Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CPD	1362	broad.mit.edu	37	17	28750013	28750013	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:28750013A>G	ENST00000225719.4	+	5	1705	c.1629A>G	c.(1627-1629)atA>atG	p.I543M	CPD_ENST00000543464.2_Missense_Mutation_p.I296M	NM_001304.4	NP_001295.2	O75976	CBPD_HUMAN	carboxypeptidase D	543	Carboxypeptidase-like 2.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(13)|skin(5)|stomach(1)|urinary_tract(1)	36						TGATGGAGATATCTGATAATC	0.383000													15	42					0	0	1	0	0
CEP95	90799	broad.mit.edu	37	17	62523291	62523291	+	Silent	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:62523291T>C	ENST00000556440.2	+	11	1725	c.1215T>C	c.(1213-1215)acT>acC	p.T405T	CEP95_ENST00000553412.1_Silent_p.T241T|CEP95_ENST00000577476.1_3'UTR	NM_138363.1	NP_612372.1	Q96GE4	CEP95_HUMAN	centrosomal protein 95kDa	405						centrosome|spindle pole	protein binding			endometrium(1)|kidney(3)|large_intestine(5)|lung(3)|ovary(1)	13						AAGAAAATACTGGAAATGAGG	0.413000													6	30					0	0	1	0	0
HDAC8	55869	broad.mit.edu	37	X	71792545	71792545	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chrX:71792545C>T	ENST00000439122.2	-	1	353	c.67G>A	c.(67-69)Gag>Aag	p.E23K	HDAC8_ENST00000373589.4_Missense_Mutation_p.E23K|HDAC8_ENST00000373561.4_Missense_Mutation_p.E23K|HDAC8_ENST00000373573.3_Missense_Mutation_p.E23K|HDAC8_ENST00000429103.2_5'UTR|HDAC8_ENST00000373571.1_Missense_Mutation_p.E23K|HDAC8_ENST00000373556.3_Missense_Mutation_p.E23K|HDAC8_ENST00000373560.2_Missense_Mutation_p.E23K|HDAC8_ENST00000373583.1_Missense_Mutation_p.E23K|HDAC8_ENST00000478743.1_5'UTR|HDAC8_ENST00000373554.1_Missense_Mutation_p.E23K|HDAC8_ENST00000373559.4_Missense_Mutation_p.E23K	NM_001166419.1	NP_001159891.1	Q9BY41	HDAC8_HUMAN	histone deacetylase 8	23	Histone deacetylase.				chromatin assembly or disassembly|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|nuclear chromosome	histone deacetylase activity (H3-K16 specific)|metal ion binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription factor binding			breast(3)|cervix(1)|endometrium(1)|lung(4)|prostate(1)	10	Renal(35;0.156)				Vorinostat(DB02546)	CTGACATACTCGGGACTATAG	0.592000													68	42					0	0	1	0	0
WDR33	55339	broad.mit.edu	37	2	128467402	128467402	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:128467402C>T	ENST00000322313.4	-	19	3495	c.3337G>A	c.(3337-3339)Gag>Aag	p.E1113K		NM_018383.4	NP_060853.3	Q9C0J8	WDR33_HUMAN	WD repeat domain 33	1113					postreplication repair|spermatogenesis	collagen|nucleus	protein binding			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		GCACGGCCCTCATGCCTCGGC	0.522000													73	130					0	0	1	0	0
FAM163B	642968	broad.mit.edu	37	9	136444273	136444273	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:136444273C>G	ENST00000496132.1	-	3	616	c.372G>C	c.(370-372)aaG>aaC	p.K124N	FAM163B_ENST00000356873.3_Missense_Mutation_p.K124N			P0C2L3	F163B_HUMAN	family with sequence similarity 163, member B	124						integral to membrane				large_intestine(1)	1						GGCTCACGCTCTTGTAGAGCA	0.711000													4	28					0	0	1	0	0
RRS1	23212	broad.mit.edu	37	8	67341274	67341274	+	Translation_Start_Site	SNP	T	T	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:67341274T>A	ENST00000320270.2	+	0	12					NM_015169.3	NP_055984.1	Q15050	RRS1_HUMAN	RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)						mitotic metaphase plate congression|ribosome biogenesis	condensed nuclear chromosome|nucleolus				kidney(2)|lung(2)	4		Lung NSC(129;0.197)	Epithelial(68;0.0391)|all cancers(69;0.0898)|BRCA - Breast invasive adenocarcinoma(89;0.111)|OV - Ovarian serous cystadenocarcinoma(28;0.226)			CATCCCGGCATCTGCACGTGG	0.627000											OREG0018806	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	13					0	0	1	0	0
SLCO1A2	6579	broad.mit.edu	37	12	21453473	21453473	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:21453473C>T	ENST00000307378.6	-	9	1439	c.719G>A	c.(718-720)cGt>cAt	p.R240H	SLCO1A2_ENST00000458504.1_Missense_Mutation_p.R108H|SLCO1A2_ENST00000537524.1_Missense_Mutation_p.R108H|SLCO1A2_ENST00000452078.1_Missense_Mutation_p.R240H|SLCO1A2_ENST00000390670.3_Missense_Mutation_p.R238H	NM_134431.3	NP_602307.1	P46721	SO1A2_HUMAN	solute carrier organic anion transporter family, member 1A2	240					bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(2)|endometrium(2)|kidney(4)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(6)|upper_aerodigestive_tract(1)	48						ACCGACCCAACGAGTGTCAGT	0.383000													3	25					0	0	1	0	0
KIAA0947	23379	broad.mit.edu	37	5	5464730	5464730	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:5464730C>T	ENST00000296564.7	+	13	5505	c.5283C>T	c.(5281-5283)gcC>gcT	p.A1761A		NM_015325.2	NP_056140.1	Q9Y2F5	K0947_HUMAN	KIAA0947	1761										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)	35						AGTTATCTGCCAGGGCCCGGA	0.547000													16	20					0	0	1	0	0
ARID3B	10620	broad.mit.edu	37	15	74836792	74836792	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:74836792G>C	ENST00000346246.5	+	2	746	c.515G>C	c.(514-516)gGa>gCa	p.G172A		NM_006465.2	NP_006456.1	Q8IVW6	ARI3B_HUMAN	AT rich interactive domain 3B (BRIGHT-like)	172					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(7)|prostate(2)	14						TCCACAGCAGGACAGCCGAAC	0.512000													25	37					0	0	1	0	0
PANX3	116337	broad.mit.edu	37	11	124489817	124489817	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:124489817G>C	ENST00000284288.2	+	4	1232	c.1165G>C	c.(1165-1167)Gat>Cat	p.D389H		NM_052959.2	NP_443191.1	Q96QZ0	PANX3_HUMAN	pannexin 3	389					protein hexamerization	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity			NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(10)|prostate(2)|skin(2)|urinary_tract(1)	26	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0219)		CTCGGCATGTGATGAACACCC	0.418000													34	47					0	0	1	0	0
MCAM	4162	broad.mit.edu	37	11	119181614	119181614	+	Splice_Site	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:119181614C>T	ENST00000264036.4	-	14	1660		c.e14-1		MCAM_ENST00000392814.1_3'UTR	NM_006500.2	NP_006491.2	P43121	MUC18_HUMAN	melanoma cell adhesion molecule						anatomical structure morphogenesis|cell adhesion	integral to membrane|plasma membrane				breast(2)|central_nervous_system(2)|endometrium(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(3)|skin(1)	22		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.78e-05)		AGCTTTCTCTCTGCGCCACAA	0.632000													34	182					0	0	1	0	0
LINS	55180	broad.mit.edu	37	15	101112154	101112154	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:101112154C>T	ENST00000314742.8	-	6	1561	c.1339G>A	c.(1339-1341)Gat>Aat	p.D447N		NM_001040616.2	NP_001035706	Q8NG48	LINES_HUMAN	lines homolog (Drosophila)	447								p.D447Y(1)		central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|prostate(1)|skin(1)|stomach(4)	21						AGCATGTCATCGTCTTGTTCT	0.448000													39	48					0	0	1	0	0
GRIK5	2901	broad.mit.edu	37	19	42558025	42558025	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:42558025G>A	ENST00000262895.3	-	9	1112	c.1113C>T	c.(1111-1113)acC>acT	p.T371T	GRIK5_ENST00000301218.4_Silent_p.T371T|GRIK5_ENST00000593562.1_Silent_p.T371T	NM_002088.4	NP_002079.3	Q16478	GRIK5_HUMAN	glutamate receptor, ionotropic, kainate 5	371						cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(11)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	35		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	GGGTGTAGTTGGTTCTCTGCC	0.662000													22	51					0	0	1	0	0
ARID5B	84159	broad.mit.edu	37	10	63852165	63852165	+	Silent	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:63852165G>C	ENST00000279873.7	+	10	3353	c.2943G>C	c.(2941-2943)gtG>gtC	p.V981V	ARID5B_ENST00000309334.5_Silent_p.V738V	NM_032199.2	NP_115575.1	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	981					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			NS(1)|breast(2)|endometrium(13)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	Prostate(12;0.016)|all_hematologic(501;0.215)					CTCACCATGTGAGACTGGAGA	0.537000													32	131					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	140878605	140878605	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:140878605G>A	ENST00000371372.1	+	13	1817	c.1672G>A	c.(1672-1674)Gtc>Atc	p.V558I	CACNA1B_ENST00000277549.5_5'UTR|CACNA1B_ENST00000371363.1_Missense_Mutation_p.V558I|CACNA1B_ENST00000371355.4_Missense_Mutation_p.V559I|CACNA1B_ENST00000277551.2_Missense_Mutation_p.V558I|CACNA1B_ENST00000371357.1_Missense_Mutation_p.V559I	NM_000718.3|NM_001243812.1	NP_000709.1|NP_001230741.1	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	558					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CGTGGGGAGCGTCTTTGAAGT	0.592000													4	8					0	0	1	0	0
FN1	2335	broad.mit.edu	37	2	216226285	216226285	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:216226285C>T	ENST00000354785.4	-	46	7796	c.7427G>A	c.(7426-7428)cGa>cAa	p.R2476Q	FN1_ENST00000357009.2_3'UTR|FN1_ENST00000421182.1_Missense_Mutation_p.R2239Q|FN1_ENST00000345488.5_Missense_Mutation_p.R2183Q|FN1_ENST00000357867.4_Missense_Mutation_p.R2175Q|FN1_ENST00000446046.1_Missense_Mutation_p.R2329Q|FN1_ENST00000443816.1_Missense_Mutation_p.R2264Q|FN1_ENST00000323926.6_Missense_Mutation_p.R2445Q|FN1_ENST00000432072.2_Missense_Mutation_p.R2266Q|FN1_ENST00000356005.4_Missense_Mutation_p.R2295Q|FN1_ENST00000359671.1_Missense_Mutation_p.R2385Q|FN1_ENST00000336916.4_Missense_Mutation_p.R2354Q|FN1_ENST00000346544.3_Missense_Mutation_p.R2210Q			P02751	FINC_HUMAN	fibronectin 1	2385					acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding		FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GATTTACTCTCGGGAATCTTC	0.408000													26	152					0	0	1	0	0
CSNK2A1	1457	broad.mit.edu	37	20	470507	470507	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:470507C>A	ENST00000217244.3	-	10	1015	c.640G>T	c.(640-642)Gat>Tat	p.D214Y	CSNK2A1_ENST00000400217.2_Missense_Mutation_p.D78Y|CSNK2A1_ENST00000400227.3_Missense_Mutation_p.D214Y|CSNK2A1_ENST00000349736.5_Missense_Mutation_p.D214Y	NM_177559.2	NP_808227.1	P68400	CSK21_HUMAN	casein kinase 2, alpha 1 polypeptide	214	Protein kinase.				axon guidance|Wnt receptor signaling pathway	cytosol|NuRD complex|plasma membrane|Sin3 complex	ATP binding|protein N-terminus binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|urinary_tract(1)	17		Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.0969)			CTCCACATATCCAAACTATAA	0.323000													21	51					3.62473e-10	3.77119e-10	1	1	0
ATP8B3	148229	broad.mit.edu	37	19	1784889	1784889	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:1784889C>T	ENST00000539485.1	-	28	3852	c.3619G>A	c.(3619-3621)Gtg>Atg	p.V1207M	ATP8B3_ENST00000310127.6_Missense_Mutation_p.V1197M|ATP8B3_ENST00000525591.1_Missense_Mutation_p.V1160M			O60423	AT8B3_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 3	1197					ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	23		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTTATGGACACACTCAGCAGG	0.637000													6	33					0	0	1	0	0
NFYA	4800	broad.mit.edu	37	6	41057404	41057404	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:41057404C>T	ENST00000341376.6	+	5	597	c.396C>T	c.(394-396)atC>atT	p.I132I	NFYA_ENST00000353205.5_Silent_p.I103I|OARD1_ENST00000480585.1_Intron	NM_002505.4	NP_002496.1	P23511	NFYA_HUMAN	nuclear transcription factor Y, alpha	132	Gln-rich.				transcription from RNA polymerase II promoter	CCAAT-binding factor complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(2)|urinary_tract(1)	9	Ovarian(28;0.0418)|Colorectal(47;0.196)					CCCAGCAGATCATCATCCAGC	0.552000													54	75					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77743847	77743847	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:77743847C>T	ENST00000407578.2	-	39	6063	c.5797G>A	c.(5797-5799)Gat>Aat	p.D1933N	MYCBP2_ENST00000544440.2_Missense_Mutation_p.D1895N|MYCBP2_ENST00000360084.5_5'UTR|MYCBP2_ENST00000357337.6_Missense_Mutation_p.D1895N	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	1895					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		GGAATGTCATCAGCTAAAAAA	0.398000													20	34					0	0	1	0	0
HSD3B2	3284	broad.mit.edu	37	1	119958115	119958115	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:119958115G>C	ENST00000543831.1	+	2	322	c.73G>C	c.(73-75)Gag>Cag	p.E25Q	HSD3B2_ENST00000369416.3_Missense_Mutation_p.E25Q|HSD3B2_ENST00000471656.1_3'UTR	NM_001166120.1	NP_001159592.1	P26439	3BHS2_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	25					androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(19)|ovary(2)|skin(1)	27	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	GTTGGTGGAAGAGAAGGAACT	0.522000													18	73					0	0	1	0	0
AMOT	154796	broad.mit.edu	37	X	112033995	112033995	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chrX:112033995G>A	ENST00000371959.3	-	7	1941	c.1942C>T	c.(1942-1944)Cag>Tag	p.Q648*	AMOT_ENST00000371958.1_Nonsense_Mutation_p.Q416*|AMOT_ENST00000371962.1_Nonsense_Mutation_p.Q416*|AMOT_ENST00000524145.1_Nonsense_Mutation_p.Q648*|AMOT_ENST00000304758.1_Nonsense_Mutation_p.Q239*	NM_001113490.1	NP_001106962.1	Q4VCS5	AMOT_HUMAN	angiomotin	648					actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction	angiostatin binding|protein binding|receptor activity	p.Q239*(1)|p.Q648*(1)		breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	43						TTGGTGGGCTGACAGTTGCCC	0.512000													39	29					0	0	1	0	0
CYP1A2	1544	broad.mit.edu	37	15	75043585	75043585	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:75043585G>C	ENST00000343932.4	+	3	950	c.887G>C	c.(886-888)aGa>aCa	p.R296T		NM_000761.3	NP_000752.2	P05177	CP1A2_HUMAN	cytochrome P450, family 1, subfamily A, polypeptide 2	296					alkaloid metabolic process|exogenous drug catabolic process|methylation|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative deethylation|oxidative demethylation|steroid catabolic process|toxin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|demethylase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(7)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	33					Acenocoumarol(DB01418)|Acetaminophen(DB00316)|Aciclovir(DB00787)|Alosetron(DB00969)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Anagrelide(DB00261)|Azelastine(DB00972)|Bortezomib(DB00188)|Caffeine(DB00201)|Carmustine(DB00262)|Chlordiazepoxide(DB00475)|Chlorpromazine(DB00477)|Chlorzoxazone(DB00356)|Cimetidine(DB00501)|Cinacalcet(DB01012)|Ciprofloxacin(DB00537)|Clomipramine(DB01242)|Clotrimazole(DB00257)|Clozapine(DB00363)|Conjugated Estrogens(DB00286)|Cyclobenzaprine(DB00924)|Dacarbazine(DB00851)|Desloratadine(DB00967)|Diazepam(DB00829)|Dibucaine(DB00527)|Diclofenac(DB00586)|Duloxetine(DB00476)|Enoxacin(DB00467)|Esomeprazole(DB00736)|Estradiol(DB00783)|Estrone(DB00655)|Fluorouracil(DB00544)|Flutamide(DB00499)|Fluvoxamine(DB00176)|Frovatriptan(DB00998)|Grepafloxacin(DB00365)|Haloperidol(DB00502)|Hesperetin(DB01094)|Imipramine(DB00458)|Ketoconazole(DB01026)|Leflunomide(DB01097)|Levobupivacaine(DB01002)|Levofloxacin(DB01137)|Lidocaine(DB00281)|Lomefloxacin(DB00978)|Melatonin(DB01065)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mirtazapine(DB00370)|Norfloxacin(DB01059)|Nortriptyline(DB00540)|Ofloxacin(DB01165)|Olanzapine(DB00334)|Ondansetron(DB00904)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Pefloxacin(DB00487)|Pimozide(DB01100)|Propafenone(DB01182)|Propranolol(DB00571)|Quinidine(DB00908)|Ramelteon(DB00980)|Ranitidine(DB00863)|Rasagiline(DB01367)|Rifampin(DB01045)|Riluzole(DB00740)|Rofecoxib(DB00533)|Ropinirole(DB00268)|Ropivacaine(DB00296)|Tacrine(DB00382)|Telithromycin(DB00976)|Terfenadine(DB00342)|Theophylline(DB00277)|Thiabendazole(DB00730)|Tizanidine(DB00697)|Tolbutamide(DB01124)|Verapamil(DB00661)|Warfarin(DB00682)|Zileuton(DB00744)|Zolmitriptan(DB00315)	AAGGGGCCTAGAGCCAGCGGC	0.557000													40	61					0	0	1	0	0
CEBPE	1053	broad.mit.edu	37	14	23588121	23588121	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:23588121C>T	ENST00000206513.5	-	1	704	c.180G>A	c.(178-180)gtG>gtA	p.V60V		NM_001805.3	NP_001796.2	Q15744	CEBPE_HUMAN	CCAAT/enhancer binding protein (C/EBP), epsilon	60						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(2)|lung(3)|ovary(2)|prostate(1)|skin(1)	9	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0064)		GCGCTGGCTTCACGGCAAAGA	0.632000													33	62					0	0	1	0	0
ALG1L	200810	broad.mit.edu	37	3	125652507	125652507	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:125652507G>A	ENST00000340333.3	-	2	174	c.11C>T	c.(10-12)tCg>tTg	p.S4L		NM_001015050.2|NM_001195223.1	NP_001015050.2|NP_001182152.1	Q6GMV1	ALG1L_HUMAN	ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase-like	4							transferase activity, transferring glycosyl groups			large_intestine(2)|lung(2)	4						CATGAAGGCCGACCGCTCCAT	0.637000													13	46					0	0	1	0	0
XKR7	343702	broad.mit.edu	37	20	30584822	30584822	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:30584822C>T	ENST00000562532.2	+	3	1476	c.1302C>T	c.(1300-1302)gtC>gtT	p.V434V		NM_001011718.1	NP_001011718.1	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related family, member 7							integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(19)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	34			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			TCATGTGTGTCTACTACTGTC	0.587000													25	103					0	0	1	0	0
ARHGEF17	9828	broad.mit.edu	37	11	73066682	73066682	+	Silent	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:73066682C>G	ENST00000263674.3	+	4	3908	c.3558C>G	c.(3556-3558)ctC>ctG	p.L1186L		NM_014786.3	NP_055601.2	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1186	DH.				actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|skin(2)	32						CTGCCTTTCTCAAGTTCCTAG	0.557000													34	88					0	0	1	0	0
ZNF217	7764	broad.mit.edu	37	20	52199147	52199147	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:52199147G>A	ENST00000371471.2	-	2	644	c.219C>T	c.(217-219)acC>acT	p.T73T	ZNF217_ENST00000302342.3_Silent_p.T73T			O75362	ZN217_HUMAN	zinc finger protein 217	73					negative regulation of transcription, DNA-dependent	histone deacetylase complex	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(17)|ovary(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	50	all_cancers(1;6.75e-17)|all_epithelial(1;1.76e-18)|Breast(2;3.83e-14)|Lung NSC(4;9.04e-07)|all_lung(4;2.5e-06)|Ovarian(1;0.0398)		BRCA - Breast invasive adenocarcinoma(1;9.88e-17)|Epithelial(1;1.56e-14)|all cancers(1;9.44e-13)|STAD - Stomach adenocarcinoma(23;0.0474)|Colorectal(105;0.198)			AATGTGTGAAGGTCTGGCTGC	0.463000													42	96					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133531409	133531409	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:133531409A>G	ENST00000409261.1	-	16	5481	c.5108T>C	c.(5107-5109)gTa>gCa	p.V1703A	NCKAP5_ENST00000405974.3_Missense_Mutation_p.V384A|NCKAP5_ENST00000409213.1_Missense_Mutation_p.V384A|NCKAP5_ENST00000317721.6_Missense_Mutation_p.V1703A|NCKAP5_ENST00000473859.1_Intron	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	1703							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						GCTCTGAAATACAGAATCTGC	0.343000													40	67					0	0	1	0	0
AJUBA	84962	broad.mit.edu	37	14	23444283	23444283	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:23444283G>T	ENST00000262713.2	-	5	1645	c.1270C>A	c.(1270-1272)Cca>Aca	p.P424T	AJUBA_ENST00000397388.3_Missense_Mutation_p.P7T|RP11-298I3.5_ENST00000555074.1_Intron|AJUBA_ENST00000361265.4_Missense_Mutation_p.P424T	NM_032876.4	NP_116265.1	Q96IF1	JUB_HUMAN	ajuba LIM protein	424	LIM zinc-binding 2.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding										AAACAGCCTGGATGATAGGAC	0.517000													29	103					1.06801e-11	1.12087e-11	1	1	0
STAC3	246329	broad.mit.edu	37	12	57638146	57638146	+	Silent	SNP	T	T	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:57638146T>A	ENST00000332782.2	-	10	1011	c.810A>T	c.(808-810)ccA>ccT	p.P270P	STAC3_ENST00000554578.1_Silent_p.P231P|STAC3_ENST00000546246.2_Silent_p.P84P	NM_145064.1	NP_659501.1	Q96MF2	STAC3_HUMAN	SH3 and cysteine rich domain 3	270	SH3 1.				intracellular signal transduction		identical protein binding|metal ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(10)|ovary(2)|skin(1)	18						TCTTCTCTCCTGGCCTGGGAG	0.587000											OREG0021942	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	71					0	0	1	0	0
APPL1	26060	broad.mit.edu	37	3	57282256	57282256	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:57282256T>C	ENST00000288266.3	+	10	887	c.740T>C	c.(739-741)aTg>aCg	p.M247T		NM_012096.2	NP_036228.1	Q9UKG1	DP13A_HUMAN	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	247	Required for RAB5A binding.				apoptosis|cell cycle|cell proliferation|insulin receptor signaling pathway|regulation of apoptosis|regulation of establishment of protein localization in plasma membrane|regulation of glucose import	cytosol|early endosome membrane|microsome|nucleus|vesicle membrane	protein kinase B binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(10)|liver(2)|lung(4)|prostate(2)	27				KIRC - Kidney renal clear cell carcinoma(284;0.0124)|Kidney(284;0.0144)		ATAGAGACCATGCAACAGACA	0.408000													25	88					0	0	1	0	0
FAM160B1	57700	broad.mit.edu	37	10	116621198	116621198	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:116621198G>A	ENST00000369248.4	+	17	2532	c.2197G>A	c.(2197-2199)Gac>Aac	p.D733N	FAM160B1_ENST00000369250.3_Intron	NM_020940.3	NP_065991.3	Q5W0V3	F16B1_HUMAN	family with sequence similarity 160, member B1	733										NS(1)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(5)|lung(13)	25						TACCAGTATTGACCACATCAC	0.368000													24	23					0	0	1	0	0
CHST11	50515	broad.mit.edu	37	12	105151459	105151459	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:105151459G>A	ENST00000303694.5	+	3	1376	c.937G>A	c.(937-939)Gaa>Aaa	p.E313K	CHST11_ENST00000549260.1_Missense_Mutation_p.E308K	NM_018413.5	NP_060883.1	Q9NPF2	CHSTB_HUMAN	carbohydrate (chondroitin 4) sulfotransferase 11	313					chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity			breast(2)|endometrium(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(1)	18						AACTACTGATGAAATGACCAC	0.463000													12	30					0	0	1	0	0
CCDC129	223075	broad.mit.edu	37	7	31682389	31682389	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:31682389C>T	ENST00000319386.3	+	11	1954	c.961C>T	c.(961-963)Cag>Tag	p.Q321*	CCDC129_ENST00000407970.3_Nonsense_Mutation_p.Q469*|CCDC129_ENST00000409210.1_Nonsense_Mutation_p.Q377*|CCDC129_ENST00000451887.2_Nonsense_Mutation_p.Q495*			Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	469										cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(31)	44						CCAGGACTGTCAGCTAGAGTC	0.502000													11	107					0	0	1	0	0
FOXC1	2296	broad.mit.edu	37	6	1612341	1612341	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:1612341G>A	ENST00000380874.2	+	1	1661	c.1661G>A	c.(1660-1662)tGa>tAa	p.*554*		NM_001453.2	NP_001444.2	Q12948	FOXC1_HUMAN	forkhead box C1	0					anti-apoptosis|artery morphogenesis|blood vessel remodeling|brain development|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|germ cell migration|glycosaminoglycan metabolic process|lacrimal gland development|lymphangiogenesis|metanephros development|negative regulation of mitotic cell cycle|neural crest cell fate commitment|Notch signaling pathway|odontogenesis of dentine-containing tooth|ossification|ovarian follicle development|paraxial mesodermal cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|ureteric bud development|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	nuclear heterochromatin|transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	8	Ovarian(93;0.0733)	all_cancers(2;4.45e-07)|all_epithelial(2;4.33e-05)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		Epithelial(2;0.0904)|OV - Ovarian serous cystadenocarcinoma(45;0.095)|all cancers(2;0.168)		AGCAAGTTTTGACACACCCTC	0.448000													18	86					0	0	1	0	0
PLA2G7	7941	broad.mit.edu	37	6	46678299	46678299	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:46678299C>T	ENST00000274793.7	-	8	956	c.760G>A	c.(760-762)Gat>Aat	p.D254N	PLA2G7_ENST00000541026.1_Missense_Mutation_p.D127N|PLA2G7_ENST00000538237.1_Missense_Mutation_p.D209N|PLA2G7_ENST00000537365.1_Missense_Mutation_p.D254N	NM_005084.3	NP_005075.3	Q13093	PAFA_HUMAN	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	254					inflammatory response|lipid catabolic process	extracellular space	1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding			endometrium(1)|kidney(1)|large_intestine(5)|lung(5)|skin(1)|soft_tissue(1)	14			Lung(136;0.192)			TGTTCCATATCAAACTTTAAA	0.333000													43	37					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	125834468	125834468	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:125834468C>T	ENST00000299308.3	+	2	531	c.523C>T	c.(523-525)Cgg>Tgg	p.R175W	TMEM132B_ENST00000418253.2_3'UTR	NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	175						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		AGCCAGCTGTCGGCTGCAAGG	0.612000													35	49					0	0	1	0	0
LPPR1	54886	broad.mit.edu	37	9	104032211	104032211	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:104032211C>A	ENST00000374874.3	+	3	552	c.113C>A	c.(112-114)aCt>aAt	p.T38N	LPPR1_ENST00000395056.2_Missense_Mutation_p.T38N	NM_207299.1	NP_997182.1	Q8TBJ4	LPPR1_HUMAN		38						integral to membrane	catalytic activity										TTCGAATGCACTGACACTTTT	0.502000													18	70					5.03518e-11	5.26904e-11	1	1	0
KMT2C	58508	broad.mit.edu	37	7	151896487	151896487	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:151896487C>T	ENST00000355193.2	-	27	4368	c.4150G>A	c.(4150-4152)Gat>Aat	p.D1384N	KMT2C_ENST00000262189.6_Missense_Mutation_p.D1384N					lysine (K)-specific methyltransferase 2C																		GACAGATTATCTAAACTTATC	0.348000													16	13					0	0	1	0	0
RHOB	388	broad.mit.edu	37	2	20647266	20647266	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:20647266G>A	ENST00000272233.4	+	1	432	c.40G>A	c.(40-42)Ggc>Agc	p.G14S		NM_004040.2	NP_004031.1	P62745	RHOB_HUMAN	ras homolog family member B	14					angiogenesis|axon guidance|cell adhesion|endosome to lysosome transport|negative regulation of cell cycle|platelet activation|positive regulation of angiogenesis|protein transport|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|transformed cell apoptosis	cytosol|late endosome membrane|nucleus|plasma membrane	GTP binding|GTPase activity|protein binding			breast(1)|kidney(1)|lung(2)|ovary(1)|urinary_tract(2)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)	all_epithelial(98;4.19e-09)|Lung NSC(108;0.00452)|Ovarian(717;0.0164)		OV - Ovarian serous cystadenocarcinoma(76;1.14e-22)|Epithelial(75;7.84e-19)		GGTGGGCGACGGCGCGTGTGG	0.677000													28	72					0	0	1	0	0
FADS1	3992	broad.mit.edu	37	11	61580784	61580784	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:61580784C>T	ENST00000350997.7	-	2	649	c.417G>A	c.(415-417)aaG>aaA	p.K139K	FADS1_ENST00000542506.1_5'UTR|FADS2_ENST00000574708.1_Intron|FADS1_ENST00000433932.1_5'UTR	NM_013402.4	NP_037534.3	O60427	FADS1_HUMAN	fatty acid desaturase 1	82					cell-cell signaling|cellular response to starvation|electron transport chain|icosanoid biosynthetic process|phospholipid biosynthetic process|regulation of cell differentiation|regulation of transcription, DNA-dependent|transport	endoplasmic reticulum membrane|integral to membrane|microsome	C-5 sterol desaturase activity|heme binding|protein binding			central_nervous_system(1)|endometrium(1)|lung(1)|urinary_tract(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	TCATATACTTCTTCACAAGGC	0.532000													103	154					0	0	1	0	0
RETN	56729	broad.mit.edu	37	19	7734744	7734744	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:7734744G>A	ENST00000221515.2	+	3	244	c.156G>A	c.(154-156)caG>caA	p.Q52Q	RETN_ENST00000381324.2_Intron	NM_001193374.1|NM_020415.3	NP_001180303.1|NP_065148.1	Q9HD89	RETN_HUMAN	resistin	52							hormone activity			ovary(1)	1						TGGAGTGCCAGAGCGTCACCT	0.612000													28	41					0	0	1	0	0
UNC45B	146862	broad.mit.edu	37	17	33482390	33482390	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:33482390C>T	ENST00000268876.5	+	7	812	c.715C>T	c.(715-717)Ctg>Ttg	p.L239L	UNC45B_ENST00000433649.1_Silent_p.L239L|UNC45B_ENST00000394570.2_Silent_p.L239L|UNC45B_ENST00000591048.1_Silent_p.L239L|UNC45B_ENST00000378449.1_Silent_p.L239L	NM_173167.2	NP_775259.1	Q8IWX7	UN45B_HUMAN	unc-45 homolog B (C. elegans)	239					cell differentiation|muscle organ development	cytosol	binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(10)|lung(24)|ovary(3)|prostate(2)|skin(1)|stomach(1)|urinary_tract(3)	59		Ovarian(249;0.17)				GGAGATGTCTCTGGCTGTCTG	0.557000													40	72					0	0	1	0	0
SLC38A8	146167	broad.mit.edu	37	16	84075602	84075602	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:84075602C>T	ENST00000299709.3	-	1	160	c.161G>A	c.(160-162)gGa>gAa	p.G54E		NM_001080442.1	NP_001073911.1	A6NNN8	S38A8_HUMAN	solute carrier family 38, member 8	54					amino acid transport|sodium ion transport	integral to membrane				central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	26						AGGGACCACTCCGCCCGCTTT	0.637000													18	174					0	0	1	0	0
DNTTIP1	116092	broad.mit.edu	37	20	44420659	44420659	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:44420659G>A	ENST00000372622.3	+	1	84	c.16G>A	c.(16-18)Gac>Aac	p.D6N		NM_052951.2	NP_443183.1	Q9H147	TDIF1_HUMAN	deoxynucleotidyltransferase, terminal, interacting protein 1	6						nucleus				breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(2)|prostate(1)	9		Myeloproliferative disorder(115;0.0122)				AGCCACTGGCGACGCCGAGCA	0.741000													35	25					0	0	1	0	0
EPB41L3	23136	broad.mit.edu	37	18	5438071	5438071	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr18:5438071G>C	ENST00000341928.2	-	6	908	c.568C>G	c.(568-570)Cca>Gca	p.P190A	EPB41L3_ENST00000540638.2_Missense_Mutation_p.P190A|EPB41L3_ENST00000342933.3_Missense_Mutation_p.P190A|EPB41L3_ENST00000544123.1_Missense_Mutation_p.P190A|EPB41L3_ENST00000542652.2_Intron|EPB41L3_ENST00000400111.3_Missense_Mutation_p.P190A	NM_012307.2	NP_036439.2	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	190	FERM.				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(52)|ovary(5)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	105						GGGTCTGGTGGATAAAATTTC	0.383000													15	49					0	0	1	0	0
SEC63	11231	broad.mit.edu	37	6	108202384	108202384	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:108202384G>T	ENST00000369002.4	-	18	2083	c.1904C>A	c.(1903-1905)aCa>aAa	p.T635K		NM_007214.4	NP_009145.1	Q9UGP8	SEC63_HUMAN	SEC63 homolog (S. cerevisiae)	635					protein folding|protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|receptor activity|unfolded protein binding			endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		all_cancers(87;5.35e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00225)|Colorectal(196;0.0294)		BRCA - Breast invasive adenocarcinoma(108;0.0079)|Epithelial(106;0.0356)|all cancers(137;0.0525)|OV - Ovarian serous cystadenocarcinoma(136;0.054)		CACAGGATGTGTTATTTTTGA	0.348000													28	46					8.88839e-20	9.49412e-20	1	1	0
RNMTL1	55178	broad.mit.edu	37	17	691281	691281	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:691281G>C	ENST00000304478.4	+	3	742	c.636G>C	c.(634-636)ttG>ttC	p.L212F		NM_018146.2	NP_060616.1	Q9HC36	RMTL1_HUMAN	RNA methyltransferase like 1	212					RNA processing		protein binding|RNA binding|RNA methyltransferase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	10				UCEC - Uterine corpus endometrioid carcinoma (25;0.0219)		CTTTATTATTGATTTGTGACA	0.463000													62	140					0	0	1	0	0
LAMB4	22798	broad.mit.edu	37	7	107746973	107746973	+	Silent	SNP	A	A	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:107746973A>C	ENST00000388781.3	-	7	719	c.636T>G	c.(634-636)ccT>ccG	p.P212P	LAMB4_ENST00000414450.2_Silent_p.P212P|LAMB4_ENST00000205386.4_Silent_p.P212P|LAMB4_ENST00000418464.1_Silent_p.P212P|LAMB4_ENST00000388780.3_Silent_p.P212P	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	212	Laminin N-terminal.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						AGGGGCTATAAGGGTTTTCAA	0.274000													11	7					0	0	1	0	0
GRB2	2885	broad.mit.edu	37	17	73316530	73316530	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:73316530G>C	ENST00000578961.1	-	4	578	c.404C>G	c.(403-405)cCa>cGa	p.P135R	GRB2_ENST00000316615.5_Silent_p.P150P|GRB2_ENST00000392563.1_Silent_p.P150P|GRB2_ENST00000392564.1_Silent_p.P191P|GRB2_ENST00000392562.1_Silent_p.P191P|GRB2_ENST00000316804.5_Silent_p.P191P|GRB2_ENST00000462266.1_5'UTR			P62993	GRB2_HUMAN	growth factor receptor-bound protein 2	0	SH2.				axon guidance|blood coagulation|cell junction assembly|cell-cell signaling|cellular response to ionizing radiation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|receptor internalization|signal transduction in response to DNA damage|T cell costimulation	cytosol|Golgi apparatus	epidermal growth factor receptor binding|insulin receptor substrate binding|SH3/SH2 adaptor activity			breast(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(3)|skin(1)	17	all_cancers(13;5.44e-09)|all_epithelial(9;1.1e-09)|Breast(9;1.85e-09)|all_lung(278;0.222)		all cancers(21;1.09e-07)|Epithelial(20;1.23e-06)|Lung(188;0.185)		Pegademase bovine(DB00061)	TCCACCAGTTGGGGTCTGAGT	0.537000													56	196					0	0	1	0	0
C16orf58	64755	broad.mit.edu	37	16	31502227	31502227	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:31502227C>T	ENST00000327237.2	-	13	1375	c.1336G>A	c.(1336-1338)Gag>Aag	p.E446K	C16orf58_ENST00000567994.1_Missense_Mutation_p.E401K|C16orf58_ENST00000570164.1_Missense_Mutation_p.E444K			Q96GQ5	CP058_HUMAN	chromosome 16 open reading frame 58	446						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)	14						TGGTGCTTCTCGGTCTTCCAG	0.627000													15	75					0	0	1	0	0
SLC25A36	55186	broad.mit.edu	37	3	140675471	140675471	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:140675471G>A	ENST00000446041.2	+	2	369	c.144G>A	c.(142-144)ctG>ctA	p.L48L	SLC25A36_ENST00000453248.2_Silent_p.L48L|SLC25A36_ENST00000507429.1_Silent_p.L48L|SLC25A36_ENST00000324194.6_Silent_p.L48L|SLC25A36_ENST00000393015.4_3'UTR	NM_001104647.1|NM_018155.2	NP_001098117.1|NP_060625.2	Q96CQ1	S2536_HUMAN	solute carrier family 25 (pyrimidine nucleotide carrier ), member 36	48					response to estradiol stimulus|transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			endometrium(2)|large_intestine(2)|lung(1)|upper_aerodigestive_tract(1)	6						AAGTTCAGCTGAACACCATGG	0.453000													22	133					0	0	1	0	0
PCDH19	57526	broad.mit.edu	37	X	99661763	99661763	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chrX:99661763G>A	ENST00000373034.4	-	1	3508	c.1833C>T	c.(1831-1833)gaC>gaT	p.D611D	PCDH19_ENST00000420881.2_Silent_p.D611D|PCDH19_ENST00000255531.7_Silent_p.D611D	NM_001184880.1	NP_001171809.1	Q8TAB3	PCD19_HUMAN	protocadherin 19	611	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(5)|endometrium(11)|kidney(1)|large_intestine(14)|liver(1)|lung(23)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	68						AGAAGCCGCGGTCGCCCTCGG	0.567000													8	58					0	0	1	0	0
TAB2	23118	broad.mit.edu	37	6	149699347	149699347	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:149699347G>T	ENST00000367456.1	+	4	873	c.296G>T	c.(295-297)gGa>gTa	p.G99V	TAB2_ENST00000538427.1_Missense_Mutation_p.G99V|TAB2_ENST00000286332.5_Missense_Mutation_p.G99V|TAB2_ENST00000536230.1_Missense_Mutation_p.G67V|TAB2_ENST00000392282.1_Missense_Mutation_p.G99V			Q9NYJ8	TAB2_HUMAN	TGF-beta activated kinase 1/MAP3K7 binding protein 2	99					activation of MAPK activity|heart development|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	K63-linked polyubiquitin binding|zinc ion binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|urinary_tract(1)	22						AGGATGAATGGAAGTAGGACT	0.453000													7	67					0.000274275	0.000279311	1	1	0
C3orf36	80111	broad.mit.edu	37	3	133647173	133647173	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:133647173C>G	ENST00000408895.2	-	1	1483	c.475G>C	c.(475-477)Ggc>Cgc	p.G159R		NM_025041.2	NP_079317.2	Q3SXR2	CC036_HUMAN	chromosome 3 open reading frame 36	159										breast(1)|endometrium(1)|large_intestine(2)|lung(1)|ovary(1)	6						CCCGCTCTGCCTTGAGACTGA	0.517000													16	83					0	0	1	0	0
TRUB1	142940	broad.mit.edu	37	10	116734976	116734976	+	Silent	SNP	A	A	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:116734976A>T	ENST00000298746.3	+	8	949	c.888A>T	c.(886-888)acA>acT	p.T296T		NM_139169.4	NP_631908.1	Q8WWH5	TRUB1_HUMAN	TruB pseudouridine (psi) synthase family member 1	296					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(2)|kidney(2)|large_intestine(1)|lung(5)|urinary_tract(2)	12		Colorectal(252;0.09)|Breast(234;0.174)|Lung NSC(174;0.245)		Epithelial(162;0.00879)|all cancers(201;0.0243)		ACAAATGGACAATTGATGACA	0.433000													69	69					0	0	1	0	0
SLC7A14	57709	broad.mit.edu	37	3	170198742	170198742	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:170198742G>A	ENST00000231706.5	-	7	1644	c.1329C>T	c.(1327-1329)ttC>ttT	p.F443F	CLDN11_ENST00000486975.1_Intron|CLDN11_ENST00000451576.1_Intron	NM_020949.2	NP_066000.2	Q8TBB6	S7A14_HUMAN	solute carrier family 7, member 14							integral to membrane	amino acid transmembrane transporter activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(23)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(4)	53	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			CCTCAGACAAGAACTTGACAA	0.512000													49	55					0	0	1	0	0
NVL	4931	broad.mit.edu	37	1	224477270	224477270	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:224477270C>T	ENST00000281701.6	-	13	1750	c.1491G>A	c.(1489-1491)caG>caA	p.Q497Q	NVL_ENST00000361463.3_Silent_p.Q391Q|NVL_ENST00000340871.4_Silent_p.Q308Q|NVL_ENST00000469075.1_Silent_p.Q406Q|NVL_ENST00000482491.1_Silent_p.Q221Q|NVL_ENST00000391875.2_Silent_p.Q391Q	NM_002533.3	NP_002524.2	O15381	NVL_HUMAN	nuclear VCP-like	497						aggresome|cytoplasm|nucleolus	ATP binding|nucleoside-triphosphatase activity			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(13)|ovary(1)|prostate(1)|skin(4)|soft_tissue(1)|urinary_tract(1)	42				GBM - Glioblastoma multiforme(131;0.00501)		GATTTTTCTTCTGCTGTTCCT	0.473000													23	35					0	0	1	0	0
VPS16	64601	broad.mit.edu	37	20	2844876	2844876	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:2844876A>G	ENST00000380445.3	+	17	1735	c.1663A>G	c.(1663-1665)Atg>Gtg	p.M555V	VPS16_ENST00000380443.3_Missense_Mutation_p.M241V|VPS16_ENST00000481812.2_3'UTR|VPS16_ENST00000380469.3_Missense_Mutation_p.M411V|PTPRA_ENST00000380393.3_5'UTR	NM_022575.2	NP_072097.2	Q9H269	VPS16_HUMAN	vacuolar protein sorting 16 homolog (S. cerevisiae)	555					intracellular protein transport	early endosome|HOPS complex|late endosome membrane|lysosomal membrane|recycling endosome				NS(3)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	37						TCTCCTAAAGATGAAGAGGAG	0.617000													26	86					0	0	1	0	0
ALDH3A1	218	broad.mit.edu	37	17	19648427	19648427	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:19648427C>T	ENST00000457500.2	-	1	345	c.16G>A	c.(16-18)Gag>Aag	p.E6K	ALDH3A1_ENST00000225740.6_Missense_Mutation_p.E6K|ALDH3A1_ENST00000485231.1_Intron|ALDH3A1_ENST00000444455.1_Missense_Mutation_p.E6K|ALDH3A1_ENST00000395555.3_Missense_Mutation_p.E6K|ALDH3A1_ENST00000494157.2_Intron	NM_001135168.1	NP_001128640.1	P30838	AL3A1_HUMAN	aldehyde dehydrogenase 3 family, member A1	6					cellular aldehyde metabolic process	cytosol|endoplasmic reticulum	alcohol dehydrogenase (NADP+) activity|aldehyde dehydrogenase|aldehyde dehydrogenase (NAD) activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|urinary_tract(1)	13	all_cancers(12;4.01e-05)|all_epithelial(12;0.00301)|Breast(13;0.186)			Colorectal(15;0.0829)	NADH(DB00157)	TTCACGGCCTCGCTGATCTTG	0.682000													18	38					0	0	1	0	0
STOX1	219736	broad.mit.edu	37	10	70645249	70645249	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:70645249T>C	ENST00000298596.6	+	3	1780	c.1697T>C	c.(1696-1698)aTa>aCa	p.I566T	STOX1_ENST00000399169.4_Missense_Mutation_p.I566T|STOX1_ENST00000399165.4_Intron|STOX1_ENST00000399162.2_Intron|STOX1_ENST00000421961.2_Missense_Mutation_p.I456T	NM_152709.4	NP_689922.3	Q6ZVD7	STOX1_HUMAN	storkhead box 1	566						cytoplasm|nucleolus	DNA binding			breast(5)|endometrium(2)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|prostate(1)|skin(3)	28						TCCATTTACATAAATGACCCT	0.418000													14	62					0	0	1	0	0
COPS2	9318	broad.mit.edu	37	15	49431772	49431772	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:49431772C>G	ENST00000388901.5	-	4	398	c.325G>C	c.(325-327)Gaa>Caa	p.E109Q	COPS2_ENST00000299259.6_Missense_Mutation_p.E109Q|COPS2_ENST00000542928.1_Missense_Mutation_p.E45Q	NM_001143887.1|NM_004236.3	NP_001137359.1|NP_004227.1	P61201	CSN2_HUMAN	COP9 signalosome subunit 2	109					cullin deneddylation|transcription from RNA polymerase II promoter	cytoplasm|signalosome	protein binding|signal transducer activity			cervix(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(8)|prostate(1)|skin(2)	18		all_lung(180;0.0428)		all cancers(107;1.34e-07)|GBM - Glioblastoma multiforme(94;3.02e-05)		ATGGATTTTTCAGAATAATTT	0.313000													31	34					0	0	1	0	0
ZNF324	25799	broad.mit.edu	37	19	58982235	58982235	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:58982235C>T	ENST00000536459.2	+	4	1085	c.376C>T	c.(376-378)Cgg>Tgg	p.R126W	ZNF324_ENST00000196482.3_Missense_Mutation_p.R126W			O75467	Z324A_HUMAN	zinc finger protein 324	126					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(2)|prostate(2)|urinary_tract(2)	16		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		GCAGAGACAACGGGGTGCCTC	0.602000													50	109					0	0	1	0	0
BTBD17	388419	broad.mit.edu	37	17	72353375	72353375	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:72353375C>T	ENST00000375366.3	-	3	984	c.858G>A	c.(856-858)ctG>ctA	p.L286L		NM_001080466.1	NP_001073935.1	A6NE02	BTBDH_HUMAN	BTB (POZ) domain containing 17	286						extracellular region				endometrium(1)|kidney(1)|lung(4)	6						AGGCCTGCAGCAGGAGGTCGG	0.711000													4	6					0	0	1	0	0
NXNL2	158046	broad.mit.edu	37	9	91150578	91150578	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:91150578C>T	ENST00000375855.3	+	1	559	c.229C>T	c.(229-231)Cag>Tag	p.Q77*	NXNL2_ENST00000487646.2_3'UTR|NXNL2_ENST00000375854.3_Nonsense_Mutation_p.Q77*	NM_145283.2	NP_660326.2	Q5VZ03	NXNL2_HUMAN	nucleoredoxin-like 2	77	Thioredoxin.									lung(3)	3						CGGCAGCTCCCAGGAGATGCT	0.706000													18	30					0	0	1	0	0
UGT2A1	10941	broad.mit.edu	37	4	70513304	70513304	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:70513304C>A	ENST00000503640.1	-	1	114	c.59G>T	c.(58-60)gGt>gTt	p.G20V	UGT2A1_ENST00000286604.4_Missense_Mutation_p.G20V|UGT2A1_ENST00000514019.1_Missense_Mutation_p.G20V|UGT2A1_ENST00000512704.1_Missense_Mutation_p.G20V	NM_006798.3	NP_006789.2	Q9Y4X1	UD2A1_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus	20					detection of chemical stimulus|sensory perception of smell	integral to membrane	glucuronosyltransferase activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(11)|ovary(2)|prostate(1)|skin(2)	30						AACATTCCCACCAAGAGTGGT	0.383000													7	12					0.00448238	0.00454542	1	1	0
SEPT14	346288	broad.mit.edu	37	7	55874908	55874908	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:55874908C>A	ENST00000388975.3	-	8	977	c.861G>T	c.(859-861)atG>atT	p.M287I		NM_207366.2	NP_997249.2	Q6ZU15	SEP14_HUMAN	septin 14	287					cell cycle|cell division	septin complex	GTP binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(15)|skin(2)	23	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TACAAAGAAGCATATCTCGGA	0.338000													3	54					0.115264	0.115746	1	1	0
CACNA1S	779	broad.mit.edu	37	1	201030503	201030503	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:201030503G>A	ENST00000362061.3	-	25	3373	c.3147C>T	c.(3145-3147)atC>atT	p.I1049I	CACNA1S_ENST00000367338.3_Silent_p.I1049I	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	1049	Dihydropyridine binding (By similarity).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CAATGAGGATGATGTAGATGA	0.512000													32	33					0	0	1	0	0
TELO2	9894	broad.mit.edu	37	16	1559872	1559872	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:1559872G>T	ENST00000262319.6	+	21	2728	c.2449G>T	c.(2449-2451)Gca>Tca	p.A817S		NM_016111.3	NP_057195.2	Q9Y4R8	TELO2_HUMAN	telomere maintenance 2	817						chromosome, telomeric region|cytoplasm|membrane|nucleus	protein binding			NS(1)|endometrium(1)|kidney(5)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	19		Hepatocellular(780;0.219)				CAGGACGCTGGCACTGAGGGC	0.642000													9	28					1.08611e-07	1.11869e-07	1	1	0
MALAT1	378938	broad.mit.edu	37	11	65267689	65267689	+	RNA	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:65267689G>C	ENST00000534336.1	+	0	2457					NR_002819.2																						GCTTTTGGAAGAGTTAGAAGA	0.333000													4	12					0	0	1	0	0
ADAM23	8745	broad.mit.edu	37	2	207452091	207452091	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:207452091C>G	ENST00000264377.3	+	19	2108	c.1780C>G	c.(1780-1782)Caa>Gaa	p.Q594E	ADAM23_ENST00000374415.3_Missense_Mutation_p.Q594E|ADAM23_ENST00000374416.1_Missense_Mutation_p.Q594E	NM_003812.2	NP_003803.1	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23	594	Cys-rich.				cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			NS(2)|breast(1)|endometrium(6)|kidney(3)|large_intestine(5)|liver(2)|lung(22)|ovary(2)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	51				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)		TGCATGCAATCAAAATCAGGT	0.289000													10	47					0	0	1	0	0
KL	9365	broad.mit.edu	37	13	33638310	33638310	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:33638310G>A	ENST00000380099.3	+	5	3034	c.3026G>A	c.(3025-3027)aGa>aAa	p.R1009K	KL_ENST00000487852.1_3'UTR	NM_004795.3	NP_004786.2	Q9UEF7	KLOT_HUMAN	klotho	1009					aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|skin(5)	41	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		AAAGGCAGAAGAAGTTACAAA	0.323000													10	25					0	0	1	0	0
ZC3H14	79882	broad.mit.edu	37	14	89044479	89044479	+	Missense_Mutation	SNP	A	A	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:89044479A>T	ENST00000251038.5	+	9	1499	c.1274A>T	c.(1273-1275)aAt>aTt	p.N425I	ZC3H14_ENST00000555755.1_Missense_Mutation_p.N425I|ZC3H14_ENST00000359301.3_Missense_Mutation_p.N391I|ZC3H14_ENST00000336693.4_Missense_Mutation_p.N391I|ZC3H14_ENST00000302216.8_Missense_Mutation_p.N425I|ZC3H14_ENST00000557605.1_3'UTR|ZC3H14_ENST00000557607.1_Missense_Mutation_p.N270I|ZC3H14_ENST00000393514.5_Missense_Mutation_p.N425I|ZC3H14_ENST00000556945.1_Missense_Mutation_p.N425I	NM_001160103.1|NM_001160104.1|NM_024824.4	NP_001153575.1|NP_001153576.1|NP_079100.2	Q6PJT7	ZC3HE_HUMAN	zinc finger CCCH-type containing 14	425						cytoplasm|nuclear speck	protein binding|RNA binding|zinc ion binding			cervix(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)|skin(2)	21						GTAGAAAAAAATCAAGGTAAT	0.343000													9	44					0	0	1	0	0
HSP90AA1	3320	broad.mit.edu	37	14	102551654	102551654	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:102551654C>G	ENST00000334701.7	-	5	1291	c.1010G>C	c.(1009-1011)gGa>gCa	p.G337A	HSP90AA1_ENST00000441629.2_Missense_Mutation_p.G36A|HSP90AA1_ENST00000216281.8_Missense_Mutation_p.G215A	NM_001017963.2	NP_001017963.2	P07900	HS90A_HUMAN	heat shock protein 90kDa alpha (cytosolic), class A member 1	215					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(6)|large_intestine(3)|liver(1)|lung(10)|ovary(2)|prostate(1)	28					Rifabutin(DB00615)	AATGGGATATCCAATAAACTG	0.378000													4	32					0	0	1	0	0
FOXN4	121643	broad.mit.edu	37	12	109719382	109719382	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:109719382G>C	ENST00000299162.5	-	9	1228	c.1124C>G	c.(1123-1125)tCt>tGt	p.S375C	FOXN4_ENST00000355216.1_Missense_Mutation_p.S195C	NM_213596.2	NP_998761.2	Q96NZ1	FOXN4_HUMAN	forkhead box N4	375					axon extension|embryo development|organ development|pattern specification process|regulation of heart contraction|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			large_intestine(5)|lung(9)|ovary(2)	16						TGGTGCTGGAGAGTCTGGAGC	0.682000													10	22					0	0	1	0	0
SSR3	6747	broad.mit.edu	37	3	156266665	156266665	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:156266665G>A	ENST00000467789.1	-	3	447	c.388C>T	c.(388-390)Cat>Tat	p.H130Y	SSR3_ENST00000478842.1_Intron|SSR3_ENST00000476217.1_Intron|SSR3_ENST00000265044.2_Intron|SSR3_ENST00000463503.1_Intron|SSR3_ENST00000496050.1_Intron			Q9UNL2	SSRG_HUMAN	signal sequence receptor, gamma (translocon-associated protein gamma)	120					cotranslational protein targeting to membrane	integral to endoplasmic reticulum membrane|microsome|Sec61 translocon complex	protein binding|signal sequence binding			endometrium(1)|prostate(2)	3			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			CCCCTTTTATGATGGCCATAC	0.338000													17	18					0	0	1	0	0
KCNV1	27012	broad.mit.edu	37	8	110984991	110984991	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:110984991C>G	ENST00000524391.1	-	3	1519	c.487G>C	c.(487-489)Gaa>Caa	p.E163Q	KCNV1_ENST00000297404.1_Missense_Mutation_p.E163Q			Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	163						voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(20)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			TCTAAAGTTTCACTCAGCTCT	0.383000													54	76					0	0	1	0	0
SLC45A1	50651	broad.mit.edu	37	1	8399581	8399581	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:8399581C>T	ENST00000471889.1	+	8	2188	c.1803C>T	c.(1801-1803)ctC>ctT	p.L601L	SLC45A1_ENST00000377479.2_Silent_p.L635L|SLC45A1_ENST00000289877.8_Silent_p.L601L			Q9Y2W3	S45A1_HUMAN	solute carrier family 45, member 1	601					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(2)	33	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		AGGAGTTCCTCAGCGTCCGCA	0.637000													40	85					0	0	1	0	0
ALPK3	57538	broad.mit.edu	37	15	85407673	85407673	+	Splice_Site	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:85407673G>A	ENST00000258888.5	+	12	5273	c.5106G>A	c.(5104-5106)gaG>gaA	p.E1702E		NM_020778.4	NP_065829.3	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1702	Alpha-type protein kinase.				heart development	nucleus	ATP binding|protein serine/threonine kinase activity			NS(3)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(4)|large_intestine(9)|lung(27)|ovary(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	81			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CTATGTTTAGGATCATCCCAC	0.517000													41	66					0	0	1	0	0
AGO4	192670	broad.mit.edu	37	1	36301442	36301442	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:36301442G>A	ENST00000373210.3	+	13	1817	c.1572G>A	c.(1570-1572)gtG>gtA	p.V524V		NM_017629.3	NP_060099.2			argonaute RISC catalytic component 4																		TAGCGGAGGTGAAACGTGTTG	0.368000													8	22					0	0	1	0	0
CACNA1F	778	broad.mit.edu	37	X	49079027	49079027	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chrX:49079027C>T	ENST00000376265.2	-	17	2336	c.2275G>A	c.(2275-2277)Gac>Aac	p.D759N	CACNA1F_ENST00000323022.5_Missense_Mutation_p.D748N|CACNA1F_ENST00000376251.1_Missense_Mutation_p.D694N|CACNA1F_ENST00000480889.1_5'UTR	NM_005183.2	NP_005174.2	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type, alpha 1F subunit	759					axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			autonomic_ganglia(1)|breast(8)|central_nervous_system(3)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(4)|urinary_tract(1)	85					Verapamil(DB00661)	GCCAGGTTGTCCACAGCAATG	0.562000													25	18					0	0	1	0	0
PSEN2	5664	broad.mit.edu	37	1	227071519	227071519	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:227071519G>A	ENST00000366782.1	+	5	854	c.354G>A	c.(352-354)gcG>gcA	p.A118A	PSEN2_ENST00000366783.3_Silent_p.A85A|PSEN2_ENST00000391872.2_Silent_p.A118A|PSEN2_ENST00000340188.4_Silent_p.A85A|PSEN2_ENST00000422240.2_Silent_p.A85A			P49810	PSN2_HUMAN	presenilin 2 (Alzheimer disease 4)	85					amyloid precursor protein catabolic process|anti-apoptosis|apoptosis|beta-amyloid metabolic process|calcium ion transport|induction of apoptosis by extracellular signals|intracellular signal transduction|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity	apical plasma membrane|axon|cell cortex|cell surface|centrosome|ciliary rootlet|dendritic shaft|endoplasmic reticulum membrane|Golgi membrane|growth cone|integral to plasma membrane|kinetochore|lysosomal membrane|membrane raft|mitochondrial inner membrane|neuromuscular junction|neuronal cell body|nuclear inner membrane|perinuclear region of cytoplasm|Z disc	aspartic-type endopeptidase activity|protein binding	p.A85A(1)		cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(8)|urinary_tract(1)	20		Prostate(94;0.0771)				AATACGGAGCGAAGCACGTGA	0.582000													34	131					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49443747	49443747	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:49443747G>C	ENST00000301067.7	-	11	3623	c.3624C>G	c.(3622-3624)atC>atG	p.I1208M		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D									p.I935I(1)|p.I1208I(1)									TCAGATTAGAGATCTCGTTAA	0.607000													26	43					0	0	1	0	0
ZFP36L2	678	broad.mit.edu	37	2	43452474	43452474	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:43452474C>T	ENST00000282388.3	-	2	762	c.469G>A	c.(469-471)Gag>Aag	p.E157K	THADA_ENST00000330266.7_Intron	NM_006887.4	NP_008818.3	P47974	TISD_HUMAN	ZFP36 ring finger protein-like 2	157					cell proliferation	nucleus	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.E157Q(1)		breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	15		Acute lymphoblastic leukemia(82;0.00323)|all_hematologic(82;0.00824)				CGGCACAGCTCGGTCTTGTAG	0.652000													12	45					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21422437	21422437	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr18:21422437C>A	ENST00000313654.9	+	28	3656	c.3415C>A	c.(3415-3417)Ccg>Acg	p.P1139T	LAMA3_ENST00000399516.3_Missense_Mutation_p.P1139T	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	1139	Domain IV 1 (domain IV B).				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGCAGCGCACCCGACGTTTCC	0.582000													56	85					6.07242e-22	6.51521e-22	1	1	0
MARK2	2011	broad.mit.edu	37	11	63666130	63666130	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:63666130G>A	ENST00000402010.2	+	5	967	c.388G>A	c.(388-390)Gag>Aag	p.E130K	MARK2_ENST00000350490.7_Missense_Mutation_p.E130K|MARK2_ENST00000513765.2_Missense_Mutation_p.E97K|MARK2_ENST00000508192.1_Missense_Mutation_p.E130K|MARK2_ENST00000502399.3_Missense_Mutation_p.E130K|MARK2_ENST00000413835.2_Missense_Mutation_p.E130K|MARK2_ENST00000377810.3_Missense_Mutation_p.E97K|MARK2_ENST00000315032.8_Missense_Mutation_p.E130K|MARK2_ENST00000377809.4_Missense_Mutation_p.E130K|MARK2_ENST00000425897.2_Missense_Mutation_p.E97K|MARK2_ENST00000509502.2_Missense_Mutation_p.E97K|MARK2_ENST00000408948.3_Missense_Mutation_p.E97K|MARK2_ENST00000361128.5_Missense_Mutation_p.E130K	NM_001039469.2	NP_001034558.2	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	130	Protein kinase.				cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity	p.E97*(1)		autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33						CCTTGTCATGGAGTACGCTAG	0.498000													47	121					0	0	1	0	0
AP1B1	162	broad.mit.edu	37	22	29745219	29745219	+	Missense_Mutation	SNP	G	G	C	rs144812422		TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr22:29745219G>C	ENST00000357586.2	-	11	1611	c.1425C>G	c.(1423-1425)gaC>gaG	p.D475E	AP1B1_ENST00000317368.7_Missense_Mutation_p.D475E|AP1B1_ENST00000415447.1_Missense_Mutation_p.D475E|AP1B1_ENST00000432560.2_Missense_Mutation_p.D475E|AP1B1_ENST00000356015.2_Missense_Mutation_p.D475E|AP1B1_ENST00000405198.1_Missense_Mutation_p.D475E|AP1B1_ENST00000402502.1_Missense_Mutation_p.D475E	NM_001127.3	NP_001118	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1, beta 1 subunit	475					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			endometrium(3)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						GTGTGCTCTCGTCATGGAAGC	0.612000													46	110					0	0	1	0	0
ANKAR	150709	broad.mit.edu	37	2	190593496	190593496	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:190593496G>A	ENST00000520309.1	+	15	3230	c.3142G>A	c.(3142-3144)Gct>Act	p.A1048T	ANKAR_ENST00000438402.2_Missense_Mutation_p.A1048T|ANKAR_ENST00000281412.6_Intron|ANKAR_ENST00000313581.4_Missense_Mutation_p.A1048T|ANKAR_ENST00000431575.2_Missense_Mutation_p.A977T	NM_144708.3	NP_653309.3	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	1048						integral to membrane	binding			breast(3)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(16)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(2)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			TAGTACGATTGCTGAAGGCAC	0.373000													55	28					0	0	1	0	0
COL25A1	84570	broad.mit.edu	37	4	109790268	109790268	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:109790268G>A	ENST00000399132.1	-	20	1589	c.1059C>T	c.(1057-1059)ggC>ggT	p.G353G	COL25A1_ENST00000399127.1_Silent_p.G349G|COL25A1_ENST00000399126.1_Silent_p.G353G	NM_198721.2	NP_942014.1	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1	353	Collagen-like 4.					collagen|extracellular space	beta-amyloid binding|heparin binding			NS(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(19)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	49		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		AACCTGGTAAGCCTGGTTCTC	0.343000													6	33					0	0	1	0	0
TPTE2P6	374491	broad.mit.edu	37	13	25161457	25161457	+	RNA	SNP	G	G	A	rs1851732	by1000genomes	TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:25161457G>A	ENST00000453498.1	+	0	981				TPTE2P6_ENST00000440905.1_RNA																							TTATTTATTCGATTCGTGGTA	0.378000													4	44					0	0	1	0	0
ZNF251	90987	broad.mit.edu	37	8	145947530	145947530	+	Missense_Mutation	SNP	A	A	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:145947530A>C	ENST00000292562.7	-	5	1790	c.1515T>G	c.(1513-1515)atT>atG	p.I505M	ZNF251_ENST00000524394.1_Intron	NM_138367.1	NP_612376.1	Q9BRH9	ZN251_HUMAN	zinc finger protein 251	505					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|kidney(1)|large_intestine(5)|lung(9)|stomach(1)	17	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;7.54e-38)|all cancers(56;6.19e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.198)		TCTGATGCTGAATGAGGGTTG	0.537000													64	66					0	0	1	0	0
FFAR2	2867	broad.mit.edu	37	19	35940871	35940871	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:35940871G>A	ENST00000599180.2	+	2	335	c.255G>A	c.(253-255)acG>acA	p.T85T	FFAR2_ENST00000601590.1_Intron|FFAR2_ENST00000246549.2_Silent_p.T85T			O15552	FFAR2_HUMAN	free fatty acid receptor 2							integral to plasma membrane	G-protein coupled receptor activity|lipid binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(6)|skin(1)|urinary_tract(1)	22	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			GCGCCCTCACGAGTTTTGGCT	0.622000													13	22					0	0	1	0	0
NUP155	9631	broad.mit.edu	37	5	37324164	37324164	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:37324164C>G	ENST00000231498.3	-	20	2340	c.2137G>C	c.(2137-2139)Gaa>Caa	p.E713Q	NUP155_ENST00000513532.1_Missense_Mutation_p.E713Q|NUP155_ENST00000381843.2_Missense_Mutation_p.E654Q	NM_153485.1	NP_705618.1	O75694	NU155_HUMAN	nucleoporin 155kDa	713					carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			endometrium(1)|kidney(16)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	62	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CCCTTTAGTTCTTGTAGCACT	0.358000													54	59					0	0	1	0	0
PIGB	9488	broad.mit.edu	37	15	55611498	55611498	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:55611498C>T	ENST00000164305.5	+	1	341	c.50C>T	c.(49-51)gCc>gTc	p.A17V	PIGB_ENST00000569909.1_3'UTR|PIGB_ENST00000539642.1_5'UTR	NM_004855.4	NP_004846.4	Q92521	PIGB_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class B	17					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	integral to membrane|intrinsic to endoplasmic reticulum membrane	glycolipid mannosyltransferase activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)	11				all cancers(107;0.0255)		GGCGGAGATGCCAGCCTCACT	0.592000													3	20					0	0	1	0	0
PAPD4	167153	broad.mit.edu	37	5	78915520	78915520	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:78915520C>T	ENST00000453514.1	+	2	742	c.49C>T	c.(49-51)Caa>Taa	p.Q17*	PAPD4_ENST00000423041.2_Nonsense_Mutation_p.Q17*|PAPD4_ENST00000296783.3_Nonsense_Mutation_p.Q17*|PAPD4_ENST00000504233.1_Nonsense_Mutation_p.Q17*|PAPD4_ENST00000428308.2_Nonsense_Mutation_p.Q17*	NM_001114394.1	NP_001107866.1	Q6PIY7	GLD2_HUMAN	PAP associated domain containing 4	17					histone mRNA catabolic process|mRNA processing|RNA polyadenylation	cytoplasm	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity			biliary_tract(1)|breast(2)|endometrium(4)|kidney(3)|large_intestine(9)|lung(4)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	29		Lung NSC(167;0.00293)|all_lung(232;0.00323)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;8.61e-47)|Epithelial(54;1.32e-41)|all cancers(79;2.45e-36)		TCCAAATCATCAACAACATAA	0.393000													20	28					0	0	1	0	0
CCDC40	55036	broad.mit.edu	37	17	78073333	78073333	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:78073333C>G	ENST00000397545.4	+	20	3215	c.3188C>G	c.(3187-3189)tCa>tGa	p.S1063*		NM_017950.3	NP_060420.2	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	1063					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(7)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	38	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			CAGAACCTTTCAGAGATCGTG	0.552000													34	35					0	0	1	0	0
MTX3	345778	broad.mit.edu	37	5	79279590	79279590	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:79279590G>A	ENST00000512560.1	-	8	792	c.673C>T	c.(673-675)Cag>Tag	p.Q225*	MTX3_ENST00000512528.1_Nonsense_Mutation_p.Q286*|MTX3_ENST00000509852.1_3'UTR	NM_001167741.1	NP_001161213.1	Q5HYI7	MTX3_HUMAN	metaxin 3	286					protein targeting to mitochondrion	mitochondrial outer membrane				endometrium(1)|large_intestine(3)|lung(2)|urinary_tract(1)	7		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.63e-45)|Epithelial(54;2.9e-40)|all cancers(79;4.68e-35)		GGAGGAAGCTGAGGGCTTTGG	0.468000													34	50					0	0	1	0	0
H2AFX	3014	broad.mit.edu	37	11	118965872	118965872	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:118965872C>T	ENST00000530167.1	-	1	305	c.233G>A	c.(232-234)cGa>cAa	p.R78Q		NM_002105.2	NP_002096.1	P16104	H2AX_HUMAN	H2A histone family, member X	78				R -> L (in Ref. 2; CAG33360).	DNA damage checkpoint|double-strand break repair via homologous recombination|meiosis|nucleosome assembly|positive regulation of DNA repair|response to ionizing radiation	nucleoplasm|nucleosome	DNA binding|enzyme binding|histone binding			lung(3)	3	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.47e-05)		GGGGATGATTCGCGTCTTCTT	0.682000								Chromatin Structure			OREG0021395	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	38	225					0	0	1	0	0
DOCK6	57572	broad.mit.edu	37	19	11332547	11332547	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:11332547G>A	ENST00000294618.7	-	28	3541	c.3530C>T	c.(3529-3531)cCa>cTa	p.P1177L	DOCK6_ENST00000319867.7_Missense_Mutation_p.P516L	NM_020812.3	NP_065863.2	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	1177					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|endometrium(11)|large_intestine(8)|liver(2)|lung(9)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	39						ATGCAGCCGTGGCAAGGTATC	0.587000													92	204					0	0	1	0	0
DYNC1LI1	51143	broad.mit.edu	37	3	32578521	32578521	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:32578521G>C	ENST00000273130.4	-	6	917	c.814C>G	c.(814-816)Cgg>Ggg	p.R272G	DYNC1LI1_ENST00000432458.2_Missense_Mutation_p.R156G	NM_016141.3	NP_057225.2	Q9Y6G9	DC1L1_HUMAN	dynein, cytoplasmic 1, light intermediate chain 1	272					cell division|interspecies interaction between organisms|mitosis|positive regulation of mitotic cell cycle spindle assembly checkpoint|transport	centrosome|condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|plasma membrane|spindle pole	ATP binding|motor activity			kidney(2)|large_intestine(1)|lung(3)|ovary(1)	7						CAAAACTTCCGGATATGTGAC	0.264000													23	46					0	0	1	0	0
PRSS16	10279	broad.mit.edu	37	6	27222869	27222869	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:27222869G>A	ENST00000230582.3	+	11	1450	c.1435G>A	c.(1435-1437)Gag>Aag	p.E479K	PRSS16_ENST00000421826.2_Missense_Mutation_p.E222K|PRSS16_ENST00000377456.2_3'UTR	NM_005865.3	NP_005856.1	Q9NQE7	TSSP_HUMAN	protease, serine, 16 (thymus)	479					protein catabolic process|proteolysis	cytoplasmic membrane-bounded vesicle	serine-type peptidase activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	26						CATGGCACCTGAGAGGCCCTC	0.507000													126	145					0	0	1	0	0
FBXO2	26232	broad.mit.edu	37	1	11708769	11708769	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:11708769G>A	ENST00000354287.4	-	6	1214	c.873C>T	c.(871-873)agC>agT	p.S291S		NM_012168.5	NP_036300.2	Q9UK22	FBX2_HUMAN	F-box protein 2	291	FBA.				glycoprotein catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|endoplasmic reticulum|membrane|microsome|SCF ubiquitin ligase complex	sugar binding|ubiquitin-protein ligase activity			kidney(1)|large_intestine(1)|lung(4)	6	Ovarian(185;0.249)	Lung NSC(185;9.37e-06)|all_lung(284;1.39e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|BRCA - Breast invasive adenocarcinoma(304;1.88e-06)|Colorectal(212;4.88e-06)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|Lung(427;0.0146)|LUSC - Lung squamous cell carcinoma(448;0.0228)|READ - Rectum adenocarcinoma(331;0.0649)		CTACCCACACGCTGCTGTTGG	0.657000													40	69					0	0	1	0	0
GHITM	27069	broad.mit.edu	37	10	85903844	85903844	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:85903844G>A	ENST00000372134.3	+	4	516	c.323G>A	c.(322-324)gGa>gAa	p.G108E		NM_014394.2	NP_055209.2	Q9H3K2	GHITM_HUMAN	growth hormone inducible transmembrane protein	108					apoptosis	integral to membrane|mitochondrial inner membrane				breast(1)|endometrium(1)|large_intestine(3)|lung(3)|prostate(2)	10						AATGAGATTGGAGCTATTGAA	0.398000													55	40					0	0	1	0	0
RPRML	388394	broad.mit.edu	37	17	45056167	45056167	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:45056167C>T	ENST00000322329.3	-	1	447	c.207G>A	c.(205-207)caG>caA	p.Q69Q	RP11-156P1.2_ENST00000571841.1_Intron|GOSR2_ENST00000439730.2_Intron|LRRC37A17P_ENST00000570478.1_RNA	NM_203400.4	NP_981945.1	Q8N4K4	RPRML_HUMAN	reprimo-like	69						integral to membrane				lung(1)	1						GCACGGCGATCTGCGCCACCC	0.687000													12	33					0	0	1	0	0
SYNJ1	8867	broad.mit.edu	37	21	34022588	34022588	+	Missense_Mutation	SNP	C	C	G	rs115683257	byFrequency	TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr21:34022588C>G	ENST00000382499.2	-	23	3059	c.3060G>C	c.(3058-3060)atG>atC	p.M1020I	SYNJ1_ENST00000433931.2_Missense_Mutation_p.M1020I|SYNJ1_ENST00000322229.7_Missense_Mutation_p.M981I|SYNJ1_ENST00000382491.3_Missense_Mutation_p.M976I|SYNJ1_ENST00000357345.3_Missense_Mutation_p.M981I	NM_203446.2	NP_982271.2	O43426	SYNJ1_HUMAN	synaptojanin 1	981	Pro-rich.						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|lung(11)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	57						TCTCTAAACTCATTTCTTCTT	0.353000													39	80					0	0	1	0	0
SEC22B	9554	broad.mit.edu	37	1	145109581	145109581	+	RNA	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:145109581G>A	ENST00000453618.1	+	0	570							O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)						ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding										CCTTCCCTAAGACGTTGGCTT	0.423000													35	350					0	0	1	0	0
CELSR2	1952	broad.mit.edu	37	1	109795716	109795716	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:109795716C>T	ENST00000271332.3	+	1	3076	c.3015C>T	c.(3013-3015)agC>agT	p.S1005S		NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	1005	Cadherin 8.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CTCTGGTGAGCCGGGCTACAG	0.567000													15	67					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577108	7577108	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:7577108C>A	ENST00000420246.2	-	8	962	c.830G>T	c.(829-831)tGt>tTt	p.C277F	TP53_ENST00000455263.2_Missense_Mutation_p.C277F|TP53_ENST00000413465.2_Intron|TP53_ENST00000359597.4_Missense_Mutation_p.C277F|TP53_ENST00000445888.2_Missense_Mutation_p.C277F|TP53_ENST00000269305.4_Missense_Mutation_p.C277F	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	277	Interaction with AXIN1 (By similarity).|Interaction with DNA.|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		C -> F (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).|C -> S (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> Y (in an osteosarcoma with no family history; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C277F(24)|p.C277Y(15)|p.0?(8)|p.?(2)|p.A276_R283delACPGRDRR(1)|p.C275fs*20(1)|p.A276fs*64(1)|p.L265_K305del41(1)|p.A276_C277delAC(1)|p.F270_D281del12(1)|p.V274_P278del(1)|p.S269fs*21(1)|p.C275fs*67(1)|p.C277S(1)|p.V272_K292del21(1)|p.C275_R283delCACPGRDRR(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCTCCCAGGACAGGCACAAAC	0.547000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			21	23					4.96729e-08	5.13097e-08	1	1	0
TOMM34	10953	broad.mit.edu	37	20	43580587	43580587	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:43580587G>A	ENST00000372813.3	-	4	589	c.437C>T	c.(436-438)tCa>tTa	p.S146L	PABPC1L_ENST00000490798.1_Intron|PABPC1L_ENST00000372819.1_Intron	NM_006809.4	NP_006800.2	Q15785	TOM34_HUMAN	translocase of outer mitochondrial membrane 34	146					protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane	heat shock protein binding|signal sequence binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)	11		Myeloproliferative disorder(115;0.0122)				CAAGGGGATTGAGGGCAGCTT	0.527000													40	172					0	0	1	0	0
DNM2	1785	broad.mit.edu	37	19	10897350	10897350	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:10897350C>T	ENST00000314646.5	+	7	1124	c.960C>T	c.(958-960)gaC>gaT	p.D320D	DNM2_ENST00000408974.4_Silent_p.D320D|DNM2_ENST00000585892.1_Silent_p.D320D|DNM2_ENST00000359692.6_Silent_p.D320D|DNM2_ENST00000355667.6_Silent_p.D320D|DNM2_ENST00000389253.4_Silent_p.D320D			P50570	DYN2_HUMAN	dynamin 2	320					G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	42			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			TTCGGCCCGACGACCCCACCC	0.637000			"""F, N, Splice, Mis, O"""		ETP ALL								21	27					0	0	1	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140734781	140734781	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:140734781C>G	ENST00000571252.1	+	1	14	c.14C>G	c.(13-15)cCt>cGt	p.P5R	PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_018917.2	NP_061740														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGGCGCCTCCTGCTCGCCCA	0.602000													22	28					0	0	1	0	0
SLC4A9	83697	broad.mit.edu	37	5	139741424	139741424	+	Missense_Mutation	SNP	T	T	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:139741424T>A	ENST00000230993.6	+	4	644	c.609T>A	c.(607-609)aaT>aaA	p.N203K	SLC4A9_ENST00000507527.1_Missense_Mutation_p.N203K|SLC4A9_ENST00000506545.1_Missense_Mutation_p.N179K|SLC4A9_ENST00000432095.2_Missense_Mutation_p.N179K|SLC4A9_ENST00000506757.2_Missense_Mutation_p.N179K	NM_001258428.1	NP_001245357.1	Q96Q91	B3A4_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 9	203						integral to membrane|plasma membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			endometrium(4)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)	14			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTTCTGACAATGAGGAAGCCC	0.502000													61	49					0	0	1	0	0
RNF175	285533	broad.mit.edu	37	4	154669807	154669807	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:154669807C>G	ENST00000274068.4	-	3	383	c.7G>C	c.(7-9)Gat>Cat	p.D3H	RNF175_ENST00000347063.4_Missense_Mutation_p.R79P|RNF175_ENST00000506505.1_5'UTR			Q8N4F7	RN175_HUMAN	ring finger protein 175	0						integral to membrane	zinc ion binding			breast(1)|endometrium(1)|large_intestine(5)|lung(1)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	13	all_hematologic(180;0.093)	Renal(120;0.118)				ATTGTAGGATCGGCCATGCCT	0.532000													4	16					0	0	1	0	0
SLC45A1	50651	broad.mit.edu	37	1	8386045	8386045	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:8386045G>A	ENST00000471889.1	+	4	1043	c.658G>A	c.(658-660)Gac>Aac	p.D220N	SLC45A1_ENST00000377479.2_Missense_Mutation_p.D254N|SLC45A1_ENST00000289877.8_Missense_Mutation_p.D220N			Q9Y2W3	S45A1_HUMAN	solute carrier family 45, member 1	220					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(2)	33	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		CTACATGATGGACGTGTGCAG	0.662000													65	167					0	0	1	0	0
HOXB9	3219	broad.mit.edu	37	17	46703546	46703546	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:46703546G>A	ENST00000311177.5	-	1	293	c.86C>T	c.(85-87)cCt>cTt	p.P29L	HOXB7_ENST00000567101.2_Intron|HOXB9_ENST00000550387.1_Missense_Mutation_p.P29L	NM_024017.4	NP_076922.1	P17482	HXB9_HUMAN	homeobox B9	29					canonical Wnt receptor signaling pathway|cell chemotaxis	mitochondrion|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(1)|large_intestine(1)|liver(1)|lung(6)|prostate(1)	12						CTGGCCAGAAGGAAACTTGGC	0.602000													6	24					0	0	1	0	0
DNAAF1	123872	broad.mit.edu	37	16	84211366	84211366	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:84211366G>C	ENST00000378553.5	+	12	2221	c.2097G>C	c.(2095-2097)gaG>gaC	p.E699D	DNAAF1_ENST00000563818.1_3'UTR	NM_178452.4	NP_848547.4	Q8NEP3	DAAF1_HUMAN	dynein, axonemal, assembly factor 1	699					axonemal dynein complex assembly|cilium morphogenesis	cilium axoneme|cytoplasm|spindle pole	dynein binding			NS(1)|endometrium(7)|kidney(1)|large_intestine(6)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|stomach(4)|urinary_tract(1)	41						CACCCCCAGAGACGTGTGTCG	0.592000													57	257					0	0	1	0	0
TRAF3IP2	10758	broad.mit.edu	37	6	111913199	111913199	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:111913199C>T	ENST00000368761.5	-	2	569	c.91G>A	c.(91-93)Gaa>Aaa	p.E31K	TRAF3IP2_ENST00000392556.4_5'UTR|TRAF3IP2_ENST00000359831.4_Missense_Mutation_p.E31K|TRAF3IP2-AS1_ENST00000532353.1_RNA|TRAF3IP2_ENST00000340026.6_Missense_Mutation_p.E40K	NM_001164281.2|NM_147686.3	NP_001157753.1|NP_679211.2	O43734	CIKS_HUMAN	TRAF3 interacting protein 2	40					intracellular signal transduction|positive regulation of I-kappaB kinase/NF-kappaB cascade	intracellular				central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|urinary_tract(1)	18		all_cancers(87;7.87e-06)|Acute lymphoblastic leukemia(125;3.61e-09)|all_hematologic(75;2.63e-07)|all_epithelial(87;0.0024)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.033)|all cancers(137;0.0412)|Epithelial(106;0.0732)		GGTTCTGATTCCTCTTCCGGG	0.463000													12	66					0	0	1	0	0
F11	2160	broad.mit.edu	37	4	187206844	187206844	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:187206844G>C	ENST00000264692.4	+	12	1534	c.1201G>C	c.(1201-1203)Gaa>Caa	p.E401Q	F11_ENST00000403665.2_Missense_Mutation_p.E453Q			P03951	FA11_HUMAN	coagulation factor XI	453	Peptidase S1.				blood coagulation, intrinsic pathway|plasminogen activation|positive regulation of fibrinolysis	extracellular space|plasma membrane	heparin binding|serine-type endopeptidase activity			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(15)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	32		all_cancers(14;6.2e-52)|all_epithelial(14;1.62e-38)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;2.13e-11)|BRCA - Breast invasive adenocarcinoma(30;4.59e-06)|GBM - Glioblastoma multiforme(59;0.000149)|STAD - Stomach adenocarcinoma(60;0.000314)|LUSC - Lung squamous cell carcinoma(40;0.00112)|READ - Rectum adenocarcinoma(43;0.176)	Coagulation Factor IX(DB00100)	AAATCAATCTGAAATAAAAGA	0.348000													10	44					0	0	1	0	0
MORC3	23515	broad.mit.edu	37	21	37744784	37744784	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr21:37744784C>A	ENST00000400485.1	+	16	2697	c.2621C>A	c.(2620-2622)aCa>aAa	p.T874K	MORC3_ENST00000487909.1_3'UTR	NM_015358.2	NP_056173.1	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	874					cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(9)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	35						GATGTTTCAACATCAAGTAAC	0.358000													13	47					1.5739e-10	1.64223e-10	1	1	0
LILRA2	11027	broad.mit.edu	37	19	55087422	55087422	+	Silent	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:55087422G>T	ENST00000251377.3	+	7	1234	c.1101G>T	c.(1099-1101)ctG>ctT	p.L367L	LILRB1_ENST00000396321.2_Intron|LILRA2_ENST00000251376.3_Silent_p.L367L|LILRA2_ENST00000391737.1_Silent_p.L355L|LILRB1_ENST00000418536.2_Intron|LILRA2_ENST00000391738.3_Silent_p.L367L|LILRB1_ENST00000448689.1_Intron					leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2											breast(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(33)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50				GBM - Glioblastoma multiforme(193;0.0963)		CACTGCATCTGAGATCAGAGC	0.587000													19	122					1.15919e-05	1.18718e-05	1	1	0
GPAM	57678	broad.mit.edu	37	10	113928632	113928632	+	Silent	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:113928632G>C	ENST00000348367.4	-	10	1070	c.873C>G	c.(871-873)ctC>ctG	p.L291L	GPAM_ENST00000369425.1_Silent_p.L291L|GPAM_ENST00000423155.1_Silent_p.L291L			Q9HCL2	GPAT1_HUMAN	glycerol-3-phosphate acyltransferase, mitochondrial	291					phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			breast(2)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31				Epithelial(162;0.0306)|all cancers(201;0.123)		AAGCTCTATAGAGAACATCTT	0.408000													31	30					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152187575	152187575	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:152187575G>A	ENST00000368801.2	-	3	6605	c.6530C>T	c.(6529-6531)tCt>tTt	p.S2177F	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	2177					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCAGATCCAGACCCTTGTCG	0.637000													36	295					0	0	1	0	0
PCSK7	9159	broad.mit.edu	37	11	117089803	117089803	+	Silent	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:117089803G>C	ENST00000320934.3	-	11	2031	c.1401C>G	c.(1399-1401)ctC>ctG	p.L467L	PCSK7_ENST00000540028.1_Silent_p.L108L	NM_004716.2	NP_004707.2	Q16549	PCSK7_HUMAN	proprotein convertase subtilisin/kexin type 7	467	Catalytic.				peptide hormone processing	integral to Golgi membrane	serine-type endopeptidase activity			NS(1)|endometrium(3)|large_intestine(2)|lung(8)|ovary(1)|skin(1)	16	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.72e-06)|Epithelial(105;6.71e-05)|all cancers(92;0.000537)		TCCAGGCGTTGAGGAGGCCGA	0.602000			T	IGH@	MLCLS								25	17					0	0	1	0	0
STARD5	80765	broad.mit.edu	37	15	81605709	81605709	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:81605709T>C	ENST00000302824.6	-	6	555	c.530A>G	c.(529-531)cAt>cGt	p.H177R		NM_181900.2	NP_871629.1	Q9NSY2	STAR5_HUMAN	StAR-related lipid transfer (START) domain containing 5	177	START.				C21-steroid hormone biosynthetic process|lipid transport	cytosol	lipid binding			large_intestine(3)|ovary(1)|skin(1)|stomach(1)	6						GAGGTCGGTATGGAAGAATGT	0.562000													58	86					0	0	1	0	0
STK38	11329	broad.mit.edu	37	6	36489566	36489566	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:36489566C>G	ENST00000229812.7	-	5	620	c.335G>C	c.(334-336)gGa>gCa	p.G112A		NM_007271.2	NP_009202.1	Q15208	STK38_HUMAN	serine/threonine kinase 38	112	Protein kinase.				intracellular protein kinase cascade|negative regulation of MAP kinase activity	cytoplasm|MLL5-L complex	ATP binding|magnesium ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity			NS(1)|endometrium(4)|large_intestine(2)|lung(9)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						ATACACATGTCCCGTATCTTT	0.358000													31	102					0	0	1	0	0
RAPH1	65059	broad.mit.edu	37	2	204304271	204304271	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:204304271C>G	ENST00000319170.5	-	14	3941	c.3642G>C	c.(3640-3642)caG>caC	p.Q1214H	ABI2_ENST00000295851.5_3'UTR|RAPH1_ENST00000457812.1_Intron|RAPH1_ENST00000374493.3_Missense_Mutation_p.Q1266H	NM_213589.1	NP_998754.1	Q70E73	RAPH1_HUMAN	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	1214					cell-matrix adhesion|signal transduction	cytoplasm|cytoskeleton|filopodium|lamellipodium|nucleus|plasma membrane				breast(5)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						AACCAGCCTTCTGTTGATCAG	0.562000													6	33					0	0	1	0	0
RNASEK	440400	broad.mit.edu	37	17	6915930	6915930	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:6915930G>C	ENST00000593646.1	-	3	519	c.520C>G	c.(520-522)Cgc>Ggc	p.R174G	RP11-589P10.7_ENST00000572547.1_RNA|RNASEK_ENST00000548577.1_Silent_p.A15A|RNASEK_ENST00000402093.1_5'UTR																							GCCCCCCTGCGAGGGCATCCT	0.692000													6	10					0	0	1	0	0
TYR	7299	broad.mit.edu	37	11	88911234	88911234	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:88911234C>T	ENST00000263321.5	+	1	615	c.113C>T	c.(112-114)cCg>cTg	p.P38L	TYR_ENST00000526139.1_3'UTR	NM_000372.4	NP_000363.1	P14679	TYRO_HUMAN	tyrosinase	38					eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(25)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	48		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)	TGCTGTCCACCGTGGAGCGGG	0.547000													48	50					0	0	1	0	0
NOS1AP	9722	broad.mit.edu	37	1	162337159	162337159	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:162337159G>T	ENST00000493151.1	+	2	2905	c.538G>T	c.(538-540)Gag>Tag	p.E180*	NOS1AP_ENST00000530878.1_Nonsense_Mutation_p.E470*|NOS1AP_ENST00000361897.5_Nonsense_Mutation_p.E475*|RP11-565P22.6_ENST00000431696.1_Intron|NOS1AP_ENST00000454693.1_3'UTR	NM_001126060.1	NP_001119532.2	O75052	CAPON_HUMAN	nitric oxide synthase 1 (neuronal) adaptor protein	475	PID.				regulation of apoptosis|regulation of nitric oxide biosynthetic process|regulation of nitric-oxide synthase activity		nitric-oxide synthase binding|PDZ domain binding			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(12)|skin(1)|upper_aerodigestive_tract(2)	32	all_hematologic(112;0.203)		BRCA - Breast invasive adenocarcinoma(70;0.0537)			CGAGAGCGAGGAGCGCGACTC	0.657000													7	97					0.00198382	0.00201455	1	1	0
SYTL2	54843	broad.mit.edu	37	11	85456690	85456690	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:85456690C>T	ENST00000316356.4	-	4	943	c.379G>A	c.(379-381)Gca>Aca	p.A127T	SYTL2_ENST00000527523.1_Missense_Mutation_p.A79T|SYTL2_ENST00000524452.1_Missense_Mutation_p.A127T|SYTL2_ENST00000528231.1_Missense_Mutation_p.A127T|SYTL2_ENST00000389960.4_Missense_Mutation_p.A127T			Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2	127					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(22)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		CTCGGGCTTGCTGGTGCTGCA	0.532000													78	192					0	0	1	0	0
POLK	51426	broad.mit.edu	37	5	74892219	74892219	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:74892219C>G	ENST00000241436.4	+	13	1873	c.1701C>G	c.(1699-1701)ttC>ttG	p.F567L	POLK_ENST00000506928.1_3'UTR|POLK_ENST00000508526.1_Missense_Mutation_p.F369L|POLK_ENST00000504026.1_Intron|POLK_ENST00000352007.5_Missense_Mutation_p.F369L|POLK_ENST00000380481.3_Missense_Mutation_p.F477L	NM_016218.2	NP_057302.1	Q9UBT6	POLK_HUMAN	polymerase (DNA directed) kappa	567					DNA replication|nucleotide-excision repair, DNA gap filling	nucleus	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			endometrium(1)|kidney(4)|large_intestine(5)|lung(11)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	27		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;2.9e-54)|all cancers(79;1.27e-42)		AGAAGAGTTTCTTTGATAAAA	0.373000								DNA polymerases (catalytic subunits)					13	11					0	0	1	0	0
PLK4	10733	broad.mit.edu	37	4	128804637	128804637	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:128804637T>C	ENST00000270861.5	+	4	540	c.266T>C	c.(265-267)tTa>tCa	p.L89S	PLK4_ENST00000514379.1_Missense_Mutation_p.L48S|PLK4_ENST00000515069.1_Missense_Mutation_p.L89S|PLK4_ENST00000511942.1_3'UTR|PLK4_ENST00000513090.1_Missense_Mutation_p.L57S|PLK4_ENST00000507249.1_Missense_Mutation_p.L89S	NM_014264.4	NP_055079.3	O00444	PLK4_HUMAN	polo-like kinase 4	89	Protein kinase.				G2/M transition of mitotic cell cycle|positive regulation of centriole replication|trophoblast giant cell differentiation	centriole|cleavage furrow|cytosol|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	31						TATCTGGTATTAGAAATGTGC	0.308000													18	27					0	0	1	0	0
KIF6	221458	broad.mit.edu	37	6	39313505	39313505	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:39313505C>G	ENST00000287152.7	-	21	2386	c.2292G>C	c.(2290-2292)caG>caC	p.Q764H	KIF6_ENST00000373216.3_Missense_Mutation_p.Q747H|KIF6_ENST00000373215.3_Missense_Mutation_p.Q747H|KIF6_ENST00000541946.1_Missense_Mutation_p.Q215H|KIF6_ENST00000538893.1_Missense_Mutation_p.Q708H|KIF6_ENST00000229913.5_Missense_Mutation_p.Q215H|KIF6_ENST00000394362.1_Missense_Mutation_p.Q198H|KIF6_ENST00000373213.4_Missense_Mutation_p.Q603H	NM_145027.4	NP_659464.3	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	764					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(16)|large_intestine(8)|lung(15)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	52						TGGTGCTGCTCTGTTTCTGGC	0.557000													27	37					0	0	1	0	0
DHX33	56919	broad.mit.edu	37	17	5352201	5352201	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:5352201C>A	ENST00000225296.3	-	11	1943	c.1743G>T	c.(1741-1743)gaG>gaT	p.E581D	DHX33_ENST00000433302.3_Missense_Mutation_p.E357D	NM_001199699.1|NM_020162.3	NP_001186628.1|NP_064547.2	Q9H6R0	DHX33_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 33	581						nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding	p.E581D(1)		breast(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						TGACAAAATTCTCTTTGCACC	0.458000													15	28					8.28177e-16	8.78111e-16	1	1	0
ZNF536	9745	broad.mit.edu	37	19	31040309	31040309	+	Silent	SNP	G	G	A	rs139373364		TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:31040309G>A	ENST00000355537.3	+	4	3930	c.3783G>A	c.(3781-3783)ccG>ccA	p.P1261P		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	1261					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					TGGACAAGCCGATGAACATGC	0.597000													9	27					0	0	1	0	0
CYP20A1	57404	broad.mit.edu	37	2	204154576	204154576	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:204154576G>A	ENST00000356079.4	+	10	1183	c.1060G>A	c.(1060-1062)Gac>Aac	p.D354N	CYP20A1_ENST00000429815.2_Missense_Mutation_p.D362N|CYP20A1_ENST00000461371.1_3'UTR	NM_177538.2	NP_803882.1	Q6UW02	CP20A_HUMAN	cytochrome P450, family 20, subfamily A, polypeptide 1	354						integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			cervix(1)|large_intestine(2)|lung(6)|ovary(1)|skin(1)	11						AGGAAAAATTGACCGATTTAT	0.333000													42	23					0	0	1	0	0
DNAJC13	23317	broad.mit.edu	37	3	132211337	132211337	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:132211337C>T	ENST00000260818.6	+	33	3951	c.3703C>T	c.(3703-3705)Cag>Tag	p.Q1235*		NM_015268.3	NP_056083.3	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	1235							heat shock protein binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|urinary_tract(1)	34						AGCACTTTATCAGTATTGCCC	0.403000													147	176					0	0	1	0	0
HAPLN2	60484	broad.mit.edu	37	1	156593740	156593740	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:156593740G>C	ENST00000255039.1	+	4	634	c.227G>C	c.(226-228)gGg>gCg	p.G76A		NM_021817.2	NP_068589.1	Q9GZV7	HPLN2_HUMAN	hyaluronan and proteoglycan link protein 2	76	Ig-like V-type.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			NS(1)|endometrium(2)|large_intestine(1)|lung(1)|skin(1)|urinary_tract(1)	7	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GTGGAGCCTGGGGAGCTCCGG	0.682000													20	9					0	0	1	0	0
KRT25	147183	broad.mit.edu	37	17	38910244	38910244	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:38910244G>A	ENST00000312150.4	-	3	597	c.537C>T	c.(535-537)caC>caT	p.H179H		NM_181534.3	NP_853512.1	Q7Z3Z0	K1C25_HUMAN	keratin 25	179	Coil 1B.|Rod.					cytoplasm|intermediate filament	structural molecule activity			endometrium(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(4)	16		Breast(137;0.00526)				CTACACTCTGGTGAAGAGCCA	0.408000													13	71					0	0	1	0	0
BUB1B	701	broad.mit.edu	37	15	40512774	40512774	+	Silent	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:40512774T>C	ENST00000287598.6	+	23	3162	c.2967T>C	c.(2965-2967)gaT>gaC	p.D989D	PAK6_ENST00000453867.1_Intron|BUB1B_ENST00000412359.3_Silent_p.D1003D|RP11-133K1.2_ENST00000558658.1_Intron|PAK6_ENST00000441369.1_Intron	NM_001211.5	NP_001202	O60566	BUB1B_HUMAN	BUB1 mitotic checkpoint serine/threonine kinase B	989	Protein kinase.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(7)|liver(2)|lung(17)|ovary(1)|stomach(2)|urinary_tract(2)	36		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)		GGCTAAAAGATGGTGAATTGT	0.358000			"""Mis, N, F, S"""			rhabdomyosarcoma			Mosaic Variegated Aneuploidy Syndrome				16	58					0	0	1	0	0
VWA7	80737	broad.mit.edu	37	6	31737803	31737803	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:31737803G>A	ENST00000375686.3	-	8	1412	c.1175C>T	c.(1174-1176)cCt>cTt	p.P392L	VWA7_ENST00000467576.1_5'UTR|VWA7_ENST00000447450.1_Missense_Mutation_p.P392L|VWA7_ENST00000375688.4_Missense_Mutation_p.P392L	NM_025258.2	NP_079534.2	Q9Y334	G7C_HUMAN	von Willebrand factor A domain containing 7	392						extracellular region											GCACATCTCAGGCTCGTCTCC	0.622000													32	80					0	0	1	0	0
MEP1A	4224	broad.mit.edu	37	6	46766860	46766860	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:46766860G>A	ENST00000230588.4	+	5	213	c.204G>A	c.(202-204)ctG>ctA	p.L68L		NM_005588.2	NP_005579.2	Q16819	MEP1A_HUMAN	meprin A, alpha (PABA peptide hydrolase)	68	Metalloprotease.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42			Lung(136;0.192)			GAAATGGCCTGAGAGACCCAA	0.428000													37	112					0	0	1	0	0
TRAPPC11	60684	broad.mit.edu	37	4	184607795	184607795	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:184607795C>T	ENST00000334690.6	+	18	1989	c.1787C>T	c.(1786-1788)gCc>gTc	p.A596V	TRAPPC11_ENST00000512476.1_Missense_Mutation_p.A202V|TRAPPC11_ENST00000357207.4_Missense_Mutation_p.A596V	NM_021942.5	NP_068761.4	Q7Z392	CD041_HUMAN	trafficking protein particle complex 11	596																	AAGTTTCATGCCCCAAGTTTT	0.413000													75	151					0	0	1	0	0
TRNAU1AP	54952	broad.mit.edu	37	1	28898397	28898397	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:28898397G>C	ENST00000373830.3	+	8	738	c.712G>C	c.(712-714)Gat>Cat	p.D238H		NM_017846.4	NP_060316.1	Q9NX07	TSAP1_HUMAN	tRNA selenocysteine 1 associated protein 1	238					selenocysteine incorporation	cytoplasm|nucleus	nucleotide binding|RNA binding			breast(1)|endometrium(2)|large_intestine(2)|ovary(1)|pancreas(1)|skin(1)	8						AGAAGTTGGAGATGATGCATT	0.473000													40	88					0	0	1	0	0
IL24	11009	broad.mit.edu	37	1	207072706	207072706	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:207072706A>G	ENST00000367093.3	+	3	363	c.89A>G	c.(88-90)cAg>cGg	p.Q30R	IL24_ENST00000391929.3_Missense_Mutation_p.Q30R|IL24_ENST00000294984.2_Missense_Mutation_p.Q29R|IL24_ENST00000491169.1_Intron	NM_001185157.1|NM_001185158.1	NP_001172086.1|NP_001172087.1	Q13007	IL24_HUMAN	interleukin 24	29					apoptosis	extracellular space	cytokine activity			endometrium(4)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)	12	Breast(84;0.201)					TCTCAAATGCAGATGGTTGTG	0.587000													38	29					0	0	1	0	0
ABHD12	26090	broad.mit.edu	37	20	25297683	25297683	+	Splice_Site	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:25297683C>A	ENST00000339157.5	-	5	846		c.e5+1		ABHD12_ENST00000376542.3_Splice_Site	NM_001042472.2	NP_001035937.1	Q8N2K0	ABD12_HUMAN	abhydrolase domain containing 12							integral to membrane	acylglycerol lipase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|liver(1)|lung(1)|skin(1)|urinary_tract(1)	12						CCTGCACTCACCTTGTAAAGC	0.547000													31	55					2.40579e-17	2.56215e-17	1	1	0
SV2B	9899	broad.mit.edu	37	15	91810843	91810843	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:91810843T>C	ENST00000394232.1	+	8	1648	c.1178T>C	c.(1177-1179)cTg>cCg	p.L393P	SV2B_ENST00000330276.4_Missense_Mutation_p.L393P|SV2B_ENST00000545111.2_Missense_Mutation_p.L242P	NM_014848.4	NP_055663.1	Q7L1I2	SV2B_HUMAN	synaptic vesicle glycoprotein 2B	393					neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			NS(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(17)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	42	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			ACACTGATTCTGGCCGTGGTT	0.443000													4	28					0	0	1	0	0
NUP214	8021	broad.mit.edu	37	9	134026030	134026030	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:134026030G>A	ENST00000359428.5	+	16	2299	c.2155G>A	c.(2155-2157)Gag>Aag	p.E719K	NUP214_ENST00000411637.2_Missense_Mutation_p.E709K|RP11-544A12.4_ENST00000589667.1_RNA|RP11-544A12.4_ENST00000415391.2_RNA|RP11-544A12.4_ENST00000588378.1_RNA|NUP214_ENST00000451030.1_Missense_Mutation_p.E720K|RP11-544A12.4_ENST00000587264.1_RNA|RP11-544A12.4_ENST00000586290.1_RNA|RP11-544A12.4_ENST00000590461.1_RNA|RP11-544A12.4_ENST00000587408.1_RNA|RP11-544A12.4_ENST00000589540.1_RNA			P35658	NU214_HUMAN	nucleoporin 214kDa	719	11 X 5 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			NS(1)|breast(9)|central_nervous_system(3)|endometrium(13)|kidney(2)|large_intestine(9)|liver(2)|lung(29)|ovary(2)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	86	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		GGAGTTGGAAGAGTTAAAAGC	0.438000			T	"""DEK, SET, ABL1"""	"""AML, T-ALL"""								15	79					0	0	1	0	0
GMFB	2764	broad.mit.edu	37	14	54948149	54948149	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:54948149C>T	ENST00000358056.3	-	4	446	c.178G>A	c.(178-180)Gaa>Aaa	p.E60K	GMFB_ENST00000553566.1_5'UTR|GMFB_ENST00000554908.1_3'UTR	NM_004124.2	NP_004115.1	P60983	GMFB_HUMAN	glia maturation factor, beta	60	ADF-H.				nervous system development|protein phosphorylation	intracellular	actin binding|enzyme activator activity|growth factor activity|protein kinase inhibitor activity|signal transducer activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(1)	8						TCAGGTAGTTCATCTTTAAGT	0.378000													6	42					0	0	1	0	0
PPP1R26	9858	broad.mit.edu	37	9	138376899	138376899	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:138376899C>T	ENST00000356818.2	+	4	1092	c.543C>T	c.(541-543)gcC>gcT	p.A181A	PPP1R26_ENST00000401470.3_Silent_p.A181A|PPP1R26_ENST00000605286.1_Silent_p.A181A|PPP1R26_ENST00000605660.1_Silent_p.A181A|PPP1R26_ENST00000602993.1_Intron|PPP1R26_ENST00000604351.1_Silent_p.A181A	NM_014811.3	NP_055626.3	Q5T8A7	K0649_HUMAN	protein phosphatase 1, regulatory subunit 26	181						nucleolus	protein binding										ACGGCAGTGCCCCGACTGCCC	0.706000													13	48					0	0	1	0	0
NLRP5	126206	broad.mit.edu	37	19	56538546	56538546	+	Missense_Mutation	SNP	T	T	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:56538546T>A	ENST00000390649.3	+	7	947	c.947T>A	c.(946-948)gTc>gAc	p.V316D		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	316	NACHT.					mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		TTCTCCTACGTCTTCTTCCTC	0.567000													8	14					0	0	1	0	0
HOXB3	3213	broad.mit.edu	37	17	46628332	46628332	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:46628332C>T	ENST00000470495.1	-	2	2107	c.660G>A	c.(658-660)gaG>gaA	p.E220E	HOXB3_ENST00000498678.1_Silent_p.E220E|HOXB-AS1_ENST00000502764.2_RNA|HOXB3_ENST00000460160.1_Silent_p.E88E|HOXB-AS3_ENST00000465846.2_RNA|HOXB3_ENST00000472863.1_Silent_p.E147E|HOXB3_ENST00000485909.2_Silent_p.E88E|HOXB3_ENST00000311626.4_Silent_p.E220E|HOXB-AS1_ENST00000508688.1_RNA|HOXB3_ENST00000489475.1_Silent_p.E147E|HOXB3_ENST00000476342.1_Silent_p.E220E|HOXB-AS1_ENST00000435312.1_RNA|HOXB3_ENST00000490677.1_Silent_p.E86E			P14651	HXB3_HUMAN	homeobox B3	220					angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(2)|lung(16)|prostate(4)|upper_aerodigestive_tract(1)	30						GGTTGGCCATCTCTACACGGC	0.607000													53	229					0	0	1	0	0
ATF6B	1388	broad.mit.edu	37	6	32086844	32086844	+	Missense_Mutation	SNP	T	T	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:32086844T>G	ENST00000375201.4	-	10	1077	c.1032A>C	c.(1030-1032)aaA>aaC	p.K344N	ATF6B_ENST00000375203.3_Missense_Mutation_p.K347N			Q99941	ATF6B_HUMAN	activating transcription factor 6 beta	347					response to unfolded protein|signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|prostate(2)|skin(1)|urinary_tract(1)	22						GCAGATACTCTTTCTTCTTTC	0.607000													24	34					0	0	1	0	0
UBE3B	89910	broad.mit.edu	37	12	109940905	109940905	+	Missense_Mutation	SNP	T	T	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:109940905T>A	ENST00000342494.3	+	14	1955	c.1360T>A	c.(1360-1362)Tct>Act	p.S454T	UBE3B_ENST00000434735.2_Missense_Mutation_p.S454T|UBE3B_ENST00000280774.5_Missense_Mutation_p.S454T|UBE3B_ENST00000535900.1_3'UTR	NM_130466.3	NP_569733.2	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	454					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			NS(1)|breast(3)|endometrium(6)|kidney(4)|large_intestine(7)|lung(20)|ovary(2)|urinary_tract(2)	45						ACGGGTCGACTCTGCAGAAGT	0.512000													19	87					0	0	1	0	0
TULP1	7287	broad.mit.edu	37	6	35478696	35478696	+	Silent	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:35478696C>G	ENST00000229771.6	-	5	520	c.441G>C	c.(439-441)ctG>ctC	p.L147L	TULP1_ENST00000322263.4_Silent_p.L94L	NM_003322.3	NP_003313.3	O00294	TULP1_HUMAN	tubby like protein 1	147					dendrite development|eye photoreceptor cell development|phagocytosis|photoreceptor cell maintenance|positive regulation of phagocytosis	cell junction|cytoplasm|extracellular region|photoreceptor inner segment|photoreceptor outer segment|synapse	actin filament binding|phosphatidylinositol-4,5-bisphosphate binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(5)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	19						TCTTCTCTCTCAGGGGCTTCT	0.592000													41	104					0	0	1	0	0
FAM168B	130074	broad.mit.edu	37	2	131810476	131810476	+	Nonstop_Mutation	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:131810476T>C	ENST00000409185.1	-	6	695	c.588A>G	c.(586-588)tgA>tgG	p.*196W	FAM168B_ENST00000389915.3_Nonstop_Mutation_p.*196W	NM_001009993.2	NP_001009993.2	A1KXE4	F168B_HUMAN	family with sequence similarity 168, member B	0										endometrium(3)|lung(2)	5						TTGCAGGTGATCACCACTGAG	0.557000													3	8					0	0	1	0	0
KANK2	25959	broad.mit.edu	37	19	11287304	11287304	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:11287304G>A	ENST00000432929.2	-	7	2094	c.1734C>T	c.(1732-1734)caC>caT	p.H578H	KANK2_ENST00000589894.1_Silent_p.H570H|KANK2_ENST00000589359.1_Silent_p.H578H|KANK2_ENST00000355150.5_Silent_p.H570H|KANK2_ENST00000586659.1_Silent_p.H570H	NM_001136191.2	NP_001129663.1	Q63ZY3	KANK2_HUMAN	KN motif and ankyrin repeat domains 2	570										endometrium(2)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						CAGTGGGTATGTGCTGAGATT	0.632000													70	244					0	0	1	0	0
CTSE	1510	broad.mit.edu	37	1	206320303	206320303	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:206320303G>A	ENST00000361052.3	+	4	564	c.446G>A	c.(445-447)gGa>gAa	p.G149E	CTSE_ENST00000360218.2_Missense_Mutation_p.G149E|CTSE_ENST00000432969.2_Missense_Mutation_p.G74E|CTSE_ENST00000358184.2_Missense_Mutation_p.G149E|CTSE_ENST00000468617.1_3'UTR			P14091	CATE_HUMAN	cathepsin E	149					antigen processing and presentation of exogenous peptide antigen via MHC class II|digestion|proteolysis	endosome	aspartic-type endopeptidase activity			endometrium(2)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|skin(3)	16			BRCA - Breast invasive adenocarcinoma(75;0.0754)			GGGATCATTGGAGCCGACCAA	0.493000													30	35					0	0	1	0	0
SLC22A8	9376	broad.mit.edu	37	11	62760793	62760793	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:62760793C>G	ENST00000336232.2	-	11	1680	c.1545G>C	c.(1543-1545)aaG>aaC	p.K515N	SLC22A8_ENST00000535878.1_Missense_Mutation_p.K392N|SLC22A8_ENST00000430500.2_Missense_Mutation_p.K515N|SLC22A8_ENST00000311438.8_3'UTR|SLC22A8_ENST00000545207.1_Missense_Mutation_p.K424N	NM_001184732.1|NM_001184736.1|NM_004254.3	NP_001171661.1|NP_001171665.1|NP_004245.2	Q8TCC7	S22A8_HUMAN	solute carrier family 22 (organic anion transporter), member 8	515					response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	28						GCTTTGGCTTCTTTGCCCGCA	0.632000													10	28					0	0	1	0	0
TMEM72	643236	broad.mit.edu	37	10	45430144	45430144	+	Silent	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:45430144G>C	ENST00000544540.1	+	4	520	c.36G>C	c.(34-36)ctG>ctC	p.L12L	TMEM72-AS1_ENST00000450287.2_RNA			A0PK05	TMM72_HUMAN	transmembrane protein 72	130						integral to membrane				breast(2)|kidney(1)|large_intestine(2)|lung(10)	15						ACTTCCTTCTGAGCAAGCGGA	0.602000													16	148					0	0	1	0	0
FRMPD2	143162	broad.mit.edu	37	10	49393605	49393605	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:49393605G>A	ENST00000374201.3	-	18	2652	c.2350C>T	c.(2350-2352)Cgt>Tgt	p.R784C	FRMPD2_ENST00000407470.4_Missense_Mutation_p.R752C|FRMPD2_ENST00000305531.3_Missense_Mutation_p.R759C	NM_001018071.3|NM_001042512.2	NP_001018081|NP_001035977.2	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2	784	PDZ 1.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding	p.R784C(1)		NS(2)|autonomic_ganglia(2)|breast(5)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(15)|lung(24)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	66				Kidney(211;0.201)		CCAAAACCACGATGTGGGTCA	0.502000													19	111					0	0	1	0	0
MYT1L	23040	broad.mit.edu	37	2	1855420	1855420	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:1855420G>A	ENST00000399161.2	-	19	3514	c.2767C>T	c.(2767-2769)Cat>Tat	p.H923Y	MYT1L_ENST00000428368.2_Missense_Mutation_p.H921Y	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	923					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		TACCTCCGATGAGAAGCATAA	0.433000													49	110					0	0	1	0	0
ABCB9	23457	broad.mit.edu	37	12	123434347	123434347	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:123434347C>T	ENST00000542678.1	-	4	3673	c.835G>A	c.(835-837)Gag>Aag	p.E279K	ABCB9_ENST00000392439.3_Missense_Mutation_p.E279K|ABCB9_ENST00000442833.2_Missense_Mutation_p.E279K|ABCB9_ENST00000280560.8_Missense_Mutation_p.E279K|ABCB9_ENST00000346530.5_Missense_Mutation_p.E279K|ABCB9_ENST00000344275.7_Missense_Mutation_p.E279K|ABCB9_ENST00000442028.2_Missense_Mutation_p.E279K|ABCB9_ENST00000540285.1_Missense_Mutation_p.E279K			Q9NP78	ABCB9_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 9	279	ABC transmembrane type-1.				positive regulation of T cell mediated cytotoxicity|protein transport	lysosomal membrane|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|protein homodimerization activity|TAP1 binding|TAP2 binding|tapasin binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(1)|skin(1)	18	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.84e-05)|Epithelial(86;0.000152)|BRCA - Breast invasive adenocarcinoma(302;0.111)		GTGCGGTTCTCATCAAAGAAG	0.572000													23	74					0	0	1	0	0
SRSF2	6427	broad.mit.edu	37	17	74732409	74732409	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:74732409C>T	ENST00000392485.2	-	2	672	c.500G>A	c.(499-501)cGa>cAa	p.R167Q	SRSF2_ENST00000359995.5_Missense_Mutation_p.R167Q|SRSF2_ENST00000508921.3_Missense_Mutation_p.R155Q|MFSD11_ENST00000586622.1_5'UTR|RP11-318A15.7_ENST00000587459.1_Intron|MFSD11_ENST00000588460.1_5'UTR	NM_003016.4	NP_003007.2	Q01130	SRSF2_HUMAN	serine/arginine-rich splicing factor 2	167	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|protein binding|RNA binding|transcription corepressor activity			haematopoietic_and_lymphoid_tissue(320)|kidney(2)|large_intestine(1)|lung(4)|prostate(2)	329						CTTGGACCTTCGTGCGGATCT	0.622000			Mis		"""MDS, CLL"""								20	92					0	0	1	0	0
DCAF10	79269	broad.mit.edu	37	9	37861326	37861326	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:37861326G>A	ENST00000242323.7	+	6	1464	c.1390G>A	c.(1390-1392)Gac>Aac	p.D464N	DCAF10_ENST00000377724.3_Missense_Mutation_p.D501N|RP11-613M10.9_ENST00000540557.1_Intron|DCAF10_ENST00000483167.1_3'UTR			Q5QP82	DCA10_HUMAN	DDB1 and CUL4 associated factor 10	501						CUL4 RING ubiquitin ligase complex				central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|skin(1)	12						GTTGGGATTTGACAAACAGTG	0.488000													36	127					0	0	1	0	0
ERG	2078	broad.mit.edu	37	21	39755585	39755585	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr21:39755585C>A	ENST00000442448.1	-	11	1400	c.1129G>T	c.(1129-1131)Ggg>Tgg	p.G377W	ERG_ENST00000398910.1_Missense_Mutation_p.G378W|ERG_ENST00000288319.7_Missense_Mutation_p.G394W|ERG_ENST00000398907.1_Missense_Mutation_p.G371W|ERG_ENST00000398919.2_Missense_Mutation_p.G401W|ERG_ENST00000398897.1_Missense_Mutation_p.G278W|ERG_ENST00000398905.1_Missense_Mutation_p.G370W|ERG_ENST00000417133.2_Missense_Mutation_p.G401W|ERG_ENST00000453032.2_Missense_Mutation_p.G302W|ERG_ENST00000398911.1_Missense_Mutation_p.G377W	NM_004449.4	NP_004440.1	P11308	ERG_HUMAN	v-ets avian erythroblastosis virus E26 oncogene homolog	401					cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		EWSR1/ERG(178)|NDRG1/ERG(5)|TMPRSS2/ERG(3582)|FUS/ERG(167)|SLC45A3/ERG(50)	lung(2)|ovary(1)|skin(1)	4		Prostate(19;3.6e-06)				TGGGCGATCCCGTGGAAGTCG	0.582000			T	"""EWSR1, TMPRSS2, ELF4, FUS, HERPUD1, NDRG1"""	"""Ewing sarcoma, prostate, AML"""								56	98					1.2582e-26	1.356e-26	1	1	0
ZNF385D	79750	broad.mit.edu	37	3	21466996	21466996	+	Silent	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:21466996C>G	ENST00000281523.2	-	6	1358	c.840G>C	c.(838-840)acG>acC	p.T280T		NM_024697.2	NP_078973.1	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	280						nucleus	nucleic acid binding|zinc ion binding			NS(2)|breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(1)|prostate(1)|skin(4)	46						GTTTAAGTTGCGTTTCCGAGT	0.413000													9	67					0	0	1	0	0
ROBO1	6091	broad.mit.edu	37	3	78649289	78649289	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:78649289C>T	ENST00000436010.2	-	28	5795	c.4798G>A	c.(4798-4800)Gga>Aga	p.G1600R	ROBO1_ENST00000464233.1_Missense_Mutation_p.G1639R|ROBO1_ENST00000495273.1_Missense_Mutation_p.G1594R|ROBO1_ENST00000467549.1_Missense_Mutation_p.G1539R|ROBO1_ENST00000466906.1_5'UTR			Q9Y6N7	ROBO1_HUMAN	roundabout, axon guidance receptor, homolog 1 (Drosophila)	1639					activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(25)|urinary_tract(1)	44		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		TTATCTTCTCCTCTTTCATAT	0.363000													3	17					0	0	1	0	0
DDB1	1642	broad.mit.edu	37	11	61099151	61099151	+	Missense_Mutation	SNP	G	G	A	rs35597036		TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:61099151G>A	ENST00000301764.7	-	2	471	c.74C>T	c.(73-75)tCg>tTg	p.S25L	DDB1_ENST00000450997.2_Missense_Mutation_p.S25L	NM_001923.4	NP_001914.3	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1, 127kDa	25	Interaction with CDT1.				cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	48						GTCTTCGGCCGAAGTAAAGTG	0.468000								Nucleotide excision repair (NER)					19	70					0	0	1	0	0
PPP1R15A	23645	broad.mit.edu	37	19	49379181	49379181	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:49379181C>T	ENST00000200453.5	+	3	2245	c.1976C>T	c.(1975-1977)tCg>tTg	p.S659L		NM_014330.3	NP_055145.3	O75807	PR15A_HUMAN	protein phosphatase 1, regulatory subunit 15A	659					apoptosis|cell cycle arrest|regulation of translation|response to DNA damage stimulus	endoplasmic reticulum	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(8)|skin(2)|urinary_tract(1)	23		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000244)|all cancers(93;0.000694)|GBM - Glioblastoma multiforme(486;0.0222)|Epithelial(262;0.033)		CCTTCCCGCTCGTCTGCTGCT	0.567000													82	169					0	0	1	0	0
WDR72	256764	broad.mit.edu	37	15	54003547	54003547	+	Silent	SNP	A	A	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:54003547A>G	ENST00000396328.1	-	8	1082	c.843T>C	c.(841-843)taT>taC	p.Y281Y	WDR72_ENST00000557913.1_Silent_p.Y280Y|WDR72_ENST00000559418.1_Silent_p.Y281Y|WDR72_ENST00000360509.5_Silent_p.Y281Y	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	281										NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		TCAGCAGCTGATAGATGTAAC	0.448000													34	58					0	0	1	0	0
CDK15	65061	broad.mit.edu	37	2	202744799	202744799	+	Missense_Mutation	SNP	A	A	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:202744799A>C	ENST00000450471.2	+	12	1193	c.1107A>C	c.(1105-1107)aaA>aaC	p.K369N	CDK15_ENST00000434439.1_Missense_Mutation_p.K369N|CDK15_ENST00000410091.3_Missense_Mutation_p.K318N|CDK15_ENST00000374598.4_Missense_Mutation_p.K369N|CDK15_ENST00000260967.2_Missense_Mutation_p.K318N	NM_001261435.1	NP_001248364.1	Q96Q40	CDK15_HUMAN	cyclin-dependent kinase 15	369	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity|metal ion binding|protein binding			breast(3)|endometrium(2)|kidney(5)|large_intestine(1)|lung(14)|ovary(1)	26					Adenosine triphosphate(DB00171)	AGATGCTAAAAGGCTTTCCCA	0.542000													16	53					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56369129	56369129	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:56369129G>A	ENST00000301295.6	+	3	792	c.370G>A	c.(370-372)Gag>Aag	p.E124K	NLRP4_ENST00000346986.5_Missense_Mutation_p.E124K|NLRP4_ENST00000587891.1_Missense_Mutation_p.E49K	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	124							ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		CCTATACTTTGAGGAGGAAGT	0.473000													34	69					0	0	1	0	0
FAM98A	25940	broad.mit.edu	37	2	33813494	33813494	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:33813494G>A	ENST00000403368.1	-	4	499	c.430C>T	c.(430-432)Caa>Taa	p.Q144*	FAM98A_ENST00000238823.8_Nonsense_Mutation_p.Q144*|FAM98A_ENST00000498340.1_Intron|FAM98A_ENST00000441530.2_Intron	NM_015475.3	NP_056290.3	Q8NCA5	FA98A_HUMAN	family with sequence similarity 98, member A	144										NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(1)	24	all_hematologic(175;0.115)					TTCAACTCTTGAAAGACCTCA	0.423000													35	87					0	0	1	0	0
CREBBP	1387	broad.mit.edu	37	16	3786760	3786760	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:3786760A>G	ENST00000262367.5	-	27	5260	c.4451T>C	c.(4450-4452)tTc>tCc	p.F1484S	CREBBP_ENST00000382070.3_Missense_Mutation_p.F1446S	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	1484	Cys/His-rich.|Interaction with TRERF1.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		GTGGCAATGGAAGATGTAATC	0.507000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						58	60					0	0	1	0	0
CPS1	1373	broad.mit.edu	37	2	211513262	211513262	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:211513262G>A	ENST00000233072.5	+	27	3598	c.3402G>A	c.(3400-3402)ttG>ttA	p.L1134L	CPS1_ENST00000430249.2_Silent_p.L1140L|CPS1_ENST00000451903.2_Silent_p.L683L	NM_001875.4	NP_001866.2	P31327	CPSM_HUMAN	carbamoyl-phosphate synthase 1, mitochondrial	1134	ATP-grasp 2.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(85)|ovary(8)|pancreas(1)|prostate(6)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	142				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		CCTATGTTTTGAGGTAACACT	0.348000													9	73					0	0	1	0	0
ARG2	384	broad.mit.edu	37	14	68086727	68086727	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:68086727C>T	ENST00000261783.3	+	1	213	c.33C>T	c.(31-33)ctC>ctT	p.L11L	ARG2_ENST00000556491.1_3'UTR	NM_001172.3	NP_001163.1	P78540	ARGI2_HUMAN	arginase 2	11					arginine metabolic process|nitric oxide biosynthetic process|urea cycle	mitochondrial matrix	arginase activity|metal ion binding	p.L11L(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|ovary(1)|prostate(1)	11				all cancers(60;0.000582)|OV - Ovarian serous cystadenocarcinoma(108;0.00392)|BRCA - Breast invasive adenocarcinoma(234;0.00928)	L-Arginine(DB00125)|L-Ornithine(DB00129)	CGCGTCTCCTCCAGACGCGAG	0.617000													3	17					0	0	1	0	0
CELSR2	1952	broad.mit.edu	37	1	109793958	109793958	+	Silent	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:109793958C>G	ENST00000271332.3	+	1	1318	c.1257C>G	c.(1255-1257)ctC>ctG	p.L419L		NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	419	Cadherin 3.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CCCCAGTACTCCGAGTCACAG	0.547000													62	85					0	0	1	0	0
VWA9	81556	broad.mit.edu	37	15	65871971	65871971	+	Silent	SNP	A	A	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:65871971A>C	ENST00000395644.4	-	12	1667	c.1332T>G	c.(1330-1332)gcT>gcG	p.A444A	VWA9_ENST00000420799.2_Silent_p.A387A|VWA9_ENST00000431261.2_Silent_p.A365A|VWA9_ENST00000442903.3_Silent_p.A408A|VWA9_ENST00000567744.1_Silent_p.A480A|VWA9_ENST00000313182.2_Silent_p.A444A|VWA9_ENST00000569491.1_Silent_p.A394A					von Willebrand factor A domain containing 9																		CAAAGGCTAGAGCGGCCTTTC	0.507000													15	53					0	0	1	0	0
KATNB1	10300	broad.mit.edu	37	16	57787344	57787344	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:57787344G>A	ENST00000379661.3	+	12	1482	c.1090G>A	c.(1090-1092)Gag>Aag	p.E364K		NM_005886.2	NP_005877.2	Q9BVA0	KTNB1_HUMAN	katanin p80 (WD repeat containing) subunit B 1	364	Interaction with PAFAH1B1 (By similarity).				cell division|mitosis|negative regulation of microtubule depolymerization|positive regulation of microtubule depolymerization|protein targeting	katanin complex|microtubule|spindle pole	microtubule binding|protein heterodimerization activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16		all_neural(199;0.223)				CCCCAGCAGCGAGGATGACCG	0.662000													10	77					0	0	1	0	0
MIB1	57534	broad.mit.edu	37	18	19321641	19321641	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr18:19321641G>A	ENST00000261537.6	+	1	361	c.97G>A	c.(97-99)Gag>Aag	p.E33K	MIB1_ENST00000578646.1_Intron	NM_020774.2	NP_065825.1	Q86YT6	MIB1_HUMAN	mindbomb E3 ubiquitin protein ligase 1	33	MIB/HERC2 1.				Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(13)|ovary(5)	27			STAD - Stomach adenocarcinoma(5;0.212)			GGACGGCGGCGAGGGCCATGT	0.667000													14	22					0	0	1	0	0
EHD4	30844	broad.mit.edu	37	15	42202032	42202032	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:42202032C>T	ENST00000220325.4	-	5	1037	c.954G>A	c.(952-954)aaG>aaA	p.K318K		NM_139265.3	NP_644670.1	Q9H223	EHD4_HUMAN	EH-domain containing 4	318					endocytic recycling|protein homooligomerization	early endosome membrane|endoplasmic reticulum|nucleus|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(7)|ovary(2)|stomach(1)|urinary_tract(1)	20		all_cancers(109;2.54e-12)|all_epithelial(112;6.59e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		OV - Ovarian serous cystadenocarcinoma(18;1.6e-19)|GBM - Glioblastoma multiforme(94;3.77e-06)|COAD - Colon adenocarcinoma(120;0.0474)|Colorectal(105;0.0538)		GCATCTCCTTCTTCAGGTAGC	0.438000													17	54					0	0	1	0	0
GAPVD1	26130	broad.mit.edu	37	9	128074826	128074826	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:128074826G>C	ENST00000470056.1	+	7	1697	c.1537G>C	c.(1537-1539)Gag>Cag	p.E513Q	GAPVD1_ENST00000265956.4_Missense_Mutation_p.E513Q|GAPVD1_ENST00000312123.9_Missense_Mutation_p.E513Q|GAPVD1_ENST00000297933.6_Missense_Mutation_p.E513Q|GAPVD1_ENST00000394083.2_Missense_Mutation_p.E513Q|GAPVD1_ENST00000394104.2_Missense_Mutation_p.E513Q|GAPVD1_ENST00000495955.1_Missense_Mutation_p.E513Q|GAPVD1_ENST00000394105.2_Missense_Mutation_p.E513Q			Q14C86	GAPD1_HUMAN	GTPase activating protein and VPS9 domains 1	513					endocytosis|regulation of protein transport|regulation of small GTPase mediated signal transduction|signal transduction	cytosol|endosome|membrane	GTPase activating protein binding|GTPase activator activity|guanyl-nucleotide exchange factor activity			central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(10)|lung(11)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						GCAACCAGAAGAGGTGTTGGT	0.433000													35	55					0	0	1	0	0
VCP	7415	broad.mit.edu	37	9	35059694	35059694	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:35059694G>A	ENST00000358901.6	-	14	2695	c.1800C>T	c.(1798-1800)gtC>gtT	p.V600V		NM_007126.3	NP_009057.1	P55072	TERA_HUMAN	valosin containing protein	600					activation of caspase activity|double-strand break repair|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|retrograde protein transport, ER to cytosol	cytosol|endoplasmic reticulum|microsome|nucleus|proteasome complex	ATP binding|ATPase activity|lipid binding|polyubiquitin binding|protein domain specific binding|protein phosphatase binding			breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	24			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			TCTGGTTGATGACTCGGTCAG	0.512000													111	102					0	0	1	0	0
TAOK1	57551	broad.mit.edu	37	17	27809286	27809286	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:27809286G>A	ENST00000261716.3	+	8	1154	c.635G>A	c.(634-636)gGa>gAa	p.G212E	TAOK1_ENST00000536202.1_Missense_Mutation_p.G212E	NM_020791.2	NP_065842.1	Q7L7X3	TAOK1_HUMAN	TAO kinase 1	212	Protein kinase.				mitotic prometaphase	cytosol|intracellular membrane-bounded organelle	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(14)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	28			Colorectal(6;0.198)			TGGTCTCTTGGAATAACATGT	0.318000													36	70					0	0	1	0	0
CCDC115	84317	broad.mit.edu	37	2	131098587	131098587	+	Silent	SNP	A	A	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:131098587A>C	ENST00000259229.2	-	4	547	c.324T>G	c.(322-324)acT>acG	p.T108T	CCDC115_ENST00000409127.1_Silent_p.T103T|CCDC115_ENST00000437688.2_Silent_p.T103T	NM_032357.2	NP_115733.2	Q96NT0	CC115_HUMAN	coiled-coil domain containing 115	108						endosome|lysosome				central_nervous_system(1)|large_intestine(2)|lung(3)|prostate(1)	7	Colorectal(110;0.1)					CTGGGGTCTTAGTGGGGCCCT	0.552000													5	17					0	0	1	0	0
C2orf70	339778	broad.mit.edu	37	2	26799014	26799014	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:26799014C>T	ENST00000409392.1	+	3	383	c.281C>T	c.(280-282)tCg>tTg	p.S94L	C2orf70_ENST00000329615.3_Missense_Mutation_p.R107C			A6NJV1	CB070_HUMAN	chromosome 2 open reading frame 70	0										breast(3)|endometrium(2)|large_intestine(1)|lung(4)|prostate(1)|skin(2)	13						GGACAGCCATCGCTCCACAGA	0.637000													81	113					0	0	1	0	0
RCN2	5955	broad.mit.edu	37	15	77241555	77241555	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:77241555G>A	ENST00000394885.3	+	7	1169	c.946G>A	c.(946-948)Gag>Aag	p.E316K	RCN2_ENST00000394883.3_Missense_Mutation_p.E215K|RCN2_ENST00000320963.5_Missense_Mutation_p.E334K	NM_002902.2	NP_002893.1	Q14257	RCN2_HUMAN	reticulocalbin 2, EF-hand calcium binding domain	316						endoplasmic reticulum lumen	calcium ion binding			endometrium(2)|kidney(2)|large_intestine(2)|lung(1)	7						CTATCATGATGAGCTTTAATC	0.388000													13	65					0	0	1	0	0
GRM7	2917	broad.mit.edu	37	3	7348315	7348315	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:7348315C>G	ENST00000486284.1	+	4	1283	c.1009C>G	c.(1009-1011)Cag>Gag	p.Q337E	GRM7_ENST00000357716.4_Missense_Mutation_p.Q337E|GRM7_ENST00000389336.4_Missense_Mutation_p.Q337E|GRM7_ENST00000402647.2_Missense_Mutation_p.Q337E|GRM7_ENST00000403881.1_Missense_Mutation_p.Q337E	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	337					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	CATCACCATTCAGCCCAAGCG	0.507000													9	78					0	0	1	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													4	79					0	0	1	0	0
GUSBP1	728411	broad.mit.edu	37	5	21459830	21459830	+	RNA	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:21459830C>T	ENST00000607545.1	+	0	73					NR_027026.1																						AGCTTGCGGTCACCATGGGCT	0.632000											OREG0016459	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	96					0	0	1	0	0
CCT6B	10693	broad.mit.edu	37	17	33259398	33259398	+	Silent	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:33259398G>C	ENST00000314144.5	-	11	1450	c.1335C>G	c.(1333-1335)ctC>ctG	p.L445L	CCT6B_ENST00000436961.3_Silent_p.L400L|CCT6B_ENST00000421975.3_Silent_p.L408L	NM_006584.3	NP_006575.2	Q92526	TCPW_HUMAN	chaperonin containing TCP1, subunit 6B (zeta 2)	445					chaperone-mediated protein complex assembly|protein folding|spermatogenesis	cytoplasm	ATP binding|protein transporter activity|unfolded protein binding			NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)	20		Ovarian(249;0.17)				TGGGAATAATGAGTAAGGCAT	0.383000													20	82					0	0	1	0	0
MAN2A2	4122	broad.mit.edu	37	15	91450061	91450061	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:91450061G>A	ENST00000360468.3	+	6	945	c.927G>A	c.(925-927)atG>atA	p.M309I	MAN2A2_ENST00000559717.1_Missense_Mutation_p.M309I	NM_006122.2	NP_006113.2	P49641	MA2A2_HUMAN	mannosidase, alpha, class 2A, member 2	309					mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|lung(13)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	47	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			TCACCAGCATGCTGATTCAGA	0.597000													24	69					0	0	1	0	0
POLR1A	25885	broad.mit.edu	37	2	86305369	86305369	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:86305369C>T	ENST00000263857.6	-	10	1503	c.1125G>A	c.(1123-1125)ttG>ttA	p.L375L	POLR1A_ENST00000409681.1_Silent_p.L375L			O95602	RPA1_HUMAN	polymerase (RNA) I polypeptide A, 194kDa	375					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	63						GAAGTGTACTCAAAAAGGATC	0.423000													22	41					0	0	1	0	0
LRIG1	26018	broad.mit.edu	37	3	66449393	66449393	+	Splice_Site	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:66449393C>T	ENST00000383703.3	-	11	1908		c.e11+1		LRIG1_ENST00000273261.3_Splice_Site|LRIG1_ENST00000496559.2_Splice_Site			Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like domains 1							integral to membrane				NS(2)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|prostate(1)|skin(4)|stomach(4)|urinary_tract(1)	42		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		GAGATACTCACAGGTGCTCCA	0.498000													9	25					0	0	1	0	0
ASB1	51665	broad.mit.edu	37	2	239353166	239353166	+	Silent	SNP	C	C	T	rs144070003	by1000genomes	TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:239353166C>T	ENST00000264607.4	+	4	925	c.678C>T	c.(676-678)gtC>gtT	p.V226V	ASB1_ENST00000409297.1_Silent_p.V125V	NM_001040445.1	NP_001035535.1	Q9Y576	ASB1_HUMAN	ankyrin repeat and SOCS box containing 1	226					intracellular signal transduction|negative regulation of cytokine biosynthetic process					breast(1)|kidney(1)|large_intestine(3)|lung(2)|skin(1)	8		all_epithelial(40;2.65e-14)|Breast(86;7.61e-05)|Renal(207;0.00183)|all_lung(227;0.0283)|Ovarian(221;0.0365)|Lung NSC(271;0.0941)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;2.04e-26)|OV - Ovarian serous cystadenocarcinoma(60;4.5e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;2.88e-05)|Lung(119;0.000383)|LUSC - Lung squamous cell carcinoma(224;0.00644)		ATGGTCCTGTCAACACACAGG	0.597000													6	99					0	0	1	0	0
SNORD3A	780851	broad.mit.edu	37	17	19091387	19091387	+	RNA	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:19091387G>C	ENST00000365494.1	+	0	59																											ttctctgaacgtgtagagcac	0.507000													22	475					0	0	1	0	0
LMBR1L	55716	broad.mit.edu	37	12	49494208	49494208	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:49494208G>A	ENST00000267102.8	-	15	1545	c.1203C>T	c.(1201-1203)gtC>gtT	p.V401V	LMBR1L_ENST00000547382.1_Silent_p.V381V|LMBR1L_ENST00000395141.4_Silent_p.V396V	NM_018113.2	NP_060583.2	Q6UX01	LMBRL_HUMAN	limb development membrane protein 1-like	401					endocytosis	integral to membrane|plasma membrane	receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(5)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						CTGAGCTTAGGACCAGGAGAC	0.498000													49	105					0	0	1	0	0
C12orf56	115749	broad.mit.edu	37	12	64784273	64784273	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:64784273G>T	ENST00000543942.2	-	1	699	c.73C>A	c.(73-75)Ctg>Atg	p.L25M	C12orf56_ENST00000333722.5_Missense_Mutation_p.L25M|RPS11P6_ENST00000535684.1_RNA	NM_001170633.1	NP_001164104.1	Q8IXR9	CL056_HUMAN	chromosome 12 open reading frame 56	25										NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)	15			GBM - Glioblastoma multiforme(3;0.000582)	GBM - Glioblastoma multiforme(28;0.0259)		TCGGGCGGCAGATGCCGCCGC	0.682000													29	46					9.65021e-13	1.01574e-12	1	1	0
RASIP1	54922	broad.mit.edu	37	19	49238513	49238513	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:49238513G>A	ENST00000222145.4	-	4	1323	c.1119C>T	c.(1117-1119)ctC>ctT	p.L373L	RASIP1_ENST00000594232.1_5'UTR	NM_017805.2	NP_060275.2	Q5U651	RAIN_HUMAN	Ras interacting protein 1	373					signal transduction	Golgi stack|perinuclear region of cytoplasm				central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(7)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	21		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000272)|Epithelial(262;0.0155)|GBM - Glioblastoma multiforme(486;0.0222)		GGGCCTGGATGAGGCACTGAG	0.667000													19	59					0	0	1	0	0
THAP11	57215	broad.mit.edu	37	16	67877394	67877394	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:67877394G>T	ENST00000303596.1	+	1	1182	c.937G>T	c.(937-939)Gga>Tga	p.G313*	CENPT_ENST00000562787.1_Intron	NM_020457.2	NP_065190.2	Q96EK4	THA11_HUMAN	THAP domain containing 11	313					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|identical protein binding|metal ion binding			cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|urinary_tract(1)	8		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00412)|Epithelial(162;0.018)|all cancers(182;0.118)		CAAGAAGCACGGAATGTGAAC	0.612000													31	39					6.53348e-20	6.98908e-20	1	1	0
DPP10	57628	broad.mit.edu	37	2	116572442	116572442	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:116572442G>A	ENST00000410059.1	+	20	2254	c.1774G>A	c.(1774-1776)Gat>Aat	p.D592N	DPP10_ENST00000310323.8_Missense_Mutation_p.D585N|DPP10_ENST00000409163.1_Missense_Mutation_p.D542N|DPP10_ENST00000393147.2_Missense_Mutation_p.D596N	NM_001178037.1|NM_020868.3	NP_001171508.1|NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl-peptidase 10 (non-functional)	592					proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(24)|liver(2)|lung(48)|ovary(6)|prostate(1)|skin(5)|soft_tissue(1)	101						CATTGACATGGATAATGTCAT	0.413000													20	73					0	0	1	0	0
DOCK7	85440	broad.mit.edu	37	1	62993932	62993932	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:62993932C>T	ENST00000251157.5	-	31	3859	c.3826G>A	c.(3826-3828)Gat>Aat	p.D1276N	DOCK7_ENST00000340370.5_Missense_Mutation_p.D1245N	NM_001271999.1	NP_001258928.1	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	1276					activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(19)|lung(42)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	92						CTTTCATAATCATCAGTGGCT	0.408000													14	22					0	0	1	0	0
KIF23	9493	broad.mit.edu	37	15	69737226	69737226	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:69737226C>T	ENST00000260363.4	+	19	2594	c.2477C>T	c.(2476-2478)tCt>tTt	p.S826F	KIF23_ENST00000558585.1_Missense_Mutation_p.S539F|KIF23_ENST00000559279.1_Missense_Mutation_p.S722F|KIF23_ENST00000352331.4_Missense_Mutation_p.S722F|KIF23_ENST00000537891.1_Missense_Mutation_p.S539F|KIF23_ENST00000395392.2_Missense_Mutation_p.S819F	NM_138555.2	NP_612565.1	Q02241	KIF23_HUMAN	kinesin family member 23	826					blood coagulation|cytokinesis|microtubule-based movement|mitosis|mitotic spindle elongation	cytosol|kinesin complex|microtubule|midbody|nucleoplasm|spindle	ATP binding|microtubule motor activity|protein binding			central_nervous_system(1)|endometrium(4)|large_intestine(7)|lung(6)|prostate(2)|skin(1)	21						AAGCCCGCCTCTAACATGCAA	0.478000													56	78					0	0	1	0	0
PPP2R3C	55012	broad.mit.edu	37	14	35557192	35557192	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:35557192G>A	ENST00000261475.5	-	12	1491	c.1138C>T	c.(1138-1140)Cat>Tat	p.H380Y		NM_017917.2	NP_060387.2	Q969Q6	P2R3C_HUMAN	protein phosphatase 2, regulatory subunit B'', gamma	380						centrosome|nucleus	calcium ion binding			central_nervous_system(1)|kidney(1)|large_intestine(8)|lung(4)|ovary(1)	15	Breast(36;0.0545)|Hepatocellular(127;0.158)|Prostate(35;0.184)		Lung(238;8.62e-06)|LUAD - Lung adenocarcinoma(48;1.42e-05)|Epithelial(34;0.0177)|all cancers(34;0.0491)	GBM - Glioblastoma multiforme(112;0.0803)		TCTTGTCCATGGATTTTCATT	0.308000													13	24					0	0	1	0	0
G6PC2	57818	broad.mit.edu	37	2	169759031	169759031	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:169759031G>A	ENST00000375363.3	+	2	387	c.295G>A	c.(295-297)Gaa>Aaa	p.E99K	G6PC2_ENST00000429379.2_Missense_Mutation_p.E99K|SPC25_ENST00000472216.2_Intron|G6PC2_ENST00000421979.1_Intron	NM_021176.2	NP_066999.1	Q9NQR9	G6PC2_HUMAN	glucose-6-phosphatase, catalytic, 2	99					gluconeogenesis|glucose homeostasis|glucose transport|regulation of insulin secretion|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	glucose-6-phosphatase activity			breast(1)|endometrium(1)|large_intestine(1)|lung(5)|pancreas(1)|prostate(1)|skin(1)|stomach(2)	13						TCCATGCCTTGAACAGTTCCC	0.393000													14	63					0	0	1	0	0
COL4A3	1285	broad.mit.edu	37	2	228157990	228157990	+	Silent	SNP	A	A	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:228157990A>T	ENST00000396578.3	+	38	3456	c.3294A>T	c.(3292-3294)ggA>ggT	p.G1098G	AC097662.2_ENST00000396588.2_RNA|AC097662.2_ENST00000439598.2_RNA|AC097662.2_ENST00000433324.1_RNA	NM_000091.4	NP_000082.2	Q01955	CO4A3_HUMAN	collagen, type IV, alpha 3 (Goodpasture antigen)	1098	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		GGCCTGCTGGACCTGAGGGAG	0.527000													3	29					0	0	1	0	0
PCNT	5116	broad.mit.edu	37	21	47858172	47858172	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr21:47858172G>A	ENST00000359568.5	+	41	9302	c.9195G>A	c.(9193-9195)gaG>gaA	p.E3065E	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	3065	Interaction with NEK2.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					TGACCCAGGAGAAGCTGGAGC	0.527000													8	61					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179480041	179480041	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:179480041C>T	ENST00000589042.1	-	259	48855	c.48631G>A	c.(48631-48633)Gaa>Aaa	p.E16211K	TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E14570K|TTN_ENST00000342175.6_Missense_Mutation_p.E7338K|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E7146K|TTN_ENST00000342992.6_Missense_Mutation_p.E13643K|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E7271K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	14570	Fibronectin type-III 17.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TACTTTGTTTCTGCAACAGGT	0.373000													23	36					0	0	1	0	0
VWC2	375567	broad.mit.edu	37	7	49815164	49815164	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:49815164C>G	ENST00000340652.4	+	2	689	c.133C>G	c.(133-135)Cag>Gag	p.Q45E		NM_198570.3	NP_940972.2	Q2TAL6	VWC2_HUMAN	von Willebrand factor C domain containing 2						negative regulation of BMP signaling pathway|positive regulation of neuron differentiation	basement membrane|extracellular space				cervix(1)|endometrium(2)|large_intestine(1)|lung(3)|prostate(1)	8						GCAGCCGGGCCAGGAGAAGCG	0.716000													9	6					0	0	1	0	0
MIR9-3	407051	broad.mit.edu	37	15	89911325	89911325	+	RNA	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:89911325G>A	ENST00000385084.1	+	0	78					NR_029692.1																						ACCGAAAGTAGAAATGATTCT	0.627000													13	18					0	0	1	0	0
MIPEP	4285	broad.mit.edu	37	13	24449002	24449002	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:24449002G>A	ENST00000382172.3	-	5	684	c.586C>T	c.(586-588)Cat>Tat	p.H196Y		NM_005932.3	NP_005923	Q99797	MIPEP_HUMAN	mitochondrial intermediate peptidase	196					protein processing involved in protein targeting to mitochondrion|proteolysis	mitochondrial matrix	metal ion binding|metalloendopeptidase activity			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|liver(1)|lung(12)|prostate(2)|skin(1)	27		all_cancers(29;1.83e-22)|all_epithelial(30;8.75e-19)|all_lung(29;9.17e-18)|Lung SC(185;0.0225)|Breast(139;0.14)		all cancers(112;0.00389)|Epithelial(112;0.0266)|OV - Ovarian serous cystadenocarcinoma(117;0.0717)|Lung(94;0.207)|GBM - Glioblastoma multiforme(144;0.232)		TTGTCTAGATGGATTCCACTA	0.323000													27	109					0	0	1	0	0
ELAC2	60528	broad.mit.edu	37	17	12897026	12897026	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:12897026C>T	ENST00000338034.4	-	23	2470	c.2231G>A	c.(2230-2232)gGa>gAa	p.G744E	ELAC2_ENST00000426905.3_Missense_Mutation_p.G704E|ELAC2_ENST00000395962.2_Missense_Mutation_p.G725E	NM_018127.6|NM_173717.1	NP_060597.4|NP_776065.1	Q9BQ52	RNZ2_HUMAN	elaC ribonuclease Z 2	744					tRNA processing	nucleus	endonuclease activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(8)|skin(1)	23						AAAGGCAACTCCCACTTTCTC	0.577000													15	113					0	0	1	0	0
DEF6	50619	broad.mit.edu	37	6	35288972	35288972	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:35288972C>T	ENST00000316637.5	+	11	1686	c.1681C>T	c.(1681-1683)Ccg>Tcg	p.P561S	DEF6_ENST00000542066.1_Missense_Mutation_p.P306S	NM_022047.3	NP_071330.3	Q9H4E7	DEFI6_HUMAN	differentially expressed in FDCP 6 homolog (mouse)	561						cytoplasm|nucleus|plasma membrane				cervix(1)|endometrium(2)|large_intestine(4)|lung(5)|ovary(1)|upper_aerodigestive_tract(2)	15						AGATAAGCGTCCGGTCACCAG	0.627000													189	298					0	0	1	0	0
COG1	9382	broad.mit.edu	37	17	71192710	71192710	+	Missense_Mutation	SNP	T	T	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:71192710T>A	ENST00000299886.4	+	2	460	c.380T>A	c.(379-381)aTt>aAt	p.I127N	RP11-143K11.5_ENST00000580671.1_RNA	NM_018714.2	NP_061184.1	Q8WTW3	COG1_HUMAN	component of oligomeric golgi complex 1	127					Golgi organization|intra-Golgi vesicle-mediated transport|protein transport	Golgi membrane|Golgi transport complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18			LUSC - Lung squamous cell carcinoma(166;0.197)			CTCTTAGAAATTCCGGAGAAG	0.557000													65	118					0	0	1	0	0
RAI1	10743	broad.mit.edu	37	17	17696270	17696270	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:17696270C>G	ENST00000353383.1	+	3	477	c.8C>G	c.(7-9)tCt>tGt	p.S3C	RAI1_ENST00000261641.6_Missense_Mutation_p.S3C	NM_030665.3	NP_109590.3	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	3						cytoplasm|nucleus	zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|prostate(1)|skin(5)|urinary_tract(7)	48				READ - Rectum adenocarcinoma(1115;0.0276)		GTCATGCAGTCTTTTCGAGAA	0.552000													21	33					0	0	1	0	0
TRAM1	23471	broad.mit.edu	37	8	71510491	71510491	+	Splice_Site	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:71510491C>T	ENST00000521425.1	-	3	966		c.e3-1		TRAM1_ENST00000262213.2_Splice_Site|TRAM1_ENST00000521049.1_Intron|TRAM1_ENST00000536748.1_Splice_Site			Q15629	TRAM1_HUMAN	translocation associated membrane protein 1						cotranslational protein targeting to membrane|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity			endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)	17			Epithelial(68;0.00679)|all cancers(69;0.0324)|OV - Ovarian serous cystadenocarcinoma(28;0.0509)			GCTTGTTCTTCTGAAGACCAA	0.333000													13	35					0	0	1	0	0
KCNJ15	3772	broad.mit.edu	37	21	39671488	39671488	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr21:39671488C>G	ENST00000328656.4	+	4	608	c.305C>G	c.(304-306)tCa>tGa	p.S102*	KCNJ15_ENST00000398932.1_Nonsense_Mutation_p.S102*|KCNJ15_ENST00000398934.1_Nonsense_Mutation_p.S102*|KCNJ15_ENST00000398930.1_Nonsense_Mutation_p.S102*|KCNJ15_ENST00000398938.2_Nonsense_Mutation_p.S102*	NM_001276437.1|NM_001276438.1|NM_001276439.1|NM_002243.3	NP_001263366.1|NP_001263367.1|NP_001263368.1|NP_002234.2	Q99712	IRK15_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 15						synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	24						GAGCCCATTTCAAATCATACC	0.493000													52	69					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33916209	33916209	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:33916209C>T	ENST00000389232.4	+	20	2629	c.2559C>T	c.(2557-2559)ccC>ccT	p.P853P	RYR3_ENST00000415757.3_Silent_p.P853P	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	853	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TCCCATGCCCCGTAGACACCA	0.438000													76	129					0	0	1	0	0
KCNK7	10089	broad.mit.edu	37	11	65363055	65363055	+	Silent	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:65363055C>A	ENST00000394216.2	-	1	412	c.189G>T	c.(187-189)ctG>ctT	p.L63L	KCNK7_ENST00000340313.4_Silent_p.L63L|KCNK7_ENST00000342202.4_Silent_p.L63L|KCNK7_ENST00000394217.2_Silent_p.L63L	NM_005714.1|NM_033455.1	NP_005705.1|NP_258416.1	Q9Y2U2	KCNK7_HUMAN	potassium channel, subfamily K, member 7	63						integral to membrane	potassium channel activity|voltage-gated ion channel activity			endometrium(1)|liver(1)|lung(1)	3						GCAGCTCTTCCAGAGCTCCGG	0.687000													8	7					0.000157383	0.000160727	1	1	0
SLC29A2	3177	broad.mit.edu	37	11	66134033	66134033	+	Missense_Mutation	SNP	C	C	T	rs141666252		TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:66134033C>T	ENST00000357440.2	-	8	964	c.736G>A	c.(736-738)Gag>Aag	p.E246K	SLC29A2_ENST00000546034.1_Missense_Mutation_p.E246K|SLC29A2_ENST00000311161.7_Intron|SLC29A2_ENST00000544554.1_Missense_Mutation_p.E246K	NM_001532.2	NP_001523.2	Q14542	S29A2_HUMAN	solute carrier family 29 (equilibrative nucleoside transporter), member 2	246					cell proliferation|nucleobase, nucleoside and nucleotide metabolic process	basolateral plasma membrane|integral to plasma membrane|nuclear membrane|nucleolus	nucleoside transmembrane transporter activity			breast(1)|kidney(2)|large_intestine(2)|lung(1)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	10						ATCCCGTTCTCATCTGGGGTG	0.577000													25	66					0	0	1	0	0
SPAG9	9043	broad.mit.edu	37	17	49198014	49198014	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:49198014C>G	ENST00000262013.7	-	1	212	c.4G>C	c.(4-6)Gag>Cag	p.E2Q	SPAG9_ENST00000357122.4_Missense_Mutation_p.E2Q|SPAG9_ENST00000505279.1_Missense_Mutation_p.E2Q	NM_001130528.2	NP_001124000.1	O60271	JIP4_HUMAN	sperm associated antigen 9	2					positive regulation of cell migration|positive regulation of muscle cell differentiation|retrograde transport, endosome to Golgi|spermatogenesis	acrosomal vesicle|integral to membrane|perinuclear region of cytoplasm				NS(1)|breast(3)|endometrium(3)|kidney(4)|large_intestine(8)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(1)	37			BRCA - Breast invasive adenocarcinoma(22;4.24e-07)			TCCTCCAGCTCCATGGTGGCA	0.746000													5	8					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94461703	94461703	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:94461703G>C	ENST00000370225.3	-	49	6864	c.6778C>G	c.(6778-6780)Ctg>Gtg	p.L2260V	ABCA4_ENST00000536513.1_Missense_Mutation_p.L530V|ABCA4_ENST00000535881.1_Missense_Mutation_p.L379V	NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	2260					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		CGAGGGTGCAGAGGGAGGTCA	0.517000													22	64					0	0	1	0	0
PANK2	80025	broad.mit.edu	37	20	3869809	3869809	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:3869809C>T	ENST00000316562.4	+	1	68	c.62C>T	c.(61-63)tCt>tTt	p.S21F	PANK2_ENST00000497424.1_Intron	NM_153638.2	NP_705902.2	Q9BZ23	PANK2_HUMAN	pantothenate kinase 2	21					cell death|coenzyme A biosynthetic process|pantothenate metabolic process	mitochondrial intermembrane space|nucleus	ATP binding|pantothenate kinase activity|protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						TCACTCTCTTCTGGGCTACAC	0.677000													19	14					0	0	1	0	0
RAD21	5885	broad.mit.edu	37	8	117864827	117864827	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:117864827C>A	ENST00000297338.2	-	10	1569	c.1282G>T	c.(1282-1284)Gag>Tag	p.E428*		NM_006265.2	NP_006256.1	O60216	RAD21_HUMAN	RAD21 homolog (S. pombe)	428					apoptosis|cell division|chromosome segregation|double-strand break repair|mitotic metaphase/anaphase transition|mitotic prometaphase|protein localization to chromatin|reciprocal meiotic recombination|regulation of transcription from RNA polymerase II promoter	chromosome, centromeric region|cohesin complex|nuclear chromosome|nucleoplasm	protein binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|skin(1)|stomach(1)	32	all_cancers(13;1.21e-21)|Lung NSC(37;0.000134)|Ovarian(258;0.0172)					TGCTGGTCCTCTCTAGGAACC	0.413000													18	126					6.33239e-15	6.6847e-15	1	1	0
PSD3	23362	broad.mit.edu	37	8	18729886	18729886	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:18729886C>T	ENST00000440756.2	-	3	590	c.488G>A	c.(487-489)aGt>aAt	p.S163N	PSD3_ENST00000523619.1_Missense_Mutation_p.S98N|PSD3_ENST00000327040.8_Missense_Mutation_p.S163N			Q9NYI0	PSD3_HUMAN	pleckstrin and Sec7 domain containing 3	163					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		AACTGAAAAACTAGAAACAGC	0.443000													9	31					0	0	1	0	0
ATG14	22863	broad.mit.edu	37	14	55852662	55852662	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:55852662C>A	ENST00000247178.5	-	5	597	c.562G>T	c.(562-564)Gag>Tag	p.E188*		NM_014924.4	NP_055739.2	Q6ZNE5	BAKOR_HUMAN	autophagy related 14	188					autophagic vacuole assembly|positive regulation of autophagy	autophagic vacuole|endoplasmic reticulum|pre-autophagosomal structure membrane	protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(6)|prostate(2)	13						GCCAGACGCTCATAATGACTT	0.423000													7	39					0.000442599	0.00045009	1	1	0
EFHC1	114327	broad.mit.edu	37	6	52344529	52344529	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:52344529C>T	ENST00000371068.5	+	9	1687	c.1584C>T	c.(1582-1584)ctC>ctT	p.L528L	EFHC1_ENST00000433625.2_Silent_p.L437L|EFHC1_ENST00000538167.1_Silent_p.L509L	NM_018100.3	NP_060570.2	Q5JVL4	EFHC1_HUMAN	EF-hand domain (C-terminal) containing 1	528						axoneme|neuronal cell body	calcium ion binding|protein C-terminus binding			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(8)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	27	Lung NSC(77;0.109)					CAGAAGCACTCGCGTCAATTC	0.478000													39	59					0	0	1	0	0
ITSN2	50618	broad.mit.edu	37	2	24538094	24538094	+	Splice_Site	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:24538094C>T	ENST00000355123.4	-	3	475		c.e3-1		ITSN2_ENST00000361999.3_Splice_Site|ITSN2_ENST00000406921.3_Splice_Site|ITSN2_ENST00000407704.1_Splice_Site	NM_006277.2	NP_006268.2	Q9NZM3	ITSN2_HUMAN	intersectin 2						endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(8)|large_intestine(11)|liver(3)|lung(28)|ovary(2)|stomach(1)	61	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTTGGCCCTCCTGAAACATAA	0.358000													14	43					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155158295	155158295	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:155158295G>C	ENST00000357232.4	-	25	6143	c.6144C>G	c.(6142-6144)atC>atG	p.I2048M		NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2		Cadherin 18.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		ATACGGGACTGATAGTAAATA	0.383000													14	17					0	0	1	0	0
DMXL2	23312	broad.mit.edu	37	15	51791720	51791720	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:51791720C>T	ENST00000251076.5	-	18	3988	c.3701G>A	c.(3700-3702)aGa>aAa	p.R1234K	DMXL2_ENST00000543779.2_Missense_Mutation_p.R1234K|DMXL2_ENST00000449909.3_Intron	NM_001174116.1|NM_015263.3	NP_001167587.1|NP_056078.2	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	1234						cell junction|synaptic vesicle membrane	Rab GTPase binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(26)|liver(1)|lung(28)|ovary(7)|prostate(7)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	101				all cancers(107;0.00494)		GTCTATAGATCTAAGAAGAAC	0.428000													30	53					0	0	1	0	0
CWF19L2	143884	broad.mit.edu	37	11	107205622	107205622	+	Missense_Mutation	SNP	T	T	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:107205622T>A	ENST00000282251.5	-	16	2451	c.2424A>T	c.(2422-2424)aaA>aaT	p.K808N		NM_152434.2	NP_689647.2	Q2TBE0	C19L2_HUMAN	CWF19-like 2, cell cycle control (S. pombe)	808							catalytic activity			endometrium(4)|kidney(2)|large_intestine(13)|lung(21)	40		Melanoma(852;1.75e-05)|all_epithelial(67;6.27e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0258)		Epithelial(105;7.18e-06)|BRCA - Breast invasive adenocarcinoma(274;1.65e-05)|all cancers(92;1.76e-05)		TTCTGATATCTTTTGAAGAGA	0.338000													12	77					0	0	1	0	0
ZNF134	7693	broad.mit.edu	37	19	58131977	58131977	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:58131977G>C	ENST00000396161.5	+	3	800	c.490G>C	c.(490-492)Gag>Cag	p.E164Q		NM_003435.3	NP_003426.3	P52741	ZN134_HUMAN	zinc finger protein 134	164						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(3)|prostate(1)	11		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		CAGGAGCACTGAGAGTGGGGA	0.488000													22	35					0	0	1	0	0
SNX14	57231	broad.mit.edu	37	6	86223790	86223790	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:86223790C>G	ENST00000314673.3	-	25	2731	c.2555G>C	c.(2554-2556)aGa>aCa	p.R852T	SNX14_ENST00000346348.3_Missense_Mutation_p.R799T|SNX14_ENST00000513865.1_Missense_Mutation_p.R571T|SNX14_ENST00000505648.1_Missense_Mutation_p.R800T|SNX14_ENST00000369627.2_Missense_Mutation_p.R843T|SNX14_ENST00000508980.1_5'UTR	NM_153816.3	NP_722523.1	Q9Y5W7	SNX14_HUMAN	sorting nexin 14	852					cell communication|protein transport	integral to membrane	phosphatidylinositol binding|signal transducer activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(11)|skin(1)	22		all_cancers(76;4.83e-07)|Acute lymphoblastic leukemia(125;3.3e-08)|Prostate(29;2.55e-07)|all_hematologic(105;3.66e-05)|all_epithelial(107;0.000695)|Lung NSC(302;0.197)|all_lung(197;0.24)		BRCA - Breast invasive adenocarcinoma(108;0.0423)		ATACAAACCTCTGAGAAGTGT	0.318000													34	36					0	0	1	0	0
TRAV3	28690	broad.mit.edu	37	14	22192435	22192435	+	RNA	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:22192435C>T	ENST00000390425.2	+	0	386																											TGAAATACATCACAGGGGATA	0.458000													24	44					0	0	1	0	0
IGLV9-49	28773	broad.mit.edu	37	22	22697785	22697785	+	RNA	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr22:22697785C>G	ENST00000427632.2	+	0	110																											TGTGCTGACTCAGCCACCTTC	0.587000											OREG0026357	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	58					0	0	1	0	0
MAP2K7	5609	broad.mit.edu	37	19	7974989	7974989	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:7974989C>T	ENST00000545011.1	+	3	373	c.308C>T	c.(307-309)aCg>aTg	p.T103M	MAP2K7_ENST00000397983.3_Missense_Mutation_p.T119M|MAP2K7_ENST00000397979.3_Missense_Mutation_p.T103M|MAP2K7_ENST00000397981.3_Missense_Mutation_p.T103M			O14733	MP2K7_HUMAN	mitogen-activated protein kinase kinase 7	103					activation of JUN kinase activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleus	ATP binding|JUN kinase kinase activity|magnesium ion binding|protein binding|protein kinase binding|protein phosphatase binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(2)|central_nervous_system(3)|endometrium(1)|large_intestine(8)|lung(4)|ovary(1)	19					Etoposide(DB00773)	ATGAAGCAGACGGGCTACCTG	0.647000													7	18					0	0	1	0	0
MATN4	8785	broad.mit.edu	37	20	43927050	43927050	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:43927050C>T	ENST00000537548.1	-	8	1430	c.1186G>A	c.(1186-1188)Gag>Aag	p.E396K	MATN4_ENST00000372751.4_Missense_Mutation_p.E247K|MATN4_ENST00000360607.6_Missense_Mutation_p.E355K|MATN4_ENST00000342716.4_Missense_Mutation_p.E396K|MATN4_ENST00000372754.1_Missense_Mutation_p.E437K|MATN4_ENST00000353917.5_Missense_Mutation_p.E314K|MATN4_ENST00000372756.1_Missense_Mutation_p.E396K			O95460	MATN4_HUMAN	matrilin 4	437	VWFA 2.					extracellular region	protein binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	27		Myeloproliferative disorder(115;0.0122)				AGAGGGAACTCGGTGCGCACG	0.657000													93	64					0	0	1	0	0
WAC	51322	broad.mit.edu	37	10	28897267	28897267	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:28897267C>T	ENST00000375664.4	+	8	1546	c.937C>T	c.(937-939)Cag>Tag	p.Q313*	WAC_ENST00000428935.1_Nonsense_Mutation_p.Q313*|WAC_ENST00000375646.1_Nonsense_Mutation_p.Q210*|WAC_ENST00000354911.4_Nonsense_Mutation_p.Q358*|WAC_ENST00000347934.4_Nonsense_Mutation_p.Q255*			Q9BTA9	WAC_HUMAN	WW domain containing adaptor with coiled-coil						cell cycle checkpoint|histone H2B conserved C-terminal lysine ubiquitination|histone monoubiquitination|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nuclear speck	chromatin binding|RNA polymerase II core binding			NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|urinary_tract(1)	32						TCCCTTACTTCAGGACCCAAA	0.458000													6	37					0	0	1	0	0
FZD6	8323	broad.mit.edu	37	8	104337528	104337528	+	Missense_Mutation	SNP	A	A	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:104337528A>C	ENST00000358755.4	+	4	1511	c.1194A>C	c.(1192-1194)caA>caC	p.Q398H	FZD6_ENST00000540287.1_Missense_Mutation_p.Q93H|FZD6_ENST00000523739.1_Missense_Mutation_p.Q366H|FZD6_ENST00000522566.1_Missense_Mutation_p.Q398H	NM_001164616.1|NM_003506.3	NP_001158088.1|NP_003497.2	O60353	FZD6_HUMAN	frizzled family receptor 6	398					angiogenesis|axonogenesis|cell proliferation in midbrain|establishment of planar polarity|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|neural tube closure|non-canonical Wnt receptor signaling pathway	apical part of cell|apicolateral plasma membrane|cytoplasm|integral to plasma membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	24			OV - Ovarian serous cystadenocarcinoma(57;2.86e-05)|STAD - Stomach adenocarcinoma(118;0.197)			ATGTTCGACAAGTCATACAAC	0.408000													68	194					0	0	1	0	0
GPR83	10888	broad.mit.edu	37	11	94134384	94134384	+	Silent	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:94134384G>T	ENST00000243673.2	-	1	201	c.30C>A	c.(28-30)ctC>ctA	p.L10L	GPR83_ENST00000539203.2_Silent_p.L10L	NM_016540.3	NP_057624.3	Q9NYM4	GPR83_HUMAN	G protein-coupled receptor 83	10						integral to membrane|plasma membrane	neuropeptide Y receptor activity			NS(1)|breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)	19		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				CCAAGGGGAGGAGACAGAGCA	0.711000													18	46					2.94398e-08	3.05412e-08	1	1	0
TRAV3	28690	broad.mit.edu	37	14	22192379	22192379	+	RNA	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:22192379C>G	ENST00000390425.2	+	0	330																											AAACCCTTATCTTTTTTGGTA	0.478000													24	44					0	0	1	0	0
ATP11A	23250	broad.mit.edu	37	13	113532536	113532536	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:113532536G>C	ENST00000487903.1	+	29	3421	c.3333G>C	c.(3331-3333)aaG>aaC	p.K1111N	ATP11A_ENST00000375645.3_Missense_Mutation_p.K1111N|ATP11A_ENST00000375630.2_Intron|ATP11A_ENST00000283558.8_Missense_Mutation_p.K1111N			P98196	AT11A_HUMAN	ATPase, class VI, type 11A	1111					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(12)|lung(17)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	51	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				CTAAGACTAAGAGCCAGTGCC	0.527000													30	66					0	0	1	0	0
BRD4	23476	broad.mit.edu	37	19	15355563	15355563	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:15355563C>T	ENST00000263377.2	-	12	2390	c.2169G>A	c.(2167-2169)ccG>ccA	p.P723P		NM_058243.2	NP_490597.1	O60885	BRD4_HUMAN	bromodomain containing 4	723					interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding	p.P723P(1)		breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|urinary_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			TTTTTGACTTCGGAGCCATCT	0.567000			T	C15orf55	lethal midline carcinoma of young people								34	172					0	0	1	0	0
AURKAIP1	54998	broad.mit.edu	37	1	1309762	1309762	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:1309762C>G	ENST00000338370.3	-	2	516	c.116G>C	c.(115-117)aGc>aCc	p.S39T	AURKAIP1_ENST00000378853.3_Missense_Mutation_p.S39T|AURKAIP1_ENST00000338338.5_Missense_Mutation_p.S39T|AURKAIP1_ENST00000489799.1_5'UTR|AURKAIP1_ENST00000321751.5_Missense_Mutation_p.S39T			Q9NWT8	AKIP_HUMAN	aurora kinase A interacting protein 1	39					negative regulation of mitosis|positive regulation of proteolysis	mitochondrion|nucleus	protein binding			kidney(1)|lung(2)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;5.82e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		CGGCGATGTGCTGTAAAGGGG	0.706000													7	9					0	0	1	0	0
FAM198B	51313	broad.mit.edu	37	4	159091596	159091596	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:159091596A>G	ENST00000592057.1	-	2	1334	c.932T>C	c.(931-933)gTt>gCt	p.V311A	FAM198B_ENST00000585682.1_Intron|FAM198B_ENST00000296530.8_Intron|FAM198B_ENST00000589306.1_Intron|FAM198B_ENST00000393807.5_Intron			Q6UWH4	F198B_HUMAN	family with sequence similarity 198, member B	0						Golgi membrane|integral to membrane				haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(14)|skin(2)|urinary_tract(1)	26						GCTGCAAATAACGAAGCATGT	0.468000													23	39					0	0	1	0	0
NCOR1	9611	broad.mit.edu	37	17	15942889	15942889	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:15942889G>A	ENST00000268712.3	-	44	7070	c.6813C>T	c.(6811-6813)ctC>ctT	p.L2271L	NCOR1_ENST00000395857.3_Silent_p.L855L|NCOR1_ENST00000395851.1_Silent_p.L2168L	NM_006311.3	NP_006302.2	O75376	NCOR1_HUMAN	nuclear receptor corepressor 1	2271	ID2 (By similarity).|Interaction with C1D (By similarity).				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(26)|ovary(1)|prostate(7)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(10)	107				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		AGCTTCCCATGAGAGCCTTCC	0.473000													11	31					0	0	1	0	0
TMPRSS2	7113	broad.mit.edu	37	21	42840425	42840425	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr21:42840425G>A	ENST00000398585.3	-	12	1383	c.1323C>T	c.(1321-1323)ctC>ctT	p.L441L	TMPRSS2_ENST00000332149.5_Silent_p.L404L|TMPRSS2_ENST00000458356.1_Silent_p.L404L	NM_001135099.1	NP_001128571.1	O15393	TMPS2_HUMAN	transmembrane protease, serine 2	404	Peptidase S1.				proteolysis	cytoplasm|extracellular region|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity		TMPRSS2/ETV1(34)|TMPRSS2/ETV5_ENST00000306376(5)|TMPRSS2/ERG(3582)|TMPRSS2/ETV4(13)	central_nervous_system(1)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	4		Prostate(19;4.48e-07)|all_epithelial(19;0.031)				GTGTCTCAATGAGAAGCACCT	0.542000			T	"""ERG, ETV1, ETV4, ETV5"""	prostate								29	45					0	0	1	0	0
DSG1	1828	broad.mit.edu	37	18	28916515	28916515	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr18:28916515G>A	ENST00000257192.4	+	9	1416	c.1204G>A	c.(1204-1206)Gat>Aat	p.D402N		NM_001942.2	NP_001933.2	Q02413	DSG1_HUMAN	desmoglein 1	402	Cadherin 4.				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			NS(2)|central_nervous_system(2)|endometrium(5)|kidney(7)|large_intestine(11)|lung(36)|ovary(3)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	76			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			GGGATCAAATGATAAAGTGGG	0.383000													12	43					0	0	1	0	0
LIPC	3990	broad.mit.edu	37	15	58855765	58855765	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:58855765G>C	ENST00000414170.3	+	9	1518	c.1231G>C	c.(1231-1233)Ggc>Cgc	p.G411R	LIPC_ENST00000356113.6_Missense_Mutation_p.G411R|LIPC_ENST00000299022.5_Missense_Mutation_p.G411R|LIPC_ENST00000433326.2_Missense_Mutation_p.G350R			P11150	LIPC_HUMAN	lipase, hepatic	411	PLAT.				cholesterol homeostasis|chylomicron remnant clearance|fatty acid biosynthetic process|high-density lipoprotein particle remodeling|intermediate-density lipoprotein particle remodeling|low-density lipoprotein particle remodeling|phosphatidylcholine catabolic process|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle	apolipoprotein binding|heparin binding|low-density lipoprotein particle binding|phospholipase activity|triglyceride lipase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Colorectal(260;0.215)		GBM - Glioblastoma multiforme(80;0.00213)|all cancers(107;0.00548)		TGTGGATATCGGCGAGCTGAT	0.468000													31	139					0	0	1	0	0
KIAA1279	26128	broad.mit.edu	37	10	70748916	70748916	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:70748916G>A	ENST00000361983.4	+	1	430	c.328G>A	c.(328-330)Gag>Aag	p.E110K		NM_015634.3	NP_056449.1	Q96EK5	KBP_HUMAN	KIAA1279	110					cell differentiation|mitochondrial transport|nervous system development	mitochondrion	kinesin binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(1)	14						CGACACGGAGGAGCTGTCGGC	0.682000													31	35					0	0	1	0	0
DSCAML1	57453	broad.mit.edu	37	11	117392001	117392001	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:117392001C>T	ENST00000321322.6	-	6	1238	c.1237G>A	c.(1237-1239)Gag>Aag	p.E413K	DSCAML1_ENST00000527706.1_Missense_Mutation_p.E143K	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	353	Ig-like C2-type 5.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		AGCACCAGCTCCGTGTTGCGA	0.627000													100	81					0	0	1	0	0
COQ5	84274	broad.mit.edu	37	12	120947870	120947870	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:120947870C>G	ENST00000288532.6	-	4	671	c.631G>C	c.(631-633)Gat>Cat	p.D211H	COQ5_ENST00000445328.2_Missense_Mutation_p.D137H	NM_032314.3	NP_115690.3	Q5HYK3	COQ5_HUMAN	coenzyme Q5 homolog, methyltransferase (S. cerevisiae)	211					ubiquinone biosynthetic process	mitochondrion	methyltransferase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(1)|prostate(1)|urinary_tract(3)	20	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GTGTAAATATCAAACTTGTCA	0.448000													38	59					0	0	1	0	0
TIAM2	26230	broad.mit.edu	37	6	155451298	155451298	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:155451298C>T	ENST00000461783.3	+	6	2214	c.941C>T	c.(940-942)tCa>tTa	p.S314L	TIAM2_ENST00000529824.2_Missense_Mutation_p.S314L|TIAM2_ENST00000367174.2_5'UTR|TIAM2_ENST00000360366.4_Missense_Mutation_p.S314L|TIAM2_ENST00000456144.1_Missense_Mutation_p.S314L|TIAM2_ENST00000318981.5_Missense_Mutation_p.S314L			Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	314					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		CTCTCCCCCTCAGGTATCCGC	0.557000													21	30					0	0	1	0	0
SLC8A2	6543	broad.mit.edu	37	19	47933517	47933517	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:47933517G>A	ENST00000236877.6	-	10	2990	c.2595C>T	c.(2593-2595)ttC>ttT	p.F865F	SLC8A2_ENST00000542837.1_Silent_p.F621F|SLC8A2_ENST00000539381.1_Silent_p.F328F	NM_015063.2	NP_055878.1	Q9UPR5	NAC2_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 2	865					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|skin(5)|stomach(1)	31		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		CCACGAAGGCGAAGACGGTGA	0.726000													7	23					0	0	1	0	0
NOD2	64127	broad.mit.edu	37	16	50733855	50733855	+	Missense_Mutation	SNP	C	C	T	rs144368009		TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:50733855C>T	ENST00000300589.2	+	2	635	c.530C>T	c.(529-531)cCg>cTg	p.P177L	NOD2_ENST00000526417.2_3'UTR	NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	177	CARD 2.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				ATCTTCACACCGTCCCAGAGG	0.542000													4	71					0	0	1	0	0
MANSC1	54682	broad.mit.edu	37	12	12483694	12483694	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:12483694A>G	ENST00000535902.1	-	4	1126	c.563T>C	c.(562-564)aTg>aCg	p.M188T	MANSC1_ENST00000545735.1_Missense_Mutation_p.M107T|MANSC1_ENST00000396349.3_Missense_Mutation_p.M154T			Q9H8J5	MANS1_HUMAN	MANSC domain containing 1	188						integral to membrane				breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|skin(1)|stomach(4)	23		Prostate(47;0.0865)		BRCA - Breast invasive adenocarcinoma(232;0.185)		TGCTTCATCCATCTTAAATAG	0.418000													21	38					0	0	1	0	0
CCER1	196477	broad.mit.edu	37	12	91347544	91347544	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:91347544C>T	ENST00000358859.2	-	1	1409	c.976G>A	c.(976-978)Gaa>Aaa	p.E326K	CCER1_ENST00000548187.1_Intron	NM_152638.2	NP_689851.1			coiled-coil glutamate-rich protein 1																		tccacatattcagcctcttcg	0.547000													10	23					0	0	1	0	0
STAT2	6773	broad.mit.edu	37	12	56749506	56749506	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:56749506G>A	ENST00000314128.4	-	4	390	c.367C>T	c.(367-369)Cag>Tag	p.Q123*	STAT2_ENST00000418572.2_Nonsense_Mutation_p.Q119*|STAT2_ENST00000557235.1_Nonsense_Mutation_p.Q119*			P52630	STAT2_HUMAN	signal transducer and activator of transcription 2, 113kDa	123					interspecies interaction between organisms|JAK-STAT cascade|regulation of transcription from RNA polymerase II promoter|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	cytosol|nucleoplasm|plasma membrane	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			NS(1)|endometrium(2)|kidney(5)|large_intestine(7)|liver(2)|lung(10)|ovary(1)|skin(3)	31						TGGGCCCTCTGAGCCTGGATC	0.453000													44	74					0	0	1	0	0
PALD1	27143	broad.mit.edu	37	10	72300935	72300935	+	Silent	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:72300935C>A	ENST00000263563.6	+	16	2254	c.1986C>A	c.(1984-1986)ctC>ctA	p.L662L		NM_014431.2	NP_055246.2			phosphatase domain containing, paladin 1																		TCAGCTGCCTCAGCGGCCAGG	0.607000													62	67					1.80625e-27	1.95249e-27	1	1	0
A2M	2	broad.mit.edu	37	12	9242527	9242527	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:9242527C>G	ENST00000318602.7	-	21	2996	c.2689G>C	c.(2689-2691)Gac>Cac	p.D897H		NM_000014.4	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin	897					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(17)|lung(30)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	77					Bacitracin(DB00626)|Becaplermin(DB00102)	ATGACTGTGTCTTTCCTTCCG	0.378000													16	42					0	0	1	0	0
RERE	473	broad.mit.edu	37	1	8585829	8585829	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:8585829G>A	ENST00000377464.1	-	1	169	c.15C>T	c.(13-15)ttC>ttT	p.F5F	RERE_ENST00000337907.3_Intron|RERE_ENST00000400907.2_Intron|RERE_ENST00000400908.2_Intron			Q9P2R6	RERE_HUMAN	arginine-glutamic acid dipeptide (RE) repeats	0					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(16)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		TGCAGGGGCTGAATGGATCAT	0.463000													8	20					0	0	1	0	0
MRPS24	64951	broad.mit.edu	37	7	43908565	43908565	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:43908565T>C	ENST00000317534.5	-	3	278	c.217A>G	c.(217-219)Aca>Gca	p.T73A	MRPS24_ENST00000467084.1_5'UTR|URGCP-MRPS24_ENST00000603700.1_3'UTR	NM_032014.2	NP_114403.1	Q96EL2	RT24_HUMAN	mitochondrial ribosomal protein S24	73					translation	mitochondrial large ribosomal subunit|mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome			large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	5						CGCTCACCTGTGTGCAGCGAC	0.557000													52	71					0	0	1	0	0
NUP214	8021	broad.mit.edu	37	9	134026095	134026095	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:134026095G>A	ENST00000359428.5	+	16	2364	c.2220G>A	c.(2218-2220)ctG>ctA	p.L740L	NUP214_ENST00000411637.2_Silent_p.L730L|RP11-544A12.4_ENST00000589667.1_RNA|RP11-544A12.4_ENST00000415391.2_RNA|RP11-544A12.4_ENST00000588378.1_RNA|NUP214_ENST00000451030.1_Silent_p.L741L|RP11-544A12.4_ENST00000587264.1_RNA|RP11-544A12.4_ENST00000586290.1_RNA|RP11-544A12.4_ENST00000590461.1_RNA|RP11-544A12.4_ENST00000587408.1_RNA|RP11-544A12.4_ENST00000589540.1_RNA			P35658	NU214_HUMAN	nucleoporin 214kDa	740	11 X 5 AA approximate repeats.|Leucine-zipper 1.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			NS(1)|breast(9)|central_nervous_system(3)|endometrium(13)|kidney(2)|large_intestine(9)|liver(2)|lung(29)|ovary(2)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	86	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		TGAAGATGCTGCGAACAGAAT	0.408000			T	"""DEK, SET, ABL1"""	"""AML, T-ALL"""								28	100					0	0	1	0	0
CHD7	55636	broad.mit.edu	37	8	61754499	61754499	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:61754499G>A	ENST00000423902.2	+	21	5217	c.4738G>A	c.(4738-4740)Gaa>Aaa	p.E1580K	CHD7_ENST00000524602.1_Intron	NM_017780.3	NP_060250.2	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	1580					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(8)|cervix(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(16)|lung(49)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(3)	123		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			CTCAGACTTGGAAAGTGATTC	0.468000													5	17					0	0	1	0	0
CRNKL1	51340	broad.mit.edu	37	20	20023021	20023021	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:20023021C>T	ENST00000377340.2	-	9	1626	c.1595G>A	c.(1594-1596)cGc>cAc	p.R532H	CRNKL1_ENST00000377327.4_Missense_Mutation_p.R520H|CRNKL1_ENST00000536226.1_Missense_Mutation_p.R371H	NM_001278628.1|NM_016652.4	NP_001265557.1|NP_057736.4	Q9BZJ0	CRNL1_HUMAN	crooked neck pre-mRNA splicing factor 1	532					spliceosome assembly	catalytic step 2 spliceosome|cytoplasm|nuclear speck	RNA binding			breast(2)|cervix(2)|endometrium(7)|large_intestine(11)|lung(12)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(6)	45						ATAAATGTAGCGCTTCCAGTG	0.448000													48	75					0	0	1	0	0
GPR39	2863	broad.mit.edu	37	2	133174626	133174626	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:133174626C>T	ENST00000329321.3	+	1	480	c.11C>T	c.(10-12)cCc>cTc	p.P4L		NM_001508.2	NP_001499.1	O43194	GPR39_HUMAN	G protein-coupled receptor 39	4						integral to plasma membrane	G-protein coupled receptor activity|metal ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						ATGGCTTCACCCAGCCTCCCG	0.517000													28	51					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9288501	9288501	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:9288501C>T	ENST00000378501.2	+	1	55	c.40C>T	c.(40-42)Ccc>Tcc	p.P14S	PLCB4_ENST00000334005.3_Missense_Mutation_p.P14S|PLCB4_ENST00000414679.2_Missense_Mutation_p.P14S|PLCB4_ENST00000378493.1_Missense_Mutation_p.P14S|PLCB4_ENST00000378473.3_Missense_Mutation_p.P14S|PLCB4_ENST00000278655.4_Missense_Mutation_p.P14S|PLCB4_ENST00000492632.1_3'UTR	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	14					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						GAAGGAAGTTCCCTCCTTTTT	0.299000													12	28					0	0	1	0	0
PNMA1	9240	broad.mit.edu	37	14	74179620	74179620	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:74179620C>T	ENST00000316836.3	-	1	1508	c.723G>A	c.(721-723)gaG>gaA	p.E241E		NM_006029.4	NP_006020.4	Q8ND90	PNMA1_HUMAN	paraneoplastic Ma antigen 1	241					apoptosis|central nervous system development|inflammatory response to antigenic stimulus|spermatogenesis	cytoplasm|focal adhesion|nucleolus	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|prostate(1)|urinary_tract(2)	13				BRCA - Breast invasive adenocarcinoma(234;0.00331)|KIRC - Kidney renal clear cell carcinoma(182;0.0797)		ccctagagctctcaacgctcc	0.517000													33	99					0	0	1	0	0
TNS1	7145	broad.mit.edu	37	2	218758162	218758162	+	Splice_Site	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:218758162C>A	ENST00000171887.4	-	8	794	c.342G>T	c.(340-342)aaG>aaT	p.K114N	TNS1_ENST00000419504.1_Splice_Site_p.K114N|TNS1_ENST00000430930.1_Splice_Site_p.K114N|TNS1_ENST00000310858.6_Splice_Site_p.K145N	NM_022648.4	NP_072174.3	Q9HBL0	TENS1_HUMAN	tensin 1	114	Phosphatase tensin-type.					cytoplasm|cytoskeleton|focal adhesion	actin binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(23)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	79		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		caGCTCTGACCTTGTTGTGTA	0.537000													3	59					1	1	1	1	0
PFKFB2	5208	broad.mit.edu	37	1	207241622	207241622	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:207241622G>A	ENST00000367080.3	+	10	1079	c.955G>A	c.(955-957)Gag>Aag	p.E319K	PFKFB2_ENST00000411990.2_Missense_Mutation_p.E221K|PFKFB2_ENST00000545806.1_Missense_Mutation_p.E286K|PFKFB2_ENST00000541914.1_Missense_Mutation_p.E133K|PFKFB2_ENST00000367079.2_Missense_Mutation_p.E319K	NM_006212.2	NP_006203.2	O60825	F262_HUMAN	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	319	Fructose-2,6-bisphosphatase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	20	Prostate(682;0.19)					GGTGCCCTATGAGCAGTGGAA	0.473000													17	12					0	0	1	0	0
MAGI3	260425	broad.mit.edu	37	1	114226131	114226131	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:114226131G>A	ENST00000307546.9	+	21	4016	c.3941G>A	c.(3940-3942)cGa>cAa	p.R1314Q	MAGI3_ENST00000369615.1_3'UTR	NM_001142782.1	NP_001136254.1	Q5TCQ9	MAGI3_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 3	1339					apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(9)|ovary(3)|prostate(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	41	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGTAAGAGTCGAAGAATAGCA	0.453000													31	69					0	0	1	0	0
HOXB1	3211	broad.mit.edu	37	17	46607930	46607930	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:46607930G>C	ENST00000239174.6	-	1	429	c.337C>G	c.(337-339)Ccc>Gcc	p.P113A	HOXB1_ENST00000577092.1_Missense_Mutation_p.P113A	NM_002144.3	NP_002135.2	P14653	HXB1_HUMAN	homeobox B1	113						nucleus	protein domain specific binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						TAGCTCGAGGGATGAAAATAG	0.642000													25	146					0	0	1	0	0
SLC5A7	60482	broad.mit.edu	37	2	108608587	108608587	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:108608587C>T	ENST00000264047.2	+	3	480	c.204C>T	c.(202-204)atC>atT	p.I68I	SLC5A7_ENST00000540517.1_5'UTR|SLC5A7_ENST00000409059.1_Silent_p.I68I	NM_021815.2	NP_068587.1	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (sodium/choline cotransporter), member 7	68					acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity	p.I68I(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(23)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	49					Choline(DB00122)	GAGGGTATATCAATGGCACAG	0.458000													34	75					0	0	1	0	0
CBR3-AS1	100506428	broad.mit.edu	37	21	37504755	37504755	+	RNA	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr21:37504755C>T	ENST00000413862.1	-	0	871				CBR3-AS1_ENST00000453159.1_RNA	NR_038892.1																						AACATGCCAGCGGCCCAGAGC	0.478000													4	10					0	0	1	0	0
PER3	8863	broad.mit.edu	37	1	7887376	7887376	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:7887376C>T	ENST00000377532.3	+	17	2611	c.2387C>T	c.(2386-2388)gCc>gTc	p.A796V	RP3-467L1.4_ENST00000451646.1_RNA|PER3_ENST00000361923.2_Missense_Mutation_p.A788V			P56645	PER3_HUMAN	period circadian clock 3	788	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			breast(4)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	39	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		TTCCCACCTGCCGCCATGGTG	0.701000													46	85					0	0	1	0	0
RLF	6018	broad.mit.edu	37	1	40705282	40705282	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:40705282C>G	ENST00000372771.4	+	8	4935	c.4908C>G	c.(4906-4908)atC>atG	p.I1636M		NM_012421.3	NP_036553.2	Q13129	RLF_HUMAN	rearranged L-myc fusion	1636					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(18)|lung(18)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(4)|urinary_tract(2)	68	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			GTGCACCCATCCAGAACACTG	0.468000													37	57					0	0	1	0	0
KIF13A	63971	broad.mit.edu	37	6	17809073	17809073	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:17809073C>T	ENST00000378814.5	-	18	2088	c.2089G>A	c.(2089-2091)Gag>Aag	p.E697K	KIF13A_ENST00000378816.5_Missense_Mutation_p.E697K|KIF13A_ENST00000378843.2_Missense_Mutation_p.E697K|KIF13A_ENST00000259711.6_Missense_Mutation_p.E697K|KIF13A_ENST00000378826.2_Missense_Mutation_p.E697K	NM_001105568.2	NP_001099038.1	Q9H1H9	KI13A_HUMAN	kinesin family member 13A	697					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	64	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			CTCATTTCCTCAGCCAGGAAG	0.488000													23	35					0	0	1	0	0
MRPS17	51373	broad.mit.edu	37	7	56022758	56022758	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:56022758C>T	ENST00000285298.4	+	3	409	c.280C>T	c.(280-282)Cca>Tca	p.P94S	MRPS17_ENST00000426595.1_Missense_Mutation_p.P189S	NM_015969.2	NP_057053.1	Q9Y2R5	RT17_HUMAN	mitochondrial ribosomal protein S17	94					translation	mitochondrial small ribosomal subunit	rRNA binding|structural constituent of ribosome			kidney(1)|large_intestine(2)|lung(4)|urinary_tract(1)	8	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			AGTCATAGATCCAGTGACAGG	0.458000													29	90					0	0	1	0	0
SRRM4	84530	broad.mit.edu	37	12	119583320	119583320	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:119583320C>T	ENST00000267260.4	+	9	1294	c.906C>T	c.(904-906)gcC>gcT	p.A302A		NM_194286.3	NP_919262.2	A7MD48	SRRM4_HUMAN	serine/arginine repetitive matrix 4	302	Ser-rich.				cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	24						CCAGCTCAGCCAGGTCTCGGG	0.622000													3	17					0	0	1	0	0
TAF6L	10629	broad.mit.edu	37	11	62554200	62554200	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:62554200C>T	ENST00000294168.3	+	11	1502	c.1301C>T	c.(1300-1302)tCg>tTg	p.S434L	TMEM223_ENST00000527073.1_Intron|RP11-727F15.12_ENST00000601484.1_RNA	NM_006473.3	NP_006464.1	Q9Y6J9	TAF6L_HUMAN	TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa	434					chromatin remodeling|histone H3 acetylation|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	histone deacetylase complex|STAGA complex	DNA binding|protein binding|transcription coactivator activity			endometrium(2)|large_intestine(5)|lung(4)|ovary(3)|prostate(1)|skin(1)	16						CCTTCTCTTTCGGTGACCCTG	0.692000											OREG0021030	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	45					0	0	1	0	0
PRRG1	5638	broad.mit.edu	37	X	37312442	37312442	+	Silent	SNP	A	A	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chrX:37312442A>T	ENST00000542554.1	+	5	497	c.225A>T	c.(223-225)ggA>ggT	p.G75G	PRRG1_ENST00000491253.1_3'UTR|PRRG1_ENST00000378628.4_Silent_p.G75G|PRRG1_ENST00000449135.2_Silent_p.G75G|TM4SF2_ENST00000465127.1_Intron|PRRG1_ENST00000543642.1_Silent_p.G75G	NM_001173489.1	NP_001166960.1	O14668	TMG1_HUMAN	proline rich Gla (G-carboxyglutamic acid) 1	75						extracellular region|integral to plasma membrane	calcium ion binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	15						GTAACCGAGGAAGTGACTGGT	0.373000													27	9					0	0	1	0	0
UVSSA	57654	broad.mit.edu	37	4	1377693	1377693	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:1377693C>T	ENST00000389851.4	+	13	2448	c.2001C>T	c.(1999-2001)acC>acT	p.T667T	UVSSA_ENST00000511563.1_Silent_p.T218T|UVSSA_ENST00000507531.1_Silent_p.T667T|UVSSA_ENST00000512728.1_Silent_p.T218T|UVSSA_ENST00000511216.1_Silent_p.T667T	NM_020894.2	NP_065945.2	Q2YD98	K1530_HUMAN	UV-stimulated scaffold protein A	667																	AGGCTGATACCGCCCGCGCTC	0.642000													14	67					0	0	1	0	0
CIRH1A	84916	broad.mit.edu	37	16	69202805	69202805	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:69202805C>T	ENST00000314423.7	+	17	2203	c.2026C>T	c.(2026-2028)Cca>Tca	p.P676S	CIRH1A_ENST00000352319.4_Missense_Mutation_p.P561S			Q969X6	CIR1A_HUMAN	cirrhosis, autosomal recessive 1A (cirhin)	676						nucleolus	protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(4)|prostate(1)|urinary_tract(1)	16				OV - Ovarian serous cystadenocarcinoma(108;0.125)		TGCTCAGCTCCCACCACCCAT	0.443000													4	141					0	0	1	0	0
MYO7A	4647	broad.mit.edu	37	11	76903243	76903243	+	Missense_Mutation	SNP	T	T	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:76903243T>A	ENST00000409709.3	+	31	4344	c.4072T>A	c.(4072-4074)Tcc>Acc	p.S1358T	MYO7A_ENST00000409619.2_Missense_Mutation_p.S1347T|MYO7A_ENST00000458637.2_Missense_Mutation_p.S1358T	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	1358	FERM 1.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						GCACAGCCCCTCCGAGGACAA	0.622000											OREG0021258	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	79	107					0	0	1	0	0
SPATA31D1	389763	broad.mit.edu	37	9	84609239	84609239	+	Missense_Mutation	SNP	C	C	T	rs115598379	by1000genomes	TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:84609239C>T	ENST00000344803.2	+	4	3901	c.3854C>T	c.(3853-3855)aCg>aTg	p.T1285M		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		TGTCAAGTTACGAATTTCCCA	0.562000													13	22					0	0	1	0	0
BRAP	8315	broad.mit.edu	37	12	112087755	112087755	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:112087755G>A	ENST00000419234.4	-	11	1596	c.1403C>T	c.(1402-1404)tCt>tTt	p.S468F	BRAP_ENST00000327551.6_Missense_Mutation_p.S438F|BRAP_ENST00000539060.1_Missense_Mutation_p.S289F	NM_006768.3	NP_006759.3	Q7Z569	BRAP_HUMAN	BRCA1 associated protein	468					MAPKKK cascade|negative regulation of signal transduction|Ras protein signal transduction	cytoplasm|ubiquitin ligase complex	identical protein binding|nuclear localization sequence binding|nucleotide binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	20						TCTTTCCACAGACTGCTTTTC	0.338000													3	38					0	0	1	0	0
OCA2	4948	broad.mit.edu	37	15	28326981	28326981	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:28326981C>T	ENST00000354638.3	-	2	195	c.40G>A	c.(40-42)Gcg>Acg	p.A14T	OCA2_ENST00000353809.5_Missense_Mutation_p.A14T|OCA2_ENST00000382996.2_Missense_Mutation_p.A14T	NM_000275.2	NP_000266.2	Q04671	P_HUMAN	oculocutaneous albinism II	14					eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(48)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		ACCGCCGGCGCGCCGGGGTAC	0.657000									Oculocutaneous Albinism				12	30					0	0	1	0	0
DDX5	1655	broad.mit.edu	37	17	62499341	62499341	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:62499341C>T	ENST00000225792.5	-	7	1176	c.775G>A	c.(775-777)Gaa>Aaa	p.E259K	DDX5_ENST00000450599.2_Missense_Mutation_p.E180K|DDX5_ENST00000578804.1_Missense_Mutation_p.E259K	NM_004396.3	NP_004387.1	P17844	DDX5_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 5	259	Helicase ATP-binding.				cell growth|regulation of alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|mRNA binding|protein binding|RNA helicase activity|transcription cofactor activity			breast(3)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)	19	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;8.6e-12)			ATTTGGGGTTCAAAGCCCATA	0.363000			T	ETV4	prostate								20	92					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37430773	37430773	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:37430773G>A	ENST00000374660.1	+	7	879	c.780G>A	c.(778-780)acG>acA	p.T260T	ANKRD30A_ENST00000602533.1_Silent_p.T260T|ANKRD30A_ENST00000361713.1_Silent_p.T260T			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	316						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						CACCTGACACGGCTGAAAGCT	0.493000													3	71					0	0	1	0	0
FADS1	3992	broad.mit.edu	37	11	61570834	61570834	+	Splice_Site	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:61570834C>T	ENST00000350997.7	-	9	1481		c.e9+1		FADS1_ENST00000536991.1_Splice_Site|FADS1_ENST00000542506.1_Splice_Site|FADS2_ENST00000574708.1_Intron|FADS1_ENST00000460649.1_Splice_Site|FADS1_ENST00000433932.1_Splice_Site	NM_013402.4	NP_037534.3	O60427	FADS1_HUMAN	fatty acid desaturase 1						cell-cell signaling|cellular response to starvation|electron transport chain|icosanoid biosynthetic process|phospholipid biosynthetic process|regulation of cell differentiation|regulation of transcription, DNA-dependent|transport	endoplasmic reticulum membrane|integral to membrane|microsome	C-5 sterol desaturase activity|heme binding|protein binding			central_nervous_system(1)|endometrium(1)|lung(1)|urinary_tract(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	CTGTCCCTTACCTGGGTGGAA	0.458000													78	196					0	0	1	0	0
ANO8	57719	broad.mit.edu	37	19	17440802	17440802	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:17440802G>C	ENST00000159087.4	-	11	1453	c.1295C>G	c.(1294-1296)gCc>gGc	p.A432G		NM_020959.2	NP_066010.1	Q9HCE9	ANO8_HUMAN	anoctamin 8	432	Leu-rich.					chloride channel complex	chloride channel activity			autonomic_ganglia(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(3)	27						CTTCTCATAGGCGCTCTCCAG	0.627000													30	122					0	0	1	0	0
COG4	25839	broad.mit.edu	37	16	70531255	70531255	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:70531255C>T	ENST00000323786.5	-	11	1371	c.1350G>A	c.(1348-1350)ctG>ctA	p.L450L		NM_001195139.1|NM_015386.2	NP_001182068.1|NP_056201.2	Q9H9E3	COG4_HUMAN	component of oligomeric golgi complex 4	446					Golgi organization|Golgi vesicle prefusion complex stabilization|protein transport|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(12)|pancreas(1)|prostate(2)	33		Ovarian(137;0.0694)				TGCTGGATGTCAGCTGGCCCT	0.512000													91	114					0	0	1	0	0
TRMT6	51605	broad.mit.edu	37	20	5924896	5924896	+	Missense_Mutation	SNP	T	T	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:5924896T>A	ENST00000203001.2	-	4	500	c.370A>T	c.(370-372)Ata>Tta	p.I124L	TRMT6_ENST00000453074.2_5'UTR|TRMT6_ENST00000473131.1_5'UTR	NM_015939.3	NP_057023.2	Q9UJA5	TRM6_HUMAN	tRNA methyltransferase 6 homolog (S. cerevisiae)	124					regulation of translational initiation|tRNA processing	nucleus	protein binding|translation initiation factor activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(2)|lung(5)|pancreas(1)	15						TGCTGAACTATTTCCTATAAG	0.308000													12	17					0	0	1	0	0
PKNOX2	63876	broad.mit.edu	37	11	125280125	125280125	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:125280125G>C	ENST00000298282.9	+	8	893	c.622G>C	c.(622-624)Gga>Cga	p.G208R	PKNOX2_ENST00000542175.1_Missense_Mutation_p.G144R|PKNOX2_ENST00000530517.1_3'UTR	NM_022062.2	NP_071345.2	Q96KN3	PKNX2_HUMAN	PBX/knotted 1 homeobox 2	208						nucleus	sequence-specific DNA binding transcription factor activity	p.G208R(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(14)|ovary(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	29		Breast(109;0.00234)|all_lung(97;0.0191)|Lung NSC(97;0.0196)|Medulloblastoma(222;0.0447)|all_neural(223;0.116)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.117)		TTCCATGTCCGGAGTCTCCAA	0.572000													108	217					0	0	1	0	0
KLK8	11202	broad.mit.edu	37	19	51499316	51499316	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:51499316C>T	ENST00000600767.1	-	7	1271	c.782G>A	c.(781-783)tGa>tAa	p.*261*	KLK8_ENST00000291726.7_Silent_p.*261*|CTB-147C22.9_ENST00000594512.1_RNA|KLK8_ENST00000593490.1_3'UTR|KLK8_ENST00000347619.4_Silent_p.*120*|KLK8_ENST00000391806.2_Silent_p.*306*|KLK8_ENST00000320838.5_3'UTR			O60259	KLK8_HUMAN	kallikrein-related peptidase 8	0					cell death|keratinocyte proliferation|memory|negative regulation of axon regeneration|negative regulation of myelination|neuron projection morphogenesis|proteolysis|regulation of synapse organization|response to wounding	cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(8)|prostate(1)	15		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.0033)|GBM - Glioblastoma multiforme(134;0.00888)		ATCCTAGAATCAGCCCTTGCT	0.537000													100	245					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114158209	114158209	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:114158209G>C	ENST00000357077.4	+	6	603	c.550G>C	c.(550-552)Gag>Cag	p.E184Q	ANK2_ENST00000394537.3_Missense_Mutation_p.E184Q|ANK2_ENST00000506722.1_Missense_Mutation_p.E163Q|ANK2_ENST00000264366.6_Missense_Mutation_p.E184Q	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	184					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CATCCTCTTGGAGAATGACAC	0.498000													44	176					0	0	1	0	0
ERCC6L2	375748	broad.mit.edu	37	9	98660185	98660185	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:98660185G>C	ENST00000288985.7	+	3	864	c.559G>C	c.(559-561)Gaa>Caa	p.E187Q	ERCC6L2_ENST00000466840.1_3'UTR	NM_001010895.2	NP_001010895.1	Q5T890	RAD26_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6-like 2	187	Helicase ATP-binding.				DNA repair	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding										TGAGGATATTGAAAATAACAT	0.333000													20	65					0	0	1	0	0
CCDC39	339829	broad.mit.edu	37	3	180397147	180397147	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:180397147C>T	ENST00000273654.4	-	7	893	c.274G>A	c.(274-276)Gag>Aag	p.E92K	CCDC39_ENST00000442201.2_Missense_Mutation_p.E8K			Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	8					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				NS(1)|breast(1)|endometrium(4)|large_intestine(9)|lung(22)|ovary(6)|prostate(2)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			CAGTGCAGCTCAGCCAGGAAT	0.557000													140	194					0	0	1	0	0
PRSS3P2	154754	broad.mit.edu	37	7	142479940	142479940	+	RNA	SNP	C	C	T	rs58649169	by1000genomes	TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:142479940C>T	ENST00000603901.1	+	0	72					NR_001296.3																						ATGACAAGATCGTTGGGGGCT	0.557000													4	68					0	0	1	0	0
MTX3	345778	broad.mit.edu	37	5	79279583	79279583	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:79279583G>A	ENST00000512560.1	-	8	799	c.680C>T	c.(679-681)cCt>cTt	p.P227L	MTX3_ENST00000512528.1_Missense_Mutation_p.P288L|MTX3_ENST00000509852.1_3'UTR	NM_001167741.1	NP_001161213.1	Q5HYI7	MTX3_HUMAN	metaxin 3	288					protein targeting to mitochondrion	mitochondrial outer membrane				endometrium(1)|large_intestine(3)|lung(2)|urinary_tract(1)	7		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.63e-45)|Epithelial(54;2.9e-40)|all cancers(79;4.68e-35)		TTTCCGAGGAGGAAGCTGAGG	0.468000													32	51					0	0	1	0	0
TEDDM1	127670	broad.mit.edu	37	1	182368982	182368982	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:182368982C>T	ENST00000367565.1	-	1	769	c.639G>A	c.(637-639)ctG>ctA	p.L213L		NM_172000.3	NP_741997.3	Q5T9Z0	TEDM1_HUMAN	transmembrane epididymal protein 1	213						integral to membrane				haematopoietic_and_lymphoid_tissue(1)|lung(4)|ovary(2)	7						AGATTCCCAACAGGAATGAGG	0.488000													18	25					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124438234	124438234	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:124438234G>A	ENST00000291478.5	+	27	3950	c.3787G>A	c.(3787-3789)Gaa>Aaa	p.E1263K	KALRN_ENST00000360013.3_Missense_Mutation_p.E2960K|KALRN_ENST00000428018.2_Missense_Mutation_p.E1231K	NM_007064.3	NP_008995.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase						apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						ATGCTTCATAGAACGTCGCAA	0.562000													25	105					0	0	1	0	0
CD2AP	23607	broad.mit.edu	37	6	47577018	47577018	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:47577018G>C	ENST00000359314.5	+	16	2248	c.1792G>C	c.(1792-1794)Gaa>Caa	p.E598Q	CD2AP_ENST00000486693.1_3'UTR	NM_012120.2	NP_036252.1	Q9Y5K6	CD2AP_HUMAN	CD2-associated protein	598					cell division|mitosis|protein complex assembly|signal transduction|substrate-dependent cell migration, cell extension	cytoplasm|filamentous actin|nucleolus|plasma membrane|ruffle	SH3 domain binding|structural constituent of cytoskeleton			kidney(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	20			Lung(136;0.105)|LUSC - Lung squamous cell carcinoma(51;0.138)			GTGCATTGTAGAAGCACTGAA	0.353000													3	150					0	0	1	0	0
NCKAP5L	57701	broad.mit.edu	37	12	50189089	50189089	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:50189089C>T	ENST00000335999.6	-	8	2755	c.2554G>A	c.(2554-2556)Gac>Aac	p.D852N		NM_001037806.3	NP_001032895.2	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	848	Pro-rich.									central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(8)|prostate(2)	18						CTACCACAGTCTGCCCAGGGA	0.647000													32	146					0	0	1	0	0
HERC1	8925	broad.mit.edu	37	15	64067652	64067652	+	Silent	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:64067652G>C	ENST00000443617.2	-	2	258	c.171C>G	c.(169-171)ctC>ctG	p.L57L		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	57					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						GTGGTCCTTTGAGGCATAAAA	0.443000													17	41					0	0	1	0	0
AP4S1	11154	broad.mit.edu	37	14	31535513	31535513	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:31535513G>A	ENST00000216366.4	+	2	319	c.111G>A	c.(109-111)aaG>aaA	p.K37K	AP4S1_ENST00000542754.2_Silent_p.K37K|AP4S1_ENST00000313566.6_Silent_p.K37K|AP4S1_ENST00000334725.4_Silent_p.K37K|AP4S1_ENST00000554345.1_Silent_p.K37K|AP4S1_ENST00000554609.1_Silent_p.K37K	NM_007077.4	NP_009008.2	Q9Y587	AP4S1_HUMAN	adaptor-related protein complex 4, sigma 1 subunit	37						coated pit|Golgi apparatus	protein transporter activity			lung(1)	1	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.221)	GBM - Glioblastoma multiforme(265;0.00553)		AAGTCATAAAGAGCTGTCTCT	0.393000													20	72					0	0	1	0	0
SNX8	29886	broad.mit.edu	37	7	2311494	2311494	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:2311494G>A	ENST00000222990.3	-	4	573	c.531C>T	c.(529-531)ttC>ttT	p.F177F		NM_013321.2	NP_037453.1	Q9Y5X2	SNX8_HUMAN	sorting nexin 8	177	PX.				cell communication|early endosome to Golgi transport|intracellular protein transport	early endosome membrane	phosphatidylinositol binding|protein binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(2)|skin(3)	26		Ovarian(82;0.11)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0853)|OV - Ovarian serous cystadenocarcinoma(56;3.79e-14)		CCGAGCCGCTGAAGGACAGGA	0.637000													5	10					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21479343	21479343	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr18:21479343G>A	ENST00000313654.9	+	47	6169	c.5928G>A	c.(5926-5928)atG>atA	p.M1976I	LAMA3_ENST00000587184.1_Intron|LAMA3_ENST00000269217.6_Missense_Mutation_p.M367I|LAMA3_ENST00000399516.3_Intron|LAMA3_ENST00000588770.1_3'UTR	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	1976	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCCAGCGCATGATGAGGGAAC	0.493000													16	59					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126412206	126412206	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:126412206C>A	ENST00000394329.3	+	17	14242	c.14229C>A	c.(14227-14229)ttC>ttA	p.F4743L	FAT4_ENST00000335110.5_Missense_Mutation_p.F2984L	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4743					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CTGGCATTTTCAACTATGCCA	0.498000													13	69					3.27435e-08	3.3871e-08	1	1	0
RBM15B	29890	broad.mit.edu	37	3	51429743	51429743	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:51429743G>A	ENST00000323686.4	+	1	1013	c.913G>A	c.(913-915)Gac>Aac	p.D305N		NM_013286.4	NP_037418.3	Q8NDT2	RB15B_HUMAN	RNA binding motif protein 15B	305					interspecies interaction between organisms|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nucleoplasm	nucleotide binding|protein binding|RNA binding			endometrium(4)|large_intestine(5)|lung(3)	12				BRCA - Breast invasive adenocarcinoma(193;0.000224)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		GCGGGCCCTGGACTACTACGG	0.731000													18	30					0	0	1	0	0
LINC00933	100506874	broad.mit.edu	37	15	85121450	85121450	+	RNA	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:85121450T>C	ENST00000557887.1	+	0	650					NR_038273.1|NR_038274.1																						TTTGACCCCGTGATTCTACTC	0.403000													4	14					0	0	1	0	0
ZFP42	132625	broad.mit.edu	37	4	188924151	188924151	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:188924151G>C	ENST00000326866.4	+	4	598	c.190G>C	c.(190-192)Gga>Cga	p.G64R	ZFP42_ENST00000509524.1_Missense_Mutation_p.G64R	NM_174900.3	NP_777560.2	Q96MM3	ZFP42_HUMAN	ZFP42 zinc finger protein	64					female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		TCAGGCTCTCGGAGGGGATGA	0.507000													6	47					0	0	1	0	0
BACH2	60468	broad.mit.edu	37	6	90647877	90647877	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:90647877C>T	ENST00000257749.4	-	8	2736	c.2029G>A	c.(2029-2031)Gaa>Aaa	p.E677K	BACH2_ENST00000343122.3_Missense_Mutation_p.E677K|BACH2_ENST00000537989.1_Missense_Mutation_p.E677K	NM_021813.2	NP_068585.1	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper transcription factor 2	677	Leucine-zipper.					nucleus	protein dimerization activity|sequence-specific DNA binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(18)|ovary(5)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	45		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		TTGCGGATTTCACATTCTAAA	0.458000													24	116					0	0	1	0	0
E2F8	79733	broad.mit.edu	37	11	19256466	19256466	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:19256466C>T	ENST00000527884.1	-	5	823	c.591G>A	c.(589-591)ggG>ggA	p.G197G	RP11-428C19.4_ENST00000527978.1_RNA|E2F8_ENST00000250024.4_Silent_p.G197G	NM_001256371.1|NM_001256372.1	NP_001243300.1|NP_001243301.1	A0AVK6	E2F8_HUMAN	E2F transcription factor 8	197					cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						TATTCTCCTCCCCGATGCTCT	0.428000													15	86					0	0	1	0	0
YEATS2	55689	broad.mit.edu	37	3	183432930	183432930	+	Splice_Site	SNP	A	A	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:183432930A>T	ENST00000305135.5	+	2	176		c.e2-1			NM_018023.4	NP_060493.3	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2						histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(24)|ovary(3)|prostate(2)|skin(3)	49	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			ATTGCTTCACAGTGAAGAACT	0.358000													40	39					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152640037	152640037	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:152640037C>T	ENST00000367255.5	-	85	16951	c.16350G>A	c.(16348-16350)gcG>gcA	p.A5450A	SYNE1_ENST00000423061.1_Silent_p.A5379A|SYNE1_ENST00000265368.4_Silent_p.A5450A|SYNE1_ENST00000448038.1_Silent_p.A5379A|SYNE1_ENST00000341594.5_Silent_p.A5123A	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5450					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TATCTGTCTTCGCTTTCAGCT	0.378000										HNSCC(10;0.0054)			7	38					0	0	1	0	0
SUPT6H	6830	broad.mit.edu	37	17	27010765	27010765	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:27010765C>T	ENST00000314616.6	+	17	2443	c.2160C>T	c.(2158-2160)ttC>ttT	p.F720F	SUPT6H_ENST00000347486.4_Silent_p.F720F	NM_003170.3	NP_003161.2	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog (S. cerevisiae)	720					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	Lung NSC(42;0.00431)					TACAGCAGTTCCTCTATGTGC	0.473000													19	38					0	0	1	0	0
CAMSAP1	157922	broad.mit.edu	37	9	138713796	138713796	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:138713796G>A	ENST00000389532.4	-	11	2775	c.2711C>T	c.(2710-2712)gCa>gTa	p.A904V	CAMSAP1_ENST00000312405.6_Missense_Mutation_p.A626V|CAMSAP1_ENST00000483991.1_5'UTR|CAMSAP1_ENST00000409386.3_Missense_Mutation_p.A915V	NM_015447.3	NP_056262.3	Q5T5Y3	CAMP1_HUMAN	calmodulin regulated spectrin-associated protein 1	904						cytoplasm|microtubule				breast(3)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(11)|lung(16)|ovary(3)|pancreas(1)|skin(1)	47				OV - Ovarian serous cystadenocarcinoma(145;1.4e-06)|Epithelial(140;1.11e-05)		GCGCTGCCTTGCCGACAGCGC	0.632000													41	76					0	0	1	0	0
FLAD1	80308	broad.mit.edu	37	1	154962840	154962840	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:154962840G>C	ENST00000292180.3	+	5	1712	c.1390G>C	c.(1390-1392)Gag>Cag	p.E464Q	FLAD1_ENST00000295530.2_Intron|FLAD1_ENST00000368433.1_3'UTR|FLAD1_ENST00000368428.1_Missense_Mutation_p.E5Q|FLAD1_ENST00000315144.10_Missense_Mutation_p.E367Q|FLAD1_ENST00000405236.2_Intron|FLAD1_ENST00000368432.1_Missense_Mutation_p.E367Q	NM_025207.4	NP_079483.3	Q8NFF5	FAD1_HUMAN	flavin adenine dinucleotide synthetase 1	464	FAD synthase.				FAD biosynthetic process|Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|FMN adenylyltransferase activity			endometrium(3)|kidney(4)|large_intestine(2)|lung(7)|ovary(3)|skin(3)	22	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GTTGGAAGCTGAGGGCAGCAT	0.602000													28	108					0	0	1	0	0
FAM81B	153643	broad.mit.edu	37	5	94772582	94772582	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:94772582C>T	ENST00000283357.5	+	7	911	c.865C>T	c.(865-867)Cgc>Tgc	p.R289C		NM_152548.2	NP_689761	Q96LP2	FA81B_HUMAN	family with sequence similarity 81, member B	289										central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_cancers(142;1.1e-06)|all_epithelial(76;1.48e-09)|all_lung(232;0.000696)|Lung NSC(167;0.000947)|Ovarian(225;0.00473)		all cancers(79;1.04e-16)		GGGGGATTATCGCCACGAAAT	0.398000													13	39					0	0	1	0	0
C11orf16	56673	broad.mit.edu	37	11	8947368	8947368	+	Silent	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:8947368G>C	ENST00000326053.5	-	5	952	c.846C>G	c.(844-846)ctC>ctG	p.L282L	C11orf16_ENST00000525780.1_Silent_p.L282L	NM_020643.2	NP_065694.2	Q9NQ32	CK016_HUMAN	chromosome 11 open reading frame 16	282										central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	22				Epithelial(150;4.11e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0234)		GGCAGCCACAGAGGCAGCCCT	0.592000													88	78					0	0	1	0	0
TIFA	92610	broad.mit.edu	37	4	113199085	113199085	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:113199085T>C	ENST00000361717.3	-	2	769	c.488A>G	c.(487-489)tAt>tGt	p.Y163C	TIFA_ENST00000500655.2_Missense_Mutation_p.Y163C	NM_052864.2	NP_443096.1	Q96CG3	TIFA_HUMAN	TRAF-interacting protein with forkhead-associated domain								protein binding			breast(2)|endometrium(1)|large_intestine(1)|lung(1)|skin(1)	6		Ovarian(17;0.0443)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00172)		ATAAGTGCCATACTCCGGTAT	0.428000													9	28					0	0	1	0	0
SLAIN2	57606	broad.mit.edu	37	4	48422313	48422313	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:48422313C>T	ENST00000264313.6	+	7	1950	c.1532C>T	c.(1531-1533)tCa>tTa	p.S511L	SLAIN2_ENST00000512093.1_Missense_Mutation_p.S344L	NM_020846.1	NP_065897.1	Q9P270	SLAI2_HUMAN	SLAIN motif family, member 2	511						centrosome				breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|prostate(1)	13						AGCACAGTCTCAGCAAATCCT	0.522000													57	103					0	0	1	0	0
MAP3K5	4217	broad.mit.edu	37	6	137018501	137018501	+	Silent	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:137018501G>C	ENST00000359015.4	-	5	1191	c.831C>G	c.(829-831)ctC>ctG	p.L277L		NM_005923.3	NP_005914.1	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase 5	277					activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(6)|large_intestine(6)|lung(24)|ovary(2)|prostate(1)|skin(4)|urinary_tract(4)	58	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		TGATGTCATTGAGTATAGATT	0.358000													15	100					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414280	20414280	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:20414280G>A	ENST00000380338.4	-	5	850	c.564C>T	c.(562-564)agC>agT	p.S188S	MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S185S	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	188	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S188S(1)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		TGGTActactgctgctgctgc	0.502000			T	MLL	ALL								6	162					0	0	1	0	0
DDX60L	91351	broad.mit.edu	37	4	169374324	169374324	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:169374324C>G	ENST00000511577.1	-	8	1194	c.947G>C	c.(946-948)cGa>cCa	p.R316P	DDX60L_ENST00000505890.1_Missense_Mutation_p.R316P|DDX60L_ENST00000260184.7_Missense_Mutation_p.R316P			Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	316							ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		TGTGATGACTCGAGAACAAGC	0.408000													35	39					0	0	1	0	0
KIF1B	23095	broad.mit.edu	37	1	10364665	10364665	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:10364665C>T	ENST00000377093.4	+	21	3575	c.3422C>T	c.(3421-3423)tCa>tTa	p.S1141L	KIF1B_ENST00000377086.1_Intron|KIF1B_ENST00000377081.1_Intron|KIF1B_ENST00000377083.1_Missense_Mutation_p.S1141L|KIF1B_ENST00000263934.6_Intron	NM_183416.3	NP_904325.2	O60333	KIF1B_HUMAN	kinesin family member 1B	0					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			breast(2)|endometrium(7)|kidney(8)|large_intestine(9)|lung(29)|ovary(3)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(2)	71	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		AGACAGTTCTCAGCACCCAAT	0.473000													21	36					0	0	1	0	0
EIF5B	9669	broad.mit.edu	37	2	99998633	99998633	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:99998633G>C	ENST00000289371.6	+	13	2275	c.2073G>C	c.(2071-2073)gaG>gaC	p.E691D		NM_015904.3	NP_056988.3	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B						regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						TTGATAGAGAGAATGTACGGA	0.353000													8	53					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55826641	55826641	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:55826641G>C	ENST00000373965.2	-	19	2511	c.2117C>G	c.(2116-2118)tCa>tGa	p.S706*	PCDH15_ENST00000395432.2_Nonsense_Mutation_p.S662*|PCDH15_ENST00000320301.6_Nonsense_Mutation_p.S699*|PCDH15_ENST00000395430.1_Nonsense_Mutation_p.S699*|PCDH15_ENST00000409834.1_Nonsense_Mutation_p.S310*|PCDH15_ENST00000395433.1_Nonsense_Mutation_p.S677*|PCDH15_ENST00000361849.3_Nonsense_Mutation_p.S699*|PCDH15_ENST00000414778.1_Nonsense_Mutation_p.S704*|PCDH15_ENST00000395445.1_Nonsense_Mutation_p.S706*|PCDH15_ENST00000373955.1_Nonsense_Mutation_p.S699*|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000373957.3_Nonsense_Mutation_p.S677*|PCDH15_ENST00000437009.1_Nonsense_Mutation_p.S628*|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000395438.1_Nonsense_Mutation_p.S699*	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	699	Cadherin 6.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				TGTGGCAGTTGAGGTCTTAAA	0.368000										HNSCC(58;0.16)			6	89					0	0	1	0	0
INO80D	54891	broad.mit.edu	37	2	206869295	206869295	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:206869295C>T	ENST00000403263.1	-	11	3285	c.2881G>A	c.(2881-2883)Gaa>Aaa	p.E961K		NM_017759.4	NP_060229.3	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	0					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|cervix(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(9)|ovary(2)|prostate(1)|urinary_tract(2)	26						GCCATTAGTTCAGCAGAAGGC	0.597000													9	11					0	0	1	0	0
ARID1A	8289	broad.mit.edu	37	1	27057835	27057835	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:27057835C>T	ENST00000324856.7	+	3	1914	c.1543C>T	c.(1543-1545)Cag>Tag	p.Q515*	ARID1A_ENST00000457599.2_Nonsense_Mutation_p.Q515*|ARID1A_ENST00000374152.2_Nonsense_Mutation_p.Q132*	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	515					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CCAGTCCTCTCAGCCTCCATA	0.632000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								240	408					0	0	1	0	0
TARS	6897	broad.mit.edu	37	5	33459811	33459811	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:33459811G>A	ENST00000265112.3	+	11	1406	c.1095G>A	c.(1093-1095)agG>agA	p.R365R	TARS_ENST00000414361.2_Silent_p.R244R|TARS_ENST00000455217.2_Silent_p.R398R|TARS_ENST00000502553.1_Silent_p.R365R|TARS_ENST00000541634.1_Silent_p.R261R	NM_152295.4	NP_689508.3	P26639	SYTC_HUMAN	threonyl-tRNA synthetase	365					threonyl-tRNA aminoacylation	cytosol	ATP binding|protein homodimerization activity|threonine-tRNA ligase activity			NS(1)|biliary_tract(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(7)|lung(11)|ovary(2)|prostate(1)	29					L-Threonine(DB00156)	GCGAATATAGGAAAAGAGGAT	0.423000													69	57					0	0	1	0	0
POLR1D	51082	broad.mit.edu	37	13	28197305	28197305	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:28197305G>A	ENST00000302979.3	+	3	1342	c.320G>A	c.(319-321)tGc>tAc	p.C107Y	POLR1D_ENST00000399697.3_Intron|POLR1D_ENST00000399696.1_Missense_Mutation_p.C107Y|POLR1D_ENST00000465887.1_Intron	NM_015972.3	NP_057056.1	Q9Y2S0	RPAC2_HUMAN	polymerase (RNA) I polypeptide D, 16kDa	107					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein dimerization activity			endometrium(1)|large_intestine(1)|lung(4)|stomach(2)	8		Lung SC(185;0.0161)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	all cancers(112;0.0758)|OV - Ovarian serous cystadenocarcinoma(117;0.1)|Epithelial(112;0.213)		ATGAATGTCTGCCAACATGTG	0.423000													37	95					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32832645	32832645	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:32832645C>T	ENST00000421745.2	+	72	14328	c.14194C>T	c.(14194-14196)Cga>Tga	p.R4732*		NM_016252.3	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	4732					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					TGGAAACATTCGACAAGCAAC	0.378000													31	52					0	0	1	0	0
CDC6	990	broad.mit.edu	37	17	38445697	38445697	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:38445697C>T	ENST00000209728.4	+	2	496	c.25C>T	c.(25-27)Cag>Tag	p.Q9*		NM_001254.3	NP_001245.1	Q99741	CDC6_HUMAN	cell division cycle 6	9					cell division|DNA replication|DNA replication checkpoint|M/G1 transition of mitotic cell cycle|mitosis|negative regulation of cell proliferation|negative regulation of DNA replication|positive regulation of cell cycle cytokinesis|positive regulation of chromosome segregation|regulation of cyclin-dependent protein kinase activity|regulation of mitotic anaphase|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|traversing start control point of mitotic cell cycle	cytosol|nucleoplasm|spindle midzone|spindle pole	ATP binding|kinase binding|nucleoside-triphosphatase activity			breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|prostate(1)|stomach(2)|urinary_tract(1)	21						ATCCCAGGCACAGGCTACAAT	0.408000													29	46					0	0	1	0	0
GPAM	57678	broad.mit.edu	37	10	113928680	113928680	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:113928680G>A	ENST00000348367.4	-	10	1022	c.825C>T	c.(823-825)ttC>ttT	p.F275F	GPAM_ENST00000369425.1_Silent_p.F275F|GPAM_ENST00000423155.1_Silent_p.F275F			Q9HCL2	GPAT1_HUMAN	glycerol-3-phosphate acyltransferase, mitochondrial	275					phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity	p.F275F(1)		breast(2)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31				Epithelial(162;0.0306)|all cancers(201;0.123)		TTCGTCGTATGAAGAAGCCCC	0.373000													27	34					0	0	1	0	0
P4HB	5034	broad.mit.edu	37	17	79813139	79813139	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:79813139G>A	ENST00000331483.4	-	4	725	c.503C>T	c.(502-504)tCt>tTt	p.S168F	P4HB_ENST00000576390.1_Intron|P4HB_ENST00000472244.1_5'UTR|P4HB_ENST00000439918.2_Missense_Mutation_p.S124F	NM_000918.3	NP_000909.2	P07237	PDIA1_HUMAN	prolyl 4-hydroxylase, beta polypeptide	168					cell redox homeostasis|glycerol ether metabolic process|lipid metabolic process|lipoprotein metabolic process|peptidyl-proline hydroxylation to 4-hydroxy-L-proline	cell surface|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|extracellular region|melanosome|plasma membrane	electron carrier activity|procollagen-proline 4-dioxygenase activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			NS(1)|breast(1)|large_intestine(2)|lung(17)|urinary_tract(1)	22	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0509)			CTGCTTGGCAGAGTCCGACTC	0.552000													35	117					0	0	1	0	0
NCOR1	9611	broad.mit.edu	37	17	15995169	15995169	+	Nonstop_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:15995169C>G	ENST00000395848.1	-	19	2814	c.2745G>C	c.(2743-2745)taG>taC	p.*915Y	NCOR1_ENST00000395851.1_Intron|NCOR1_ENST00000268712.3_Intron	NM_001190438.1	NP_001177367.1	O75376	NCOR1_HUMAN	nuclear receptor corepressor 1	0					cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(26)|ovary(1)|prostate(7)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(10)	107				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		ATAGCTCTATCTACCTACCTT	0.428000													22	58					0	0	1	0	0
PPM1L	151742	broad.mit.edu	37	3	160474178	160474178	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:160474178C>T	ENST00000498165.1	+	1	183	c.82C>T	c.(82-84)Ctg>Ttg	p.L28L	PPM1L_ENST00000497343.1_Silent_p.L28L	NM_139245.2	NP_640338.2	Q5SGD2	PPM1L_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1L	28					protein dephosphorylation|sphingolipid metabolic process	endoplasmic reticulum membrane|integral to membrane|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			breast(1)|endometrium(1)|large_intestine(4)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	13			Lung(72;0.00149)|LUSC - Lung squamous cell carcinoma(72;0.00216)			GACGCTTTTCCTGCTGTGCAT	0.522000													15	89					0	0	1	0	0
AKAP10	11216	broad.mit.edu	37	17	19861683	19861683	+	Missense_Mutation	SNP	A	A	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:19861683A>T	ENST00000225737.6	-	4	678	c.521T>A	c.(520-522)cTa>cAa	p.L174Q	AKAP10_ENST00000572155.1_5'UTR|AKAP10_ENST00000395536.3_Missense_Mutation_p.L174Q	NM_007202.3	NP_009133.2	O43572	AKA10_HUMAN	A kinase (PRKA) anchor protein 10	174	RGS 1.				blood coagulation|protein localization	cytosol|mitochondrion|plasma membrane	signal transducer activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(3)|ovary(1)|prostate(1)|skin(3)|stomach(1)|urinary_tract(2)	21	all_cancers(12;2.08e-05)|all_epithelial(12;0.00158)|Breast(13;0.165)					CACTGTGTTTAGACTGTGTGC	0.413000													26	57					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75799843	75799843	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:75799843C>T	ENST00000322507.8	-	63	9233	c.8924G>A	c.(8923-8925)gGa>gAa	p.G2975E	COL12A1_ENST00000416123.2_Missense_Mutation_p.G2899E|COL12A1_ENST00000345356.6_Missense_Mutation_p.G1811E|COL12A1_ENST00000511023.1_5'UTR|COL12A1_ENST00000483888.2_Missense_Mutation_p.G2971E	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	2975	Triple-helical region (COL1) with 2 imperfections.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						CCCAGGGGGTCCCTGCATCCC	0.617000													65	115					0	0	1	0	0
EML3	256364	broad.mit.edu	37	11	62376050	62376050	+	Silent	SNP	G	G	A	rs138198368		TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:62376050G>A	ENST00000394773.2	-	9	1381	c.1074C>T	c.(1072-1074)ttC>ttT	p.F358F	EML3_ENST00000494176.2_Silent_p.F330F|EML3_ENST00000278845.4_Silent_p.F359F|EML3_ENST00000531557.1_Silent_p.F141F|EML3_ENST00000529309.1_Silent_p.F358F	NM_153265.2	NP_694997.2	Q32P44	EMAL3_HUMAN	echinoderm microtubule associated protein like 3	358						cytoplasm|microtubule	protein binding			biliary_tract(1)|breast(3)|endometrium(4)|kidney(2)|large_intestine(1)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26						CACCCCGCTCGAAGGCCCCCA	0.597000													51	348					0	0	1	0	0
ATP6V1E2	90423	broad.mit.edu	37	2	46739578	46739578	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:46739578G>C	ENST00000306448.4	-	2	1386	c.273C>G	c.(271-273)atC>atG	p.I91M	ATP6V1E2_ENST00000522587.1_Missense_Mutation_p.I91M	NM_080653.3	NP_542384.1	Q96A05	VATE2_HUMAN	ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2	91					cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|proton-transporting two-sector ATPase complex, catalytic domain	proton-transporting ATPase activity, rotational mechanism			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|skin(1)	13		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.151)			GCAAATCTGAGATGAGGTCAT	0.527000													29	70					0	0	1	0	0
RABEPK	10244	broad.mit.edu	37	9	127990287	127990287	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:127990287G>A	ENST00000373538.3	+	6	935	c.625G>A	c.(625-627)Gga>Aga	p.G209R	RABEPK_ENST00000394124.4_3'UTR|RABEPK_ENST00000394125.4_Missense_Mutation_p.G209R|RABEPK_ENST00000259460.8_Missense_Mutation_p.G158R	NM_005833.3	NP_005824.2	Q7Z6M1	RABEK_HUMAN	Rab9 effector protein with kelch motifs	209					receptor-mediated endocytosis|vesicle docking involved in exocytosis	endosome membrane|plasma membrane				NS(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(3)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	15						CTTCATCCACGGAGGCTTGGC	0.488000													7	50					0	0	1	0	0
GGA1	26088	broad.mit.edu	37	22	38014472	38014472	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr22:38014472G>C	ENST00000343632.4	+	4	608	c.222G>C	c.(220-222)atG>atC	p.M74I	GGA1_ENST00000406772.1_Start_Codon_SNP_p.M1I|GGA1_ENST00000405147.3_Missense_Mutation_p.M74I|GGA1_ENST00000381756.5_Missense_Mutation_p.M91I|GGA1_ENST00000325180.8_Missense_Mutation_p.M74I|GGA1_ENST00000337437.4_Intron	NM_001172687.1|NM_013365.4	NP_001166158.1|NP_037497.1	Q9UJY5	GGA1_HUMAN	golgi-associated, gamma adaptin ear containing, ARF binding protein 1	74	VHS.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|endosome membrane|Golgi apparatus part	protein binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|urinary_tract(1)	10	Melanoma(58;0.0574)					AAACATGCATGAAGAGCTGCG	0.637000													18	70					0	0	1	0	0
FRG2B	441581	broad.mit.edu	37	10	135439041	135439041	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:135439041G>T	ENST00000443774.1	-	4	451	c.402C>A	c.(400-402)caC>caA	p.H134Q	FRG2B_ENST00000425520.1_Missense_Mutation_p.H133Q			Q96QU4	FRG2B_HUMAN	FSHD region gene 2 family, member B	133						nucleus				endometrium(2)|kidney(2)|lung(14)|ovary(1)|prostate(1)	20		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		TTTCACTGTTGTGCACAGGAG	0.532000													38	59					1.90571e-15	2.01764e-15	1	1	0
SLC45A1	50651	broad.mit.edu	37	1	8390858	8390858	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:8390858G>A	ENST00000471889.1	+	5	1690	c.1305G>A	c.(1303-1305)ctG>ctA	p.L435L	SLC45A1_ENST00000481265.1_3'UTR|SLC45A1_ENST00000377479.2_Silent_p.L469L|SLC45A1_ENST00000289877.8_Silent_p.L435L			Q9Y2W3	S45A1_HUMAN	solute carrier family 45, member 1	435					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(2)	33	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		GGGACATTCTGAGGGTGGGCT	0.662000													28	83					0	0	1	0	0
GUCY1B3	2983	broad.mit.edu	37	4	156723650	156723650	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:156723650G>A	ENST00000264424.8	+	10	1414	c.1332G>A	c.(1330-1332)atG>atA	p.M444I	GUCY1B3_ENST00000503520.1_Missense_Mutation_p.M411I|GUCY1B3_ENST00000507146.1_Missense_Mutation_p.M419I|GUCY1B3_ENST00000502959.1_Missense_Mutation_p.M466I|GUCY1B3_ENST00000505154.1_Missense_Mutation_p.M376I|GUCY1B3_ENST00000505764.1_Missense_Mutation_p.M424I|GUCY1B3_ENST00000513437.1_Missense_Mutation_p.M376I	NM_000857.2	NP_000848.1	Q02153	GCYB1_HUMAN	guanylate cyclase 1, soluble, beta 3	444	Guanylate cyclase.				blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble|intracellular membrane-bounded organelle	GTP binding|guanylate cyclase activity|receptor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.148)		AAGGAGCCATGAAGATCGTCA	0.453000													3	25					0	0	1	0	0
FRS2	10818	broad.mit.edu	37	12	69968139	69968139	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:69968139G>A	ENST00000299293.2	+	10	1441	c.931G>A	c.(931-933)Ggg>Agg	p.G311R	FRS2_ENST00000550389.1_Missense_Mutation_p.G311R|FRS2_ENST00000549921.1_Missense_Mutation_p.G311R|FRS2_ENST00000397997.2_Missense_Mutation_p.G311R	NM_001278351.1|NM_006654.3	NP_001265280.1|NP_006645.3	Q8WU20	FRS2_HUMAN	fibroblast growth factor receptor substrate 2	311					activation of MAPKK activity|activation of phospholipase C activity|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|transmembrane receptor protein tyrosine phosphatase signaling pathway	endomembrane system|endosome|integral to plasma membrane|membrane fraction	fibroblast growth factor receptor binding|insulin receptor binding|phosphatase activator activity|transmembrane receptor protein tyrosine kinase adaptor activity			autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22	Breast(13;2.15e-06)|Esophageal squamous(21;0.187)		Epithelial(6;2.94e-18)|Lung(24;9.68e-05)|OV - Ovarian serous cystadenocarcinoma(12;0.000984)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			AAATATAAATGGGCTATCTAT	0.458000													28	48					0	0	1	0	0
ALOXE3	59344	broad.mit.edu	37	17	8018935	8018935	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:8018935C>G	ENST00000380149.1	-	3	922	c.892G>C	c.(892-894)Gaa>Caa	p.E298Q	ALOXE3_ENST00000318227.3_Missense_Mutation_p.E274Q|ALOXE3_ENST00000448843.2_Missense_Mutation_p.E142Q			Q9BYJ1	LOXE3_HUMAN	arachidonate lipoxygenase 3	142	Lipoxygenase.				leukotriene biosynthetic process		iron ion binding|lipoxygenase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(4)	31						CGGTAGCATTCTTGTCGGGCC	0.478000													31	58					0	0	1	0	0
OSMR	9180	broad.mit.edu	37	5	38869153	38869153	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:38869153C>G	ENST00000274276.3	+	2	409	c.7C>G	c.(7-9)Cta>Gta	p.L3V	OSMR_ENST00000502536.1_Missense_Mutation_p.L3V	NM_003999.2	NP_003990.1	Q99650	OSMR_HUMAN	oncostatin M receptor	3					cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	46	all_lung(31;0.000365)					ACTGATGGCTCTATTTGCAGT	0.338000													67	57					0	0	1	0	0
CSNK1A1P1	161635	broad.mit.edu	37	15	37109476	37109476	+	RNA	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:37109476G>C	ENST00000430593.3	-	0	746					NR_027320.1																						TAGTCATATTGATGGATCAGG	0.473000													26	47					0	0	1	0	0
GALNT13	114805	broad.mit.edu	37	2	155099224	155099224	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:155099224G>C	ENST00000392825.3	+	6	1059	c.492G>C	c.(490-492)ttG>ttC	p.L164F	GALNT13_ENST00000409237.1_Missense_Mutation_p.L164F	NM_052917.2	NP_443149.2	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)	164	Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|lung(37)|ovary(3)|pancreas(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	65						TTCTCAAGTTGACATTAGAGA	0.338000													11	25					0	0	1	0	0
HOXB9	3219	broad.mit.edu	37	17	46703547	46703547	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:46703547G>A	ENST00000311177.5	-	1	292	c.85C>T	c.(85-87)Cct>Tct	p.P29S	HOXB7_ENST00000567101.2_Intron|HOXB9_ENST00000550387.1_Missense_Mutation_p.P29S	NM_024017.4	NP_076922.1	P17482	HXB9_HUMAN	homeobox B9	29					canonical Wnt receptor signaling pathway|cell chemotaxis	mitochondrion|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(1)|large_intestine(1)|liver(1)|lung(6)|prostate(1)	12						TGGCCAGAAGGAAACTTGGCT	0.602000													6	25					0	0	1	0	0
MYO1B	4430	broad.mit.edu	37	2	192256914	192256914	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:192256914G>C	ENST00000392318.3	+	19	2310	c.2063G>C	c.(2062-2064)cGa>cCa	p.R688P	MYO1B_ENST00000339514.4_Missense_Mutation_p.R688P|MYO1B_ENST00000304164.4_Missense_Mutation_p.R688P|MYO1B_ENST00000392316.1_Missense_Mutation_p.R688P|MYO1B_ENST00000439065.2_5'UTR	NM_001130158.1	NP_001123630.1	O43795	MYO1B_HUMAN	myosin IB	688	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|central_nervous_system(6)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(19)|ovary(1)	55			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			ATATTCATCCGAAACCCAAGA	0.303000													12	49					0	0	1	0	0
HAPLN2	60484	broad.mit.edu	37	1	156594201	156594201	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:156594201G>A	ENST00000255039.1	+	5	905	c.498G>A	c.(496-498)gcG>gcA	p.A166A	HAPLN2_ENST00000494218.1_3'UTR	NM_021817.2	NP_068589.1	Q9GZV7	HPLN2_HUMAN	hyaluronan and proteoglycan link protein 2	166	Link 1.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			NS(1)|endometrium(2)|large_intestine(1)|lung(1)|skin(1)|urinary_tract(1)	7	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					ACTACGAGGCGAAGCAGGCGT	0.672000													13	27					0	0	1	0	0
NALCN	259232	broad.mit.edu	37	13	102029158	102029158	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:102029158C>T	ENST00000251127.6	-	6	618	c.537G>A	c.(535-537)tgG>tgA	p.W179*	NALCN_ENST00000376196.3_Nonsense_Mutation_p.W179*|NALCN_ENST00000376200.5_Nonsense_Mutation_p.W179*|NALCN_ENST00000470333.1_5'UTR	NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	179						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TGGAAACACTCCATATTTGTT	0.308000													19	105					0	0	1	0	0
CDKL2	8999	broad.mit.edu	37	4	76529105	76529105	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:76529105T>C	ENST00000429927.2	-	6	1394	c.691A>G	c.(691-693)Aaa>Gaa	p.K231E	CDKL2_ENST00000307465.4_Missense_Mutation_p.K231E	NM_003948.3	NP_003939.1	Q92772	CDKL2_HUMAN	cyclin-dependent kinase-like 2 (CDC2-related kinase)	231	Protein kinase.				sex differentiation|signal transduction	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			breast(3)|endometrium(1)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(2)|stomach(2)	22			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			ACAGGATTTTTATTAAAAAGC	0.388000													10	49					0	0	1	0	0
STK38L	23012	broad.mit.edu	37	12	27470859	27470859	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:27470859A>G	ENST00000389032.3	+	11	1155	c.986A>G	c.(985-987)cAa>cGa	p.Q329R	STK38L_ENST00000539577.1_Missense_Mutation_p.Q236R	NM_015000.3	NP_055815.1	Q9Y2H1	ST38L_HUMAN	serine/threonine kinase 38 like	329	Protein kinase.				intracellular protein kinase cascade|regulation of cellular component organization	actin cytoskeleton|cytoplasm	actin binding|ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)|skin(1)	12	Colorectal(261;0.0847)					GAAACACCTCAAGAAACGTAC	0.383000													11	21					0	0	1	0	0
PLCD3	113026	broad.mit.edu	37	17	43195690	43195690	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:43195690G>A	ENST00000322765.5	-	6	1196	c.1083C>T	c.(1081-1083)atC>atT	p.I361I	PLCD3_ENST00000540511.1_5'UTR	NM_133373.3	NP_588614.1	Q8N3E9	PLCD3_HUMAN	phospholipase C, delta 3	361	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process	cleavage furrow|cytoplasm|membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(2)|endometrium(2)|large_intestine(3)|lung(5)|prostate(1)|stomach(2)|urinary_tract(2)	17					Phosphatidylserine(DB00144)	TGGGCCCCCCGATCTGGGAGT	0.592000													28	85					0	0	1	0	0
FOXN1	8456	broad.mit.edu	37	17	26862193	26862193	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:26862193C>T	ENST00000226247.2	+	7	1633	c.1604C>T	c.(1603-1605)tCa>tTa	p.S535L	FOXN1_ENST00000579795.1_Missense_Mutation_p.S535L	NM_003593.2	NP_003584.2	O15353	FOXN1_HUMAN	forkhead box N1	535					defense response|embryo development|epithelial cell proliferation|keratinocyte differentiation|organ morphogenesis|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|thymus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(1)|large_intestine(3)|lung(8)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Lung NSC(42;0.00431)					ATCAATCCCTCACTCACTGAC	0.597000													16	37					0	0	1	0	0
PTPN3	5774	broad.mit.edu	37	9	112225592	112225592	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:112225592C>T	ENST00000374541.2	-	2	227	c.123G>A	c.(121-123)caG>caA	p.Q41Q	PTPN3_ENST00000262539.3_5'UTR	NM_001145368.1|NM_002829.3	NP_001138840.1|NP_002820.3	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type 3	41	FERM.				negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	41						CTTTAAAGGTCTGTACCACGC	0.358000													25	43					0	0	1	0	0
STAC	6769	broad.mit.edu	37	3	36422160	36422160	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:36422160G>A	ENST00000273183.3	+	1	325	c.25G>A	c.(25-27)Gag>Aag	p.E9K	STAC_ENST00000457375.2_Missense_Mutation_p.E9K	NM_003149.1	NP_003140.1	Q99469	STAC_HUMAN	SH3 and cysteine rich domain	9					intracellular signal transduction	cytoplasm|soluble fraction	metal ion binding			endometrium(5)|large_intestine(9)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(5)	32						CAGCCCCCGCGAGGACGGCGT	0.721000													3	22					0	0	1	0	0
CD1A	909	broad.mit.edu	37	1	158226040	158226040	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:158226040T>C	ENST00000289429.5	+	3	1105	c.572T>C	c.(571-573)cTt>cCt	p.L191P		NM_001763.2	NP_001754.2	P06126	CD1A_HUMAN	CD1a molecule	191	Ig-like.				antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(14)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	32	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	TTGGGTCTTCTTGATGCAGGA	0.468000													37	116					0	0	1	0	0
PLCB2	5330	broad.mit.edu	37	15	40594208	40594208	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:40594208G>A	ENST00000260402.3	-	7	781	c.532C>T	c.(532-534)Cgc>Tgc	p.R178C	PLCB2_ENST00000543785.2_Missense_Mutation_p.R178C|PLCB2_ENST00000456256.2_Missense_Mutation_p.R178C|PLCB2_ENST00000557821.1_Missense_Mutation_p.R178C	NM_001284297.1|NM_004573.2	NP_001271226.1|NP_004564.2	Q00722	PLCB2_HUMAN	phospholipase C, beta 2	178					activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(4)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(3)	39		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)		ACCCGCTTGCGGTCAGCAGGA	0.582000													3	61					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76503684	76503684	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:76503684G>A	ENST00000389840.5	-	28	4552	c.4428C>T	c.(4426-4428)tcC>tcT	p.S1476S	DNAH17_ENST00000585328.1_Silent_p.S1477S					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			AGTCCGCCGTGGACAGCTTCT	0.592000													10	55					0	0	1	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54920519	54920519	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:54920519C>T	ENST00000293373.6	+	21	2443	c.2364C>T	c.(2362-2364)ctC>ctT	p.L788L	NCKAP1L_ENST00000545638.2_Silent_p.L738L	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	788					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						TCACCACACTCTACACAAACT	0.512000													15	20					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4189070	4189070	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:4189070G>A	ENST00000404826.2	+	30	4739	c.4600G>A	c.(4600-4602)Gag>Aag	p.E1534K	SDK1_ENST00000389531.3_Missense_Mutation_p.E1534K	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	1534	Fibronectin type-III 9.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CATCAGCCATGAGGCGACAGC	0.667000													8	10					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123844550	123844550	+	Silent	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:123844550C>G	ENST00000369005.1	+	4	2875	c.2535C>G	c.(2533-2535)ctC>ctG	p.L845L	TACC2_ENST00000515603.1_Silent_p.L845L|TACC2_ENST00000513429.1_Intron|TACC2_ENST00000515273.1_Silent_p.L845L|TACC2_ENST00000453444.2_Silent_p.L845L|TACC2_ENST00000334433.3_Silent_p.L845L|TACC2_ENST00000358010.1_Intron	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	845						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				TTGACGTGCTCAAGGAGCAGG	0.527000													103	66					0	0	1	0	0
GPR158	57512	broad.mit.edu	37	10	25465209	25465209	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:25465209C>A	ENST00000376351.3	+	1	1219	c.860C>A	c.(859-861)tCt>tAt	p.S287Y		NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	287						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						ACTCTTTCCTCTGCCATCTAC	0.612000													28	22					1.56738e-10	1.63779e-10	1	1	0
PKD1L1	168507	broad.mit.edu	37	7	47886526	47886526	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:47886526C>T	ENST00000289672.2	-	32	5154	c.5104G>A	c.(5104-5106)Gaa>Aaa	p.E1702K		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	1702	GPS.				cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						GAGAAACGTTCAGATTTCCAC	0.408000													31	79					0	0	1	0	0
LAMC1	3915	broad.mit.edu	37	1	183086502	183086502	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:183086502C>G	ENST00000258341.4	+	9	1869	c.1612C>G	c.(1612-1614)Ctc>Gtc	p.L538V		NM_002293.3	NP_002284.3	P11047	LAMC1_HUMAN	laminin, gamma 1 (formerly LAMB2)	538	Laminin IV type A.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(27)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	76					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGAAGCATCTCTCGAGTGGTC	0.488000													24	15					0	0	1	0	0
PTH2	113091	broad.mit.edu	37	19	49926533	49926533	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:49926533G>C	ENST00000270631.1	-	1	165	c.64C>G	c.(64-66)Ctg>Gtg	p.L22V		NM_178449.3	NP_848544.1	Q96A98	TIP39_HUMAN	parathyroid hormone 2	22					neuropeptide signaling pathway	extracellular region		p.L22V(2)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(262;0.0015)|GBM - Glioblastoma multiforme(486;0.044)|Lung(386;0.0785)|LUSC - Lung squamous cell carcinoma(496;0.0836)		GGCACCACcagcagcagcagc	0.692000													3	38					0	0	1	0	0
SNTB2	6645	broad.mit.edu	37	16	69279609	69279609	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:69279609G>A	ENST00000336278.4	+	2	723	c.685G>A	c.(685-687)Gag>Aag	p.E229K	SNTB2_ENST00000528525.1_3'UTR	NM_006750.3	NP_006741.1	Q13425	SNTB2_HUMAN	syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)	229	PH 1.					cell junction|dystrophin-associated glycoprotein complex|membrane fraction|microtubule|transport vesicle membrane	actin binding|calmodulin binding|protein binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	13		Ovarian(137;0.101)		OV - Ovarian serous cystadenocarcinoma(108;0.208)		TAGTGGCAGTGAGGACTCTGG	0.493000													189	214					0	0	1	0	0
PRDX1	5052	broad.mit.edu	37	1	45977057	45977057	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:45977057C>T	ENST00000262746.1	-	6	883	c.544G>A	c.(544-546)Gat>Aat	p.D182N	PRDX1_ENST00000372079.1_Missense_Mutation_p.D80N|PRDX1_ENST00000319248.8_Missense_Mutation_p.D182N	NM_002574.3|NM_181696.2	NP_002565.1|NP_859047.1	Q06830	PRDX1_HUMAN	peroxiredoxin 1	182					cell proliferation|cell redox homeostasis|hydrogen peroxide catabolic process|skeletal system development	melanosome|mitochondrion|nucleus	protein binding|thioredoxin peroxidase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|skin(1)	12	Acute lymphoblastic leukemia(166;0.155)					TTGATGGTATCACTGCCAGGT	0.493000													157	279					0	0	1	0	0
AKAP11	11215	broad.mit.edu	37	13	42877371	42877371	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:42877371G>A	ENST00000025301.2	+	8	4664	c.4489G>A	c.(4489-4491)Gaa>Aaa	p.E1497K		NM_016248.3	NP_057332.1	Q9UKA4	AKA11_HUMAN	A kinase (PRKA) anchor protein 11	1497					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|skin(3)|stomach(2)	56		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		TGGATATGAAGAAGATAATGA	0.398000													42	40					0	0	1	0	0
DPP10	57628	broad.mit.edu	37	2	116066832	116066832	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:116066832C>T	ENST00000410059.1	+	2	558	c.78C>T	c.(76-78)agC>agT	p.S26S	DPP10_ENST00000310323.8_Silent_p.S19S|DPP10_ENST00000409163.1_5'UTR|DPP10_ENST00000393147.2_Silent_p.S30S	NM_001178037.1|NM_020868.3	NP_001171508.1|NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl-peptidase 10 (non-functional)	26	Mediates effects on KCND2.				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(24)|liver(2)|lung(48)|ovary(6)|prostate(1)|skin(5)|soft_tissue(1)	101						GAAGTAACAGCCCTCCACAGA	0.403000													19	24					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37028425	37028425	+	Missense_Mutation	SNP	A	A	G	rs145580328	byFrequency	TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chrX:37028425A>G	ENST00000358047.3	+	1	1994	c.1942A>G	c.(1942-1944)Aat>Gat	p.N648D		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	648								p.N648D(7)		breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						GGAGCCTCCCAATACTGGAGT	0.642000													6	127					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42047045	42047045	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:42047045G>T	ENST00000372584.1	-	3	4438	c.3424C>A	c.(3424-3426)Cca>Aca	p.P1142T	HIVEP3_ENST00000429157.2_Missense_Mutation_p.P1142T|HIVEP3_ENST00000372583.1_Missense_Mutation_p.P1142T|HIVEP3_ENST00000247584.5_Missense_Mutation_p.P1142T	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	1142					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				AGGGAGACTGGTGGGGGCAGG	0.602000													59	129					1.05635e-38	1.1505e-38	1	1	0
C6orf89	221477	broad.mit.edu	37	6	36887410	36887410	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:36887410C>T	ENST00000480824.2	+	8	1176	c.882C>T	c.(880-882)ctC>ctT	p.L294L	C6orf89_ENST00000373685.1_Silent_p.L294L|C6orf89_ENST00000359359.2_Silent_p.L188L|C6orf89_ENST00000355190.3_Silent_p.L301L|C6orf89_ENST00000510325.2_Silent_p.L188L			Q6UWU4	CF089_HUMAN	chromosome 6 open reading frame 89	294						integral to membrane				breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)|skin(2)	15						TGTTGCAGCTCATCCCTCCCT	0.532000													72	79					0	0	1	0	0
TNFSF15	9966	broad.mit.edu	37	9	117568272	117568272	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:117568272C>T	ENST00000374045.4	-	1	134	c.21G>A	c.(19-21)ctG>ctA	p.L7L		NM_001204344.1|NM_005118.3	NP_001191273.1|NP_005109.2	O95150	TNF15_HUMAN	tumor necrosis factor (ligand) superfamily, member 15	7					activation of caspase activity|activation of NF-kappaB-inducing kinase activity|cytokine metabolic process|immune response	extracellular space|integral to plasma membrane	cytokine activity|tumor necrosis factor receptor binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|skin(1)	11						CCCCAAAGCTCAGTCCCAGAT	0.622000													43	87					0	0	1	0	0
NUTM2G	441457	broad.mit.edu	37	9	99691320	99691320	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:99691320G>C	ENST00000354649.3	+	1	729	c.14G>C	c.(13-15)gGa>gCa	p.G5A	NUTM2G_ENST00000372322.3_Missense_Mutation_p.G5A|HIATL2_ENST00000506067.1_Intron	NM_001045477.2	NP_001038942.1			NUT family member 2G																		GCTTCAAATGGAGGTGAGCCT	0.537000													91	106					0	0	1	0	0
IPO7	10527	broad.mit.edu	37	11	9435902	9435902	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:9435902G>A	ENST00000379719.3	+	5	722	c.580G>A	c.(580-582)Gat>Aat	p.D194N		NM_006391.2	NP_006382.1	O95373	IPO7_HUMAN	importin 7	194					interspecies interaction between organisms|signal transduction	Golgi apparatus|nuclear pore|soluble fraction	protein transporter activity|Ran GTPase binding|small GTPase regulator activity			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				all cancers(16;8.29e-09)|Epithelial(150;4.76e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0217)		TGACCAGTCTGATCAGTCTGT	0.398000													66	68					0	0	1	0	0
BPTF	2186	broad.mit.edu	37	17	65890162	65890162	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:65890162C>G	ENST00000321892.4	+	9	2863	c.2802C>G	c.(2800-2802)atC>atG	p.I934M	BPTF_ENST00000306378.6_Missense_Mutation_p.I808M|BPTF_ENST00000335221.5_Missense_Mutation_p.I934M|BPTF_ENST00000424123.3_Missense_Mutation_p.I795M			Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	934					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(23)|ovary(3)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	78	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			CAAATTGGATCAAGGCAGTTC	0.393000													48	69					0	0	1	0	0
AKAP12	9590	broad.mit.edu	37	6	151674198	151674198	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:151674198G>A	ENST00000402676.2	+	4	4912	c.4672G>A	c.(4672-4674)Gtt>Att	p.V1558I	AKAP12_ENST00000253332.1_Missense_Mutation_p.V1558I|AKAP12_ENST00000354675.6_Missense_Mutation_p.V1460I|AKAP12_ENST00000359755.5_Missense_Mutation_p.V1453I	NM_005100.3	NP_005091.2	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12	1558					G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	68		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		CCAGACAGCCGTTGACCAGTT	0.448000													28	91					0	0	1	0	0
SLC24A4	123041	broad.mit.edu	37	14	92922835	92922835	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:92922835C>A	ENST00000532405.1	+	12	1364	c.1138C>A	c.(1138-1140)Cct>Act	p.P380T	SLC24A4_ENST00000531433.1_Missense_Mutation_p.P361T|SLC24A4_ENST00000393265.2_Missense_Mutation_p.P316T|SLC24A4_ENST00000351924.5_Missense_Mutation_p.P344T|SLC24A4_ENST00000556739.1_3'UTR|SLC24A4_ENST00000298877.1_Missense_Mutation_p.P363T			Q8NFF2	NCKX4_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 4	380						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(6)|lung(20)|ovary(2)|skin(1)	36		all_cancers(154;0.0347)|all_epithelial(191;0.163)		Colorectal(1;0.00242)|COAD - Colon adenocarcinoma(157;0.047)|Epithelial(152;0.0781)|READ - Rectum adenocarcinoma(1;0.176)|all cancers(159;0.182)		CGGGAATGTTCCTGTGGAAAA	0.597000											OREG0022876	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	38	51					6.33695e-27	6.83973e-27	1	1	0
ABHD17C	58489	broad.mit.edu	37	15	80988240	80988240	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:80988240C>T	ENST00000258884.4	+	1	597	c.470C>T	c.(469-471)tCc>tTc	p.S157F	ABHD17C_ENST00000560609.1_Intron|ABHD17C_ENST00000558464.1_Missense_Mutation_p.S157F	NM_021214.1	NP_067037.1			abhydrolase domain containing 17C																		GGCCTCGGCTCCCGCATCAAC	0.637000													4	16					0	0	1	0	0
CEACAM8	1088	broad.mit.edu	37	19	43093837	43093837	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:43093837C>T	ENST00000244336.5	-	3	576	c.475G>A	c.(475-477)Gac>Aac	p.D159N	LIPE-AS1_ENST00000594624.2_RNA|CEACAM8_ENST00000599005.1_Intron|LIPE-AS1_ENST00000594688.1_RNA	NM_001816.3	NP_001807.2	P31997	CEAM8_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 8	159	Ig-like C2-type 1.				immune response	anchored to membrane|extracellular space|integral to plasma membrane				endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	16		Prostate(69;0.00899)				GCATCCTTGTCCTCCACGGGG	0.552000													86	214					0	0	1	0	0
TNNC2	7125	broad.mit.edu	37	20	44453014	44453014	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:44453014C>T	ENST00000372557.1	-	5	393	c.186G>A	c.(184-186)ttG>ttA	p.L62L	TNNC2_ENST00000372555.3_Silent_p.L77L			P02585	TNNC2_HUMAN	troponin C type 2 (fast)	77	EF-hand 2.				muscle filament sliding|regulation of muscle contraction|skeletal muscle contraction	cytosol|troponin complex	calcium ion binding			endometrium(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	5		Myeloproliferative disorder(115;0.0122)				CCATCATGACCAAGAACTCCT	0.662000													31	168					0	0	1	0	0
PLCB3	5331	broad.mit.edu	37	11	64030227	64030227	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:64030227C>T	ENST00000540288.1	+	19	2405	c.2302C>T	c.(2302-2304)Cag>Tag	p.Q768*	PLCB3_ENST00000325234.5_Nonsense_Mutation_p.Q701*|PLCB3_ENST00000279230.6_Nonsense_Mutation_p.Q768*	NM_000932.2	NP_000923.1	Q01970	PLCB3_HUMAN	phospholipase C, beta 3 (phosphatidylinositol-specific)	768	C2.				intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|pancreas(1)|prostate(3)|urinary_tract(1)	33						CCGGACCTCTCAGGGGAACTC	0.637000													165	227					0	0	1	0	0
PPAT	5471	broad.mit.edu	37	4	57266984	57266984	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:57266984G>C	ENST00000264220.2	-	8	1117	c.980C>G	c.(979-981)tCt>tGt	p.S327C		NM_002703.4	NP_002694.3	Q06203	PUR1_HUMAN	phosphoribosyl pyrophosphate amidotransferase	327					glutamine metabolic process|nucleoside metabolic process|purine base biosynthetic process|purine ribonucleoside monophosphate biosynthetic process	cytosol	4 iron, 4 sulfur cluster binding|amidophosphoribosyltransferase activity|metal ion binding			cervix(1)|endometrium(2)|large_intestine(6)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)	20	Glioma(25;0.08)|all_neural(26;0.101)				L-Glutamine(DB00130)|Thioguanine(DB00352)	AGGCGTAGCAGATTCTGGAAC	0.458000													36	121					0	0	1	0	0
GARNL3	84253	broad.mit.edu	37	9	130119513	130119513	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:130119513G>T	ENST00000373387.4	+	21	2303	c.1951G>T	c.(1951-1953)Gac>Tac	p.D651Y	GARNL3_ENST00000314904.5_Missense_Mutation_p.D651Y|GARNL3_ENST00000496711.1_3'UTR|GARNL3_ENST00000435213.2_Missense_Mutation_p.D629Y	NM_032293.4	NP_115669.3	Q5VVW2	GARL3_HUMAN	GTPase activating Rap/RanGAP domain-like 3	651	CNH.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			NS(1)|central_nervous_system(1)|endometrium(6)|large_intestine(5)|lung(24)|ovary(1)|skin(1)|urinary_tract(2)	41						CTGTCTGTCTGACTCTCCCAT	0.522000													12	101					3.27435e-08	3.3871e-08	1	1	0
DDX26B	203522	broad.mit.edu	37	X	134709105	134709105	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chrX:134709105C>T	ENST00000370752.4	+	13	2061	c.1727C>T	c.(1726-1728)cCc>cTc	p.P576L	DDX26B_ENST00000481908.1_3'UTR	NM_182540.4	NP_872346.3	Q5JSJ4	DX26B_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B	576										large_intestine(1)|lung(8)	9	Acute lymphoblastic leukemia(192;6.56e-05)					CCAGACCAACCCAAAAGACTG	0.403000													59	29					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45353208	45353208	+	Silent	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:45353208C>G	ENST00000303230.4	-	5	1428	c.1371G>C	c.(1369-1371)ctG>ctC	p.L457L		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	457						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity	p.L457L(1)		NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						TTACCTCTCTCAGAGGATCAT	0.343000													7	71					0	0	1	0	0
NOTCH4	4855	broad.mit.edu	37	6	32166323	32166323	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:32166323C>T	ENST00000375023.3	-	26	4769	c.4631G>A	c.(4630-4632)gGc>gAc	p.G1544D		NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4	1544					cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						GGAGGGTGGGCCTGTTTCTTC	0.572000													15	43					0	0	1	0	0
ZNF160	90338	broad.mit.edu	37	19	53572357	53572357	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:53572357C>T	ENST00000601421.1	-	3	2198	c.1322G>A	c.(1321-1323)gGa>gAa	p.G441E	ZNF160_ENST00000599056.1_Missense_Mutation_p.G477E|ZNF160_ENST00000429604.1_Missense_Mutation_p.G477E|ZNF160_ENST00000418871.1_Missense_Mutation_p.G477E			Q9HCG1	ZN160_HUMAN	zinc finger protein 160	477					hemopoiesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(8)|lung(10)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	35				GBM - Glioblastoma multiforme(134;0.02)		AGGTTTTGTTCCAGTATGGAT	0.398000													36	84					0	0	1	0	0
PRR5-ARHGAP8	553158	broad.mit.edu	37	22	45198028	45198028	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr22:45198028C>T	ENST00000352766.7	+	9	913	c.913C>T	c.(913-915)Cac>Tac	p.H305Y	PRR5-ARHGAP8_ENST00000361473.5_Missense_Mutation_p.H182Y|ARHGAP8_ENST00000356099.6_Missense_Mutation_p.H51Y|ARHGAP8_ENST00000517296.3_Missense_Mutation_p.H305Y|ARHGAP8_ENST00000336963.4_Missense_Mutation_p.H51Y|ARHGAP8_ENST00000389774.2_Missense_Mutation_p.H51Y|ARHGAP8_ENST00000389773.5_Missense_Mutation_p.H173Y																breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(10)|prostate(1)|skin(8)	30						CGAGCTGGACCACCAGCGGCT	0.597000													11	72					0	0	1	0	0
ATF1	466	broad.mit.edu	37	12	51207891	51207891	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:51207891C>T	ENST00000262053.3	+	5	449	c.427C>T	c.(427-429)Cag>Tag	p.Q143*	ATF1_ENST00000539132.1_Nonsense_Mutation_p.Q8*	NM_005171.4	NP_005162.1	P18846	ATF1_HUMAN	activating transcription factor 1	143					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway				EWSR1/ATF1(347)|FUS/ATF1(4)	breast(1)|large_intestine(1)|ovary(2)	4						AGGCAGTACTCAGCAAGGTAC	0.468000			T	"""EWSR1, FUS"""	"""malignant melanoma of soft parts , angiomatoid fibrous histiocytoma """								14	63					0	0	1	0	0
RFWD3	55159	broad.mit.edu	37	16	74678291	74678291	+	Missense_Mutation	SNP	A	A	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:74678291A>C	ENST00000361070.4	-	6	1145	c.1048T>G	c.(1048-1050)Ttg>Gtg	p.L350V	RFWD3_ENST00000571750.1_Missense_Mutation_p.L350V	NM_018124.3	NP_060594.3	Q6PCD5	RFWD3_HUMAN	ring finger and WD repeat domain 3	350					DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|response to ionizing radiation	nucleus	MDM2 binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	26						CTAGTGTCCAAAGCTCTCAGG	0.453000													36	227					0	0	1	0	0
PADI1	29943	broad.mit.edu	37	1	17552410	17552410	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:17552410G>A	ENST00000375471.4	+	5	605	c.513G>A	c.(511-513)ctG>ctA	p.L171L		NM_013358.2	NP_037490.2	Q9ULC6	PADI1_HUMAN	peptidyl arginine deiminase, type I	171					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	28		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00054)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00522)|BRCA - Breast invasive adenocarcinoma(304;1.3e-05)|COAD - Colon adenocarcinoma(227;1.31e-05)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(196;0.0069)|READ - Rectum adenocarcinoma(331;0.0681)|Lung(427;0.197)	L-Citrulline(DB00155)	ACAGCTGGCTGATGTCGCTGG	0.612000													111	223					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133899037	133899037	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:133899037G>C	ENST00000220616.4	+	9	1460	c.1420G>C	c.(1420-1422)Ggg>Cgg	p.G474R	TG_ENST00000377869.1_Missense_Mutation_p.G474R	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	474					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CCTTTTTGGAGGGAAATTTTT	0.473000													32	41					0	0	1	0	0
SMAP2	64744	broad.mit.edu	37	1	40875495	40875495	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:40875495C>G	ENST00000539317.1	+	4	343	c.150C>G	c.(148-150)atC>atG	p.I50M		NM_001198980.1	NP_001185909.1	Q8WU79	SMAP2_HUMAN	small ArfGAP2	130	Arf-GAP.				regulation of ARF GTPase activity	cytoplasm|nucleus	ARF GTPase activator activity|zinc ion binding			central_nervous_system(3)|kidney(1)|large_intestine(7)|lung(9)|ovary(1)|pancreas(2)|upper_aerodigestive_tract(1)	24	Lung NSC(20;1.56e-05)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.04e-17)			GTCTGGACATCAATGCCTTTA	0.373000													16	23					0	0	1	0	0
ZFP36L2	678	broad.mit.edu	37	2	43452478	43452478	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:43452478C>G	ENST00000282388.3	-	2	758	c.465G>C	c.(463-465)aaG>aaC	p.K155N	THADA_ENST00000330266.7_Intron	NM_006887.4	NP_008818.3	P47974	TISD_HUMAN	ZFP36 ring finger protein-like 2	155					cell proliferation	nucleus	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.K155N(1)		breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	15		Acute lymphoblastic leukemia(82;0.00323)|all_hematologic(82;0.00824)				ACAGCTCGGTCTTGTAGCGCG	0.657000													11	47					0	0	1	0	0
SEMA3A	10371	broad.mit.edu	37	7	83764184	83764184	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:83764184G>A	ENST00000265362.4	-	2	510	c.196C>T	c.(196-198)Cgg>Tgg	p.R66W	SEMA3A_ENST00000436949.1_Missense_Mutation_p.R66W	NM_006080.2	NP_006071.1	Q14563	SEM3A_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A		Sema.				axon guidance	extracellular region|membrane	receptor activity			breast(3)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53						AGCCTACTCCGTTCCTCATCC	0.388000													3	72					0	0	1	0	0
AKAP11	11215	broad.mit.edu	37	13	42876628	42876628	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:42876628C>T	ENST00000025301.2	+	8	3921	c.3746C>T	c.(3745-3747)tCa>tTa	p.S1249L		NM_016248.3	NP_057332.1	Q9UKA4	AKA11_HUMAN	A kinase (PRKA) anchor protein 11	1249					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|skin(3)|stomach(2)	56		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		TTAAACCCCTCAGACGAAAAT	0.363000													28	32					0	0	1	0	0
ITGB4	3691	broad.mit.edu	37	17	73727372	73727372	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:73727372G>A	ENST00000200181.3	+	10	1325	c.1138G>A	c.(1138-1140)Ggc>Agc	p.G380S	ITGB4_ENST00000584558.1_3'UTR|ITGB4_ENST00000450894.3_Missense_Mutation_p.G380S|ITGB4_ENST00000449880.2_Missense_Mutation_p.G380S|ITGB4_ENST00000579662.1_Missense_Mutation_p.G380S|ITGB4_ENST00000339591.3_Missense_Mutation_p.G380S	NM_000213.3	NP_000204.3	P16144	ITB4_HUMAN	integrin, beta 4	380					cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(1)|lung(25)|skin(1)|urinary_tract(1)	43	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			CAGCCCCCGAGGCCTTCGGAC	0.637000													15	97					0	0	1	0	0
GLB1L2	89944	broad.mit.edu	37	11	134238561	134238561	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:134238561A>G	ENST00000535456.2	+	10	1101	c.913A>G	c.(913-915)Att>Gtt	p.I305V	GLB1L2_ENST00000529077.1_3'UTR|GLB1L2_ENST00000339772.7_Missense_Mutation_p.I305V|GLB1L2_ENST00000389881.3_Missense_Mutation_p.I305V	NM_138342.3	NP_612351.2	Q8IW92	GLBL2_HUMAN	galactosidase, beta 1-like 2	305					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(20)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41	all_hematologic(175;0.127)	all_cancers(12;2.85e-18)|all_epithelial(12;1.21e-12)|all_lung(97;0.000276)|Lung NSC(97;0.000518)|Breast(109;0.00122)|Medulloblastoma(222;0.0399)|all_neural(223;0.0412)|Esophageal squamous(93;0.0844)		Epithelial(10;1.37e-11)|all cancers(11;2.2e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000885)|Lung(977;0.223)		CGTGTCTGCCATTGTGGACGC	0.532000													12	72					0	0	1	0	0
ZNF286B	729288	broad.mit.edu	37	17	18565289	18565289	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:18565289G>A	ENST00000545289.1	-	5	1780	c.1530C>T	c.(1528-1530)ctC>ctT	p.L510L	ZNF286B_ENST00000285274.5_3'UTR	NM_001145045.1	NP_001138517.1	P0CG31	Z286B_HUMAN	zinc finger protein 286B	510					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|lung(1)	2						GATGTCTGATGAGAGATGAAC	0.358000													16	46					0	0	1	0	0
TRIM16	10626	broad.mit.edu	37	17	15532492	15532492	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:15532492C>T	ENST00000455584.2	-	6	1175	c.1132G>A	c.(1132-1134)Gac>Aac	p.D378N	TRIM16_ENST00000579219.1_Silent_p.L74L|TRIM16_ENST00000578237.1_Missense_Mutation_p.D378N|TRIM16_ENST00000416464.2_Missense_Mutation_p.D248N|TRIM16_ENST00000336708.7_Missense_Mutation_p.D378N|TRIM16_ENST00000577886.1_Missense_Mutation_p.D162N																							GTGTCCGGGTCAAACGTGATG	0.567000													43	75					0	0	1	0	0
HCST	10870	broad.mit.edu	37	19	36393522	36393522	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:36393522C>T	ENST00000246551.4	+	1	141	c.27C>T	c.(25-27)ttC>ttT	p.F9F	HCST_ENST00000437550.2_Silent_p.F9F			Q9UBK5	HCST_HUMAN	hematopoietic cell signal transducer	9					regulation of immune response	integral to membrane|plasma membrane				lung(4)	4	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			ACATCCTCTTCCTGCTTTTGC	0.582000													174	213					0	0	1	0	0
IPO11	51194	broad.mit.edu	37	5	61733234	61733234	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:61733234C>T	ENST00000325324.6	+	2	297	c.128C>T	c.(127-129)tCa>tTa	p.S43L	IPO11_ENST00000409296.3_Missense_Mutation_p.S83L|KIF2A_ENST00000509663.2_Intron	NM_016338.4	NP_057422.3	Q9UI26	IPO11_HUMAN	importin 11	43	Importin N-terminal.					cytoplasm|nucleus	protein binding			endometrium(2)|kidney(3)|large_intestine(5)|lung(14)|skin(4)|stomach(2)	30		Lung NSC(810;8.99e-06)|Prostate(74;0.0235)|Ovarian(174;0.0511)|Breast(144;0.077)		Lung(70;0.0613)		GGTTTCTATTCAGTGTTGCTG	0.378000													19	25					0	0	1	0	0
REG3A	5068	broad.mit.edu	37	2	79385578	79385578	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:79385578C>T	ENST00000393878.1	-	3	461	c.207G>A	c.(205-207)caG>caA	p.Q69Q	REG3A_ENST00000305165.2_Silent_p.Q69Q|AC011754.1_ENST00000415201.1_RNA|REG3A_ENST00000409839.3_Silent_p.Q69Q	NM_138938.2	NP_620355.1	Q06141	REG3A_HUMAN	regenerating islet-derived 3 alpha	69	C-type lectin.				acute-phase response|cell proliferation|heterophilic cell-cell adhesion|multicellular organismal development	cytoplasm|extracellular space|soluble fraction	sugar binding			breast(2)|large_intestine(4)|lung(41)|prostate(2)|skin(1)	50						AGGGCCGCTTCTGGCAGGCCA	0.572000													32	76					0	0	1	0	0
FAM45A	404636	broad.mit.edu	37	10	120892117	120892117	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:120892117T>C	ENST00000361432.2	+	8	919	c.893T>C	c.(892-894)aTa>aCa	p.I298T	FAM45A_ENST00000544016.1_Missense_Mutation_p.I147T|FAM45A_ENST00000489988.1_3'UTR|FAM45A_ENST00000535029.1_3'UTR	NM_207009.2	NP_996892.1	Q8TCE6	FA45A_HUMAN	family with sequence similarity 45, member A	298										breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|ovary(2)|urinary_tract(1)	14		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0293)		AGCCACGTTATACAGGTAACT	0.522000													113	54					0	0	1	0	0
FAM47E-STBD1	100631383	broad.mit.edu	37	4	77230498	77230498	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:77230498C>T	ENST00000237642.6	+	2	1166	c.422C>T	c.(421-423)tCa>tTa	p.S141L	FAM47E-STBD1_ENST00000539752.1_5'UTR|FAM47E_ENST00000515604.1_3'UTR	NM_003943.4	NP_003934.1																					TCTGAAGTTTCAAGAAATGAA	0.428000													7	32					0	0	1	0	0
SRRT	51593	broad.mit.edu	37	7	100485992	100485992	+	Missense_Mutation	SNP	A	A	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:100485992A>C	ENST00000388793.4	+	19	2760	c.2540A>C	c.(2539-2541)aAa>aCa	p.K847T	SRRT_ENST00000432932.1_Missense_Mutation_p.K843T|SRRT_ENST00000457580.2_Missense_Mutation_p.K844T|SRRT_ENST00000347433.4_Missense_Mutation_p.K848T	NM_001128852.1|NM_015908.5	NP_001122324.1|NP_056992.4	Q9BXP5	SRRT_HUMAN	serrate RNA effector molecule homolog (Arabidopsis)	848					cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			breast(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(5)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40						TATCCTGGGAAACCTCGCAAC	0.612000													11	13					0	0	1	0	0
JAM3	83700	broad.mit.edu	37	11	134010623	134010623	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:134010623G>A	ENST00000299106.4	+	3	373	c.214G>A	c.(214-216)Gat>Aat	p.D72N	JAM3_ENST00000441717.3_Missense_Mutation_p.D72N|JAM3_ENST00000524969.1_3'UTR|JAM3_ENST00000529443.2_Missense_Mutation_p.D117N			Q9BX67	JAM3_HUMAN	junctional adhesion molecule 3	72	Ig-like V-type.				angiogenesis|blood coagulation|regulation of neutrophil chemotaxis	cell-cell contact zone|desmosome|extracellular space|integral to membrane	integrin binding			breast(1)|endometrium(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)	10	all_hematologic(175;0.127)	all_cancers(12;1.06e-21)|all_epithelial(12;3.37e-16)|all_lung(97;7.03e-06)|Lung NSC(97;1.67e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0506)|Esophageal squamous(93;0.0566)		Epithelial(10;1.55e-09)|BRCA - Breast invasive adenocarcinoma(10;1.35e-08)|all cancers(11;2.81e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00402)|Lung(977;0.245)		GAAAATTCAAGATGAACAAAC	0.438000													6	58					0	0	1	0	0
SLCO1A2	6579	broad.mit.edu	37	12	21453315	21453315	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:21453315C>T	ENST00000307378.6	-	9	1597	c.877G>A	c.(877-879)Gag>Aag	p.E293K	SLCO1A2_ENST00000458504.1_Missense_Mutation_p.E161K|SLCO1A2_ENST00000537524.1_Missense_Mutation_p.E161K|SLCO1A2_ENST00000452078.1_Missense_Mutation_p.E293K|SLCO1A2_ENST00000390670.3_Missense_Mutation_p.E291K	NM_134431.3	NP_602307.1	P46721	SO1A2_HUMAN	solute carrier organic anion transporter family, member 1A2	293					bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(2)|endometrium(2)|kidney(4)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(6)|upper_aerodigestive_tract(1)	48						TTCTTGACCTCTTCTTTTTGT	0.299000													3	15					0	0	1	0	0
WASH3P	374666	broad.mit.edu	37	15	102515299	102515299	+	RNA	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:102515299G>A	ENST00000557932.1	+	0	1145																		p.G374S(10)		central_nervous_system(1)|endometrium(6)|kidney(11)|prostate(5)|stomach(1)|urinary_tract(1)	25						TGGGGGCATCGGCAAGGCCAA	0.652000													3	17					0	0	1	0	0
KLK2	3817	broad.mit.edu	37	19	51381756	51381756	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:51381756T>C	ENST00000325321.3	+	5	952	c.727T>C	c.(727-729)Tac>Cac	p.Y243H	KLK2_ENST00000391810.2_Missense_Mutation_p.Y141H|KLK2_ENST00000358049.4_3'UTR			P20151	KLK2_HUMAN	kallikrein-related peptidase 2	243	Peptidase S1.				proteolysis		serine-type endopeptidase activity		KLK2/ETV1(3)|KLK2/ETV4(2)	large_intestine(3)|lung(6)|ovary(1)|skin(1)	11		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.00871)		GCCTGCTGTGTACACCAAGGT	0.537000			T	ETV4	prostate								124	266					0	0	1	0	0
MS4A4A	51338	broad.mit.edu	37	11	60070049	60070049	+	Silent	SNP	A	A	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:60070049A>G	ENST00000355131.3	+	6	571	c.348A>G	c.(346-348)ggA>ggG	p.G116G	MS4A4A_ENST00000337908.4_Silent_p.G135G|MS4A4A_ENST00000395016.3_Silent_p.G116G|MS4A4A_ENST00000532114.1_Intron	NM_024021.3	NP_076926.2	Q96JQ5	M4A4A_HUMAN	membrane-spanning 4-domains, subfamily A, member 4A	135						integral to membrane	receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(12)|prostate(1)|skin(4)	23						GTAGTCTAGGAATGAATATCA	0.393000													14	69					0	0	1	0	0
MCAM	4162	broad.mit.edu	37	11	119182861	119182861	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:119182861C>T	ENST00000392814.1	-	4	1620	c.891G>A	c.(889-891)gtG>gtA	p.V297V	MCAM_ENST00000264036.4_Silent_p.V348V			P43121	MUC18_HUMAN	melanoma cell adhesion molecule	348	Ig-like C2-type 1.				anatomical structure morphogenesis|cell adhesion	integral to membrane|plasma membrane				breast(2)|central_nervous_system(2)|endometrium(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(3)|skin(1)	22		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.78e-05)		CTGCGGGACTCACTCGGACGT	0.627000													15	93					0	0	1	0	0
BRDT	676	broad.mit.edu	37	1	92433810	92433810	+	Silent	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:92433810C>A	ENST00000370389.2	+	4	1143	c.219C>A	c.(217-219)atC>atA	p.I73I	BRDT_ENST00000399546.2_Silent_p.I146I|BRDT_ENST00000394530.3_Silent_p.I100I|BRDT_ENST00000402388.1_Silent_p.I146I|BRDT_ENST00000362005.3_Silent_p.I146I	NM_001242810.1	NP_001229739	Q58F21	BRDT_HUMAN	bromodomain, testis-specific	146	Bromo 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(24)|ovary(1)|prostate(4)|skin(2)|stomach(2)|urinary_tract(2)	56		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)		AGGAAAGAATCAAGAAAGGTA	0.398000													12	15					7.93312e-07	8.15946e-07	1	1	0
LYST	1130	broad.mit.edu	37	1	235972637	235972637	+	Missense_Mutation	SNP	G	G	A	rs115019462	by1000genomes	TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:235972637G>A	ENST00000389794.3	-	5	1655	c.1481C>T	c.(1480-1482)tCg>tTg	p.S494L	LYST_ENST00000389793.2_Missense_Mutation_p.S494L|LYST_ENST00000536965.1_Missense_Mutation_p.S494L			Q99698	LYST_HUMAN	lysosomal trafficking regulator	494					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TGTACACATCGAATGATGAAG	0.398000													26	47					0	0	1	0	0
LIMA1	51474	broad.mit.edu	37	12	50615999	50615999	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:50615999G>C	ENST00000341247.4	-	4	584	c.435C>G	c.(433-435)atC>atG	p.I145M	LIMA1_ENST00000394943.3_Missense_Mutation_p.I145M|LIMA1_ENST00000552823.1_De_novo_Start_InFrame|LIMA1_ENST00000552783.1_De_novo_Start_InFrame|RP3-405J10.4_ENST00000551284.1_RNA|LIMA1_ENST00000552909.1_De_novo_Start_InFrame	NM_001113546.1|NM_016357.4	NP_001107018.1|NP_057441.1	Q9UHB6	LIMA1_HUMAN	LIM domain and actin binding 1	145					actin filament bundle assembly|negative regulation of actin filament depolymerization|ruffle organization	cytoplasm|focal adhesion|stress fiber	actin filament binding|actin monomer binding|zinc ion binding			NS(1)|breast(4)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(2)	44						CACCGTCCTTGATGTGGGGAT	0.453000													11	53					0	0	1	0	0
EGFLAM	133584	broad.mit.edu	37	5	38418241	38418241	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:38418241G>C	ENST00000322350.5	+	12	1914	c.1568G>C	c.(1567-1569)aGa>aCa	p.R523T	EGFLAM_ENST00000336740.6_Missense_Mutation_p.R289T|EGFLAM_ENST00000354891.3_Missense_Mutation_p.R523T|EGFLAM_ENST00000397202.2_Intron	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	523	Laminin G-like 1.					cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					TGGTTGGTTAGAGCAACAGGG	0.512000													26	172					0	0	1	0	0
HRC	3270	broad.mit.edu	37	19	49658061	49658061	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:49658061G>C	ENST00000252825.4	-	1	620	c.434C>G	c.(433-435)tCa>tGa	p.S145*	HRC_ENST00000595625.1_Nonsense_Mutation_p.S145*	NM_002152.2	NP_002143.1	P23327	SRCH_HUMAN	histidine rich calcium binding protein	145	4 X tandem repeats, acidic.|6 X approximate tandem repeats.				muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(10)|lung(10)|ovary(1)|prostate(3)|urinary_tract(2)	34		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		GTGCTCAGCTGAGTCTTCCGT	0.582000													44	110					0	0	1	0	0
DOCK6	57572	broad.mit.edu	37	19	11332548	11332548	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:11332548G>T	ENST00000294618.7	-	28	3540	c.3529C>A	c.(3529-3531)Cca>Aca	p.P1177T	DOCK6_ENST00000319867.7_Missense_Mutation_p.P516T	NM_020812.3	NP_065863.2	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	1177					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|endometrium(11)|large_intestine(8)|liver(2)|lung(9)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	39						TGCAGCCGTGGCAAGGTATCC	0.587000													91	200					5.80972e-51	6.33708e-51	1	1	0
JAKMIP1	152789	broad.mit.edu	37	4	6107652	6107652	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:6107652G>A	ENST00000409021.3	-	3	621	c.172C>T	c.(172-174)Cgc>Tgc	p.R58C	JAKMIP1_ENST00000457227.2_Intron|JAKMIP1_ENST00000282924.5_Missense_Mutation_p.R58C|JAKMIP1_ENST00000409831.1_Missense_Mutation_p.R58C|JAKMIP1_ENST00000409371.3_Intron|JAKMIP1_ENST00000410077.2_Intron	NM_001099433.1	NP_001092903.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1	58	Mediates association with microtubules.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						TCCTGCTCGCGCTCCAGCTTC	0.672000													26	45					0	0	1	0	0
ACOT11	26027	broad.mit.edu	37	1	55066985	55066985	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:55066985G>A	ENST00000371316.3	+	9	1010	c.928G>A	c.(928-930)Gag>Aag	p.E310K	ACOT11_ENST00000481208.1_3'UTR|ACOT11_ENST00000343744.2_Missense_Mutation_p.E310K	NM_015547.3	NP_056362.1	Q8WXI4	ACO11_HUMAN	acyl-CoA thioesterase 11	310	Acyl coenzyme A hydrolase 2.				fatty acid metabolic process|intracellular signal transduction|response to cold		acyl-CoA thioesterase activity|carboxylesterase activity			NS(1)|central_nervous_system(1)|endometrium(6)|large_intestine(3)|lung(5)|ovary(1)	17						CCAGGAGGCTGAGACCCACCG	0.642000													40	99					0	0	1	0	0
LIMA1	51474	broad.mit.edu	37	12	50616215	50616215	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:50616215C>T	ENST00000341247.4	-	4	368	c.219G>A	c.(217-219)aaG>aaA	p.K73K	LIMA1_ENST00000394943.3_Silent_p.K73K|LIMA1_ENST00000552783.1_5'UTR|RP3-405J10.4_ENST00000551284.1_RNA	NM_001113546.1|NM_016357.4	NP_001107018.1|NP_057441.1	Q9UHB6	LIMA1_HUMAN	LIM domain and actin binding 1	73					actin filament bundle assembly|negative regulation of actin filament depolymerization|ruffle organization	cytoplasm|focal adhesion|stress fiber	actin filament binding|actin monomer binding|zinc ion binding			NS(1)|breast(4)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(2)	44						CCCACTTCTTCTTTAACACAG	0.498000													58	89					0	0	1	0	0
ARMC4	55130	broad.mit.edu	37	10	28151397	28151397	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:28151397C>A	ENST00000305242.5	-	18	2857	c.2765G>T	c.(2764-2766)gGa>gTa	p.G922V	ARMC4_ENST00000545014.1_Missense_Mutation_p.G447V|ARMC4_ENST00000537576.1_Missense_Mutation_p.G614V	NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	922							binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						AGGAACAACTCCATGATCTGT	0.343000													62	61					1.91123e-38	2.07842e-38	1	1	0
WNK1	65125	broad.mit.edu	37	12	862795	862795	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:862795G>T	ENST00000537687.1	+	1	707	c.64G>T	c.(64-66)Gct>Tct	p.A22S	WNK1_ENST00000315939.6_Missense_Mutation_p.A22S|WNK1_ENST00000447667.2_Missense_Mutation_p.A22S|WNK1_ENST00000535572.1_Missense_Mutation_p.A22S|WNK1_ENST00000530271.2_Missense_Mutation_p.A22S	NM_001184985.1|NM_213655.4	NP_001171914.1|NP_998820.3	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	22					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			breast(7)|central_nervous_system(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(43)|ovary(6)|prostate(3)|skin(7)|stomach(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	104	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			CTCGCCGCCGGCTCCTGCCCC	0.682000													20	37					1.10923e-09	1.15239e-09	1	1	0
NBEAL1	65065	broad.mit.edu	37	2	204078256	204078256	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:204078256C>G	ENST00000449802.1	+	54	8196	c.7863C>G	c.(7861-7863)atC>atG	p.I2621M		NM_001114132.1	NP_001107604.1	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1	2621							binding			NS(1)|breast(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|liver(1)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						ATCTCAGCATCAACCCATTAG	0.328000													14	97					0	0	1	0	0
VAV2	7410	broad.mit.edu	37	9	136804268	136804268	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:136804268A>G	ENST00000371851.1	-	2	603	c.278T>C	c.(277-279)cTg>cCg	p.L93P	VAV2_ENST00000486113.1_5'UTR|VAV2_ENST00000371850.3_Missense_Mutation_p.L93P|VAV2_ENST00000406606.3_Missense_Mutation_p.L93P			P52735	VAV2_HUMAN	vav 2 guanine nucleotide exchange factor	93	CH.				angiogenesis|apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	metal ion binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(3)|endometrium(1)|kidney(3)|large_intestine(5)|lung(13)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(1)	35				OV - Ovarian serous cystadenocarcinoma(145;3.9e-07)|Epithelial(140;2.07e-06)|all cancers(34;9.39e-06)		GGGGTCAAACAGCTCGCTGTT	0.502000													40	57					0	0	1	0	0
PSD4	23550	broad.mit.edu	37	2	113955352	113955352	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:113955352A>G	ENST00000441564.3	+	14	2568	c.2399A>G	c.(2398-2400)gAg>gGg	p.E800G	PSD4_ENST00000245796.6_Missense_Mutation_p.E829G			Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4		PH.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(13)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CTGGAGGGGGAGAGCTTGGTG	0.622000													3	107					0	0	1	0	0
SLC28A3	64078	broad.mit.edu	37	9	86917263	86917263	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:86917263G>A	ENST00000376238.4	-	5	425	c.376C>T	c.(376-378)Cac>Tac	p.H126Y	SLC28A3_ENST00000537648.1_Missense_Mutation_p.H57Y	NM_001199633.1|NM_022127.2	NP_001186562.1|NP_071410.1	Q9HAS3	S28A3_HUMAN	solute carrier family 28 (concentrative nucleoside transporter), member 3	126					nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|plasma membrane	nucleoside binding			endometrium(2)|large_intestine(6)|lung(17)|ovary(1)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31						AGGGCTCTGTGAAAGTTCAGC	0.483000													7	20					0	0	1	0	0
CABIN1	23523	broad.mit.edu	37	22	24479187	24479187	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr22:24479187G>A	ENST00000398319.2	+	20	3140	c.2755G>A	c.(2755-2757)Gta>Ata	p.V919I	CABIN1_ENST00000405822.2_Missense_Mutation_p.V869I|CABIN1_ENST00000263119.5_Missense_Mutation_p.V919I	NM_001199281.1	NP_001186210.1	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	919					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			breast(2)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(13)|liver(1)|lung(18)|ovary(5)|pancreas(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						ACAGGTGCGAGTACTCCAGAA	0.582000													3	68					0	0	1	0	0
SEC31A	22872	broad.mit.edu	37	4	83740266	83740266	+	Silent	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:83740266G>C	ENST00000432794.1	-	28	3826	c.3663C>G	c.(3661-3663)ctC>ctG	p.L1221L	SEC31A_ENST00000505984.1_Silent_p.L1154L|SEC31A_ENST00000513858.1_Silent_p.L1055L|SEC31A_ENST00000509142.1_Silent_p.L1094L|SEC31A_ENST00000326950.5_Silent_p.L1169L|SEC31A_ENST00000355196.2_Silent_p.L1208L|SEC31A_ENST00000500777.2_Silent_p.L1055L|SEC31A_ENST00000264405.5_Silent_p.L957L|SEC31A_ENST00000395310.2_Silent_p.L1208L|SEC31A_ENST00000311785.7_Silent_p.L1094L|SEC31A_ENST00000348405.4_Silent_p.L1169L|SEC31A_ENST00000505472.1_Silent_p.L1239L|SEC31A_ENST00000448323.1_Silent_p.L1208L|SEC31A_ENST00000508502.1_Silent_p.L1193L|SEC31A_ENST00000443462.2_Silent_p.L1188L			O94979	SC31A_HUMAN	SEC31 homolog A (S. cerevisiae)	1208					COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/ALK(3)|SEC31A/JAK2(4)	breast(1)	1		Hepatocellular(203;0.114)				GAACAACTTTGAGAACTGGCA	0.418000													17	30					0	0	1	0	0
NPC1	4864	broad.mit.edu	37	18	21136222	21136222	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr18:21136222T>C	ENST00000269228.5	-	8	1865	c.1311A>G	c.(1309-1311)atA>atG	p.I437M	NPC1_ENST00000540608.1_5'UTR|NPC1_ENST00000412552.2_Missense_Mutation_p.I187M	NM_000271.4	NP_000262.2	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1	437					autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(10)|lung(13)|ovary(2)|stomach(1)	38	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					GCAGTATCTGTATGTCAAGCG	0.498000													35	71					0	0	1	0	0
HGSNAT	138050	broad.mit.edu	37	8	43053085	43053085	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:43053085C>G	ENST00000458501.2	+	17	1800	c.1800C>G	c.(1798-1800)ttC>ttG	p.F600L	HGSNAT_ENST00000297798.7_Missense_Mutation_p.F304L|HGSNAT_ENST00000379644.4_Missense_Mutation_p.F572L|HGSNAT_ENST00000521576.1_Missense_Mutation_p.F289L			Q68CP4	HGNAT_HUMAN	heparan-alpha-glucosaminide N-acetyltransferase	600					lysosomal transport|protein oligomerization	integral to membrane|lysosomal membrane	heparan-alpha-glucosaminide N-acetyltransferase activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(6)	13	Prostate(17;0.0119)|Ovarian(28;0.0172)|Lung SC(25;0.184)	all_cancers(86;0.000223)|all_epithelial(80;1.61e-07)|all_lung(54;0.00021)|Lung NSC(58;0.000778)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.0777)|LUSC - Lung squamous cell carcinoma(45;0.17)			GAACCCCATTCTTTTATCCAG	0.547000													6	35					0	0	1	0	0
APBA1	320	broad.mit.edu	37	9	72091005	72091005	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:72091005G>C	ENST00000265381.4	-	3	1477	c.1255C>G	c.(1255-1257)Ctt>Gtt	p.L419V	RP11-470P21.2_ENST00000429567.2_RNA	NM_001163.3	NP_001154.2	Q02410	APBA1_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 1	419	LIN-2/CASK binding.|Pro-rich.				axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle		p.L419V(1)		endometrium(4)|kidney(2)|large_intestine(12)|lung(13)|prostate(3)|skin(3)	37						CTGGGGTGAAGAGATGTGCTT	0.498000													16	55					0	0	1	0	0
BRWD1	54014	broad.mit.edu	37	21	40590434	40590434	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr21:40590434G>T	ENST00000342449.3	-	30	3613	c.3535C>A	c.(3535-3537)Ctt>Att	p.L1179I	BRWD1_ENST00000380800.3_Missense_Mutation_p.L1179I|BRWD1-IT1_ENST00000435608.1_RNA|BRWD1_ENST00000333229.2_Missense_Mutation_p.L1179I	NM_033656.3	NP_387505.1	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	1179	Bromo 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				cervix(2)|endometrium(6)|kidney(8)|large_intestine(14)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(2)	58		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				AACTTACCAAGATTCAAAAGT	0.284000													6	27					5.18039e-06	5.31303e-06	1	1	0
KIF3B	9371	broad.mit.edu	37	20	30897794	30897794	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:30897794C>T	ENST00000375712.3	+	2	381	c.214C>T	c.(214-216)Ctg>Ttg	p.L72L		NM_004798.3	NP_004789.1	O15066	KIF3B_HUMAN	kinesin family member 3B	72	Kinesin-motor.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(5)|lung(9)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GCAGTTTGAACTGTACGATGA	0.498000													8	81					0	0	1	0	0
CA10	56934	broad.mit.edu	37	17	49825019	49825019	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:49825019G>A	ENST00000451037.2	-	4	1379	c.439C>T	c.(439-441)Ctc>Ttc	p.L147F	CA10_ENST00000442502.2_Missense_Mutation_p.L147F|CA10_ENST00000340813.6_Missense_Mutation_p.L153F|CA10_ENST00000285273.4_Missense_Mutation_p.L147F|CA10_ENST00000570565.1_Missense_Mutation_p.L72F|CA10_ENST00000571918.1_5'UTR	NM_020178.4	NP_064563.1	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	147					brain development					cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|skin(3)|stomach(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			TGTCCATTGAGGAGGTGCTCC	0.507000													38	183					0	0	1	0	0
SCARA5	286133	broad.mit.edu	37	8	27737165	27737165	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:27737165C>T	ENST00000354914.3	-	8	1757	c.1272G>A	c.(1270-1272)aaG>aaA	p.K424K	SCARA5_ENST00000380385.2_Silent_p.K199K	NM_173833.5	NP_776194.2	Q6ZMJ2	SCAR5_HUMAN	scavenger receptor class A, member 5 (putative)	424	SRCR.				cellular iron ion homeostasis|endocytosis|iron ion transmembrane transport|protein homotrimerization	integral to plasma membrane	ferritin receptor activity|scavenger receptor activity			central_nervous_system(1)|large_intestine(6)|lung(5)|prostate(3)|skin(3)	18		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)|Colorectal(74;0.228)		CTCCGTCCTTCTTGTCCCAGC	0.642000													32	118					0	0	1	0	0
TRBV6-8	28599	broad.mit.edu	37	7	142124340	142124340	+	RNA	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:142124340C>T	ENST00000390376.2	-	0	137																											ATCCATGGTTCATATCCTGGG	0.507000													90	61					0	0	1	0	0
LONP1	9361	broad.mit.edu	37	19	5719793	5719793	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:5719793G>A	ENST00000360614.3	-	1	508	c.351C>T	c.(349-351)atC>atT	p.I117I	LONP1_ENST00000540670.2_Intron|LONP1_ENST00000590729.1_Silent_p.I3I|LONP1_ENST00000593119.1_Silent_p.I53I|LONP1_ENST00000590511.1_5'UTR|LONP1_ENST00000585374.1_Silent_p.I3I	NM_004793.2	NP_004784.2	P36776	LONM_HUMAN	lon peptidase 1, mitochondrial	117					cellular chaperone-mediated protein complex assembly|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process|mitochondrial DNA metabolic process|oxidation-dependent protein catabolic process|protein homooligomerization|response to hypoxia	mitochondrial nucleoid	ADP binding|ATP binding|ATP-dependent peptidase activity|DNA polymerase binding|G-quadruplex DNA binding|mitochondrial heavy strand promoter anti-sense binding|mitochondrial light strand promoter anti-sense binding|sequence-specific DNA binding|serine-type endopeptidase activity|single-stranded DNA binding|single-stranded RNA binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						ACACATCGGGGATCGTCATGG	0.697000													42	77					0	0	1	0	0
MON1A	84315	broad.mit.edu	37	3	49949438	49949438	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:49949438C>T	ENST00000417270.1	-	4	851	c.158G>A	c.(157-159)gGc>gAc	p.G53D	MON1A_ENST00000455683.2_Intron|CTD-2330K9.3_ENST00000419183.1_Intron|MON1A_ENST00000483022.1_5'UTR|MON1A_ENST00000296473.3_Missense_Mutation_p.G142D			Q86VX9	MON1A_HUMAN	MON1 secretory trafficking family member A	45							protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(2)|prostate(1)	13				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		ACCCTCCTGGCCCGCACCTGC	0.607000													21	74					0	0	1	0	0
BSDC1	55108	broad.mit.edu	37	1	32849566	32849566	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:32849566C>T	ENST00000341071.7	-	4	284	c.273G>A	c.(271-273)atG>atA	p.M91I	BSDC1_ENST00000413080.1_Missense_Mutation_p.M74I|BSDC1_ENST00000446293.2_Missense_Mutation_p.M91I|BSDC1_ENST00000419121.2_Intron|BSDC1_ENST00000526031.1_Intron|BSDC1_ENST00000449308.1_Missense_Mutation_p.M74I|BSDC1_ENST00000455895.2_Missense_Mutation_p.M74I			Q9NW68	BSDC1_HUMAN	BSD domain containing 1	74							protein binding			breast(1)|central_nervous_system(2)|kidney(1)|lung(6)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	17		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				ACCCTTTCTTCATCTTCTCTG	0.547000													27	95					0	0	1	0	0
IFRD2	7866	broad.mit.edu	37	3	50326727	50326727	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:50326727C>T	ENST00000436390.1	-	11	1341	c.844G>A	c.(844-846)Gaa>Aaa	p.E282K	IFRD2_ENST00000429673.2_Missense_Mutation_p.E346K|IFRD2_ENST00000336089.4_Missense_Mutation_p.E448K|IFRD2_ENST00000417626.2_Missense_Mutation_p.E282K			Q12894	IFRD2_HUMAN	interferon-related developmental regulator 2	346							binding			breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)	14				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		GCAATGGTTTCACCGGCAGCG	0.607000													4	10					0	0	1	0	0
GLCE	26035	broad.mit.edu	37	15	69561321	69561321	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:69561321G>A	ENST00000261858.2	+	5	1820	c.1592G>A	c.(1591-1593)gGa>gAa	p.G531E	GLCE_ENST00000559420.2_Missense_Mutation_p.G467E	NM_015554.1	NP_056369.1	O94923	GLCE_HUMAN	glucuronic acid epimerase	531					heparan sulfate proteoglycan biosynthetic process|heparin biosynthetic process	Golgi membrane|integral to membrane	UDP-glucuronate 5'-epimerase activity			NS(1)|breast(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	18						GAAAAACTCGGAAAAGAAGCA	0.428000													19	44					0	0	1	0	0
TLCD1	116238	broad.mit.edu	37	17	27051729	27051729	+	Silent	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:27051729G>C	ENST00000292090.3	-	4	653	c.543C>G	c.(541-543)ctC>ctG	p.L181L	TLCD1_ENST00000394933.3_Silent_p.L134L	NM_138463.3	NP_612472.1	Q96CP7	TLCD1_HUMAN	TLC domain containing 1	181	TLC.					integral to membrane				breast(2)|endometrium(1)|kidney(2)|lung(2)	7	Lung NSC(42;0.00431)					CCAGGCGGAAGAGAAAGTACA	0.512000													23	94					0	0	1	0	0
PCNT	5116	broad.mit.edu	37	21	47746353	47746353	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr21:47746353G>A	ENST00000359568.5	+	2	224	c.117G>A	c.(115-117)gcG>gcA	p.A39A	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	39					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					AAAAGACGGCGAAGAGGAAGG	0.507000													28	53					0	0	1	0	0
GYS1	2997	broad.mit.edu	37	19	49473902	49473902	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:49473902G>T	ENST00000323798.3	-	14	1906	c.1710C>A	c.(1708-1710)ttC>ttA	p.F570L	GYS1_ENST00000544287.1_Missense_Mutation_p.F203L|GYS1_ENST00000263276.6_Missense_Mutation_p.F506L|GYS1_ENST00000541188.1_Missense_Mutation_p.F490L	NM_002103.4	NP_002094.2	P13807	GYS1_HUMAN	glycogen synthase 1 (muscle)	570					glucose metabolic process|glycogen biosynthetic process	cytosol	glycogen (starch) synthase activity|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000164)|all cancers(93;0.000226)|GBM - Glioblastoma multiforme(486;0.00561)|Epithelial(262;0.0286)		AACTGTAGAGGAAGGAGGTGA	0.592000											OREG0025611	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	58					2.35188e-11	2.46469e-11	1	1	0
PTRH2	51651	broad.mit.edu	37	17	57775139	57775139	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:57775139C>T	ENST00000470557.2	-	1	3647	c.201G>A	c.(199-201)atG>atA	p.M67I	PTRH2_ENST00000537860.1_Missense_Mutation_p.M67I|PTRH2_ENST00000393038.2_Missense_Mutation_p.M67I|PTRH2_ENST00000409433.2_Missense_Mutation_p.M68I			Q9Y3E5	PTH2_HUMAN	peptidyl-tRNA hydrolase 2	67					apoptosis|translation	mitochondrion	aminoacyl-tRNA hydrolase activity			large_intestine(1)	1	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					CCACAAGAATCATCTTGTACT	0.468000													36	93					0	0	1	0	0
IRAK3	11213	broad.mit.edu	37	12	66605248	66605248	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:66605248C>G	ENST00000261233.4	+	5	880	c.459C>G	c.(457-459)atC>atG	p.I153M	IRAK3_ENST00000457197.2_Missense_Mutation_p.I92M	NM_007199.2	NP_009130.2	Q9Y616	IRAK3_HUMAN	interleukin-1 receptor-associated kinase 3	153					interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|negative regulation of innate immune response|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of macrophage cytokine production|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein catabolic process|negative regulation of protein complex disassembly|negative regulation of toll-like receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of macrophage tolerance induction|positive regulation of NF-kappaB transcription factor activity|response to exogenous dsRNA|response to lipopolysaccharide|response to peptidoglycan	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein heterodimerization activity|protein homodimerization activity|protein serine/threonine kinase activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(28;0.0203)		AATCTTCCATCAGCTTTCAAA	0.343000													10	14					0	0	1	0	0
NCSTN	23385	broad.mit.edu	37	1	160328025	160328025	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:160328025C>T	ENST00000368063.1	+	18	2314	c.2034C>T	c.(2032-2034)ttC>ttT	p.F678F	NCSTN_ENST00000392212.4_Silent_p.F678F|NCSTN_ENST00000294785.5_Silent_p.F698F|NCSTN_ENST00000535857.1_Silent_p.F560F|NCSTN_ENST00000368065.4_Silent_p.F440F			Q92542	NICA_HUMAN	nicastrin	698					amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane|melanosome	protein binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|skin(2)	34	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			ATGTCCTTTTCATTGCTCCCC	0.557000													51	601					0	0	1	0	0
SLC30A6	55676	broad.mit.edu	37	2	32418957	32418957	+	Splice_Site	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:32418957G>C	ENST00000282587.5	+	8	438		c.e8-1		SLC30A6_ENST00000406369.1_Splice_Site|SLC30A6_ENST00000538303.1_Splice_Site|SLC30A6_ENST00000379343.2_Splice_Site|SLC30A6_ENST00000435660.1_Splice_Site|SLC30A6_ENST00000357055.3_Splice_Site	NM_017964.3	NP_060434.2	Q6NXT4	ZNT6_HUMAN	solute carrier family 30 (zinc transporter), member 6							Golgi membrane|integral to membrane	zinc ion transmembrane transporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(4)|lung(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					GTTCTTTTTAGGGGAAGATTA	0.363000													31	75					0	0	1	0	0
VPS11	55823	broad.mit.edu	37	11	118948319	118948319	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:118948319C>T	ENST00000300793.6	+	10	1573	c.1531C>T	c.(1531-1533)Cat>Tat	p.H511Y	VPS11_ENST00000527798.1_3'UTR	NM_021729.4	NP_068375.3	Q9H270	VPS11_HUMAN	vacuolar protein sorting 11 homolog (S. cerevisiae)	512					protein transport	endocytic vesicle|HOPS complex|late endosome membrane|lysosomal membrane	nucleotide binding|protein binding|zinc ion binding			autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)|skin(2)|urinary_tract(2)	29	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.88e-05)		CCATGCACATCATGAGTGGTA	0.517000													8	14					0	0	1	0	0
LRRC14B	389257	broad.mit.edu	37	5	195402	195402	+	Silent	SNP	T	T	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:195402T>G	ENST00000328278.3	+	2	1507	c.1479T>G	c.(1477-1479)gcT>gcG	p.A493A		NM_001080478.1	NP_001073947.1	A6NHZ5	LR14B_HUMAN	leucine rich repeat containing 14B	493										endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|skin(1)|upper_aerodigestive_tract(2)	10						AGCTTGGTGCTTTCTTGCTGC	0.483000													14	123					0	0	1	0	0
EPG5	57724	broad.mit.edu	37	18	43450624	43450624	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr18:43450624C>T	ENST00000282041.5	-	36	6167	c.6133G>A	c.(6133-6135)Gag>Aag	p.E2045K	EPG5_ENST00000585906.1_5'UTR	NM_020964.2	NP_066015.2	Q9HCE0	EPG5_HUMAN	ectopic P-granules autophagy protein 5 homolog (C. elegans)	2045					autophagy					NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(35)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	95						AGAATGAACTCTGGCATTTTG	0.488000													16	39					0	0	1	0	0
ARNT2	9915	broad.mit.edu	37	15	80767365	80767365	+	Silent	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:80767365C>G	ENST00000533983.1	+	6	729	c.390C>G	c.(388-390)ctC>ctG	p.L130L	ARNT2_ENST00000531595.3_3'UTR|ARNT2_ENST00000527771.1_Silent_p.L130L|ARNT2_ENST00000303329.4_Silent_p.L141L			Q9HBZ2	ARNT2_HUMAN	aryl-hydrocarbon receptor nuclear translocator 2	141					central nervous system development|in utero embryonic development|response to hypoxia		aryl hydrocarbon receptor binding|DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			NS(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(16)|ovary(1)|pancreas(2)|prostate(2)|skin(1)	35			BRCA - Breast invasive adenocarcinoma(143;0.134)			TGAAGCATCTCATCCTTGAAG	0.453000													6	382					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124345611	124345611	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:124345611A>G	ENST00000409039.3	+	38	6473	c.6448A>G	c.(6448-6450)Ata>Gta	p.I2150V		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2150	AAA 2 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CGTGAGTGTCATAGAACTCTA	0.483000													27	32					0	0	1	0	0
XXYLT1	152002	broad.mit.edu	37	3	194790762	194790762	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:194790762G>A	ENST00000310380.6	-	4	972	c.864C>T	c.(862-864)ttC>ttT	p.F288F	XXYLT1_ENST00000355729.4_Silent_p.F85F|XXYLT1_ENST00000429994.1_Silent_p.F142F|XXYLT1_ENST00000460582.1_5'UTR|XXYLT1_ENST00000356740.5_Silent_p.F82F|XXYLT1_ENST00000437101.1_Silent_p.F85F	NM_152531.4	NP_689744.3	Q8NBI6	CC021_HUMAN	xyloside xylosyltransferase 1	288						integral to membrane	transferase activity, transferring glycosyl groups										CCCCGCTGTTGAAGCCCGGCA	0.677000													28	131					0	0	1	0	0
GSTO1	9446	broad.mit.edu	37	10	106022765	106022765	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:106022765G>A	ENST00000539281.1	+	4	667	c.311G>A	c.(310-312)aGa>aAa	p.R104K	GSTO1_ENST00000369713.5_Missense_Mutation_p.R132K|GSTO1_ENST00000493946.1_3'UTR|GSTO1_ENST00000369710.4_Intron	NM_001191003.1	NP_001177932.1	P78417	GSTO1_HUMAN	glutathione S-transferase omega 1	132					xenobiotic metabolic process	cytosol	glutathione transferase activity|monodehydroascorbate reductase (NADH) activity			large_intestine(1)|lung(1)|stomach(1)	3		Colorectal(252;0.102)|Breast(234;0.122)		Epithelial(162;8.07e-10)|all cancers(201;2.72e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0147)	Glutathione(DB00143)	AGCTTTATTAGAAGCCAAAAT	0.368000													11	13					0	0	1	0	0
QTRT1	81890	broad.mit.edu	37	19	10818004	10818004	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:10818004G>A	ENST00000250237.5	+	4	488	c.478G>A	c.(478-480)Gac>Aac	p.D160N	QTRT1_ENST00000585885.1_3'UTR	NM_031209.2	NP_112486.1	Q9BXR0	TGT_HUMAN	queuine tRNA-ribosyltransferase 1	160					queuosine biosynthetic process	mitochondrion|nucleus|ribosome	metal ion binding|queuine tRNA-ribosyltransferase activity			large_intestine(2)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	12			Epithelial(33;1.55e-05)|all cancers(31;3.42e-05)			GCAGCTGGACGACGTGGTTAG	0.572000													39	215					0	0	1	0	0
FAM122A	116224	broad.mit.edu	37	9	71395443	71395443	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:71395443C>T	ENST00000394264.3	+	1	480	c.363C>T	c.(361-363)ttC>ttT	p.F121F	PIP5K1B_ENST00000265382.3_Intron|PIP5K1B_ENST00000541509.1_Intron	NM_138333.3	NP_612206.3	Q96E09	F122A_HUMAN	family with sequence similarity 122A	121										endometrium(1)|lung(2)	3						AGGAAAGTTTCAGCCTGAGTG	0.557000													108	173					0	0	1	0	0
MAN1B1	11253	broad.mit.edu	37	9	139981500	139981500	+	Missense_Mutation	SNP	T	T	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:139981500T>A	ENST00000371589.4	+	1	122	c.49T>A	c.(49-51)Tcg>Acg	p.S17T		NM_016219.4	NP_057303.2	Q9UKM7	MA1B1_HUMAN	mannosidase, alpha, class 1B, member 1	17					oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|endoplasmic reticulum quality control compartment|integral to membrane	alpha-mannosidase activity|calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			autonomic_ganglia(1)|central_nervous_system(2)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|ovary(2)	14	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;3.08e-05)|Epithelial(140;0.000513)		TTCCTCTCAGTCGGACTTCCT	0.692000													8	5					0	0	1	0	0
GAK	2580	broad.mit.edu	37	4	875769	875769	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:875769G>C	ENST00000314167.4	-	15	1697	c.1587C>G	c.(1585-1587)ttC>ttG	p.F529L	GAK_ENST00000511163.1_Missense_Mutation_p.F450L	NM_005255.2	NP_005246.2	O14976	GAK_HUMAN	cyclin G associated kinase	529	Phosphatase tensin-type.				cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(16)|skin(7)|urinary_tract(2)	39				Colorectal(103;0.219)		CCGCGGTGCTGAAGAGACGGC	0.642000													12	8					0	0	1	0	0
RREB1	6239	broad.mit.edu	37	6	7247274	7247274	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:7247274G>A	ENST00000379938.2	+	12	5128	c.4591G>A	c.(4591-4593)Gac>Aac	p.D1531N	RREB1_ENST00000349384.6_Missense_Mutation_p.D1476N|RREB1_ENST00000334984.6_Intron|RREB1_ENST00000379933.3_Missense_Mutation_p.D1476N	NM_001003699.3|NM_001003700.1	NP_001003699.1|NP_001003700.1	Q92766	RREB1_HUMAN	ras responsive element binding protein 1	1476					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|lung(18)|ovary(5)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				GGGCCCCTCCGACGGGGAGAG	0.672000													3	25					0	0	1	0	0
GAK	2580	broad.mit.edu	37	4	875739	875739	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:875739G>A	ENST00000314167.4	-	15	1727	c.1617C>T	c.(1615-1617)ttC>ttT	p.F539F	GAK_ENST00000511163.1_Silent_p.F460F	NM_005255.2	NP_005246.2	O14976	GAK_HUMAN	cyclin G associated kinase	539	Phosphatase tensin-type.				cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(16)|skin(7)|urinary_tract(2)	39				Colorectal(103;0.219)		GCTTCATGCTGAACATGTACA	0.652000													14	10					0	0	1	0	0
NEFH	4744	broad.mit.edu	37	22	29885744	29885744	+	Silent	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr22:29885744T>C	ENST00000310624.6	+	4	2148	c.2115T>C	c.(2113-2115)ccT>ccC	p.P705P		NM_021076.3	NP_066554.2	P12036	NFH_HUMAN	neurofilament, heavy polypeptide	711	30 X 6 AA repeats of K-S-P-[AEPV]-[EAK]- [AEVK].|Tail.				cell death|nervous system development	neurofilament				cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|skin(3)	30						CAAAGTCCCCTGAGAAGGCCA	0.562000													3	163					0	0	1	0	0
LRRC57	255252	broad.mit.edu	37	15	42840409	42840409	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:42840409G>A	ENST00000323443.2	-	2	485	c.118C>T	c.(118-120)Ctc>Ttc	p.L40F	LRRC57_ENST00000563454.1_Missense_Mutation_p.L40F|LRRC57_ENST00000397130.3_Missense_Mutation_p.L40F			Q8N9N7	LRC57_HUMAN	leucine rich repeat containing 57	40										breast(1)|kidney(1)|lung(5)|prostate(1)	8		all_cancers(109;1.99e-12)|all_epithelial(112;5.11e-11)|Lung NSC(122;4.53e-07)|all_lung(180;1.64e-06)|Melanoma(134;0.0262)		GBM - Glioblastoma multiforme(94;6.87e-07)		ATGGTCCTGAGATTGCTCGTC	0.552000													34	137					0	0	1	0	0
ZNF407	55628	broad.mit.edu	37	18	72775115	72775115	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr18:72775115C>T	ENST00000299687.5	+	8	5438	c.5438C>T	c.(5437-5439)tCc>tTc	p.S1813F		NM_017757.2	NP_060227.2	Q9C0G0	ZN407_HUMAN	zinc finger protein 407	1813					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.S1813C(1)		central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(21)|lung(23)|ovary(4)|prostate(3)|upper_aerodigestive_tract(2)	67		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		GGCATTGTTTCCAAGTCGTAC	0.557000													53	88					0	0	1	0	0
RTKN2	219790	broad.mit.edu	37	10	63995992	63995992	+	Translation_Start_Site	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:63995992C>A	ENST00000315289.2	-	0	30				RTKN2_ENST00000395265.1_Missense_Mutation_p.K173N|RTKN2_ENST00000373789.3_Missense_Mutation_p.K173N			Q8IZC4	RTKN2_HUMAN	rhotekin 2						signal transduction	intracellular				endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(3)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Prostate(12;0.0297)|all_hematologic(501;0.215)					ACACTTCCACCTTTATCTGAA	0.328000													8	24					0.335167	0.3361	1	1	0
LRRC37A4P	55073	broad.mit.edu	37	17	43587569	43587569	+	RNA	SNP	G	G	C	rs149697015	by1000genomes	TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:43587569G>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							aactccgtctgaaaagaaaag	0.443000													3	38					0	0	1	0	0
NRIP2	83714	broad.mit.edu	37	12	2944040	2944040	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:2944040G>A	ENST00000337508.4	-	1	150	c.110C>T	c.(109-111)cCc>cTc	p.P37L		NM_031474.2	NP_113662.1	Q9BQI9	NRIP2_HUMAN	nuclear receptor interacting protein 2	37					proteolysis|transcription, DNA-dependent	cytoplasm|nucleus	aspartic-type endopeptidase activity			central_nervous_system(1)|endometrium(2)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	12			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			GCTCGGTGGGGGCGTCACCGA	0.632000													44	94					0	0	1	0	0
SYCE1	93426	broad.mit.edu	37	10	135369290	135369290	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:135369290G>A	ENST00000368517.3	-	10	743	c.605C>T	c.(604-606)gCc>gTc	p.A202V	SYCE1_ENST00000432597.2_Missense_Mutation_p.A202V|SPRN_ENST00000541506.1_Intron|SYCE1_ENST00000343131.5_Missense_Mutation_p.A238V	NM_130784.2	NP_570140.1	Q8N0S2	SYCE1_HUMAN	synaptonemal complex central element protein 1	238					cell division	central element				breast(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(2)|stomach(3)|urinary_tract(1)	19		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		TTACACTGTGGCTGCAGCCTC	0.632000													52	32					0	0	1	0	0
CRYBG3	131544	broad.mit.edu	37	3	97618083	97618083	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:97618083C>T	ENST00000182096.4	+	11	2167	c.2103C>T	c.(2101-2103)atC>atT	p.I701I		NM_153605.3	NP_705833.3			beta-gamma crystallin domain containing 3											breast(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(10)|stomach(1)|upper_aerodigestive_tract(2)	32						ATAATATAATCATGTCGATAC	0.363000													41	43					0	0	1	0	0
KIAA0922	23240	broad.mit.edu	37	4	154506049	154506049	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:154506049C>T	ENST00000409663.3	+	12	1172	c.1120C>T	c.(1120-1122)Cta>Tta	p.L374L	KIAA0922_ENST00000440693.1_Silent_p.L375L|KIAA0922_ENST00000409959.3_Silent_p.L375L	NM_015196.3	NP_056011.3	A2VDJ0	T131L_HUMAN	KIAA0922	374						integral to membrane				breast(2)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(16)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	63	all_hematologic(180;0.093)	Renal(120;0.118)				CACTCCAACACTAAAAGCATG	0.393000													25	43					0	0	1	0	0
TRAV14DV4	28669	broad.mit.edu	37	14	22392709	22392709	+	RNA	SNP	A	A	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:22392709A>T	ENST00000390440.2	+	0	307																											TGACGAGCAAAATGCAACAGA	0.433000													22	112					0	0	1	0	0
PLEKHM1P	440456	broad.mit.edu	37	17	62783397	62783397	+	RNA	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:62783397G>C	ENST00000582986.1	-	0	2175					NR_024386.1																						GAACCTATGCGGAGACTCCAA	0.493000													5	43					0	0	1	0	0
FGD5	152273	broad.mit.edu	37	3	14941941	14941941	+	Silent	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:14941941C>G	ENST00000285046.5	+	8	3296	c.3186C>G	c.(3184-3186)gcC>gcG	p.A1062A	FGD5_ENST00000476851.1_3'UTR|FGD5_ENST00000543601.1_Silent_p.A821A	NM_152536.3	NP_689749.3	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	1062	DH.				actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(2)|breast(2)|endometrium(3)|kidney(5)|large_intestine(10)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(1)	54						CGGACTCCGCCGAGTACGACA	0.577000													8	39					0	0	1	0	0
DAAM2	23500	broad.mit.edu	37	6	39846247	39846247	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:39846247G>A	ENST00000538976.1	+	13	1610	c.1428G>A	c.(1426-1428)aaG>aaA	p.K476K	DAAM2_ENST00000398904.2_Silent_p.K476K|DAAM2_ENST00000274867.4_Silent_p.K476K	NM_015345.3	NP_056160.2	Q86T65	DAAM2_HUMAN	dishevelled associated activator of morphogenesis 2	476					actin cytoskeleton organization		actin binding|Rho GTPase binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(9)|lung(18)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)	49	Ovarian(28;0.0355)|Colorectal(47;0.196)					CATTGGAGAAGGAAGAGATGA	0.587000													10	13					0	0	1	0	0
SMARCA2	6595	broad.mit.edu	37	9	2159835	2159835	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:2159835C>G	ENST00000302401.3	+	2	545	c.25C>G	c.(25-27)Cgc>Ggc	p.R9G	SMARCA2_ENST00000382194.1_Intron|SMARCA2_ENST00000382185.1_5'UTR|SMARCA2_ENST00000349721.2_Intron|SMARCA2_ENST00000357248.2_Intron|SMARCA2_ENST00000382186.1_Intron|SMARCA2_ENST00000324954.5_5'UTR|SMARCA2_ENST00000382203.1_Intron			P51531	SMCA2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	0					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		ACTAGCAGCTCGCTGCTTTGC	0.388000													22	16					0	0	1	0	0
SPDYE3	441272	broad.mit.edu	37	7	99917593	99917593	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:99917593G>A	ENST00000332397.6	+	10	1814	c.1630G>A	c.(1630-1632)Gat>Aat	p.D544N	SPDYE3_ENST00000437326.2_Missense_Mutation_p.D167N	NM_001004351.4	NP_001004351.3	A6NKU9	SPDE3_HUMAN	speedy/RINGO cell cycle regulator family member E3	544								p.D544N(1)		endometrium(10)|kidney(1)|lung(8)|urinary_tract(1)	20						GTGGGCGCGAGATCGCGCCCA	0.582000													27	18					0	0	1	0	0
FGG	2266	broad.mit.edu	37	4	155533181	155533181	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:155533181G>A	ENST00000404648.3	-	3	535	c.296C>T	c.(295-297)tCa>tTa	p.S99L	FGG_ENST00000336098.3_Missense_Mutation_p.S99L|FGG_ENST00000405164.1_Missense_Mutation_p.S99L|FGG_ENST00000407946.1_Missense_Mutation_p.S99L	NM_000509.4	NP_000500.2	P02679	FIBG_HUMAN	fibrinogen gamma chain	99					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(9)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	27	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	TGGTTTTGATGATTCATCAGG	0.308000													4	21					0	0	1	0	0
TDRD6	221400	broad.mit.edu	37	6	46660819	46660819	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:46660819G>C	ENST00000544460.1	+	1	5208	c.4954G>C	c.(4954-4956)Gac>Cac	p.D1652H	TDRD6_ENST00000316081.6_Missense_Mutation_p.D1652H	NM_001168359.1	NP_001161831.1	O60522	TDRD6_HUMAN	tudor domain containing 6	1652					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			AGAGGGAAATGACTATTTCTA	0.378000													17	69					0	0	1	0	0
PAK1IP1	55003	broad.mit.edu	37	6	10697685	10697685	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:10697685G>A	ENST00000379568.3	+	2	504	c.213G>A	c.(211-213)aaG>aaA	p.K71K		NM_017906.2	NP_060376.2	Q9NWT1	PK1IP_HUMAN	PAK1 interacting protein 1	71					negative regulation of signal transduction	nucleolus|plasma membrane				kidney(1)|large_intestine(1)|lung(7)|prostate(2)|upper_aerodigestive_tract(1)	12	Ovarian(93;0.107)|Breast(50;0.137)	all_hematologic(90;0.117)				ACATGAAAAAGAAGATTGAGC	0.393000													7	106					0	0	1	0	0
SLC25A11	8402	broad.mit.edu	37	17	4841188	4841188	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:4841188C>T	ENST00000225665.7	-	8	1133	c.793G>A	c.(793-795)Gtg>Atg	p.V265M	SLC25A11_ENST00000544061.2_Missense_Mutation_p.V214M	NM_001165417.1|NM_003562.4	NP_001158889.1|NP_003553.2	Q02978	M2OM_HUMAN	solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11	265					gluconeogenesis	integral to plasma membrane|mitochondrial inner membrane	oxoglutarate:malate antiporter activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(5)	10						TTGAACAGCACGTCCTAGACA	0.627000													28	69					0	0	1	0	0
SYNGAP1	8831	broad.mit.edu	37	6	33400506	33400506	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:33400506G>A	ENST00000418600.2	+	5	533	c.432G>A	c.(430-432)acG>acA	p.T144T	SYNGAP1_ENST00000428982.2_Silent_p.T85T|SYNGAP1_ENST00000293748.5_Silent_p.T144T|SYNGAP1_ENST00000496374.1_3'UTR	NM_006772.2	NP_006763.2	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1	144					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(15)|ovary(7)|pancreas(1)|stomach(1)|urinary_tract(1)	43						TCAAACGAACGAAGTCACAAC	0.582000													24	61					0	0	1	0	0
WDR33	55339	broad.mit.edu	37	2	128482710	128482710	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:128482710G>C	ENST00000322313.4	-	9	1089	c.931C>G	c.(931-933)Ctc>Gtc	p.L311V		NM_018383.4	NP_060853.3	Q9C0J8	WDR33_HUMAN	WD repeat domain 33	311					postreplication repair|spermatogenesis	collagen|nucleus	protein binding			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		AGTTTACAGAGATGATCACGT	0.383000													9	13					0	0	1	0	0
PDE3B	5140	broad.mit.edu	37	11	14665990	14665990	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:14665990C>T	ENST00000282096.4	+	1	722	c.369C>T	c.(367-369)ttC>ttT	p.F123F	PDE3B_ENST00000455098.2_Silent_p.F123F|PDE3B_ENST00000534317.1_3'UTR	NM_000922.3	NP_000913.2	Q13370	PDE3B_HUMAN	phosphodiesterase 3B, cGMP-inhibited	123					cAMP catabolic process|insulin receptor signaling pathway|negative regulation of lipid catabolic process|platelet activation	cytosol|endoplasmic reticulum|Golgi apparatus|guanyl-nucleotide exchange factor complex|integral to membrane|microsome	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding|protein kinase B binding			NS(1)|breast(1)|endometrium(5)|kidney(3)|large_intestine(6)|lung(15)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						GCCCCCTCTTCAGCATCGCCT	0.716000													33	32					0	0	1	0	0
PLEKHG4	25894	broad.mit.edu	37	16	67314065	67314065	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:67314065C>T	ENST00000360461.5	+	1	2653	c.118C>T	c.(118-120)Cag>Tag	p.Q40*	PLEKHG4_ENST00000450733.1_Nonsense_Mutation_p.Q40*|PLEKHG4_ENST00000379344.3_Nonsense_Mutation_p.Q40*|PLEKHG4_ENST00000427155.2_Nonsense_Mutation_p.Q40*	NM_001129727.1|NM_015432.3	NP_001123199.1|NP_056247.1	Q58EX7	PKHG4_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4	40					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)|Kidney(780;0.119)		ACCTGCTTCCCAGATGCACGT	0.592000													55	50					0	0	1	0	0
ZNF462	58499	broad.mit.edu	37	9	109688717	109688717	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:109688717C>A	ENST00000277225.5	+	3	2813	c.2524C>A	c.(2524-2526)Ctt>Att	p.L842I	ZNF462_ENST00000457913.1_Missense_Mutation_p.L842I			Q96JM2	ZN462_HUMAN	zinc finger protein 462	842					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						CTCTGGAAGGCTTTACTATTG	0.423000													71	109					1.39921e-30	1.51476e-30	1	1	0
NGLY1	55768	broad.mit.edu	37	3	25770771	25770771	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:25770771C>G	ENST00000428257.1	-	10	1517	c.1410G>C	c.(1408-1410)aaG>aaC	p.K470N	NGLY1_ENST00000422724.2_3'UTR|NGLY1_ENST00000280700.5_Missense_Mutation_p.K488N|NGLY1_ENST00000417874.2_Missense_Mutation_p.K446N|NGLY1_ENST00000396649.3_Missense_Mutation_p.K488N|NGLY1_ENST00000467224.1_5'UTR	NM_001145293.1	NP_001138765.1	Q96IV0	NGLY1_HUMAN	N-glycanase 1	488	PAW.				glycoprotein catabolic process	cytoplasm	metal ion binding|peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|prostate(2)|skin(1)	18						GTTTAGAAATCTTCTCATTTT	0.313000													11	13					0	0	1	0	0
PTRF	284119	broad.mit.edu	37	17	40575088	40575088	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:40575088C>G	ENST00000357037.5	-	1	447	c.28G>C	c.(28-30)Gag>Cag	p.E10Q		NM_012232.5	NP_036364.2	Q6NZI2	PTRF_HUMAN	polymerase I and transcript release factor	10					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription initiation from RNA polymerase I promoter	caveola|cytosol|endoplasmic reticulum|microsome|mitochondrion|nucleoplasm	protein binding|rRNA primary transcript binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|urinary_tract(1)	17		all_cancers(22;0.00146)|Breast(137;0.00116)|all_epithelial(22;0.0134)		BRCA - Breast invasive adenocarcinoma(366;0.193)		AGCGGCCGCTCGACAATATAG	0.726000													3	8					0	0	1	0	0
HERC1	8925	broad.mit.edu	37	15	64010869	64010869	+	Silent	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:64010869T>C	ENST00000443617.2	-	21	3969	c.3882A>G	c.(3880-3882)tcA>tcG	p.S1294S		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	1294					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						GGTACACTTCTGATAAGTGTT	0.358000													3	8					0	0	1	0	0
TPP2	7174	broad.mit.edu	37	13	103279421	103279421	+	Silent	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:103279421C>A	ENST00000376052.3	+	7	860	c.844C>A	c.(844-846)Cgg>Agg	p.R282R	TPP2_ENST00000376065.4_Silent_p.R282R			P29144	TPP2_HUMAN	tripeptidyl peptidase II	282					proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(12)|lung(21)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	52	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					AGAACCTGAACGGAATGGGGT	0.463000													31	92					5.8336e-16	6.19444e-16	1	1	0
C15orf52	388115	broad.mit.edu	37	15	40627522	40627522	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:40627522C>T	ENST00000397536.2	-	7	847	c.812G>A	c.(811-813)gGa>gAa	p.G271E	C15orf52_ENST00000559313.1_Missense_Mutation_p.G481E			Q6ZUT6	CO052_HUMAN	chromosome 15 open reading frame 52	481										central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|urinary_tract(1)	19		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.06e-06)|Colorectal(105;0.0107)|BRCA - Breast invasive adenocarcinoma(123;0.0505)|READ - Rectum adenocarcinoma(2;0.0649)|Lung(196;0.0781)|LUAD - Lung adenocarcinoma(183;0.0841)		GAGCCCTGCTCCTCTCTGTGG	0.657000													23	108					0	0	1	0	0
LMNA	4000	broad.mit.edu	37	1	156105709	156105709	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:156105709G>A	ENST00000368300.4	+	6	1166	c.954G>A	c.(952-954)gcG>gcA	p.A318A	LMNA_ENST00000448611.2_Silent_p.A206A|LMNA_ENST00000392353.3_Silent_p.A237A|LMNA_ENST00000368297.1_Silent_p.A237A|LMNA_ENST00000368301.2_Silent_p.A318A|LMNA_ENST00000347559.2_Silent_p.A318A|LMNA_ENST00000368299.3_Silent_p.A318A|LMNA_ENST00000496738.1_3'UTR|LMNA_ENST00000473598.2_Silent_p.A219A|LMNA_ENST00000361308.4_Silent_p.A318A	NM_170707.3	NP_733821.1	P02545	LMNA_HUMAN	lamin A/C	318	Coil 2.|Rod.				cellular component disassembly involved in apoptosis|cellular response to hypoxia|establishment or maintenance of microtubule cytoskeleton polarity|muscle organ development|positive regulation of cell aging|regulation of apoptosis|regulation of cell migration	cytoplasm|lamin filament|nuclear envelope|perinuclear region of cytoplasm	protein binding|structural molecule activity			NS(1)|endometrium(1)|kidney(1)|lung(3)|ovary(4)	10	Hepatocellular(266;0.158)					CCAAGGAGGCGAAGCTTCGAG	0.657000									Werner syndrome;Hutchinson-Gilford Progeria Syndrome				19	41					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56497803	56497803	+	Missense_Mutation	SNP	T	T	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:56497803T>A	ENST00000370754.5	-	27	3554	c.3555A>T	c.(3553-3555)caA>caT	p.Q1185H	DST_ENST00000518935.1_Missense_Mutation_p.Q681H|DST_ENST00000312431.6_Missense_Mutation_p.Q1007H|DST_ENST00000446842.2_Missense_Mutation_p.Q681H|DST_ENST00000370788.2_Missense_Mutation_p.Q1007H|DST_ENST00000370769.4_Missense_Mutation_p.Q1007H|DST_ENST00000244364.6_Missense_Mutation_p.Q681H|DST_ENST00000361203.3_Missense_Mutation_p.Q1007H|DST_ENST00000370765.6_Missense_Mutation_p.Q681H|DST_ENST00000421834.2_Missense_Mutation_p.Q1007H			Q03001	DYST_HUMAN	dystonin	1007					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TACTTAGAACTTGCTGATGTT	0.373000													31	43					0	0	1	0	0
DLGAP1	9229	broad.mit.edu	37	18	3499318	3499318	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr18:3499318C>T	ENST00000315677.3	-	13	3394	c.2799G>A	c.(2797-2799)ctG>ctA	p.L933L	DLGAP1_ENST00000584874.1_Silent_p.L933L|DLGAP1_ENST00000534970.1_Silent_p.L617L|DLGAP1_ENST00000400150.3_Silent_p.L649L|DLGAP1_ENST00000400147.2_Silent_p.L631L|DLGAP1_ENST00000400155.1_Silent_p.L639L|DLGAP1_ENST00000539435.1_Silent_p.L641L|DLGAP1_ENST00000581699.1_Silent_p.L639L|DLGAP1_ENST00000400149.3_Silent_p.L623L	NM_004746.3	NP_004737.2	O14490	DLGP1_HUMAN	discs, large (Drosophila) homolog-associated protein 1	933					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	56		Colorectal(8;0.0257)				GCGAGCTCTCCAGCGAGCGCT	0.697000													3	9					0	0	1	0	0
AKR1D1	6718	broad.mit.edu	37	7	137798473	137798473	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:137798473A>G	ENST00000242375.3	+	8	935	c.893A>G	c.(892-894)gAc>gGc	p.D298G	AKR1D1_ENST00000468877.2_3'UTR|AKR1D1_ENST00000432161.1_Intron|AKR1D1_ENST00000411726.2_Missense_Mutation_p.D257G	NM_005989.3	NP_005980.1	P51857	AK1D1_HUMAN	aldo-keto reductase family 1, member D1	298					androgen metabolic process|bile acid biosynthetic process|bile acid catabolic process|C21-steroid hormone metabolic process|cholesterol catabolic process|digestion	cytosol	aldo-keto reductase (NADP) activity|delta4-3-oxosteroid 5beta-reductase activity|steroid binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(14)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	23						GAAATGAAGGACATTGAAGCC	0.388000													13	23					0	0	1	0	0
TNRC6B	23112	broad.mit.edu	37	22	40711471	40711471	+	Silent	SNP	A	A	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr22:40711471A>T	ENST00000454349.2	+	20	5074	c.4863A>T	c.(4861-4863)tcA>tcT	p.S1621S	TNRC6B_ENST00000301923.9_Silent_p.S817S|TNRC6B_ENST00000402203.1_Silent_p.S817S|TNRC6B_ENST00000335727.9_Silent_p.S1511S	NM_001162501.1	NP_001155973.1	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B	1621					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding			breast(1)	1						CACCCCGATCAGTCAGGGGGT	0.582000													39	147					0	0	1	0	0
KDM2B	84678	broad.mit.edu	37	12	121878735	121878735	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:121878735G>A	ENST00000377069.4	-	20	3693	c.3287C>T	c.(3286-3288)tCg>tTg	p.S1096L	KDM2B_ENST00000536437.1_Intron|KDM2B_ENST00000542973.1_Missense_Mutation_p.S533L|KDM2B_ENST00000377071.4_Missense_Mutation_p.S1165L	NM_001005366.1	NP_001005366.1	Q8NHM5	KDM2B_HUMAN	lysine (K)-specific demethylase 2B	1165	F-box.				embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	19						GCAAAGGGCCGAGACCGCGAT	0.637000													28	87					0	0	1	0	0
KCNH6	81033	broad.mit.edu	37	17	61623247	61623247	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:61623247G>A	ENST00000583023.1	+	14	2980	c.2969G>A	c.(2968-2970)gGg>gAg	p.G990E	KCNH6_ENST00000456941.2_Missense_Mutation_p.G901E|KCNH6_ENST00000581784.1_Missense_Mutation_p.G901E|KCNH6_ENST00000314672.5_Missense_Mutation_p.G954E	NM_030779.2	NP_110406.1	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 6	990					regulation of transcription, DNA-dependent|signal transduction					breast(2)|central_nervous_system(2)|endometrium(9)|kidney(4)|large_intestine(6)|lung(20)|ovary(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	54					Ibutilide(DB00308)	GGATTTGCAGGGAGTTGGGGC	0.567000													17	52					0	0	1	0	0
PIK3AP1	118788	broad.mit.edu	37	10	98408463	98408463	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:98408463C>G	ENST00000339364.5	-	7	1257	c.1138G>C	c.(1138-1140)Gag>Cag	p.E380Q	PIK3AP1_ENST00000371110.2_Missense_Mutation_p.E202Q|PIK3AP1_ENST00000468783.1_5'UTR	NM_152309.2	NP_689522.2	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1	380						cytoplasm|plasma membrane				NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(27)|ovary(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	52		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)		CCGTGTTTCTCAGCGATGGTG	0.572000													25	23					0	0	1	0	0
RUVBL1	8607	broad.mit.edu	37	3	127842556	127842556	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:127842556C>G	ENST00000322623.5	-	1	111	c.12G>C	c.(10-12)gaG>gaC	p.E4D	RUVBL1_ENST00000464873.1_Intron|RUVBL1_ENST00000417360.1_Missense_Mutation_p.E4D	NM_003707.2	NP_003698.1	Q9Y265	RUVB1_HUMAN	RuvB-like AAA ATPase 1	4					cell division|CenH3-containing nucleosome assembly at centromere|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|mitosis|regulation of growth|regulation of transcription from RNA polymerase II promoter|spermatogenesis|transcription, DNA-dependent	Golgi apparatus|Ino80 complex|membrane|microtubule organizing center|MLL1 complex|NuA4 histone acetyltransferase complex|nuclear matrix	ATP binding|DNA helicase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26				GBM - Glioblastoma multiforme(114;0.181)		TCTTCACCTCCTCAATCTTCA	0.612000													17	62					0	0	1	0	0
CCDC71	64925	broad.mit.edu	37	3	49201299	49201299	+	Missense_Mutation	SNP	T	T	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:49201299T>A	ENST00000321895.6	-	2	449	c.343A>T	c.(343-345)Aca>Tca	p.T115S		NM_022903.3	NP_075054.3	Q8IV32	CCD71_HUMAN	coiled-coil domain containing 71	115										endometrium(1)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)	10				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00217)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		GGAAGCAGTGTGGCCCGACCT	0.602000													43	64					0	0	1	0	0
ATF4P4	100127952	broad.mit.edu	37	11	113660357	113660357	+	RNA	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:113660357G>A	ENST00000393544.2	+	0	405																											CCTGGCAGAGGTGAAGGACTC	0.562000													8	3					0	0	1	0	0
PDZD4	57595	broad.mit.edu	37	X	153069709	153069709	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chrX:153069709G>A	ENST00000164640.4	-	8	1600	c.1409C>T	c.(1408-1410)gCc>gTc	p.A470V	PDZD4_ENST00000393758.2_Missense_Mutation_p.A395V|PDZD4_ENST00000544474.1_Missense_Mutation_p.A361V	NM_032512.2	NP_115901.2	Q76G19	PDZD4_HUMAN	PDZ domain containing 4	470						cell cortex				breast(3)|cervix(1)|endometrium(5)|lung(13)|skin(1)	23	all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					AGTGTTGTAGGCGCTGGTGCT	0.672000													23	11					0	0	1	0	0
LIAS	11019	broad.mit.edu	37	4	39471649	39471649	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:39471649G>A	ENST00000261434.3	+	8	866	c.748G>A	c.(748-750)Gat>Aat	p.D250N	LIAS_ENST00000381846.1_Missense_Mutation_p.D207N|LIAS_ENST00000513731.1_Missense_Mutation_p.D120N|LIAS_ENST00000340169.2_Missense_Mutation_p.D250N	NM_006859.2	NP_006850.2	O43766	LIAS_HUMAN	lipoic acid synthetase	250					inflammatory response|response to lipopolysaccharide|response to oxidative stress	mitochondrion	4 iron, 4 sulfur cluster binding|lipoate synthase activity|metal ion binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(2)|ovary(2)	12					Lipoic Acid(DB00166)	TAAGGTTCGTGATCCTCGGGC	0.413000													9	49					0	0	1	0	0
COASY	80347	broad.mit.edu	37	17	40716813	40716813	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:40716813G>A	ENST00000393818.2	+	4	1590	c.1134G>A	c.(1132-1134)ctG>ctA	p.L378L	COASY_ENST00000449624.1_Silent_p.L83L|COASY_ENST00000590958.1_Silent_p.L407L|COASY_ENST00000420359.1_Silent_p.L378L|COASY_ENST00000421097.2_Silent_p.L378L	NM_025233.6	NP_079509.5	Q13057	COASY_HUMAN	CoA synthase	378	DPCK.				coenzyme A biosynthetic process|pantothenate metabolic process	mitochondrial outer membrane	ATP binding|dephospho-CoA kinase activity|pantetheine-phosphate adenylyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)	21		all_cancers(22;1.06e-05)|Breast(137;0.000153)|all_epithelial(22;0.000344)		BRCA - Breast invasive adenocarcinoma(366;0.13)		CTCAGCGACTGAAGGGCCTGG	0.587000													39	73					0	0	1	0	0
ERCC2	2068	broad.mit.edu	37	19	45860556	45860556	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:45860556G>A	ENST00000391945.4	-	15	1528	c.1451C>T	c.(1450-1452)aCg>aTg	p.T484M	ERCC2_ENST00000391944.3_Missense_Mutation_p.T406M	NM_000400.3	NP_000391.1	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 2	484	Mediates interaction with MMS19.				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			large_intestine(4)|lung(2)|ovary(1)|pancreas(1)|stomach(1)	9		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		CCGTGCCAGCGTCATGGTGAA	0.652000			"""Mis, N, F, S"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				27	50					0	0	1	0	0
MFSD10	10227	broad.mit.edu	37	4	2935298	2935298	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:2935298G>A	ENST00000329687.4	-	2	798	c.264C>T	c.(262-264)ttC>ttT	p.F88F	MFSD10_ENST00000514800.1_Silent_p.F88F|MFSD10_ENST00000355443.4_Silent_p.F88F|MFSD10_ENST00000507555.1_Silent_p.F88F|MFSD10_ENST00000508221.1_Silent_p.F88F	NM_001120.4	NP_001111.3	Q14728	MFS10_HUMAN	major facilitator superfamily domain containing 10	88					apoptosis	integral to membrane	tetracycline transporter activity			breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|skin(1)	7				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		CCATACCTCCGAACAGGACAC	0.632000													15	50					0	0	1	0	0
HERC1	8925	broad.mit.edu	37	15	63908715	63908715	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:63908715C>T	ENST00000443617.2	-	75	13942	c.13855G>A	c.(13855-13857)Gag>Aag	p.E4619K		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	4619	HECT.				protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						TCCACCTCCTCCAGGTCCTCT	0.542000													25	51					0	0	1	0	0
PSAP	5660	broad.mit.edu	37	10	73581638	73581638	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:73581638T>C	ENST00000394936.3	-	8	1051	c.904A>G	c.(904-906)Att>Gtt	p.I302V	PSAP_ENST00000394934.1_Missense_Mutation_p.I304V			P07602	SAP_HUMAN	prosaposin	302					glycosphingolipid metabolic process|lipid transport|platelet activation|platelet degranulation	extracellular space|Golgi apparatus|integral to membrane|lysosomal lumen	enzyme activator activity|lipid binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	13						GGTACCTTAATGGGCTCCACC	0.527000													26	58					0	0	1	0	0
PCTP	58488	broad.mit.edu	37	17	53844767	53844767	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:53844767C>T	ENST00000576183.1	+	2	256	c.213C>T	c.(211-213)atC>atT	p.I71I	PCTP_ENST00000573500.1_Silent_p.I71I|PCTP_ENST00000268896.5_Silent_p.I71I|PCTP_ENST00000325214.6_5'UTR			Q9UKL6	PPCT_HUMAN	phosphatidylcholine transfer protein	71	START.					cytosol	phosphatidylcholine binding|phosphatidylcholine transmembrane transporter activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)	10			BRCA - Breast invasive adenocarcinoma(1;0.00207)			TGGCAGACATCTATATGGACT	0.378000													21	36					0	0	1	0	0
RRP12	23223	broad.mit.edu	37	10	99160214	99160214	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:99160214C>T	ENST00000370992.4	-	2	328	c.217G>A	c.(217-219)Gaa>Aaa	p.E73K	RRP12_ENST00000315563.6_Missense_Mutation_p.E73K|RRP12_ENST00000414986.1_Missense_Mutation_p.E73K	NM_015179.3	NP_055994.2	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog (S. cerevisiae)	73						integral to membrane|nuclear membrane|nucleolus	protein binding	p.E73K(1)		NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(2)|lung(13)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	37		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		TCCGGGGCTTCGCTTTTGCCC	0.562000													50	49					0	0	1	0	0
SERPINB9	5272	broad.mit.edu	37	6	2900817	2900817	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:2900817G>T	ENST00000380698.4	-	2	118	c.29C>A	c.(28-30)aCt>aAt	p.T10N		NM_004155.5	NP_004146.1	P50453	SPB9_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 9	10					anti-apoptosis|cellular response to estrogen stimulus|immune response|mast cell mediated immunity|regulation of proteolysis	cytosol|extracellular space|nucleus	caspase inhibitor activity|protease binding|serine-type endopeptidase inhibitor activity			breast(1)|endometrium(4)|large_intestine(3)|lung(5)|pancreas(1)|prostate(1)	15	Ovarian(93;0.0412)	all_hematologic(90;0.108)				TATGGCAAAAGTACCACTTGC	0.458000													128	234					8.06247e-56	8.80763e-56	1	1	0
NCOA3	8202	broad.mit.edu	37	20	46254142	46254142	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:46254142G>A	ENST00000372004.3	+	5	490	c.274G>A	c.(274-276)Gat>Aat	p.D92N	NCOA3_ENST00000371998.3_Missense_Mutation_p.D92N|NCOA3_ENST00000371997.3_Missense_Mutation_p.D92N|NCOA3_ENST00000341724.6_Missense_Mutation_p.D92N	NM_001174087.1|NM_001174088.1|NM_006534.3|NM_181659.2	NP_001167558.1|NP_001167559.1|NP_006525.2|NP_858045.1	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3	92					androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			breast(3)|endometrium(3)|kidney(4)|large_intestine(12)|lung(19)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						TATTTCCAATGATGATGATGT	0.368000													54	39					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196729276	196729276	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:196729276G>C	ENST00000312428.6	-	41	7203	c.7103C>G	c.(7102-7104)tCt>tGt	p.S2368C		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2368	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						ATACCCCTTAGAGATTTCAAC	0.448000													9	70					0	0	1	0	0
INPPL1	3636	broad.mit.edu	37	11	71949115	71949115	+	Silent	SNP	C	C	T	rs34634942		TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:71949115C>T	ENST00000541756.1	+	27	3786	c.2856C>T	c.(2854-2856)agC>agT	p.S952S	INPPL1_ENST00000298229.2_Silent_p.S1194S|INPPL1_ENST00000538751.1_Silent_p.S952S			O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	1194	Pro-rich.				actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						GGCGGGCCAGCGGGCTGGGCG	0.652000											OREG0021191	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	53					0	0	1	0	0
C1S	716	broad.mit.edu	37	12	7175803	7175803	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:7175803G>A	ENST00000406697.1	+	14	1867	c.1239G>A	c.(1237-1239)gtG>gtA	p.V413V	C1S_ENST00000402681.3_Silent_p.V246V|C1S_ENST00000360817.5_Silent_p.V413V|C1S_ENST00000495061.1_3'UTR|C1S_ENST00000328916.3_Silent_p.V413V			P09871	C1S_HUMAN	complement component 1, s subcomponent	413	Sushi 2.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(8)|liver(4)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	33					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	TGAATGAGGTGCTGGGCCCGG	0.552000													44	106					0	0	1	0	0
NHLRC3	387921	broad.mit.edu	37	13	39621833	39621833	+	Silent	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:39621833T>C	ENST00000379600.3	+	7	1136	c.814T>C	c.(814-816)Ttg>Ctg	p.L272L	NHLRC3_ENST00000470258.1_Silent_p.L75L|NHLRC3_ENST00000379599.2_Silent_p.L205L	NM_001012754.3	NP_001012772.1	Q5JS37	NHLC3_HUMAN	NHL repeat containing 3	272						extracellular region				breast(1)|kidney(1)|large_intestine(3)|lung(4)|skin(2)	11		Lung NSC(96;6.01e-07)|Breast(139;0.00394)|Prostate(109;0.00676)|Lung SC(185;0.0548)|Hepatocellular(188;0.114)		all cancers(112;2.37e-08)|Epithelial(112;3.14e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00101)|BRCA - Breast invasive adenocarcinoma(63;0.00335)|GBM - Glioblastoma multiforme(144;0.0128)		TGGGAAGTACTTGATTGTGGC	0.423000													23	16					0	0	1	0	0
SND1	27044	broad.mit.edu	37	7	127528008	127528008	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:127528008G>T	ENST00000354725.3	+	13	1591	c.1397G>T	c.(1396-1398)cGg>cTg	p.R466L		NM_014390.2	NP_055205.2	Q7KZF4	SND1_HUMAN	staphylococcal nuclease and tudor domain containing 1	466	TNase-like 3.				gene silencing by RNA|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	melanosome|nucleus|RNA-induced silencing complex	nuclease activity|nucleic acid binding|protein binding|transcription cofactor activity			central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	41						ATCAGATACCGGCAGGATGAT	0.488000													3	65					0.014758	0.0149027	1	1	0
FBN2	2201	broad.mit.edu	37	5	127622542	127622542	+	Splice_Site	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:127622542C>G	ENST00000508053.1	-	61	7855		c.e61-1		FBN2_ENST00000262464.4_Splice_Site			P35556	FBN2_HUMAN	fibrillin 2						bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TCATCCAGATCTAGAACaaaa	0.378000													12	23					0	0	1	0	0
CAPN1	823	broad.mit.edu	37	11	64972254	64972254	+	Silent	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:64972254C>G	ENST00000527323.1	+	10	1506	c.1266C>G	c.(1264-1266)gcC>gcG	p.A422A	CAPN1_ENST00000533129.1_Silent_p.A422A|CAPN1_ENST00000533820.1_Silent_p.A422A|CAPN1_ENST00000524773.1_Silent_p.A422A|CAPN1_ENST00000279247.6_Silent_p.A422A			P07384	CAN1_HUMAN	calpain 1, (mu/I) large subunit	422	Domain III.				positive regulation of cell proliferation|proteolysis	cytoplasm|plasma membrane	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|protein binding			breast(2)|endometrium(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(1)	13		Lung NSC(402;0.094)|Melanoma(852;0.16)		Lung(977;0.00168)|LUSC - Lung squamous cell carcinoma(976;0.00813)		TCGTGCTCGCCCTTATGCAGA	0.637000											OREG0021073	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	39	84					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16902787	16902787	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:16902787C>A	ENST00000430580.2	-	19	2981	c.2094G>T	c.(2092-2094)caG>caT	p.Q698H	NBPF1_ENST00000287968.8_Missense_Mutation_p.Q63H|NBPF1_ENST00000432949.1_Missense_Mutation_p.Q156H	NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	698						cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		GGACAAGGTGCTGTGCCAGTC	0.562000													40	1198					5.45727e-16	5.80338e-16	1	1	0
TMEM63B	55362	broad.mit.edu	37	6	44119725	44119725	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:44119725G>A	ENST00000259746.9	+	19	1999	c.1816G>A	c.(1816-1818)Gag>Aag	p.E606K	TMEM63B_ENST00000323267.6_Missense_Mutation_p.E606K			Q5T3F8	TM63B_HUMAN	transmembrane protein 63B	606						integral to membrane	nucleotide binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|pancreas(2)|prostate(2)|stomach(4)	35	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0215)			CTCGGCCGCCGAGAGGCGCAA	0.677000											OREG0017465	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	15					0	0	1	0	0
KDELC2	143888	broad.mit.edu	37	11	108357021	108357021	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:108357021G>A	ENST00000434945.2	-	2	681	c.379C>T	c.(379-381)Ccc>Tcc	p.P127S	KDELC2_ENST00000375648.1_Missense_Mutation_p.P127S|KDELC2_ENST00000323468.5_Missense_Mutation_p.P183S			Q7Z4H8	KDEL2_HUMAN	KDEL (Lys-Asp-Glu-Leu) containing 2	183						endoplasmic reticulum lumen				breast(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	13		all_cancers(61;1.38e-11)|all_epithelial(67;3.16e-07)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;6.93e-06)|BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|all cancers(92;0.00016)|OV - Ovarian serous cystadenocarcinoma(223;0.132)|Colorectal(284;0.14)		AACCTTTTGGGGACTTCTTTT	0.423000													67	76					0	0	1	0	0
OR9G4	283189	broad.mit.edu	37	11	56510978	56510978	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:56510978C>T	ENST00000302957.3	-	1	309	c.310G>A	c.(310-312)Gat>Aat	p.D104N		NM_001005284.1	NP_001005284.1	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G, member 4	104					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						ATGCGCTTATCTTCTGAGACA	0.458000													57	77					0	0	1	0	0
RPGRIP1	57096	broad.mit.edu	37	14	21792872	21792872	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:21792872C>G	ENST00000206660.6	+	14	1858	c.1858C>G	c.(1858-1860)Ctg>Gtg	p.L620V	RPGRIP1_ENST00000553500.1_3'UTR|RPGRIP1_ENST00000382933.4_Intron|RPGRIP1_ENST00000556336.1_Intron|RPGRIP1_ENST00000557771.1_Missense_Mutation_p.L582V|RPGRIP1_ENST00000400017.2_Missense_Mutation_p.L620V|RPGRIP1_ENST00000307974.4_Silent_p.L28L			Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator interacting protein 1	620					response to stimulus|visual perception	cilium				breast(3)|endometrium(2)|kidney(4)|large_intestine(11)|lung(10)|ovary(4)|pancreas(1)|prostate(3)|stomach(1)	39	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		GGATATTTCTCTGCTGCATCA	0.493000													17	85					0	0	1	0	0
OR10Z1	128368	broad.mit.edu	37	1	158576243	158576243	+	Missense_Mutation	SNP	C	C	G	rs140704584	byFrequency	TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:158576243C>G	ENST00000361284.1	+	1	15	c.15C>G	c.(13-15)aaC>aaG	p.N5K		NM_001004478.1	NP_001004478.1	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z, member 1	5					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(6)|lung(21)|pancreas(1)|prostate(3)|skin(4)	37	all_hematologic(112;0.0378)					GGCAGACCAACGTAACCTCCT	0.468000													6	66					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124330151	124330151	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:124330151G>A	ENST00000409039.3	+	30	5036	c.5011G>A	c.(5011-5013)Gac>Aac	p.D1671N		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1671	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CTGCAGAGTCGACTGGATGCT	0.532000													25	32					0	0	1	0	0
EPN3	55040	broad.mit.edu	37	17	48614133	48614133	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:48614133G>A	ENST00000268933.3	+	2	795	c.216G>A	c.(214-216)cgG>cgA	p.R72R	EPN3_ENST00000537145.1_Silent_p.R127R|EPN3_ENST00000541226.1_Silent_p.R16R	NM_017957.2	NP_060427.2	Q9H201	EPN3_HUMAN	epsin 3	72	ENTH.					clathrin-coated vesicle|nucleus|perinuclear region of cytoplasm	lipid binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(1)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	14	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;2.88e-09)			AGAACTGGCGGCACGTGTACA	0.597000													31	131					0	0	1	0	0
IQSEC3	440073	broad.mit.edu	37	12	284199	284199	+	Nonstop_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:284199G>C	ENST00000538872.1	+	14	3667	c.3549G>C	c.(3547-3549)taG>taC	p.*1183Y	RP11-598F7.6_ENST00000537295.1_lincRNA|IQSEC3_ENST00000537151.1_Intron|IQSEC3_ENST00000326261.4_Nonstop_Mutation_p.*1183Y			Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	0					regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		GCCTGGTGTAGACTCTGCCCC	0.692000													16	15					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216062088	216062088	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:216062088C>T	ENST00000366943.2	-	41	8289	c.7903G>A	c.(7903-7905)Gat>Aat	p.D2635N	USH2A_ENST00000307340.3_Missense_Mutation_p.D2635N|RP5-1111A8.3_ENST00000414995.1_RNA			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	2635	Fibronectin type-III 13.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding	p.D2635N(1)		NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GTTGGAGTATCAGAGAACAGC	0.498000										HNSCC(13;0.011)			15	21					0	0	1	0	0
MIEF2	125170	broad.mit.edu	37	17	18167285	18167285	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:18167285C>T	ENST00000323019.4	+	4	783	c.572C>T	c.(571-573)gCg>gTg	p.A191V	MIEF2_ENST00000395706.2_Missense_Mutation_p.A202V|MIEF2_ENST00000577216.1_3'UTR|MIEF2_ENST00000395704.4_Silent_p.C166C	NM_001144900.1|NM_139162.3	NP_001138372.1|NP_631901.2			mitochondrial elongation factor 2	191																	GCGGGGGCTGCGGACCATGTG	0.701000													8	17					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43816763	43816763	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:43816763G>T	ENST00000382031.1	+	5	3837	c.3806G>T	c.(3805-3807)gGa>gTa	p.G1269V	MAP1A_ENST00000300231.5_Missense_Mutation_p.G1031V|MAP1A_ENST00000399453.1_Missense_Mutation_p.G1031V			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1031						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	GACTCCTGGGGAGACACTAAG	0.562000													41	50					4.67007e-22	5.01806e-22	1	1	0
SPTBN1	6711	broad.mit.edu	37	2	54848571	54848571	+	Silent	SNP	A	A	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:54848571A>T	ENST00000333896.5	+	7	1144	c.759A>T	c.(757-759)atA>atT	p.I253I	SPTBN1_ENST00000356805.4_Silent_p.I266I	NM_178313.2	NP_842565.2	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1	266	Actin-binding.|CH 2.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			NS(1)|breast(8)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(27)|ovary(4)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	82			Lung(47;0.24)			AGAAGTCCATAATCACTTATG	0.463000													33	72					0	0	1	0	0
RFXAP	5994	broad.mit.edu	37	13	37394043	37394043	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:37394043G>A	ENST00000255476.2	+	1	683	c.549G>A	c.(547-549)ctG>ctA	p.L183L		NM_000538.3	NP_000529.1	O00287	RFXAP_HUMAN	regulatory factor X-associated protein	183						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(1)|ovary(1)	4		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)		all cancers(112;3.5e-07)|Epithelial(112;1.27e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.0069)|BRCA - Breast invasive adenocarcinoma(63;0.0116)|GBM - Glioblastoma multiforme(144;0.0405)		ACCAGGCCCTGAACTGCGGTG	0.557000													18	18					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113363413	113363413	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:113363413T>C	ENST00000297405.5	-	40	6560	c.6316A>G	c.(6316-6318)Att>Gtt	p.I2106V	CSMD3_ENST00000455883.2_Missense_Mutation_p.I2002V|CSMD3_ENST00000352409.3_Missense_Mutation_p.I2036V|CSMD3_ENST00000343508.3_Missense_Mutation_p.I2066V	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	2106	Sushi 11.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						CCTAAACAAATTGGGATTGGA	0.303000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			15	85					0	0	1	0	0
SORCS1	114815	broad.mit.edu	37	10	108338853	108338853	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:108338853G>A	ENST00000344440.6	-	26	3527	c.3528C>T	c.(3526-3528)ctC>ctT	p.L1176L	SORCS1_ENST00000263054.6_Intron|SORCS1_ENST00000369698.1_Silent_p.L711L	NM_001013031.2|NM_001206569.1|NM_001206571.1|NM_001206572.1	NP_001013049.1|NP_001193498.1|NP_001193500.1|NP_001193501.1	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	0						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		ATTTACCTATGAGCTGGGATT	0.498000													20	18					0	0	1	0	0
RAMP1	10267	broad.mit.edu	37	2	238820246	238820246	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:238820246G>T	ENST00000254661.4	+	3	400	c.268G>T	c.(268-270)Gac>Tac	p.D90Y	RAMP1_ENST00000409726.1_Missense_Mutation_p.D68Y|RAMP1_ENST00000403885.1_Missense_Mutation_p.D68Y|RAMP1_ENST00000404910.2_Missense_Mutation_p.D68Y	NM_005855.2	NP_005846.1	O60894	RAMP1_HUMAN	receptor (G protein-coupled) activity modifying protein 1	90					intracellular protein transport|regulation of G-protein coupled receptor protein signaling pathway	integral to plasma membrane	protein transporter activity			kidney(1)|large_intestine(1)|lung(2)	4		Breast(86;0.000596)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;9.56e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.49e-11)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;8.49e-08)|BRCA - Breast invasive adenocarcinoma(100;0.00013)|Lung(119;0.0119)|LUSC - Lung squamous cell carcinoma(224;0.0288)	Pramlintide(DB01278)	TGCAGAGGTGGACAGGTTCTT	0.642000													38	55					4.01765e-15	4.2474e-15	1	1	0
OR6A2	8590	broad.mit.edu	37	11	6816047	6816047	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:6816047C>T	ENST00000332601.3	-	1	1081	c.893G>A	c.(892-894)cGc>cAc	p.R298H		NM_003696.2	NP_003687.2	O95222	OR6A2_HUMAN	olfactory receptor, family 6, subfamily A, member 2	298					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(4)|pancreas(1)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	29		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CTCTTGATTGCGCAGGCAGTA	0.488000													30	73					0	0	1	0	0
CNGA2	1260	broad.mit.edu	37	X	150911821	150911821	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chrX:150911821C>T	ENST00000329903.4	+	6	879	c.846C>T	c.(844-846)atC>atT	p.I282I		NM_005140.1	NP_005131.1	Q16280	CNGA2_HUMAN	cyclic nucleotide gated channel alpha 2	282					response to stimulus|sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(4)|endometrium(4)|large_intestine(5)|lung(34)|prostate(2)	49	Acute lymphoblastic leukemia(192;6.56e-05)					TCCTCTACATCTTGGTCATCA	0.507000													90	48					0	0	1	0	0
KIT	3815	broad.mit.edu	37	4	55524222	55524222	+	Missense_Mutation	SNP	T	T	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:55524222T>G	ENST00000288135.5	+	1	138	c.41T>G	c.(40-42)cTg>cGg	p.L14R		NM_000222.2|NM_001093772.1	NP_000213.1|NP_001087241.1	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	14					male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity			NS(8)|autonomic_ganglia(1)|bone(21)|breast(2)|central_nervous_system(4)|endometrium(10)|eye(12)|genital_tract(18)|haematopoietic_and_lymphoid_tissue(1820)|kidney(17)|large_intestine(17)|lung(27)|ovary(23)|pancreas(4)|prostate(1)|salivary_gland(15)|skin(228)|soft_tissue(4117)|stomach(3)|testis(55)|thymus(7)|upper_aerodigestive_tract(1)	6411	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CTCTGCGTTCTGCTCCTACTG	0.667000		1	"""Mis, O"""		"""GIST, AML, TGCT, mastocytosis, mucosal melanoma"""	"""GIST, epithelioma"""	Piebald trait		Piebaldism;Mast Cell disease, Familial Clustering of;Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Gastrointestinal Stromal Tumors				24	31					0	0	1	0	0
RAF1	5894	broad.mit.edu	37	3	12653512	12653512	+	Missense_Mutation	SNP	A	A	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:12653512A>C	ENST00000251849.4	-	3	696	c.257T>G	c.(256-258)cTc>cGc	p.L86R	RAF1_ENST00000442415.2_Missense_Mutation_p.L86R|RAF1_ENST00000542177.1_Intron	NM_002880.3	NP_002871.1	P04049	RAF1_HUMAN	v-raf-1 murine leukemia viral oncogene homolog 1	86	RBD.				activation of MAPKK activity|apoptosis|axon guidance|cell proliferation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of protein complex assembly|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of peptidyl-serine phosphorylation|Ras protein signal transduction|synaptic transmission	cytosol|mitochondrial outer membrane|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|receptor signaling protein activity		ESRP1/RAF1(4)|RAF1/DAZL(2)|SRGAP3/RAF1(6)	biliary_tract(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)	32					Sorafenib(DB00398)	CCTCACCTTGAGTGCTTTCAT	0.488000			T	SRGAP3	pilocytic astrocytoma				Noonan syndrome				47	172					0	0	1	0	0
P2RX7	5027	broad.mit.edu	37	12	121615184	121615184	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:121615184C>T	ENST00000328963.5	+	10	1067	c.613C>T	c.(613-615)Cag>Tag	p.Q205*	P2RX7_ENST00000541446.1_Nonsense_Mutation_p.Q86*|P2RX7_ENST00000535250.1_Nonsense_Mutation_p.Q285*|P2RX7_ENST00000443520.3_3'UTR|P2RX7_ENST00000546057.1_Nonsense_Mutation_p.Q375*			A8K2Z0	A8K2Z0_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 7	375						integral to membrane	ATP binding|ion channel activity|receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(9)|skin(1)|stomach(1)	19	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CAAGTGCTGTCAGCCCTGTGT	0.532000													13	58					0	0	1	0	0
MRPL16	54948	broad.mit.edu	37	11	59578113	59578113	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:59578113G>A	ENST00000300151.4	-	1	232	c.19C>T	c.(19-21)Cgc>Tgc	p.R7C		NM_017840.3	NP_060310.1	Q9NX20	RM16_HUMAN	mitochondrial ribosomal protein L16	7							rRNA binding			central_nervous_system(1)|endometrium(1)|liver(1)|lung(8)	11						GCACTAGCGCGAGCCAGCAGC	0.652000													45	80					0	0	1	0	0
KDM4E	390245	broad.mit.edu	37	11	94759441	94759441	+	Silent	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:94759441G>C	ENST00000450979.2	+	1	1020	c.720G>C	c.(718-720)cgG>cgC	p.R240R		NM_001161630.1	NP_001155102.1	B2RXH2	KD4DL_HUMAN	lysine (K)-specific demethylase 4E	240	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(1)|endometrium(7)|kidney(1)|lung(3)	12						CCTTCCTGCGGCACAAAGTGG	0.562000													17	20					0	0	1	0	0
SKOR2	652991	broad.mit.edu	37	18	44775013	44775013	+	Missense_Mutation	SNP	A	A	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr18:44775013A>T	ENST00000425639.1	-	1	541	c.542T>A	c.(541-543)tTc>tAc	p.F181Y	SKOR2_ENST00000400404.1_Missense_Mutation_p.F181Y	NM_001278063.1	NP_001264992.1	Q2VWA4	SKOR2_HUMAN	SKI family transcriptional corepressor 2	181					negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	cytoplasm|nucleus	nucleotide binding|SMAD binding|transcription corepressor activity|transcription repressor activity			endometrium(1)	1						GTTGGGCGAGAAGTACATGTT	0.597000													4	10					0	0	1	0	0
TMPRSS7	344805	broad.mit.edu	37	3	111794169	111794169	+	Splice_Site	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:111794169C>G	ENST00000452346.2	+	15	1788	c.1785C>G	c.(1783-1785)acC>acG	p.T595T	TMPRSS7_ENST00000419127.1_Splice_Site_p.T469T			Q7RTY8	TMPS7_HUMAN	transmembrane protease, serine 7	595	LDL-receptor class A 3.				proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			breast(2)|endometrium(6)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						CCACCAAAGCCTGCAGCAGGA	0.532000													32	131					0	0	1	0	0
MPP7	143098	broad.mit.edu	37	10	28409311	28409311	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:28409311G>C	ENST00000337532.5	-	11	975	c.699C>G	c.(697-699)atC>atG	p.I233M	MPP7_ENST00000375719.3_Missense_Mutation_p.I233M|MPP7_ENST00000375732.1_Missense_Mutation_p.I233M|MPP7_ENST00000540098.1_Missense_Mutation_p.I233M|MPP7_ENST00000445954.2_Missense_Mutation_p.I108M	NM_173496.3	NP_775767.2	Q5T2T1	MPP7_HUMAN	membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)	233	SH3.				establishment of cell polarity|positive regulation of protein complex assembly|protein localization to adherens junction|tight junction assembly	MPP7-DLG1-LIN7 complex|tight junction	protein complex scaffold|protein domain specific binding|protein heterodimerization activity|signaling adaptor activity			autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|stomach(1)	22						AGAGGGCTTTGATAAACATCT	0.338000													31	36					0	0	1	0	0
MAP4K4	9448	broad.mit.edu	37	2	102480283	102480283	+	Splice_Site	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:102480283G>C	ENST00000324219.4	+	17	1941	c.1867G>C	c.(1867-1869)Gta>Cta	p.V623L	MAP4K4_ENST00000350198.4_Intron|MAP4K4_ENST00000456652.1_Intron|MAP4K4_ENST00000413150.2_Intron|MAP4K4_ENST00000347699.4_Intron|MAP4K4_ENST00000350878.4_Splice_Site_p.V518L|MAP4K4_ENST00000302217.5_Intron|MAP4K4_ENST00000425019.1_Intron			O95819	M4K4_HUMAN	mitogen-activated protein kinase kinase kinase kinase 4	558					intracellular protein kinase cascade|regulation of JNK cascade|response to stress	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(15)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						TTCTTGTAAGGTACAGTGGTC	0.458000													49	212					0	0	1	0	0
DOCK10	55619	broad.mit.edu	37	2	225751218	225751218	+	Silent	SNP	T	T	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:225751218T>A	ENST00000409592.3	-	5	542	c.429A>T	c.(427-429)tcA>tcT	p.S143S	DOCK10_ENST00000258390.7_Silent_p.S149S			Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	149							GTP binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		CAAAGGAATGTGAAGGAAGCT	0.333000													10	5					0	0	1	0	0
ANKRD36	375248	broad.mit.edu	37	2	97779539	97779539	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:97779539C>G	ENST00000420699.2	+	1	307	c.63C>G	c.(61-63)ttC>ttG	p.F21L	ANKRD36_ENST00000461153.2_Missense_Mutation_p.F21L	NM_001164315.1	NP_001157787.1	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	21										endometrium(9)|kidney(5)|liver(1)|lung(3)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	23						CGGATGGCTTCGCATTTCCCC	0.512000													54	90					0	0	1	0	0
WDR3	10885	broad.mit.edu	37	1	118494605	118494605	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:118494605G>A	ENST00000349139.5	+	17	1857	c.1810G>A	c.(1810-1812)Gca>Aca	p.A604T		NM_006784.2	NP_006775.1	Q9UNX4	WDR3_HUMAN	WD repeat domain 3							nuclear membrane|nucleolus				breast(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(9)|liver(2)|lung(22)|prostate(2)|upper_aerodigestive_tract(1)	49	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)		ATAGGATGGAGCACTCATAGC	0.383000													3	96					0	0	1	0	0
CTSG	1511	broad.mit.edu	37	14	25044606	25044606	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:25044606C>G	ENST00000216336.2	-	2	104	c.68G>C	c.(67-69)gGa>gCa	p.G23A		NM_001911.2	NP_001902.1	P08311	CATG_HUMAN	cathepsin G	23	Peptidase S1.				immune response|proteolysis	cell surface|extracellular space|plasma membrane|stored secretory granule	heparin binding|serine-type endopeptidase activity			autonomic_ganglia(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|skin(1)|urinary_tract(1)	25				GBM - Glioblastoma multiforme(265;0.0269)		CTCCCGGCCTCCGATGATCTC	0.567000													108	128					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113304838	113304838	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:113304838G>A	ENST00000297405.5	-	55	8960	c.8716C>T	c.(8716-8718)Ctt>Ttt	p.L2906F	CSMD3_ENST00000455883.2_Missense_Mutation_p.L2737F|CSMD3_ENST00000352409.3_Missense_Mutation_p.L2836F|CSMD3_ENST00000343508.3_Missense_Mutation_p.L2866F	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	2906	Sushi 19.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						CCTTGCATAAGATACCCAATA	0.438000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			49	156					0	0	1	0	0
SDHAF1	644096	broad.mit.edu	37	19	36486268	36486268	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:36486268G>C	ENST00000378887.2	+	1	179	c.92G>C	c.(91-93)cGa>cCa	p.R31P		NM_001042631.2	NP_001036096	A6NFY7	SDHF1_HUMAN	succinate dehydrogenase complex assembly factor 1	31					iron-sulfur cluster assembly|mitochondrial respiratory chain complex II assembly	mitochondrial matrix											GCCGAGGCGCGAGTGCGGGCA	0.736000													3	3					0	0	1	0	0
TRPM5	29850	broad.mit.edu	37	11	2432685	2432685	+	Silent	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:2432685C>G	ENST00000452833.1	-	18	2693	c.2685G>C	c.(2683-2685)gcG>gcC	p.A895A	TRPM5_ENST00000533060.1_Silent_p.A893A|TRPM5_ENST00000528453.1_Silent_p.A893A|TRPM5_ENST00000155858.6_Silent_p.A893A			Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel, subfamily M, member 5	893						integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(4)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(2)|urinary_tract(2)	23		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		GGTGCAGCAGCGCCTGGGTGG	0.632000													44	30					0	0	1	0	0
RBM26	64062	broad.mit.edu	37	13	79943007	79943007	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:79943007C>G	ENST00000438737.2	-	6	1193	c.753G>C	c.(751-753)ttG>ttC	p.L251F	RBM26_ENST00000267229.7_Missense_Mutation_p.L251F|RBM26_ENST00000438724.1_Missense_Mutation_p.L251F			Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	251					mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(6)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	33		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		TAGTGCTGCTCAAAGTAGGTA	0.398000													3	131					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80672819	80672819	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:80672819G>A	ENST00000458043.2	+	25	2780	c.2774G>A	c.(2773-2775)cGa>cAa	p.R925Q	OTOGL_ENST00000547103.1_Missense_Mutation_p.R925Q	NM_173591.3	NP_775862.3			otogelin-like									p.R925L(1)		breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						GTTTGTCGACGAGGAATGTTC	0.358000													35	181					0	0	1	0	0
RAPGEF6	51735	broad.mit.edu	37	5	130840372	130840372	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:130840372C>T	ENST00000509018.1	-	11	1406	c.1201G>A	c.(1201-1203)Gag>Aag	p.E401K	RAPGEF6_ENST00000308008.6_Missense_Mutation_p.E401K|RAPGEF6_ENST00000307984.5_Missense_Mutation_p.E401K|RAPGEF6_ENST00000507093.1_Missense_Mutation_p.E401K|RAPGEF6_ENST00000510071.1_Missense_Mutation_p.E401K|CTC-432M15.3_ENST00000514667.1_Missense_Mutation_p.E451K|RAPGEF6_ENST00000296859.6_Missense_Mutation_p.E401K|RAPGEF6_ENST00000512052.1_Missense_Mutation_p.E116K	NM_001164386.1|NM_016340.5	NP_001157858.1|NP_057424.3	Q8TEU7	RPGF6_HUMAN	Rap guanine nucleotide exchange factor (GEF) 6	401					Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|skin(1)|stomach(1)	31			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		TCCCGATGCTCATGTACCATA	0.383000													41	45					0	0	1	0	0
SYN3	8224	broad.mit.edu	37	22	33264982	33264982	+	Missense_Mutation	SNP	C	C	T	rs77543787	by1000genomes	TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr22:33264982C>T	ENST00000358763.2	-	5	834	c.592G>A	c.(592-594)Gtc>Atc	p.V198I	SYN3_ENST00000332840.5_Missense_Mutation_p.V198I	NM_001135774.1	NP_001129246.1	O14994	SYN3_HUMAN	synapsin III	198	C; actin-binding and synaptic-vesicle binding.				neurotransmitter secretion	cell junction|synaptic vesicle membrane	ATP binding|ligase activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33						AAGTTGTAGACGGAGTAGAGA	0.632000													19	40					0	0	1	0	0
WDR49	151790	broad.mit.edu	37	3	167277882	167277882	+	Silent	SNP	A	A	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:167277882A>G	ENST00000308378.3	-	5	926	c.621T>C	c.(619-621)ctT>ctC	p.L207L	WDR49_ENST00000476376.1_Silent_p.L32L|WDR49_ENST00000453925.2_Silent_p.L260L|WDR49_ENST00000479765.1_Intron	NM_178824.3	NP_849146.1	Q8IV35	WDR49_HUMAN	WD repeat domain 49	207										breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	50						TGCCAGTCAAAAGCCGAGTCT	0.453000													25	150					0	0	1	0	0
EOGT	285203	broad.mit.edu	37	3	69027546	69027546	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:69027546T>C	ENST00000383701.3	-	17	2117	c.1375A>G	c.(1375-1377)Agg>Ggg	p.R459G	EOGT_ENST00000295571.5_Missense_Mutation_p.R375G|EOGT_ENST00000540764.1_Missense_Mutation_p.R358G|EOGT_ENST00000540955.1_Missense_Mutation_p.R183G	NM_001278689.1	NP_001265618.1			EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase																		CCTCTCAGCCTGGCCAAGTCT	0.428000													24	100					0	0	1	0	0
ATE1	11101	broad.mit.edu	37	10	123658448	123658448	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:123658448A>G	ENST00000369043.3	-	7	936	c.850T>C	c.(850-852)Ttc>Ctc	p.F284L	ATE1_ENST00000224652.6_Intron|ATE1_ENST00000540606.1_Missense_Mutation_p.F277L|ATE1_ENST00000543447.1_Intron|ATE1_ENST00000369040.3_Missense_Mutation_p.F188L|ATE1_ENST00000535655.1_Intron|ATE1_ENST00000481784.1_Intron	NM_007041.2	NP_008972.2	O95260	ATE1_HUMAN	arginyltransferase 1	284					protein arginylation	cytoplasm|nucleus	acyltransferase activity|arginyltransferase activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	14		all_neural(114;0.061)|Lung NSC(174;0.095)|all_lung(145;0.124)|Breast(234;0.212)				GACGACTTGAACTCTGGGTCC	0.438000													44	27					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414343	20414343	+	Silent	SNP	A	A	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:20414343A>G	ENST00000380338.4	-	5	787	c.501T>C	c.(499-501)agT>agC	p.S167S	MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S164S	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	167	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S167S(19)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctactgctgctgc	0.532000			T	MLL	ALL								3	51					0	0	1	0	0
LRRTM1	347730	broad.mit.edu	37	2	80530727	80530727	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:80530727C>T	ENST00000295057.3	-	2	874	c.218G>A	c.(217-219)cGc>cAc	p.R73H	CTNNA2_ENST00000361291.4_Intron|LRRTM1_ENST00000409148.1_Missense_Mutation_p.R73H|CTNNA2_ENST00000402739.4_Intron|CTNNA2_ENST00000466387.1_Intron|CTNNA2_ENST00000540488.1_Intron|CTNNA2_ENST00000541047.1_Intron|CTNNA2_ENST00000496558.1_Intron	NM_178839.4	NP_849161.2	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	73						axon|endoplasmic reticulum membrane|growth cone|integral to membrane				NS(1)|breast(1)|endometrium(5)|large_intestine(7)|liver(1)|lung(33)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	63						GCTGTTGTAGCGCAGGGACAA	0.662000										HNSCC(69;0.2)			48	114					0	0	1	0	0
ESPNP	284729	broad.mit.edu	37	1	17026494	17026494	+	RNA	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:17026494C>G	ENST00000492551.1	-	0	1191					NR_026567.1																						CGTAGCCCGTCGTGGCCGTCG	0.726000													4	20					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209108167	209108167	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:209108167G>A	ENST00000415913.1	-	6	1063	c.682C>T	c.(682-684)Cag>Tag	p.Q228*	IDH1_ENST00000446179.1_Nonsense_Mutation_p.Q228*|IDH1_ENST00000345146.2_Nonsense_Mutation_p.Q228*	NM_001282387.1	NP_001269316.1	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	228					2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity			NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		TATATCTCCTGAAAGATGTCT	0.353000			Mis		gliobastoma								25	39					0	0	1	0	0
C9orf3	84909	broad.mit.edu	37	9	97844896	97844896	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:97844896G>A	ENST00000375315.2	+	15	2359	c.2359G>A	c.(2359-2361)Gag>Aag	p.E787K	C9orf3_ENST00000297979.5_Missense_Mutation_p.E688K|C9orf3_ENST00000433691.2_Missense_Mutation_p.E128K|C9orf3_ENST00000425634.2_Missense_Mutation_p.E149K	NM_001193329.1	NP_001180258.1	Q8N6M6	AMPO_HUMAN	chromosome 9 open reading frame 3	787					leukotriene biosynthetic process|proteolysis	cytoplasm	aminopeptidase activity|metallopeptidase activity|zinc ion binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(323;0.000275)		GATGGTGAGTGAGGACGCCAG	0.597000													32	51					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3224564	3224564	+	Silent	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:3224564G>T	ENST00000602557.1	-	21	3663	c.3108C>A	c.(3106-3108)atC>atA	p.I1036I	CSMD1_ENST00000537824.1_Silent_p.I1035I|CSMD1_ENST00000602723.1_Silent_p.I1036I|CSMD1_ENST00000400186.3_Silent_p.I1036I|CSMD1_ENST00000542608.1_Silent_p.I1035I|CSMD1_ENST00000539096.1_Silent_p.I1035I|CSMD1_ENST00000520002.1_Silent_p.I1036I			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	1036	CUB 6.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CTGAAAATGTGATATTGAAGC	0.453000													3	17					1	1	1	1	0
ZEB2	9839	broad.mit.edu	37	2	145154073	145154073	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:145154073G>C	ENST00000558170.2	-	9	4157	c.2973C>G	c.(2971-2973)atC>atG	p.I991M	ZEB2_ENST00000539609.3_Missense_Mutation_p.I967M|ZEB2_ENST00000409487.3_Missense_Mutation_p.I991M|ZEB2_ENST00000303660.4_Missense_Mutation_p.I991M	NM_014795.3	NP_055610.1	O60315	ZEB2_HUMAN	zinc finger E-box binding homeobox 2	991						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(7)|kidney(6)|large_intestine(23)|lung(45)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	107				BRCA - Breast invasive adenocarcinoma(221;0.112)		CTGTCTTCTTGATCTTTTTGC	0.443000													56	91					0	0	1	0	0
KIAA1429	25962	broad.mit.edu	37	8	95547204	95547204	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:95547204C>T	ENST00000297591.5	-	5	422	c.347G>A	c.(346-348)tGg>tAg	p.W116*	KIAA1429_ENST00000421249.2_Nonsense_Mutation_p.W116*|KIAA1429_ENST00000437199.1_Nonsense_Mutation_p.W116*	NM_015496.4	NP_056311.2	Q69YN4	VIR_HUMAN	KIAA1429	116					mRNA processing|RNA splicing	nucleus				NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(16)|lung(28)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	66	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			ACAGTTATACCAGCCTCTTAG	0.448000													41	158					0	0	1	0	0
NVL	4931	broad.mit.edu	37	1	224420909	224420909	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:224420909C>G	ENST00000281701.6	-	21	2708	c.2449G>C	c.(2449-2451)Gaa>Caa	p.E817Q	NVL_ENST00000361463.3_3'UTR|NVL_ENST00000340871.4_Missense_Mutation_p.E628Q|NVL_ENST00000469075.1_Missense_Mutation_p.E726Q|NVL_ENST00000482491.1_Missense_Mutation_p.E541Q|NVL_ENST00000391875.2_Missense_Mutation_p.E711Q	NM_002533.3	NP_002524.2	O15381	NVL_HUMAN	nuclear VCP-like	817						aggresome|cytoplasm|nucleolus	ATP binding|nucleoside-triphosphatase activity	p.E817K(1)		breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(13)|ovary(1)|prostate(1)|skin(4)|soft_tissue(1)|urinary_tract(1)	42				GBM - Glioblastoma multiforme(131;0.00501)		GTACCTTTTTCATTTCCACTC	0.383000													18	57					0	0	1	0	0
MAP4	4134	broad.mit.edu	37	3	47894824	47894824	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:47894824C>T	ENST00000426837.2	-	20	6802	c.6715G>A	c.(6715-6717)Gag>Aag	p.E2239K	MAP4_ENST00000360240.6_Missense_Mutation_p.E1094K|MAP4_ENST00000383737.4_Missense_Mutation_p.E753K|MAP4_ENST00000420772.2_Intron|MAP4_ENST00000264724.11_Missense_Mutation_p.E829K|MAP4_ENST00000441748.2_Intron|MAP4_ENST00000395734.3_Intron			P27816	MAP4_HUMAN	microtubule-associated protein 4	1094					negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(2)|pancreas(1)|skin(2)	32				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		AGAGGAGCCTCGCTGCCACCG	0.652000													5	8					0	0	1	0	0
RANBP2	5903	broad.mit.edu	37	2	109398640	109398640	+	Silent	SNP	A	A	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:109398640A>G	ENST00000283195.6	+	27	8943	c.8817A>G	c.(8815-8817)aaA>aaG	p.K2939K		NM_006267.4	NP_006258.3	P49792	RBP2_HUMAN	RAN binding protein 2	2939	RanBD1 4.				carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(34)	NS(1)|biliary_tract(1)|breast(3)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(21)|large_intestine(19)|lung(51)|pancreas(1)|prostate(8)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	129						AGAGAGCCAAACTTTATAGAT	0.363000													17	28					0	0	1	0	0
AKAP5	9495	broad.mit.edu	37	14	64936344	64936344	+	Missense_Mutation	SNP	T	T	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:64936344T>G	ENST00000394718.4	+	2	1610	c.1232T>G	c.(1231-1233)cTg>cGg	p.L411R	ZBTB25_ENST00000555424.1_Intron|AKAP5_ENST00000320636.5_Missense_Mutation_p.L411R|ZBTB25_ENST00000555220.1_Intron	NM_004857.3	NP_004848.3	P24588	AKAP5_HUMAN	A kinase (PRKA) anchor protein 5						energy reserve metabolic process|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting|regulation of insulin secretion|signal transduction|synaptic transmission	cytosol	adenylate cyclase binding|calmodulin binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(4)|stomach(1)	13				all cancers(60;0.00749)|OV - Ovarian serous cystadenocarcinoma(108;0.0095)|BRCA - Breast invasive adenocarcinoma(234;0.0449)		ATAGAACAGCTGGTTAATGAA	0.348000													19	84					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79295384	79295384	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:79295384C>T	ENST00000264895.6	+	25	3570	c.3130C>T	c.(3130-3132)Cat>Tat	p.H1044Y	FRAS1_ENST00000325942.6_Missense_Mutation_p.H1044Y	NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	1043					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						CTTTGCAGATCATGCAAAGCA	0.507000													28	111					0	0	1	0	0
PILRB	29990	broad.mit.edu	37	7	99954465	99954465	+	Translation_Start_Site	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:99954465C>A	ENST00000610247.1	+	0	2372				PILRB_ENST00000452089.1_De_novo_Start_OutOfFrame|STAG3L5P-PVRIG2P-PILRB_ENST00000310771.4_RNA|PILRB_ENST00000448382.1_Nonsense_Mutation_p.S81*|PILRB_ENST00000444073.1_De_novo_Start_OutOfFrame			Q9UKJ0	PILRB_HUMAN	paired immunoglobin-like type 2 receptor beta						activation of transmembrane receptor protein tyrosine kinase activity	integral to plasma membrane	protein binding|receptor activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	13	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GGGAGGCTGTCGTGGCAGTCC	0.587000													8	4					3.07112e-06	3.15424e-06	1	1	0
PDZRN3	23024	broad.mit.edu	37	3	73432821	73432821	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:73432821C>T	ENST00000263666.4	-	10	3010	c.2896G>A	c.(2896-2898)Gag>Aag	p.E966K	PDZRN3_ENST00000462146.2_Missense_Mutation_p.E623K|PDZRN3_ENST00000466780.1_Missense_Mutation_p.E623K|PDZRN3_ENST00000535920.1_Missense_Mutation_p.E688K|PDZRN3_ENST00000479530.1_Missense_Mutation_p.E683K	NM_015009.1	NP_055824.1	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	966							ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(31)|ovary(4)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		ATCTTCATCTCGCTCACCGCG	0.667000													27	138					0	0	1	0	0
CNRIP1	25927	broad.mit.edu	37	2	68544244	68544244	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:68544244C>T	ENST00000409862.1	-	3	556	c.375G>A	c.(373-375)atG>atA	p.M125I	CNRIP1_ENST00000409559.3_Intron|CNRIP1_ENST00000263655.3_Intron|CNRIP1_ENST00000481714.1_Intron			Q96F85	CNRP1_HUMAN	cannabinoid receptor interacting protein 1	0							protein binding			kidney(1)|large_intestine(5)|liver(1)|lung(1)|skin(1)	9						CTGTGGTTTCCATTTTCCATG	0.463000													42	113					0	0	1	0	0
AKAP13	11214	broad.mit.edu	37	15	86122380	86122380	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:86122380G>A	ENST00000394518.2	+	7	1176	c.1081G>A	c.(1081-1083)Gag>Aag	p.E361K	RP11-815J21.2_ENST00000561409.1_RNA|AKAP13_ENST00000361243.2_Missense_Mutation_p.E361K	NM_001270546.1|NM_007200.4	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	361					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						AAGCATAGTTGAGGAGGAGAA	0.493000													11	52					0	0	1	0	0
COQ3	51805	broad.mit.edu	37	6	99823966	99823966	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:99823966G>A	ENST00000254759.3	-	5	603	c.579C>T	c.(577-579)gtC>gtT	p.V193V	COQ3_ENST00000369242.1_Intron|COQ3_ENST00000369240.1_Intron	NM_017421.3	NP_059117.3	Q9NZJ6	COQ3_HUMAN	coenzyme Q3 methyltransferase	193					glycerol metabolic process|ubiquinone biosynthetic process	mitochondrial matrix	2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity|3-demethylubiquinone-9 3-O-methyltransferase activity|hexaprenyldihydroxybenzoate methyltransferase activity			cervix(1)|lung(5)|upper_aerodigestive_tract(2)	8		all_cancers(76;1.24e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.00716)|Colorectal(196;0.0691)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0625)		TCTTATCCAGGACTGGATCAA	0.443000													32	134					0	0	1	0	0
HERC1	8925	broad.mit.edu	37	15	63948074	63948074	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:63948074G>A	ENST00000443617.2	-	50	10038	c.9951C>T	c.(9949-9951)ctC>ctT	p.L3317L		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	3317					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						CAATTCCTCGGAGAAAGCTGG	0.443000													11	8					0	0	1	0	0
CPNE4	131034	broad.mit.edu	37	3	131415421	131415421	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:131415421C>G	ENST00000512055.1	-	9	2598	c.472G>C	c.(472-474)Gag>Cag	p.E158Q	CPNE4_ENST00000511604.1_Missense_Mutation_p.E158Q|CPNE4_ENST00000512332.1_Missense_Mutation_p.E176Q|CPNE4_ENST00000502818.1_Missense_Mutation_p.E176Q|CPNE4_ENST00000429747.1_Missense_Mutation_p.E158Q			Q96A23	CPNE4_HUMAN	copine IV	158	C2 2.									central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|liver(1)|lung(16)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	39						AATGCAAGCTCAACATAGTCG	0.408000													60	51					0	0	1	0	0
PVRL3	25945	broad.mit.edu	37	3	110830952	110830952	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:110830952T>C	ENST00000485303.1	+	2	511	c.236T>C	c.(235-237)tTa>tCa	p.L79S	PVRL3_ENST00000493615.1_Missense_Mutation_p.L56S|PVRL3_ENST00000319792.3_Missense_Mutation_p.L79S|PVRL3_ENST00000488016.1_3'UTR	NM_001243286.1|NM_015480.2	NP_001230215.1|NP_056295.1	Q9NQS3	PVRL3_HUMAN	poliovirus receptor-related 3	79	Ig-like V-type.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane	cell adhesion molecule binding|protein homodimerization activity			breast(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(3)	19						TTAAAGTGTTTAATTGAAGTA	0.388000													9	43					0	0	1	0	0
MCAM	4162	broad.mit.edu	37	11	119183625	119183625	+	Silent	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:119183625C>G	ENST00000392814.1	-	1	1170	c.441G>C	c.(439-441)tcG>tcC	p.S147S	MCAM_ENST00000264036.4_Silent_p.S198S			P43121	MUC18_HUMAN	melanoma cell adhesion molecule	198	Ig-like V-type 2.				anatomical structure morphogenesis|cell adhesion	integral to membrane|plasma membrane				breast(2)|central_nervous_system(2)|endometrium(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(3)|skin(1)	22		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.78e-05)		ACAAACCACTCGACTCCACAG	0.562000													18	94					0	0	1	0	0
ARAP3	64411	broad.mit.edu	37	5	141033813	141033813	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:141033813G>A	ENST00000239440.4	-	33	4404	c.4339C>T	c.(4339-4341)Caa>Taa	p.Q1447*	ARAP3_ENST00000508305.1_Nonsense_Mutation_p.Q1278*|ARAP3_ENST00000513878.1_Nonsense_Mutation_p.Q1096*|ARAP3_ENST00000512390.1_5'UTR	NM_022481.5	NP_071926.4	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	1447					cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			NS(1)|breast(7)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)	53						AGAAAGGGTTGATCCAATGAC	0.602000													36	44					0	0	1	0	0
MADD	8567	broad.mit.edu	37	11	47350217	47350217	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:47350217A>G	ENST00000342922.4	+	32	4981	c.4624A>G	c.(4624-4626)Att>Gtt	p.I1542V	MADD_ENST00000311027.5_Missense_Mutation_p.I1601V|MADD_ENST00000349238.3_Missense_Mutation_p.I1562V|MADD_ENST00000407859.3_Missense_Mutation_p.I1519V|MADD_ENST00000395336.3_Silent_p.K1577K|MADD_ENST00000402799.1_Missense_Mutation_p.I1499V|MADD_ENST00000402192.2_Missense_Mutation_p.I1541V|MADD_ENST00000406482.1_Silent_p.K1475K|MADD_ENST00000395344.3_Missense_Mutation_p.I1495V	NM_130470.2	NP_569826.2	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain	1601					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			breast(7)|central_nervous_system(2)|endometrium(9)|kidney(3)|large_intestine(19)|lung(26)|ovary(6)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	84				Lung(87;0.182)		AGTTCCTGAAATTAAAGAAGT	0.577000													13	43					0	0	1	0	0
SYDE2	84144	broad.mit.edu	37	1	85624533	85624533	+	Missense_Mutation	SNP	T	T	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:85624533T>A	ENST00000341460.5	-	7	3534	c.3485A>T	c.(3484-3486)gAt>gTt	p.D1162V		NM_032184.1	NP_115560.1	Q5VT97	SYDE2_HUMAN	synapse defective 1, Rho GTPase, homolog 2 (C. elegans)	1162					activation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	Rho GTPase activator activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|ovary(1)	20				all cancers(265;0.0126)|Epithelial(280;0.0336)		GTTTTTTCGATCCACTGTAGA	0.363000													5	9					0	0	1	0	0
ROR1	4919	broad.mit.edu	37	1	64643839	64643839	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:64643839G>A	ENST00000371079.1	+	9	2490	c.2115G>A	c.(2113-2115)gtG>gtA	p.V705V	ROR1_ENST00000545203.1_Silent_p.V156V	NM_005012.3	NP_005003.2	Q01973	ROR1_HUMAN	receptor tyrosine kinase-like orphan receptor 1	705	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			breast(7)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(14)|lung(10)|ovary(6)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	51						TTGAGATGGTGAGAAAACGGC	0.458000													23	58					0	0	1	0	0
PRICKLE2	166336	broad.mit.edu	37	3	64084988	64084988	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:64084988C>T	ENST00000295902.6	-	8	2859	c.2274G>A	c.(2272-2274)caG>caA	p.Q758Q	PRICKLE2_ENST00000564377.1_Silent_p.Q814Q|PRICKLE2-AS1_ENST00000476308.1_RNA|RP11-129B22.1_ENST00000482609.1_RNA	NM_198859.3	NP_942559.1	Q7Z3G6	PRIC2_HUMAN	prickle homolog 2 (Drosophila)	758						cytoplasm|nuclear membrane	zinc ion binding			breast(2)|endometrium(1)|large_intestine(9)|liver(1)|lung(10)|ovary(4)|prostate(2)|skin(2)|stomach(1)	32		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)		CAAAGGCATTCTGCAAAGCCA	0.587000													10	41					0	0	1	0	0
RSRC2	65117	broad.mit.edu	37	12	122991412	122991412	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:122991412T>C	ENST00000331738.7	-	9	1239	c.1094A>G	c.(1093-1095)aAt>aGt	p.N365S	RSRC2_ENST00000354654.2_Missense_Mutation_p.N317S|RSRC2_ENST00000392442.2_5'UTR	NM_023012.5	NP_075388.2	Q7L4I2	RSRC2_HUMAN	arginine/serine-rich coiled-coil 2	365										breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|skin(2)|urinary_tract(2)	24	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.14e-05)|Epithelial(86;0.000183)|BRCA - Breast invasive adenocarcinoma(302;0.201)		AAATTTGACATTTTGGTCCTT	0.343000													34	51					0	0	1	0	0
MAP2K3	5606	broad.mit.edu	37	17	21205466	21205466	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:21205466G>T	ENST00000342679.4	+	6	660	c.411G>T	c.(409-411)tgG>tgT	p.W137C	MAP2K3_ENST00000316920.6_Missense_Mutation_p.W108C|MAP2K3_ENST00000361818.5_Missense_Mutation_p.W108C	NM_145109.2	NP_659731.1	P46734	MP2K3_HUMAN	mitogen-activated protein kinase kinase 3	137	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of transcription, DNA-dependent|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity								COAD - Colon adenocarcinoma(3;0.0131)|Colorectal(15;0.0553)		GAGACGTGTGGATCTGCATGG	0.597000													15	77					1.96292e-10	2.04518e-10	1	1	0
PCDH8	5100	broad.mit.edu	37	13	53418738	53418738	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:53418738C>A	ENST00000377942.3	-	3	3373	c.3170G>T	c.(3169-3171)gGc>gTc	p.G1057V	PCDH8_ENST00000338862.4_Missense_Mutation_p.G960V	NM_002590.3	NP_002581.2	O95206	PCDH8_HUMAN	protocadherin 8	1057					cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(23)|ovary(1)|skin(1)|urinary_tract(1)	36		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		CAGGTACCTGCCAGGAGGGGA	0.547000													38	39					3.09479e-21	3.31551e-21	1	1	0
FREM1	158326	broad.mit.edu	37	9	14740152	14740152	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:14740152C>G	ENST00000380881.4	-	37	7153	c.6338G>C	c.(6337-6339)tGg>tCg	p.W2113S	FREM1_ENST00000380880.3_Missense_Mutation_p.W2112S|FREM1_ENST00000422223.2_Missense_Mutation_p.W2112S|FREM1_ENST00000380894.1_Missense_Mutation_p.W648S			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	2112	C-type lectin.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		CTTGCCTATCCAAAAGGACTT	0.498000													31	170					0	0	1	0	0
DENND5B	160518	broad.mit.edu	37	12	31632937	31632937	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:31632937C>A	ENST00000389082.5	-	3	754	c.490G>T	c.(490-492)Gaa>Taa	p.E164*	DENND5B_ENST00000536562.1_Nonsense_Mutation_p.E199*|DENND5B_ENST00000354285.4_Nonsense_Mutation_p.E186*|DENND5B_ENST00000306833.6_Nonsense_Mutation_p.E199*|DENND5B_ENST00000545147.1_Intron	NM_144973.3	NP_659410.3	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	164						integral to membrane				NS(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						GTATCTCCTTCATCAAGACTA	0.423000													40	79					1.76056e-25	1.89457e-25	1	1	0
ZYX	7791	broad.mit.edu	37	7	143079495	143079495	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:143079495G>A	ENST00000322764.5	+	3	708	c.363G>A	c.(361-363)ccG>ccA	p.P121P	ZYX_ENST00000477373.1_Intron|ZYX_ENST00000392910.2_5'UTR|ZYX_ENST00000449423.2_Silent_p.P65P	NM_001010972.1|NM_003461.4	NP_001010972.1|NP_003452.1	Q15942	ZYX_HUMAN	zyxin	121	Pro-rich.				cell adhesion|cell-cell signaling|interspecies interaction between organisms|signal transduction	cell-cell adherens junction|cytoplasm|focal adhesion|integral to plasma membrane|nucleus|stress fiber	protein binding|zinc ion binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(8)|pancreas(1)	17	Melanoma(164;0.205)					CGCCTCCTCCGGAGGAGGAGG	0.697000													14	17					0	0	1	0	0
FAM120AOS	158293	broad.mit.edu	37	9	96212868	96212868	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:96212868C>A	ENST00000375412.5	-	2	1459	c.577G>T	c.(577-579)Gga>Tga	p.G193*	FAM120AOS_ENST00000423591.1_Nonsense_Mutation_p.G11*|FAM120AOS_ENST00000479094.1_5'UTR	NM_198841.2	NP_942138.2	Q5T036	F120S_HUMAN	family with sequence similarity 120A opposite strand	193										kidney(1)|large_intestine(1)|lung(3)|skin(1)	6						CATCCTGCTCCTCTACAGAGG	0.493000													8	27					0.000274275	0.000279311	1	1	0
STX8	9482	broad.mit.edu	37	17	9153949	9153949	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:9153949C>T	ENST00000306357.4	-	8	1084	c.657G>A	c.(655-657)gtG>gtA	p.V219V	STX8_ENST00000574431.1_Silent_p.V108V	NM_004853.2	NP_004844.1	Q9UNK0	STX8_HUMAN	syntaxin 8						transport	endoplasmic reticulum|integral to plasma membrane				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|skin(1)|urinary_tract(1)	12						GCAGTAAAATCACCATGATCA	0.463000													7	14					0	0	1	0	0
FANCD2	2177	broad.mit.edu	37	3	10138051	10138051	+	Silent	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:10138051C>G	ENST00000287647.3	+	42	4173	c.4080C>G	c.(4078-4080)ctC>ctG	p.L1360L	FANCD2_ENST00000383807.1_Silent_p.L1360L|FANCD2OS_ENST00000524279.1_Intron|FANCD2_ENST00000383806.1_3'UTR|FANCD2_ENST00000419585.1_Silent_p.L1360L	NM_033084.3	NP_149075.2	Q9BXW9	FACD2_HUMAN	Fanconi anemia, complementation group D2	1360					DNA repair|response to gamma radiation	nucleoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	51				OV - Ovarian serous cystadenocarcinoma(96;0.148)		TGCCTCTGCTCAAAAAGACCC	0.423000			"""D, Mis, N, F"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				48	58					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133721430	133721430	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:133721430C>T	ENST00000409261.1	-	8	815	c.442G>A	c.(442-444)Gag>Aag	p.E148K	NCKAP5_ENST00000405974.3_Missense_Mutation_p.E148K|NCKAP5_ENST00000409213.1_Missense_Mutation_p.E148K|NCKAP5_ENST00000317721.6_Missense_Mutation_p.E148K	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	148							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						CTCTCTTCCTCTGACAGCTTT	0.403000													14	83					0	0	1	0	0
EHD2	30846	broad.mit.edu	37	19	48229178	48229178	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:48229178C>T	ENST00000263277.3	+	4	863	c.612C>T	c.(610-612)atC>atT	p.I204I	CTD-2571L23.8_ENST00000599924.1_lincRNA|EHD2_ENST00000538399.1_Silent_p.I68I	NM_014601.3	NP_055416.2	Q9NZN4	EHD2_HUMAN	EH-domain containing 2	204					blood coagulation|endocytic recycling	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding			endometrium(3)|large_intestine(7)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	19		all_cancers(25;6.74e-07)|all_lung(116;2.02e-05)|Lung NSC(112;3.77e-05)|all_epithelial(76;4.89e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		OV - Ovarian serous cystadenocarcinoma(262;0.000336)|all cancers(93;0.000415)|Epithelial(262;0.0132)|GBM - Glioblastoma multiforme(486;0.0537)		CAGAGGCCATCGGCGCGTTGC	0.637000													19	32					0	0	1	0	0
TROAP	10024	broad.mit.edu	37	12	49724323	49724323	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:49724323G>T	ENST00000551245.1	+	13	1806	c.1695G>T	c.(1693-1695)gaG>gaT	p.E565D	TROAP_ENST00000257909.3_Missense_Mutation_p.E565D|TROAP_ENST00000547923.1_Missense_Mutation_p.E273D			Q12815	TROAP_HUMAN	trophinin associated protein	565	4 X 33 AA approximate tandem repeats.|Cys-rich.				cell adhesion	cytoplasm				breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	32						GTGAGCCTGAGATACCGGAGT	0.592000													15	56					4.14922e-12	4.36091e-12	1	1	0
SF3B3	23450	broad.mit.edu	37	16	70602260	70602260	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:70602260C>A	ENST00000302516.5	+	22	3238	c.3027C>A	c.(3025-3027)ttC>ttA	p.F1009L		NM_012426.4	NP_036558.3	Q15393	SF3B3_HUMAN	splicing factor 3b, subunit 3, 130kDa	1009					protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			breast(2)|endometrium(8)|kidney(2)|large_intestine(8)|liver(3)|lung(21)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	53		Ovarian(137;0.0694)				AAGAAAGTTTCATCTGGGTTC	0.433000													40	51					1.96642e-18	2.09732e-18	1	1	0
LAMA2	3908	broad.mit.edu	37	6	129687428	129687428	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:129687428G>C	ENST00000421865.2	+	33	4831	c.4782G>C	c.(4780-4782)atG>atC	p.M1594I		NM_000426.3|NM_001079823.1	NP_000417|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	1594	Domain II and I.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		AGATGGTCATGAGCATCAACC	0.488000													28	82					0	0	1	0	0
THOP1	7064	broad.mit.edu	37	19	2808407	2808407	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:2808407G>C	ENST00000307741.6	+	9	1623	c.1420G>C	c.(1420-1422)Gag>Cag	p.E474Q	THOP1_ENST00000586677.1_Missense_Mutation_p.E353Q|THOP1_ENST00000591149.1_3'UTR	NM_003249.3	NP_003240.1	P52888	THOP1_HUMAN	thimet oligopeptidase 1	474					proteolysis	cytoplasm	metal ion binding|metalloendopeptidase activity|protein binding			NS(1)|central_nervous_system(1)|endometrium(1)|lung(8)|ovary(2)|skin(1)	14				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTACTTCCATGAGTTTGGCCA	0.692000													7	39					0	0	1	0	0
GOLGA3	2802	broad.mit.edu	37	12	133384936	133384936	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:133384936G>C	ENST00000204726.3	-	5	1277	c.719C>G	c.(718-720)tCa>tGa	p.S240*	GOLGA3_ENST00000456883.2_Nonsense_Mutation_p.S240*|GOLGA3_ENST00000537452.1_Nonsense_Mutation_p.S240*|GOLGA3_ENST00000450791.2_Nonsense_Mutation_p.S240*|GOLGA3_ENST00000545875.1_Nonsense_Mutation_p.S240*	NM_005895.3	NP_005886.2	Q08378	GOGA3_HUMAN	golgin A3	240	Golgi-targeting domain.				intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		GATTTTGCTTGATTTGGAAGT	0.532000													89	126					0	0	1	0	0
MICU2	221154	broad.mit.edu	37	13	22178097	22178097	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:22178097C>G	ENST00000382374.4	-	1	256	c.191G>C	c.(190-192)aGt>aCt	p.S64T		NM_152726.2	NP_689939.1			mitochondrial calcium uptake 2																		GACTGTAAAACTGCCATCCCG	0.672000													18	98					0	0	1	0	0
ZNF823	55552	broad.mit.edu	37	19	11832850	11832850	+	Missense_Mutation	SNP	T	T	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:11832850T>G	ENST00000341191.6	-	4	1652	c.1499A>C	c.(1498-1500)gAg>gCg	p.E500A	ZNF823_ENST00000545749.1_Missense_Mutation_p.E318A	NM_001080493.2	NP_001073962.1	P16415	ZN823_HUMAN	zinc finger protein 823	500					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|upper_aerodigestive_tract(4)	26						TGTTTTACACTCATAAGGTTT	0.378000										HNSCC(68;0.2)			22	28					0	0	1	0	0
PPIB	5479	broad.mit.edu	37	15	64455081	64455081	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:64455081C>T	ENST00000300026.3	-	1	323	c.105G>A	c.(103-105)gaG>gaA	p.E35E	PPIB_ENST00000558492.1_5'UTR	NM_000942.4	NP_000933.1	P23284	PPIB_HUMAN	peptidylprolyl isomerase B (cyclophilin B)	35					protein folding	endoplasmic reticulum lumen|melanosome	peptide binding|peptidyl-prolyl cis-trans isomerase activity|unfolded protein binding			kidney(2)|large_intestine(2)|lung(6)	10					L-Proline(DB00172)	CCTTCTTCTTCTCATCGGCCG	0.667000													8	23					0	0	1	0	0
ZNF516	9658	broad.mit.edu	37	18	74091492	74091492	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr18:74091492C>G	ENST00000443185.2	-	4	2895	c.2578G>C	c.(2578-2580)Gcc>Ccc	p.A860P	ZNF516_ENST00000524431.2_5'UTR	NM_014643.3	NP_055458.1	Q92618	ZN516_HUMAN	zinc finger protein 516	860					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		ATGCTAGCGGCTTTTGTGACC	0.617000													22	140					0	0	1	0	0
ZNRD1-AS1	80862	broad.mit.edu	37	6	29974630	29974630	+	RNA	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:29974630G>T	ENST00000376797.3	-	0	1346				HLA-J_ENST00000462773.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA|ZNRD1-AS1_ENST00000420251.1_RNA|ZNRD1-AS1_ENST00000448093.1_RNA																							GGGCCGCGGGGAGCCCAGCTT	0.697000													11	18					0.00010058	0.000102863	1	1	0
ARFIP1	27236	broad.mit.edu	37	4	153831239	153831239	+	Silent	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:153831239G>T	ENST00000451320.2	+	9	1154	c.990G>T	c.(988-990)ctG>ctT	p.L330L	ARFIP1_ENST00000405727.2_Silent_p.L298L|ARFIP1_ENST00000356064.3_Silent_p.L298L|ARFIP1_ENST00000353617.2_Silent_p.L330L|ARFIP1_ENST00000429148.2_Silent_p.L150L			P53367	ARFP1_HUMAN	ADP-ribosylation factor interacting protein 1	330	AH.				intracellular protein transport|regulation of protein secretion	cytosol|Golgi membrane			ARFIP1/FHDC1(2)	cervix(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|urinary_tract(1)	14	all_hematologic(180;0.093)					ACAATCAGCTGGTCCTTTTCC	0.403000													68	104					1.4051e-37	1.52572e-37	1	1	0
SCRN3	79634	broad.mit.edu	37	2	175263091	175263091	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:175263091C>G	ENST00000272732.6	+	2	162	c.80C>G	c.(79-81)tCa>tGa	p.S27*	SCRN3_ENST00000409673.3_Intron	NM_001193528.1|NM_024583.4	NP_001180457.1|NP_078859.2	Q0VDG4	SCRN3_HUMAN	secernin 3	27					proteolysis		dipeptidase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|urinary_tract(3)	13			OV - Ovarian serous cystadenocarcinoma(117;0.229)			GGAAAAAATTCAGATAGACTC	0.343000													18	96					0	0	1	0	0
CELF5	60680	broad.mit.edu	37	19	3290311	3290311	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:3290311C>T	ENST00000541430.2	+	11	1189	c.1153C>T	c.(1153-1155)Cgg>Tgg	p.R385W	CELF5_ENST00000292672.2_Silent_p.F423F	NM_001172673.1	NP_001166144.1	Q8N6W0	CELF5_HUMAN	CUGBP, Elav-like family member 5	0					mRNA processing	cytoplasm|nucleus	nucleotide binding|RNA binding			kidney(1)|large_intestine(2)|lung(7)|ovary(2)|skin(1)	13						TCCTACCCTTCGGCAATATCA	0.577000													25	93					0	0	1	0	0
XAF1	54739	broad.mit.edu	37	17	6659401	6659401	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:6659401G>A	ENST00000361842.3	+	1	243	c.4G>A	c.(4-6)Gaa>Aaa	p.E2K	XAF1_ENST00000438512.1_Missense_Mutation_p.E2K|XAF1_ENST00000441631.1_Missense_Mutation_p.E2K|XAF1_ENST00000576459.1_3'UTR|XAF1_ENST00000346752.4_Missense_Mutation_p.E2K	NM_017523.3	NP_059993.2	Q6GPH4	XAF1_HUMAN	XIAP associated factor 1	2					apoptosis|type I interferon-mediated signaling pathway	mitochondrion|nucleus	zinc ion binding			large_intestine(2)|lung(2)|prostate(1)|urinary_tract(1)	6						GCAGAACATGGAAGGAGACTT	0.537000													86	43					0	0	1	0	0
BHLHE22	27319	broad.mit.edu	37	8	65494338	65494338	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:65494338G>A	ENST00000321870.1	+	1	1525	c.991G>A	c.(991-993)Gct>Act	p.A331T	RP11-21C4.1_ENST00000517909.1_RNA	NM_152414.4	NP_689627.1	Q8NFJ8	BHE22_HUMAN	basic helix-loop-helix family, member e22	331	Ala-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|central_nervous_system(1)|lung(1)|prostate(1)|skin(1)	5						AGCGGCAGCAGCTGCTGCCCT	0.741000													4	5					0	0	1	0	0
ZNF451	26036	broad.mit.edu	37	6	57015563	57015563	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:57015563G>A	ENST00000370706.4	+	11	2899	c.2655G>A	c.(2653-2655)atG>atA	p.M885I	RP11-203B9.4_ENST00000589549.1_RNA|RP11-203B9.4_ENST00000586053.1_RNA|ZNF451_ENST00000357489.3_Intron|RP11-203B9.4_ENST00000589263.1_RNA|RP11-203B9.4_ENST00000585792.1_RNA|RP11-203B9.4_ENST00000416069.2_RNA|ZNF451_ENST00000491832.2_Missense_Mutation_p.M885I|RP11-203B9.4_ENST00000587815.1_RNA|RP11-203B9.4_ENST00000591553.1_RNA|RP11-203B9.4_ENST00000588811.1_RNA|RP11-203B9.4_ENST00000592500.1_RNA|RP11-203B9.4_ENST00000586432.1_RNA|RP11-203B9.4_ENST00000592038.1_RNA|RP11-203B9.4_ENST00000586668.1_RNA	NM_001031623.2	NP_001026794.1	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451	885					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			TGCGAACCATGACTCATATAG	0.363000													29	78					0	0	1	0	0
POTEF	728378	broad.mit.edu	37	2	130878029	130878029	+	Silent	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:130878029G>C	ENST00000357462.5	-	1	153	c.60C>G	c.(58-60)ctC>ctG	p.L20L	POTEF_ENST00000361163.4_Silent_p.L20L|POTEF_ENST00000360967.5_Silent_p.L20L|POTEF_ENST00000409914.2_Silent_p.L20L			A5A3E0	POTEF_HUMAN	POTE ankyrin domain family, member F	20						cell cortex	ATP binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(28)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	53						TCTTGCTCCTGAGACCAAATG	0.557000													23	146					0	0	1	0	0
GLCE	26035	broad.mit.edu	37	15	69561007	69561007	+	Silent	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:69561007G>C	ENST00000261858.2	+	5	1506	c.1278G>C	c.(1276-1278)gtG>gtC	p.V426V	GLCE_ENST00000559420.2_Silent_p.V362V|GLCE_ENST00000559500.1_3'UTR	NM_015554.1	NP_056369.1	O94923	GLCE_HUMAN	glucuronic acid epimerase	426					heparan sulfate proteoglycan biosynthetic process|heparin biosynthetic process	Golgi membrane|integral to membrane	UDP-glucuronate 5'-epimerase activity			NS(1)|breast(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	18						CAATTATGGTGACCCGTAAGT	0.488000													29	48					0	0	1	0	0
LATS1	9113	broad.mit.edu	37	6	150023160	150023160	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:150023160G>A	ENST00000543571.1	-	2	650	c.103C>T	c.(103-105)Cgg>Tgg	p.R35W	LATS1_ENST00000392273.3_Missense_Mutation_p.R35W|LATS1_ENST00000253339.5_Missense_Mutation_p.R35W	NM_004690.3	NP_004681.1	O95835	LATS1_HUMAN	large tumor suppressor kinase 1	35					cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			central_nervous_system(1)|lung(5)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		AGGGATTCCCGAATTTCTTGT	0.423000													16	79					0	0	1	0	0
RRAGC	64121	broad.mit.edu	37	1	39325198	39325200	+	In_Frame_Del	DEL	CCG	CCG	-	rs113599946		TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:39325198_39325200delCCG	ENST00000373001.3	-	1	295_297	c.119_121delCGG	c.(118-123)gcgggc>ggc	p.A40del		NM_022157.2	NP_071440.1	Q9HB90	RRAGC_HUMAN	Ras-related GTP binding C	40					apoptosis|cell growth|cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade|RNA splicing|small GTPase mediated signal transduction|transcription, DNA-dependent	lysosome|nucleus	GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein heterodimerization activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(2)|ovary(1)	10	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)				acccctccgcccgccgccgccgc	0.714													2	4	---	---	---	---					
NOS1AP	9722	broad.mit.edu	37	1	162326888	162326890	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:162326888_162326890delCAG	ENST00000361897.5	+	8	1303_1305	c.901_903delCAG	c.(901-903)cagdel	p.Q306del	NOS1AP_ENST00000530878.1_In_Frame_Del_p.Q301del	NM_001164757.1|NM_014697.2	NP_001158229.1|NP_055512.1	O75052	CAPON_HUMAN	nitric oxide synthase 1 (neuronal) adaptor protein	306	Poly-Gln.				regulation of apoptosis|regulation of nitric oxide biosynthetic process|regulation of nitric-oxide synthase activity		nitric-oxide synthase binding|PDZ domain binding			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(12)|skin(1)|upper_aerodigestive_tract(2)	32	all_hematologic(112;0.203)		BRCA - Breast invasive adenocarcinoma(70;0.0537)			gcagctcctccagcagcAGCAGC	0.611													8	273	---	---	---	---					
FOSL2	2355	broad.mit.edu	37	2	28635076	28635076	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:28635076delC	ENST00000264716.4	+	4	1605	c.742delC	c.(742-744)cccfs	p.P248fs	FOSL2_ENST00000379619.1_Frame_Shift_Del_p.P240fs|FOSL2_ENST00000545753.1_Frame_Shift_Del_p.P209fs	NM_005253.3	NP_005244.1	P15408	FOSL2_HUMAN	FOS-like antigen 2	248					cell death|regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(1)|large_intestine(3)|lung(1)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	14	Acute lymphoblastic leukemia(172;0.155)					TGTCATCAAGCCCATCAGCAT	0.652													22	65	---	---	---	---					
CHPF	79586	broad.mit.edu	37	2	220406623	220406638	+	Frame_Shift_Del	DEL	GGTGTCAGGCACCAGG	GGTGTCAGGCACCAGG	-			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:220406623_220406638delGGTGTCAGGCACCAGG	ENST00000243776.6	-	2	836_851	c.588_603delCCTGGTGCCTGACACC	c.(586-603)ttcctggtgcctgacaccfs	p.FLVPDT196fs	CHPF_ENST00000535926.1_Frame_Shift_Del_p.FLVPDT34fs|CHPF_ENST00000373891.2_Frame_Shift_Del_p.FLVPDT196fs	NM_024536.5	NP_078812	Q8IZ52	CHSS2_HUMAN	chondroitin polymerizing factor	196						Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity|protein binding	p.P199P(1)		central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)	21		Renal(207;0.0183)		Epithelial(149;3.02e-08)|all cancers(144;3.41e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		CGGTGTAGGTGGTGTCAGGCACCAGGAAGAACCAGT	0.681											OREG0015229	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	19	---	---	---	---					
RP11-649A16.1	0	broad.mit.edu	37	3	146995077	146995077	+	RNA	DEL	A	A	-			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:146995077delA	ENST00000473299.1	-	0	132																											TCTGGACTGtaaaaaaaaaaa	0.294													2	4	---	---	---	---					
RP11-379F4.4	0	broad.mit.edu	37	3	158481390	158481390	+	RNA	DEL	G	G	-			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:158481390delG	ENST00000468242.1	+	0	431				RP11-379F4.4_ENST00000465477.1_RNA																							CAGTGGCCCTGGCAGCAAATC	0.443													2	4	---	---	---	---					
PODXL	5420	broad.mit.edu	37	7	131241030	131241035	+	In_Frame_Del	DEL	GGCGAC	GGCGAC	-	rs11277659		TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:131241030_131241035delGGCGAC	ENST00000541194.1	-	1	341_346	c.84_89delGTCGCC	c.(82-90)ccgtcgccc>ccc	p.28_30PSP>P	PODXL_ENST00000322985.9_In_Frame_Del_p.28_30PSP>P|PODXL_ENST00000378555.3_In_Frame_Del_p.28_30PSP>P|PODXL_ENST00000465001.1_Intron|PODXL_ENST00000537928.1_In_Frame_Del_p.28_30PSP>P	NM_001018111.2	NP_001018121.1	O00592	PODXL_HUMAN	podocalyxin-like	28					cell adhesion|epithelial tube formation|negative regulation of cell-cell adhesion|positive regulation of cell migration|positive regulation of cell-cell adhesion mediated by integrin|regulation of microvillus assembly	actin cytoskeleton|apical plasma membrane|centrosome|filopodium|integral to plasma membrane|lamellipodium|membrane raft|microvillus membrane|nucleolus|ruffle		p.P30_S31delPS(2)		NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	24	Melanoma(18;0.162)					ATTCTGGGAGggcgacggcgacggcg	0.748													6	2	---	---	---	---					
SYNPO2L	79933	broad.mit.edu	37	10	75406489	75406493	+	Frame_Shift_Del	DEL	GCCCC	GCCCC	-			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:75406489_75406493delGCCCC	ENST00000394810.2	-	4	3066_3070	c.2917_2921delGGGGC	c.(2917-2922)ggggcafs	p.GA973fs	SYNPO2L_ENST00000372873.4_Frame_Shift_Del_p.GA749fs	NM_001114133.1	NP_001107605.1	Q9H987	SYP2L_HUMAN	synaptopodin 2-like	973						cytoplasm|cytoskeleton	actin binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Prostate(51;0.0112)					CTGGTGCCCTGCCCCAGGCCTCCAC	0.595													35	169	---	---	---	---					
ARHGAP20	57569	broad.mit.edu	37	11	110582896	110582897	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:110582896_110582897insA	ENST00000260283.4	-	2	342_343	c.58_59insT	c.(58-60)tccfs	p.S20fs	ARHGAP20_ENST00000533353.1_Intron|ARHGAP20_ENST00000527598.1_Intron|ARHGAP20_ENST00000528829.1_Intron	NM_020809.3	NP_065860.2	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	20					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(18)|lung(13)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	60		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		TCCTGTCAGGGAAGAGGAGCGC	0.658													19	34	---	---	---	---					
KLRD1	3824	broad.mit.edu	37	12	10464092	10464100	+	In_Frame_Del	DEL	TGGGTTGGG	TGGGTTGGG	-			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:10464092_10464100delTGGGTTGGG	ENST00000381908.3	+	4	453_461	c.193_201delTGGGTTGGG	c.(193-201)tgggttgggdel	p.WVG65del	KLRD1_ENST00000336164.4_In_Frame_Del_p.WVG65del|KLRD1_ENST00000543420.1_In_Frame_Del_p.WVG65del|KLRD1_ENST00000350274.5_In_Frame_Del_p.WVG34del|KLRD1_ENST00000538997.1_3'UTR|KLRD1_ENST00000381907.4_In_Frame_Del_p.WVG65del|KLRD1_ENST00000543777.1_In_Frame_Del_p.WVG44del			Q13241	KLRD1_HUMAN	killer cell lectin-like receptor subfamily D, member 1	65					cell surface receptor linked signaling pathway|regulation of immune response	integral to membrane|plasma membrane	sugar binding|transmembrane receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(2)	10						CCAAGAAAAATGGGTTGGGTACCGGTGCA	0.402													15	101	---	---	---	---					
CAND1	55832	broad.mit.edu	37	12	67696105	67696119	+	In_Frame_Del	DEL	AGTGATGATGAATAC	AGTGATGATGAATAC	-			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:67696105_67696119delAGTGATGATGAATAC	ENST00000545606.1	+	8	1440_1454	c.1003_1017delAGTGATGATGAATAC	c.(1003-1017)agtgatgatgaatacdel	p.SDDEY335del		NM_018448.3	NP_060918.2	Q86VP6	CAND1_HUMAN	cullin-associated and neddylation-dissociated 1	335	Asp-rich.				cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(12)|prostate(1)|skin(2)|stomach(1)	35			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)		ACCCTTAGGGAGTGATGATGAATACAGTGATGATG	0.358													10	179	---	---	---	---					
SLC9A7P1	121456	broad.mit.edu	37	12	98850758	98850758	+	RNA	DEL	C	C	-			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:98850758delC	ENST00000554295.1	-	0	165					NR_033801.1																						TCGACCGCCGCCCCAGAGGAG	0.687													2	4	---	---	---	---					
RB1	5925	broad.mit.edu	37	13	48937042	48937043	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:48937042_48937043insA	ENST00000267163.4	+	8	948_949	c.810_811insA	c.(811-813)acafs	p.T271fs		NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1	271					androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(6)|p.L267fs*3(1)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TAGAAAATGATACAAGAATTAT	0.342		6	"""D, Mis, N, F, S"""		"""retinoblastoma, sarcoma, breast, small cell lung"""	"""retinoblastoma, sarcoma, breast, small cell lung"""			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			40	49	---	---	---	---					
IPO5	3843	broad.mit.edu	37	13	98652878	98652880	+	In_Frame_Del	DEL	ATT	ATT	-			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:98652878_98652880delATT	ENST00000261574.5	+	13	1321_1323	c.1141_1143delATT	c.(1141-1143)attdel	p.I381del	IPO5_ENST00000490680.1_In_Frame_Del_p.I363del|IPO5_ENST00000539640.1_In_Frame_Del_p.I238del	NM_002271.4	NP_002262.3	O00410	IPO5_HUMAN	importin 5	363					interspecies interaction between organisms|NLS-bearing substrate import into nucleus|ribosomal protein import into nucleus	cytoplasm|nuclear pore|nucleolus	GTPase inhibitor activity|protein transporter activity|Ran GTPase binding			breast(2)|endometrium(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	27						CAAGGAACACATTATGCAAATGC	0.414													36	97	---	---	---	---					
NIN	51199	broad.mit.edu	37	14	51237206	51237208	+	In_Frame_Del	DEL	AGG	AGG	-			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:51237206_51237208delAGG	ENST00000245441.5	-	12	1522_1524	c.1332_1334delCCT	c.(1330-1335)atcctg>atg	p.444_445IL>M	NIN_ENST00000382043.4_In_Frame_Del_p.444_445IL>M|NIN_ENST00000324330.9_In_Frame_Del_p.444_445IL>M|NIN_ENST00000530997.2_In_Frame_Del_p.444_445IL>M|NIN_ENST00000382041.3_In_Frame_Del_p.444_445IL>M|NIN_ENST00000453196.1_In_Frame_Del_p.444_445IL>M|NIN_ENST00000389868.3_In_Frame_Del_p.444_445IL>M	NM_020921.3	NP_065972	Q8N4C6	NIN_HUMAN	ninein (GSK3B interacting protein)	444					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(13)|lung(16)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	71	all_epithelial(31;0.00244)|Breast(41;0.127)					TGCCTGCTGCAGGATCTGCTCTC	0.448			T	PDGFRB	MPD								14	55	---	---	---	---					
TAOK2	9344	broad.mit.edu	37	16	29994974	29994988	+	Splice_Site	DEL	ACCGCCTCCCTGGTG	ACCGCCTCCCTGGTG	-	rs61737875		TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:29994974_29994988delACCGCCTCCCTGGTG	ENST00000308893.4	+	13	2454_2465	c.1411_1422delACCGCCTCCCTGGTG	c.(1411-1422)accgcctccctgdel	p.TASL471del	TAOK2_ENST00000543033.1_Splice_Site_p.TASL471del|TAOK2_ENST00000416441.2_Splice_Site_p.TASL298del|TAOK2_ENST00000279394.3_Splice_Site_p.TASL471del	NM_001252043.1|NM_016151.3	NP_001238972.1|NP_057235.2	Q9UL54	TAOK2_HUMAN	TAO kinase 2	471					actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(3)|skin(1)	22						CACCATCCGAACCGCCTCCCTGGTGAGTGTAGCCA	0.577													44	396	---	---	---	---					
FOXC2	2303	broad.mit.edu	37	16	86601790	86601790	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:86601790delG	ENST00000320354.4	+	1	934	c.849delG	c.(847-849)ccgfs	p.P283fs		NM_005251.2	NP_005242.1	Q99958	FOXC2_HUMAN	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	283					anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|embryonic viscerocranium morphogenesis|insulin receptor signaling pathway|lymphangiogenesis|metanephros development|negative regulation of transcription from RNA polymerase II promoter|neural crest cell fate commitment|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of cell adhesion mediated by integrin|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of vascular wound healing|regulation of blood vessel size|regulation of organ growth|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|ureteric bud development|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	15						CGTCGCCGCCGGGCGGAGAGC	0.786									Late-onset Hereditary Lymphedema				2	4	---	---	---	---					
ENGASE	64772	broad.mit.edu	37	17	77082023	77082040	+	In_Frame_Del	DEL	CGCTGCCAGCCTGCTGGC	CGCTGCCAGCCTGCTGGC	-			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:77082023_77082040delCGCTGCCAGCCTGCTGGC	ENST00000579016.1	+	14	1824_1841	c.1824_1841delCGCTGCCAGCCTGCTGGC	c.(1822-1842)gacgctgccagcctgctggcc>gac	p.AASLLA609del		NM_001042573.2	NP_001036038.1	Q8NFI3	ENASE_HUMAN	endo-beta-N-acetylglucosaminidase	609						cytosol	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity			breast(2)|endometrium(4)|large_intestine(1)|lung(15)|prostate(2)|skin(1)	25						AGGTGGTGGACGCTGCCAGCCTGCTGGCCCCTCTGCCC	0.706													42	73	---	---	---	---					
MBD1	4152	broad.mit.edu	37	18	47800628	47800639	+	In_Frame_Del	DEL	GTCGCAGCAGAA	GTCGCAGCAGAA	-	rs115570375	by1000genomes	TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr18:47800628_47800639delGTCGCAGCAGAA	ENST00000591416.1	-	11	1494_1505	c.1063_1074delTTCTGCTGCGAC	c.(1063-1074)ttctgctgcgacdel	p.FCCD355del	MBD1_ENST00000398493.1_Intron|MBD1_ENST00000382948.5_In_Frame_Del_p.FCCD355del|MBD1_ENST00000590208.1_In_Frame_Del_p.FCCD355del|MBD1_ENST00000398488.1_Intron|MBD1_ENST00000436910.1_In_Frame_Del_p.FCCD332del|MBD1_ENST00000424334.2_In_Frame_Del_p.FCCD406del|MBD1_ENST00000588937.1_In_Frame_Del_p.FCCD332del|MBD1_ENST00000398495.2_Intron|MBD1_ENST00000457839.2_In_Frame_Del_p.FCCD380del|MBD1_ENST00000585595.1_In_Frame_Del_p.FCCD380del|MBD1_ENST00000347968.3_Intron|MBD1_ENST00000339998.6_In_Frame_Del_p.FCCD355del|MBD1_ENST00000269471.5_In_Frame_Del_p.FCCD332del|MBD1_ENST00000587605.1_Intron|MBD1_ENST00000349085.2_Intron|MBD1_ENST00000353909.3_In_Frame_Del_p.FCCD306del|MBD1_ENST00000269468.5_In_Frame_Del_p.FCCD355del|MBD1_ENST00000585672.1_In_Frame_Del_p.FCCD305del|MBD1_ENST00000591535.1_In_Frame_Del_p.FCCD332del			Q9UIS9	MBD1_HUMAN	methyl-CpG binding domain protein 1	355					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|nuclear speck	methyl-CpG binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36						ATTTGGGCTTGTCGCAGCAGAAGTCGCAGCGG	0.651													10	124	---	---	---	---					
RP13-228J13.1	0	broad.mit.edu	37	X	154578865	154578865	+	RNA	DEL	G	G	-	rs150846040	by1000genomes	TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chrX:154578865delG	ENST00000412436.1	-	0	98				RP13-228J13.1_ENST00000444722.1_RNA|RP13-228J13.5_ENST00000453508.1_RNA																							TTTTCTCTCTGTTTTTTTTTT	0.418													2	4	---	---	---	---