Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NLRP3	114548	broad.mit.edu	37	1	247607294	247607294	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr1:247607294C>T	ENST00000366497.2	+	7	3299	c.2519C>T	c.(2518-2520)aCg>aTg	p.T840M	NLRP3_ENST00000366496.2_Missense_Mutation_p.T840M|NLRP3_ENST00000391828.3_Missense_Mutation_p.T897M|NLRP3_ENST00000336119.3_Missense_Mutation_p.T897M|NLRP3_ENST00000391827.2_Missense_Mutation_p.T840M|NLRP3_ENST00000348069.2_Missense_Mutation_p.T783M	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	897					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			TCTGGCCTTACGTCAGTCTGT	0.512000													19	30					0	0	1	0	0
TNFRSF10A	8797	broad.mit.edu	37	8	23056899	23056899	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr8:23056899C>G	ENST00000221132.3	-	8	958	c.894G>C	c.(892-894)gaG>gaC	p.E298D		NM_003844.3	NP_003835.3	O00220	TR10A_HUMAN	tumor necrosis factor receptor superfamily, member 10a	298					activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors		caspase activator activity|death receptor activity|TRAIL binding|transcription factor binding			NS(2)|central_nervous_system(3)|endometrium(2)|large_intestine(3)|lung(1)|ovary(3)|prostate(1)|skin(1)	16		Prostate(55;0.0421)|Breast(100;0.14)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)		TGCTCAGAATCTCGTTGTGAG	0.562000													67	11					0	0	1	0	0
CHRNA3	1136	broad.mit.edu	37	15	78894529	78894529	+	Missense_Mutation	SNP	G	G	A	rs112696857		TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr15:78894529G>A	ENST00000326828.5	-	5	839	c.455C>T	c.(454-456)cCg>cTg	p.P152L	CHRNA3_ENST00000348639.3_Missense_Mutation_p.P152L	NM_000743.4	NP_000734.2	P32297	ACHA3_HUMAN	cholinergic receptor, nicotinic, alpha 3 (neuronal)	152					activation of transmembrane receptor protein tyrosine kinase activity|behavioral response to nicotine|locomotory behavior|regulation of acetylcholine secretion|regulation of dendrite morphogenesis|regulation of excitatory postsynaptic membrane potential|regulation of smooth muscle contraction|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|dendrite|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic density|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						AAAGATGGCCGGAGGTATCCA	0.502000													3	107					0	0	1	0	0
THEMIS	387357	broad.mit.edu	37	6	128040858	128040858	+	Missense_Mutation	SNP	G	G	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr6:128040858G>T	ENST00000368250.1	-	6	2130	c.1632C>A	c.(1630-1632)agC>agA	p.S544R	THEMIS_ENST00000537166.1_Missense_Mutation_p.S588R|THEMIS_ENST00000543064.1_Missense_Mutation_p.S662R|THEMIS_ENST00000368248.2_Missense_Mutation_p.S623R			Q8N1K5	THMS1_HUMAN	thymocyte selection associated	623					negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(3)	60						CCCCACGGTTGCTCCTTTCTT	0.438000													40	47					2.52991e-16	2.69857e-16	1	1	0
KRTAP27-1	643812	broad.mit.edu	37	21	31709534	31709534	+	Silent	SNP	G	G	A			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr21:31709534G>A	ENST00000382835.2	-	1	478	c.453C>T	c.(451-453)ttC>ttT	p.F151F		NM_001077711.1	NP_001071179.1	Q3LI81	KR271_HUMAN	keratin associated protein 27-1	151						intermediate filament		p.F151F(2)		endometrium(2)|large_intestine(3)|lung(9)|ovary(2)|prostate(1)|skin(1)	18						CCAGAGTTTCGAAATTTTTAG	0.493000													81	100					0	0	1	0	0
TMCC2	9911	broad.mit.edu	37	1	205210891	205210891	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr1:205210891C>T	ENST00000358024.3	+	2	855	c.466C>T	c.(466-468)Cgc>Tgc	p.R156C	TMCC2_ENST00000495538.1_3'UTR|TMCC2_ENST00000545499.1_Missense_Mutation_p.R78C	NM_014858.3	NP_055673.2	O75069	TMCC2_HUMAN	transmembrane and coiled-coil domain family 2	156						integral to membrane	protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|liver(2)|lung(3)|pancreas(1)|skin(1)|urinary_tract(1)	20	Breast(84;0.0871)		BRCA - Breast invasive adenocarcinoma(75;0.117)			GCAGCAGATCCGCTCCCGGCC	0.706000													7	18					0	0	1	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84651669	84651669	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr15:84651669G>C	ENST00000286744.5	+	21	3513	c.3289G>C	c.(3289-3291)Gat>Cat	p.D1097H	ADAMTSL3_ENST00000567476.1_Missense_Mutation_p.D1097H	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	1097						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			AGCCCAGTTTGATGAGCTGAT	0.473000													31	64					0	0	1	0	0
ZNF737	100129842	broad.mit.edu	37	19	20728097	20728097	+	Silent	SNP	C	C	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr19:20728097C>T	ENST00000427401.4	-	4	1006	c.912G>A	c.(910-912)aaG>aaA	p.K304K		NM_001159293.1	NP_001152765.1	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	304					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(2)|kidney(1)|lung(7)|ovary(1)|stomach(1)|urinary_tract(1)	13						TATGAATTATCTTATGCGCAG	0.408000													30	44					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82451883	82451883	+	Missense_Mutation	SNP	T	T	C			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr7:82451883T>C	ENST00000333891.9	-	20	15056	c.14719A>G	c.(14719-14721)Acc>Gcc	p.T4907A	PCLO_ENST00000426442.2_5'UTR|PCLO_ENST00000423517.2_Missense_Mutation_p.T4907A	NM_033026.5	NP_149015.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein						cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TCCAGGTGGGTCTGAGTGACG	0.502000													77	165					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179394807	179394807	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr2:179394807C>G	ENST00000589042.1	-	359	106635	c.106411G>C	c.(106411-106413)Gac>Cac	p.D35471H	TTN-AS1_ENST00000592836.1_RNA|TTN-AS1_ENST00000604571.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000585358.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.D32903H|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000591867.1_RNA|TTN-AS1_ENST00000585487.1_RNA|TTN-AS1_ENST00000589842.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000431259.2_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000588244.1_RNA|TTN-AS1_ENST00000587944.1_RNA|TTN-AS1_ENST00000588257.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.D26531H|TTN-AS1_ENST00000588804.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.D26598H|TTN-AS1_ENST00000590040.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.D26406H|TTN-AS1_ENST00000587568.1_RNA|TTN-AS1_ENST00000442329.2_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000588716.1_RNA|TTN-AS1_ENST00000592182.1_RNA|TTN-AS1_ENST00000589434.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000585625.1_RNA|TTN-AS1_ENST00000591466.1_RNA|TTN-AS1_ENST00000589391.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000450692.2_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.D33830H	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	33830							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTCCCTTGTCTTCAGAGAGT	0.348000													13	26					0	0	1	0	0
PRDM9	56979	broad.mit.edu	37	5	23527693	23527693	+	Silent	SNP	T	T	C			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr5:23527693T>C	ENST00000296682.3	+	11	2678	c.2496T>C	c.(2494-2496)taT>taC	p.Y832Y		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	832					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding	p.Y832Y(1)		NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						AGAAGCCCTATGTCTGCAGGG	0.587000										HNSCC(3;0.000094)			5	331					0	0	1	0	0
ATG16L1	55054	broad.mit.edu	37	2	234183394	234183394	+	Silent	SNP	G	G	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr2:234183394G>T	ENST00000392017.4	+	9	1181	c.924G>T	c.(922-924)gtG>gtT	p.V308V	ATG16L1_ENST00000347464.5_Silent_p.V145V|ATG16L1_ENST00000392020.4_Silent_p.V289V|ATG16L1_ENST00000373525.5_Silent_p.V164V|ATG16L1_ENST00000392018.1_Silent_p.V325V|ATG16L1_ENST00000498620.1_3'UTR	NM_001190266.1|NM_001190267.1|NM_030803.6	NP_001177195.1|NP_001177196.1|NP_110430.5	Q676U5	A16L1_HUMAN	autophagy related 16-like 1 (S. cerevisiae)	308					autophagic vacuole assembly|protein homooligomerization|protein transport	autophagic vacuole|pre-autophagosomal structure membrane	protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(7)|prostate(3)|skin(1)	25		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0539)		Epithelial(121;1.53e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000379)|LUSC - Lung squamous cell carcinoma(224;0.00619)|Lung(119;0.00732)|GBM - Glioblastoma multiforme(43;0.11)		GTAAAGAAGTGAGGGTACCAG	0.473000													34	34					2.35958e-20	2.5509e-20	1	1	0
MUC16	94025	broad.mit.edu	37	19	9090831	9090831	+	Silent	SNP	A	A	G			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr19:9090831A>G	ENST00000397910.4	-	1	1187	c.984T>C	c.(982-984)ccT>ccC	p.P328P		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	328	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCATGGAAAAAGGGATAGCTG	0.522000													3	86					0	0	1	0	0
TMEM55A	55529	broad.mit.edu	37	8	92008912	92008912	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr8:92008912C>T	ENST00000285419.3	-	6	914	c.600G>A	c.(598-600)atG>atA	p.M200I		NM_018710.2	NP_061180.1	Q8N4L2	TM55A_HUMAN	transmembrane protein 55A	200						integral to membrane|late endosome membrane|lysosomal membrane	hydrolase activity	p.M200_G206delMICIFIG(1)		breast(1)|endometrium(2)|large_intestine(5)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	13			BRCA - Breast invasive adenocarcinoma(11;0.033)			AAATACATATCATTCCAATGG	0.393000													14	36					0	0	1	0	0
ADH6	130	broad.mit.edu	37	4	100137347	100137347	+	Missense_Mutation	SNP	G	G	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr4:100137347G>T	ENST00000394897.1	-	2	173	c.91C>A	c.(91-93)Cca>Aca	p.P31T	ADH6_ENST00000394899.2_Missense_Mutation_p.P31T|RP11-696N14.1_ENST00000500358.2_RNA|RP11-696N14.1_ENST00000506454.1_RNA|RP11-696N14.1_ENST00000506160.1_RNA|ADH6_ENST00000407820.2_5'UTR|ADH6_ENST00000237653.7_Missense_Mutation_p.P31T			P28332	ADH6_HUMAN	alcohol dehydrogenase 6 (class V)	31					ethanol oxidation|response to ethanol|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|electron carrier activity|zinc ion binding			breast(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(2)	20				OV - Ovarian serous cystadenocarcinoma(123;3.58e-08)	Abacavir(DB01048)|NADH(DB00157)	GCCTTTGGTGGGGCCACTTCT	0.403000													32	45					6.45866e-13	6.79859e-13	1	1	0
UMODL1	89766	broad.mit.edu	37	21	43519101	43519101	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr21:43519101C>T	ENST00000400424.2	+	7	1177	c.781C>T	c.(781-783)Cgt>Tgt	p.R261C	UMODL1_ENST00000408989.2_Missense_Mutation_p.R333C|UMODL1_ENST00000408910.2_Missense_Mutation_p.R333C|UMODL1_ENST00000400427.1_Missense_Mutation_p.R261C	NM_001199528.2	NP_001186457	Q5DID0	UROL1_HUMAN	uromodulin-like 1							cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(22)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	47						AGTATCCTGGCGTTTAAATTC	0.522000													5	119					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179428319	179428319	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr2:179428319C>T	ENST00000589042.1	-	326	82764	c.82540G>A	c.(82540-82542)Gtt>Att	p.V27514I	TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.V24946I|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.V18574I|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.V18641I|TTN_ENST00000460472.2_Missense_Mutation_p.V18449I|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.V25873I	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	25873	Fibronectin type-III 100.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTCCATCTAACGCCTTCCTTA	0.463000													59	65					0	0	1	0	0
ZFP69B	65243	broad.mit.edu	37	1	40928396	40928396	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr1:40928396G>C	ENST00000411995.2	+	6	1115	c.740G>C	c.(739-741)aGa>aCa	p.R247T	ZFP69B_ENST00000361584.3_Missense_Mutation_p.R145T|ZFP69B_ENST00000484445.1_3'UTR	NM_023070.2	NP_075558.2			ZFP69 zinc finger protein B																		GGTCTTCCAAGAAAAAGAGAT	0.348000													53	57					0	0	1	0	0
F11	2160	broad.mit.edu	37	4	187209661	187209661	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr4:187209661G>A	ENST00000264692.4	+	15	1948	c.1615G>A	c.(1615-1617)Ggc>Agc	p.G539S	F11_ENST00000403665.2_Missense_Mutation_p.G591S|F11-AS1_ENST00000505103.1_RNA			P03951	FA11_HUMAN	coagulation factor XI	591	Peptidase S1.				blood coagulation, intrinsic pathway|plasminogen activation|positive regulation of fibrinolysis	extracellular space|plasma membrane	heparin binding|serine-type endopeptidase activity			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(15)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	32		all_cancers(14;6.2e-52)|all_epithelial(14;1.62e-38)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;2.13e-11)|BRCA - Breast invasive adenocarcinoma(30;4.59e-06)|GBM - Glioblastoma multiforme(59;0.000149)|STAD - Stomach adenocarcinoma(60;0.000314)|LUSC - Lung squamous cell carcinoma(40;0.00112)|READ - Rectum adenocarcinoma(43;0.176)	Coagulation Factor IX(DB00100)	GCATCTGGTAGGCATCACGAG	0.552000													53	82					0	0	1	0	0
TMEM138	51524	broad.mit.edu	37	11	61133705	61133705	+	Silent	SNP	G	G	A			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr11:61133705G>A	ENST00000542946.1	+	3	516	c.317G>A	c.(316-318)tGa>tAa	p.*106*	TMEM138_ENST00000278826.6_Intron|TMEM138_ENST00000540194.1_Intron|TMEM138_ENST00000381787.2_Intron			Q9NPI0	TM138_HUMAN	transmembrane protein 138	0						integral to membrane				central_nervous_system(1)|large_intestine(2)|lung(1)|upper_aerodigestive_tract(1)	5						GTGGCAGTCTGAATTCTTTTT	0.433000													21	35					0	0	1	0	0
RRN3P1	730092	broad.mit.edu	37	16	21817457	21817457	+	RNA	SNP	G	G	A	rs150520281	by1000genomes	TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr16:21817457G>A	ENST00000546471.1	-	0	1601																											CTTACATCCAGCTTGAGTAGT	0.259000													3	27					0	0	1	0	0
C2orf66	401027	broad.mit.edu	37	2	197672317	197672317	+	Silent	SNP	C	C	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr2:197672317C>T	ENST00000342506.2	-	2	1092	c.204G>A	c.(202-204)aaG>aaA	p.K68K		NM_213608.2	NP_998773.1	Q6UXQ4	CB066_HUMAN	chromosome 2 open reading frame 66	68						extracellular region				endometrium(2)|large_intestine(2)|lung(4)|ovary(1)	9						GACCTCTGCCCTTAAAATATG	0.388000													41	74					0	0	1	0	0
TMLHE	55217	broad.mit.edu	37	X	154743712	154743712	+	Missense_Mutation	SNP	G	G	T	rs145115289	byFrequency	TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chrX:154743712G>T	ENST00000334398.3	-	4	718	c.573C>A	c.(571-573)ttC>ttA	p.F191L	TMLHE_ENST00000369439.4_Missense_Mutation_p.F191L|TMLHE-AS1_ENST00000452506.1_RNA	NM_018196.3	NP_060666.1	Q9NVH6	TMLH_HUMAN	trimethyllysine hydroxylase, epsilon	191					carnitine biosynthetic process	mitochondrial matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|trimethyllysine dioxygenase activity	p.F191L(1)		breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	20	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Succinic acid(DB00139)|Vitamin C(DB00126)	CATTTTCTACGAATGCAATTC	0.418000													4	81					0.184627	0.184627	1	1	0
ZFYVE19	84936	broad.mit.edu	37	15	41105570	41105570	+	Silent	SNP	T	T	C			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr15:41105570T>C	ENST00000355341.4	+	8	1566	c.1065T>C	c.(1063-1065)gaT>gaC	p.D355D	ZFYVE19_ENST00000570108.1_Silent_p.D332D|ZFYVE19_ENST00000564258.1_Silent_p.D180D|ZFYVE19_ENST00000336455.5_Silent_p.D345D|ZFYVE19_ENST00000299173.10_Silent_p.D287D	NM_001077268.1	NP_001070736.1	Q96K21	ZFY19_HUMAN	zinc finger, FYVE domain containing 19	355							zinc ion binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	9		all_cancers(109;3.31e-18)|all_epithelial(112;2.33e-15)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.76e-05)|COAD - Colon adenocarcinoma(120;0.151)|BRCA - Breast invasive adenocarcinoma(123;0.164)		CAGACAGTGATGACGACGAGG	0.587000													9	23					0	0	1	0	0
C15orf39	56905	broad.mit.edu	37	15	75501097	75501097	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr15:75501097G>A	ENST00000360639.2	+	2	3028	c.2708G>A	c.(2707-2709)cGc>cAc	p.R903H	C15orf39_ENST00000394987.4_Missense_Mutation_p.R903H|C15orf39_ENST00000567617.1_Missense_Mutation_p.R903H			Q6ZRI6	CO039_HUMAN	chromosome 15 open reading frame 39	903										autonomic_ganglia(1)|breast(2)|endometrium(3)|large_intestine(4)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	16						CTGGCGCTGCGCCAGCTGCCG	0.697000													22	19					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	68950493	68950493	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr8:68950493G>A	ENST00000288368.4	+	7	1082	c.805G>A	c.(805-807)Gat>Aat	p.D269N	PREX2_ENST00000529398.1_3'UTR	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	269	PH.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						TTTTCTTTTCGATAATCTTTT	0.418000													21	57					0	0	1	0	0
OTUD4	54726	broad.mit.edu	37	4	146059041	146059041	+	Silent	SNP	A	A	G			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr4:146059041A>G	ENST00000454497.2	-	21	2828	c.2691T>C	c.(2689-2691)caT>caC	p.H897H	OTUD4_ENST00000447906.2_Silent_p.H962H|OTUD4_ENST00000455611.2_Intron	NM_001102653.1	NP_001096123.1	Q01804	OTUD4_HUMAN	OTU domain containing 4	961							protein binding			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(10)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33	all_hematologic(180;0.151)					GAGTGGGAGGATGAGCCTTTC	0.478000													4	193					0	0	1	0	0
RANBP6	26953	broad.mit.edu	37	9	6012658	6012658	+	Missense_Mutation	SNP	T	T	G			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr9:6012658T>G	ENST00000259569.5	-	1	2960	c.2950A>C	c.(2950-2952)Ata>Cta	p.I984L		NM_001243202.1|NM_001243203.1|NM_012416.3	NP_001230131.1|NP_001230132.1|NP_036548.1	O60518	RNBP6_HUMAN	RAN binding protein 6	984					protein transport	cytoplasm|nucleus	binding	p.I984L(4)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(5)|large_intestine(8)|lung(9)|ovary(7)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	51		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)		ATCTTCCCTATTGCTGAGATA	0.363000													5	42					0	0	1	0	0
CATSPERG	57828	broad.mit.edu	37	19	38847487	38847487	+	Missense_Mutation	SNP	T	T	C			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr19:38847487T>C	ENST00000409235.3	+	11	1416	c.1301T>C	c.(1300-1302)gTc>gCc	p.V434A	CATSPERG_ENST00000410018.1_Intron|CATSPERG_ENST00000215069.4_Missense_Mutation_p.V427A	NM_021185.4	NP_067008.3	Q6ZRH7	CTSRG_HUMAN	catsper channel auxiliary subunit gamma	434					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(13)|ovary(1)|pancreas(2)|prostate(6)|skin(3)|stomach(1)|urinary_tract(2)	40						TTCCAGGTGGTCAGCTACAAC	0.527000													74	99					0	0	1	0	0
ZNF878	729747	broad.mit.edu	37	19	12155673	12155673	+	Missense_Mutation	SNP	A	A	C			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr19:12155673A>C	ENST00000602107.1	-	5	683	c.684T>G	c.(682-684)agT>agG	p.S228R	CTD-2006C1.2_ENST00000476474.1_RNA|CTD-2006C1.2_ENST00000591898.1_RNA|ZNF878_ENST00000547628.1_Missense_Mutation_p.S181R|CTD-2006C1.10_ENST00000547473.1_Intron|CTD-2006C1.2_ENST00000591838.1_RNA			C9JN71	ZN878_HUMAN	zinc finger protein 878	181					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|lung(4)|urinary_tract(1)	8						AACTGGGAAAACTGAATGCTT	0.403000													5	266					0	0	1	0	0
GIT2	9815	broad.mit.edu	37	12	110391020	110391020	+	Silent	SNP	C	C	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr12:110391020C>T	ENST00000360185.4	-	13	1283	c.1119G>A	c.(1117-1119)ctG>ctA	p.L373L	GIT2_ENST00000354574.4_Silent_p.L375L|GIT2_ENST00000553118.1_Silent_p.L373L|GIT2_ENST00000457474.2_Silent_p.L375L|TCHP_ENST00000550780.1_Intron|GIT2_ENST00000356259.4_Silent_p.L373L|GIT2_ENST00000343646.5_Intron|GIT2_ENST00000551209.1_Silent_p.L372L|GIT2_ENST00000320063.9_Silent_p.L373L|GIT2_ENST00000361006.5_Silent_p.L373L|GIT2_ENST00000355312.3_Silent_p.L373L|GIT2_ENST00000338373.5_Silent_p.L373L|GIT2_ENST00000547815.1_Silent_p.L373L	NM_014776.3	NP_055591.2	Q14161	GIT2_HUMAN	G protein-coupled receptor kinase interacting ArfGAP 2	373					regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	nucleoplasm	ARF GTPase activator activity|protein binding|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(8)|skin(4)	27						TGATGGTTTTCAGTATGAGCT	0.413000													48	134					0	0	1	0	0
KRTAP4-12	83755	broad.mit.edu	37	17	39280114	39280114	+	Silent	SNP	T	T	C			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr17:39280114T>C	ENST00000394014.1	-	1	305	c.261A>G	c.(259-261)agA>agG	p.R87R		NM_031854.2	NP_114060.1	Q9BQ66	KR412_HUMAN	keratin associated protein 4-12	87	31 X 5 AA repeats of C-C-[GRQVIL]-[SPTR]- [VSTQPC].					keratin filament		p.R87R(3)		endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	13		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			AGCACTGGGGTCTGCAGCAGC	0.677000													4	199					0	0	1	0	0
GALNT8	26290	broad.mit.edu	37	12	4835915	4835915	+	Silent	SNP	C	C	G			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr12:4835915C>G	ENST00000252318.2	+	2	766	c.429C>G	c.(427-429)ctC>ctG	p.L143L	RP11-234B24.6_ENST00000544741.2_3'UTR	NM_017417.1	NP_059113.1	Q9NY28	GALT8_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)	143						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	35						CCCAGGACCTCTTCCGGAAGT	0.557000													85	44					0	0	1	0	0
CILP2	148113	broad.mit.edu	37	19	19655933	19655933	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr19:19655933G>A	ENST00000586018.1	+	8	2699	c.2597G>A	c.(2596-2598)cGc>cAc	p.R866H	CILP2_ENST00000291495.5_Missense_Mutation_p.R860H			Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	860						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	32						AACGGCTTCCGCATCAACCTC	0.701000													4	76					0	0	1	0	0
ZFAND4	93550	broad.mit.edu	37	10	46121709	46121709	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr10:46121709G>A	ENST00000374366.3	-	8	1805	c.1340C>T	c.(1339-1341)tCt>tTt	p.S447F	ZFAND4_ENST00000344646.5_Missense_Mutation_p.S521F|ZFAND4_ENST00000374370.1_5'UTR|ZFAND4_ENST00000374371.2_Intron	NM_001282905.1|NM_001282906.1	NP_001269834.1|NP_001269835.1	Q86XD8	ANUB1_HUMAN	zinc finger, AN1-type domain 4	521							zinc ion binding										AGTAGTCCTAGAGAAAGAAGA	0.393000													5	69					0	0	1	0	0
AADACL4	343066	broad.mit.edu	37	1	12726726	12726726	+	Missense_Mutation	SNP	A	A	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr1:12726726A>T	ENST00000376221.1	+	4	1204	c.1204A>T	c.(1204-1206)Agt>Tgt	p.S402C		NM_001013630.1	NP_001013652.1	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	402						integral to membrane	carboxylesterase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)	17	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		TGCTGTAGTCAGTTATATAAA	0.438000													5	85					0	0	1	0	0
OR6Q1	219952	broad.mit.edu	37	11	57798438	57798438	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr11:57798438C>T	ENST00000302622.3	+	1	37	c.14C>T	c.(13-15)aCc>aTc	p.T5I	OR9Q1_ENST00000335397.3_Intron	NM_001005186.2	NP_001005186.2	Q8NGQ2	OR6Q1_HUMAN	olfactory receptor, family 6, subfamily Q, member 1	5					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			biliary_tract(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Breast(21;0.0707)|all_epithelial(135;0.142)				CAACCATATACCAAAAACTGG	0.458000													8	205					0	0	1	0	0
DCP1B	196513	broad.mit.edu	37	12	2062350	2062350	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr12:2062350C>G	ENST00000280665.6	-	7	835	c.756G>C	c.(754-756)caG>caC	p.Q252H	DCP1B_ENST00000541700.1_5'UTR|DCP1B_ENST00000540622.1_Missense_Mutation_p.Q126H|DCP1B_ENST00000397173.4_Missense_Mutation_p.Q150H	NM_152640.3	NP_689853.3	Q8IZD4	DCP1B_HUMAN	decapping mRNA 1B	252	Poly-Gln.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	hydrolase activity|protein binding	p.Q252H(8)		NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(3)|lung(10)|skin(1)	24			OV - Ovarian serous cystadenocarcinoma(31;0.00193)			gctgctgctgctgGTGGAGAG	0.552000													3	70					0	0	1	0	0
ZNF681	148213	broad.mit.edu	37	19	23927314	23927314	+	Silent	SNP	G	G	A			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr19:23927314G>A	ENST00000402377.3	-	4	1179	c.1038C>T	c.(1036-1038)gcC>gcT	p.A346A	ZNF681_ENST00000395385.3_Silent_p.A277A	NM_138286.2	NP_612143.2	Q96N22	ZN681_HUMAN	zinc finger protein 681	346					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|prostate(1)|skin(1)|urinary_tract(3)	21		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				ACTGGTTAAAGGCTTTGCCAC	0.433000													5	158					0	0	1	0	0
PDP1	54704	broad.mit.edu	37	8	94934837	94934837	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr8:94934837C>T	ENST00000396200.3	+	3	901	c.625C>T	c.(625-627)Cgg>Tgg	p.R209W	PDP1_ENST00000520728.1_Missense_Mutation_p.R184W|PDP1_ENST00000297598.4_Missense_Mutation_p.R184W|PDP1_ENST00000517764.1_Missense_Mutation_p.R184W	NM_001161779.1	NP_001155251.1	Q9P0J1	PDP1_HUMAN	pyruvate dehyrogenase phosphatase catalytic subunit 1	184					pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix|protein serine/threonine phosphatase complex	[pyruvate dehydrogenase (lipoamide)] phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|liver(1)|lung(5)|ovary(1)|pancreas(1)|skin(2)	18						GGAGAGCGGCCGGGCACTGCT	0.453000													29	49					0	0	1	0	0
GUSBP1	728411	broad.mit.edu	37	5	21497235	21497235	+	RNA	SNP	C	C	T	rs141635554	by1000genomes	TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr5:21497235C>T	ENST00000607545.1	+	0	179					NR_027026.1																						AGTTTGAGAACTGGTGTAAGA	0.488000													4	119					0	0	1	0	0
NELFA	7469	broad.mit.edu	37	4	1985711	1985711	+	Missense_Mutation	SNP	G	G	A	rs149343602		TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr4:1985711G>A	ENST00000382882.3	-	9	2316	c.1199C>T	c.(1198-1200)gCg>gTg	p.A400V	NELFA_ENST00000411638.2_Missense_Mutation_p.A389V|NELFA_ENST00000542778.1_Missense_Mutation_p.A254V					negative elongation factor complex member A																		GGTGGGCGCCGCAGGCGTGGG	0.716000													3	34					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37430948	37430948	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr10:37430948C>G	ENST00000374660.1	+	7	1054	c.955C>G	c.(955-957)Cca>Gca	p.P319A	ANKRD30A_ENST00000361713.1_Missense_Mutation_p.P319A|ANKRD30A_ENST00000602533.1_Missense_Mutation_p.P319A			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	375						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						ATTTACGTGGCCAGCAAAAGG	0.423000													3	115					0	0	1	0	0
LCE3D	84648	broad.mit.edu	37	1	152552263	152552263	+	Silent	SNP	G	G	A	rs139649941		TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr1:152552263G>A	ENST00000368787.3	-	2	206	c.150C>T	c.(148-150)ggC>ggT	p.G50G		NM_032563.1	NP_115952.1	Q9BYE3	LCE3D_HUMAN	late cornified envelope 3D	50					keratinization					breast(1)|endometrium(1)|large_intestine(2)|lung(7)|pancreas(1)|skin(1)|stomach(2)	15	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)	UCEC - Uterine corpus endometrioid carcinoma (5;0.153)|KIRC - Kidney renal clear cell carcinoma(4;0.0323)|Kidney(5;0.0378)		GGAAGCAGCCGCCCTCGGAGC	0.672000													9	67					0	0	1	0	0
KLK15	55554	broad.mit.edu	37	19	51330226	51330226	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr19:51330226C>T	ENST00000326856.4	-	4	515	c.386G>A	c.(385-387)cGt>cAt	p.R129H	KLK15_ENST00000416184.1_Intron|KLK15_ENST00000596931.1_Missense_Mutation_p.R129H|KLK15_ENST00000301421.2_Missense_Mutation_p.R130H|KLK15_ENST00000598239.1_Missense_Mutation_p.R130H	NM_001277081.1	NP_001264010.1	Q9H2R5	KLK15_HUMAN	kallikrein-related peptidase 15	130	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(12)|skin(2)|upper_aerodigestive_tract(1)	24		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.0143)		GTGGGGGCAACGCGTGGGTAG	0.706000													29	34					0	0	1	0	0
PSMB9	5698	broad.mit.edu	37	6	32825140	32825140	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr6:32825140G>A	ENST00000395330.1	+	3	308	c.160G>A	c.(160-162)Gac>Aac	p.D54N	PSMB9_ENST00000374859.2_Missense_Mutation_p.D77N|PSMB9_ENST00000453265.2_Intron			P28065	PSB9_HUMAN	proteasome (prosome, macropain) subunit, beta type, 9	77					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity			large_intestine(4)|lung(4)|skin(1)	9						AGCCGTGGCCGACATGGCCGC	0.602000													4	44					0	0	1	0	0
SARS	6301	broad.mit.edu	37	1	109777922	109777922	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr1:109777922C>T	ENST00000369923.4	+	7	849	c.838C>T	c.(838-840)Cac>Tac	p.H280Y	SARS_ENST00000234677.2_Missense_Mutation_p.H280Y			P49591	SYSC_HUMAN	seryl-tRNA synthetase	280					seryl-tRNA aminoacylation|tRNA processing	cytosol	ATP binding|protein binding|RNA binding|serine-tRNA ligase activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	17		all_epithelial(167;7.64e-05)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0301)|Lung(183;0.0677)|COAD - Colon adenocarcinoma(174;0.116)|Epithelial(280;0.233)	L-Serine(DB00133)	TGCTGCCCTGCACCGGGATGA	0.587000													51	79					0	0	1	0	0
PITPNC1	26207	broad.mit.edu	37	17	65671602	65671602	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr17:65671602G>A	ENST00000580974.1	+	8	1322	c.626G>A	c.(625-627)cGa>cAa	p.R209Q	PITPNC1_ENST00000335257.6_Missense_Mutation_p.R209Q|PITPNC1_ENST00000299954.9_Missense_Mutation_p.R209Q|PITPNC1_ENST00000581322.1_Missense_Mutation_p.R209Q	NM_012417.3|NM_181671.2	NP_036549.2|NP_858057.1	Q9UKF7	PITC1_HUMAN	phosphatidylinositol transfer protein, cytoplasmic 1	209					signal transduction	cytoplasm	lipid binding|phosphatidylinositol transporter activity|protein binding			breast(1)|kidney(2)|large_intestine(3)|liver(2)|lung(4)|prostate(2)|skin(3)	17	all_cancers(12;3.03e-10)		BRCA - Breast invasive adenocarcinoma(8;2.08e-08)|Colorectal(3;0.198)			TAGGTGGTCCGAGACATTCTG	0.373000													15	96					0	0	1	0	0
FAM110B	90362	broad.mit.edu	37	8	59059268	59059268	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr8:59059268C>T	ENST00000361488.3	+	5	1359	c.479C>T	c.(478-480)gCg>gTg	p.A160V	FAM110B_ENST00000520369.1_Intron	NM_147189.2	NP_671722.1	Q8TC76	F110B_HUMAN	family with sequence similarity 110, member B	160						microtubule organizing center|mitochondrion|nucleus				breast(1)|endometrium(3)|kidney(1)|large_intestine(10)|lung(9)|skin(2)	26		all_epithelial(80;0.025)|all_lung(136;0.0274)|Lung NSC(129;0.0355)				CACTCCTTCGCGGAGTCCCTG	0.697000													5	18					0	0	1	0	0
DOT1L	84444	broad.mit.edu	37	19	2220125	2220125	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr19:2220125G>A	ENST00000398665.3	+	23	2746	c.2710G>A	c.(2710-2712)Gtg>Atg	p.V904M		NM_032482.2	NP_115871.1	Q8TEK3	DOT1L_HUMAN	DOT1-like histone H3K79 methyltransferase	904						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(9)	42		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCCAGTCCCGTGCTGCAGCC	0.617000													5	75					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110448690	110448690	+	Splice_Site	SNP	T	T	C			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr8:110448690T>C	ENST00000378402.5	+	30	3731		c.e30+2			NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1						immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ACACCAAAAGTAAGGCCTCTG	0.393000										HNSCC(38;0.096)			26	14					0	0	1	0	0
ANKRD44	91526	broad.mit.edu	37	2	197975551	197975551	+	Missense_Mutation	SNP	A	A	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr2:197975551A>T	ENST00000328737.2	-	9	925	c.849T>A	c.(847-849)agT>agA	p.S283R	ANKRD44_ENST00000337207.5_Missense_Mutation_p.S283R|ANKRD44_ENST00000409919.1_Missense_Mutation_p.S308R|ANKRD44_ENST00000282272.8_Missense_Mutation_p.S300R|ANKRD44_ENST00000539527.1_Missense_Mutation_p.S236R|ANKRD44_ENST00000409153.1_Missense_Mutation_p.S308R|ANKRD44_ENST00000450567.1_Missense_Mutation_p.S283R			Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	308							protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(20)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	45			OV - Ovarian serous cystadenocarcinoma(117;0.246)			TGTGCAGTGGACTTTTGCCAT	0.448000													8	166					0	0	1	0	0
GUSBP1	728411	broad.mit.edu	37	5	21497311	21497311	+	RNA	SNP	C	C	T	rs138516990	by1000genomes	TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr5:21497311C>T	ENST00000607545.1	+	0	179					NR_027026.1																						ACCAGGTAAGCGGTGTTGAAC	0.537000													9	18					0	0	1	0	0
UGT2B28	54490	broad.mit.edu	37	4	70152481	70152481	+	Silent	SNP	A	A	G	rs141618560		TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr4:70152481A>G	ENST00000335568.5	+	3	884	c.882A>G	c.(880-882)gaA>gaG	p.E294E	UGT2B28_ENST00000511240.1_Silent_p.E294E	NM_053039.1	NP_444267.1	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B28	294					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity	p.E294E(1)		central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	31					Flunitrazepam(DB01544)	AAATGGAGGAATTTGTACAGA	0.393000													3	125					0	0	1	0	0
UBB	7314	broad.mit.edu	37	17	16285491	16285491	+	Silent	SNP	C	C	T	rs16962973		TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr17:16285491C>T	ENST00000302182.3	+	2	662	c.270C>T	c.(268-270)acC>acT	p.T90T	UBB_ENST00000578649.1_Intron|UBB_ENST00000535788.1_Intron|UBB_ENST00000395837.1_Silent_p.T90T|RP11-138I1.4_ENST00000583934.1_RNA|UBB_ENST00000395839.1_Silent_p.T90T	NM_001281720.1|NM_018955.3	NP_001268649.1|NP_061828.1	P0CG47	UBB_HUMAN	ubiquitin B	90	Ubiquitin-like 2.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)		AGACCATCACCCTGGAAGTGG	0.552000													3	120					0	0	1	0	0
CYP2B6	1555	broad.mit.edu	37	19	41518645	41518645	+	Missense_Mutation	SNP	G	G	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr19:41518645G>T	ENST00000324071.4	+	8	1226	c.1219G>T	c.(1219-1221)Gcc>Tcc	p.A407S	CYP2B6_ENST00000330446.5_Missense_Mutation_p.A207S|CYP2B6_ENST00000593831.1_Missense_Mutation_p.A171S	NM_000767.4	NP_000758.1	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B, polypeptide 6	407					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding	p.A407T(1)		NS(1)|breast(1)|endometrium(5)|kidney(1)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	28			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	AAAACCAGACGCCTTCAATCC	0.458000													109	101					1.16149e-67	1.27286e-67	1	1	0
MASP1	5648	broad.mit.edu	37	3	186968087	186968087	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr3:186968087C>G	ENST00000337774.5	-	8	1431	c.1042G>C	c.(1042-1044)Gag>Cag	p.E348Q	MASP1_ENST00000495249.1_Intron|MASP1_ENST00000169293.6_Missense_Mutation_p.E348Q|MASP1_ENST00000296280.6_Missense_Mutation_p.E348Q|MASP1_ENST00000392472.2_Missense_Mutation_p.E235Q|MASP1_ENST00000392470.2_Missense_Mutation_p.E322Q	NM_001879.5	NP_001870.3	P48740	MASP1_HUMAN	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	348	Sushi 1.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(2)|lung(27)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	60	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		TTCAGACACTCAATCTGGAAT	0.488000													79	136					0	0	1	0	0
SLC2A13	114134	broad.mit.edu	37	12	40499377	40499377	+	Silent	SNP	G	G	A			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr12:40499377G>A	ENST00000280871.4	-	1	284	c.234C>T	c.(232-234)ccC>ccT	p.P78P	SLC2A13_ENST00000380858.1_Silent_p.P78P	NM_052885.3	NP_443117.3	Q96QE2	MYCT_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 13	78						integral to membrane|plasma membrane	myo-inositol:hydrogen symporter activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	29		Lung NSC(34;0.105)|all_lung(34;0.123)				ACACGAAGGCGGGGGTCTCGT	0.726000										HNSCC(50;0.14)			6	7					0	0	1	0	0
SLC18B1	116843	broad.mit.edu	37	6	133111328	133111328	+	Missense_Mutation	SNP	T	T	C			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr6:133111328T>C	ENST00000538764.1	-	3	372	c.37A>G	c.(37-39)Att>Gtt	p.I13V	SLC18B1_ENST00000367918.1_Intron|SLC18B1_ENST00000460518.1_5'UTR|SLC18B1_ENST00000275227.4_Silent_p.V89V			Q6NT16	CF192_HUMAN	solute carrier family 18, subfamily B, member 1	0					transmembrane transport	integral to membrane											AGTTTCCAAATACCAAGGATG	0.313000													5	6					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45784025	45784025	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr21:45784025C>T	ENST00000397928.1	+	3	728	c.283C>T	c.(283-285)Cat>Tat	p.H95Y	TRPM2_ENST00000300482.5_Missense_Mutation_p.H95Y|TRPM2_ENST00000300481.9_Missense_Mutation_p.H95Y|TRPM2_ENST00000397932.2_Missense_Mutation_p.H95Y	NM_003307.3	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	95						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						TGGCTACACGCATGAGCAGCA	0.582000													23	23					0	0	1	0	0
TLR7	51284	broad.mit.edu	37	X	12905875	12905875	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chrX:12905875C>T	ENST00000380659.3	+	3	2387	c.2248C>T	c.(2248-2250)Cga>Tga	p.R750*		NM_016562.3	NP_057646.1	Q9NYK1	TLR7_HUMAN	toll-like receptor 7	750					cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			NS(1)|breast(4)|endometrium(5)|kidney(1)|large_intestine(8)|lung(18)|ovary(2)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	44					Imiquimod(DB00724)	CTTCCAGTTGCGATATCTGGA	0.383000													7	53					0	0	1	0	0
ATP4A	495	broad.mit.edu	37	19	36050775	36050775	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr19:36050775G>A	ENST00000262623.3	-	7	1016	c.988C>T	c.(988-990)Cgg>Tgg	p.R330W		NM_000704.2	NP_000695.2	P20648	ATP4A_HUMAN	ATPase, H+/K+ exchanging, alpha polypeptide	330					ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(26)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	53	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	ACCATGGCCCGCAGGAAGGTG	0.577000													27	27					0	0	1	0	0
FAM86DP	692099	broad.mit.edu	37	3	75475655	75475655	+	RNA	SNP	C	C	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr3:75475655C>T	ENST00000459803.1	-	0	874					NR_024241.1																						GTAAAGGCCACGTAGACCTCA	0.647000													4	88					0	0	1	0	0
WNK1	65125	broad.mit.edu	37	12	1017767	1017767	+	Missense_Mutation	SNP	A	A	G	rs144574284	by1000genomes	TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr12:1017767A>G	ENST00000537687.1	+	28	8381	c.7738A>G	c.(7738-7740)Atg>Gtg	p.M2580V	WNK1_ENST00000340908.4_Missense_Mutation_p.M1913V|WNK1_ENST00000315939.6_Missense_Mutation_p.M2320V|WNK1_ENST00000530271.2_Missense_Mutation_p.M2818V|WNK1_ENST00000535572.1_Missense_Mutation_p.M2072V	NM_001184985.1|NM_213655.4	NP_001171914.1|NP_998820.3	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	2320					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			breast(7)|central_nervous_system(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(43)|ovary(6)|prostate(3)|skin(7)|stomach(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	104	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			CACCAAGTCTATGTGCCCCCC	0.592000													64	40					0	0	1	0	0
KRT20	54474	broad.mit.edu	37	17	39032712	39032712	+	Splice_Site	SNP	T	T	A			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr17:39032712T>A	ENST00000167588.3	-	8	1219		c.e8-2			NM_019010.2	NP_061883.1	P35900	K1C20_HUMAN	keratin 20						apoptosis|intermediate filament organization	Golgi apparatus|intermediate filament	protein binding|structural constituent of cytoskeleton			NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|skin(1)	14		Breast(137;0.000301)|Ovarian(249;0.15)				TCTTTATATCTGAATTCATAT	0.303000													29	46					0	0	1	0	0
EIF4G3	8672	broad.mit.edu	37	1	21143902	21143902	+	Missense_Mutation	SNP	T	T	C			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr1:21143902T>C	ENST00000602326.1	-	32	4931	c.4348A>G	c.(4348-4350)Atc>Gtc	p.I1450V	EIF4G3_ENST00000374937.3_Missense_Mutation_p.I1450V|EIF4G3_ENST00000400422.1_Missense_Mutation_p.I1444V|EIF4G3_ENST00000264211.8_Missense_Mutation_p.I1444V|EIF4G3_ENST00000374935.3_Missense_Mutation_p.I1164V|EIF4G3_ENST00000536266.1_Missense_Mutation_p.I1048V|EIF4G3_ENST00000537738.1_Missense_Mutation_p.I934V	NM_001198802.1	NP_001185731.1	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4 gamma, 3	1444	EIF4A-binding (By similarity).|W2.				interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(18)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(1)|urinary_tract(3)	70		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		CAGTCAAAGATCTGTTCATCA	0.428000													45	43					0	0	1	0	0
ANXA2	302	broad.mit.edu	37	15	60641322	60641322	+	Missense_Mutation	SNP	C	C	A			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr15:60641322C>A	ENST00000396024.3	-	13	1071	c.912G>T	c.(910-912)agG>agT	p.R304S	ANXA2_ENST00000451270.2_Missense_Mutation_p.R304S|ANXA2_ENST00000332680.4_Missense_Mutation_p.R322S|ANXA2_ENST00000421017.2_Missense_Mutation_p.R304S	NM_001136015.2	NP_001129487.1	P07355	ANXA2_HUMAN	annexin A2	304					angiogenesis|positive regulation of vesicle fusion|skeletal system development	basement membrane|melanosome|midbody|soluble fraction	calcium ion binding|calcium-dependent phospholipid binding|cytoskeletal protein binding|phospholipase inhibitor activity			kidney(1)|large_intestine(2)|lung(3)|ovary(2)|prostate(1)	9					Alteplase(DB00009)|Anistreplase(DB00029)|Tenecteplase(DB00031)	TGAATTCAGACCTAATTTTCA	0.502000													14	57					3.27435e-08	3.35831e-08	1	1	0
SH3BP2	6452	broad.mit.edu	37	4	2831730	2831731	+	Frame_Shift_Ins	INS	-	-	C			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr4:2831730_2831731insC	ENST00000356331.5	+	8	1358_1359	c.1097_1098insC	c.(1096-1101)gaccccfs	p.DP366fs	SH3BP2_ENST00000452765.2_Frame_Shift_Ins_p.DP366fs|SH3BP2_ENST00000511747.1_Frame_Shift_Ins_p.DP366fs|SH3BP2_ENST00000435136.2_Frame_Shift_Ins_p.DP366fs|SH3BP2_ENST00000503393.2_Frame_Shift_Ins_p.DP423fs|SH3BP2_ENST00000442312.2_Frame_Shift_Ins_p.DP394fs	NM_003023.4	NP_003014.3	P78314	3BP2_HUMAN	SH3-domain binding protein 2	366					signal transduction		SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	20				UCEC - Uterine corpus endometrioid carcinoma (64;0.164)		GCTGAAGAGGACCCCCCAAGGG	0.658									Cherubism				115	33	---	---	---	---					
HMGB2	3148	broad.mit.edu	37	4	174253235	174253240	+	In_Frame_Del	DEL	TCTTCA	TCTTCA	-			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr4:174253235_174253240delTCTTCA	ENST00000296503.5	-	5	1494_1499	c.621_626delTGAAGA	c.(619-627)gatgaagaa>gaa	p.DE207del	HMGB2_ENST00000438704.2_In_Frame_Del_p.DE207del|HMGB2_ENST00000446922.2_In_Frame_Del_p.DE207del			P26583	HMGB2_HUMAN	high mobility group box 2	207	Asp/Glu-rich (acidic).				base-excision repair, DNA ligation|cell chemotaxis|cellular response to lipopolysaccharide|DNA fragmentation involved in apoptotic nuclear change|DNA topological change|negative regulation of transcription, DNA-dependent|nucleosome assembly|phosphatidylinositol-mediated signaling|positive regulation of DNA binding|positive regulation of endothelial cell proliferation|positive regulation of erythrocyte differentiation|positive regulation of megakaryocyte differentiation|positive regulation of nuclease activity|positive regulation of transcription from RNA polymerase II promoter|V(D)J recombination	condensed chromosome|extracellular space|nucleolus|nucleoplasm|perinuclear region of cytoplasm|protein complex	chemoattractant activity|damaged DNA binding|DNA bending activity|double-stranded DNA binding|RAGE receptor binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding|transcription regulatory region DNA binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|urinary_tract(3)	14		Prostate(90;0.0132)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_hematologic(60;0.107)|all_neural(102;0.122)		all cancers(43;9.58e-18)|Epithelial(43;3.75e-16)|OV - Ovarian serous cystadenocarcinoma(60;6.24e-09)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		AGCCATTTAttcttcatcttcatcct	0.442													59	112	---	---	---	---					
KCNN2	3781	broad.mit.edu	37	5	113698631	113698632	+	In_Frame_Ins	INS	-	-	GCC	rs34838882	by1000genomes	TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr5:113698631_113698632insGCC	ENST00000512097.3	+	2	1177_1178	c.159_160insGCC	c.(160-162)gcc>GCCgcc	p.54_54A>AA	KCNN2_ENST00000264773.3_In_Frame_Ins_p.54_54A>AA			Q9H2S1	KCNN2_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2	54	Poly-Ala.					integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		CTGCAGCCGCTGCCGCCGCCGC	0.703													3	3	---	---	---	---					
SNAPC4	6621	broad.mit.edu	37	9	139277995	139277997	+	In_Frame_Del	DEL	GCT	GCT	-	rs34222232		TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr9:139277995_139277997delGCT	ENST00000298532.2	-	15	1992_1994	c.1624_1626delAGC	c.(1624-1626)agcdel	p.S542del		NM_003086.2	NP_003077.2	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex, polypeptide 4, 190kDa	542					snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity	p.S542delS(2)		biliary_tract(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	33		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		CGTCCTCCTCgctgctgctgctg	0.690													2	4	---	---	---	---					
CEP290	80184	broad.mit.edu	37	12	88512304	88512305	+	Frame_Shift_Ins	INS	-	-	T	rs77980773		TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr12:88512304_88512305insT	ENST00000552810.1	-	17	2009_2010	c.1666_1667insA	c.(1666-1668)attfs	p.I556fs	CEP290_ENST00000397838.3_5'UTR|CEP290_ENST00000309041.7_Frame_Shift_Ins_p.I558fs	NM_025114.3	NP_079390.3	O15078	CE290_HUMAN	centrosomal protein 290kDa	556					cilium assembly|eye photoreceptor cell development|G2/M transition of mitotic cell cycle|hindbrain development|otic vesicle formation|positive regulation of transcription, DNA-dependent|pronephros development|protein transport	cell surface|centrosome|cytosol|nucleus|photoreceptor connecting cilium	protein binding	p.I558fs*20(1)		breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|liver(1)|lung(18)|ovary(5)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	73						CATTTGACGAATTTTTTTTTTC	0.312													3	6	---	---	---	---					
TUNAR	100507043	broad.mit.edu	37	14	96355806	96355808	+	RNA	DEL	CCT	CCT	-	rs2369329		TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr14:96355806_96355808delCCT	ENST00000503525.2	+	0	406					NR_038861.1																						tctccctccccctcctcctcctc	0.606													2	4	---	---	---	---					
DNM1P47	100216544	broad.mit.edu	37	15	102296030	102296032	+	RNA	DEL	CTC	CTC	-			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr15:102296030_102296032delCTC	ENST00000561463.1	+	0	4076_4078																											AGTTCATCTTCTCGGAGCTGCTG	0.596													5	3	---	---	---	---					
FBRS	64319	broad.mit.edu	37	16	30671164	30671166	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr16:30671164_30671166delGAG	ENST00000356166.6	+	1	1413_1415	c.325_327delGAG	c.(325-327)gagdel	p.E115del				Q9HAH7	FBRS_HUMAN	fibrosin	312										ovary(1)	1			Colorectal(24;0.103)			CGGggaggaagaggaggaggagg	0.734													5	5	---	---	---	---					
ANKFY1	51479	broad.mit.edu	37	17	4086731	4086732	+	Frame_Shift_Ins	INS	-	-	GC			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr17:4086731_4086732insGC	ENST00000341657.4	-	14	1948_1949	c.1913_1914insGC	c.(1912-1914)gcafs	p.A638fs	CYB5D2_ENST00000573984.1_Intron|ANKFY1_ENST00000570535.1_Frame_Shift_Ins_p.A680fs|ANKFY1_ENST00000574367.1_Frame_Shift_Ins_p.A638fs	NM_016376.3	NP_057460.3	Q9P2R3	ANFY1_HUMAN	ankyrin repeat and FYVE domain containing 1	638						endosome membrane	metal ion binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(11)|liver(1)|lung(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32						GCAGGAAGAGTGCGCTCTTGCT	0.550													60	101	---	---	---	---					
RP11-161I6.2	0	broad.mit.edu	37	18	2089466	2089466	+	RNA	DEL	A	A	-	rs58767171		TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr18:2089466delA	ENST00000579097.1	-	0	310																											CTGCCCCCCCACCCACTCACC	0.527													12	3	---	---	---	---					
CABLES1	91768	broad.mit.edu	37	18	20716015	20716023	+	In_Frame_Del	DEL	GGCGCCGGC	GGCGCCGGC	-			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr18:20716015_20716023delGGCGCCGGC	ENST00000256925.7	+	1	289_297	c.289_297delGGCGCCGGC	c.(289-297)ggcgccggcdel	p.GAG97del	CABLES1_ENST00000400473.2_Intron	NM_001100619.2	NP_001094089.1	Q8TDN4	CABL1_HUMAN	Cdk5 and Abl enzyme substrate 1	97	Ala-rich.|Interacts with TDRD7 (By similarity).				blood coagulation|cell cycle|cell division|regulation of cell cycle|regulation of cell division	cytosol|nucleus	cyclin-dependent protein kinase regulator activity|protein binding			breast(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|stomach(1)	11	all_cancers(21;0.000102)|all_epithelial(16;2.48e-06)|Lung NSC(20;0.00696)|all_lung(20;0.0197)|Colorectal(14;0.0202)|Ovarian(20;0.127)					ggccaagccgggcgccggcggcgcctgcg	0.785													4	2	---	---	---	---					
HPS4	89781	broad.mit.edu	37	22	26868322	26868322	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr22:26868322delG	ENST00000398145.2	-	6	1063	c.447delC	c.(445-447)aacfs	p.N149fs	HPS4_ENST00000402105.3_Frame_Shift_Del_p.N144fs|HPS4_ENST00000336873.5_Frame_Shift_Del_p.N149fs|HPS4_ENST00000398141.1_Frame_Shift_Del_p.N144fs	NM_022081.5	NP_071364.4	Q9NQG7	HPS4_HUMAN	Hermansky-Pudlak syndrome 4	149					lysosome organization|positive regulation of eye pigmentation|protein stabilization|protein targeting	lysosome|melanosome|membrane fraction|platelet dense granule	protein homodimerization activity			breast(2)|endometrium(3)|kidney(5)|large_intestine(4)|lung(12)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	32						GATCACTGGTGTTTTTCAGAA	0.393									Hermansky-Pudlak syndrome				68	104	---	---	---	---