Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SLC17A5	26503	broad.mit.edu	37	6	74345112	74345112	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr6:74345112C>G	ENST00000355773.5	-	6	1080	c.812G>C	c.(811-813)aGa>aCa	p.R271T	SLC17A5_ENST00000393019.3_3'UTR|SLC17A5_ENST00000481996.1_5'UTR	NM_012434.4	NP_036566.1	Q9NRA2	S17A5_HUMAN	solute carrier family 17 (acidic sugar transporter), member 5	271			Missing (in ISSD).		anion transport	integral to plasma membrane|lysosomal membrane|membrane fraction	sialic acid:hydrogen symporter activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						TACCTGATTTCTTAATGATGA	0.274000													12	94					0	0	0.013537	0	0
WDR13	64743	broad.mit.edu	37	X	48460204	48460204	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chrX:48460204G>A	ENST00000218056.5	+	6	1369	c.864G>A	c.(862-864)atG>atA	p.M288I	WDR13_ENST00000376729.5_Missense_Mutation_p.M288I	NM_001166426.1|NM_017883.4	NP_001159898.1|NP_060353	Q9H1Z4	WDR13_HUMAN	WD repeat domain 13	288						cytoplasm|nucleus				endometrium(1)|large_intestine(4)|lung(4)|ovary(2)	11						TGCATGTCATGAACATCTCCA	0.602000													3	32					0	0	0.009096	0	0
NBPF10	100132406	broad.mit.edu	37	1	145302714	145302714	+	Silent	SNP	A	A	G	rs9424867		TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr1:145302714A>G	ENST00000342960.5	+	8	1187	c.1152A>G	c.(1150-1152)ttA>ttG	p.L384L	NBPF10_ENST00000369338.1_Silent_p.L113L|NBPF10_ENST00000369339.3_Silent_p.L113L|RP11-458D21.5_ENST00000468030.1_3'UTR	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	384								p.L113L(3)|p.L384L(3)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		AGGAGAAGTTACGGGAAGGGA	0.527000													6	184					0	0	0.029380	0	0
CHST2	9435	broad.mit.edu	37	3	142840871	142840871	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr3:142840871A>G	ENST00000309575.3	+	2	2597	c.1213A>G	c.(1213-1215)Acg>Gcg	p.T405A		NM_004267.4	NP_004258.2	Q9Y4C5	CHST2_HUMAN	carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2	405					inflammatory response|multicellular organismal development|N-acetylglucosamine metabolic process|sulfur compound metabolic process	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(12)|ovary(3)|prostate(2)	22						TATGGCTAAGACGCTGCAGAC	0.652000													4	63					0	0	0.009096	0	0
BPTF	2186	broad.mit.edu	37	17	65889808	65889808	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr17:65889808C>T	ENST00000321892.4	+	8	2817	c.2756C>T	c.(2755-2757)tCa>tTa	p.S919L	BPTF_ENST00000424123.3_Missense_Mutation_p.S780L|BPTF_ENST00000335221.5_Missense_Mutation_p.S919L|BPTF_ENST00000306378.6_Missense_Mutation_p.S793L			Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	919	Interaction with MAZ.				brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(23)|ovary(3)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	78	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			AACATCCCTTCATCCTTTCTT	0.368000													4	93					0	0	0.021553	0	0
FAT2	2196	broad.mit.edu	37	5	150920280	150920280	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr5:150920280C>G	ENST00000261800.5	-	10	8899	c.8887G>C	c.(8887-8889)Gag>Cag	p.E2963Q		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	2963	Cadherin 26.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATCCTCCACTCATCTCCAACT	0.527000													4	69					0	0	0.009096	0	0
FANCM	57697	broad.mit.edu	37	14	45658433	45658433	+	Silent	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr14:45658433G>C	ENST00000267430.5	+	20	5293	c.5208G>C	c.(5206-5208)ctG>ctC	p.L1736L	FANCM_ENST00000542564.2_Silent_p.L1710L	NM_020937.2	NP_065988.1	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	1736	Interaction with FAAP24 and EME1.				DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(31)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	85						AGACATCGCTGAATTTAAAGG	0.418000								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				19	237					0	0	0.010504	0	0
RNF125	54941	broad.mit.edu	37	18	29617078	29617078	+	Splice_Site	SNP	G	G	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr18:29617078G>T	ENST00000217740.3	+	2	656		c.e2-1		RP11-53I6.2_ENST00000583184.1_RNA	NM_017831.3	NP_060301.2	Q96EQ8	RN125_HUMAN	ring finger protein 125, E3 ubiquitin protein ligase						negative regulation of type I interferon production	intracellular	ligase activity|zinc ion binding			endometrium(1)|lung(4)|upper_aerodigestive_tract(1)	6						GTTTGGGGTAGATTCTGCCGT	0.418000													23	371					1.55469e-16	1.7729e-16	0.018920	1	0
RIMS2	9699	broad.mit.edu	37	8	104898276	104898276	+	Silent	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr8:104898276C>G	ENST00000507740.1	+	2	1109	c.873C>G	c.(871-873)ctC>ctG	p.L291L	RIMS2_ENST00000406091.3_Silent_p.L483L|RIMS2_ENST00000436393.2_Silent_p.L261L|RIMS2_ENST00000262231.10_Silent_p.L291L	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	514					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			ATGATTCTCTCAGTTCAGACC	0.438000										HNSCC(12;0.0054)			8	67					0	0	0.038147	0	0
ARHGAP19-SLIT1	100533184	broad.mit.edu	37	10	99025847	99025847	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr10:99025847G>C	ENST00000453547.2	-	2	91	c.92C>G	c.(91-93)tCt>tGt	p.S31C	ARHGAP19_ENST00000371027.1_Missense_Mutation_p.S22C|ARHGAP19_ENST00000358531.4_Missense_Mutation_p.S31C|ARHGAP19_ENST00000355366.5_Missense_Mutation_p.S22C|ARHGAP19-SLIT1_ENST00000358308.3_Missense_Mutation_p.S31C|ARHGAP19-SLIT1_ENST00000316676.8_Missense_Mutation_p.S31C														p.S31F(1)									TCGAAGGGAAGAATCATTGCA	0.393000													5	84					0	0	0.014758	0	0
FLG	2312	broad.mit.edu	37	1	152275618	152275618	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr1:152275618G>C	ENST00000368799.1	-	3	11779	c.11744C>G	c.(11743-11745)tCt>tGt	p.S3915C	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3915	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TACAGGTGAAGACTGTACATG	0.498000									Ichthyosis				5	101					0	0	0.029380	0	0
ZFR2	23217	broad.mit.edu	37	19	3819052	3819052	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr19:3819052T>C	ENST00000262961.4	-	12	1932	c.1922A>G	c.(1921-1923)gAc>gGc	p.D641G		NM_015174.1	NP_055989.1	Q9UPR6	ZFR2_HUMAN	zinc finger RNA binding protein 2	641						intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(5)|pancreas(1)|prostate(1)|skin(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00514)|STAD - Stomach adenocarcinoma(1328;0.19)		CCTGCGCTTGTCACCCTCTTC	0.682000													2	6					0	0	0.004672	0	0
ZNF429	353088	broad.mit.edu	37	19	21720683	21720683	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr19:21720683C>G	ENST00000358491.4	+	4	2036	c.1828C>G	c.(1828-1830)Caa>Gaa	p.Q610E	ZNF429_ENST00000597078.1_Intron	NM_001001415.2	NP_001001415.2	Q86V71	ZN429_HUMAN	zinc finger protein 429	610					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(13)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	34						AAGACTTACTCAACATAAGAA	0.358000													7	99					0	0	0.029380	0	0
INSIG1	3638	broad.mit.edu	37	7	155094081	155094081	+	Silent	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr7:155094081C>T	ENST00000340368.4	+	4	869	c.658C>T	c.(658-660)Cta>Tta	p.L220L	INSIG1_ENST00000344756.4_Silent_p.L68L|INSIG1_ENST00000342407.5_Intron	NM_005542.4	NP_005533.2	O15503	INSI1_HUMAN	insulin induced gene 1	220					cell proliferation|ER-nuclear sterol response pathway	endoplasmic reticulum membrane|integral to membrane	protein binding	p.L220V(1)		endometrium(2)|kidney(2)|large_intestine(1)|lung(11)|prostate(1)|upper_aerodigestive_tract(2)	19	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CATAGCTTTTCTAGCTACGCT	0.438000													9	107					0	0	0.006214	0	0
TSKU	25987	broad.mit.edu	37	11	76507357	76507357	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr11:76507357C>T	ENST00000527881.1	+	2	1723	c.697C>T	c.(697-699)Cac>Tac	p.H233Y	TSKU_ENST00000333090.4_Missense_Mutation_p.H233Y			Q8WUA8	TSK_HUMAN	tsukushi, small leucine rich proteoglycan	233						extracellular region				NS(1)|large_intestine(4)|lung(6)|urinary_tract(1)	12	Ovarian(111;0.112)					AGGCCTTACACACCTGTCTCT	0.667000													8	112					0	0	0.004482	0	0
MDC1	9656	broad.mit.edu	37	6	30670531	30670531	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr6:30670531C>T	ENST00000376406.3	-	13	6636	c.5989G>A	c.(5989-5991)Gag>Aag	p.E1997K	MDC1_ENST00000376405.2_Missense_Mutation_p.E1733K	NM_014641.2	NP_055456.2	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1997	BRCT 2.|Required for nuclear localization (NLS2).				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|kidney(1)|ovary(1)	4						CCTCTCACCTCTAGCAGCCTT	0.512000								Other conserved DNA damage response genes					13	196					0	0	0.020292	0	0
PSMD4	5710	broad.mit.edu	37	1	151238867	151238867	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr1:151238867G>C	ENST00000368884.3	+	8	927	c.847G>C	c.(847-849)Gag>Cag	p.E283Q	PSMD4_ENST00000368881.4_Missense_Mutation_p.E286Q	NM_002810.2	NP_002801.1	P55036	PSMD4_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4	283					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|lung(7)	11	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CAGTATGACTGAGGAAGAGCA	0.552000													12	99					0	0	0.013537	0	0
WHSC1L1	54904	broad.mit.edu	37	8	38173473	38173473	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr8:38173473C>G	ENST00000317025.8	-	10	2460	c.1943G>C	c.(1942-1944)aGa>aCa	p.R648T	WHSC1L1_ENST00000433384.2_Missense_Mutation_p.R648T|WHSC1L1_ENST00000527502.1_Missense_Mutation_p.R648T	NM_023034.1	NP_075447.1	Q9BZ95	NSD3_HUMAN	Wolf-Hirschhorn syndrome candidate 1-like 1	648					cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	24	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)			AGATGTGTCTCTGTATGCTGA	0.433000			T	NUP98	AML								6	166					0	0	0.021553	0	0
DEPDC7	91614	broad.mit.edu	37	11	33053051	33053051	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr11:33053051G>C	ENST00000311388.3	+	5	1259	c.883G>C	c.(883-885)Gat>Cat	p.D295H	DEPDC7_ENST00000241051.3_Missense_Mutation_p.D304H	NM_139160.2	NP_631899.2	Q96QD5	DEPD7_HUMAN	DEP domain containing 7	304					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			endometrium(2)|large_intestine(4)|lung(8)|ovary(1)|skin(2)	17						ACTTCTGTTTGATGCCATTGG	0.398000													10	124					0	0	0.024245	0	0
PVRL3	25945	broad.mit.edu	37	3	110845149	110845149	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr3:110845149C>T	ENST00000485303.1	+	5	1311	c.1036C>T	c.(1036-1038)Caa>Taa	p.Q346*	PVRL3_ENST00000319792.3_Nonsense_Mutation_p.Q346*|PVRL3_ENST00000493615.1_Nonsense_Mutation_p.Q323*	NM_001243286.1|NM_015480.2	NP_001230215.1|NP_056295.1	Q9NQS3	PVRL3_HUMAN	poliovirus receptor-related 3	346	Ig-like C2-type 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane	cell adhesion molecule binding|protein homodimerization activity			breast(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(3)	19						TTCCCTTGGTCAAAGAAGTGA	0.313000													5	62					0	0	0.021553	0	0
TEX37	200523	broad.mit.edu	37	2	88828645	88828645	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:88828645G>C	ENST00000303254.3	+	4	338	c.196G>C	c.(196-198)Gat>Cat	p.D66H		NM_152670.2	NP_689883.1			testis expressed 37																		CAAGCTAACAGATGGGTACCC	0.532000													8	84					0	0	0.004482	0	0
PM20D1	148811	broad.mit.edu	37	1	205819093	205819093	+	Silent	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr1:205819093C>T	ENST00000367136.4	-	1	152	c.108G>A	c.(106-108)gcG>gcA	p.A36A	PM20D1_ENST00000460624.1_5'UTR	NM_152491.4	NP_689704.4	Q6GTS8	P20D1_HUMAN	peptidase M20 domain containing 1	36						extracellular region	metal ion binding|peptidase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(1)	28	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0252)			GGATTCGCGACGCCCTTTGAT	0.592000													5	58					0	0	0.014758	0	0
TSSC2	650368	broad.mit.edu	37	11	3427765	3427765	+	RNA	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr11:3427765G>C	ENST00000529482.1	+	0	882																											CACACGTCCTGCAGTGGCCTG	0.602000													3	32					0	0	0.004672	0	0
EZR	7430	broad.mit.edu	37	6	159191809	159191809	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr6:159191809C>G	ENST00000367075.3	-	10	1245	c.1077G>C	c.(1075-1077)aaG>aaC	p.K359N	EZR_ENST00000392177.4_Missense_Mutation_p.K327N|EZR_ENST00000337147.7_Missense_Mutation_p.K359N	NM_001111077.1	NP_001104547.1	P15311	EZRI_HUMAN	ezrin	359	Interaction with SCYL3.				actin filament bundle assembly|axon guidance|cytoskeletal anchoring at plasma membrane|leukocyte cell-cell adhesion|membrane to membrane docking|regulation of cell shape	actin filament|apical plasma membrane|basolateral plasma membrane|cortical cytoskeleton|cytosol|extrinsic to membrane|filopodium|microvillus membrane|nucleolus|ruffle membrane	actin filament binding|cell adhesion molecule binding		EZR/ROS1(4)	breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(2)|lung(1)|ovary(1)|prostate(2)	15		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-17)|BRCA - Breast invasive adenocarcinoma(81;6.58e-06)		TCTCTGCCTTCTTTGTCTTCT	0.567000			T	ROS1	NSCLC								10	149					0	0	0.008291	0	0
NCR1	9437	broad.mit.edu	37	19	55420628	55420628	+	Missense_Mutation	SNP	C	C	T	rs142626797		TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr19:55420628C>T	ENST00000594765.1	+	4	405	c.380C>T	c.(379-381)tCg>tTg	p.S127L	NCR1_ENST00000350790.5_Missense_Mutation_p.S32L|NCR1_ENST00000357397.5_Missense_Mutation_p.S20L|NCR1_ENST00000338835.5_Missense_Mutation_p.S127L|NCR1_ENST00000598576.1_Missense_Mutation_p.S115L|NCR1_ENST00000447255.1_Missense_Mutation_p.S127L|NCR1_ENST00000291890.4_Missense_Mutation_p.S127L			O76036	NCTR1_HUMAN	natural cytotoxicity triggering receptor 1	127					cellular defense response|natural killer cell activation|regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane|SWI/SNF complex	receptor activity|receptor signaling protein activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)	18				GBM - Glioblastoma multiforme(193;0.0449)		CCCACCCTCTCGGTTCATCCT	0.483000													5	88					0	0	0.021553	0	0
ZNF615	284370	broad.mit.edu	37	19	52496411	52496411	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr19:52496411T>C	ENST00000602063.1	-	6	2267	c.1918A>G	c.(1918-1920)Ata>Gta	p.I640V	ZNF615_ENST00000598071.1_Missense_Mutation_p.I651V|ZNF615_ENST00000391795.3_Missense_Mutation_p.I645V|ZNF615_ENST00000594083.1_Missense_Mutation_p.I651V|ZNF615_ENST00000376716.5_Missense_Mutation_p.I640V			Q8N8J6	ZN615_HUMAN	zinc finger protein 615	640					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(5)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	42		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		TGATGTTGTATGAGGCATGTC	0.378000													16	308					0	0	0.024245	0	0
ARHGAP10	79658	broad.mit.edu	37	4	148743974	148743974	+	Splice_Site	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr4:148743974G>A	ENST00000336498.3	+	2	489		c.e2+1			NM_024605.3	NP_078881.3	A1A4S6	RHG10_HUMAN	Rho GTPase activating protein 10						apoptosis|filopodium assembly|regulation of apoptosis|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm|plasma membrane	cytoskeletal adaptor activity|SH3 domain binding			autonomic_ganglia(2)|endometrium(5)|kidney(2)|large_intestine(4)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	33	all_hematologic(180;0.151)	Renal(17;0.0166)		GBM - Glioblastoma multiforme(119;0.0423)		CGATGCATAGGTAATTAAACA	0.393000													4	152					0	0	0.009096	0	0
ZNF609	23060	broad.mit.edu	37	15	64968069	64968069	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr15:64968069G>A	ENST00000326648.3	+	4	3144	c.3016G>A	c.(3016-3018)Gaa>Aaa	p.E1006K		NM_015042.1	NP_055857.1	O15014	ZN609_HUMAN	zinc finger protein 609	1006						nucleus	zinc ion binding			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GCAGCAGTACGAAGAACAGCA	0.562000													4	115					0	0	0.014758	0	0
TEX15	56154	broad.mit.edu	37	8	30702398	30702398	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr8:30702398C>G	ENST00000256246.2	-	1	4210	c.4136G>C	c.(4135-4137)aGa>aCa	p.R1379T		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	1379										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		CTCTTTTTCTCTACAGCTCTG	0.398000													6	174					0	0	0.029380	0	0
MLXIPL	51085	broad.mit.edu	37	7	73010266	73010266	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr7:73010266C>G	ENST00000313375.3	-	14	2139	c.2092G>C	c.(2092-2094)Gag>Cag	p.E698Q	MLXIPL_ENST00000434326.1_Missense_Mutation_p.E604Q|MLXIPL_ENST00000414749.2_Missense_Mutation_p.E696Q|MLXIPL_ENST00000429400.2_Intron|MLXIPL_ENST00000395189.1_Missense_Mutation_p.E605Q|MLXIPL_ENST00000354613.1_Intron	NM_032951.2|NM_032953.2	NP_116569.1|NP_116571.1	Q9NP71	WBS14_HUMAN	MLX interacting protein-like	698	Helix-loop-helix motif.				anatomical structure morphogenesis|energy reserve metabolic process|glucose mediated signaling pathway|intracellular protein kinase cascade|negative regulation of cell cycle arrest|negative regulation of oxidative phosphorylation|negative regulation of peptidyl-serine phosphorylation|positive regulation of cell proliferation|positive regulation of fatty acid biosynthetic process|positive regulation of glycolysis|positive regulation of transcription from RNA polymerase II promoter|triglyceride homeostasis	cytosol|transcription factor complex	carbohydrate response element binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			cervix(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	13		Lung NSC(55;0.0659)|all_lung(88;0.152)				AGGATGTACTCAGCTGTCTTC	0.607000													4	26					0	0	0.014758	0	0
SCTR	6344	broad.mit.edu	37	2	120197742	120197742	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:120197742G>A	ENST00000019103.5	-	13	1541	c.1274C>T	c.(1273-1275)gCc>gTc	p.A425V		NM_002980.2	NP_002971.2	P47872	SCTR_HUMAN	secretin receptor	425					digestion|excretion	integral to plasma membrane	secretin receptor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(3)	19					Secretin(DB00021)	CAAGTGGCTGGCCTTGGTGCT	0.627000													5	24					0	0	0.014758	0	0
ZNF429	353088	broad.mit.edu	37	19	21720336	21720336	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr19:21720336C>G	ENST00000358491.4	+	4	1689	c.1481C>G	c.(1480-1482)tCa>tGa	p.S494*	ZNF429_ENST00000597078.1_Intron	NM_001001415.2	NP_001001415.2	Q86V71	ZN429_HUMAN	zinc finger protein 429	494					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(13)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	34						AAGCAGTCCTCAAACCTTAAC	0.398000													9	59					0	0	0.004482	0	0
PRSS45	377047	broad.mit.edu	37	3	46783844	46783844	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr3:46783844G>A	ENST00000442359.2	-	4	682	c.683C>T	c.(682-684)tCc>tTc	p.S228F	PRSS50_ENST00000460241.1_Intron	NM_199183.2	NP_954652.2	Q7RTY3	PRS45_HUMAN	protease, serine, 45	260	Peptidase S1.				proteolysis		serine-type endopeptidase activity			kidney(1)|large_intestine(1)|lung(2)|prostate(1)	5						GGGAGGTCAGGAGCCCATCTG	0.552000													7	168					0	0	0.038147	0	0
ERF	2077	broad.mit.edu	37	19	42754675	42754675	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr19:42754675G>C	ENST00000222329.4	-	2	222	c.65C>G	c.(64-66)cCt>cGt	p.P22R	AC006486.9_ENST00000594664.1_Intron|ERF_ENST00000595941.1_5'UTR|ERF_ENST00000440177.2_5'UTR	NM_006494.2	NP_006485.2	P50548	ERF_HUMAN	Ets2 repressor factor	22					cell proliferation|regulation of transcription from RNA polymerase II promoter	nucleus	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(7)|skin(1)	17		Prostate(69;0.00682)				CCTTGAGCCAGGGGACGACTC	0.642000													4	37					0	0	0.009096	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													3	77					0	0	0.004672	0	0
LRRC7	57554	broad.mit.edu	37	1	70504020	70504020	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr1:70504020G>A	ENST00000310961.5	+	22	2832	c.2414G>A	c.(2413-2415)aGa>aAa	p.R805K	LRRC7_ENST00000415775.2_Missense_Mutation_p.R84K|LRRC7_ENST00000035383.5_Missense_Mutation_p.R800K			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	800						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						TCGAAATCTAGAAGCACATCT	0.488000													11	181					0	0	0.010729	0	0
MED13	9969	broad.mit.edu	37	17	60028354	60028354	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr17:60028354C>G	ENST00000397786.2	-	28	6199	c.6123G>C	c.(6121-6123)caG>caC	p.Q2041H		NM_005121.2	NP_005112.2	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	2041					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(4)|central_nervous_system(1)|endometrium(10)|kidney(24)|large_intestine(15)|liver(1)|lung(20)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						GATCAGTACTCTGACCCTTAA	0.373000													7	98					0	0	0.004482	0	0
MYOF	26509	broad.mit.edu	37	10	95147619	95147619	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr10:95147619G>A	ENST00000371501.4	-	19	1755	c.1633C>T	c.(1633-1635)Ctt>Ttt	p.L545F	MYOF_ENST00000371502.4_Missense_Mutation_p.L545F|MYOF_ENST00000359263.4_Missense_Mutation_p.L545F|MYOF_ENST00000358334.5_Missense_Mutation_p.L532F			Q9NZM1	MYOF_HUMAN	myoferlin	545					blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			NS(2)|autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(7)|large_intestine(15)|lung(14)|ovary(4)|prostate(4)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						GTCTTCTCAAGAAAAGTGGCT	0.423000													6	166					0	0	0.038147	0	0
LAMP3	27074	broad.mit.edu	37	3	182853541	182853541	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr3:182853541G>C	ENST00000265598.3	-	5	1336	c.1081C>G	c.(1081-1083)Caa>Gaa	p.Q361E	LAMP3_ENST00000466939.1_Missense_Mutation_p.Q337E	NM_014398.3	NP_055213.2	Q9UQV4	LAMP3_HUMAN	lysosomal-associated membrane protein 3	361					cell proliferation	integral to membrane|lysosomal membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(9)|ovary(2)|prostate(2)	28	all_cancers(143;9.14e-14)|Ovarian(172;0.0355)		all cancers(12;2.91e-44)|Epithelial(37;5.52e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;4.16e-21)			TCAAAGGCTTGAAGTTGGACA	0.478000													26	297					0	0	0.021523	0	0
F2R	2149	broad.mit.edu	37	5	76028929	76028929	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr5:76028929C>G	ENST00000319211.4	+	2	1144	c.879C>G	c.(877-879)atC>atG	p.I293M		NM_001992.3	NP_001983.2	P25116	PAR1_HUMAN	coagulation factor II (thrombin) receptor	293					activation of caspase activity|anatomical structure morphogenesis|connective tissue replacement involved in inflammatory response wound healing|negative regulation of cell proliferation|platelet activation|positive regulation of blood coagulation|positive regulation of cell migration|positive regulation of collagen biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JAK-STAT cascade|positive regulation of MAPKKK cascade|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of transcription, DNA-dependent|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	caveola|extracellular region|Golgi apparatus|integral to plasma membrane|platelet dense tubular network	receptor binding|thrombin receptor activity	p.I293I(1)		NS(1)|breast(1)|endometrium(3)|kidney(1)|lung(7)|ovary(3)	16		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Prostate(461;0.00955)|Ovarian(174;0.0129)		all cancers(79;4.43e-43)	Streptokinase(DB00086)	ATGTGTCTATCATTCGATGTC	0.483000													8	137					0	0	0.038147	0	0
ADAT1	23536	broad.mit.edu	37	16	75654613	75654613	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr16:75654613G>A	ENST00000307921.3	-	3	230	c.85C>T	c.(85-87)Cat>Tat	p.H29Y		NM_012091.3	NP_036223.2	Q9BUB4	ADAT1_HUMAN	adenosine deaminase, tRNA-specific 1	29					tRNA processing		metal ion binding|RNA binding|tRNA-specific adenosine deaminase activity			breast(1)|endometrium(4)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(1)|stomach(1)	19						GTCCACTCATGGTTTGGCTCA	0.522000													6	67					0	0	0.021553	0	0
PRAMEF2	65122	broad.mit.edu	37	1	12921316	12921316	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr1:12921316C>G	ENST00000240189.2	+	4	1194	c.1107C>G	c.(1105-1107)atC>atG	p.I369M		NM_023014.1	NP_075390.1	O60811	PRAM2_HUMAN	PRAME family member 2	369										breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(22)|prostate(6)|skin(3)|upper_aerodigestive_tract(4)	42	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TCAGTGCCATCCTGCCTGGCC	0.562000													7	187					0	0	0.038147	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54912718	54912718	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr12:54912718G>C	ENST00000293373.6	+	15	1520	c.1441G>C	c.(1441-1443)Gaa>Caa	p.E481Q	NCKAP1L_ENST00000545638.2_Missense_Mutation_p.E431Q	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	481					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						AGAAAAATTTGAATTCTCAGG	0.403000													8	72					0	0	0.004482	0	0
C7orf60	154743	broad.mit.edu	37	7	112472660	112472660	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr7:112472660C>G	ENST00000297145.4	-	4	709	c.544G>C	c.(544-546)Gaa>Caa	p.E182Q	C7orf60_ENST00000485446.1_5'UTR	NM_152556.2	NP_689769.2	Q1RMZ1	CG060_HUMAN	chromosome 7 open reading frame 60	182										breast(1)|endometrium(2)|lung(7)|ovary(3)|prostate(2)|skin(1)|urinary_tract(1)	17						AGAAATTCTTCAAACTTCAGA	0.308000													6	133					0	0	0.029380	0	0
GRASP	160622	broad.mit.edu	37	12	52404711	52404711	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr12:52404711G>C	ENST00000293662.4	+	3	423	c.343G>C	c.(343-345)Gag>Cag	p.E115Q	GRASP_ENST00000552049.1_5'UTR|GRASP_ENST00000552963.1_3'UTR	NM_181711.2	NP_859062.1	Q7Z6J2	GRASP_HUMAN	GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein	115	PDZ.					cell junction|perinuclear region of cytoplasm|postsynaptic membrane				central_nervous_system(1)|large_intestine(1)|lung(1)|skin(2)	5				BRCA - Breast invasive adenocarcinoma(357;0.0967)		CTTCGGCTTTGAGATCCAGGT	0.547000													11	134					0	0	0.010729	0	0
SMARCAD1	56916	broad.mit.edu	37	4	95129666	95129666	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr4:95129666G>A	ENST00000354268.4	+	2	194	c.121G>A	c.(121-123)Gaa>Aaa	p.E41K	SMARCAD1_ENST00000457823.2_Missense_Mutation_p.E41K			Q9H4L7	SMRCD_HUMAN	SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1	41					chromatin modification|nucleotide metabolic process|positive regulation of transcription, DNA-dependent|protein homooligomerization|regulation of DNA recombination	nuclear matrix	ATP binding|DNA binding|helicase activity			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|liver(2)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	44				OV - Ovarian serous cystadenocarcinoma(123;4.33e-08)		TCTTAGTGCTGAAGAGGAGAA	0.438000													7	127					0	0	0.006214	0	0
RLBP1	6017	broad.mit.edu	37	15	89758326	89758326	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr15:89758326C>G	ENST00000268125.5	-	6	929	c.490G>C	c.(490-492)Gag>Cag	p.E164Q		NM_000326.4	NP_000317.1	P12271	RLBP1_HUMAN	retinaldehyde binding protein 1	164	CRAL-TRIO.				response to stimulus|visual perception|vitamin A metabolic process	cytoplasm|soluble fraction	retinol binding|transporter activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(1)|prostate(1)|skin(1)	18	Lung NSC(78;0.0472)|all_lung(78;0.089)				Vitamin A(DB00162)	TGCCAGTTCTCAATGTTGAAG	0.577000													7	121					0	0	0.038147	0	0
HRG	3273	broad.mit.edu	37	3	186383944	186383944	+	Nonsense_Mutation	SNP	C	C	T	rs146244921	by1000genomes	TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr3:186383944C>T	ENST00000232003.4	+	1	204	c.124C>T	c.(124-126)Cga>Tga	p.R42*	HRG_ENST00000468154.1_3'UTR	NM_000412.2	NP_000403.1	P04196	HRG_HUMAN	histidine-rich glycoprotein	42	Cystatin 1.|Interaction with ATP5A1.				fibrinolysis|platelet activation|platelet degranulation	extracellular region|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(12)|lung(13)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0683)		CAATAAAAGGCGACGGGATGG	0.512000													9	82					0	0	0.004482	0	0
POLE2	5427	broad.mit.edu	37	14	50118050	50118050	+	Silent	SNP	T	T	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr14:50118050T>C	ENST00000539565.2	-	15	1397	c.1179A>G	c.(1177-1179)ttA>ttG	p.L393L	POLE2_ENST00000554396.1_Silent_p.L419L|POLE2_ENST00000216367.5_Silent_p.L419L|POLE2_ENST00000556584.1_5'UTR	NM_001197330.1	NP_001184259.1	P56282	DPOE2_HUMAN	polymerase (DNA directed), epsilon 2, accessory subunit	419					DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	DNA binding|DNA-directed DNA polymerase activity			kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	10	all_epithelial(31;0.0021)|Breast(41;0.0124)					TTTTATTTACTAAGTCTTCAC	0.323000													5	66					0	0	0.021553	0	0
CTPS1	1503	broad.mit.edu	37	1	41471729	41471729	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr1:41471729A>G	ENST00000372621.4	+	13	1767	c.1259A>G	c.(1258-1260)aAt>aGt	p.N420S	CTPS1_ENST00000541520.1_Missense_Mutation_p.N189S|CTPS1_ENST00000372616.1_Missense_Mutation_p.N420S	NM_001905.2	NP_001896.2	P17812	PYRG1_HUMAN	CTP synthase 1	420	Glutamine amidotransferase type-1.				CTP biosynthetic process|glutamine metabolic process|nucleobase, nucleoside and nucleotide interconversion|response to drug	cytosol	ATP binding|CTP synthase activity|protein binding			endometrium(3)|lung(10)	13					L-Glutamine(DB00130)	TCAGATGCCAATTCTACAGAG	0.408000													3	119					0	0	0.004672	0	0
MSI2	124540	broad.mit.edu	37	17	55674294	55674294	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr17:55674294G>A	ENST00000284073.2	+	8	729	c.520G>A	c.(520-522)Gaa>Aaa	p.E174K	MSI2_ENST00000579180.1_Missense_Mutation_p.E70K|MSI2_ENST00000322684.3_Missense_Mutation_p.E170K|MSI2_ENST00000579505.1_3'UTR|MSI2_ENST00000442934.2_Missense_Mutation_p.E113K|MSI2_ENST00000416426.2_Missense_Mutation_p.E152K	NM_138962.2	NP_620412.1	Q96DH6	MSI2H_HUMAN	musashi RNA-binding protein 2	174	RRM 2.					cytoplasm	nucleotide binding|RNA binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(1)|pancreas(1)|skin(1)	7	Breast(9;1.78e-08)			GBM - Glioblastoma multiforme(1;0.0025)		TCATTTCCATGAAATCAATAA	0.418000			T	HOXA9	CML								5	113					0	0	0.014758	0	0
STYK1	55359	broad.mit.edu	37	12	10780303	10780303	+	Silent	SNP	A	A	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr12:10780303A>C	ENST00000075503.3	-	7	1174	c.654T>G	c.(652-654)ggT>ggG	p.G218G		NM_018423.2	NP_060893.2	Q6J9G0	STYK1_HUMAN	serine/threonine/tyrosine kinase 1	218	Protein kinase.					integral to membrane|plasma membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|liver(1)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	26						CATAGAGAAGACCATCCATAG	0.398000										HNSCC(73;0.22)			9	72					0	0	0.016723	0	0
FAM47A	158724	broad.mit.edu	37	X	34149795	34149795	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chrX:34149795G>A	ENST00000346193.3	-	1	652	c.601C>T	c.(601-603)Cca>Tca	p.P201S		NM_203408.3	NP_981953.2	Q5JRC9	FA47A_HUMAN	family with sequence similarity 47, member A	201	Pro-rich.									NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(9)|kidney(5)|large_intestine(17)|lung(44)|ovary(5)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	97						GGAGGCTCTGGGAGGAGATGG	0.617000													3	64					0	0	0.004672	0	0
SAMD9	54809	broad.mit.edu	37	7	92734318	92734318	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr7:92734318C>G	ENST00000379958.2	-	3	1362	c.1093G>C	c.(1093-1095)Gat>Cat	p.D365H		NM_001193307.1|NM_017654.3	NP_001180236.1|NP_060124.2	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	365						cytoplasm				NS(1)|breast(4)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(20)|lung(32)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	88	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			GTTTTAAAATCTGCTTTAAAT	0.333000													9	188					0	0	0.008291	0	0
BUB1	699	broad.mit.edu	37	2	111427076	111427076	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:111427076G>C	ENST00000535254.1	-	5	528	c.461C>G	c.(460-462)tCa>tGa	p.S154*	BUB1_ENST00000409311.1_Nonsense_Mutation_p.S174*|BUB1_ENST00000302759.6_Nonsense_Mutation_p.S174*	NM_001278616.1	NP_001265545.1	O43683	BUB1_HUMAN	BUB1 mitotic checkpoint serine/threonine kinase	174	BUB1 N-terminal.				apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			breast(3)|endometrium(8)|kidney(4)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|stomach(1)	45		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		ATTTGATTTTGATGTTATCAT	0.358000													4	116					0	0	0.009096	0	0
RXRA	6256	broad.mit.edu	37	9	137328351	137328351	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr9:137328351C>T	ENST00000540193.1	+	9	1912	c.989C>T	c.(988-990)tCc>tTc	p.S330F	RXRA_ENST00000481739.1_Missense_Mutation_p.S427F|RXRA_ENST00000356384.4_3'UTR			P19793	RXRA_HUMAN	retinoid X receptor, alpha	427	Ligand-binding.				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	GCTCTGCGCTCCATCGGGCTC	0.607000													5	86					0	0	0.021553	0	0
SLC4A10	57282	broad.mit.edu	37	2	162751249	162751249	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:162751249G>C	ENST00000375514.5	+	11	1485	c.1198G>C	c.(1198-1200)Gag>Cag	p.E400Q	SLC4A10_ENST00000415876.2_Missense_Mutation_p.E389Q|SLC4A10_ENST00000421911.1_Missense_Mutation_p.E419Q|SLC4A10_ENST00000493021.1_3'UTR|SLC4A10_ENST00000446997.1_Missense_Mutation_p.E419Q|SLC4A10_ENST00000272716.5_Missense_Mutation_p.E389Q|SLC4A10_ENST00000535165.1_Missense_Mutation_p.M389I	NM_001178016.1	NP_001171487.1	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate transporter, member 10	419					bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(35)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						AGGAATTGATGAGTTTCTGGA	0.353000													8	94					0	0	0.006214	0	0
C8B	732	broad.mit.edu	37	1	57409489	57409489	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr1:57409489G>C	ENST00000543257.1	-	9	1524	c.958C>G	c.(958-960)Ctt>Gtt	p.L320V	C8B_ENST00000371237.4_Missense_Mutation_p.L372V|C8B_ENST00000535057.1_Missense_Mutation_p.L310V	NM_001278543.1	NP_001265472.1	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	372	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	52						ACGTTGTTAAGAGTATAATCT	0.443000													6	112					0	0	0.021553	0	0
DEPDC7	91614	broad.mit.edu	37	11	33054490	33054490	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr11:33054490G>A	ENST00000311388.3	+	8	1668	c.1292G>A	c.(1291-1293)gGa>gAa	p.G431E	DEPDC7_ENST00000241051.3_Missense_Mutation_p.G440E	NM_139160.2	NP_631899.2	Q96QD5	DEPD7_HUMAN	DEP domain containing 7	440					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			endometrium(2)|large_intestine(4)|lung(8)|ovary(1)|skin(2)	17						ATACAGAACGGAAGAGATCCA	0.318000													17	119					0	0	0.008871	0	0
ESPL1	9700	broad.mit.edu	37	12	53662888	53662888	+	Silent	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr12:53662888G>A	ENST00000257934.4	+	3	253	c.162G>A	c.(160-162)ctG>ctA	p.L54L	ESPL1_ENST00000552462.1_Silent_p.L54L	NM_012291.4	NP_036423.4	Q14674	ESPL1_HUMAN	extra spindle pole bodies homolog 1 (S. cerevisiae)	54					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(10)|large_intestine(12)|lung(21)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(8)	70						ATGCCATCCTGAGGGCTTGCA	0.552000													6	91					0	0	0.029380	0	0
EPHB4	2050	broad.mit.edu	37	7	100410820	100410820	+	Silent	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr7:100410820G>A	ENST00000358173.3	-	11	2235	c.1767C>T	c.(1765-1767)gtC>gtT	p.V589V	EPHB4_ENST00000360620.3_Silent_p.V589V	NM_004444.4	NP_004435.3	P54760	EPHB4_HUMAN	EPH receptor B4	589					cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(7)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(3)	47	Lung NSC(181;0.041)|all_lung(186;0.0581)					GGTCGATGTAGACCTTAGTAC	0.507000													4	88					0	0	0.009096	0	0
LRRC66	339977	broad.mit.edu	37	4	52860928	52860928	+	Missense_Mutation	SNP	C	C	T	rs76998469		TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr4:52860928C>T	ENST00000343457.3	-	4	2266	c.2260G>A	c.(2260-2262)Gag>Aag	p.E754K		NM_001024611.1	NP_001019782.1	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	754						integral to membrane				central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(8)|lung(34)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	58						ACATTTTCCTCAAGACTGTCT	0.483000													7	120					0	0	0.038147	0	0
DGKQ	1609	broad.mit.edu	37	4	954890	954890	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr4:954890C>T	ENST00000273814.3	-	22	2747	c.2674G>A	c.(2674-2676)Gag>Aag	p.E892K		NM_001347.3	NP_001338.2	P52824	DGKQ_HUMAN	diacylglycerol kinase, theta 110kDa	892					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|platelet activation|protein kinase C signaling cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to ATP|thrombin receptor signaling pathway	cytoskeleton|cytosol|nuclear speck|plasma membrane	activating transcription factor binding|ATP binding|diacylglycerol kinase activity|kinase binding|metal ion binding|phospholipase binding			breast(1)|endometrium(2)|kidney(2)|lung(2)|prostate(2)	9			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			ACCCAGGGCTCCCCGTCCACC	0.692000													4	28					0	0	0.009096	0	0
CMAS	55907	broad.mit.edu	37	12	22208488	22208488	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr12:22208488C>G	ENST00000229329.2	+	3	633	c.503C>G	c.(502-504)tCt>tGt	p.S168C		NM_018686.4	NP_061156.1	Q8NFW8	NEUA_HUMAN	cytidine monophosphate N-acetylneuraminic acid synthetase	168					lipopolysaccharide biosynthetic process	nucleus	N-acylneuraminate cytidylyltransferase activity			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	24						GGATATGATTCTGTTTTCTCT	0.353000													7	114					0	0	0.029380	0	0
DEPDC7	91614	broad.mit.edu	37	11	33053080	33053080	+	Silent	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr11:33053080G>A	ENST00000311388.3	+	5	1288	c.912G>A	c.(910-912)agG>agA	p.R304R	DEPDC7_ENST00000241051.3_Silent_p.R313R	NM_139160.2	NP_631899.2	Q96QD5	DEPD7_HUMAN	DEP domain containing 7	313					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			endometrium(2)|large_intestine(4)|lung(8)|ovary(1)|skin(2)	17						ACAGTAGTAGGGAACCTCTGT	0.393000													7	129					0	0	0.008291	0	0
CHUK	1147	broad.mit.edu	37	10	101978578	101978578	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr10:101978578C>T	ENST00000370397.7	-	8	780	c.694G>A	c.(694-696)Gag>Aag	p.E232K		NM_001278.3	NP_001269.3	O15111	IKKA_HUMAN	conserved helix-loop-helix ubiquitous kinase	232	Protein kinase.				I-kappaB phosphorylation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|nucleus	ATP binding|identical protein binding|IkappaB kinase activity			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(9)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(1)	27		Colorectal(252;0.117)		Epithelial(162;2.05e-10)|all cancers(201;1.91e-08)		TTAATCTTCTCATGCCTATAA	0.328000													8	93					0	0	0.038147	0	0
PBX1	5087	broad.mit.edu	37	1	164761814	164761814	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr1:164761814G>A	ENST00000420696.2	+	3	537	c.349G>A	c.(349-351)Gtg>Atg	p.V117M	PBX1_ENST00000560641.1_Missense_Mutation_p.V12M|PBX1_ENST00000540236.1_Missense_Mutation_p.V117M|PBX1_ENST00000401534.1_Missense_Mutation_p.V117M|PBX1_ENST00000540246.1_Missense_Mutation_p.V12M|PBX1_ENST00000367897.1_Missense_Mutation_p.V117M|PBX1_ENST00000559240.1_Missense_Mutation_p.V117M	NM_001204961.1|NM_001204963.1|NM_002585.3	NP_001191890.1|NP_001191892.1|NP_002576.1	P40424	PBX1_HUMAN	pre-B-cell leukemia homeobox 1	117					negative regulation of sequence-specific DNA binding transcription factor activity|sex differentiation|steroid biosynthetic process	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription factor binding		EWSR1/PBX1(3)	large_intestine(1)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	4						AGCGGAAGGCGTGGCGGGGCC	0.622000			T	"""TCF3, EWSR1"""	"""pre B-ALL, myoepithelioma"""								3	18					0	0	0.004672	0	0
SPHKAP	80309	broad.mit.edu	37	2	228883236	228883236	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:228883236G>T	ENST00000392056.3	-	7	2380	c.2334C>A	c.(2332-2334)caC>caA	p.H778Q	SPHKAP_ENST00000344657.5_Missense_Mutation_p.H778Q	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	778						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GACTCGTGTTGTGTGAATTGC	0.512000													30	451					1.80694e-10	2.04857e-10	0.041601	1	0
EXPH5	23086	broad.mit.edu	37	11	108382830	108382830	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr11:108382830C>A	ENST00000265843.4	-	6	3514	c.3404G>T	c.(3403-3405)gGa>gTa	p.G1135V	EXPH5_ENST00000525344.1_Missense_Mutation_p.G1128V|EXPH5_ENST00000428840.1_Missense_Mutation_p.G1059V|EXPH5_ENST00000443411.1_Missense_Mutation_p.G947V	NM_015065.2	NP_055880	Q149M6	Q149M6_HUMAN	exophilin 5	1135					intracellular protein transport		Rab GTPase binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		TCCTTCTCTTCCAGTTGAGGC	0.483000													8	129					7.48243e-07	8.29019e-07	0.006214	1	0
DCLK2	166614	broad.mit.edu	37	4	151023764	151023764	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr4:151023764G>A	ENST00000296550.7	+	2	1310	c.556G>A	c.(556-558)Gaa>Aaa	p.E186K	DCLK2_ENST00000302176.8_Missense_Mutation_p.E186K|DCLK2_ENST00000506325.1_Missense_Mutation_p.E186K	NM_001040260.3	NP_001035350.2	Q8N568	DCLK2_HUMAN	doublecortin-like kinase 2	186					intracellular signal transduction	cytoplasm|cytoskeleton	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(7)|ovary(3)|pancreas(1)|prostate(1)|skin(1)	26	all_hematologic(180;0.151)					TGTGAAAAGTGAAGTAAAAGA	0.428000													10	53					0	0	0.008291	0	0
SLC25A6	293	broad.mit.edu	37	X	1508489	1508489	+	Silent	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chrX:1508489G>A	ENST00000381401.5	-	2	957	c.243C>T	c.(241-243)taC>taT	p.Y81Y	SLC25A6_ENST00000475167.1_5'UTR	NM_001636.3	NP_001627.2	P12236	ADT3_HUMAN	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6	81					active induction of host immune response by virus|apoptosis|energy reserve metabolic process|regulation of insulin secretion|viral infectious cycle	integral to membrane|mitochondrial inner membrane presequence translocase complex	ATP:ADP antiporter activity|protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(8)|upper_aerodigestive_tract(1)	11		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Clodronate(DB00720)	GAGTGGGGAAGTAGCGAATGA	0.567000													11	189					0	0	0.010729	0	0
VWA7	80737	broad.mit.edu	37	6	31735227	31735227	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr6:31735227G>C	ENST00000375686.3	-	12	1938	c.1701C>G	c.(1699-1701)ttC>ttG	p.F567L	VWA7_ENST00000447450.1_Missense_Mutation_p.F567L|VWA7_ENST00000375688.4_Missense_Mutation_p.F567L|VWA7_ENST00000467576.1_5'UTR	NM_025258.2	NP_079534.2	Q9Y334	G7C_HUMAN	von Willebrand factor A domain containing 7	567						extracellular region											TCACCATCCAGAACTGCCCAA	0.602000													6	108					0	0	0.004482	0	0
PLEKHM3	389072	broad.mit.edu	37	2	208841675	208841675	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:208841675C>A	ENST00000457206.1	-	3	1673	c.1246G>T	c.(1246-1248)Gac>Tac	p.D416Y	PLEKHM3_ENST00000389247.4_Missense_Mutation_p.D416Y|PLEKHM3_ENST00000427836.2_Missense_Mutation_p.D416Y			Q6ZWE6	PKHM3_HUMAN	pleckstrin homology domain containing, family M, member 3	416	PH 2.				intracellular signal transduction		metal ion binding			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						TCCAGGTTGTCCATCTGGACA	0.552000													6	58					0.0293803	0.0313069	0.029380	1	0
MUC13	56667	broad.mit.edu	37	3	124646827	124646827	+	Silent	SNP	T	T	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr3:124646827T>C	ENST00000311075.3	-	2	101	c.63A>G	c.(61-63)caA>caG	p.Q21Q	MUC13_ENST00000497378.1_5'UTR	NM_033049.3	NP_149038	Q9H3R2	MUC13_HUMAN	mucin 13, cell surface associated	21						extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(5)|prostate(1)|skin(1)|stomach(1)	18						CTGAGTTGCCTTGGTTGGTGG	0.418000													3	140					0	0	0.004672	0	0
ATRX	546	broad.mit.edu	37	X	76939952	76939952	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chrX:76939952A>T	ENST00000373344.5	-	9	1010	c.796T>A	c.(796-798)Tac>Aac	p.Y266N	ATRX_ENST00000480283.1_5'UTR|ATRX_ENST00000395603.3_Missense_Mutation_p.Y228N	NM_000489.3	NP_000480.3	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	266	ADD.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.?(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	TGACAAATGTAGCAATACCAT	0.388000			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						7	448					0	0	0.029380	0	0
TBC1D1	23216	broad.mit.edu	37	4	37903928	37903928	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr4:37903928C>T	ENST00000261439.4	+	2	567	c.212C>T	c.(211-213)tCt>tTt	p.S71F	TBC1D1_ENST00000508802.1_Missense_Mutation_p.S71F|TBC1D1_ENST00000402522.1_Missense_Mutation_p.S71F	NM_001253914.1|NM_001253915.1|NM_015173.3	NP_001240843.1|NP_001240844.1|NP_055988.2	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	71						nucleus	Rab GTPase activator activity			NS(1)|breast(3)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	36						GTTTCACCCTCTGGACTGAGA	0.547000													6	168					0	0	0.029380	0	0
ZNF502	91392	broad.mit.edu	37	3	44763393	44763393	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr3:44763393C>G	ENST00000296091.4	+	4	1340	c.1084C>G	c.(1084-1086)Cag>Gag	p.Q362E	ZNF502_ENST00000436624.2_Missense_Mutation_p.Q362E|ZNF502_ENST00000449836.1_Missense_Mutation_p.Q362E	NM_001134440.1|NM_001282880.1|NM_033210.4	NP_001127912.1|NP_001269809.1|NP_149987.2	Q8TBZ5	ZN502_HUMAN	zinc finger protein 502	362					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(4)|large_intestine(8)|lung(4)|prostate(1)|urinary_tract(1)	19				BRCA - Breast invasive adenocarcinoma(193;0.00855)|KIRC - Kidney renal clear cell carcinoma(197;0.0471)|Kidney(197;0.0589)		AGCCTTTTGTCAGAGCCCATC	0.408000													7	72					0	0	0.029380	0	0
DEPDC7	91614	broad.mit.edu	37	11	33054924	33054924	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr11:33054924G>A	ENST00000311388.3	+	9	1808	c.1432G>A	c.(1432-1434)Gcc>Acc	p.A478T	DEPDC7_ENST00000241051.3_Missense_Mutation_p.A487T	NM_139160.2	NP_631899.2	Q96QD5	DEPD7_HUMAN	DEP domain containing 7	487					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			endometrium(2)|large_intestine(4)|lung(8)|ovary(1)|skin(2)	17						AAAACTTTCTGCCAAAGAGAA	0.333000													6	140					0	0	0.029380	0	0
PPM1E	22843	broad.mit.edu	37	17	57058003	57058003	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr17:57058003C>A	ENST00000308249.2	+	7	2008	c.1879C>A	c.(1879-1881)Ccc>Acc	p.P627T		NM_014906.4	NP_055721.3	Q8WY54	PPM1E_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1E	636					protein dephosphorylation	cytoplasm|nucleolus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			biliary_tract(1)|breast(3)|endometrium(4)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(2)	33	Medulloblastoma(34;0.127)|all_neural(34;0.237)		BRCA - Breast invasive adenocarcinoma(1;5.76e-11)			TGGAGAGTTTCCCACTGCTTT	0.428000													9	260					0.000274275	0.000302168	0.004482	1	0
KIAA1109	84162	broad.mit.edu	37	4	123166210	123166210	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr4:123166210G>A	ENST00000264501.4	+	32	5325	c.4952G>A	c.(4951-4953)cGa>cAa	p.R1651Q	KIAA1109_ENST00000388738.3_Missense_Mutation_p.R1651Q|KIAA1109_ENST00000455637.1_Missense_Mutation_p.R1651Q			Q2LD37	K1109_HUMAN	KIAA1109	1651					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						GCTAGTACCCGACATCCAGCT	0.343000													8	192					0	0	0.038147	0	0
DNM1P47	100216544	broad.mit.edu	37	15	102304859	102304859	+	RNA	SNP	G	G	A	rs150791489	by1000genomes	TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr15:102304859G>A	ENST00000561463.1	+	0	12905																											CGGAGCTGCTGTCCAACCTGT	0.577000													3	12					0	0	0.004672	0	0
MAP2	4133	broad.mit.edu	37	2	210560016	210560016	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:210560016C>T	ENST00000360351.4	+	7	3628	c.3122C>T	c.(3121-3123)gCt>gTt	p.A1041V	MAP2_ENST00000199940.6_Intron|MAP2_ENST00000361559.4_Intron|MAP2_ENST00000392194.1_Intron|MAP2_ENST00000447185.1_Missense_Mutation_p.A1037V	NM_002374.3	NP_002365.3	P11137	MAP2_HUMAN	microtubule-associated protein 2	1041					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(36)|liver(2)|lung(42)|ovary(11)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	124		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	CTGGATTTTGCTGTCCAGGGT	0.443000													5	101					0	0	0.014758	0	0
PFAS	5198	broad.mit.edu	37	17	8168266	8168266	+	Silent	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr17:8168266G>A	ENST00000314666.6	+	18	2236	c.2103G>A	c.(2101-2103)ctG>ctA	p.L701L	PFAS_ENST00000545834.1_Silent_p.L277L	NM_012393.2	NP_036525.1	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase	701					'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(2)|lung(9)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	35					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	TGGGGCCCCTGCAAACTCCTC	0.632000													3	8					0	0	0.004672	0	0
FASTKD1	79675	broad.mit.edu	37	2	170417266	170417266	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:170417266G>T	ENST00000453153.2	-	5	948	c.602C>A	c.(601-603)tCt>tAt	p.S201Y	FASTKD1_ENST00000453929.2_Missense_Mutation_p.S201Y	NM_024622.3	NP_078898.3	Q53R41	FAKD1_HUMAN	FAST kinase domains 1	201					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(5)|large_intestine(10)|lung(9)|ovary(4)|prostate(3)	37						TATTAAAGAAGATATGTTGAC	0.294000													4	48					0.000602214	0.000656044	0.014758	1	0
IQCG	84223	broad.mit.edu	37	3	197665561	197665561	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr3:197665561C>T	ENST00000265239.6	-	5	797	c.373G>A	c.(373-375)Gag>Aag	p.E125K	IQCG_ENST00000455191.1_Missense_Mutation_p.E125K|IQCG_ENST00000453254.1_Missense_Mutation_p.E125K|IQCG_ENST00000480302.1_5'UTR	NM_032263.3	NP_115639.1	Q9H095	IQCG_HUMAN	IQ motif containing G	125										autonomic_ganglia(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(3)|lung(10)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;7.19e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.149)		GGTCCTTCCTCAGTTATTAAC	0.413000													33	497					0	0	0.019004	0	0
A2ML1	144568	broad.mit.edu	37	12	9020914	9020914	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr12:9020914C>A	ENST00000299698.7	+	31	4202	c.4022C>A	c.(4021-4023)cCg>cAg	p.P1341Q	A2ML1_ENST00000539547.1_Missense_Mutation_p.P850Q	NM_001282424.1|NM_144670.4	NP_001269353.1|NP_653271	B3KVV6	B3KVV6_HUMAN	alpha-2-macroglobulin-like 1	1185						extracellular space	endopeptidase inhibitor activity	p.P1341L(1)		NS(2)|breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(2)|lung(36)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	80						TGTGAGCAACCGACTTCACCT	0.488000													17	254					1.15088e-07	1.28978e-07	0.028581	1	0
SUN2	25777	broad.mit.edu	37	22	39141785	39141785	+	Silent	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr22:39141785C>T	ENST00000405510.1	-	9	1075	c.717G>A	c.(715-717)caG>caA	p.Q239Q	SUN2_ENST00000406622.1_Silent_p.Q239Q|SUN2_ENST00000411587.2_Silent_p.Q228Q|SUN2_ENST00000216064.4_Silent_p.Q239Q|RP3-508I15.14_ENST00000416406.1_RNA|SUN2_ENST00000405018.1_Silent_p.Q260Q	NM_001199580.1	NP_001186509.1	Q9UH99	SUN2_HUMAN	Sad1 and UNC84 domain containing 2	239					centrosome localization|cytoskeletal anchoring at nuclear membrane|mitotic spindle organization|nuclear envelope organization|nuclear matrix anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	endosome membrane|integral to membrane|nuclear inner membrane|SUN-KASH complex	lamin binding|microtubule binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|skin(2)|stomach(1)	15						GGTGGAATGTCTGCAGCCCAT	0.617000													4	38					0	0	0.009096	0	0
CEP152	22995	broad.mit.edu	37	15	49076285	49076285	+	Silent	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr15:49076285C>T	ENST00000380950.2	-	10	1393	c.1206G>A	c.(1204-1206)gtG>gtA	p.V402V	CEP152_ENST00000399334.3_Silent_p.V402V|RP11-485O10.2_ENST00000558304.1_RNA|CEP152_ENST00000325747.5_Silent_p.V309V	NM_001194998.1|NM_014985.3	NP_001181927.1|NP_055800.2	O94986	CE152_HUMAN	centrosomal protein 152kDa	402					centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			breast(3)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(16)|lung(30)|ovary(1)|prostate(2)|skin(2)	63		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)		CCAGTTGTTTCACGTGATCTT	0.333000													5	66					0	0	0.021553	0	0
DNAJC13	23317	broad.mit.edu	37	3	132166277	132166277	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr3:132166277C>T	ENST00000260818.6	+	4	505	c.257C>T	c.(256-258)tCt>tTt	p.S86F	DNAJC13_ENST00000486798.1_3'UTR	NM_015268.3	NP_056083.3	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	86							heat shock protein binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|urinary_tract(1)	34						TTAAAATTTTCTACAGAGCAC	0.353000													5	83					0	0	0.021553	0	0
ZKSCAN3	80317	broad.mit.edu	37	6	28333833	28333833	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr6:28333833G>A	ENST00000377255.3	+	7	1685	c.1388G>A	c.(1387-1389)tGg>tAg	p.W463*	ZKSCAN3_ENST00000341464.5_Nonsense_Mutation_p.W315*|ZKSCAN3_ENST00000252211.2_Nonsense_Mutation_p.W463*	NM_001242894.1	NP_001229823.1	Q9BRR0	ZKSC3_HUMAN	zinc finger with KRAB and SCAN domains 3	463				QGEAWKSRMESQLENVETPMS -> TGRGWKVGWKASWKML KLPCP (in Ref. 5; AAB16813).	positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	chromatin binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			kidney(4)|large_intestine(3)|lung(8)|pancreas(1)|skin(2)|stomach(2)|urinary_tract(1)	21						GGAGAGGCCTGGAAAAGTAGG	0.433000													5	60					0	0	0.021553	0	0
DBF4	10926	broad.mit.edu	37	7	87516657	87516657	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr7:87516657C>T	ENST00000265728.1	+	5	968	c.464C>T	c.(463-465)tCa>tTa	p.S155L		NM_006716.3	NP_006707.1	Q9UBU7	DBF4A_HUMAN	DBF4 homolog (S. cerevisiae)	155	BRCT 2.				cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	enzyme activator activity|nucleic acid binding|protein binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(13)|ovary(1)|skin(3)	28	Esophageal squamous(14;0.00202)	Breast(660;0.0334)				TTTATTCCTTCAAATAGTATA	0.229000													4	36					0	0	0.009096	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54894397	54894397	+	Silent	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr12:54894397C>T	ENST00000293373.6	+	3	373	c.294C>T	c.(292-294)gtC>gtT	p.V98V	NCKAP1L_ENST00000545638.2_Silent_p.V48V	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	98					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						TTGTGGATGTCATGGAATTTC	0.398000													13	181					0	0	0.016723	0	0
DDX53	168400	broad.mit.edu	37	X	23019978	23019978	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chrX:23019978G>A	ENST00000327968.5	+	1	1892	c.1804G>A	c.(1804-1806)Gag>Aag	p.E602K	RP11-40F8.2_ENST00000455399.1_lincRNA	NM_182699.3	NP_874358.2	Q86TM3	DDX53_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 53	602						nucleus	ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(5)|kidney(4)|large_intestine(3)|lung(15)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	35						AGTAATGGCTGAGCAATACAA	0.383000													4	120					0	0	0.009096	0	0
LRRC46	90506	broad.mit.edu	37	17	45913412	45913412	+	Silent	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr17:45913412G>A	ENST00000269025.4	+	6	759	c.396G>A	c.(394-396)caG>caA	p.Q132Q		NM_033413.3	NP_219481.1	Q96FV0	LRC46_HUMAN	leucine rich repeat containing 46	132										endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)	9						AGTTCCCCCAGAGCCTTCTCA	0.522000													7	58					0	0	0.029380	0	0
SLC41A3	54946	broad.mit.edu	37	3	125726027	125726027	+	Silent	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr3:125726027C>T	ENST00000383598.2	-	10	1503	c.1218G>A	c.(1216-1218)ctG>ctA	p.L406L	SLC41A3_ENST00000315891.6_Silent_p.L432L|SLC41A3_ENST00000346785.5_Silent_p.L396L|SLC41A3_ENST00000360370.4_Silent_p.L432L|SLC41A3_ENST00000508835.1_Silent_p.L315L	NM_001008487.1	NP_001008487.1	Q96GZ6	S41A3_HUMAN	solute carrier family 41, member 3	432						integral to membrane|plasma membrane	cation transmembrane transporter activity			breast(1)|endometrium(4)|large_intestine(6)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	18				GBM - Glioblastoma multiforme(114;0.167)		GGTGCCAAGTCAGCCGAACCA	0.547000													4	46					0	0	0.014758	0	0
VWA7	80737	broad.mit.edu	37	6	31734536	31734536	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr6:31734536G>C	ENST00000375686.3	-	14	2125	c.1888C>G	c.(1888-1890)Cag>Gag	p.Q630E	VWA7_ENST00000447450.1_Missense_Mutation_p.Q630E|VWA7_ENST00000375688.4_Missense_Mutation_p.Q630E|VWA7_ENST00000467576.1_5'UTR	NM_025258.2	NP_079534.2	Q9Y334	G7C_HUMAN	von Willebrand factor A domain containing 7	630						extracellular region											AGCTGGGTCTGAAGACCTGGG	0.557000													4	52					0	0	0.009096	0	0
ARHGEF4	50649	broad.mit.edu	37	2	131799455	131799455	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:131799455A>C	ENST00000392953.3	+	10	1924	c.1405A>C	c.(1405-1407)Aag>Cag	p.K469Q	ARHGEF4_ENST00000428230.2_Intron|ARHGEF4_ENST00000409303.1_Missense_Mutation_p.K409Q|ARHGEF4_ENST00000525839.1_Missense_Mutation_p.K469Q|ARHGEF4_ENST00000326016.5_Missense_Mutation_p.K469Q|ARHGEF4_ENST00000355771.3_Missense_Mutation_p.K398Q	NM_032995.1	NP_127462.1	Q9NR80	ARHG4_HUMAN	Rho guanine nucleotide exchange factor (GEF) 4	469					apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|lamellipodium assembly|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|ruffle membrane	protein domain specific binding|Rac guanyl-nucleotide exchange factor activity			NS(1)|breast(4)|cervix(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(3)|pancreas(1)|prostate(1)|skin(4)	29		Prostate(154;0.055)		BRCA - Breast invasive adenocarcinoma(221;0.097)		CAACGAGCGGAAGCGGAGACT	0.562000													3	58					0	0	0.004672	0	0
CCDC142	84865	broad.mit.edu	37	2	74709847	74709847	+	Missense_Mutation	SNP	G	G	A	rs143866681	byFrequency	TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:74709847G>A	ENST00000393965.3	-	1	514	c.118C>T	c.(118-120)Cgc>Tgc	p.R40C	CCDC142_ENST00000290418.4_Missense_Mutation_p.R40C|CCDC142_ENST00000471713.1_Intron	NM_032779.3	NP_116168.3	Q17RM4	CC142_HUMAN	coiled-coil domain containing 142	40										central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|skin(2)|urinary_tract(2)	16						ACCTCCCAGCGAAGACCGCCC	0.682000													8	62					0	0	0.004482	0	0
DNAH10	196385	broad.mit.edu	37	12	124362399	124362399	+	Silent	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr12:124362399C>T	ENST00000409039.3	+	47	7987	c.7962C>T	c.(7960-7962)ttC>ttT	p.F2654F		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2654	AAA 3 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		ATTACATCTTCAACCTTCGAG	0.443000													18	259					0	0	0.043863	0	0
KIAA0754	643314	broad.mit.edu	37	1	39878410	39878410	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr1:39878410G>C	ENST00000530275.1	+	1	2260	c.2065G>C	c.(2065-2067)Gag>Cag	p.E689Q	MACF1_ENST00000539005.1_Intron|MACF1_ENST00000289893.4_Intron|MACF1_ENST00000317713.7_Intron|MACF1_ENST00000372915.3_Intron|MACF1_ENST00000545844.1_Intron|MACF1_ENST00000564288.1_Intron|MACF1_ENST00000361689.2_Intron|MACF1_ENST00000567887.1_Intron	NM_015038.1	NP_055853.1	O94854	K0754_HUMAN	KIAA0754	689										central_nervous_system(1)|large_intestine(6)|skin(1)	8	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			ACCAGTTTTAGAGGAATGGAT	0.493000													3	24					0	0	0.009096	0	0
NTSR1	4923	broad.mit.edu	37	20	61391508	61391508	+	Silent	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr20:61391508C>G	ENST00000370501.3	+	4	1517	c.1146C>G	c.(1144-1146)ctC>ctG	p.L382L	NTSR1_ENST00000482259.1_3'UTR	NM_002531.2	NP_002522.2	P30989	NTR1_HUMAN	neurotensin receptor 1 (high affinity)	382						endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	neurotensin receptor activity, G-protein coupled			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(16)|prostate(1)|skin(3)	27	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;3.63e-06)			TGGCCTGCCTCTGCCCGGTGT	0.627000													3	57					0	0	0.038147	0	0
KCNK2	3776	broad.mit.edu	37	1	215256745	215256745	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr1:215256745C>T	ENST00000444842.2	+	1	167	c.17C>T	c.(16-18)tCg>tTg	p.S6L	KCNK2_ENST00000391894.2_Intron|KCNK2_ENST00000391895.2_Intron	NM_001017425.2|NM_014217.3	NP_001017425.2|NP_055032.1	O95069	KCNK2_HUMAN	potassium channel, subfamily K, member 2	6							outward rectifier potassium channel activity	p.S6W(2)		endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|upper_aerodigestive_tract(1)	30				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)	CCCAGCGCCTCGCGGGAGAGA	0.547000													9	79					0	0	0.008291	0	0
ZNF358	140467	broad.mit.edu	37	19	7584139	7584139	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr19:7584139C>T	ENST00000599312.1	+	2	109	c.109C>T	c.(109-111)Cag>Tag	p.Q37*	ZNF358_ENST00000597229.1_Missense_Mutation_p.S4L|ZNF358_ENST00000394341.2_Missense_Mutation_p.S4L																							ATGCGGCGCTCAGTCCTGGTC	0.597000													6	81					0	0	0.021553	0	0
ATAD1	84896	broad.mit.edu	37	10	89516664	89516664	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr10:89516664C>G	ENST00000308448.7	-	9	1225	c.847G>C	c.(847-849)Gac>Cac	p.D283H	ATAD1_ENST00000328142.3_Missense_Mutation_p.D283H|ATAD1_ENST00000400215.3_Missense_Mutation_p.D195H	NM_032810.2	NP_116199.2	Q8NBU5	ATAD1_HUMAN	ATPase family, AAA domain containing 1	283						peroxisome	ATP binding|nucleoside-triphosphatase activity			kidney(1)|large_intestine(4)|lung(4)|ovary(1)	10		all_cancers(4;6.78e-12)|Prostate(4;3.56e-12)|all_epithelial(4;5.58e-09)|Melanoma(5;0.0273)|Breast(4;0.0424)|all_hematologic(4;0.0846)|Colorectal(252;0.207)|Glioma(4;0.217)|all_neural(4;0.224)		UCEC - Uterine corpus endometrioid carcinoma (6;0.00131)|GBM - Glioblastoma multiforme(1;1.1e-32)|Lung(2;1.4e-05)|LUSC - Lung squamous cell carcinoma(2;2.69e-05)|Colorectal(12;7.09e-05)|COAD - Colon adenocarcinoma(12;0.000261)|STAD - Stomach adenocarcinoma(243;0.235)		TCTAGCAGGTCTACATGCCTA	0.353000													6	99					0	0	0.021553	0	0
DEPDC7	91614	broad.mit.edu	37	11	33054239	33054239	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr11:33054239G>C	ENST00000311388.3	+	7	1512	c.1136G>C	c.(1135-1137)aGg>aCg	p.R379T	DEPDC7_ENST00000241051.3_Missense_Mutation_p.R388T	NM_139160.2	NP_631899.2	Q96QD5	DEPD7_HUMAN	DEP domain containing 7	388					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			endometrium(2)|large_intestine(4)|lung(8)|ovary(1)|skin(2)	17						GTTGTGAAAAGGATATTCTCA	0.259000													16	106					0	0	0.024245	0	0
METTL8	79828	broad.mit.edu	37	2	172195788	172195788	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:172195788G>A	ENST00000375258.4	-	4	727	c.512C>T	c.(511-513)tCt>tTt	p.S171F		NM_024770.3	NP_079046.2	B3KW44	B3KW44_HUMAN	methyltransferase like 8								methyltransferase activity			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|ovary(1)	11						GGAAAAATCAGATTCTGTTTT	0.383000													14	269					0	0	0.020292	0	0
TNK2	10188	broad.mit.edu	37	3	195593873	195593873	+	Silent	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr3:195593873G>A	ENST00000333602.6	-	14	3614	c.2997C>T	c.(2995-2997)ttC>ttT	p.F999F	TNK2_ENST00000428187.1_Silent_p.F1001F|TNK2_ENST00000381916.2_Silent_p.F1047F|TNK2_ENST00000392400.1_Silent_p.F999F	NM_005781.4	NP_005772.3	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2	999				Missing (in Ref. 4; AAH08884).	positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(11)|ovary(3)|prostate(4)|skin(2)|stomach(1)|urinary_tract(1)	29	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	GACCCAGCCCGAAGAGCTGCT	0.697000													3	21					0	0	0.009096	0	0
FRAS1	80144	broad.mit.edu	37	4	79294005	79294005	+	Silent	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr4:79294005C>G	ENST00000264895.6	+	24	3443	c.3003C>G	c.(3001-3003)ctC>ctG	p.L1001L	FRAS1_ENST00000325942.6_Silent_p.L1001L	NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	1001					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						ACTCGGGCCTCTGCAAGAGTA	0.537000													8	86					0	0	0.006214	0	0
CORO2B	10391	broad.mit.edu	37	15	69018260	69018260	+	Missense_Mutation	SNP	C	C	T	rs146678597		TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr15:69018260C>T	ENST00000543950.1	+	12	1729	c.1375C>T	c.(1375-1377)Cgg>Tgg	p.R459W	CORO2B_ENST00000261861.5_Missense_Mutation_p.R459W|CORO2B_ENST00000540068.1_Missense_Mutation_p.R459W|CORO2B_ENST00000566799.1_Missense_Mutation_p.R464W	NM_001190457.1	NP_001177386.1	Q9UQ03	COR2B_HUMAN	coronin, actin binding protein, 2B	464					actin cytoskeleton organization	actin cytoskeleton|cytoplasm|membrane	actin filament binding			kidney(3)|large_intestine(13)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36						CATCCGCATTCGGCAGCTCCA	0.557000													4	52					0	0	0.009096	0	0
OR4K1	79544	broad.mit.edu	37	14	20404396	20404396	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr14:20404396G>A	ENST00000285600.4	+	1	630	c.571G>A	c.(571-573)Gat>Aat	p.D191N		NM_001004063.2	NP_001004063.2	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K, member 1	191					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(24)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		GGCTTGCATGGATACATATGA	0.443000													5	327					0	0	0.014758	0	0
LRP1B	53353	broad.mit.edu	37	2	141641540	141641540	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:141641540C>T	ENST00000389484.3	-	25	4986	c.4015G>A	c.(4015-4017)Ggc>Agc	p.G1339S		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1339					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ACTGTCAGGCCTTCTGGAGTA	0.468000										TSP Lung(27;0.18)			16	131					0	0	0.024245	0	0
C12orf66	144577	broad.mit.edu	37	12	64587993	64587993	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr12:64587993C>T	ENST00000311915.8	-	3	994	c.967G>A	c.(967-969)Gag>Aag	p.E323K	C12orf66_ENST00000544871.1_Missense_Mutation_p.E270K|C12orf66_ENST00000398055.3_Missense_Mutation_p.E323K			Q96MD2	CL066_HUMAN	chromosome 12 open reading frame 66	323										central_nervous_system(1)|large_intestine(1)|lung(2)|ovary(1)	5						TGAAAACTCTCAGAACCTCTG	0.473000													12	174					0	0	0.016723	0	0
TAS2R9	50835	broad.mit.edu	37	12	10962188	10962188	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr12:10962188C>G	ENST00000240691.2	-	1	579	c.487G>C	c.(487-489)Gaa>Caa	p.E163Q		NM_023917.2	NP_076406.1	Q9NYW1	TA2R9_HUMAN	taste receptor, type 2, member 9	163					sensory perception of taste	integral to membrane	taste receptor activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						GTAATGTTTTCTTCATGACTG	0.378000													12	107					0	0	0.016723	0	0
NAT10	55226	broad.mit.edu	37	11	34139781	34139781	+	Silent	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr11:34139781C>G	ENST00000257829.3	+	7	818	c.612C>G	c.(610-612)ctC>ctG	p.L204L	NAT10_ENST00000527971.1_Silent_p.L204L|NAT10_ENST00000531159.2_Silent_p.L132L	NM_024662.2	NP_078938	Q9H0A0	NAT10_HUMAN	N-acetyltransferase 10 (GCN5-related)	204						nucleolus	ATP binding|N-acetyltransferase activity|protein binding			endometrium(4)|large_intestine(8)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	23		Acute lymphoblastic leukemia(5;0.0119)|all_hematologic(20;0.0231)				ATGACCAGCTCAACATCCTGC	0.557000													10	60					0	0	0.016723	0	0
NUDT14	256281	broad.mit.edu	37	14	105639498	105639498	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr14:105639498C>T	ENST00000392568.2	-	5	622	c.529G>A	c.(529-531)Gag>Aag	p.E177K	RP11-44N21.4_ENST00000548203.1_RNA|NUDT14_ENST00000550912.1_5'UTR	NM_177533.4	NP_803877.2	O95848	NUD14_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 14	177	Nudix hydrolase.					cytoplasm	metal ion binding|protein binding|UDP-sugar diphosphatase activity	p.E177K(1)		cervix(2)|endometrium(1)|lung(3)|ovary(1)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	14		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		TCAATGAGCTCACCCTCCTCC	0.622000										HNSCC(42;0.11)			4	34					0	0	0.009096	0	0
CDC14B	8555	broad.mit.edu	37	9	99301371	99301371	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr9:99301371C>T	ENST00000375241.1	-	7	1067	c.616G>A	c.(616-618)Gaa>Aaa	p.E206K	CDC14B_ENST00000375240.3_Missense_Mutation_p.E206K|CDC14B_ENST00000375236.1_Missense_Mutation_p.E206K|CDC14B_ENST00000375242.3_Missense_Mutation_p.E169K|CDC14B_ENST00000463569.1_Missense_Mutation_p.E206K|CDC14B_ENST00000265659.2_Missense_Mutation_p.E206K	NM_003671.3|NM_033331.2	NP_003662.1|NP_201588.1	O60729	CC14B_HUMAN	cell division cycle 14B	206	Linker.				activation of anaphase-promoting complex activity|DNA repair|G2/M transition DNA damage checkpoint	nucleolus|nucleoplasm	protein binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)	15		Acute lymphoblastic leukemia(62;0.0559)				TCATAGTGTTCATATTCATCA	0.343000													7	91					0	0	0.029380	0	0
ABCC10	89845	broad.mit.edu	37	6	43400436	43400436	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr6:43400436G>A	ENST00000244533.3	+	1	948	c.589G>A	c.(589-591)Gag>Aag	p.E197K	ABCC10_ENST00000443426.2_Intron|ABCC10_ENST00000372530.4_Missense_Mutation_p.E240K	NM_033450.2	NP_258261.2	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 10	240						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(8)|lung(21)|ovary(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			GGCCTGTGGAGAGCTCCGGCA	0.637000													5	56					0	0	0.021553	0	0
CCDC134	79879	broad.mit.edu	37	22	42209814	42209814	+	Silent	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr22:42209814C>T	ENST00000255784.5	+	6	656	c.552C>T	c.(550-552)atC>atT	p.I184I	CCDC134_ENST00000402061.3_Intron	NM_024821.2	NP_079097.1	Q9H6E4	CC134_HUMAN	coiled-coil domain containing 134	184						extracellular region				large_intestine(1)|lung(2)|ovary(2)|skin(1)	6						CATTTAAAATCGACCGCACAG	0.567000													4	86					0	0	0.014758	0	0
KARS	3735	broad.mit.edu	37	16	75669620	75669620	+	Silent	SNP	G	G	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr16:75669620G>T	ENST00000319410.5	-	7	958	c.837C>A	c.(835-837)atC>atA	p.I279I	KARS_ENST00000302445.3_Silent_p.I251I|KARS_ENST00000568378.1_Intron	NM_001130089.1	NP_001123561.1	Q15046	SYK_HUMAN	lysyl-tRNA synthetase	251					interspecies interaction between organisms|lysyl-tRNA aminoacylation|tRNA processing	cytosol|extracellular region|mitochondrial matrix|nucleus|plasma membrane|soluble fraction	ATP binding|lysine-tRNA ligase activity|metal ion binding|tRNA binding			kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	18					L-Lysine(DB00123)	TTATATATGTGATGATCTTAG	0.443000													9	81					7.48243e-07	8.29019e-07	0.006214	1	0
DOPEY1	23033	broad.mit.edu	37	6	83845382	83845382	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr6:83845382C>T	ENST00000349129.2	+	20	3175	c.2915C>T	c.(2914-2916)tCt>tTt	p.S972F	DOPEY1_ENST00000369739.3_Missense_Mutation_p.S963F|DOPEY1_ENST00000237163.5_Missense_Mutation_p.S953F	NM_015018.3	NP_055833.2	Q5JWR5	DOP1_HUMAN	dopey family member 1	972					protein transport					breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(16)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	67		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		CTCGATGGTTCTACTAGCTCT	0.393000													14	182					0	0	0.020292	0	0
FOXK1	221937	broad.mit.edu	37	7	4794948	4794948	+	Silent	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr7:4794948G>C	ENST00000328914.4	+	4	984	c.984G>C	c.(982-984)ctG>ctC	p.L328L	FOXK1_ENST00000446823.1_Silent_p.L165L	NM_001037165.1	NP_001032242.1	P85037	FOXK1_HUMAN	forkhead box K1	328					cell differentiation|embryo development|muscle organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(7)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	29		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;7.43e-15)		AGCTGACCCTGAGCGGGATCT	0.642000													6	54					0	0	0.029380	0	0
KIAA1324L	222223	broad.mit.edu	37	7	86556202	86556202	+	Missense_Mutation	SNP	T	T	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr7:86556202T>G	ENST00000450689.2	-	9	1305	c.1120A>C	c.(1120-1122)Aaa>Caa	p.K374Q	KIAA1324L_ENST00000416314.1_Missense_Mutation_p.K207Q|KIAA1324L_ENST00000297222.6_Missense_Mutation_p.K134Q|KIAA1324L_ENST00000444627.1_Missense_Mutation_p.K374Q	NM_001142749.2	NP_001136221.1	A8MWY0	K132L_HUMAN	KIAA1324-like	374						integral to membrane				breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(14)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	44	Esophageal squamous(14;0.0058)					CGGCAGATTTTGGGCTCTATC	0.378000													5	190					0	0	0.014758	0	0
LAMB3	3914	broad.mit.edu	37	1	209789846	209789846	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr1:209789846C>T	ENST00000391911.1	-	21	3741	c.3352G>A	c.(3352-3354)Gag>Aag	p.E1118K	LAMB3_ENST00000356082.4_Missense_Mutation_p.E1118K|LAMB3_ENST00000367030.3_Missense_Mutation_p.E1118K	NM_001017402.1	NP_001017402.1	Q13751	LAMB3_HUMAN	laminin, beta 3	1118	Domain I.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		TCCATGGTCTCCCCAAACAGC	0.552000													9	183					0	0	0.013537	0	0
VPS54	51542	broad.mit.edu	37	2	64208891	64208891	+	Silent	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:64208891G>A	ENST00000409558.4	-	3	385	c.231C>T	c.(229-231)ttC>ttT	p.F77F	VPS54_ENST00000272322.4_Silent_p.F89F	NM_001005739.1|NM_016516.2	NP_001005739.1|NP_057600.2	Q9P1Q0	VPS54_HUMAN	vacuolar protein sorting 54 homolog (S. cerevisiae)						protein transport|retrograde transport, endosome to Golgi					endometrium(3)|kidney(4)|large_intestine(8)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	27						TTTTTGTGAAGAAGTCAGATT	0.388000													22	269					0	0	0.012319	0	0
OR52I2	143502	broad.mit.edu	37	11	4608745	4608745	+	Missense_Mutation	SNP	C	C	T	rs137965376	byFrequency	TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr11:4608745C>T	ENST00000312614.4	+	1	725	c.703C>T	c.(703-705)Ctt>Ttt	p.L235F		NM_001005170.2	NP_001005170.1	Q8NH67	O52I2_HUMAN	olfactory receptor, family 52, subfamily I, member 2	235					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|pancreas(1)|skin(1)	19		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGGTTCCTCTCTTATGGTGGG	0.488000													19	257					0	0	0.010504	0	0
ZNF630	57232	broad.mit.edu	37	X	47918817	47918817	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chrX:47918817C>G	ENST00000276054.4	-	5	1576	c.642G>C	c.(640-642)caG>caC	p.Q214H	ZNF630_ENST00000409324.3_Missense_Mutation_p.Q338H|ZNF630-AS1_ENST00000436124.1_RNA|ZNF630_ENST00000442455.3_Missense_Mutation_p.Q324H			Q2M218	ZN630_HUMAN	zinc finger protein 630	338					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(6)|lung(11)|ovary(1)	19						TATGGACTCTCTGATGAACAG	0.428000													8	123					0	0	0.038147	0	0
TAF1C	9013	broad.mit.edu	37	16	84214979	84214979	+	Silent	SNP	C	C	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr16:84214979C>A	ENST00000567759.1	-	10	1379	c.1197G>T	c.(1195-1197)gtG>gtT	p.V399V	TAF1C_ENST00000378541.4_Silent_p.V399V|TAF1C_ENST00000570117.1_Silent_p.V67V|TAF1C_ENST00000541676.1_Silent_p.V306V|TAF1C_ENST00000566732.1_Silent_p.V373V|TAF1C_ENST00000341690.6_Silent_p.V306V	NM_005679.3	NP_005670	Q15572	TAF1C_HUMAN	TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa	399					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding			endometrium(1)|kidney(3)|large_intestine(3)|lung(11)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	26						CCACGGTCAGCACCCGAGGGT	0.667000													6	12					0.00116845	0.00126582	0.021553	1	0
CCL23	6368	broad.mit.edu	37	17	34344932	34344932	+	Translation_Start_Site	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr17:34344932C>T	ENST00000293280.2	-	1	73	c.3G>A	c.(1-3)atG>atA	p.M1I	CCL23_ENST00000591423.1_Start_Codon_SNP_p.M1I	NM_005064.3	NP_005055.2	P55773	CCL23_HUMAN	chemokine (C-C motif) ligand 23	1					cell-cell signaling|cellular calcium ion homeostasis|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response|negative regulation of cell proliferation	extracellular space	chemokine activity|heparin binding			large_intestine(2)|liver(1)|lung(2)|prostate(1)	6		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)	Treprostinil(DB00374)	CGGAGACCTTCATCCTCCTGG	0.577000													4	28					0	0	0.014758	0	0
DNAJC3	5611	broad.mit.edu	37	13	96409943	96409943	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr13:96409943C>T	ENST00000602402.1	+	5	556	c.439C>T	c.(439-441)Caa>Taa	p.Q147*	DNAJC3_ENST00000376795.6_Intron	NM_006260.4	NP_006251.1	Q13217	DNJC3_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 3	147					protein folding|response to unfolded protein|response to virus		heat shock protein binding|protein kinase inhibitor activity|unfolded protein binding			NS(1)|breast(1)|kidney(4)|large_intestine(1)|lung(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.126)			AGCACAGTCTCAACTTATAAA	0.343000													9	90					0	0	0.004482	0	0
ZNF358	140467	broad.mit.edu	37	19	7584339	7584339	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr19:7584339C>A	ENST00000597229.1	+	2	381	c.211C>A	c.(211-213)Ctg>Atg	p.L71M	CTD-2207O23.12_ENST00000599312.1_3'UTR|ZNF358_ENST00000394341.2_Missense_Mutation_p.L71M	NM_018083.4	NP_060553.4	Q9NW07	ZN358_HUMAN	zinc finger protein 358	71					embryonic forelimb morphogenesis|neural tube development|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|lung(1)|skin(2)	8						CTCGGAGGATCTGGACCCCGA	0.607000													7	75					0.0381472	0.0404278	0.038147	1	0
NOS3	4846	broad.mit.edu	37	7	150698385	150698385	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr7:150698385G>C	ENST00000297494.3	+	11	1657	c.1300G>C	c.(1300-1302)Gag>Cag	p.E434Q	NOS3_ENST00000461406.1_Missense_Mutation_p.E228Q|NOS3_ENST00000467517.1_Missense_Mutation_p.E434Q|NOS3_ENST00000484524.1_Missense_Mutation_p.E434Q	NM_000603.4	NP_000594.2	P29474	NOS3_HUMAN	nitric oxide synthase 3 (endothelial cell)	434	Interaction with NOSIP.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(3)|breast(3)|central_nervous_system(5)|endometrium(1)|kidney(4)|large_intestine(6)|liver(2)|lung(11)|ovary(3)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	50	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	CCTGGAGAATGAGCAGAAGGC	0.612000													5	83					0	0	0.038147	0	0
KCTD11	147040	broad.mit.edu	37	17	7256592	7256592	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr17:7256592C>G	ENST00000333751.3	+	1	1385	c.331C>G	c.(331-333)Cac>Gac	p.H111D	RP11-542C16.1_ENST00000572417.1_RNA	NM_001002914.2	NP_001002914.1	Q693B1	KCD11_HUMAN	potassium channel tetramerization domain containing 11	111					cell cycle|regulation of growth	voltage-gated potassium channel complex	voltage-gated potassium channel activity			kidney(1)|large_intestine(2)|lung(1)	4		Prostate(122;0.157)				GGGACCCCATCACTATGAGCT	0.632000													6	59					0	0	0.029380	0	0
EXTL3	2137	broad.mit.edu	37	8	28575593	28575593	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr8:28575593G>A	ENST00000220562.4	+	3	2919	c.2017G>A	c.(2017-2019)Gag>Aag	p.E673K	EXTL3_ENST00000523149.1_Missense_Mutation_p.E289K|EXTL3_ENST00000519886.1_Intron	NM_001440.2	NP_001431.1	O43909	EXTL3_HUMAN	exostosin-like glycosyltransferase 3	673						integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding|protein binding			biliary_tract(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(8)|ovary(1)|prostate(2)|skin(2)|soft_tissue(1)|urinary_tract(1)	36		Ovarian(32;0.069)		KIRC - Kidney renal clear cell carcinoma(542;0.107)|Kidney(114;0.129)|Colorectal(74;0.228)		TTATGAGCGGGAGGAAGTGCT	0.542000													7	97					0	0	0.029380	0	0
MAP3K19	80122	broad.mit.edu	37	2	135739074	135739074	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:135739074G>A	ENST00000392915.1	-	10	3559	c.3440C>T	c.(3439-3441)tCa>tTa	p.S1147L	MAP3K19_ENST00000392918.3_Intron|MAP3K19_ENST00000375845.3_Silent_p.L1079L|MAP3K19_ENST00000375844.3_Silent_p.L261L|MAP3K19_ENST00000392917.3_Silent_p.L211L|MAP3K19_ENST00000358371.4_Silent_p.L966L|MAP3K19_ENST00000315513.3_5'UTR					mitogen-activated protein kinase kinase kinase 19																		CTTGACTAGTGAGACCACAGT	0.368000													7	199					0	0	0.029380	0	0
LOC653786	653786	broad.mit.edu	37	16	22588118	22588118	+	RNA	SNP	G	G	A	rs56041217	by1000genomes	TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr16:22588118G>A	ENST00000550753.1	+	0	2593					NR_003676.2																						ATCTAGGGCAGGGAAACCCTG	0.428000													4	13					0	0	0.014758	0	0
IQGAP3	128239	broad.mit.edu	37	1	156507074	156507074	+	Silent	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr1:156507074G>A	ENST00000361170.2	-	27	3331	c.3321C>T	c.(3319-3321)agC>agT	p.S1107S	IQGAP3_ENST00000498755.1_5'UTR	NM_178229.4	NP_839943.2	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	1107	Ras-GAP.				small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(14)|lung(29)|ovary(5)|prostate(5)|skin(5)|urinary_tract(3)	75	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CCTCGGGGTGGCTCAAGGCCT	0.562000													3	36					0	0	0.004672	0	0
MT-ND6	4541	broad.mit.edu	37	MT	14259	14259	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chrM:14259G>A	ENST00000361681.2	-	1	414	c.415C>T	c.(415-417)Cct>Tct	p.P139S						mitochondrially encoded NADH dehydrogenase 6											breast(1)|endometrium(10)|kidney(17)|urinary_tract(1)	29						CGCACCAATAGGATCCTCCCG	0.423000													3	10					0	0	0.014758	0	0
GLYR1	84656	broad.mit.edu	37	16	4882060	4882060	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr16:4882060C>T	ENST00000321919.9	-	5	533	c.457G>A	c.(457-459)Gag>Aag	p.E153K	GLYR1_ENST00000436648.5_Intron|GLYR1_ENST00000586901.1_5'UTR|GLYR1_ENST00000381983.3_Missense_Mutation_p.E153K|GLYR1_ENST00000591451.1_Missense_Mutation_p.E153K	NM_032569.3	NP_115958	Q49A26	GLYR1_HUMAN	glyoxylate reductase 1 homolog (Arabidopsis)	153					pentose-phosphate shunt	nucleus	coenzyme binding|DNA binding|methylated histone residue binding|phosphogluconate dehydrogenase (decarboxylating) activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(6)|prostate(2)|skin(1)|urinary_tract(1)	19						GAGCCTCTCTCTGAAGAGCCT	0.527000													11	191					0	0	0.010729	0	0
NPAT	4863	broad.mit.edu	37	11	108043955	108043955	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr11:108043955C>T	ENST00000278612.8	-	13	1861	c.1756G>A	c.(1756-1758)Gaa>Aaa	p.E586K	NPAT_ENST00000610253.1_5'UTR	NM_002519.2	NP_002510.2	Q14207	NPAT_HUMAN	nuclear protein, ataxia-telangiectasia locus	586					positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	protein C-terminus binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(21)|ovary(2)|prostate(2)|skin(5)	46		all_cancers(61;2.31e-10)|all_epithelial(67;1.11e-06)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;1.05e-05)|Epithelial(105;3.01e-05)|all cancers(92;0.000816)|Colorectal(284;0.116)		ATAACTGGTTCTAACACATTA	0.299000													14	231					0	0	0.020292	0	0
BAGE2	85319	broad.mit.edu	37	21	11058353	11058353	+	RNA	SNP	T	T	C	rs79433933	by1000genomes	TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr21:11058353T>C	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GAAATCTCTTTATAAAACCTT	0.343000													8	120					0	0	0.038147	0	0
HELZ	9931	broad.mit.edu	37	17	65162678	65162678	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr17:65162678T>A	ENST00000358691.5	-	15	1977	c.1811A>T	c.(1810-1812)cAc>cTc	p.H604L	HELZ_ENST00000580168.1_Missense_Mutation_p.H604L	NM_014877.3	NP_055692			helicase with zinc finger											NS(1)|breast(5)|endometrium(9)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					TAGTGCATAGTGCATTTCACA	0.393000													7	154					0	0	0.038147	0	0
COPE	11316	broad.mit.edu	37	19	19021838	19021838	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr19:19021838C>T	ENST00000600932.1	-	3	263	c.232G>A	c.(232-234)Gcc>Acc	p.A78T	COPE_ENST00000351079.4_Missense_Mutation_p.A78T|AC002985.3_ENST00000596918.1_3'UTR|COPE_ENST00000349893.4_Missense_Mutation_p.A78T|COPE_ENST00000598969.1_5'UTR|COPE_ENST00000262812.4_Missense_Mutation_p.A78T			O14579	COPE_HUMAN	coatomer protein complex, subunit epsilon	78					COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	binding|structural molecule activity			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	11						AGCTCAGGGGCCGAGGAGGGC	0.632000													9	156					0	0	0.004482	0	0
HGS	9146	broad.mit.edu	37	17	79660899	79660899	+	Splice_Site	SNP	G	G	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr17:79660899G>T	ENST00000329138.4	+	11	975		c.e11-1			NM_004712.4	NP_004703.1	O14964	HGS_HUMAN	hepatocyte growth factor-regulated tyrosine kinase substrate						cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of JAK-STAT cascade|regulation of protein catabolic process	cytosol|early endosome membrane|multivesicular body membrane	metal ion binding|protein domain specific binding			endometrium(2)|kidney(3)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	12	all_neural(118;0.0878)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)			TTCTGCCTCAGAGACAGAAGT	0.677000													4	38					0.00909568	0.00974537	0.009096	1	0
UGP2	7360	broad.mit.edu	37	2	64114722	64114722	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:64114722G>A	ENST00000337130.5	+	8	1734	c.1258G>A	c.(1258-1260)Gaa>Aaa	p.E420K	UGP2_ENST00000467648.2_Missense_Mutation_p.E409K|UGP2_ENST00000445915.2_Missense_Mutation_p.E429K|UGP2_ENST00000394417.2_Missense_Mutation_p.E409K	NM_006759.3	NP_006750.3	Q16851	UGPA_HUMAN	UDP-glucose pyrophosphorylase 2	420					glycogen biosynthetic process|phosphorylation|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	metal ion binding|protein binding|UTP:glucose-1-phosphate uridylyltransferase activity			endometrium(2)|kidney(1)|large_intestine(8)|lung(6)|prostate(1)	18						GACAATGAGTGAAAAGCGGGA	0.403000													12	195					0	0	0.010729	0	0
USP51	158880	broad.mit.edu	37	X	55514287	55514287	+	Silent	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chrX:55514287C>G	ENST00000500968.3	-	2	1168	c.1086G>C	c.(1084-1086)ctG>ctC	p.L362L	USP51_ENST00000586165.1_5'UTR	NM_201286.3	NP_958443.1	Q70EK9	UBP51_HUMAN	ubiquitin specific peptidase 51	362					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	30						TTAGCCCTCTCAGGCCTACAG	0.403000													15	223					0	0	0.020292	0	0
KDR	3791	broad.mit.edu	37	4	55961744	55961744	+	Splice_Site	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr4:55961744C>T	ENST00000263923.4	-	20	3112	c.2817G>A	c.(2815-2817)aaG>aaA	p.K939K		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	939	Protein kinase.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	GATGACATACCTTGTAGGGGA	0.413000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			8	99					0	0	0.004482	0	0
PLEKHG3	26030	broad.mit.edu	37	14	65198166	65198166	+	Missense_Mutation	SNP	C	C	T	rs145887123		TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr14:65198166C>T	ENST00000247226.7	+	6	1077	c.769C>T	c.(769-771)Cgc>Tgc	p.R257C	PLEKHG3_ENST00000394691.1_Missense_Mutation_p.R313C	NM_015549.1	NP_056364.1	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	313	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(5)|kidney(2)|large_intestine(1)|lung(14)|prostate(2)|skin(3)|urinary_tract(2)	29				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		CCGCGTGCATCGCGTGCGCAA	0.552000													5	67					0	0	0.014758	0	0
PGM2L1	283209	broad.mit.edu	37	11	74056622	74056622	+	Silent	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr11:74056622C>T	ENST00000298198.4	-	9	1421	c.1110G>A	c.(1108-1110)aaG>aaA	p.K370K		NM_173582.3	NP_775853.2	Q6PCE3	PGM2L_HUMAN	phosphoglucomutase 2-like 1	370					glucose 1-phosphate metabolic process	cytosol	glucose-1,6-bisphosphate synthase activity|phosphoglucomutase activity			NS(2)|breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	Breast(11;3.32e-06)					ATTTATTTTTCTTCCAGCAAT	0.373000													5	108					0	0	0.021553	0	0
TCP11	6954	broad.mit.edu	37	6	35088708	35088708	+	Silent	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr6:35088708C>T	ENST00000311875.5	-	6	1149	c.732G>A	c.(730-732)caG>caA	p.Q244Q	TCP11_ENST00000412155.2_Silent_p.Q193Q|TCP11_ENST00000512012.1_Silent_p.Q231Q|TCP11_ENST00000418521.2_Silent_p.Q168Q|TCP11_ENST00000244645.3_Silent_p.Q169Q|TCP11_ENST00000373979.2_Silent_p.Q169Q|TCP11_ENST00000373974.4_Silent_p.Q198Q|TCP11_ENST00000444780.2_Silent_p.Q239Q			Q8WWU5	TCP11_HUMAN	t-complex 11, testis-specific	231					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(1)|kidney(5)|large_intestine(3)|lung(10)|ovary(3)|prostate(1)|skin(4)	27						TGAGGAGTTCCTGGAATTTAG	0.443000													45	534					0	0	0.014410	0	0
STAG2	10735	broad.mit.edu	37	X	123179197	123179197	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chrX:123179197C>T	ENST00000371160.1	+	8	936	c.646C>T	c.(646-648)Cga>Tga	p.R216*	STAG2_ENST00000218089.9_Nonsense_Mutation_p.R216*|STAG2_ENST00000469481.1_Intron|STAG2_ENST00000371144.3_Nonsense_Mutation_p.R216*|STAG2_ENST00000371145.3_Nonsense_Mutation_p.R216*|STAG2_ENST00000354548.5_Nonsense_Mutation_p.R147*|STAG2_ENST00000371157.3_Nonsense_Mutation_p.R216*	NM_001282418.1	NP_001269347.1	Q8N3U4	STAG2_HUMAN	stromal antigen 2	216					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(9)|lung(21)|ovary(5)|prostate(2)|skin(5)|urinary_tract(4)	78						CAGAGCATTTCGACATACAAG	0.343000													20	335					0	0	0.010504	0	0
ZNF491	126069	broad.mit.edu	37	19	11916920	11916920	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr19:11916920C>T	ENST00000323169.5	+	3	483	c.152C>T	c.(151-153)tCc>tTc	p.S51F	ZNF491_ENST00000492230.1_Intron	NM_152356.3	NP_689569.2	Q8N8L2	ZN491_HUMAN	zinc finger protein 491	51					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(14)|lung(6)|ovary(2)|skin(1)	26						GGATATTCATCCTTTAATAGG	0.393000													6	111					0	0	0.038147	0	0
KARS	3735	broad.mit.edu	37	16	75669626	75669626	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr16:75669626C>G	ENST00000319410.5	-	7	952	c.831G>C	c.(829-831)aaG>aaC	p.K277N	KARS_ENST00000302445.3_Missense_Mutation_p.K249N|KARS_ENST00000568378.1_Intron	NM_001130089.1	NP_001123561.1	Q15046	SYK_HUMAN	lysyl-tRNA synthetase	249					interspecies interaction between organisms|lysyl-tRNA aminoacylation|tRNA processing	cytosol|extracellular region|mitochondrial matrix|nucleus|plasma membrane|soluble fraction	ATP binding|lysine-tRNA ligase activity|metal ion binding|tRNA binding			kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	18					L-Lysine(DB00123)	ATGTGATGATCTTAGAGCGGA	0.433000													9	88					0	0	0.006214	0	0
C12orf66	144577	broad.mit.edu	37	12	64588249	64588249	+	Silent	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr12:64588249C>T	ENST00000311915.8	-	3	738	c.711G>A	c.(709-711)aaG>aaA	p.K237K	C12orf66_ENST00000544871.1_Silent_p.K184K|C12orf66_ENST00000398055.3_Silent_p.K237K			Q96MD2	CL066_HUMAN	chromosome 12 open reading frame 66	237										central_nervous_system(1)|large_intestine(1)|lung(2)|ovary(1)	5						ACAGATGTTTCTTGGTCTCCC	0.493000													8	66					0	0	0.004482	0	0
RP11-407N17.3	0	broad.mit.edu	37	14	39716635	39716635	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr14:39716635C>T	ENST00000553728.1	+	4	1070	c.857C>T	c.(856-858)tCa>tTa	p.S286L	MIA2_ENST00000556784.1_Missense_Mutation_p.S285L|MIA2_ENST00000280082.3_Missense_Mutation_p.S286L																							GAAATTGATTCAGTGCCAAAG	0.398000													7	91					0	0	0.029380	0	0
XYLB	9942	broad.mit.edu	37	3	38404477	38404477	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr3:38404477C>T	ENST00000207870.3	+	4	350	c.260C>T	c.(259-261)tCt>tTt	p.S87F	XYLB_ENST00000542835.1_Intron	NM_005108.3	NP_005099.2	O75191	XYLB_HUMAN	xylulokinase homolog (H. influenzae)	87					D-xylose metabolic process|generation of precursor metabolites and energy|xylulose catabolic process		ATP binding|xylulokinase activity			endometrium(3)|kidney(3)|large_intestine(3)|liver(1)|lung(12)|ovary(1)|prostate(1)	24				KIRC - Kidney renal clear cell carcinoma(284;0.00372)|Kidney(284;0.00405)		TTCGACTTCTCTCAAGTCCTA	0.522000													4	119					0	0	0.014758	0	0
ACVRL1	94	broad.mit.edu	37	12	52309201	52309201	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr12:52309201G>A	ENST00000550683.1	+	6	1108	c.1007G>A	c.(1006-1008)gGc>gAc	p.G336D	ACVRL1_ENST00000419526.2_Missense_Mutation_p.G148D|ACVRL1_ENST00000388922.4_Missense_Mutation_p.G322D	NM_001077401.1	NP_001070869.1	P37023	ACVL1_HUMAN	activin A receptor type II-like 1	322	Protein kinase.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|blood vessel maturation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of endothelial cell migration|negative regulation of focal adhesion assembly|positive regulation of BMP signaling pathway|positive regulation of transcription, DNA-dependent|regulation of blood pressure|regulation of blood vessel endothelial cell migration|regulation of DNA replication|regulation of endothelial cell proliferation|transforming growth factor beta receptor signaling pathway|wound healing, spreading of epidermal cells	cell surface|integral to plasma membrane	activin binding|activin receptor activity, type I|ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	20				BRCA - Breast invasive adenocarcinoma(357;0.0991)	Adenosine triphosphate(DB00171)	GGTACACAGGGCAAACCAGCC	0.642000													3	25					0	0	0.014758	0	0
MAP6	4135	broad.mit.edu	37	11	75298367	75298367	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr11:75298367G>C	ENST00000304771.3	-	4	2929	c.2179C>G	c.(2179-2181)Caa>Gaa	p.Q727E	CTD-2530H12.4_ENST00000527803.1_RNA|MAP6_ENST00000526740.1_Missense_Mutation_p.Q398E	NM_033063.1	NP_149052.1	Q96JE9	MAP6_HUMAN	microtubule-associated protein 6	727	Pro-rich.					Golgi apparatus|microtubule|perinuclear region of cytoplasm	calmodulin binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|prostate(1)|skin(1)|urinary_tract(1)	19	Ovarian(111;0.11)					GTGGGGCCTTGATCCTTAACT	0.493000													25	221					0	0	0.018920	0	0
LRRC46	90506	broad.mit.edu	37	17	45912735	45912735	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr17:45912735T>C	ENST00000269025.4	+	4	605	c.242T>C	c.(241-243)aTt>aCt	p.I81T		NM_033413.3	NP_219481.1	Q96FV0	LRC46_HUMAN	leucine rich repeat containing 46	81										endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)	9						ATCCAGCAAATTGAGAACCTG	0.547000													21	195					0	0	0.016522	0	0
FASTKD1	79675	broad.mit.edu	37	2	170416964	170416964	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:170416964G>A	ENST00000453153.2	-	5	1250	c.904C>T	c.(904-906)Cat>Tat	p.H302Y	FASTKD1_ENST00000453929.2_Missense_Mutation_p.H302Y	NM_024622.3	NP_078898.3	Q53R41	FAKD1_HUMAN	FAST kinase domains 1	302					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(5)|large_intestine(10)|lung(9)|ovary(4)|prostate(3)	37						CTAGCAGGATGATTACACAGA	0.299000													18	239					0	0	0.008871	0	0
F8	2157	broad.mit.edu	37	X	154197729	154197729	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chrX:154197729G>A	ENST00000360256.4	-	7	1086	c.886C>T	c.(886-888)Ctt>Ttt	p.L296F		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	296	F5/8 type A 1.|Plastocyanin-like 2.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TTCCTCACAAGAAATGTGTGA	0.463000													12	195					0	0	0.028581	0	0
LOC102724710	102724710	broad.mit.edu	37	8	93591561	93591562	+	RNA	INS	-	-	TTTC	rs34835405		TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr8:93591561_93591562insTTTC	ENST00000523284.1	-	0	395																											ctttctttctttttctttcttt	0.312													4	2	---	---	---	---					
RP11-25I15.2	0	broad.mit.edu	37	12	43072603	43072603	+	RNA	DEL	T	T	-			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr12:43072603delT	ENST00000548764.1	+	0	465																											AGAACTCTGCttttttttttt	0.413													5	9	---	---	---	---					
KDM6A	7403	broad.mit.edu	37	X	44938507	44938507	+	Frame_Shift_Del	DEL	A	A	-			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chrX:44938507delA	ENST00000377967.4	+	20	3096	c.3055delA	c.(3055-3057)aaafs	p.K1019fs	KDM6A_ENST00000536777.1_Frame_Shift_Del_p.K974fs|KDM6A_ENST00000543216.1_Frame_Shift_Del_p.K940fs|KDM6A_ENST00000382899.4_Frame_Shift_Del_p.K1026fs	NM_021140.2	NP_066963.2	O15550	KDM6A_HUMAN	lysine (K)-specific demethylase 6A	1019					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0?(6)		NS(1)|breast(7)|central_nervous_system(27)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(24)|kidney(24)|large_intestine(9)|liver(1)|lung(21)|oesophagus(11)|pancreas(2)|prostate(5)|skin(1)|soft_tissue(1)|urinary_tract(29)	170						TGGAACAAAGAAAATCTGGCA	0.398			"""D, N, F, S"""		"""renal, oesophageal SCC, MM"""								7	106	---	---	---	---