Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RFWD3	55159	broad.mit.edu	37	16	74670451	74670451	+	Nonsense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr16:74670451G>A	ENST00000361070.4	-	8	1316	c.1219C>T	c.(1219-1221)Caa>Taa	p.Q407*	RFWD3_ENST00000571750.1_Nonsense_Mutation_p.Q407*	NM_018124.3	NP_060594.3	Q6PCD5	RFWD3_HUMAN	ring finger and WD repeat domain 3	407					DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|response to ionizing radiation	nucleus	MDM2 binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	26						TTCTGACTTTGATGTGACGTA	0.408000													4	23					0	0	1	0	0
CHD2	1106	broad.mit.edu	37	15	93470558	93470558	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr15:93470558G>A	ENST00000394196.4	+	4	1447	c.379G>A	c.(379-381)Gag>Aag	p.E127K	CHD2_ENST00000420239.2_Missense_Mutation_p.E127K|CHD2_ENST00000557381.1_Missense_Mutation_p.E127K|CHD2_ENST00000536619.1_Missense_Mutation_p.E140K	NM_001271.3	NP_001262.3	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	127	Ser-rich.				regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	47	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			TATTAAGGAAGAGGTAAGGAA	0.368000													3	21					0	0	1	0	0
PLEKHA6	22874	broad.mit.edu	37	1	204228438	204228438	+	Missense_Mutation	SNP	G	G	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:204228438G>T	ENST00000272203.3	-	8	1271	c.955C>A	c.(955-957)Cag>Aag	p.Q319K	PLEKHA6_ENST00000414478.1_Missense_Mutation_p.Q339K	NM_014935.4	NP_055750.2	Q9Y2H5	PKHA6_HUMAN	pleckstrin homology domain containing, family A member 6	319	Pro-rich.									breast(2)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(3)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)			ACCCACTGCTGAAGCTGGTTC	0.622000													17	57					7.07596e-05	7.42741e-05	1	1	0
RB1	5925	broad.mit.edu	37	13	49039501	49039501	+	Nonsense_Mutation	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr13:49039501C>G	ENST00000267163.4	+	23	2624	c.2486C>G	c.(2485-2487)tCa>tGa	p.S829*		NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1	829	Domain C; mediates interaction with E4F1.|Interaction with LIMD1.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(11)|p.S829*(2)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ACTCCAAGATCAAGGTGTGTG	0.368000		6	"""D, Mis, N, F, S"""		"""retinoblastoma, sarcoma, breast, small cell lung"""	"""retinoblastoma, sarcoma, breast, small cell lung"""			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			14	38					0	0	1	0	0
ZNF285	26974	broad.mit.edu	37	19	44891631	44891631	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr19:44891631G>C	ENST00000330997.4	-	4	840	c.776C>G	c.(775-777)tCt>tGt	p.S259C	CTC-512J12.6_ENST00000588212.1_Intron|ZNF285_ENST00000591679.1_Missense_Mutation_p.S266C|ZNF285_ENST00000544719.2_Missense_Mutation_p.S259C	NM_152354.3	NP_689567.3			zinc finger protein 285											breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|prostate(5)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	44						ACATTTATAAGATTTTTCTCC	0.418000													22	87					0	0	1	0	0
ELTD1	64123	broad.mit.edu	37	1	79387374	79387374	+	Nonsense_Mutation	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:79387374G>C	ENST00000370742.3	-	9	1244	c.1181C>G	c.(1180-1182)tCa>tGa	p.S394*		NM_022159.3	NP_071442.2	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain containing 1	394	GPS.				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(45)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	69				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		GGTCTCATTTGAGTATGTCAG	0.438000													5	81					0	0	1	0	0
RNF128	79589	broad.mit.edu	37	X	105937235	105937235	+	Translation_Start_Site	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chrX:105937235G>A	ENST00000324342.3	+	1	168	c.3G>A	c.(1-3)atG>atA	p.M1I		NM_024539.3	NP_078815.3	Q8TEB7	RN128_HUMAN	ring finger protein 128, E3 ubiquitin protein ligase	0						endomembrane system|integral to membrane|perinuclear region of cytoplasm	zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(6)|ovary(1)	11						AATGAGCAATGAACCAGGAGA	0.353000													6	15					0	0	1	0	0
ZNF836	162962	broad.mit.edu	37	19	52659999	52659999	+	Nonsense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr19:52659999G>A	ENST00000322146.8	-	5	1458	c.937C>T	c.(937-939)Caa>Taa	p.Q313*	ZNF836_ENST00000597252.1_Nonsense_Mutation_p.Q313*|CTC-471J1.8_ENST00000594362.1_RNA	NM_001102657.1	NP_001096127.1	Q6ZNA1	ZN836_HUMAN	zinc finger protein 836	313					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(9)|lung(10)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26						TTATAACTTTGACTAAAGGAC	0.398000													6	52					0	0	1	0	0
MINK1	50488	broad.mit.edu	37	17	4788879	4788879	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr17:4788879G>A	ENST00000355280.6	+	7	806	c.610G>A	c.(610-612)Gag>Aag	p.E204K	MINK1_ENST00000453408.3_Missense_Mutation_p.E204K|MINK1_ENST00000347992.7_Missense_Mutation_p.E204K	NM_001024937.3|NM_015716.4|NM_153827.4	NP_001020108.1|NP_056531.1|NP_722549.2	Q8N4C8	MINK1_HUMAN	misshapen-like kinase 1	204	Protein kinase.				JNK cascade	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)|stomach(1)	6						CGCCTGTGATGAGAACCCTGA	0.582000													13	38					0	0	1	0	0
LY86-AS1	285780	broad.mit.edu	37	6	6347533	6347533	+	RNA	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr6:6347533G>A	ENST00000429345.1	-	0	1105					NR_026970.1																						ACCTTGATGTGATTCAGCAGG	0.537000													3	7					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152285339	152285339	+	Missense_Mutation	SNP	C	C	G	rs140188504		TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:152285339C>G	ENST00000368799.1	-	3	2058	c.2023G>C	c.(2023-2025)Gac>Cac	p.D675H	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	675	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGGAGCTGTCTGCAGAGTGC	0.527000									Ichthyosis				96	320					0	0	1	0	0
OR8J3	81168	broad.mit.edu	37	11	55905037	55905037	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr11:55905037G>C	ENST00000301529.1	-	1	157	c.158C>G	c.(157-159)tCt>tGt	p.S53C		NM_001004064.1	NP_001004064.1	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J, member 3	53					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(38)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	59	Esophageal squamous(21;0.00693)					TTGAAGTCGAGAGTCAACACT	0.473000													9	96					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7572193	7572193	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr6:7572193G>C	ENST00000379802.3	+	15	2363	c.2022G>C	c.(2020-2022)aaG>aaC	p.K674N	DSP_ENST00000418664.2_Missense_Mutation_p.K674N	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	674	Globular 1.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AGCTGCAGAAGATTCGCAGGC	0.453000													14	54					0	0	1	0	0
XRN1	54464	broad.mit.edu	37	3	142141571	142141571	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr3:142141571C>T	ENST00000264951.4	-	8	937	c.820G>A	c.(820-822)Gat>Aat	p.D274N	XRN1_ENST00000544157.1_Missense_Mutation_p.D64N|XRN1_ENST00000463916.1_Missense_Mutation_p.D274N|XRN1_ENST00000392981.2_Missense_Mutation_p.D274N	NM_019001.3	NP_061874.3	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1	274					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			NS(1)|breast(3)|endometrium(6)|kidney(12)|large_intestine(11)|liver(1)|lung(17)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	61						CTTTCAATATCATATTTAAAT	0.308000													9	59					0	0	1	0	0
CCDC135	84229	broad.mit.edu	37	16	57736040	57736040	+	Nonsense_Mutation	SNP	G	G	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr16:57736040G>T	ENST00000360716.3	+	6	918	c.697G>T	c.(697-699)Gag>Tag	p.E233*	CCDC135_ENST00000394337.4_Nonsense_Mutation_p.E233*|CCDC135_ENST00000336825.8_Intron			Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	233						cytoplasm				breast(1)|central_nervous_system(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30						GAAGCCCAAGGAGGTATGGTC	0.602000													5	25					8.12818e-05	8.50374e-05	1	1	0
OR2T10	127069	broad.mit.edu	37	1	248756566	248756566	+	Silent	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:248756566G>A	ENST00000330500.2	-	1	534	c.504C>T	c.(502-504)ttC>ttT	p.F168F		NM_001004693.1	NP_001004693.1	Q8NGZ9	O2T10_HUMAN	olfactory receptor, family 2, subfamily T, member 10	168					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(17)|skin(3)|upper_aerodigestive_tract(1)	26	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GGGATCTGCAGAAGGGGAAGC	0.502000													26	56					0	0	1	0	0
NCAM2	4685	broad.mit.edu	37	21	22782762	22782762	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr21:22782762G>A	ENST00000400546.1	+	10	1613	c.1364G>A	c.(1363-1365)gGa>gAa	p.G455E	NCAM2_ENST00000284894.7_Missense_Mutation_p.G313E	NM_004540.3	NP_004531.2	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2	455	Ig-like C2-type 5.				neuron cell-cell adhesion	integral to membrane|plasma membrane				breast(4)|cervix(2)|endometrium(8)|kidney(6)|large_intestine(22)|liver(4)|lung(49)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	108		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		TATAGTACAGGAAGAAAGATG	0.294000													6	55					0	0	1	0	0
SPNS3	201305	broad.mit.edu	37	17	4389823	4389823	+	Silent	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr17:4389823G>C	ENST00000355530.2	+	11	1675	c.1395G>C	c.(1393-1395)ctG>ctC	p.L465L	SPNS3_ENST00000333476.2_Silent_p.L338L	NM_182538.4	NP_872344.3	Q6ZMD2	SPNS3_HUMAN	spinster homolog 3 (Drosophila)	465					lipid transport|transmembrane transport	integral to membrane				NS(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|skin(6)|stomach(2)	28						GCTGCTTCCTGCTGACTGCGC	0.677000													4	44					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53856702	53856702	+	Missense_Mutation	SNP	G	G	A	rs150688663	by1000genomes	TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr19:53856702G>A	ENST00000458035.1	+	4	2891	c.2774G>A	c.(2773-2775)cGt>cAt	p.R925H	ZNF845_ENST00000595091.1_Missense_Mutation_p.R925H	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	925					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R925H(3)		endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						AAAACCTTCCGTCACAATTCA	0.363000													3	32					0	0	1	0	0
HLA-C	3107	broad.mit.edu	37	6	31239616	31239616	+	Missense_Mutation	SNP	C	C	A	rs150810080	byFrequency	TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr6:31239616C>A	ENST00000383329.3	-	2	117	c.103G>T	c.(103-105)Gcc>Tcc	p.A35S	HLA-C_ENST00000376228.5_Missense_Mutation_p.A35S			Q9TNN7	1C05_HUMAN	major histocompatibility complex, class I, C	35	Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex				central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(4)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	17						CGGGACACGGCGGTGTCGAAA	0.721000													3	20					1	1	1	1	0
C9orf156	51531	broad.mit.edu	37	9	100667059	100667059	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr9:100667059G>A	ENST00000375119.3	-	5	1358	c.1282C>T	c.(1282-1284)Cat>Tat	p.H428Y		NM_016481.3	NP_057565.3	Q9BU70	NAP1_HUMAN	chromosome 9 open reading frame 156	428					interspecies interaction between organisms		hydrolase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(3)|prostate(1)|skin(1)	13		Acute lymphoblastic leukemia(62;0.158)				CCAGTCATATGAACAGGCTCA	0.502000													14	60					0	0	1	0	0
MAP3K19	80122	broad.mit.edu	37	2	135757558	135757558	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr2:135757558C>T	ENST00000375845.3	-	4	293	c.263G>A	c.(262-264)aGa>aAa	p.R88K	MAP3K19_ENST00000315513.3_5'UTR|MAP3K19_ENST00000392918.3_Missense_Mutation_p.R88K|MAP3K19_ENST00000392915.1_Missense_Mutation_p.R105K|MAP3K19_ENST00000375844.3_Missense_Mutation_p.R88K|MAP3K19_ENST00000392917.3_Missense_Mutation_p.R88K|MAP3K19_ENST00000358371.4_Intron	NM_001018044.2|NM_025052.3	NP_001018054.1|NP_079328.3			mitogen-activated protein kinase kinase kinase 19																		ACTGACATCTCTTGGAAAAGT	0.373000													5	68					0	0	1	0	0
THUMPD3	25917	broad.mit.edu	37	3	9426371	9426371	+	Silent	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr3:9426371G>A	ENST00000345094.3	+	10	1857	c.1523G>A	c.(1522-1524)tGa>tAa	p.*508*	THUMPD3_ENST00000452837.2_Silent_p.*508*|THUMPD3_ENST00000515662.2_Silent_p.*508*|SETD5-AS1_ENST00000468186.1_RNA	NM_001114092.1|NM_015453.2	NP_001107564.1|NP_056268.2	Q9BV44	THUM3_HUMAN	THUMP domain containing 3	0							methyltransferase activity|protein binding|RNA binding			NS(1)|central_nervous_system(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	19	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.101)		TGCAAAGAATGAAGATGACTA	0.398000													19	75					0	0	1	0	0
TECRL	253017	broad.mit.edu	37	4	65188509	65188509	+	Splice_Site	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr4:65188509G>A	ENST00000381210.3	-	4	443	c.333C>T	c.(331-333)ggC>ggT	p.G111G	TECRL_ENST00000507440.1_Splice_Site_p.G111G	NM_001010874.4	NP_001010874.2	Q5HYJ1	TECRL_HUMAN	trans-2,3-enoyl-CoA reductase-like	111					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors			endometrium(2)|kidney(5)|large_intestine(7)|lung(30)|prostate(1)|skin(1)|stomach(1)	47						AAAAAGGCCCGCCtaaaataa	0.318000													11	63					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62286724	62286724	+	Silent	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr11:62286724G>C	ENST00000378024.4	-	5	15439	c.15165C>G	c.(15163-15165)ctC>ctG	p.L5055L	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	5055					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				CCGGAGCCTTGAGGCTGGCAT	0.443000													34	235					0	0	1	0	0
USP4	7375	broad.mit.edu	37	3	49339822	49339822	+	Missense_Mutation	SNP	C	C	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr3:49339822C>A	ENST00000351842.4	-	9	1149	c.1141G>T	c.(1141-1143)Gat>Tat	p.D381Y	USP4_ENST00000265560.4_Missense_Mutation_p.D428Y|USP4_ENST00000488520.1_5'UTR	NM_199443.2	NP_955475.1	Q13107	UBP4_HUMAN	ubiquitin specific peptidase 4 (proto-oncogene)	428					negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|liver(1)|lung(10)|ovary(3)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		CATACCGCATCTGGCCGCCCA	0.468000													17	83					1.99824e-07	2.15456e-07	1	1	0
CEP350	9857	broad.mit.edu	37	1	180063698	180063698	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:180063698G>A	ENST00000367607.3	+	34	8876	c.8458G>A	c.(8458-8460)Gaa>Aaa	p.E2820K	CEP350_ENST00000490141.1_3'UTR	NM_014810.4	NP_055625.4	Q5VT06	CE350_HUMAN	centrosomal protein 350kDa	2820						centrosome|nucleus|spindle				central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	66						CTTAAGTTCTGAATTGGAAGA	0.403000													5	33					0	0	1	0	0
RAB11FIP5	26056	broad.mit.edu	37	2	73315528	73315528	+	Silent	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr2:73315528C>G	ENST00000258098.6	-	3	1458	c.1218G>C	c.(1216-1218)ctG>ctC	p.L406L	RAB11FIP5_ENST00000493523.2_5'UTR	NM_015470.2	NP_056285.1	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	406					protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding	p.L406L(1)		biliary_tract(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(9)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	23						CCTGAGCACTCAGCTCCTCCT	0.657000													12	61					0	0	1	0	0
AGAP7	653268	broad.mit.edu	37	10	51465271	51465271	+	Silent	SNP	G	G	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr10:51465271G>T	ENST00000374095.5	-	7	1310	c.1185C>A	c.(1183-1185)ggC>ggA	p.G395G		NM_001077685.1	NP_001071153.1	Q5VUJ5	AGAP7_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 7	395	PH.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			kidney(1)|large_intestine(1)|lung(7)|ovary(1)|skin(1)	11						GCCACGTTTGGCCAGTGGCAG	0.532000													12	75					6.40141e-05	6.74169e-05	1	1	0
HSPA1A	3303	broad.mit.edu	37	6	31785264	31785264	+	Silent	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr6:31785264C>T	ENST00000375651.5	+	1	1974	c.1731C>T	c.(1729-1731)gtC>gtT	p.V577V	HSPA1A_ENST00000608703.1_Silent_p.V412V|HSPA1A_ENST00000458062.2_Silent_p.V486V	NM_005345.5	NP_005336.3	P08107	HSP71_HUMAN	heat shock 70kDa protein 1A	577					anti-apoptosis|mRNA catabolic process|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of inclusion body assembly|protein refolding|response to unfolded protein	cytosol|endoplasmic reticulum|inclusion body|mitochondrion|nuclear speck|perinuclear region of cytoplasm|ribonucleoprotein complex	ATP binding|protein binding involved in protein folding|protein N-terminus binding|receptor activity|ubiquitin protein ligase binding|unfolded protein binding			endometrium(1)|ovary(1)|stomach(1)	3						GTCAAGAGGTCATCTCGTGGC	0.572000													9	33					0	0	1	0	0
VAMP2	6844	broad.mit.edu	37	17	8064983	8064983	+	Silent	SNP	G	G	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr17:8064983G>T	ENST00000316509.6	-	3	320	c.225C>A	c.(223-225)tcC>tcA	p.S75S	VAMP2_ENST00000488857.1_Silent_p.S77S|VAMP2_ENST00000481878.1_Silent_p.S75S|RP11-599B13.6_ENST00000498285.1_Silent_p.S75S|VAMP2_ENST00000404970.3_Silent_p.S30S	NM_014232.2	NP_055047.2	P63027	VAMP2_HUMAN	vesicle-associated membrane protein 2 (synaptobrevin 2)	75	v-SNARE coiled-coil homology.				energy reserve metabolic process|glutamate secretion|post-Golgi vesicle-mediated transport|regulation of insulin secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to plasma membrane|synaptic vesicle membrane|synaptosome										Botulinum Toxin Type B(DB00042)	TTTCAAACTGGGAGGCCCCCG	0.582000													21	48					7.41877e-09	8.10949e-09	1	1	0
UGT1A1	54658	broad.mit.edu	37	2	234526524	234526524	+	Silent	SNP	A	A	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr2:234526524A>T	ENST00000373450.4	+	1	234	c.171A>T	c.(169-171)gtA>gtT	p.V57V		NM_019076.4	NP_061949.3	P22309	UD11_HUMAN							bilirubin conjugation|digestion|estrogen metabolic process|flavone metabolic process|heme catabolic process	endoplasmic reticulum membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding|steroid binding			breast(1)|central_nervous_system(2)|endometrium(7)|large_intestine(5)|lung(9)|skin(4)|urinary_tract(2)	30		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;4.1e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000435)|Lung(119;0.00211)|LUSC - Lung squamous cell carcinoma(224;0.0054)	Abacavir(DB01048)|Adenine(DB00173)|Diclofenac(DB00586)|Estradiol(DB00783)|Ezetimibe(DB00973)|Irinotecan(DB00762)|Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|Propofol(DB00818)|Rifampin(DB01045)|Troglitazone(DB00197)	AGGTGGTTGTAGTCATGCCAG	0.522000													5	73					0	0	1	0	0
IPO7	10527	broad.mit.edu	37	11	9463660	9463660	+	Missense_Mutation	SNP	G	G	T	rs145780187	byFrequency	TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr11:9463660G>T	ENST00000379719.3	+	24	3077	c.2935G>T	c.(2935-2937)Gca>Tca	p.A979S		NM_006391.2	NP_006382.1	O95373	IPO7_HUMAN	importin 7	979					interspecies interaction between organisms|signal transduction	Golgi apparatus|nuclear pore|soluble fraction	protein transporter activity|Ran GTPase binding|small GTPase regulator activity			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				all cancers(16;8.29e-09)|Epithelial(150;4.76e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0217)		GTGGTATCAGGCACTGACTCA	0.388000													5	59					1	1	1	1	0
SPTBN4	57731	broad.mit.edu	37	19	41038642	41038642	+	Silent	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr19:41038642G>A	ENST00000352632.3	+	19	4145	c.4059G>A	c.(4057-4059)ctG>ctA	p.L1353L	SPTBN4_ENST00000598249.1_Silent_p.L1353L|SPTBN4_ENST00000595535.1_Silent_p.L1353L|SPTBN4_ENST00000392025.1_Silent_p.L96L|SPTBN4_ENST00000392023.1_Silent_p.L29L|SPTBN4_ENST00000338932.3_Silent_p.L1353L			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	1353					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TGGCCGAGCTGGCTCAGAATA	0.617000													6	24					0	0	1	0	0
KIAA0930	23313	broad.mit.edu	37	22	45595791	45595791	+	Silent	SNP	G	G	A	rs150877720		TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr22:45595791G>A	ENST00000336156.5	-	8	1043	c.978C>T	c.(976-978)aaC>aaT	p.N326N	KIAA0930_ENST00000443310.3_Silent_p.N308N|KIAA0930_ENST00000391627.2_Silent_p.N292N|KIAA0930_ENST00000251993.7_Silent_p.N331N|KIAA0930_ENST00000474515.1_5'UTR	NM_001009880.1	NP_001009880.1	Q6ICG6	K0930_HUMAN	KIAA0930								protein binding	p.N331N(1)		endometrium(1)|kidney(4)|large_intestine(2)|lung(7)|urinary_tract(1)	15						CCTCGCTGTCGTTGGCCGAGT	0.627000													18	42					0	0	1	0	0
LOC728715	728715	broad.mit.edu	37	12	9711779	9711779	+	RNA	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr12:9711779C>G	ENST00000520314.1	+	0	360																											AGGGGATATTCTAGGACTTGC	0.403000													5	13					0	0	1	0	0
CCNH	902	broad.mit.edu	37	5	86690883	86690883	+	Nonsense_Mutation	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr5:86690883G>C	ENST00000508855.1	-	7	741	c.689C>G	c.(688-690)tCa>tGa	p.S230*	CCNH_ENST00000256897.4_Nonsense_Mutation_p.S304*|CCNH_ENST00000504878.1_Nonsense_Mutation_p.S230*			P51946	CCNH_HUMAN	cyclin H	304					G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	cyclin-dependent protein kinase activating kinase holoenzyme complex|holo TFIIH complex	protein kinase binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|liver(1)|lung(2)|ovary(2)	15		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;9.01e-39)|Epithelial(54;5.08e-33)|all cancers(79;4.28e-28)		GGATTTCTTTGAGACGTAATC	0.318000								Direct reversal of damage;Direct reversal of damage;Nucleotide excision repair (NER)					8	106					0	0	1	0	0
ABCB1	5243	broad.mit.edu	37	7	87173537	87173537	+	Nonsense_Mutation	SNP	C	C	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr7:87173537C>A	ENST00000265724.3	-	18	2536	c.2119G>T	c.(2119-2121)Gaa>Taa	p.E707*	ABCB1_ENST00000543898.1_Nonsense_Mutation_p.E643*	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	707					G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	TAAGGCCATTCAGTTAAATTT	0.323000													12	100					4.3838e-07	4.69481e-07	1	1	0
SIGLEC10	89790	broad.mit.edu	37	19	51918853	51918853	+	Silent	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr19:51918853C>T	ENST00000353836.5	-	6	1262	c.1041G>A	c.(1039-1041)ctG>ctA	p.L347L	SIGLEC10_ENST00000442846.3_Silent_p.L199L|SIGLEC10_ENST00000525998.1_Silent_p.L257L|SIGLEC10_ENST00000439889.2_Silent_p.L289L|SIGLEC10_ENST00000441969.3_Silent_p.L289L|SIGLEC10_ENST00000436984.2_Silent_p.L299L|SIGLEC10_ENST00000356298.5_Silent_p.L347L|SIGLEC10_ENST00000432469.2_Silent_p.L264L|SIGLEC10_ENST00000339313.5_Silent_p.L347L	NM_001171157.1|NM_001171158.1|NM_001171159.1	NP_001164628.1|NP_001164629.1|NP_001164630.1	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10	347	Ig-like C2-type 3.				cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(27)|ovary(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		CCATCACTCTCAGGTTCTCTG	0.592000													7	152					0	0	1	0	0
FANCC	2176	broad.mit.edu	37	9	97912337	97912337	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr9:97912337C>T	ENST00000289081.3	-	7	808	c.554G>A	c.(553-555)cGa>cAa	p.R185Q	FANCC_ENST00000375305.1_Missense_Mutation_p.R185Q	NM_000136.2	NP_000127.2	Q00597	FANCC_HUMAN	Fanconi anemia, complementation group C	185					protein complex assembly	cytosol|nucleoplasm	protein binding			kidney(1)|skin(1)|upper_aerodigestive_tract(1)	3		Acute lymphoblastic leukemia(62;0.138)				GACACAAACTCGTGACAGGGA	0.473000			"""D, Mis, N, F, S"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				8	24					0	0	1	0	0
USP32	84669	broad.mit.edu	37	17	58422964	58422964	+	Missense_Mutation	SNP	C	C	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr17:58422964C>A	ENST00000300896.4	-	2	258	c.64G>T	c.(64-66)Gat>Tat	p.D22Y	USP32_ENST00000393003.3_Missense_Mutation_p.D22Y	NM_032582.3	NP_115971.2	Q8NFA0	UBP32_HUMAN	ubiquitin specific peptidase 32	22					protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(5)|endometrium(5)|kidney(4)|large_intestine(12)|liver(1)|lung(24)|pancreas(1)|prostate(3)|skin(3)|urinary_tract(1)	62	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			AGCTCTACATCTGTAACTGCA	0.438000													11	114					0.000151284	0.000157754	1	1	0
NID1	4811	broad.mit.edu	37	1	236180546	236180546	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:236180546G>A	ENST00000264187.6	-	10	2238	c.2156C>T	c.(2155-2157)tCa>tTa	p.S719L	NID1_ENST00000366595.3_Intron	NM_002508.2	NP_002499.2	P14543	NID1_HUMAN	nidogen 1	719	EGF-like 3; calcium-binding (Potential).				cell-matrix adhesion	basement membrane	calcium ion binding			breast(4)|endometrium(9)|kidney(1)|large_intestine(23)|lung(20)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(1)	66	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	CCCACACACTGAGGGTTGTTC	0.413000													25	79					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168105419	168105419	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr2:168105419G>A	ENST00000409195.1	+	9	7606	c.7517G>A	c.(7516-7518)gGa>gAa	p.G2506E	XIRP2_ENST00000295237.9_Missense_Mutation_p.G2506E|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.G2284E|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409043.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	2331					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						ACAGTTCCAGGAACTTCAGCA	0.378000													7	62					0	0	1	0	0
PEX19	5824	broad.mit.edu	37	1	160249910	160249910	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:160249910C>T	ENST00000368072.5	-	6	742	c.721G>A	c.(721-723)Gaa>Aaa	p.E241K	PEX19_ENST00000440949.3_Missense_Mutation_p.E151K|PEX19_ENST00000532508.1_5'UTR|DCAF8_ENST00000608310.1_Missense_Mutation_p.E94K|DCAF8_ENST00000556710.1_Missense_Mutation_p.E94K	NM_001193644.1|NM_002857.3	NP_001180573.1|NP_002848.1			peroxisomal biogenesis factor 19											cervix(1)|endometrium(2)|large_intestine(2)|lung(4)|prostate(2)	11	all_cancers(52;1.27e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TGAGTGGTTTCACTGTCTGTG	0.498000													24	458					0	0	1	0	0
TNPO1	3842	broad.mit.edu	37	5	72151732	72151732	+	Silent	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr5:72151732C>T	ENST00000337273.5	+	4	763	c.337C>T	c.(337-339)Ctg>Ttg	p.L113L	TNPO1_ENST00000454282.1_Intron|TNPO1_ENST00000506351.2_Silent_p.L105L|TNPO1_ENST00000513944.1_3'UTR|TNPO1_ENST00000447967.2_Silent_p.L105L|TNPO1_ENST00000523768.1_Intron	NM_002270.3	NP_002261.3	Q92973	TNPO1_HUMAN	transportin 1	113					interspecies interaction between organisms|mRNA metabolic process|protein import into nucleus, translocation	cytosol|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(10)|lung(6)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	36		Lung NSC(167;0.0053)|Ovarian(174;0.0175)		OV - Ovarian serous cystadenocarcinoma(47;6.14e-54)		CTCCTCTCCTCTGATTAGAGC	0.328000													4	31					0	0	1	0	0
MARCH10	162333	broad.mit.edu	37	17	60802301	60802301	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr17:60802301G>A	ENST00000544856.2	-	8	2477	c.2099C>T	c.(2098-2100)tCa>tTa	p.S700L	RP11-156L14.1_ENST00000582564.1_RNA|RP11-156L14.1_ENST00000584597.1_RNA|MARCH10_ENST00000456609.2_Missense_Mutation_p.S701L|MARCH10_ENST00000583600.1_Missense_Mutation_p.S739L|RP11-156L14.1_ENST00000577270.1_RNA|MARCH10_ENST00000311269.5_Missense_Mutation_p.S701L|RP11-156L14.1_ENST00000579201.1_RNA			Q8NA82	MARHA_HUMAN	membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase	701							ligase activity|zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|liver(1)|lung(15)	38						CCACCTACCTGATGTTATTTT	0.542000													14	220					0	0	1	0	0
AMZ2	51321	broad.mit.edu	37	17	66251937	66251937	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr17:66251937C>T	ENST00000359904.3	+	6	1979	c.847C>T	c.(847-849)Cgg>Tgg	p.R283W	AMZ2_ENST00000577985.1_Missense_Mutation_p.R283W|AMZ2_ENST00000585050.1_Intron|AMZ2_ENST00000580753.1_Missense_Mutation_p.R283W|AMZ2_ENST00000577866.1_Missense_Mutation_p.R283W|AMZ2_ENST00000392720.2_Missense_Mutation_p.R283W|AMZ2_ENST00000577273.1_Intron|AMZ2_ENST00000359783.4_Missense_Mutation_p.R225W	NM_016627.4	NP_057711.3	Q86W34	AMZ2_HUMAN	archaelysin family metallopeptidase 2	283							metallopeptidase activity|zinc ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)	9	all_cancers(12;1.12e-09)		BRCA - Breast invasive adenocarcinoma(8;3.17e-08)|LUSC - Lung squamous cell carcinoma(166;0.24)			AGAAGCTGACCGGCGCCCTCT	0.507000													11	74					0	0	1	0	0
GLTSCR1L	23506	broad.mit.edu	37	6	42832396	42832396	+	Splice_Site	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr6:42832396G>A	ENST00000314073.5	+	13	2628		c.e13-1		GLTSCR1L_ENST00000394168.1_Splice_Site					GLTSCR1-like																		CCCATTTCCAGAGGGTTTTCA	0.483000													10	35					0	0	1	0	0
ZNF160	90338	broad.mit.edu	37	19	53576752	53576752	+	Missense_Mutation	SNP	C	C	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr19:53576752C>A	ENST00000355147.5	-	7	690	c.282G>T	c.(280-282)agG>agT	p.R94S	ZNF160_ENST00000418871.1_Intron|ZNF160_ENST00000599056.1_Intron|ZNF160_ENST00000429604.1_Intron|ZNF160_ENST00000601421.1_Intron			Q9HCG1	ZN160_HUMAN	zinc finger protein 160	0					hemopoiesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(8)|lung(10)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	35				GBM - Glioblastoma multiforme(134;0.02)		GTTTCCATCTCCTGAGCAGGT	0.557000													6	22					0.00116845	0.00120651	1	1	0
ABHD12	26090	broad.mit.edu	37	20	25282958	25282958	+	Nonsense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr20:25282958G>A	ENST00000339157.5	-	12	1326	c.1054C>T	c.(1054-1056)Cga>Tga	p.R352*	ABHD12_ENST00000376542.3_Nonsense_Mutation_p.R352*	NM_001042472.2	NP_001035937.1	Q8N2K0	ABD12_HUMAN	abhydrolase domain containing 12	352						integral to membrane	acylglycerol lipase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|liver(1)|lung(1)|skin(1)|urinary_tract(1)	12						CGGAAGCTTCGAGCTGGTGCG	0.557000													13	52					0	0	1	0	0
SLC35F3	148641	broad.mit.edu	37	1	234445046	234445046	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:234445046G>A	ENST00000366618.3	+	4	953	c.808G>A	c.(808-810)Gac>Aac	p.D270N	SLC35F3_ENST00000366617.3_Missense_Mutation_p.D201N	NM_173508.2	NP_775779.1	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	201					transport	integral to membrane				breast(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|urinary_tract(1)	32	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			CGTTCTCAGGGACAGATTCAT	0.448000													5	78					0	0	1	0	0
ESPL1	9700	broad.mit.edu	37	12	53663020	53663020	+	Missense_Mutation	SNP	A	A	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr12:53663020A>C	ENST00000257934.4	+	3	385	c.294A>C	c.(292-294)gaA>gaC	p.E98D	ESPL1_ENST00000552462.1_Missense_Mutation_p.E98D	NM_012291.4	NP_036423.4	Q14674	ESPL1_HUMAN	extra spindle pole bodies homolog 1 (S. cerevisiae)	98					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(10)|large_intestine(12)|lung(21)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(8)	70						TCTACCTGGAACGAATTCTCT	0.592000													17	62					0	0	1	0	0
ZNF616	90317	broad.mit.edu	37	19	52619320	52619320	+	Nonsense_Mutation	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr19:52619320G>C	ENST00000600228.1	-	4	1358	c.1097C>G	c.(1096-1098)tCa>tGa	p.S366*	ZNF616_ENST00000330123.5_3'UTR	NM_178523.3	NP_848618.2	Q08AN1	ZN616_HUMAN	zinc finger protein 616	366					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(14)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	48				GBM - Glioblastoma multiforme(134;0.00392)|OV - Ovarian serous cystadenocarcinoma(262;0.0189)		TACAAGATTTGATCTATGTCT	0.408000													16	159					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78262066	78262066	+	Silent	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr17:78262066C>T	ENST00000582970.1	+	4	857	c.714C>T	c.(712-714)gcC>gcT	p.A238A	RNF213_ENST00000319921.4_Silent_p.A238A|RNF213_ENST00000456466.1_Silent_p.A238A|RNF213_ENST00000508628.2_Silent_p.A287A	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	238										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			AAGATGCTGCCCAGGAGCTCC	0.632000													7	51					0	0	1	0	0
SLX4	84464	broad.mit.edu	37	16	3640578	3640578	+	Missense_Mutation	SNP	G	G	A	rs138344471		TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr16:3640578G>A	ENST00000294008.3	-	12	3701	c.3061C>T	c.(3061-3063)Cgc>Tgc	p.R1021C		NM_032444.2	NP_115820.2	Q8IY92	SLX4_HUMAN	SLX4 structure-specific endonuclease subunit	1021	Interaction with PLK1 and TERF2-TERF2IP.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding			breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	76						GGAGCCAGGCGATGAGAAACC	0.622000								Direct reversal of damage					5	51					0	0	1	0	0
TGM5	9333	broad.mit.edu	37	15	43527103	43527103	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr15:43527103G>C	ENST00000220420.5	-	11	1746	c.1739C>G	c.(1738-1740)tCc>tGc	p.S580C	TGM5_ENST00000349114.4_Missense_Mutation_p.S498C	NM_201631.3	NP_963925.2	O43548	TGM5_HUMAN	transglutaminase 5	580					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(11)|lung(15)|skin(6)|urinary_tract(1)	44		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	CTGGGAATAGGAGATTTTGCA	0.498000													16	36					0	0	1	0	0
KDSR	2531	broad.mit.edu	37	18	61030057	61030057	+	Silent	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr18:61030057C>T	ENST00000406396.3	-	2	544	c.153G>A	c.(151-153)gaG>gaA	p.E51E	KDSR_ENST00000326575.5_Silent_p.E51E	NM_002035.2	NP_002026.1	Q06136	KDSR_HUMAN	3-ketodihydrosphingosine reductase	51					3-keto-sphinganine metabolic process	endoplasmic reticulum membrane|extracellular space|integral to membrane	3-dehydrosphinganine reductase activity|binding			endometrium(2)|large_intestine(2)|lung(3)|skin(1)|stomach(1)	9						GTTTATAGCACTCGATAGCAA	0.393000													9	39					0	0	1	0	0
ZCCHC11	23318	broad.mit.edu	37	1	52896986	52896986	+	Silent	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:52896986G>C	ENST00000371544.3	-	28	4669	c.4407C>G	c.(4405-4407)gtC>gtG	p.V1469V	ZCCHC11_ENST00000257177.4_Silent_p.V1470V	NM_001009881.2|NM_015269.2	NP_001009881.1|NP_056084.1	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11	1469	Gln-rich.|Pro-rich.				miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			NS(2)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(17)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	58						GTGGCATCTGGACCTGATGGG	0.547000													27	65					0	0	1	0	0
OR10K1	391109	broad.mit.edu	37	1	158436256	158436256	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:158436256G>A	ENST00000289451.2	+	1	985	c.905G>A	c.(904-906)cGa>cAa	p.R302Q		NM_001004473.1	NP_001004473.1	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K, member 1	302					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	27	all_hematologic(112;0.0378)					TCAGCCCTACGAAGAACAATC	0.373000													38	112					0	0	1	0	0
TOR1AIP1	26092	broad.mit.edu	37	1	179853832	179853832	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:179853832G>A	ENST00000606911.2	+	2	672	c.481G>A	c.(481-483)Gaa>Aaa	p.E161K	TOR1AIP1_ENST00000528443.2_Missense_Mutation_p.E161K|TOR1AIP1_ENST00000271583.3_Missense_Mutation_p.E161K|TOR1AIP1_ENST00000474875.1_3'UTR|TOR1AIP1_ENST00000435319.4_Missense_Mutation_p.E40K			Q5JTV8	TOIP1_HUMAN	torsin A interacting protein 1							integral to membrane|nuclear inner membrane				breast(4)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(4)|ovary(2)|skin(1)|urinary_tract(1)	18						TTTAGAGGATGAAGCATCTTC	0.343000													7	50					0	0	1	0	0
MST1L	11223	broad.mit.edu	37	1	17083671	17083671	+	RNA	SNP	C	C	G	rs1057420	by1000genomes	TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:17083671C>G	ENST00000455405.2	-	0	917																											aagtcttGTCCTTGACTGTAC	0.403000													5	28					0	0	1	0	0
OR2T10	127069	broad.mit.edu	37	1	248756794	248756794	+	Silent	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:248756794G>A	ENST00000330500.2	-	1	306	c.276C>T	c.(274-276)atC>atT	p.I92I		NM_001004693.1	NP_001004693.1	Q8NGZ9	O2T10_HUMAN	olfactory receptor, family 2, subfamily T, member 10	92					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(17)|skin(3)|upper_aerodigestive_tract(1)	26	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CAAGGACCGAGATGGTCTTGT	0.502000													8	21					0	0	1	0	0
SLC5A7	60482	broad.mit.edu	37	2	108604668	108604668	+	Silent	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr2:108604668G>A	ENST00000264047.2	+	2	333	c.57G>A	c.(55-57)ttG>ttA	p.L19L	SLC5A7_ENST00000540517.1_Intron|SLC5A7_ENST00000409059.1_Silent_p.L19L	NM_021815.2	NP_068587.1	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (sodium/choline cotransporter), member 7	19					acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(23)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	49					Choline(DB00122)	TTCTAATTTTGCTGGTTGGAA	0.453000													5	62					0	0	1	0	0
TLR10	81793	broad.mit.edu	37	4	38775501	38775501	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr4:38775501C>T	ENST00000308973.4	-	4	2316	c.1711G>A	c.(1711-1713)Gaa>Aaa	p.E571K	TLR10_ENST00000508334.1_Missense_Mutation_p.E571K|TLR10_ENST00000506111.1_Missense_Mutation_p.E571K|TLR10_ENST00000361424.2_Missense_Mutation_p.E571K	NM_001017388.2|NM_001195107.1|NM_030956.3	NP_001017388.1|NP_001182036.1|NP_112218.2	Q9BXR5	TLR10_HUMAN	toll-like receptor 10	571	LRRCT.				inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane	transmembrane receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(2)	25						CAAGATAATTCGTGGAGATGA	0.438000													13	84					0	0	1	0	0
ZNF74	7625	broad.mit.edu	37	22	20760739	20760739	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr22:20760739C>G	ENST00000400451.2	+	5	1930	c.1416C>G	c.(1414-1416)ttC>ttG	p.F472L	ZNF74_ENST00000357502.5_3'UTR|ZNF74_ENST00000403682.3_3'UTR|ZNF74_ENST00000405993.1_Missense_Mutation_p.F440L|ZNF74_ENST00000356671.5_Missense_Mutation_p.F472L	NM_003426.3	NP_003417.2	Q16587	ZNF74_HUMAN	zinc finger protein 74	472					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|nucleus	DNA binding|RNA binding|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	19	Melanoma(16;0.000465)|Ovarian(15;0.0025)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)|all_lung(157;0.248)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			AGAAGCCCTTCAAGTGCAACG	0.647000													17	51					0	0	1	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128844362	128844362	+	Silent	SNP	T	T	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr11:128844362T>C	ENST00000310343.9	-	20	2687	c.2688A>G	c.(2686-2688)ggA>ggG	p.G896G	ARHGAP32_ENST00000527272.1_Silent_p.G547G|ARHGAP32_ENST00000524655.1_Silent_p.G822G|ARHGAP32_ENST00000392657.3_Silent_p.G547G	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	896					cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						TTAATTTCCGTCCTATCTTCG	0.438000													16	70					0	0	1	0	0
IQCH	64799	broad.mit.edu	37	15	67687761	67687761	+	Missense_Mutation	SNP	G	G	A	rs141459541		TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr15:67687761G>A	ENST00000335894.4	+	13	1831	c.1765G>A	c.(1765-1767)Gat>Aat	p.D589N	IQCH_ENST00000360277.4_Intron|IQCH_ENST00000546225.1_Intron|IQCH_ENST00000358767.3_Intron	NM_001031715.2	NP_001026885	Q86VS3	IQCH_HUMAN	IQ motif containing H	589										NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(2)|pancreas(2)|skin(5)|upper_aerodigestive_tract(1)	33				Colorectal(3;0.0856)		AGCTGTGGCCGATATGTTAGA	0.478000													15	91					0	0	1	0	0
ZNF585A	199704	broad.mit.edu	37	19	37643687	37643687	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr19:37643687G>A	ENST00000356958.4	-	5	1372	c.1114C>T	c.(1114-1116)Cat>Tat	p.H372Y	ZNF585A_ENST00000588723.1_Intron|ZNF585A_ENST00000292841.5_Missense_Mutation_p.H317Y|ZNF585A_ENST00000392157.2_Missense_Mutation_p.H317Y|ZNF585A_ENST00000355533.2_Intron			Q6P3V2	Z585A_HUMAN	zinc finger protein 585A	372					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(2)|large_intestine(17)|lung(11)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	42			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ATTCTCTGATGAATAATCAAC	0.418000													14	95					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62288125	62288125	+	Silent	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr11:62288125G>A	ENST00000378024.4	-	5	14038	c.13764C>T	c.(13762-13764)ctC>ctT	p.L4588L	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	4588					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				TCGGTGCCTTGAGGTGTAAGT	0.483000													17	130					0	0	1	0	0
C2orf71	388939	broad.mit.edu	37	2	29293759	29293759	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr2:29293759G>C	ENST00000331664.5	-	1	3368	c.3369C>G	c.(3367-3369)ttC>ttG	p.F1123L		NM_001029883.2	NP_001025054.1	A6NGG8	CB071_HUMAN	chromosome 2 open reading frame 71	1123					response to stimulus|visual perception	photoreceptor outer segment				NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						TAGCTGGGCAGAATATGGAAT	0.567000													6	51					0	0	1	0	0
NSUN2	54888	broad.mit.edu	37	5	6606938	6606938	+	Silent	SNP	A	A	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr5:6606938A>C	ENST00000264670.6	-	14	1907	c.1596T>G	c.(1594-1596)ccT>ccG	p.P532P	NSUN2_ENST00000506139.1_Silent_p.P497P|NSUN2_ENST00000539938.1_Silent_p.P296P	NM_017755.5	NP_060225.4	Q08J23	NSUN2_HUMAN	NOP2/Sun RNA methyltransferase family, member 2	532						cytoplasm|nucleolus	tRNA (cytosine-5-)-methyltransferase activity|tRNA binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(23)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	41						CTTACTCAATAGGTGGAAATA	0.294000													4	70					0	0	1	0	0
TTC7A	57217	broad.mit.edu	37	2	47238477	47238477	+	Missense_Mutation	SNP	A	A	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr2:47238477A>G	ENST00000319190.5	+	11	1663	c.1295A>G	c.(1294-1296)tAc>tGc	p.Y432C	TTC7A_ENST00000409245.1_Missense_Mutation_p.Y398C|TTC7A_ENST00000394850.2_Missense_Mutation_p.Y432C|TTC7A_ENST00000263737.6_Missense_Mutation_p.Y78C|TTC7A_ENST00000461601.1_3'UTR	NM_020458.2	NP_065191.2	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	432							binding			breast(4)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			CAGTCAGCCTACGCTGTGTCC	0.612000													3	25					0	0	1	0	0
FLT3	2322	broad.mit.edu	37	13	28626700	28626700	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr13:28626700C>G	ENST00000380982.4	-	5	677	c.596G>C	c.(595-597)tGc>tCc	p.C199S	FLT3_ENST00000537084.1_Missense_Mutation_p.C199S|FLT3_ENST00000241453.7_Missense_Mutation_p.C199S			P36888	FLT3_HUMAN	fms-related tyrosine kinase 3	199					positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(12329)|kidney(2)|large_intestine(8)|lung(30)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	12390	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	CTGTGAATCGCAAAGCACCCA	0.433000			"""Mis, O"""		"""AML, ALL"""								8	45					0	0	1	0	0
SLC25A44	9673	broad.mit.edu	37	1	156180113	156180113	+	Missense_Mutation	SNP	C	C	T	rs140016645		TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:156180113C>T	ENST00000359511.4	+	4	1008	c.836C>T	c.(835-837)tCg>tTg	p.S279L	SLC25A44_ENST00000469537.1_3'UTR|SLC25A44_ENST00000423538.2_Missense_Mutation_p.S256L	NM_014655.2	NP_055470.1	Q96H78	S2544_HUMAN	solute carrier family 25, member 44	279					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			breast(3)|kidney(2)|large_intestine(2)|lung(1)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14	Hepatocellular(266;0.158)					AAGGGCCTCTCGGCCAGAATC	0.547000													13	41					0	0	1	0	0
TMTC1	83857	broad.mit.edu	37	12	29786162	29786162	+	Missense_Mutation	SNP	A	A	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr12:29786162A>G	ENST00000256062.5	-	6	1195	c.722T>C	c.(721-723)aTa>aCa	p.I241T	TMTC1_ENST00000381224.2_Missense_Mutation_p.I303T|TMTC1_ENST00000551659.1_Missense_Mutation_p.I411T|TMTC1_ENST00000319685.8_5'UTR|TMTC1_ENST00000539277.1_Missense_Mutation_p.I349T|TMTC1_ENST00000552618.1_Missense_Mutation_p.I411T	NM_175861.3	NP_787057.2	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat containing 1	349						integral to membrane	binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(17)|lung(45)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					CATGTCCCATATGGTCTCTAC	0.498000													14	50					0	0	1	0	0
MYOF	26509	broad.mit.edu	37	10	95113641	95113641	+	Silent	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr10:95113641G>C	ENST00000371501.4	-	32	3530	c.3408C>G	c.(3406-3408)gtC>gtG	p.V1136V	MYOF_ENST00000371502.4_Silent_p.V1136V|MYOF_ENST00000359263.4_Silent_p.V1136V|MYOF_ENST00000358334.5_Silent_p.V1123V			Q9NZM1	MYOF_HUMAN	myoferlin	1136	C2 4.		V -> I (in dbSNP:rs36032890).	V -> D (in Ref. 7; CAB46370).	blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			NS(2)|autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(7)|large_intestine(15)|lung(14)|ovary(4)|prostate(4)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						GGTAGATGTAGACTCCTAAAA	0.338000													12	92					0	0	1	0	0
AEBP2	121536	broad.mit.edu	37	12	19667670	19667670	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr12:19667670C>T	ENST00000266508.9	+	7	1434	c.1433C>T	c.(1432-1434)tCa>tTa	p.S478L	AEBP2_ENST00000398864.3_Missense_Mutation_p.S478L|AEBP2_ENST00000541908.1_Missense_Mutation_p.S249L|AEBP2_ENST00000360995.4_Missense_Mutation_p.S262L	NM_153207.4	NP_694939.2	Q6ZN18	AEBP2_HUMAN	AE binding protein 2	478	Interaction with SUZ12.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)|Esophageal squamous(101;0.143)					GTTCATTTATCAAAGCTACCC	0.313000													3	27					0	0	1	0	0
ADPRHL2	54936	broad.mit.edu	37	1	36557423	36557423	+	Silent	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:36557423G>A	ENST00000373178.4	+	3	543	c.513G>A	c.(511-513)caG>caA	p.Q171Q		NM_017825.2	NP_060295.1	Q9NX46	ARHL2_HUMAN	ADP-ribosylhydrolase like 2	171						cytoplasm|nucleus	metal ion binding|poly(ADP-ribose) glycohydrolase activity			cervix(1)|endometrium(2)|large_intestine(1)|lung(3)|pancreas(1)	8		Myeloproliferative disorder(586;0.0393)				AGGATGTGCAGAAGGTATTCA	0.612000													4	28					0	0	1	0	0
ARHGAP30	257106	broad.mit.edu	37	1	161019033	161019033	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:161019033G>A	ENST00000368013.3	-	12	2098	c.1778C>T	c.(1777-1779)tCc>tTc	p.S593F	ARHGAP30_ENST00000368016.3_Missense_Mutation_p.S593F|ARHGAP30_ENST00000368015.1_Missense_Mutation_p.S416F	NM_001025598.1|NM_181720.2	NP_001020769.1|NP_859071.2	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30	593					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|cervix(3)|endometrium(4)|kidney(2)|large_intestine(4)|lung(6)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			GGGGCCAGCGGAGTCCAGGGA	0.572000													12	213					0	0	1	0	0
FLNA	2316	broad.mit.edu	37	X	153581396	153581396	+	Nonsense_Mutation	SNP	C	C	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chrX:153581396C>A	ENST00000422373.1	-	37	6423	c.6175G>T	c.(6175-6177)Gag>Tag	p.E2059*	FLNA_ENST00000360319.4_Nonsense_Mutation_p.E2059*|FLNA_ENST00000344736.4_Nonsense_Mutation_p.E2027*|FLNA_ENST00000369856.3_Nonsense_Mutation_p.E200*|FLNA_ENST00000369850.3_Nonsense_Mutation_p.E2067*	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	2067					actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ATGATAAACTCTGCAGGCTCA	0.612000													11	9					6.40141e-05	6.74169e-05	1	1	0
OR52N2	390077	broad.mit.edu	37	11	5841972	5841972	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr11:5841972C>T	ENST00000317037.2	+	1	429	c.407C>T	c.(406-408)aCc>aTc	p.T136I	TRIM5_ENST00000380027.1_Intron	NM_001005174.1	NP_001005174.1	Q8NGI0	O52N2_HUMAN	olfactory receptor, family 52, subfamily N, member 2	136					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(1)|pancreas(1)|skin(3)|stomach(1)|urinary_tract(1)	32		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.49e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CGCTATGCCACCATCCTTACC	0.547000													15	36					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1261063	1261063	+	Missense_Mutation	SNP	C	C	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr11:1261063C>A	ENST00000447027.1	+	28	3685	c.3627C>A	c.(3625-3627)ttC>ttA	p.F1209L	MUC5B_ENST00000529681.1_Missense_Mutation_p.F1206L			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	1206	Cys-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GCCAGCCCTTCTTCAATGAGG	0.607000													7	11					0.00198382	0.00202861	1	1	0
PPP1R36	145376	broad.mit.edu	37	14	65056036	65056036	+	Missense_Mutation	SNP	C	C	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr14:65056036C>A	ENST00000298705.1	+	12	1345	c.1249C>A	c.(1249-1251)Cat>Aat	p.H417N	RP11-973N13.3_ENST00000554454.1_RNA|RP11-973N13.3_ENST00000556634.1_RNA	NM_172365.1	NP_758953.1	Q96LQ0	CN050_HUMAN	protein phosphatase 1, regulatory subunit 36	417																	ACTGTCCTCTCATACATCATG	0.343000													15	90					5.03518e-11	5.56151e-11	1	1	0
C2orf16	84226	broad.mit.edu	37	2	27800241	27800241	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr2:27800241G>A	ENST00000408964.2	+	1	853	c.802G>A	c.(802-804)Gaa>Aaa	p.E268K		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	268										breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					GATTACTCCGGAACTCAAGCA	0.463000													27	61					0	0	1	0	0
RGS12	6002	broad.mit.edu	37	4	3319328	3319328	+	Missense_Mutation	SNP	T	T	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr4:3319328T>G	ENST00000336727.3	+	2	2335	c.1431T>G	c.(1429-1431)tgT>tgG	p.C477W	RGS12_ENST00000543385.1_Missense_Mutation_p.C477W|RGS12_ENST00000344733.5_Missense_Mutation_p.C477W|RGS12_ENST00000382788.3_Missense_Mutation_p.C477W	NM_002926.3	NP_002917.1	O14924	RGS12_HUMAN	regulator of G-protein signaling 12	477						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			autonomic_ganglia(1)|breast(4)|endometrium(3)|kidney(2)|large_intestine(9)|lung(16)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GGCCCTTCTGTCCGGACCCCG	0.682000													12	75					0	0	1	0	0
PRKAR1B	5575	broad.mit.edu	37	7	647068	647068	+	Silent	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr7:647068G>A	ENST00000406797.1	-	5	636	c.462C>T	c.(460-462)ttC>ttT	p.F154F	PRKAR1B_ENST00000544935.1_Silent_p.F154F|AC147651.4_ENST00000429872.1_RNA|PRKAR1B_ENST00000403562.1_Silent_p.F154F|PRKAR1B_ENST00000360274.4_Silent_p.F154F|PRKAR1B_ENST00000537384.1_Silent_p.F154F	NM_001164761.1	NP_001158233.1	P31321	KAP1_HUMAN	protein kinase, cAMP-dependent, regulatory, type I, beta	154					activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|protein phosphorylation|regulation of insulin secretion|transmembrane transport|water transport	cAMP-dependent protein kinase complex|cytosol	cAMP binding|cAMP-dependent protein kinase regulator activity			endometrium(4)|large_intestine(1)|liver(1)|lung(10)|prostate(1)	17		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|Epithelial(4;5.75e-19)|OV - Ovarian serous cystadenocarcinoma(56;2.01e-18)|all cancers(6;3.96e-16)|BRCA - Breast invasive adenocarcinoma(126;0.152)		GAGTGACAGGGAACATGGCAT	0.498000													6	76					0	0	1	0	0
CCDC30	728621	broad.mit.edu	37	1	43022020	43022020	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:43022020C>G	ENST00000428554.2	+	12	1762	c.619C>G	c.(619-621)Cag>Gag	p.Q207E	CCDC30_ENST00000340612.4_Missense_Mutation_p.Q207E|CCDC30_ENST00000390640.4_Intron|CCDC30_ENST00000507855.1_Intron|CCDC30_ENST00000342022.4_Missense_Mutation_p.Q207E			Q5VVM6	CCD30_HUMAN	coiled-coil domain containing 30	207										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(2)	30						CCATATAAATCAGAGCCTTCT	0.453000													9	43					0	0	1	0	0
WDR17	116966	broad.mit.edu	37	4	177041056	177041056	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr4:177041056G>A	ENST00000393643.2	+	4	598	c.346G>A	c.(346-348)Gat>Aat	p.D116N	WDR17_ENST00000508596.1_Missense_Mutation_p.D116N|WDR17_ENST00000280190.4_Missense_Mutation_p.D140N|WDR17_ENST00000507824.2_Missense_Mutation_p.D140N	NM_170710.4	NP_733828.2	Q8IZU2	WDR17_HUMAN	WD repeat domain 17	140										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(18)|lung(46)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	92		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		GAATGCAGAGGATGTGGTGGC	0.408000													10	93					0	0	1	0	0
FCER1G	2207	broad.mit.edu	37	1	161187860	161187860	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:161187860G>A	ENST00000289902.1	+	2	159	c.134G>A	c.(133-135)cGa>cAa	p.R45Q	FCER1G_ENST00000367992.3_Missense_Mutation_p.R45Q|FCER1G_ENST00000490414.1_Intron	NM_004106.1	NP_004097.1	P30273	FCERG_HUMAN	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	45					platelet activation	integral to plasma membrane				endometrium(1)|lung(5)	6	all_cancers(52;1.35e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Benzylpenicilloyl Polylysine(DB00895)	CTCTACTGTCGACTGAAGGTA	0.567000													12	205					0	0	1	0	0
ZNF175	7728	broad.mit.edu	37	19	52091120	52091120	+	Silent	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr19:52091120C>T	ENST00000262259.2	+	5	1894	c.1536C>T	c.(1534-1536)ttC>ttT	p.F512F	ZNF175_ENST00000436511.2_Intron	NM_007147.2	NP_009078.1	Q9Y473	ZN175_HUMAN	zinc finger protein 175	512					response to virus	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	24		all_neural(266;0.0299)		GBM - Glioblastoma multiforme(134;0.000426)|OV - Ovarian serous cystadenocarcinoma(262;0.0257)		GAAAAACCTTCACCCAAAAGT	0.413000													10	33					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32666516	32666516	+	Silent	SNP	A	A	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr2:32666516A>G	ENST00000421745.2	+	17	4064	c.3930A>G	c.(3928-3930)tcA>tcG	p.S1310S		NM_016252.3	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	1310					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					AGAAAACCTCAATTTCTAAGG	0.358000													14	33					0	0	1	0	0
BUB1B	701	broad.mit.edu	37	15	40468811	40468811	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr15:40468811C>T	ENST00000287598.6	+	5	713	c.518C>T	c.(517-519)gCg>gTg	p.A173V	BUB1B_ENST00000560120.1_3'UTR|BUB1B_ENST00000412359.3_Missense_Mutation_p.A187V	NM_001211.5	NP_001202	O60566	BUB1B_HUMAN	BUB1 mitotic checkpoint serine/threonine kinase B	173	BUB1 N-terminal.|Necessary for interaction with CASC5.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(7)|liver(2)|lung(17)|ovary(1)|stomach(2)|urinary_tract(2)	36		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)		AAAGCAGATGCGATATTTCAG	0.408000			"""Mis, N, F, S"""			rhabdomyosarcoma			Mosaic Variegated Aneuploidy Syndrome				8	72					0	0	1	0	0
CYP2C19	1557	broad.mit.edu	37	10	96540357	96540357	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr10:96540357C>G	ENST00000371321.3	+	4	665	c.583C>G	c.(583-585)Ctt>Gtt	p.L195V	CYP2C19_ENST00000464755.1_3'UTR	NM_000769.1	NP_000760	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 19	195					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	43		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	TCAGCAATTTCTTAACTTGAT	0.418000													22	157					0	0	1	0	0
ZNF532	55205	broad.mit.edu	37	18	56606717	56606717	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr18:56606717C>G	ENST00000336078.4	+	6	3345	c.2569C>G	c.(2569-2571)Ctg>Gtg	p.L857V	ZNF532_ENST00000591083.1_Missense_Mutation_p.L857V|ZNF532_ENST00000591230.1_Missense_Mutation_p.L857V|ZNF532_ENST00000589288.1_Missense_Mutation_p.L857V|ZNF532_ENST00000591808.1_Missense_Mutation_p.L857V	NM_018181.4	NP_060651.2	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	857					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(14)|kidney(1)|large_intestine(9)|lung(14)|prostate(1)|skin(4)|urinary_tract(1)	52						TGTGGCTGCTCTGAAGTCTCA	0.438000													15	91					0	0	1	0	0
RASA3	22821	broad.mit.edu	37	13	114792882	114792882	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr13:114792882C>T	ENST00000334062.7	-	7	707	c.586G>A	c.(586-588)Gaa>Aaa	p.E196K	RASA3_ENST00000389544.4_Missense_Mutation_p.E164K|RASA3_ENST00000542651.1_3'UTR	NM_007368.2	NP_031394.2	Q14644	RASA3_HUMAN	RAS p21 protein activator 3	196	C2 2.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	calcium-release channel activity|metal ion binding|Ras GTPase activator activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(20)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	47	Lung NSC(43;0.00814)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.016)|all_epithelial(44;0.00577)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.188)	BRCA - Breast invasive adenocarcinoma(86;0.128)			TAAAACACTTCATCGAACTGG	0.428000													8	76					0	0	1	0	0
PRRC2B	84726	broad.mit.edu	37	9	134363319	134363319	+	Missense_Mutation	SNP	C	C	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr9:134363319C>A	ENST00000357304.4	+	27	6116	c.6061C>A	c.(6061-6063)Cca>Aca	p.P2021T	PRRC2B_ENST00000405995.1_Missense_Mutation_p.P1327T|PRRC2B_ENST00000372249.1_Missense_Mutation_p.P118T|PRRC2B_ENST00000458550.1_Missense_Mutation_p.P1327T	NM_013318.3	NP_037450.2	Q5JSZ5	PRC2B_HUMAN	proline-rich coiled-coil 2B	2021							protein binding			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(20)|ovary(2)	44						CTTGAAGCCTCCATACTCGGC	0.607000													7	29					2.0095e-06	2.14482e-06	1	1	0
RPS8	6202	broad.mit.edu	37	1	45243706	45243706	+	Missense_Mutation	SNP	G	G	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:45243706G>T	ENST00000396651.3	+	5	582	c.422G>T	c.(421-423)cGa>cTa	p.R141L	RPS8_ENST00000372209.3_Missense_Mutation_p.R121L|RPS8_ENST00000485390.1_3'UTR			P62241	RS8_HUMAN	ribosomal protein S8	141					endocrine pancreas development|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	protein binding|structural constituent of ribosome			central_nervous_system(2)|large_intestine(1)|lung(4)|ovary(2)|prostate(1)	10	Acute lymphoblastic leukemia(166;0.155)					AACAAAAAACGATCTAAAAAA	0.433000													18	23					3.32936e-07	3.57765e-07	1	1	0
PPM1B	5495	broad.mit.edu	37	2	44457786	44457786	+	Nonsense_Mutation	SNP	G	G	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr2:44457786G>T	ENST00000282412.4	+	6	1781	c.1369G>T	c.(1369-1371)Gaa>Taa	p.E457*	PPM1B_ENST00000409432.3_3'UTR|PPM1B_ENST00000378551.2_Intron|PPM1B_ENST00000378540.4_Intron|PPM1B_ENST00000345249.4_Nonsense_Mutation_p.E170*	NM_002706.4	NP_002697.1	O75688	PPM1B_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1B	457					protein dephosphorylation	protein serine/threonine phosphatase complex	magnesium ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity			kidney(4)|large_intestine(3)|lung(7)|skin(2)	16		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				TACTGAATCAGAAAGTGGTCT	0.428000													6	74					0.00307968	0.00312903	1	1	0
APOA2	336	broad.mit.edu	37	1	161192749	161192749	+	Silent	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:161192749C>G	ENST00000464492.1	-	3	281	c.243G>C	c.(241-243)ctG>ctC	p.L81L	APOA2_ENST00000367990.3_Silent_p.L48L|APOA2_ENST00000463812.1_5'UTR|APOA2_ENST00000470459.2_Silent_p.L48L|APOA2_ENST00000491350.1_Intron|APOA2_ENST00000468465.1_5'UTR			P02652	APOA2_HUMAN	apolipoprotein A-II						cholesterol efflux|cholesterol homeostasis|diacylglycerol catabolic process|high-density lipoprotein particle assembly|high-density lipoprotein particle clearance|high-density lipoprotein particle remodeling|interspecies interaction between organisms|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol import|negative regulation of cholesterol transporter activity|negative regulation of cytokine secretion involved in immune response|negative regulation of lipase activity|negative regulation of lipid catabolic process|negative regulation of very-low-density lipoprotein particle remodeling|phosphatidylcholine biosynthetic process|phospholipid catabolic process|phospholipid efflux|positive regulation of cholesterol esterification|positive regulation of interleukin-8 biosynthetic process|positive regulation of lipid catabolic process|protein folding|regulation of protein stability|response to glucose stimulus|reverse cholesterol transport|triglyceride metabolic process|triglyceride-rich lipoprotein particle remodeling	chylomicron|endoplasmic reticulum lumen|spherical high-density lipoprotein particle|very-low-density lipoprotein particle	apolipoprotein receptor binding|cholesterol binding|high-density lipoprotein particle receptor binding|lipase inhibitor activity|phosphatidylcholine binding|phosphatidylcholine-sterol O-acyltransferase activator activity|protein heterodimerization activity|protein homodimerization activity			endometrium(1)|large_intestine(1)|lung(2)|skin(2)	6	all_cancers(52;1.86e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			CCTTCTCCATCAGGTCCTTGC	0.557000													7	198					0	0	1	0	0
NCAPG2	54892	broad.mit.edu	37	7	158494578	158494578	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr7:158494578C>G	ENST00000409339.3	-	2	126	c.13G>C	c.(13-15)Gag>Cag	p.E5Q	NCAPG2_ENST00000356309.3_Missense_Mutation_p.E5Q|NCAPG2_ENST00000449727.2_Missense_Mutation_p.E5Q|NCAPG2_ENST00000409423.1_Missense_Mutation_p.E5Q	NM_001281933.1	NP_001268862.1	Q86XI2	CNDG2_HUMAN	non-SMC condensin II complex, subunit G2	5					cell division|chromosome condensation|mitosis	nucleus	methylated histone residue binding			NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(7)|liver(1)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	39	Ovarian(565;0.152)	all_cancers(7;3.44e-11)|all_epithelial(9;3.05e-05)|all_hematologic(28;0.014)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.187)|STAD - Stomach adenocarcinoma(7;0.18)		ACAAACGTCTCACGTTTTTCC	0.353000													4	59					0	0	1	0	0
AKT3	10000	broad.mit.edu	37	1	243708880	243708880	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:243708880C>T	ENST00000366539.1	-	12	1383	c.1183G>A	c.(1183-1185)Gat>Aat	p.D395N	AKT3_ENST00000263826.5_Missense_Mutation_p.D395N|AKT3_ENST00000366540.1_Missense_Mutation_p.D395N|RP11-269F20.1_ENST00000439849.1_RNA|AKT3_ENST00000336199.5_Missense_Mutation_p.D395N			Q9Y243	AKT3_HUMAN	v-akt murine thymoma viral oncogene homolog 3	395	Protein kinase.				signal transduction	Golgi apparatus|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|skin(3)|stomach(1)	26	all_cancers(71;0.000307)|all_epithelial(71;0.000374)|all_lung(81;0.0323)|Ovarian(71;0.0619)|all_neural(11;0.101)|Lung NSC(105;0.168)	all_cancers(173;0.0274)	all cancers(7;4.3e-08)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00196)			TCTTTTGCATCATCTGGTCCT	0.303000													11	70					0	0	1	0	0
CREBBP	1387	broad.mit.edu	37	16	3817738	3817738	+	Nonsense_Mutation	SNP	G	G	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr16:3817738G>T	ENST00000262367.5	-	16	4042	c.3233C>A	c.(3232-3234)tCg>tAg	p.S1078*	CREBBP_ENST00000382070.3_Nonsense_Mutation_p.S1040*	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	1078					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		GCGCGGCTGCGAAGGAGATGT	0.423000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						26	74					1.2476e-16	1.38283e-16	1	1	0
SETD2	29072	broad.mit.edu	37	3	47142964	47142964	+	Nonsense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr3:47142964G>A	ENST00000409792.3	-	8	5041	c.4999C>T	c.(4999-5001)Cag>Tag	p.Q1667*		NM_014159.6	NP_054878.5	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1667	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding	p.Q1667*(1)|p.Q1164*(1)		breast(6)|central_nervous_system(5)|endometrium(4)|kidney(63)|large_intestine(18)|lung(26)|ovary(6)|prostate(2)|skin(3)|soft_tissue(1)|stomach(2)|urinary_tract(5)	141		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		CTCTGGAACTGATAGTCAAAC	0.373000			"""N, F, S, Mis"""		clear cell renal carcinoma								37	108					0	0	1	0	0
C2orf16	84226	broad.mit.edu	37	2	27799490	27799490	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr2:27799490G>C	ENST00000408964.2	+	1	102	c.51G>C	c.(49-51)ttG>ttC	p.L17F		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	17										breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					ATCAAGAGTTGACTTCAGGAT	0.428000													14	32					0	0	1	0	0
OR51B4	79339	broad.mit.edu	37	11	5322367	5322367	+	Silent	SNP	G	G	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr11:5322367G>T	ENST00000380224.1	-	1	859	c.810C>A	c.(808-810)ccC>ccA	p.P270P	HBG2_ENST00000380252.1_Intron|HBG2_ENST00000380259.2_Intron|HBE1_ENST00000380237.1_Intron	NM_033179.2	NP_149419.2	Q9Y5P0	O51B4_HUMAN	olfactory receptor, family 51, subfamily B, member 4	270					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	20		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCATGGTAATGGGGACCACAT	0.418000													10	46					2.17888e-05	2.3178e-05	1	1	0
TLR10	81793	broad.mit.edu	37	4	38774934	38774934	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr4:38774934C>T	ENST00000308973.4	-	4	2883	c.2278G>A	c.(2278-2280)Gat>Aat	p.D760N	TLR10_ENST00000508334.1_Missense_Mutation_p.D760N|TLR10_ENST00000506111.1_Missense_Mutation_p.D760N|TLR10_ENST00000361424.2_Missense_Mutation_p.D760N	NM_001017388.2|NM_001195107.1|NM_030956.3	NP_001017388.1|NP_001182036.1|NP_112218.2	Q9BXR5	TLR10_HUMAN	toll-like receptor 10	760	TIR.				inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane	transmembrane receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(2)	25						TTACGCCTATCCTTGGGCCAT	0.413000													22	53					0	0	1	0	0
UBE2M	9040	broad.mit.edu	37	19	59068511	59068511	+	Silent	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr19:59068511C>T	ENST00000253023.3	-	2	701	c.123G>A	c.(121-123)ctG>ctA	p.L41L		NM_003969.3	NP_003960.1	P61081	UBC12_HUMAN	ubiquitin-conjugating enzyme E2M	41	Interaction with UBA3.				protein neddylation		ATP binding|NEDD8 ligase activity|protein binding|ribosomal S6-glutamic acid ligase activity|ubiquitin-protein ligase activity			large_intestine(1)|lung(2)|ovary(1)|pancreas(1)	5		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)		TGGGCAGGTTCAGCTCGTTTA	0.547000													16	71					0	0	1	0	0
UBXN2B	137886	broad.mit.edu	37	8	59329436	59329436	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr8:59329436G>A	ENST00000399598.2	+	2	234	c.112G>A	c.(112-114)Gaa>Aaa	p.E38K	UBXN2B_ENST00000522978.1_3'UTR	NM_001077619.1	NP_001071087.1	Q14CS0	UBX2B_HUMAN	UBX domain protein 2B	38						cytosol|endoplasmic reticulum|Golgi apparatus|nucleus				endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	13						GTATGAAGATGAAGTGAAGTG	0.378000													13	56					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152284912	152284912	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:152284912C>G	ENST00000368799.1	-	3	2485	c.2450G>C	c.(2449-2451)aGa>aCa	p.R817T	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	817	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGATCCTTGTCTTACTCCAGT	0.562000									Ichthyosis				44	164					0	0	1	0	0
DENND4A	10260	broad.mit.edu	37	15	66048724	66048724	+	Nonsense_Mutation	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr15:66048724G>C	ENST00000443035.3	-	3	280	c.65C>G	c.(64-66)tCa>tGa	p.S22*	DENND4A_ENST00000431932.2_Nonsense_Mutation_p.S22*	NM_001144823.1	NP_001138295.1	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A	22					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(11)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	51						TAGAGGCTTTGAAACATCAGT	0.353000													10	42					0	0	1	0	0
FRMD4A	55691	broad.mit.edu	37	10	13782564	13782564	+	Missense_Mutation	SNP	T	T	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr10:13782564T>C	ENST00000357447.2	-	10	930	c.562A>G	c.(562-564)Att>Gtt	p.I188V	FRMD4A_ENST00000342409.2_Missense_Mutation_p.I204V|FRMD4A_ENST00000378503.1_Missense_Mutation_p.I188V|FRMD4A_ENST00000358621.4_Missense_Mutation_p.I173V|RP11-353M9.1_ENST00000449462.1_RNA	NM_018027.3	NP_060497.3	Q9P2Q2	FRM4A_HUMAN	FERM domain containing 4A	188	FERM.					cytoplasm|cytoskeleton	binding			breast(4)|endometrium(9)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	41						TAGTGCTCAATGACTCTGTCT	0.458000													7	59					0	0	1	0	0
SLC22A2	6582	broad.mit.edu	37	6	160645759	160645759	+	Missense_Mutation	SNP	C	C	T	rs144834632		TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr6:160645759C>T	ENST00000366953.3	-	10	1837	c.1579G>A	c.(1579-1581)Gag>Aag	p.E527K	SLC22A2_ENST00000491092.1_5'UTR	NM_003058.3	NP_003049.2	O15244	S22A2_HUMAN	solute carrier family 22 (organic cation transporter), member 2	527					body fluid secretion|neurotransmitter biosynthetic process|neurotransmitter secretion	integral to plasma membrane|membrane fraction	neurotransmitter transporter activity|organic cation transmembrane transporter activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(16)|prostate(2)|skin(1)	27		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.28e-17)|BRCA - Breast invasive adenocarcinoma(81;6.29e-06)		TCGGCTTCCTCGATGGTCTCA	0.413000													9	107					0	0	1	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12854398	12854398	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:12854398C>G	ENST00000332296.7	+	3	725	c.622C>G	c.(622-624)Caa>Gaa	p.Q208E		NM_023013.2	NP_075389.1	O95521	PRAM1_HUMAN	PRAME family member 1	208										cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	35	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GAATAGTATTCAAGAGCTGGA	0.398000													49	443					0	0	1	0	0
ALG2	85365	broad.mit.edu	37	9	101980878	101980878	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr9:101980878C>G	ENST00000476832.1	-	2	650	c.589G>C	c.(589-591)Gat>Cat	p.D197H	ALG2_ENST00000319033.6_Missense_Mutation_p.D104H	NM_033087.3	NP_149078.1	Q9H553	ALG2_HUMAN	ALG2, alpha-1,3/1,6-mannosyltransferase	197					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in endoplasmic reticulum|protein N-linked glycosylation via asparagine|response to calcium ion	endoplasmic reticulum membrane|integral to membrane|membrane fraction|nucleus|perinuclear region of cytoplasm	alpha-1,3-mannosyltransferase activity|calcium-dependent protein binding|glycolipid 3-alpha-mannosyltransferase activity|protein anchor|protein heterodimerization activity|protein N-terminus binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(11)|ovary(2)|prostate(2)	22		Acute lymphoblastic leukemia(62;0.0559)				TAGAGGACATCAGGGTCTATG	0.468000													7	60					0	0	1	0	0
VEPH1	79674	broad.mit.edu	37	3	157099133	157099133	+	Silent	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr3:157099133C>T	ENST00000362010.2	-	7	1246	c.939G>A	c.(937-939)gtG>gtA	p.V313V	VEPH1_ENST00000543418.1_Silent_p.V313V|VEPH1_ENST00000392832.2_Silent_p.V313V|VEPH1_ENST00000392833.2_Silent_p.V313V	NM_001167912.1	NP_001161384.1	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain-containing 1	313						plasma membrane				autonomic_ganglia(1)|breast(5)|cervix(1)|kidney(3)|large_intestine(9)|lung(22)|ovary(1)|pancreas(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	48			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			CCAGTTGGCTCACCAGGTATG	0.468000													10	74					0	0	1	0	0
FBXL7	23194	broad.mit.edu	37	5	15936942	15936942	+	Missense_Mutation	SNP	T	T	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr5:15936942T>C	ENST00000504595.1	+	4	1604	c.1123T>C	c.(1123-1125)Tgc>Cgc	p.C375R	FBXL7_ENST00000329673.7_Missense_Mutation_p.C363R|FBXL7_ENST00000510662.1_Missense_Mutation_p.C328R	NM_001278317.1|NM_012304.3	NP_001265246.1|NP_036436.1	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	375					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(13)|lung(33)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	60						GGCCAAGTACTGCAGCAAGCT	0.647000													13	23					0	0	1	0	0
MED23	9439	broad.mit.edu	37	6	131929070	131929070	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr6:131929070C>G	ENST00000403834.3	-	12	1410	c.1237G>C	c.(1237-1239)Gaa>Caa	p.E413Q	MED23_ENST00000540546.1_Missense_Mutation_p.E413Q|MED23_ENST00000354577.4_Missense_Mutation_p.E413Q|MED23_ENST00000368068.3_Missense_Mutation_p.E407Q|MED23_ENST00000368058.1_Missense_Mutation_p.E413Q|MED23_ENST00000368060.3_Missense_Mutation_p.E407Q|MED23_ENST00000368053.4_Missense_Mutation_p.E413Q|MED23_ENST00000539158.1_Missense_Mutation_p.E407Q|MED23_ENST00000545957.1_Intron			Q9ULK4	MED23_HUMAN	mediator complex subunit 23	407					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor complex	protein binding|transcription coactivator activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(12)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	44	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0115)|OV - Ovarian serous cystadenocarcinoma(155;0.0608)		AAGCTTACTTCTTTTTCTGGG	0.333000													7	44					0	0	1	0	0
CP	1356	broad.mit.edu	37	3	148925367	148925367	+	Silent	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr3:148925367G>C	ENST00000264613.6	-	5	1081	c.819C>G	c.(817-819)ctC>ctG	p.L273L		NM_000096.3	NP_000087	P00450	CERU_HUMAN	ceruloplasmin (ferroxidase)	273	F5/8 type A 1.|Plastocyanin-like 2.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	extracellular space	chaperone binding|ferroxidase activity			breast(6)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		Prostate(884;0.00217)|Hepatocellular(537;0.00826)|Myeloproliferative disorder(1037;0.0122)|all_neural(597;0.0189)|Melanoma(1037;0.152)	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Drotrecogin alfa(DB00055)	CACACATGGAGAGTCCTGGGA	0.433000													8	65					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79258893	79258893	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr4:79258893C>T	ENST00000264895.6	+	20	2784	c.2344C>T	c.(2344-2346)Cac>Tac	p.H782Y	FRAS1_ENST00000325942.6_Missense_Mutation_p.H782Y	NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	782					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						CTGTTACCCTCACATCTCTCT	0.542000													11	77					0	0	1	0	0
DGKB	1607	broad.mit.edu	37	7	14620543	14620543	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr7:14620543G>A	ENST00000403951.2	-	19	1975	c.1556C>T	c.(1555-1557)gCg>gTg	p.A519V	DGKB_ENST00000258767.5_Missense_Mutation_p.A519V|DGKB_ENST00000399322.3_Missense_Mutation_p.A519V|DGKB_ENST00000402815.1_Missense_Mutation_p.A518V|DGKB_ENST00000444700.2_Missense_Mutation_p.A500V|DGKB_ENST00000403963.1_5'UTR|DGKB_ENST00000407950.1_Missense_Mutation_p.A511V|DGKB_ENST00000406247.3_Missense_Mutation_p.A519V			Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta 90kDa	519	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(34)|ovary(4)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72					Phosphatidylserine(DB00144)	AGGCAGAATCGCAACTGGAGG	0.408000													7	53					0	0	1	0	0
CFAP221	200373	broad.mit.edu	37	2	120404546	120404546	+	Silent	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr2:120404546C>T	ENST00000602047.1	+	23	2492	c.1380C>T	c.(1378-1380)ttC>ttT	p.F460F	PCDP1_ENST00000413369.3_Silent_p.F746F			Q4G0U5	PCDP1_HUMAN		746						cilium	calmodulin binding					Colorectal(110;0.196)					GCGATTCCTTCAATTCATTTA	0.363000													4	67					0	0	1	0	0
OR10K1	391109	broad.mit.edu	37	1	158436236	158436236	+	Silent	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:158436236G>A	ENST00000289451.2	+	1	965	c.885G>A	c.(883-885)aaG>aaA	p.K295K		NM_001004473.1	NP_001004473.1	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K, member 1	295					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	27	all_hematologic(112;0.0378)					TGAGAAATAAGGAATTCAAAT	0.378000													46	130					0	0	1	0	0
RNF149	284996	broad.mit.edu	37	2	101924811	101924811	+	Silent	SNP	C	C	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr2:101924811C>A	ENST00000295317.3	-	1	347	c.240G>T	c.(238-240)ccG>ccT	p.P80P		NM_173647.3	NP_775918.2	Q8NC42	RN149_HUMAN	ring finger protein 149	80	PA.					integral to membrane	ligase activity|zinc ion binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)	12						CGGGCGCCCACGGGACGCCCA	0.761000													6	16					0.00116845	0.00120651	1	1	0
PC	5091	broad.mit.edu	37	11	66618639	66618639	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr11:66618639C>T	ENST00000393960.1	-	17	2376	c.2095G>A	c.(2095-2097)Gtg>Atg	p.V699M	PC_ENST00000393955.2_Missense_Mutation_p.V699M|PC_ENST00000393958.2_Missense_Mutation_p.V699M	NM_001040716.1	NP_001035806.1	P11498	PYC_HUMAN	pyruvate carboxylase	699	Carboxyltransferase.				gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	GCCTCCACCACGCCTCCGGCA	0.607000													17	56					0	0	1	0	0
C16orf46	123775	broad.mit.edu	37	16	81097383	81097383	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr16:81097383C>G	ENST00000378611.4	-	2	293	c.178G>C	c.(178-180)Gag>Cag	p.E60Q	RP11-303E16.8_ENST00000564536.1_RNA|C16orf46_ENST00000299578.5_Missense_Mutation_p.E60Q|C16orf46_ENST00000444657.3_Intron	NM_001100873.1	NP_001094343.1	Q6P387	CP046_HUMAN	chromosome 16 open reading frame 46	60										NS(1)|endometrium(2)|large_intestine(3)|lung(9)|prostate(1)|stomach(1)|urinary_tract(1)	18						ATAATAAACTCTTTGGCTTTT	0.393000													6	60					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34080579	34080579	+	Silent	SNP	C	C	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr15:34080579C>A	ENST00000389232.4	+	67	9820	c.9750C>A	c.(9748-9750)ctC>ctA	p.L3250L	RYR3_ENST00000415757.3_Silent_p.L3250L	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	3250					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CAGAACTCCTCATCCTGGACG	0.557000													8	45					0.00307968	0.00312903	1	1	0
COL3A1	1281	broad.mit.edu	37	2	189849538	189849538	+	Silent	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr2:189849538C>G	ENST00000304636.3	+	2	302	c.132C>G	c.(130-132)gtC>gtG	p.V44V	COL3A1_ENST00000317840.5_Silent_p.V44V	NM_000090.3	NP_000081	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	44	VWFC.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	ATAGAGATGTCTGGAAGCCAG	0.448000													9	57					0	0	1	0	0
MINK1	50488	broad.mit.edu	37	17	4789241	4789241	+	Silent	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr17:4789241G>A	ENST00000355280.6	+	8	871	c.675G>A	c.(673-675)gaG>gaA	p.E225E	MINK1_ENST00000453408.3_Silent_p.E225E|MINK1_ENST00000347992.7_Silent_p.E225E	NM_001024937.3|NM_015716.4|NM_153827.4	NP_001020108.1|NP_056531.1|NP_722549.2	Q8N4C8	MINK1_HUMAN	misshapen-like kinase 1	225	Protein kinase.				JNK cascade	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)|stomach(1)	6						CAGCCATCGAGATGGCAGAGG	0.552000													8	24					0	0	1	0	0
APOA2	336	broad.mit.edu	37	1	161192237	161192237	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:161192237C>G	ENST00000464492.1	-	4	398	c.360G>C	c.(358-360)ttG>ttC	p.L120F	APOA2_ENST00000367990.3_Missense_Mutation_p.L87F|APOA2_ENST00000463812.1_Missense_Mutation_p.L39F|APOA2_ENST00000470459.2_Missense_Mutation_p.L69F|APOA2_ENST00000491350.1_3'UTR|APOA2_ENST00000468465.1_Missense_Mutation_p.L39F|AL590714.1_ENST00000594609.1_Missense_Mutation_p.Q58E			P02652	APOA2_HUMAN	apolipoprotein A-II						cholesterol efflux|cholesterol homeostasis|diacylglycerol catabolic process|high-density lipoprotein particle assembly|high-density lipoprotein particle clearance|high-density lipoprotein particle remodeling|interspecies interaction between organisms|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol import|negative regulation of cholesterol transporter activity|negative regulation of cytokine secretion involved in immune response|negative regulation of lipase activity|negative regulation of lipid catabolic process|negative regulation of very-low-density lipoprotein particle remodeling|phosphatidylcholine biosynthetic process|phospholipid catabolic process|phospholipid efflux|positive regulation of cholesterol esterification|positive regulation of interleukin-8 biosynthetic process|positive regulation of lipid catabolic process|protein folding|regulation of protein stability|response to glucose stimulus|reverse cholesterol transport|triglyceride metabolic process|triglyceride-rich lipoprotein particle remodeling	chylomicron|endoplasmic reticulum lumen|spherical high-density lipoprotein particle|very-low-density lipoprotein particle	apolipoprotein receptor binding|cholesterol binding|high-density lipoprotein particle receptor binding|lipase inhibitor activity|phosphatidylcholine binding|phosphatidylcholine-sterol O-acyltransferase activator activity|protein heterodimerization activity|protein homodimerization activity			endometrium(1)|large_intestine(1)|lung(2)|skin(2)	6	all_cancers(52;1.86e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			CGAAATAGCTCAAGAAGTTAA	0.507000													13	313					0	0	1	0	0
TXNDC9	10190	broad.mit.edu	37	2	99938530	99938530	+	Missense_Mutation	SNP	C	C	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr2:99938530C>A	ENST00000264255.3	-	4	706	c.451G>T	c.(451-453)Gat>Tat	p.D151Y	TXNDC9_ENST00000434323.1_3'UTR|C2orf15_ENST00000465095.1_Intron|TXNDC9_ENST00000409434.1_Missense_Mutation_p.D151Y	NM_005783.3	NP_005774.2	O14530	TXND9_HUMAN	thioredoxin domain containing 9	151	Thioredoxin.				cell redox homeostasis		protein binding			lung(1)	1						GTTTTCCCATCTTTTAGCAGT	0.408000													5	98					0.00116845	0.00120651	1	1	0
FRAS1	80144	broad.mit.edu	37	4	79258928	79258928	+	Silent	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr4:79258928C>T	ENST00000264895.6	+	20	2819	c.2379C>T	c.(2377-2379)agC>agT	p.S793S	FRAS1_ENST00000325942.6_Silent_p.S793S	NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	793					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						GCAGGACCAGCTGCAGGGAAG	0.562000													10	59					0	0	1	0	0
MDGA2	161357	broad.mit.edu	37	14	47426736	47426736	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr14:47426736C>T	ENST00000426342.1	-	9	1782	c.1036G>A	c.(1036-1038)Gag>Aag	p.E346K	MDGA2_ENST00000357362.3_Missense_Mutation_p.E346K|MDGA2_ENST00000439988.3_Missense_Mutation_p.E644K|MDGA2_ENST00000399232.2_Missense_Mutation_p.E575K	NM_182830.3	NP_878250.2	Q7Z553	MDGA2_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 2	575	Ig-like 4.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				breast(3)|endometrium(4)|kidney(2)|large_intestine(14)|lung(41)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(5)	76						AAGCGCCACTCATAGGTCAGC	0.468000													27	59					0	0	1	0	0
THEM5	284486	broad.mit.edu	37	1	151823664	151823664	+	Missense_Mutation	SNP	T	T	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:151823664T>C	ENST00000368817.5	-	3	460	c.329A>G	c.(328-330)aAa>aGa	p.K110R		NM_182578.3	NP_872384	Q8N1Q8	THEM5_HUMAN	thioesterase superfamily member 5	110							hydrolase activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(2)	15	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			ACAGTCACCTTTGTCTGGGGA	0.507000													29	66					0	0	1	0	0
SLC6A6	6533	broad.mit.edu	37	3	14518848	14518848	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr3:14518848G>C	ENST00000454876.2	+	11	1674	c.1345G>C	c.(1345-1347)Gag>Cag	p.E449Q	SLC6A6_ENST00000360861.3_Missense_Mutation_p.E449Q			P31641	SC6A6_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 6	449					cellular amino acid metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity|taurine:sodium symporter activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|skin(2)	28						GATGGTGACGGAGGTAGGTGG	0.572000													7	29					0	0	1	0	0
MST1L	11223	broad.mit.edu	37	1	17083685	17083685	+	RNA	SNP	C	C	A	rs3197973	by1000genomes	TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:17083685C>A	ENST00000455405.2	-	0	903																											ACTGTACTTACAAGTTTTGTC	0.403000													4	28					1.024e-07	1.10788e-07	1	1	0
MAP6	4135	broad.mit.edu	37	11	75319253	75319253	+	Silent	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr11:75319253G>A	ENST00000434603.2	-	2	1084	c.1020C>T	c.(1018-1020)ttC>ttT	p.F340F	MAP6_ENST00000526740.1_Silent_p.F11F|MAP6_ENST00000304771.3_Silent_p.F340F	NM_207577.1	NP_997460.1	Q96JE9	MAP6_HUMAN	microtubule-associated protein 6	340						Golgi apparatus|microtubule|perinuclear region of cytoplasm	calmodulin binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|prostate(1)|skin(1)|urinary_tract(1)	19	Ovarian(111;0.11)					CCTCTCCTTTGAACTGAGCAC	0.507000													8	54					0	0	1	0	0
FAM27L	284123	broad.mit.edu	37	17	21826220	21826220	+	RNA	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr17:21826220G>A	ENST00000426869.3	+	0	403					NR_028336.1				family with sequence similarity 27-like											central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)	14				UCEC - Uterine corpus endometrioid carcinoma (53;0.11)|BRCA - Breast invasive adenocarcinoma(1;0.00463)		TCTGAGAAGTGAAGCCACACC	0.527000													5	39					0	0	1	0	0
CDH22	64405	broad.mit.edu	37	20	44869807	44869807	+	Silent	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr20:44869807C>G	ENST00000372262.3	-	2	745	c.345G>C	c.(343-345)ctG>ctC	p.L115L	CDH22_ENST00000537909.1_Silent_p.L115L	NM_021248.1	NP_067071.1	Q9UJ99	CAD22_HUMAN	cadherin 22, type 2	115	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	44		Myeloproliferative disorder(115;0.0122)				TGTCGCCTGTCAGCTCGTCGA	0.627000													4	33					0	0	1	0	0
NUTM2A-AS1	728190	broad.mit.edu	37	10	88975905	88975905	+	RNA	SNP	C	C	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr10:88975905C>A	ENST00000451940.2	-	0	600																											TGTTGTGGTTCATCAGAGACA	0.552000													3	22					0.150653	0.152093	1	1	0
TRAV36DV7	28646	broad.mit.edu	37	14	22694689	22694689	+	RNA	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr14:22694689C>G	ENST00000390463.3	+	0	49																											TACTAGCTATCTTTTGGCTTC	0.428000													4	23					0	0	1	0	0
NLRP9	338321	broad.mit.edu	37	19	56228162	56228162	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr19:56228162C>G	ENST00000332836.2	-	5	2289	c.2262G>C	c.(2260-2262)ttG>ttC	p.L754F		NM_176820.2	NP_789790.2	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	754						cytoplasm	ATP binding			NS(2)|breast(5)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(15)|lung(21)|ovary(2)|prostate(3)|skin(7)|urinary_tract(3)	74		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		CTTCGTCCCTCAAGGGATTTT	0.532000													9	59					0	0	1	0	0
NRROS	375387	broad.mit.edu	37	3	196388303	196388303	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr3:196388303G>A	ENST00000328557.4	+	3	1992	c.1789G>A	c.(1789-1791)Gac>Aac	p.D597N		NM_198565.1	NP_940967.1			negative regulator of reactive oxygen species																		GAATCCATATGACTGCTGTGG	0.607000													14	60					0	0	1	0	0
APOA2	336	broad.mit.edu	37	1	161192273	161192273	+	Nonsense_Mutation	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:161192273C>T	ENST00000594609.1	+	2	208	c.208C>T	c.(208-210)Cag>Tag	p.Q70*	APOA2_ENST00000367990.3_Silent_p.L75L|APOA2_ENST00000463812.1_Silent_p.L27L|APOA2_ENST00000464492.1_Silent_p.L108L|APOA2_ENST00000470459.2_Intron|APOA2_ENST00000491350.1_3'UTR|APOA2_ENST00000468465.1_Silent_p.L27L																							CCTTCTTGATCAGGGGTGTCA	0.507000													12	389					0	0	1	0	0
TMPRSS11F	389208	broad.mit.edu	37	4	68919643	68919643	+	Nonsense_Mutation	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr4:68919643G>C	ENST00000356291.2	-	10	1360	c.1301C>G	c.(1300-1302)tCa>tGa	p.S434*	UBA6-AS1_ENST00000500538.2_RNA	NM_207407.2	NP_997290.2	Q6ZWK6	TM11F_HUMAN	transmembrane protease, serine 11F	434	Peptidase S1.				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(4)	39						ACCAGTCTTTGAGGCAATCCA	0.403000													6	44					0	0	1	0	0
GBA2	57704	broad.mit.edu	37	9	35738548	35738548	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr9:35738548C>T	ENST00000378094.4	-	13	2542	c.2029G>A	c.(2029-2031)Gat>Aat	p.D677N	GBA2_ENST00000378103.3_Missense_Mutation_p.D677N|GBA2_ENST00000545786.1_Missense_Mutation_p.D683N|GBA2_ENST00000467252.1_5'UTR|GBA2_ENST00000378088.1_5'UTR			Q9HCG7	GBA2_HUMAN	glucosidase, beta (bile acid) 2	677					bile acid metabolic process|glucosylceramide catabolic process|O-glycoside catabolic process	integral to membrane|microsome|plasma membrane|smooth endoplasmic reticulum	beta-glucosidase activity|glucosylceramidase activity			NS(1)|kidney(3)|large_intestine(5)|lung(5)|ovary(4)|skin(3)	21	all_epithelial(49;0.167)		Lung(28;0.00416)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			ACCCATCCATCATAGGTCTGG	0.507000													16	63					0	0	1	0	0
OR5H15	403274	broad.mit.edu	37	3	97888417	97888417	+	Silent	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr3:97888417C>T	ENST00000356526.2	+	1	874	c.874C>T	c.(874-876)Ctg>Ttg	p.L292L		NM_001005515.1	NP_001005515.1	A6NDH6	O5H15_HUMAN	olfactory receptor, family 5, subfamily H, member 15	292					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(20)|ovary(1)|prostate(1)|skin(2)|stomach(1)	35						CATCTACAGTCTGAGAAATAA	0.338000													10	49					0	0	1	0	0
UTP6	55813	broad.mit.edu	37	17	30214281	30214281	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr17:30214281C>T	ENST00000261708.4	-	8	732	c.595G>A	c.(595-597)Gaa>Aaa	p.E199K	UTP6_ENST00000490218.2_5'UTR	NM_018428.2	NP_060898.2	Q9NYH9	UTP6_HUMAN	UTP6, small subunit (SSU) processome component, homolog (yeast)	199					rRNA processing	nucleolus	binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|skin(1)	21		all_hematologic(16;0.0149)|Ovarian(249;0.021)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|Breast(31;0.231)				TTTTCAAATTCTTCCTTCTCC	0.343000													7	34					0	0	1	0	0
RAPH1	65059	broad.mit.edu	37	2	204354651	204354651	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr2:204354651G>A	ENST00000319170.5	-	4	687	c.388C>T	c.(388-390)Cat>Tat	p.H130Y	RAPH1_ENST00000423104.1_Missense_Mutation_p.H130Y|RAPH1_ENST00000374493.3_Missense_Mutation_p.H130Y|RAPH1_ENST00000374489.2_Missense_Mutation_p.H130Y|RAPH1_ENST00000308091.4_Missense_Mutation_p.H130Y|RAPH1_ENST00000418114.1_Missense_Mutation_p.H130Y|RAPH1_ENST00000457812.1_Missense_Mutation_p.H130Y|RAPH1_ENST00000439222.1_Missense_Mutation_p.H130Y|RAPH1_ENST00000419464.1_Missense_Mutation_p.H130Y|RAPH1_ENST00000374488.2_Missense_Mutation_p.H130Y|RAPH1_ENST00000453034.1_Missense_Mutation_p.H130Y	NM_213589.1	NP_998754.1	Q70E73	RAPH1_HUMAN	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	130					cell-matrix adhesion|signal transduction	cytoplasm|cytoskeleton|filopodium|lamellipodium|nucleus|plasma membrane				breast(5)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						AAGGTGCCATGTTTCAATGTA	0.453000													35	91					0	0	1	0	0
RORC	6097	broad.mit.edu	37	1	151779987	151779987	+	Missense_Mutation	SNP	G	G	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:151779987G>T	ENST00000356728.6	-	10	1609	c.1455C>A	c.(1453-1455)ttC>ttA	p.F485L	RORC_ENST00000392697.3_Missense_Mutation_p.F560L|RORC_ENST00000318247.6_Missense_Mutation_p.F506L|RORC_ENST00000480719.1_5'UTR	NM_001001523.1	NP_001001523.1	P51449	RORG_HUMAN	RAR-related orphan receptor C	506	Ligand-binding.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|large_intestine(1)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			TTTCAGTGCTGAAGAGCTCCT	0.607000													5	34					0.217242	0.218622	1	1	0
SPAST	6683	broad.mit.edu	37	2	32352058	32352058	+	Silent	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr2:32352058C>G	ENST00000315285.3	+	8	1265	c.1140C>G	c.(1138-1140)ctC>ctG	p.L380L	SPAST_ENST00000345662.1_Silent_p.L348L	NM_014946.3	NP_055761.2	Q9UBP0	SPAST_HUMAN	spastin	380	Sufficient for microtubule severing.				cell cycle|cell death|cell differentiation|cytokinesis, completion of separation|ER to Golgi vesicle-mediated transport|microtubule bundle formation|microtubule severing|nervous system development|protein hexamerization|protein homooligomerization	endoplasmic reticulum|endosome|integral to membrane|microtubule|microtubule organizing center|nucleus|perinuclear region of cytoplasm|spindle	alpha-tubulin binding|ATP binding|beta-tubulin binding|microtubule binding|microtubule-severing ATPase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(8)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					GGCTGTTACTCTTTGGTCCAC	0.358000													16	48					0	0	1	0	0
DPH7	92715	broad.mit.edu	37	9	140458893	140458893	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr9:140458893C>G	ENST00000277540.2	-	8	1099	c.942G>C	c.(940-942)aaG>aaC	p.K314N	DPH7_ENST00000479650.1_5'UTR	NM_138778.2	NP_620133.1			diphthamide biosynthesis 7																		CACCCATTGCCTTTTGGCAGT	0.632000													4	22					0	0	1	0	0
FAM208B	54906	broad.mit.edu	37	10	5773097	5773097	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr10:5773097G>C	ENST00000328090.5	+	11	1760	c.1135G>C	c.(1135-1137)Gac>Cac	p.D379H	RP11-336A10.2_ENST00000411512.2_RNA	NM_017782.4	NP_060252	Q5VWN6	CJ018_HUMAN	family with sequence similarity 208, member B	379																	TTCCAGAGCAGACAACAGCTC	0.453000													7	86					0	0	1	0	0
PTGDR	5729	broad.mit.edu	37	14	52741532	52741532	+	Silent	SNP	A	A	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr14:52741532A>G	ENST00000306051.2	+	2	1032	c.930A>G	c.(928-930)cgA>cgG	p.R310R	PTGDR_ENST00000553372.1_3'UTR	NM_000953.2	NP_000944.1	Q13258	PD2R_HUMAN	prostaglandin D2 receptor (DP)	310						integral to membrane|plasma membrane	prostaglandin D receptor activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(15)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Breast(41;0.0639)|all_epithelial(31;0.0887)				Nedocromil(DB00716)	GAGCCTTGCGATTTCTATCTG	0.378000													7	47					0	0	1	0	0
RUNX2	860	broad.mit.edu	37	6	45399754	45399754	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr6:45399754G>A	ENST00000371438.1	+	3	936	c.578G>A	c.(577-579)cGa>cAa	p.R193Q	RUNX2_ENST00000371436.6_Missense_Mutation_p.R193Q|RUNX2_ENST00000541979.1_Missense_Mutation_p.R261Q|RUNX2_ENST00000371432.3_Missense_Mutation_p.R179Q|RUNX2_ENST00000465038.2_Missense_Mutation_p.R193Q|RUNX2_ENST00000352853.5_Missense_Mutation_p.R261Q|RUNX2_ENST00000576263.1_Missense_Mutation_p.R193Q|RUNX2_ENST00000359524.5_Missense_Mutation_p.R179Q	NM_001024630.3	NP_001019801.3	Q13950	RUNX2_HUMAN	runt-related transcription factor 2	193	Runt.		R -> C (in CLCD).|R -> Q (in CLCD).		negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(18)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						CGGAGTGGACGAGGTAGGTCT	0.408000													4	18					0	0	1	0	0
CDH22	64405	broad.mit.edu	37	20	44845629	44845629	+	Missense_Mutation	SNP	A	A	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr20:44845629A>G	ENST00000372262.3	-	4	1074	c.674T>C	c.(673-675)gTa>gCa	p.V225A	CDH22_ENST00000474438.1_5'UTR|CDH22_ENST00000537909.1_Missense_Mutation_p.V225A	NM_021248.1	NP_067071.1	Q9UJ99	CAD22_HUMAN	cadherin 22, type 2	225	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	44		Myeloproliferative disorder(115;0.0122)				CGTCCGGATTACGCCTGTGGG	0.652000													19	46					0	0	1	0	0
PRKG1	5592	broad.mit.edu	37	10	54031249	54031249	+	Splice_Site	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr10:54031249G>A	ENST00000373980.4	+	11	1730	c.1313G>A	c.(1312-1314)aGa>aAa	p.R438K	PRKG1_ENST00000373975.2_Splice_Site_p.R141K|PRKG1_ENST00000373985.1_Splice_Site_p.R411K|PRKG1-AS1_ENST00000452247.2_RNA|PRKG1-AS1_ENST00000426785.2_RNA|PRKG1_ENST00000401604.2_Splice_Site_p.R423K	NM_006258.3	NP_006249.1	Q13976	KGP1_HUMAN	protein kinase, cGMP-dependent, type I	423	Protein kinase.				actin cytoskeleton organization|platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(23)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	53		all_cancers(4;2.13e-08)|all_epithelial(4;2.44e-08)|all_lung(4;0.000173)		all cancers(4;1.18e-05)|GBM - Glioblastoma multiforme(4;0.000359)|Epithelial(53;0.00532)|Lung(62;0.0606)		TTCATAGTGAGGTAAAGGCTC	0.488000													4	19					0	0	1	0	0
ITGB8	3696	broad.mit.edu	37	7	20441589	20441589	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr7:20441589G>C	ENST00000222573.4	+	10	2211	c.1527G>C	c.(1525-1527)gaG>gaC	p.E509D	ITGB8_ENST00000537992.1_Missense_Mutation_p.E374D	NM_002214.2	NP_002205.1	P26012	ITB8_HUMAN	integrin, beta 8		Cysteine-rich tandem repeats.				cell-matrix adhesion|integrin-mediated signaling pathway|placenta blood vessel development	integrin complex	protein binding|receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(17)|prostate(2)|skin(4)|stomach(2)|urinary_tract(1)	37						TTTCTTCTGAGAGTTGCAAGT	0.383000													38	115					0	0	1	0	0
ZBP1	81030	broad.mit.edu	37	20	56191385	56191385	+	Silent	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr20:56191385G>C	ENST00000340462.4	-	2	454	c.174C>G	c.(172-174)gtC>gtG	p.V58V	ZBP1_ENST00000541799.1_Silent_p.V58V|ZBP1_ENST00000395822.3_Intron|ZBP1_ENST00000343535.4_Silent_p.V58V|ZBP1_ENST00000371173.3_Silent_p.V58V|ZBP1_ENST00000538947.1_5'UTR			Q9H171	ZBP1_HUMAN	Z-DNA binding protein 1	58						cytoplasm|nucleus	double-stranded RNA adenosine deaminase activity|left-handed Z-DNA binding|RNA binding			large_intestine(11)|lung(8)|ovary(4)|prostate(1)|skin(2)|urinary_tract(1)	27	Lung NSC(12;0.000545)|all_lung(29;0.00195)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;7.87e-13)|Epithelial(14;3.26e-09)|all cancers(14;3.62e-08)			ATGTGAGGGAGACTTTCAACT	0.597000													4	138					0	0	1	0	0
FRG1B	284802	broad.mit.edu	37	20	29625877	29625877	+	Missense_Mutation	SNP	G	G	A	rs7266938	by1000genomes	TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr20:29625877G>A	ENST00000278882.3	+	5	501	c.121G>A	c.(121-123)Gcc>Acc	p.A41T	FRG1B_ENST00000439954.2_Missense_Mutation_p.A46T|FRG1B_ENST00000358464.4_Missense_Mutation_p.A41T														p.A41T(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GTACAGAATCGCCCTGAAATC	0.358000													5	51					0	0	1	0	0
ACSM4	341392	broad.mit.edu	37	12	7473374	7473374	+	Silent	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr12:7473374G>A	ENST00000399422.4	+	6	1023	c.975G>A	c.(973-975)cgG>cgA	p.R325R		NM_001080454.1	NP_001073923.1	P0C7M7	ACSM4_HUMAN	acyl-CoA synthetase medium-chain family member 4	325					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			endometrium(6)|kidney(1)|lung(14)	21						CTGTGTACCGGATGCTCGTGC	0.458000													4	29					0	0	1	0	0
BPTF	2186	broad.mit.edu	37	17	65907442	65907442	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr17:65907442C>T	ENST00000321892.4	+	13	3881	c.3820C>T	c.(3820-3822)Ctt>Ttt	p.L1274F	BPTF_ENST00000335221.5_Missense_Mutation_p.L1274F|BPTF_ENST00000306378.6_Missense_Mutation_p.L1148F|BPTF_ENST00000424123.3_Missense_Mutation_p.L1135F			Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	1274					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(23)|ovary(3)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	78	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			TTCCTCAGTTCTTAGAATGAG	0.413000													5	40					0	0	1	0	0
KRIT1	889	broad.mit.edu	37	7	91842710	91842710	+	Silent	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr7:91842710G>C	ENST00000394507.1	-	18	2607	c.1824C>G	c.(1822-1824)ctC>ctG	p.L608L	KRIT1_ENST00000412043.2_Silent_p.L608L|KRIT1_ENST00000394505.2_Silent_p.L608L|KRIT1_ENST00000340022.2_Silent_p.L608L|KRIT1_ENST00000394503.2_Silent_p.L560L	NM_194456.1	NP_919438.1	O00522	KRIT1_HUMAN	KRIT1, ankyrin repeat containing	608	FERM.|Required for RAP1A binding.				angiogenesis|cell redox homeostasis|negative regulation of angiogenesis|negative regulation of endothelial cell apoptosis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|regulation of establishment of cell polarity|small GTPase mediated signal transduction	cell-cell junction|cytoskeleton	protein binding|small GTPase regulator activity			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(9)|ovary(2)|stomach(1)	22	all_cancers(62;1.04e-09)|all_epithelial(64;5.75e-09)|Breast(17;0.00206)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			CACTTGTACTGAGATTCTAAA	0.328000													8	30					0	0	1	0	0
LAX1	54900	broad.mit.edu	37	1	203743121	203743121	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:203743121C>T	ENST00000442561.2	+	5	899	c.509C>T	c.(508-510)tCg>tTg	p.S170L	LAX1_ENST00000367217.5_Missense_Mutation_p.S154L|LAX1_ENST00000367215.1_3'UTR	NM_017773.3	NP_060243.2	Q8IWV1	LAX1_HUMAN	lymphocyte transmembrane adaptor 1	170					B cell activation|immune response|inactivation of MAPK activity|intracellular signal transduction|negative regulation of T cell activation	Golgi apparatus|integral to membrane|plasma membrane	protein kinase binding|SH2 domain binding	p.S170L(1)		central_nervous_system(2)|endometrium(3)|large_intestine(2)|lung(13)|prostate(1)|stomach(1)|urinary_tract(2)	24	all_cancers(21;0.0915)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CTCACTCCCTCGGCACACTGC	0.532000													7	59					0	0	1	0	0
C6orf195	154386	broad.mit.edu	37	6	2623984	2623984	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr6:2623984C>T	ENST00000296847.3	-	3	596	c.73G>A	c.(73-75)Gag>Aag	p.E25K		NM_152554.2	NP_689767.2	Q96MT4	CF195_HUMAN	chromosome 6 open reading frame 195	25										cervix(1)|endometrium(1)|lung(2)|skin(1)	5	Ovarian(93;0.0412)	all_hematologic(90;0.0895)				CTTTCTCCCTCGGGAGACAGG	0.562000													4	31					0	0	1	0	0
ELMOD2	255520	broad.mit.edu	37	4	141456971	141456971	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr4:141456971G>C	ENST00000323570.3	+	4	388	c.256G>C	c.(256-258)Gag>Cag	p.E86Q		NM_153702.3	NP_714913.1	Q8IZ81	ELMD2_HUMAN	ELMO/CED-12 domain containing 2	86					phagocytosis|regulation of defense response to virus|response to virus	cytoskeleton	GTPase activator activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	7	all_hematologic(180;0.162)					TATTAACCCTGAGAAGGATGC	0.338000													7	22					0	0	1	0	0
NPR1	4881	broad.mit.edu	37	1	153654315	153654315	+	Splice_Site	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:153654315G>C	ENST00000368680.3	+	4	1643	c.1171G>C	c.(1171-1173)Ggt>Cgt	p.G391R		NM_000906.3	NP_000897.3	P16066	ANPRA_HUMAN	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	391					body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(17)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)	AAGCTTTCAAGGTCAGGGCCT	0.562000													3	37					0	0	1	0	0
CLTCL1	8218	broad.mit.edu	37	22	19188954	19188954	+	Silent	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr22:19188954G>C	ENST00000263200.10	-	23	3723	c.3651C>G	c.(3649-3651)ctC>ctG	p.L1217L	CLTCL1_ENST00000427926.1_Silent_p.L1217L|CLTCL1_ENST00000442042.2_5'UTR|CLTCL1_ENST00000353891.5_Silent_p.L1217L	NM_007098.3	NP_009029.3	P53675	CLH2_HUMAN	clathrin, heavy chain-like 1	1217	Heavy chain arm.|Involved in binding clathrin light chain (By similarity).|Proximal segment.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	Colorectal(54;0.0993)					CATTGCTATAGAGCAGCTTGG	0.537000			T	?	ALCL								4	38					0	0	1	0	0
PPP1R36	145376	broad.mit.edu	37	14	65055968	65055968	+	Missense_Mutation	SNP	C	C	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr14:65055968C>A	ENST00000298705.1	+	12	1277	c.1181C>A	c.(1180-1182)tCc>tAc	p.S394Y	RP11-973N13.3_ENST00000554454.1_RNA|RP11-973N13.3_ENST00000556634.1_RNA	NM_172365.1	NP_758953.1	Q96LQ0	CN050_HUMAN	protein phosphatase 1, regulatory subunit 36	394																	AGATATCCTTCCTTGATGGAA	0.438000													10	82					0.0931896	0.0943805	1	1	0
FBP1	2203	broad.mit.edu	37	9	97401532	97401532	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr9:97401532C>T	ENST00000415431.1	-	2	290	c.61G>A	c.(61-63)Gag>Aag	p.E21K	FBP1_ENST00000375326.4_Missense_Mutation_p.E21K	NM_001127628.1	NP_001121100.1	P09467	F16P1_HUMAN	fructose-1,6-bisphosphatase 1	21					gluconeogenesis	cytosol	fructose 1,6-bisphosphate 1-phosphatase activity|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding|metal ion binding			kidney(1)|liver(1)|lung(1)	3		Acute lymphoblastic leukemia(62;0.136)			Adenosine monophosphate(DB00131)	TTCCTGCCCTCCTCCATGACG	0.662000													3	6					0	0	1	0	0
TBC1D12	23232	broad.mit.edu	37	10	96162370	96162370	+	Translation_Start_Site	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr10:96162370G>A	ENST00000225235.4	+	0	110					NM_015188.1	NP_056003.1	O60347	TBC12_HUMAN	TBC1 domain family, member 12							intracellular	Rab GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|upper_aerodigestive_tract(2)	20		Colorectal(252;0.0429)				CCCACCCCCAGATGGTGGGTC	0.697000													8	17					0	0	1	0	0
GLTSCR1L	23506	broad.mit.edu	37	6	42832959	42832959	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr6:42832959G>C	ENST00000314073.5	+	13	3191	c.3015G>C	c.(3013-3015)aaG>aaC	p.K1005N	GLTSCR1L_ENST00000394168.1_Missense_Mutation_p.K1005N					GLTSCR1-like																		AGCTGACAAAGAGCTTGGAAA	0.488000													5	36					0	0	1	0	0
CLEC1A	51267	broad.mit.edu	37	12	10224041	10224041	+	Missense_Mutation	SNP	A	A	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr12:10224041A>G	ENST00000315330.4	-	6	796	c.734T>C	c.(733-735)tTc>tCc	p.F245S	CLEC1A_ENST00000457018.2_Missense_Mutation_p.F212S|CLEC1A_ENST00000420265.2_Missense_Mutation_p.F153S	NM_016511.2	NP_057595.2	Q8NC01	CLC1A_HUMAN	C-type lectin domain family 1, member A	245	C-type lectin.				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane|intracellular	sugar binding|transmembrane receptor activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(9)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)	23						GTCCTTTGAGAAGATCATCCC	0.443000													34	193					0	0	1	0	0
GON4L	54856	broad.mit.edu	37	1	155753858	155753858	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:155753858G>A	ENST00000437809.1	-	14	1933	c.1811C>T	c.(1810-1812)tCc>tTc	p.S604F	GON4L_ENST00000471341.1_5'UTR|GON4L_ENST00000368331.1_Missense_Mutation_p.S604F|GON4L_ENST00000361040.5_Missense_Mutation_p.S604F|GON4L_ENST00000271883.5_Missense_Mutation_p.S604F	NM_001282856.1	NP_001269785.1	Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	604					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					TTCCATGTTGGAGAATCCCAT	0.507000													8	104					0	0	1	0	0
ANKRD45	339416	broad.mit.edu	37	1	173628553	173628553	+	Missense_Mutation	SNP	T	T	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:173628553T>A	ENST00000333279.2	-	2	65	c.5A>T	c.(4-6)gAg>gTg	p.E2V		NM_198493.2	NP_940895.1	Q5TZF3	ANR45_HUMAN	ankyrin repeat domain 45	18										NS(2)|endometrium(2)|large_intestine(4)|lung(3)|skin(1)	12						TCCTTCTGACTCCATTAACTC	0.363000													20	45					0	0	1	0	0
MUC3A	4584	broad.mit.edu	37	7	100607832	100607832	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr7:100607832C>T	ENST00000319509.7	+	5	1979	c.1979C>T	c.(1978-1980)aCc>aTc	p.T660I	RP11-395B7.2_ENST00000434775.1_RNA|RP11-395B7.2_ENST00000420080.1_RNA					mucin 3A, cell surface associated									p.T660N(2)		breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(32)|prostate(3)	44						CAGGTGAAGACCACGCTGAAG	0.647000													5	54					0	0	1	0	0
WDFY3	23001	broad.mit.edu	37	4	85699717	85699717	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr4:85699717C>G	ENST00000322366.6	-	27	4864	c.4457G>C	c.(4456-4458)gGa>gCa	p.G1486A	WDFY3_ENST00000295888.4_Missense_Mutation_p.G1486A			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	1486						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		GGTCTCATGTCCACTATCAAC	0.368000													14	76					0	0	1	0	0
IQSEC2	23096	broad.mit.edu	37	X	53279469	53279469	+	Silent	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chrX:53279469G>C	ENST00000396435.3	-	5	2489	c.2289C>G	c.(2287-2289)ctC>ctG	p.L763L	IQSEC2_ENST00000375368.5_Silent_p.L753L|IQSEC2_ENST00000375365.2_Silent_p.L558L	NM_001111125.2	NP_001104595.1	Q5JU85	IQEC2_HUMAN	IQ motif and Sec7 domain 2	753	SEC7.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(10)|ovary(4)|skin(1)	29						ACTTGTTGAAGAGGTTGAGGC	0.572000													13	13					0	0	1	0	0
DTX3L	151636	broad.mit.edu	37	3	122289485	122289485	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr3:122289485C>T	ENST00000296161.4	+	4	2308	c.2119C>T	c.(2119-2121)Cac>Tac	p.H707Y	DTX3L_ENST00000383661.3_Missense_Mutation_p.H195Y	NM_138287.3	NP_612144.1	Q8TDB6	DTX3L_HUMAN	deltex 3-like (Drosophila)	707					histone monoubiquitination|response to DNA damage stimulus	cytoplasm|nucleus	histone binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	24				GBM - Glioblastoma multiforme(114;0.0459)		GAATGATATTCACCACAAAAC	0.418000													4	71					0	0	1	0	0
PC	5091	broad.mit.edu	37	11	66616455	66616455	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr11:66616455G>A	ENST00000393960.1	-	23	3733	c.3452C>T	c.(3451-3453)tCa>tTa	p.S1151L	PC_ENST00000393955.2_Missense_Mutation_p.S1151L|PC_ENST00000528224.1_5'UTR|PC_ENST00000393958.2_Missense_Mutation_p.S1151L|PC_ENST00000529047.1_Missense_Mutation_p.S271L	NM_001040716.1	NP_001035806.1	P11498	PYC_HUMAN	pyruvate carboxylase	1151	Biotinyl-binding.				gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	CTCCATGGGTGAGGTCACCAC	0.577000													14	42					0	0	1	0	0
FNBP1	23048	broad.mit.edu	37	9	132658177	132658177	+	Missense_Mutation	SNP	C	C	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr9:132658177C>A	ENST00000420781.1	-	16	1977	c.1759G>T	c.(1759-1761)Gat>Tat	p.D587Y	FNBP1_ENST00000443566.2_Missense_Mutation_p.D224Y|FNBP1_ENST00000355681.3_Missense_Mutation_p.D567Y|FNBP1_ENST00000446176.2_Missense_Mutation_p.D596Y			Q96RU3	FNBP1_HUMAN	formin binding protein 1	596	Interaction with ARHGAP17, DAAM1, DIAPH1 and DIAPH2.|Interaction with DNM1 and DNM3.|Interaction with DNM2 and WASL.|Interaction with FASLG.|Interaction with PDE6G (By similarity).|Required for interaction with TNKS.|Required for self-association and induction of membrane tubulation.|SH3.				endocytosis	cell cortex|cytoplasmic membrane-bounded vesicle|cytoskeleton|lysosome|plasma membrane	identical protein binding|lipid binding						Ovarian(14;0.000536)		GBM - Glioblastoma multiforme(294;0.0378)		CCCTCTTCATCTTCATTTCTC	0.393000			T	MLL	AML								10	32					4.68919e-08	5.09066e-08	1	1	0
DLG5	9231	broad.mit.edu	37	10	79628952	79628952	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr10:79628952G>C	ENST00000372391.2	-	2	313	c.308C>G	c.(307-309)tCt>tGt	p.S103C	DLG5_ENST00000372388.2_Missense_Mutation_p.S103C|AL391421.1_ENST00000372387.1_3'UTR	NM_004747.3	NP_004738.3	Q8TDM6	DLG5_HUMAN	discs, large homolog 5 (Drosophila)	103					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			breast(9)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(17)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	60	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			GCTGTAGGTAGAACCTGGGGA	0.582000													6	40					0	0	1	0	0
ATP13A1	57130	broad.mit.edu	37	19	19767686	19767686	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr19:19767686C>G	ENST00000357324.6	-	6	972	c.946G>C	c.(946-948)Gag>Cag	p.E316Q	ATP13A1_ENST00000291503.5_Missense_Mutation_p.E198Q	NM_020410.2	NP_065143.2	Q9HD20	AT131_HUMAN	ATPase type 13A1	316					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						GGTACGATCTCATCACTGGCA	0.662000													5	13					0	0	1	0	0
GABRB3	2562	broad.mit.edu	37	15	26825481	26825481	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr15:26825481C>T	ENST00000541819.2	-	7	937	c.835G>A	c.(835-837)Gtt>Att	p.V279I	GABRB3_ENST00000400188.3_Missense_Mutation_p.V152I|GABRB3_ENST00000299267.4_Missense_Mutation_p.V223I|GABRB3_ENST00000545868.1_Missense_Mutation_p.V138I|GABRB3_ENST00000311550.5_Missense_Mutation_p.V223I			P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 3	223					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity	p.V223F(2)|p.V279F(1)		NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(41)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	68		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	GCGAAGACAACATTCCTCGAG	0.557000													5	40					0	0	1	0	0
CTIF	9811	broad.mit.edu	37	18	46287796	46287796	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr18:46287796G>C	ENST00000256413.3	+	9	1402	c.1107G>C	c.(1105-1107)caG>caC	p.Q369H	CTIF_ENST00000382998.4_Missense_Mutation_p.Q371H	NM_014772.2	NP_055587.1	O43310	CTIF_HUMAN	CBP80/20-dependent translation initiation factor	369					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational initiation	perinuclear region of cytoplasm	protein binding	p.Q369H(1)		breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(14)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	31						CTCCCCAGCAGAACAAGATGG	0.577000													3	29					0	0	1	0	0
GRIA1	2890	broad.mit.edu	37	5	153056622	153056622	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr5:153056622G>C	ENST00000285900.5	+	7	1273	c.930G>C	c.(928-930)caG>caC	p.Q310H	GRIA1_ENST00000518142.1_Missense_Mutation_p.Q230H|GRIA1_ENST00000521843.2_Missense_Mutation_p.Q241H|GRIA1_ENST00000340592.5_Missense_Mutation_p.Q310H|GRIA1_ENST00000448073.4_Missense_Mutation_p.Q320H|GRIA1_ENST00000518783.1_Missense_Mutation_p.Q320H	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	310					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	TGCGGAGGCAGAGAATTGATA	0.567000													3	26					0	0	1	0	0
MFHAS1	9258	broad.mit.edu	37	8	8748927	8748927	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr8:8748927C>G	ENST00000276282.6	-	1	2228	c.1642G>C	c.(1642-1644)Gag>Cag	p.E548Q		NM_004225.2	NP_004216.2	Q9Y4C4	MFHA1_HUMAN	malignant fibrous histiocytoma amplified sequence 1	548	Roc.									endometrium(1)|kidney(3)|large_intestine(7)|lung(6)|ovary(1)|prostate(2)|stomach(1)	21		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.124)		CATTTCTCCTCCAGCTCACGC	0.662000													10	15					0	0	1	0	0
FAM124B	79843	broad.mit.edu	37	2	225265855	225265855	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr2:225265855C>T	ENST00000389874.3	-	1	856	c.631G>A	c.(631-633)Gag>Aag	p.E211K	FAM124B_ENST00000243806.2_Missense_Mutation_p.E211K|FAM124B_ENST00000409685.3_Missense_Mutation_p.E211K	NM_024785.2	NP_079061.2	Q9H5Z6	F124B_HUMAN	family with sequence similarity 124B	211							protein binding			endometrium(2)|large_intestine(2)|lung(7)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	16		Renal(207;0.0112)|all_lung(227;0.0126)|Lung NSC(271;0.0161)|all_hematologic(139;0.138)		Epithelial(121;4.4e-10)|all cancers(144;2.02e-07)|Lung(261;0.00766)|LUSC - Lung squamous cell carcinoma(224;0.00825)		TGGCCGATCTCTTGAACCTTA	0.547000													3	35					0	0	1	0	0
ATAD5	79915	broad.mit.edu	37	17	29161265	29161265	+	Missense_Mutation	SNP	C	C	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr17:29161265C>A	ENST00000321990.4	+	2	544	c.166C>A	c.(166-168)Cca>Aca	p.P56T		NM_024857.3	NP_079133.3	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	56					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(18)|lung(13)|ovary(3)|pancreas(1)	51		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				GGTTTTTGCTCCACCAAAACC	0.373000													6	39					3.59834e-05	3.81496e-05	1	1	0
ZMYM6	9204	broad.mit.edu	37	1	35480460	35480460	+	Silent	SNP	C	C	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:35480460C>A	ENST00000357182.4	-	6	860	c.633G>T	c.(631-633)gtG>gtT	p.V211V	ZMYM6_ENST00000487874.1_Silent_p.V211V|ZMYM6_ENST00000493328.1_5'UTR|ZMYM6_ENST00000373340.2_Silent_p.V211V	NM_007167.3	NP_009098.3	O95789	ZMYM6_HUMAN	zinc finger, MYM-type 6	211					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(10)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	44		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				GACCATGTACCACATTTTGAT	0.353000													7	40					2.7689e-08	3.01629e-08	1	1	0
ZNF782	158431	broad.mit.edu	37	9	99580848	99580848	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr9:99580848G>C	ENST00000481138.1	-	6	2118	c.1457C>G	c.(1456-1458)tCt>tGt	p.S486C	ZNF782_ENST00000535338.1_Missense_Mutation_p.S354C	NM_001001662.1	NP_001001662.1	Q6ZMW2	ZN782_HUMAN	zinc finger protein 782	486					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(8)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)	33		Acute lymphoblastic leukemia(62;0.0527)				ATGGCTGAAAGATTTCCCGCA	0.403000													25	160					0	0	1	0	0
LCLAT1	253558	broad.mit.edu	37	2	30756161	30756161	+	Silent	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr2:30756161C>G	ENST00000309052.4	+	4	668	c.459C>G	c.(457-459)ctC>ctG	p.L153L	LCLAT1_ENST00000319406.4_Silent_p.L153L|LCLAT1_ENST00000359433.1_Silent_p.L153L|LCLAT1_ENST00000491680.2_3'UTR|LCLAT1_ENST00000379509.3_Silent_p.L115L|LCLAT1_ENST00000540623.1_Silent_p.L115L	NM_182551.3	NP_872357.2	Q6UWP7	LCLT1_HUMAN	lysocardiolipin acyltransferase 1	153					multicellular organismal development|phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(6)|ovary(2)	19						AAGCGAGTCTCAAAGGTGTTC	0.393000													45	103					0	0	1	0	0
NHP2	55651	broad.mit.edu	37	5	177580526	177580526	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr5:177580526C>G	ENST00000274606.3	-	2	345	c.196G>C	c.(196-198)Gag>Cag	p.E66Q	NHP2_ENST00000314397.4_Missense_Mutation_p.E66Q	NM_017838.3	NP_060308.1	Q9NX24	NHP2_HUMAN	NHP2 ribonucleoprotein	66					rRNA pseudouridine synthesis	Cajal body|nucleolus|small nucleolar ribonucleoprotein complex	protein binding|snoRNA binding			endometrium(1)|kidney(1)|ovary(2)	4						TTCTGAACCTCTTTCACCCCG	0.527000													13	125					0	0	1	0	0
SLC15A4	121260	broad.mit.edu	37	12	129293983	129293983	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr12:129293983C>G	ENST00000266771.5	-	4	1086	c.1047G>C	c.(1045-1047)ttG>ttC	p.L349F	SLC15A4_ENST00000539703.1_5'UTR|SLC15A4_ENST00000544112.1_Missense_Mutation_p.L12F	NM_145648.3	NP_663623.1	Q8N697	S15A4_HUMAN	solute carrier family 15 (oligopeptide transporter), member 4	349					oligopeptide transport|protein transport	integral to membrane|lysosomal membrane	peptide:hydrogen symporter activity			endometrium(4)|kidney(2)|large_intestine(4)|lung(11)|skin(1)	22	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.69e-06)|Epithelial(86;1.17e-05)|all cancers(50;5.07e-05)		CTGGAATCCTCAAATGAAGAC	0.333000													6	95					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152755013	152755013	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr6:152755013C>T	ENST00000367255.5	-	34	4979	c.4378G>A	c.(4378-4380)Gtc>Atc	p.V1460I	SYNE1_ENST00000265368.4_Missense_Mutation_p.V1460I|SYNE1_ENST00000423061.1_Missense_Mutation_p.V1467I|SYNE1_ENST00000367248.3_3'UTR|SYNE1_ENST00000448038.1_Missense_Mutation_p.V1467I|SYNE1_ENST00000367253.4_Missense_Mutation_p.V1460I|SYNE1_ENST00000341594.5_Missense_Mutation_p.V1530I	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1460					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GTTATCCAGACGGACAGAGTC	0.368000										HNSCC(10;0.0054)			5	54					0	0	1	0	0
PRG4	10216	broad.mit.edu	37	1	186269244	186269244	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:186269244G>A	ENST00000445192.2	+	3	143	c.98G>A	c.(97-99)aGa>aAa	p.R33K	PRG4_ENST00000367485.4_Missense_Mutation_p.R33K|PRG4_ENST00000367483.4_Intron|PRG4_ENST00000367486.3_Missense_Mutation_p.R33K|PRG4_ENST00000367484.3_Intron	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	33	SMB 1.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						TGTGCAGGGAGATGTGGGGAA	0.448000													17	121					0	0	1	0	0
PPP1R36	145376	broad.mit.edu	37	14	65055919	65055919	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr14:65055919C>T	ENST00000298705.1	+	12	1228	c.1132C>T	c.(1132-1134)Cac>Tac	p.H378Y	RP11-973N13.3_ENST00000554454.1_RNA|RP11-973N13.3_ENST00000556634.1_RNA	NM_172365.1	NP_758953.1	Q96LQ0	CN050_HUMAN	protein phosphatase 1, regulatory subunit 36	378																	ACATACGCTTCACCCCCTTGA	0.438000													12	70					0	0	1	0	0
PRL	5617	broad.mit.edu	37	6	22294697	22294697	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr6:22294697G>A	ENST00000306482.1	-	2	663	c.145C>T	c.(145-147)Cgc>Tgc	p.R49C	RP3-404K8.2_ENST00000561912.1_RNA	NM_000948.5|NM_001163558.2	NP_000939.1|NP_001157030.1	P01236	PRL_HUMAN	prolactin	49					cell proliferation|cell surface receptor linked signaling pathway|female pregnancy|lactation|positive regulation of JAK-STAT cascade|regulation of multicellular organism growth	cytosol|extracellular region	hormone activity|prolactin receptor binding			NS(1)|endometrium(2)|large_intestine(6)|lung(6)|prostate(1)	16	Ovarian(93;0.163)					ACGACGGCGCGGTCAAACAGG	0.597000													8	36					0	0	1	0	0
STAMBP	10617	broad.mit.edu	37	2	74076511	74076511	+	Missense_Mutation	SNP	G	G	A	rs146601260	byFrequency	TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr2:74076511G>A	ENST00000394070.2	+	6	1267	c.764G>A	c.(763-765)cGc>cAc	p.R255H	STAMBP_ENST00000339566.3_Missense_Mutation_p.R255H|STAMBP_ENST00000409707.1_Missense_Mutation_p.R255H|STAMBP_ENST00000394073.1_Missense_Mutation_p.R255H|STAMBP_ENST00000536064.1_Missense_Mutation_p.A195T	NM_213622.2	NP_998787.1	O95630	STABP_HUMAN	STAM binding protein	255	MPN.				JAK-STAT cascade|positive regulation of cell proliferation	early endosome|membrane|nucleus	metal ion binding|metallopeptidase activity|protein binding	p.R255H(1)		NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	18						GATGGATTGCGCCATGTGGTG	0.567000													8	72					0	0	1	0	0
CASQ2	845	broad.mit.edu	37	1	116244023	116244023	+	Missense_Mutation	SNP	G	G	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:116244023G>T	ENST00000261448.5	-	11	1278	c.1039C>A	c.(1039-1041)Cca>Aca	p.P347T	CASQ2_ENST00000456138.2_Missense_Mutation_p.P276T	NM_001232.3	NP_001223.2	O14958	CASQ2_HUMAN	calsequestrin 2 (cardiac muscle)	347					heart development|striated muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|skin(1)	18	Lung SC(450;0.211)	all_cancers(81;1.25e-06)|all_epithelial(167;1.02e-06)|all_lung(203;8.03e-06)|Lung NSC(69;5.01e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		TCATCATCTGGAATCTCCATC	0.473000													6	63					0.00198382	0.00202861	1	1	0
LRP1	4035	broad.mit.edu	37	12	57552204	57552204	+	Silent	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr12:57552204C>T	ENST00000243077.3	+	11	2047	c.1581C>T	c.(1579-1581)ttC>ttT	p.F527F		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	527					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	ATGAGCTGTTCCTCGTGTATG	0.607000													4	37					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62298416	62298416	+	Nonsense_Mutation	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr11:62298416G>C	ENST00000378024.4	-	5	3747	c.3473C>G	c.(3472-3474)tCa>tGa	p.S1158*	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	1158					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				CTTGGGTCCTGAGACAACAAC	0.517000													62	142					0	0	1	0	0
TBX22	50945	broad.mit.edu	37	X	79282269	79282269	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chrX:79282269G>C	ENST00000442340.1	+	6	830	c.340G>C	c.(340-342)Gac>Cac	p.D114H	TBX22_ENST00000373296.3_Missense_Mutation_p.D234H|TBX22_ENST00000373294.5_Missense_Mutation_p.D234H|TBX22_ENST00000373291.1_Missense_Mutation_p.D114H	NM_001109878.1|NM_001109879.1	NP_001103348.1|NP_001103349.1	Q9Y458	TBX22_HUMAN	T-box 22	234					multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(13)|lung(38)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						CAGCAGTGTTGACCTGTCCCA	0.443000													22	17					0	0	1	0	0
NLRP6	171389	broad.mit.edu	37	11	281565	281565	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr11:281565G>A	ENST00000534750.1	+	4	2036	c.1831G>A	c.(1831-1833)Gag>Aag	p.E611K	NLRP6_ENST00000312165.5_Missense_Mutation_p.E611K	NM_001276700.1	NP_001263629.1	P59044	NALP6_HUMAN	NLR family, pyrin domain containing 6	611	Poly-Glu.					cytoplasm	ATP binding			breast(1)|skin(1)|upper_aerodigestive_tract(2)	4		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.28e-28)|Epithelial(43;2.47e-27)|OV - Ovarian serous cystadenocarcinoma(40;4.66e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.0485)|LUSC - Lung squamous cell carcinoma(625;0.122)		GGAGGAGGAGGAGGGAGAGGA	0.662000													17	49					0	0	1	0	0
TMEM131	23505	broad.mit.edu	37	2	98418970	98418970	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr2:98418970C>G	ENST00000186436.5	-	24	2800	c.2572G>C	c.(2572-2574)Gat>Cat	p.D858H		NM_015348.1	NP_056163.1	Q92545	TM131_HUMAN	transmembrane protein 131	858						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(4)|prostate(1)|skin(1)|stomach(1)	57						ACAGGAACATCTGCAGGATTT	0.299000													13	25					0	0	1	0	0
HLA-DQB2	3120	broad.mit.edu	37	6	32726682	32726682	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr6:32726682G>C	ENST00000435145.2	-	3	652	c.591C>G	c.(589-591)atC>atG	p.I197M	HLA-DQB2_ENST00000411527.1_Missense_Mutation_p.I197M|HLA-DQB2_ENST00000437316.2_Missense_Mutation_p.I197M			Q5SR06	Q5SR06_HUMAN	major histocompatibility complex, class II, DQ beta 2	197					antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|immune response	integral to membrane|MHC class II protein complex				endometrium(1)|kidney(1)|lung(1)|prostate(2)	5						GGCAGGTGTAGATGTCTCCAC	0.557000													3	21					0	0	1	0	0
PARP2	10038	broad.mit.edu	37	14	20819242	20819242	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr14:20819242C>T	ENST00000527915.1	+	6	502	c.497C>T	c.(496-498)tCa>tTa	p.S166L	PARP2_ENST00000429687.3_Missense_Mutation_p.S153L|PARP2_ENST00000250416.5_Missense_Mutation_p.S166L			Q9UGN5	PARP2_HUMAN	poly (ADP-ribose) polymerase 2	166					protein ADP-ribosylation	nucleolus|nucleoplasm	DNA binding|NAD+ ADP-ribosyltransferase activity			central_nervous_system(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|pancreas(1)	15	all_cancers(95;0.00092)	all_lung(585;0.235)	Epithelial(56;5.34e-07)|all cancers(55;3.7e-06)	GBM - Glioblastoma multiforme(265;0.00888)|READ - Rectum adenocarcinoma(17;0.0649)		GTGGCTTGTTCAGGCAATCTC	0.428000								Poly(ADP-ribose) polymerase (PARP) enzymes that bind to DNA					4	26					0	0	1	0	0
ABO	28	broad.mit.edu	37	9	136131529	136131529	+	RNA	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr9:136131529C>T	ENST00000453660.2	-	0	599							P16442	BGAT_HUMAN	ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)						protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	fucosylgalactoside 3-alpha-galactosyltransferase activity|glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity|metal ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(2)|prostate(1)|stomach(2)	11				OV - Ovarian serous cystadenocarcinoma(145;5.82e-06)|Epithelial(140;3.45e-05)		AAGCGCCGCTCGCAGAAGTCA	0.647000													3	8					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53856730	53856730	+	Silent	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr19:53856730G>A	ENST00000458035.1	+	4	2919	c.2802G>A	c.(2800-2802)aaG>aaA	p.K934K	ZNF845_ENST00000595091.1_Silent_p.K934K	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	934					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.K934K(3)		endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						TAATTCATAAGACAATTCATA	0.368000													3	34					0	0	1	0	0
PAIP1	10605	broad.mit.edu	37	5	43539109	43539109	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr5:43539109G>C	ENST00000306846.3	-	5	995	c.763C>G	c.(763-765)Caa>Gaa	p.Q255E	PAIP1_ENST00000436644.2_Missense_Mutation_p.Q176E|PAIP1_ENST00000514514.1_Missense_Mutation_p.Q176E|PAIP1_ENST00000338972.4_Missense_Mutation_p.Q143E	NM_006451.4|NM_182789.3	NP_006442.2|NP_877590.1	Q9H074	PAIP1_HUMAN	poly(A) binding protein interacting protein 1	255	MIF4G.				mRNA stabilization|nuclear-transcribed mRNA poly(A) tail shortening|translational initiation	cytosol	protein binding|RNA binding|translation activator activity			endometrium(2)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	Lung NSC(6;2.07e-05)					TTTGCAGCTTGATCTTTAACT	0.323000													20	105					0	0	1	0	0
CDON	50937	broad.mit.edu	37	11	125891340	125891340	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr11:125891340G>A	ENST00000392693.3	-	3	279	c.152C>T	c.(151-153)tCt>tTt	p.S51F	CDON_ENST00000263577.7_Missense_Mutation_p.S51F	NM_001243597.1|NM_016952.4	NP_001230526.1|NP_058648.4	Q4KMG0	CDON_HUMAN	cell adhesion associated, oncogene regulated	51	Ig-like C2-type 1.				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(9)|ovary(3)|prostate(2)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	61	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		AGGTTGAGCAGAACAATGCAG	0.453000													3	50					0	0	1	0	0
GJA9	81025	broad.mit.edu	37	1	39341511	39341511	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:39341511G>A	ENST00000454994.2	-	2	536	c.260C>T	c.(259-261)tCa>tTa	p.S87L	RP5-864K19.4_ENST00000433671.2_RNA|MYCBP_ENST00000489803.1_5'UTR|GJA9_ENST00000360786.3_Missense_Mutation_p.S87L|RP5-864K19.4_ENST00000443161.1_RNA|RP5-864K19.4_ENST00000456813.1_RNA|GJA9_ENST00000357771.3_Missense_Mutation_p.S87L			P57773	CXA9_HUMAN	gap junction protein, alpha 9, 59kDa	87					cell communication	connexon complex|integral to membrane		p.S87L(1)		breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;8.23e-17)			CAGGGATGGTGAAGACACAAA	0.473000													12	83					0	0	1	0	0
XRN1	54464	broad.mit.edu	37	3	142141711	142141711	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr3:142141711C>G	ENST00000264951.4	-	7	881	c.764G>C	c.(763-765)aGa>aCa	p.R255T	XRN1_ENST00000544157.1_Missense_Mutation_p.R45T|XRN1_ENST00000463916.1_Missense_Mutation_p.R255T|XRN1_ENST00000392981.2_Missense_Mutation_p.R255T	NM_019001.3	NP_061874.3	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1	255					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			NS(1)|breast(3)|endometrium(6)|kidney(12)|large_intestine(11)|liver(1)|lung(17)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	61						AATATACTCTCTCATTAAAGA	0.328000													8	87					0	0	1	0	0
PSMA4	5685	broad.mit.edu	37	15	78834558	78834558	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr15:78834558G>A	ENST00000044462.7	+	3	193	c.43G>A	c.(43-45)Gaa>Aaa	p.E15K	PSMA4_ENST00000559082.1_Missense_Mutation_p.E15K|PSMA4_ENST00000557929.1_3'UTR|PSMA4_ENST00000558341.1_Missense_Mutation_p.E15K|PSMA4_ENST00000558281.1_Missense_Mutation_p.E15K|PSMA4_ENST00000560217.1_Missense_Mutation_p.E15K|PSMA4_ENST00000413382.2_5'UTR	NM_002789.4	NP_002780.1	P25789	PSA4_HUMAN	proteasome (prosome, macropain) subunit, alpha type, 4	15					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	identical protein binding|threonine-type endopeptidase activity			kidney(2)|large_intestine(2)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	9						ATTTTCTCCAGAAGGTAAAAT	0.343000													3	53					0	0	1	0	0
WDR17	116966	broad.mit.edu	37	4	177093544	177093544	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr4:177093544G>C	ENST00000393643.2	+	25	3418	c.3166G>C	c.(3166-3168)Gaa>Caa	p.E1056Q	WDR17_ENST00000508596.1_Missense_Mutation_p.E1041Q|WDR17_ENST00000280190.4_Missense_Mutation_p.E1080Q|WDR17_ENST00000507824.2_Missense_Mutation_p.E1055Q	NM_170710.4	NP_733828.2	Q8IZU2	WDR17_HUMAN	WD repeat domain 17	1080										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(18)|lung(46)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	92		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		ACCCACAGTGGAAGAATGTAT	0.338000													6	46					0	0	1	0	0
PLEKHA6	22874	broad.mit.edu	37	1	204226675	204226675	+	Silent	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:204226675G>A	ENST00000272203.3	-	9	1646	c.1330C>T	c.(1330-1332)Ctg>Ttg	p.L444L	PLEKHA6_ENST00000414478.1_Silent_p.L464L	NM_014935.4	NP_055750.2	Q9Y2H5	PKHA6_HUMAN	pleckstrin homology domain containing, family A member 6	444										breast(2)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(3)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)			AGGCGGCGCAGGGAGCTAGAG	0.687000													7	20					0	0	1	0	0
DIP2A	23181	broad.mit.edu	37	21	47929218	47929218	+	Missense_Mutation	SNP	A	A	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr21:47929218A>G	ENST00000318711.7	+	7	1019	c.836A>G	c.(835-837)aAc>aGc	p.N279S	DIP2A_ENST00000400274.1_Missense_Mutation_p.N278S|DIP2A_ENST00000466639.1_Missense_Mutation_p.N235S|DIP2A_ENST00000417564.2_Missense_Mutation_p.N278S|DIP2A_ENST00000457905.3_Missense_Mutation_p.N278S|DIP2A_ENST00000427143.2_Missense_Mutation_p.N214S|DIP2A_ENST00000435722.3_Missense_Mutation_p.N278S	NM_001146116.1|NM_015151.3	NP_001139588.1|NP_055966.2	Q14689	DIP2A_HUMAN	DIP2 disco-interacting protein 2 homolog A (Drosophila)	278					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			cervix(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(22)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		CAGCTTCTGAACACCCTGAAG	0.498000													10	79					0	0	1	0	0
MPZ	4359	broad.mit.edu	37	1	161276239	161276239	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:161276239C>G	ENST00000533357.1	-	4	530	c.464G>C	c.(463-465)gGg>gCg	p.G155A	MPZ_ENST00000360451.6_Missense_Mutation_p.G165A|MPZ_ENST00000491222.2_5'UTR|MPZ_ENST00000526189.1_5'UTR|MPZ_ENST00000336559.4_Missense_Mutation_p.G155A	NM_000530.6	NP_000521.2	P25189	MYP0_HUMAN	myelin protein zero	155					synaptic transmission	integral to plasma membrane	structural molecule activity			central_nervous_system(1)|large_intestine(2)|lung(1)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	10	all_cancers(52;6.96e-17)|all_hematologic(112;0.093)	Breast(1374;0.181)	BRCA - Breast invasive adenocarcinoma(70;0.00376)			CAGAACGACCCCGTACCTAGT	0.592000													7	140					0	0	1	0	0
SUPT20H	55578	broad.mit.edu	37	13	37607661	37607661	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr13:37607661G>A	ENST00000360252.4	-	10	882	c.635C>T	c.(634-636)cCt>cTt	p.P212L	SUPT20H_ENST00000464744.1_Missense_Mutation_p.P212L|SUPT20H_ENST00000542180.1_Missense_Mutation_p.P199L|SUPT20H_ENST00000350612.6_Missense_Mutation_p.P211L|SUPT20H_ENST00000356185.3_Missense_Mutation_p.P212L|SUPT20H_ENST00000475892.1_Missense_Mutation_p.P211L	NM_001278481.1|NM_001278482.1|NM_017569.3	NP_001265410.1|NP_001265411.1|NP_060039.1			suppressor of Ty 20 homolog (S. cerevisiae)																		TGCTATAGAAGGATCAAGACA	0.433000													23	78					0	0	1	0	0
SLC9A1	6548	broad.mit.edu	37	1	27426986	27426986	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:27426986C>T	ENST00000263980.3	-	12	2835	c.2260G>A	c.(2260-2262)Gag>Aag	p.E754K	SLC9A1_ENST00000545949.1_Missense_Mutation_p.E415K	NM_003047.4	NP_003038.2	P19634	SL9A1_HUMAN	solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1	754					regulation of pH	integral to membrane	sodium:hydrogen antiporter activity			central_nervous_system(1)|cervix(3)|endometrium(3)|kidney(2)|large_intestine(4)|liver(1)|lung(7)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	27				UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;2.19e-50)|OV - Ovarian serous cystadenocarcinoma(117;1.8e-29)|Colorectal(126;7.61e-09)|COAD - Colon adenocarcinoma(152;9.32e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000521)|KIRC - Kidney renal clear cell carcinoma(1967;0.00079)|STAD - Stomach adenocarcinoma(196;0.00125)|READ - Rectum adenocarcinoma(331;0.046)	Amiloride(DB00594)	TCCTCGTCCTCCTCAGCCACC	0.622000													22	147					0	0	1	0	0
TAF5L	27097	broad.mit.edu	37	1	229738564	229738564	+	Missense_Mutation	SNP	T	T	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:229738564T>C	ENST00000366675.3	-	4	438	c.350A>G	c.(349-351)gAa>gGa	p.E117G	TAF5L_ENST00000366676.1_Missense_Mutation_p.E117G|TAF5L_ENST00000258281.2_Missense_Mutation_p.E117G	NM_001025247.1	NP_001020418.1	O75529	TAF5L_HUMAN	TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa	117					histone H3 acetylation|transcription from RNA polymerase II promoter	STAGA complex|transcription factor TFTC complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|lung(4)|ovary(1)	11	Breast(184;0.193)|Ovarian(103;0.249)	Prostate(94;0.167)				GTAAAAACTTTCCACTGTGCT	0.483000													5	69					0	0	1	0	0
ATP2A1	487	broad.mit.edu	37	16	28898592	28898592	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr16:28898592C>G	ENST00000395503.4	+	7	811	c.627C>G	c.(625-627)ttC>ttG	p.F209L	ATP2A1_ENST00000357084.3_Missense_Mutation_p.F209L|ATP2A1_ENST00000536376.1_Missense_Mutation_p.F84L	NM_004320.4	NP_004311.1	O14983	AT2A1_HUMAN	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	209					apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(10)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(2)	38						ACATGCTTTTCTCGGTGAGCA	0.567000													13	26					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072190	17072190	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr22:17072190C>T	ENST00000359963.3	-	1	1510	c.1251G>A	c.(1249-1251)atG>atA	p.M417I		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	417					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				TTGCCAAAGCCATTTCTGTGG	0.522000													18	27					0	0	1	0	0
FAM124B	79843	broad.mit.edu	37	2	225265853	225265853	+	Silent	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr2:225265853C>T	ENST00000389874.3	-	1	858	c.633G>A	c.(631-633)gaG>gaA	p.E211E	FAM124B_ENST00000243806.2_Silent_p.E211E|FAM124B_ENST00000409685.3_Silent_p.E211E	NM_024785.2	NP_079061.2	Q9H5Z6	F124B_HUMAN	family with sequence similarity 124B	211							protein binding			endometrium(2)|large_intestine(2)|lung(7)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	16		Renal(207;0.0112)|all_lung(227;0.0126)|Lung NSC(271;0.0161)|all_hematologic(139;0.138)		Epithelial(121;4.4e-10)|all cancers(144;2.02e-07)|Lung(261;0.00766)|LUSC - Lung squamous cell carcinoma(224;0.00825)		ACTGGCCGATCTCTTGAACCT	0.552000													3	36					0	0	1	0	0
PLOD3	8985	broad.mit.edu	37	7	100860029	100860029	+	Nonsense_Mutation	SNP	C	C	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr7:100860029C>A	ENST00000223127.3	-	2	546	c.148G>T	c.(148-150)Gag>Tag	p.E50*		NM_001084.4	NP_001075.1	O60568	PLOD3_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3	50					protein modification process	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(12)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	31	Lung NSC(181;0.168)|all_lung(186;0.215)				Succinic acid(DB00139)|Vitamin C(DB00126)	AGGTACCCCTCGGTTTCAGCT	0.612000													5	15					4.096e-09	4.49284e-09	1	1	0
C15orf53	400359	broad.mit.edu	37	15	38988888	38988888	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr15:38988888G>A	ENST00000318792.1	+	1	90	c.80G>A	c.(79-81)aGc>aAc	p.S27N		NM_207444.2	NP_997327.1	Q8NAA6	CO053_HUMAN	chromosome 15 open reading frame 53	27										endometrium(1)|large_intestine(1)|lung(2)|skin(1)|stomach(1)	6		all_cancers(109;1.75e-13)|all_epithelial(112;1.02e-11)|Lung NSC(122;1.9e-09)|all_lung(180;4.04e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)		GBM - Glioblastoma multiforme(113;8.39e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0321)		AGGCCAGGAAGCAAGGCTAAG	0.532000													10	70					0	0	1	0	0
C10orf12	26148	broad.mit.edu	37	10	98741997	98741997	+	Missense_Mutation	SNP	T	T	A	rs144337666	by1000genomes	TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr10:98741997T>A	ENST00000286067.2	+	1	957	c.850T>A	c.(850-852)Tgc>Agc	p.C284S		NM_015652.2	NP_056467.2	Q8N655	CJ012_HUMAN	chromosome 10 open reading frame 12	284										NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(3)|prostate(2)|skin(2)|stomach(4)	45		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		GCCTGAGGTTTGCCCCACAAA	0.542000													6	53					0	0	1	0	0
TMED6	146456	broad.mit.edu	37	16	69377325	69377325	+	Silent	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr16:69377325C>T	ENST00000288025.3	-	4	763	c.708G>A	c.(706-708)aaG>aaA	p.K236K	RP11-343C2.7_ENST00000564737.1_Intron|RP11-343C2.9_ENST00000563634.1_Intron	NM_144676.3	NP_653277.2	Q8WW62	TMED6_HUMAN	transmembrane emp24 protein transport domain containing 6	236					transport	endoplasmic reticulum membrane|integral to membrane				breast(1)|endometrium(2)|kidney(1)|lung(2)|ovary(1)|prostate(1)|stomach(1)	9						ATCTTGGCTTCTTTGTATCTG	0.423000													6	23					0	0	1	0	0
IGHV3-16	28447	broad.mit.edu	37	14	106621934	106621934	+	RNA	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr14:106621934C>T	ENST00000390604.2	-	0	384																											GGCTCTCCGTCTGTTCTTTTG	0.527000													16	119					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41004990	41004990	+	Silent	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr5:41004990C>G	ENST00000399564.4	-	36	4347	c.3897G>C	c.(3895-3897)ggG>ggC	p.G1299G	MROH2B_ENST00000506092.2_Silent_p.G854G	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		TTCGCAGATTCCCATGCTTCC	0.532000													12	53					0	0	1	0	0
MPL	4352	broad.mit.edu	37	1	43804263	43804263	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:43804263G>C	ENST00000372470.3	+	3	305	c.263G>C	c.(262-264)gGa>gCa	p.G88A	MPL_ENST00000413998.2_Missense_Mutation_p.G88A	NM_005373.2	NP_005364.1	P40238	TPOR_HUMAN	myeloproliferative leukemia virus oncogene	88					cell proliferation|platelet activation	integral to plasma membrane	cytokine receptor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(551)|large_intestine(3)|lung(7)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	567	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CCCCACTTTGGAACCCGATAC	0.577000			Mis		MPD	MPD	congenital amegakaryocytic thrombocytopenia						26	38					0	0	1	0	0
USP9X	8239	broad.mit.edu	37	X	41047252	41047252	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chrX:41047252G>C	ENST00000324545.8	+	25	4325	c.3692G>C	c.(3691-3693)aGa>aCa	p.R1231T	USP9X_ENST00000378308.2_Missense_Mutation_p.R1231T	NM_001039590.2|NM_001039591.2	NP_001034679.2|NP_001034680.2	Q93008	USP9X_HUMAN	ubiquitin specific peptidase 9, X-linked						BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(6)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(16)|lung(29)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87						CAGGCTTCAAGATATATGCCT	0.328000													9	11					0	0	1	0	0
SLIT1	6585	broad.mit.edu	37	10	98763895	98763895	+	Silent	SNP	C	C	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr10:98763895C>A	ENST00000266058.4	-	34	4040	c.3795G>T	c.(3793-3795)ggG>ggT	p.G1265G	SLIT1_ENST00000371070.4_Silent_p.G1265G|ARHGAP19-SLIT1_ENST00000453547.2_3'UTR	NM_003061.2	NP_003052.2	O75093	SLIT1_HUMAN	slit homolog 1 (Drosophila)	1265	Laminin G-like.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(37)|ovary(5)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	78		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		TCATGGGGCTCCCGCCATCAA	0.572000													25	179					8.58068e-18	9.54413e-18	1	1	0
RBBP8NL	140893	broad.mit.edu	37	20	60991266	60991266	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr20:60991266C>T	ENST00000252998.1	-	6	496	c.340G>A	c.(340-342)Gag>Aag	p.E114K		NM_080833.2	NP_543023.2			RBBP8 N-terminal like																		GTCTCGTTCTCTTCCTTCAGC	0.637000													3	26					0	0	1	0	0
WDFY3	23001	broad.mit.edu	37	4	85642618	85642618	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr4:85642618C>T	ENST00000322366.6	-	46	7905	c.7498G>A	c.(7498-7500)Gag>Aag	p.E2500K	WDFY3_ENST00000295888.4_Missense_Mutation_p.E2517K			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	2517						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TTCTCCTCCTCTTCTATGGAG	0.468000													15	105					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7576886	7576886	+	Silent	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr17:7576886C>T	ENST00000420246.2	-	9	1092	c.960G>A	c.(958-960)aaG>aaA	p.K320K	TP53_ENST00000413465.2_Intron|TP53_ENST00000359597.4_Silent_p.K320K|TP53_ENST00000455263.2_Silent_p.K320K|TP53_ENST00000269305.4_Silent_p.K320K|TP53_ENST00000445888.2_Silent_p.K320K	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	320	Interaction with CARM1.|Interaction with HIPK1 (By similarity).|Interaction with HIPK2.		K -> N (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.K320N(3)|p.P318fs*15(2)|p.P318fs*21(1)|p.S315fs*22(1)|p.?(1)|p.L308fs*15(1)|p.K320K(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCAGTGGTTTCTTCTTTGGCT	0.458000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			15	39					0	0	1	0	0
UNC5B	219699	broad.mit.edu	37	10	73050857	73050857	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr10:73050857G>A	ENST00000335350.6	+	9	1701	c.1285G>A	c.(1285-1287)Gca>Aca	p.A429T	UNC5B_ENST00000373192.4_Missense_Mutation_p.A418T	NM_170744.4	NP_734465.2	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B (C. elegans)	429					apoptosis|axon guidance|regulation of apoptosis	integral to membrane		p.A429T(2)		breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(4)|skin(4)	49						CTTTAAGACGGCAAGGCCCAG	0.597000													5	192					0	0	1	0	0
TXNRD1	7296	broad.mit.edu	37	12	104715064	104715064	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr12:104715064C>G	ENST00000526691.1	+	8	1347	c.891C>G	c.(889-891)atC>atG	p.I297M	TXNRD1_ENST00000542918.1_Missense_Mutation_p.I295M|TXNRD1_ENST00000388854.3_Missense_Mutation_p.I297M|TXNRD1_ENST00000503506.2_Missense_Mutation_p.I245M|TXNRD1_ENST00000526950.1_Missense_Mutation_p.I314M|TXNRD1_ENST00000429002.2_Missense_Mutation_p.I395M|TXNRD1_ENST00000354940.6_Missense_Mutation_p.I245M|TXNRD1_ENST00000397736.2_Missense_Mutation_p.I289M|TXNRD1_ENST00000540716.1_Missense_Mutation_p.I207M|TXNRD1_ENST00000427956.1_Missense_Mutation_p.I360M|TXNRD1_ENST00000526390.1_Missense_Mutation_p.I289M|TXNRD1_ENST00000529546.1_Missense_Mutation_p.I207M|TXNRD1_ENST00000525566.1_Missense_Mutation_p.I395M|TXNRD1_ENST00000524698.1_Missense_Mutation_p.I245M|TXNRD1_ENST00000378070.4_Missense_Mutation_p.I344M	NM_001261445.1|NM_003330.3	NP_001248374.1|NP_003321.3	Q16881	TRXR1_HUMAN	thioredoxin reductase 1	395					cell redox homeostasis|cellular lipid metabolic process|electron transport chain|nucleobase, nucleoside and nucleotide interconversion|signal transduction|transport	cytosol|nucleolus	electron carrier activity|flavin adenine dinucleotide binding|NADP binding|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(5)|skin(1)|stomach(1)|urinary_tract(1)	16						AACATGGCATCAAGTTTATAA	0.393000													12	40					0	0	1	0	0
CERK	64781	broad.mit.edu	37	22	47107008	47107008	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr22:47107008C>G	ENST00000216264.8	-	5	656	c.544G>C	c.(544-546)Gag>Cag	p.E182Q	CERK_ENST00000541677.1_Intron	NM_022766.5	NP_073603.2	Q8TCT0	CERK1_HUMAN	ceramide kinase	182	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|ceramide metabolic process	integral to membrane of membrane fraction|membrane|nucleus	ATP binding|ceramide kinase activity|diacylglycerol kinase activity|magnesium ion binding	p.E182K(1)		cervix(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(2)|skin(2)	20		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)|BRCA - Breast invasive adenocarcinoma(115;0.171)		ATGTTAATCTCATACAGAGTC	0.413000													10	57					0	0	1	0	0
POM121	9883	broad.mit.edu	37	7	72414028	72414028	+	Missense_Mutation	SNP	A	A	G	rs150250764	by1000genomes	TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr7:72414028A>G	ENST00000395270.1	+	14	3742	c.2701A>G	c.(2701-2703)Agc>Ggc	p.S901G	POM121_ENST00000358357.3_Missense_Mutation_p.S901G|POM121_ENST00000446813.1_Missense_Mutation_p.S901G|POM121_ENST00000434423.2_Missense_Mutation_p.S1166G|POM121_ENST00000257622.4_Missense_Mutation_p.S901G	NM_001257190.1	NP_001244119.1	Q96HA1	P121A_HUMAN	POM121 transmembrane nucleoporin	1166	Pore side (Potential).|Thr-rich.				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|breast(1)|endometrium(9)|kidney(4)|large_intestine(6)|lung(12)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Lung NSC(55;0.163)				CTTCAACGTGAGCAGCACAAC	0.622000													4	50					0	0	1	0	0
INVS	27130	broad.mit.edu	37	9	103060272	103060272	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr9:103060272C>T	ENST00000262457.2	+	16	3256	c.3071C>T	c.(3070-3072)tCt>tTt	p.S1024F	INVS_ENST00000541287.1_Missense_Mutation_p.S928F|INVS_ENST00000262456.2_Missense_Mutation_p.S854F	NM_014425.3	NP_055240.2	Q9Y283	INVS_HUMAN	inversin	1024					negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasm|membrane|microtubule|nucleus|spindle	calmodulin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(4)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31		Acute lymphoblastic leukemia(62;0.056)				AAAGCCTCTTCTGTGCTGCGT	0.453000													10	95					0	0	1	0	0
PMS2	5395	broad.mit.edu	37	7	6042261	6042261	+	Silent	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr7:6042261G>A	ENST00000265849.7	-	5	465	c.360C>T	c.(358-360)gtC>gtT	p.V120V	PMS2_ENST00000469652.1_Intron|PMS2_ENST00000441476.2_Silent_p.V14V|PMS2_ENST00000406569.3_Silent_p.V120V|PMS2_ENST00000382321.4_Silent_p.V120V	NM_000535.5	NP_000526	P54278	PMS2_HUMAN	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	120					mismatch repair|reciprocal meiotic recombination|somatic hypermutation of immunoglobulin genes	MutLalpha complex	ATP binding|ATPase activity|endonuclease activity|protein binding|single base insertion or deletion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(6)|kidney(2)|large_intestine(11)|lung(13)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;4.39e-15)		TAGAAATGGTGACATCGCTGT	0.483000			"""Mis, N, F"""			"""colorectal, endometrial, ovarian, medulloblastoma, glioma"""		Direct reversal of damage;Mismatch excision repair (MMR)	Turcot syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				12	124					0	0	1	0	0
OR10K1	391109	broad.mit.edu	37	1	158435712	158435712	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:158435712G>C	ENST00000289451.2	+	1	441	c.361G>C	c.(361-363)Gat>Cat	p.D121H		NM_001004473.1	NP_001004473.1	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K, member 1	121					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.D121N(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	27	all_hematologic(112;0.0378)					CATGGGCTATGATCGCTATAT	0.532000													49	104					0	0	1	0	0
DCK	1633	broad.mit.edu	37	4	71895096	71895096	+	Missense_Mutation	SNP	T	T	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr4:71895096T>A	ENST00000504952.1	+	8	1079	c.881T>A	c.(880-882)aTc>aAc	p.I294N	DCK_ENST00000504730.1_3'UTR|DCK_ENST00000286648.5_3'UTR			P27707	DCK_HUMAN	deoxycytidine kinase	0					purine base metabolic process|purine-containing compound salvage|pyrimidine base metabolic process|pyrimidine nucleoside salvage|pyrimidine nucleotide metabolic process	cytosol|nucleus	ATP binding|deoxycytidine kinase activity|drug binding|phosphotransferase activity, alcohol group as acceptor|protein homodimerization activity			endometrium(2)|large_intestine(3)|lung(3)|ovary(1)	9			Lung(101;0.235)		Cladribine(DB00242)|Clofarabine(DB00631)|Decitabine(DB01262)|Fludarabine(DB01073)|Gemcitabine(DB00441)|Pemetrexed(DB00642)|Zalcitabine(DB00943)	TACTTTGTGATCTTGCTGAAG	0.323000													6	40					0	0	1	0	0
SPCS2	9789	broad.mit.edu	37	11	74680674	74680674	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr11:74680674G>A	ENST00000263672.6	+	4	463	c.424G>A	c.(424-426)Gtg>Atg	p.V142M	SPCS2_ENST00000530257.1_Missense_Mutation_p.V73M|SPCS2_ENST00000528265.1_Intron|SPCS2_ENST00000526361.1_Intron	NM_014752.2	NP_055567.2	Q15005	SPCS2_HUMAN	signal peptidase complex subunit 2 homolog (S. cerevisiae)	142					energy reserve metabolic process|regulation of insulin secretion|signal peptide processing	integral to membrane|microsome|signal peptidase complex	peptidase activity			breast(1)	1						CATCTTTCTCGTGGCCCACAG	0.393000													26	72					0	0	1	0	0
HSPD1	3329	broad.mit.edu	37	2	198359446	198359446	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr2:198359446C>G	ENST00000388968.3	-	5	808	c.541G>C	c.(541-543)Gaa>Caa	p.E181Q	HSPD1_ENST00000345042.2_Missense_Mutation_p.E181Q	NM_002156.4	NP_002147.2	P10809	CH60_HUMAN	heat shock 60kDa protein 1 (chaperonin)	181					'de novo' protein folding|activation of caspase activity|B cell cytokine production|B cell proliferation|chaperone-mediated protein complex assembly|interspecies interaction between organisms|isotype switching to IgG isotypes|MyD88-dependent toll-like receptor signaling pathway|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of interferon-alpha production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of macrophage activation|positive regulation of T cell activation|positive regulation of T cell mediated immune response to tumor cell|protein maturation|protein refolding|protein stabilization|response to unfolded protein|T cell activation	cell surface|coated pit|coated vesicle|cytosol|early endosome|extracellular space|lipopolysaccharide receptor complex|mitochondrial inner membrane|mitochondrial matrix|stored secretory granule	ATP binding|ATPase activity|cell surface binding|chaperone binding|DNA replication origin binding|lipopolysaccharide binding|p53 binding|single-stranded DNA binding			NS(1)|breast(3)|endometrium(2)|large_intestine(3)|lung(7)|skin(1)	17			Epithelial(96;0.225)			TTGCCAATTTCTTTGTCTCCG	0.363000													10	34					0	0	1	0	0
SMU1	55234	broad.mit.edu	37	9	33047347	33047347	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr9:33047347G>C	ENST00000397149.3	-	12	1536	c.1486C>G	c.(1486-1488)Cag>Gag	p.Q496E	SMU1_ENST00000536631.1_Missense_Mutation_p.Q335E	NM_018225.2	NP_060695.2	Q2TAY7	SMU1_HUMAN	smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)	496						cytoplasm|nucleus				endometrium(2)|lung(4)|ovary(2)|prostate(1)	9			LUSC - Lung squamous cell carcinoma(29;0.0227)	GBM - Glioblastoma multiforme(74;0.11)		ATCAGGTTCTGATGAGGGTGA	0.403000													5	41					0	0	1	0	0
HTR3B	9177	broad.mit.edu	37	11	113802527	113802527	+	Missense_Mutation	SNP	G	G	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr11:113802527G>T	ENST00000260191.2	+	4	563	c.306G>T	c.(304-306)gaG>gaT	p.E102D	HTR3B_ENST00000537778.1_Missense_Mutation_p.E91D	NM_006028.4	NP_006019.1	O95264	5HT3B_HUMAN	5-hydroxytryptamine (serotonin) receptor 3B, ionotropic	102					synaptic transmission	integral to plasma membrane|postsynaptic membrane	serotonin receptor activity|serotonin-activated cation-selective channel activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(11)	20		all_cancers(61;6.81e-18)|all_epithelial(67;6.67e-11)|all_hematologic(158;4.67e-05)|Melanoma(852;0.000316)|Acute lymphoblastic leukemia(157;0.000976)|Breast(348;0.0101)|Prostate(24;0.0154)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.04e-06)|Epithelial(105;1.98e-05)|all cancers(92;0.000201)|OV - Ovarian serous cystadenocarcinoma(223;0.151)		TGTTTGATGAGATTAGAGAGA	0.413000													15	109					1.5739e-10	1.73238e-10	1	1	0
PRPF3	9129	broad.mit.edu	37	1	150307587	150307587	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:150307587G>C	ENST00000324862.6	+	7	1075	c.910G>C	c.(910-912)Gac>Cac	p.D304H	PRPF3_ENST00000543398.1_Missense_Mutation_p.D169H|PRPF3_ENST00000467329.1_3'UTR|PRPF3_ENST00000414970.2_Missense_Mutation_p.D255H	NM_004698.2	NP_004689.1	O43395	PRPF3_HUMAN	pre-mRNA processing factor 3	304					nuclear mRNA splicing, via spliceosome	Cajal body|cytoplasm|nuclear speck|spliceosomal complex	protein binding			breast(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Lung NSC(24;5.57e-29)|Breast(34;0.000844)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)	Colorectal(1306;0.0149)		GCCATCAGAAGACATGGAATC	0.463000													3	41					0	0	1	0	0
KLHL10	317719	broad.mit.edu	37	17	39994310	39994310	+	Silent	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr17:39994310C>T	ENST00000293303.4	+	1	279	c.126C>T	c.(124-126)gtC>gtT	p.V42V	KLHL10_ENST00000485613.1_3'UTR	NM_152467.3	NP_689680.2	Q6JEL2	KLH10_HUMAN	kelch-like family member 10	42	BTB.					cytoplasm				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	26		Breast(137;0.000162)				GCGACGTGGTCATCAAGGTCA	0.502000													5	47					0	0	1	0	0
KCNH3	23416	broad.mit.edu	37	12	49944005	49944005	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr12:49944005C>T	ENST00000257981.6	+	10	2071	c.1811C>T	c.(1810-1812)aCg>aTg	p.T604M		NM_012284.1	NP_036416.1	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 3	604					regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity			NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(20)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	36						GCCTTCTGCACGCCGGGCGAG	0.672000													5	25					0	0	1	0	0
SLX4	84464	broad.mit.edu	37	16	3640038	3640038	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr16:3640038G>C	ENST00000294008.3	-	12	4241	c.3601C>G	c.(3601-3603)Cag>Gag	p.Q1201E		NM_032444.2	NP_115820.2	Q8IY92	SLX4_HUMAN	SLX4 structure-specific endonuclease subunit	1201	Interaction with PLK1 and TERF2-TERF2IP.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding			breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	76						GAAGGTTCCTGATCTGCATCA	0.527000								Direct reversal of damage					17	90					0	0	1	0	0
MARCH10	162333	broad.mit.edu	37	17	60788643	60788643	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr17:60788643C>G	ENST00000544856.2	-	10	2652	c.2274G>C	c.(2272-2274)caG>caC	p.Q758H	RP11-156L14.1_ENST00000582564.1_RNA|RP11-156L14.1_ENST00000584597.1_RNA|MARCH10_ENST00000456609.2_Missense_Mutation_p.Q759H|MARCH10_ENST00000583600.1_Missense_Mutation_p.Q797H|RP11-156L14.1_ENST00000577270.1_RNA|MARCH10_ENST00000311269.5_Missense_Mutation_p.Q759H|RP11-156L14.1_ENST00000579201.1_RNA			Q8NA82	MARHA_HUMAN	membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase	759							ligase activity|zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|liver(1)|lung(15)	38						CTGCAAACCTCTGCTCATAGA	0.502000													12	215					0	0	1	0	0
RHOB	388	broad.mit.edu	37	2	20647530	20647530	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr2:20647530G>A	ENST00000272233.4	+	1	696	c.304G>A	c.(304-306)Gag>Aag	p.E102K		NM_004040.2	NP_004031.1	P62745	RHOB_HUMAN	ras homolog family member B	102					angiogenesis|axon guidance|cell adhesion|endosome to lysosome transport|negative regulation of cell cycle|platelet activation|positive regulation of angiogenesis|protein transport|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|transformed cell apoptosis	cytosol|late endosome membrane|nucleus|plasma membrane	GTP binding|GTPase activity|protein binding			breast(1)|kidney(1)|lung(2)|ovary(1)|urinary_tract(2)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)	all_epithelial(98;4.19e-09)|Lung NSC(108;0.00452)|Ovarian(717;0.0164)		OV - Ovarian serous cystadenocarcinoma(76;1.14e-22)|Epithelial(75;7.84e-19)		GTGGGTCCCCGAGGTGAAGCA	0.612000													42	99					0	0	1	0	0
BPIFB3	359710	broad.mit.edu	37	20	31643287	31643287	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr20:31643287C>G	ENST00000375494.3	+	1	58	c.58C>G	c.(58-60)Cca>Gca	p.P20A		NM_182658.1	NP_872599.1	P59826	LPLC3_HUMAN	BPI fold containing family B, member 3	20	Leu-rich.				innate immune response	cytoplasm|extracellular region	lipid binding|protein binding										CCTGGCGACTCCATGCCAGGA	0.617000													8	60					0	0	1	0	0
TAF11	6882	broad.mit.edu	37	6	34846442	34846442	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr6:34846442C>T	ENST00000361288.4	-	5	692	c.561G>A	c.(559-561)atG>atA	p.M187I	TAF11_ENST00000420584.2_Silent_p.*155*|UHRF1BP1_ENST00000452449.2_Intron	NM_005643.3	NP_005634.1	Q15544	TAF11_HUMAN	TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa	187					positive regulation by host of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	transcription factor TFIID complex	protein N-terminus binding|thyroid hormone receptor binding|transcription coactivator activity|vitamin D receptor binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(1)	6						CGGCTTCCCTCATATGTTTGG	0.408000													19	70					0	0	1	0	0
CR1	1378	broad.mit.edu	37	1	207782665	207782665	+	Missense_Mutation	SNP	C	C	G	rs117571325	by1000genomes	TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:207782665C>G	ENST00000367049.4	+	37	5927	c.5927C>G	c.(5926-5928)tCc>tGc	p.S1976C	CR1_ENST00000400960.2_Missense_Mutation_p.S1526C|CR1_ENST00000367052.1_Missense_Mutation_p.S1526C|CR1_ENST00000367051.1_Missense_Mutation_p.S1526C|CR1_ENST00000367053.1_Missense_Mutation_p.S1526C	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	1526					complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						CCAACCATATCCAATGGAGAC	0.373000													13	75					0	0	1	0	0
TBC1D32	221322	broad.mit.edu	37	6	121526278	121526278	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr6:121526278G>C	ENST00000275159.6	-	22	2512	c.2513C>G	c.(2512-2514)tCt>tGt	p.S838C	TBC1D32_ENST00000398197.2_Intron|TBC1D32_ENST00000398212.2_Missense_Mutation_p.S838C					TBC1 domain family, member 32																		CTTAGCTTCAGAATTCAAAAT	0.254000													6	52					0	0	1	0	0
KIF3C	3797	broad.mit.edu	37	2	26174706	26174706	+	Missense_Mutation	SNP	T	T	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr2:26174706T>C	ENST00000264712.3	-	5	2537	c.1958A>G	c.(1957-1959)gAc>gGc	p.D653G	KIF3C_ENST00000496378.1_5'UTR|KIF3C_ENST00000405914.1_Missense_Mutation_p.D653G	NM_002254.6	NP_002245	O14782	KIF3C_HUMAN	kinesin family member 3C	653	Globular (Potential).				blood coagulation|microtubule-based movement	cytosol|kinesin complex|microtubule	ATP binding|microtubule motor activity			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(8)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTCCTCACAGTCCAGGAAAAG	0.562000													5	50					0	0	1	0	0
TLR10	81793	broad.mit.edu	37	4	38774977	38774977	+	Silent	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr4:38774977C>G	ENST00000308973.4	-	4	2840	c.2235G>C	c.(2233-2235)ctG>ctC	p.L745L	TLR10_ENST00000508334.1_Silent_p.L745L|TLR10_ENST00000506111.1_Silent_p.L745L|TLR10_ENST00000361424.2_Silent_p.L745L	NM_001017388.2|NM_001195107.1|NM_030956.3	NP_001017388.1|NP_001182036.1|NP_112218.2	Q9BXR5	TLR10_HUMAN	toll-like receptor 10	745	TIR.				inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane	transmembrane receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(2)	25						GGAGAGCTTTCAGTTTATGAT	0.403000													17	49					0	0	1	0	0
SSBP4	170463	broad.mit.edu	37	19	18543829	18543829	+	Silent	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr19:18543829C>T	ENST00000270061.7	+	14	1182	c.888C>T	c.(886-888)atC>atT	p.I296I	SSBP4_ENST00000348495.6_Silent_p.I274I	NM_032627.4	NP_116016.1	Q9BWG4	SSBP4_HUMAN	single stranded DNA binding protein 4							nucleus	single-stranded DNA binding			endometrium(2)|kidney(1)|skin(1)	4						TGAACCCCATCGGGCAGGGCG	0.627000													5	29					0	0	1	0	0
SPTLC2	9517	broad.mit.edu	37	14	77978735	77978735	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr14:77978735C>G	ENST00000216484.2	-	12	1774	c.1581G>C	c.(1579-1581)gaG>gaC	p.E527D		NM_004863.3	NP_004854.1	O15270	SPTC2_HUMAN	serine palmitoyltransferase, long chain base subunit 2	527						integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			kidney(1)|large_intestine(5)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(5)	19			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0346)	L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	CTTCATCTATCTCCTTTAAAG	0.458000													7	30					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577099	7577099	+	Missense_Mutation	SNP	C	C	G	rs121912660		TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr17:7577099C>G	ENST00000420246.2	-	8	971	c.839G>C	c.(838-840)aGa>aCa	p.R280T	TP53_ENST00000413465.2_Intron|TP53_ENST00000359597.4_Missense_Mutation_p.R280T|TP53_ENST00000455263.2_Missense_Mutation_p.R280T|TP53_ENST00000269305.4_Missense_Mutation_p.R280T|TP53_ENST00000445888.2_Missense_Mutation_p.R280T	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	280	Interaction with AXIN1 (By similarity).|Interaction with DNA.|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		R -> G (in sporadic cancers; somatic mutation).|R -> I (in sporadic cancers; somatic mutation).|R -> K (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in a sporadic cancer; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).|R -> T (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R280T(65)|p.R280K(49)|p.R280I(16)|p.0?(8)|p.?(2)|p.R280_D281delRD(2)|p.A276_R283delACPGRDRR(1)|p.C275fs*20(1)|p.A276fs*64(1)|p.L265_K305del41(1)|p.G279_R280delGR(1)|p.F270_D281del12(1)|p.G279fs*59(1)|p.D281fs*24(1)|p.R280fs*62(1)|p.S269fs*21(1)|p.V272_K292del21(1)|p.C275_R283delCACPGRDRR(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCGCCGGTCTCTCCCAGGACA	0.542000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			5	30					0	0	1	0	0
FAM21EP	100421577	broad.mit.edu	37	10	51821255	51821255	+	RNA	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr10:51821255C>G	ENST00000456967.1	-	0	1379					NR_038275.1																						TCCTCATCATCAAAGAGCCCC	0.552000													15	168					0	0	1	0	0
EIF4B	1975	broad.mit.edu	37	12	53433926	53433926	+	Splice_Site	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr12:53433926G>C	ENST00000262056.9	+	15	2081		c.e15-1		RP11-983P16.4_ENST00000552905.1_RNA|EIF4B_ENST00000416762.3_Splice_Site|RP11-983P16.4_ENST00000546566.1_RNA|EIF4B_ENST00000420463.3_Splice_Site|RP11-983P16.4_ENST00000550601.1_RNA	NM_001417.4	NP_001408.2	P23588	IF4B_HUMAN	eukaryotic translation initiation factor 4B						insulin receptor signaling pathway|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	nucleotide binding|translation initiation factor activity			breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|stomach(1)|upper_aerodigestive_tract(1)	22						TTGTGTTACAGAAGTTCAGTT	0.443000													8	32					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32800360	32800360	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr2:32800360G>C	ENST00000421745.2	+	66	13416	c.13282G>C	c.(13282-13284)Gaa>Caa	p.E4428Q		NM_016252.3	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	4428					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					AGAACAGTCAGAATGTCAAAC	0.428000													13	94					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152284482	152284482	+	Silent	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:152284482C>T	ENST00000368799.1	-	3	2915	c.2880G>A	c.(2878-2880)gaG>gaA	p.E960E	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	960	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CAGACCACCTCTCAGAGTCTT	0.582000									Ichthyosis				74	363					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15729952	15729952	+	Silent	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr10:15729952G>A	ENST00000378076.3	-	3	782	c.429C>T	c.(427-429)caC>caT	p.H143H		NM_003638.1	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8	143					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						CTTTTCCTTTGTGAGCTTTCA	0.428000													20	66					0	0	1	0	0
C7orf57	136288	broad.mit.edu	37	7	48081094	48081094	+	Silent	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr7:48081094C>T	ENST00000348904.3	+	3	431	c.219C>T	c.(217-219)ctC>ctT	p.L73L	C7orf57_ENST00000420324.1_Silent_p.L118L|C7orf57_ENST00000435376.1_5'UTR|C7orf57_ENST00000539619.1_Silent_p.L73L|C7orf57_ENST00000430738.1_Silent_p.L118L	NM_001100159.2	NP_001093629.1	Q8NEG2	CG057_HUMAN	chromosome 7 open reading frame 57	73										breast(1)|endometrium(2)|large_intestine(1)|lung(4)|ovary(1)	9						ATGTGAAGCTCGCGAAACAAG	0.557000													5	11					0	0	1	0	0
ZNF507	22847	broad.mit.edu	37	19	32873927	32873927	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr19:32873927G>A	ENST00000311921.4	+	6	2992	c.2800G>A	c.(2800-2802)Gag>Aag	p.E934K	ZNF507_ENST00000544431.1_Missense_Mutation_p.E938K|ZNF507_ENST00000355898.5_Missense_Mutation_p.E934K	NM_001136156.1|NM_014910.4	NP_001129628.1|NP_055725.2	Q8TCN5	ZN507_HUMAN	zinc finger protein 507						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	31	Esophageal squamous(110;0.162)					GAAAGAGCACGAGGGTGAAAT	0.413000													10	56					0	0	1	0	0
SLX4	84464	broad.mit.edu	37	16	3640180	3640180	+	Silent	SNP	G	G	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr16:3640180G>C	ENST00000294008.3	-	12	4099	c.3459C>G	c.(3457-3459)ctC>ctG	p.L1153L		NM_032444.2	NP_115820.2	Q8IY92	SLX4_HUMAN	SLX4 structure-specific endonuclease subunit	1153	Interaction with PLK1 and TERF2-TERF2IP.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding			breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	76						AGTCCAGTAAGAGGATGACCT	0.433000								Direct reversal of damage					14	76					0	0	1	0	0
PCDHA10	56139	broad.mit.edu	37	5	140236795	140236795	+	Silent	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr5:140236795C>T	ENST00000307360.5	+	1	1162	c.1162C>T	c.(1162-1164)Ctg>Ttg	p.L388L	PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Silent_p.L388L|PCDHA4_ENST00000512229.2_Intron	NM_018901.2	NP_061724.1														NS(1)|breast(11)|cervix(1)|endometrium(11)|kidney(5)|large_intestine(13)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	79			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACCTGCTCTCTGACGCCTCA	0.547000													12	76					0	0	1	0	0
USP32	84669	broad.mit.edu	37	17	58260575	58260575	+	Silent	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr17:58260575C>G	ENST00000300896.4	-	31	4268	c.4074G>C	c.(4072-4074)ctG>ctC	p.L1358L	USP32_ENST00000592339.1_Silent_p.L1028L	NM_032582.3	NP_115971.2	Q8NFA0	UBP32_HUMAN	ubiquitin specific peptidase 32	1358					protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(5)|endometrium(5)|kidney(4)|large_intestine(12)|liver(1)|lung(24)|pancreas(1)|prostate(3)|skin(3)|urinary_tract(1)	62	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			GGCTTTTGCTCAGGAGCACGT	0.582000													6	88					0	0	1	0	0
RFPL2	10739	broad.mit.edu	37	22	32588966	32588966	+	Missense_Mutation	SNP	A	A	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr22:32588966A>T	ENST00000400236.3	-	4	1414	c.209T>A	c.(208-210)cTg>cAg	p.L70Q	RFPL2_ENST00000248980.4_Missense_Mutation_p.L99Q|RFPL2_ENST00000400237.1_Missense_Mutation_p.L160Q|RFPL2_ENST00000248983.4_Missense_Mutation_p.L70Q|RFPL2_ENST00000489846.1_5'UTR	NM_001098527.2	NP_001091997.2	O75678	RFPL2_HUMAN	ret finger protein-like 2	160							zinc ion binding			endometrium(2)|kidney(4)|large_intestine(3)|lung(9)|ovary(1)|skin(2)	21						GTGGGAAGCCAGCCTCTCTAG	0.527000													23	56					0	0	1	0	0
DCAF7	10238	broad.mit.edu	37	17	61666498	61666498	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr17:61666498C>G	ENST00000310827.4	+	8	1210	c.993C>G	c.(991-993)atC>atG	p.I331M	DCAF7_ENST00000577702.1_3'UTR|DCAF7_ENST00000415273.2_Missense_Mutation_p.I131M|DCAF7_ENST00000431926.1_Intron	NM_005828.3	NP_005819.3	P61962	DCAF7_HUMAN	DDB1 and CUL4 associated factor 7	331					multicellular organismal development	CUL4 RING ubiquitin ligase complex|cytoplasm|nucleus	protein binding			endometrium(6)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)	18						GGATCGCCATCTGCTACAACA	0.562000													17	44					0	0	1	0	0
EGLN1	54583	broad.mit.edu	37	1	231557029	231557029	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:231557029C>T	ENST00000366641.3	-	1	3761	c.606G>A	c.(604-606)atG>atA	p.M202I		NM_022051.2	NP_071334.1	Q9GZT9	EGLN1_HUMAN	egl-9 family hypoxia-inducible factor 1	202					negative regulation of sequence-specific DNA binding transcription factor activity|oxygen homeostasis|response to hypoxia	cytosol	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptidyl-proline dioxygenase activity|protein binding|zinc ion binding	p.M202I(1)		breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|urinary_tract(1)	16		Prostate(94;0.194)|Acute lymphoblastic leukemia(190;0.244)			Vitamin C(DB00126)	CGTGCTTGTTCATGCACGGCA	0.687000													4	30					0	0	1	0	0
LRRTM1	347730	broad.mit.edu	37	2	80529675	80529675	+	Nonsense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr2:80529675G>A	ENST00000295057.3	-	2	1926	c.1270C>T	c.(1270-1272)Cag>Tag	p.Q424*	CTNNA2_ENST00000540488.1_Intron|CTNNA2_ENST00000466387.1_Intron|CTNNA2_ENST00000496558.1_Intron|LRRTM1_ENST00000409148.1_Nonsense_Mutation_p.Q424*|CTNNA2_ENST00000361291.4_Intron|CTNNA2_ENST00000541047.1_Intron|CTNNA2_ENST00000402739.4_Intron	NM_178839.4	NP_849161.2	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	424						axon|endoplasmic reticulum membrane|growth cone|integral to membrane				NS(1)|breast(1)|endometrium(5)|large_intestine(7)|liver(1)|lung(33)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	63						TTGTGGATCTGCACGGCGTTC	0.662000										HNSCC(69;0.2)			7	46					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152326231	152326231	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:152326231C>G	ENST00000388718.5	-	3	4103	c.4031G>C	c.(4030-4032)aGa>aCa	p.R1344T	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1344							calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTGGCTAAATCTCTGTCTTCC	0.483000													18	132					0	0	1	0	0
RAP1GDS1	5910	broad.mit.edu	37	4	99214603	99214603	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr4:99214603G>A	ENST00000408927.3	+	2	162	c.49G>A	c.(49-51)Gac>Aac	p.D17N	RAP1GDS1_ENST00000380158.4_Missense_Mutation_p.D18N|RAP1GDS1_ENST00000453712.2_Missense_Mutation_p.D18N|RAP1GDS1_ENST00000512857.1_3'UTR|RAP1GDS1_ENST00000408900.3_Missense_Mutation_p.D17N|RAP1GDS1_ENST00000264572.7_Missense_Mutation_p.D18N|RAP1GDS1_ENST00000339360.5_Missense_Mutation_p.D18N	NM_001100426.1|NM_001100427.1|NM_021159.4	NP_001093896.1|NP_001093897.1|NP_066982.3	P52306	GDS1_HUMAN	RAP1, GTP-GDP dissociation stimulator 1	17							binding|GTPase activator activity			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)	28				OV - Ovarian serous cystadenocarcinoma(123;2.9e-07)|LUSC - Lung squamous cell carcinoma(1;0.0253)|Lung(1;0.0576)		AACAGCTGTTGACAAGACTGA	0.353000			T	NUP98	T-ALL								4	32					0	0	1	0	0
TK1	7083	broad.mit.edu	37	17	76182885	76182885	+	Silent	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr17:76182885C>T	ENST00000588734.1	-	2	319	c.81G>A	c.(79-81)ccG>ccA	p.P27P	TK1_ENST00000301634.7_Silent_p.P27P|TK1_ENST00000590862.1_Silent_p.P27P|TK1_ENST00000405273.1_Silent_p.P27P|TK1_ENST00000590430.1_Silent_p.P27P			P04183	KITH_HUMAN	thymidine kinase 1, soluble	27					DNA replication|protein homotetramerization|pyrimidine base metabolic process|pyrimidine nucleoside salvage	cytosol	ATP binding|thymidine kinase activity|zinc ion binding			endometrium(1)|large_intestine(1)|urinary_tract(2)	4			BRCA - Breast invasive adenocarcinoma(99;0.00269)|OV - Ovarian serous cystadenocarcinoma(97;0.0804)|Lung(188;0.23)			CTGAGAACATCGGCCCGAGAA	0.632000													2	0					0	0	1	0	0
CELF3	11189	broad.mit.edu	37	1	151681756	151681756	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:151681756C>G	ENST00000290583.4	-	4	1139	c.346G>C	c.(346-348)Gag>Cag	p.E116Q	CELF3_ENST00000290585.4_Missense_Mutation_p.E116Q|CELF3_ENST00000470688.1_5'UTR	NM_001172648.1|NM_007185.4	NP_001166119.1|NP_009116.3	Q5SZQ8	CELF3_HUMAN	CUGBP, Elav-like family member 3	116	RRM 2.				nuclear mRNA splicing, via spliceosome|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	mRNA binding|nucleotide binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)	21						CCGAAGGGCTCAAACATCTTC	0.617000													15	181					0	0	1	0	0
FZD10	11211	broad.mit.edu	37	12	130648351	130648351	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr12:130648351C>T	ENST00000539839.1	+	1	1348	c.766C>T	c.(766-768)Cgc>Tgc	p.R256C	FZD10_ENST00000229030.4_Silent_p.I288I	NM_007197.3	NP_009128.1	Q9ULW2	FZD10_HUMAN	frizzled family receptor 10	0					brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|pancreas(1)|prostate(3)|urinary_tract(1)	35	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)		CCGAGAGCATCGCCTGCGACC	0.642000													8	49					0	0	1	0	0
TRIM33	51592	broad.mit.edu	37	1	115053194	115053195	+	Frame_Shift_Ins	INS	-	-	C			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:115053194_115053195insC	ENST00000358465.2	-	1	586_587	c.503_504insG	c.(502-504)ggcfs	p.G168fs	TRIM33_ENST00000369543.2_Frame_Shift_Ins_p.G168fs	NM_015906.3	NP_056990.3	Q9UPN9	TRI33_HUMAN	tripartite motif containing 33	168					negative regulation of BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	nucleus	co-SMAD binding|DNA binding|ligase activity|R-SMAD binding|zinc ion binding			breast(2)|central_nervous_system(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	48	all_epithelial(7;0.000132)|all_lung(7;0.00106)|Lung SC(450;0.184)	all_cancers(81;3.03e-08)|all_epithelial(167;3.24e-08)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		CGCCGTTGCTGCCCCCCGGGAT	0.698			T	RET	papillary thyroid								2	4	---	---	---	---					
RPTN	126638	broad.mit.edu	37	1	152127881	152127884	+	Frame_Shift_Del	DEL	TGTC	TGTC	-			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr1:152127881_152127884delTGTC	ENST00000316073.3	-	3	1755_1758	c.1691_1694delGACA	c.(1690-1695)agacaafs	p.RQ564fs		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	564	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding			breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						GCTCTGGCCTTGTCTGTCTGTCTG	0.485													7	690	---	---	---	---					
PTH1R	5745	broad.mit.edu	37	3	46944832	46944832	+	Frame_Shift_Del	DEL	G	G	-			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr3:46944832delG	ENST00000313049.5	+	14	1671	c.1468delG	c.(1468-1470)gggfs	p.G490fs	PTH1R_ENST00000430002.2_Frame_Shift_Del_p.G490fs|PTH1R_ENST00000418619.1_Frame_Shift_Del_p.G490fs|PTH1R_ENST00000449590.1_Frame_Shift_Del_p.G490fs			Q03431	PTH1R_HUMAN	parathyroid hormone 1 receptor	490						cytoplasm|integral to plasma membrane|nucleus	parathyroid hormone receptor activity|peptide hormone binding|protein self-association			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(5)|skin(2)|stomach(1)|urinary_tract(2)	19						GGCACGCAGCGGGAGCAGCAG	0.617													7	30	---	---	---	---					
PSPH	5723	broad.mit.edu	37	7	56087292	56087292	+	Splice_Site	DEL	C	C	-			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr7:56087292delC	ENST00000395471.3	-	5	1081		c.e5+1		PSPH_ENST00000275605.3_Splice_Site|PSPH_ENST00000459834.1_Intron			P78330	SERB_HUMAN	phosphoserine phosphatase						L-serine biosynthetic process	cytoplasm	calcium ion binding|magnesium ion binding|phosphoserine phosphatase activity|protein homodimerization activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|ovary(1)|skin(1)	11	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			GTTCCTCTTACCTTATGCCGG	0.577													12	172	---	---	---	---					
CEP78	84131	broad.mit.edu	37	9	80863781	80863781	+	Frame_Shift_Del	DEL	T	T	-			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr9:80863781delT	ENST00000424347.2	+	8	1350	c.1061delT	c.(1060-1062)attfs	p.I354fs	CEP78_ENST00000277082.5_Frame_Shift_Del_p.I354fs|CEP78_ENST00000376598.2_Frame_Shift_Del_p.I354fs|CEP78_ENST00000376597.4_Frame_Shift_Del_p.I354fs|CEP78_ENST00000415759.2_Frame_Shift_Del_p.I354fs			Q5JTW2	CEP78_HUMAN	centrosomal protein 78kDa	354					G2/M transition of mitotic cell cycle	centrosome|cytosol				breast(1)|cervix(1)|endometrium(5)|large_intestine(7)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	21						AAAGCTACTATTAGAATTGGT	0.343													2	4	---	---	---	---					
MICAL2	9645	broad.mit.edu	37	11	12264257	12264259	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr11:12264257_12264259delAAG	ENST00000256194.4	+	20	2884_2886	c.2596_2598delAAG	c.(2596-2598)aagdel	p.K866del	MICAL2_ENST00000342902.5_In_Frame_Del_p.K866del|MICAL2_ENST00000379612.3_Intron|MICAL2_ENST00000537344.1_Intron|MICAL2_ENST00000527546.1_Intron	NM_001282663.1|NM_014632.2	NP_001269592.1|NP_055447.1	O94851	MICA2_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 2	866						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding	p.K866N(1)		breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	47				Epithelial(150;0.00552)		ATTTCACACAAAGAACATTAAGG	0.502													9	77	---	---	---	---					
ZNF528-AS1	102724105	broad.mit.edu	37	19	52896073	52896074	+	RNA	DEL	TA	TA	-			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr19:52896073_52896074delTA	ENST00000601562.1	-	0	784																											GTGGAAGCTGTATATATATATA	0.460													3	5	---	---	---	---					
CNOT3	4849	broad.mit.edu	37	19	54649689	54649689	+	Frame_Shift_Del	DEL	G	G	-			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr19:54649689delG	ENST00000406403.1	+	8	2350	c.747delG	c.(745-747)atgfs	p.M249fs	CNOT3_ENST00000358389.3_Frame_Shift_Del_p.M68fs|CNOT3_ENST00000221232.5_Frame_Shift_Del_p.M249fs			O75175	CNOT3_HUMAN	CCR4-NOT transcription complex, subunit 3	249					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(3)|prostate(7)|urinary_tract(3)	28	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					ACAGCCACATGGAGGATGAGA	0.647													7	58	---	---	---	---					
CD93	22918	broad.mit.edu	37	20	23066469	23066469	+	Frame_Shift_Del	DEL	C	C	-			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr20:23066469delC	ENST00000246006.4	-	1	508	c.361delG	c.(361-363)gagfs	p.E121fs		NM_012072.3	NP_036204.2	Q9NPY3	C1QR1_HUMAN	CD93 molecule	121	C-type lectin.				cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding	p.E121fs*79(2)		NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(14)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					GGCGTGTCCTCCCCCCCGCCC	0.627													2	4	---	---	---	---					
TPTEP1	387590	broad.mit.edu	37	22	17083100	17083100	+	RNA	DEL	A	A	-			TCGA-4Z-AA86-01A-11D-A391-08	TCGA-4Z-AA86-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8659a83-8562-4056-b28a-e588b68c0276	c92554d9-993d-4abf-933e-7435be040b38	g.chr22:17083100delA	ENST00000426585.1	+	0	167																											AGAGAGCCAGAAAGAAGTAAG	0.751													2	4	---	---	---	---