Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
LIPE	3991	broad.mit.edu	37	19	42931254	42931254	+	Silent	SNP	T	T	C			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:42931254T>C	ENST00000244289.4	-	1	324	c.48A>G	c.(46-48)gaA>gaG	p.E16E	LIPE-AS1_ENST00000457234.2_RNA|LIPE-AS1_ENST00000594624.2_RNA|LIPE-AS1_ENST00000597203.1_RNA|LIPE-AS1_ENST00000593740.2_RNA|LIPE-AS1_ENST00000594688.1_RNA	NM_005357.2	NP_005348.2	Q05469	LIPS_HUMAN	lipase, hormone-sensitive	16					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			breast(2)|endometrium(4)|kidney(7)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	32		Prostate(69;0.00682)				TCTGGTGTGGTTCAGGTTGCC	0.517000													7	28					0	0	0.006214	0	0
CSK	1445	broad.mit.edu	37	15	75094356	75094356	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr15:75094356G>A	ENST00000220003.9	+	12	1831	c.1102G>A	c.(1102-1104)Gac>Aac	p.D368N	CSK_ENST00000567571.1_Missense_Mutation_p.D368N|CSK_ENST00000309470.9_Missense_Mutation_p.D368N|CSK_ENST00000439220.2_Missense_Mutation_p.D368N	NM_004383.2	NP_004374.1	P41240	CSK_HUMAN	c-src tyrosine kinase	368	Protein kinase.				blood coagulation|epidermal growth factor receptor signaling pathway|T cell costimulation|T cell receptor signaling pathway	centrosome|cytosol|Golgi apparatus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein C-terminus binding			central_nervous_system(1)|lung(2)	3						CACTAAGTCTGACGTGTGGAG	0.532000													26	52					0	0	0.015359	0	0
IRS4	8471	broad.mit.edu	37	X	107978119	107978119	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chrX:107978119C>T	ENST00000372129.2	-	1	1532	c.1456G>A	c.(1456-1458)Gac>Aac	p.D486N		NM_003604.2	NP_003595.1	O14654	IRS4_HUMAN	insulin receptor substrate 4	486						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(1)	78						GGCATGTAGTCACCTCCGCTT	0.577000													7	78					0	0	0.004482	0	0
TAF6	6878	broad.mit.edu	37	7	99709745	99709745	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr7:99709745C>T	ENST00000344095.4	-	7	1231	c.706G>A	c.(706-708)Gag>Aag	p.E236K	TAF6_ENST00000437822.2_Missense_Mutation_p.E273K|TAF6_ENST00000418432.2_Missense_Mutation_p.E160K|TAF6_ENST00000472509.1_Missense_Mutation_p.E293K|TAF6_ENST00000453269.2_Missense_Mutation_p.E236K|TAF6_ENST00000452041.1_Missense_Mutation_p.E236K	NM_005641.3	NP_005632.1	P49848	TAF6_HUMAN	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa	236					negative regulation of cell cycle|negative regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|urinary_tract(2)	26	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CTCTTGGCCTCGCAGGAGCCC	0.672000													7	12					0	0	0.003080	0	0
ZNF599	148103	broad.mit.edu	37	19	35251038	35251038	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:35251038C>G	ENST00000329285.8	-	4	1041	c.668G>C	c.(667-669)gGa>gCa	p.G223A		NM_001007248.2	NP_001007249.1	Q96NL3	ZN599_HUMAN	zinc finger protein 599						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(10)|lung(8)|ovary(1)|pancreas(1)|skin(1)	24	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)			GGGCTTCACTCCAGCATGAAT	0.473000													6	204					0	0	0.004482	0	0
SDSL	113675	broad.mit.edu	37	12	113873341	113873341	+	Silent	SNP	C	C	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr12:113873341C>G	ENST00000403593.4	+	6	913	c.651C>G	c.(649-651)gtC>gtG	p.V217V	SDSL_ENST00000345635.4_Silent_p.V217V			Q96GA7	SDSL_HUMAN	serine dehydratase-like	217					cellular amino acid metabolic process		L-serine ammonia-lyase activity|L-threonine ammonia-lyase activity|pyridoxal phosphate binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)	15					Pyridoxal Phosphate(DB00114)	GCAAGCTGGTCACACTTCCAG	0.622000													35	180					0	0	0.036044	0	0
ZNF564	163050	broad.mit.edu	37	19	12637723	12637723	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:12637723C>T	ENST00000339282.7	-	4	1395	c.1199G>A	c.(1198-1200)aGa>aAa	p.R400K	CTD-2192J16.20_ENST00000593682.1_3'UTR|ZNF709_ENST00000428311.1_Intron	NM_144976.3	NP_659413.1			zinc finger protein 564											endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	18						GTCAAAGGCTCTACCACATAC	0.433000													5	118					0	0	0.021553	0	0
BCL2L13	23786	broad.mit.edu	37	22	18210132	18210132	+	Silent	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr22:18210132G>A	ENST00000317582.5	+	7	1637	c.1290G>A	c.(1288-1290)gaG>gaA	p.E430E	BCL2L13_ENST00000543133.1_Silent_p.E268E|BCL2L13_ENST00000538149.1_Silent_p.E306E|BCL2L13_ENST00000355028.3_3'UTR|BCL2L13_ENST00000485631.1_3'UTR|BCL2L13_ENST00000337612.5_Silent_p.E268E|BCL2L13_ENST00000418951.2_3'UTR	NM_015367.3	NP_056182.2	Q9BXK5	B2L13_HUMAN	BCL2-like 13 (apoptosis facilitator)	430					induction of apoptosis	integral to membrane|mitochondrial membrane|nucleus	caspase activator activity			breast(2)|central_nervous_system(1)|large_intestine(2)|liver(2)|lung(2)|ovary(1)|skin(3)|urinary_tract(2)	15		all_epithelial(15;0.123)		Lung(27;0.199)		CTGCCAGCGAGAAGAAGCCCG	0.592000													12	29					0	0	0.016723	0	0
ITGB4	3691	broad.mit.edu	37	17	73723498	73723498	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr17:73723498G>A	ENST00000200181.3	+	4	363	c.176G>A	c.(175-177)cGg>cAg	p.R59Q	ITGB4_ENST00000339591.3_Missense_Mutation_p.R59Q|ITGB4_ENST00000579662.1_Missense_Mutation_p.R59Q|ITGB4_ENST00000584558.1_3'UTR|ITGB4_ENST00000450894.3_Missense_Mutation_p.R59Q|ITGB4_ENST00000449880.2_Missense_Mutation_p.R59Q	NM_000213.3	NP_000204.3	P16144	ITB4_HUMAN	integrin, beta 4	59	PSI.				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(1)|lung(25)|skin(1)|urinary_tract(1)	43	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			TTCAGGGACCGGCGCTGCAAC	0.637000													10	41					0	0	0.016723	0	0
NFASC	23114	broad.mit.edu	37	1	204951129	204951129	+	Silent	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr1:204951129C>T	ENST00000367172.4	+	21	2779	c.2451C>T	c.(2449-2451)atC>atT	p.I817I	NFASC_ENST00000539706.1_Silent_p.I813I|NFASC_ENST00000367169.4_Silent_p.I817I|NFASC_ENST00000360049.4_Silent_p.I813I|NFASC_ENST00000401399.1_Silent_p.I817I|NFASC_ENST00000338586.6_Silent_p.I817I|NFASC_ENST00000367171.4_Silent_p.I802I|NFASC_ENST00000338515.6_Silent_p.I817I|NFASC_ENST00000404907.1_Silent_p.I813I|NFASC_ENST00000513543.1_Silent_p.I813I|NFASC_ENST00000367170.4_Silent_p.I817I|NFASC_ENST00000339876.6_Silent_p.I817I|NFASC_ENST00000404076.1_Silent_p.I796I			O94856	NFASC_HUMAN	neurofascin	817	Fibronectin type-III 2.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			AGTCCGTCATCGGTTACTCCG	0.607000													9	19					0	0	0.016723	0	0
CER1	9350	broad.mit.edu	37	9	14720234	14720234	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr9:14720234G>A	ENST00000380911.3	-	2	702	c.658C>T	c.(658-660)Cca>Tca	p.P220S		NM_005454.2	NP_005445.1	O95813	CER1_HUMAN	cerberus 1, DAN family BMP antagonist	220	CTCK.				BMP signaling pathway	extracellular space	cytokine activity			endometrium(2)|large_intestine(3)|lung(6)	11				GBM - Glioblastoma multiforme(50;3.16e-06)		CAGTTCAGTGGCAAGTGCATC	0.542000													5	134					0	0	0.003080	0	0
XPOT	11260	broad.mit.edu	37	12	64812808	64812808	+	Silent	SNP	C	C	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr12:64812808C>G	ENST00000332707.5	+	6	952	c.423C>G	c.(421-423)ctC>ctG	p.L141L		NM_007235.4	NP_009166.2	O43592	XPOT_HUMAN	exportin, tRNA	141	Necessary for interaction with Ran, nuclear localization and nuclear import.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding	p.L141L(1)		NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(7)|lung(12)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				GBM - Glioblastoma multiforme(28;0.0404)		GAGTAGATCTCTACCTGCGAA	0.398000													9	98					0	0	0.006214	0	0
IRS4	8471	broad.mit.edu	37	X	107977998	107977998	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chrX:107977998C>T	ENST00000372129.2	-	1	1653	c.1577G>A	c.(1576-1578)gGa>gAa	p.G526E		NM_003604.2	NP_003595.1	O14654	IRS4_HUMAN	insulin receptor substrate 4	526						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(1)	78						GGATCCCTGTCCCTCGCCTGA	0.632000													16	130					0	0	0.012319	0	0
FOXD2	2306	broad.mit.edu	37	1	47904409	47904409	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr1:47904409G>A	ENST00000334793.5	+	1	2721	c.602G>A	c.(601-603)tGg>tAg	p.W201*		NM_004474.3	NP_004465.3	O60548	FOXD2_HUMAN	forkhead box D2	201					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			lung(4)	4				READ - Rectum adenocarcinoma(2;0.0908)		GGCAACTACTGGACGCTGGAC	0.672000													53	131					0	0	0.014410	0	0
ZNF652	22834	broad.mit.edu	37	17	47395037	47395037	+	Silent	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr17:47395037C>T	ENST00000362063.2	-	2	369	c.51G>A	c.(49-51)gtG>gtA	p.V17V	ZNF652_ENST00000430262.2_Silent_p.V17V	NM_014897.2	NP_055712.1	Q9Y2D9	ZN652_HUMAN	zinc finger protein 652	17					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	20	all_cancers(4;6.81e-14)|Breast(4;4.97e-29)|all_epithelial(4;1.53e-17)		BRCA - Breast invasive adenocarcinoma(1;3.1e-14)|Epithelial(5;2.92e-06)|all cancers(6;3.15e-05)			CTGCTACATGCACAGCACAGT	0.448000													5	38					0	0	0.003080	0	0
ZNF248	57209	broad.mit.edu	37	10	38121105	38121105	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr10:38121105G>C	ENST00000395867.3	-	6	1728	c.1178C>G	c.(1177-1179)tCa>tGa	p.S393*	ZNF248_ENST00000374648.3_Intron|ZNF248_ENST00000494133.1_Intron|ZNF248_ENST00000357328.4_Nonsense_Mutation_p.S393*	NM_001267605.1|NM_001267606.1|NM_001267607.1|NM_021045.2	NP_001254534.1|NP_001254535.1|NP_001254536.1|NP_066383.1	Q8NDW4	ZN248_HUMAN	zinc finger protein 248	393					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|large_intestine(5)|lung(9)|ovary(2)|urinary_tract(1)	20						AGTGAGGTTTGACTTCTCCCA	0.453000													23	70					0	0	0.016522	0	0
HOXC4	3221	broad.mit.edu	37	12	54448079	54448079	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr12:54448079C>T	ENST00000430889.2	+	1	419	c.373C>T	c.(373-375)Ccc>Tcc	p.P125S	HOXC4_ENST00000609810.1_Missense_Mutation_p.P125S|HOXC4_ENST00000303406.4_Missense_Mutation_p.P125S	NM_153633.2	NP_705897.1	P09017	HXC4_HUMAN	homeobox C4	125						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|urinary_tract(1)	13						CCCCGACCATCCCTCCAGCGC	0.637000													6	27					0	0	0.003080	0	0
AKAP7	9465	broad.mit.edu	37	6	131490373	131490373	+	Silent	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr6:131490373G>A	ENST00000431975.2	+	5	647	c.549G>A	c.(547-549)ctG>ctA	p.L183L	AKAP7_ENST00000368123.4_Silent_p.L161L|AKAP7_ENST00000366358.2_Intron|AKAP7_ENST00000541650.1_Silent_p.L182L	NM_016377.3	NP_057461.2	O43687	AKA7A_HUMAN	A kinase (PRKA) anchor protein 7	0					intracellular signal transduction|ion transport	apical plasma membrane|intracellular|lateral plasma membrane	protein kinase A binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)|stomach(1)	13	Breast(56;0.152)			GBM - Glioblastoma multiforme(226;0.0184)|OV - Ovarian serous cystadenocarcinoma(155;0.0345)		TTGTGAAGCTGGCAGAAGGAG	0.378000													34	102					0	0	0.030466	0	0
FANCD2	2177	broad.mit.edu	37	3	10107166	10107166	+	Missense_Mutation	SNP	G	G	A	rs150217066		TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr3:10107166G>A	ENST00000287647.3	+	24	2350	c.2257G>A	c.(2257-2259)Gat>Aat	p.D753N	FANCD2_ENST00000383806.1_Missense_Mutation_p.D753N|FANCD2_ENST00000419585.1_Missense_Mutation_p.D753N|FANCD2_ENST00000383807.1_Missense_Mutation_p.D753N	NM_033084.3	NP_149075.2	Q9BXW9	FACD2_HUMAN	Fanconi anemia, complementation group D2	753					DNA repair|response to gamma radiation	nucleoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	51				OV - Ovarian serous cystadenocarcinoma(96;0.148)		GGAGGAGATTGATGGTCTACT	0.448000			"""D, Mis, N, F"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				28	57					0	0	0.013726	0	0
GRAMD1C	54762	broad.mit.edu	37	3	113619898	113619898	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr3:113619898C>G	ENST00000358160.4	+	7	1053	c.561C>G	c.(559-561)ttC>ttG	p.F187L	GRAMD1C_ENST00000452134.2_5'UTR|GRAMD1C_ENST00000479212.1_3'UTR|GRAMD1C_ENST00000472026.1_Missense_Mutation_p.F20L|GRAMD1C_ENST00000440446.2_5'UTR	NM_017577.4	NP_060047.3	Q8IYS0	GRM1C_HUMAN	GRAM domain containing 1C	187						integral to membrane				NS(1)|endometrium(1)|large_intestine(6)|lung(13)|ovary(2)|skin(3)	26						GACAGGAATTCTGGCAACTGC	0.393000													20	48					0	0	0.018920	0	0
PKD1L1	168507	broad.mit.edu	37	7	47832313	47832313	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr7:47832313G>C	ENST00000289672.2	-	56	8488	c.8438C>G	c.(8437-8439)cCc>cGc	p.P2813R		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	2813					cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						TTCCAGAAGGGGGAGTTGTAG	0.428000													27	64					0	0	0.037714	0	0
PRDM7	11105	broad.mit.edu	37	16	90126823	90126823	+	Missense_Mutation	SNP	T	T	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr16:90126823T>G	ENST00000449207.2	-	9	1178	c.1159A>C	c.(1159-1161)Atg>Ctg	p.M387L	PRDM7_ENST00000407825.1_Intron|PRDM7_ENST00000325921.6_Intron	NM_001098173.1	NP_001091643.1	Q9NQW5	PRDM7_HUMAN	PR domain containing 7	387						chromosome|nucleus	nucleic acid binding			lung(2)|ovary(2)|stomach(1)	5		all_cancers(9;4.44e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.00118)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		CTCATCCCCATACCAGACCAG	0.522000													3	64					0	0	0.004672	0	0
CCRN4L	25819	broad.mit.edu	37	4	139966392	139966392	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr4:139966392G>C	ENST00000280614.2	+	3	1253	c.1060G>C	c.(1060-1062)Gat>Cat	p.D354H	ELF2_ENST00000515489.1_Intron	NM_012118.2	NP_036250.2	Q9UK39	NOCT_HUMAN	CCR4 carbon catabolite repression 4-like (S. cerevisiae)	354					rhythmic process|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity			kidney(2)|large_intestine(3)|lung(3)|ovary(1)	9	all_hematologic(180;0.162)					GCTGAGTGCTGATGGGCAGTC	0.517000													15	47					0	0	0.033300	0	0
ZNF577	84765	broad.mit.edu	37	19	52376698	52376698	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:52376698C>A	ENST00000420592.1	-	6	1701	c.368G>T	c.(367-369)gGa>gTa	p.G123V	ZNF577_ENST00000485702.1_Intron|ZNF577_ENST00000412216.1_Intron|ZNF577_ENST00000301399.5_Missense_Mutation_p.G182V|ZNF577_ENST00000451628.2_Missense_Mutation_p.G123V			Q9BSK1	ZN577_HUMAN	zinc finger protein 577	182			R -> C (in dbSNP:rs17849895).		regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	21		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		GGGTTTCTCTCCTCTTTCAGT	0.468000													4	88					0.000602214	0.000628398	0.014758	1	0
TP53	7157	broad.mit.edu	37	17	7577085	7577085	+	Missense_Mutation	SNP	C	C	T	rs112431538		TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr17:7577085C>T	ENST00000420246.2	-	8	985	c.853G>A	c.(853-855)Gag>Aag	p.E285K	TP53_ENST00000413465.2_Intron|TP53_ENST00000359597.4_Missense_Mutation_p.E285K|TP53_ENST00000455263.2_Missense_Mutation_p.E285K|TP53_ENST00000445888.2_Missense_Mutation_p.E285K|TP53_ENST00000269305.4_Missense_Mutation_p.E285K	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	285	Interaction with AXIN1 (By similarity).|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		E -> A (in a sporadic cancer; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).|E -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E285K(111)|p.E285*(24)|p.0?(8)|p.E285Q(4)|p.?(2)|p.R283fs*16(2)|p.C275fs*20(1)|p.R282_E287delRRTEEE(1)|p.L265_K305del41(1)|p.T284fs*57(1)|p.T284_G293del10(1)|p.E285_L289delEEENL(1)|p.E285fs*60(1)|p.G279fs*59(1)|p.R283fs*56(1)|p.E285fs*20(1)|p.E285fs*13(1)|p.R283fs*59(1)|p.V272_K292del21(1)|p.E285_N288delEEEN(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTCTCTTCCTCTGTGCGCCGG	0.562000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			18	23					0	0	0.007413	0	0
CASD1	64921	broad.mit.edu	37	7	94164632	94164632	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr7:94164632G>A	ENST00000297273.4	+	8	927	c.640G>A	c.(640-642)Gaa>Aaa	p.E214K		NM_022900.4	NP_075051.4	Q96PB1	CASD1_HUMAN	CAS1 domain containing 1	214						integral to membrane				NS(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(13)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	31	all_cancers(62;6.71e-10)|all_epithelial(64;5e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			TCCTGTTTATGAAGATCTATT	0.328000													14	42					0	0	0.028581	0	0
XPOT	11260	broad.mit.edu	37	12	64812733	64812733	+	Silent	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr12:64812733G>A	ENST00000332707.5	+	6	877	c.348G>A	c.(346-348)gaG>gaA	p.E116E		NM_007235.4	NP_009166.2	O43592	XPOT_HUMAN	exportin, tRNA	116	Necessary for interaction with Ran, nuclear localization and nuclear import.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding	p.E116E(1)		NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(7)|lung(12)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				GBM - Glioblastoma multiforme(28;0.0404)		TTGTTACAGAGTATCTCACTA	0.438000													5	42					0	0	0.021553	0	0
IRS4	8471	broad.mit.edu	37	X	107978233	107978233	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chrX:107978233C>T	ENST00000372129.2	-	1	1418	c.1342G>A	c.(1342-1344)Gaa>Aaa	p.E448K		NM_003604.2	NP_003595.1	O14654	IRS4_HUMAN	insulin receptor substrate 4	448						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(1)	78						TTCGGGGCTTCTGCAGGGTGC	0.612000													6	59					0	0	0.021553	0	0
ZNF229	7772	broad.mit.edu	37	19	44933766	44933766	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:44933766C>T	ENST00000291187.4	-	6	1494	c.1172G>A	c.(1171-1173)aGg>aAg	p.R391K	CTC-512J12.4_ENST00000588655.1_RNA|ZNF229_ENST00000588931.1_Missense_Mutation_p.R397K|ZNF229_ENST00000591289.1_Intron	NM_001278510.1	NP_001265439.1	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	397					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(2)|endometrium(6)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	45		Prostate(69;0.0352)				AGTGTGGACCCTCTGATGGAC	0.502000													32	51					0	0	0.013726	0	0
PANK1	53354	broad.mit.edu	37	10	91353589	91353589	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr10:91353589C>T	ENST00000307534.4	-	4	1623	c.1468G>A	c.(1468-1470)Gga>Aga	p.G490R	PANK1_ENST00000322191.6_Intron|PANK1_ENST00000371774.2_Missense_Mutation_p.G292R|PANK1_ENST00000342512.3_Missense_Mutation_p.G265R	NM_148977.2	NP_683878.1	Q8TE04	PANK1_HUMAN	pantothenate kinase 1	490					coenzyme A biosynthetic process|pantothenate metabolic process	cytosol|nucleus	ATP binding|pantothenate kinase activity			cervix(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(2)	11					Bezafibrate(DB01393)	ACAGCAGATCCTTGAAGGCCA	0.448000													7	155					0	0	0.008291	0	0
GABRR2	2570	broad.mit.edu	37	6	90024839	90024839	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr6:90024839C>A	ENST00000402938.3	-	1	179	c.46G>T	c.(46-48)Gtt>Ttt	p.V16F	GABRR2_ENST00000602808.1_5'UTR|GABRR2_ENST00000602399.1_Missense_Mutation_p.V41F	NM_002043.3	NP_002034.3	P28476	GBRR2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, rho 2	41					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(10)|prostate(2)|urinary_tract(1)	21		all_cancers(76;1.67e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.77e-07)|all_epithelial(107;2.51e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0158)		TCCACGAGAACCATCAAGCAA	0.473000													54	143					9.53978e-28	1.08168e-27	0.014410	1	0
OR14K1	343170	broad.mit.edu	37	1	247901963	247901963	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr1:247901963C>T	ENST00000283225.2	+	1	47	c.47C>T	c.(46-48)aCt>aTt	p.T16I	RP11-634B7.4_ENST00000449298.1_RNA					olfactory receptor, family 14, subfamily K, member 1											NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|lung(18)|ovary(1)|urinary_tract(1)	27						GTGAGATTTACTGAGAATTGG	0.408000													26	50					0	0	0.019004	0	0
SMARCAL1	50485	broad.mit.edu	37	2	217342939	217342939	+	Missense_Mutation	SNP	G	G	C	rs119473033		TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr2:217342939G>C	ENST00000357276.4	+	17	2872	c.2542G>C	c.(2542-2544)Gag>Cag	p.E848Q	SMARCAL1_ENST00000358207.5_Missense_Mutation_p.E848Q	NM_014140.3	NP_054859.2	Q9NZC9	SMAL1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1	848	Helicase C-terminal.				chromatin modification|DNA metabolic process|regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(10)|liver(1)|lung(15)|ovary(3)|prostate(1)|skin(1)	42		Renal(323;0.0458)		Epithelial(149;9.48e-06)|all cancers(144;0.000621)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0111)		CCTGATTCAAGAGAAGATTAA	0.458000									Schimke Immuno-Osseous Dysplasia				33	51					0	0	0.030466	0	0
MDGA2	161357	broad.mit.edu	37	14	47530528	47530528	+	Silent	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr14:47530528C>T	ENST00000426342.1	-	7	1301	c.555G>A	c.(553-555)acG>acA	p.T185T	MDGA2_ENST00000357362.3_Silent_p.T185T|MDGA2_ENST00000439988.3_Silent_p.T483T|MDGA2_ENST00000399232.2_Silent_p.T414T	NM_182830.3	NP_878250.2	Q7Z553	MDGA2_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 2	414	Ig-like 2.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				breast(3)|endometrium(4)|kidney(2)|large_intestine(14)|lung(41)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(5)	76						CACATGTGTACGTCCCAAAAT	0.408000													36	120					0	0	0.014410	0	0
PYGO2	90780	broad.mit.edu	37	1	154933468	154933468	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr1:154933468C>A	ENST00000368457.2	-	2	309	c.138G>T	c.(136-138)agG>agT	p.R46S	PYGO2_ENST00000483463.1_5'UTR|PYGO2_ENST00000368456.1_Missense_Mutation_p.R9S	NM_138300.3	NP_612157.1	Q9BRQ0	PYGO2_HUMAN	pygopus family PHD finger 2	46	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding|zinc ion binding	p.R46S(1)		endometrium(2)|large_intestine(2)|lung(3)|skin(2)|urinary_tract(1)	10	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			TATTTGACTTCCTTCGCTTCT	0.502000													8	436					6.40141e-05	6.82817e-05	0.010729	1	0
ZNF628	89887	broad.mit.edu	37	19	55993619	55993619	+	Silent	SNP	G	G	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:55993619G>T	ENST00000598519.1	+	3	1612	c.1059G>T	c.(1057-1059)gcG>gcT	p.A353A	ZNF628_ENST00000391718.2_Silent_p.A349A			Q5EBL2	ZN628_HUMAN	zinc finger protein 628	349						nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|lung(2)	7	Breast(117;0.155)		BRCA - Breast invasive adenocarcinoma(297;0.18)|LUSC - Lung squamous cell carcinoma(43;0.193)	GBM - Glioblastoma multiforme(193;0.0531)		CCGCCCCCGCGCCTGGCTTTG	0.771000													10	6					2.61681e-11	2.85471e-11	0.020292	1	0
SCGN	10590	broad.mit.edu	37	6	25665182	25665182	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr6:25665182G>A	ENST00000377961.2	+	4	426	c.258G>A	c.(256-258)atG>atA	p.M86I	SCGN_ENST00000334979.6_3'UTR	NM_006998.3	NP_008929.2	O76038	SEGN_HUMAN	secretagogin, EF-hand calcium binding protein	86	EF-hand 2.					extracellular region|transport vesicle membrane	calcium ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	24						TTGCTGGTATGTTCTTATCTG	0.478000													15	38					0	0	0.010504	0	0
ANKRD32	84250	broad.mit.edu	37	5	94027275	94027275	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr5:94027275C>A	ENST00000265140.5	+	19	2845	c.2426C>A	c.(2425-2427)aCa>aAa	p.T809K		NM_032290.3	NP_115666.2	Q9BQI6	ANR32_HUMAN	ankyrin repeat domain 32	809										NS(1)|breast(2)|endometrium(2)|large_intestine(1)|lung(3)|ovary(2)|prostate(1)|skin(1)	13		all_cancers(142;1.51e-09)|all_epithelial(76;4.68e-12)|all_lung(232;5.94e-05)|Ovarian(174;0.000953)|Lung NSC(167;0.00105)|Colorectal(57;0.122)|Lung SC(612;0.152)		all cancers(79;3.88e-18)		GCAGGAGAAACAGCCCTGCAT	0.353000													7	22					0.00621372	0.00643723	0.006214	1	0
NEB	4703	broad.mit.edu	37	2	152484126	152484126	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr2:152484126C>T	ENST00000427231.2	-	69	10256	c.10054G>A	c.(10054-10056)Gac>Aac	p.D3352N	NEB_ENST00000409198.1_Missense_Mutation_p.D3109N|NEB_ENST00000604864.1_Missense_Mutation_p.D3352N|NEB_ENST00000397345.3_Missense_Mutation_p.D3352N|NEB_ENST00000603639.1_Missense_Mutation_p.D3352N|NEB_ENST00000172853.10_Missense_Mutation_p.D3109N	NM_001164507.1|NM_001271208.1	NP_001157979|NP_001258137.1	P20929	NEBU_HUMAN	nebulin	3352					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TTCTTGTAGTCCACATCGCTG	0.522000													8	250					0	0	0.004482	0	0
STAB1	23166	broad.mit.edu	37	3	52552854	52552854	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr3:52552854C>G	ENST00000321725.6	+	48	5079	c.5003C>G	c.(5002-5004)tCa>tGa	p.S1668*		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	1668	FAS1 5.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		ACGGCCCTCTCAGGGCACCCA	0.721000													4	27					0	0	0.009096	0	0
LINC00471	151477	broad.mit.edu	37	2	232373905	232373905	+	RNA	SNP	C	C	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr2:232373905C>A	ENST00000313064.2	-	0	513					NR_024079.1																						TGTCTTCATTCTCCTGGTGGC	0.507000													62	115					1.58458e-29	1.81095e-29	0.014410	1	0
SIPA1L3	23094	broad.mit.edu	37	19	38579389	38579389	+	Silent	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:38579389G>A	ENST00000222345.6	+	4	2072	c.1563G>A	c.(1561-1563)gaG>gaA	p.E521E		NM_015073.1	NP_055888.1	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like 3	521					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(22)|ovary(2)|prostate(4)|skin(3)	59			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			GCGTGGATGAGAAGCTGGGGC	0.587000													15	33					0	0	0.020292	0	0
PLEC	5339	broad.mit.edu	37	8	145018067	145018067	+	Translation_Start_Site	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr8:145018067C>T	ENST00000354589.3	-	0	59				PLEC_ENST00000436759.2_Intron|PLEC_ENST00000398774.2_Intron|PLEC_ENST00000527096.1_Intron|PLEC_ENST00000354958.2_Intron|PLEC_ENST00000322810.4_Intron|PLEC_ENST00000356346.3_Intron	NM_201382.2	NP_958784.1	Q15149	PLEC_HUMAN	plectin						cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						ATAGCCGCCACGCGGAGCCGC	0.721000													5	14					0	0	0.029380	0	0
PDILT	204474	broad.mit.edu	37	16	20370721	20370721	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr16:20370721C>T	ENST00000302451.4	-	12	1923	c.1675G>A	c.(1675-1677)Gag>Aag	p.E559K		NM_174924.1	NP_777584.1	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis expressed	559					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|liver(1)|lung(33)|prostate(3)|skin(1)|urinary_tract(1)	61						ACCACCTCCTCAGATGTTTTC	0.493000													50	282					0	0	0.014410	0	0
TTN	7273	broad.mit.edu	37	2	179613777	179613777	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr2:179613777G>C	ENST00000360870.5	-	46	13572	c.13350C>G	c.(13348-13350)caC>caG	p.H4450Q	TTN_ENST00000589042.1_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	578	Ig-like 24.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCCCGGGTAGTGTATCTCTT	0.333000													4	35					0	0	0.014758	0	0
GNAZ	2781	broad.mit.edu	37	22	23438065	23438065	+	Silent	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr22:23438065C>T	ENST00000248996.4	+	2	849	c.183C>T	c.(181-183)ttC>ttT	p.F61F	RTDR1_ENST00000216036.4_Intron	NM_002073.2	NP_002064.1	P19086	GNAZ_HUMAN	guanine nucleotide binding protein (G protein), alpha z polypeptide	61						endoplasmic reticulum|heterotrimeric G-protein complex|nuclear envelope	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|metabotropic serotonin receptor binding|receptor signaling protein activity			endometrium(3)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|skin(5)|urinary_tract(1)	19	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.166)		GCGGCGGCTTCAACCTGGAGG	0.597000													56	98					0	0	0.014410	0	0
FRG1B	284802	broad.mit.edu	37	20	29625891	29625891	+	Silent	SNP	C	C	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr20:29625891C>G	ENST00000278882.3	+	5	515	c.135C>G	c.(133-135)ggC>ggG	p.G45G	FRG1B_ENST00000358464.4_Silent_p.G45G|FRG1B_ENST00000439954.2_Silent_p.G50G																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TGAAATCTGGCTATGGAAAAT	0.343000													3	54					0	0	0.009096	0	0
ZNF878	729747	broad.mit.edu	37	19	12155757	12155757	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:12155757C>A	ENST00000602107.1	-	5	599	c.600G>T	c.(598-600)agG>agT	p.R200S	CTD-2006C1.10_ENST00000547473.1_Intron|CTD-2006C1.2_ENST00000476474.1_RNA|CTD-2006C1.2_ENST00000591838.1_RNA|ZNF878_ENST00000547628.1_Missense_Mutation_p.R153S|CTD-2006C1.2_ENST00000591898.1_RNA			C9JN71	ZN878_HUMAN	zinc finger protein 878	153					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|lung(4)|urinary_tract(1)	8						AACTGGGAAACCTGAATGCTT	0.423000													7	94					5.18039e-06	5.56699e-06	0.003080	1	0
SYTL2	54843	broad.mit.edu	37	11	85420380	85420380	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr11:85420380G>C	ENST00000359152.5	-	6	4531	c.4532C>G	c.(4531-4533)tCa>tGa	p.S1511*	SYTL2_ENST00000389960.4_Nonsense_Mutation_p.S641*|SYTL2_ENST00000533892.1_Nonsense_Mutation_p.S67*|SYTL2_ENST00000529581.1_Nonsense_Mutation_p.S107*|SYTL2_ENST00000525702.1_Nonsense_Mutation_p.S107*|SYTL2_ENST00000354566.3_Nonsense_Mutation_p.S1003*|SYTL2_ENST00000527523.1_Nonsense_Mutation_p.S633*|SYTL2_ENST00000524452.1_Nonsense_Mutation_p.S641*|SYTL2_ENST00000525423.1_Nonsense_Mutation_p.S987*|SYTL2_ENST00000528231.1_Nonsense_Mutation_p.S665*|SYTL2_ENST00000316356.4_Nonsense_Mutation_p.S666*|SYTL2_ENST00000389958.3_Nonsense_Mutation_p.S96*	NM_206928.2	NP_996811.1	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2	665					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(22)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		TTACGGGTCTGAACGCTGTTT	0.413000													40	49					0	0	0.014410	0	0
LRRTM1	347730	broad.mit.edu	37	2	80530714	80530714	+	Silent	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr2:80530714G>A	ENST00000295057.3	-	2	887	c.231C>T	c.(229-231)ctC>ctT	p.L77L	CTNNA2_ENST00000541047.1_Intron|CTNNA2_ENST00000466387.1_Intron|CTNNA2_ENST00000402739.4_Intron|CTNNA2_ENST00000496558.1_Intron|CTNNA2_ENST00000361291.4_Intron|CTNNA2_ENST00000540488.1_Intron|LRRTM1_ENST00000409148.1_Silent_p.L77L	NM_178839.4	NP_849161.2	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	77						axon|endoplasmic reticulum membrane|growth cone|integral to membrane				NS(1)|breast(1)|endometrium(5)|large_intestine(7)|liver(1)|lung(33)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	63						GCAGCTCCGAGAGGCTGTTGT	0.647000										HNSCC(69;0.2)			4	63					0	0	0.009096	0	0
CROCCP3	114819	broad.mit.edu	37	1	16802945	16802945	+	RNA	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr1:16802945G>A	ENST00000263511.4	-	0	2386					NR_023386.1																						GGCTCTCGTTGAGGGCGCTCA	0.642000													24	71					0	0	0.021523	0	0
TFAP2B	7021	broad.mit.edu	37	6	50791308	50791308	+	Silent	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr6:50791308C>T	ENST00000263046.4	+	3	463	c.297C>T	c.(295-297)aaC>aaT	p.N99N	TFAP2B_ENST00000393655.3_Silent_p.N90N|TFAP2B_ENST00000489228.1_3'UTR			Q92481	AP2B_HUMAN	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)	90	Gln/Pro-rich (transactivation domain).				nervous system development|positive regulation of transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(11)|lung(16)|prostate(2)|upper_aerodigestive_tract(1)	40	Lung NSC(77;0.156)					CCCACGTCAACGACCCCTACT	0.672000													26	59					0	0	0.012213	0	0
TENM4	26011	broad.mit.edu	37	11	78419499	78419499	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr11:78419499G>C	ENST00000278550.7	-	27	4578	c.4116C>G	c.(4114-4116)atC>atG	p.I1372M		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		CATTCTGATCGATGCGTCTGA	0.507000													37	20					0	0	0.025465	0	0
PDZD2	23037	broad.mit.edu	37	5	32074304	32074304	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr5:32074304C>T	ENST00000438447.1	+	18	3480	c.3092C>T	c.(3091-3093)tCg>tTg	p.S1031L	PDZD2_ENST00000282493.3_Missense_Mutation_p.S1031L			O15018	PDZD2_HUMAN	PDZ domain containing 2	1031					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						AAGGCCATCTCGGCACCTCTT	0.567000													54	28					0	0	0.014410	0	0
SMTNL2	342527	broad.mit.edu	37	17	4496232	4496232	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr17:4496232G>A	ENST00000389313.4	+	3	563	c.496G>A	c.(496-498)Gat>Aat	p.D166N	SMTNL2_ENST00000338859.4_Missense_Mutation_p.D22N	NM_001114974.1	NP_001108446.1	Q2TAL5	SMTL2_HUMAN	smoothelin-like 2	166										breast(1)|endometrium(9)|kidney(1)|lung(1)|skin(1)	13				READ - Rectum adenocarcinoma(115;0.0325)		AGGTCCAGGCGATGGACCCCC	0.662000													31	19					0	0	0.027894	0	0
CROT	54677	broad.mit.edu	37	7	87011302	87011302	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr7:87011302G>C	ENST00000331536.3	+	11	1240	c.1055G>C	c.(1054-1056)aGa>aCa	p.R352T	CROT_ENST00000419147.2_Missense_Mutation_p.R380T|CROT_ENST00000442291.1_Missense_Mutation_p.R352T	NM_021151.3	NP_066974.2	Q9UKG9	OCTC_HUMAN	carnitine O-octanoyltransferase	352					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|transport	peroxisomal matrix	carnitine O-octanoyltransferase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)				L-Carnitine(DB00583)	AATGAAGGAAGATGGAAGGTA	0.303000													4	31					0	0	0.009096	0	0
FEM1A	55527	broad.mit.edu	37	19	4792857	4792857	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:4792857C>T	ENST00000269856.3	+	1	1130	c.991C>T	c.(991-993)Cag>Tag	p.Q331*	AC005523.2_ENST00000601192.1_RNA	NM_018708.2	NP_061178.1	Q9BSK4	FEM1A_HUMAN	fem-1 homolog a (C. elegans)	331					regulation of ubiquitin-protein ligase activity	cytoplasm	binding|ubiquitin-protein ligase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	17		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		GCTGCGTCACCAGGGGGGCGA	0.602000													22	40					0	0	0.027356	0	0
PPFIA4	8497	broad.mit.edu	37	1	203025554	203025554	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr1:203025554G>A	ENST00000367240.2	+	17	2622	c.2095G>A	c.(2095-2097)Gag>Aag	p.E699K	PPFIA4_ENST00000414050.2_Missense_Mutation_p.E427K|PPFIA4_ENST00000447715.2_Missense_Mutation_p.E698K|PPFIA4_ENST00000295706.4_Missense_Mutation_p.E214K|PPFIA4_ENST00000272198.6_Missense_Mutation_p.E214K|PPFIA4_ENST00000599966.1_Missense_Mutation_p.E214K			O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	214					cell communication	cell surface|cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|endometrium(6)|kidney(2)|large_intestine(8)|lung(20)|ovary(4)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	50						CATAAAATGTGAGACTTCTCC	0.577000													9	51					0	0	0.010729	0	0
NBEAL1	65065	broad.mit.edu	37	2	204058632	204058632	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr2:204058632G>C	ENST00000449802.1	+	46	7282	c.6949G>C	c.(6949-6951)Gag>Cag	p.E2317Q		NM_001114132.1	NP_001107604.1	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1	2317							binding			NS(1)|breast(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|liver(1)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						ATTTTTTATAGAGGTAATATC	0.308000													3	36					0	0	0.014758	0	0
ZNRD1-AS1	80862	broad.mit.edu	37	6	29977342	29977342	+	RNA	SNP	A	A	T	rs116382006	by1000genomes	TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr6:29977342A>T	ENST00000376797.3	-	0	731				ZNRD1-AS1_ENST00000448093.1_RNA|ZNRD1-AS1_ENST00000420251.1_RNA|HLA-J_ENST00000462773.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA																							TGGGACTGAGAGGCAAGATTT	0.438000													5	68					0	0	0.021553	0	0
RBP1	5947	broad.mit.edu	37	3	139236517	139236517	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr3:139236517C>T	ENST00000232219.2	-	4	656	c.546G>A	c.(544-546)atG>atA	p.M182I	RP11-319G6.1_ENST00000515247.1_RNA	NM_002899.3	NP_002890.2	P09455	RET1_HUMAN	retinol binding protein 1, cellular	120						cytoplasm	retinal binding|retinol binding|transporter activity			endometrium(1)|large_intestine(2)|lung(1)|prostate(1)	5					Vitamin A(DB00162)	CTTCCACTCTCATCTCCTGAA	0.488000													34	92					0	0	0.025465	0	0
TMEM5	10329	broad.mit.edu	37	12	64196067	64196067	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr12:64196067G>C	ENST00000261234.6	+	4	783	c.625G>C	c.(625-627)Gag>Cag	p.E209Q	TMEM5_ENST00000537373.1_5'UTR	NM_014254.1	NP_055069.1	Q9Y2B1	TMEM5_HUMAN	transmembrane protein 5	209						integral to plasma membrane				breast(1)|large_intestine(3)|liver(2)|lung(7)|prostate(1)|skin(1)	15		Myeloproliferative disorder(1001;0.0255)	BRCA - Breast invasive adenocarcinoma(9;0.0985)	GBM - Glioblastoma multiforme(28;9e-08)|BRCA - Breast invasive adenocarcinoma(357;0.000175)		TTGTGATAATGAGTGGATAAA	0.393000													8	36					0	0	0.006214	0	0
OSBPL8	114882	broad.mit.edu	37	12	76763454	76763454	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr12:76763454C>G	ENST00000261183.3	-	20	2682	c.2203G>C	c.(2203-2205)Gat>Cat	p.D735H	OSBPL8_ENST00000393250.4_Missense_Mutation_p.D693H|OSBPL8_ENST00000393249.2_Missense_Mutation_p.D693H	NM_020841.4	NP_065892.1	Q9BZF1	OSBL8_HUMAN	oxysterol binding protein-like 8	735					lipid transport		lipid binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(14)|ovary(2)	28						GTGAGTGGATCAAGTTCAAAT	0.358000													17	56					0	0	0.012319	0	0
SRC	6714	broad.mit.edu	37	20	36012632	36012632	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr20:36012632G>A	ENST00000373578.2	+	4	425	c.76G>A	c.(76-78)Ggc>Agc	p.G26S	SRC_ENST00000360723.4_Missense_Mutation_p.G26S|SRC_ENST00000445403.1_Missense_Mutation_p.G26S|SRC_ENST00000373558.2_Missense_Mutation_p.G26S|SRC_ENST00000358208.4_Missense_Mutation_p.G26S|SRC_ENST00000373567.2_Missense_Mutation_p.G26S	NM_198291.1	NP_938033.1	P12931	SRC_HUMAN	v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog	26					axon guidance|bone resorption|cell junction assembly|cellular membrane organization|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular protein kinase cascade|leukocyte migration|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of integrin activation|Ras protein signal transduction|regulation of bone resorption|regulation of vascular permeability|response to interleukin-1|signal complex assembly|T cell costimulation	caveola|cytosol|mitochondrial inner membrane	ATP binding|heme binding|integrin binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|SH3/SH2 adaptor activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(16)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	30		Myeloproliferative disorder(115;0.00878)			Dasatinib(DB01254)	GAACGTGCACGGCGCTGGCGG	0.741000													4	31					0	0	0.004482	0	0
IRS4	8471	broad.mit.edu	37	X	107977994	107977994	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chrX:107977994C>A	ENST00000372129.2	-	1	1657	c.1581G>T	c.(1579-1581)caG>caT	p.Q527H		NM_003604.2	NP_003595.1	O14654	IRS4_HUMAN	insulin receptor substrate 4	527						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(1)	78						CTCGGGATCCCTGTCCCTCGC	0.632000													17	133					1.10513e-12	1.2148e-12	0.014323	1	0
CD164L2	388611	broad.mit.edu	37	1	27706644	27706644	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr1:27706644C>T	ENST00000374027.3	-	5	478	c.415G>A	c.(415-417)Ggg>Agg	p.G139R	CD164L2_ENST00000374030.1_Missense_Mutation_p.G139R	NM_207397.2	NP_997280.1	Q6UWJ8	C16L2_HUMAN	CD164 sialomucin-like 2	139						integral to membrane				endometrium(1)|large_intestine(1)|lung(1)|urinary_tract(1)	4		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;2.89e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00128)|KIRC - Kidney renal clear cell carcinoma(1967;0.00155)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		AAGCTGGCCCCGTCAAATCCA	0.617000													5	93					0	0	0.003080	0	0
SHOX	6473	broad.mit.edu	37	X	591697	591697	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chrX:591697G>A	ENST00000381578.1	+	2	756	c.65G>A	c.(64-66)gGa>gAa	p.G22E	SHOX_ENST00000554971.1_Missense_Mutation_p.G22E|SHOX_ENST00000334060.3_Missense_Mutation_p.G22E|SHOX_ENST00000381575.1_Missense_Mutation_p.G22E	NM_000451.3	NP_000442.1	O15266	SHOX_HUMAN	short stature homeobox	22	Poly-Gly.				skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|lung(9)|prostate(1)	13		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GGTAACGGCGGAGGCGGAGGC	0.627000													5	220					0	0	0.014758	0	0
HIST1H2BO	8348	broad.mit.edu	37	6	27861555	27861555	+	Silent	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr6:27861555G>A	ENST00000303806.4	+	1	353	c.315G>A	c.(313-315)ggG>ggA	p.G105G		NM_003527.4	NP_003518.2	P23527	H2B1O_HUMAN	histone cluster 1, H2bo	105					nucleosome assembly	nucleosome|nucleus	DNA binding										TGCTGCCCGGGGAGCTGGCCA	0.642000													4	114					0	0	0.029380	0	0
WDR96	80217	broad.mit.edu	37	10	105948076	105948076	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr10:105948076C>T	ENST00000357060.3	-	13	1754	c.1639G>A	c.(1639-1641)Ggg>Agg	p.G547R	WDR96_ENST00000428666.1_Missense_Mutation_p.G548R|WDR96_ENST00000278064.2_Missense_Mutation_p.G478R	NM_025145.5	NP_079421.5	Q8NDM7	WDR96_HUMAN	WD repeat domain 96	547										NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(14)|lung(21)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						CTGCTTCTCCCTGCTTCTGGA	0.463000													3	46					0	0	0.004672	0	0
PBX2	5089	broad.mit.edu	37	6	32155525	32155525	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr6:32155525C>T	ENST00000375050.4	-	5	1039	c.769G>A	c.(769-771)Gag>Aag	p.E257K		NM_002586.4	NP_002577.2	P40425	PBX2_HUMAN	pre-B-cell leukemia homeobox 2	257							transcription factor binding			endometrium(1)|kidney(1)|lung(9)|ovary(1)|prostate(2)	14						TTTAGGACCTCAGTGGCCTGT	0.527000													7	19					0	0	0.003080	0	0
DOCK5	80005	broad.mit.edu	37	8	25174557	25174557	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr8:25174557C>G	ENST00000276440.7	+	14	1397	c.1353C>G	c.(1351-1353)atC>atG	p.I451M		NM_024940.6	NP_079216.4	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	451	DHR-1.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(9)|large_intestine(13)|lung(20)|ovary(3)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		TCACCCTGATCCACGGTGAGT	0.478000													3	53					0	0	0.004672	0	0
GDI1	2664	broad.mit.edu	37	X	153668396	153668396	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chrX:153668396C>T	ENST00000447750.2	+	5	832	c.497C>T	c.(496-498)aCc>aTc	p.T166I		NM_001493.2	NP_001484.1	P31150	GDIA_HUMAN	GDP dissociation inhibitor 1	166					protein transport|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|midbody	GTPase activator activity|protein binding			autonomic_ganglia(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	16	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCCCAGACTACCAGCATGCGT	0.552000													6	290					0	0	0.004482	0	0
DHX29	54505	broad.mit.edu	37	5	54586091	54586091	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr5:54586091G>C	ENST00000251636.5	-	7	1010	c.862C>G	c.(862-864)Caa>Gaa	p.Q288E	RP11-506H20.1_ENST00000506435.1_RNA	NM_019030.2	NP_061903.2	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	288							ATP binding|ATP-dependent helicase activity|translation initiation factor activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|lung(6)|ovary(4)|prostate(1)|skin(3)|urinary_tract(2)	46		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				TTTTGGCCTTGCTTGTTTTTT	0.328000													3	8					0	0	0.004672	0	0
DCBLD2	131566	broad.mit.edu	37	3	98531284	98531284	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr3:98531284T>C	ENST00000326840.6	-	10	1617	c.1255A>G	c.(1255-1257)Aac>Gac	p.N419D	DCBLD2_ENST00000326857.9_Missense_Mutation_p.N419D	NM_080927.3	NP_563615.3	Q96PD2	DCBD2_HUMAN	discoidin, CUB and LCCL domain containing 2	419	F5/8 type C.				cell adhesion|intracellular receptor mediated signaling pathway|negative regulation of cell growth|wound healing	cell surface|integral to plasma membrane				breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|stomach(2)	25						GGCAAAAAGTTATTACGCACA	0.348000													12	31					0	0	0.010729	0	0
HMGCLL1	54511	broad.mit.edu	37	6	55360317	55360317	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr6:55360317A>T	ENST00000398661.2	-	8	916	c.785T>A	c.(784-786)aTg>aAg	p.M262K	HMGCLL1_ENST00000370850.2_Missense_Mutation_p.M129K|HMGCLL1_ENST00000508459.1_Intron|HMGCLL1_ENST00000308161.4_Missense_Mutation_p.M200K|HMGCLL1_ENST00000274901.4_Missense_Mutation_p.M232K	NM_019036.2	NP_061909.2	Q8TB92	HMGC2_HUMAN	3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1	262							hydroxymethylglutaryl-CoA lyase activity|metal ion binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	31	Lung NSC(77;0.0875)		LUSC - Lung squamous cell carcinoma(124;0.23)			ACTTTCCAACATTCTTTTCAT	0.443000													17	44					0	0	0.007413	0	0
TFG	10342	broad.mit.edu	37	3	100463681	100463681	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr3:100463681G>C	ENST00000240851.4	+	7	1066	c.726G>C	c.(724-726)caG>caC	p.Q242H	TFG_ENST00000481203.1_3'UTR|TFG_ENST00000418917.2_Missense_Mutation_p.Q238H|TFG_ENST00000490574.1_Missense_Mutation_p.Q242H|TFG_ENST00000476228.1_Missense_Mutation_p.Q238H	NM_001195478.1|NM_001195479.1|NM_006070.5	NP_001182407.1|NP_001182408.1|NP_006061.2	Q92734	TFG_HUMAN	TRK-fused gene	242					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm	signal transducer activity		TFG/NR4A3(2)|TFG/NTRK1_ENST00000392302(5)|TFG/ALK(9)	large_intestine(4)|lung(2)|prostate(1)|stomach(1)	8						TTTCAGGTCAGATGTACCAAC	0.458000			T	"""NTRK1, ALK"""	"""papillary thyroid, ALCL, NSCLC"""								45	102					0	0	0.014410	0	0
ZNF493	284443	broad.mit.edu	37	19	21606712	21606712	+	Silent	SNP	T	T	C			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:21606712T>C	ENST00000392288.2	+	4	1360	c.1251T>C	c.(1249-1251)tcT>tcC	p.S417S	CTD-2561J22.3_ENST00000600810.1_Intron|ZNF493_ENST00000355504.4_Silent_p.S289S	NM_001076678.2	NP_001070146.1	Q6ZR52	ZN493_HUMAN	zinc finger protein 493	289					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	30						ATAAGGAGTCTTCACACCTTA	0.348000													4	35					0	0	0.014758	0	0
CRNN	49860	broad.mit.edu	37	1	152382700	152382700	+	Silent	SNP	A	A	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr1:152382700A>G	ENST00000271835.3	-	3	920	c.858T>C	c.(856-858)caT>caC	p.H286H	RP1-91G5.3_ENST00000411804.1_RNA	NM_016190.2	NP_057274.1	Q9UBG3	CRNN_HUMAN	cornulin	286	Gln-rich.				cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding	p.H286H(1)		breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTATCTGAGCATGTCCTCCTG	0.612000													7	513					0	0	0.003080	0	0
DOCK10	55619	broad.mit.edu	37	2	225651829	225651829	+	Silent	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr2:225651829G>A	ENST00000409592.3	-	50	5660	c.5547C>T	c.(5545-5547)gaC>gaT	p.D1849D	DOCK10_ENST00000258390.7_Silent_p.D1855D			Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1855	DHR-2.						GTP binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		ACCGATGAATGTCGTAGTAGA	0.403000													5	69					0	0	0.021553	0	0
UGT2B28	54490	broad.mit.edu	37	4	70160324	70160324	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr4:70160324T>A	ENST00000335568.5	+	6	1389	c.1387T>A	c.(1387-1389)Tgg>Agg	p.W463R	UGT2B28_ENST00000511240.1_3'UTR	NM_053039.1	NP_444267.1	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B28	463					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	31					Flunitrazepam(DB01544)	AGCAGTCTTCTGGATTGAATT	0.413000													33	79					0	0	0.033182	0	0
IRS4	8471	broad.mit.edu	37	X	107978050	107978050	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chrX:107978050C>T	ENST00000372129.2	-	1	1601	c.1525G>A	c.(1525-1527)Ggc>Agc	p.G509S		NM_003604.2	NP_003595.1	O14654	IRS4_HUMAN	insulin receptor substrate 4	509						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(1)	78						GAGCCTTGGCCATTTGAGCCC	0.597000													10	93					0	0	0.020292	0	0
TAS1R3	83756	broad.mit.edu	37	1	1268918	1268918	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr1:1268918G>T	ENST00000339381.5	+	6	1665	c.1633G>T	c.(1633-1635)Gag>Tag	p.E545*		NM_152228.1	NP_689414	Q7RTX0	TS1R3_HUMAN	taste receptor, type 1, member 3	545	Required for brazzein responsiveness.				detection of chemical stimulus involved in sensory perception of sweet taste|sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			kidney(2)|lung(8)|upper_aerodigestive_tract(1)|urinary_tract(1)	12	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.88e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.146)	Aspartame(DB00168)	TGGCCAGGATGAGTGGTCCCC	0.637000													22	60					1.88708e-17	2.10651e-17	0.037714	1	0
IKBKAP	8518	broad.mit.edu	37	9	111663910	111663910	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr9:111663910C>T	ENST00000374647.5	-	17	2213	c.1906G>A	c.(1906-1908)Gag>Aag	p.E636K	IKBKAP_ENST00000537196.1_Missense_Mutation_p.E287K	NM_003640.3	NP_003631.2	O95163	ELP1_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein	636					immune response|protein complex assembly|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding|signal transducer activity			NS(2)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						CTTGATACCTCAATGTCATTG	0.433000													16	51					0	0	0.007413	0	0
KCNQ2	3785	broad.mit.edu	37	20	62044922	62044922	+	Silent	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr20:62044922G>A	ENST00000354587.3	-	13	1736	c.1560C>T	c.(1558-1560)ttC>ttT	p.F520F	KCNQ2_ENST00000359125.2_Silent_p.F548F|KCNQ2_ENST00000344462.4_Silent_p.F517F|KCNQ2_ENST00000357249.2_Silent_p.F530F|KCNQ2_ENST00000359689.1_Silent_p.F548F|KCNQ2_ENST00000370224.1_Silent_p.F520F|KCNQ2_ENST00000360480.3_Silent_p.F520F			O43526	KCNQ2_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 2	548					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(4)|liver(1)|lung(30)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)	TGGACACCAGGAACCGCATGA	0.647000													30	85					0	0	0.013726	0	0
NUP210	23225	broad.mit.edu	37	3	13367407	13367407	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr3:13367407G>A	ENST00000254508.5	-	33	4614	c.4532C>T	c.(4531-4533)tCg>tTg	p.S1511L		NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa	1511					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					GCTGTTGGCCGAGGAGCTCCA	0.622000													14	76					0	0	0.010504	0	0
SLC16A14	151473	broad.mit.edu	37	2	230911105	230911105	+	Missense_Mutation	SNP	G	G	C	rs111627569		TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr2:230911105G>C	ENST00000295190.4	-	4	1195	c.737C>G	c.(736-738)aCa>aGa	p.T246R		NM_152527.4	NP_689740.2	Q7RTX9	MOT14_HUMAN	solute carrier family 16, member 14	246						integral to membrane|plasma membrane	symporter activity			NS(1)|cervix(1)|endometrium(7)|large_intestine(7)|lung(3)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		CTTCTCTTCTGTTCTTCCCTG	0.582000													5	106					0	0	0.029380	0	0
IRS4	8471	broad.mit.edu	37	X	107978105	107978105	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chrX:107978105C>G	ENST00000372129.2	-	1	1546	c.1470G>C	c.(1468-1470)atG>atC	p.M490I		NM_003604.2	NP_003595.1	O14654	IRS4_HUMAN	insulin receptor substrate 4	490						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(1)	78						CCCAATTGTTCATAGGCATGT	0.562000													9	82					0	0	0.016723	0	0
CCDC110	256309	broad.mit.edu	37	4	186379933	186379933	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr4:186379933C>T	ENST00000307588.3	-	6	1883	c.1808G>A	c.(1807-1809)gGa>gAa	p.G603E	CCDC110_ENST00000510617.1_Missense_Mutation_p.G603E|CCDC110_ENST00000393540.3_Missense_Mutation_p.G566E	NM_152775.3	NP_689988.1	Q8TBZ0	CC110_HUMAN	coiled-coil domain containing 110	603						nucleus				NS(1)|breast(1)|central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(9)	30		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;7.86e-05)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|Colorectal(36;0.0381)|all_hematologic(60;0.0749)		OV - Ovarian serous cystadenocarcinoma(60;1.13e-10)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.00014)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00921)|COAD - Colon adenocarcinoma(29;0.0105)|READ - Rectum adenocarcinoma(43;0.164)		TAGTTCATTTCCAAGTGAGCT	0.323000													11	21					0	0	0.016723	0	0
TCP10L2	401285	broad.mit.edu	37	6	167590518	167590518	+	Silent	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr6:167590518C>T	ENST00000366832.2	+	4	525	c.394C>T	c.(394-396)Ctg>Ttg	p.L132L		NM_001145121.1	NP_001138593.1	B9ZVM9	B9ZVM9_HUMAN	t-complex 10-like 2	132										endometrium(1)|kidney(2)|lung(3)	6						AATTTCACCTCTGTCAGCTGA	0.418000													12	43					0	0	0.008871	0	0
FAM162A	26355	broad.mit.edu	37	3	122126256	122126256	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr3:122126256C>T	ENST00000469967.1	+	4	460	c.392C>T	c.(391-393)tCt>tTt	p.S131F	FAM162A_ENST00000477892.1_Intron|FAM162A_ENST00000232125.5_Intron			Q96A26	F162A_HUMAN	family with sequence similarity 162, member A	0						integral to membrane				breast(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)	6						GGTTTCTTCTCTATCCAGTAT	0.438000													8	16					0	0	0.004482	0	0
IRS4	8471	broad.mit.edu	37	X	107978140	107978140	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chrX:107978140C>G	ENST00000372129.2	-	1	1511	c.1435G>C	c.(1435-1437)Gat>Cat	p.D479H		NM_003604.2	NP_003595.1	O14654	IRS4_HUMAN	insulin receptor substrate 4	479						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(1)	78						CCTTCCTGATCTTCTTTGCCC	0.577000													9	64					0	0	0.010729	0	0
ZNRD1-AS1	80862	broad.mit.edu	37	6	29977327	29977327	+	RNA	SNP	T	T	C	rs143365191	by1000genomes	TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr6:29977327T>C	ENST00000376797.3	-	0	731				ZNRD1-AS1_ENST00000448093.1_RNA|ZNRD1-AS1_ENST00000420251.1_RNA|HLA-J_ENST00000462773.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA																							GACAGCTGCCTTGTGTGGGAC	0.438000													5	65					0	0	0.021553	0	0
ZNF860	344787	broad.mit.edu	37	3	32032046	32032046	+	Missense_Mutation	SNP	G	G	A	rs143925165	by1000genomes	TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr3:32032046G>A	ENST00000360311.4	+	2	2024	c.1475G>A	c.(1474-1476)cGt>cAt	p.R492H		NM_001137674.2	NP_001131146.2	A6NHJ4	ZN860_HUMAN	zinc finger protein 860	492					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|lung(4)|ovary(1)	8						AAGACCTTCCGTCACAATTCA	0.403000													4	125					0	0	0.014758	0	0
GAREM	64762	broad.mit.edu	37	18	29848220	29848220	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr18:29848220C>T	ENST00000399218.4	-	6	2297	c.2242G>A	c.(2242-2244)Gat>Aat	p.D748N	GAREM_ENST00000269209.6_Missense_Mutation_p.D749N	NM_001242409.1|NM_022751.2	NP_001229338.1|NP_073588.1			GRB2 associated, regulator of MAPK1																		TCAGCACCATCAATTTTCAGA	0.522000													23	56					0	0	0.024334	0	0
NUDT16	131870	broad.mit.edu	37	3	131100691	131100691	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr3:131100691C>G	ENST00000521288.1	+	1	74	c.43C>G	c.(43-45)Ctg>Gtg	p.L15V	NUDT16_ENST00000502852.1_Missense_Mutation_p.L15V|NUDT16_ENST00000537561.1_Intron|NUDT16_ENST00000359850.3_5'UTR			Q96DE0	NUD16_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 16	15						nucleolus|nucleoplasm	hydrolase activity|metal ion binding|RNA binding			large_intestine(1)|lung(6)	7						GGCCCTGGCGCTGGGGTCGGG	0.706000													7	10					0	0	0.029380	0	0
TSPYL1	7259	broad.mit.edu	37	6	116600209	116600209	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr6:116600209C>G	ENST00000368608.3	-	1	857	c.785G>C	c.(784-786)cGa>cCa	p.R262P	DSE_ENST00000540275.1_Intron	NM_003309.3	NP_003300.1	Q9H0U9	TSYL1_HUMAN	TSPY-like 1	262					nucleosome assembly	nucleolus				breast(1)|endometrium(2)|large_intestine(2)|lung(2)|ovary(3)|urinary_tract(1)	11		all_cancers(87;0.0144)|all_epithelial(87;0.021)|Colorectal(196;0.234)		all cancers(137;0.0235)|OV - Ovarian serous cystadenocarcinoma(136;0.0469)|GBM - Glioblastoma multiforme(226;0.0503)|Epithelial(106;0.094)		CAGGTAGTGTCGACGCATCCG	0.567000													29	110					0	0	0.015359	0	0
NDUFA6	4700	broad.mit.edu	37	22	42486786	42486786	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr22:42486786C>G	ENST00000498737.2	-	1	173	c.41G>C	c.(40-42)tGc>tCc	p.C14S		NM_002490.3	NP_002481.2	P56556	NDUA6_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa	14					mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			kidney(1)|lung(3)|upper_aerodigestive_tract(1)	5					NADH(DB00157)	CACCCCTTTGCAAGCAGCGCG	0.622000											OREG0026602	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	212					0	0	0.003080	0	0
TUBA3C	7278	broad.mit.edu	37	13	19751303	19751303	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr13:19751303G>A	ENST00000400113.3	-	4	924	c.820C>T	c.(820-822)Ccg>Tcg	p.P274S		NM_006001.2	NP_005992.1	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	274					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(4)|prostate(7)|skin(7)|urinary_tract(1)	72		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		GAGATGACCGGGGCGTAGGTG	0.607000													49	173					0	0	0.014410	0	0
ACADSB	36	broad.mit.edu	37	10	124793889	124793889	+	Silent	SNP	G	G	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr10:124793889G>T	ENST00000358776.4	+	2	74	c.60G>T	c.(58-60)ctG>ctT	p.L20L	ACADSB_ENST00000368869.4_5'UTR|ACADSB_ENST00000496730.2_3'UTR	NM_001609.3	NP_001600.1	P45954	ACDSB_HUMAN	acyl-CoA dehydrogenase, short/branched chain	20					branched chain family amino acid catabolic process|fatty acid metabolic process	mitochondrial matrix	flavin adenine dinucleotide binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|lung(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	17		all_neural(114;0.0765)|Colorectal(57;0.102)|all_lung(145;0.11)|Lung NSC(174;0.163)		Colorectal(40;0.0811)|COAD - Colon adenocarcinoma(40;0.0835)	L-Isoleucine(DB00167)	GAAATTTCCTGACTTGTTTGT	0.353000													15	22					1.37522e-17	1.54713e-17	0.007413	1	0
MCHR2	84539	broad.mit.edu	37	6	100395738	100395738	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr6:100395738C>G	ENST00000281806.2	-	3	606	c.292G>C	c.(292-294)Gag>Cag	p.E98Q	MCHR2_ENST00000369212.2_Missense_Mutation_p.E98Q	NM_001040179.1	NP_001035269.1	Q969V1	MCHR2_HUMAN	melanin-concentrating hormone receptor 2	98						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	39		all_cancers(76;4.87e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0309)|Colorectal(196;0.069)		BRCA - Breast invasive adenocarcinoma(108;0.0429)		AACACCCACTCTCCCCCTCGG	0.493000													4	130					0	0	0.009096	0	0
GCNT4	51301	broad.mit.edu	37	5	74324587	74324587	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr5:74324587C>G	ENST00000322348.4	-	1	2137	c.1276G>C	c.(1276-1278)Gaa>Caa	p.E426Q		NM_016591.2	NP_057675.1	Q9P109	GCNT4_HUMAN	glucosaminyl (N-acetyl) transferase 4, core 2	426					protein O-linked glycosylation	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|ovary(2)|skin(1)|stomach(2)	19		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;8.44e-57)		TCAAGCTTTTCTGCCAAGCAT	0.373000													13	25					0	0	0.024245	0	0
EFCAB5	374786	broad.mit.edu	37	17	28380460	28380460	+	Silent	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr17:28380460G>A	ENST00000394835.3	+	10	1680	c.1488G>A	c.(1486-1488)caG>caA	p.Q496Q	EFCAB5_ENST00000541045.1_Silent_p.Q153Q|EFCAB5_ENST00000394832.2_Silent_p.Q496Q|EFCAB5_ENST00000536908.2_Silent_p.Q440Q|EFCAB5_ENST00000320856.5_Silent_p.Q496Q|EFCAB5_ENST00000378738.3_Silent_p.Q496Q	NM_198529.3	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5	496							calcium ion binding			breast(7)|endometrium(2)|kidney(4)|large_intestine(11)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	43						TTAACGAACAGAGAACATCAA	0.393000													12	41					0	0	0.020292	0	0
TEX2	55852	broad.mit.edu	37	17	62290518	62290518	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr17:62290518C>T	ENST00000258991.3	-	2	1144	c.1060G>A	c.(1060-1062)Gag>Aag	p.E354K	TEX2_ENST00000584379.1_Missense_Mutation_p.E354K|TEX2_ENST00000583097.1_Missense_Mutation_p.E354K			Q8IWB9	TEX2_HUMAN	testis expressed 2	354					signal transduction|sphingolipid metabolic process	integral to membrane				breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		CCATCCCCCTCAGAATCACAC	0.488000													19	67					0	0	0.021523	0	0
EGR2	1959	broad.mit.edu	37	10	64575663	64575663	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr10:64575663C>G	ENST00000242480.3	-	1	452	c.127G>C	c.(127-129)Gaa>Caa	p.E43Q	EGR2_ENST00000411732.1_5'UTR|EGR2_ENST00000493899.2_5'UTR|EGR2_ENST00000439032.1_Missense_Mutation_p.E43Q	NM_000399.3|NM_001136177.1	NP_000390.2|NP_001129649.1	P11161	EGR2_HUMAN	early growth response 2	43					fat cell differentiation|protein export from nucleus|transcription from RNA polymerase II promoter	cytoplasm|nucleus	chromatin binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(10)|lung(13)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)	36	Prostate(12;0.0297)|all_hematologic(501;0.228)					CCTCCCAGTTCGGCATTGGGA	0.622000													4	140					0	0	0.009096	0	0
MED13	9969	broad.mit.edu	37	17	60028189	60028189	+	Silent	SNP	A	A	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr17:60028189A>G	ENST00000397786.2	-	28	6364	c.6288T>C	c.(6286-6288)ctT>ctC	p.L2096L		NM_005121.2	NP_005112.2	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	2096					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(4)|central_nervous_system(1)|endometrium(10)|kidney(24)|large_intestine(15)|liver(1)|lung(20)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						GCAATACCTTAAGAAAAAGGG	0.413000													39	81					0	0	0.014410	0	0
CHAC1	79094	broad.mit.edu	37	15	41245807	41245807	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr15:41245807A>T	ENST00000446533.3	+	1	461	c.152A>T	c.(151-153)aAc>aTc	p.N51I	CHAC1_ENST00000444189.2_Missense_Mutation_p.N51I	NM_001142776.1|NM_024111.3	NP_001136248.1|NP_077016.2	Q9BUX1	CHAC1_HUMAN	ChaC, cation transport regulator homolog 1 (E. coli)	51					apoptosis in response to endoplasmic reticulum stress|response to unfolded protein	cytosol	protein binding			endometrium(1)|large_intestine(1)|skin(1)	3		all_cancers(109;1.42e-13)|all_epithelial(112;1.48e-11)|Lung NSC(122;5.77e-09)|all_lung(180;1.08e-07)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;2.66e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.163)		GCAGCCCCGAACACCCCGCCC	0.687000													13	60					0	0	0.010504	0	0
MSLNL	401827	broad.mit.edu	37	16	830490	830490	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr16:830490G>A	ENST00000293892.3	-	3	510	c.511C>T	c.(511-513)Cgc>Tgc	p.R171C	MSLNL_ENST00000442466.1_Intron			Q96KJ4	MSLNL_HUMAN	mesothelin-like	0					cell adhesion	integral to membrane		p.R171S(1)		breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(15)|ovary(2)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	36						GGATGCGTGCGGGCACGCATG	0.547000													5	190					0	0	0.021553	0	0
CSK	1445	broad.mit.edu	37	15	75094364	75094364	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr15:75094364G>T	ENST00000220003.9	+	12	1839	c.1110G>T	c.(1108-1110)tgG>tgT	p.W370C	CSK_ENST00000567571.1_Missense_Mutation_p.W370C|CSK_ENST00000309470.9_Missense_Mutation_p.W370C|CSK_ENST00000439220.2_Missense_Mutation_p.W370C	NM_004383.2	NP_004374.1	P41240	CSK_HUMAN	c-src tyrosine kinase	370	Protein kinase.				blood coagulation|epidermal growth factor receptor signaling pathway|T cell costimulation|T cell receptor signaling pathway	centrosome|cytosol|Golgi apparatus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein C-terminus binding			central_nervous_system(1)|lung(2)	3						CTGACGTGTGGAGTTTCGGAA	0.537000													27	52					2.87052e-16	3.17965e-16	0.023175	1	0
KLC2	64837	broad.mit.edu	37	11	66033397	66033397	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr11:66033397C>T	ENST00000394065.2	+	11	2117	c.1099C>T	c.(1099-1101)Cgc>Tgc	p.R367C	KLC2_ENST00000394066.2_Missense_Mutation_p.R429C|KLC2_ENST00000316924.5_Missense_Mutation_p.R506C|KLC2_ENST00000421552.1_Missense_Mutation_p.R429C|KLC2_ENST00000394067.2_Missense_Mutation_p.R506C|KLC2_ENST00000394078.1_Intron|KLC2_ENST00000417856.1_Missense_Mutation_p.R506C			Q9H0B6	KLC2_HUMAN	kinesin light chain 2	506					blood coagulation	cytosol|kinesin complex|microtubule	microtubule motor activity|protein binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	24						GGGAGACCGCCGCAGCAGCCG	0.667000													4	67					0	0	0.021553	0	0
CDH10	1008	broad.mit.edu	37	5	24491853	24491853	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr5:24491853C>G	ENST00000264463.4	-	11	2215	c.1708G>C	c.(1708-1710)Gac>Cac	p.D570H	CDH10_ENST00000502921.1_5'UTR	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	570	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		TAATCATTGTCTGATATCACC	0.413000										HNSCC(23;0.051)			3	45					0	0	0.004672	0	0
HAND2	9464	broad.mit.edu	37	4	174450071	174450071	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr4:174450071C>G	ENST00000359562.4	-	1	1309	c.370G>C	c.(370-372)Gag>Cag	p.E124Q	HAND2-AS1_ENST00000515310.1_RNA|HAND2-AS1_ENST00000512099.1_RNA|HAND2_ENST00000505300.1_5'UTR	NM_021973.2	NP_068808.1	P61296	HAND2_HUMAN	heart and neural crest derivatives expressed 2	124	Helix-loop-helix motif.				adult heart development|angiogenesis|apoptosis|cardiac neural crest cell development involved in outflow tract morphogenesis|heart looping|in utero embryonic development|negative regulation of cardiac muscle cell apoptosis|noradrenergic neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|regulation of secondary heart field cardioblast proliferation|thymus development	nuclear chromatin|transcription factor complex	activating transcription factor binding|protein homodimerization activity|RNA polymerase II regulatory region sequence-specific DNA binding|transcription coactivator activity			endometrium(1)|large_intestine(4)|lung(6)|prostate(1)|skin(1)	13		Prostate(90;0.00601)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_neural(102;0.0837)|all_hematologic(60;0.107)		all cancers(43;1.37e-18)|Epithelial(43;5.5e-17)|OV - Ovarian serous cystadenocarcinoma(60;3.3e-10)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		GGGATGCACTCGCGCAGTTCG	0.667000													44	131					0	0	0.014410	0	0
OTX2	5015	broad.mit.edu	37	14	57268797	57268797	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr14:57268797G>A	ENST00000339475.5	-	5	826	c.550C>T	c.(550-552)Ccc>Tcc	p.P184S	OTX2_ENST00000408990.3_Missense_Mutation_p.P176S|OTX2_ENST00000554788.1_3'UTR|OTX2_ENST00000554559.1_3'UTR|OTX2_ENST00000555006.1_Missense_Mutation_p.P176S	NM_001270523.1|NM_001270524.1|NM_001270525.1|NM_021728.3	NP_001257452.1|NP_001257453.1|NP_001257454.1|NP_068374.1	P32243	OTX2_HUMAN	orthodenticle homeobox 2	176					axon guidance|forebrain development|midbrain development|positive regulation of embryonic development|positive regulation of gastrulation|primitive streak formation|protein complex assembly|regulation of fibroblast growth factor receptor signaling pathway|regulation of smoothened signaling pathway	growth cone|nucleus|protein complex	eukaryotic initiation factor 4E binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|urinary_tract(1)	19	Medulloblastoma(1;0.00184)|all_neural(1;0.00414)					TAGGTCATGGGATAGGACCTC	0.522000													13	42					0	0	0.006122	0	0
PIGC	5279	broad.mit.edu	37	1	172410941	172410941	+	Silent	SNP	A	A	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr1:172410941A>G	ENST00000367728.1	-	1	2285	c.822T>C	c.(820-822)ctT>ctC	p.L274L	PIGC_ENST00000258324.1_Silent_p.L274L|PIGC_ENST00000484368.1_Intron|C1orf105_ENST00000367727.4_Intron|PIGC_ENST00000344529.4_Silent_p.L274L			Q92535	PIGC_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class C	274					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			breast(1)|endometrium(1)|kidney(1)|lung(1)	4						TTTCTTTAAAAAGCTGCAAGC	0.438000													17	57					0	0	0.006122	0	0
ZNF611	81856	broad.mit.edu	37	19	53209409	53209409	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:53209409G>T	ENST00000543227.1	-	6	1173	c.899C>A	c.(898-900)tCa>tAa	p.S300*	ZNF611_ENST00000319783.1_Nonsense_Mutation_p.S300*|ZNF611_ENST00000595798.1_Nonsense_Mutation_p.S231*|ZNF611_ENST00000540744.1_Nonsense_Mutation_p.S300*|ZNF611_ENST00000602162.1_Nonsense_Mutation_p.S231*|ZNF611_ENST00000453741.2_Nonsense_Mutation_p.S231*	NM_001161499.1	NP_001154971.1	Q8N823	ZN611_HUMAN	zinc finger protein 611	300					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|lung(12)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(262;0.0233)|GBM - Glioblastoma multiforme(134;0.04)		GGTAAGGGATGACTCCTGACT	0.413000													27	192					7.38237e-10	7.99294e-10	0.030593	1	0
REXO1L1	254958	broad.mit.edu	37	8	86574505	86574505	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr8:86574505C>A	ENST00000379010.2	-	1	1221	c.1222G>T	c.(1222-1224)Gac>Tac	p.D408Y		NM_172239.4	NP_758439.4	Q8IX06	GOR_HUMAN	REX1, RNA exonuclease 1 homolog (S. cerevisiae)-like 1	408	GOR1-125 epitope.					cytoplasm|nucleus	exonuclease activity|nucleic acid binding			endometrium(1)|lung(4)	5						CAGGAGGAGTCGCCGGGCCCC	0.672000													4	43					0.000602214	0.000628398	0.014758	1	0
DNAH10	196385	broad.mit.edu	37	12	124345688	124345688	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr12:124345688C>G	ENST00000409039.3	+	38	6550	c.6525C>G	c.(6523-6525)atC>atG	p.I2175M		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2175	AAA 2 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TCAGGGAAATCAACAAGCCAA	0.463000													7	30					0	0	0.004482	0	0
RB1	5925	broad.mit.edu	37	13	48947629	48947629	+	Splice_Site	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr13:48947629G>A	ENST00000267163.4	+	12	1353		c.e12+1			NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1						androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(23)|p.0?(15)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTATTTTAACGTAAGCCATAT	0.279000		6	"""D, Mis, N, F, S"""		"""retinoblastoma, sarcoma, breast, small cell lung"""	"""retinoblastoma, sarcoma, breast, small cell lung"""			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			17	29					0	0	0.033300	0	0
HIF1A	3091	broad.mit.edu	37	14	62211433	62211433	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr14:62211433C>A	ENST00000394997.1	+	13	2372	c.2107C>A	c.(2107-2109)Cct>Act	p.P703T	HIF1A_ENST00000539097.1_Missense_Mutation_p.P726T|HIF1A_ENST00000323441.6_Missense_Mutation_p.P702T|HIF1A_ENST00000337138.4_Missense_Mutation_p.P702T|HIF1A-AS2_ENST00000554254.1_lincRNA|HIF1A_ENST00000557538.1_Missense_Mutation_p.P643T|RP11-618G20.1_ENST00000555937.1_RNA			Q16665	HIF1A_HUMAN	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	702	ID.				cellular response to hypoxia|collagen metabolic process|connective tissue replacement involved in inflammatory response wound healing|elastin metabolic process|epithelial to mesenchymal transition|oxygen homeostasis|positive regulation of chemokine production|positive regulation of epithelial cell migration|positive regulation of hormone biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|regulation of transforming growth factor-beta2 production	cytoplasm|nucleolus|transcription factor complex	histone acetyltransferase binding|Hsp90 protein binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			breast(2)|endometrium(8)|kidney(6)|large_intestine(3)|lung(4)	23				OV - Ovarian serous cystadenocarcinoma(108;1.62e-09)|BRCA - Breast invasive adenocarcinoma(234;0.189)		AACTACAGTTCCTGAGGAAGA	0.308000													6	17					0.0215528	0.0221686	0.021553	1	0
DEPDC1B	55789	broad.mit.edu	37	5	59893730	59893730	+	Silent	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr5:59893730G>A	ENST00000265036.5	-	11	1507	c.1440C>T	c.(1438-1440)tcC>tcT	p.S480S	DEPDC1B_ENST00000545085.1_Silent_p.S391S|DEPDC1B_ENST00000453022.2_Silent_p.S418S	NM_018369.2	NP_060839.2	Q8WUY9	DEP1B_HUMAN	DEP domain containing 1B	480					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(2)|skin(2)	17		Lung NSC(810;0.000214)|Prostate(74;0.0147)|Breast(144;0.0991)|Ovarian(174;0.17)				CTTCAGGATAGGATTTCTGAA	0.383000													4	11					0	0	0.009096	0	0
KIF23	9493	broad.mit.edu	37	15	69709843	69709843	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr15:69709843A>G	ENST00000260363.4	+	3	320	c.203A>G	c.(202-204)tAt>tGt	p.Y68C	KIF23_ENST00000352331.4_Missense_Mutation_p.Y68C|KIF23_ENST00000559279.1_Missense_Mutation_p.Y68C|KIF23_ENST00000395392.2_Missense_Mutation_p.Y68C	NM_138555.2	NP_612565.1	Q02241	KIF23_HUMAN	kinesin family member 23	68	Kinesin-motor.				blood coagulation|cytokinesis|microtubule-based movement|mitosis|mitotic spindle elongation	cytosol|kinesin complex|microtubule|midbody|nucleoplasm|spindle	ATP binding|microtubule motor activity|protein binding			central_nervous_system(1)|endometrium(4)|large_intestine(7)|lung(6)|prostate(2)|skin(1)	21						AATGGAGACTATAAGGAGGTA	0.378000													33	75					0	0	0.030466	0	0
ZNF347	84671	broad.mit.edu	37	19	53644362	53644362	+	Silent	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:53644362C>T	ENST00000452676.2	-	5	2148	c.1722G>A	c.(1720-1722)gaG>gaA	p.E574E	ZNF347_ENST00000601804.1_Intron|ZNF347_ENST00000334197.7_Silent_p.E573E|ZNF347_ENST00000601469.2_Silent_p.E574E	NM_001172674.1	NP_001166145.1	Q96SE7	ZN347_HUMAN	zinc finger protein 347	573					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|prostate(3)|skin(1)	23				GBM - Glioblastoma multiforme(134;0.0179)		CCTTGCCACACTCATTACATT	0.408000													5	247					0	0	0.003080	0	0
ASPM	259266	broad.mit.edu	37	1	197059202	197059202	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr1:197059202C>T	ENST00000367409.4	-	25	10098	c.9842G>A	c.(9841-9843)aGa>aAa	p.R3281K	ASPM_ENST00000367408.1_Missense_Mutation_p.R946K|ASPM_ENST00000294732.7_Missense_Mutation_p.R1696K	NM_018136.4	NP_060606.3	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	3281					mitosis	cytoplasm|nucleus	calmodulin binding			breast(6)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(9)|large_intestine(28)|liver(1)|lung(87)|ovary(5)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(3)	165						TGGAGACAATCTAGTAACTAC	0.333000													14	37					0	0	0.006122	0	0
IER3	8870	broad.mit.edu	37	6	30712140	30712140	+	Silent	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr6:30712140G>A	ENST00000376377.2	-	1	185	c.156C>T	c.(154-156)ccC>ccT	p.P52P	IER3_ENST00000259874.5_Silent_p.P52P			P46695	IEX1_HUMAN	immediate early response 3	52					anatomical structure morphogenesis|anti-apoptosis|apoptosis	integral to membrane	protein binding			NS(1)	1						GAGAGGCGCTGGGGCGCCCGG	0.731000													3	7					0	0	0.004672	0	0
C9orf64	84267	broad.mit.edu	37	9	86571110	86571110	+	Silent	SNP	C	C	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr9:86571110C>A	ENST00000376344.3	-	1	522	c.306G>T	c.(304-306)ctG>ctT	p.L102L	C9orf64_ENST00000314700.1_5'UTR|C9orf64_ENST00000376340.2_5'UTR	NM_032307.3	NP_115683.3	Q5T6V5	CI064_HUMAN	chromosome 9 open reading frame 64	102										central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(8)|skin(1)	15						CGGCGGCGCACAGGGACCAGT	0.552000													30	137					3.66854e-30	4.22616e-30	0.030466	1	0
ZNF91	7644	broad.mit.edu	37	19	23544783	23544783	+	Missense_Mutation	SNP	C	C	T	rs410211		TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:23544783C>T	ENST00000300619.7	-	4	1203	c.998G>A	c.(997-999)cGt>cAt	p.R333H	ZNF91_ENST00000599743.1_Intron|ZNF91_ENST00000397082.2_Missense_Mutation_p.R301H	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	333				R -> H (in Ref. 1; AAA59469).		nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R333H(1)					all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				GGTTGAAGAACGGCTAAAAGC	0.393000													6	94					0	0	0.029380	0	0
ZNF282	8427	broad.mit.edu	37	7	148895819	148895819	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr7:148895819C>T	ENST00000262085.3	+	2	665	c.560C>T	c.(559-561)cCg>cTg	p.P187L	ZNF282_ENST00000479907.1_Missense_Mutation_p.P187L	NM_003575.2	NP_003566.1	Q9UDV7	ZN282_HUMAN	zinc finger protein 282	187					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(3)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	17	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)	Lung(243;0.145)		CGGCTGCCCCCGGGCAGCAAG	0.597000													10	64					0	0	0.016723	0	0
DNAH11	8701	broad.mit.edu	37	7	21695538	21695538	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr7:21695538G>C	ENST00000328843.6	+	29	5079	c.5048G>C	c.(5047-5049)gGa>gCa	p.G1683A	DNAH11_ENST00000409508.3_Missense_Mutation_p.G1678A			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1683	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						AGGGCAGTTGGAATGTACAGC	0.428000									Kartagener syndrome				4	35					0	0	0.009096	0	0
XPOT	11260	broad.mit.edu	37	12	64812728	64812728	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr12:64812728A>G	ENST00000332707.5	+	6	872	c.343A>G	c.(343-345)Aca>Gca	p.T115A		NM_007235.4	NP_009166.2	O43592	XPOT_HUMAN	exportin, tRNA	115	Necessary for interaction with Ran, nuclear localization and nuclear import.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding	p.T115A(2)		NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(7)|lung(12)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				GBM - Glioblastoma multiforme(28;0.0404)		GCTTTTTGTTACAGAGTATCT	0.433000													5	42					0	0	0.021553	0	0
KCTD16	57528	broad.mit.edu	37	5	143587001	143587001	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr5:143587001G>A	ENST00000507359.3	+	2	1815	c.724G>A	c.(724-726)Gag>Aag	p.E242K	KCTD16_ENST00000512467.1_Missense_Mutation_p.E242K	NM_020768.3	NP_065819.1	Q68DU8	KCD16_HUMAN	potassium channel tetramerization domain containing 16							cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(5)|lung(9)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	21		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)			TATGTTGTCAGAGTGTGGATT	0.428000													26	66					0	0	0.012213	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178772259	178772260	+	In_Frame_Ins	INS	-	-	GCA			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr5:178772259_178772260insGCA	ENST00000251582.7	-	1	171_172	c.70_71insTGC	c.(70-72)ccg>cTGCcg	p.23_24insL	ADAMTS2_ENST00000274609.5_In_Frame_Ins_p.23_24insL	NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	23					collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		gagcggcggcggcagcagcagc	0.812													5	4	---	---	---	---					
LINC01518	101929397	broad.mit.edu	37	10	43178879	43178879	+	RNA	DEL	G	G	-	rs141483266	by1000genomes	TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr10:43178879delG	ENST00000411439.1	-	0	284																											TTCAACGAGCGGGGGGACACT	0.473													2	4	---	---	---	---					
EFCAB4A	283229	broad.mit.edu	37	11	831640	831642	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr11:831640_831642delCTG	ENST00000525077.1	+	9	1232_1234	c.1131_1133delCTG	c.(1129-1134)acctgc>acc	p.C383del	EFCAB4A_ENST00000450448.1_3'UTR|EFCAB4A_ENST00000528542.2_3'UTR|AP006621.8_ENST00000532946.1_RNA			Q8N4Y2	EFC4A_HUMAN	EF-hand calcium binding domain 4A	383	Cys-rich.				store-operated calcium entry		calcium ion binding			endometrium(1)|large_intestine(1)|lung(1)	3		all_cancers(49;2.31e-08)|all_epithelial(84;3.72e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.179)|all_lung(207;0.227)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CTGGGCCCACCTGCTGCTGCTGC	0.695													3	5	---	---	---	---					
RP11-863P13.2	0	broad.mit.edu	37	16	88226611	88226611	+	RNA	DEL	G	G	-			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr16:88226611delG	ENST00000568587.1	-	0	91																											tggtggtgatggtggtgatgg	0.522													8	31	---	---	---	---