3	94120	broad.mit.edu	37	6	159103970	159103970	+	Missense_Mutation	SNP	A	A	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:159103970A>G	ENST00000297239.9	+	5	537	c.343A>G	c.(343-345)Aaa>Gaa	p.K115E	SYTL3_ENST00000360448.3_Missense_Mutation_p.K115E|SYTL3_ENST00000367081.3_5'UTR			Q4VX76	SYTL3_HUMAN	synaptotagmin-like 3	115	RabBD.				intracellular protein transport	endomembrane system|membrane	Rab GTPase binding			endometrium(2)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|urinary_tract(1)	20		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.54e-17)|BRCA - Breast invasive adenocarcinoma(81;8.24e-06)		TGTCAAAATAAAAACTGGAGA	0.348000													12	20					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48559844	48559844	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:48559844C>G	ENST00000435803.1	+	53	14029	c.14005C>G	c.(14005-14007)Ctc>Gtc	p.L4669V	ABCA13_ENST00000544596.1_Missense_Mutation_p.L399V	NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	4669					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						CACAGTACTTCTCCTCTTGAG	0.532000													3	41					0	0	1	0	0
KCNH7	90134	broad.mit.edu	37	2	163302588	163302588	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:163302588C>T	ENST00000332142.5	-	7	1593	c.1494G>A	c.(1492-1494)ctG>ctA	p.L498L	KCNH7_ENST00000328032.4_Silent_p.L491L	NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	498					regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	CCATGTCAATCAGGAACCAGC	0.353000													25	18					0	0	1	0	0
GTF2IRD1	9569	broad.mit.edu	37	7	74004241	74004241	+	Silent	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:74004241C>G	ENST00000476977.1	+	23	4073	c.2382C>G	c.(2380-2382)ctC>ctG	p.L794L	GTF2IRD1_ENST00000424337.2_Silent_p.L794L|GTF2IRD1_ENST00000455841.2_Silent_p.L826L|GTF2IRD1_ENST00000265755.3_Silent_p.L809L			Q9UHL9	GT2D1_HUMAN	GTF2I repeat domain containing 1	809						nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			NS(1)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(19)|ovary(6)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						TGAAGGAACTCTTCAACGAGA	0.597000													12	17					0	0	1	0	0
SREBF1	6720	broad.mit.edu	37	17	17721227	17721227	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:17721227G>A	ENST00000355815.4	-	8	1446	c.1277C>T	c.(1276-1278)tCt>tTt	p.S426F	SREBF1_ENST00000261646.5_Missense_Mutation_p.S396F|SREBF1_ENST00000338854.5_Missense_Mutation_p.S396F|SREBF1_ENST00000435530.2_Missense_Mutation_p.S396F|SREBF1_ENST00000395757.1_Missense_Mutation_p.S142F	NM_001005291.2	NP_001005291.1	P36956	SRBP1_HUMAN	sterol regulatory element binding transcription factor 1	396	Interaction with LMNA (By similarity).				cellular response to starvation|cholesterol metabolic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleus	protein binding|sequence-specific DNA binding transcription factor activity|sterol response element binding			cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|urinary_tract(1)	14						ATCCTTCAGAGATTCTGTGGG	0.587000													52	3					0	0	1	0	0
HKR1	284459	broad.mit.edu	37	19	37854460	37854460	+	Missense_Mutation	SNP	T	T	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:37854460T>C	ENST00000591471.1	+	9	2585	c.944T>C	c.(943-945)tTt>tCt	p.F315S	HKR1_ENST00000541583.2_Missense_Mutation_p.F527S|HKR1_ENST00000544914.1_Missense_Mutation_p.F315S|HKR1_ENST00000589392.1_Missense_Mutation_p.F570S|HKR1_ENST00000591134.1_Intron|HKR1_ENST00000324411.4_Missense_Mutation_p.F588S|HKR1_ENST00000392153.3_Missense_Mutation_p.F569S			P10072	HKR1_HUMAN	HKR1, GLI-Kruppel zinc finger family member	588					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	29			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GGGCAAGGCTTTTGTGCTAAG	0.552000													53	50					0	0	1	0	0
BRD8	10902	broad.mit.edu	37	5	137499815	137499815	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:137499815C>T	ENST00000254900.5	-	14	2204	c.1833G>A	c.(1831-1833)ttG>ttA	p.L611L	BRD8_ENST00000402931.1_Silent_p.L611L|BRD8_ENST00000515014.1_Intron|BRD8_ENST00000411594.2_Silent_p.L614L|BRD8_ENST00000455658.2_Silent_p.L570L|BRD8_ENST00000230901.5_Silent_p.L684L	NM_139199.1	NP_631938	Q9H0E9	BRD8_HUMAN	bromodomain containing 8	611					cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(3)|urinary_tract(1)	35			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			ATTCTTCTTTCAATGAGTCTG	0.413000													69	185					0	0	1	0	0
FMO1	2326	broad.mit.edu	37	1	171244580	171244580	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:171244580C>T	ENST00000354841.4	+	3	548	c.417C>T	c.(415-417)atC>atT	p.I139I	FMO1_ENST00000469112.1_3'UTR|FMO1_ENST00000367750.3_Silent_p.I139I|FMO1_ENST00000402921.2_Silent_p.I76I	NM_001282692.1	NP_001269621.1	Q01740	FMO1_HUMAN	flavin containing monooxygenase 1	139					NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum lumen|integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(2)|skin(2)	27	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					AGTCAGCCATCTTTGATGCTG	0.428000													29	103					0	0	1	0	0
RALGAPA1	253959	broad.mit.edu	37	14	36244214	36244214	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr14:36244214C>G	ENST00000258840.6	-	3	655	c.265G>C	c.(265-267)Gag>Cag	p.E89Q	RALGAPA1_ENST00000307138.6_Missense_Mutation_p.E89Q|RALGAPA1_ENST00000382366.3_Missense_Mutation_p.E89Q|RALGAPA1_ENST00000389698.3_Missense_Mutation_p.E89Q	NM_001283044.1	NP_001269973.1	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1 (catalytic)	89					activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(7)|large_intestine(14)|lung(21)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						GCACTTACCTCAAAAATAAAA	0.259000													13	3					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	82147793	82147793	+	Nonsense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:82147793G>A	ENST00000550584.2	-	2	503	c.208C>T	c.(208-210)Cga>Tga	p.R70*	PPFIA2_ENST00000548586.1_Nonsense_Mutation_p.R70*|PPFIA2_ENST00000549396.1_Nonsense_Mutation_p.R70*|PPFIA2_ENST00000552948.1_Nonsense_Mutation_p.R70*|PPFIA2_ENST00000333447.7_Nonsense_Mutation_p.R70*|PPFIA2_ENST00000549325.1_Nonsense_Mutation_p.R70*	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	329										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						AGTGAGTCTCGGTCATAGATG	0.468000													11	21					0	0	1	0	0
EIF5AL1	143244	broad.mit.edu	37	10	81272751	81272751	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr10:81272751G>A	ENST00000520547.2	+	1	395	c.346G>A	c.(346-348)Gag>Aag	p.E116K		NM_001099692.1	NP_001093162.1	Q6IS14	IF5AL_HUMAN	eukaryotic translation initiation factor 5A-like 1	116					mRNA transport|peptidyl-lysine modification to hypusine|positive regulation of translational elongation|positive regulation of translational termination|protein transport|translational frameshifting|transmembrane transport	endoplasmic reticulum membrane|nuclear pore	ribosome binding|translation elongation factor activity			endometrium(1)	1	all_cancers(46;0.197)|Breast(12;0.000326)|Prostate(51;0.00985)|all_epithelial(25;0.0149)		Epithelial(14;0.00957)|all cancers(16;0.0179)|Colorectal(32;0.229)			TCGTCTCCCTGAGGGAGACCT	0.537000													48	161					0	0	1	0	0
POM121L12	285877	broad.mit.edu	37	7	53103781	53103781	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:53103781C>T	ENST00000408890.4	+	1	433	c.417C>T	c.(415-417)atC>atT	p.I139I		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	139								p.I139M(1)|p.I139I(1)		endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						CGGTGACCATCGGGATCGCGC	0.716000													16	55					0	0	1	0	0
ADCK3	56997	broad.mit.edu	37	1	227149231	227149231	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:227149231G>C	ENST00000366779.1	+	7	2916	c.145G>C	c.(145-147)Gag>Cag	p.E49Q	ADCK3_ENST00000366778.1_5'UTR|ADCK3_ENST00000366777.3_Missense_Mutation_p.E49Q|ADCK3_ENST00000478406.1_Intron|ADCK3_ENST00000458507.2_Intron			Q8NI60	ADCK3_HUMAN	aarF domain containing kinase 3	49					cell death	mitochondrion	ATP binding|protein serine/threonine kinase activity			endometrium(1)|kidney(2)|large_intestine(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	9						CACGGCTGTGGAGCAGATTGG	0.657000													30	31					0	0	1	0	0
LIG3	3980	broad.mit.edu	37	17	33321330	33321330	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:33321330G>A	ENST00000378526.4	+	9	1624	c.1491G>A	c.(1489-1491)aaG>aaA	p.K497K	LIG3_ENST00000262327.5_Silent_p.K497K	NM_013975.3	NP_039269.2	P49916	DNLI3_HUMAN	ligase III, DNA, ATP-dependent	497					base-excision repair|cell division|DNA ligation involved in DNA repair|DNA replication|reciprocal meiotic recombination|spermatogenesis	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|protein binding|zinc ion binding			endometrium(4)|large_intestine(8)|lung(9)|ovary(3)|pancreas(2)|prostate(1)|skin(3)|stomach(1)	31		Ovarian(249;0.17)			Bleomycin(DB00290)	ATGCAATGAAGAAATGTCCCA	0.527000								Other BER factors					37	60					0	0	1	0	0
MON1B	22879	broad.mit.edu	37	16	77232007	77232007	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr16:77232007G>A	ENST00000248248.3	+	6	1796	c.1446G>A	c.(1444-1446)gtG>gtA	p.V482V	MON1B_ENST00000439557.2_Silent_p.V373V|MON1B_ENST00000545553.1_Silent_p.V336V	NM_014940.2	NP_055755.1	Q7L1V2	MON1B_HUMAN	MON1 secretory trafficking family member B	482							protein binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	17						ACCCCCAGGTGACCTCCAAAT	0.572000													6	302					0	0	1	0	0
ZBTB21	49854	broad.mit.edu	37	21	43413854	43413854	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr21:43413854G>A	ENST00000310826.5	-	3	534	c.351C>T	c.(349-351)atC>atT	p.I117I	ZBTB21_ENST00000465968.1_Intron|ZBTB21_ENST00000398499.1_Silent_p.I117I|ZBTB21_ENST00000398505.3_Silent_p.I117I|ZBTB21_ENST00000398511.3_Silent_p.I117I	NM_001098402.1	NP_001091872.1			zinc finger and BTB domain containing 21																		TTTTAGAAACGATGTTAGTCA	0.383000													29	23					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74015620	74015620	+	Nonsense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:74015620G>A	ENST00000301607.3	-	10	1379	c.1126C>T	c.(1126-1128)Caa>Taa	p.Q376*	EVPL_ENST00000586740.1_Nonsense_Mutation_p.Q376*	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	376	Globular 1.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						TCCAGCTGTTGCAGCAGCTCT	0.622000													13	23					0	0	1	0	0
TRIM11	81559	broad.mit.edu	37	1	228588850	228588850	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:228588850G>A	ENST00000493030.2	-	2	3884	c.175C>T	c.(175-177)Cgt>Tgt	p.R59C	TRIM11_ENST00000366699.3_Missense_Mutation_p.R184C|TRIM11_ENST00000460651.1_5'UTR|TRIM11_ENST00000284551.6_Missense_Mutation_p.R184C			Q96F44	TRI11_HUMAN	tripartite motif containing 11	184					response to virus	cytoplasm|nucleus	protein binding|zinc ion binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|skin(1)	18		Prostate(94;0.0724)				CGGCGAAGACGCTCGAACTCA	0.677000													17	52					0	0	1	0	0
SLC10A7	84068	broad.mit.edu	37	4	147215121	147215121	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:147215121C>G	ENST00000432059.2	-	7	889	c.643G>C	c.(643-645)Gac>Cac	p.D215H	SLC10A7_ENST00000394062.3_Missense_Mutation_p.D228H|SLC10A7_ENST00000264986.3_3'UTR|SLC10A7_ENST00000507030.1_Missense_Mutation_p.D228H|SLC10A7_ENST00000335472.7_Missense_Mutation_p.D228H			Q0GE19	NTCP7_HUMAN	solute carrier family 10, member 7	228						integral to membrane	bile acid:sodium symporter activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(8)|skin(1)	16	all_hematologic(180;0.151)					TTATCCAGGTCAATATTTGGG	0.438000													6	127					0	0	1	0	0
KLC4	89953	broad.mit.edu	37	6	43042397	43042397	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:43042397C>G	ENST00000394056.2	+	17	2342	c.1847C>G	c.(1846-1848)tCt>tGt	p.S616C	RP11-387M24.5_ENST00000606123.1_RNA|KLC4_ENST00000479388.1_Missense_Mutation_p.S616C|KLC4_ENST00000259708.3_Missense_Mutation_p.S634C|KLC4_ENST00000347162.5_Missense_Mutation_p.S616C|KLC4_ENST00000394058.1_Missense_Mutation_p.S616C|KLC4_ENST00000453940.2_Missense_Mutation_p.S539C			Q9NSK0	KLC4_HUMAN	kinesin light chain 4	616						cytoplasm|kinesin complex|microtubule	microtubule motor activity|protein binding			endometrium(2)|large_intestine(7)|lung(5)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(4)	23			all cancers(41;0.00169)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0376)|KIRC - Kidney renal clear cell carcinoma(2;0.0453)			ATGGACCTCTCTTCAAGCAGC	0.632000													7	37					0	0	1	0	0
KARS	3735	broad.mit.edu	37	16	75663316	75663316	+	Silent	SNP	G	G	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr16:75663316G>T	ENST00000319410.5	-	13	1753	c.1632C>A	c.(1630-1632)gcC>gcA	p.A544A	KARS_ENST00000568378.1_Intron|KARS_ENST00000302445.3_Silent_p.A516A	NM_001130089.1	NP_001123561.1	Q15046	SYK_HUMAN	lysyl-tRNA synthetase	516					interspecies interaction between organisms|lysyl-tRNA aminoacylation|tRNA processing	cytosol|extracellular region|mitochondrial matrix|nucleus|plasma membrane|soluble fraction	ATP binding|lysine-tRNA ligase activity|metal ion binding|tRNA binding			kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	18					L-Lysine(DB00123)	TTCTCACCTTGGCCTGTTCTT	0.493000													35	115					6.05902e-23	6.54458e-23	1	1	0
PLEKHS1	79949	broad.mit.edu	37	10	115535606	115535606	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr10:115535606G>A	ENST00000354462.3	+	4	420	c.262G>A	c.(262-264)Gaa>Aaa	p.E88K	PLEKHS1_ENST00000369309.1_Missense_Mutation_p.E172K|PLEKHS1_ENST00000369310.3_Missense_Mutation_p.E338K|PLEKHS1_ENST00000361048.1_Missense_Mutation_p.E358K|PLEKHS1_ENST00000369312.4_Missense_Mutation_p.E256K					pleckstrin homology domain containing, family S member 1																		TGCTCTCACAGAAGCCACAGG	0.413000													6	133					0	0	1	0	0
ATP8A1	10396	broad.mit.edu	37	4	42558015	42558015	+	Silent	SNP	T	T	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:42558015T>C	ENST00000381668.5	-	16	1614	c.1383A>G	c.(1381-1383)tcA>tcG	p.S461S	ATP8A1_ENST00000264449.10_Silent_p.S446S	NM_006095.2	NP_006086.1	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	461					ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	51					Phosphatidylserine(DB00144)	CCAGCAATGATGAATCACTAA	0.323000													4	37					0	0	1	0	0
ABHD16A	7920	broad.mit.edu	37	6	31656525	31656525	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:31656525G>A	ENST00000375842.4	-	14	1554	c.568C>T	c.(568-570)Cta>Tta	p.L190L	ABHD16A_ENST00000395952.3_Silent_p.L409L|XXbac-BPG32J3.20_ENST00000461287.1_3'UTR|ABHD16A_ENST00000440843.2_Silent_p.L376L|ABHD16A_ENST00000471644.1_5'UTR			O95870	ABHGA_HUMAN	abhydrolase domain containing 16A	409						integral to membrane	hydrolase activity|protein binding			endometrium(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)	10						GCGTTGTTTAGATTGAGATGC	0.587000													29	14					0	0	1	0	0
PDXDC2P	283970	broad.mit.edu	37	16	70068170	70068170	+	RNA	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr16:70068170G>A	ENST00000531894.1	-	0	654					NR_003610.1																						CATCCACTACGAAGTCTTCAT	0.413000													9	80					0	0	1	0	0
LGSN	51557	broad.mit.edu	37	6	63990078	63990078	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:63990078C>G	ENST00000370657.4	-	4	1411	c.1378G>C	c.(1378-1380)Gaa>Caa	p.E460Q	LGSN_ENST00000370658.5_3'UTR			Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase domain	460					glutamine biosynthetic process		glutamate-ammonia ligase activity			NS(1)|endometrium(2)|large_intestine(5)|lung(16)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	34					L-Glutamic Acid(DB00142)	AGGGCATCTTCTAGTTTTAAA	0.438000													47	21					0	0	1	0	0
LAIR1	3903	broad.mit.edu	37	19	54867579	54867579	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:54867579C>T	ENST00000391743.3	-	8	927	c.647G>A	c.(646-648)aGa>aAa	p.R216K	LAIR1_ENST00000434277.2_Missense_Mutation_p.R233K|LAIR1_ENST00000391742.2_Missense_Mutation_p.R234K|LAIR1_ENST00000313038.6_Missense_Mutation_p.R227K|LAIR1_ENST00000474878.1_Missense_Mutation_p.R216K|LAIR1_ENST00000348231.4_Missense_Mutation_p.R217K			Q6GTX8	LAIR1_HUMAN	leukocyte-associated immunoglobulin-like receptor 1	234						integral to membrane|plasma membrane	protein binding|receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(9)|ovary(4)|prostate(1)|stomach(3)	26	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0573)		GTCCGTCTCTCTGTCCTTCTC	0.463000													27	54					0	0	1	0	0
CCDC146	57639	broad.mit.edu	37	7	76797043	76797043	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:76797043G>A	ENST00000285871.4	+	2	185	c.58G>A	c.(58-60)Gat>Aat	p.D20N	CCDC146_ENST00000431197.1_5'UTR|RP11-467H10.2_ENST00000459742.1_RNA	NM_020879.2	NP_065930.2	Q8IYE0	CC146_HUMAN	coiled-coil domain containing 146	20										breast(3)|central_nervous_system(3)|endometrium(1)|kidney(4)|large_intestine(7)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(2)	34		all_cancers(73;0.128)|all_lung(88;0.0986)|all_epithelial(88;0.163)|Myeloproliferative disorder(862;0.205)				AGATGAAAAGGATCAAGAGCC	0.358000													12	34					0	0	1	0	0
DNAJB12	54788	broad.mit.edu	37	10	74098043	74098043	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr10:74098043C>T	ENST00000338820.3	-	6	1001	c.852G>A	c.(850-852)ctG>ctA	p.L284L	DNAJB12_ENST00000461919.1_Silent_p.L45L|DNAJB12_ENST00000444643.2_Silent_p.L250L|DNAJB12_ENST00000394903.2_Silent_p.L284L	NM_001002762.2	NP_001002762.2	Q9NXW2	DJB12_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 12	250					protein folding	endoplasmic reticulum|integral to membrane	heat shock protein binding|unfolded protein binding			endometrium(1)|large_intestine(2)|skin(1)	4						GGATAGGCATCAGCTGCACAA	0.572000													34	38					0	0	1	0	0
DOCK3	1795	broad.mit.edu	37	3	51101878	51101878	+	Splice_Site	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:51101878G>A	ENST00000266037.9	+	6	338		c.e6-1			NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3							cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		TGCCCTTTCAGAAACACAAAG	0.388000													9	170					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33468840	33468840	+	Nonsense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:33468840C>G	ENST00000404816.2	+	10	2341	c.1988C>G	c.(1987-1989)tCa>tGa	p.S663*	LTBP1_ENST00000418533.2_Nonsense_Mutation_p.S337*|LTBP1_ENST00000390003.4_Nonsense_Mutation_p.S337*|LTBP1_ENST00000404525.1_Nonsense_Mutation_p.S337*|LTBP1_ENST00000407925.1_Nonsense_Mutation_p.S337*|LTBP1_ENST00000402934.1_Nonsense_Mutation_p.S337*|LTBP1_ENST00000354476.3_Nonsense_Mutation_p.S663*			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	663	EGF-like 3; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				CCTACCTTTTCAAGTTGTGTT	0.403000													32	31					0	0	1	0	0
DCLK2	166614	broad.mit.edu	37	4	151170830	151170830	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:151170830C>T	ENST00000296550.7	+	15	2821	c.2067C>T	c.(2065-2067)gtC>gtT	p.V689V	DCLK2_ENST00000506325.1_Silent_p.V688V|DCLK2_ENST00000302176.8_Silent_p.V706V	NM_001040260.3	NP_001035350.2	Q8N568	DCLK2_HUMAN	doublecortin-like kinase 2	689					intracellular signal transduction	cytoplasm|cytoskeleton	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(7)|ovary(3)|pancreas(1)|prostate(1)|skin(1)	26	all_hematologic(180;0.151)					GGGTCTCCGTCATCATGGTGA	0.532000													8	147					0	0	1	0	0
DSCAML1	57453	broad.mit.edu	37	11	117335849	117335849	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:117335849C>T	ENST00000321322.6	-	17	3255	c.3254G>A	c.(3253-3255)gGc>gAc	p.G1085D	DSCAML1_ENST00000527706.1_Missense_Mutation_p.G815D	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1025	Fibronectin type-III 2.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CTCTCTGTAGCCAATCTGGTA	0.592000													51	18					0	0	1	0	0
GOPC	57120	broad.mit.edu	37	6	117884440	117884440	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:117884440G>A	ENST00000535237.1	-	9	1595	c.1366C>T	c.(1366-1368)Ctg>Ttg	p.L456L	GOPC_ENST00000368498.2_Silent_p.L456L|DCBLD1_ENST00000296955.8_Intron|GOPC_ENST00000052569.6_Silent_p.L448L|GOPC_ENST00000467125.1_Intron					golgi-associated PDZ and coiled-coil motif containing										GOPC/ROS1(14)	endometrium(1)|large_intestine(3)|lung(4)|ovary(1)	9		all_cancers(87;0.00844)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0363)|OV - Ovarian serous cystadenocarcinoma(136;0.0821)|all cancers(137;0.0976)		TTATGATACAGAGTGTGCAGA	0.403000			O	ROS1	glioblastoma								24	52					0	0	1	0	0
LAMC3	10319	broad.mit.edu	37	9	133945108	133945108	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr9:133945108C>T	ENST00000361069.4	+	17	3073	c.2940C>T	c.(2938-2940)aaC>aaT	p.N980N	LAMC3_ENST00000480883.1_Intron	NM_006059.3	NP_006050.3	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3	980	Laminin EGF-like 11.				cell adhesion	basement membrane|membrane	structural molecule activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(31)|ovary(3)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	69	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		GCCACGAGAACGGCACATGCG	0.652000													9	0					0	0	1	0	0
DDX41	51428	broad.mit.edu	37	5	176940701	176940701	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:176940701G>C	ENST00000507955.1	-	10	1606	c.1083C>G	c.(1081-1083)atC>atG	p.I361M		NM_016222.2	NP_057306.2	Q9UJV9	DDX41_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 41	361	Helicase ATP-binding.				apoptosis|multicellular organismal development	catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|zinc ion binding					all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.191)			AGTAGGAGAAGATGGTACGGA	0.642000													51	43					0	0	1	0	0
MAGED1	9500	broad.mit.edu	37	X	51638299	51638299	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chrX:51638299C>G	ENST00000375695.2	+	4	517	c.364C>G	c.(364-366)Cag>Gag	p.Q122E	MAGED1_ENST00000326587.7_Missense_Mutation_p.Q66E|MAGED1_ENST00000494718.1_3'UTR|MAGED1_ENST00000375722.1_Missense_Mutation_p.Q66E|MAGED1_ENST00000375772.3_Missense_Mutation_p.Q66E	NM_001005333.1	NP_001005333.1	Q9Y5V3	MAGD1_HUMAN	melanoma antigen family D, 1	66					apoptosis|induction of apoptosis by extracellular signals|negative regulation of epithelial cell proliferation|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent	cytoplasm|plasma membrane|protein complex	protein binding			breast(1)|endometrium(4)|large_intestine(10)|lung(13)|ovary(3)|upper_aerodigestive_tract(1)	32	Ovarian(276;0.236)					GGCTGACATTCAGGTTTCAGC	0.532000										Multiple Myeloma(10;0.10)			17	1					0	0	1	0	0
BPIFB6	128859	broad.mit.edu	37	20	31619496	31619496	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr20:31619496G>A	ENST00000349552.1	+	1	43	c.43G>A	c.(43-45)Ggc>Agc	p.G15S		NM_174897.2	NP_777557.1	Q8NFQ5	BPIL3_HUMAN	BPI fold containing family B, member 6	15						extracellular region	lipid binding										CCTGCTGACTGGCACGCGAGC	0.672000													7	57					0	0	1	0	0
ETV4	2118	broad.mit.edu	37	17	41610246	41610246	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:41610246C>T	ENST00000319349.5	-	8	905	c.607G>A	c.(607-609)Gaa>Aaa	p.E203K	ETV4_ENST00000591713.1_Missense_Mutation_p.E203K|ETV4_ENST00000545089.1_Missense_Mutation_p.E149K|ETV4_ENST00000538265.1_Missense_Mutation_p.E164K|ETV4_ENST00000545954.1_Missense_Mutation_p.E164K|ETV4_ENST00000393664.2_Missense_Mutation_p.E203K	NM_001079675.2	NP_001073143.1	P43268	ETV4_HUMAN	ets variant 4	203	Gln-rich.				positive regulation of transcription, DNA-dependent	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/ETV4(6)|CANT1/ETV4(3)|TMPRSS2/ETV4(13)|DDX5_ENST00000540698/ETV4(2)|KLK2/ETV4(2)	ovary(2)|upper_aerodigestive_tract(1)	3		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.0798)		GGGAGGGGTTCCCGGCCCCCT	0.572000			T	"""EWSR1, TMPRSS2, DDX5, KLK2, CANT1"""	"""Ewing sarcoma, Prostate carcinoma"""								38	75					0	0	1	0	0
FAM217A	222826	broad.mit.edu	37	6	4069641	4069641	+	Nonsense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:4069641C>T	ENST00000274673.3	-	7	1219	c.816G>A	c.(814-816)tgG>tgA	p.W272*	FAM217A_ENST00000380188.2_5'UTR	NM_173563.2	NP_775834.2	Q8IXS0	CF146_HUMAN	family with sequence similarity 217, member A	272																	CTGTCACTTTCCAATTGTCAG	0.423000													32	21					0	0	1	0	0
OR2D3	120775	broad.mit.edu	37	11	6942835	6942835	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:6942835G>A	ENST00000317834.3	+	1	631	c.603G>A	c.(601-603)ctG>ctA	p.L201L		NM_001004684.1	NP_001004684.1	Q8NGH3	OR2D3_HUMAN	olfactory receptor, family 2, subfamily D, member 3	201					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|large_intestine(7)|lung(12)|prostate(3)|skin(1)|stomach(1)	27		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CTGCCCTCCTGAAGCTGGCTT	0.463000													30	6					0	0	1	0	0
DAZAP1	26528	broad.mit.edu	37	19	1421149	1421149	+	Missense_Mutation	SNP	G	G	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:1421149G>T	ENST00000336761.6	+	5	511	c.306G>T	c.(304-306)caG>caT	p.Q102H	DAZAP1_ENST00000233078.4_Missense_Mutation_p.Q102H|DAZAP1_ENST00000586579.1_Splice_Site	NM_170711.1	NP_733829.1	Q96EP5	DAZP1_HUMAN	DAZ associated protein 1	102					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleotide binding|RNA binding			breast(2)|endometrium(2)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(1)	9		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTCAACAGCAGAAAGGACCCA	0.478000													4	143					0.00909568	0.00913497	1	1	0
ARFGAP2	84364	broad.mit.edu	37	11	47196568	47196568	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:47196568G>C	ENST00000524782.1	-	5	706	c.478C>G	c.(478-480)Caa>Gaa	p.Q160E	ARFGAP2_ENST00000426335.2_Intron|ARFGAP2_ENST00000395449.3_5'UTR|ARFGAP2_ENST00000419701.2_Intron|ARFGAP2_ENST00000319543.6_Intron	NM_001242832.1|NM_032389.4	NP_001229761.1|NP_115765.2	Q8N6H7	ARFG2_HUMAN	ADP-ribosylation factor GTPase activating protein 2	160	Required for interaction with coatomer.				protein transport|regulation of ARF GTPase activity|vesicle-mediated transport	Golgi membrane|nucleolus|plasma membrane	ARF GTPase activator activity|zinc ion binding			breast(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23						GCACTCACTTGAGTGTGTTCT	0.463000													14	415					0	0	1	0	0
GPR133	283383	broad.mit.edu	37	12	131593338	131593338	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:131593338G>C	ENST00000261654.5	+	18	2516	c.1957G>C	c.(1957-1959)Gag>Cag	p.E653Q	GPR133_ENST00000535015.1_Missense_Mutation_p.E685Q|GPR133_ENST00000543617.1_Missense_Mutation_p.E172Q|GPR133_ENST00000376682.4_Missense_Mutation_p.E339Q	NM_198827.3	NP_942122.2	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133	653					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(2)|endometrium(6)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|pancreas(6)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	67	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		GATGCTGGTGGAGGGGCTGCA	0.567000													12	215					0	0	1	0	0
MAPKAPK3	7867	broad.mit.edu	37	3	50655200	50655200	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:50655200G>C	ENST00000446044.1	+	4	800	c.204G>C	c.(202-204)caG>caC	p.Q68H	MAPKAPK3_ENST00000357955.2_Missense_Mutation_p.Q68H	NM_001243926.1	NP_001230855.1	Q16644	MAPK3_HUMAN	mitogen-activated protein kinase-activated protein kinase 3	68	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity			central_nervous_system(1)|ovary(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.0188)|Kidney(197;0.0223)		GCACTGGACAGAAGTGTGCCC	0.602000													55	60					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49698174	49698174	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:49698174G>C	ENST00000296452.4	+	6	9010	c.8896G>C	c.(8896-8898)Gat>Cat	p.D2966H		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	2966					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GGCAGAGCTGGATGAGGAGGA	0.592000													12	11					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79372964	79372964	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:79372964G>A	ENST00000264895.6	+	46	6942	c.6502G>A	c.(6502-6504)Ggg>Agg	p.G2168R		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2167					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						AGAACCTGGAGGGAGCTTTGC	0.368000													18	25					0	0	1	0	0
DIP2C	22982	broad.mit.edu	37	10	395353	395353	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr10:395353C>G	ENST00000280886.6	-	25	3114	c.3027G>C	c.(3025-3027)aaG>aaC	p.K1009N		NM_014974.2	NP_055789.1	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C (Drosophila)	1009						nucleus	catalytic activity|transcription factor binding			breast(8)|endometrium(6)|kidney(10)|large_intestine(13)|lung(26)|ovary(3)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	81		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		TCTCAGCTCTCTTGTGCAGCT	0.617000													29	39					0	0	1	0	0
CEP57	9702	broad.mit.edu	37	11	95546175	95546175	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:95546175G>A	ENST00000325542.5	+	3	520	c.282G>A	c.(280-282)gtG>gtA	p.V94V	CEP57_ENST00000538658.1_Silent_p.V94V|CEP57_ENST00000541150.1_Silent_p.V85V|CEP57_ENST00000325486.5_Silent_p.V94V|CEP57_ENST00000536587.1_3'UTR|CEP57_ENST00000537677.1_Silent_p.V67V	NM_001243776.1|NM_014679.4	NP_001230705.1|NP_055494.2	Q86XR8	CEP57_HUMAN	centrosomal protein 57kDa	94	centrosome localization domain (CLD) (By similarity).				fibroblast growth factor receptor signaling pathway|G2/M transition of mitotic cell cycle|protein import into nucleus, translocation|spermatid development	centrosome|cytosol|Golgi apparatus|microtubule|nucleus	fibroblast growth factor binding|protein homodimerization activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	13		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				AAGAAAGTGTGAAAACCTTGT	0.363000									Mosaic Variegated Aneuploidy Syndrome				4	55					0	0	1	0	0
WDR46	9277	broad.mit.edu	37	6	33256694	33256694	+	Missense_Mutation	SNP	G	G	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:33256694G>T	ENST00000374617.4	-	2	522	c.166C>A	c.(166-168)Cag>Aag	p.Q56K	WDR46_ENST00000477718.1_5'UTR	NM_001164267.1|NM_005452.5	NP_001157739.1|NP_005443.3	O15213	WDR46_HUMAN	WD repeat domain 46	56										NS(1)|breast(2)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)	20						TTTGGTCTCTGAGGACGGAGC	0.552000													16	57					1.3612e-06	1.40971e-06	1	1	0
RSC1A1	6248	broad.mit.edu	37	1	15986751	15986751	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:15986751G>A	ENST00000345034.1	+	1	388	c.388G>A	c.(388-390)Gaa>Aaa	p.E130K	DDI2_ENST00000480945.1_3'UTR	NM_006511.1	NP_006502.1	Q92681	RSCA1_HUMAN	regulatory solute carrier protein, family 1, member 1	130					negative regulation of transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transport	cell junction|Golgi apparatus|nucleus	ion channel inhibitor activity			kidney(1)|large_intestine(3)|lung(6)|ovary(1)	11		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00276)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.73e-07)|COAD - Colon adenocarcinoma(227;3.49e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000114)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TACAAGACAGGAAGCTAGTTT	0.418000													63	117					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179659276	179659276	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:179659276C>T	ENST00000589042.1	-	8	1472	c.1248G>A	c.(1246-1248)gtG>gtA	p.V416V	TTN_ENST00000342992.6_Silent_p.V416V|TTN_ENST00000359218.5_Silent_p.V416V|TTN_ENST00000342175.6_Silent_p.V416V|TTN_ENST00000591111.1_Silent_p.V416V|TTN_ENST00000460472.2_Silent_p.V416V|TTN_ENST00000360870.5_Silent_p.V416V	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	416	Ala-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATCTTGTTTCACCTAGATTA	0.418000													7	85					0	0	1	0	0
FBXO22	26263	broad.mit.edu	37	15	76225119	76225119	+	Silent	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr15:76225119C>G	ENST00000308275.3	+	7	993	c.888C>G	c.(886-888)gtC>gtG	p.V296V	FBXO22_ENST00000540507.1_Silent_p.V192V	NM_147188.2	NP_671717.1	Q8NEZ5	FBX22_HUMAN	F-box protein 22	296					ubiquitin-dependent protein catabolic process		ubiquitin-protein ligase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	21						ACGAGGACGTCAGTGATGAGA	0.537000													31	42					0	0	1	0	0
BAZ1A	11177	broad.mit.edu	37	14	35230989	35230989	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr14:35230989C>G	ENST00000360310.1	-	24	4784	c.4217G>C	c.(4216-4218)aGa>aCa	p.R1406T	BAZ1A_ENST00000358716.4_Missense_Mutation_p.R1374T|BAZ1A_ENST00000382422.2_Missense_Mutation_p.R1406T	NM_013448.2	NP_038476.2	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	1406					chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(2)|large_intestine(7)|lung(19)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		TCTGCATCTTCTTTTGGATTC	0.348000													10	62					0	0	1	0	0
TPD52L1	7164	broad.mit.edu	37	6	125550309	125550309	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:125550309G>C	ENST00000534000.1	+	3	477	c.181G>C	c.(181-183)Gaa>Caa	p.E61Q	TPD52L1_ENST00000534199.1_Missense_Mutation_p.E32Q|TPD52L1_ENST00000368388.2_Missense_Mutation_p.E61Q|TPD52L1_ENST00000368402.5_Missense_Mutation_p.E61Q|TPD52L1_ENST00000392482.2_Missense_Mutation_p.E32Q|TPD52L1_ENST00000527711.1_Missense_Mutation_p.E61Q|TPD52L1_ENST00000304877.13_Missense_Mutation_p.E61Q|TPD52L1_ENST00000524679.1_Missense_Mutation_p.E32Q|TPD52L1_ENST00000528193.1_Missense_Mutation_p.E61Q|TPD52L1_ENST00000532429.1_Missense_Mutation_p.E32Q|HDDC2_ENST00000608456.1_Intron	NM_003287.2	NP_003278.1	Q16890	TPD53_HUMAN	tumor protein D52-like 1	61					DNA fragmentation involved in apoptotic nuclear change|G2/M transition of mitotic cell cycle|induction of apoptosis|positive regulation of JNK cascade|positive regulation of MAP kinase activity	perinuclear region of cytoplasm	caspase activator activity|protein heterodimerization activity|protein homodimerization activity			endometrium(2)|large_intestine(2)|prostate(1)	5			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0265)		GTCAGCGAAAGAAAGGCATCT	0.418000													24	47					0	0	1	0	0
HIC2	23119	broad.mit.edu	37	22	21799914	21799914	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr22:21799914G>C	ENST00000443632.2	+	2	1102	c.730G>C	c.(730-732)Gag>Cag	p.E244Q	HIC2_ENST00000407464.2_Missense_Mutation_p.E244Q|HIC2_ENST00000407598.2_Missense_Mutation_p.E244Q			Q96JB3	HIC2_HUMAN	hypermethylated in cancer 2	244					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	focal adhesion|nucleus	DNA binding|protein C-terminus binding|zinc ion binding			NS(1)|endometrium(4)|large_intestine(1)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16	Melanoma(16;0.000465)|Ovarian(15;0.00438)|Colorectal(54;0.0968)	Lung SC(17;0.0262)|all_lung(157;0.205)				CTGCGAGCAGGAGCTGGGCTT	0.706000													18	12					0	0	1	0	0
TNK1	8711	broad.mit.edu	37	17	7290706	7290706	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:7290706G>C	ENST00000570896.1	+	11	1853	c.1407G>C	c.(1405-1407)aaG>aaC	p.K469N	TNK1_ENST00000311668.2_Missense_Mutation_p.K469N|TNK1_ENST00000576812.1_Missense_Mutation_p.K474N			Q13470	TNK1_HUMAN	tyrosine kinase, non-receptor, 1	474					protein autophosphorylation	membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(2)|pancreas(1)	16		Prostate(122;0.157)				GAGACAGAAAGAAGGCAAATC	0.562000													12	0					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32832589	32832589	+	Missense_Mutation	SNP	G	G	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:32832589G>T	ENST00000421745.2	+	72	14272	c.14138G>T	c.(14137-14139)cGg>cTg	p.R4713L		NM_016252.3	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	4713					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					GGATATGAACGGTCTAGAGGC	0.423000													77	56					4.75426e-39	5.20172e-39	1	1	0
CSRNP1	64651	broad.mit.edu	37	3	39184950	39184950	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:39184950C>T	ENST00000273153.5	-	5	1543	c.1366G>A	c.(1366-1368)Gag>Aag	p.E456K	CSRNP1_ENST00000514182.1_Missense_Mutation_p.E456K	NM_033027.3	NP_149016.2	Q96S65	CSRN1_HUMAN	cysteine-serine-rich nuclear protein 1	456					apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(3)|endometrium(4)|kidney(1)|large_intestine(5)|lung(3)|ovary(5)|skin(3)	24						TTGGCATTCTCATCCAGGACG	0.577000													23	34					0	0	1	0	0
MSMP	692094	broad.mit.edu	37	9	35754040	35754040	+	Silent	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr9:35754040G>C	ENST00000436428.2	-	1	226	c.87C>G	c.(85-87)ctC>ctG	p.L29L	RGP1_ENST00000378078.4_3'UTR|MSMP_ENST00000414286.1_Intron	NM_001044264.2	NP_001037729.1	Q1L6U9	MSMP_HUMAN	microseminoprotein, prostate associated	29						extracellular region				endometrium(2)|kidney(1)|lung(3)|prostate(3)	9						CTGGGTGCTGGAGGAGTAGAG	0.572000													5	183					0	0	1	0	0
ZNF513	130557	broad.mit.edu	37	2	27600471	27600471	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:27600471G>A	ENST00000323703.6	-	4	1765	c.1567C>T	c.(1567-1569)Cgg>Tgg	p.R523W	ZNF513_ENST00000407879.1_Missense_Mutation_p.R461W	NM_144631.5	NP_653232.3	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	523					regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding			endometrium(5)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)	17	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGTGGGCCCCGAGAGCTCAAA	0.627000													30	61					0	0	1	0	0
RILPL1	353116	broad.mit.edu	37	12	123984075	123984075	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:123984075C>G	ENST00000376874.4	-	3	704	c.469G>C	c.(469-471)Gag>Cag	p.E157Q	RILPL1_ENST00000340724.6_Missense_Mutation_p.E5Q	NM_178314.3	NP_847884.2	Q5EBL4	RIPL1_HUMAN	Rab interacting lysosomal protein-like 1	157					neuroprotection	cytosol				endometrium(1)|kidney(2)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	7	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000224)|Epithelial(86;0.00067)|all cancers(50;0.00836)|BRCA - Breast invasive adenocarcinoma(302;0.197)		CGCTCCCGCTCTGACATGCCT	0.557000													7	45					0	0	1	0	0
OR14C36	127066	broad.mit.edu	37	1	248512832	248512832	+	Silent	SNP	A	A	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:248512832A>T	ENST00000317861.1	+	1	756	c.756A>T	c.(754-756)tcA>tcT	p.S252S		NM_001001918.1	NP_001001918.1	Q8NHC7	O14CZ_HUMAN	olfactory receptor, family 14, subfamily C, member 36	252					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(4)|liver(2)|lung(20)|ovary(2)|prostate(3)|skin(7)|upper_aerodigestive_tract(2)	43						TCCTCAGTTCATGCTCTTCTG	0.512000													66	70					0	0	1	0	0
ZNF43	7594	broad.mit.edu	37	19	21990740	21990740	+	Missense_Mutation	SNP	T	T	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:21990740T>A	ENST00000594012.1	-	7	2595	c.2081A>T	c.(2080-2082)cAt>cTt	p.H694L	ZNF43_ENST00000595461.1_Missense_Mutation_p.H694L|ZNF43_ENST00000598381.1_Missense_Mutation_p.H694L|ZNF43_ENST00000354959.4_Missense_Mutation_p.H700L	NM_001256649.1|NM_001256651.1|NM_001256653.1|NM_001256654.1	NP_001243578.1|NP_001243580.1|NP_001243582.1|NP_001243583.1	P17038	ZNF43_HUMAN	zinc finger protein 43	700					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(16)|ovary(2)|prostate(3)|stomach(3)|upper_aerodigestive_tract(2)	51		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		CTCTCCAGTATGAATAATCTT	0.358000													37	64					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23893272	23893272	+	Missense_Mutation	SNP	C	C	T	rs138756911		TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr14:23893272C>T	ENST00000355349.3	-	23	2928	c.2766G>A	c.(2764-2766)atG>atA	p.M922I		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	922					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		GCCTCTCGTTCATCTCCTTCA	0.517000													72	14					0	0	1	0	0
TRIM67	440730	broad.mit.edu	37	1	231298823	231298823	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:231298823G>A	ENST00000444294.3	+	1	966	c.108G>A	c.(106-108)gtG>gtA	p.V36V	TRIM67_ENST00000366652.2_Silent_p.V36V|TRIM67_ENST00000366653.5_Silent_p.V36V|TRIM67_ENST00000449018.3_Silent_p.V36V	NM_001004342.3	NP_001004342.3	Q6ZTA4	TRI67_HUMAN	tripartite motif containing 67	36						cytoplasm|cytoskeleton	zinc ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29	Breast(184;0.0871)	all_cancers(173;0.189)|Prostate(94;0.167)				CCATCGCGGTGCAGACCCCGG	0.682000													9	6					0	0	1	0	0
PRAMEF2	65122	broad.mit.edu	37	1	12921210	12921210	+	Missense_Mutation	SNP	G	G	A	rs141943881	byFrequency	TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:12921210G>A	ENST00000240189.2	+	4	1088	c.1001G>A	c.(1000-1002)cGc>cAc	p.R334H		NM_023014.1	NP_075390.1	O60811	PRAM2_HUMAN	PRAME family member 2	334										breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(22)|prostate(6)|skin(3)|upper_aerodigestive_tract(4)	42	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CTGCTGTTCCGCATCAGTCTT	0.507000													6	412					0	0	1	0	0
AOAH	313	broad.mit.edu	37	7	36677472	36677472	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:36677472C>T	ENST00000431169.1	-	5	735	c.435G>A	c.(433-435)aaG>aaA	p.K145K	AOAH_ENST00000535891.1_Silent_p.K113K|AOAH_ENST00000258749.5_Silent_p.K145K	NM_001177506.1	NP_001170977.1	P28039	AOAH_HUMAN	acyloxyacyl hydrolase (neutrophil)	145					inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity			NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(2)|large_intestine(3)|lung(21)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	41						TCGGGGACTTCTTGACAATTT	0.433000													13	37					0	0	1	0	0
ZNF702P	79986	broad.mit.edu	37	19	53472582	53472582	+	RNA	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:53472582G>A	ENST00000600068.1	-	0	489				ZNF702P_ENST00000270443.4_RNA																							TAGCATTACTGAGGACTTTGT	0.368000													4	6					0	0	1	0	0
CERS6	253782	broad.mit.edu	37	2	169313123	169313123	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:169313123C>G	ENST00000305747.6	+	1	752	c.165C>G	c.(163-165)ttC>ttG	p.F55L	CERS6_ENST00000392687.4_Missense_Mutation_p.F55L	NM_203463.2	NP_982288.1	Q6ZMG9	CERS6_HUMAN	ceramide synthase 6	55						endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity										GGCTCATCTTCGAGAGGTAAG	0.652000													13	26					0	0	1	0	0
ANKRD44	91526	broad.mit.edu	37	2	197889969	197889969	+	Missense_Mutation	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:197889969C>A	ENST00000328737.2	-	17	1674	c.1598G>T	c.(1597-1599)gGa>gTa	p.G533V	ANKRD44_ENST00000450567.1_Missense_Mutation_p.G533V|ANKRD44_ENST00000337207.5_Missense_Mutation_p.G533V|ANKRD44_ENST00000282272.8_Missense_Mutation_p.G550V			Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	558							protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(20)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	45			OV - Ovarian serous cystadenocarcinoma(117;0.246)			TTCTTCAAATCCACTGTTTGT	0.393000													4	57					1.23904e-05	1.26766e-05	1	1	0
COL7A1	1294	broad.mit.edu	37	3	48623270	48623270	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:48623270C>G	ENST00000328333.8	-	29	3886	c.3779G>C	c.(3778-3780)gGa>gCa	p.G1260A	COL7A1_ENST00000454817.1_Missense_Mutation_p.G1260A	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	1260	Interrupted collagenous region.|Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CACCATCTCTCCAGGTTCCCC	0.587000													22	394					0	0	1	0	0
AKAP4	8852	broad.mit.edu	37	X	49957477	49957477	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chrX:49957477G>A	ENST00000376056.2	-	5	2010	c.1860C>T	c.(1858-1860)atC>atT	p.I620I	AKAP4_ENST00000358526.2_Silent_p.I629I|AKAP4_ENST00000376058.2_Silent_p.I246I|AKAP4_ENST00000481402.1_5'UTR|AKAP4_ENST00000376064.3_Silent_p.I620I			Q5JQC9	AKAP4_HUMAN	A kinase (PRKA) anchor protein 4	629					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			NS(2)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(6)|lung(14)|ovary(1)|skin(4)	41	Ovarian(276;0.236)					GCATTAGAACGATGTTTGACA	0.458000													83	23					0	0	1	0	0
SMPD4	55627	broad.mit.edu	37	2	130931230	130931230	+	Splice_Site	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:130931230C>T	ENST00000409031.1	-	4	1392		c.e4-1		SMPD4_ENST00000431183.2_Intron|SMPD4_ENST00000473720.1_Intron|SMPD4_ENST00000452225.2_Intron|SMPD4_ENST00000443958.2_Intron|SMPD4_ENST00000351288.6_Splice_Site|SMPD4_ENST00000339679.7_Splice_Site|SMPD4_ENST00000426662.2_Intron|SMPD4_ENST00000453750.1_Intron	NM_017951.4	NP_060421.2	Q9NXE4	NSMA3_HUMAN	sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)						sphingomyelin catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|trans-Golgi network	metal ion binding|protein binding|sphingomyelin phosphodiesterase activity|sphingomyelin phosphodiesterase D activity			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(17)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29	Colorectal(110;0.1)				Phosphatidylserine(DB00144)	TGTGCAGCTCCTGAAACAATG	0.602000													4	15					0	0	1	0	0
GALNTL6	442117	broad.mit.edu	37	4	173730548	173730548	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:173730548G>C	ENST00000506823.1	+	6	1247	c.590G>C	c.(589-591)cGa>cCa	p.R197P	GALNTL6_ENST00000508122.1_Missense_Mutation_p.R180P	NM_001034845.2	NP_001030017.2	Q49A17	GLTL6_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6	197	Catalytic subdomain A.					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(2)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	45						TACATGGCCCGATTTTCCAAA	0.448000													43	63					0	0	1	0	0
ACACB	32	broad.mit.edu	37	12	109671638	109671638	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:109671638G>A	ENST00000338432.7	+	30	4344	c.4225G>A	c.(4225-4227)Gag>Aag	p.E1409K	ACACB_ENST00000543201.1_Missense_Mutation_p.E75K|ACACB_ENST00000377854.5_Missense_Mutation_p.E1339K|ACACB_ENST00000377848.3_Missense_Mutation_p.E1409K			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	1409					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	CCTATACTCCGAGGATGACTG	0.607000													4	75					0	0	1	0	0
PCDH20	64881	broad.mit.edu	37	13	61987749	61987749	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr13:61987749C>T	ENST00000409186.1	-	5	2588	c.483G>A	c.(481-483)gcG>gcA	p.A161A	PCDH20_ENST00000409204.4_Silent_p.A161A			Q8N6Y1	PCD20_HUMAN	protocadherin 20	134	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(14)|liver(1)|lung(23)|ovary(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	58		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		TGCCGCTCCACGCAGTCCCTC	0.572000													27	13					0	0	1	0	0
NUP155	9631	broad.mit.edu	37	5	37326014	37326014	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:37326014C>G	ENST00000231498.3	-	19	2283	c.2080G>C	c.(2080-2082)Gag>Cag	p.E694Q	NUP155_ENST00000381843.2_Missense_Mutation_p.E635Q|NUP155_ENST00000513532.1_Missense_Mutation_p.E694Q	NM_153485.1	NP_705618.1	O75694	NU155_HUMAN	nucleoporin 155kDa	694					carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			endometrium(1)|kidney(16)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	62	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GCAGTGATCTCTCTGTTGCCA	0.313000													74	59					0	0	1	0	0
TRPA1	8989	broad.mit.edu	37	8	72975702	72975702	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr8:72975702C>T	ENST00000262209.4	-	5	864	c.657G>A	c.(655-657)agG>agA	p.R219R		NM_007332.2	NP_015628.2	O75762	TRPA1_HUMAN	transient receptor potential cation channel, subfamily A, member 1	219						integral to plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(26)|lung(44)|ovary(4)|prostate(6)|stomach(1)	98			Epithelial(68;0.223)		Menthol(DB00825)	ACTCACCAAACCTTAGTATTA	0.323000													44	33					0	0	1	0	0
PSD	5662	broad.mit.edu	37	10	104172193	104172193	+	Missense_Mutation	SNP	G	G	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr10:104172193G>T	ENST00000020673.5	-	6	2219	c.1693C>A	c.(1693-1695)Ctg>Atg	p.L565M	PSD_ENST00000406432.1_Missense_Mutation_p.L565M	NM_001270966.1|NM_002779.4	NP_001257895.1|NP_002770.3	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	565	SEC7.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(4)|endometrium(2)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		AGTCGGTACAGCCTCTTGGCC	0.627000													30	31					5.60225e-13	5.95439e-13	1	1	0
PRKD1	5587	broad.mit.edu	37	14	30135405	30135405	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr14:30135405G>C	ENST00000331968.5	-	3	642	c.413C>G	c.(412-414)aCc>aGc	p.T138S	PRKD1_ENST00000415220.2_Missense_Mutation_p.T138S	NM_002742.2	NP_002733.2	Q15139	KPCD1_HUMAN	protein kinase D1	138					cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|lung(32)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	78	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		GTCTTCAAAGGTGGCGGAAGC	0.413000													58	9					0	0	1	0	0
ST6GALNAC3	256435	broad.mit.edu	37	1	76877755	76877755	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:76877755G>A	ENST00000328299.3	+	3	424	c.276G>A	c.(274-276)caG>caA	p.Q92Q	ST6GALNAC3_ENST00000464140.1_3'UTR	NM_152996.2	NP_694541.2	Q8NDV1	SIA7C_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3	92					protein glycosylation	integral to Golgi membrane	sialyltransferase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(20)|ovary(3)|prostate(1)|skin(2)	36						TGGTTGGCCAGAAGGTGGGAA	0.443000													60	39					0	0	1	0	0
TRAPPC2L	51693	broad.mit.edu	37	16	88925045	88925045	+	Missense_Mutation	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr16:88925045C>A	ENST00000565504.1	+	2	76	c.52C>A	c.(52-54)Cgc>Agc	p.R18S	TRAPPC2L_ENST00000567312.1_Missense_Mutation_p.R18S|TRAPPC2L_ENST00000564365.1_5'UTR|TRAPPC2L_ENST00000567895.1_Intron|TRAPPC2L_ENST00000301021.3_Missense_Mutation_p.R18S|TRAPPC2L_ENST00000568583.1_Missense_Mutation_p.R18S|TRAPPC2L_ENST00000561840.1_Intron			Q9UL33	TPC2L_HUMAN	trafficking protein particle complex 2-like	18					ER to Golgi vesicle-mediated transport	endoplasmic reticulum|Golgi apparatus|perinuclear region of cytoplasm				lung(4)|pancreas(1)|skin(1)	6				BRCA - Breast invasive adenocarcinoma(80;0.0477)		CCTCTACATTCGCAGCACCCC	0.552000											OREG0024050	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	108	103					9.55279e-52	1.04889e-51	1	1	0
NPBWR2	2832	broad.mit.edu	37	20	62738020	62738020	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr20:62738020G>C	ENST00000369768.1	-	1	504	c.165C>G	c.(163-165)atC>atG	p.I55M		NM_005286.2	NP_005277.2	P48146	NPBW2_HUMAN	neuropeptides B/W receptor 2	55						plasma membrane	opioid receptor activity|protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	all_cancers(38;2.58e-11)|all_epithelial(29;6.4e-13)|Lung NSC(23;1.25e-09)|all_lung(23;4.21e-09)					CCACAGCACAGATCCCGGAGT	0.597000													25	69					0	0	1	0	0
USP34	9736	broad.mit.edu	37	2	61417469	61417469	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:61417469C>T	ENST00000398571.2	-	78	9886	c.9810G>A	c.(9808-9810)caG>caA	p.Q3270Q	AHSA2_ENST00000394457.3_3'UTR	NM_014709.3	NP_055524.3	Q70CQ2	UBP34_HUMAN	ubiquitin specific peptidase 34	3270					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(14)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(52)|ovary(8)|prostate(10)|skin(6)|urinary_tract(2)	138			Epithelial(17;0.229)			ACTGTAGGTTCTGATACTGGC	0.383000													28	71					0	0	1	0	0
TLR6	10333	broad.mit.edu	37	4	38829392	38829392	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:38829392C>G	ENST00000436693.2	-	2	1822	c.1703G>C	c.(1702-1704)aGa>aCa	p.R568T	TLR6_ENST00000381950.1_Missense_Mutation_p.R568T	NM_006068.4	NP_006059.2	Q9Y2C9	TLR6_HUMAN	toll-like receptor 6	568	LRRCT.				activation of NF-kappaB-inducing kinase activity|cellular response to diacyl bacterial lipopeptide|defense response to bacterium|detection of diacyl bacterial lipopeptide|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-6 biosynthetic process|positive regulation of JUN kinase activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	integral to plasma membrane|phagocytic vesicle membrane	lipopeptide binding|transmembrane receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TGGGCTTCCTCTATAACTTTC	0.433000													72	215					0	0	1	0	0
DERA	51071	broad.mit.edu	37	12	16189258	16189258	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:16189258G>A	ENST00000428559.2	+	8	1055	c.843G>A	c.(841-843)ctG>ctA	p.L281L	DERA_ENST00000532964.1_Silent_p.L238L|DERA_ENST00000532573.1_3'UTR|DERA_ENST00000526530.1_Silent_p.L193L	NM_015954.2	NP_057038.2	Q9Y315	DEOC_HUMAN	deoxyribose-phosphate aldolase (putative)	281					deoxyribonucleoside catabolic process|deoxyribonucleotide catabolic process	cytoplasm	deoxyribose-phosphate aldolase activity|protein binding			endometrium(1)|large_intestine(2)|lung(3)|skin(1)	7		Hepatocellular(102;0.121)				ATGAGTGGCTGAAGCCAGAAC	0.463000													12	50					0	0	1	0	0
CAPN1	823	broad.mit.edu	37	11	64978304	64978304	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:64978304C>T	ENST00000527323.1	+	20	2319	c.2079C>T	c.(2077-2079)gaC>gaT	p.D693D	CAPN1_ENST00000533129.1_Silent_p.D693D|CAPN1_ENST00000524773.1_Silent_p.D693D|CAPN1_ENST00000533820.1_Silent_p.D693D|CAPN1_ENST00000279247.6_Silent_p.D693D			P07384	CAN1_HUMAN	calpain 1, (mu/I) large subunit	693	Domain IV.|EF-hand 4.				positive regulation of cell proliferation|proteolysis	cytoplasm|plasma membrane	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|protein binding			breast(2)|endometrium(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(1)	13		Lung NSC(402;0.094)|Melanoma(852;0.16)		Lung(977;0.00168)|LUSC - Lung squamous cell carcinoma(976;0.00813)		AAACTCTGGACACAGATCTGG	0.502000													7	133					0	0	1	0	0
KIFC2	90990	broad.mit.edu	37	8	145694704	145694704	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr8:145694704C>T	ENST00000301332.2	+	11	1541	c.1164C>T	c.(1162-1164)ctC>ctT	p.L388L	KIFC2_ENST00000301331.5_Silent_p.L136L	NM_145754.2	NP_665697.1	Q96AC6	KIFC2_HUMAN	kinesin family member C2	388					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(7)|ovary(3)|prostate(3)|skin(2)|urinary_tract(1)	19	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			GCACTCAGCTCCCTGAGGGGC	0.672000													27	12					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179436318	179436318	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:179436318C>G	ENST00000589042.1	-	326	74765	c.74541G>C	c.(74539-74541)gaG>gaC	p.E24847D	TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.E22279D|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E15907D|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E15974D|TTN_ENST00000591111.1_Missense_Mutation_p.E23206D|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E15782D	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	23206	Fibronectin type-III 81.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTCCCGTTTCTCAACAATGT	0.423000													24	10					0	0	1	0	0
ZNF256	10172	broad.mit.edu	37	19	58452586	58452586	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:58452586C>G	ENST00000282308.3	-	3	1786	c.1590G>C	c.(1588-1590)caG>caC	p.Q530H	ZNF256_ENST00000598928.1_3'UTR	NM_005773.2	NP_005764.2	Q9Y2P7	ZN256_HUMAN	zinc finger protein 256	530					multicellular organismal development|negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(6)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0155)		GGCTGGAGCTCTGGCTAAAAA	0.453000													4	86					0	0	1	0	0
CREBRF	153222	broad.mit.edu	37	5	172550196	172550196	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:172550196G>C	ENST00000540014.1	+	9	2120	c.1801G>C	c.(1801-1803)Gat>Cat	p.D601H	CREBRF_ENST00000296953.2_Missense_Mutation_p.D599H			Q8IUR6	CE041_HUMAN	CREB3 regulatory factor	599							protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity										CCTCATTAAAGATACTCTCGG	0.353000													55	31					0	0	1	0	0
TTC40	54777	broad.mit.edu	37	10	134647015	134647015	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr10:134647015C>G	ENST00000368586.5	-	50	7064	c.6964G>C	c.(6964-6966)Gag>Cag	p.E2322Q	TTC40_ENST00000263170.5_Missense_Mutation_p.E483Q	NM_001200049.2	NP_001186978.2	Q8IYW2	CJ092_HUMAN	tetratricopeptide repeat domain 40	483										breast(1)|endometrium(5)|lung(19)|urinary_tract(3)	28						TCGGCAACCTCAGGCTGGACT	0.582000													9	175					0	0	1	0	0
BAZ2A	11176	broad.mit.edu	37	12	57007814	57007814	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:57007814G>A	ENST00000179765.5	-	5	948	c.749C>T	c.(748-750)tCa>tTa	p.S250L	BAZ2A_ENST00000379441.3_Missense_Mutation_p.S252L|BAZ2A_ENST00000549884.1_Missense_Mutation_p.S280L|BAZ2A_ENST00000551812.1_Missense_Mutation_p.S282L			Q9UIF9	BAZ2A_HUMAN	bromodomain adjacent to zinc finger domain, 2A	282					chromatin silencing at rDNA|DNA methylation|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	DNA binding|histone acetyl-lysine binding|ligand-dependent nuclear receptor binding|RNA binding|zinc ion binding			breast(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(15)|urinary_tract(1)	31						AGGAAGATGTGAAGGATCATC	0.512000													35	26					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56171380	56171380	+	Splice_Site	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr18:56171380C>T	ENST00000361673.3	-	11	6243	c.6030G>A	c.(6028-6030)gaG>gaA	p.E2010E		NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	2010	Alpha-type protein kinase.						ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						TAGGAATGATCCTGGCAGGGA	0.498000													4	86					0	0	1	0	0
TBC1D4	9882	broad.mit.edu	37	13	75873564	75873564	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr13:75873564G>A	ENST00000377636.3	-	17	3404	c.3058C>T	c.(3058-3060)Ctg>Ttg	p.L1020L	TBC1D4_ENST00000478591.1_5'UTR|TBC1D4_ENST00000431480.2_Silent_p.L1012L|TBC1D4_ENST00000377625.2_Silent_p.L957L|TBC1D4_ENST00000425511.1_Silent_p.L184L	NM_014832.2	NP_055647.2	O60343	TBCD4_HUMAN	TBC1 domain family, member 4	1020	Rab-GAP TBC.					cytoplasm	Rab GTPase activator activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(12)|lung(18)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)		CTCATGTGCAGAAGCAGGACT	0.493000													19	28					0	0	1	0	0
ANKS1A	23294	broad.mit.edu	37	6	34962168	34962168	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:34962168G>C	ENST00000360359.3	+	10	1530	c.1392G>C	c.(1390-1392)aaG>aaC	p.K464N	ANKS1A_ENST00000535627.1_Intron	NM_015245.2	NP_056060.2	Q92625	ANS1A_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1A	464						cytoplasm	protein binding			cervix(2)|endometrium(3)|large_intestine(4)|lung(16)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31						CAGAGACAAAGAAAGTGGTGT	0.468000													38	43					0	0	1	0	0
SNHG5	387066	broad.mit.edu	37	6	86387016	86387016	+	RNA	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:86387016C>G	ENST00000384338.1	-	0	70					NR_002743.2																						CGGTCCATCTCAGAAGCCAGA	0.323000													29	29					0	0	1	0	0
MTNR1A	4543	broad.mit.edu	37	4	187455565	187455565	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:187455565C>T	ENST00000307161.5	-	2	532	c.331G>A	c.(331-333)Gtc>Atc	p.V111I	RP11-215A19.2_ENST00000509111.1_Intron	NM_005958.3	NP_005949.1	P48039	MTR1A_HUMAN	melatonin receptor 1A	111					circadian rhythm|G-protein signaling, coupled to cyclic nucleotide second messenger|mating behavior	integral to plasma membrane	melatonin receptor activity	p.V111I(1)		breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	14		all_cancers(14;6.39e-56)|all_epithelial(14;1.48e-41)|all_lung(41;2.45e-15)|Lung NSC(41;7.26e-15)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00335)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|Renal(120;0.0183)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;7.63e-12)|BRCA - Breast invasive adenocarcinoma(30;6.68e-07)|GBM - Glioblastoma multiforme(59;3.44e-05)|LUSC - Lung squamous cell carcinoma(40;0.000106)|STAD - Stomach adenocarcinoma(60;0.000279)|READ - Rectum adenocarcinoma(43;0.159)	Melatonin(DB01065)|Ramelteon(DB00980)	GAGCCGATGACGCTCAGGCCC	0.517000													28	40					0	0	1	0	0
THAP4	51078	broad.mit.edu	37	2	242541376	242541376	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:242541376C>G	ENST00000407315.1	-	5	1980	c.1549G>C	c.(1549-1551)Gag>Cag	p.E517Q	THAP4_ENST00000497486.1_5'UTR|THAP4_ENST00000402136.1_Missense_Mutation_p.E105Q|THAP4_ENST00000402545.1_Missense_Mutation_p.E105Q	NM_015963.5	NP_057047.4	Q8WY91	THAP4_HUMAN	THAP domain containing 4	517							DNA binding|metal ion binding			kidney(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)	9		all_cancers(19;2.09e-34)|all_epithelial(40;2.09e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Ovarian(221;0.069)|Lung NSC(271;0.0886)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.2)		Epithelial(32;2.3e-33)|all cancers(36;8.99e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.68e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0844)		ATGCACAGCTCCTGCCCGTTC	0.647000													17	27					0	0	1	0	0
ELP4	26610	broad.mit.edu	37	11	31669361	31669361	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:31669361G>C	ENST00000395934.2	+	8	1007	c.1000G>C	c.(1000-1002)Gag>Cag	p.E334Q	ELP4_ENST00000350638.5_Missense_Mutation_p.E334Q|ELP4_ENST00000379163.5_Missense_Mutation_p.E335Q|Z83001.1_ENST00000429821.1_RNA			Q96EB1	ELP4_HUMAN	elongator acetyltransferase complex subunit 4	334					histone acetylation|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|Elongator holoenzyme complex|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(3)	20	Lung SC(675;0.225)					TATTGGTTCTGAGAGAGAAAC	0.403000													7	72					0	0	1	0	0
FRMD5	84978	broad.mit.edu	37	15	44166565	44166565	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr15:44166565C>G	ENST00000417257.1	-	14	1407	c.1231G>C	c.(1231-1233)Gat>Cat	p.D411H	FRMD5_ENST00000484674.1_Missense_Mutation_p.D317H|FRMD5_ENST00000402883.1_Missense_Mutation_p.D411H	NM_032892.3	NP_116281.2	Q7Z6J6	FRMD5_HUMAN	FERM domain containing 5	411						cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			breast(2)|cervix(1)|endometrium(2)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	14		all_cancers(109;2.29e-15)|all_epithelial(112;9.98e-13)|Lung NSC(122;4.89e-08)|all_lung(180;5.08e-07)|Melanoma(134;0.0275)		all cancers(107;8.63e-20)|GBM - Glioblastoma multiforme(94;3.63e-06)		TCATTGCTATCTGTCCGGCTG	0.592000													4	96					0	0	1	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76461434	76461434	+	Missense_Mutation	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr16:76461434C>A	ENST00000307431.8	+	5	858	c.473C>A	c.(472-474)cCt>cAt	p.P158H	CNTNAP4_ENST00000478060.1_Missense_Mutation_p.P134H|CNTNAP4_ENST00000377504.4_Missense_Mutation_p.P158H|CNTNAP4_ENST00000469589.1_3'UTR|CNTNAP4_ENST00000476707.1_Missense_Mutation_p.P162H	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	159	F5/8 type C.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						CGCTTCATCCCTTTGGAATGG	0.418000													69	59					7.59065e-32	8.26616e-32	1	1	0
DPY19L2P2	349152	broad.mit.edu	37	7	102912190	102912190	+	RNA	SNP	T	T	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:102912190T>G	ENST00000312132.4	-	0	2389																											TCTGGATAAATATGGAAGCGT	0.343000													7	39					0	0	1	0	0
NSD1	64324	broad.mit.edu	37	5	176637763	176637763	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:176637763G>C	ENST00000439151.2	+	5	2408	c.2363G>C	c.(2362-2364)cGa>cCa	p.R788P	NSD1_ENST00000347982.4_Missense_Mutation_p.R519P|NSD1_ENST00000361032.4_Missense_Mutation_p.R685P|NSD1_ENST00000354179.4_Missense_Mutation_p.R519P	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	788					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		CCCAAGTTCCGAAGTATAAAG	0.418000			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			23	53					0	0	1	0	0
ARHGAP17	55114	broad.mit.edu	37	16	24958917	24958917	+	Splice_Site	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr16:24958917C>G	ENST00000289968.6	-	14	1197		c.e14-1		ARHGAP17_ENST00000441763.2_Splice_Site|ARHGAP17_ENST00000303665.5_Splice_Site	NM_001006634.1	NP_001006635.1	Q68EM7	RHG17_HUMAN	Rho GTPase activating protein 17						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(13)|ovary(1)|urinary_tract(2)	30				GBM - Glioblastoma multiforme(48;0.0407)		GATCAAATATCTAGGGGTCAA	0.468000													5	72					0	0	1	0	0
ZBTB17	7709	broad.mit.edu	37	1	16269565	16269565	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:16269565G>A	ENST00000375733.2	-	13	2060	c.1822C>T	c.(1822-1824)Cac>Tac	p.H608Y	ZBTB17_ENST00000537142.1_Missense_Mutation_p.H526Y|ZBTB17_ENST00000375743.4_Missense_Mutation_p.H608Y			Q13105	ZBT17_HUMAN	zinc finger and BTB domain containing 17	608					negative regulation of cell cycle	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(4)|large_intestine(1)|lung(4)|ovary(2)|prostate(2)	15		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|Colorectal(212;4.12e-07)|COAD - Colon adenocarcinoma(227;2.43e-05)|BRCA - Breast invasive adenocarcinoma(304;9.97e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0649)		TCACCAGTGTGAATGATGATG	0.617000													38	29					0	0	1	0	0
KCNA4	3739	broad.mit.edu	37	11	30033396	30033396	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:30033396C>G	ENST00000328224.6	-	2	2063	c.830G>C	c.(829-831)aGa>aCa	p.R277T		NM_002233.3	NP_002224.1	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 4	277						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(39)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	78						TTCCTCTTCTCTCACAAAGCC	0.512000													21	22					0	0	1	0	0
DOCK9	23348	broad.mit.edu	37	13	99567688	99567688	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr13:99567688C>T	ENST00000376460.1	-	8	867	c.787G>A	c.(787-789)Gac>Aac	p.D263N	DOCK9_ENST00000339416.2_Missense_Mutation_p.D264N|DOCK9_ENST00000448493.2_Missense_Mutation_p.D275N|DOCK9_ENST00000442173.1_Missense_Mutation_p.D263N	NM_001130048.1|NM_015296.2	NP_001123520.1|NP_056111.1	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9	264	PH.				blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(18)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	59	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					ACTTCACTGTCTGCTGCCAAG	0.398000													36	21					0	0	1	0	0
OR2M7	391196	broad.mit.edu	37	1	248487040	248487040	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:248487040G>A	ENST00000317965.2	-	1	859	c.831C>T	c.(829-831)ttC>ttT	p.F277F		NM_001004691.1	NP_001004691.1	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M, member 7	277					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(6)|large_intestine(3)|lung(29)|skin(3)	42	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CGATGGTGTAGAATACAGACA	0.458000													50	57					0	0	1	0	0
RLF	6018	broad.mit.edu	37	1	40703421	40703421	+	Nonsense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:40703421C>G	ENST00000372771.4	+	8	3074	c.3047C>G	c.(3046-3048)tCa>tGa	p.S1016*		NM_012421.3	NP_036553.2	Q13129	RLF_HUMAN	rearranged L-myc fusion	1016					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(18)|lung(18)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(4)|urinary_tract(2)	68	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			AAACCCTGCTCAGATACAAAC	0.383000													89	46					0	0	1	0	0
HSPA8	3312	broad.mit.edu	37	11	122930347	122930347	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:122930347C>G	ENST00000534624.1	-	5	1230	c.954G>C	c.(952-954)gaG>gaC	p.E318D	HSPA8_ENST00000533540.1_Missense_Mutation_p.E172D|HSPA8_ENST00000526110.1_Missense_Mutation_p.E299D|HSPA8_ENST00000534319.1_Missense_Mutation_p.E82D|HSPA8_ENST00000532636.1_Missense_Mutation_p.E318D|HSPA8_ENST00000526862.1_5'UTR|HSPA8_ENST00000227378.3_Missense_Mutation_p.E318D|HSPA8_ENST00000453788.2_Missense_Mutation_p.E318D	NM_006597.4	NP_006588.1	P11142	HSP7C_HUMAN	heat shock 70kDa protein 8	318	Interaction with BAG1.				cellular membrane organization|interspecies interaction between organisms|mRNA metabolic process|negative regulation of transcription, DNA-dependent|neurotransmitter secretion|post-Golgi vesicle-mediated transport|protein folding|response to unfolded protein|transcription, DNA-dependent	cell surface|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|melanosome|plasma membrane|ribonucleoprotein complex	ATP binding|ATPase activity, coupled|protein binding			breast(1)|central_nervous_system(7)|endometrium(1)|kidney(9)|large_intestine(4)|lung(13)|upper_aerodigestive_tract(1)	36		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		GAAGGGCTTTCTCTACTGGGT	0.473000													32	7					0	0	1	0	0
TCEA2	6919	broad.mit.edu	37	20	62699426	62699426	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr20:62699426C>T	ENST00000395053.3	+	4	423	c.268C>T	c.(268-270)Cgg>Tgg	p.R90W	TCEA2_ENST00000465111.1_3'UTR|TCEA2_ENST00000361317.2_Missense_Mutation_p.R63W|TCEA2_ENST00000343484.5_Missense_Mutation_p.R90W			Q15560	TCEA2_HUMAN	transcription elongation factor A (SII), 2	90					regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription elongation, DNA-dependent	transcription elongation factor complex	DNA binding|protein binding|translation elongation factor activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)	12	all_cancers(38;3.45e-11)|all_epithelial(29;9.12e-13)|Lung NSC(23;2e-09)|all_lung(23;6.77e-09)					AGCCAGGGAGCGGGGGAGGGG	0.637000													10	47					0	0	1	0	0
SHROOM3	57619	broad.mit.edu	37	4	77700111	77700111	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:77700111C>T	ENST00000296043.6	+	11	6725	c.5772C>T	c.(5770-5772)ttC>ttT	p.F1924F	RP11-359D14.3_ENST00000449007.1_RNA	NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	1924	ASD2.				apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			ACCAGCACTTCGTGAAAATGA	0.567000													71	49					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128478774	128478774	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:128478774C>T	ENST00000325888.8	+	8	1589	c.1328C>T	c.(1327-1329)gCc>gTc	p.A443V	FLNC_ENST00000346177.6_Missense_Mutation_p.A443V	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	443					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						TACAGACCTGCCATGGAGGGG	0.637000													97	11					0	0	1	0	0
CHD5	26038	broad.mit.edu	37	1	6184142	6184142	+	Missense_Mutation	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:6184142C>A	ENST00000262450.3	-	31	4664	c.4565G>T	c.(4564-4566)gGg>gTg	p.G1522V	CHD5_ENST00000378021.1_Missense_Mutation_p.G379V	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1522					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		GCTGTACTTCCCGTTGACATG	0.632000													14	32					1.15088e-07	1.2026e-07	1	1	0
HIST1H4D	8360	broad.mit.edu	37	6	26189115	26189115	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:26189115C>G	ENST00000340756.2	-	1	189	c.190G>C	c.(190-192)Gaa>Caa	p.E64Q		NM_003539.3	NP_003530.1	P62805	H4_HUMAN	histone cluster 1, H4d	64			E -> Q (in a breast cancer sample; somatic mutation).		CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			breast(2)|endometrium(2)|large_intestine(2)|lung(1)|prostate(1)	8		all_hematologic(11;0.196)				ATTACATTTTCCAGGAAAACT	0.587000													49	26					0	0	1	0	0
KCNN4	3783	broad.mit.edu	37	19	44271761	44271761	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:44271761C>T	ENST00000262888.3	-	8	1613	c.1218G>A	c.(1216-1218)ctG>ctA	p.L406L		NM_002250.2	NP_002241.1	O15554	KCNN4_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	406					defense response	voltage-gated potassium channel complex	calcium-activated potassium channel activity|calmodulin binding			biliary_tract(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	15		Prostate(69;0.0352)			Clotrimazole(DB00257)|Halothane(DB01159)|Quinine(DB00468)	GCAGCTCAGTCAGGGCATCCA	0.607000													10	63					0	0	1	0	0
SLC4A10	57282	broad.mit.edu	37	2	162821638	162821638	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:162821638G>A	ENST00000375514.5	+	23	3344	c.3057G>A	c.(3055-3057)ttG>ttA	p.L1019L	SLC4A10_ENST00000446997.1_Silent_p.L1038L|SLC4A10_ENST00000421911.1_Silent_p.L1038L|SLC4A10_ENST00000415876.2_Silent_p.L1008L|SLC4A10_ENST00000272716.5_Silent_p.L1008L	NM_001178016.1	NP_001171487.1	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate transporter, member 10	1038					bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(35)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						TGGATGATTTGATGCCCGAGA	0.343000													12	26					0	0	1	0	0
MAGI3	260425	broad.mit.edu	37	1	114123165	114123165	+	Splice_Site	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:114123165C>T	ENST00000369615.1	+	3	497	c.435C>T	c.(433-435)tgC>tgT	p.C145C	MAGI3_ENST00000307546.9_Splice_Site_p.C145C|MAGI3_ENST00000486456.1_3'UTR|MAGI3_ENST00000369611.4_Splice_Site_p.C145C|MAGI3_ENST00000369617.4_Splice_Site_p.C145C	NM_152900.2	NP_690864.2	Q5TCQ9	MAGI3_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 3	145	Guanylate kinase-like.				apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(9)|ovary(3)|prostate(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	41	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTTTCTTAGGCACTACAAGGG	0.353000													42	46					0	0	1	0	0
LTN1	26046	broad.mit.edu	37	21	30365150	30365150	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr21:30365150G>C	ENST00000389194.2	-	1	120	c.115C>G	c.(115-117)Cag>Gag	p.Q39E	LTN1_ENST00000389195.2_Missense_Mutation_p.Q39E|LTN1_ENST00000361371.5_5'UTR	NM_015565.2	NP_056380.2	O94822	LTN1_HUMAN	listerin E3 ubiquitin protein ligase 1	0							ligase activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(12)|lung(19)|ovary(5)|pancreas(1)|prostate(2)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)	60						GCTGTACTCTGAGCACTCAGA	0.637000													11	27					0	0	1	0	0
KIAA0391	9692	broad.mit.edu	37	14	35592752	35592752	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr14:35592752G>A	ENST00000557565.1	+	2	682	c.301G>A	c.(301-303)Gaa>Aaa	p.E101K	KIAA0391_ENST00000534898.4_Missense_Mutation_p.E101K|KIAA0391_ENST00000605870.1_Intron|KIAA0391_ENST00000604948.1_Missense_Mutation_p.E6K|KIAA0391_ENST00000250377.7_Missense_Mutation_p.E6K|KIAA0391_ENST00000321130.10_Missense_Mutation_p.E101K|KIAA0391_ENST00000603544.1_Missense_Mutation_p.E101K|KIAA0391_ENST00000603588.1_Intron	NM_001282234.1	NP_001269163.1	O15091	MRRP3_HUMAN	KIAA0391	101					tRNA processing	mitochondrion				central_nervous_system(1)|endometrium(4)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	14	Breast(36;0.0545)|Hepatocellular(127;0.158)|Prostate(35;0.184)		Lung(238;2.93e-05)|LUAD - Lung adenocarcinoma(48;3.86e-05)|Epithelial(34;0.0114)|all cancers(34;0.0277)	GBM - Glioblastoma multiforme(112;0.0593)		TTCTCAAACTGAAGATCATGC	0.388000													32	9					0	0	1	0	0
THSD7A	221981	broad.mit.edu	37	7	11441440	11441440	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:11441440C>G	ENST00000423059.4	-	23	4644	c.4393G>C	c.(4393-4395)Gaa>Caa	p.E1465Q	AC004538.3_ENST00000445839.1_RNA	NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A		TSP type-1 15.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		GATTTTGTTTCTAACATCTGC	0.363000										HNSCC(18;0.044)			42	15					0	0	1	0	0
ARMC3	219681	broad.mit.edu	37	10	23292274	23292274	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr10:23292274G>A	ENST00000298032.5	+	13	1746	c.1662G>A	c.(1660-1662)ctG>ctA	p.L554L	ARMC3_ENST00000376528.4_Silent_p.L291L|ARMC3_ENST00000409049.3_Silent_p.L554L|ARMC3_ENST00000409983.3_Silent_p.L554L	NM_173081.3	NP_775104.2	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	554							binding			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(24)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						ATCTTTCCCTGAAATACAGCC	0.353000													57	77					0	0	1	0	0
DDB1	1642	broad.mit.edu	37	11	61071442	61071442	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:61071442G>A	ENST00000301764.7	-	22	3124	c.2727C>T	c.(2725-2727)atC>atT	p.I909I	DDB1_ENST00000450997.2_Silent_p.I220I	NM_001923.4	NP_001914.3	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1, 127kDa	909	Interaction with CDT1 and CUL4A.				cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	48						AGAGGGCCATGATGTTGTTGT	0.557000								Nucleotide excision repair (NER)					4	160					0	0	1	0	0
PDCD11	22984	broad.mit.edu	37	10	105198494	105198494	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr10:105198494C>T	ENST00000369797.3	+	27	4048	c.3954C>T	c.(3952-3954)atC>atT	p.I1318I		NM_014976.1	NP_055791.1	Q14690	RRP5_HUMAN	programmed cell death 11	1318					mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	64		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		TTAACTCCATCCAGGACATTA	0.512000													47	51					0	0	1	0	0
KDM3B	51780	broad.mit.edu	37	5	137762695	137762695	+	Missense_Mutation	SNP	G	G	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:137762695G>T	ENST00000314358.5	+	18	4643	c.4443G>T	c.(4441-4443)atG>atT	p.M1481I	KDM3B_ENST00000394866.1_Missense_Mutation_p.M1137I|KDM3B_ENST00000542866.1_Missense_Mutation_p.M513I	NM_016604.3	NP_057688	Q7LBC6	KDM3B_HUMAN	lysine (K)-specific demethylase 3B	1481					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(15)|liver(2)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	65						GGCAGCCAATGGTGCTCAAAC	0.493000													5	63					0.000157383	0.000159441	1	1	0
XDH	7498	broad.mit.edu	37	2	31587027	31587027	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:31587027C>G	ENST00000379416.3	-	24	2676	c.2628G>C	c.(2626-2628)caG>caC	p.Q876H		NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	876					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	TACTCACACTCTGAGAGAGAT	0.572000													23	52					0	0	1	0	0
CDH13	1012	broad.mit.edu	37	16	83378596	83378596	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr16:83378596G>A	ENST00000566620.1	+	6	1056	c.766G>A	c.(766-768)Gaa>Aaa	p.E256K	CDH13_ENST00000428848.3_Missense_Mutation_p.E217K|CDH13_ENST00000569454.1_3'UTR|CDH13_ENST00000268613.10_Missense_Mutation_p.E303K	NM_001220488.1|NM_001220489.1|NM_001220490.1|NM_001257.4	NP_001207417.1|NP_001207418.1|NP_001207419.1|NP_001248.1	P55290	CAD13_HUMAN	cadherin 13	256	Cadherin 2.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		CCACGTCATGGAAGGGTCACC	0.507000													35	80					0	0	1	0	0
C21orf58	54058	broad.mit.edu	37	21	47742640	47742640	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr21:47742640G>A	ENST00000291691.7	-	1	1149	c.13C>T	c.(13-15)Cgg>Tgg	p.R5W	C21orf58_ENST00000397685.4_5'UTR|C21orf58_ENST00000397680.1_Intron|C21orf58_ENST00000397682.3_5'UTR	NM_058180.3	NP_478060.2	P58505	CU058_HUMAN	chromosome 21 open reading frame 58	5										breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(1)|pancreas(1)	9	Breast(49;0.112)			Colorectal(79;0.239)		gcagggagccgagatcgcgcc	0.572000													6	5					0	0	1	0	0
HHIPL2	79802	broad.mit.edu	37	1	222700314	222700314	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:222700314G>A	ENST00000343410.6	-	7	1860	c.1802C>T	c.(1801-1803)tCa>tTa	p.S601L		NM_024746.3	NP_079022.2	Q6UWX4	HIPL2_HUMAN	HHIP-like 2	601					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			NS(2)|endometrium(8)|kidney(4)|large_intestine(7)|lung(28)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	59				GBM - Glioblastoma multiforme(131;0.0185)		ATCTCACCTTGAGGGGTCAAC	0.428000													9	11					0	0	1	0	0
FDCSP	260436	broad.mit.edu	37	4	71098715	71098715	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:71098715C>G	ENST00000317987.5	+	3	174	c.62C>G	c.(61-63)tCt>tGt	p.S21C		NM_152997.3	NP_694542.1	Q8NFU4	FDSCP_HUMAN	follicular dendritic cell secreted protein	21						extracellular region											CTTTAGGTCTCTCAAGACCAG	0.269000													4	83					0	0	1	0	0
RBM7	10179	broad.mit.edu	37	11	114278279	114278279	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:114278279C>G	ENST00000540163.1	+	5	1193	c.551C>G	c.(550-552)tCt>tGt	p.S184C	RBM7_ENST00000545678.1_Missense_Mutation_p.S64C|RBM7_ENST00000541475.1_3'UTR|RBM7_ENST00000544582.1_Intron|RBM7_ENST00000375490.5_Missense_Mutation_p.S185C|RP11-212D19.4_ENST00000544347.1_Intron			Q9Y580	RBM7_HUMAN	RNA binding motif protein 7	184					meiosis		nucleotide binding|protein binding|RNA binding	p.S184F(1)		NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	17		all_cancers(61;5.06e-12)|all_epithelial(67;5.3e-06)|all_hematologic(158;7.68e-05)|Acute lymphoblastic leukemia(157;0.000966)|Melanoma(852;0.00153)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Breast(348;0.0818)|Prostate(24;0.104)		BRCA - Breast invasive adenocarcinoma(274;2.56e-06)|Epithelial(105;4.17e-05)|all cancers(92;0.000348)		TTCAATCAGTCTTCAAGCTCC	0.423000													5	84					0	0	1	0	0
ITGA6	3655	broad.mit.edu	37	2	173337526	173337526	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:173337526C>G	ENST00000375221.2	+	6	1003	c.800C>G	c.(799-801)tCc>tGc	p.S267C	ITGA6_ENST00000264106.6_Missense_Mutation_p.S267C|ITGA6_ENST00000343713.4_Missense_Mutation_p.S223C|ITGA6_ENST00000409532.1_Missense_Mutation_p.S109C|ITGA6_ENST00000409080.1_Intron|ITGA6_ENST00000264107.7_Intron			P23229	ITA6_HUMAN	integrin, alpha 6	267					blood coagulation|cell adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter	integrin complex	protein binding|receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	44			OV - Ovarian serous cystadenocarcinoma(117;0.0979)			ACCAGCGTTTCCTATACAGAT	0.473000													51	49					0	0	1	0	0
AC015849.16	0	broad.mit.edu	37	17	34236484	34236484	+	RNA	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:34236484G>A	ENST00000587132.1	-	0	1543																											TGGAGGTTGGGGTACAAATTC	0.488000													17	31					0	0	1	0	0
CDH17	1015	broad.mit.edu	37	8	95186219	95186219	+	Nonsense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr8:95186219G>A	ENST00000027335.3	-	7	713	c.589C>T	c.(589-591)Cag>Tag	p.Q197*	CDH17_ENST00000450165.2_Nonsense_Mutation_p.Q197*|CDH17_ENST00000441892.2_Intron	NM_004063.3	NP_004054.3	Q12864	CAD17_HUMAN	cadherin 17, LI cadherin (liver-intestine)	197	Cadherin 2.					integral to membrane	calcium ion binding			NS(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(4)|stomach(2)	52	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			TTCAATTCCTGAGATCCTGTG	0.478000													23	106					0	0	1	0	0
TPO	7173	broad.mit.edu	37	2	1546277	1546277	+	Silent	SNP	T	T	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:1546277T>A	ENST00000337415.3	+	16	2794	c.2703T>A	c.(2701-2703)gcT>gcA	p.A901A	TPO_ENST00000497517.2_3'UTR|TPO_ENST00000349624.3_3'UTR|TPO_ENST00000345913.4_3'UTR|TPO_ENST00000346956.3_3'UTR|TPO_ENST00000329066.4_3'UTR|TPO_ENST00000382201.3_3'UTR			P07202	PERT_HUMAN	thyroid peroxidase	0					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GCAGAACAGCTTCATGTTCCC	0.512000													8	23					0	0	1	0	0
SCYL3	57147	broad.mit.edu	37	1	169828278	169828278	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:169828278G>C	ENST00000367771.6	-	11	1430	c.1216C>G	c.(1216-1218)Ctg>Gtg	p.L406V	SCYL3_ENST00000367772.4_Missense_Mutation_p.L406V|SCYL3_ENST00000367770.1_Missense_Mutation_p.L406V|SCYL3_ENST00000470238.1_5'UTR	NM_020423.6	NP_065156.5	Q8IZE3	PACE1_HUMAN	SCY1-like 3 (S. cerevisiae)						cell migration	Golgi apparatus|lamellipodium	ATP binding|protein binding|protein kinase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(5)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GGTCCAAGCAGAGAGACCAGC	0.473000													83	63					0	0	1	0	0
ARHGAP35	2909	broad.mit.edu	37	19	47492821	47492821	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:47492821G>C	ENST00000404338.3	+	4	3925	c.3925G>C	c.(3925-3927)Gag>Cag	p.E1309Q		NM_004491.4	NP_004482.4	Q9NRY4	RHG35_HUMAN	Rho GTPase activating protein 35	1309	Rho-GAP.				axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity										GGACCTGGCAGAGAAAGACTT	0.532000													37	32					0	0	1	0	0
CPAMD8	27151	broad.mit.edu	37	19	17038868	17038868	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:17038868G>A	ENST00000443236.1	-	25	3493	c.3462C>T	c.(3460-3462)gtC>gtT	p.V1154V		NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	1107						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						CGCCGTGTGGGACCCCCAGGG	0.632000													83	59					0	0	1	0	0
C1orf43	25912	broad.mit.edu	37	1	154192352	154192352	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:154192352C>G	ENST00000368521.5	-	2	326	c.128G>C	c.(127-129)cGa>cCa	p.R43P	C1orf43_ENST00000368518.1_Missense_Mutation_p.R43P|C1orf43_ENST00000350592.3_Intron|C1orf43_ENST00000368516.1_Intron|C1orf43_ENST00000368519.1_Missense_Mutation_p.R43P|C1orf43_ENST00000362076.4_Intron	NM_001098616.1	NP_001092086.1	Q9BWL3	CA043_HUMAN	chromosome 1 open reading frame 43	43						integral to membrane	coenzyme binding|oxidoreductase activity			cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)	10	all_lung(78;1.98e-30)|Lung NSC(65;2.87e-28)|Hepatocellular(266;0.0877)					AGGTCCCCTTCGAGATTTCAT	0.408000													7	28					0	0	1	0	0
REG1P	5969	broad.mit.edu	37	2	79363927	79363927	+	RNA	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:79363927C>T	ENST00000444841.1	-	0	411																											CGGTGGGGGTCATGGAGGCCA	0.502000													8	19					0	0	1	0	0
ATP1A3	478	broad.mit.edu	37	19	42474410	42474410	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:42474410C>G	ENST00000545399.1	-	18	2661	c.2508G>C	c.(2506-2508)aaG>aaC	p.K836N	ATP1A3_ENST00000602133.1_Missense_Mutation_p.K793N|ATP1A3_ENST00000543770.1_Missense_Mutation_p.K834N|ATP1A3_ENST00000302102.5_Missense_Mutation_p.K823N	NM_001256214.1	NP_001243143.1	P13637	AT1A3_HUMAN	ATPase, Na+/K+ transporting, alpha 3 polypeptide	823					ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(19)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	52						TGGGCTGTCTCTTCATGATGT	0.617000													34	46					0	0	1	0	0
ZNF786	136051	broad.mit.edu	37	7	148767661	148767661	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:148767661C>T	ENST00000316286.9	-	3	2217	c.1945G>A	c.(1945-1947)Ggc>Agc	p.G649S	ZNF786_ENST00000491431.1_Missense_Mutation_p.G735S|ZNF786_ENST00000451334.3_Missense_Mutation_p.G698S			Q8N393	ZN786_HUMAN	zinc finger protein 786	735					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|cervix(1)|kidney(1)|large_intestine(3)|lung(10)|prostate(2)|skin(2)|soft_tissue(1)|urinary_tract(2)	26	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			CCACAATCGCCACAGGCAAAG	0.527000													5	112					0	0	1	0	0
WDFY3	23001	broad.mit.edu	37	4	85611775	85611775	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:85611775G>C	ENST00000322366.6	-	60	9603	c.9196C>G	c.(9196-9198)Ctc>Gtc	p.L3066V	WDFY3_ENST00000295888.4_Missense_Mutation_p.L3083V			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	3083						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		ATTGCACAGAGAATCTGGCCC	0.488000													28	35					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51871412	51871412	+	Missense_Mutation	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr20:51871412C>A	ENST00000371497.5	+	2	2302	c.1415C>A	c.(1414-1416)aCc>aAc	p.T472N	TSHZ2_ENST00000329613.6_Missense_Mutation_p.T469N|TSHZ2_ENST00000603338.2_Missense_Mutation_p.T469N	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	472					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			CCAGAGGAAACCAGCAAGGAT	0.423000													57	162					5.5144e-22	5.94252e-22	1	1	0
KCNJ6	3763	broad.mit.edu	37	21	39212961	39212961	+	Splice_Site	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr21:39212961C>G	ENST00000609713.1	-	2	613	c.24G>C	c.(22-24)atG>atC	p.M8I	KCNJ6_ENST00000288309.6_Splice_Site_p.M8I	NM_002240.3	NP_002231.1	P48051	IRK6_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 6						synaptic transmission	Golgi apparatus|voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	22					Halothane(DB01159)	GCTACTCACTCATGGATTCTG	0.353000													271	154					0	0	1	0	0
HIST1H3B	8358	broad.mit.edu	37	6	26031885	26031885	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:26031885C>G	ENST00000244661.2	-	1	403	c.404G>C	c.(403-405)aGa>aCa	p.R135T		NM_003537.3	NP_003528.1	P68431	H31_HUMAN	histone cluster 1, H3b	135				Missing (in Ref. 2; AAA52651).	blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			breast(3)|central_nervous_system(10)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|skin(1)	25						CATTTACGCTCTTTCTCCGCG	0.453000													35	20					0	0	1	0	0
ANKHD1	54882	broad.mit.edu	37	5	139908299	139908299	+	Nonsense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:139908299C>G	ENST00000297183.6	+	29	5892	c.5768C>G	c.(5767-5769)tCa>tGa	p.S1923*	ANKHD1_ENST00000360839.2_Nonsense_Mutation_p.S1923*|ANKHD1_ENST00000544120.1_Nonsense_Mutation_p.S306*|ANKHD1-EIF4EBP3_ENST00000532219.1_Nonsense_Mutation_p.S1923*	NM_020690.5	NP_065741.3			ankyrin repeat and KH domain containing 1											breast(2)|endometrium(8)|kidney(6)|large_intestine(14)|lung(18)|ovary(5)|prostate(2)|skin(3)|urinary_tract(2)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTTTTACCCTCAGAGTCTGCT	0.488000													15	57					0	0	1	0	0
SACS	26278	broad.mit.edu	37	13	23912678	23912678	+	Silent	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr13:23912678C>G	ENST00000382298.3	-	10	5925	c.5337G>C	c.(5335-5337)tcG>tcC	p.S1779S	SACS_ENST00000402364.1_Silent_p.S1029S|SACS_ENST00000382292.3_Silent_p.S1779S	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	1779					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TAAAAAGTGGCGACTGTAAAT	0.418000													117	101					0	0	1	0	0
AKAP13	11214	broad.mit.edu	37	15	86118385	86118385	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr15:86118385C>G	ENST00000394518.2	+	6	781	c.686C>G	c.(685-687)tCc>tGc	p.S229C	AKAP13_ENST00000361243.2_Missense_Mutation_p.S229C	NM_001270546.1|NM_007200.4	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	229					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						GAACCAGACTCCTGGAGCAGT	0.428000													4	79					0	0	1	0	0
RARS	5917	broad.mit.edu	37	5	167915737	167915737	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:167915737G>A	ENST00000231572.3	+	2	230	c.176G>A	c.(175-177)cGa>cAa	p.R59Q	RARS_ENST00000538719.1_5'UTR	NM_002887.3	NP_002878.2	P54136	SYRC_HUMAN	arginyl-tRNA synthetase	59	Could be involved in the assembly of the multisynthetase complex.				arginyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	arginine-tRNA ligase activity|ATP binding|protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|ovary(2)|skin(1)|stomach(1)	22	Renal(175;0.000159)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0208)|all_neural(177;0.0227)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0693)|Epithelial(171;0.131)|OV - Ovarian serous cystadenocarcinoma(192;0.156)		AATATTCTTCGAAAGGTGAGT	0.343000													20	16					0	0	1	0	0
TTPAL	79183	broad.mit.edu	37	20	43118172	43118172	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr20:43118172C>G	ENST00000372904.3	+	6	1162	c.1019C>G	c.(1018-1020)tCc>tGc	p.S340C	TTPAL_ENST00000262605.4_Missense_Mutation_p.S340C|TTPAL_ENST00000372906.2_3'UTR	NM_024331.4	NP_077307.2	Q9BTX7	TTPAL_HUMAN	tocopherol (alpha) transfer protein-like	340						intracellular	transporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(2)|ovary(2)|skin(5)	18						CAGCTGTACTCCTGCTACTAG	0.537000													14	36					0	0	1	0	0
ADCY2	108	broad.mit.edu	37	5	7396424	7396424	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:7396424G>A	ENST00000338316.4	+	1	104	c.15G>A	c.(13-15)gcG>gcA	p.A5A		NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	5					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						GGCAGGAGGCGATGCGGCGCC	0.811000													12	2					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196729194	196729194	+	Silent	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:196729194G>C	ENST00000312428.6	-	41	7285	c.7185C>G	c.(7183-7185)gtC>gtG	p.V2395V		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2395	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						TAAACAGGAAGACACCCTGCA	0.378000													21	42					0	0	1	0	0
SYNPO2	171024	broad.mit.edu	37	4	119952333	119952333	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:119952333C>T	ENST00000307142.4	+	4	2599	c.2403C>T	c.(2401-2403)acC>acT	p.T801T	SYNPO2_ENST00000429713.2_Silent_p.T801T|SYNPO2_ENST00000434046.2_Silent_p.T801T|SYNPO2_ENST00000448416.2_Intron	NM_133477.2	NP_597734.2	Q9UMS6	SYNP2_HUMAN	synaptopodin 2	801	Pro-rich.					nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(18)|ovary(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						CAAAGGGCACCGTTGTCTCCT	0.572000													5	118					0	0	1	0	0
NEFM	4741	broad.mit.edu	37	8	24775357	24775357	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr8:24775357G>C	ENST00000221166.5	+	3	2771	c.1989G>C	c.(1987-1989)gaG>gaC	p.E663D	NEFM_ENST00000518131.1_Intron|NEFM_ENST00000521540.1_Intron|NEFM_ENST00000433454.2_Missense_Mutation_p.E287D|NEFM_ENST00000437366.2_Intron			P07197	NFM_HUMAN	neurofilament, medium polypeptide	663	6 X 13 AA approximate tandem repeats of K-S-P-V-[PS]-K-S-P-V-E-E-[KA]-[GAK].|Tail.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(3)|endometrium(7)|kidney(4)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|urinary_tract(1)	36		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		CAGTGGAAGAGAAAGGCAAGT	0.498000													4	72					0	0	1	0	0
TLN2	83660	broad.mit.edu	37	15	63097945	63097945	+	Silent	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr15:63097945G>C	ENST00000561311.1	+	50	6854	c.6624G>C	c.(6622-6624)ctG>ctC	p.L2208L	TLN2_ENST00000306829.6_Silent_p.L2208L			Q9Y4G6	TLN2_HUMAN	talin 2	2208					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			NS(3)|breast(6)|central_nervous_system(3)|endometrium(8)|kidney(8)|large_intestine(20)|lung(34)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)	99						CTGCCAACCTGAGCCGGAAAG	0.512000													15	31					0	0	1	0	0
GJC3	349149	broad.mit.edu	37	7	99526685	99526685	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:99526685C>T	ENST00000312891.2	-	1	558	c.559G>A	c.(559-561)Gag>Aag	p.E187K		NM_181538.2	NP_853516.1	Q8NFK1	CXG3_HUMAN	gap junction protein, gamma 3, 30.2kDa	187						connexon complex|integral to membrane				breast(1)|endometrium(1)|large_intestine(3)|lung(3)|ovary(1)	9	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					ATGGTCTTCTCAGAGGGGCGG	0.502000													71	93					0	0	1	0	0
EMC8	10328	broad.mit.edu	37	16	85814059	85814059	+	Silent	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr16:85814059C>A	ENST00000253457.3	-	4	643	c.399G>T	c.(397-399)acG>acT	p.T133T	EMC8_ENST00000435200.2_Intron	NM_006067.4	NP_006058.1			ER membrane protein complex subunit 8																		CGCAGTCCATCGTAAACTTGG	0.607000													15	17					4.7546e-09	5.00768e-09	1	1	0
KIAA1279	26128	broad.mit.edu	37	10	70775863	70775863	+	Silent	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr10:70775863C>G	ENST00000361983.4	+	7	1659	c.1557C>G	c.(1555-1557)ctC>ctG	p.L519L		NM_015634.3	NP_056449.1	Q96EK5	KBP_HUMAN	KIAA1279	519					cell differentiation|mitochondrial transport|nervous system development	mitochondrion	kinesin binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(1)	14						ACTACCAGCTCTTCTTAGACT	0.418000													58	62					0	0	1	0	0
ADD1	118	broad.mit.edu	37	4	2877658	2877658	+	Missense_Mutation	SNP	C	C	T	rs2295497	by1000genomes	TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:2877658C>T	ENST00000355842.3	+	3	879	c.16C>T	c.(16-18)Cgt>Tgt	p.R6C	ADD1_ENST00000398123.2_Missense_Mutation_p.R6C|ADD1_ENST00000513328.2_Missense_Mutation_p.R6C|ADD1_ENST00000503455.2_Missense_Mutation_p.R6C|ADD1_ENST00000264758.7_Missense_Mutation_p.R6C|ADD1_ENST00000398129.1_Missense_Mutation_p.R6C|ADD1_ENST00000446856.1_Missense_Mutation_p.R6C|ADD1_ENST00000398125.1_Missense_Mutation_p.R6C			P35611	ADDA_HUMAN	adducin 1 (alpha)	6			R -> C (in dbSNP:rs2295497).		actin filament bundle assembly|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|positive regulation of protein binding	cytosol|F-actin capping protein complex|nucleus|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding|transcription factor binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)	22				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TGGTGATTCTCGTGCTGCGGT	0.443000													58	108					0	0	1	0	0
RNF17	56163	broad.mit.edu	37	13	25433165	25433165	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr13:25433165G>A	ENST00000255324.5	+	26	3689	c.3637G>A	c.(3637-3639)Gaa>Aaa	p.E1213K	RNF17_ENST00000381921.1_Missense_Mutation_p.E1213K|RNF17_ENST00000339524.3_Missense_Mutation_p.E265K	NM_001184993.1|NM_031277.2	NP_001171922.1|NP_112567.2	Q9BXT8	RNF17_HUMAN	ring finger protein 17	1213					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding	p.E1213*(1)		NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(3)|skin(6)	36		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		AATGACAAATGAAATTCAAAG	0.308000													12	13					0	0	1	0	0
ZNF343	79175	broad.mit.edu	37	20	2463950	2463950	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr20:2463950C>T	ENST00000278772.4	-	6	2144	c.1657G>A	c.(1657-1659)Gag>Aag	p.E553K	RP4-734P14.4_ENST00000461548.1_Intron	NM_001282495.1|NM_001282496.1|NM_024325.4	NP_001269424.1|NP_001269425.1|NP_077301.4	Q6P1L6	ZN343_HUMAN	zinc finger protein 343	553					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(11)|skin(4)|upper_aerodigestive_tract(1)	25						CGGCCACACTCACTGCACACG	0.522000													43	55					0	0	1	0	0
CALCRL	10203	broad.mit.edu	37	2	188211114	188211114	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:188211114G>A	ENST00000409998.1	-	16	1964	c.1183C>T	c.(1183-1185)Ctg>Ttg	p.L395L	CALCRL_ENST00000410068.1_Silent_p.L395L|AC007319.1_ENST00000412276.1_RNA|CALCRL_ENST00000392370.3_Silent_p.L395L|AC007319.1_ENST00000453517.1_RNA			Q16602	CALRL_HUMAN	calcitonin receptor-like	395						integral to plasma membrane				endometrium(1)|large_intestine(7)|lung(21)|ovary(1)|prostate(1)|skin(1)	32			OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(96;0.227)			TTTCTTCTCAGAATTGCTTGA	0.353000													13	9					0	0	1	0	0
TTI1	9675	broad.mit.edu	37	20	36642019	36642019	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr20:36642019C>T	ENST00000373448.2	-	3	438	c.200G>A	c.(199-201)aGa>aAa	p.R67K	TTI1_ENST00000487362.1_Intron|TTI1_ENST00000449821.1_Missense_Mutation_p.R67K|TTI1_ENST00000373447.3_Missense_Mutation_p.R67K	NM_014657.1	NP_055472.1	O43156	TTI1_HUMAN	TELO2 interacting protein 1	67							binding			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	47						CAAACGCTCTCTTTTGGGACC	0.483000													87	180					0	0	1	0	0
KIF21B	23046	broad.mit.edu	37	1	200961509	200961509	+	Silent	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:200961509C>G	ENST00000332129.2	-	16	2602	c.2286G>C	c.(2284-2286)ctG>ctC	p.L762L	KIF21B_ENST00000360529.5_Silent_p.L762L|KIF21B_ENST00000422435.2_Silent_p.L762L|KIF21B_ENST00000461742.2_Silent_p.L762L	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	762					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						TCTGCTTCATCAGGGCCACCT	0.647000													42	37					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38976669	38976669	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:38976669G>A	ENST00000359357.3	+	87	12897	c.12643G>A	c.(12643-12645)Gag>Aag	p.E4215K	DNAH8_ENST00000441566.1_Missense_Mutation_p.E4179K					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TGGTGTGGGAGAGACCCGGGA	0.433000													6	136					0	0	1	0	0
SOX17	64321	broad.mit.edu	37	8	55372409	55372409	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr8:55372409C>G	ENST00000297316.4	+	2	1303	c.1099C>G	c.(1099-1101)Ctg>Gtg	p.L367V		NM_022454.3	NP_071899.1	Q9H6I2	SOX17_HUMAN	SRY (sex determining region Y)-box 17	367	Sox C-terminal.				angiogenesis|cardiac cell fate determination|endocardial cell differentiation|endocardium formation|endoderm formation|heart formation|heart looping|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell growth|outflow tract morphogenesis|positive regulation of transcription, DNA-dependent|protein destabilization|protein stabilization|regulation of embryonic development|renal system development|vasculogenesis|Wnt receptor signaling pathway	transcription factor complex	beta-catenin binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			endometrium(6)|kidney(1)|large_intestine(3)|lung(7)|prostate(1)	18		Lung NSC(129;0.109)|all_epithelial(80;0.176)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;1.9e-07)|Epithelial(17;1.7e-05)|all cancers(17;0.000159)			TGAACAGTATCTGCACTTCGT	0.667000													14	25					0	0	1	0	0
CAMTA1	23261	broad.mit.edu	37	1	7798069	7798069	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:7798069C>T	ENST00000303635.7	+	16	3916	c.3709C>T	c.(3709-3711)Cac>Tac	p.H1237Y	CAMTA1_ENST00000439411.2_Missense_Mutation_p.H1237Y	NM_015215.2	NP_056030.1	Q9Y6Y1	CMTA1_HUMAN	calmodulin binding transcription activator 1	1237					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(11)|lung(29)|ovary(5)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	85	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		CAGTGAGAGCCACAAAGATTA	0.468000			T	WWTR1	epitheliod hemangioendothelioma								85	55					0	0	1	0	0
ZC3HAV1	56829	broad.mit.edu	37	7	138764924	138764924	+	Nonsense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:138764924G>A	ENST00000242351.5	-	4	1079	c.763C>T	c.(763-765)Cag>Tag	p.Q255*	ZC3HAV1_ENST00000464606.1_Nonsense_Mutation_p.Q255*|ZC3HAV1_ENST00000471652.1_Nonsense_Mutation_p.Q255*	NM_020119.3	NP_064504.2	Q7Z2W4	ZCCHV_HUMAN	zinc finger CCCH-type, antiviral 1	255					response to virus	cytoplasm|nucleus	NAD+ ADP-ribosyltransferase activity|RNA binding|zinc ion binding			cervix(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|prostate(4)|skin(1)	37						TGGCTGCCCTGAAAGAACCGA	0.483000													13	226					0	0	1	0	0
EEF2	1938	broad.mit.edu	37	19	3977937	3977937	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:3977937G>C	ENST00000309311.6	-	12	2035	c.1947C>G	c.(1945-1947)atC>atG	p.I649M		NM_001961.3	NP_001952.1	P13639	EF2_HUMAN	eukaryotic translation elongation factor 2	649						cytosol|ribonucleoprotein complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity			endometrium(4)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	21		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|GBM - Glioblastoma multiforme(1328;0.0223)|STAD - Stomach adenocarcinoma(1328;0.18)		CAAAGCACCAGATCTTGCGGG	0.632000													35	56					0	0	1	0	0
CTCF	10664	broad.mit.edu	37	16	67650659	67650659	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr16:67650659C>T	ENST00000264010.4	+	5	1408	c.964C>T	c.(964-966)Cac>Tac	p.H322Y	CTCF_ENST00000401394.1_5'UTR	NM_006565.3	NP_006556.1	P49711	CTCF_HUMAN	CCCTC-binding factor (zinc finger protein)	322					chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			breast(6)|central_nervous_system(2)|cervix(1)|endometrium(34)|haematopoietic_and_lymphoid_tissue(7)|kidney(3)|large_intestine(9)|liver(1)|lung(11)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	79		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		TACTCGTCCTCACAAGTGCCC	0.488000													137	230					0	0	1	0	0
BTNL8	79908	broad.mit.edu	37	5	180335831	180335831	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:180335831C>G	ENST00000231229.4	+	2	529	c.295C>G	c.(295-297)Ctg>Gtg	p.L99V	BTNL8_ENST00000340184.4_Missense_Mutation_p.L99V|BTNL8_ENST00000508408.1_Missense_Mutation_p.L99V|BTNL8_ENST00000511704.1_Intron|BTNL8_ENST00000400707.3_Intron	NM_001159708.1|NM_024850.2	NP_001153180.1|NP_079126.1	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8	99	Ig-like V-type 1.					integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	28	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCGCATCTCTCTGAGGCTGGA	0.522000													11	180					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38768156	38768156	+	Nonsense_Mutation	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:38768156C>A	ENST00000449082.2	-	16	3027	c.3028G>T	c.(3028-3030)Gag>Tag	p.E1010*		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1010					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CCATCATCCTCCAAGTCATCA	0.552000													32	50					5.8336e-16	6.22876e-16	1	1	0
UBE2O	63893	broad.mit.edu	37	17	74398695	74398695	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:74398695G>C	ENST00000319380.7	-	4	738	c.674C>G	c.(673-675)tCc>tGc	p.S225C		NM_022066.3	NP_071349.3	Q9C0C9	UBE2O_HUMAN	ubiquitin-conjugating enzyme E2O	225							ATP binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	36						GGCGCCGTTGGATAGCTTCAG	0.557000													8	167					0	0	1	0	0
ZNF700	90592	broad.mit.edu	37	19	12060307	12060307	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:12060307C>G	ENST00000482090.1	+	3	1832	c.1414C>G	c.(1414-1416)Caa>Gaa	p.Q472E	ZNF763_ENST00000538752.1_Intron|ZNF700_ENST00000254321.5_Missense_Mutation_p.Q490E|ZNF763_ENST00000591944.1_Intron|CTD-2006C1.12_ENST00000586394.1_RNA|ZNF763_ENST00000590798.1_Intron			Q9H0M5	ZN700_HUMAN	zinc finger protein 700	490					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		ZNF700/MAST1_ENST00000251472(2)	breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(13)|pancreas(1)|prostate(1)|urinary_tract(1)	33						GAAGCACCTTCAAATTCATGA	0.398000													89	53					0	0	1	0	0
MMP2	4313	broad.mit.edu	37	16	55539267	55539267	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr16:55539267C>T	ENST00000219070.4	+	13	2405	c.1896C>T	c.(1894-1896)ttC>ttT	p.F632F	MMP2_ENST00000437642.2_Silent_p.F582F|MMP2_ENST00000570308.1_Silent_p.F556F|MMP2_ENST00000543485.1_Silent_p.F556F	NM_004530.4	NP_004521.1	P08253	MMP2_HUMAN	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	632	Hemopexin-like 4.|Required for inhibitor TIMP2 binding.				angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|liver(2)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	58		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	GCTACTTCTTCAAGGGTGCCT	0.507000													149	128					0	0	1	0	0
RNF168	165918	broad.mit.edu	37	3	196199275	196199275	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:196199275C>T	ENST00000318037.3	-	6	1725	c.1131G>A	c.(1129-1131)tcG>tcA	p.S377S		NM_152617.3	NP_689830.2	Q8IYW5	RN168_HUMAN	ring finger protein 168, E3 ubiquitin protein ligase	377					double-strand break repair|histone H2A K63-linked ubiquitination|positive regulation of DNA repair|response to ionizing radiation	nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|endometrium(2)|large_intestine(7)|lung(9)|ovary(1)	20	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;5.25e-24)|all cancers(36;5.47e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00348)		TCAGTAGGCACGACTCTTCAT	0.438000													37	93					0	0	1	0	0
CCT3	7203	broad.mit.edu	37	1	156288659	156288659	+	Splice_Site	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:156288659C>G	ENST00000295688.3	-	8	1039	c.759G>C	c.(757-759)caG>caC	p.Q253H	CCT3_ENST00000368261.3_Splice_Site_p.Q208H|CCT3_ENST00000472765.2_Splice_Site_p.Q208H|CCT3_ENST00000368259.2_Splice_Site_p.Q215H	NM_005998.4	NP_005989.3	P49368	TCPG_HUMAN	chaperonin containing TCP1, subunit 3 (gamma)	253					'de novo' posttranslational protein folding	cytoskeleton|cytosol|plasma membrane	ATP binding|unfolded protein binding			endometrium(4)|large_intestine(1)|liver(1)|lung(11)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	22	Hepatocellular(266;0.158)					AGAACCTTACCTGGCTTTCTC	0.428000													4	42					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179647612	179647612	+	Silent	SNP	C	C	T	rs147603843		TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:179647612C>T	ENST00000589042.1	-	18	3245	c.3021G>A	c.(3019-3021)gcG>gcA	p.A1007A	TTN_ENST00000342992.6_Silent_p.A1007A|TTN_ENST00000359218.5_Silent_p.A961A|TTN_ENST00000342175.6_Silent_p.A961A|TTN_ENST00000591111.1_Silent_p.A1007A|TTN_ENST00000460472.2_Silent_p.A961A|TTN_ENST00000360870.5_Silent_p.A1007A	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1007	Ig-like 3.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGCTGTCTTCCGCAAATGCTT	0.502000													4	77					0	0	1	0	0
AC015849.16	0	broad.mit.edu	37	17	34236532	34236532	+	RNA	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:34236532G>C	ENST00000587132.1	-	0	1495																											CATGGTTGGAGAAAGTTCAAT	0.483000													15	30					0	0	1	0	0
CHD5	26038	broad.mit.edu	37	1	6184081	6184081	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:6184081C>T	ENST00000262450.3	-	31	4725	c.4626G>A	c.(4624-4626)gtG>gtA	p.V1542V	CHD5_ENST00000378021.1_Silent_p.V399V	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1542					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		CCGAGGAGATCACCTCGCCCG	0.682000													18	19					0	0	1	0	0
CRYM	1428	broad.mit.edu	37	16	21288839	21288839	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr16:21288839G>C	ENST00000219599.3	-	4	502	c.237C>G	c.(235-237)ttC>ttG	p.F79L	CRYM_ENST00000415987.2_Missense_Mutation_p.F37L|CRYM_ENST00000396023.2_Missense_Mutation_p.F79L|CRYM_ENST00000543948.1_Missense_Mutation_p.F79L	NM_001888.3	NP_001879.1	Q14894	CRYM_HUMAN	crystallin, mu	79					negative regulation of transcription from RNA polymerase II promoter|sensory perception of sound|thyroid hormone transport	cytoplasm|nucleus|plasma membrane	NADP binding|protein homodimerization activity|thyroid hormone binding|transcription corepressor activity			large_intestine(1)|lung(3)	4				GBM - Glioblastoma multiforme(48;0.0573)	Levothyroxine(DB00451)	GGTCCTCGTAGAAGGTGACCA	0.607000													61	19					0	0	1	0	0
NDUFS1	4719	broad.mit.edu	37	2	206988950	206988950	+	Missense_Mutation	SNP	T	T	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:206988950T>C	ENST00000233190.6	-	19	2409	c.2143A>G	c.(2143-2145)Aca>Gca	p.T715A	NDUFS1_ENST00000457011.1_Missense_Mutation_p.T599A|NDUFS1_ENST00000455934.2_Missense_Mutation_p.T729A|NDUFS1_ENST00000440274.1_Missense_Mutation_p.T679A|NDUFS1_ENST00000423725.1_Missense_Mutation_p.T658A|NDUFS1_ENST00000432169.1_Missense_Mutation_p.T604A|NDUFS1_ENST00000449699.1_Missense_Mutation_p.T715A	NM_005006.6	NP_004997.4	P28331	NDUS1_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)						apoptosis|ATP metabolic process|mitochondrial electron transport, NADH to ubiquinone|reactive oxygen species metabolic process|regulation of mitochondrial membrane potential|transport	mitochondrial intermembrane space|mitochondrial respiratory chain complex I	2 iron, 2 sulfur cluster binding|4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|NADH dehydrogenase (ubiquinone) activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(7)|lung(15)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38					NADH(DB00157)	GCACCCTCTGTGACAGCTTTG	0.403000													62	31					0	0	1	0	0
BICD1	636	broad.mit.edu	37	12	32480823	32480823	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:32480823G>A	ENST00000548411.1	+	5	1615	c.1434G>A	c.(1432-1434)gaG>gaA	p.E478E	BICD1_ENST00000281474.5_Silent_p.E478E	NM_001003398.1	NP_001003398.1	Q96G01	BICD1_HUMAN	bicaudal D homolog 1 (Drosophila)	478					anatomical structure morphogenesis|intracellular mRNA localization|microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule|positive regulation of receptor-mediated endocytosis|protein localization to organelle|RNA processing|stress granule assembly|viral reproduction	cytoplasmic vesicle|cytoskeleton|cytosol|host cell viral assembly compartment|membrane|perinuclear region of cytoplasm|trans-Golgi network	cytoskeletal adaptor activity|dynactin binding|dynein binding|proteinase activated receptor binding|Rab GTPase binding|structural constituent of cytoskeleton			NS(1)|breast(2)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46	all_cancers(9;5.13e-11)|all_epithelial(9;2.71e-11)|all_lung(12;6.66e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0213)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0201)			AGAGTGGTGAGAAGATGGCCC	0.453000													28	45					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32626592	32626592	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:32626592C>T	ENST00000421745.2	+	8	1453	c.1319C>T	c.(1318-1320)tCa>tTa	p.S440L		NM_016252.3	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	440					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					CTTATTCTATCAGGAGACCCA	0.403000													6	85					0	0	1	0	0
CXCR5	643	broad.mit.edu	37	11	118765356	118765356	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:118765356C>G	ENST00000292174.4	+	2	1279	c.1103C>G	c.(1102-1104)tCt>tGt	p.S368C	BCL9L_ENST00000334801.3_3'UTR	NM_001716.4|NM_032966.2	NP_001707.1|NP_116743.1	P32302	CXCR5_HUMAN	chemokine (C-X-C motif) receptor 5	368					B cell activation|cellular component movement	integral to plasma membrane	C-X-C chemokine receptor activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(5)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.62e-05)		AATGCCACCTCTCTCACCACG	0.592000													24	3					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9067536	9067536	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:9067536G>C	ENST00000397910.4	-	3	20113	c.19910C>G	c.(19909-19911)tCc>tGc	p.S6637C		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6639	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GCCAGGCATGGATGTGGAAAC	0.502000													82	103					0	0	1	0	0
CLHC1	130162	broad.mit.edu	37	2	55403043	55403043	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:55403043C>T	ENST00000401408.1	-	13	1989	c.1644G>A	c.(1642-1644)caG>caA	p.Q548Q	CLHC1_ENST00000407122.1_Silent_p.Q548Q|CLHC1_ENST00000406076.1_Silent_p.Q426Q|CLHC1_ENST00000494539.1_5'UTR|CLHC1_ENST00000406437.2_Silent_p.Q99Q	NM_152385.2	NP_689598.2			clathrin heavy chain linker domain containing 1																		CAAAGCCATTCTGTGAACATA	0.373000													46	23					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578227	7578227	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:7578227C>T	ENST00000420246.2	-	6	754	c.622G>A	c.(622-624)Gac>Aac	p.D208N	TP53_ENST00000445888.2_Missense_Mutation_p.D208N|TP53_ENST00000413465.2_Missense_Mutation_p.D208N|TP53_ENST00000455263.2_Missense_Mutation_p.D208N|TP53_ENST00000269305.4_Missense_Mutation_p.D208N|TP53_ENST00000574684.1_Intron|TP53_ENST00000359597.4_Missense_Mutation_p.D208N	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	208	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		D -> E (in sporadic cancers; somatic mutation).|D -> G (in sporadic cancers; somatic mutation).|D -> H (in a sporadic cancer; somatic mutation).|D -> I (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|D -> N (in sporadic cancers; somatic mutation).|D -> V (in sporadic cancers; somatic mutation).|D -> Y (in a sporadic cancer; somatic mutation).|DD -> EY (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.?(5)|p.D207fs*6(2)|p.D208N(2)|p.D208fs*1(1)|p.D207_R213delDDRNTFR(1)|p.D208fs*38(1)|p.D207_V216del10(1)|p.D208I(1)|p.D208H(1)|p.E204fs*39(1)|p.D208Y(1)|p.E204_N210delEYLDDRN(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTGTTTCTGTCATCCAAATAC	0.537000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			3	37					0	0	1	0	0
TNFSF10	8743	broad.mit.edu	37	3	172241112	172241112	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:172241112G>C	ENST00000241261.2	-	1	185	c.63C>G	c.(61-63)atC>atG	p.I21M	TNFSF10_ENST00000420541.2_Missense_Mutation_p.I21M	NM_003810.3	NP_003801.1	P50591	TNF10_HUMAN	tumor necrosis factor (ligand) superfamily, member 10	21					activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of apoptosis by extracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane|soluble fraction	cytokine activity|metal ion binding|tumor necrosis factor receptor binding			breast(2)|cervix(1)|large_intestine(1)|lung(6)|ovary(1)|skin(4)	15	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.67e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			GCACTGTGAAGATCACGATCA	0.552000													8	97					0	0	1	0	0
SH2B3	10019	broad.mit.edu	37	12	111885584	111885584	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:111885584G>A	ENST00000341259.2	+	7	1718	c.1361G>A	c.(1360-1362)tGt>tAt	p.C454Y	SH2B3_ENST00000538307.1_Missense_Mutation_p.C252Y	NM_005475.2	NP_005466.1	Q9UQQ2	SH2B3_HUMAN	SH2B adaptor protein 3	454	SH2.				blood coagulation	cytosol	signal transducer activity			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	10						GGCGCCGCCTGTGATGTCCGG	0.647000													19	44					0	0	1	0	0
FDXR	2232	broad.mit.edu	37	17	72862345	72862345	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:72862345G>A	ENST00000455107.2	-	6	699	c.283C>T	c.(283-285)Cgg>Tgg	p.R95W	FDXR_ENST00000581530.1_Missense_Mutation_p.R139W|FDXR_ENST00000582944.1_Missense_Mutation_p.R131W|FDXR_ENST00000420580.2_Missense_Mutation_p.R99W|FDXR_ENST00000293195.5_Missense_Mutation_p.R139W|FDXR_ENST00000442102.2_Missense_Mutation_p.R182W|FDXR_ENST00000544854.1_Missense_Mutation_p.R87W|FDXR_ENST00000413947.2_Missense_Mutation_p.R170W|FDXR_ENST00000581969.1_5'UTR|FDXR_ENST00000583917.1_Missense_Mutation_p.R140W			P22570	ADRO_HUMAN	ferredoxin reductase	139					cholesterol metabolic process|electron transport chain|steroid biosynthetic process|transport	mitochondrial matrix	ferredoxin-NADP+ reductase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(9)|prostate(1)|skin(1)	16	all_lung(278;0.172)|Lung NSC(278;0.207)					TCCAGGGCCCGATGGTCCTCT	0.642000													4	65					0	0	1	0	0
THRSP	7069	broad.mit.edu	37	11	77774998	77774998	+	Missense_Mutation	SNP	T	T	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:77774998T>C	ENST00000281030.2	+	1	92	c.71T>C	c.(70-72)gTg>gCg	p.V24A	NDUFC2-KCTD14_ENST00000528251.1_Intron|NDUFC2-KCTD14_ENST00000530054.1_Intron	NM_003251.3	NP_003242.1	Q92748	THRSP_HUMAN	thyroid hormone responsive	24					lipid biosynthetic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus				breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	7	all_cancers(14;2.23e-19)|all_epithelial(13;7.49e-22)|Breast(9;6.38e-17)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;2.15e-25)			GCAGCCGAGGTGCACAACATG	0.612000													33	731					0	0	1	0	0
ARHGAP31	57514	broad.mit.edu	37	3	119134180	119134180	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:119134180C>G	ENST00000264245.4	+	12	3936	c.3404C>G	c.(3403-3405)tCt>tGt	p.S1135C		NM_020754.2	NP_065805.2	Q2M1Z3	RHG31_HUMAN	Rho GTPase activating protein 31	1135					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(3)|large_intestine(11)|lung(29)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	67						ATGCAGGTCTCTGAGCCAGGA	0.522000													35	29					0	0	1	0	0
HIST1H2BD	3017	broad.mit.edu	37	6	26158469	26158469	+	Silent	SNP	G	G	A	rs145666937	byFrequency	TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:26158469G>A	ENST00000289316.2	+	1	96	c.72G>A	c.(70-72)aaG>aaA	p.K24K	HIST1H2BD_ENST00000377777.4_Silent_p.K24K	NM_138720.2	NP_619790.1	P58876	H2B1D_HUMAN	histone cluster 1, H2bd	24					nucleosome assembly	nucleosome|nucleus	DNA binding	p.K24K(1)		breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	24						AGGCTCAGAAGAAGGACGGGA	0.537000													84	55					0	0	1	0	0
PPL	5493	broad.mit.edu	37	16	4934105	4934105	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr16:4934105C>G	ENST00000345988.2	-	22	4640	c.4551G>C	c.(4549-4551)caG>caC	p.Q1517H	PPL_ENST00000590782.2_Missense_Mutation_p.Q1515H	NM_002705.4	NP_002696	O60437	PEPL_HUMAN	periplakin	1517					keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			breast(6)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(12)|lung(12)|ovary(4)|prostate(5)|skin(3)|stomach(1)|urinary_tract(2)	62						TCTTGAGCCTCTGGATCTCTT	0.617000													27	16					0	0	1	0	0
DIS3L	115752	broad.mit.edu	37	15	66618326	66618326	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr15:66618326G>A	ENST00000319194.5	+	12	1837	c.1576G>A	c.(1576-1578)Gaa>Aaa	p.E526K	DIS3L_ENST00000441424.2_3'UTR|DIS3L_ENST00000319212.4_Missense_Mutation_p.E609K|RP11-352G18.2_ENST00000565993.1_RNA	NM_133375.3	NP_588616.1	Q8TF46	DI3L1_HUMAN	DIS3 mitotic control homolog (S. cerevisiae)-like	609					rRNA catabolic process	cytoplasm|exosome (RNase complex)	exonuclease activity|protein binding|ribonuclease activity|RNA binding			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						TGATATTCCAGAATTCAAAGA	0.453000													5	133					0	0	1	0	0
MCM4	4173	broad.mit.edu	37	8	48874719	48874719	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr8:48874719G>A	ENST00000262105.2	+	3	551	c.342G>A	c.(340-342)caG>caA	p.Q114Q	MCM4_ENST00000523944.1_Silent_p.Q114Q	NM_005914.3	NP_005905.2	P33991	MCM4_HUMAN	minichromosome maintenance complex component 4	114					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			biliary_tract(1)|breast(1)|endometrium(7)|kidney(4)|large_intestine(5)|lung(16)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	44		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00327)|all_lung(136;0.00354)				CTGTGAGACAGAGGCCTGACC	0.547000													9	78					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577099	7577099	+	Missense_Mutation	SNP	C	C	G	rs121912660		TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:7577099C>G	ENST00000420246.2	-	8	971	c.839G>C	c.(838-840)aGa>aCa	p.R280T	TP53_ENST00000445888.2_Missense_Mutation_p.R280T|TP53_ENST00000413465.2_Intron|TP53_ENST00000455263.2_Missense_Mutation_p.R280T|TP53_ENST00000269305.4_Missense_Mutation_p.R280T|TP53_ENST00000359597.4_Missense_Mutation_p.R280T	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	280	Interaction with AXIN1 (By similarity).|Interaction with DNA.|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		R -> G (in sporadic cancers; somatic mutation).|R -> I (in sporadic cancers; somatic mutation).|R -> K (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in a sporadic cancer; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).|R -> T (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R280T(65)|p.R280K(49)|p.R280I(16)|p.0?(8)|p.?(2)|p.R280_D281delRD(2)|p.A276_R283delACPGRDRR(1)|p.C275fs*20(1)|p.A276fs*64(1)|p.L265_K305del41(1)|p.G279_R280delGR(1)|p.F270_D281del12(1)|p.G279fs*59(1)|p.D281fs*24(1)|p.R280fs*62(1)|p.S269fs*21(1)|p.V272_K292del21(1)|p.C275_R283delCACPGRDRR(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCGCCGGTCTCTCCCAGGACA	0.542000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			15	4					0	0	1	0	0
DAB2	1601	broad.mit.edu	37	5	39376112	39376112	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:39376112G>A	ENST00000545653.1	-	12	2701	c.2171C>T	c.(2170-2172)tCa>tTa	p.S724L	DAB2_ENST00000509337.1_Missense_Mutation_p.S724L|DAB2_ENST00000320816.6_Missense_Mutation_p.S745L|DAB2_ENST00000339788.6_Missense_Mutation_p.S527L	NM_001244871.1	NP_001231800.1	P98082	DAB2_HUMAN	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	745	Required for interaction with MYO6 (By similarity).				cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(9)|lung(19)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	47	all_lung(31;0.000197)		Epithelial(62;0.137)			GGCTTGTGATGAACCAAAAGA	0.418000													84	65					0	0	1	0	0
CLSTN2	64084	broad.mit.edu	37	3	140167465	140167465	+	Missense_Mutation	SNP	G	G	A	rs142015908		TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:140167465G>A	ENST00000458420.3	+	6	1082	c.892G>A	c.(892-894)Gtc>Atc	p.V298I		NM_022131.2	NP_071414.2	Q9H4D0	CSTN2_HUMAN	calsyntenin 2	298					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|liver(1)|lung(42)|pancreas(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	87						CCTCCAGATCGTCACAGAGCT	0.537000										HNSCC(16;0.037)			5	147					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1271981	1271981	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:1271981C>T	ENST00000447027.1	+	31	13938	c.13880C>T	c.(13879-13881)aCa>aTa	p.T4627I	MUC5B_ENST00000529681.1_Missense_Mutation_p.T4624I			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	4624	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		acaaccaccacacccacaacc	0.647000													43	3					0	0	1	0	0
XAB2	56949	broad.mit.edu	37	19	7684654	7684654	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:7684654C>T	ENST00000358368.4	-	18	2522	c.2485G>A	c.(2485-2487)Gag>Aag	p.E829K	XAB2_ENST00000534844.1_Missense_Mutation_p.E826K	NM_020196.2	NP_064581.2	Q9HCS7	SYF1_HUMAN	XPA binding protein 2	829					transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	catalytic step 2 spliceosome|nucleoplasm	protein binding			breast(1)|central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(11)|prostate(1)|skin(2)|urinary_tract(1)	26						AGGTCCATCTCGTCCTCGTCC	0.701000								Direct reversal of damage;Nucleotide excision repair (NER)					11	634					0	0	1	0	0
GON4L	54856	broad.mit.edu	37	1	155823429	155823429	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:155823429G>A	ENST00000437809.1	-	2	265	c.143C>T	c.(142-144)tCc>tTc	p.S48F	GON4L_ENST00000361040.5_Missense_Mutation_p.S48F|GON4L_ENST00000271883.5_Missense_Mutation_p.S48F|GON4L_ENST00000368331.1_Missense_Mutation_p.S48F|GON4L_ENST00000471341.1_5'UTR	NM_001282856.1	NP_001269785.1	Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	48					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					TGGATCCCAGGATAGTGACAC	0.468000													5	109					0	0	1	0	0
ZNF589	51385	broad.mit.edu	37	3	48310141	48310141	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:48310141C>T	ENST00000354698.3	+	4	1032	c.960C>T	c.(958-960)atC>atT	p.I320I	ZNF589_ENST00000427617.2_Intron|ZNF589_ENST00000440261.2_Intron|ZNF589_ENST00000412564.1_Intron	NM_016089.2	NP_057173.2	Q86UQ0	ZN589_HUMAN	zinc finger protein 589	320					regulation of transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|skin(1)	4				BRCA - Breast invasive adenocarcinoma(193;0.000649)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CATACCTCATCAGACATCAGA	0.507000													67	66					0	0	1	0	0
MTMR12	54545	broad.mit.edu	37	5	32230022	32230022	+	Silent	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:32230022G>C	ENST00000382142.3	-	16	2276	c.2106C>G	c.(2104-2106)ctC>ctG	p.L702L	MTMR12_ENST00000264934.5_Silent_p.L592L|MTMR12_ENST00000280285.5_Silent_p.L648L	NM_001040446.1	NP_001035536.1	Q9C0I1	MTMRC_HUMAN	myotubularin related protein 12	702						cytoplasm	phosphatase activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						ACAAAGACGAGAGGCGGGCAG	0.572000													107	83					0	0	1	0	0
STON1	11037	broad.mit.edu	37	2	48809463	48809463	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:48809463C>T	ENST00000309835.3	+	1	1701	c.1691C>T	c.(1690-1692)tCc>tTc	p.S564F	STON1_ENST00000404752.1_Missense_Mutation_p.S564F|STON1-GTF2A1L_ENST00000394754.1_Missense_Mutation_p.S564F|STON1-GTF2A1L_ENST00000402114.2_Missense_Mutation_p.S564F|STON1-GTF2A1L_ENST00000394751.3_Missense_Mutation_p.S564F|STON1-GTF2A1L_ENST00000405008.1_Missense_Mutation_p.S564F|STON1-GTF2A1L_ENST00000309827.2_Missense_Mutation_p.S564F|STON1_ENST00000406226.1_Missense_Mutation_p.S564F					stonin 1											NS(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(19)|prostate(3)|skin(2)	37		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			TCCTTAAGGTCCTGTGACAAT	0.488000													26	76					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186147874	186147874	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:186147874G>A	ENST00000271588.4	+	104	16499	c.16270G>A	c.(16270-16272)Gag>Aag	p.E5424K	HMCN1_ENST00000367492.2_Intron	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	5424					response to stimulus|visual perception	basement membrane	calcium ion binding	p.E5424Q(1)		NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						TGAAGGCTCTGAGGCAAGCCA	0.438000													66	83					0	0	1	0	0
RSBN1	54665	broad.mit.edu	37	1	114354874	114354874	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:114354874C>T	ENST00000261441.5	-	1	224	c.161G>A	c.(160-162)gGa>gAa	p.G54E		NM_018364.3	NP_060834.2	Q5VWQ0	RSBN1_HUMAN	round spermatid basic protein 1	54						nucleus				breast(1)|endometrium(2)|large_intestine(4)|lung(16)|ovary(1)|prostate(3)|urinary_tract(2)	29	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCGCACCGCTCCGACCTGCGC	0.682000													29	126					0	0	1	0	0
TMCO4	255104	broad.mit.edu	37	1	20107215	20107215	+	Nonsense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:20107215G>A	ENST00000294543.6	-	4	278	c.37C>T	c.(37-39)Cag>Tag	p.Q13*	TMCO4_ENST00000375122.2_Nonsense_Mutation_p.Q13*|TMCO4_ENST00000375127.1_Nonsense_Mutation_p.Q13*	NM_181719.4	NP_859070.3	Q5TGY1	TMCO4_HUMAN	transmembrane and coiled-coil domains 4	13						integral to membrane				biliary_tract(1)|breast(2)|endometrium(2)|kidney(1)|lung(11)|skin(1)|upper_aerodigestive_tract(1)	19		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00708)|COAD - Colon adenocarcinoma(152;2.28e-05)|BRCA - Breast invasive adenocarcinoma(304;5.8e-05)|Kidney(64;0.000367)|GBM - Glioblastoma multiforme(114;0.000377)|KIRC - Kidney renal clear cell carcinoma(64;0.00459)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0862)|Lung(427;0.223)		AGAGGCTGCTGAGGCAGCCTC	0.607000													6	35					0	0	1	0	0
EHF	26298	broad.mit.edu	37	11	34680094	34680094	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:34680094C>T	ENST00000257831.3	+	8	743	c.622C>T	c.(622-624)Cac>Tac	p.H208Y	EHF_ENST00000531794.1_Missense_Mutation_p.H230Y|EHF_ENST00000530286.1_Missense_Mutation_p.H208Y|EHF_ENST00000533754.1_Missense_Mutation_p.H208Y|EHF_ENST00000450654.2_Missense_Mutation_p.H185Y	NM_012153.5	NP_036285.2	Q9NZC4	EHF_HUMAN	ets homologous factor	208					cell proliferation|epithelial cell differentiation|multicellular organismal development|positive regulation of transcription, DNA-dependent		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		NFIA/EHF(2)	autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(3)|lung(8)|upper_aerodigestive_tract(1)	17		all_hematologic(20;0.117)	Epithelial(1;0.055)|all cancers(1;0.137)|STAD - Stomach adenocarcinoma(6;0.235)			GAGAGGGACTCACTTATGGGA	0.463000													55	8					0	0	1	0	0
SOD2	6648	broad.mit.edu	37	6	160105983	160105983	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:160105983G>A	ENST00000538183.2	-	4	586	c.426C>T	c.(424-426)gtC>gtT	p.V142V	SOD2_ENST00000367054.2_Silent_p.V103V|SOD2_ENST00000337404.4_Silent_p.V103V|SOD2_ENST00000444946.2_Intron|SOD2_ENST00000546087.1_Silent_p.V96V|SOD2_ENST00000367055.4_Silent_p.V142V	NM_000636.2	NP_000627.2	P04179	SODM_HUMAN	superoxide dismutase 2, mitochondrial						age-dependent response to reactive oxygen species|negative regulation of neuron apoptosis|oxygen homeostasis|protein homotetramerization|regulation of transcription from RNA polymerase II promoter|release of cytochrome c from mitochondria|removal of superoxide radicals|vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure		manganese ion binding|superoxide dismutase activity	p.V142V(1)		central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(3)|skin(1)	14		Breast(66;0.000776)|Ovarian(120;0.0303)|Prostate(117;0.103)		OV - Ovarian serous cystadenocarcinoma(65;1.4e-18)|BRCA - Breast invasive adenocarcinoma(81;5.77e-06)		CTGAGCCTTGGACACCAACAG	0.458000													90	57					0	0	1	0	0
MAP3K9	4293	broad.mit.edu	37	14	71267619	71267619	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr14:71267619G>A	ENST00000554752.2	-	2	584	c.585C>T	c.(583-585)ttC>ttT	p.F195F	MAP3K9_ENST00000381250.4_Silent_p.F195F|MAP3K9_ENST00000555993.2_Silent_p.F195F	NM_001284230.1	NP_001271159.1	P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase 9	195	Protein kinase.				activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(1)|skin(3)|stomach(2)	46				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		TCAGCATGGCGAAGAGCTTGG	0.542000													70	18					0	0	1	0	0
TBCE	6905	broad.mit.edu	37	1	235577754	235577754	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:235577754G>A	ENST00000543662.1	+	4	298	c.192G>A	c.(190-192)ccG>ccA	p.P64P	TBCE_ENST00000366601.3_Silent_p.P64P|TBCE_ENST00000406207.1_Silent_p.P64P|TBCE_ENST00000472011.1_3'UTR			Q15813	TBCE_HUMAN	tubulin folding cofactor E	64	CAP-Gly.				'de novo' posttranslational protein folding|post-chaperonin tubulin folding pathway	cytoplasm|microtubule|nucleus|plasma membrane	chaperone binding			NS(1)|endometrium(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	14	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00192)|Prostate(94;0.0294)|all_epithelial(177;0.155)|Lung SC(1967;0.238)	OV - Ovarian serous cystadenocarcinoma(106;2.56e-05)			CCAGGCACCCGACAGGAGGAT	0.388000													56	49					0	0	1	0	0
IRF8	3394	broad.mit.edu	37	16	85946818	85946818	+	Missense_Mutation	SNP	T	T	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr16:85946818T>C	ENST00000268638.5	+	5	951	c.529T>C	c.(529-531)Tgg>Cgg	p.W177R		NM_002163.2	NP_002154.1	Q02556	IRF8_HUMAN	interferon regulatory factor 8	177					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	nucleus	DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	24		Prostate(104;0.0771)				CCTTCCAGACTGGTGGGCGCA	0.622000													39	65					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155176718	155176718	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:155176718C>T	ENST00000357232.4	-	21	5528	c.5529G>A	c.(5527-5529)gtG>gtA	p.V1843V		NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2		Cadherin 16.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TTGTTGTTATCACACCACTCA	0.463000													11	43					0	0	1	0	0
RABGGTA	5875	broad.mit.edu	37	14	24738856	24738856	+	Translation_Start_Site	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr14:24738856C>T	ENST00000560777.1	-	0	93				RABGGTA_ENST00000559586.1_5'UTR|RABGGTA_ENST00000399409.3_Missense_Mutation_p.V158M|RABGGTA_ENST00000216840.6_Missense_Mutation_p.V158M			Q92696	PGTA_HUMAN	Rab geranylgeranyltransferase, alpha subunit						visual perception		Rab geranylgeranyltransferase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)	12				GBM - Glioblastoma multiforme(265;0.0184)		GCAGGGGGCACGGCTGCCTGT	0.582000													5	41					0	0	1	0	0
BARHL2	343472	broad.mit.edu	37	1	91182553	91182553	+	Nonsense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:91182553G>C	ENST00000370445.4	-	1	241	c.200C>G	c.(199-201)tCa>tGa	p.S67*		NM_020063.1	NP_064447.1	Q9NY43	BARH2_HUMAN	BarH-like homeobox 2	67						nucleus	sequence-specific DNA binding			cervix(2)|endometrium(1)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24		all_lung(203;0.0263)|Lung SC(238;0.128)		all cancers(265;0.000897)|Epithelial(280;0.00516)|OV - Ovarian serous cystadenocarcinoma(397;0.211)		CATGGTGACTGAGATAGGAGA	0.662000													43	32					0	0	1	0	0
NECAB1	64168	broad.mit.edu	37	8	91893321	91893321	+	Missense_Mutation	SNP	A	A	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr8:91893321A>G	ENST00000417640.2	+	5	657	c.320A>G	c.(319-321)aAt>aGt	p.N107S	NECAB1_ENST00000521954.1_3'UTR	NM_022351.4	NP_071746.1	Q8N987	NECA1_HUMAN	N-terminal EF-hand calcium binding protein 1	107					antibiotic biosynthetic process	cytoplasm	calcium ion binding|oxidoreductase activity			breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(7)	12			BRCA - Breast invasive adenocarcinoma(11;0.0499)			GAAGACCTGAATCTTTCCATC	0.294000													3	33					0	0	1	0	0
PSMC5	5705	broad.mit.edu	37	17	61908478	61908478	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:61908478C>T	ENST00000310144.6	+	8	1070	c.762C>T	c.(760-762)atC>atT	p.I254I	PSMC5_ENST00000580864.1_Silent_p.I246I|PSMC5_ENST00000581882.1_Silent_p.I246I|PSMC5_ENST00000375812.4_Silent_p.I246I	NM_002805.5	NP_002796.4	P62195	PRS8_HUMAN	proteasome (prosome, macropain) 26S subunit, ATPase, 5	254					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of programmed cell death|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|transcription from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|ATPase activity|thyrotropin-releasing hormone receptor binding|transcription cofactor activity|transcription factor binding			endometrium(3)|kidney(2)|large_intestine(8)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	20						TCGACTCCATCGGCTCCTCGC	0.587000													48	78					0	0	1	0	0
UBA6	55236	broad.mit.edu	37	4	68536256	68536256	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:68536256C>T	ENST00000322244.5	-	8	660	c.601G>A	c.(601-603)Gat>Aat	p.D201N	UBA6_ENST00000420827.2_Missense_Mutation_p.D201N	NM_018227.5	NP_060697.4	A0AVT1	UBA6_HUMAN	ubiquitin-like modifier activating enzyme 6						protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding			central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(6)|liver(1)|lung(23)|skin(2)|upper_aerodigestive_tract(2)	44						TCAAATTCATCACCGAAATCA	0.264000													22	71					0	0	1	0	0
UBE2S	27338	broad.mit.edu	37	19	55918225	55918225	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:55918225C>T	ENST00000264552.9	-	2	296	c.109G>A	c.(109-111)Gag>Aag	p.E37K	UBE2S_ENST00000589978.1_Missense_Mutation_p.E37K	NM_014501.2	NP_055316.2	Q16763	UBE2S_HUMAN	ubiquitin-conjugating enzyme E2S	37					activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|exit from mitosis|free ubiquitin chain polymerization|protein K11-linked ubiquitination|protein K27-linked ubiquitination|protein K29-linked ubiquitination|protein K6-linked ubiquitination|protein K63-linked ubiquitination	anaphase-promoting complex	ATP binding|ubiquitin-protein ligase activity			lung(1)	1	Breast(117;0.155)		LUSC - Lung squamous cell carcinoma(43;0.13)|BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.11)		AGGTCCTCCTCGTTGGGAAAG	0.587000													55	37					0	0	1	0	0
DSC3	1825	broad.mit.edu	37	18	28581610	28581610	+	Missense_Mutation	SNP	T	T	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr18:28581610T>A	ENST00000434452.1	-	14	2363	c.2209A>T	c.(2209-2211)Aca>Tca	p.T737S	DSC3_ENST00000360428.4_Missense_Mutation_p.T737S	NM_024423.2	NP_077741.2	Q14574	DSC3_HUMAN	desmocollin 3	737					homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(29)|ovary(2)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56			OV - Ovarian serous cystadenocarcinoma(10;0.125)			GGTGCTTCTGTGTTTGATATA	0.313000													29	73					0	0	1	0	0
KIAA2026	158358	broad.mit.edu	37	9	5920223	5920223	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr9:5920223G>C	ENST00000399933.3	-	8	5772	c.5773C>G	c.(5773-5775)Ctt>Gtt	p.L1925V	KIAA2026_ENST00000381461.2_Missense_Mutation_p.L1895V	NM_001017969.2	NP_001017969.2	Q5HYC2	K2026_HUMAN	KIAA2026	1925										breast(6)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(1)	46		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		CCACTGTTAAGAACTAAGGGG	0.433000													39	70					0	0	1	0	0
ABCA3	21	broad.mit.edu	37	16	2374431	2374431	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr16:2374431G>A	ENST00000301732.5	-	6	1121	c.421C>T	c.(421-423)Cac>Tac	p.H141Y	ABCA3_ENST00000382381.3_Missense_Mutation_p.H141Y|ABCA3_ENST00000567910.1_Missense_Mutation_p.H141Y	NM_001089.2	NP_001080.2	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 3	141					response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(7)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(7)|prostate(5)|skin(6)|upper_aerodigestive_tract(1)	70		Ovarian(90;0.17)				TCCTTGCTGTGGTTGAAGGGG	0.642000													4	8					0	0	1	0	0
RNF157	114804	broad.mit.edu	37	17	74161588	74161588	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:74161588C>G	ENST00000269391.6	-	7	799	c.667G>C	c.(667-669)Gag>Cag	p.E223Q	RNF157_ENST00000319945.6_Missense_Mutation_p.E223Q	NM_052916.2	NP_443148.1	Q96PX1	RN157_HUMAN	ring finger protein 157	223							zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(3)|lung(12)|ovary(2)|prostate(1)|skin(1)|stomach(2)|urinary_tract(1)	25			LUSC - Lung squamous cell carcinoma(166;0.187)			CTCACCTTCTCAAAAGTACCC	0.483000													15	173					0	0	1	0	0
SNX17	9784	broad.mit.edu	37	2	27597298	27597298	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:27597298G>C	ENST00000233575.2	+	7	831	c.609G>C	c.(607-609)aaG>aaC	p.K203N	SNX17_ENST00000542478.1_5'UTR|SNX17_ENST00000537606.1_Missense_Mutation_p.K178N|SNX17_ENST00000543024.1_5'UTR	NM_001267059.1|NM_001267061.1|NM_014748.3	NP_001253988.1|NP_001253990.1|NP_055563.1	Q15036	SNX17_HUMAN	sorting nexin 17	203	Ras-associating.				cell communication|endosome transport|intracellular protein transport|regulation of endocytosis|signal transduction	cytoplasmic vesicle membrane|cytosol|early endosome|Golgi apparatus	low-density lipoprotein particle receptor binding|phosphatidylinositol binding|protein C-terminus binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(4)|ovary(1)	14	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGCTAAGGAAGAGGTCAGGGC	0.493000													5	47					0	0	1	0	0
KLK7	5650	broad.mit.edu	37	19	51483506	51483506	+	Silent	SNP	C	C	T	rs141002495		TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:51483506C>T	ENST00000391807.1	-	4	560	c.459G>A	c.(457-459)acG>acA	p.T153T	CTB-147C22.9_ENST00000594512.1_RNA|KLK7_ENST00000597707.1_Silent_p.T81T|KLK7_ENST00000595820.1_Silent_p.T153T|KLK7_ENST00000336317.4_Silent_p.T40T	NM_139277.2	NP_644806.1	P49862	KLK7_HUMAN	kallikrein-related peptidase 7	153	Peptidase S1.				epidermis development|proteolysis	extracellular region	serine-type endopeptidase activity			NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(11)|ovary(2)	19		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00382)|GBM - Glioblastoma multiforme(134;0.00895)		CATCTGGGCTCGTGGTAGTGC	0.667000													15	24					0	0	1	0	0
CHD6	84181	broad.mit.edu	37	20	40161851	40161851	+	Missense_Mutation	SNP	C	C	G	rs75576471	by1000genomes	TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr20:40161851C>G	ENST00000373233.3	-	3	569	c.392G>C	c.(391-393)aGa>aCa	p.R131T	CHD6_ENST00000309279.7_Missense_Mutation_p.R131T|CHD6_ENST00000373222.3_Missense_Mutation_p.R166T	NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	131	Lys-rich.				chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				CTTGGCCTTTCTGGGTTCCTT	0.572000													5	784					0	0	1	0	0
ZCCHC5	203430	broad.mit.edu	37	X	77912675	77912675	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chrX:77912675G>A	ENST00000321110.1	-	2	1538	c.1243C>T	c.(1243-1245)Cca>Tca	p.P415S		NM_152694.2	NP_689907.1	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	415							nucleic acid binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(1)|prostate(1)|skin(1)	37						TCAGCTGGTGGACTCTCGGGT	0.522000													5	70					0	0	1	0	0
XG	7499	broad.mit.edu	37	X	2670374	2670374	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chrX:2670374G>A	ENST00000426774.1	+	1	282	c.59G>A	c.(58-60)cGa>cAa	p.R20Q	XG_ENST00000381174.5_Missense_Mutation_p.R20Q|XG_ENST00000419513.2_Missense_Mutation_p.R20Q	NM_001141920.1|NM_175569.2	NP_001135392.1|NP_780778.1	P55808	XG_HUMAN	Xg blood group	20						integral to membrane|plasma membrane				endometrium(1)|large_intestine(3)|lung(3)|ovary(1)	8		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				ATGCACGCCCGAGGTAAGAGG	0.483000													6	159					0	0	1	0	0
DCAF8L1	139425	broad.mit.edu	37	X	27999090	27999090	+	Missense_Mutation	SNP	G	G	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chrX:27999090G>T	ENST00000441525.1	-	1	476	c.362C>A	c.(361-363)cCa>cAa	p.P121Q		NM_001017930.1	NP_001017930.1	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	121										NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(24)|ovary(3)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	56						ACCGCATCGTGGACACATCCG	0.542000													36	1					1.836e-18	1.96488e-18	1	1	0
CLEC7A	64581	broad.mit.edu	37	12	10280346	10280346	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:10280346C>G	ENST00000525605.1	-	3	271	c.202G>C	c.(202-204)Ggt>Cgt	p.G68R	CLEC7A_ENST00000310002.4_Splice_Site_p.A68P|CLEC7A_ENST00000353231.5_Splice_Site_p.G68R|CLEC7A_ENST00000298523.5_Splice_Site_p.G68R|CLEC7A_ENST00000304084.8_Splice_Site_p.A68P|CLEC7A_ENST00000533022.1_Splice_Site_p.A68P|CLEC7A_ENST00000396484.2_Intron			Q9BXN2	CLC7A_HUMAN	C-type lectin domain family 7, member A	0					carbohydrate mediated signaling|defense response to protozoan|inflammatory response|innate immune response|phagocytosis, recognition|T cell activation	cytoplasm|integral to membrane	metal ion binding|MHC protein binding|sugar binding			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(1)|upper_aerodigestive_tract(1)	7						AAATACTCACCCATGGTACCC	0.433000													3	8					0	0	1	0	0
BAZ2A	11176	broad.mit.edu	37	12	57007800	57007800	+	Nonsense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:57007800G>A	ENST00000179765.5	-	5	962	c.763C>T	c.(763-765)Caa>Taa	p.Q255*	BAZ2A_ENST00000379441.3_Nonsense_Mutation_p.Q257*|BAZ2A_ENST00000549884.1_Nonsense_Mutation_p.Q285*|BAZ2A_ENST00000551812.1_Nonsense_Mutation_p.Q287*			Q9UIF9	BAZ2A_HUMAN	bromodomain adjacent to zinc finger domain, 2A	287					chromatin silencing at rDNA|DNA methylation|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	DNA binding|histone acetyl-lysine binding|ligand-dependent nuclear receptor binding|RNA binding|zinc ion binding			breast(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(15)|urinary_tract(1)	31						TCTTCCAGTTGATCAGGAAGA	0.502000													32	26					0	0	1	0	0
SGIP1	84251	broad.mit.edu	37	1	67145429	67145429	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:67145429G>C	ENST00000371037.4	+	14	885	c.808G>C	c.(808-810)Gga>Cga	p.G270R	SGIP1_ENST00000237247.6_Missense_Mutation_p.G274R|SGIP1_ENST00000371039.1_Missense_Mutation_p.G238R|SGIP1_ENST00000371035.3_Missense_Mutation_p.G227R|SGIP1_ENST00000371036.3_Missense_Mutation_p.G237R	NM_032291.2	NP_115667.2	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting protein 1	270	Pro-rich.				positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(43)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	71						CTTAACAATTGGACCAGGTAC	0.468000													28	57					0	0	1	0	0
PSIP1	11168	broad.mit.edu	37	9	15489994	15489994	+	Nonsense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr9:15489994G>C	ENST00000380733.4	-	4	621	c.278C>G	c.(277-279)tCa>tGa	p.S93*	PSIP1_ENST00000380715.1_Nonsense_Mutation_p.S93*|PSIP1_ENST00000380738.4_Nonsense_Mutation_p.S93*|PSIP1_ENST00000397519.2_Nonsense_Mutation_p.S93*|PSIP1_ENST00000380716.4_Nonsense_Mutation_p.S93*			O75475	PSIP1_HUMAN	PC4 and SFRS1 interacting protein 1	93					initiation of viral infection|interspecies interaction between organisms|nuclear mRNA 5'-splice site recognition|provirus integration|regulation of transcription, DNA-dependent|response to heat|response to oxidative stress|transcription, DNA-dependent	cytosol|nuclear heterochromatin|nuclear periphery|nucleoplasm|transcriptionally active chromatin	activating transcription factor binding|chromatin binding|DNA secondary structure binding|RNA polymerase II transcription coactivator activity			breast(2)|endometrium(2)|kidney(1)|lung(3)|prostate(1)	9				GBM - Glioblastoma multiforme(50;2.38e-06)		CTGTTGACTTGAAAATTTCAC	0.299000													10	1					0	0	1	0	0
TEKT1	83659	broad.mit.edu	37	17	6722592	6722592	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:6722592G>A	ENST00000338694.2	-	3	405	c.276C>T	c.(274-276)ctC>ctT	p.L92L	TEKT1_ENST00000535086.1_Intron	NM_053285.1	NP_444515.1	Q969V4	TEKT1_HUMAN	tektin 1	92					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)|stomach(1)	20		Myeloproliferative disorder(207;0.0255)				TCTTATATATGAGTAGATCAT	0.473000													40	7					0	0	1	0	0
HCCS	3052	broad.mit.edu	37	X	11135429	11135429	+	Missense_Mutation	SNP	G	G	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chrX:11135429G>T	ENST00000321143.4	+	4	497	c.295G>T	c.(295-297)Gca>Tca	p.A99S	HCCS_ENST00000380762.4_Missense_Mutation_p.A99S|HCCS_ENST00000380763.3_Missense_Mutation_p.A99S	NM_001122608.2|NM_001171991.2|NM_005333.4	NP_001116080.1|NP_001165462.1|NP_005324.3	P53701	CCHL_HUMAN	holocytochrome c synthase	99					organ morphogenesis|oxidation-reduction process	mitochondrial inner membrane	holocytochrome-c synthase activity|metal ion binding			kidney(1)|large_intestine(3)|lung(3)	7						TCAGCCATTTGCATTGTCTAC	0.373000													55	70					1.93748e-29	2.10252e-29	1	1	0
TRIM11	81559	broad.mit.edu	37	1	228594194	228594194	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:228594194G>A	ENST00000284551.6	-	1	347	c.69C>T	c.(67-69)ttC>ttT	p.F23F	TRIM11_ENST00000366699.3_Silent_p.F23F	NM_145214.2	NP_660215.1	Q96F44	TRI11_HUMAN	tripartite motif containing 11	23					response to virus	cytoplasm|nucleus	protein binding|zinc ion binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|skin(1)	18		Prostate(94;0.0724)				CCGGATCCGTGAAGTAGTCGA	0.697000													14	24					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144859897	144859897	+	Nonsense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:144859897G>A	ENST00000369359.4	-	41	6633	c.6595C>T	c.(6595-6597)Cag>Tag	p.Q2199*	PDE4DIP_ENST00000524974.1_5'UTR|PDE4DIP_ENST00000530740.1_Nonsense_Mutation_p.Q2148*|PDE4DIP_ENST00000369354.3_Nonsense_Mutation_p.Q2063*|PDE4DIP_ENST00000313382.9_Nonsense_Mutation_p.Q1957*|PDE4DIP_ENST00000369356.4_Nonsense_Mutation_p.Q2063*|RP4-791M13.4_ENST00000532137.1_RNA			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	2063					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TTGTTCCCCTGAATGCTCTGC	0.582000			T	PDGFRB	MPD								36	100					0	0	1	0	0
PFDN6	10471	broad.mit.edu	37	6	33258577	33258577	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:33258577C>G	ENST00000395131.1	+	5	751	c.345C>G	c.(343-345)ttC>ttG	p.F115L	PFDN6_ENST00000374610.2_Missense_Mutation_p.F115L|PFDN6_ENST00000374607.1_Missense_Mutation_p.F115L|PFDN6_ENST00000463584.1_Intron|PFDN6_ENST00000374606.5_Missense_Mutation_p.F115L			O15212	PFD6_HUMAN	prefoldin subunit 6	115					'de novo' posttranslational protein folding|chaperone-mediated protein complex assembly	prefoldin complex	chaperone binding|unfolded protein binding			kidney(1)|large_intestine(1)	2						AGCAGGAGTTCCAGCGGGCCC	0.622000													8	22					0	0	1	0	0
JSRP1	126306	broad.mit.edu	37	19	2252961	2252961	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:2252961C>G	ENST00000300961.6	-	6	542	c.478G>C	c.(478-480)Gag>Cag	p.E160Q	JSRP1_ENST00000586471.2_Missense_Mutation_p.E160Q	NM_144616.3	NP_653217.1	Q96MG2	JSPR1_HUMAN	junctional sarcoplasmic reticulum protein 1		Pro-rich.					sarcoplasmic reticulum membrane				haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|pancreas(1)|urinary_tract(1)	6				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCCAGGGCTCGGGCACACGT	0.682000													12	10					0	0	1	0	0
MZF1	7593	broad.mit.edu	37	19	59074422	59074422	+	Nonsense_Mutation	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:59074422C>A	ENST00000215057.2	-	6	1782	c.1222G>T	c.(1222-1224)Gag>Tag	p.E408*	AC016629.8_ENST00000593642.1_RNA|MZF1_ENST00000594234.1_3'UTR|AC016629.8_ENST00000600534.1_RNA|MZF1_ENST00000599369.1_Nonsense_Mutation_p.E408*|AC016629.8_ENST00000600726.1_RNA	NM_001267033.1|NM_198055.1	NP_001253962.1|NP_932172.1	P28698	MZF1_HUMAN	myeloid zinc finger 1	408					viral reproduction	nucleus	protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0443)|all cancers(4;7.92e-14)|Epithelial(4;5.57e-11)|OV - Ovarian serous cystadenocarcinoma(4;1.13e-09)|GBM - Glioblastoma multiforme(193;0.0108)|Lung(386;0.182)		GGCCGCTCCTCGGTGTGCGTA	0.677000													17	7					5.3912e-06	5.5524e-06	1	1	0
ZFHX3	463	broad.mit.edu	37	16	72992974	72992974	+	Silent	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr16:72992974G>C	ENST00000268489.5	-	2	1743	c.1071C>G	c.(1069-1071)ctC>ctG	p.L357L	ZFHX3_ENST00000397992.5_Intron	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	357					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				CGGGGCCTATGAGGTTAGCTG	0.507000													46	64					0	0	1	0	0
OR8K5	219453	broad.mit.edu	37	11	55927735	55927735	+	Missense_Mutation	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:55927735C>A	ENST00000313447.1	-	1	58	c.59G>T	c.(58-60)cGg>cTg	p.R20L		NM_001004058.2	NP_001004058.2	Q8NH50	OR8K5_HUMAN	olfactory receptor, family 8, subfamily K, member 5	20					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R20P(1)		large_intestine(3)|lung(24)|ovary(2)|pancreas(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	34	Esophageal squamous(21;0.00693)	Lung NSC(402;0.197)|all_epithelial(135;0.236)				CAGCTCAGGCCGCCTTGTGAG	0.443000													60	82					1.84395e-34	2.01513e-34	1	1	0
ZBTB22	9278	broad.mit.edu	37	6	33284441	33284441	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:33284441G>C	ENST00000431845.2	-	2	404	c.253C>G	c.(253-255)Cag>Gag	p.Q85E	ZBTB22_ENST00000418724.1_Missense_Mutation_p.Q85E	NM_005453.4	NP_005444.4	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	85	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(9)|ovary(2)|prostate(1)|urinary_tract(3)	21						AGTAGGACCTGATCATGGAAG	0.607000													28	113					0	0	1	0	0
C22orf29	79680	broad.mit.edu	37	22	19839434	19839434	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr22:19839434G>A	ENST00000405640.1	-	2	1019	c.351C>T	c.(349-351)ttC>ttT	p.F117F	C22orf29_ENST00000407472.1_Silent_p.F117F|C22orf29_ENST00000484072.1_Intron|C22orf29_ENST00000328554.4_Silent_p.F117F|GNB1L_ENST00000403325.1_Intron|GNB1L_ENST00000329517.6_Intron|GNB1L_ENST00000405009.1_Intron|GNB1L_ENST00000460402.1_Intron			Q7L3V2	CV029_HUMAN	chromosome 22 open reading frame 29	117										NS(1)|large_intestine(1)|lung(3)|prostate(1)|urinary_tract(1)	7	Colorectal(54;0.0993)					GCTGGGCCAAGAAGCGGTCCA	0.617000													36	66					0	0	1	0	0
TP53INP1	94241	broad.mit.edu	37	8	95952410	95952410	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr8:95952410C>G	ENST00000342697.4	-	3	558	c.151G>C	c.(151-153)Gag>Cag	p.E51Q	TP53INP1_ENST00000448464.2_Missense_Mutation_p.E51Q|TP53INP1_ENST00000378776.4_Missense_Mutation_p.E51Q|NDUFAF6_ENST00000396113.1_Intron	NM_033285.3	NP_150601.1	Q96A56	T53I1_HUMAN	tumor protein p53 inducible nuclear protein 1	51	Glu-rich.				apoptosis	PML body				kidney(2)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	9	Breast(36;8.75e-07)					ATGTCCTCCTCTTCTTCTTCT	0.463000													51	40					0	0	1	0	0
NPY1R	4886	broad.mit.edu	37	4	164246739	164246739	+	Nonsense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:164246739G>A	ENST00000296533.2	-	3	1402	c.871C>T	c.(871-873)Cag>Tag	p.Q291*	NPY1R_ENST00000509586.1_Nonsense_Mutation_p.Q48*	NM_000909.5	NP_000900.1	P25929	NPY1R_HUMAN	neuropeptide Y receptor Y1	291					inhibition of adenylate cyclase activity by G-protein signaling pathway|outflow tract morphogenesis	integral to plasma membrane	protein binding			breast(1)|cervix(1)|large_intestine(4)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)	30	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				GCAATGATCTGATGATTCCAA	0.428000													17	54					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57573702	57573702	+	Missense_Mutation	SNP	G	G	C	rs141183147		TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:57573702G>C	ENST00000243077.3	+	30	5570	c.5104G>C	c.(5104-5106)Gag>Cag	p.E1702Q		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	1702					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GCAGGGCCTGGAGCAGCCCCA	0.617000													31	99					0	0	1	0	0
TACR3	6870	broad.mit.edu	37	4	104511087	104511087	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:104511087C>T	ENST00000304883.2	-	5	1290	c.1150G>A	c.(1150-1152)Gag>Aag	p.E384K	RP11-297P16.3_ENST00000512401.1_RNA|RP11-297P16.3_ENST00000502936.1_RNA	NM_001059.2	NP_001050.1	P29371	NK3R_HUMAN	tachykinin receptor 3	384						integral to plasma membrane	tachykinin receptor activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		AGCTCTAGCTCATCATAGCTG	0.468000													53	63					0	0	1	0	0
LTB	4050	broad.mit.edu	37	6	31550142	31550142	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:31550142G>A	ENST00000429299.2	-	1	60	c.53C>T	c.(52-54)tCc>tTc	p.S18F	LTB_ENST00000483972.1_Intron|LTB_ENST00000446745.2_Missense_Mutation_p.S18F	NM_002341.1	NP_002332.1	Q06643	TNFC_HUMAN	lymphotoxin beta (TNF superfamily, member 3)	18					cell-cell signaling|immune response|positive regulation of interleukin-12 biosynthetic process|signal transduction	extracellular space|integral to membrane	cytokine activity|tumor necrosis factor receptor binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(2)|prostate(1)|upper_aerodigestive_tract(1)	9					Infliximab(DB00065)|Simvastatin(DB00641)	TAGCAGGAGGGAACCCCTCCC	0.637000													14	37					0	0	1	0	0
CLVS2	134829	broad.mit.edu	37	6	123319061	123319061	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:123319061C>G	ENST00000275162.5	+	2	1474	c.139C>G	c.(139-141)Ctg>Gtg	p.L47V	CLVS2_ENST00000368438.1_Intron	NM_001010852.3	NP_001010852.2	Q5SYC1	CLVS2_HUMAN	clavesin 2						lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	40						CATTGGCTTTCTGCGCACGGA	0.557000													48	39					0	0	1	0	0
LILRA5	353514	broad.mit.edu	37	19	54822982	54822982	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:54822982G>C	ENST00000301219.3	-	5	533	c.414C>G	c.(412-414)ttC>ttG	p.F138L	LILRA5_ENST00000446712.3_Missense_Mutation_p.F126L|AC008984.2_ENST00000507363.1_RNA|LILRA5_ENST00000432233.3_Missense_Mutation_p.F138L|LILRA5_ENST00000346508.3_Missense_Mutation_p.F126L	NM_021250.2	NP_067073.1	A6NI73	LIRA5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5	138					innate immune response	extracellular region|integral to membrane	receptor activity			breast(1)|endometrium(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	20	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GTTTGTTGTAGAATCCTAGGA	0.592000													53	46					0	0	1	0	0
RLF	6018	broad.mit.edu	37	1	40703673	40703673	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:40703673C>T	ENST00000372771.4	+	8	3326	c.3299C>T	c.(3298-3300)tCa>tTa	p.S1100L		NM_012421.3	NP_036553.2	Q13129	RLF_HUMAN	rearranged L-myc fusion	1100					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(18)|lung(18)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(4)|urinary_tract(2)	68	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			CAGTCAGTTTCATCTATCTCA	0.418000													137	63					0	0	1	0	0
ANKRD30BP2	149992	broad.mit.edu	37	21	14414855	14414855	+	RNA	SNP	A	A	G	rs141732548	by1000genomes	TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr21:14414855A>G	ENST00000507941.1	+	0	95																											GCCAATGGCCATGCAGAAGTA	0.448000													4	57					0	0	1	0	0
RUFY1	80230	broad.mit.edu	37	5	178996330	178996330	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:178996330G>A	ENST00000377001.2	+	5	732	c.732G>A	c.(730-732)atG>atA	p.M244I	RUFY1_ENST00000319449.4_Missense_Mutation_p.M244I|RUFY1_ENST00000393438.2_Missense_Mutation_p.M136I|RUFY1_ENST00000437570.2_Missense_Mutation_p.M136I			Q96T51	RUFY1_HUMAN	RUN and FYVE domain containing 1	244	RUN.				endocytosis|protein transport	early endosome membrane	lipid binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(11)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	26	all_cancers(89;0.00018)|all_epithelial(37;8.37e-05)|Renal(175;0.000159)|Lung NSC(126;0.00108)|all_lung(126;0.00195)	all_cancers(40;0.0322)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGGCTTTAATGATGGAGGAAG	0.502000										HNSCC(44;0.11)			5	145					0	0	1	0	0
NID2	22795	broad.mit.edu	37	14	52526909	52526909	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr14:52526909C>T	ENST00000216286.5	-	3	699	c.700G>A	c.(700-702)Gat>Aat	p.D234N	NID2_ENST00000541773.1_Missense_Mutation_p.D181N	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	234	NIDO.					basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					GACTTCAGATCATCAGCCTCC	0.498000													27	6					0	0	1	0	0
EPO	2056	broad.mit.edu	37	7	100320699	100320699	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:100320699C>T	ENST00000252723.2	+	5	706	c.525C>T	c.(523-525)ttC>ttT	p.F175F		NM_000799.2	NP_000790.2	P01588	EPO_HUMAN	erythropoietin	175					blood circulation|cellular hyperosmotic response|erythrocyte maturation|negative regulation of apoptosis|negative regulation of ion transmembrane transporter activity|negative regulation of sodium ion transport|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of Ras protein signal transduction|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat5 protein|signal transduction	extracellular space	erythropoietin receptor binding|eukaryotic cell surface binding|hormone activity			central_nervous_system(2)|endometrium(2)|lung(7)|prostate(1)	12	Lung NSC(181;0.041)|all_lung(186;0.0581)				Darbepoetin alfa(DB00012)|Epoetin alfa(DB00016)	ACTCCAATTTCCTCCGGGGAA	0.572000													94	191					0	0	1	0	0
KIAA1551	55196	broad.mit.edu	37	12	32135112	32135112	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:32135112C>T	ENST00000312561.4	+	4	1637	c.1223C>T	c.(1222-1224)tCa>tTa	p.S408L	KIAA1551_ENST00000535596.1_Intron	NM_018169.3	NP_060639			KIAA1551																		CAGAAGTTTTCAGAACTTGCA	0.318000													8	154					0	0	1	0	0
RBKS	64080	broad.mit.edu	37	2	28081412	28081412	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:28081412C>T	ENST00000302188.3	-	2	868	c.116G>A	c.(115-117)gGa>gAa	p.G39E	RBKS_ENST00000444339.2_Missense_Mutation_p.G39E	NM_022128.1	NP_071411.1	Q9H477	RBSK_HUMAN	ribokinase	39					D-ribose metabolic process		ATP binding|ribokinase activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	7	Acute lymphoblastic leukemia(172;0.155)					GATGGTTTCTCCAGTTTTTGG	0.398000													18	21					0	0	1	0	0
RHOU	58480	broad.mit.edu	37	1	228879189	228879189	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:228879189G>C	ENST00000366691.3	+	3	1145	c.479G>C	c.(478-480)gGa>gCa	p.G160A		NM_021205.5	NP_067028.1	Q7L0Q8	RHOU_HUMAN	ras homolog family member U	160					regulation of small GTPase mediated signal transduction	cell projection|cytosol|focal adhesion|Golgi membrane|podosome	GTP binding|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)|stomach(1)	13	Breast(184;0.162)	Prostate(94;0.183)				ATCCTAGTTGGAACGCAGTCG	0.532000													8	157					0	0	1	0	0
C14orf159	80017	broad.mit.edu	37	14	91666179	91666179	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr14:91666179C>G	ENST00000518868.1	+	14	2064	c.1374C>G	c.(1372-1374)atC>atG	p.I458M	C14orf159_ENST00000522322.1_Missense_Mutation_p.I453M|C14orf159_ENST00000523816.1_Missense_Mutation_p.I453M|C14orf159_ENST00000523771.1_Missense_Mutation_p.I453M|C14orf159_ENST00000412671.2_Missense_Mutation_p.I458M|C14orf159_ENST00000256324.10_Missense_Mutation_p.I458M|C14orf159_ENST00000525393.2_Missense_Mutation_p.I329M|C14orf159_ENST00000521077.2_Missense_Mutation_p.I458M|C14orf159_ENST00000428926.2_Missense_Mutation_p.I453M|C14orf159_ENST00000520328.1_Missense_Mutation_p.I441M			Q7Z3D6	CN159_HUMAN	chromosome 14 open reading frame 159	453						mitochondrion				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	21		all_cancers(154;0.0191)|all_epithelial(191;0.241)		Epithelial(152;0.141)|OV - Ovarian serous cystadenocarcinoma(161;0.207)		AGATGAACATCAAGCACTTGG	0.488000													8	90					0	0	1	0	0
AKAP11	11215	broad.mit.edu	37	13	42877892	42877892	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr13:42877892C>T	ENST00000025301.2	+	8	5185	c.5010C>T	c.(5008-5010)agC>agT	p.S1670S		NM_016248.3	NP_057332.1	Q9UKA4	AKA11_HUMAN	A kinase (PRKA) anchor protein 11	1670					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|skin(3)|stomach(2)	56		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		GCAGTACCAGCCTGGCAGCCG	0.512000													29	19					0	0	1	0	0
DROSHA	29102	broad.mit.edu	37	5	31526614	31526614	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:31526614G>A	ENST00000511367.2	-	4	670	c.426C>T	c.(424-426)ttC>ttT	p.F142F	DROSHA_ENST00000442743.1_Silent_p.F142F|DROSHA_ENST00000344624.3_Silent_p.F142F|DROSHA_ENST00000513349.1_Silent_p.F142F	NM_013235.4	NP_037367.3	Q9NRR4	RNC_HUMAN	drosha, ribonuclease type III	142	Pro-rich.				gene silencing by RNA|ribosome biogenesis|RNA processing	nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(19)|lung(33)|ovary(2)|skin(1)	66						TCATGAAGGGGAAAGTGCCTT	0.587000													11	37					0	0	1	0	0
MYRF	745	broad.mit.edu	37	11	61539167	61539167	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:61539167C>T	ENST00000278836.5	+	6	1032	c.936C>T	c.(934-936)ctC>ctT	p.L312L	MYRF_ENST00000265460.5_Silent_p.L303L|TMEM258_ENST00000535042.1_Intron	NM_001127392.1	NP_001120864.1			myelin regulatory factor																		CCTTGCCTCTCAGCATTGCCC	0.692000													103	94					0	0	1	0	0
DNMT1	1786	broad.mit.edu	37	19	10260222	10260222	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:10260222G>C	ENST00000340748.4	-	25	2680	c.2445C>G	c.(2443-2445)ttC>ttG	p.F815L	DNMT1_ENST00000540357.1_Missense_Mutation_p.F815L|DNMT1_ENST00000359526.4_Missense_Mutation_p.F831L			P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1	815	BAH 1.				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			breast(5)|endometrium(8)|kidney(5)|large_intestine(21)|lung(11)|ovary(2)|pancreas(1)|prostate(10)|skin(5)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	CATCCACCAAGAACAGCTCCA	0.557000													44	735					0	0	1	0	0
CHD5	26038	broad.mit.edu	37	1	6184104	6184104	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:6184104C>T	ENST00000262450.3	-	31	4702	c.4603G>A	c.(4603-4605)Gag>Aag	p.E1535K	CHD5_ENST00000378021.1_Missense_Mutation_p.E392K	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1535					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		TTCTTCCCCTCGGGCCCCTCA	0.652000													15	29					0	0	1	0	0
SEMA3E	9723	broad.mit.edu	37	7	82996925	82996925	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:82996925G>A	ENST00000307792.3	-	17	2772	c.2305C>T	c.(2305-2307)Ccc>Tcc	p.P769S	SEMA3E_ENST00000427262.1_Missense_Mutation_p.P709S	NM_012431.2	NP_036563.1	O15041	SEM3E_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	769	Arg/Lys-rich (basic).				axon guidance	extracellular space|membrane	receptor activity			breast(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(19)|ovary(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	51		Medulloblastoma(109;0.109)				GTGTGCCTGGGCAGGCGGTAA	0.413000													98	98					0	0	1	0	0
FABP12	646486	broad.mit.edu	37	8	82437306	82437306	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr8:82437306G>A	ENST00000360464.4	-	4	460	c.398C>T	c.(397-399)tCa>tTa	p.S133L	RP11-257P3.3_ENST00000523380.1_RNA|RP11-257P3.3_ENST00000518637.1_RNA	NM_001105281.1	NP_001098751.1	A6NFH5	FBP12_HUMAN	fatty acid binding protein 12	133							lipid binding|transporter activity	p.S133*(1)		large_intestine(1)|lung(3)	4						TGAGTTTGATGATACTTTCTC	0.323000													5	17					0	0	1	0	0
EPHA3	2042	broad.mit.edu	37	3	89391064	89391064	+	Missense_Mutation	SNP	G	G	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:89391064G>T	ENST00000336596.2	+	5	1355	c.1130G>T	c.(1129-1131)aGc>aTc	p.S377I	EPHA3_ENST00000494014.1_Missense_Mutation_p.S377I|EPHA3_ENST00000452448.2_Missense_Mutation_p.S377I	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	377	Fibronectin type-III 1.					extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		GAGCCATGCAGCCCAAATGTC	0.483000										TSP Lung(6;0.00050)			11	78					4.3838e-07	4.55523e-07	1	1	0
PARP9	83666	broad.mit.edu	37	3	122274520	122274520	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:122274520C>G	ENST00000462315.1	-	4	791	c.498G>C	c.(496-498)tgG>tgC	p.W166C	PARP9_ENST00000477522.2_Missense_Mutation_p.W166C|PARP9_ENST00000492382.1_Intron|PARP9_ENST00000471785.1_Missense_Mutation_p.W166C|PARP9_ENST00000360356.2_Missense_Mutation_p.W201C	NM_001146106.1	NP_001139578.1	Q8IXQ6	PARP9_HUMAN	poly (ADP-ribose) polymerase family, member 9	201	Macro 1.				cell migration	cytosol|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			endometrium(3)|kidney(2)|large_intestine(9)|liver(1)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(3)	34				GBM - Glioblastoma multiforme(114;0.0519)		CCCATTCCATCCACCGAGGCC	0.458000													25	24					0	0	1	0	0
SPEF2	79925	broad.mit.edu	37	5	35692776	35692776	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:35692776G>A	ENST00000440995.2	+	12	1849	c.1849G>A	c.(1849-1851)Gat>Aat	p.D617N	CTD-2113L7.1_ENST00000510433.1_RNA|SPEF2_ENST00000356031.3_Missense_Mutation_p.D617N|SPEF2_ENST00000509059.1_Missense_Mutation_p.D617N			Q9C093	SPEF2_HUMAN	sperm flagellar 2	617					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TCAGAAAAATGATGAAGAAGA	0.383000													8	153					0	0	1	0	0
TAC3	6866	broad.mit.edu	37	12	57407417	57407417	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:57407417G>C	ENST00000458521.2	-	3	312	c.153C>G	c.(151-153)ttC>ttG	p.F51L	TAC3_ENST00000415231.1_Missense_Mutation_p.F51L|TAC3_ENST00000441881.1_Missense_Mutation_p.F51L	NM_013251.3	NP_037383.1	Q9UHF0	TKNK_HUMAN	tachykinin 3	51					female pregnancy|neuropeptide signaling pathway|tachykinin receptor signaling pathway	extracellular space|soluble fraction	receptor binding			cervix(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|skin(1)	7						AGTGGCTTTTGAAGAGTCTCT	0.572000													8	21					0	0	1	0	0
ITGA6	3655	broad.mit.edu	37	2	173339838	173339838	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:173339838G>C	ENST00000375221.2	+	8	1488	c.1285G>C	c.(1285-1287)Gat>Cat	p.D429H	ITGA6_ENST00000264106.6_Missense_Mutation_p.D429H|ITGA6_ENST00000343713.4_Missense_Mutation_p.D385H|ITGA6_ENST00000409532.1_Missense_Mutation_p.D271H|ITGA6_ENST00000409080.1_Missense_Mutation_p.D390H|ITGA6_ENST00000264107.7_Missense_Mutation_p.D390H			P23229	ITA6_HUMAN	integrin, alpha 6	429					blood coagulation|cell adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter	integrin complex	protein binding|receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	44			OV - Ovarian serous cystadenocarcinoma(117;0.0979)			TATTAATCAAGATGGCTACCC	0.373000													3	40					0	0	1	0	0
STAT3	6774	broad.mit.edu	37	17	40476996	40476996	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:40476996C>T	ENST00000264657.5	-	16	1761	c.1449G>A	c.(1447-1449)ctG>ctA	p.L483L	STAT3_ENST00000389272.3_Silent_p.L385L|STAT3_ENST00000588969.1_Silent_p.L483L|STAT3_ENST00000404395.3_Silent_p.L483L|STAT3_ENST00000585517.1_Silent_p.L483L	NM_003150.3|NM_139276.2	NP_003141.2|NP_644805.1	P40763	STAT3_HUMAN	signal transducer and activator of transcription 3 (acute-phase response factor)	483					cellular component movement|eating behavior|eye photoreceptor cell differentiation|glucose homeostasis|interleukin-6-mediated signaling pathway|interspecies interaction between organisms|JAK-STAT cascade involved in growth hormone signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein import into nucleus|response to estradiol stimulus|sexual reproduction|temperature homeostasis	cytosol|nucleus|plasma membrane	calcium ion binding|ligand-regulated transcription factor activity|protein dimerization activity|protein kinase binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		all_cancers(22;1.39e-06)|all_epithelial(22;2.95e-05)|Breast(137;0.000135)		BRCA - Breast invasive adenocarcinoma(366;0.139)		GATTGTTGGTCAGCATGTTGT	0.547000									Hyperimmunoglobulin E Recurrent Infection Syndrome				7	144					0	0	1	0	0
SLC9C2	284525	broad.mit.edu	37	1	173503793	173503793	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:173503793G>C	ENST00000367714.3	-	16	2226	c.1804C>G	c.(1804-1806)Cac>Gac	p.H602D	SLC9C2_ENST00000466087.1_5'UTR|SLC9C2_ENST00000536496.1_Intron	NM_178527.3	NP_848622.2	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member C2 (putative)	602					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity										AATACTATGTGAAATATAAAA	0.264000													3	25					0	0	1	0	0
C3AR1	719	broad.mit.edu	37	12	8212240	8212240	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:8212240G>A	ENST00000307637.4	-	2	745	c.542C>T	c.(541-543)tCa>tTa	p.S181L		NM_004054.2	NP_004045.1	Q16581	C3AR_HUMAN	complement component 3a receptor 1	181					blood circulation|chemotaxis|elevation of cytosolic calcium ion concentration|inflammatory response	integral to plasma membrane	C3a anaphylatoxin receptor activity|complement component C3a receptor activity|phosphatidylinositol phospholipase C activity			breast(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(1)	20				Kidney(36;0.0893)		ATAATCTAATGAGCTGGAGAG	0.423000													33	85					0	0	1	0	0
CDH12	1010	broad.mit.edu	37	5	21854861	21854861	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:21854861C>T	ENST00000382254.1	-	7	1651	c.565G>A	c.(565-567)Gac>Aac	p.D189N	CDH12_ENST00000521384.1_5'UTR|CDH12_ENST00000504376.2_Missense_Mutation_p.D189N|CDH12_ENST00000522262.1_Intron	NM_004061.3	NP_004052.2	P55289	CAD12_HUMAN	cadherin 12, type 2 (N-cadherin 2)	189	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(19)|lung(75)|ovary(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	120						TAGGTCGGGTCATCTGCATCT	0.403000										HNSCC(59;0.17)			56	18					0	0	1	0	0
OR6T1	219874	broad.mit.edu	37	11	123814011	123814011	+	Missense_Mutation	SNP	G	G	A	rs140103246		TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:123814011G>A	ENST00000321252.2	-	1	569	c.535C>T	c.(535-537)Cgt>Tgt	p.R179C		NM_001005187.1	NP_001005187.1	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T, member 1	179					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R179C(1)		breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		CAACTGTCACGAAAGAAGTGG	0.572000													37	34					0	0	1	0	0
ATM	472	broad.mit.edu	37	11	108160394	108160394	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:108160394G>A	ENST00000278616.4	+	29	4687	c.4302G>A	c.(4300-4302)aaG>aaA	p.K1434K	ATM_ENST00000452508.2_Silent_p.K1434K	NM_000051.3	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	1434					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		ATGTTTATAAGAAGCACAGAA	0.323000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			20	1					0	0	1	0	0
PRRG2	5639	broad.mit.edu	37	19	50086859	50086859	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:50086859G>C	ENST00000246794.5	+	3	315	c.146G>C	c.(145-147)aGa>aCa	p.R49T	PRRG2_ENST00000596700.1_Intron	NM_000951.2	NP_000942.1	O14669	TMG2_HUMAN	proline rich Gla (G-carboxyglutamic acid) 2	49						extracellular region|integral to plasma membrane	calcium ion binding			lung(1)|skin(1)|soft_tissue(1)	3		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00295)|GBM - Glioblastoma multiforme(134;0.0121)		CGGATTCCAAGAGCCAACCAC	0.572000													104	74					0	0	1	0	0
KNTC1	9735	broad.mit.edu	37	12	123068856	123068856	+	Missense_Mutation	SNP	A	A	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:123068856A>T	ENST00000333479.7	+	35	3472	c.3295A>T	c.(3295-3297)Act>Tct	p.T1099S	KNTC1_ENST00000450485.2_Intron	NM_014708.4	NP_055523.1	P50748	KNTC1_HUMAN	kinetochore associated 1	1099					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(12)|kidney(8)|large_intestine(12)|lung(20)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	72	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		CAATGCTGACACTGGGAAATT	0.418000													51	56					0	0	1	0	0
GPR31	2853	broad.mit.edu	37	6	167570376	167570376	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:167570376C>G	ENST00000366834.1	-	1	1441	c.944G>C	c.(943-945)aGa>aCa	p.R315T		NM_005299.2	NP_005290.2	O00270	GPR31_HUMAN	G protein-coupled receptor 31	315						integral to plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(4)|large_intestine(4)|lung(7)|prostate(1)	17		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;4.81e-20)|BRCA - Breast invasive adenocarcinoma(81;4.45e-06)|GBM - Glioblastoma multiforme(31;0.00492)		ATAGGAGTCTCTGGGGTTGAA	0.537000													38	27					0	0	1	0	0
NXF3	56000	broad.mit.edu	37	X	102337230	102337230	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chrX:102337230G>C	ENST00000395065.3	-	9	944	c.843C>G	c.(841-843)gaC>gaG	p.D281E	NXF3_ENST00000425644.1_5'UTR|NXF3_ENST00000425463.2_Missense_Mutation_p.D192E	NM_022052.1	NP_071335.1	Q9H4D5	NXF3_HUMAN	nuclear RNA export factor 3	281						cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(2)|lung(15)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26						CTGGGCTTCTGTCCGCACACT	0.532000													21	137					0	0	1	0	0
ALPI	248	broad.mit.edu	37	2	233321156	233321156	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:233321156C>T	ENST00000295463.3	+	2	242	c.165C>T	c.(163-165)ctC>ctT	p.L55L		NM_001631.3	NP_001622.2	P09923	PPBI_HUMAN	alkaline phosphatase, intestinal	55					phosphorylation	anchored to membrane|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|prostate(2)|upper_aerodigestive_tract(1)	24		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.64e-16)|Kidney(3;9.71e-08)|KIRC - Kidney renal clear cell carcinoma(3;2.74e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000763)|Lung(119;0.00564)|LUSC - Lung squamous cell carcinoma(224;0.00746)		CCAAGAACCTCATCCTCTTCC	0.637000													21	24					0	0	1	0	0
NR2F1	7025	broad.mit.edu	37	5	92923969	92923969	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:92923969G>A	ENST00000327111.3	+	2	2497	c.810G>A	c.(808-810)ccG>ccA	p.P270P		NM_005654.4	NP_005645.1	P10589	COT1_HUMAN	nuclear receptor subfamily 2, group F, member 1	270					negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|large_intestine(6)|lung(2)|ovary(3)|prostate(1)|skin(1)|urinary_tract(2)	21		all_cancers(142;1.62e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0126)|Lung NSC(167;0.0155)|Ovarian(174;0.0218)|Prostate(281;0.173)|Colorectal(57;0.19)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0416)|all cancers(79;9.57e-18)		GCTCTATGCCGCTGCACGTGG	0.667000													48	33					0	0	1	0	0
ANKRD30BP3	338579	broad.mit.edu	37	10	45652303	45652303	+	RNA	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr10:45652303G>A	ENST00000427229.2	+	0	1817																											AAGCTTGGTGGAAAAACCACC	0.483000													17	19					0	0	1	0	0
NCOA7	135112	broad.mit.edu	37	6	126242143	126242143	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:126242143G>C	ENST00000368357.3	+	13	2651	c.2299G>C	c.(2299-2301)Gac>Cac	p.D767H	NCOA7_ENST00000229634.9_Missense_Mutation_p.D652H|NCOA7_ENST00000392477.2_Missense_Mutation_p.D767H	NM_001199619.1|NM_001199620.1	NP_001186548.1|NP_001186549.1	Q8NI08	NCOA7_HUMAN	nuclear receptor coactivator 7	767					cell wall macromolecule catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(6)|lung(16)|ovary(1)|skin(1)|soft_tissue(1)|urinary_tract(2)	39				UCEC - Uterine corpus endometrioid carcinoma (4;0.0803)|GBM - Glioblastoma multiforme(226;0.0193)|all cancers(137;0.237)		CTACTATGAAGACGAGGACGA	0.527000													27	23					0	0	1	0	0
PLSCR2	57047	broad.mit.edu	37	3	146173116	146173116	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:146173116C>G	ENST00000497985.1	-	6	889	c.450G>C	c.(448-450)ttG>ttC	p.L150F	PLSCR2_ENST00000336685.2_Missense_Mutation_p.L77F	NM_001199978.1	NP_001186907.1	Q9NRY7	PLS2_HUMAN	phospholipid scramblase 2	77					phospholipid scrambling	integral to membrane|plasma membrane	calcium ion binding|phospholipid scramblase activity			endometrium(2)|large_intestine(5)|lung(7)|stomach(1)	15						CAGTAATCCTCAAGGTAAAAG	0.433000													72	51					0	0	1	0	0
ASIC4	55515	broad.mit.edu	37	2	220379882	220379882	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:220379882G>C	ENST00000358078.4	+	1	831	c.817G>C	c.(817-819)Gac>Cac	p.D273H	AC053503.11_ENST00000429882.1_RNA|ASIC4_ENST00000347842.3_Missense_Mutation_p.D273H			Q96FT7	ACCN4_HUMAN	acid-sensing (proton-gated) ion channel family member 4	273						integral to plasma membrane	sodium channel activity|sodium ion transmembrane transporter activity										GCCCCCCAAAGACCGGGATGG	0.627000													12	21					0	0	1	0	0
PLOD1	5351	broad.mit.edu	37	1	12027132	12027132	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:12027132C>G	ENST00000196061.4	+	16	1766	c.1739C>G	c.(1738-1740)tCt>tGt	p.S580C	PLOD1_ENST00000376369.3_Missense_Mutation_p.S627C	NM_000302.3	NP_000293.2	Q02809	PLOD1_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1	580					epidermis development|hydroxylysine biosynthetic process|protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein homodimerization activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	29	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000809)|KIRC - Kidney renal clear cell carcinoma(229;0.00267)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)	Minoxidil(DB00350)|Succinic acid(DB00139)|Vitamin C(DB00126)	GGCCAGTGGTCTCTGGGCAAC	0.632000													4	97					0	0	1	0	0
BRWD1	54014	broad.mit.edu	37	21	40571073	40571073	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr21:40571073C>T	ENST00000342449.3	-	40	5347	c.5269G>A	c.(5269-5271)Gag>Aag	p.E1757K	BRWD1_ENST00000333229.2_Missense_Mutation_p.E1757K|BRWD1_ENST00000380800.3_Missense_Mutation_p.E1757K	NM_033656.3	NP_387505.1	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	1757					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				cervix(2)|endometrium(6)|kidney(8)|large_intestine(14)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(2)	58		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				GAGTCTTCCTCAGAAGACTCT	0.428000													32	82					0	0	1	0	0
AQP4	361	broad.mit.edu	37	18	24436295	24436295	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr18:24436295C>G	ENST00000383168.4	-	5	980	c.852G>C	c.(850-852)agG>agC	p.R284S	AQP4_ENST00000440832.3_Missense_Mutation_p.R262S|AQP4_ENST00000581374.1_Missense_Mutation_p.R262S|AQP4-AS1_ENST00000579964.1_RNA|AQP4_ENST00000583022.1_5'UTR|AQP4-AS1_ENST00000582605.1_RNA	NM_001650.4|NM_004028.3	NP_001641.1|NP_004019.1	P55087	AQP4_HUMAN	aquaporin 4	284					cellular response to interferon-gamma|excretion|nervous system development	cytoplasm|external side of plasma membrane|integral to plasma membrane	water channel activity			kidney(2)|large_intestine(3)|lung(5)|skin(1)	11	all_cancers(21;0.0172)|Lung NSC(5;0.00299)|all_lung(6;0.00747)|Ovarian(20;0.124)					CTACCTGACTCCTGTTGTCCT	0.483000													5	279					0	0	1	0	0
LARP4B	23185	broad.mit.edu	37	10	871107	871107	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr10:871107C>G	ENST00000316157.3	-	12	1422	c.1382G>C	c.(1381-1383)aGa>aCa	p.R461T		NM_015155.1	NP_055970.1	Q92615	LAR4B_HUMAN	La ribonucleoprotein domain family, member 4B	461							nucleotide binding|RNA binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(2)|skin(2)|urinary_tract(2)	38						AATCCGTGTTCTAGTTTGACC	0.493000													5	147					0	0	1	0	0
GAD2	2572	broad.mit.edu	37	10	26575295	26575295	+	Missense_Mutation	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr10:26575295C>A	ENST00000376261.3	+	13	1761	c.1258C>A	c.(1258-1260)Caa>Aaa	p.Q420K	GAD2_ENST00000259271.3_Missense_Mutation_p.Q420K	NM_001134366.1	NP_001127838.1	Q05329	DCE2_HUMAN	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	420					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(26)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	48					L-Glutamic Acid(DB00142)	GAATTGCAACCAAATGCATGC	0.368000													13	72					0.000151284	0.000153597	1	1	0
RBBP7	5931	broad.mit.edu	37	X	16887338	16887338	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chrX:16887338C>G	ENST00000380087.2	-	2	382	c.22G>C	c.(22-24)Gaa>Caa	p.E8Q	RBBP7_ENST00000404022.1_Missense_Mutation_p.E8Q|RBBP7_ENST00000380084.4_Missense_Mutation_p.E52Q			Q16576	RBBP7_HUMAN	retinoblastoma binding protein 7	8					cell proliferation|cellular heat acclimation|CenH3-containing nucleosome assembly at centromere|DNA replication|multicellular organismal development|negative regulation of cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex|NuRD complex	protein binding			biliary_tract(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(2)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	25	Hepatocellular(33;0.0997)					ACAGTATCTTCAAACACTGAA	0.423000													4	57					0	0	1	0	0
ARHGEF19	128272	broad.mit.edu	37	1	16534508	16534508	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:16534508G>C	ENST00000270747.3	-	3	761	c.625C>G	c.(625-627)Ctg>Gtg	p.L209V		NM_153213.3	NP_694945.2	Q8IW93	ARHGJ_HUMAN	Rho guanine nucleotide exchange factor (GEF) 19	209					regulation of actin cytoskeleton organization	intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(1)|lung(3)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	12		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|Colorectal(212;3.48e-07)|COAD - Colon adenocarcinoma(227;2.19e-05)|BRCA - Breast invasive adenocarcinoma(304;9.46e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.0117)|READ - Rectum adenocarcinoma(331;0.0649)		CCCAGGCGCAGAGAAGAGTGC	0.672000													18	41					0	0	1	0	0
GPRC6A	222545	broad.mit.edu	37	6	117114160	117114160	+	Silent	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:117114160G>C	ENST00000310357.3	-	6	1947	c.1926C>G	c.(1924-1926)ctC>ctG	p.L642L	GPRC6A_ENST00000530250.1_Silent_p.L467L|GPRC6A_ENST00000368549.3_Silent_p.L571L	NM_148963.2	NP_683766.2	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6, member A	642					response to amino acid stimulus		G-protein coupled receptor activity			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|liver(1)|lung(24)|ovary(5)|pancreas(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)	65		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		TGGCAAAATTGAGGAAATGAC	0.418000													49	37					0	0	1	0	0
ZSCAN29	146050	broad.mit.edu	37	15	43656116	43656116	+	Missense_Mutation	SNP	G	G	A	rs143986040	byFrequency	TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr15:43656116G>A	ENST00000396976.2	-	4	1821	c.1687C>T	c.(1687-1689)Cgt>Tgt	p.R563C	ZSCAN29_ENST00000562072.1_Intron|ZSCAN29_ENST00000568898.1_Intron|ZSCAN29_ENST00000396972.1_Intron	NM_152455.3	NP_689668.3	Q8IWY8	ZSC29_HUMAN	zinc finger and SCAN domain containing 29	563					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(9)|lung(7)|skin(2)	24		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.97e-07)		ATCTTACCACGGGGGCTTTGG	0.448000													13	42					0	0	1	0	0
LOC101929066	101929066	broad.mit.edu	37	8	17944618	17944618	+	RNA	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr8:17944618C>G	ENST00000499554.2	+	0	455				CTD-2547L16.1_ENST00000521775.1_RNA|CTD-2547L16.1_ENST00000517747.1_RNA|CTD-2547L16.1_ENST00000505114.2_RNA|CTD-2547L16.1_ENST00000517798.1_RNA																							TAAATTCCATCACATTACCAC	0.363000													16	4					0	0	1	0	0
ZNF165	7718	broad.mit.edu	37	6	28053307	28053307	+	Nonsense_Mutation	SNP	G	G	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:28053307G>T	ENST00000377325.1	+	2	605	c.49G>T	c.(49-51)Gaa>Taa	p.E17*		NM_003447.3	NP_003438.1	P49910	ZN165_HUMAN	zinc finger protein 165	17					viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(14)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						TCCAGAGGATGAAGGACTTCT	0.438000													107	67					1.54263e-40	1.69179e-40	1	1	0
C1orf35	79169	broad.mit.edu	37	1	228288845	228288845	+	Missense_Mutation	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:228288845C>A	ENST00000272139.4	-	8	1013	c.779G>T	c.(778-780)gGc>gTc	p.G260V	C1orf35_ENST00000472617.1_5'UTR	NM_024319.2	NP_077295.1	Q9BU76	MMTA2_HUMAN	chromosome 1 open reading frame 35	260										large_intestine(1)|lung(1)|skin(1)	3		Prostate(94;0.0488)				GGCCTCAGAGCCTCTGTCATG	0.627000													40	61					1.7489e-18	1.87383e-18	1	1	0
CDH4	1002	broad.mit.edu	37	20	60508098	60508098	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr20:60508098G>A	ENST00000360469.5	+	14	2383	c.2295G>A	c.(2293-2295)acG>acA	p.T765T	CDH4_ENST00000543233.1_Silent_p.T691T	NM_001794.3	NP_001785.2	P55283	CADH4_HUMAN	cadherin 4, type 1, R-cadherin (retinal)	765					adherens junction organization|cell junction assembly		calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(2)|lung(25)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			AGCGCCACACGAAGCAGCTGC	0.642000													32	72					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79399178	79399178	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:79399178G>C	ENST00000264895.6	+	55	8501	c.8061G>C	c.(8059-8061)gaG>gaC	p.E2687D		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2682	Calx-beta 2.				cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						GGGTTAACGAGAGCGCTGGTT	0.418000													7	7					0	0	1	0	0
ZNF70	7621	broad.mit.edu	37	22	24087187	24087187	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr22:24087187G>C	ENST00000341976.3	-	2	601	c.141C>G	c.(139-141)atC>atG	p.I47M		NM_021916.2	NP_068735.1	Q9UC06	ZNF70_HUMAN	zinc finger protein 70	47						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|urinary_tract(1)	21						TCTCCTTGTAGATCACAGCCA	0.488000													7	111					0	0	1	0	0
NUDT22	84304	broad.mit.edu	37	11	63994361	63994361	+	Silent	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:63994361C>A	ENST00000279206.3	+	2	393	c.237C>A	c.(235-237)ctC>ctA	p.L79L	NUDT22_ENST00000441250.2_Silent_p.L79L	NM_001128612.2|NM_032344.2	NP_001122084.1|NP_115720	Q9BRQ3	NUD22_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 22	79							hydrolase activity			breast(1)|endometrium(1)|large_intestine(2)|lung(4)	8						CACAGCTGCTCCTGCGCCTGG	0.662000													44	82					1.7489e-18	1.87383e-18	1	1	0
CDH7	1005	broad.mit.edu	37	18	63525149	63525149	+	Missense_Mutation	SNP	A	A	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr18:63525149A>G	ENST00000536984.2	+	8	2027	c.1333A>G	c.(1333-1335)Aat>Gat	p.N445D	CDH7_ENST00000323011.3_Missense_Mutation_p.N445D|CDH7_ENST00000397968.2_Missense_Mutation_p.N445D			Q9ULB5	CADH7_HUMAN	cadherin 7, type 2	445	Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(43)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	80		Esophageal squamous(42;0.129)				TCGAGAGACAAATGCTATTCA	0.418000													25	59					0	0	1	0	0
CHD2	1106	broad.mit.edu	37	15	93558004	93558004	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr15:93558004C>G	ENST00000394196.4	+	37	5839	c.4771C>G	c.(4771-4773)Ctg>Gtg	p.L1591V	CHD2_ENST00000557381.1_Missense_Mutation_p.L1591V	NM_001271.3	NP_001262.3	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1591					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	47	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			CCGGGACTCTCTGATATCTCA	0.507000													5	166					0	0	1	0	0
ABLIM1	3983	broad.mit.edu	37	10	116417887	116417887	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr10:116417887C>T	ENST00000277895.5	-	1	170	c.73G>A	c.(73-75)Gag>Aag	p.E25K	ABLIM1_ENST00000533213.2_Intron|ABLIM1_ENST00000369252.4_Intron	NM_002313.5	NP_002304.3	O14639	ABLM1_HUMAN	actin binding LIM protein 1	25					axon guidance|cytoskeleton organization|organ morphogenesis|visual perception	actin cytoskeleton|cytoplasm	actin binding|zinc ion binding	p.E25K(1)		breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	30		Colorectal(252;0.0373)|Breast(234;0.231)		Epithelial(162;0.0132)|all cancers(201;0.0383)		CTGGTTCTCTCAGATGAGGTG	0.517000													80	110					0	0	1	0	0
GPBAR1	151306	broad.mit.edu	37	2	219127966	219127966	+	Silent	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:219127966C>A	ENST00000522678.1	+	2	1387	c.519C>A	c.(517-519)ctC>ctA	p.L173L	GPBAR1_ENST00000521462.1_Silent_p.L173L|GPBAR1_ENST00000479077.1_Silent_p.L173L|GPBAR1_ENST00000519574.1_Silent_p.L173L	NM_001077191.1	NP_001070659.1	Q8TDU6	GPBAR_HUMAN	G protein-coupled bile acid receptor 1	173						integral to membrane|plasma membrane	G-protein coupled receptor activity			cervix(1)|kidney(1)|large_intestine(1)|ovary(1)	4		Renal(207;0.0474)		Epithelial(149;7.19e-07)|all cancers(144;0.000131)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCTATGGGCTCCTGCTGCCCG	0.672000													26	23					2.24059e-21	2.41175e-21	1	1	0
ELAVL4	1996	broad.mit.edu	37	1	50666550	50666550	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:50666550G>C	ENST00000371824.1	+	7	1058	c.801G>C	c.(799-801)atG>atC	p.M267I	ELAVL4_ENST00000371827.1_Missense_Mutation_p.M267I|ELAVL4_ENST00000371819.1_Missense_Mutation_p.M272I|ELAVL4_ENST00000448907.2_Missense_Mutation_p.M270I|ELAVL4_ENST00000371821.1_Missense_Mutation_p.M286I|ELAVL4_ENST00000357083.4_Missense_Mutation_p.M284I|ELAVL4_ENST00000371823.4_Missense_Mutation_p.M281I			P26378	ELAV4_HUMAN	ELAV like neuron-specific RNA binding protein 4	281					mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			NS(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|liver(2)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	32						TTGATGGAATGACAAGCCTTG	0.532000													6	140					0	0	1	0	0
PCDHB4	56131	broad.mit.edu	37	5	140502019	140502019	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:140502019C>G	ENST00000194152.1	+	1	439	c.439C>G	c.(439-441)Ccg>Gcg	p.P147A		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		147	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAATAGCCAGCCGGGTACTCT	0.393000													21	48					0	0	1	0	0
EVC2	132884	broad.mit.edu	37	4	5624594	5624594	+	Missense_Mutation	SNP	A	A	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:5624594A>T	ENST00000310917.2	-	14	2662	c.1931T>A	c.(1930-1932)cTg>cAg	p.L644Q	EVC2_ENST00000344408.5_Missense_Mutation_p.L724Q|EVC2_ENST00000344938.1_Missense_Mutation_p.L724Q	NM_001166136.1	NP_001159608.1	Q86UK5	LBN_HUMAN	Ellis van Creveld syndrome 2	724						integral to membrane				NS(2)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(32)|lung(28)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	81						ACGCTCCTGCAGCTCCTCCAG	0.652000													63	69					0	0	1	0	0
MAN2B2	23324	broad.mit.edu	37	4	6610897	6610897	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:6610897G>A	ENST00000285599.3	+	12	1914	c.1878G>A	c.(1876-1878)gtG>gtA	p.V626V	MAN2B2_ENST00000504960.1_3'UTR|MAN2B2_ENST00000504248.1_Silent_p.V575V	NM_015274.1	NP_056089.1	Q9Y2E5	MA2B2_HUMAN	mannosidase, alpha, class 2B, member 2	626					mannose metabolic process	extracellular region	alpha-mannosidase activity|carbohydrate binding|zinc ion binding			breast(2)|cervix(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(9)|ovary(4)|prostate(2)|skin(2)|urinary_tract(1)	30						ACGGGGATGTGAAACAGGGCC	0.572000													27	22					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179659214	179659214	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:179659214C>G	ENST00000589042.1	-	8	1534	c.1310G>C	c.(1309-1311)aGa>aCa	p.R437T	TTN_ENST00000342992.6_Missense_Mutation_p.R437T|TTN_ENST00000359218.5_Missense_Mutation_p.R437T|TTN_ENST00000342175.6_Missense_Mutation_p.R437T|TTN_ENST00000591111.1_Missense_Mutation_p.R437T|TTN_ENST00000460472.2_Missense_Mutation_p.R437T|TTN_ENST00000360870.5_Missense_Mutation_p.R437T	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	437							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCTCTCACTCTGGCCATATC	0.478000													6	138					0	0	1	0	0
ANKS1A	23294	broad.mit.edu	37	6	34962090	34962090	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:34962090G>C	ENST00000360359.3	+	10	1452	c.1314G>C	c.(1312-1314)atG>atC	p.M438I	ANKS1A_ENST00000535627.1_Intron	NM_015245.2	NP_056060.2	Q92625	ANS1A_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1A	438						cytoplasm	protein binding			cervix(2)|endometrium(3)|large_intestine(4)|lung(16)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31						TTCTGTCCATGAGACCTAGGA	0.458000													56	36					0	0	1	0	0
BICC1	80114	broad.mit.edu	37	10	60566350	60566350	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr10:60566350G>A	ENST00000373886.3	+	16	2192	c.2188G>A	c.(2188-2190)Gac>Aac	p.D730N	BICC1_ENST00000263103.1_Missense_Mutation_p.D356N	NM_001080512.1	NP_001073981.1	Q9H694	BICC1_HUMAN	bicaudal C homolog 1 (Drosophila)	730					multicellular organismal development		RNA binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	44						TCAGGCATTTGACTATGAACA	0.343000													28	110					0	0	1	0	0
MYBPC1	4604	broad.mit.edu	37	12	102056180	102056180	+	Missense_Mutation	SNP	A	A	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:102056180A>G	ENST00000549145.1	+	20	2141	c.2041A>G	c.(2041-2043)Agg>Ggg	p.R681G	MYBPC1_ENST00000361685.2_Missense_Mutation_p.R693G|MYBPC1_ENST00000550501.1_Intron|MYBPC1_ENST00000536007.1_Missense_Mutation_p.R649G|MYBPC1_ENST00000545503.2_Missense_Mutation_p.R668G|MYBPC1_ENST00000547509.1_Missense_Mutation_p.R654G|MYBPC1_ENST00000441232.1_Missense_Mutation_p.R668G|MYBPC1_ENST00000361466.2_Missense_Mutation_p.R693G|MYBPC1_ENST00000360610.2_Missense_Mutation_p.R668G|MYBPC1_ENST00000547405.1_Missense_Mutation_p.R642G|MYBPC1_ENST00000541119.1_Missense_Mutation_p.R656G|MYBPC1_ENST00000551300.1_Missense_Mutation_p.R569G|MYBPC1_ENST00000553190.1_Missense_Mutation_p.R668G|MYBPC1_ENST00000392934.3_Missense_Mutation_p.R655G|MYBPC1_ENST00000452455.2_Missense_Mutation_p.R668G|MYBPC1_ENST00000550270.1_Missense_Mutation_p.R668G			Q00872	MYPC1_HUMAN	myosin binding protein C, slow type	668	Fibronectin type-III 1.				cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	57						CAGGTGGATGAGGCTGAATTT	0.403000													3	54					0	0	1	0	0
EIF4G3	8672	broad.mit.edu	37	1	21155725	21155725	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:21155725C>T	ENST00000602326.1	-	29	4535	c.3952G>A	c.(3952-3954)Gat>Aat	p.D1318N	EIF4G3_ENST00000537738.1_Missense_Mutation_p.D802N|EIF4G3_ENST00000374937.3_Missense_Mutation_p.D1318N|EIF4G3_ENST00000264211.8_Missense_Mutation_p.D1312N|EIF4G3_ENST00000536266.1_Missense_Mutation_p.D916N|EIF4G3_ENST00000374935.3_Missense_Mutation_p.D1032N|EIF4G3_ENST00000400422.1_Missense_Mutation_p.D1312N	NM_001198802.1	NP_001185731.1	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4 gamma, 3	1312	MI.				interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(18)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(1)|urinary_tract(3)	70		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		TGGGGAATATCAATGGCCATG	0.363000													19	40					0	0	1	0	0
GMPR2	51292	broad.mit.edu	37	14	24707760	24707760	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr14:24707760G>A	ENST00000557854.1	+	8	1337	c.1060G>A	c.(1060-1062)Gaa>Aaa	p.E354K	GMPR2_ENST00000348719.7_Missense_Mutation_p.E336K|GMPR2_ENST00000559836.1_Intron|GMPR2_ENST00000559910.1_Intron|GMPR2_ENST00000399440.2_Intron|GMPR2_ENST00000456667.3_Intron|GMPR2_ENST00000420554.2_Intron|GMPR2_ENST00000355299.4_Intron|GMPR2_ENST00000559104.1_Intron	NM_001283022.1	NP_001269951.1	Q9P2T1	GMPR2_HUMAN	guanosine monophosphate reductase 2	0					nucleotide metabolic process|purine base metabolic process|purine-containing compound salvage	cytosol	GMP reductase activity|metal ion binding			large_intestine(4)|lung(3)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	12				GBM - Glioblastoma multiforme(265;0.0181)		AAGGAATCCAGAAGGAGAAGA	0.468000													26	6					0	0	1	0	0
PIK3CB	5291	broad.mit.edu	37	3	138417757	138417757	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:138417757C>T	ENST00000477593.1	-	12	1835	c.1762G>A	c.(1762-1764)Gtt>Att	p.V588I	PIK3CB_ENST00000544716.1_Missense_Mutation_p.V34I|PIK3CB_ENST00000289153.2_Missense_Mutation_p.V588I			P42338	PK3CB_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	588	PI3K helical.				activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			NS(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	41						ACCTGAGCAACATCCTCAAGT	0.363000													39	114					0	0	1	0	0
PPP1R15A	23645	broad.mit.edu	37	19	49379127	49379127	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:49379127C>T	ENST00000200453.5	+	3	2191	c.1922C>T	c.(1921-1923)tCg>tTg	p.S641L		NM_014330.3	NP_055145.3	O75807	PR15A_HUMAN	protein phosphatase 1, regulatory subunit 15A	641					apoptosis|cell cycle arrest|regulation of translation|response to DNA damage stimulus	endoplasmic reticulum	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(8)|skin(2)|urinary_tract(1)	23		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000244)|all cancers(93;0.000694)|GBM - Glioblastoma multiforme(486;0.0222)|Epithelial(262;0.033)		TCTGTCCCTTCGTCCCCAGTC	0.682000													185	162					0	0	1	0	0
DIABLO	56616	broad.mit.edu	37	12	122702861	122702861	+	Silent	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:122702861G>C	ENST00000464942.2	-	2	1501	c.108C>G	c.(106-108)ctC>ctG	p.L36L	RP11-512M8.5_ENST00000535844.1_3'UTR|DIABLO_ENST00000413918.1_Intron|DIABLO_ENST00000443649.3_Silent_p.L89L|DIABLO_ENST00000353548.6_Intron|DIABLO_ENST00000267169.6_Silent_p.L36L	NM_001278304.1	NP_001265233.1	Q9NR28	DBLOH_HUMAN	diablo, IAP-binding mitochondrial protein	89					activation of caspase activity by cytochrome c|induction of apoptosis via death domain receptors	CD40 receptor complex|cytosol|internal side of plasma membrane|mitochondrial intermembrane space	protein binding			breast(1)|endometrium(3)|large_intestine(1)|lung(1)|ovary(1)	7	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000302)|Epithelial(86;0.00051)|BRCA - Breast invasive adenocarcinoma(302;0.223)		TGGTCTGAGAGAGAAAGGTAG	0.388000													4	95					0	0	1	0	0
ABCC11	85320	broad.mit.edu	37	16	48210950	48210950	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr16:48210950G>A	ENST00000394747.1	-	24	3772	c.3423C>T	c.(3421-3423)atC>atT	p.I1141I	ABCC11_ENST00000565329.1_5'UTR|ABCC11_ENST00000353782.5_Silent_p.I1141I|ABCC11_ENST00000356608.2_Silent_p.I1141I|ABCC11_ENST00000394748.1_Silent_p.I1141I	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	1141	ABC transporter 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				CCTGAAATATGATTTCCCCAT	0.493000													27	57					0	0	1	0	0
DAZAP1	26528	broad.mit.edu	37	19	1434829	1434829	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:1434829C>T	ENST00000233078.4	+	12	1303	c.1142C>T	c.(1141-1143)tCg>tTg	p.S381L	DAZAP1_ENST00000336761.6_3'UTR	NM_018959.2	NP_061832.2	Q96EP5	DAZP1_HUMAN	DAZ associated protein 1	381	Pro-rich.		S -> T (in a breast cancer sample; somatic mutation).		cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleotide binding|RNA binding			breast(2)|endometrium(2)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(1)	9		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGCCAGGGTcggggggcccc	0.711000													16	13					0	0	1	0	0
ZBED6CL	113763	broad.mit.edu	37	7	150027548	150027548	+	Missense_Mutation	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:150027548C>A	ENST00000343855.4	+	1	611	c.55C>A	c.(55-57)Cag>Aag	p.Q19K	LRRC61_ENST00000493307.1_Intron|LRRC61_ENST00000323078.7_Intron|LRRC61_ENST00000359623.4_Intron	NM_138434.2	NP_612443.1			ZBED6 C-terminal like																		GGTGCTGCCCCAGCTGCGCTA	0.647000													6	128					0.000157383	0.000159441	1	1	0
ZFYVE1	53349	broad.mit.edu	37	14	73460022	73460022	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr14:73460022G>A	ENST00000556143.1	-	4	1752	c.1032C>T	c.(1030-1032)ttC>ttT	p.F344F	ZFYVE1_ENST00000318876.5_Silent_p.F344F|ZFYVE1_ENST00000553891.1_Silent_p.F344F	NM_001281735.1|NM_021260.2	NP_001268664.1|NP_067083.1	Q9HBF4	ZFYV1_HUMAN	zinc finger, FYVE domain containing 1	344						endoplasmic reticulum|Golgi stack|perinuclear region of cytoplasm	1-phosphatidylinositol binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(17)|ovary(1)|prostate(2)|skin(1)	35		all_lung(585;1.33e-09)		OV - Ovarian serous cystadenocarcinoma(108;1.6e-46)|BRCA - Breast invasive adenocarcinoma(234;0.00349)		CCAGCTTCCGGAACCGGTCCT	0.493000													5	47					0	0	1	0	0
CCP110	9738	broad.mit.edu	37	16	19556150	19556150	+	Nonsense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr16:19556150C>G	ENST00000396212.2	+	10	2952	c.2516C>G	c.(2515-2517)tCa>tGa	p.S839*	CCP110_ENST00000381396.5_Nonsense_Mutation_p.S839*|CCP110_ENST00000396208.2_Nonsense_Mutation_p.S839*	NM_014711.4	NP_055526	O43303	CP110_HUMAN	centriolar coiled coil protein 110kDa	839					centriole replication|G2/M transition of mitotic cell cycle|regulation of cytokinesis	centriole|cytosol	protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(8)|stomach(3)|urinary_tract(1)	21						AGTTTTCAGTCAGAAGCACCA	0.358000													27	135					0	0	1	0	0
EDAR	10913	broad.mit.edu	37	2	109545682	109545682	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:109545682C>T	ENST00000409271.1	-	5	771	c.328G>A	c.(328-330)Gac>Aac	p.D110N	EDAR_ENST00000258443.2_Missense_Mutation_p.D110N|EDAR_ENST00000376651.1_Missense_Mutation_p.D110N			Q9UNE0	EDAR_HUMAN	ectodysplasin A receptor	110			D -> A (in EDA).		apoptosis|cell differentiation	integral to membrane	protein binding|transmembrane receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	16						CACTCAGCGTCATTCTCCATG	0.592000													22	21					0	0	1	0	0
DBNL	28988	broad.mit.edu	37	7	44091445	44091445	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:44091445G>A	ENST00000494774.1	+	3	177	c.156G>A	c.(154-156)gaG>gaA	p.E52E	DBNL_ENST00000452943.1_Silent_p.E52E|DBNL_ENST00000456905.1_Silent_p.E52E|DBNL_ENST00000448521.1_Silent_p.E52E|DBNL_ENST00000497184.1_3'UTR|DBNL_ENST00000490734.2_Intron|DBNL_ENST00000440166.1_Intron|DBNL_ENST00000468694.1_Silent_p.E52E	NM_014063.6	NP_054782.2	Q9UJU6	DBNL_HUMAN	drebrin-like	52	ADF-H.				activation of JUN kinase activity|cellular component disassembly involved in apoptosis|endocytosis|Rac protein signal transduction	cell cortex|cytoskeleton|cytosol|lamellipodium	actin binding|enzyme activator activity|identical protein binding			breast(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)|stomach(1)	12						GCCTGGAGGAGATGGTGGAGG	0.592000													5	59					0	0	1	0	0
BBS1	582	broad.mit.edu	37	11	66278499	66278499	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:66278499G>A	ENST00000419755.3	+	2	252	c.174G>A	c.(172-174)tcG>tcA	p.S58S	BBS1_ENST00000537537.1_5'UTR|BBS1_ENST00000318312.7_Silent_p.S21S|BBS1_ENST00000393994.2_Silent_p.S21S|BBS1_ENST00000455748.2_Silent_p.S21S|BBS1_ENST00000529766.1_3'UTR																							AGGCCAATTCGAAGTGGTTGG	0.527000													5	365					0	0	1	0	0
ADSSL1	122622	broad.mit.edu	37	14	105207471	105207471	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr14:105207471C>G	ENST00000332972.5	+	8	972	c.813C>G	c.(811-813)atC>atG	p.I271M	ADSSL1_ENST00000330877.2_Missense_Mutation_p.I228M	NM_199165.1	NP_954634.1	Q8N142	PURA1_HUMAN	adenylosuccinate synthase like 1	228					AMP biosynthetic process|immune system process|purine base metabolic process	cytosol	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			central_nervous_system(1)|cervix(1)|kidney(1)|lung(5)|ovary(2)|prostate(1)	11		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00153)|OV - Ovarian serous cystadenocarcinoma(23;0.0148)|Epithelial(46;0.0396)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.18)	L-Aspartic Acid(DB00128)	CTGAGCGGATCAGACCCATGG	0.622000													40	5					0	0	1	0	0
ATP2A2	488	broad.mit.edu	37	12	110782744	110782744	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:110782744G>A	ENST00000395494.2	+	16	3057	c.2494G>A	c.(2494-2496)Gac>Aac	p.D832N	ATP2A2_ENST00000539276.2_Missense_Mutation_p.D859N|ATP2A2_ENST00000308664.6_Missense_Mutation_p.D859N			P16615	AT2A2_HUMAN	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	859					ATP biosynthetic process|cell adhesion|epidermis development|platelet activation|sarcoplasmic reticulum calcium ion transport	integral to plasma membrane|microsome|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|protein C-terminus binding|S100 alpha binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(10)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(1)	38						CATTGCTGCTGACGGTGGTCC	0.532000													50	40					0	0	1	0	0
ADD1	118	broad.mit.edu	37	4	2906529	2906529	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:2906529G>A	ENST00000355842.3	+	11	2063	c.1200G>A	c.(1198-1200)ctG>ctA	p.L400L	ADD1_ENST00000398123.2_Silent_p.L400L|ADD1_ENST00000513328.2_Silent_p.L400L|ADD1_ENST00000503455.2_Silent_p.L400L|ADD1_ENST00000264758.7_Silent_p.L400L|ADD1_ENST00000398129.1_Silent_p.L400L|ADD1_ENST00000446856.1_Silent_p.L400L|ADD1_ENST00000398125.1_Silent_p.L400L			P35611	ADDA_HUMAN	adducin 1 (alpha)	400					actin filament bundle assembly|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|positive regulation of protein binding	cytosol|F-actin capping protein complex|nucleus|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding|transcription factor binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)	22				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		ACCCTGCTCTGAGAGAGAAGT	0.478000													51	82					0	0	1	0	0
SRSF5	6430	broad.mit.edu	37	14	70237198	70237198	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr14:70237198C>T	ENST00000553521.1	+	7	1834	c.381C>T	c.(379-381)ttC>ttT	p.F127F	SRSF5_ENST00000553635.1_Silent_p.F124F|SRSF5_ENST00000556587.1_3'UTR|SRSF5_ENST00000557154.1_Silent_p.F127F|SRSF5_ENST00000394366.2_Silent_p.F127F			Q13243	SRSF5_HUMAN	serine/arginine-rich splicing factor 5	127	RRM 2.				mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|protein binding|RNA binding			large_intestine(1)|liver(1)	2						TCAAAGATTTCATGAGACAAG	0.368000													31	7					0	0	1	0	0
JRKL	8690	broad.mit.edu	37	11	96123862	96123862	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:96123862G>C	ENST00000458427.1	+	1	705	c.49G>C	c.(49-51)Gat>Cat	p.D17H	JRKL_ENST00000332349.4_Missense_Mutation_p.D17H|JRKL_ENST00000546177.1_Intron	NM_003772.3	NP_003763.2	Q9Y4A0	JERKL_HUMAN	jerky homolog-like (mouse)	17	HTH psq-type.				central nervous system development|regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding			endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|upper_aerodigestive_tract(1)	11		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)		BRCA - Breast invasive adenocarcinoma(274;0.148)		AGATAAGCTTGATATAATAAA	0.403000													48	7					0	0	1	0	0
TONSL	4796	broad.mit.edu	37	8	145665842	145665842	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr8:145665842C>T	ENST00000409379.3	-	10	1211	c.1182G>A	c.(1180-1182)ctG>ctA	p.L394L		NM_013432.4	NP_038460.4	Q96HA7	TONSL_HUMAN	tonsoku-like, DNA repair protein	394					cytoplasmic sequestering of transcription factor|double-strand break repair via homologous recombination|replication fork processing	cytoplasm|nuclear replication fork	histone binding|transcription corepressor activity			biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|lung(14)|ovary(3)|prostate(1)|skin(1)	26						GTGCAATGTTCAGCCAGGTCT	0.687000													6	128					0	0	1	0	0
PBX2	5089	broad.mit.edu	37	6	32154196	32154196	+	Missense_Mutation	SNP	T	T	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:32154196T>C	ENST00000375050.4	-	9	1526	c.1256A>G	c.(1255-1257)gAg>gGg	p.E419G		NM_002586.4	NP_002577.2	P40425	PBX2_HUMAN	pre-B-cell leukemia homeobox 2	419							transcription factor binding			endometrium(1)|kidney(1)|lung(9)|ovary(1)|prostate(2)	14						CCCTGGTCCCTCCGTTGGGGA	0.567000													6	17					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	94690463	94690463	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:94690463G>A	ENST00000282020.4	+	15	2721	c.2463G>A	c.(2461-2463)caG>caA	p.Q821Q	GRID2_ENST00000510992.1_Silent_p.Q726Q	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	821					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	ACACAAAGCAGAAAGGAGGCG	0.522000													47	55					0	0	1	0	0
NPPA	4878	broad.mit.edu	37	1	11907678	11907678	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:11907678G>C	ENST00000376480.3	-	1	162	c.64C>G	c.(64-66)Cag>Gag	p.Q22E	NPPA_ENST00000376476.1_Intron|NPPA-AS1_ENST00000400892.2_RNA|NPPA-AS1_ENST00000446542.1_RNA	NM_006172.3	NP_006163.1	P01160	ANF_HUMAN	natriuretic peptide A	22					cGMP biosynthetic process|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size	extracellular region	hormone activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	10	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00149)|all_lung(284;0.00189)|Breast(348;0.00586)|Colorectal(325;0.0062)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0556)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.04e-06)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|Kidney(185;0.000733)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GCTCTGGTCTGACCTAGGAGC	0.572000													5	240					0	0	1	0	0
CLOCK	9575	broad.mit.edu	37	4	56325151	56325151	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:56325151C>G	ENST00000309964.4	-	10	950	c.700G>C	c.(700-702)Gaa>Caa	p.E234Q	CLOCK_ENST00000513440.1_Missense_Mutation_p.E234Q|CLOCK_ENST00000381322.1_Missense_Mutation_p.E234Q	NM_004898.3	NP_004889.1	O15516	CLOCK_HUMAN	clock circadian regulator	234					circadian rhythm|photoperiodism|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|transcription factor complex	DNA binding|histone acetyltransferase activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(8)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38	Lung NSC(11;0.00335)|Glioma(25;0.08)|all_epithelial(27;0.0992)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(4;1.62e-07)|Lung(4;1.34e-06)|Epithelial(7;0.0107)			ATAGTTCCTTCAAAACCATTG	0.363000													5	82					0	0	1	0	0
RASGRF1	5923	broad.mit.edu	37	15	79296352	79296352	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr15:79296352G>A	ENST00000419573.3	-	16	2563	c.2289C>T	c.(2287-2289)atC>atT	p.I763I	RASGRF1_ENST00000394745.3_5'UTR|RASGRF1_ENST00000558480.2_Silent_p.I747I|RASGRF1_ENST00000560334.1_5'UTR	NM_002891.4	NP_002882.3	Q13972	RGRF1_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 1	764					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(18)|lung(23)|ovary(2)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						CGCCAGTGATGATGGGGATGT	0.652000													4	81					0	0	1	0	0
MUC6	4588	broad.mit.edu	37	11	1031175	1031175	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:1031175C>T	ENST00000421673.2	-	5	618	c.568G>A	c.(568-570)Gag>Aag	p.E190K		NM_005961.2	NP_005952.2	Q6W4X9	MUC6_HUMAN	mucin 6, oligomeric mucus/gel-forming	190	VWFD 1.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(10)|large_intestine(6)|lung(43)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	80		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CTACCCTCCTCACTGACAAAC	0.682000													4	0					0	0	1	0	0
ENPP6	133121	broad.mit.edu	37	4	185038146	185038146	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:185038146C>T	ENST00000296741.2	-	5	859	c.718G>A	c.(718-720)Gat>Aat	p.D240N		NM_153343.3	NP_699174.1	Q6UWR7	ENPP6_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 6	240					lipid catabolic process	extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|skin(2)	15		all_lung(41;7.99e-12)|Lung NSC(41;1.46e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;4.98e-27)|Epithelial(43;3.15e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.09e-12)|Colorectal(24;3.78e-05)|STAD - Stomach adenocarcinoma(60;4.5e-05)|COAD - Colon adenocarcinoma(29;0.000154)|GBM - Glioblastoma multiforme(59;0.000167)|BRCA - Breast invasive adenocarcinoma(30;0.000378)|LUSC - Lung squamous cell carcinoma(40;0.0151)		ATTCCGTGATCCGAGAAAATA	0.532000													20	46					0	0	1	0	0
EDNRB	1910	broad.mit.edu	37	13	78492426	78492426	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr13:78492426C>G	ENST00000377211.4	-	2	705	c.553G>C	c.(553-555)Gag>Cag	p.E185Q	EDNRB_ENST00000446573.1_Missense_Mutation_p.E95Q|EDNRB_ENST00000334286.5_Missense_Mutation_p.E95Q	NM_001201397.1	NP_001188326.1	P24530	EDNRB_HUMAN	endothelin receptor type B	95					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|enteric nervous system development|enteric smooth muscle cell differentiation|macrophage chemotaxis|negative regulation of adenylate cyclase activity|negative regulation of cellular protein metabolic process|negative regulation of neuron maturation|negative regulation of transcription from RNA polymerase II promoter|vein smooth muscle contraction	integral to plasma membrane	endothelin-B receptor activity|peptide hormone binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(18)|lung(16)|skin(3)	42		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0933)	Bosentan(DB00559)	TCCTTGATCTCGATGGGTCCT	0.562000													18	52					0	0	1	0	0
FBXO30	84085	broad.mit.edu	37	6	146127452	146127452	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:146127452C>G	ENST00000237281.4	-	2	256	c.90G>C	c.(88-90)ttG>ttC	p.L30F		NM_032145.4	NP_115521.3	Q8TB52	FBX30_HUMAN	F-box protein 30	30							ubiquitin-protein ligase activity|zinc ion binding			NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26		Ovarian(120;0.0776)		OV - Ovarian serous cystadenocarcinoma(155;1.95e-07)|GBM - Glioblastoma multiforme(68;0.0149)		GACAACCAATCAAATCACAGG	0.463000													4	108					0	0	1	0	0
DENND2A	27147	broad.mit.edu	37	7	140257971	140257971	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:140257971C>T	ENST00000275884.6	-	10	2348	c.1931G>A	c.(1930-1932)aGa>aAa	p.R644K	DENND2A_ENST00000492720.1_Missense_Mutation_p.R644K|DENND2A_ENST00000496613.1_Missense_Mutation_p.R644K|DENND2A_ENST00000537639.1_Missense_Mutation_p.R644K			Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	644	UDENN.									breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(22)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49	Melanoma(164;0.00956)					ACCGAACCTTCTGCTCCCATC	0.468000													38	4					0	0	1	0	0
HIST1H1E	3008	broad.mit.edu	37	6	26157269	26157269	+	Missense_Mutation	SNP	G	G	C	rs139391118	by1000genomes	TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:26157269G>C	ENST00000304218.3	+	1	711	c.651G>C	c.(649-651)aaG>aaC	p.K217N		NM_005321.2	NP_005312.1	P10412	H14_HUMAN	histone cluster 1, H1e	217					nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding	p.K217K(1)		NS(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(1)|liver(1)|lung(9)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	26						CGGCAGCCAAGAAAAAGTAGA	0.537000													40	27					0	0	1	0	0
ARHGAP35	2909	broad.mit.edu	37	19	47492827	47492827	+	Missense_Mutation	SNP	G	G	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:47492827G>T	ENST00000404338.3	+	4	3931	c.3931G>T	c.(3931-3933)Gac>Tac	p.D1311Y		NM_004491.4	NP_004482.4	Q9NRY4	RHG35_HUMAN	Rho GTPase activating protein 35	1311	Rho-GAP.				axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity										GGCAGAGAAAGACTTTACGGT	0.532000													46	38					9.58827e-17	1.02495e-16	1	1	0
WDR96	80217	broad.mit.edu	37	10	105921725	105921725	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr10:105921725C>G	ENST00000357060.3	-	26	3523	c.3408G>C	c.(3406-3408)ttG>ttC	p.L1136F	WDR96_ENST00000428666.1_Missense_Mutation_p.L1137F	NM_025145.5	NP_079421.5	Q8NDM7	WDR96_HUMAN	WD repeat domain 96	1136										NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(14)|lung(21)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						TCACCATTCTCAAAATATCTT	0.423000													16	579					0	0	1	0	0
ARHGEF19	128272	broad.mit.edu	37	1	16534656	16534656	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:16534656G>A	ENST00000270747.3	-	3	613	c.477C>T	c.(475-477)ttC>ttT	p.F159F		NM_153213.3	NP_694945.2	Q8IW93	ARHGJ_HUMAN	Rho guanine nucleotide exchange factor (GEF) 19	159					regulation of actin cytoskeleton organization	intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(1)|lung(3)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	12		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|Colorectal(212;3.48e-07)|COAD - Colon adenocarcinoma(227;2.19e-05)|BRCA - Breast invasive adenocarcinoma(304;9.46e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.0117)|READ - Rectum adenocarcinoma(331;0.0649)		CAGGCTCTAGGAAGACAGCGT	0.662000													46	34					0	0	1	0	0
WDR33	55339	broad.mit.edu	37	2	128467130	128467130	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:128467130G>A	ENST00000322313.4	-	20	3657	c.3499C>T	c.(3499-3501)Cct>Tct	p.P1167S		NM_018383.4	NP_060853.3	Q9C0J8	WDR33_HUMAN	WD repeat domain 33	1167					postreplication repair|spermatogenesis	collagen|nucleus	protein binding			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		AACTCGTCAGGAGTGGGAAGT	0.502000													5	130					0	0	1	0	0
ZNF14	7561	broad.mit.edu	37	19	19822462	19822462	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:19822462G>C	ENST00000344099.3	-	4	1766	c.1628C>G	c.(1627-1629)tCc>tGc	p.S543C		NM_021030.2	NP_066358.2	P17017	ZNF14_HUMAN	zinc finger protein 14	543					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(2)|endometrium(1)|large_intestine(9)|lung(8)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	32		Renal(1328;0.0474)				AATTTGACTGGAACGAAGGAA	0.383000													77	42					0	0	1	0	0
LPHN1	22859	broad.mit.edu	37	19	14262129	14262129	+	Silent	SNP	A	A	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:14262129A>C	ENST00000340736.6	-	24	4278	c.3981T>G	c.(3979-3981)ggT>ggG	p.G1327G	CTB-55O6.12_ENST00000588387.1_RNA|CTB-55O6.12_ENST00000588658.1_RNA|LPHN1_ENST00000361434.3_Silent_p.G1322G	NM_001008701.2	NP_001008701.1	O94910	LPHN1_HUMAN	latrophilin 1	1327					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(3)|liver(1)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						CCCGGTCAGCACCCCCGGGCC	0.716000													7	14					0	0	1	0	0
TMEM38A	79041	broad.mit.edu	37	19	16793300	16793300	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:16793300G>C	ENST00000187762.2	+	4	626	c.535G>C	c.(535-537)Gag>Cag	p.E179Q		NM_024074.1	NP_076979.1	Q9H6F2	TM38A_HUMAN	transmembrane protein 38A	179						integral to membrane|nuclear membrane|sarcoplasmic reticulum membrane	potassium channel activity			central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(1)	15						AGAGACCAACGAGATCCTGCA	0.562000													26	47					0	0	1	0	0
ITIH1	3697	broad.mit.edu	37	3	52823841	52823841	+	Nonsense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:52823841G>A	ENST00000273283.2	+	19	2316	c.2292G>A	c.(2290-2292)tgG>tgA	p.W764*	ITIH1_ENST00000542827.1_3'UTR|ITIH1_ENST00000537050.1_Nonsense_Mutation_p.W476*|ITIH1_ENST00000405128.3_Nonsense_Mutation_p.W130*|ITIH1_ENST00000540715.1_Nonsense_Mutation_p.W622*	NM_002215.3	NP_002206.2	P19827	ITIH1_HUMAN	inter-alpha-trypsin inhibitor heavy chain 1	764	Hyaluronan-binding.				hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(16)|lung(18)|ovary(4)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	52				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		TGTTTTCCTGGAGGGACCAAG	0.622000													51	55					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186076087	186076087	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:186076087G>A	ENST00000271588.4	+	70	11071	c.10842G>A	c.(10840-10842)gtG>gtA	p.V3614V	HMCN1_ENST00000367492.2_Silent_p.V3614V	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	3614	Ig-like C2-type 34.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						AATATCTAGTGAGAGTGCATG	0.388000													5	120					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77618234	77618234	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr8:77618234G>A	ENST00000521891.2	+	2	2359	c.1911G>A	c.(1909-1911)tcG>tcA	p.S637S	ZFHX4_ENST00000455469.2_Silent_p.S637S|ZFHX4_ENST00000517683.1_Intron|ZFHX4_ENST00000518282.1_Silent_p.S637S|ZFHX4_ENST00000050961.6_Silent_p.S637S	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	637						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TGATGCACTCGAGGAACTCAT	0.522000										HNSCC(33;0.089)			28	80					0	0	1	0	0
BCAR1	9564	broad.mit.edu	37	16	75276443	75276443	+	Silent	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr16:75276443C>G	ENST00000546196.1	-	2	2123	c.471G>C	c.(469-471)ggG>ggC	p.G157G	BCAR1_ENST00000162330.5_Silent_p.G186G|BCAR1_ENST00000418647.3_Silent_p.G232G|BCAR1_ENST00000535626.2_Intron|BCAR1_ENST00000393422.2_Silent_p.G204G|BCAR1_ENST00000542031.2_Silent_p.G184G|BCAR1_ENST00000420641.3_Silent_p.G204G|BCAR1_ENST00000393420.6_Silent_p.G186G|BCAR1_ENST00000538440.2_Silent_p.G186G			P56945	BCAR1_HUMAN	breast cancer anti-estrogen resistance 1	186	Substrate for kinases (By similarity).				actin filament organization|B cell receptor signaling pathway|blood coagulation|cell adhesion|cell division|cell migration|cell proliferation|epidermal growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|integrin-mediated signaling pathway|nerve growth factor receptor signaling pathway|platelet-derived growth factor receptor signaling pathway|positive regulation of cell migration|regulation of apoptosis|regulation of cell growth|T cell receptor signaling pathway	cytosol|focal adhesion|membrane fraction|ruffle	protein kinase binding|protein phosphatase binding|SH3 domain binding|signal transducer activity			breast(2)|central_nervous_system(5)|endometrium(1)|kidney(6)|large_intestine(1)|liver(1)|lung(13)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)	35				BRCA - Breast invasive adenocarcinoma(221;0.169)		CATGCCCCATCCCGGCAGAAG	0.652000													13	113					0	0	1	0	0
FAM3C	10447	broad.mit.edu	37	7	121012180	121012180	+	Missense_Mutation	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:121012180C>A	ENST00000359943.3	-	4	345	c.132G>T	c.(130-132)ttG>ttT	p.L44F		NM_001040020.1|NM_014888.2	NP_001035109.1|NP_055703.1	Q92520	FAM3C_HUMAN	family with sequence similarity 3, member C	44					multicellular organismal development	cytoplasmic membrane-bounded vesicle|extracellular region	cytokine activity			kidney(1)|lung(8)	9	all_neural(327;0.117)					CAGCTGTGTCCAATGCTGATC	0.308000													13	5					1.15088e-07	1.2026e-07	1	1	0
GRAMD1C	54762	broad.mit.edu	37	3	113595078	113595078	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:113595078G>A	ENST00000358160.4	+	5	922	c.430G>A	c.(430-432)Gct>Act	p.A144T	GRAMD1C_ENST00000452134.2_5'UTR|GRAMD1C_ENST00000479212.1_3'UTR	NM_017577.4	NP_060047.3	Q8IYS0	GRM1C_HUMAN	GRAM domain containing 1C	144						integral to membrane				NS(1)|endometrium(1)|large_intestine(6)|lung(13)|ovary(2)|skin(3)	26						CATCCCAAACGCTATCCAGAT	0.299000													6	130					0	0	1	0	0
ARFGEF2	10564	broad.mit.edu	37	20	47587686	47587686	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr20:47587686C>T	ENST00000371917.4	+	10	1220	c.1220C>T	c.(1219-1221)tCc>tTc	p.S407F		NM_006420.2	NP_006411.2	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)	407					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(7)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	63			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			AAGGTGGTTTCCCTGCAGCTG	0.448000													5	179					0	0	1	0	0
NPR3	4883	broad.mit.edu	37	5	32712192	32712192	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:32712192G>A	ENST00000265074.8	+	1	653	c.310G>A	c.(310-312)Gag>Aag	p.E104K	NPR3_ENST00000415685.2_Intron|NPR3_ENST00000415167.2_Missense_Mutation_p.E104K|NPR3_ENST00000434067.2_Intron	NM_000908.3|NM_001204375.1	NP_000899.1|NP_001191304.1	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)	104					osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	24					Nesiritide(DB04899)	GGTGGCTTACGAGGATTCAGA	0.692000													59	128					0	0	1	0	0
ARHGEF40	55701	broad.mit.edu	37	14	21553959	21553959	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr14:21553959G>C	ENST00000298694.4	+	19	4199	c.4072G>C	c.(4072-4074)Gag>Cag	p.E1358Q	ARHGEF40_ENST00000298693.3_Missense_Mutation_p.E1358Q			Q8TER5	ARH40_HUMAN	Rho guanine nucleotide exchange factor (GEF) 40	1358	PH.				regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(4)|ovary(3)|upper_aerodigestive_tract(2)	9						AACCTCACCAGAGATCAAACT	0.577000													3	33					0	0	1	0	0
NKAPL	222698	broad.mit.edu	37	6	28227839	28227839	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:28227839G>A	ENST00000343684.3	+	1	742	c.690G>A	c.(688-690)aaG>aaA	p.K230K		NM_001007531.1	NP_001007532.1	Q5M9Q1	NKAPL_HUMAN	NFKB activating protein-like	230	Lys-rich.									breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	31						agaaaaagaagaaaaagaaac	0.338000													13	16					0	0	1	0	0
SOCS2	8835	broad.mit.edu	37	12	93968538	93968538	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:93968538G>A	ENST00000340600.2	+	3	778	c.180G>A	c.(178-180)gaG>gaA	p.E60E	SOCS2_ENST00000536696.2_Silent_p.E60E|SOCS2_ENST00000549206.1_Silent_p.E60E|SOCS2_ENST00000551556.1_Silent_p.E60E|SOCS2_ENST00000549122.1_Silent_p.E60E|SOCS2_ENST00000548537.1_3'UTR	NM_001270468.1|NM_001270469.1|NM_001270471.1|NM_003877.4	NP_001257397.1|NP_001257398.1|NP_001257400.1|NP_003868.1	O14508	SOCS2_HUMAN	suppressor of cytokine signaling 2	60	SH2.				anti-apoptosis|growth hormone receptor signaling pathway|JAK-STAT cascade|negative regulation of signal transduction|regulation of cell growth|response to estradiol stimulus	cytoplasm	growth hormone receptor binding|insulin-like growth factor receptor binding|JAK pathway signal transduction adaptor activity|prolactin receptor binding|SH3/SH2 adaptor activity			cervix(1)|endometrium(3)|large_intestine(3)|lung(6)|ovary(1)	14						AAGCCAAAGAGAAATTAAAAG	0.358000													4	66					0	0	1	0	0
GRB10	2887	broad.mit.edu	37	7	50673017	50673017	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:50673017G>A	ENST00000403097.1	-	14	2121	c.1341C>T	c.(1339-1341)agC>agT	p.S447S	GRB10_ENST00000439599.1_Silent_p.S447S|GRB10_ENST00000398810.2_Silent_p.S395S|GRB10_ENST00000401949.1_Silent_p.S453S|GRB10_ENST00000398812.2_Silent_p.S453S|GRB10_ENST00000402497.1_Silent_p.S395S|GRB10_ENST00000402578.1_Silent_p.S395S|GRB10_ENST00000357271.5_Silent_p.S407S|GRB10_ENST00000335866.3_Silent_p.S395S|GRB10_ENST00000407526.1_Silent_p.S395S|GRB10_ENST00000406641.1_Silent_p.S395S			Q13322	GRB10_HUMAN	growth factor receptor-bound protein 10	453					insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway	cytosol|plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity			NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(19)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	41	Glioma(55;0.08)|all_neural(89;0.245)					CCAGGGCTGCGCTCTGGGCCT	0.637000									Russell-Silver syndrome				16	69					0	0	1	0	0
MAT2A	4144	broad.mit.edu	37	2	85770092	85770092	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:85770092G>C	ENST00000306434.3	+	8	1143	c.1020G>C	c.(1018-1020)aaG>aaC	p.K340N	MAT2A_ENST00000409017.1_Missense_Mutation_p.K277N	NM_005911.5	NP_005902.1	P31153	METK2_HUMAN	methionine adenosyltransferase II, alpha	340					methylation|xenobiotic metabolic process	cytosol	ATP binding|metal ion binding|methionine adenosyltransferase activity			breast(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	9					L-Methionine(DB00134)|S-Adenosylmethionine(DB00118)	CCTCTCAGAAGAGTGAGAGAG	0.398000													21	61					0	0	1	0	0
FGA	2243	broad.mit.edu	37	4	155507643	155507643	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:155507643G>C	ENST00000302053.3	-	5	1016	c.938C>G	c.(937-939)tCt>tGt	p.S313C	FGA_ENST00000403106.3_Missense_Mutation_p.S313C	NM_000508.3	NP_000499.1	P02671	FIBA_HUMAN	fibrinogen alpha chain	313					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	73	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	TCCAGTCCCAGAGCTCCCAGG	0.572000													124	137					0	0	1	0	0
DMXL1	1657	broad.mit.edu	37	5	118505897	118505897	+	Nonsense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:118505897C>G	ENST00000311085.8	+	24	5491	c.5411C>G	c.(5410-5412)tCa>tGa	p.S1804*	DMXL1_ENST00000539542.1_Nonsense_Mutation_p.S1804*	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	1804										breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		CAAGTTTTATCAGCCAGTAAT	0.323000													27	15					0	0	1	0	0
ZNF100	163227	broad.mit.edu	37	19	21909601	21909601	+	Missense_Mutation	SNP	T	T	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:21909601T>C	ENST00000358296.6	-	5	1711	c.1513A>G	c.(1513-1515)Ata>Gta	p.I505V	ZNF100_ENST00000305570.6_Missense_Mutation_p.I441V	NM_173531.3	NP_775802.2	Q8IYN0	ZN100_HUMAN	zinc finger protein 100	505					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(11)|skin(1)|upper_aerodigestive_tract(1)	21						GTATGAGTTATCTTATGTTTA	0.368000													43	40					0	0	1	0	0
ADAM29	11086	broad.mit.edu	37	4	175897229	175897229	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:175897229C>G	ENST00000359240.3	+	5	1223	c.553C>G	c.(553-555)Cag>Gag	p.Q185E	ADAM29_ENST00000445694.1_Missense_Mutation_p.Q185E|ADAM29_ENST00000404450.4_Missense_Mutation_p.Q185E|ADAM29_ENST00000514159.1_Missense_Mutation_p.Q185E	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	185					proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding	p.Q185E(1)		NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		TAATTCCACTCAGAAGCAAAG	0.358000													38	44					0	0	1	0	0
POTEC	388468	broad.mit.edu	37	18	14542973	14542973	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr18:14542973C>T	ENST00000358970.5	-	1	172	c.173G>A	c.(172-174)aGg>aAg	p.R58K	POTEC_ENST00000389891.4_5'UTR	NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	58										NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						CATCTTGCTCCTGAGCATCTT	0.582000													66	197					0	0	1	0	0
ACBD4	79777	broad.mit.edu	37	17	43220960	43220960	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:43220960C>T	ENST00000592162.1	+	9	1101	c.800C>T	c.(799-801)gCa>gTa	p.A267V	ACBD4_ENST00000591859.1_Silent_p.C326C|ACBD4_ENST00000321854.8_3'UTR|ACBD4_ENST00000431281.1_Silent_p.C326C|ACBD4_ENST00000586346.1_Silent_p.C326C|ACBD4_ENST00000398322.3_3'UTR			Q8NC06	ACBD4_HUMAN	acyl-CoA binding domain containing 4	0							fatty-acyl-CoA binding			kidney(1)|lung(3)|ovary(1)	5						GGGGTCTCTGCAGCCAACTGA	0.557000													50	30					0	0	1	0	0
TSPYL1	7259	broad.mit.edu	37	6	116600642	116600642	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:116600642C>T	ENST00000368608.3	-	1	424	c.352G>A	c.(352-354)Gac>Aac	p.D118N	DSE_ENST00000540275.1_Intron	NM_003309.3	NP_003300.1	Q9H0U9	TSYL1_HUMAN	TSPY-like 1	118					nucleosome assembly	nucleolus				breast(1)|endometrium(2)|large_intestine(2)|lung(2)|ovary(3)|urinary_tract(1)	11		all_cancers(87;0.0144)|all_epithelial(87;0.021)|Colorectal(196;0.234)		all cancers(137;0.0235)|OV - Ovarian serous cystadenocarcinoma(136;0.0469)|GBM - Glioblastoma multiforme(226;0.0503)|Epithelial(106;0.094)		AGGCTGCGGTCGGCTGCCATC	0.657000													59	42					0	0	1	0	0
TMEM175	84286	broad.mit.edu	37	4	951666	951666	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:951666C>T	ENST00000264771.4	+	11	1082	c.897C>T	c.(895-897)ctC>ctT	p.L299L	TMEM175_ENST00000508204.1_Silent_p.L217L|TMEM175_ENST00000515740.1_Silent_p.L183L	NM_032326.2	NP_115702.1	Q9BSA9	TM175_HUMAN	transmembrane protein 175	299						integral to membrane		p.L299L(1)		NS(1)|endometrium(1)|large_intestine(2)|lung(6)|pancreas(1)|upper_aerodigestive_tract(3)	14			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			GCGGCAGCCTCGTGGCCGCCC	0.632000													59	91					0	0	1	0	0
PCDHGA9	56107	broad.mit.edu	37	5	140782700	140782700	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:140782700G>C	ENST00000573521.1	+	1	181	c.181G>C	c.(181-183)Gag>Cag	p.E61Q	PCDHGA4_ENST00000571252.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA8_ENST00000398604.2_Intron	NM_018921.2|NM_032089.1	NP_061744.1|NP_114478.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGAGCTGGCGGAGCGCCGAGT	0.607000													52	108					0	0	1	0	0
C2orf44	80304	broad.mit.edu	37	2	24260579	24260579	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:24260579G>C	ENST00000295148.4	-	2	1843	c.1786C>G	c.(1786-1788)Caa>Gaa	p.Q596E	C2orf44_ENST00000406895.3_Missense_Mutation_p.Q596E	NM_025203.2	NP_079479.1	Q9H6R7	CB044_HUMAN	chromosome 2 open reading frame 44	596							protein binding	p.Q596E(1)	C2orf44/ALK(2)	breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(7)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	24	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGAAGATCTTGAGAGAGTGGA	0.403000			T	ALK	NSCLC								89	50					0	0	1	0	0
TTYH2	94015	broad.mit.edu	37	17	72233568	72233568	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:72233568C>G	ENST00000269346.4	+	4	624	c.550C>G	c.(550-552)Cag>Gag	p.Q184E	TTYH2_ENST00000529107.1_Missense_Mutation_p.Q163E	NM_032646.5	NP_116035.5	Q9BSA4	TTYH2_HUMAN	tweety family member 2	184						chloride channel complex|plasma membrane	chloride channel activity|protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(14)|ovary(3)|pancreas(1)|stomach(3)|upper_aerodigestive_tract(1)	36						CGTTGTTGTTCAGCTCTCAGG	0.597000													21	50					0	0	1	0	0
ZNF331	55422	broad.mit.edu	37	19	54081027	54081027	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:54081027C>T	ENST00000253144.9	+	7	2546	c.1213C>T	c.(1213-1215)Cat>Tat	p.H405Y	ZNF331_ENST00000511154.1_Missense_Mutation_p.H405Y|ZNF331_ENST00000511593.2_Missense_Mutation_p.H405Y|ZNF331_ENST00000513999.1_Missense_Mutation_p.H405Y|ZNF331_ENST00000512387.1_Missense_Mutation_p.H405Y|ZNF331_ENST00000411977.2_Missense_Mutation_p.H405Y|ZNF331_ENST00000449416.1_Missense_Mutation_p.H405Y	NM_001253801.1|NM_018555.5	NP_001240730.1|NP_061025.5	Q9NQX6	ZN331_HUMAN	zinc finger protein 331	405					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|large_intestine(1)|lung(1)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	10				GBM - Glioblastoma multiforme(134;0.00555)		TGAGAGAATTCATACCGGGGT	0.483000			T	?	follicular thyroid adenoma								28	22					0	0	1	0	0
GGT1	2678	broad.mit.edu	37	22	25016298	25016298	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr22:25016298G>A	ENST00000400382.1	+	8	1141	c.386G>A	c.(385-387)gGg>gAg	p.G129E	GGT1_ENST00000400380.1_Missense_Mutation_p.G129E|GGT1_ENST00000400383.1_Missense_Mutation_p.G129E|GGT1_ENST00000248923.4_Missense_Mutation_p.G129E|GGT1_ENST00000406383.2_Missense_Mutation_p.G129E			P19440	GGT1_HUMAN	gamma-glutamyltransferase 1	129					glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity|protein binding			breast(1)|endometrium(2)|kidney(14)|large_intestine(2)|lung(6)|pancreas(1)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	40					Glutathione(DB00143)	TCCCCAGGGGGGCTGTCGGTG	0.642000													10	23					0	0	1	0	0
KIZ-AS1	101929591	broad.mit.edu	37	20	21143479	21143479	+	RNA	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr20:21143479C>T	ENST00000591761.1	-	0	5099				RP5-872K7.7_ENST00000425746.2_RNA|PLK1S1_ENST00000457464.1_RNA																							CAGTTCATGTCGCCACTTGCA	0.458000													13	16					0	0	1	0	0
PTGR2	145482	broad.mit.edu	37	14	74347981	74347981	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr14:74347981G>C	ENST00000555661.1	+	8	1070	c.925G>C	c.(925-927)Gaa>Caa	p.E309Q	RP5-1021I20.4_ENST00000556551.2_Missense_Mutation_p.E239Q|PTGR2_ENST00000553813.1_Missense_Mutation_p.E175Q|PTGR2_ENST00000555228.1_Missense_Mutation_p.E309Q|PTGR2_ENST00000267568.4_Missense_Mutation_p.E309Q			Q8N8N7	PTGR2_HUMAN	prostaglandin reductase 2	309					prostaglandin metabolic process		15-oxoprostaglandin 13-oxidase activity|zinc ion binding			NS(1)|large_intestine(3)|lung(2)|prostate(1)|skin(2)	9						GTGGTTTAAAGAAGGAAAGCT	0.313000													48	16					0	0	1	0	0
ZNF350	59348	broad.mit.edu	37	19	52469258	52469258	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr19:52469258C>T	ENST00000243644.4	-	5	675	c.448G>A	c.(448-450)Gaa>Aaa	p.E150K	HCCAT3_ENST00000595010.1_RNA|HCCAT3_ENST00000600253.1_RNA	NM_021632.3	NP_067645.3	Q9GZX5	ZN350_HUMAN	zinc finger protein 350	150					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix|transcriptional repressor complex	DNA binding|protein binding|zinc ion binding			breast(4)|endometrium(3)|kidney(3)|large_intestine(7)|lung(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26		all_neural(266;0.0505)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0179)		TTCTTTATTTCATAGCCTTTG	0.348000													71	44					0	0	1	0	0
EFCAB5	374786	broad.mit.edu	37	17	28296332	28296332	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:28296332G>A	ENST00000394835.3	+	4	906	c.714G>A	c.(712-714)atG>atA	p.M238I	EFCAB5_ENST00000536908.2_Missense_Mutation_p.M182I|EFCAB5_ENST00000320856.5_Missense_Mutation_p.M238I|EFCAB5_ENST00000541045.1_Intron|EFCAB5_ENST00000378738.3_Missense_Mutation_p.M238I|EFCAB5_ENST00000394832.2_Missense_Mutation_p.M238I|EFCAB5_ENST00000534836.2_Intron	NM_198529.3	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5	238							calcium ion binding	p.M238I(1)		breast(7)|endometrium(2)|kidney(4)|large_intestine(11)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	43						AGAGGTTGATGAAAGAAGTCA	0.358000													21	27					0	0	1	0	0
SREK1	140890	broad.mit.edu	37	5	65460643	65460643	+	Nonsense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:65460643C>T	ENST00000334121.6	+	7	1078	c.919C>T	c.(919-921)Cga>Tga	p.R307*	SREK1_ENST00000380918.3_Nonsense_Mutation_p.R191*|SREK1_ENST00000284041.3_3'UTR	NM_001077199.2|NM_001270492.1	NP_001070667.1|NP_001257421.1	Q8WXA9	SREK1_HUMAN	splicing regulatory glutamine/lysine-rich protein 1	191	Arg/Glu/Lys/Ser-rich.				mRNA processing|RNA splicing	spliceosomal complex	nucleic acid binding|nucleotide binding|protein binding			breast(1)|kidney(3)|large_intestine(2)|lung(1)|pancreas(1)|prostate(1)	9						AAAAGGCGGTCGATCTCGTTC	0.413000													39	94					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228486995	228486995	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:228486995G>A	ENST00000570156.2	+	50	13320	c.13246G>A	c.(13246-13248)Gaa>Aaa	p.E4416K	OBSCN_ENST00000359599.6_3'UTR|OBSCN_ENST00000422127.1_Intron|RP5-1139B12.4_ENST00000602778.1_RNA|OBSCN_ENST00000366709.4_Intron|OBSCN_ENST00000284548.11_Intron|OBSCN_ENST00000366707.4_Missense_Mutation_p.E1106K	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	3459	Ig-like 45.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				TCTGAGGAATGAAGAGGCCAT	0.557000													6	84					0	0	1	0	0
PPIB	5479	broad.mit.edu	37	15	64454344	64454344	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr15:64454344C>G	ENST00000300026.3	-	2	363	c.145G>C	c.(145-147)Gac>Cac	p.D49H	PPIB_ENST00000558492.1_Intron	NM_000942.4	NP_000933.1	P23284	PPIB_HUMAN	peptidylprolyl isomerase B (cyclophilin B)	49	PPIase cyclophilin-type.				protein folding	endoplasmic reticulum lumen|melanosome	peptide binding|peptidyl-prolyl cis-trans isomerase activity|unfolded protein binding			kidney(2)|large_intestine(2)|lung(6)	10					L-Proline(DB00172)	ATTCGTAGGTCAAAATACACC	0.463000													149	114					0	0	1	0	0
P2RX6	9127	broad.mit.edu	37	22	21377687	21377687	+	Silent	SNP	C	C	T	rs147788586	byFrequency	TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr22:21377687C>T	ENST00000413302.2	+	7	910	c.762C>T	c.(760-762)ttC>ttT	p.F254F	P2RX6_ENST00000402329.3_3'UTR|P2RX6_ENST00000443995.3_Silent_p.F201F|P2RX6_ENST00000336296.2_Silent_p.F244F|P2RX6_ENST00000401443.1_Silent_p.F228F			O15547	P2RX6_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 6	254					muscle contraction|protein homooligomerization	cell junction|cytoplasm|integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|identical protein binding|purinergic nucleotide receptor activity										GAGGGACCTTCGAGGACCTGG	0.617000													25	48					0	0	1	0	0
TSC2	7249	broad.mit.edu	37	16	2098649	2098649	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr16:2098649G>A	ENST00000219476.3	+	2	663	c.33G>A	c.(31-33)ttG>ttA	p.L11L	TSC2_ENST00000350773.4_Silent_p.L11L|TSC2_ENST00000439673.2_Silent_p.L11L|TSC2_ENST00000568454.1_Silent_p.L22L|TSC2_ENST00000353929.4_Silent_p.L11L|TSC2_ENST00000401874.2_Silent_p.L11L|TSC2_ENST00000382538.6_Intron	NM_000548.3	NP_000539.2	P49815	TSC2_HUMAN	tuberous sclerosis 2	11	Required for interaction with TSC1.				cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(3)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|soft_tissue(1)	56		Hepatocellular(780;0.0202)				ATTCAGGCTTGAAGGAGAAGT	0.502000			"""D, Mis, N, F, S"""			"""hamartoma, renal cell"""			Tuberous Sclerosis				24	47					0	0	1	0	0
ZNF786	136051	broad.mit.edu	37	7	148767620	148767620	+	Silent	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:148767620C>A	ENST00000316286.9	-	3	2258	c.1986G>T	c.(1984-1986)gcG>gcT	p.A662A	ZNF786_ENST00000491431.1_Silent_p.A748A|ZNF786_ENST00000451334.3_Silent_p.A711A			Q8N393	ZN786_HUMAN	zinc finger protein 786	748					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|cervix(1)|kidney(1)|large_intestine(3)|lung(10)|prostate(2)|skin(2)|soft_tissue(1)|urinary_tract(2)	26	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			TGATGTGCTCCGCAAGCTTAG	0.512000													9	124					3.09899e-07	3.22739e-07	1	1	0
NF1	4763	broad.mit.edu	37	17	29559126	29559126	+	Nonsense_Mutation	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr17:29559126C>A	ENST00000358273.4	+	25	3616	c.3233C>A	c.(3232-3234)tCa>tAa	p.S1078*	NF1_ENST00000356175.3_Nonsense_Mutation_p.S1078*	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	1078					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(4)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		GCAGTAGTTTCACTTCTAGCT	0.363000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			22	18					4.35082e-09	4.5876e-09	1	1	0
TCHP	84260	broad.mit.edu	37	12	110353227	110353227	+	Missense_Mutation	SNP	A	A	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:110353227A>C	ENST00000312777.5	+	12	1554	c.1340A>C	c.(1339-1341)cAg>cCg	p.Q447P	TCHP_ENST00000405876.4_Missense_Mutation_p.Q447P	NM_032300.4	NP_115676.1	Q9BT92	TCHP_HUMAN	trichoplein, keratin filament binding	447	Glu-rich.|Interaction with keratin proteins.				apoptosis|negative regulation of cell growth	apical cortex|centrosome|keratin filament|mitochondrion|plasma membrane	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|ovary(1)|skin(2)	22						CGCCGGCTGCAGGCATGGGAA	0.637000													20	55					0	0	1	0	0
DCT	1638	broad.mit.edu	37	13	95092235	95092235	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr13:95092235G>C	ENST00000377028.5	-	8	1890	c.1477C>G	c.(1477-1479)Ctt>Gtt	p.L493V	DCT_ENST00000446125.1_Missense_Mutation_p.L526V	NM_001922.3	NP_001913.2	P40126	TYRP2_HUMAN	dopachrome tautomerase	493					epidermis development|melanin biosynthetic process from tyrosine	cytosol|integral to membrane|melanosome membrane|microsome	copper ion binding|dopachrome isomerase activity|oxidoreductase activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	50	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;3.71e-42)|all_epithelial(2;3.76e-31)|all_lung(2;5.16e-14)|Lung NSC(4;1.33e-13)|Breast(118;0.0013)|Hepatocellular(115;0.00886)|Renal(2;0.00988)		COAD - Colon adenocarcinoma(199;7.07e-05)|GBM - Glioblastoma multiforme(99;0.000472)		CTATATTGAAGAAAAGCCAAC	0.433000													14	51					0	0	1	0	0
CDHR3	222256	broad.mit.edu	37	7	105662837	105662837	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:105662837G>A	ENST00000542731.1	+	14	2127	c.2019G>A	c.(2017-2019)gtG>gtA	p.V673V	CDHR3_ENST00000478080.1_Silent_p.V585V|CDHR3_ENST00000343407.5_Intron|CDHR3_ENST00000317716.9_Silent_p.V673V|CDHR3_ENST00000470188.1_Intron			Q6ZTQ4	CDHR3_HUMAN	cadherin-related family member 3	673	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|cervix(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(15)|ovary(1)	23						CAGGAACAGTGACACTGAGTA	0.483000													113	26					0	0	1	0	0
PAG1	55824	broad.mit.edu	37	8	81897370	81897370	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr8:81897370C>T	ENST00000220597.4	-	7	1227	c.517G>A	c.(517-519)Gaa>Aaa	p.E173K		NM_018440.3	NP_060910.3	Q9NWQ8	PAG1_HUMAN	phosphoprotein associated with glycosphingolipid microdomains 1	173					epidermal growth factor receptor signaling pathway|intracellular signal transduction|T cell receptor signaling pathway	integral to membrane|intracellular|membrane raft|plasma membrane	SH2 domain binding|SH3/SH2 adaptor activity			breast(2)|cervix(1)|endometrium(1)|large_intestine(3)|lung(2)|prostate(2)	11	Lung NSC(7;5.76e-06)|all_lung(9;2e-05)		BRCA - Breast invasive adenocarcinoma(6;0.0567)|Epithelial(68;0.0634)|all cancers(69;0.197)			ACCATGTTTTCTTGGGAGGAG	0.562000													4	149					0	0	1	0	0
INPPL1	3636	broad.mit.edu	37	11	71948716	71948716	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:71948716C>T	ENST00000541756.1	+	26	3632	c.2702C>T	c.(2701-2703)tCa>tTa	p.S901L	INPPL1_ENST00000298229.2_Missense_Mutation_p.S1143L|INPPL1_ENST00000538751.1_Missense_Mutation_p.S901L			O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	1143					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						CCTGCACGCTCAGCGCTCCTC	0.711000													28	25					0	0	1	0	0
MCM9	254394	broad.mit.edu	37	6	119245037	119245037	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:119245037G>A	ENST00000316316.6	-	3	846	c.560C>T	c.(559-561)tCa>tTa	p.S187L	MCM9_ENST00000316068.3_Missense_Mutation_p.S187L	NM_017696.2	NP_060166.2	Q9NXL9	MCM9_HUMAN	minichromosome maintenance complex component 9	187					DNA replication		ATP binding|DNA binding|nucleoside-triphosphatase activity	p.S187*(2)		cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		all_cancers(87;0.122)|all_epithelial(87;0.179)		GBM - Glioblastoma multiforme(226;0.0676)|OV - Ovarian serous cystadenocarcinoma(136;0.194)		AGACAAGCCTGAGAGGCAAGT	0.418000													17	42					0	0	1	0	0
NUP210P1	255330	broad.mit.edu	37	3	126382219	126382219	+	RNA	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:126382219C>G	ENST00000357061.3	+	0	186					NR_034158.1																						ATCCTTTTCTCCATCAGCAAC	0.582000													30	22					0	0	1	0	0
TSSC2	650368	broad.mit.edu	37	11	3427845	3427845	+	RNA	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:3427845C>T	ENST00000529482.1	+	0	962																											CTTCAAGTGGCAGGAGCAGAA	0.587000													6	37					0	0	1	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33576272	33576272	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:33576272C>G	ENST00000504830.1	-	19	4194	c.3859G>C	c.(3859-3861)Gag>Cag	p.E1287Q	ADAMTS12_ENST00000352040.3_Missense_Mutation_p.E1202Q	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	1287	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						GCATCCTCCTCAGTCAGGACT	0.493000										HNSCC(64;0.19)			12	491					0	0	1	0	0
PRPF18	8559	broad.mit.edu	37	10	13653625	13653625	+	Missense_Mutation	SNP	A	A	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr10:13653625A>G	ENST00000378572.3	+	6	681	c.521A>G	c.(520-522)gAg>gGg	p.E174G		NM_003675.3	NP_003666.1	Q99633	PRP18_HUMAN	pre-mRNA processing factor 18	174					mRNA processing|RNA splicing	nuclear speck|spliceosomal complex				central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(5)|prostate(1)	17						GCGCTTGGAGAGTCCTTAGGG	0.428000													54	56					0	0	1	0	0
PIM1	5292	broad.mit.edu	37	6	37138635	37138635	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:37138635C>T	ENST00000373509.5	+	2	542	c.169C>T	c.(169-171)Cgc>Tgc	p.R57C		NM_001243186.1|NM_002648.3	NP_001230115.1|NP_002639.1	P11309	PIM1_HUMAN	pim-1 oncogene	148					cell cycle|cell proliferation|multicellular organismal development|negative regulation of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|protein autophosphorylation	cytoplasm|nucleus|plasma membrane	ATP binding|manganese ion binding|protein binding|protein serine/threonine kinase activity|transcription factor binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(17)|large_intestine(4)|lung(3)|prostate(2)|skin(2)	30			OV - Ovarian serous cystadenocarcinoma(102;0.241)		Adenosine monophosphate(DB00131)	CTCAGGCATCCGCGTCTCCGA	0.716000			T	BCL6	NHL								16	53					0	0	1	0	0
MAPK10	5602	broad.mit.edu	37	4	87023066	87023066	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:87023066G>A	ENST00000395169.3	-	7	1151	c.431C>T	c.(430-432)tCt>tTt	p.S144F	MAPK10_ENST00000361569.2_Missense_Mutation_p.S182F|MAPK10_ENST00000395166.1_Missense_Mutation_p.S144F|MAPK10_ENST00000449047.2_Missense_Mutation_p.S37F|MAPK10_ENST00000395160.3_Missense_Mutation_p.S37F|MAPK10_ENST00000395157.3_Missense_Mutation_p.S37F|MAPK10_ENST00000359221.3_Missense_Mutation_p.S182F|MAPK10_ENST00000395161.2_Missense_Mutation_p.S182F	NM_138980.2|NM_138982.2	NP_620446.1|NP_620448.1	P53779	MK10_HUMAN	mitogen-activated protein kinase 10	182	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|MAP kinase kinase activity|protein binding			breast(1)|central_nervous_system(1)|stomach(1)	3		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.243)		OV - Ovarian serous cystadenocarcinoma(123;0.002)		AATTCCAGCAGAATGGAGGTG	0.398000													77	79					0	0	1	0	0
PLEKHM2	23207	broad.mit.edu	37	1	16051906	16051906	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:16051906G>C	ENST00000375799.3	+	8	1034	c.807G>C	c.(805-807)caG>caC	p.Q269H	RP11-288I21.1_ENST00000453804.1_RNA|PLEKHM2_ENST00000375793.2_Missense_Mutation_p.Q249H	NM_015164.2	NP_055979.2	Q8IWE5	PKHM2_HUMAN	pleckstrin homology domain containing, family M (with RUN domain) member 2	269	Interaction with KIF5B.				Golgi organization	cytoplasm	kinesin binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	12		Colorectal(325;0.000259)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00057)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		CCCAGCGCCAGAACCCCTTCA	0.662000													4	4					0	0	1	0	0
COL4A3	1285	broad.mit.edu	37	2	228163451	228163451	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:228163451G>C	ENST00000396578.3	+	43	3967	c.3805G>C	c.(3805-3807)Gac>Cac	p.D1269H	AC097662.2_ENST00000433324.1_RNA|COL4A3_ENST00000468753.1_3'UTR|AC097662.2_ENST00000396588.2_RNA|AC097662.2_ENST00000439598.2_RNA	NM_000091.4	NP_000082.2	Q01955	CO4A3_HUMAN	collagen, type IV, alpha 3 (Goodpasture antigen)	1269	Triple-helical region.		D -> E (in dbSNP:rs57611801).		activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		CATAAAAGGAGACAAAGGGTC	0.522000													19	26					0	0	1	0	0
WDR17	116966	broad.mit.edu	37	4	177083305	177083305	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:177083305C>T	ENST00000393643.2	+	21	3082	c.2830C>T	c.(2830-2832)Ctt>Ttt	p.L944F	WDR17_ENST00000280190.4_Missense_Mutation_p.L968F|WDR17_ENST00000508596.1_Missense_Mutation_p.L944F|WDR17_ENST00000507824.2_Missense_Mutation_p.L951F	NM_170710.4	NP_733828.2	Q8IZU2	WDR17_HUMAN	WD repeat domain 17	968										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(18)|lung(46)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	92		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		ATGTTGCCATCTTGCCATAGA	0.363000													27	31					0	0	1	0	0
SP110	3431	broad.mit.edu	37	2	231076216	231076216	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr2:231076216C>T	ENST00000258381.6	-	6	797	c.720G>A	c.(718-720)gaG>gaA	p.E240E	SP110_ENST00000486146.2_5'UTR|SP110_ENST00000258382.5_Silent_p.E240E|SP110_ENST00000540870.1_Silent_p.E246E|SP110_ENST00000358662.4_Silent_p.E240E|SP110_ENST00000392048.3_Silent_p.E240E|SP110_ENST00000338556.3_5'UTR	NM_080424.2	NP_536349	Q9HB58	SP110_HUMAN	SP110 nuclear body protein	240					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|signal transducer activity|zinc ion binding			breast(4)|endometrium(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Renal(207;0.0112)|all_lung(227;0.0223)|Lung NSC(271;0.0983)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.169)		Epithelial(121;2.61e-12)|all cancers(144;6.39e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.0097)		AGTGGGGCATCTCTTGAGGGT	0.458000													22	30					0	0	1	0	0
VNN3	55350	broad.mit.edu	37	6	133045826	133045826	+	Missense_Mutation	SNP	C	C	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr6:133045826C>A	ENST00000207771.3	-	6	1191	c.1119G>T	c.(1117-1119)atG>atT	p.M373I	VNN3_ENST00000392393.3_3'UTR|VNN3_ENST00000275223.3_3'UTR|VNN3_ENST00000509351.1_3'UTR|VNN3_ENST00000519686.2_3'UTR|VNN3_ENST00000414302.2_3'UTR|VNN3_ENST00000427187.2_3'UTR|VNN3_ENST00000367927.5_3'UTR|VNN3_ENST00000425515.2_3'UTR|VNN3_ENST00000423615.2_3'UTR|VNN3_ENST00000417437.2_3'UTR					vanin 3											cervix(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(1)|stomach(1)	8	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00242)|GBM - Glioblastoma multiforme(226;0.0168)		GCTTCTCAGACATCTTGTAAG	0.383000													13	13					0.00136819	0.00138007	1	1	0
MALAT1	378938	broad.mit.edu	37	11	65266183	65266183	+	RNA	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:65266183G>A	ENST00000534336.1	+	0	951					NR_002819.2																						TCCCTCAAGAGAACACAAGAA	0.393000													6	209					0	0	1	0	0
HMX1	3166	broad.mit.edu	37	4	8869772	8869772	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:8869772C>T	ENST00000400677.3	-	2	896	c.694G>A	c.(694-696)Gag>Aag	p.E232K	HMX1_ENST00000506970.2_Intron	NM_018942.2	NP_061815.2	Q9NP08	HMX1_HUMAN	H6 family homeobox 1	232					multicellular organismal development|negative regulation of transcription, DNA-dependent		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity										CCGGCGCGCTCGGCGCTGCTC	0.657000													6	7					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34003079	34003079	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:34003079G>A	ENST00000373381.4	-	61	9938	c.9762C>T	c.(9760-9762)tgC>tgT	p.C3254C		NM_001281956.1|NM_052896.3	NP_001268885.1|NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3232						integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CATCTGACTGGCAAAACCTGC	0.612000													4	139					0	0	1	0	0
LETM1	3954	broad.mit.edu	37	4	1843116	1843116	+	Silent	SNP	G	G	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:1843116G>C	ENST00000302787.2	-	3	848	c.552C>G	c.(550-552)cgC>cgG	p.R184R		NM_012318.2	NP_036450.1	O95202	LETM1_HUMAN	leucine zipper-EF-hand containing transmembrane protein 1	184	LETM1.				cristae formation	integral to membrane|mitochondrial inner membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(2)|large_intestine(3)|lung(3)|prostate(1)|urinary_tract(1)	13			all cancers(2;0.00756)|OV - Ovarian serous cystadenocarcinoma(23;0.00989)|Epithelial(3;0.0141)			CGTTGAGGATGCGCCAGAGCA	0.602000													21	55					0	0	1	0	0
DDX20	11218	broad.mit.edu	37	1	112308560	112308560	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:112308560C>T	ENST00000475700.1	+	3	2696	c.338C>T	c.(337-339)tCa>tTa	p.S113L	DDX20_ENST00000369702.4_Missense_Mutation_p.S505L			Q9UHI6	DDX20_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	505	Helicase ATP-binding.				assembly of spliceosomal tri-snRNP|ncRNA metabolic process	Cajal body|cytoskeleton|cytosol|spliceosomal complex	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding			endometrium(3)|kidney(7)|large_intestine(6)|lung(3)|pancreas(1)|prostate(1)	21		all_cancers(81;1.06e-05)|all_epithelial(167;7.36e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.15e-05)		Lung(183;0.0234)|Colorectal(144;0.0282)|all cancers(265;0.0614)|Epithelial(280;0.0999)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCTGGACTATCAGTCAAATCA	0.363000													31	65					0	0	1	0	0
NUP93	9688	broad.mit.edu	37	16	56782202	56782202	+	Nonsense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr16:56782202C>T	ENST00000569842.1	+	2	139	c.43C>T	c.(43-45)Cag>Tag	p.Q15*	NUP93_ENST00000308159.5_Nonsense_Mutation_p.Q15*			Q8N1F7	NUP93_HUMAN	nucleoporin 93kDa	15					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding	p.Q15*(1)		breast(2)|endometrium(6)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27						GCAAGCTGAACAGCTTGCTGC	0.517000													67	52					0	0	1	0	0
HPGDS	27306	broad.mit.edu	37	4	95223384	95223384	+	Missense_Mutation	SNP	G	G	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:95223384G>T	ENST00000295256.5	-	5	438	c.348C>A	c.(346-348)ttC>ttA	p.F116L		NM_014485.2	NP_055300.1	O60760	HPGDS_HUMAN	hematopoietic prostaglandin D synthase	116	GST C-terminal.				locomotory behavior|prostaglandin biosynthetic process|signal transduction	cytoplasm|nucleus	calcium ion binding|glutathione transferase activity|magnesium ion binding|prostaglandin-D synthase activity|protein homodimerization activity	p.F116F(1)		breast(1)|cervix(1)|lung(3)|ovary(1)|urinary_tract(1)	7					Glutathione(DB00143)	GCAGCTCATTGAACATCTGCT	0.383000													7	190					0.248553	0.24882	1	1	0
TBC1D1	23216	broad.mit.edu	37	4	38134765	38134765	+	Nonsense_Mutation	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:38134765C>T	ENST00000261439.4	+	19	3548	c.3193C>T	c.(3193-3195)Caa>Taa	p.Q1065*	TBC1D1_ENST00000407365.1_3'UTR|TBC1D1_ENST00000508802.1_Nonsense_Mutation_p.Q1056*	NM_001253914.1|NM_001253915.1|NM_015173.3	NP_001240843.1|NP_001240844.1|NP_055988.2	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	1065						nucleus	Rab GTPase activator activity			NS(1)|breast(3)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	36						CCACGTCCTTCAAGAAGAACT	0.388000													45	46					0	0	1	0	0
MS4A5	64232	broad.mit.edu	37	11	60197253	60197253	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:60197253C>G	ENST00000300190.2	+	1	192	c.106C>G	c.(106-108)Caa>Gaa	p.Q36E	MS4A5_ENST00000534071.1_3'UTR	NM_023945.2	NP_076434.2	Q9H3V2	MS4A5_HUMAN	membrane-spanning 4-domains, subfamily A, member 5	36						integral to membrane	receptor activity			large_intestine(7)|lung(7)|ovary(1)|skin(1)	16						CTTTTCAACTCAAAGCCCCTT	0.428000													22	124					0	0	1	0	0
MICAL2	9645	broad.mit.edu	37	11	12280083	12280083	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:12280083G>A	ENST00000256194.4	+	25	3499	c.3211G>A	c.(3211-3213)Gag>Aag	p.E1071K	MICAL2_ENST00000342902.5_Missense_Mutation_p.E1050K|MICAL2_ENST00000537344.1_Missense_Mutation_p.E881K|MICAL2_ENST00000527546.1_Missense_Mutation_p.E881K|MICAL2_ENST00000379612.3_Missense_Mutation_p.E845K	NM_001282663.1|NM_014632.2	NP_001269592.1|NP_055447.1	O94851	MICA2_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 2	1071						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	47				Epithelial(150;0.00552)		GAGACGGGCAGAGTTGAAGCA	0.438000													48	14					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127595513	127595513	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:127595513C>G	ENST00000508053.1	-	71	9347	c.8373G>C	c.(8371-8373)caG>caC	p.Q2791H	FBN2_ENST00000262464.4_Missense_Mutation_p.Q2791H			P35556	FBN2_HUMAN	fibrillin 2	2791					bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CTAGGCTGATCTGTTCAACCT	0.527000													69	102					0	0	1	0	0
USP4	7375	broad.mit.edu	37	3	49321496	49321496	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:49321496C>G	ENST00000351842.4	-	18	2331	c.2323G>C	c.(2323-2325)Gtg>Ctg	p.V775L	USP4_ENST00000265560.4_Missense_Mutation_p.V822L	NM_199443.2	NP_955475.1	Q13107	UBP4_HUMAN	ubiquitin specific peptidase 4 (proto-oncogene)	822					negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|liver(1)|lung(10)|ovary(3)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		AGGTGGACCACCAGGATCTTG	0.468000													30	95					0	0	1	0	0
ACTR8	93973	broad.mit.edu	37	3	53912421	53912421	+	Missense_Mutation	SNP	G	G	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:53912421G>T	ENST00000335754.3	-	3	468	c.368C>A	c.(367-369)tCc>tAc	p.S123Y	ACTR8_ENST00000482349.1_Missense_Mutation_p.S12Y	NM_022899.4	NP_075050.3	Q9H981	ARP8_HUMAN	ARP8 actin-related protein 8 homolog (yeast)	123					cell division|DNA recombination|DNA repair|mitosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex	protein binding			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)	19				BRCA - Breast invasive adenocarcinoma(193;0.000143)|KIRC - Kidney renal clear cell carcinoma(284;0.00544)|Kidney(284;0.00607)|OV - Ovarian serous cystadenocarcinoma(275;0.111)		TGTACCATTGGACATCTTTTT	0.368000													90	119					1.21964e-59	1.34074e-59	1	1	0
DOCK2	1794	broad.mit.edu	37	5	169454900	169454900	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:169454900G>A	ENST00000256935.8	+	34	3495	c.3415G>A	c.(3415-3417)Gag>Aag	p.E1139K	DOCK2_ENST00000520908.1_Missense_Mutation_p.E631K|DOCK2_ENST00000523351.1_3'UTR|DOCK2_ENST00000540750.1_Missense_Mutation_p.E200K	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1139	DHR-2.|Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GCTGGACCACGAGGTAGAAGG	0.478000													17	58					0	0	1	0	0
EPB41L1	2036	broad.mit.edu	37	20	34782186	34782186	+	Silent	SNP	C	C	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr20:34782186C>T	ENST00000338074.2	+	12	1514	c.1353C>T	c.(1351-1353)gaC>gaT	p.D451D	EPB41L1_ENST00000373950.2_Silent_p.D354D|EPB41L1_ENST00000373946.3_Silent_p.D420D|EPB41L1_ENST00000373941.1_Silent_p.D451D|EPB41L1_ENST00000441639.1_Silent_p.D389D|EPB41L1_ENST00000202028.5_Silent_p.D389D	NM_001258329.1|NM_012156.2	NP_001245258.1|NP_036288.2	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	451					cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(10)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	37	Breast(12;0.0239)					CAGGGCCTGACGGTGACAAGC	0.602000													9	69					0	0	1	0	0
FOXS1	2307	broad.mit.edu	37	20	30432977	30432977	+	Silent	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr20:30432977G>A	ENST00000375978.3	-	1	443	c.369C>T	c.(367-369)acC>acT	p.T123T		NM_004118.3	NP_004109.1	O43638	FOXS1_HUMAN	forkhead box S1	123					anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|insulin receptor signaling pathway|lymphangiogenesis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|neural crest cell fate commitment|neuromuscular process controlling balance|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of multicellular organism growth|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|somitogenesis|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			kidney(1)|large_intestine(3)|lung(3)|ovary(1)|urinary_tract(1)	9						CGGGGCCCCGGGTGCCCTCAG	0.701000													48	15					0	0	1	0	0
CXorf66	347487	broad.mit.edu	37	X	139040374	139040374	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chrX:139040374C>G	ENST00000370540.1	-	2	114	c.91G>C	c.(91-93)Gat>Cat	p.D31H		NM_001013403.2	NP_001013421.1	Q5JRM2	CX066_HUMAN	chromosome X open reading frame 66	31						integral to membrane				breast(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(13)|skin(1)|stomach(1)	26						ACAGGTTTATCTCCTGCAAAG	0.308000													10	71					0	0	1	0	0
ITGAL	3683	broad.mit.edu	37	16	30515559	30515559	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr16:30515559G>A	ENST00000356798.6	+	18	2389	c.2209G>A	c.(2209-2211)Gaa>Aaa	p.E737K	ITGAL_ENST00000433423.2_Intron|ITGAL_ENST00000358164.5_Missense_Mutation_p.E654K	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	737					blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	TTGGGAGGAGGAAGGGACACC	0.498000													63	52					0	0	1	0	0
ACAD9	28976	broad.mit.edu	37	3	128612446	128612446	+	Missense_Mutation	SNP	T	T	C			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:128612446T>C	ENST00000308982.7	+	3	374	c.293T>C	c.(292-294)tTg>tCg	p.L98S		NM_014049.4	NP_054768.2	Q9H845	ACAD9_HUMAN	acyl-CoA dehydrogenase family, member 9	98						mitochondrion	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding			central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(12)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	30						GATGAAACTTTGGAGAAATTG	0.408000													12	35					0	0	1	0	0
MARK2	2011	broad.mit.edu	37	11	63676593	63676593	+	Nonsense_Mutation	SNP	G	G	T			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr11:63676593G>T	ENST00000402010.2	+	19	2830	c.2251G>T	c.(2251-2253)Gag>Tag	p.E751*	MARK2_ENST00000425897.2_Nonsense_Mutation_p.E662*|MARK2_ENST00000408948.3_Nonsense_Mutation_p.E654*|MARK2_ENST00000377810.3_Nonsense_Mutation_p.E654*|MARK2_ENST00000350490.7_Nonsense_Mutation_p.E672*|MARK2_ENST00000513765.2_Nonsense_Mutation_p.E718*|MARK2_ENST00000502399.3_Nonsense_Mutation_p.E741*|MARK2_ENST00000377809.4_Nonsense_Mutation_p.E736*|MARK2_ENST00000361128.5_Nonsense_Mutation_p.E682*|MARK2_ENST00000509502.2_Nonsense_Mutation_p.E708*|MARK2_ENST00000315032.8_Nonsense_Mutation_p.E742*|MARK2_ENST00000508192.1_Nonsense_Mutation_p.E687*|MARK2_ENST00000413835.2_Nonsense_Mutation_p.E697*	NM_001039469.2	NP_001034558.2	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	751	KA1.				cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33						GTGGGAGATGGAGGTGTGCAA	0.577000													67	64					7.59065e-32	8.26616e-32	1	1	0
TMCO2	127391	broad.mit.edu	37	1	40713708	40713709	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr1:40713708_40713709delTC	ENST00000372766.3	+	1	136_137	c.43_44delTC	c.(43-45)tctfs	p.S15fs	TMCO2_ENST00000468258.1_Intron	NM_001008740.3	NP_001008740.1	Q7Z6W1	TMCO2_HUMAN	transmembrane and coiled-coil domains 2	15						integral to membrane				kidney(1)|large_intestine(3)|lung(1)|ovary(1)	6	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;6.3e-18)			CCTCTTAGAGTCTCTCTCTCTC	0.406													7	507	---	---	---	---					
PPARG	5468	broad.mit.edu	37	3	12393148	12393149	+	Frame_Shift_Ins	INS	-	-	A			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr3:12393148_12393149insA	ENST00000287820.6	+	1	178_179	c.57_58insA	c.(58-60)acafs	p.T20fs	PPARG_ENST00000397015.2_Intron|PPARG_ENST00000539812.1_Intron|PPARG_ENST00000397000.1_Intron|PPARG_ENST00000397026.2_Intron|PPARG_ENST00000309576.6_Intron|PPARG_ENST00000397012.2_Intron|PPARG_ENST00000397010.2_Intron	NM_015869.4	NP_056953.2	P37231	PPARG_HUMAN	peroxisome proliferator-activated receptor gamma	20					activation of caspase activity|cell fate commitment|cell maturation|cellular response to insulin stimulus|epithelial cell differentiation|glucose homeostasis|induction of apoptosis|innate immune response|lipid homeostasis|lipoprotein transport|long-chain fatty acid transport|low-density lipoprotein particle receptor biosynthetic process|monocyte differentiation|negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of macrophage derived foam cell differentiation|negative regulation of receptor biosynthetic process|negative regulation of sequestering of triglyceride|negative regulation of transcription from RNA polymerase II promoter|placenta development|positive regulation of fat cell differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to lipid|response to low-density lipoprotein particle stimulus|white fat cell differentiation	cytosol|nucleoplasm	activating transcription factor binding|arachidonic acid binding|drug binding|enzyme binding|prostaglandin receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding		PAX8/PPARG(117)	breast(2)|endometrium(4)|kidney(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(1)|stomach(1)	20					Atorvastatin(DB01076)|Icosapent(DB00159)|Pioglitazone(DB01132)|Rosiglitazone(DB00412)|Troglitazone(DB00197)	CCTTCACTGATACACTGTCTGC	0.421			T	PAX8	follicular thyroid		"""Insulin resistance ; lipodystrophy, familial partial L;diabetes mellitus, insulin-resistantI, with acanthosis nigricans and hypertension"""						45	60	---	---	---	---					
GPM6A	2823	broad.mit.edu	37	4	176622891	176622891	+	Frame_Shift_Del	DEL	A	A	-			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr4:176622891delA	ENST00000280187.7	-	3	110	c.65delT	c.(64-66)ctgfs	p.L22fs	GPM6A_ENST00000515090.1_Frame_Shift_Del_p.L15fs|GPM6A_ENST00000393658.2_Frame_Shift_Del_p.L22fs|GPM6A_ENST00000506894.1_Frame_Shift_Del_p.L11fs	NM_005277.4	NP_005268.1	P51674	GPM6A_HUMAN	glycoprotein M6A	22						cell surface|integral to membrane				NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(16)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	33		Breast(14;7.35e-05)|Melanoma(52;0.00909)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;9.21e-19)|Epithelial(43;3.01e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.02e-09)|STAD - Stomach adenocarcinoma(60;0.00083)|GBM - Glioblastoma multiforme(59;0.00168)|LUSC - Lung squamous cell carcinoma(193;0.0388)		AATGCCCCCCAGGCATTTGAT	0.438													8	169	---	---	---	---					
DCTN4	51164	broad.mit.edu	37	5	150112943	150112943	+	Frame_Shift_Del	DEL	G	G	-			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:150112943delG	ENST00000447998.2	-	5	639	c.524delC	c.(523-525)cctfs	p.P175fs	DCTN4_ENST00000424236.1_Frame_Shift_Del_p.P118fs|DCTN4_ENST00000446090.2_Frame_Shift_Del_p.P175fs	NM_016221.3	NP_057305.1	Q9UJW0	DCTN4_HUMAN	dynactin 4 (p62)	175						centrosome|nucleus	protein N-terminus binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	10		Medulloblastoma(196;0.167)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AAAAGCCAGAGGCATATAGTT	0.403													34	36	---	---	---	---					
AACSP1	729522	broad.mit.edu	37	5	178208258	178208259	+	RNA	DEL	CA	CA	-			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr5:178208258_178208259delCA	ENST00000503486.2	-	0	647					NR_024035.1																						ACACCACAGCCACACACTGGCT	0.495													41	22	---	---	---	---					
HDAC9	9734	broad.mit.edu	37	7	19015468	19015468	+	Frame_Shift_Del	DEL	G	G	-			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr7:19015468delG	ENST00000406451.4	+	25	3203	c.3053delG	c.(3052-3054)aggfs	p.R1018fs	HDAC9_ENST00000441542.2_Frame_Shift_Del_p.R1021fs|HDAC9_ENST00000401921.1_Frame_Shift_Del_p.R977fs	NM_178423.1	NP_848510.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9						B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	GCTGTGCCAAGGGGCTGTGCT	0.473													13	46	---	---	---	---					
SLCO1A2	6579	broad.mit.edu	37	12	21471747	21471747	+	Frame_Shift_Del	DEL	T	T	-			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:21471747delT	ENST00000307378.6	-	4	891	c.171delA	c.(169-171)ctafs	p.L57fs	SLCO1A2_ENST00000537524.1_5'UTR|SLCO1A2_ENST00000473830.1_5'UTR|SLCO1A2_ENST00000390670.3_Frame_Shift_Del_p.L55fs|SLCO1A2_ENST00000452078.1_Frame_Shift_Del_p.L57fs|SLCO1A2_ENST00000458504.1_Intron	NM_134431.3	NP_602307.1	P46721	SO1A2_HUMAN	solute carrier organic anion transporter family, member 1A2	57					bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(2)|endometrium(2)|kidney(4)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(6)|upper_aerodigestive_tract(1)	48						TGAATCCAACTAGAGATGTTG	0.328													17	21	---	---	---	---					
ATP2A2	488	broad.mit.edu	37	12	110777366	110777366	+	Frame_Shift_Del	DEL	T	T	-			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:110777366delT	ENST00000395494.2	+	12	2083	c.1520delT	c.(1519-1521)gttfs	p.V507fs	ATP2A2_ENST00000539276.2_Frame_Shift_Del_p.V534fs|ATP2A2_ENST00000308664.6_Frame_Shift_Del_p.V534fs			P16615	AT2A2_HUMAN	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	534					ATP biosynthetic process|cell adhesion|epidermis development|platelet activation|sarcoplasmic reticulum calcium ion transport	integral to plasma membrane|microsome|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|protein C-terminus binding|S100 alpha binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(10)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(1)	38						AGTACTAAGGTTCCTATGACC	0.473													24	18	---	---	---	---					
RILPL1	353116	broad.mit.edu	37	12	123984042	123984042	+	Frame_Shift_Del	DEL	C	C	-			TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr12:123984042delC	ENST00000376874.4	-	3	737	c.502delG	c.(502-504)gagfs	p.E168fs	RILPL1_ENST00000340724.6_Frame_Shift_Del_p.E16fs	NM_178314.3	NP_847884.2	Q5EBL4	RIPL1_HUMAN	Rab interacting lysosomal protein-like 1	168					neuroprotection	cytosol				endometrium(1)|kidney(2)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	7	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000224)|Epithelial(86;0.00067)|all cancers(50;0.00836)|BRCA - Breast invasive adenocarcinoma(302;0.197)		TCCACCACCTCCTTCAGCTTC	0.582													9	51	---	---	---	---					
POLI	11201	broad.mit.edu	37	18	51795958	51795960	+	In_Frame_Del	DEL	CGA	CGA	-	rs140689079		TCGA-E5-A4U1-01A-11D-A31L-08	TCGA-E5-A4U1-10B-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9e8603c2-04a1-49ba-ad77-4e1b7fe466ff	8e765c17-4490-44d3-95e0-b4f4b99f9513	g.chr18:51795958_51795960delCGA	ENST00000579534.1	+	1	185_187	c.42_44delCGA	c.(40-45)ggcgac>ggc	p.D17del	POLI_ENST00000406285.3_In_Frame_Del_p.D17del|POLI_ENST00000579434.1_5'UTR	NM_007195.2	NP_009126.2	Q9UNA4	POLI_HUMAN	polymerase (DNA directed) iota	17					DNA repair|DNA replication	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding|protein binding	p.D17delD(1)		breast(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(5)|ovary(3)|urinary_tract(1)	26				Colorectal(16;0.0234)|READ - Rectum adenocarcinoma(59;0.197)		AAGGCGGCGGCGACGACGACGAG	0.729								DNA polymerases (catalytic subunits)					5	2	---	---	---	---