Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CYP2A7	1549	broad.mit.edu	37	19	41383142	41383142	+	Missense_Mutation	SNP	G	G	A	rs151290022		TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr19:41383142G>A	ENST00000301146.4	-	7	1655	c.1114C>T	c.(1114-1116)Cgc>Tgc	p.R372C	CYP2A7_ENST00000291764.3_Missense_Mutation_p.R321C|CTC-490E21.12_ENST00000601627.1_Intron	NM_000764.2	NP_000755.2	P20853	CP2A7_HUMAN	cytochrome P450, family 2, subfamily A, polypeptide 7	372						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			TTAACCCTGCGGGCCAAACTC	0.547000													54	116					0	0	1	0	0
FAM171B	165215	broad.mit.edu	37	2	187626455	187626455	+	Silent	SNP	C	C	T			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr2:187626455C>T	ENST00000304698.5	+	8	1589	c.1386C>T	c.(1384-1386)atC>atT	p.I462I		NM_177454.3	NP_803237.3	Q6P995	F171B_HUMAN	family with sequence similarity 171, member B	462						integral to membrane	DNA binding			NS(1)|breast(6)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(22)|ovary(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						ATTTTAAAATCTACAATGAAG	0.368000													19	49					0	0	1	0	0
GALNT2	2590	broad.mit.edu	37	1	230384989	230384989	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr1:230384989C>T	ENST00000366672.4	+	9	949	c.877C>T	c.(877-879)Cgg>Tgg	p.R293W	GALNT2_ENST00000543760.1_Missense_Mutation_p.R255W|GALNT2_ENST00000541865.1_Missense_Mutation_p.R203W	NM_004481.3	NP_004472.1	Q10471	GALT2_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)	293				R -> Q (in Ref. 1; AA sequence).	immunoglobulin biosynthetic process|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(5)|skin(2)	32	Breast(184;0.193)|Ovarian(103;0.249)	all_cancers(173;0.156)|Prostate(94;0.179)				GAGAAGGTCCCGGCAGGGGAA	0.552000													34	69					0	0	1	0	0
RP11-423O2.5	0	broad.mit.edu	37	1	142803543	142803543	+	RNA	SNP	C	C	T			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr1:142803543C>T	ENST00000423385.1	-	0	1422																											TGTTGGAATTCCTGATGAATC	0.269000													5	132					0	0	1	0	0
ADSSL1	122622	broad.mit.edu	37	14	105209437	105209437	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr14:105209437G>A	ENST00000332972.5	+	10	1270	c.1111G>A	c.(1111-1113)Gag>Aag	p.E371K	ADSSL1_ENST00000330877.2_Missense_Mutation_p.E328K	NM_199165.1	NP_954634.1	Q8N142	PURA1_HUMAN	adenylosuccinate synthase like 1	328					AMP biosynthetic process|immune system process|purine base metabolic process	cytosol	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			central_nervous_system(1)|cervix(1)|kidney(1)|lung(5)|ovary(2)|prostate(1)	11		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00153)|OV - Ovarian serous cystadenocarcinoma(23;0.0148)|Epithelial(46;0.0396)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.18)	L-Aspartic Acid(DB00128)	CCGCGGCCACGAGTGGGGAGT	0.597000													71	67					0	0	1	0	0
CD6	923	broad.mit.edu	37	11	60780898	60780898	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr11:60780898C>T	ENST00000313421.7	+	7	1340	c.1154C>T	c.(1153-1155)tCt>tTt	p.S385F	CD6_ENST00000352009.5_Missense_Mutation_p.S385F|CD6_ENST00000452451.2_Missense_Mutation_p.S385F|CD6_ENST00000346437.4_Missense_Mutation_p.S385F|CD6_ENST00000344028.5_Missense_Mutation_p.S385F|CD6_ENST00000545105.1_3'UTR	NM_006725.4	NP_006716.3	P30203	CD6_HUMAN	CD6 molecule	385					cell adhesion	cell surface|integral to plasma membrane	scavenger receptor activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)	18						TTTCCAGAATCTTCTGTGACA	0.463000													97	115					0	0	1	0	0
SLC11A2	4891	broad.mit.edu	37	12	51402369	51402369	+	Missense_Mutation	SNP	C	C	A			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr12:51402369C>A	ENST00000394904.3	-	3	209	c.160G>T	c.(160-162)Ggt>Tgt	p.G54C	SLC11A2_ENST00000549193.1_5'UTR|SLC11A2_ENST00000262052.5_Missense_Mutation_p.G25C|SLC11A2_ENST00000545993.2_Missense_Mutation_p.G21C|SLC11A2_ENST00000547688.1_Missense_Mutation_p.G54C|SLC11A2_ENST00000262051.7_Missense_Mutation_p.G25C|SLC11A2_ENST00000547198.1_Missense_Mutation_p.G25C|SLC11A2_ENST00000541174.2_Missense_Mutation_p.G25C|SLC11A2_ENST00000546743.1_Intron	NM_001174125.1	NP_001167596.1	P49281	NRAM2_HUMAN	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2	25					activation of caspase activity|cellular iron ion homeostasis|cellular response to oxidative stress|detection of oxygen|ferrous iron import|multicellular organismal iron ion homeostasis|response to hypoxia|response to iron ion	apical plasma membrane|basal part of cell|cell surface|cytoplasmic vesicle|early endosome|late endosome|late endosome membrane|lysosomal membrane|lysosome|nucleus|paraferritin complex|perinuclear region of cytoplasm|plasma membrane|recycling endosome|trans-Golgi network	cadmium ion transmembrane transporter activity|cobalt ion transmembrane transporter activity|copper ion transmembrane transporter activity|ferrous iron transmembrane transporter activity|lead ion transmembrane transporter activity|manganese ion transmembrane transporter activity|nickel ion transmembrane transporter activity|protein binding|solute:hydrogen symporter activity|vanadium ion transmembrane transporter activity|zinc ion transmembrane transporter activity			breast(2)|cervix(1)|endometrium(3)|kidney(16)|large_intestine(4)|lung(9)|upper_aerodigestive_tract(1)	36						TTGATGTTACCAAGACTGGCA	0.398000													4	134					0.150653	0.151859	1	1	0
PRKDC	5591	broad.mit.edu	37	8	48716043	48716043	+	Splice_Site	SNP	T	T	C			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr8:48716043T>C	ENST00000314191.2	-	71	9801		c.e71-2		PRKDC_ENST00000523565.1_Splice_Site|PRKDC_ENST00000338368.3_Splice_Site	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide						cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				GAAATTGTTCTGTATGAATAC	0.443000								Non-homologous end-joining					59	185					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55892660	55892660	+	Missense_Mutation	SNP	A	A	T			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr10:55892660A>T	ENST00000373965.2	-	16	2307	c.1913T>A	c.(1912-1914)gTt>gAt	p.V638D	PCDH15_ENST00000320301.6_Missense_Mutation_p.V631D|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000361849.3_Missense_Mutation_p.V631D|PCDH15_ENST00000395446.1_Missense_Mutation_p.V631D|PCDH15_ENST00000395433.1_Missense_Mutation_p.V609D|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000395445.1_Missense_Mutation_p.V638D|PCDH15_ENST00000414778.1_Missense_Mutation_p.V636D|PCDH15_ENST00000373955.1_Missense_Mutation_p.V631D|PCDH15_ENST00000373957.3_Missense_Mutation_p.V609D|PCDH15_ENST00000395438.1_Missense_Mutation_p.V631D|PCDH15_ENST00000437009.1_Intron|PCDH15_ENST00000395430.1_Missense_Mutation_p.V631D|PCDH15_ENST00000409834.1_Missense_Mutation_p.V242D|PCDH15_ENST00000395432.2_Missense_Mutation_p.V594D	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	631	Cadherin 6.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				AACAGCACCAACCCTCATGGC	0.398000										HNSCC(58;0.16)			13	19					0	0	1	0	0
PIGQ	9091	broad.mit.edu	37	16	633482	633482	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr16:633482C>T	ENST00000026218.5	+	10	2219	c.2131C>T	c.(2131-2133)Ccc>Tcc	p.P711S	PIGQ_ENST00000321878.5_3'UTR	NM_148920.2	NP_683721.1	Q9BRB3	PIGQ_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class Q	711					C-terminal protein lipidation|carbohydrate metabolic process|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	13		Hepatocellular(780;0.00335)				ACCCCCCAGTCCCAGGCACCC	0.701000													33	41					0	0	1	0	0
DNAJC10	54431	broad.mit.edu	37	2	183594593	183594593	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr2:183594593G>A	ENST00000264065.7	+	8	1067	c.652G>A	c.(652-654)Gga>Aga	p.G218R	DNAJC10_ENST00000537515.1_Missense_Mutation_p.G218R	NM_018981.1	NP_061854.1	Q8IXB1	DJC10_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 10		Thioredoxin 1.				apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|ER-associated protein catabolic process|glycerol ether metabolic process|negative regulation of protein phosphorylation|protein folding|response to endoplasmic reticulum stress	endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|extracellular region	ATPase activator activity|ATPase binding|chaperone binding|electron carrier activity|heat shock protein binding|misfolded protein binding|protein disulfide oxidoreductase activity|unfolded protein binding			breast(3)|endometrium(1)|kidney(4)|large_intestine(7)|lung(15)|ovary(1)|skin(1)	32			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			GAAATATCATGGAGACAGATC	0.308000													49	64					0	0	1	0	0
MT-ATP6	4508	broad.mit.edu	37	MT	9064	9064	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chrM:9064G>C	ENST00000361899.2	+	1	538	c.538G>C	c.(538-540)Gca>Cca	p.A180P						mitochondrially encoded ATP synthase 6											breast(2)|endometrium(7)|kidney(8)|prostate(1)	18						GCGCCACCCTAGCAATATCAA	0.468000													4	1					0	0	1	0	0
MTA1	9112	broad.mit.edu	37	14	105930894	105930894	+	Missense_Mutation	SNP	G	G	T			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr14:105930894G>T	ENST00000331320.7	+	14	1548	c.1334G>T	c.(1333-1335)cGc>cTc	p.R445L	MTA1_ENST00000435036.2_5'UTR|MTA1_ENST00000405646.1_Missense_Mutation_p.R428L|MTA1_ENST00000406191.1_Missense_Mutation_p.R445L	NM_001203258.1|NM_004689.3	NP_001190187.1|NP_004680.2	Q13330	MTA1_HUMAN	metastasis associated 1	445					signal transduction	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|stomach(1)	14		all_cancers(154;0.0293)|all_epithelial(191;0.128)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00897)|Epithelial(46;0.026)	Epithelial(152;0.19)		GGACCAAACCGCAGTAACATG	0.597000													23	35					5.35356e-11	5.96945e-11	1	1	0
MPPED2	744	broad.mit.edu	37	11	30601899	30601899	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr11:30601899G>C	ENST00000448418.2	-	2	382	c.22C>G	c.(22-24)Caa>Gaa	p.Q8E	MPPED2_ENST00000358117.5_Missense_Mutation_p.Q8E	NM_001145399.1	NP_001138871.1	Q15777	MPPD2_HUMAN	metallophosphoesterase domain containing 2	8					nervous system development		hydrolase activity|metal ion binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|liver(1)|lung(15)|skin(2)|upper_aerodigestive_tract(2)	33						ACTTTGCCTTGAGAAGGAATC	0.493000													31	4					0	0	1	0	0
OR4M2	390538	broad.mit.edu	37	15	22368671	22368671	+	Silent	SNP	A	A	T			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr15:22368671A>T	ENST00000332663.2	+	1	194	c.96A>T	c.(94-96)ctA>ctT	p.L32L	RP11-69H14.6_ENST00000558896.1_RNA	NM_001004719.2	NP_001004719.2	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M, member 2	32					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(38)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	63		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TTATATTTCTATCCTTCTATT	0.403000													89	189					0	0	1	0	0
GABRB1	2560	broad.mit.edu	37	4	47163454	47163454	+	Silent	SNP	G	G	T			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr4:47163454G>T	ENST00000295454.3	+	4	721	c.429G>T	c.(427-429)ctG>ctT	p.L143L	GABRB1_ENST00000538619.1_Silent_p.L73L	NM_000812.3	NP_000803.2	P18505	GBRB1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 1	143					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44					Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	TGATTCGACTGCATCCTGATG	0.393000													41	158					5.44703e-19	6.29656e-19	1	1	0
OR4M2	390538	broad.mit.edu	37	15	22368696	22368696	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr15:22368696G>A	ENST00000332663.2	+	1	219	c.121G>A	c.(121-123)Gga>Aga	p.G41R	RP11-69H14.6_ENST00000558896.1_RNA	NM_001004719.2	NP_001004719.2	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M, member 2	41					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(38)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	63		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CATCCTACCAGGAAATATCCT	0.418000													108	248					0	0	1	0	0
LPHN2	23266	broad.mit.edu	37	1	82450313	82450313	+	Missense_Mutation	SNP	G	G	T			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr1:82450313G>T	ENST00000370728.1	+	22	3962	c.3317G>T	c.(3316-3318)gGa>gTa	p.G1106V	LPHN2_ENST00000370730.1_Missense_Mutation_p.G1106V|LPHN2_ENST00000394879.1_Missense_Mutation_p.G1108V|LPHN2_ENST00000335786.5_Missense_Mutation_p.G1106V|LPHN2_ENST00000370721.1_Missense_Mutation_p.G1031V|LPHN2_ENST00000319517.6_Missense_Mutation_p.G1093V|LPHN2_ENST00000370727.1_Missense_Mutation_p.G1121V|LPHN2_ENST00000370717.2_Missense_Mutation_p.G1121V|LPHN2_ENST00000370725.1_Missense_Mutation_p.G1121V|LPHN2_ENST00000370715.1_Missense_Mutation_p.G1093V|LPHN2_ENST00000370723.1_Missense_Mutation_p.G1108V|LPHN2_ENST00000469377.2_Intron|LPHN2_ENST00000359929.3_Missense_Mutation_p.G1093V|LPHN2_ENST00000370713.1_Missense_Mutation_p.G1093V|LPHN2_ENST00000271029.4_Missense_Mutation_p.G1121V			O95490	LPHN2_HUMAN	latrophilin 2	1106					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		TACTGCTGTGGAGGCCTCCCA	0.463000													63	76					6.75472e-32	8.0292e-32	1	1	0
MDM1	56890	broad.mit.edu	37	12	68696517	68696517	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr12:68696517G>C	ENST00000303145.7	-	12	1941	c.1855C>G	c.(1855-1857)Cca>Gca	p.P619A	MDM1_ENST00000411698.2_Missense_Mutation_p.P584A|MDM1_ENST00000540418.1_Missense_Mutation_p.P339A	NM_017440.4	NP_059136.2	Q8TC05	MDM1_HUMAN	Mdm1 nuclear protein homolog (mouse)	619						nucleus				breast(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|prostate(2)|skin(7)	33			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000174)		GGGTATTTTGGAATTTTTGAA	0.458000													49	1547					0	0	1	0	0
TFAP2D	83741	broad.mit.edu	37	6	50682838	50682838	+	Missense_Mutation	SNP	G	G	T			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr6:50682838G>T	ENST00000008391.3	+	2	277	c.49G>T	c.(49-51)Gac>Tac	p.D17Y		NM_172238.3	NP_758438.2	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 delta (activating enhancer binding protein 2 delta)	17							DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(12)|lung(26)|ovary(6)|pancreas(1)|prostate(5)|stomach(1)	60	Lung NSC(77;0.0334)					GATACGTCACGACGGATCAAA	0.517000													35	101					7.83172e-31	9.2224e-31	1	1	0
TNPO3	23534	broad.mit.edu	37	7	128645214	128645214	+	Splice_Site	SNP	C	C	A			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr7:128645214C>A	ENST00000393245.1	-	5	926		c.e5-1		TNPO3_ENST00000471234.1_Splice_Site|TNPO3_ENST00000265388.5_Splice_Site|TNPO3_ENST00000482320.1_Splice_Site|TNPO3_ENST00000471166.1_Splice_Site	NM_012470.3	NP_036602.1	Q9Y5L0	TNPO3_HUMAN	transportin 3						splicing factor protein import into nucleus	cytoplasm|nucleus	protein binding|receptor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(7)|ovary(2)|prostate(2)|skin(3)	22						CACAGGTCATCTGAATAGAGA	0.303000													28	47					3.73148e-12	4.19791e-12	1	1	0
PIGQ	9091	broad.mit.edu	37	16	633559	633559	+	Silent	SNP	C	C	T			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr16:633559C>T	ENST00000026218.5	+	10	2296	c.2208C>T	c.(2206-2208)ccC>ccT	p.P736P	PIGQ_ENST00000321878.5_3'UTR	NM_148920.2	NP_683721.1	Q9BRB3	PIGQ_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class Q	736					C-terminal protein lipidation|carbohydrate metabolic process|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	13		Hepatocellular(780;0.00335)				CCCCCGTCCCCAGCGGGCCCG	0.622000													42	60					0	0	1	0	0
ATP13A1	57130	broad.mit.edu	37	19	19774149	19774149	+	Silent	SNP	G	G	T			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr19:19774149G>T	ENST00000357324.6	-	1	353	c.327C>A	c.(325-327)ctC>ctA	p.L109L		NM_020410.2	NP_065143.2	Q9HD20	AT131_HUMAN	ATPase type 13A1	109					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						GCGCGTGCGCGAGGCAGATGG	0.692000													5	8					0.0215528	0.0219004	1	1	0
PPFIA2	8499	broad.mit.edu	37	12	81833788	81833788	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr12:81833788G>A	ENST00000550584.2	-	6	903	c.608C>T	c.(607-609)tCt>tTt	p.S203F	PPFIA2_ENST00000443686.3_Intron|PPFIA2_ENST00000552948.1_Missense_Mutation_p.S203F|PPFIA2_ENST00000407050.4_Missense_Mutation_p.S129F|PPFIA2_ENST00000549396.1_Missense_Mutation_p.S203F|PPFIA2_ENST00000545296.2_5'UTR|PPFIA2_ENST00000550359.2_Missense_Mutation_p.S50F|PPFIA2_ENST00000548586.1_Missense_Mutation_p.S203F|PPFIA2_ENST00000549325.1_Missense_Mutation_p.S185F|PPFIA2_ENST00000333447.7_Missense_Mutation_p.S185F|RP11-315E17.1_ENST00000550272.1_RNA	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	129										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						TTCCAGTGCAGAGACTCTTTC	0.413000													5	20					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142627453	142627453	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr7:142627453G>A	ENST00000265310.1	-	2	565	c.217C>T	c.(217-219)Cga>Tga	p.R73*	TRPV5_ENST00000442623.1_Nonsense_Mutation_p.R73*	NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	73					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					CCTCTTTGTCGAACGTCACAG	0.507000													36	59					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149512310	149512310	+	RNA	SNP	C	C	T			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr7:149512310C>T	ENST00000378016.2	+	0	10630							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GCCCTGCCCCCGCTCCTGCCA	0.677000													36	45					0	0	1	0	0
SLC52A3	113278	broad.mit.edu	37	20	746035	746035	+	Silent	SNP	C	C	T			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr20:746035C>T	ENST00000381944.3	-	2	625	c.384G>A	c.(382-384)ccG>ccA	p.P128P	SLC52A3_ENST00000217254.7_Silent_p.P128P|SLC52A3_ENST00000473664.1_5'UTR			Q9NQ40	RFT2_HUMAN	solute carrier family 52 (riboflavin transporter), member 3	128					sensory perception of sound	integral to plasma membrane	riboflavin transporter activity										GGCTCATGAACGGCAGGAAGG	0.632000													18	33					0	0	1	0	0
LTBP3	4054	broad.mit.edu	37	11	65320683	65320683	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr11:65320683C>T	ENST00000301873.5	-	5	1283	c.1015G>A	c.(1015-1017)Gct>Act	p.A339T	LTBP3_ENST00000536982.1_Intron|LTBP3_ENST00000322147.4_Missense_Mutation_p.A339T	NM_001130144.2	NP_001123616.1	Q9NS15	LTBP3_HUMAN	latent transforming growth factor beta binding protein 3	339						extracellular region	calcium ion binding|growth factor binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|prostate(2)|upper_aerodigestive_tract(3)	23						GGACAGTCAGCGCCCACTTCC	0.627000													35	77					0	0	1	0	0
FAM213A	84293	broad.mit.edu	37	10	82185631	82185631	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr10:82185631G>A	ENST00000372181.1	+	3	750	c.280G>A	c.(280-282)Gat>Aat	p.D94N	FAM213A_ENST00000372188.1_Missense_Mutation_p.D94N|FAM213A_ENST00000372187.5_Missense_Mutation_p.D94N|FAM213A_ENST00000372185.1_Missense_Mutation_p.D83N	NM_001243778.1|NM_001243782.1	NP_001230707.1|NP_001230711.1	Q9BRX8	CJ058_HUMAN	family with sequence similarity 213, member A	94						extracellular region											GGAAGCTGCGGATCTGTCCTC	0.567000													4	92					0	0	1	0	0
WDPCP	51057	broad.mit.edu	37	2	63609079	63609079	+	Missense_Mutation	SNP	T	T	G			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr2:63609079T>G	ENST00000409120.1	-	5	4560	c.1010A>C	c.(1009-1011)aAc>aCc	p.N337T	WDPCP_ENST00000409562.3_Missense_Mutation_p.N529T|WDPCP_ENST00000398544.3_Missense_Mutation_p.N370T|WDPCP_ENST00000409199.1_Missense_Mutation_p.N337T|WDPCP_ENST00000272321.7_Missense_Mutation_p.N529T|WDPCP_ENST00000409835.1_5'UTR			O95876	FRITZ_HUMAN	WD repeat containing planar cell polarity effector	529					cilium morphogenesis|regulation of embryonic cell shape|regulation of protein localization|septin cytoskeleton organization	cilium axoneme|cytoplasm|cytoskeleton|plasma membrane				central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(19)|ovary(1)|skin(1)	35						AAGAAGATGGTTTACAATGGC	0.398000													34	37					0	0	1	0	0
ZNF814	730051	broad.mit.edu	37	19	58385546	58385546	+	Missense_Mutation	SNP	G	G	T			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr19:58385546G>T	ENST00000435989.2	-	3	1446	c.1212C>A	c.(1210-1212)gaC>gaA	p.D404E	ZNF814_ENST00000595295.1_Intron|ZNF814_ENST00000596604.1_Intron|ZNF814_ENST00000600634.1_Intron|ZNF814_ENST00000597832.1_Intron|ZNF814_ENST00000597342.1_Intron	NM_001144989.1	NP_001138461.1	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	404					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.D404E(10)		NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						AATGTTTTTTGTCAGTGTGAA	0.393000													4	10					0.00909568	0.00931753	1	1	0
MSH4	4438	broad.mit.edu	37	1	76313915	76313915	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr1:76313915C>G	ENST00000263187.3	+	8	1288	c.1184C>G	c.(1183-1185)aCa>aGa	p.T395R		NM_002440.3	NP_002431.2	O15457	MSH4_HUMAN	mutS homolog 4	395					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			breast(1)|endometrium(2)|kidney(4)|large_intestine(9)|lung(26)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	47						TTTCTTGATACAGAGCAGCTT	0.269000								Mismatch excision repair (MMR)					20	31					0	0	1	0	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	rs121913530		TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr12:25398285C>A	ENST00000311936.3	-	2	225	c.34G>T	c.(34-36)Ggt>Tgt	p.G12C	KRAS_ENST00000556131.1_Missense_Mutation_p.G12C|KRAS_ENST00000256078.4_Missense_Mutation_p.G12C|KRAS_ENST00000557334.1_Missense_Mutation_p.G12C	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348000	G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			17	15					1.99824e-07	2.1705e-07	1	1	0
GRM7	2917	broad.mit.edu	37	3	6903420	6903420	+	Silent	SNP	G	G	A			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr3:6903420G>A	ENST00000486284.1	+	1	619	c.345G>A	c.(343-345)gcG>gcA	p.A115A	GRM7_ENST00000402647.2_Silent_p.A115A|GRM7_ENST00000403881.1_Silent_p.A115A|GRM7_ENST00000357716.4_Silent_p.A115A|GRM7_ENST00000389336.4_Silent_p.A115A	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	115					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	ACACTTACGCGCTCGAACAGT	0.607000													43	40					0	0	1	0	0
PHF13	148479	broad.mit.edu	37	1	6681670	6681670	+	Silent	SNP	G	G	A			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr1:6681670G>A	ENST00000377648.4	+	4	1258	c.876G>A	c.(874-876)acG>acA	p.T292T	PHF13_ENST00000495385.1_Intron	NM_153812.2	NP_722519.2	Q86YI8	PHF13_HUMAN	PHD finger protein 13	292					cell division|chromatin modification|mitotic chromosome condensation	nucleoplasm	chromatin binding|methylated histone residue binding|zinc ion binding			endometrium(3)|large_intestine(1)|lung(3)	7	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;1.46e-33)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.19e-07)|COAD - Colon adenocarcinoma(227;1.3e-05)|Kidney(185;4.88e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000501)|KIRC - Kidney renal clear cell carcinoma(229;0.000871)|STAD - Stomach adenocarcinoma(132;0.0165)|READ - Rectum adenocarcinoma(331;0.0642)		GCTCGCGGACGGGCTCCCGGA	0.582000													21	49					0	0	1	0	0
HSP90AB2P	391634	broad.mit.edu	37	4	13338075	13338075	+	RNA	SNP	C	C	G			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr4:13338075C>G	ENST00000602906.1	+	0	123																				kidney(3)|lung(1)	4						CTACCTTGCTCTTTAATACGT	0.502000													7	29					0	0	1	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128842667	128842667	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr11:128842667G>A	ENST00000310343.9	-	21	3691	c.3692C>T	c.(3691-3693)gCa>gTa	p.A1231V	ARHGAP32_ENST00000524655.1_3'UTR|ARHGAP32_ENST00000527272.1_Missense_Mutation_p.A882V|ARHGAP32_ENST00000392657.3_Missense_Mutation_p.A882V	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	1231					cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						AGATTTGTCTGCAAATTCTAA	0.478000													4	88					0	0	1	0	0
EML5	161436	broad.mit.edu	37	14	89148322	89148322	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr14:89148322G>C	ENST00000554922.1	-	21	3284	c.3036C>G	c.(3034-3036)atC>atG	p.I1012M	EML5_ENST00000352093.5_Missense_Mutation_p.I974M|EML5_ENST00000380664.5_Missense_Mutation_p.I1012M	NM_183387.2	NP_899243.1	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like 5	1012						cytoplasm|microtubule				breast(1)|endometrium(3)|kidney(4)|large_intestine(17)|lung(14)|ovary(3)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						CAGTAGCACAGATGGGCAGAT	0.418000													27	51					0	0	1	0	0
PKD2L1	9033	broad.mit.edu	37	10	102051057	102051057	+	Splice_Site	SNP	C	C	A			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr10:102051057C>A	ENST00000318222.3	-	12	2390		c.e12+1		PKD2L1_ENST00000353274.3_Splice_Site|PKD2L1_ENST00000338519.3_Splice_Site	NM_001253837.1|NM_016112.2	NP_001240766.1|NP_057196.2	Q9P0L9	PK2L1_HUMAN	polycystic kidney disease 2-like 1						signal transduction	integral to membrane	calcium activated cation channel activity|calcium ion binding|cytoskeletal protein binding			NS(2)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(4)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	43		Colorectal(252;0.117)		Epithelial(162;6.15e-10)|all cancers(201;5.14e-08)		GCCCAGCTCACCCTCTCTTCC	0.512000													55	68					1.11015e-26	1.29517e-26	1	1	0
TLX1	3195	broad.mit.edu	37	10	102896476	102896476	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr10:102896476G>A	ENST00000370196.6	+	3	2841	c.799G>A	c.(799-801)Gag>Aag	p.E267K	TLX1_ENST00000467928.2_3'UTR|RP11-31L23.3_ENST00000411459.1_RNA			P31314	TLX1_HUMAN	T-cell leukemia homeobox 1	267						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|upper_aerodigestive_tract(1)	2				Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		ACGGGAGGCCGAGAGGCAGCA	0.667000			T	"""TRB@, TRD@"""	T-ALL								62	79					0	0	1	0	0
AMY1C	278	broad.mit.edu	37	1	104297226	104297226	+	Silent	SNP	T	T	A			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr1:104297226T>A	ENST00000370079.3	+	6	1048	c.984T>A	c.(982-984)ctT>ctA	p.L328L		NM_001008219.1	NP_001008220.1	P04745	AMY1_HUMAN	amylase, alpha 1C (salivary)	328					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding|protein binding			lung(5)|skin(3)	8		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0654)|all cancers(265;0.0808)|Epithelial(280;0.0921)|Lung(183;0.111)		CCTCTATACTTACCTTCTGGG	0.403000													74	562					0	0	1	0	0
CTD-2066L21.3	0	broad.mit.edu	37	5	33162771	33162771	+	RNA	SNP	T	T	A			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr5:33162771T>A	ENST00000510327.1	-	0	346																											AGCAGTCTCCTGGAAGAGCAG	0.453000													6	23					0	0	1	0	0
COPZ1	22818	broad.mit.edu	37	12	54734300	54734300	+	Silent	SNP	C	C	T			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr12:54734300C>T	ENST00000549043.1	+	2	107	c.12C>T	c.(10-12)ttC>ttT	p.F4F	COPZ1_ENST00000552362.1_Intron|RP11-968A15.8_ENST00000553061.1_RNA|COPZ1_ENST00000262061.2_Intron|COPZ1_ENST00000548753.1_Intron|COPZ1_ENST00000416254.2_Intron|COPZ1_ENST00000552218.1_Intron|COPZ1_ENST00000551779.1_Intron|COPZ1_ENST00000548281.1_Intron|COPZ1_ENST00000455864.2_Intron|COPZ1_ENST00000549116.1_Intron|COPZ1_ENST00000553231.1_Intron			P61923	COPZ1_HUMAN	coatomer protein complex, subunit zeta 1	0					COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol				kidney(1)|lung(4)	5						TGGGAGGCTTCAGGACTGAAG	0.493000													31	94					0	0	1	0	0
CAMTA2	23125	broad.mit.edu	37	17	4875813	4875813	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr17:4875813G>A	ENST00000361571.5	-	15	2930	c.2519C>T	c.(2518-2520)tCg>tTg	p.S840L	CAMTA2_ENST00000381311.5_Missense_Mutation_p.S843L|CAMTA2_ENST00000572543.1_Missense_Mutation_p.S846L|CAMTA2_ENST00000358183.4_Missense_Mutation_p.S841L|CAMTA2_ENST00000348066.3_Missense_Mutation_p.S841L|CAMTA2_ENST00000414043.3_Missense_Mutation_p.S864L	NM_001171168.1	NP_001164639.1	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	841					cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(5)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	31						CTCCGAGGGCGAGGAGACGCT	0.637000													10	38					0	0	1	0	0
MRVI1	10335	broad.mit.edu	37	11	10622526	10622526	+	Silent	SNP	C	C	T			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr11:10622526C>T	ENST00000547195.1	-	14	2183	c.1683G>A	c.(1681-1683)gcG>gcA	p.A561A	MRVI1_ENST00000423302.2_Silent_p.A652A|MRVI1_ENST00000436272.1_Silent_p.A625A|MRVI1_ENST00000545852.1_Silent_p.A337A|MRVI1_ENST00000421747.1_Silent_p.A643A|LYVE1_ENST00000531706.1_Intron|MRVI1_ENST00000558540.1_Silent_p.A337A|MRVI1_ENST00000541483.1_Silent_p.A446A|MRVI1_ENST00000534266.2_Silent_p.A337A|MRVI1_ENST00000424001.1_Silent_p.A337A|MRVI1_ENST00000531107.1_Silent_p.A644A|MRVI1_ENST00000527509.2_Silent_p.A561A|MRVI1_ENST00000552103.1_Silent_p.A561A	NM_001100163.2|NM_001206881.1	NP_001093633.1|NP_001193810.1	Q9Y6F6	MRVI1_HUMAN	murine retrovirus integration site 1 homolog	625					platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(2)	22				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		CCATGAGCTCCGCATGGTCCT	0.522000													103	12					0	0	1	0	0
GRASP	160622	broad.mit.edu	37	12	52408572	52408572	+	Silent	SNP	C	C	T			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr12:52408572C>T	ENST00000293662.4	+	8	857	c.777C>T	c.(775-777)ttC>ttT	p.F259F	GRASP_ENST00000380039.2_Silent_p.F116F|GRASP_ENST00000552049.1_Silent_p.F116F|GRASP_ENST00000552963.1_3'UTR	NM_181711.2	NP_859062.1	Q7Z6J2	GRASP_HUMAN	GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein	259						cell junction|perinuclear region of cytoplasm|postsynaptic membrane				central_nervous_system(1)|large_intestine(1)|lung(1)|skin(2)	5				BRCA - Breast invasive adenocarcinoma(357;0.0967)		CGCTGCCCTTCGGGCCTCTGC	0.741000													6	24					0	0	1	0	0
DYNLT1	6993	broad.mit.edu	37	6	159057860	159057860	+	Nonstop_Mutation	SNP	C	C	G			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr6:159057860C>G	ENST00000367089.3	-	5	371	c.341G>C	c.(340-342)tGa>tCa	p.*114S	DYNLT1_ENST00000367088.1_3'UTR	NM_006519.2	NP_006510.1	P63172	DYLT1_HUMAN	dynein, light chain, Tctex-type 1	0					cell division|establishment of mitotic spindle orientation|intracellular transport of viral proteins in host cell|mitosis|negative regulation of neurogenesis|regulation of G-protein coupled receptor protein signaling pathway	cytoplasmic dynein complex|Golgi apparatus|microtubule|spindle	identical protein binding|motor activity			lung(2)	2		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;4.02e-18)|BRCA - Breast invasive adenocarcinoma(81;9.53e-06)		GACTGCAGGTCAAATAGACAG	0.488000													5	11					0	0	1	0	0
ITSN1	6453	broad.mit.edu	37	21	35122567	35122567	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr21:35122567C>T	ENST00000381318.3	+	6	754	c.466C>T	c.(466-468)Ccc>Tcc	p.P156S	ITSN1_ENST00000399326.3_Missense_Mutation_p.P156S|ITSN1_ENST00000399338.4_Missense_Mutation_p.P156S|ITSN1_ENST00000399367.3_Missense_Mutation_p.P156S|ITSN1_ENST00000381291.4_Missense_Mutation_p.P156S|AP000304.12_ENST00000429238.1_Intron|ITSN1_ENST00000399349.1_Missense_Mutation_p.P156S|ITSN1_ENST00000381285.4_Missense_Mutation_p.P156S|ITSN1_ENST00000437442.2_Missense_Mutation_p.P156S|ITSN1_ENST00000399355.2_Missense_Mutation_p.P156S|ITSN1_ENST00000399353.1_Missense_Mutation_p.P119S|ITSN1_ENST00000399352.1_Missense_Mutation_p.P156S|ITSN1_ENST00000379960.5_Missense_Mutation_p.P156S	NM_003024.2	NP_003015.2	Q15811	ITSN1_HUMAN	intersectin 1 (SH3 domain protein)	156					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(16)|lung(26)|ovary(4)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	67						AGCAGCTGTGCCCCCCCTGGC	0.522000													4	96					0	0	1	0	0
UACA	55075	broad.mit.edu	37	15	70960066	70960066	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr15:70960066G>A	ENST00000322954.6	-	16	3142	c.2957C>T	c.(2956-2958)gCc>gTc	p.A986V	UACA_ENST00000379983.2_Missense_Mutation_p.A973V|UACA_ENST00000539319.1_Missense_Mutation_p.A877V|UACA_ENST00000560441.1_Missense_Mutation_p.A971V	NM_018003.2	NP_060473.2	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and ankyrin repeats	986						cytoskeleton|extracellular region				breast(2)|endometrium(7)|kidney(4)|large_intestine(13)|lung(17)|ovary(2)|pancreas(1)|prostate(2)|skin(2)	50						GACAATTGGGGCGTATTTTAC	0.403000													4	123					0	0	1	0	0
NRP1	8829	broad.mit.edu	37	10	33469144	33469144	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr10:33469144C>T	ENST00000265371.4	-	18	3157	c.2632G>A	c.(2632-2634)Gtg>Atg	p.V878M	NRP1_ENST00000374867.2_Missense_Mutation_p.V878M|NRP1_ENST00000395995.1_Missense_Mutation_p.V861M|NRP1_ENST00000374875.1_Missense_Mutation_p.V690M			O14786	NRP1_HUMAN	neuropilin 1	878					axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	48					Palifermin(DB00039)|Pegaptanib(DB04895)	CAGTACAGCACGACCCCACAG	0.507000													92	76					0	0	1	0	0
AGRN	375790	broad.mit.edu	37	1	976686	976686	+	Silent	SNP	C	C	T			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr1:976686C>T	ENST00000379370.2	+	5	911	c.861C>T	c.(859-861)agC>agT	p.S287S		NM_198576.3	NP_940978.2	O00468	AGRIN_HUMAN	agrin	287	Kazal-like 2.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(2)|lung(20)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	42	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		TCTGCGGCAGCGACGGCGCCG	0.741000													4	4					0	0	1	0	0
CMPK2	129607	broad.mit.edu	37	2	6990106	6990106	+	Splice_Site	SNP	T	T	A			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr2:6990106T>A	ENST00000256722.5	-	5	1226		c.e5-2		CMPK2_ENST00000458098.1_Intron|CMPK2_ENST00000478738.1_Splice_Site	NM_207315.3	NP_997198.2	Q5EBM0	CMPK2_HUMAN	cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial						dTDP biosynthetic process	mitochondrion	ATP binding|cytidylate kinase activity|thymidylate kinase activity|UMP kinase activity			large_intestine(1)|lung(13)|prostate(1)|upper_aerodigestive_tract(1)	16	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					ATTTCTACCCTGGGGACAGGC	0.453000													27	46					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48450120	48450120	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr7:48450120G>A	ENST00000435803.1	+	40	12098	c.12074G>A	c.(12073-12075)cGt>cAt	p.R4025H		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	4025	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity	p.R4025H(1)|p.R3970H(1)		breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						GACCCAGGTCGTACGATCATC	0.602000													62	75					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52395199	52395199	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr3:52395199G>A	ENST00000420323.2	+	29	4966	c.4705G>A	c.(4705-4707)Gga>Aga	p.G1569R		NM_015512.4	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	1569	AAA 1 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GACACTGACCGGAGCTCTGCA	0.612000													21	21					0	0	1	0	0
APBA2	321	broad.mit.edu	37	15	29409304	29409304	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr15:29409304C>T	ENST00000558402.1	+	16	2817	c.2218C>T	c.(2218-2220)Ctc>Ttc	p.L740F	APBA2_ENST00000561069.1_Missense_Mutation_p.L740F|APBA2_ENST00000558330.1_Missense_Mutation_p.L728F|APBA2_ENST00000558259.1_Missense_Mutation_p.L740F|APBA2_ENST00000411764.1_Missense_Mutation_p.L728F			Q99767	APBA2_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 2	740					nervous system development|protein transport		protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|liver(2)|lung(33)|stomach(1)|urinary_tract(1)	59		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		GTTCAGGCTCCTCACGGGTCA	0.682000													7	165					0	0	1	0	0
NLRP7	199713	broad.mit.edu	37	19	55450780	55450780	+	Silent	SNP	G	G	A			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr19:55450780G>A	ENST00000446217.1	-	6	1893	c.1491C>T	c.(1489-1491)ctC>ctT	p.L497L	NLRP7_ENST00000340844.2_Silent_p.L469L|NLRP7_ENST00000590030.1_Silent_p.L469L|NLRP7_ENST00000328092.5_Silent_p.L469L|NLRP7_ENST00000588756.1_Silent_p.L469L|NLRP7_ENST00000448121.2_Silent_p.L469L|NLRP7_ENST00000592784.1_Silent_p.L469L			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	469							ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		GCTGGAAGCTGAGGTGGATGA	0.617000													34	71					0	0	1	0	0
SMG8	55181	broad.mit.edu	37	17	57290593	57290593	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr17:57290593G>C	ENST00000543872.2	+	4	2673	c.2409G>C	c.(2407-2409)agG>agC	p.R803S	CTD-2510F5.6_ENST00000577660.1_Intron|SMG8_ENST00000300917.5_Missense_Mutation_p.R803S			Q8ND04	SMG8_HUMAN	SMG8 nonsense mediated mRNA decay factor	803					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of protein kinase activity		protein binding			NS(1)|breast(5)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(1)	33						TTGTCATCAGGACTAGAGCTG	0.428000													75	85					0	0	1	0	0
ZNF554	115196	broad.mit.edu	37	19	2832379	2832379	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr19:2832379G>A	ENST00000317243.5	+	4	530	c.332G>A	c.(331-333)aGt>aAt	p.S111N	ZNF554_ENST00000591265.1_Missense_Mutation_p.S111N	NM_001102651.1	NP_001096121.1	Q86TJ5	ZN554_HUMAN	zinc finger protein 554	111	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|liver(3)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	23		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CAAGTCACTAGTCTTTCCTCA	0.448000													87	89					0	0	1	0	0
UBC	7316	broad.mit.edu	37	12	125398009	125398009	+	Splice_Site	SNP	T	T	C			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr12:125398009T>C	ENST00000546120.1	-	2	375	c.309A>G	c.(307-309)aaA>aaG	p.K103K	UBC_ENST00000339647.5_Silent_p.K103K|UBC_ENST00000536769.1_Silent_p.K103K|UBC_ENST00000538617.1_Silent_p.K103K			P0CG48	UBC_HUMAN	ubiquitin C	179	Ubiquitin-like 2.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			breast(3)|endometrium(4)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		GGATCTTTGCTTTGACGTTCT	0.537000													4	116					0	0	1	0	0
ALG10B	144245	broad.mit.edu	37	12	38714110	38714110	+	Missense_Mutation	SNP	A	A	G			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr12:38714110A>G	ENST00000308742.4	+	3	833	c.517A>G	c.(517-519)Aaa>Gaa	p.K173E	ALG10B_ENST00000551464.1_Intron	NM_001013620.3	NP_001013642.1	Q5I7T1	AG10B_HUMAN	ALG10B, alpha-1,2-glucosyltransferase	173					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|plasma membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			breast(2)|kidney(3)|large_intestine(7)|lung(8)|ovary(4)|skin(1)	25	Esophageal squamous(101;0.187)	Lung NSC(34;0.204)|all_lung(34;0.235)				TGGAAATCATAAAACTTCAGC	0.338000													79	75					0	0	1	0	0
ATAD2	29028	broad.mit.edu	37	8	124348766	124348766	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr8:124348766C>G	ENST00000287394.5	-	22	3165	c.3058G>C	c.(3058-3060)Gat>Cat	p.D1020H	ATAD2_ENST00000521903.1_Missense_Mutation_p.D338H	NM_014109.3	NP_054828.2	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	1020	Bromo.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|lung(16)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	48	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			GTGACATAATCAGGAACCTAA	0.328000													27	112					0	0	1	0	0
FAM118B	79607	broad.mit.edu	37	11	126120474	126120474	+	Missense_Mutation	SNP	T	T	G			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr11:126120474T>G	ENST00000533050.1	+	5	906	c.413T>G	c.(412-414)aTg>aGg	p.M138R	FAM118B_ENST00000360194.4_Missense_Mutation_p.M138R|FAM118B_ENST00000529731.1_Intron|FAM118B_ENST00000525728.1_3'UTR	NM_024556.3	NP_078832.1	Q9BPY3	F118B_HUMAN	family with sequence similarity 118, member B	138										breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|skin(1)	13	all_hematologic(175;0.145)	Breast(109;0.00156)|Lung NSC(97;0.00948)|all_lung(97;0.0101)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0784)		GAGTCAAAGATGGAAGATTCT	0.368000													29	45					0	0	1	0	0
KBTBD11	9920	broad.mit.edu	37	8	1950115	1950115	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr8:1950115G>A	ENST00000320248.3	+	2	1723	c.757G>A	c.(757-759)Gac>Aac	p.D253N		NM_014867.2	NP_055682.1	O94819	KBTBB_HUMAN	kelch repeat and BTB (POZ) domain containing 11	253										lung(1)|pancreas(1)	2		Ovarian(12;0.0563)|Colorectal(14;0.0815)|Hepatocellular(245;0.0831)		BRCA - Breast invasive adenocarcinoma(11;7.72e-05)|READ - Rectum adenocarcinoma(644;0.0929)|COAD - Colon adenocarcinoma(149;0.134)		CGAGCTGCGCGACGCCGCCTA	0.726000													4	7					0	0	1	0	0
IL6ST	3572	broad.mit.edu	37	5	55248168	55248168	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr5:55248168C>T	ENST00000381298.2	-	12	1774	c.1462G>A	c.(1462-1464)Gag>Aag	p.E488K	IL6ST_ENST00000502326.3_Missense_Mutation_p.E488K|IL6ST_ENST00000381293.2_Intron|IL6ST_ENST00000336909.5_Missense_Mutation_p.E488K|IL6ST_ENST00000536319.1_3'UTR|IL6ST_ENST00000381287.4_3'UTR|IL6ST_ENST00000381294.3_Missense_Mutation_p.E427K|IL6ST_ENST00000381286.3_Intron|IL6ST_ENST00000522633.2_3'UTR	NM_001190981.1|NM_002184.3|NM_175767.2	NP_001177910.1|NP_002175.2|NP_786943.1	P40189	IL6RB_HUMAN	interleukin 6 signal transducer (gp130, oncostatin M receptor)	488	Fibronectin type-III 4.				interleukin-6-mediated signaling pathway|leukemia inhibitory factor signaling pathway|negative regulation of interleukin-6-mediated signaling pathway|positive regulation of anti-apoptosis|positive regulation of cardiac muscle hypertrophy|positive regulation of osteoblast differentiation|positive regulation of T cell proliferation|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation vascular endothelial growth factor production	ciliary neurotrophic factor receptor complex|extracellular region|extracellular space|interleukin-6 receptor complex|oncostatin-M receptor complex	ciliary neurotrophic factor receptor activity|ciliary neurotrophic factor receptor binding|growth factor binding|protein homodimerization activity			breast(2)|endometrium(5)|kidney(5)|large_intestine(4)|liver(2)|lung(1)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	26		Lung NSC(810;8.69e-05)|Prostate(74;0.00308)|Breast(144;0.0544)|Ovarian(174;0.223)				CATTTGCTCTCTGCTAAGTTC	0.343000			O		hepatocellular ca								26	32					0	0	1	0	0
TMTC2	160335	broad.mit.edu	37	12	83359462	83359462	+	Missense_Mutation	SNP	G	G	T			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr12:83359462G>T	ENST00000549919.1	+	7	3595	c.1790G>T	c.(1789-1791)aGc>aTc	p.S597I	TMTC2_ENST00000548305.1_Missense_Mutation_p.S603I|TMTC2_ENST00000321196.3_Missense_Mutation_p.S603I			Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat containing 2	603						endoplasmic reticulum|integral to membrane	binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(7)|lung(13)|ovary(2)|skin(1)|urinary_tract(1)	39						GCACACAAGAGCTCTGTTACC	0.483000													30	10					3.1745e-13	3.60348e-13	1	1	0
MDM1	56890	broad.mit.edu	37	12	68690759	68690759	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr12:68690759C>G	ENST00000303145.7	-	13	2062	c.1976G>C	c.(1975-1977)gGa>gCa	p.G659A	MDM1_ENST00000411698.2_Missense_Mutation_p.G624A|MDM1_ENST00000540418.1_Missense_Mutation_p.G379A	NM_017440.4	NP_059136.2	Q8TC05	MDM1_HUMAN	Mdm1 nuclear protein homolog (mouse)	659						nucleus				breast(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|prostate(2)|skin(7)	33			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000174)		CCTTGCTTTTCCCACTTAAAA	0.323000													12	343					0	0	1	0	0
KRT2	3849	broad.mit.edu	37	12	53039072	53039072	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr12:53039072C>T	ENST00000309680.3	-	9	1672	c.1651G>A	c.(1651-1653)Ggt>Agt	p.G551S		NM_000423.2	NP_000414.2	P35908	K22E_HUMAN	keratin 2	551	Tail.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(18)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32				BRCA - Breast invasive adenocarcinoma(357;0.19)		CCTCCACTACCGCCTCTGGAG	0.577000													149	425					0	0	1	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54905744	54905744	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr12:54905744C>G	ENST00000293373.6	+	9	875	c.796C>G	c.(796-798)Ctt>Gtt	p.L266V	NCKAP1L_ENST00000545638.2_Missense_Mutation_p.L216V|NCKAP1L_ENST00000552211.1_3'UTR	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	266					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						TGGGTTTCTTCTTTGTCATGG	0.478000													41	179					0	0	1	0	0
CATSPERD	257062	broad.mit.edu	37	19	5778498	5778498	+	Silent	SNP	C	C	T			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr19:5778498C>T	ENST00000381624.3	+	22	2269	c.2208C>T	c.(2206-2208)tcC>tcT	p.S736S	CATSPERD_ENST00000309164.7_3'UTR	NM_152784.3	NP_689997.3	Q86XM0	TM146_HUMAN	catsper channel auxiliary subunit delta	736						integral to membrane											TCCTGGGGTCCGTTTGGCTGG	0.567000													47	37					0	0	1	0	0
MRGPRF	116535	broad.mit.edu	37	11	68773019	68773019	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr11:68773019G>C	ENST00000309099.6	-	3	1141	c.759C>G	c.(757-759)atC>atG	p.I253M	MRGPRF_ENST00000441623.1_Missense_Mutation_p.I253M	NM_145015.4	NP_659452.3	Q96AM1	MRGRF_HUMAN	MAS-related GPR, member F	253						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(3)|lung(4)	7			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			TCCCTAAGTAGATGGAGGACA	0.617000													6	4					0	0	1	0	0
TRPC7	57113	broad.mit.edu	37	5	135587397	135587397	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr5:135587397C>T	ENST00000513104.1	-	6	1801	c.1519G>A	c.(1519-1521)Gtg>Atg	p.V507M	TRPC7_ENST00000426057.2_Missense_Mutation_p.V391M|TRPC7_ENST00000355180.3_Missense_Mutation_p.V446M	NM_020389.2	NP_065122.1	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel, subfamily C, member 7	507					axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(3)	46			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TCGTCCTGCACGTGCTGGTCC	0.582000													18	18					0	0	1	0	0
IQCH	64799	broad.mit.edu	37	15	67571810	67571810	+	Missense_Mutation	SNP	G	G	T			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr15:67571810G>T	ENST00000335894.4	+	4	413	c.347G>T	c.(346-348)aGa>aTa	p.R116I	IQCH_ENST00000358767.3_5'UTR|IQCH_ENST00000546225.1_5'UTR|IQCH_ENST00000512104.1_Missense_Mutation_p.R116I	NM_001031715.2	NP_001026885	Q86VS3	IQCH_HUMAN	IQ motif containing H	116										NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(2)|pancreas(2)|skin(5)|upper_aerodigestive_tract(1)	33				Colorectal(3;0.0856)		CAACCCCAAAGACAGCACAGT	0.403000													23	54					3.01185e-09	3.32889e-09	1	1	0
PNLIPRP1	5407	broad.mit.edu	37	10	118350685	118350685	+	Missense_Mutation	SNP	C	C	A			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr10:118350685C>A	ENST00000528052.1	+	2	115	c.44C>A	c.(43-45)gCc>gAc	p.A15D	PNLIPRP1_ENST00000480870.2_3'UTR|PNLIPRP1_ENST00000534537.1_Missense_Mutation_p.A15D|PNLIPRP1_ENST00000358834.4_Missense_Mutation_p.A15D|PNLIPRP1_ENST00000442761.1_Missense_Mutation_p.A15D			P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1	15					lipid metabolic process		calcium ion binding|triglyceride lipase activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	38				all cancers(201;0.0161)		CTGGGAGCAGCCAAAGGTAAG	0.498000													7	18					0.00621372	0.00647048	1	1	0
IRX1	79192	broad.mit.edu	37	5	3600193	3600193	+	Silent	SNP	C	C	T			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr5:3600193C>T	ENST00000302006.3	+	2	1183	c.1131C>T	c.(1129-1131)agC>agT	p.S377S	CTD-2012M11.3_ENST00000559410.1_RNA	NM_024337.3	NP_077313.3	P78414	IRX1_HUMAN	iroquois homeobox 1	377						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|endometrium(5)|kidney(2)|large_intestine(5)|lung(18)|ovary(2)|pancreas(1)|prostate(5)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	43						GGACCAACAGCGCATTCCTCG	0.682000													18	57					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178916836	178916836	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr3:178916836C>G	ENST00000263967.3	+	2	380	c.223C>G	c.(223-225)Caa>Gaa	p.Q75E		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	75	PI3K-ABD.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.Q75E(1)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AAGTGTTACTCAAGAAGCAGA	0.348000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			49	104					0	0	1	0	0
ERBB2	2064	broad.mit.edu	37	17	37879658	37879658	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr17:37879658G>A	ENST00000406381.2	+	19	2453	c.1943G>A	c.(1942-1944)cGg>cAg	p.R648Q	ERBB2_ENST00000540147.1_Missense_Mutation_p.R648Q|ERBB2_ENST00000445658.2_Missense_Mutation_p.R402Q|ERBB2_ENST00000584601.1_Missense_Mutation_p.R648Q|ERBB2_ENST00000584450.1_Missense_Mutation_p.R678Q|ERBB2_ENST00000269571.5_Missense_Mutation_p.R678Q|ERBB2_ENST00000541774.1_Missense_Mutation_p.R663Q	NM_001005862.1	NP_001005862.1	P04626	ERBB2_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	678					cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(1)|breast(16)|central_nervous_system(17)|endometrium(6)|haematopoietic_and_lymphoid_tissue(8)|kidney(4)|large_intestine(16)|liver(3)|lung(125)|ovary(18)|pancreas(1)|prostate(4)|skin(1)|stomach(14)|upper_aerodigestive_tract(9)|urinary_tract(4)	247	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	ATCAAGCGACGGCAGCAGAAG	0.637000		1	"""A, Mis, O"""		"""breast, ovarian, other tumour types, NSCLC, gastric"""					TCGA GBM(5;<1E-08)			52	74					0	0	1	0	0
FBXO21	23014	broad.mit.edu	37	12	117628125	117628125	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr12:117628125G>C	ENST00000427718.2	-	1	211	c.137C>G	c.(136-138)tCg>tGg	p.S46W	FBXO21_ENST00000330622.5_Missense_Mutation_p.S46W	NM_015002.2|NM_033624.2	NP_055817.1|NP_296373.1	O94952	FBX21_HUMAN	F-box protein 21	46	F-box.				ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			breast(4)|endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|pancreas(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	29	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0291)		GGCCGTCAGCGAGCCGCAGCA	0.716000													11	83					0	0	1	0	0
NDUFS7	374291	broad.mit.edu	37	19	1388566	1388566	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr19:1388566G>C	ENST00000313408.7	+	3	119	c.96G>C	c.(94-96)caG>caC	p.Q32H	NDUFS7_ENST00000233627.9_Missense_Mutation_p.Q32H|NDUFS7_ENST00000414651.2_Missense_Mutation_p.Q32H|NDUFS7_ENST00000540530.1_3'UTR|NDUFS7_ENST00000539480.1_Missense_Mutation_p.Q32H|NDUFS7_ENST00000546283.1_Missense_Mutation_p.Q32H			O75251	NDUS7_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)	32					mitochondrial electron transport, NADH to ubiquinone|mitochondrial respiratory chain complex I assembly|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|metal ion binding|NADH dehydrogenase (ubiquinone) activity|protein binding|quinone binding			ovary(1)	1		Acute lymphoblastic leukemia(61;5.61e-13)|all_hematologic(61;2.65e-08)|Breast(49;0.00186)|Lung NSC(49;0.00292)|all_lung(49;0.00419)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	NADH(DB00157)	GTGTCCATCAGAGCGTGGCCA	0.672000													15	26					0	0	1	0	0
CPSF4	10898	broad.mit.edu	37	7	99042455	99042455	+	Silent	SNP	C	C	T			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr7:99042455C>T	ENST00000436336.2	+	2	308	c.147C>T	c.(145-147)tgC>tgT	p.C49C	CPSF4_ENST00000292476.5_Silent_p.C49C|ATP5J2-PTCD1_ENST00000413834.1_Intron|PTCD1_ENST00000555673.1_Intron|CPSF4_ENST00000451876.1_Silent_p.C49C|CPSF4_ENST00000471455.1_3'UTR|ATP5J2-PTCD1_ENST00000437572.1_Intron|CPSF4_ENST00000441580.1_5'UTR	NM_001081559.1|NM_006693.2	NP_001075028.1|NP_006684.1	O95639	CPSF4_HUMAN	cleavage and polyadenylation specific factor 4, 30kDa	49					modification by virus of host mRNA processing|mRNA processing|viral infectious cycle	mRNA cleavage and polyadenylation specificity factor complex	RNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(5)|lung(5)	14	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					AAGCTGCCTGCGGCAAAGGTA	0.547000													108	111					0	0	1	0	0
RSC1A1	6248	broad.mit.edu	37	1	15986664	15986664	+	Missense_Mutation	SNP	T	T	C			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr1:15986664T>C	ENST00000345034.1	+	1	301	c.301T>C	c.(301-303)Tcc>Ccc	p.S101P	DDI2_ENST00000480945.1_3'UTR	NM_006511.1	NP_006502.1	Q92681	RSCA1_HUMAN	regulatory solute carrier protein, family 1, member 1	101					negative regulation of transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transport	cell junction|Golgi apparatus|nucleus	ion channel inhibitor activity			kidney(1)|large_intestine(3)|lung(6)|ovary(1)	11		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00276)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.73e-07)|COAD - Colon adenocarcinoma(227;3.49e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000114)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GCAGAATTCATCCGAAGAAAT	0.423000													5	163					0	0	1	0	0
ARMC2	84071	broad.mit.edu	37	6	109282854	109282854	+	Silent	SNP	G	G	C			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr6:109282854G>C	ENST00000392644.4	+	14	2163	c.1995G>C	c.(1993-1995)gtG>gtC	p.V665V	ARMC2_ENST00000368972.3_Silent_p.V500V|ARMC2_ENST00000481850.1_3'UTR	NM_032131.4	NP_115507.4	Q8NEN0	ARMC2_HUMAN	armadillo repeat containing 2	665							binding			endometrium(3)|large_intestine(8)|lung(10)|ovary(1)|prostate(1)|skin(1)	24		all_cancers(87;1.14e-07)|Acute lymphoblastic leukemia(125;2.3e-10)|all_hematologic(75;3.3e-08)|all_epithelial(87;0.000111)|Colorectal(196;0.03)|all_lung(197;0.11)		Epithelial(106;0.000197)|BRCA - Breast invasive adenocarcinoma(108;0.000236)|all cancers(137;0.000279)|OV - Ovarian serous cystadenocarcinoma(136;0.00434)		ACTACCAAGTGAAGAATTCCA	0.338000													37	50					0	0	1	0	0
MYBPHL	343263	broad.mit.edu	37	1	109840170	109840170	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr1:109840170G>A	ENST00000357155.1	-	3	353	c.304C>T	c.(304-306)Cgg>Tgg	p.R102W	MYBPHL_ENST00000477962.1_Intron	NM_001010985.2|NM_001265613.1	NP_001010985.2|NP_001252542.1	A2RUH7	MBPHL_HUMAN	myosin binding protein H-like	102	Ig-like C2-type 1.									central_nervous_system(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(2)	14		all_lung(203;0.00519)|all_epithelial(167;0.00575)|Lung NSC(277;0.00822)		Colorectal(144;0.0306)|Lung(183;0.0681)|COAD - Colon adenocarcinoma(174;0.117)|Epithelial(280;0.197)|all cancers(265;0.225)		TCCCCATTCCGCACACTCACA	0.592000													4	97					0	0	1	0	0
C9	735	broad.mit.edu	37	5	39306848	39306848	+	Silent	SNP	T	T	G			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr5:39306848T>G	ENST00000263408.4	-	9	1382	c.1287A>C	c.(1285-1287)atA>atC	p.I429I		NM_001737.3	NP_001728.1	P02748	CO9_HUMAN	complement component 9	429	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex				central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	32	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			TTCCACCTCTTATGAGTGAAA	0.398000													26	88					0	0	1	0	0
TNFAIP3	7128	broad.mit.edu	37	6	138199923	138199923	+	Silent	SNP	G	G	A			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr6:138199923G>A	ENST00000237289.4	+	7	1407	c.1341G>A	c.(1339-1341)gcG>gcA	p.A447A		NM_001270507.1|NM_001270508.1|NM_006290.3	NP_001257436.1|NP_001257437.1|NP_006281.1	P21580	TNAP3_HUMAN	tumor necrosis factor, alpha-induced protein 3	447	Interaction with NAF1 (By similarity).				anti-apoptosis|apoptosis|B-1 B cell homeostasis|negative regulation of B cell activation|negative regulation of bone resorption|negative regulation of CD40 signaling pathway|negative regulation of endothelial cell apoptosis|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of interleukin-2 production|negative regulation of interleukin-6 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of osteoclast proliferation|negative regulation of protein ubiquitination|negative regulation of smooth muscle cell proliferation|negative regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 3 signaling pathway|negative regulation of tumor necrosis factor production|negative regulation of type I interferon production|positive regulation of protein catabolic process|protein K48-linked ubiquitination|protein K63-linked deubiquitination|protein oligomerization|regulation of defense response to virus by host|regulation of germinal center formation|regulation of vascular wound healing|tolerance induction to lipopolysaccharide	centrosome|cytosol|nucleus	caspase inhibitor activity|DNA binding|protease binding|protein self-association|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-protein ligase activity|ubiquitin-specific protease activity|zinc ion binding	p.0?(25)|p.A447A(1)		breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(196)|kidney(1)|large_intestine(4)|lung(13)|ovary(4)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	225	Breast(32;0.135)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000849)|OV - Ovarian serous cystadenocarcinoma(155;0.00468)		AGCCCTTGGCGTGGAACCCTG	0.627000			"""D, N, F"""		"""marginal zone B-cell lymphomas, Hodgkin's lymphoma, primary mediastinal B cell lymphoma"""								31	42					0	0	1	0	0
MFSD12	126321	broad.mit.edu	37	19	3547922	3547922	+	Missense_Mutation	SNP	G	G	T			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr19:3547922G>T	ENST00000355415.2	-	4	930	c.761C>A	c.(760-762)aCc>aAc	p.T254N	MFSD12_ENST00000389395.3_Missense_Mutation_p.T254N|AC005786.7_ENST00000589360.1_RNA|MFSD12_ENST00000398558.4_Missense_Mutation_p.T254N|MFSD12_ENST00000591878.1_5'UTR	NM_174983.3	NP_778148.2	Q6NUT3	CS028_HUMAN	major facilitator superfamily domain containing 12	254					transmembrane transport	integral to membrane				cervix(1)|endometrium(2)|lung(4)|urinary_tract(2)	9						CAACAGGGGGGTGTGCTCGCC	0.711000													12	15					2.27111e-07	2.44581e-07	1	1	0
UTP14A	10813	broad.mit.edu	37	X	129045885	129045885	+	Silent	SNP	C	C	G			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chrX:129045885C>G	ENST00000394422.3	+	6	553	c.525C>G	c.(523-525)ctC>ctG	p.L175L	RP4-537K23.4_ENST00000432062.1_RNA|UTP14A_ENST00000425117.2_Intron|UTP14A_ENST00000371051.5_Silent_p.L121L	NM_006649.3	NP_006640.2	Q9BVJ6	UT14A_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)	175					rRNA processing	nucleolus|small-subunit processome	protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|liver(2)|lung(16)|ovary(3)|urinary_tract(1)	32						AACATGTGCTCAGTGGCTGGA	0.473000													36	7					0	0	1	0	0
MTHFD1L	25902	broad.mit.edu	37	6	151334925	151334925	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr6:151334925G>A	ENST00000367321.3	+	22	2550	c.2276G>A	c.(2275-2277)gGt>gAt	p.G759D		NM_001242767.1|NM_001242768.1|NM_015440.4	NP_001229696.1|NP_001229697.1|NP_056255.2	Q6UB35	C1TM_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like	759	Formyltetrahydrofolate synthetase.				folic acid-containing compound biosynthetic process|formate metabolic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|protein homodimerization activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(12)|lung(8)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)	29		Ovarian(120;0.128)		OV - Ovarian serous cystadenocarcinoma(155;8.7e-12)		GTAACGGCTGGTGTTCCTCTT	0.363000													5	10					0	0	1	0	0
PNLIPRP1	5407	broad.mit.edu	37	10	118350686	118350686	+	Silent	SNP	C	C	A			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr10:118350686C>A	ENST00000528052.1	+	2	116	c.45C>A	c.(43-45)gcC>gcA	p.A15A	PNLIPRP1_ENST00000480870.2_3'UTR|PNLIPRP1_ENST00000534537.1_Silent_p.A15A|PNLIPRP1_ENST00000358834.4_Silent_p.A15A|PNLIPRP1_ENST00000442761.1_Silent_p.A15A			P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1	15					lipid metabolic process		calcium ion binding|triglyceride lipase activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	38				all cancers(201;0.0161)		TGGGAGCAGCCAAAGGTAAGA	0.498000													7	18					0.00621372	0.00647048	1	1	0
ACSL1	2180	broad.mit.edu	37	4	185684403	185684403	+	Missense_Mutation	SNP	A	A	G			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr4:185684403A>G	ENST00000515030.1	-	16	1764	c.1439T>C	c.(1438-1440)gTt>gCt	p.V480A	ACSL1_ENST00000437665.3_Missense_Mutation_p.V309A|ACSL1_ENST00000454703.2_Missense_Mutation_p.V309A|ACSL1_ENST00000507295.1_Missense_Mutation_p.V446A|ACSL1_ENST00000513317.1_Missense_Mutation_p.V480A|ACSL1_ENST00000281455.2_Missense_Mutation_p.V480A|ACSL1_ENST00000504342.1_Missense_Mutation_p.V480A			P33121	ACSL1_HUMAN	acyl-CoA synthetase long-chain family member 1	480					digestion|fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|regulation of fatty acid oxidation|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|liver(1)|lung(17)|ovary(2)|prostate(1)|skin(2)	38		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00172)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0315)|all_neural(102;0.107)|Medulloblastoma(177;0.146)		all cancers(43;1.33e-28)|Epithelial(43;5.3e-25)|OV - Ovarian serous cystadenocarcinoma(60;4.88e-11)|Colorectal(24;3.59e-06)|STAD - Stomach adenocarcinoma(60;2.72e-05)|GBM - Glioblastoma multiforme(59;2.83e-05)|BRCA - Breast invasive adenocarcinoma(30;7.66e-05)|COAD - Colon adenocarcinoma(29;0.000538)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.0419)	Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CGGGGCCCCAACATGGCCTGT	0.433000													11	17					0	0	1	0	0
ITGA2B	3674	broad.mit.edu	37	17	42455873	42455873	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr17:42455873C>T	ENST00000262407.5	-	20	1982	c.1951G>A	c.(1951-1953)Ggc>Agc	p.G651S	ITGA2B_ENST00000353281.4_Missense_Mutation_p.G651S	NM_000419.3	NP_000410.2	P08514	ITA2B_HUMAN	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	651					axon guidance|integrin-mediated signaling pathway|platelet activation|platelet degranulation	integrin complex|platelet alpha granule membrane	identical protein binding|receptor activity			biliary_tract(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(8)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.191)	Tirofiban(DB00775)	AGCGGGGAGCCCGTCCTGTGG	0.617000													19	20					0	0	1	0	0
ARHGAP39	80728	broad.mit.edu	37	8	145763117	145763117	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr8:145763117C>G	ENST00000377307.2	-	6	2686	c.2602G>C	c.(2602-2604)Gaa>Caa	p.E868Q	ARHGAP39_ENST00000540274.1_Intron|ARHGAP39_ENST00000276826.5_Intron	NM_025251.1	NP_079527.1	Q9C0H5	RHG39_HUMAN	Rho GTPase activating protein 39	840	MyTH4.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22						TCCGGCTCTTCAACATAAGGC	0.557000													48	209					0	0	1	0	0
CLIP2	7461	broad.mit.edu	37	7	73731974	73731974	+	Missense_Mutation	SNP	C	C	T	rs142367137		TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr7:73731974C>T	ENST00000223398.6	+	2	425	c.98C>T	c.(97-99)gCg>gTg	p.A33V	CLIP2_ENST00000361545.5_Missense_Mutation_p.A33V|CLIP2_ENST00000395060.1_Missense_Mutation_p.A33V	NM_003388.4	NP_003379	Q9UDT6	CLIP2_HUMAN	CAP-GLY domain containing linker protein 2	33						microtubule associated complex				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(13)|pancreas(1)|prostate(2)|skin(3)	30						TCCTCGGCGGCGGTGGCCGCT	0.657000													81	158					0	0	1	0	0
PATZ1	23598	broad.mit.edu	37	22	31737642	31737642	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr22:31737642G>A	ENST00000215919.3	-	3	1536	c.1363C>T	c.(1363-1365)Ccg>Tcg	p.P455S	PATZ1_ENST00000266269.5_Intron|PATZ1_ENST00000405309.3_Intron|PATZ1_ENST00000351933.4_Intron	NM_032051.1	NP_114440.1	Q9HBE1	PATZ1_HUMAN	POZ (BTB) and AT hook containing zinc finger 1	0					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/PATZ1(2)	NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(2)	12						TCCAGGGGCGGCAGGCCGCTG	0.642000													4	94					0	0	1	0	0
SLC24A1	9187	broad.mit.edu	37	15	65918060	65918060	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr15:65918060C>T	ENST00000261892.6	+	2	1929	c.1642C>T	c.(1642-1644)Cga>Tga	p.R548*	SLC24A1_ENST00000546330.1_Nonsense_Mutation_p.R548*|SLC24A1_ENST00000544319.2_Nonsense_Mutation_p.R548*|SLC24A1_ENST00000537259.1_Nonsense_Mutation_p.R548*|SLC24A1_ENST00000399033.4_Nonsense_Mutation_p.R548*|SLC24A1_ENST00000339868.6_Nonsense_Mutation_p.R548*	NM_001254740.1|NM_004727.2	NP_001241669.1|NP_004718.1	O60721	NCKX1_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 1	548					response to light intensity|visual perception	integral to plasma membrane|membrane fraction|outer membrane	calcium, potassium:sodium antiporter activity|protein binding|symporter activity			breast(2)|endometrium(7)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23						CCTCTTCTCCCGAGAGATCCT	0.502000													68	121					0	0	1	0	0
KBTBD11	9920	broad.mit.edu	37	8	1950616	1950616	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr8:1950616G>A	ENST00000320248.3	+	2	2224	c.1258G>A	c.(1258-1260)Gag>Aag	p.E420K		NM_014867.2	NP_055682.1	O94819	KBTBB_HUMAN	kelch repeat and BTB (POZ) domain containing 11	420										lung(1)|pancreas(1)	2		Ovarian(12;0.0563)|Colorectal(14;0.0815)|Hepatocellular(245;0.0831)		BRCA - Breast invasive adenocarcinoma(11;7.72e-05)|READ - Rectum adenocarcinoma(644;0.0929)|COAD - Colon adenocarcinoma(149;0.134)		CGTGGGCGGCGAGTGCCTGCT	0.786000													6	4					0	0	1	0	0
KIF12	113220	broad.mit.edu	37	9	116857341	116857341	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr9:116857341G>A	ENST00000374118.3	-	8	904	c.667C>T	c.(667-669)Cga>Tga	p.R223*	KIF12_ENST00000473174.1_5'UTR	NM_138424.1	NP_612433.1	Q96FN5	KIF12_HUMAN	kinesin family member 12	356	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	17						CGCTGAGCTCGGCTTGCATAT	0.652000													32	41					0	0	1	0	0
DIXDC1	85458	broad.mit.edu	37	11	111848509	111848509	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr11:111848509C>T	ENST00000315253.5	+	1	477	c.13C>T	c.(13-15)Caa>Taa	p.Q5*	DIXDC1_ENST00000389821.4_Intron|DIXDC1_ENST00000440460.2_Intron	NM_033425.3	NP_219493.1	Q155Q3	DIXC1_HUMAN	DIX domain containing 1	0					multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytosol|focal adhesion	actin binding|gamma-tubulin binding|signal transducer activity			cervix(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)	17		all_cancers(61;7.58e-15)|all_epithelial(67;5.42e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;2.99e-07)|BRCA - Breast invasive adenocarcinoma(274;6.72e-07)|all cancers(92;6.25e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0548)		GGGAGGGACGCAAGTCAAATG	0.632000													3	6					0	0	1	0	0
VGLL2	245806	broad.mit.edu	37	6	117591920	117591920	+	Silent	SNP	G	G	A			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr6:117591920G>A	ENST00000326274.5	+	3	796	c.606G>A	c.(604-606)gcG>gcA	p.A202A	VGLL2_ENST00000352536.3_Intron	NM_182645.3	NP_872586.1	Q8N8G2	VGLL2_HUMAN	vestigial like 2 (Drosophila)	202					transcription, DNA-dependent	nucleus				central_nervous_system(1)|kidney(1)|lung(3)	5				GBM - Glioblastoma multiforme(226;0.0254)|all cancers(137;0.0676)|OV - Ovarian serous cystadenocarcinoma(136;0.0757)		CGCACCACGCGCACCCGCATC	0.786000													10	8					0	0	1	0	0
KREMEN1	83999	broad.mit.edu	37	22	29533554	29533554	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr22:29533554G>A	ENST00000400338.2	+	6	909	c.856G>A	c.(856-858)Ggg>Agg	p.G286R	KREMEN1_ENST00000327813.5_Missense_Mutation_p.G286R|KREMEN1_ENST00000400335.4_Missense_Mutation_p.G286R|KREMEN1_ENST00000407188.1_Missense_Mutation_p.G284R			Q96MU8	KREM1_HUMAN	kringle containing transmembrane protein 1	284	CUB.				cell communication|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane|membrane fraction	protein binding	p.G286R(1)		breast(1)|endometrium(3)|large_intestine(2)|lung(8)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)	20						CCGCTTCCACGGGAGGAGCCG	0.552000													38	36					0	0	1	0	0
PLIN5	440503	broad.mit.edu	37	19	4523754	4523754	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr19:4523754G>A	ENST00000381848.3	-	8	1258	c.1178C>T	c.(1177-1179)gCg>gTg	p.A393V		NM_001013706.2	NP_001013728.2	Q00G26	PLIN5_HUMAN	perilipin 5	393						lipid particle				endometrium(4)|lung(3)|skin(2)|upper_aerodigestive_tract(1)	10						CACCAGGTCCGCCAGGTCGGG	0.736000													4	135					0	0	1	0	0
FAM118B	79607	broad.mit.edu	37	11	126120483	126120483	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr11:126120483C>G	ENST00000533050.1	+	5	915	c.422C>G	c.(421-423)tCt>tGt	p.S141C	FAM118B_ENST00000360194.4_Missense_Mutation_p.S141C|FAM118B_ENST00000529731.1_Intron|FAM118B_ENST00000525728.1_3'UTR	NM_024556.3	NP_078832.1	Q9BPY3	F118B_HUMAN	family with sequence similarity 118, member B	141										breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|skin(1)	13	all_hematologic(175;0.145)	Breast(109;0.00156)|Lung NSC(97;0.00948)|all_lung(97;0.0101)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0784)		ATGGAAGATTCTGGAAAACAG	0.388000													28	45					0	0	1	0	0
CBLN4	140689	broad.mit.edu	37	20	54579155	54579155	+	Missense_Mutation	SNP	C	C	A			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr20:54579155C>A	ENST00000064571.2	-	1	1373	c.73G>T	c.(73-75)Gtc>Ttc	p.V25F		NM_080617.5	NP_542184.1	Q9NTU7	CBLN4_HUMAN	cerebellin 4 precursor	25						cell junction|extracellular region|synapse				endometrium(2)|large_intestine(1)|lung(10)|ovary(3)|pancreas(1)	17			Colorectal(105;0.202)			TGTGCCCAGACGGGCAGCCCC	0.721000													17	20					3.45872e-05	3.69321e-05	1	1	0
CCT6P3	643180	broad.mit.edu	37	7	64534215	64534215	+	RNA	SNP	C	C	A			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr7:64534215C>A	ENST00000426828.1	+	0	1362					NR_033416.1																						AATGTCTTCTCTGAAAGGTTG	0.408000													31	2					9.04072e-19	1.03557e-18	1	1	0
KCNC2	3747	broad.mit.edu	37	12	75444305	75444305	+	Missense_Mutation	SNP	T	T	C			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr12:75444305T>C	ENST00000549446.1	-	3	2160	c.1480A>G	c.(1480-1482)Aag>Gag	p.K494E	KCNC2_ENST00000350228.2_Missense_Mutation_p.K494E|KCNC2_ENST00000550433.1_Missense_Mutation_p.K494E|KCNC2_ENST00000540018.1_Missense_Mutation_p.K494E|KCNC2_ENST00000393288.2_Missense_Mutation_p.K494E|KCNC2_ENST00000341669.3_Missense_Mutation_p.K494E|KCNC2_ENST00000548243.1_5'UTR|KCNC2_ENST00000548513.1_Missense_Mutation_p.K494E|KCNC2_ENST00000298972.1_Missense_Mutation_p.K494E	NM_001260497.1|NM_139137.3	NP_001247426.1|NP_631875.1	Q96PR1	KCNC2_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 2	494					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(28)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	54						ATGTGCTTCTTTCTTTTCCTT	0.448000													33	9					0	0	1	0	0
OR1S1	219959	broad.mit.edu	37	11	57982324	57982324	+	Silent	SNP	T	T	C			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr11:57982324T>C	ENST00000309433.6	+	1	108	c.108T>C	c.(106-108)caT>caC	p.H36H		NM_001004458.1	NP_001004458.1	Q8NH92	OR1S1_HUMAN	olfactory receptor, family 1, subfamily S, member 1	36					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(24)|kidney(1)|large_intestine(1)|liver(1)|lung(10)|prostate(1)|skin(2)|stomach(3)|urinary_tract(3)	48		Breast(21;0.0589)				AGGATGAGCATCAAAACCTCC	0.433000													57	77					0	0	1	0	0
CCNG2	901	broad.mit.edu	37	4	78082847	78082847	+	Missense_Mutation	SNP	T	T	A			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr4:78082847T>A	ENST00000316355.5	+	6	1008	c.652T>A	c.(652-654)Ttg>Atg	p.L218M	CCNG2_ENST00000354403.5_Missense_Mutation_p.L218M|CCNG2_ENST00000509972.1_Missense_Mutation_p.L218M|CCNG2_ENST00000395640.1_Missense_Mutation_p.L218M|CCNG2_ENST00000497512.1_3'UTR|CCNG2_ENST00000502280.1_Missense_Mutation_p.L218M	NM_004354.2	NP_004345.1	Q16589	CCNG2_HUMAN	cyclin G2	218					cell cycle checkpoint|cell division|mitosis	cytoplasm				breast(1)|kidney(2)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	10						AGTGGAAACTTTGAAATCTGT	0.274000													14	19					0	0	1	0	0
ITGB8	3696	broad.mit.edu	37	7	20444339	20444339	+	Silent	SNP	C	C	T			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr7:20444339C>T	ENST00000222573.4	+	11	2460	c.1776C>T	c.(1774-1776)caC>caT	p.H592H	ITGB8_ENST00000537992.1_Silent_p.H457H	NM_002214.2	NP_002205.1	P26012	ITB8_HUMAN	integrin, beta 8		Cysteine-rich tandem repeats.				cell-matrix adhesion|integrin-mediated signaling pathway|placenta blood vessel development	integrin complex	protein binding|receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(17)|prostate(2)|skin(4)|stomach(2)|urinary_tract(1)	37						CAGCCCAGCACTGTGTCAATT	0.572000													25	28					0	0	1	0	0
GPC1	2817	broad.mit.edu	37	2	241404342	241404342	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr2:241404342G>A	ENST00000264039.2	+	6	1332	c.1084G>A	c.(1084-1086)Ggc>Agc	p.G362S		NM_002081.2	NP_002072.2	P35052	GPC1_HUMAN	glypican 1	362					axon guidance	anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(4)|prostate(1)	9		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;4.51e-33)|all cancers(36;1.74e-30)|OV - Ovarian serous cystadenocarcinoma(60;4.73e-15)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;9.1e-06)|Colorectal(34;0.000487)|Lung(119;0.0013)|LUSC - Lung squamous cell carcinoma(224;0.0154)|COAD - Colon adenocarcinoma(134;0.0194)|READ - Rectum adenocarcinoma(96;0.0949)		GCGGCGCCGGGGCAAGCTGGC	0.697000													4	0					0	0	1	0	0
PCDH1	5097	broad.mit.edu	37	5	141248274	141248274	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr5:141248274C>T	ENST00000287008.3	-	2	910	c.763G>A	c.(763-765)Ggc>Agc	p.G255S	PCDH1_ENST00000536585.1_Missense_Mutation_p.G233S|PCDH1_ENST00000456271.1_Missense_Mutation_p.G243S|PCDH1_ENST00000503492.1_Missense_Mutation_p.G255S|PCDH1_ENST00000394536.3_Missense_Mutation_p.G255S	NM_032420.2	NP_115796.2	Q08174	PCDH1_HUMAN	protocadherin 1	255	Cadherin 2.				cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(4)|lung(20)|ovary(5)|skin(3)|upper_aerodigestive_tract(1)	51		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		GGGCTGCCGCCATCCTGCACC	0.627000													35	26					0	0	1	0	0
ZNF319	57567	broad.mit.edu	37	16	58031995	58031995	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr16:58031995C>T	ENST00000299237.2	-	2	797	c.175G>A	c.(175-177)Ggc>Agc	p.G59S		NM_020807.1	NP_065858.1	Q9P2F9	ZN319_HUMAN	zinc finger protein 319	59	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(2)|lung(4)|ovary(1)|urinary_tract(1)	8						GGCTGCAGGCCGGGGTCTGGC	0.697000													25	46					0	0	1	0	0
IGSF8	93185	broad.mit.edu	37	1	160068207	160068209	+	In_Frame_Del	DEL	AGC	AGC	-			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr1:160068207_160068209delAGC	ENST00000368086.1	-	1	270_272	c.54_56delGCT	c.(52-57)ctgcta>cta	p.18_19LL>L	IGSF8_ENST00000314485.7_In_Frame_Del_p.18_19LL>L			Q969P0	IGSF8_HUMAN	immunoglobulin superfamily, member 8	18					cell proliferation|cellular component movement|nervous system development|single fertilization|skeletal muscle tissue development	integral to membrane	protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(19)|pancreas(1)|prostate(1)|skin(1)	33	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			ACCTAGCATTagcagcagcagca	0.709													2	4	---	---	---	---					
LINC00570	100874055	broad.mit.edu	37	2	11542812	11542814	+	RNA	DEL	CCA	CCA	-			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr2:11542812_11542814delCCA	ENST00000417473.2	+	0	939_941					NR_047499.1																						gccatcaccgccaccaccaccac	0.586													2	4	---	---	---	---					
LOC442028	442028	broad.mit.edu	37	2	95552667	95552669	+	RNA	DEL	CTC	CTC	-			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr2:95552667_95552669delCTC	ENST00000568768.1	-	0	476																											GAAGGTCTGACTCCTCATGTATC	0.369													13	23	---	---	---	---					
CHD4	1108	broad.mit.edu	37	12	6711207	6711209	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-CF-A5UA-01A-11D-A289-08	TCGA-CF-A5UA-10A-01D-A289-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e822a8e-36da-45bf-a4fa-71a85e615a97	f7f29a52-4414-4605-9fab-e4df5f4d2a08	g.chr12:6711207_6711209delCTT	ENST00000309577.6	-	4	518_520	c.355_357delAAG	c.(355-357)aagdel	p.K119del	CHD4_ENST00000357008.2_In_Frame_Del_p.K119del|CHD4_ENST00000544040.1_In_Frame_Del_p.K112del|CHD4_ENST00000544484.1_In_Frame_Del_p.K116del			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	119	Poly-Lys.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding	p.K119delK(3)		central_nervous_system(2)	2						TAGGTCCAAGCTTCTTCTTCTTC	0.537													7	138	---	---	---	---