Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
CDK11B	984	broad.mit.edu	37	1	1572053	1572053	+	Silent	SNP	C	C	T	rs17424311		TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:1572053C>T	uc001agv.1	-	21	2019	c.1908G>A	c.(1906-1908)AAG>AAA	p.K636K	CDK11B_uc009vkj.2_Silent_p.K293K|CDK11B_uc001ags.1_Silent_p.K494K|CDK11B_uc001agt.1_Silent_p.K419K|CDK11B_uc001aha.1_Silent_p.K602K|CDK11B_uc001agw.1_Silent_p.K591K|CDK11B_uc001agy.1_Silent_p.K634K|CDK11B_uc001agx.1_Silent_p.K625K|CDK11B_uc001agz.1_Silent_p.K380K	NM_033486	NP_277021	P21127	CD11B_HUMAN	cell division cycle 2-like 1 (PITSLRE proteins)	649	Protein kinase.				apoptosis|cell proliferation|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			skin(1)	1						CCTTGAACACCTTGTTGATCT	0.607		NaN											0	0	0	0.001984	0	7	64									
TNFRSF9	3604	broad.mit.edu	37	1	7993281	7993281	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:7993281G>A	uc001aot.2	-	7	748	c.620C>T	c.(619-621)ACG>ATG	p.T207M		NM_001561	NP_001552	Q07011	TNR9_HUMAN	tumor necrosis factor receptor superfamily,	207	Helical; (Potential).				induction of apoptosis|negative regulation of cell proliferation	integral to plasma membrane	binding|receptor activity			large_intestine(1)|lung(1)|ovary(1)|skin(1)	4	Ovarian(185;0.0634)|all_lung(157;0.151)	all_epithelial(116;9.63e-21)|all_lung(118;1.29e-06)|Lung NSC(185;7.5e-06)|Renal(390;0.000147)|Breast(348;0.000625)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;2.93e-71)|GBM - Glioblastoma multiforme(8;3.72e-37)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;7.71e-06)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000419)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00103)|READ - Rectum adenocarcinoma(331;0.0649)		GAAACGGAGCGTGAGGAAGAA	0.448		NaN											0	0	0	0.000602	0	5	40									
VPS13D	55187	broad.mit.edu	37	1	12378341	12378341	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:12378341C>T	uc001atv.2	+	31	7502	c.7361C>T	c.(7360-7362)TCT>TTT	p.S2454F	VPS13D_uc001atw.2_Missense_Mutation_p.S2454F|VPS13D_uc001atx.2_Missense_Mutation_p.S1642F|VPS13D_uc001aty.1_Missense_Mutation_p.S192F	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	2454					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		ACCAAGCGGTCTTCCCTTCCT	0.443		NaN											0	0	0	0.008291	0	11	93									
DNAJC16	23341	broad.mit.edu	37	1	15890478	15890478	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:15890478G>A	uc001aws.2	+	10	1513	c.1393G>A	c.(1393-1395)GAA>AAA	p.E465K	DNAJC16_uc001awr.1_Missense_Mutation_p.E465K|DNAJC16_uc001awt.2_Missense_Mutation_p.E153K|DNAJC16_uc001awu.2_RNA	NM_015291	NP_056106	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	465	Cytoplasmic (Potential).				cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			urinary_tract(1)|lung(1)|kidney(1)	3		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		TAAAACCCTGGAAGACCCTTG	0.453		NaN											0	0	0	0.00278	0	24	206									
DNAJC16	23341	broad.mit.edu	37	1	15894468	15894468	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:15894468G>C	uc001aws.2	+	15	2265	c.2145G>C	c.(2143-2145)AAG>AAC	p.K715N	DNAJC16_uc001awt.2_Missense_Mutation_p.K403N|DNAJC16_uc001awu.2_RNA	NM_015291	NP_056106	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	715	Extracellular (Potential).				cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			urinary_tract(1)|lung(1)|kidney(1)	3		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		AGCCCCAAAAGACAGTCGAAG	0.488		NaN											0	0	0	0.010729	0	12	100									
DNAJC16	23341	broad.mit.edu	37	1	15894475	15894475	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:15894475G>A	uc001aws.2	+	15	2272	c.2152G>A	c.(2152-2154)GAA>AAA	p.E718K	DNAJC16_uc001awt.2_Missense_Mutation_p.E406K|DNAJC16_uc001awu.2_RNA	NM_015291	NP_056106	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	718	Poly-Glu.|Extracellular (Potential).				cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			urinary_tract(1)|lung(1)|kidney(1)	3		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		AAAGACAGTCGAAGAGGAGGA	0.498		NaN											0	0	0	0.010729	0	11	96									
PUM1	9698	broad.mit.edu	37	1	31439030	31439030	+	Nonsense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:31439030G>A	uc001bsi.1	-	13	1998	c.1885C>T	c.(1885-1887)CAG>TAG	p.Q629*	PUM1_uc001bsf.1_Nonsense_Mutation_p.Q295*|PUM1_uc001bsg.1_Nonsense_Mutation_p.Q442*|PUM1_uc001bsh.1_Nonsense_Mutation_p.Q629*|PUM1_uc001bsj.1_Nonsense_Mutation_p.Q603*|PUM1_uc010oga.1_Nonsense_Mutation_p.Q485*|PUM1_uc001bsk.1_Nonsense_Mutation_p.Q665*|PUM1_uc010ogb.1_Nonsense_Mutation_p.Q570*	NM_014676	NP_055491	Q14671	PUM1_HUMAN	pumilio 1 isoform 2	629					cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		ggctggggctgaggctgCTGT	0.423		NaN											0	0	0	0.00632	0	29	98									
MAP7D1	55700	broad.mit.edu	37	1	36640550	36640550	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:36640550C>T	uc001bzz.2	+	6	1007	c.791C>T	c.(790-792)TCT>TTT	p.S264F	MAP7D1_uc001caa.2_Missense_Mutation_p.S264F|MAP7D1_uc001cab.2_Intron|MAP7D1_uc001cac.2_5'UTR|MAP7D1_uc001cad.2_5'Flank	NM_018067	NP_060537	Q3KQU3	MA7D1_HUMAN	MAP7 domain containing 1	264						cytoplasm|spindle				ovary(3)|breast(2)	5		Myeloproliferative disorder(586;0.0393)				CACGTGGACTCTATAATCAAC	0.607		NaN											0	0	0	0.009096	0	4	36									
THRAP3	9967	broad.mit.edu	37	1	36766675	36766675	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:36766675G>A	uc001cae.3	+	10	2716	c.2492G>A	c.(2491-2493)CGA>CAA	p.R831Q	THRAP3_uc001caf.3_Missense_Mutation_p.R831Q	NM_005119	NP_005110	Q9Y2W1	TR150_HUMAN	thyroid hormone receptor associated protein 3	831					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(5)|lung(3)|breast(1)	9		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GGCAGAGCTCGAGGAACCTTT	0.502		NaN	T	USP6	aneurysmal bone cysts								0	0	0	0.009096	0	4	41									
PPCS	79717	broad.mit.edu	37	1	42922346	42922346	+	Missense_Mutation	SNP	T	T	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:42922346T>G	uc001chl.2	+	1	174	c.110T>G	c.(109-111)GTG>GGG	p.V37G	ZMYND12_uc001chj.2_5'Flank|ZMYND12_uc010ojt.1_5'Flank|PPCS_uc001chk.2_Intron	NM_024664	NP_078940	Q9HAB8	PPCS_HUMAN	phosphopantothenoylcysteine synthetase isoform	37					coenzyme biosynthetic process|pantothenate metabolic process	cytosol	phosphopantothenate--cysteine ligase activity				0	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GGCCGGCGGGTGGTGTTGGTT	0.711		NaN											0	0	0	0.011902	0	10	35									
KIAA0467	23334	broad.mit.edu	37	1	43868912	43868912	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:43868912G>A	uc009vws.1	+	2	176	c.92G>A	c.(91-93)CGC>CAC	p.R31H	C1orf84_uc001cjh.2_Missense_Mutation_p.R31H|C1orf84_uc001cji.1_RNA			Q5T011	SZT2_HUMAN	Homo sapiens mRNA for KIAA0467 protein, partial cds.	31						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CGAAATGTTCGCCTGGCTTGG	0.493		NaN											0	0	0	0.001168	0	6	63									
KIAA0467	23334	broad.mit.edu	37	1	43898837	43898837	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:43898837G>A	uc001cjk.1	+	25	3545	c.3083G>A	c.(3082-3084)CGT>CAT	p.R1028H		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	1927						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CTGCAGGACCGTGTGGAAGTG	0.607		NaN											0	0	0	0.001855	0	13	122									
TSPAN1	10103	broad.mit.edu	37	1	46650908	46650908	+	Silent	SNP	T	T	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:46650908T>C	uc001cpd.2	+	8	1070	c.606T>C	c.(604-606)AAT>AAC	p.N202N	TSPAN1_uc009vyd.1_Silent_p.N202N	NM_005727	NP_005718	O60635	TSN1_HUMAN	tetraspan 1	202	Extracellular (Potential).					integral to membrane|lysosomal membrane				ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)	Medulloblastoma(700;0.00498)|all_neural(321;0.0212)				GTTGCTTCAATCAGCTTTTGT	0.537		NaN											0	0	0	0.008871	0	19	300									
CYP4A11	1579	broad.mit.edu	37	1	47395912	47395912	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:47395912C>G	uc001cqp.3	-	12	1486	c.1435G>C	c.(1435-1437)GAG>CAG	p.E479Q		NM_000778	NP_000769	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A,	479					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			ovary(2)|skin(2)	4					NADH(DB00157)	GGCAGCAGCTCAAAGCGGAGC	0.547		NaN											0	0	0	0.010729	0	11	151									
C8A	731	broad.mit.edu	37	1	57347200	57347200	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:57347200G>C	uc001cyo.2	+	5	679	c.547G>C	c.(547-549)GGG>CGG	p.G183R		NM_000562	NP_000553	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	183	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3						GGTATACAATGGGGAATGGAG	0.463		NaN											0	0	0	0.008291	0	8	133									
TXNIP	10628	broad.mit.edu	37	1	145440476	145440476	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:145440476G>C	uc001enn.3	+	5	1123	c.782G>C	c.(781-783)AGG>ACG	p.R261T	NBPF10_uc001emp.3_Intron|TXNIP_uc001enm.1_Intron|TXNIP_uc010oys.1_Missense_Mutation_p.R206T	NM_006472	NP_006463	Q9H3M7	TXNIP_HUMAN	thioredoxin interacting protein	261					cell cycle|keratinocyte differentiation|transcription, DNA-dependent		ubiquitin protein ligase binding			ovary(2)	2	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CAGAAGATCAGGCCTTCTATC	0.488		NaN											0	0	0	0.005443	0	25	186									
TXNIP	10628	broad.mit.edu	37	1	145440481	145440481	+	Missense_Mutation	SNP	T	T	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:145440481T>C	uc001enn.3	+	5	1128	c.787T>C	c.(787-789)TCT>CCT	p.S263P	NBPF10_uc001emp.3_Intron|TXNIP_uc001enm.1_Intron|TXNIP_uc010oys.1_Missense_Mutation_p.S208P	NM_006472	NP_006463	Q9H3M7	TXNIP_HUMAN	thioredoxin interacting protein	263					cell cycle|keratinocyte differentiation|transcription, DNA-dependent		ubiquitin protein ligase binding			ovary(2)	2	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GATCAGGCCTTCTATCCTGGG	0.493		NaN											0	0	0	0.00632	0	25	185									
TCHH	7062	broad.mit.edu	37	1	152080154	152080154	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:152080154C>T	uc001ezp.2	-	2	5539	c.5539G>A	c.(5539-5541)GCG>ACG	p.A1847T	TCHH_uc009wne.1_Missense_Mutation_p.A1847T	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1847	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGCTCCTCCGCCCGGTACTGC	0.572		NaN											0	0	0	0.006214	0	8	103									
TCHH	7062	broad.mit.edu	37	1	152080660	152080660	+	Missense_Mutation	SNP	T	T	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:152080660T>G	uc001ezp.2	-	2	5033	c.5033A>C	c.(5032-5034)GAA>GCA	p.E1678A	TCHH_uc009wne.1_Missense_Mutation_p.E1678A	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1678	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTCCTCCCCTTCCTGGAGCAG	0.597		NaN											0	0	0	0.006122	0	17	170									
TCHH	7062	broad.mit.edu	37	1	152084447	152084447	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:152084447C>T	uc001ezp.2	-	2	1246	c.1246G>A	c.(1246-1248)GAG>AAG	p.E416K	TCHH_uc009wne.1_Missense_Mutation_p.E416K	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	416	8 X 6 AA tandem repeats of R-R-E-Q-Q-L.|2-7.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			Agctgctgctcgcgcctcagc	0.095		NaN											0	0	0	0.000602	0	5	30									
FLG2	388698	broad.mit.edu	37	1	152325730	152325730	+	Nonsense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:152325730G>C	uc001ezw.3	-	3	4605	c.4532C>G	c.(4531-4533)TCA>TGA	p.S1511*	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1511							calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CGAGCCCCCTGAGTGCACTTC	0.493		NaN											0	0	0	0.01441	0	88	364									
OR10J1	26476	broad.mit.edu	37	1	159409753	159409753	+	Missense_Mutation	SNP	C	C	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:159409753C>A	uc010piv.1	+	1	205	c.205C>A	c.(205-207)CCC>ACC	p.P69T	uc001fts.3_Intron	NM_012351	NP_036483	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J,	69	Helical; Name=2; (Potential).				sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0429)					TCTTCACACACCCATGTACTT	0.458		NaN											1	0	1.12685e-05	0.004482	1.18264e-05	9	160									
FCGR2B	2213	broad.mit.edu	37	1	161641372	161641372	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:161641372C>T	uc001gaz.1	+	3	416	c.324C>T	c.(322-324)AGC>AGT	p.S108S	FCGR2B_uc009wum.1_Silent_p.S108S|FCGR2B_uc001gay.1_Silent_p.S107S|FCGR2B_uc001gba.1_Silent_p.S107S|FCGR2B_uc001gbb.1_Silent_p.S108S|FCGR2B_uc009wun.1_Silent_p.S101S	NM_004001	NP_003992	P31994	FCG2B_HUMAN	Fc fragment of IgG, low affinity IIb, receptor	108	Ig-like C2-type 1.|Extracellular (Potential).				immune response|interspecies interaction between organisms|regulation of immune response	integral to membrane|plasma membrane	IgG binding|receptor activity				0	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	ACAATGACAGCGGGGAGTACA	0.592		NaN	T	NaN	ALL								0	0	0	0.010729	0	10	155									
TOR1AIP1	26092	broad.mit.edu	37	1	179852011	179852011	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:179852011G>A	uc001gnq.2	+	1	592	c.374G>A	c.(373-375)CGA>CAA	p.R125Q	TOR1AIP1_uc001gnp.1_Missense_Mutation_p.R125Q	NM_015602	NP_056417	Q5JTV8	TOIP1_HUMAN	lamina-associated polypeptide 1B	125	Nuclear (Potential).					integral to membrane|nuclear inner membrane				breast(1)|central_nervous_system(1)	2						ATGAAGACGCGAAGGACTACC	0.587		NaN											0	0	0	0.006214	0	9	90									
KIF21B	23046	broad.mit.edu	37	1	200946381	200946381	+	Silent	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:200946381G>A	uc001gvs.1	-	31	4601	c.4284C>T	c.(4282-4284)TAC>TAT	p.Y1428Y	KIF21B_uc001gvr.1_Silent_p.Y1415Y|KIF21B_uc009wzl.1_Silent_p.Y1428Y|KIF21B_uc010ppn.1_Silent_p.Y1415Y	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	1428	WD 3.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						CCGAGGCGGCGTACAGCATGG	0.642		NaN											0	0	0	0.009096	0	4	150									
ATP2B4	493	broad.mit.edu	37	1	203681223	203681223	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:203681223G>C	uc001gzw.2	+	13	3051	c.2167G>C	c.(2167-2169)GAA>CAA	p.E723Q	ATP2B4_uc001gzv.2_Missense_Mutation_p.E723Q|ATP2B4_uc009xaq.2_Missense_Mutation_p.E723Q	NM_001684	NP_001675	P23634	AT2B4_HUMAN	plasma membrane calcium ATPase 4 isoform 4b	723	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|skin(1)	3	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CCTGTGCTTAGAAGGCAAAGA	0.542		NaN											0	0	0	0.006214	0	9	81									
RPS6KC1	26750	broad.mit.edu	37	1	213415603	213415603	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:213415603C>T	uc010ptr.1	+	11	2943	c.2784C>T	c.(2782-2784)CGC>CGT	p.R928R	RPS6KC1_uc001hkd.2_Silent_p.R916R|RPS6KC1_uc010pts.1_Silent_p.R716R|RPS6KC1_uc010ptt.1_Silent_p.R716R|RPS6KC1_uc010ptu.1_Silent_p.R747R|RPS6KC1_uc010ptv.1_Silent_p.R463R|RPS6KC1_uc001hke.2_Silent_p.R747R	NM_012424	NP_036556	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide	928	Protein kinase 2.				cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(3)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		TTGTGTGCCGCGATTTGAACC	0.433		NaN											0	0	0	0.006214	0	9	102									
LYST	1130	broad.mit.edu	37	1	235826288	235826288	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:235826288C>T	uc001hxj.2	-	53	11533	c.11358G>A	c.(11356-11358)TTG>TTA	p.L3786L	LYST_uc001hxi.2_Silent_p.L1010L	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	3786	WD 7.				defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TTGGCTGTTTCAAGCGCTGCT	0.458		NaN							Chediak-Higashi_syndrome				0	0	0	0.004482	0	9	118									
LYST	1130	broad.mit.edu	37	1	235972124	235972124	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:235972124G>A	uc001hxj.2	-	5	2169	c.1994C>T	c.(1993-1995)TCA>TTA	p.S665L	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA|LYST_uc001hxl.1_Missense_Mutation_p.S665L	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	665	WD 1.				defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			GGATAAACTTGAGGAGAGTTC	0.408		NaN							Chediak-Higashi_syndrome				0	0	0	0.000602	0	5	70									
OR2T12	127064	broad.mit.edu	37	1	248458397	248458397	+	Missense_Mutation	SNP	G	G	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:248458397G>T	uc010pzj.1	-	1	484	c.484C>A	c.(484-486)CTG>ATG	p.L162M		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	162	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			GGGAAGCTCAGGGTAGCAACA	0.577		NaN											1	0	0.00307968	0.00308	0.00312888	8	193									
ITIH2	3698	broad.mit.edu	37	10	7768927	7768927	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr10:7768927G>A	uc001ijs.2	+	10	1161	c.999G>A	c.(997-999)ATG>ATA	p.M333I		NM_002216	NP_002207	P19823	ITIH2_HUMAN	inter-alpha globulin inhibitor H2 polypeptide	333	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)|pancreas(1)|skin(1)	3						TGGAAGCAATGAAGACCATAT	0.393		NaN											0	0	0	0.000602	0	5	70									
FRMD4A	55691	broad.mit.edu	37	10	13712435	13712435	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr10:13712435C>T	uc001ims.2	-	17	1697	c.1345G>A	c.(1345-1347)GAT>AAT	p.D449N	FRMD4A_uc009xjf.1_Missense_Mutation_p.D449N|FRMD4A_uc001imt.1_Missense_Mutation_p.D482N	NM_018027	NP_060497	Q9P2Q2	FRM4A_HUMAN	FERM domain containing 4A	449						cytoplasm|cytoskeleton	binding			ovary(1)|skin(1)|pancreas(1)	3						TTCTGTTCATCCAGTTTGAAG	0.498		NaN											0	0	0	0.00245	0	15	95									
FRMD4A	55691	broad.mit.edu	37	10	13712504	13712504	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr10:13712504C>T	uc001ims.2	-	17	1628	c.1276G>A	c.(1276-1278)GAA>AAA	p.E426K	FRMD4A_uc009xjf.1_Missense_Mutation_p.E426K|FRMD4A_uc001imt.1_Missense_Mutation_p.E459K	NM_018027	NP_060497	Q9P2Q2	FRM4A_HUMAN	FERM domain containing 4A	426						cytoplasm|cytoskeleton	binding			ovary(1)|skin(1)|pancreas(1)	3						AGGGGATATTCTACTGGCAGC	0.483		NaN											0	0	0	0.004007	0	15	110									
ZNF438	220929	broad.mit.edu	37	10	31133898	31133898	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr10:31133898C>T	uc010qdz.1	-	8	2914	c.2479G>A	c.(2479-2481)GAG>AAG	p.E827K	ZNF438_uc001ivn.2_Missense_Mutation_p.E778K|ZNF438_uc010qdy.1_Missense_Mutation_p.E817K|ZNF438_uc001ivo.3_Missense_Mutation_p.E391K|ZNF438_uc009xlg.2_Missense_Mutation_p.E827K|ZNF438_uc001ivp.3_Missense_Mutation_p.E817K|ZNF438_uc010qea.1_Missense_Mutation_p.E827K|ZNF438_uc010qeb.1_Missense_Mutation_p.E827K	NM_182755	NP_877432	Q7Z4V0	ZN438_HUMAN	zinc finger protein 438 isoform a	827					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)	2		Prostate(175;0.0587)				TCTCATTTCTCAGCTTCACTG	0.512		NaN											0	0	0	0.008361	0	29	298									
PARD3	56288	broad.mit.edu	37	10	34420399	34420399	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr10:34420399G>C	uc010qej.1	-	23	3541	c.3541C>G	c.(3541-3543)CAA>GAA	p.Q1181E	PARD3_uc010qek.1_Missense_Mutation_p.Q1178E|PARD3_uc010qel.1_Missense_Mutation_p.Q1144E|PARD3_uc010qem.1_Missense_Mutation_p.Q1165E|PARD3_uc010qen.1_Missense_Mutation_p.Q1135E|PARD3_uc010qeo.1_Missense_Mutation_p.Q1098E|PARD3_uc010qep.1_Missense_Mutation_p.Q1091E|PARD3_uc010qeq.1_Missense_Mutation_p.Q1069E	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	1181					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)				ACCCAGGGTTGCTCAAAACTA	0.463		NaN											0	0	0	0.003163	0	15	57									
ZNF37A	7587	broad.mit.edu	37	10	38406754	38406754	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr10:38406754C>G	uc001izk.2	+	8	1494	c.675C>G	c.(673-675)AGC>AGG	p.S225R	ZNF37A_uc001izl.2_Missense_Mutation_p.S225R|ZNF37A_uc001izm.2_Missense_Mutation_p.S225R	NM_001007094	NP_001007095	P17032	ZN37A_HUMAN	zinc finger protein 37a	225						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)	1						ACCCATTCAGCCAGAAGTTAA	0.348		NaN											0	0	0	0.001168	0	6	55									
EIF5AL1	143244	broad.mit.edu	37	10	81272751	81272751	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr10:81272751G>A	uc009xrx.2	+	1	395	c.346G>A	c.(346-348)GAG>AAG	p.E116K	uc010qls.1_5'Flank	NM_001099692	NP_001093162	Q6IS14	IF5AL_HUMAN	eukaryotic translation initiation factor 5A-like	116					mRNA transport|peptidyl-lysine modification to hypusine|positive regulation of translational elongation|positive regulation of translational termination|protein transport|translational frameshifting|transmembrane transport	endoplasmic reticulum membrane|nuclear pore	ribosome binding|translation elongation factor activity				0	all_cancers(46;0.197)|Breast(12;0.000326)|Prostate(51;0.00985)|all_epithelial(25;0.0149)		Epithelial(14;0.00957)|all cancers(16;0.0179)|Colorectal(32;0.229)			TCGTCTCCCTGAGGGAGACCT	0.537		NaN											0	0	0	0.00308	0	6	154									
TSPAN14	81619	broad.mit.edu	37	10	82269071	82269071	+	Silent	SNP	C	C	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr10:82269071C>A	uc001kcj.3	+	5	401	c.294C>A	c.(292-294)ATC>ATA	p.I98I	TSPAN14_uc009xss.2_Intron|TSPAN14_uc001kci.3_Silent_p.I81I	NM_030927	NP_112189	Q8NG11	TSN14_HUMAN	tetraspanin 14 isoform 1	98	Helical; (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)	2			Colorectal(32;0.229)			GTGGCACCATCGTGCTCATCT	0.617		NaN											1	0	0.00198382	0.001984	0.00202847	7	42									
CHST15	51363	broad.mit.edu	37	10	125798151	125798151	+	Missense_Mutation	SNP	G	G	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr10:125798151G>T	uc001lhl.2	-	4	1583	c.1070C>A	c.(1069-1071)GCC>GAC	p.A357D	CHST15_uc001lhm.2_Missense_Mutation_p.A357D|CHST15_uc001lhn.2_Missense_Mutation_p.A357D|CHST15_uc010que.1_Missense_Mutation_p.A357D|CHST15_uc001lho.2_Missense_Mutation_p.A357D	NM_015892	NP_056976	Q7LFX5	CHSTF_HUMAN	B cell RAG associated protein	357	Lumenal (Potential).				hexose biosynthetic process	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity			ovary(1)	1						GAACGTCCAGGCATTATTATC	0.547		NaN											1	0	3.86212e-05	0.008291	4.01358e-05	10	52									
MUC5B	727897	broad.mit.edu	37	11	1264405	1264405	+	Missense_Mutation	SNP	A	A	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr11:1264405A>C	uc009ycr.1	+	47	8500	c.8374A>C	c.(8374-8376)ACC>CCC	p.T2792P	MUC5B_uc001ltb.2_Missense_Mutation_p.T2102P	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	2099	7 X Cys-rich subdomain repeats.|11 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CCCGGGGACCACCCACACCGC	0.602		NaN											0	0	0	0.007413	0	7	20									
ST5	6764	broad.mit.edu	37	11	8724142	8724142	+	Silent	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr11:8724142G>C	uc001mgt.2	-	14	2883	c.2697C>G	c.(2695-2697)GTC>GTG	p.V899V	ST5_uc009yfr.2_Silent_p.V479V|ST5_uc001mgu.2_Silent_p.V479V|ST5_uc001mgv.2_Silent_p.V899V|ST5_uc010rbp.1_Silent_p.V412V|ST5_uc009yfs.2_RNA	NM_213618	NP_998783	P78524	ST5_HUMAN	suppression of tumorigenicity 5 isoform 1	899	DENN.				positive regulation of ERK1 and ERK2 cascade		protein binding			upper_aerodigestive_tract(1)	1				Epithelial(150;2.63e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0352)		CCACAAAAATGACCCGGCGCT	0.572		NaN											0	0	0	0.001168	0	6	89									
CHRM4	1132	broad.mit.edu	37	11	46407836	46407836	+	Missense_Mutation	SNP	A	A	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr11:46407836A>G	uc001nct.1	-	1	272	c.272T>C	c.(271-273)GTG>GCG	p.V91A		NM_000741	NP_000732	P08173	ACM4_HUMAN	cholinergic receptor, muscarinic 4	91	Extracellular (By similarity).				cell proliferation	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity				0				GBM - Glioblastoma multiforme(35;0.0254)|Lung(87;0.14)	Atropine(DB00572)|Benzquinamide(DB00767)|Cryptenamine(DB00785)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Thiethylperazine(DB00372)|Tropicamide(DB00809)	GATGATGTACACGGTGTAGAG	0.577		NaN											0	0	0	0.006214	0	10	62									
CABP4	57010	broad.mit.edu	37	11	67223087	67223087	+	Missense_Mutation	SNP	G	G	A	rs149056460		TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr11:67223087G>A	uc001olo.2	+	1	270	c.193G>A	c.(193-195)GAG>AAG	p.E65K	GPR152_uc001olm.2_5'Flank|CABP4_uc001oln.2_Intron	NM_145200	NP_660201	P57796	CABP4_HUMAN	calcium binding protein 4	65					visual perception	cytoplasm|extracellular region|terminal button	calcium ion binding				0			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			GACAGGCCCCGAGGCCCCGGG	0.701		NaN											0	0	0	0.004672	0	3	24									
KRTAP5-10	387273	broad.mit.edu	37	11	71276978	71276978	+	Silent	SNP	C	C	T	rs77786965		TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr11:71276978C>T	uc001oqt.1	+	1	370	c.345C>T	c.(343-345)GGC>GGT	p.G115G		NM_001012710	NP_001012728	Q6L8G5	KR510_HUMAN	keratin associated protein 5-10	115	7 X 4 AA repeats of C-C-X-P.					keratin filament				skin(1)	1						GGGGCTGTGGCTCCTGTGGGG	0.652		NaN											0	0	0	0.006214	0	6	240									
MTNR1B	4544	broad.mit.edu	37	11	92703069	92703069	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr11:92703069C>T	uc001pdk.1	+	1	281	c.178C>T	c.(178-180)CTG>TTG	p.L60L		NM_005959	NP_005950	P49286	MTR1B_HUMAN	melatonin receptor 1B	60	Helical; Name=1; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	GGGCAACCTCCTGGTGATCCT	0.667		NaN											0	0	0	0.001168	0	5	13									
MAML2	84441	broad.mit.edu	37	11	95724768	95724768	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr11:95724768C>G	uc001pfw.1	-	3	3544	c.2259G>C	c.(2257-2259)TTG>TTC	p.L753F		NM_032427	NP_115803	Q8IZL2	MAML2_HUMAN	mastermind-like 2	753					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC1/MAML2(516)|CRTC3/MAML2(26)	salivary_gland(500)|lung(36)|thyroid(4)|breast(3)|skin(2)|ovary(1)	546		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				TCTTTCCCATCAATTGCTGAT	0.488		NaN	T	MECT1|CRTC3	salivary gland mucoepidermoid								0	0	0	0.006122	0	19	109									
ATM	472	broad.mit.edu	37	11	108218071	108218071	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr11:108218071G>C	uc001pkb.1	+	59	9035	c.8650G>C	c.(8650-8652)GAA>CAA	p.E2884Q	ATM_uc009yxr.1_Missense_Mutation_p.E2884Q|C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_Intron|ATM_uc001pke.1_Missense_Mutation_p.E1536Q	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	2884	PI3K/PI4K.				cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GCAGTCAGCAGAACTTGTACA	0.313		NaN	D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			0	0	0	0.008291	0	11	26									
BUD13	84811	broad.mit.edu	37	11	116633771	116633772	+	Missense_Mutation	DNP	CC	CC	AT			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr11:116633771_116633772CC>AT	uc001ppn.2	-	4	567_568	c.533_534GG>AT	c.(532-534)AGG>AAT	p.R178N	BUD13_uc001ppo.2_Missense_Mutation_p.R178N|BUD13_uc009yzc.2_Missense_Mutation_p.R178N	NM_032725	NP_116114	Q9BRD0	BUD13_HUMAN	BUD13 homolog isoform 1	178	Arg-rich.									large_intestine(1)|pancreas(1)	2	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)		GACGGATCCTCCTGGGAGGAGA	0.584		NaN											0	0	0	0.004672	0	33	215									
CXCR5	643	broad.mit.edu	37	11	118754653	118754653	+	Missense_Mutation	SNP	G	G	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr11:118754653G>T	uc001pue.3	+	1	113	c.3G>T	c.(1-3)ATG>ATT	p.M1I		NM_001716	NP_001707	P32302	CXCR5_HUMAN	Burkitt lymphoma receptor 1 isoform 1	1	Extracellular (Potential).				B cell activation|cellular component movement	integral to plasma membrane	C-X-C chemokine receptor activity			breast(1)	1	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.62e-05)		GCACAGCCATGAACTACCCGC	0.577		NaN											1	0	0.00909568	0.009096	0.00918231	4	16									
CDON	50937	broad.mit.edu	37	11	125850958	125850958	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr11:125850958G>A	uc009zbw.2	-	17	3390	c.3262C>T	c.(3262-3264)CAT>TAT	p.H1088Y	CDON_uc001qdb.3_Missense_Mutation_p.H465Y|CDON_uc001qdc.3_Missense_Mutation_p.H1088Y	NM_016952	NP_058648	Q4KMG0	CDON_HUMAN	surface glycoprotein, Ig superfamily member	1088	Cytoplasmic (Potential).				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|skin(2)|breast(1)	6	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		ACTAGATGATGAGGATGTTCA	0.463		NaN											0	0	0	0.009535	0	33	85									
CDON	50937	broad.mit.edu	37	11	125889616	125889616	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr11:125889616C>G	uc009zbw.2	-	4	522	c.394G>C	c.(394-396)GAA>CAA	p.E132Q	CDON_uc001qdc.3_Missense_Mutation_p.E132Q|CDON_uc001qdd.3_RNA|CDON_uc009zbx.2_Missense_Mutation_p.E132Q	NM_016952	NP_058648	Q4KMG0	CDON_HUMAN	surface glycoprotein, Ig superfamily member	132	Extracellular (Potential).|Ig-like C2-type 2.				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|skin(2)|breast(1)	6	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		CTTTTTTCTTCTGCTGTAATA	0.393		NaN											0	0	0	0.00278	0	25	132									
APLP2	334	broad.mit.edu	37	11	130011399	130011399	+	Missense_Mutation	SNP	G	G	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr11:130011399G>T	uc010sby.1	+	16	2123	c.1966G>T	c.(1966-1968)GAC>TAC	p.D656Y	APLP2_uc001qfp.2_Missense_Mutation_p.D644Y|APLP2_uc001qfq.2_Missense_Mutation_p.D588Y|APLP2_uc010sbz.1_Missense_Mutation_p.D444Y|APLP2_uc001qfr.2_Missense_Mutation_p.D410Y|APLP2_uc001qfs.2_Missense_Mutation_p.D415Y|APLP2_uc001qfv.2_Missense_Mutation_p.D547Y|APLP2_uc009zcv.2_Missense_Mutation_p.D4Y	NM_001642	NP_001633	Q06481	APLP2_HUMAN	amyloid beta (A4) precursor-like protein 2	656	Extracellular (Potential).				G-protein coupled receptor protein signaling pathway	integral to membrane|nucleus|plasma membrane	DNA binding|identical protein binding|serine-type endopeptidase inhibitor activity			ovary(3)	3	all_hematologic(175;0.0429)	Breast(109;0.00586)|Lung NSC(97;0.00785)|all_lung(97;0.0154)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0197)|Lung(977;0.24)		TCAGGTCATTGACGAGACTCT	0.498		NaN											1	0	1.02788e-11	0.00499	1.12325e-11	17	43									
PRMT8	56341	broad.mit.edu	37	12	3649787	3649787	+	Missense_Mutation	SNP	T	T	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:3649787T>C	uc001qmf.2	+	2	458	c.91T>C	c.(91-93)TCC>CCC	p.S31P	PRMT8_uc009zed.2_Missense_Mutation_p.S22P|PRMT8_uc009zee.1_RNA	NM_019854	NP_062828	Q9NR22	ANM8_HUMAN	HMT1 hnRNP methyltransferase-like 4	31	SH3-binding 1.				regulation of protein binding	cytoplasm|plasma membrane	histone-arginine N-methyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity			ovary(3)|central_nervous_system(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(31;0.0109)|COAD - Colon adenocarcinoma(12;0.0264)			CAGCCCCCCCTCCCAGCCCCC	0.652		NaN											0	0	0	0.00623	0	22	90									
CLSTN3	9746	broad.mit.edu	37	12	7295617	7295617	+	Missense_Mutation	SNP	A	A	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:7295617A>T	uc001qsr.2	+	11	1971	c.1693A>T	c.(1693-1695)ATG>TTG	p.M565L	CLSTN3_uc001qss.2_Missense_Mutation_p.M577L	NM_014718	NP_055533	Q9BQT9	CSTN3_HUMAN	calsyntenin 3 precursor	565	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			large_intestine(1)	1						GGGCAAAGGCATGAAGGTATT	0.622		NaN											0	0	0	0.00308	0	8	47									
SLC2A3	6515	broad.mit.edu	37	12	8086418	8086418	+	Missense_Mutation	SNP	A	A	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:8086418A>T	uc001qtr.2	-	2	358	c.96T>A	c.(94-96)AAT>AAA	p.N32K	SLC2A3_uc001qts.2_Missense_Mutation_p.N32K	NM_006931	NP_008862	P11169	GTR3_HUMAN	solute carrier family 2 (facilitated glucose	32	Extracellular (Potential).				carbohydrate metabolic process|water-soluble vitamin metabolic process	integral to membrane|plasma membrane	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			ovary(3)|pancreas(1)	4				Kidney(36;0.0866)		TCTCAGGAGCATTGATGACCC	0.428		NaN									OREG0021656	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001168	0	6	73									
CLEC9A	283420	broad.mit.edu	37	12	10205299	10205299	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:10205299G>C	uc001qxa.2	+	4	626	c.13G>C	c.(13-15)GAA>CAA	p.E5Q		NM_207345	NP_997228	Q6UXN8	CLC9A_HUMAN	C-type lectin domain family 9, member A	5	Cytoplasmic (Potential).|ITAM-like.				positive regulation of cytokine secretion|receptor-mediated endocytosis	cell surface|integral to membrane	receptor activity|sugar binding			ovary(1)	1						GCACGAGGAAGAAATATACAC	0.448		NaN											0	0	0	0.010729	0	11	61									
TAS2R31	259290	broad.mit.edu	37	12	11183288	11183288	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:11183288G>C	uc001qzo.1	-	1	719	c.647C>G	c.(646-648)TCT>TGT	p.S216C	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176885	NP_795366	P59538	T2R31_HUMAN	taste receptor, type 2, member 31	216	Cytoplasmic (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity				0						GGGATCTTGAGATCCTTTACC	0.408		NaN											0	0	0	0.008871	0	21	283									
FAM60A	58516	broad.mit.edu	37	12	31446788	31446788	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:31446788C>G	uc010sjz.1	-	4	545	c.306G>C	c.(304-306)AGG>AGC	p.R102S	FAM60A_uc001rkd.2_Missense_Mutation_p.R102S|FAM60A_uc010ska.1_Missense_Mutation_p.R102S|FAM60A_uc001rke.2_Missense_Mutation_p.R102S|FAM60A_uc010skb.1_Intron|FAM60A_uc001rkc.2_Missense_Mutation_p.R127S	NM_021238	NP_067061	Q9NP50	FA60A_HUMAN	family with sequence similarity 60, member A	102											0	all_cancers(9;5.22e-13)|all_epithelial(9;4e-13)|all_lung(12;1.2e-11)|Lung NSC(12;2.17e-09)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0207)|Lung SC(12;0.0592)|Esophageal squamous(101;0.162)					TGCTTTTTATCCTGTTCCCAG	0.333		NaN											0	0	0	0.001984	0	7	35									
TMEM106C	79022	broad.mit.edu	37	12	48360997	48360997	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:48360997C>T	uc001rqp.2	+	7	724	c.609C>T	c.(607-609)TTC>TTT	p.F203F	TMEM106C_uc001rqo.2_Silent_p.F184F|TMEM106C_uc001rqr.2_Silent_p.F203F|TMEM106C_uc001rqq.2_Silent_p.F184F	NM_024056	NP_076961	Q9BVX2	T106C_HUMAN	transmembrane protein 106C isoform a	203	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane					0		Acute lymphoblastic leukemia(13;0.11)		GBM - Glioblastoma multiforme(48;0.241)		GTAGCTTCTTCTGCACGGTAC	0.488		NaN											0	0	0	0.013114	0	45	215									
KRT6A	3853	broad.mit.edu	37	12	52886867	52886867	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:52886867C>T	uc001sam.2	-	1	315	c.106G>A	c.(106-108)GTC>ATC	p.V36I		NM_005554	NP_005545	P02538	K2C6A_HUMAN	keratin 6A	36	Head.				cell differentiation|ectoderm development|positive regulation of cell proliferation	keratin filament	protein binding|structural constituent of cytoskeleton			ovary(4)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.189)		GACACGGAGACGCTGCTGAAG	0.667		NaN											0	0	0	0.001168	0	6	164									
OBFC2B	79035	broad.mit.edu	37	12	56622879	56622879	+	Missense_Mutation	SNP	A	A	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:56622879A>C	uc001ski.2	+	7	642	c.518A>C	c.(517-519)CAC>CCC	p.H173P	OBFC2B_uc001skk.2_Missense_Mutation_p.H198P|OBFC2B_uc001skj.2_Missense_Mutation_p.H189P	NM_024068	NP_076973	Q9BQ15	SOSB1_HUMAN	oligonucleotide/oligosaccharide-binding fold	173	Pro-rich.				double-strand break repair via homologous recombination|G2/M transition checkpoint|response to ionizing radiation	SOSS complex	protein binding|single-stranded DNA binding			ovary(1)	1						ACTCCCTCCCACCCACCCAGC	0.612		NaN						Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					0	0	0	0.010729	0	5	22									
STAT2	6773	broad.mit.edu	37	12	56745131	56745131	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:56745131C>T	uc001slc.2	-	9	964	c.886G>A	c.(886-888)GGG>AGG	p.G296R	STAT2_uc001slb.2_5'Flank|STAT2_uc001sld.2_Missense_Mutation_p.G292R|STAT2_uc010sqn.1_Missense_Mutation_p.G292R	NM_005419	NP_005410	P52630	STAT2_HUMAN	signal transducer and activator of transcription	296					interspecies interaction between organisms|JAK-STAT cascade|regulation of transcription from RNA polymerase II promoter|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	cytosol|nucleoplasm|plasma membrane	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(1)|lung(1)|kidney(1)	3						AGGTCCACCCCTTTGGTCAGA	0.572		NaN											0	0	0	0.003954	0	27	306									
LRP1	4035	broad.mit.edu	37	12	57588794	57588794	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:57588794G>C	uc001snd.2	+	51	8684	c.8218G>C	c.(8218-8220)GAG>CAG	p.E2740Q		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	2740	Extracellular (Potential).|LDL-receptor class A 16.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GGCCCAGTTTGAGTGCCAGAA	0.597		NaN											0	0	0	0.013537	0	13	154									
SRGAP1	57522	broad.mit.edu	37	12	64485155	64485155	+	Silent	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:64485155C>G	uc010ssp.1	+	12	1592	c.1536C>G	c.(1534-1536)GTC>GTG	p.V512V	SRGAP1_uc001srv.2_Intron	NM_020762	NP_065813	Q7Z6B7	SRGP1_HUMAN	SLIT-ROBO Rho GTPase activating protein 1	512	Rho-GAP.				axon guidance	cytosol				ovary(2)|central_nervous_system(2)	4			GBM - Glioblastoma multiforme(3;0.000139)|BRCA - Breast invasive adenocarcinoma(9;0.225)	GBM - Glioblastoma multiforme(28;0.0608)		AAACATTCGTCAAGGTACTGG	0.483		NaN											0	0	0	0.001984	0	6	46									
PTPRB	5787	broad.mit.edu	37	12	71016176	71016176	+	Silent	SNP	A	A	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:71016176A>G	uc001swc.3	-	3	746	c.702T>C	c.(700-702)ACT>ACC	p.T234T	PTPRB_uc001swa.3_Silent_p.T234T|PTPRB_uc001swd.3_Silent_p.T233T|PTPRB_uc009zrr.1_Silent_p.T113T|PTPRB_uc001swe.2_Silent_p.T234T	NM_001109754	NP_001103224	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	Error:Variant_position_missing_in_P23467_after_alignment					angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TTACCTCTTCAGTGGTGCTGG	0.507		NaN											0	0	0	0.006214	0	8	218									
LRRIQ1	84125	broad.mit.edu	37	12	85531742	85531742	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:85531742G>C	uc001tac.2	+	19	4435	c.4324G>C	c.(4324-4326)GAT>CAT	p.D1442H		NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1442										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		TTTTATATTTGATGAAGTAAG	0.284		NaN											0	0	0	0.006214	0	10	46									
NTS	4922	broad.mit.edu	37	12	86272159	86272159	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:86272159C>G	uc001tag.2	+	3	279	c.172C>G	c.(172-174)CTG>GTG	p.L58V		NM_006183	NP_006174	P30990	NEUT_HUMAN	neurotensin/neuromedin N preproprotein	58					regulation of blood vessel size|signal transduction	extracellular region|soluble fraction|transport vesicle	neuropeptide hormone activity				0						GAAGATGACTCTGCTAAATGT	0.328		NaN											0	0	0	0.010729	0	11	133									
MYL2	4633	broad.mit.edu	37	12	111348888	111348888	+	Missense_Mutation	SNP	T	T	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:111348888T>C	uc001try.3	-	7	565	c.494A>G	c.(493-495)AAG>AGG	p.K165R	MYL2_uc001trx.3_Missense_Mutation_p.K146R	NM_000432	NP_000423	P10916	MLRV_HUMAN	slow cardiac myosin regulatory light chain 2	165	EF-hand 3.				cardiac myofibril assembly|heart contraction|muscle filament sliding|negative regulation of cell growth|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	cytosol|myosin complex|sarcomere	actin monomer binding|calcium ion binding|myosin heavy chain binding|structural constituent of muscle			ovary(1)	1						CTCCTAGTCCTTCTCTTCTCC	0.602		NaN											0	0	0	0.004007	0	16	119									
MYL2	4633	broad.mit.edu	37	12	111348892	111348892	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:111348892C>G	uc001try.3	-	7	561	c.490G>C	c.(490-492)GAG>CAG	p.E164Q	MYL2_uc001trx.3_Missense_Mutation_p.E145Q	NM_000432	NP_000423	P10916	MLRV_HUMAN	slow cardiac myosin regulatory light chain 2	164	EF-hand 3.				cardiac myofibril assembly|heart contraction|muscle filament sliding|negative regulation of cell growth|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	cytosol|myosin complex|sarcomere	actin monomer binding|calcium ion binding|myosin heavy chain binding|structural constituent of muscle			ovary(1)	1						TAGTCCTTCTCTTCTCCGTGG	0.607		NaN											0	0	0	0.004007	0	15	122									
PIWIL1	9271	broad.mit.edu	37	12	130846097	130846097	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:130846097C>T	uc001uik.2	+	16	2011	c.1921C>T	c.(1921-1923)CGG>TGG	p.R641W	PIWIL1_uc001uij.1_Missense_Mutation_p.R641W	NM_004764	NP_004755	Q96J94	PIWL1_HUMAN	piwi-like 1	641	RNA-binding (By similarity).|Piwi.				gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		GACAGCTGGGCGGAGGTCAAT	0.478		NaN											0	0	0	0.006122	0	17	130									
MYCBP2	23077	broad.mit.edu	37	13	77672741	77672741	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr13:77672741G>C	uc001vkf.2	-	57	8525	c.8434C>G	c.(8434-8436)CTA>GTA	p.L2812V	MYCBP2_uc010aev.2_Missense_Mutation_p.L2216V|MYCBP2_uc001vkg.1_Missense_Mutation_p.L335V|MYCBP2_uc010aew.2_Missense_Mutation_p.L198V	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	2812					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TTTTGAGGTAGATTTTTATCA	0.473		NaN											0	0	0	0.00308	0	8	116									
MBNL2	10150	broad.mit.edu	37	13	97986694	97986694	+	Silent	SNP	G	G	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr13:97986694G>T	uc010aft.2	+	3	1155	c.339G>T	c.(337-339)GTG>GTT	p.V113V	MBNL2_uc001vmz.2_Silent_p.V113V|MBNL2_uc001vna.2_Silent_p.V113V|MBNL2_uc001vnb.2_RNA|MBNL2_uc010tij.1_Silent_p.V113V	NM_144778	NP_659002	Q5VZF2	MBNL2_HUMAN	muscleblind-like 2 isoform 1	113					mRNA processing|regulation of RNA splicing|RNA splicing	cytoplasm|nucleus	RNA binding|zinc ion binding				0	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.218)			TTCATCCAGTGGTGAGTACAT	0.433		NaN											1	0	0.004672	0.004672	0.00473152	3	56									
MYO16	23026	broad.mit.edu	37	13	109318494	109318494	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr13:109318494G>C	uc001vqt.1	+	2	349	c.223G>C	c.(223-225)GAA>CAA	p.E75Q	MYO16_uc010agk.1_Missense_Mutation_p.E97Q	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	75	ANK 1.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CAATGACAAAGAAGGTACATG	0.418		NaN											0	0	0	0.004672	0	3	21									
OR4L1	122742	broad.mit.edu	37	14	20528361	20528361	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr14:20528361C>T	uc001vwn.1	+	1	158	c.158C>T	c.(157-159)TCA>TTA	p.S53L		NM_001004717	NP_001004717	Q8NH43	OR4L1_HUMAN	olfactory receptor, family 4, subfamily L,	53	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		ACATGTAGGTCAACCCTTCAT	0.423		NaN											0	0	0	0.006214	0	4	125									
ARHGAP5	394	broad.mit.edu	37	14	32560146	32560146	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr14:32560146C>T	uc001wrl.2	+	2	510	c.271C>T	c.(271-273)CAT>TAT	p.H91Y	ARHGAP5_uc001wrm.2_Missense_Mutation_p.H91Y|ARHGAP5_uc001wrn.2_Missense_Mutation_p.H91Y|ARHGAP5_uc001wro.2_Intron|ARHGAP5_uc001wrp.2_Intron	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	91					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		ATGCAAAATTCATGTCATTGA	0.373		NaN											0	0	0	0.001984	0	7	89									
PAX9	5083	broad.mit.edu	37	14	37145475	37145475	+	Nonsense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr14:37145475C>T	uc001wty.3	+	5	1561	c.844C>T	c.(844-846)CAA>TAA	p.Q282*	PAX9_uc010amq.2_RNA	NM_006194	NP_006185	P55771	PAX9_HUMAN	paired box 9	282					multicellular organismal development|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)|Breast(36;0.218)		Lung(8;1.12e-09)|LUAD - Lung adenocarcinoma(9;2.16e-07)|Epithelial(34;0.00357)|all cancers(34;0.00998)|LUSC - Lung squamous cell carcinoma(13;0.0189)	GBM - Glioblastoma multiforme(112;0.0181)		TACCCCAGCCCAAGTGTCGCC	0.532		NaN											0	0	0	0.013537	0	13	111									
DDHD1	80821	broad.mit.edu	37	14	53513571	53513571	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr14:53513571G>A	uc001xai.2	-	13	2848	c.2618C>T	c.(2617-2619)TCC>TTC	p.S873F	DDHD1_uc001xaj.2_Missense_Mutation_p.S852F|DDHD1_uc001xah.2_Missense_Mutation_p.S845F|DDHD1_uc001xag.2_Missense_Mutation_p.S427F	NM_001160148	NP_001153620	Q8NEL9	DDHD1_HUMAN	DDHD domain containing 1 isoform c	873	DDHD.				lipid catabolic process	cytoplasm	hydrolase activity|metal ion binding			ovary(2)	2	Breast(41;0.037)					AACATCCAAGGATGACCAATA	0.433		NaN											0	0	0	0.010729	0	11	65									
DACT1	51339	broad.mit.edu	37	14	59113460	59113460	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr14:59113460G>A	uc001xdw.2	+	4	2283	c.2119G>A	c.(2119-2121)GCG>ACG	p.A707T	DACT1_uc010trv.1_Missense_Mutation_p.A426T|DACT1_uc001xdx.2_Missense_Mutation_p.A670T|DACT1_uc010trw.1_Missense_Mutation_p.A426T	NM_016651	NP_057735	Q9NYF0	DACT1_HUMAN	dapper 1 isoform 1	707					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				large_intestine(2)|lung(2)|ovary(1)	5						GCTGTACCCCGCGCCTGTGCC	0.672		NaN											0	0	0	0.00308	0	8	79									
SPTB	6710	broad.mit.edu	37	14	65246625	65246625	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr14:65246625G>C	uc001xht.2	-	20	4345	c.4291C>G	c.(4291-4293)CGA>GGA	p.R1431G	SPTB_uc001xhr.2_Missense_Mutation_p.R1431G|SPTB_uc001xhs.2_Missense_Mutation_p.R1431G|SPTB_uc001xhu.2_Missense_Mutation_p.R1431G|SPTB_uc010aqi.2_Missense_Mutation_p.R92G	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	1431	Spectrin 11.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		TCCTCTTTTCGCACATTCACT	0.478		NaN											0	0	0	0.008291	0	10	125									
PTPN21	11099	broad.mit.edu	37	14	88934487	88934487	+	Silent	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr14:88934487G>C	uc001xwv.3	-	19	3850	c.3519C>G	c.(3517-3519)CTC>CTG	p.L1173L	PTPN21_uc010twc.1_Silent_p.L969L	NM_007039	NP_008970	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type	1173						cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			ovary(3)|skin(1)	4						GAGCTTAGATGAGCCTGGAGC	0.468		NaN											0	0	0	0.005524	0	39	247									
TYRO3	7301	broad.mit.edu	37	15	41870164	41870164	+	Missense_Mutation	SNP	A	A	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr15:41870164A>G	uc001zof.1	+	19	2587	c.2363A>G	c.(2362-2364)AAC>AGC	p.N788S		NM_006293	NP_006284	Q06418	TYRO3_HUMAN	TYRO3 protein tyrosine kinase precursor	788	Protein kinase.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			ovary(3)|lung(2)|central_nervous_system(1)	6		all_cancers(109;7.33e-15)|all_epithelial(112;2.8e-12)|Lung NSC(122;3.48e-08)|all_lung(180;1.71e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.31e-18)|GBM - Glioblastoma multiforme(113;9.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.117)		GAACTGGAGAACATCTTGGGC	0.572		NaN											0	0	0	0.009096	0	4	109									
MYO9A	4649	broad.mit.edu	37	15	72172115	72172115	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr15:72172115C>G	uc002atl.3	-	30	6159	c.5686G>C	c.(5686-5688)GCC>CCC	p.A1896P	MYO9A_uc002atk.2_Missense_Mutation_p.A691P|MYO9A_uc002atm.1_Missense_Mutation_p.A692P	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	1896	Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3						TCCTTCAGGGCTTTTTTAAAT	0.373		NaN											0	0	0	0.00308	0	8	58									
CHRNB4	1143	broad.mit.edu	37	15	78922181	78922181	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr15:78922181C>G	uc002bed.1	-	5	578	c.466G>C	c.(466-468)GAG>CAG	p.E156Q	CHRNB4_uc002bee.1_Intron|CHRNB4_uc010blh.1_5'UTR	NM_000750	NP_000741	P30926	ACHB4_HUMAN	cholinergic receptor, nicotinic, beta 4	156	Extracellular (Potential).				regulation of neurotransmitter secretion|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0						TACTTCACCTCAATCTTGCAG	0.567		NaN											0	0	0	0.008291	0	11	74									
MSLN	10232	broad.mit.edu	37	16	816647	816647	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr16:816647C>G	uc002cjw.1	+	13	1285	c.1234C>G	c.(1234-1236)CCT>GCT	p.P412A	MSLN_uc002cjt.1_Intron|MSLN_uc002cju.1_Intron|MSLN_uc010brd.1_Intron|MSLN_uc002cjv.1_Intron|MSLN_uc002cjx.1_Intron|MSLN_uc002cjy.1_Intron	NM_013404	NP_037536	Q13421	MSLN_HUMAN	mesothelin isoform 2 preproprotein	412					cell adhesion	anchored to membrane|extracellular region|Golgi apparatus|plasma membrane				pancreas(1)	1		Hepatocellular(780;0.00335)				CCACAAGGCTCCTCGGCGGCC	0.632		NaN											0	0	0	0.003163	0	16	104									
DOC2A	8448	broad.mit.edu	37	16	30021406	30021406	+	Silent	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr16:30021406G>A	uc002dvm.2	-	2	238	c.138C>T	c.(136-138)GGC>GGT	p.G46G	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|DOC2A_uc002dvl.2_Silent_p.G46G|DOC2A_uc002dvn.2_Silent_p.G46G|DOC2A_uc010vef.1_Intron|DOC2A_uc002dvo.2_Silent_p.G46G|DOC2A_uc002dvp.2_Silent_p.G46G|DOC2A_uc002dvq.2_Silent_p.G46G	NM_003586	NP_003577	Q14183	DOC2A_HUMAN	double C2-like domains, alpha	46	Interaction with UNC13D and DYNLT1.				nervous system development|regulation of calcium ion-dependent exocytosis	cell junction|lysosome|synaptic vesicle membrane|synaptosome	calcium-dependent phospholipid binding|protein binding|transporter activity			ovary(2)	2						cgccgcccccgccgcccccTT	0.567		NaN											0	0	0	0.010729	0	8	60									
ADCY7	113	broad.mit.edu	37	16	50339459	50339459	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr16:50339459C>T	uc002egd.1	+	12	1909	c.1641C>T	c.(1639-1641)GAC>GAT	p.D547D	ADCY7_uc002egc.1_Silent_p.D547D	NM_001114	NP_001105	P51828	ADCY7_HUMAN	adenylate cyclase 7	547	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			skin(1)	1		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	CGTACGATGACGAGATGCTGT	0.597		NaN											0	0	0	0.008871	0	18	179									
CHD9	80205	broad.mit.edu	37	16	53341818	53341818	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr16:53341818G>A	uc002ehb.2	+	32	7170	c.7006G>A	c.(7006-7008)GTG>ATG	p.V2336M	CHD9_uc002egy.2_Splice_Site_p.K2335_splice|CHD9_uc002ehc.2_Splice_Site_p.K2336_splice|CHD9_uc002ehf.2_Splice_Site_p.K1449_splice|CHD9_uc010cbw.2_Missense_Mutation_p.V402M|CHD9_uc002ehg.1_Missense_Mutation_p.V343M	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	2336	Binds A/T-rich DNA.				cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				GATGTCAAAGGTGAAGAAGCA	0.473		NaN											0	0	0	0.000602	0	4	38									
NAE1	8883	broad.mit.edu	37	16	66860670	66860670	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr16:66860670G>A	uc002eqf.2	-	2	144	c.67C>T	c.(67-69)CAT>TAT	p.H23Y	NAE1_uc002eqe.2_Missense_Mutation_p.H17Y|NAE1_uc002eqg.2_Intron|NAE1_uc010cdv.2_Missense_Mutation_p.H23Y|NAE1_uc010cdw.1_Intron	NM_003905	NP_003896	Q13564	ULA1_HUMAN	NEDD8 activating enzyme E1 subunit 1 isoform a	23					apoptosis|cell cycle|DNA replication|mitotic cell cycle DNA replication checkpoint|protein neddylation|signal transduction	cytoplasm|insoluble fraction|plasma membrane	catalytic activity|protein heterodimerization activity			ovary(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0914)|Epithelial(162;0.214)	Adenosine triphosphate(DB00171)	TCTTGCCCATGATCACCCCAC	0.358		NaN											0	0	0	0.006214	0	10	84									
KIAA0895L	653319	broad.mit.edu	37	16	67213339	67213339	+	Nonsense_Mutation	SNP	C	C	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr16:67213339C>A	uc002ert.2	-	4	1616	c.841G>T	c.(841-843)GAG>TAG	p.E281*	KIAA0895L_uc002err.2_5'Flank|KIAA0895L_uc002ers.2_5'UTR|KIAA0895L_uc002eru.2_Nonsense_Mutation_p.E281*|EXOC3L_uc002erv.1_RNA	NM_001040715	NP_001035805	Q68EN5	K895L_HUMAN	hypothetical protein LOC653319	281											0						TGACCTATCTCATGCCGCAGC	0.622		NaN											1	0	3.52763e-06	0.00499	3.71453e-06	13	121									
KIAA0895L	653319	broad.mit.edu	37	16	67213361	67213361	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr16:67213361C>G	uc002ert.2	-	4	1594	c.819G>C	c.(817-819)TGG>TGC	p.W273C	KIAA0895L_uc002err.2_5'Flank|KIAA0895L_uc002ers.2_5'UTR|KIAA0895L_uc002eru.2_Missense_Mutation_p.W273C|EXOC3L_uc002erv.1_RNA	NM_001040715	NP_001035805	Q68EN5	K895L_HUMAN	hypothetical protein LOC653319	273											0						TGCCCTCCAACCAGTACTGGC	0.627		NaN											0	0	0	0.006122	0	11	105									
EXOC3L	283849	broad.mit.edu	37	16	67221161	67221161	+	Missense_Mutation	SNP	G	G	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr16:67221161G>T	uc002erx.1	-	5	1248	c.1007C>A	c.(1006-1008)GCC>GAC	p.A336D	EXOC3L_uc002erv.1_RNA|EXOC3L_uc002erw.1_Intron|EXOC3L_uc002ery.1_Missense_Mutation_p.A280D|EXOC3L_uc010vje.1_Missense_Mutation_p.A275D	NM_178516	NP_848611	Q86VI1	EX3L1_HUMAN	exocyst complex component 3-like	336	Mediates interaction with EXOC2, EXOC4 and EXOC5 (By similarity).				exocytosis|peptide hormone secretion	exocyst|stored secretory granule|transport vesicle					0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0021)|Epithelial(162;0.0073)|all cancers(182;0.0616)		GTGCAGCAAGGCGAAGGCATC	0.627		NaN											1	0	2.17888e-05	0.006214	2.27922e-05	10	67									
DPEP3	64180	broad.mit.edu	37	16	68009821	68009821	+	Silent	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr16:68009821G>A	uc002evc.3	-	10	1483	c.1389C>T	c.(1387-1389)CTC>CTT	p.L463L	DPEP3_uc010cex.2_Silent_p.L462L	NM_022357	NP_071752	Q9H4B8	DPEP3_HUMAN	dipeptidase 3 isoform a	438					meiosis	anchored to membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			breast(3)	3		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0117)|Epithelial(162;0.0481)|all cancers(182;0.236)		TCTGAGGCACGAGGTGGGAGT	0.602		NaN											0	0	0	0.00308	0	7	55									
FUK	197258	broad.mit.edu	37	16	70513198	70513198	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr16:70513198C>T	uc002eyy.2	+	23	3103	c.3045C>T	c.(3043-3045)CAC>CAT	p.H1015H	FUK_uc010cft.2_Silent_p.H1021H|FUK_uc002eyz.2_Silent_p.H506H	NM_145059	NP_659496	Q8N0W3	FUK_HUMAN	fucokinase	1015						cytoplasm	ATP binding|fucokinase activity			ovary(1)	1		Ovarian(137;0.0694)				TGGCCCCCCACGTGCATGGCC	0.632		NaN											0	0	0	0.000602	0	4	75									
MTHFSD	64779	broad.mit.edu	37	16	86565621	86565621	+	Missense_Mutation	SNP	T	T	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr16:86565621T>C	uc002fjn.2	-	8	1199	c.1148A>G	c.(1147-1149)AAG>AGG	p.K383R	MTHFSD_uc010voo.1_Missense_Mutation_p.K363R|MTHFSD_uc002fjo.2_Missense_Mutation_p.K220R|MTHFSD_uc002fjm.2_Missense_Mutation_p.K382R|MTHFSD_uc010vop.1_Missense_Mutation_p.K220R|MTHFSD_uc010voq.1_Missense_Mutation_p.K382R|MTHFSD_uc010vor.1_Missense_Mutation_p.K383R	NM_001159377	NP_001152849	Q2M296	MTHSD_HUMAN	methenyltetrahydrofolate synthetase domain	383					folic acid-containing compound biosynthetic process		5-formyltetrahydrofolate cyclo-ligase activity|ATP binding|RNA binding				0						ACGAGGTCACTTGTCCCTCTG	0.701		NaN											0	0	0	0.004672	0	3	18									
GEMIN4	50628	broad.mit.edu	37	17	649462	649462	+	Silent	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:649462G>C	uc002frs.1	-	2	1940	c.1821C>G	c.(1819-1821)CTC>CTG	p.L607L		NM_015721	NP_056536	P57678	GEMI4_HUMAN	gemin 4	607					rRNA processing|spliceosomal snRNP assembly	Cajal body|cytosol|nucleolus|small nuclear ribonucleoprotein complex|spliceosomal complex	protein binding			ovary(2)|kidney(1)|skin(1)	4		Myeloproliferative disorder(207;0.204)		UCEC - Uterine corpus endometrioid carcinoma (25;0.022)		CGGTTTCTTTGAGGCATGACA	0.502		NaN											0	0	0	0.008871	0	18	150									
PFN1	5216	broad.mit.edu	37	17	4849269	4849269	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:4849269C>G	uc002gaa.2	-	3	485	c.349G>C	c.(349-351)GAA>CAA	p.E117Q	PFN1_uc002fzz.2_Missense_Mutation_p.E81Q	NM_005022	NP_005013	P07737	PROF1_HUMAN	profilin 1	117					actin cytoskeleton organization|platelet activation|platelet degranulation	actin cytoskeleton|cytoplasm	actin binding|proline-rich region binding				0						TGGACACCTTCTTTGCCCATC	0.552		NaN											0	0	0	0.003163	0	15	65									
CAMTA2	23125	broad.mit.edu	37	17	4876139	4876139	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:4876139C>G	uc002gah.1	-	15	2536	c.2428G>C	c.(2428-2430)GAG>CAG	p.E810Q	CAMTA2_uc010cku.1_Missense_Mutation_p.E833Q|CAMTA2_uc002gag.1_Missense_Mutation_p.E809Q|CAMTA2_uc002gai.1_Missense_Mutation_p.E812Q|CAMTA2_uc010ckv.1_Missense_Mutation_p.E457Q	NM_015099	NP_055914	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	810	ANK 3.				cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			ovary(1)	1						TGTAGTTCCTCAAGGCAGCGG	0.612		NaN											0	0	0	0.01441	0	50	164									
FBXO39	162517	broad.mit.edu	37	17	6683806	6683806	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:6683806C>T	uc010vtg.1	+	2	739	c.619C>T	c.(619-621)CAC>TAC	p.H207Y		NM_153230	NP_694962	Q8N4B4	FBX39_HUMAN	F-box protein 39	207										ovary(1)|skin(1)	2						TTTCAGCCATCACCTTGCTGT	0.493		NaN											0	0	0	0.00245	0	15	81									
BCL6B	255877	broad.mit.edu	37	17	6928501	6928501	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:6928501C>T	uc002geg.2	+	5	928	c.871C>T	c.(871-873)CGG>TGG	p.R291W	BCL6B_uc010clt.1_Missense_Mutation_p.R292W	NM_181844	NP_862827	Q8N143	BCL6B_HUMAN	B-cell CLL/lymphoma 6, member B (zinc finger	291						nucleus	zinc ion binding			skin(1)	1						ACCCTCTGAACGGGCTCGTCC	0.557		NaN											0	0	0	0.006214	0	10	158									
NTN1	9423	broad.mit.edu	37	17	8925911	8925911	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:8925911C>T	uc002glw.3	+	2	328	c.221C>T	c.(220-222)CCG>CTG	p.P74L		NM_004822	NP_004813	O95631	NET1_HUMAN	netrin 1 precursor	74	Laminin N-terminal.				apoptosis|axon guidance		protein binding				0						GGCCGGCCCCCGGCGCGCTAC	0.726		NaN											0	0	0	0.004672	0	3	10									
GLP2R	9340	broad.mit.edu	37	17	9729386	9729386	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:9729386G>C	uc002gmd.1	+	1	6	c.6G>C	c.(4-6)AAG>AAC	p.K2N	GLP2R_uc010cog.1_RNA	NM_004246	NP_004237	O95838	GLP2R_HUMAN	glucagon-like peptide 2 receptor precursor	2	Extracellular (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of cell proliferation	integral to membrane|plasma membrane				lung(2)|ovary(1)	3					Glucagon recombinant(DB00040)	GGAAGATGAAGCTGGGATCGA	0.632		NaN											0	0	0	0.001984	0	6	26									
KRTAP1-1	81851	broad.mit.edu	37	17	39197393	39197393	+	Missense_Mutation	SNP	T	T	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:39197393T>C	uc002hvw.1	-	1	321	c.257A>G	c.(256-258)TAC>TGC	p.Y86C		NM_030967	NP_112229	Q07627	KRA11_HUMAN	keratin associated protein 1-1	86			Missing (in allele KAP1.7).			extracellular region|keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			GCTGGTCTGGTAGCAGCTTGG	0.587		NaN											0	0	0	0.009096	0	4	124									
HDAC5	10014	broad.mit.edu	37	17	42171034	42171034	+	Missense_Mutation	SNP	T	T	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:42171034T>A	uc002ifd.1	-	4	474	c.263A>T	c.(262-264)CAG>CTG	p.Q88L	HDAC5_uc002ife.1_Missense_Mutation_p.Q88L|HDAC5_uc002iff.1_Missense_Mutation_p.Q89L|HDAC5_uc010czp.1_Missense_Mutation_p.Q88L|HDAC5_uc002ifh.2_Missense_Mutation_p.Q88L	NM_005474	NP_005465	Q9UQL6	HDAC5_HUMAN	histone deacetylase 5 isoform 1	88	Poly-Gln.				B cell differentiation|cellular response to insulin stimulus|chromatin remodeling|chromatin silencing|inflammatory response|negative regulation of cell migration involved in sprouting angiogenesis|negative regulation of myotube differentiation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			ovary(1)	1		Breast(137;0.00637)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.118)		cttctgcagctgctgctgctg	0.408		NaN											0	0	0	0.004672	0	3	32									
XYLT2	64132	broad.mit.edu	37	17	48431297	48431297	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:48431297G>C	uc002iqo.2	+	2	551	c.442G>C	c.(442-444)GAG>CAG	p.E148Q	XYLT2_uc010dbo.2_RNA	NM_022167	NP_071450	Q9H1B5	XYLT2_HUMAN	xylosyltransferase II	148	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			pancreas(1)	1	Breast(11;7.18e-19)					AGGGAGCGTGGAGGGCGCCCC	0.692		NaN											0	0	0	0.004482	0	9	47									
NACA2	342538	broad.mit.edu	37	17	59668370	59668370	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:59668370C>T	uc002izj.2	-	1	198	c.172G>A	c.(172-174)GAA>AAA	p.E58K		NM_199290	NP_954984	Q9H009	NACA2_HUMAN	nascent-polypeptide-associated complex alpha	58					protein transport	cytoplasm|nucleus				ovary(1)	1	all_epithelial(1;3.12e-14)					TCATCAATTTCAGCTGCTGCC	0.493		NaN											0	0	0	0.003755	0	37	165									
H3F3B	3021	broad.mit.edu	37	17	73774687	73774687	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:73774687C>G	uc002jpl.2	-	4	533	c.400G>C	c.(400-402)GAG>CAG	p.E134Q		NM_005324	NP_005315	P84243	H33_HUMAN	H3 histone, family 3B	134					blood coagulation|nucleosome assembly	nucleoplasm|nucleosome	DNA binding			ovary(1)	1	all_cancers(13;1.5e-07)		all cancers(21;2.61e-06)|Epithelial(20;7.39e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|LUSC - Lung squamous cell carcinoma(166;0.154)			TAAGCTCTCTCTCCCCGTATC	0.418		NaN											0	0	0	0.010818	0	32	132									
UNC13D	201294	broad.mit.edu	37	17	73824054	73824054	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:73824054C>T	uc002jpp.2	-	32	3645	c.3265G>A	c.(3265-3267)GCA>ACA	p.A1089T		NM_199242	NP_954712	Q70J99	UN13D_HUMAN	unc-13 homolog D	1089					positive regulation of exocytosis|regulation of mast cell degranulation	exocytic vesicle|late endosome|lysosome|membrane|recycling endosome	protein binding			upper_aerodigestive_tract(1)|skin(1)	2			all cancers(21;2.11e-06)|Epithelial(20;2.32e-06)|BRCA - Breast invasive adenocarcinoma(9;0.000618)|LUSC - Lung squamous cell carcinoma(166;0.154)			GGCTACGGTGCCGGCCGCAAG	0.697		NaN							Familial_Hemophagocytic_Lymphohistiocytosis				0	0	0	0.004672	0	3	24									
TMC6	11322	broad.mit.edu	37	17	76120607	76120607	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:76120607C>T	uc002juj.1	-	7	1015	c.889G>A	c.(889-891)GCG>ACG	p.A297T	TMC6_uc002jui.1_5'Flank|TMC6_uc010dhf.1_Missense_Mutation_p.A130T|TMC6_uc002juk.2_Missense_Mutation_p.A297T|TMC6_uc010dhg.1_Missense_Mutation_p.A297T|TMC6_uc002jul.1_Missense_Mutation_p.A297T|TMC6_uc002jum.3_Missense_Mutation_p.A88T|TMC6_uc002jun.3_Missense_Mutation_p.A297T|TMC6_uc002juo.2_Missense_Mutation_p.A70T|TMC6_uc010wtp.1_Missense_Mutation_p.A130T	NM_007267	NP_009198	Q7Z403	TMC6_HUMAN	transmembrane channel-like 6	297	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			TTCCTCACCGCGCCTGTGAGG	0.697		NaN							Epidermodysplasia_Verruciformis_Familial_Clustering_of				0	0	0	0.001984	0	6	38									
BAHCC1	57597	broad.mit.edu	37	17	79426591	79426591	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:79426591C>G	uc002kaf.2	+	21	5866	c.5866C>G	c.(5866-5868)CAG>GAG	p.Q1956E	BAHCC1_uc002kae.2_Missense_Mutation_p.Q1186E	NM_001080519	NP_001073988	Q9P281	BAHC1_HUMAN	BAH domain and coiled-coil containing 1	1956							DNA binding			ovary(1)	1	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0224)|OV - Ovarian serous cystadenocarcinoma(97;0.116)			CTACTGGAGTCAGAAGTCTCG	0.657		NaN											0	0	0	0.003163	0	14	98									
FSCN2	25794	broad.mit.edu	37	17	79503966	79503966	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:79503966G>C	uc010wup.1	+	5	1480	c.1339G>C	c.(1339-1341)GAG>CAG	p.E447Q	FSCN2_uc010wuo.1_Missense_Mutation_p.E471Q	NM_012418	NP_036550	O14926	FSCN2_HUMAN	fascin 2 isoform 1	447					actin filament bundle assembly|anatomical structure morphogenesis|visual perception	actin cytoskeleton|cytoplasm|stereocilium	actin filament binding|protein binding, bridging				0	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)			CGAACGCGCCGAGGACTTCGT	0.761		NaN											0	0	0	0.001168	0	6	14									
ENOSF1	55556	broad.mit.edu	37	18	691231	691231	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr18:691231C>T	uc002kku.3	-	6	544	c.469G>A	c.(469-471)GAT>AAT	p.D157N	ENOSF1_uc002kkt.3_Missense_Mutation_p.D75N|ENOSF1_uc010dke.2_RNA|ENOSF1_uc010dkf.2_Missense_Mutation_p.D178N|ENOSF1_uc002kkv.3_Missense_Mutation_p.D157N|ENOSF1_uc002kkw.3_Intron|ENOSF1_uc002kkx.3_Intron|ENOSF1_uc010wyt.1_RNA	NM_017512	NP_059982	Q7L5Y1	ENOF1_HUMAN	enolase superfamily 1 isoform rTS beta	157					cellular amino acid catabolic process	mitochondrion	isomerase activity|metal ion binding			ovary(1)	1						GTCAGGACATCAGTGATGTAC	0.483		NaN											0	0	0	0.001168	0	5	83									
LAMA3	3909	broad.mit.edu	37	18	21427492	21427492	+	Silent	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr18:21427492G>A	uc002kuq.2	+	32	4082	c.3996G>A	c.(3994-3996)ACG>ACA	p.T1332T	LAMA3_uc002kur.2_Silent_p.T1332T	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	1332	Laminin EGF-like 10.|Domain III B.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTCCCCGCACGGTCAGGCCCC	0.622		NaN											0	0	0	0.00308	0	8	78									
SMAD7	4092	broad.mit.edu	37	18	46476250	46476250	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr18:46476250G>C	uc002ldg.2	-	1	832	c.545C>G	c.(544-546)TCT>TGT	p.S182C	SMAD7_uc010xde.1_5'Flank	NM_005904	NP_005895	O15105	SMAD7_HUMAN	SMAD family member 7	182	MH1.				adherens junction assembly|artery morphogenesis|BMP signaling pathway|cellular protein complex localization|negative regulation of BMP signaling pathway|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of peptidyl-serine phosphorylation|negative regulation of peptidyl-threonine phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription by competitive promoter binding|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity|pathway-restricted SMAD protein phosphorylation|positive regulation of anti-apoptosis|positive regulation of cell-cell adhesion|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein stabilization|regulation of activin receptor signaling pathway|response to laminar fluid shear stress|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	centrosome|cytosol|nucleolus|plasma membrane|transcription factor complex	activin binding|beta-catenin binding|I-SMAD binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity|type I transforming growth factor beta receptor binding|ubiquitin protein ligase binding				0	Colorectal(1;0.0518)					CTTCCCGTAAGATTCACAGCA	0.572		NaN									OREG0024975	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000602	0	5	53									
KCNG2	26251	broad.mit.edu	37	18	77659423	77659423	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr18:77659423C>T	uc010xfl.1	+	2	1008	c.1008C>T	c.(1006-1008)TTC>TTT	p.F336F		NM_012283	NP_036415	Q9UJ96	KCNG2_HUMAN	potassium voltage-gated channel, subfamily G,	336	Helical; Name=Segment S5; (Potential).				energy reserve metabolic process|regulation of heart contraction|regulation of insulin secretion	voltage-gated potassium channel complex	delayed rectifier potassium channel activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;6.92e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0244)		TGGCGCTCTTCGCGCCACTGG	0.716		NaN											0	0	0	0.000602	0	5	11									
SGTA	6449	broad.mit.edu	37	19	2762518	2762518	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:2762518C>T	uc002lwi.1	-	7	769	c.622G>A	c.(622-624)GAG>AAG	p.E208K		NM_003021	NP_003012	O43765	SGTA_HUMAN	small glutamine-rich tetratricopeptide	208					interspecies interaction between organisms	cytoplasm	protein binding			ovary(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGGGGGCCTCCCGCAGCTTC	0.647		NaN											0	0	0	0.010729	0	12	111									
LRG1	116844	broad.mit.edu	37	19	4538457	4538457	+	Missense_Mutation	SNP	G	G	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:4538457G>T	uc002mau.2	-	2	550	c.539C>A	c.(538-540)CCC>CAC	p.P180H	PLIN5_uc002mat.1_Intron	NM_052972	NP_443204	P02750	A2GL_HUMAN	leucine-rich alpha-2-glycoprotein 1 precursor	180	LRR 4.					extracellular region|membrane				ovary(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGCCCGGGGGGCAGTTTCCG	0.622		NaN											1	0	1.96895e-08	0.00278	2.11529e-08	25	265									
FBN3	84467	broad.mit.edu	37	19	8152753	8152753	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:8152753C>G	uc002mjf.2	-	52	6596	c.6575G>C	c.(6574-6576)TGT>TCT	p.C2192S	FBN3_uc002mje.2_Missense_Mutation_p.C31S	NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	2192	EGF-like 35; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						GCCGGCTGGACAGGTGCACAG	0.453		NaN											0	0	0	0.013537	0	12	157									
MYO1F	4542	broad.mit.edu	37	19	8591788	8591788	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:8591788C>G	uc002mkg.2	-	23	2620	c.2506G>C	c.(2506-2508)GAG>CAG	p.E836Q		NM_012335	NP_036467	O00160	MYO1F_HUMAN	myosin IF	836						unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(1)	3						GCGGCATCCTCTTGGAGGATG	0.627		NaN											0	0	0	0.000602	0	5	63									
ZNF846	162993	broad.mit.edu	37	19	9868414	9868414	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:9868414C>T	uc002mmb.1	-	6	1870	c.1339G>A	c.(1339-1341)GAA>AAA	p.E447K	ZNF846_uc010xky.1_Intron|ZNF846_uc010xkz.1_Intron|ZNF846_uc010dww.2_Intron|ZNF846_uc002mmc.1_Missense_Mutation_p.E318K	NM_001077624	NP_001071092	Q147U1	ZN846_HUMAN	zinc finger protein 846	447					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CAGGCCTTTTCTCCAGTGTGA	0.438		NaN											0	0	0	0.00499	0	17	69									
TYK2	7297	broad.mit.edu	37	19	10475384	10475384	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:10475384G>A	uc002moc.3	-	9	1651	c.1273C>T	c.(1273-1275)CGC>TGC	p.R425C	TYK2_uc010dxe.2_Missense_Mutation_p.R240C|TYK2_uc002mod.2_Missense_Mutation_p.R425C	NM_003331	NP_003322	P29597	TYK2_HUMAN	tyrosine kinase 2	425	FERM.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|large_intestine(2)|ovary(1)|breast(1)	9			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			GCCGTCAGGCGGAAATAGCCG	0.672		NaN											0	0	0	0.014323	0	22	79									
ARRDC2	27106	broad.mit.edu	37	19	18120728	18120728	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:18120728C>T	uc002nhv.2	+	5	872	c.729C>T	c.(727-729)CTC>CTT	p.L243L	ARRDC2_uc002nhu.2_Silent_p.L238L	NM_015683	NP_056498	Q8TBH0	ARRD2_HUMAN	arrestin domain containing 2 isoform 1	243										pancreas(1)	1						TGGCCAGCCTCGCGGGCGAGC	0.716		NaN											0	0	0	0.00308	0	8	96									
ARHGAP33	115703	broad.mit.edu	37	19	36278974	36278974	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:36278974C>T	uc002obs.1	+	21	3109	c.3024C>T	c.(3022-3024)TAC>TAT	p.Y1008Y	ARHGAP33_uc002obt.1_Silent_p.Y1005Y|ARHGAP33_uc010eel.2_Intron|ARHGAP33_uc002obv.1_Silent_p.Y757Y	NM_052948	NP_443180	O14559	RHG33_HUMAN	sorting nexin 26	1169					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			skin(2)|ovary(1)|pancreas(1)	4						AGCCCCTCTACGTCAACCTAG	0.682		NaN											0	0	0	0.003163	0	15	80									
LIPE	3991	broad.mit.edu	37	19	42910494	42910494	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:42910494C>T	uc002otr.2	-	7	2461	c.2184G>A	c.(2182-2184)GGG>GGA	p.G728G	uc010eif.1_Intron	NM_005357	NP_005348	Q05469	LIPS_HUMAN	hormone-sensitive lipase	728					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			ovary(1)|breast(1)	2		Prostate(69;0.00682)				AGCAGAGGTTCCCGCCTGCAC	0.662		NaN											0	0	0	0.001984	0	7	42									
NKPD1	284353	broad.mit.edu	37	19	45656023	45656023	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:45656023G>A	uc010xxi.1	-	4	1672	c.1672C>T	c.(1672-1674)CGC>TGC	p.R558C		NM_198478	NP_940880			NTPase, KAP family P-loop domain containing 1												0		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00863)|GBM - Glioblastoma multiforme(486;0.231)		CACGGCTTGCGCGTCATCTCG	0.721		NaN											0	0	0	0.001168	0	5	16									
CCDC9	26093	broad.mit.edu	37	19	47773835	47773835	+	Silent	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:47773835G>A	uc010xym.1	+	10	1182	c.975G>A	c.(973-975)CCG>CCA	p.P325P		NM_015603	NP_056418	Q9Y3X0	CCDC9_HUMAN	coiled-coil domain containing 9	325											0		all_cancers(25;0.0432)|all_epithelial(76;0.00812)|Medulloblastoma(540;0.0208)|all_neural(266;0.0416)|Hepatocellular(1079;0.114)		OV - Ovarian serous cystadenocarcinoma(262;8.51e-95)|Epithelial(262;1.15e-92)|all cancers(93;7.67e-84)|GBM - Glioblastoma multiforme(486;0.024)|STAD - Stomach adenocarcinoma(1328;0.183)		CCCGGCCCCCGAAGCCCCCTA	0.642		NaN											0	0	0	0.010729	0	9	109									
SIGLEC9	27180	broad.mit.edu	37	19	51628543	51628543	+	Silent	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:51628543G>A	uc002pvu.2	+	1	379	c.312G>A	c.(310-312)CTG>CTA	p.L104L	SIGLEC9_uc010yct.1_Silent_p.L104L	NM_014441	NP_055256	Q9Y336	SIGL9_HUMAN	sialic acid binding Ig-like lectin 9 precursor	104	Extracellular (Potential).|Ig-like V-type.				cell adhesion|cell surface receptor linked signaling pathway	integral to plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000826)|OV - Ovarian serous cystadenocarcinoma(262;0.00295)		ATTGCACCCTGAGCATCAGAG	0.507		NaN											0	0	0	0.006122	0	19	115									
ZNF524	147807	broad.mit.edu	37	19	56113573	56113573	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:56113573G>A	uc002qlk.1	+	2	178	c.95G>A	c.(94-96)CGA>CAA	p.R32Q	FIZ1_uc002qli.3_5'Flank|FIZ1_uc002qlj.3_5'Flank	NM_153219	NP_694951	Q96C55	ZN524_HUMAN	zinc finger protein 524	32					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)		CGGGGCCGCCGAGGCCGTCGT	0.682		NaN											0	0	0	0.00308	0	8	45									
PEG3	5178	broad.mit.edu	37	19	57335705	57335705	+	Silent	SNP	G	G	T	rs141346770	by1000genomes	TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:57335705G>T	uc002qnu.2	-	1	670	c.319C>A	c.(319-321)CGA>AGA	p.R107R	ZIM2_uc010ygq.1_5'UTR|ZIM2_uc010ygr.1_5'UTR|ZIM2_uc002qnr.2_5'UTR|ZIM2_uc002qnq.2_5'UTR|ZIM2_uc010etp.2_5'UTR|ZIM2_uc010ygs.1_5'UTR|PEG3_uc002qnt.2_Silent_p.R107R|PEG3_uc002qnv.2_Silent_p.R107R|PEG3_uc002qnw.2_5'UTR|PEG3_uc002qnx.2_5'UTR|PEG3_uc010etr.2_Silent_p.R107R	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	107	SCAN box.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TTTTTTGCTCGCACCCAAGGC	0.537		NaN											1	0	0.00136819	0.013537	0.00140804	13	154									
ZNF551	90233	broad.mit.edu	37	19	58198725	58198725	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:58198725G>A	uc002qpw.3	+	3	1257	c.1034G>A	c.(1033-1035)AGG>AAG	p.R345K	ZNF551_uc002qpv.3_Missense_Mutation_p.R288K|ZNF776_uc002qpx.2_Intron	NM_138347	NP_612356	Q7Z340	ZN551_HUMAN	zinc finger protein 551	361					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		ACTGGAGAAAGGCCTTATGAA	0.468		NaN											0	0	0	0.010729	0	11	141									
ZNF329	79673	broad.mit.edu	37	19	58639742	58639742	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:58639742C>T	uc002qrn.2	-	4	1366	c.1129G>A	c.(1129-1131)GGG>AGG	p.G377R	ZNF329_uc010euk.1_RNA|ZNF329_uc002qro.1_RNA|ZNF329_uc002qrp.1_RNA	NM_024620	NP_078896	Q86UD4	ZN329_HUMAN	zinc finger protein 329	377	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.029)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)|Lung(386;0.216)		AAGGATTTCCCGCACTCTGCA	0.478		NaN											0	0	0	0.013537	0	12	137									
TRIB2	28951	broad.mit.edu	37	2	12863643	12863643	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:12863643C>T	uc002rbv.3	+	2	1964	c.528C>T	c.(526-528)CTC>CTT	p.L176L	TRIB2_uc010yjp.1_Silent_p.L40L	NM_021643	NP_067675	Q92519	TRIB2_HUMAN	tribbles homolog 2	176	Protein kinase.				negative regulation of fat cell differentiation|negative regulation of interleukin-10 biosynthetic process|negative regulation of protein kinase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of MAP kinase activity	cytoplasm|cytoskeleton|nucleus	ATP binding|protein kinase activity|protein kinase inhibitor activity|transcription factor binding|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			stomach(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					TGCGGGACCTCAAGCTGCGGA	0.562		NaN											0	0	0	0.013537	0	12	89									
APOB	338	broad.mit.edu	37	2	21229266	21229266	+	Missense_Mutation	SNP	T	T	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:21229266T>A	uc002red.2	-	26	10602	c.10474A>T	c.(10474-10476)ATT>TTT	p.I3492F		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3492	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GATGACTCAATGGAAAAGTAA	0.418		NaN											0	0	0	0.006122	0	19	83									
KRTCAP3	200634	broad.mit.edu	37	2	27665507	27665507	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:27665507C>T	uc002rks.2	+	2	107	c.90C>T	c.(88-90)CAC>CAT	p.H30H	KRTCAP3_uc010ylr.1_Silent_p.H30H|KRTCAP3_uc002rkt.2_Silent_p.H12H	NM_173853	NP_776252	Q53RY4	KCP3_HUMAN	keratinocyte associated protein 3	30	Helical; (Potential).					integral to membrane					0	Acute lymphoblastic leukemia(172;0.155)					TGGTGGGCCACGTGAACCTGC	0.597		NaN											0	0	0	0.001168	0	6	27									
FAM179A	165186	broad.mit.edu	37	2	29268244	29268244	+	Missense_Mutation	SNP	G	G	A	rs150801790		TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:29268244G>A	uc010ezl.2	+	19	3041	c.2690G>A	c.(2689-2691)CGT>CAT	p.R897H	FAM179A_uc010ymm.1_Missense_Mutation_p.R842H|FAM179A_uc002rmr.3_Missense_Mutation_p.R424H|FAM179A_uc002rms.1_Missense_Mutation_p.R195H	NM_199280	NP_954974	Q6ZUX3	F179A_HUMAN	hypothetical protein LOC165186	897							binding			ovary(3)|skin(1)	4						CTGAGTGGCCGTGCGGTGCTG	0.612		NaN											0	0	0	0.010504	0	19	102									
NLRC4	58484	broad.mit.edu	37	2	32476278	32476278	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:32476278G>C	uc002roi.2	-	4	901	c.655C>G	c.(655-657)CAA>GAA	p.Q219E	NLRC4_uc002roj.1_Missense_Mutation_p.Q219E|NLRC4_uc010ezt.1_Intron	NM_021209	NP_067032	Q9NPP4	NLRC4_HUMAN	caspase recruitment domain protein 12	219	NACHT.				activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			ovary(3)|large_intestine(1)|lung(1)|skin(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					TCCAGGAGTTGATCACAGAGG	0.517		NaN											0	0	0	0.00245	0	15	71									
CCDC88A	55704	broad.mit.edu	37	2	55566659	55566659	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:55566659C>G	uc002ryv.2	-	13	2301	c.1459G>C	c.(1459-1461)GAA>CAA	p.E487Q	CCDC88A_uc010yoz.1_Missense_Mutation_p.E487Q|CCDC88A_uc010ypa.1_Missense_Mutation_p.E487Q|CCDC88A_uc010ypb.1_Missense_Mutation_p.E389Q	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	487	Potential.				activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						GCATTGCCTTCTACAGAATCC	0.323		NaN											0	0	0	0.000602	0	5	61									
HK2	3099	broad.mit.edu	37	2	75116424	75116424	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:75116424G>C	uc002snd.2	+	17	4354	c.2428G>C	c.(2428-2430)GAG>CAG	p.E810Q		NM_000189	NP_000180	P52789	HXK2_HUMAN	hexokinase 2	810	Catalytic.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			ovary(1)|lung(1)	2						CTTAGGGCTTGAGAGCACCTG	0.617		NaN											0	0	0	0.004482	0	8	44									
REG1A	5967	broad.mit.edu	37	2	79348757	79348757	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:79348757C>T	uc002snz.2	+	3	237	c.134C>T	c.(133-135)TCC>TTC	p.S45F	REG1A_uc010ffx.1_Missense_Mutation_p.S45F|REG1A_uc010ysd.1_Missense_Mutation_p.S45F	NM_002909	NP_002900	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha precursor	45	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding				0						GCCTATCGCTCCTACTGCTAC	0.542		NaN											0	0	0	0.006214	0	10	480									
VWA3B	200403	broad.mit.edu	37	2	98804557	98804557	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:98804557G>C	uc002syo.2	+	10	1695	c.1431G>C	c.(1429-1431)GAG>GAC	p.E477D	VWA3B_uc010yvh.1_Missense_Mutation_p.E327D|VWA3B_uc002syj.2_RNA|VWA3B_uc002syk.1_Intron|VWA3B_uc002syl.1_Intron|VWA3B_uc002sym.2_Missense_Mutation_p.E477D|VWA3B_uc002syn.1_Intron|VWA3B_uc010yvi.1_Missense_Mutation_p.E134D	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	477										ovary(3)|large_intestine(2)|skin(1)	6						GGTACAGTGAGAGAATCCACA	0.502		NaN											0	0	0	0.010504	0	20	95									
LONRF2	164832	broad.mit.edu	37	2	100903525	100903525	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:100903525C>T	uc002tal.3	-	11	2561	c.1921G>A	c.(1921-1923)GTG>ATG	p.V641M	LONRF2_uc010yvs.1_RNA	NM_198461	NP_940863	Q1L5Z9	LONF2_HUMAN	LON peptidase N-terminal domain and ring finger	641	Lon.				proteolysis		ATP-dependent peptidase activity|zinc ion binding			large_intestine(1)|skin(1)	2						GGACCCTCCACCTGATCAGGG	0.507		NaN											0	0	0	0.001168	0	5	41									
BUB1	699	broad.mit.edu	37	2	111408235	111408235	+	Silent	SNP	A	A	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:111408235A>G	uc002tgc.2	-	18	2203	c.2091T>C	c.(2089-2091)GCT>GCC	p.A697A	BUB1_uc010yxh.1_Silent_p.A677A|BUB1_uc010fkb.2_Silent_p.A697A	NM_004336	NP_004327	O43683	BUB1_HUMAN	budding uninhibited by benzimidazoles 1	697					apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|breast(2)|stomach(1)|ovary(1)|kidney(1)	7		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		TGAGTCTGCAAGCCTCAACGC	0.537		NaN											0	0	0	0.009096	0	4	39									
BUB1	699	broad.mit.edu	37	2	111408294	111408294	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:111408294G>C	uc002tgc.2	-	18	2144	c.2032C>G	c.(2032-2034)CTG>GTG	p.L678V	BUB1_uc010yxh.1_Missense_Mutation_p.L658V|BUB1_uc010fkb.2_Missense_Mutation_p.L678V	NM_004336	NP_004327	O43683	BUB1_HUMAN	budding uninhibited by benzimidazoles 1	678					apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|breast(2)|stomach(1)|ovary(1)|kidney(1)	7		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		GGCTGGCTCAGACGAAGTAAG	0.502		NaN											0	0	0	0.004672	0	3	48									
CNTNAP5	129684	broad.mit.edu	37	2	125671724	125671724	+	Silent	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:125671724G>C	uc002tno.2	+	24	4144	c.3780G>C	c.(3778-3780)CGG>CGC	p.R1260R	CNTNAP5_uc010flu.2_Silent_p.R1261R	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	1260	Cytoplasmic (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		TCATGACCCGGTTCCTCTACC	0.453		NaN											0	0	0	0.004482	0	8	160									
SAP130	79595	broad.mit.edu	37	2	128767935	128767935	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:128767935G>C	uc002tpp.2	-	7	987	c.855C>G	c.(853-855)ATC>ATG	p.I285M	SAP130_uc002tpn.2_Missense_Mutation_p.I46M|SAP130_uc002tpo.2_Missense_Mutation_p.I30M|SAP130_uc010fmd.2_Missense_Mutation_p.I285M|SAP130_uc002tpq.1_Missense_Mutation_p.I259M	NM_024545	NP_078821	Q9H0E3	SP130_HUMAN	Sin3A-associated protein, 130kDa isoform b	285					histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			ovary(2)|skin(2)	4	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0771)		CAGCAGGAGGGATGGCATTGG	0.448		NaN											0	0	0	0.009096	0	4	94									
XIRP2	129446	broad.mit.edu	37	2	168101899	168101899	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:168101899G>C	uc002udx.2	+	8	4015	c.3997G>C	c.(3997-3999)GAA>CAA	p.E1333Q	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.E1158Q|XIRP2_uc010fpq.2_Missense_Mutation_p.E1111Q|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1158					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GTCCTATCATGAAGTGACCAC	0.383		NaN											0	0	0	0.006214	0	10	60									
LRP2	4036	broad.mit.edu	37	2	170055326	170055326	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:170055326C>G	uc002ues.2	-	45	8761	c.8548G>C	c.(8548-8550)GAT>CAT	p.D2850H		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	2850	LDL-receptor class A 19.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TCACTGTTATCTCCACAGTCA	0.378		NaN											0	0	0	0.009096	0	3	38									
SGOL2	151246	broad.mit.edu	37	2	201436243	201436243	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:201436243G>A	uc002uvw.2	+	7	1287	c.1174G>A	c.(1174-1176)GAA>AAA	p.E392K	SGOL2_uc010zhd.1_Missense_Mutation_p.E392K|SGOL2_uc010zhe.1_Missense_Mutation_p.E392K	NM_152524	NP_689737	Q562F6	SGOL2_HUMAN	shugoshin-like 2 isoform 1	392					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			ovary(2)|skin(2)	4						AAAAACAAATGAACATGGAAT	0.318		NaN											0	0	0	0.001168	0	6	56									
CUL3	8452	broad.mit.edu	37	2	225371615	225371615	+	Missense_Mutation	SNP	G	G	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:225371615G>T	uc002vny.2	-	7	1373	c.989C>A	c.(988-990)TCT>TAT	p.S330Y	CUL3_uc010zls.1_Missense_Mutation_p.S264Y|CUL3_uc010fwy.1_Missense_Mutation_p.S336Y	NM_003590	NP_003581	Q13618	CUL3_HUMAN	cullin 3	330					cell cycle arrest|cell migration|cyclin catabolic process|cytokinesis|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|mitotic anaphase|negative regulation of Rho protein signal transduction|positive regulation of cell proliferation|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|Golgi apparatus|nucleus|polar microtubule	ubiquitin protein ligase binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|kidney(1)	4		all_lung(227;0.00877)|Lung NSC(271;0.011)|Renal(207;0.0112)|all_hematologic(139;0.138)		Epithelial(121;1.58e-11)|all cancers(144;1.43e-08)|Lung(261;0.00863)|LUSC - Lung squamous cell carcinoma(224;0.00902)		TCCTTCTTCAGAAACAAGAGC	0.378		NaN											1	0	0.00307968	0.00308	0.00312888	8	45									
HDLBP	3069	broad.mit.edu	37	2	242169088	242169088	+	Silent	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:242169088G>A	uc002waz.2	-	28	3963	c.3735C>T	c.(3733-3735)AGC>AGT	p.S1245S	HDLBP_uc002wba.2_Silent_p.S1245S|HDLBP_uc002wbb.2_Silent_p.S1197S	NM_203346	NP_976221	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	1245					cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(3)|skin(1)	4		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		CCTCAGAGCTGCTCATGTCAG	0.582		NaN											0	0	0	0.001984	0	6	43									
ProSAPiP1	9762	broad.mit.edu	37	20	3146671	3146671	+	Silent	SNP	A	A	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr20:3146671A>C	uc002wia.1	-	2	2193	c.795T>G	c.(793-795)GGT>GGG	p.G265G	ProSAPiP1_uc002wib.1_Silent_p.G265G	NM_014731	NP_055546	O60299	PRIP1_HUMAN	ProSAPiP1 protein	265						cell junction|cytoplasm|postsynaptic density|postsynaptic membrane				pancreas(1)	1						CCGACCCCCCACCGCTGCTGC	0.657		NaN											0	0	0	0.008871	0	6	46									
C20orf194	25943	broad.mit.edu	37	20	3270794	3270794	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr20:3270794G>C	uc002wii.2	-	26	2359	c.2308C>G	c.(2308-2310)CTG>GTG	p.L770V	C20orf194_uc002wij.3_Missense_Mutation_p.L509V|C20orf194_uc002wik.2_Missense_Mutation_p.L444V	NM_001009984	NP_001009984	Q5TEA3	CT194_HUMAN	hypothetical protein LOC25943	770											0						TCCTTATGCAGAGTGACCAGA	0.478		NaN											0	0	0	0.009718	0	42	310									
KIF16B	55614	broad.mit.edu	37	20	16359644	16359644	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr20:16359644C>G	uc002wpg.1	-	19	3161	c.3003G>C	c.(3001-3003)CAG>CAC	p.Q1001H	KIF16B_uc002wpe.1_Missense_Mutation_p.Q383H|KIF16B_uc002wpf.1_Missense_Mutation_p.Q383H|KIF16B_uc010gch.1_Missense_Mutation_p.Q1001H|KIF16B_uc010gci.1_Missense_Mutation_p.Q1001H|KIF16B_uc010gcj.1_Missense_Mutation_p.Q1012H	NM_024704	NP_078980	Q96L93	KI16B_HUMAN	kinesin-like motor protein C20orf23	1001	Glu-rich.|Potential.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			skin(2)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|ovary(1)|kidney(1)	8						GCGCCTCTCTCTGCTGCTTCT	0.552		NaN											0	0	0	0.00499	0	18	164									
NINL	22981	broad.mit.edu	37	20	25456923	25456923	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr20:25456923C>T	uc002wux.1	-	17	3078	c.3004G>A	c.(3004-3006)GAG>AAG	p.E1002K	NINL_uc010gdn.1_Intron	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	1002					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						AGGGCGCCCTCGGCCCGGGCC	0.677		NaN											0	0	0	0.013537	0	12	94									
WFDC3	140686	broad.mit.edu	37	20	44416554	44416554	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr20:44416554C>G	uc002xpf.1	-	4	363	c.279G>C	c.(277-279)GAG>GAC	p.E93D	WFDC3_uc002xpj.1_RNA|WFDC3_uc002xph.1_RNA|WFDC3_uc010ghh.1_RNA	NM_080614	NP_542181	Q8IUB2	WFDC3_HUMAN	WAP four-disulfide core domain 3 precursor	93	WAP 2.					extracellular region	serine-type endopeptidase inhibitor activity				0		Myeloproliferative disorder(115;0.0122)				CTGGACATGTCTCATCAGTGA	0.463		NaN											0	0	0	0.001168	0	6	73									
WFDC3	140686	broad.mit.edu	37	20	44417657	44417657	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr20:44417657C>G	uc002xpf.1	-	3	208	c.124G>C	c.(124-126)GAG>CAG	p.E42Q	DNTTIP1_uc002xpk.2_5'Flank|WFDC3_uc002xpj.1_RNA|WFDC3_uc002xph.1_RNA|WFDC3_uc010ghh.1_Intron	NM_080614	NP_542181	Q8IUB2	WFDC3_HUMAN	WAP four-disulfide core domain 3 precursor	42	WAP 1.					extracellular region	serine-type endopeptidase inhibitor activity				0		Myeloproliferative disorder(115;0.0122)				TGGCACAGCTCTTTGCATGGG	0.512		NaN											0	0	0	0.006122	0	16	249									
CTCFL	140690	broad.mit.edu	37	20	56098314	56098314	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr20:56098314C>T	uc010gix.1	-	2	1226	c.564G>A	c.(562-564)AAG>AAA	p.K188K	CTCFL_uc010giw.1_Silent_p.K188K|CTCFL_uc002xym.2_Silent_p.K188K|CTCFL_uc010giz.1_Intron|CTCFL_uc010giy.1_Intron|CTCFL_uc010gja.1_Silent_p.K188K|CTCFL_uc010gjb.1_Silent_p.K188K|CTCFL_uc010gjc.1_Silent_p.K188K|CTCFL_uc010gjd.1_Silent_p.K188K|CTCFL_uc010gje.2_Silent_p.K188K|CTCFL_uc010gjf.2_5'UTR|CTCFL_uc010gjg.2_Intron|CTCFL_uc010gjh.1_Silent_p.K188K|CTCFL_uc010gji.1_5'UTR|CTCFL_uc010gjj.1_Silent_p.K188K|CTCFL_uc010gjk.1_Silent_p.K188K|CTCFL_uc010gjl.1_Silent_p.K188K	NM_080618	NP_542185	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor-like protein	188					cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|skin(1)	4	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			ATAACTGGTTCTTCTCCTGCT	0.353		NaN											0	0	0	0.008291	0	11	74									
DSCAM	1826	broad.mit.edu	37	21	41684108	41684108	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr21:41684108C>G	uc002yyq.1	-	9	2414	c.1962G>C	c.(1960-1962)TTG>TTC	p.L654F	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	654	Extracellular (Potential).|Ig-like C2-type 7.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TGGAAATCCTCAAGGAGCTCG	0.547		NaN											0	0	0	0.001168	0	6	133									
KRTAP10-11	386678	broad.mit.edu	37	21	46066950	46066950	+	Missense_Mutation	SNP	T	T	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr21:46066950T>C	uc002zfr.3	+	1	620	c.575T>C	c.(574-576)GTC>GCC	p.V192A	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198692	NP_941965	P60412	KR10B_HUMAN	keratin associated protein 10-11	192	25 X 5 AA repeats of C-C-X(3).|18.					keratin filament				ovary(1)	1						TGCGTGCCTGTCTGCTGCAAG	0.607		NaN											0	0	0	0.008361	0	31	399									
PLXNB2	23654	broad.mit.edu	37	22	50720031	50720031	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr22:50720031C>G	uc003bkv.3	-	21	3592	c.3486G>C	c.(3484-3486)CAG>CAC	p.Q1162H	PLXNB2_uc003bkt.1_5'UTR|PLXNB2_uc003bku.1_Missense_Mutation_p.Q147H	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	1162	Extracellular (Potential).			RQKR->AQKA: Abolishes cleavage by proprotein convertases.	regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TGTCTCGTTTCTGCCGCCGCT	0.697		NaN											0	0	0	0.007413	0	16	77									
FANCD2	2177	broad.mit.edu	37	3	10089628	10089628	+	Missense_Mutation	SNP	C	C	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:10089628C>A	uc003buw.2	+	16	1384	c.1306C>A	c.(1306-1308)CTG>ATG	p.L436M	FANCD2_uc003bux.1_Missense_Mutation_p.L436M|FANCD2_uc003buy.1_Missense_Mutation_p.L436M|FANCD2_uc010hcw.1_5'Flank	NM_033084	NP_149075	Q9BXW9	FACD2_HUMAN	Fanconi anemia complementation group D2 isoform	436					DNA repair|response to gamma radiation	nucleoplasm	protein binding|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.148)		TTCATCCATTCTGTCGCTGGC	0.393		NaN	D|Mis|N|F			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				1	0	5.45024e-15	0.00333	5.99715e-15	26	255									
ATP2B2	491	broad.mit.edu	37	3	10442706	10442706	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:10442706C>T	uc003bvt.2	-	5	1151	c.712G>A	c.(712-714)GAA>AAA	p.E238K	ATP2B2_uc003bvv.2_Missense_Mutation_p.E238K|ATP2B2_uc003bvw.2_Missense_Mutation_p.E238K|ATP2B2_uc010hdp.2_Missense_Mutation_p.E238K|ATP2B2_uc010hdo.2_5'UTR	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	238	Cytoplasmic (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						AGGGAGCTTTCATCAATCTTG	0.592		NaN											0	0	0	0.004007	0	17	84									
PPARG	5468	broad.mit.edu	37	3	12447544	12447544	+	Silent	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:12447544G>C	uc003bwx.2	+	5	874	c.783G>C	c.(781-783)GCG>GCC	p.A261A	PPARG_uc003bwr.2_Silent_p.A233A|PPARG_uc003bws.2_Silent_p.A233A|PPARG_uc003bwu.2_Silent_p.A233A|PPARG_uc003bwv.2_Silent_p.A233A|PPARG_uc010hea.1_RNA|PPARG_uc003bwq.1_Silent_p.A233A|PPARG_uc003bwt.1_Silent_p.A233A|PPARG_uc003bww.1_Silent_p.A261A	NM_015869	NP_056953	P37231	PPARG_HUMAN	peroxisome proliferative activated receptor	261	Interaction with FAM120B (By similarity).				activation of caspase activity|cell fate commitment|cell maturation|cellular response to insulin stimulus|epithelial cell differentiation|glucose homeostasis|induction of apoptosis|innate immune response|lipid homeostasis|lipoprotein transport|long-chain fatty acid transport|low-density lipoprotein particle receptor biosynthetic process|monocyte differentiation|negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of macrophage derived foam cell differentiation|negative regulation of receptor biosynthetic process|negative regulation of sequestering of triglyceride|negative regulation of transcription from RNA polymerase II promoter|placenta development|positive regulation of fat cell differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to lipid|response to low-density lipoprotein particle stimulus|white fat cell differentiation	cytosol|nucleoplasm	activating transcription factor binding|arachidonic acid binding|drug binding|enzyme binding|prostaglandin receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|kidney(1)	2					Atorvastatin(DB01076)|Icosapent(DB00159)|Pioglitazone(DB01132)|Rosiglitazone(DB00412)|Troglitazone(DB00197)	AAGCAAAGGCGAGGGCGATCT	0.478		NaN	T	PAX8	follicular thyroid		Insulin resistance ; lipodystrophy|familial partial L;diabetes mellitus|insulin-resistantI|with acanthosis nigricans and hypertension						0	0	0	0.004482	0	9	53									
CAND2	23066	broad.mit.edu	37	3	12861592	12861592	+	Silent	SNP	A	A	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:12861592A>G	uc003bxk.2	+	11	3001	c.2952A>G	c.(2950-2952)CCA>CCG	p.P984P	CAND2_uc003bxj.2_Silent_p.P891P	NM_001162499	NP_001155971	O75155	CAND2_HUMAN	TBP-interacting protein isoform 1	984	HEAT 21.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			skin(3)|pancreas(1)	4						CAGGTCGGCCACACACCCGGA	0.597		NaN											0	0	0	0.001855	0	14	106									
C3orf35	339883	broad.mit.edu	37	3	37476522	37476522	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:37476522C>T	uc003cha.3	+	6	1078	c.414C>T	c.(412-414)GCC>GCT	p.A138A		NM_178339	NP_848029	Q8IVJ8	APRG1_HUMAN	AP20 region protein isoform B	138						integral to membrane				central_nervous_system(1)	1						GTGGGGATGCCTGGAAAACAA	0.473		NaN											0	0	0	0.009096	0	4	49									
XIRP1	165904	broad.mit.edu	37	3	39230134	39230134	+	Missense_Mutation	SNP	G	G	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:39230134G>T	uc003cjk.1	-	2	1024	c.803C>A	c.(802-804)TCT>TAT	p.S268Y	XIRP1_uc003cji.2_Missense_Mutation_p.S268Y|XIRP1_uc003cjj.2_Intron	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	268	Xin 6.						actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		CCAGCGGGCAGACCTCACCGC	0.662		NaN											1	0	1.22574e-08	0.014323	1.3213e-08	23	91									
CTNNB1	1499	broad.mit.edu	37	3	41278172	41278172	+	Missense_Mutation	SNP	T	T	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:41278172T>A	uc010hia.1	+	14	2204	c.2048T>A	c.(2047-2049)TTC>TAC	p.F683Y	CTNNB1_uc003ckp.2_Missense_Mutation_p.F683Y|CTNNB1_uc003ckq.2_Missense_Mutation_p.F683Y|CTNNB1_uc003ckr.2_Missense_Mutation_p.F683Y|CTNNB1_uc011azf.1_Missense_Mutation_p.F676Y|CTNNB1_uc011azg.1_Missense_Mutation_p.F611Y|CTNNB1_uc003cks.2_3'UTR|CTNNB1_uc003ckt.1_3'UTR	NM_001904	NP_001895	P35222	CTNB1_HUMAN	beta-catenin	683					adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding		CTNNB1/PLAG1(60)	liver(806)|soft_tissue(609)|large_intestine(243)|endometrium(222)|kidney(172)|stomach(157)|central_nervous_system(139)|ovary(104)|skin(97)|pancreas(91)|adrenal_gland(85)|pituitary(81)|salivary_gland(62)|haematopoietic_and_lymphoid_tissue(57)|thyroid(55)|biliary_tract(41)|lung(38)|prostate(24)|bone(20)|small_intestine(17)|cervix(9)|parathyroid(9)|urinary_tract(8)|breast(7)|oesophagus(5)|NS(3)|pleura(2)|upper_aerodigestive_tract(2)|eye(1)	3166				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)	AGCTCTCTCTTCAGAACAGAG	0.458		15	H|Mis|T	PLAG1	colorectal|cvarian| hepatoblastoma|others|pleomorphic salivary adenoma				Pilomatrixoma_Familial_Clustering_of				0	0	0	0.010729	0	11	158									
CCR5	1234	broad.mit.edu	37	3	46414768	46414768	+	Silent	SNP	T	T	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:46414768T>C	uc003cpo.3	+	3	497	c.375T>C	c.(373-375)GAT>GAC	p.D125D	CCR5_uc010hjd.2_Silent_p.D125D	NM_001100168	NP_001093638	P51681	CCR5_HUMAN	chemokine (C-C motif) receptor 5	125	Cytoplasmic (Potential).				cell-cell signaling|cellular defense response|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|entry into host cell|immune response|inflammatory response|initiation of viral infection	endosome|external side of plasma membrane|integral to plasma membrane	actin binding|C-C chemokine receptor activity|coreceptor activity|phosphatidylinositol phospholipase C activity			lung(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6				BRCA - Breast invasive adenocarcinoma(193;0.00112)|KIRC - Kidney renal clear cell carcinoma(197;0.017)|Kidney(197;0.02)	Maraviroc(DB04835)	TGACAATCGATAGGTACCTGG	0.478		NaN											0	0	0	0.006214	0	10	209									
KLHDC8B	200942	broad.mit.edu	37	3	49211748	49211748	+	Silent	SNP	T	T	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:49211748T>C	uc003cwh.2	+	3	638	c.453T>C	c.(451-453)CGT>CGC	p.R151R	KLHDC8B_uc003cwi.1_Silent_p.R24R	NM_173546	NP_775817	Q8IXV7	KLD8B_HUMAN	kelch domain containing 8B	151	Kelch 4.					cytoplasm					0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00217)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		ATGAGCCCCGTCGGGACTGCT	0.597		NaN											0	0	0	0.006214	0	10	117									
AMIGO3	386724	broad.mit.edu	37	3	49756220	49756220	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:49756220G>A	uc003cxj.2	-	1	1019	c.679C>T	c.(679-681)CTC>TTC	p.L227F	RNF123_uc003cxh.2_Intron|RNF123_uc003cxi.2_Intron	NM_198722	NP_942015	Q86WK7	AMGO3_HUMAN	adhesion molecule with Ig-like domain 3	227	Extracellular (Potential).|LRRCT.				heterophilic cell-cell adhesion	integral to membrane				pancreas(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		AGGTGGTAGAGGCGGCAGTCG	0.657		NaN											0	0	0	0.00308	0	8	86									
MAGI1	9223	broad.mit.edu	37	3	65365145	65365145	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:65365145C>T	uc003dmn.2	-	17	3312	c.2786G>A	c.(2785-2787)CGC>CAC	p.R929H	MAGI1_uc003dmm.2_Missense_Mutation_p.R957H|MAGI1_uc003dmo.2_Missense_Mutation_p.R957H|MAGI1_uc003dmp.2_Missense_Mutation_p.R929H|MAGI1_uc003dmq.1_RNA|MAGI1_uc010hnx.1_Missense_Mutation_p.R240H	NM_001033057	NP_001028229	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ	957					cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			lung(2)|skin(1)|breast(1)|kidney(1)|pancreas(1)	6		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		CTGCGGAGTGCGCTTCTCTTC	0.453		NaN											0	0	0	0.00499	0	16	121									
ROBO2	6092	broad.mit.edu	37	3	77600062	77600062	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:77600062G>A	uc003dpy.3	+	8	1796	c.1153G>A	c.(1153-1155)GAC>AAC	p.D385N	ROBO2_uc003dpz.2_Missense_Mutation_p.D389N|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.D389N	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	385	Ig-like C2-type 4.|Extracellular (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		TCAACGTTCCGACGCGGGTTA	0.473		NaN											0	0	0	0.001984	0	7	74									
CCDC80	151887	broad.mit.edu	37	3	112358447	112358447	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:112358447C>T	uc003dzf.2	-	2	524	c.306G>A	c.(304-306)GTG>GTA	p.V102V	CCDC80_uc011bhv.1_Silent_p.V102V|CCDC80_uc003dzg.2_Silent_p.V102V|CCDC80_uc003dzh.1_Silent_p.V102V	NM_199512	NP_955806	Q76M96	CCD80_HUMAN	steroid-sensitive protein 1 precursor	102										ovary(2)	2						GCTCAGGTCTCACGGCGGCCC	0.607		NaN											0	0	0	0.005443	0	25	135									
PRR23B	389151	broad.mit.edu	37	3	138738765	138738765	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:138738765G>A	uc003esy.1	-	1	1004	c.739C>T	c.(739-741)CGC>TGC	p.R247C		NM_001013650	NP_001013672	Q6ZRT6	PR23B_HUMAN	proline rich 23B	247	Pro-rich.									breast(1)	1						AGCGGCGAGCGCGCGTGGGGA	0.657		NaN											0	0	0	0.010729	0	12	84									
LRRIQ4	344657	broad.mit.edu	37	3	169540297	169540297	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:169540297C>T	uc003fgb.2	+	1	588	c.588C>T	c.(586-588)GAC>GAT	p.D196D		NM_001080460	NP_001073929	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	196	LRR 8.										0						TTGACCTGGACGAGAACAAAA	0.517		NaN											0	0	0	0.010729	0	12	142									
C3orf43	255798	broad.mit.edu	37	3	196234952	196234952	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:196234952C>T	uc003fws.2	-	3	608	c.451G>A	c.(451-453)GAA>AAA	p.E151K	C3orf43_uc003fwr.2_Missense_Mutation_p.E143K	NM_001077657	NP_001071125	Q147U7	CC043_HUMAN	hypothetical protein LOC255798	151						integral to membrane				ovary(1)	1	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;2.13e-23)|all cancers(36;2e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00298)		GTATAGTGTTCTGCCTTGTTA	0.463		NaN											0	0	0	0.013537	0	13	105									
FGFRL1	53834	broad.mit.edu	37	4	1019074	1019074	+	Missense_Mutation	SNP	A	A	T	rs77570255		TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr4:1019074A>T	uc003gce.2	+	7	1615	c.1454A>T	c.(1453-1455)CAC>CTC	p.H485L	FGFRL1_uc003gcf.2_Missense_Mutation_p.H485L|FGFRL1_uc003gcg.2_Missense_Mutation_p.H485L|FGFRL1_uc010ibo.2_Missense_Mutation_p.H485L	NM_021923	NP_068742	Q8N441	FGRL1_HUMAN	fibroblast growth factor receptor-like 1	485	His-rich.|Cytoplasmic (Potential).				regulation of cell growth	integral to membrane|plasma membrane	fibroblast growth factor receptor activity|heparin binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			acacacacacactctcacaca	0.483		NaN											0	0	0	0.004672	0	3	16									
KLB	152831	broad.mit.edu	37	4	39448824	39448824	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr4:39448824C>T	uc003gua.2	+	4	2575	c.2478C>T	c.(2476-2478)TTC>TTT	p.F826F	KLB_uc011byj.1_Silent_p.F817F	NM_175737	NP_783864	Q86Z14	KLOTB_HUMAN	klotho beta	826	Extracellular (Potential).|Glycosyl hydrolase-1 2.				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			skin(1)	1						TCAACCACTTCACCACTAGGT	0.657		NaN											0	0	0	0.010504	0	21	90									
LRRC66	339977	broad.mit.edu	37	4	52861415	52861415	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr4:52861415C>T	uc003gzi.2	-	4	1786	c.1773G>A	c.(1771-1773)ATG>ATA	p.M591I		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	591						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						CATGTGTTAGCATTTTACAGA	0.483		NaN											0	0	0	0.013537	0	13	172									
LRRC66	339977	broad.mit.edu	37	4	52861829	52861829	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr4:52861829C>T	uc003gzi.2	-	4	1372	c.1359G>A	c.(1357-1359)GAG>GAA	p.E453E		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	453						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						GGGTCTGGTTCTCGTAGAGGC	0.542		NaN											0	0	0	0.008291	0	11	115									
IGJ	3512	broad.mit.edu	37	4	71527924	71527924	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr4:71527924C>T	uc003hfn.3	-	2	214	c.73G>A	c.(73-75)GAT>AAT	p.D25N	IGJ_uc010ihz.2_Missense_Mutation_p.D41N	NM_144646	NP_653247	P01591	IGJ_HUMAN	immunoglobulin J chain	25					immune response	extracellular region	antigen binding				0			Lung(101;0.235)			ATCCTTTCATCTTCTTGGGCT	0.358		NaN											0	0	0	0.008291	0	11	68									
SMARCAD1	56916	broad.mit.edu	37	4	95170811	95170811	+	Nonsense_Mutation	SNP	G	G	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr4:95170811G>T	uc003htc.3	+	7	967	c.712G>T	c.(712-714)GAA>TAA	p.E238*	SMARCAD1_uc003htb.3_Nonsense_Mutation_p.E238*|SMARCAD1_uc003htd.3_Nonsense_Mutation_p.E238*|SMARCAD1_uc010ila.2_Nonsense_Mutation_p.E101*	NM_020159	NP_064544	Q9H4L7	SMRCD_HUMAN	SWI/SNF-related, matrix-associated	238					chromatin modification|nucleotide metabolic process|positive regulation of transcription, DNA-dependent|protein homooligomerization|regulation of DNA recombination	nuclear matrix	ATP binding|DNA binding|helicase activity			skin(2)|ovary(1)|breast(1)	4				OV - Ovarian serous cystadenocarcinoma(123;4.33e-08)		TTAGGGAGAGGAATCAAATGA	0.323		NaN											1	0	1.06961e-07	0.00308	1.1414e-07	8	44									
BANK1	55024	broad.mit.edu	37	4	102946423	102946423	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr4:102946423G>C	uc003hvy.3	+	9	1625	c.1351G>C	c.(1351-1353)GAG>CAG	p.E451Q	BANK1_uc003hvx.3_Missense_Mutation_p.E436Q|BANK1_uc010ill.2_Missense_Mutation_p.E318Q|BANK1_uc003hvz.3_Missense_Mutation_p.E421Q	NM_017935	NP_060405	Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	451					B cell activation					ovary(2)|skin(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		AGATGGAGCTGAGGCAAATGA	0.453		NaN											0	0	0	0.001855	0	14	118									
FAT4	79633	broad.mit.edu	37	4	126240575	126240575	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr4:126240575C>T	uc003ifj.3	+	1	3009	c.3009C>T	c.(3007-3009)GTC>GTT	p.V1003V		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1003	Cadherin 10.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CTTATGAAGTCACCCTTTCTG	0.408		NaN											0	0	0	0.004482	0	7	93									
FAT4	79633	broad.mit.edu	37	4	126411502	126411502	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr4:126411502G>A	uc003ifj.3	+	17	13525	c.13525G>A	c.(13525-13527)GTG>ATG	p.V4509M	FAT4_uc011cgp.1_Missense_Mutation_p.V2750M|FAT4_uc003ifi.1_Missense_Mutation_p.V1986M	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4509	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GCCTGCCATCGTGGGCAGCTG	0.577		NaN											0	0	0	0.006214	0	10	111									
LRBA	987	broad.mit.edu	37	4	151771906	151771906	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr4:151771906G>A	uc010ipj.2	-	24	4448	c.3974C>T	c.(3973-3975)TCA>TTA	p.S1325L	LRBA_uc003ilt.3_5'Flank|LRBA_uc003ilu.3_Missense_Mutation_p.S1325L	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	1325	WD 1.					endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					TGTTTCTATTGAAAATAATAG	0.343		NaN											0	0	0	0.000602	0	5	23									
FBXW7	55294	broad.mit.edu	37	4	153244185	153244185	+	Nonsense_Mutation	SNP	G	G	A	rs144247898		TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr4:153244185G>A	uc003ims.2	-	12	2121	c.1972C>T	c.(1972-1974)CGA>TGA	p.R658*	FBXW7_uc011cii.1_Nonsense_Mutation_p.R658*|FBXW7_uc003imt.2_Nonsense_Mutation_p.R658*|FBXW7_uc011cih.1_Nonsense_Mutation_p.R482*|FBXW7_uc003imq.2_Nonsense_Mutation_p.R578*|FBXW7_uc003imr.2_Nonsense_Mutation_p.R540*	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	658	WD 7.				interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding	p.R658*(1)		haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				ACTAGGTTTCGAATAAATTCA	0.473		NaN	Mis|N|D|F		colorectal|endometrial|T-ALL								0	0	0	0.004482	0	8	121									
FBXW7	55294	broad.mit.edu	37	4	153247165	153247165	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr4:153247165G>A	uc003ims.2	-	10	1786	c.1637C>T	c.(1636-1638)TCA>TTA	p.S546L	FBXW7_uc011cii.1_Missense_Mutation_p.S546L|FBXW7_uc003imt.2_Missense_Mutation_p.S546L|FBXW7_uc011cih.1_Missense_Mutation_p.S370L|FBXW7_uc003imq.2_Missense_Mutation_p.S466L|FBXW7_uc003imr.2_Missense_Mutation_p.S428L	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	546	WD 5.				interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding			haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TACCTGTAATGAATAGACTCT	0.398		NaN	Mis|N|D|F		colorectal|endometrial|T-ALL								0	0	0	0.001855	0	13	86									
RNASEN	29102	broad.mit.edu	37	5	31521263	31521263	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr5:31521263C>G	uc003jhg.2	-	5	1273	c.914G>C	c.(913-915)AGG>ACG	p.R305T	RNASEN_uc003jhh.2_Missense_Mutation_p.R305T|RNASEN_uc003jhi.2_Missense_Mutation_p.R305T|RNASEN_uc010iui.1_Intron	NM_013235	NP_037367	Q9NRR4	RNC_HUMAN	ribonuclease III, nuclear isoform 1	305	Arg-rich.				gene silencing by RNA|ribosome biogenesis|RNA processing	nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity				0						TTTGTAGGACCTTTCCAGAGA	0.408		NaN											0	0	0	0.001855	0	12	154									
GOLPH3	64083	broad.mit.edu	37	5	32143969	32143969	+	Missense_Mutation	SNP	C	C	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr5:32143969C>A	uc003jhp.1	-	2	528	c.243G>T	c.(241-243)TGG>TGT	p.W81C		NM_022130	NP_071413	Q9H4A6	GOLP3_HUMAN	golgi phosphoprotein 3	81					cell proliferation|positive regulation of TOR signaling cascade|regulation of mitochondrion organization	cytosol|endosome|Golgi cisterna membrane|mitochondrial intermembrane space|plasma membrane|trans-Golgi network	protein binding			ovary(1)	1						TACAGTCATTCCAAAATGATG	0.318		NaN											1	0	1.06961e-07	0.00308	1.1414e-07	8	68									
WDR70	55100	broad.mit.edu	37	5	37727078	37727078	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr5:37727078G>A	uc003jkv.2	+	17	1866	c.1808G>A	c.(1807-1809)CGG>CAG	p.R603Q		NM_018034	NP_060504	Q9NW82	WDR70_HUMAN	WD repeat domain 70	603										ovary(1)|central_nervous_system(1)	2	all_lung(31;0.000285)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AGTAATCCTCGGGAAGCCATT	0.463		NaN											0	0	0	0.00308	0	8	91									
IQGAP2	10788	broad.mit.edu	37	5	75902129	75902129	+	Splice_Site	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr5:75902129G>A	uc003kek.2	+	12	1579	c.1357_splice	c.e12+1	p.R453_splice	IQGAP2_uc010izv.2_5'Flank|IQGAP2_uc011csv.1_5'Flank|IQGAP2_uc003kel.2_5'Flank	NM_006633	NP_006624	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2						small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			ovary(6)|central_nervous_system(1)	7		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		GAAAATGACCGTAAGTATAAG	0.348		NaN											0	0	0	0.004672	0	3	35									
PPIP5K2	23262	broad.mit.edu	37	5	102518935	102518935	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr5:102518935G>A	uc003kod.3	+	25	3442	c.2923G>A	c.(2923-2925)GAA>AAA	p.E975K	PPIP5K2_uc011cva.1_RNA|PPIP5K2_uc003koe.2_Missense_Mutation_p.E975K|PPIP5K2_uc003kof.2_Intron	NM_015216	NP_056031	O43314	VIP2_HUMAN	Histidine acid phosphatase domain containing 1	975					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			ovary(1)|skin(1)	2						TCACTTCCAGGAAGAGAGCCC	0.443		NaN											0	0	0	0.001168	0	6	36									
SHROOM1	134549	broad.mit.edu	37	5	132160002	132160002	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr5:132160002C>G	uc003kxx.2	-	7	2156	c.1351G>C	c.(1351-1353)GAT>CAT	p.D451H	SHROOM1_uc003kxy.1_Missense_Mutation_p.D451H	NM_133456	NP_597713	Q2M3G4	SHRM1_HUMAN	shroom family member 1	451					actin filament bundle assembly|cell morphogenesis	cytoplasm|microtubule	actin filament binding			pancreas(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CAGCAGTCATCTGCCCCTGCA	0.557		NaN											0	0	0	0.001168	0	6	38									
PCDHA1	56147	broad.mit.edu	37	5	140167320	140167320	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr5:140167320C>T	uc003lhb.2	+	1	1445	c.1445C>T	c.(1444-1446)GCG>GTG	p.A482V	PCDHA1_uc003lha.2_Missense_Mutation_p.A482V|PCDHA1_uc003lgz.2_Missense_Mutation_p.A482V	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	482	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCGGGACGCGGACGCGCAG	0.657		NaN											0	0	0	0.010729	0	9	173									
PCDHA9	9752	broad.mit.edu	37	5	140230132	140230132	+	Silent	SNP	G	G	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr5:140230132G>T	uc003lhu.2	+	1	2776	c.2052G>T	c.(2050-2052)GTG>GTT	p.V684V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Silent_p.V684V	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	684	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGCGTCAGTGGGTGCCACGG	0.652		NaN											1	0	3.28513e-13	0.003954	3.60231e-13	26	117									
ARAP3	64411	broad.mit.edu	37	5	141050834	141050834	+	Nonsense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr5:141050834G>C	uc003llm.2	-	13	2066	c.1988C>G	c.(1987-1989)TCA>TGA	p.S663*	ARAP3_uc011dbe.1_Nonsense_Mutation_p.S325*|ARAP3_uc003lln.2_Intron	NM_022481	NP_071926	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	663					cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			breast(5)|ovary(1)|large_intestine(1)	7						GGAATGACCTGAGGGCAAGAG	0.572		NaN											0	0	0	0.004007	0	13	71									
LARS	51520	broad.mit.edu	37	5	145512562	145512562	+	Silent	SNP	G	G	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr5:145512562G>T	uc003lnx.1	-	23	2533	c.2295C>A	c.(2293-2295)CTC>CTA	p.L765L	LARS_uc003lnw.1_5'Flank|LARS_uc011dbq.1_Silent_p.L719L|LARS_uc011dbr.1_Silent_p.L711L|LARS_uc011dbs.1_Silent_p.L738L	NM_020117	NP_064502	Q9P2J5	SYLC_HUMAN	leucyl-tRNA synthetase	765					leucyl-tRNA aminoacylation	cytosol	ATP binding|leucine-tRNA ligase activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Leucine(DB00149)	TGTACAGACGGAGAATACCTG	0.478		NaN											1	0	2.0095e-06	0.001984	2.12299e-06	7	56									
GABRB2	2561	broad.mit.edu	37	5	160757993	160757993	+	Missense_Mutation	SNP	A	A	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr5:160757993A>G	uc003lys.1	-	9	1192	c.974T>C	c.(973-975)CTA>CCA	p.L325P	GABRB2_uc011deh.1_Missense_Mutation_p.L164P|GABRB2_uc003lyr.1_Missense_Mutation_p.L325P|GABRB2_uc003lyt.1_Missense_Mutation_p.L325P|GABRB2_uc010jiu.1_Missense_Mutation_p.L262P	NM_021911	NP_068711	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	325	Helical; (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity				0	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	GTAGTTGACTAGGGCATATTC	0.512		NaN											0	0	0	0.008871	0	21	93									
ODZ2	57451	broad.mit.edu	37	5	167645734	167645734	+	Missense_Mutation	SNP	A	A	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr5:167645734A>G	uc010jjd.2	+	23	4811	c.4811A>G	c.(4810-4812)TAC>TGC	p.Y1604C	ODZ2_uc003lzr.3_Missense_Mutation_p.Y1374C|ODZ2_uc003lzt.3_Missense_Mutation_p.Y977C|ODZ2_uc010jje.2_Missense_Mutation_p.Y868C	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		ACAGGGGAGTACTTGTACAAT	0.473		NaN											0	0	0	0.010729	0	12	124									
FOXQ1	94234	broad.mit.edu	37	6	1313431	1313431	+	Silent	SNP	C	C	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:1313431C>A	uc003mtl.3	+	1	757	c.492C>A	c.(490-492)CGC>CGA	p.R164R		NM_033260	NP_150285	Q9C009	FOXQ1_HUMAN	forkhead box Q1	164	Fork-head.				DNA fragmentation involved in apoptotic nuclear change|embryo development|hair follicle morphogenesis|pattern specification process|positive regulation of caspase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	caspase regulator activity|DNA bending activity|double-stranded DNA binding|estrogen receptor binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin conjugating enzyme binding				0	Ovarian(93;0.0733)	Breast(5;0.052)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.0954)|BRCA - Breast invasive adenocarcinoma(62;0.18)		CGGGCTGGCGCAACTCCGTGC	0.647		NaN											1	0	0.000442599	0.006214	0.000456969	9	92									
CDYL	9425	broad.mit.edu	37	6	4892403	4892403	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:4892403G>A	uc003mwi.2	+	4	774	c.643G>A	c.(643-645)GAG>AAG	p.E215K	CDYL_uc003mwj.2_Missense_Mutation_p.E161K|CDYL_uc003mwk.2_Intron|CDYL_uc011dhx.1_Missense_Mutation_p.E29K|CDYL_uc011dhy.1_Missense_Mutation_p.E29K	NM_001143971	NP_001137443	Q9Y232	CDYL1_HUMAN	chromodomain protein, Y chromosome-like isoform	215					regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	histone acetyltransferase activity				0	Ovarian(93;0.11)	all_hematologic(90;0.0901)|Lung NSC(90;0.244)		OV - Ovarian serous cystadenocarcinoma(45;0.182)		CTTTCAGAGCGAGAGCCCTGA	0.602		NaN											0	0	0	0.000602	0	5	70									
MUTED	63915	broad.mit.edu	37	6	8041460	8041460	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:8041460C>T	uc003mxy.2	-	3	275	c.237G>A	c.(235-237)TTG>TTA	p.L79L	TXNDC5_uc003mxw.2_5'UTR|MUTED_uc010joc.2_Silent_p.L15L|MUTED_uc010job.2_RNA	NM_201280	NP_958437	Q8TDH9	MUTED_HUMAN	muted	79						BLOC-1 complex	protein binding				0	Ovarian(93;0.0398)					TCATGTTCTTCAAATTTTCAA	0.353		NaN											0	0	0	0.006214	0	10	58									
SCAND3	114821	broad.mit.edu	37	6	28547168	28547168	+	Missense_Mutation	SNP	A	A	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:28547168A>T	uc003nlo.2	-	2	1067	c.449T>A	c.(448-450)GTT>GAT	p.V150D		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	150					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TTCCATAGAAACTTCCTGCCC	0.413		NaN											0	0	0	0.001855	0	12	93									
C6orf15	29113	broad.mit.edu	37	6	31079947	31079947	+	Silent	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:31079947G>A	uc003nsk.1	-	2	189	c.189C>T	c.(187-189)CCC>CCT	p.P63P	PSORS1C1_uc003nsl.1_5'Flank|PSORS1C1_uc010jsj.1_5'Flank	NM_014070	NP_054789	Q6UXA7	CF015_HUMAN	STG protein precursor	63											0						GGTCCAGAGCGGGCTGCGGAT	0.562		NaN											0	0	0	0.00499	0	18	141									
LY6G5B	58496	broad.mit.edu	37	6	31639913	31639913	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:31639913G>C	uc003nvt.1	+	3	460	c.460G>C	c.(460-462)GAG>CAG	p.E154Q	CSNK2B_uc003nvs.1_3'UTR	NM_021221	NP_067044	Q8NDX9	LY65B_HUMAN	lymphocyte antigen 6 complex G5B precursor	154						extracellular region					0						TGCTGGGACGGAGCCTGATGG	0.587		NaN											0	0	0	0.008291	0	10	74									
RPS18	6222	broad.mit.edu	37	6	33243657	33243657	+	Silent	SNP	T	T	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:33243657T>C	uc003odp.1	+	3	231	c.186T>C	c.(184-186)GAT>GAC	p.D62D	RPS18_uc010jum.1_RNA|RPS18_uc003odq.1_RNA|B3GALT4_uc003odr.2_5'Flank	NM_022551	NP_072045	P62269	RS18_HUMAN	ribosomal protein S18	62					endocrine pancreas development|ribosome biogenesis|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	rRNA binding|structural constituent of ribosome				0						TCACTGAGGATGAGGTGAGGA	0.567		NaN											0	0	0	0.001168	0	6	136									
TCP11	6954	broad.mit.edu	37	6	35088699	35088699	+	Silent	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:35088699G>C	uc003okd.2	-	6	922	c.741C>G	c.(739-741)CTC>CTG	p.L247L	TCP11_uc003ojz.1_Silent_p.L172L|TCP11_uc003oka.2_Silent_p.L172L|TCP11_uc003okb.2_Silent_p.L171L|TCP11_uc003okc.2_Silent_p.L171L|TCP11_uc011dsu.1_Silent_p.L229L|TCP11_uc011dsv.1_Silent_p.L196L|TCP11_uc011dsw.1_Silent_p.L201L	NM_001093728	NP_001087197	Q8WWU5	TCP11_HUMAN	t-complex 11 isoform 1	234					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(3)|skin(2)	5						GCTGCTTATTGAGGAGTTCCT	0.423		NaN											0	0	0	0.01441	0	69	392									
PPARD	5467	broad.mit.edu	37	6	35387983	35387983	+	Silent	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:35387983C>G	uc003okm.2	+	4	519	c.210C>G	c.(208-210)CTC>CTG	p.L70L	PPARD_uc003okl.2_Silent_p.L70L|PPARD_uc003okn.2_Silent_p.L70L|PPARD_uc011dtb.1_Silent_p.L31L|PPARD_uc011dtc.1_Intron|PPARD_uc010jvv.1_Intron	NM_006238	NP_006229	Q03181	PPARD_HUMAN	peroxisome proliferative activated receptor,	70					apoptosis|axon ensheathment|cholesterol metabolic process|decidualization|embryo implantation|fatty acid beta-oxidation|fatty acid transport|generation of precursor metabolites and energy|glucose metabolic process|glucose transport|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fat cell differentiation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	drug binding|linoleic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1					Icosapent(DB00159)|Sulindac(DB00605)|Treprostinil(DB00374)	GCGGCAGCCTCAACATGGAGT	0.652		NaN											0	0	0	0.013537	0	12	71									
TFAP2D	83741	broad.mit.edu	37	6	50696937	50696937	+	Silent	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:50696937G>C	uc003paf.2	+	5	1307	c.795G>C	c.(793-795)CTG>CTC	p.L265L	TFAP2D_uc011dwt.1_RNA	NM_172238	NP_758438	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 beta-like 1	265							DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|breast(1)	7	Lung NSC(77;0.0334)					GCCGCTGCCTGAGAGAGAAAT	0.408		NaN											0	0	0	0.013537	0	13	124									
GRIK2	2898	broad.mit.edu	37	6	102337572	102337572	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:102337572G>A	uc003pqp.3	+	11	1831	c.1582G>A	c.(1582-1584)GAC>AAC	p.D528N	GRIK2_uc003pqn.2_Missense_Mutation_p.D528N|GRIK2_uc003pqo.3_Missense_Mutation_p.D528N|GRIK2_uc010kcw.2_Missense_Mutation_p.D528N	NM_021956	NP_068775	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	528	Extracellular (Potential).				glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|pancreas(1)|breast(1)|skin(1)	5		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	GAAGGTCATCGACTTTTCCAA	0.408		NaN											0	0	0	0.00245	0	14	124									
FAM184A	79632	broad.mit.edu	37	6	119300685	119300685	+	Splice_Site	SNP	T	T	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:119300685T>C	uc003pyj.2	-	11	2650	c.2302_splice	c.e11-1	p.A768_splice	FAM184A_uc003pyk.3_Splice_Site_p.A648_splice|FAM184A_uc003pyl.3_Splice_Site_p.A648_splice	NM_024581	NP_078857	Q8NB25	F184A_HUMAN	hypothetical protein LOC79632 isoform 1											ovary(2)|central_nervous_system(2)|skin(2)|pancreas(1)	7						TTCAAGAGCCTAGAACAAGAC	0.328		NaN											0	0	0	0.009096	0	4	31									
TAAR8	83551	broad.mit.edu	37	6	132874511	132874511	+	Missense_Mutation	SNP	C	C	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:132874511C>A	uc011ecj.1	+	1	680	c.680C>A	c.(679-681)GCT>GAT	p.A227D		NM_053278	NP_444508	Q969N4	TAAR8_HUMAN	trace amine associated receptor 8	227	Cytoplasmic (Potential).					plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.00412)|GBM - Glioblastoma multiforme(226;0.00792)		AAACAACAAGCTATAAAAATT	0.358		NaN											1	0	3.86212e-05	0.008291	4.01358e-05	11	77									
TMEM181	57583	broad.mit.edu	37	6	159046150	159046150	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:159046150C>T	uc003qrm.3	+	12	1391	c.1380C>T	c.(1378-1380)TTC>TTT	p.F460F	TMEM181_uc010kjr.1_Silent_p.F291F	NM_020823	NP_065874	Q9P2C4	TM181_HUMAN	G protein-coupled receptor 178	460	Helical; (Potential).				pathogenesis	integral to membrane	toxin binding			ovary(2)|central_nervous_system(1)	3		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;8.15e-18)|BRCA - Breast invasive adenocarcinoma(81;1.38e-05)		TGAAGGTCTTCTTCATGGTGG	0.547		NaN											0	0	0	0.00308	0	8	153									
C7orf50	84310	broad.mit.edu	37	7	1037332	1037332	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr7:1037332C>T	uc003sju.2	-	5	584	c.514G>A	c.(514-516)GAG>AAG	p.E172K	C7orf50_uc003sjs.2_RNA|C7orf50_uc011jvt.1_Missense_Mutation_p.E172K|C7orf50_uc011jvu.1_Missense_Mutation_p.E172K	NM_032350	NP_115726	Q9BRJ6	CG050_HUMAN	hypothetical protein LOC84310	172							protein binding				0		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0216)|OV - Ovarian serous cystadenocarcinoma(56;1.3e-15)		GAGCCCTCCTCATCCAGCTCC	0.711		NaN											0	0	0	0.004482	0	8	80									
FTSJ2	29960	broad.mit.edu	37	7	2274900	2274900	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr7:2274900G>C	uc003slm.2	-	3	627	c.598C>G	c.(598-600)CAA>GAA	p.Q200E	MAD1L1_uc003slh.1_5'Flank|MAD1L1_uc003slf.1_5'Flank|MAD1L1_uc003slg.1_5'Flank|MAD1L1_uc010ksh.1_5'Flank|MAD1L1_uc003sli.1_5'Flank|MAD1L1_uc010ksi.1_5'Flank|MAD1L1_uc010ksj.2_5'Flank|FTSJ2_uc003slk.2_Missense_Mutation_p.Q46E|FTSJ2_uc003sll.2_Missense_Mutation_p.Q46E|FTSJ2_uc003sln.2_RNA|FTSJ2_uc003slo.2_Missense_Mutation_p.Q46E	NM_013393	NP_037525	Q9UI43	RRMJ2_HUMAN	FtsJ homolog 2	200					cell proliferation	mitochondrion|nucleolus	nucleic acid binding|rRNA (uridine-2'-O-)-methyltransferase activity			ovary(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0822)|OV - Ovarian serous cystadenocarcinoma(56;2.7e-14)		CGACGGCTTTGACTTCCAGCC	0.507		NaN											0	0	0	0.00245	0	15	105									
DNAH11	8701	broad.mit.edu	37	7	21920404	21920404	+	Missense_Mutation	SNP	A	A	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr7:21920404A>G	uc003svc.2	+	76	12332	c.12301A>G	c.(12301-12303)AGA>GGA	p.R4101G		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	4101	AAA 6 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TGTTGCTGGGAGACTGAGGTT	0.478		NaN							Kartagener_syndrome				0	0	0	0.008291	0	11	120									
EGFR	1956	broad.mit.edu	37	7	55259449	55259449	+	Missense_Mutation	SNP	G	G	A	rs146121458		TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr7:55259449G>A	uc003tqk.2	+	21	2753	c.2507G>A	c.(2506-2508)CGC>CAC	p.R836H	EGFR_uc010kzg.1_Missense_Mutation_p.R791H|EGFR_uc011kco.1_Missense_Mutation_p.R783H|uc003tqo.2_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	836	Cytoplasmic (Potential).|Protein kinase.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.R836C(2)|p.R836R(1)|p.R836S(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TTGGTGCACCGCGACCTGGCA	0.537		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			0	0	0	0.008291	0	10	117									
TPST1	8460	broad.mit.edu	37	7	65705842	65705842	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr7:65705842G>A	uc003tuw.2	+	2	782	c.430G>A	c.(430-432)GAA>AAA	p.E144K	TPST1_uc010kzy.2_Intron|TPST1_uc010kzz.2_Missense_Mutation_p.E144K|TPST1_uc010laa.2_Missense_Mutation_p.E144K	NM_003596	NP_003587	O60507	TPST1_HUMAN	tyrosylprotein sulfotransferase 1	144	Lumenal (Potential).				inflammatory response|peptidyl-tyrosine sulfation	Golgi membrane|integral to membrane|membrane fraction	protein-tyrosine sulfotransferase activity				0						CTTCTTACTAGAAATTATCGT	0.438		NaN											0	0	0	0.009096	0	4	86									
PCLO	27445	broad.mit.edu	37	7	82784366	82784366	+	Missense_Mutation	SNP	A	A	G	rs112239934		TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr7:82784366A>G	uc003uhx.2	-	2	1880	c.1591T>C	c.(1591-1593)TCT>CCT	p.S531P	PCLO_uc003uhv.2_Missense_Mutation_p.S531P	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	477	Gln-rich.|Pro-rich.|10 X 10 AA tandem approximate repeats of P-A-K-P-Q-P-Q-Q-P-X.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GGCTGTTGAGATGGGGGTTTT	0.557		NaN											0	0	0	0.008291	0	8	357									
PCLO	27445	broad.mit.edu	37	7	82784471	82784471	+	Missense_Mutation	SNP	A	A	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr7:82784471A>G	uc003uhx.2	-	2	1775	c.1486T>C	c.(1486-1488)TCA>CCA	p.S496P	PCLO_uc003uhv.2_Missense_Mutation_p.S496P	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GGCTTTGCTGAGCCAGGCTGT	0.607		NaN											0	0	0	0.001855	0	11	238									
AKAP9	10142	broad.mit.edu	37	7	91691704	91691704	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr7:91691704G>C	uc003ulg.2	+	24	6106	c.5881G>C	c.(5881-5883)GAA>CAA	p.E1961Q	AKAP9_uc003ulf.2_Missense_Mutation_p.E1961Q|AKAP9_uc003uli.2_Missense_Mutation_p.E1584Q	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	1973	Potential.|Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			CAGGTTGCAAGAATTGGAGGC	0.403		NaN	T	BRAF	papillary thyroid								0	0	0	0.004482	0	9	120									
GIGYF1	64599	broad.mit.edu	37	7	100281007	100281007	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr7:100281007G>C	uc003uwg.1	-	18	3122	c.2113C>G	c.(2113-2115)CGA>GGA	p.R705G		NM_022574	NP_072096	O75420	PERQ1_HUMAN	PERQ amino acid rich, with GYF domain 1	705										large_intestine(1)|central_nervous_system(1)	2	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					TTCTCCTCTCGACGCTTGCGT	0.647		NaN											0	0	0	0.004656	0	27	245									
STMN4	81551	broad.mit.edu	37	8	27099982	27099982	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr8:27099982G>A	uc003xfk.2	-	3	155	c.41C>T	c.(40-42)CCG>CTG	p.P14L	STMN4_uc003xfj.2_Missense_Mutation_p.P14L|STMN4_uc011lai.1_Missense_Mutation_p.P14L|STMN4_uc011laj.1_Missense_Mutation_p.P5L|STMN4_uc011lak.1_Missense_Mutation_p.P14L|STMN4_uc010luo.2_Missense_Mutation_p.P14L			Q9H169	STMN4_HUMAN	RecName: Full=Stathmin-4; AltName: Full=Stathmin-like protein B3;          Short=RB3;	14					intracellular signal transduction					large_intestine(1)|pancreas(1)	2		Ovarian(32;0.00167)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0214)|Epithelial(17;9.82e-10)|Colorectal(74;0.142)		GGACACCAGCGGGAGCTCCTT	0.567		NaN											0	0	0	0.004482	0	9	47									
MYST3	7994	broad.mit.edu	37	8	41790659	41790659	+	Silent	SNP	T	T	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr8:41790659T>G	uc010lxb.2	-	18	5623	c.5079A>C	c.(5077-5079)CCA>CCC	p.P1693P	MYST3_uc010lxc.2_Silent_p.P1693P|MYST3_uc003xon.3_Silent_p.P1693P	NM_001099412	NP_001092882	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic	1693	Gln/Pro-rich.				histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)			ggggagggggtgggggtggag	0.164		NaN											0	0	0	0.001855	0	5	17									
AP3M2	10947	broad.mit.edu	37	8	42023048	42023048	+	Missense_Mutation	SNP	G	G	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr8:42023048G>T	uc003xop.2	+	7	1064	c.773G>T	c.(772-774)CGC>CTC	p.R258L	AP3M2_uc003xoo.2_Missense_Mutation_p.R258L|AP3M2_uc010lxe.2_RNA|AP3M2_uc003xoq.1_Missense_Mutation_p.R143L|AP3M2_uc003xor.1_Missense_Mutation_p.R258L	NM_001134296	NP_001127768	P53677	AP3M2_HUMAN	adaptor-related protein complex 3, mu 2 subunit	258	MHD.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|Golgi apparatus					0	all_cancers(6;8.14e-25)|all_epithelial(6;2.41e-27)|all_lung(13;5.09e-13)|Lung NSC(13;8.38e-12)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|Colorectal(10;0.00165)|OV - Ovarian serous cystadenocarcinoma(14;0.00346)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)			GGAAACTTCCGCCTGCTGTCT	0.448		NaN											1	0	2.61681e-11	0.00245	2.84009e-11	14	216									
PLAG1	5324	broad.mit.edu	37	8	57079984	57079984	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr8:57079984C>T	uc003xsq.3	-	3	772	c.321G>A	c.(319-321)CTG>CTA	p.L107L	PLAG1_uc003xsr.3_Silent_p.L107L|PLAG1_uc010lyi.2_Silent_p.L107L|PLAG1_uc010lyj.2_Silent_p.L25L	NM_001114635	NP_001108107	Q6DJT9	PLAG1_HUMAN	pleiomorphic adenoma gene 1 isoform b	107	Decreased nuclear import with localization in the nucleus but also in the cytoplasm.|C2H2-type 3.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding		CTNNB1/PLAG1(60)|FGFR1_ENST00000447712/PLAG1(28)|CHCHD7/PLAG1(12)|LIFR_ENST00000263409/PLAG1(10)|HAS2/PLAG1(10)|COL1A2/PLAG1(3)|TCEA1_ENST00000521604/PLAG1(3)	salivary_gland(113)|soft_tissue(13)|lung(1)|central_nervous_system(1)|breast(1)	129		all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.125)	Epithelial(17;0.00179)|all cancers(17;0.0125)			GGTGATTCTTCAGATGATCTT	0.393		NaN	T	TCEA1|LIFR|CTNNB1|CHCHD7	salivary adenoma								0	0	0	0.009096	0	4	28									
CPA6	57094	broad.mit.edu	37	8	68334769	68334769	+	Silent	SNP	G	G	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr8:68334769G>T	uc003xxq.3	-	11	1540	c.1284C>A	c.(1282-1284)ATC>ATA	p.I428I	CPA6_uc003xxr.3_Silent_p.I184I	NM_020361	NP_065094	Q8N4T0	CBPA6_HUMAN	carboxypeptidase A6 isoform 1 precursor	428					proteolysis	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2			Epithelial(68;0.04)|OV - Ovarian serous cystadenocarcinoma(28;0.0593)|all cancers(69;0.136)			GGTGCATTGTGATATTTTTCA	0.453		NaN											1	0	4.3838e-07	0.001855	4.66237e-07	12	173									
VPS13B	157680	broad.mit.edu	37	8	100796630	100796630	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr8:100796630G>A	uc003yiv.2	+	43	8053	c.7942G>A	c.(7942-7944)GAT>AAT	p.D2648N	VPS13B_uc003yiw.2_Missense_Mutation_p.D2623N	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	2648					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TGGCCAGGTGGATACTGATGA	0.468		NaN											0	0	0	0.012319	0	22	179									
YWHAZ	7534	broad.mit.edu	37	8	101932934	101932934	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr8:101932934C>G	uc011lhe.1	-	6	902	c.725G>C	c.(724-726)GGA>GCA	p.G242A	YWHAZ_uc003yjv.2_Missense_Mutation_p.G242A|YWHAZ_uc011lhf.1_Missense_Mutation_p.G242A|YWHAZ_uc003yjw.2_Missense_Mutation_p.G242A|YWHAZ_uc010mbq.2_Missense_Mutation_p.G165A|YWHAZ_uc011lhg.1_Missense_Mutation_p.G122A|YWHAZ_uc010mbr.2_Missense_Mutation_p.G242A|YWHAZ_uc003yjx.2_Missense_Mutation_p.G242A	NM_001135702	NP_001129174	P63104	1433Z_HUMAN	tyrosine 3/tryptophan 5 -monooxygenase	242					anti-apoptosis|mRNA metabolic process|platelet activation|signal transduction	cytosol|melanosome	transcription factor binding				0	all_cancers(14;7.43e-06)|all_epithelial(15;2.77e-08)|Lung NSC(17;6.08e-05)|all_lung(17;0.000197)		Epithelial(11;2.79e-11)|all cancers(13;5.45e-09)|OV - Ovarian serous cystadenocarcinoma(57;4.75e-05)		Ginkgo biloba(DB01381)	ATTTTCCCCTCCTTCTCCTGC	0.453		NaN											0	0	0	0.001984	0	6	88									
CSMD3	114788	broad.mit.edu	37	8	113299395	113299395	+	Missense_Mutation	SNP	T	T	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr8:113299395T>A	uc003ynu.2	-	58	9388	c.9229A>T	c.(9229-9231)ACT>TCT	p.T3077S	CSMD3_uc003yns.2_Missense_Mutation_p.T2279S|CSMD3_uc003ynt.2_Missense_Mutation_p.T3037S|CSMD3_uc011lhx.1_Missense_Mutation_p.T2908S	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3077	Extracellular (Potential).|Sushi 22.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TAACGTACAGTACTTTTAGTT	0.473		NaN								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			0	0	0	0.004482	0	9	130									
DENND3	22898	broad.mit.edu	37	8	142161801	142161801	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr8:142161801C>T	uc003yvy.2	+	7	977	c.699C>T	c.(697-699)TTC>TTT	p.F233F	DENND3_uc010mep.2_Silent_p.F246F	NM_014957	NP_055772	A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	233	DENN.									ovary(1)	1	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			CTGAGTGCTTCATGGCCTACC	0.602		NaN											0	0	0	0.013726	0	36	168									
KIFC2	90990	broad.mit.edu	37	8	145693121	145693121	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr8:145693121G>C	uc003zcz.2	+	6	705	c.640G>C	c.(640-642)GAA>CAA	p.E214Q	CYHR1_uc003zcv.2_5'Flank|CYHR1_uc003zcw.2_5'Flank|CYHR1_uc003zcx.2_5'Flank|CYHR1_uc003zcy.2_5'Flank	NM_145754	NP_665697	Q96AC6	KIFC2_HUMAN	kinesin family member C2	214	Potential.|Gln-rich.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			ovary(2)|central_nervous_system(1)	3	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			GCAGCAGCTGGAACAGCAGGA	0.647		NaN									OREG0019057	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00245	0	15	97									
PLIN2	123	broad.mit.edu	37	9	19119735	19119735	+	Silent	SNP	A	A	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr9:19119735A>T	uc003zno.2	-	6	869	c.690T>A	c.(688-690)CGT>CGA	p.R230R	PLIN2_uc011lna.1_Silent_p.R202R|PLIN2_uc011lnb.1_Missense_Mutation_p.V187E	NM_001122	NP_001113	Q99541	PLIN2_HUMAN	adipose differentiation-related protein	230					cellular lipid metabolic process	endoplasmic reticulum|extracellular region|lipid particle				ovary(2)	2						GCTGGTAGGCACGGGAGTGAA	0.433		NaN											0	0	0	0.008291	0	10	140									
PLIN2	123	broad.mit.edu	37	9	19119764	19119764	+	Nonsense_Mutation	SNP	C	C	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr9:19119764C>A	uc003zno.2	-	6	840	c.661G>T	c.(661-663)GGA>TGA	p.G221*	PLIN2_uc011lna.1_Nonsense_Mutation_p.G193*|PLIN2_uc011lnb.1_Missense_Mutation_p.W177C	NM_001122	NP_001113	Q99541	PLIN2_HUMAN	adipose differentiation-related protein	221					cellular lipid metabolic process	endoplasmic reticulum|extracellular region|lipid particle				ovary(2)	2						GACAGGGATCCCAGTCTAACA	0.413		NaN											1	0	7.48243e-07	0.006214	7.93137e-07	8	140									
PLIN2	123	broad.mit.edu	37	9	19121087	19121087	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr9:19121087G>A	uc003zno.2	-	5	565	c.386C>T	c.(385-387)TCT>TTT	p.S129F	PLIN2_uc011lna.1_Missense_Mutation_p.S101F|PLIN2_uc011lnb.1_Missense_Mutation_p.S129F	NM_001122	NP_001113	Q99541	PLIN2_HUMAN	adipose differentiation-related protein	129					cellular lipid metabolic process	endoplasmic reticulum|extracellular region|lipid particle				ovary(2)	2						GCTGGCCACAGAATCCTTGGC	0.532		NaN											0	0	0	0.001984	0	7	72									
KIAA1161	57462	broad.mit.edu	37	9	34372105	34372105	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr9:34372105C>T	uc003zue.3	-	3	1004	c.837G>A	c.(835-837)CTG>CTA	p.L279L		NM_020702	NP_065753	Q6NSJ0	K1161_HUMAN	hypothetical protein LOC57462	279	Extracellular (Potential).				carbohydrate metabolic process	integral to membrane	hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(1)|breast(1)|central_nervous_system(1)	3			LUSC - Lung squamous cell carcinoma(29;0.0107)	GBM - Glioblastoma multiforme(74;0.126)		CTCGGTAGCTCAGCTCTGGCG	0.667		NaN											0	0	0	0.000602	0	4	57									
KIAA1161	57462	broad.mit.edu	37	9	34372876	34372876	+	Silent	SNP	T	T	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr9:34372876T>C	uc003zue.3	-	2	233	c.66A>G	c.(64-66)GCA>GCG	p.A22A		NM_020702	NP_065753	Q6NSJ0	K1161_HUMAN	hypothetical protein LOC57462	22	Cytoplasmic (Potential).				carbohydrate metabolic process	integral to membrane	hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(1)|breast(1)|central_nervous_system(1)	3			LUSC - Lung squamous cell carcinoma(29;0.0107)	GBM - Glioblastoma multiforme(74;0.126)		TCTGACGCTATGCGTAGCAGC	0.637		NaN											0	0	0	0.008291	0	11	224									
TRPM3	80036	broad.mit.edu	37	9	73167853	73167853	+	Missense_Mutation	SNP	T	T	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr9:73167853T>C	uc004aid.2	-	23	3689	c.3445A>G	c.(3445-3447)ATC>GTC	p.I1149V	TRPM3_uc004ahu.2_Missense_Mutation_p.I991V|TRPM3_uc004ahv.2_Missense_Mutation_p.I951V|TRPM3_uc004ahw.2_Missense_Mutation_p.I1021V|TRPM3_uc004ahx.2_Missense_Mutation_p.I1008V|TRPM3_uc004ahy.2_Missense_Mutation_p.I1011V|TRPM3_uc004ahz.2_Missense_Mutation_p.I998V|TRPM3_uc004aia.2_Missense_Mutation_p.I996V|TRPM3_uc004aib.2_Missense_Mutation_p.I986V|TRPM3_uc004aic.2_Missense_Mutation_p.I1149V	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	1174	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						CTGAAGATGATCAGTGGTGGG	0.483		NaN											0	0	0	0.010504	0	22	202									
FRMD3	257019	broad.mit.edu	37	9	85913693	85913693	+	Missense_Mutation	SNP	T	T	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr9:85913693T>A	uc004ams.1	-	12	1242	c.1040A>T	c.(1039-1041)AAG>ATG	p.K347M	FRMD3_uc004amr.1_Missense_Mutation_p.K333M	NM_174938	NP_777598	A2A2Y4	FRMD3_HUMAN	FERM domain containing 3	347						cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			ovary(1)|central_nervous_system(1)	2						CCTCTGGATCTTGGAACTGGC	0.498		NaN											0	0	0	0.001984	0	7	61									
DAPK1	1612	broad.mit.edu	37	9	90262280	90262280	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr9:90262280C>G	uc004apc.2	+	14	1429	c.1291C>G	c.(1291-1293)CTC>GTC	p.L431V	DAPK1_uc004ape.2_Missense_Mutation_p.L431V|DAPK1_uc004apd.2_Missense_Mutation_p.L431V|DAPK1_uc011ltg.1_Missense_Mutation_p.L431V|DAPK1_uc011lth.1_Missense_Mutation_p.L168V|DAPK1_uc004apf.1_5'UTR	NM_004938	NP_004929	P53355	DAPK1_HUMAN	death-associated protein kinase 1	431	ANK 2.				apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			ovary(1)|breast(1)	2						CTTGAAATTTCTCAGTGAGAA	0.502		NaN							Chronic_Lymphocytic_Leukemia_Familial_Clustering_of				0	0	0	0.001855	0	13	69									
ALAD	210	broad.mit.edu	37	9	116152053	116152053	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr9:116152053C>T	uc011lxf.1	-	8	828	c.626G>A	c.(625-627)CGG>CAG	p.R209Q	ALAD_uc011lxe.1_Missense_Mutation_p.R192Q|ALAD_uc004bhl.3_Missense_Mutation_p.R238Q	NM_000031	NP_000022	P13716	HEM2_HUMAN	delta-aminolevulinic acid dehydratase	209		Substrate 1.			heme biosynthetic process|protein homooligomerization	cytosol	identical protein binding|lead ion binding|porphobilinogen synthase activity|zinc ion binding				0					Aminolevulinic acid(DB00855)	CCCTGCTCACCGGAAAGGGCC	0.562		NaN											0	0	0	0.001168	0	6	41									
ADAMTS13	11093	broad.mit.edu	37	9	136324257	136324257	+	Silent	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr9:136324257G>A	uc004cdv.3	+	29	4683	c.4239G>A	c.(4237-4239)CCG>CCA	p.P1413P	ADAMTS13_uc004cdp.3_3'UTR|ADAMTS13_uc004cdt.1_Silent_p.P1357P|ADAMTS13_uc004cdu.1_Silent_p.P1326P|ADAMTS13_uc004cdw.3_Silent_p.P1357P|ADAMTS13_uc004cdx.3_Silent_p.P1326P|ADAMTS13_uc004cdz.3_Silent_p.P1083P|ADAMTS13_uc004ceb.3_Silent_p.P209P|C9orf7_uc011mdg.1_5'Flank|C9orf7_uc004cec.2_5'Flank|C9orf7_uc011mdh.1_5'Flank|C9orf7_uc011mdi.1_5'Flank|C9orf7_uc010nan.2_5'Flank	NM_139025	NP_620594	Q76LX8	ATS13_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1413	CUB 2.				cell-matrix adhesion|glycoprotein metabolic process|integrin-mediated signaling pathway|peptide catabolic process|platelet activation|protein processing|proteolysis	cell surface|proteinaceous extracellular matrix	calcium ion binding|integrin binding|metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|kidney(1)	6				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		CATGGGTACCGGAGATGCAGG	0.597		NaN											0	0	0	0.004672	0	3	27									
RXRA	6256	broad.mit.edu	37	9	137328331	137328331	+	Silent	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr9:137328331C>G	uc004cfb.2	+	10	1422	c.1260C>G	c.(1258-1260)CTC>CTG	p.L420L	RXRA_uc004cfc.1_Silent_p.L323L	NM_002957	NP_002948	P19793	RXRA_HUMAN	retinoid X receptor, alpha	420	Ligand-binding.				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	AGCTCTTGCTCCGCCTGCCGG	0.612		NaN											0	0	0	0.004482	0	9	144									
ANAPC2	29882	broad.mit.edu	37	9	140074639	140074639	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr9:140074639C>G	uc004clr.1	-	10	1957	c.1884G>C	c.(1882-1884)CAG>CAC	p.Q628H	ANAPC2_uc004clq.1_Missense_Mutation_p.Q484H	NM_013366	NP_037498	Q9UJX6	ANC2_HUMAN	anaphase-promoting complex subunit 2	628					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cyclin catabolic process|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of cyclin-dependent protein kinase activity	anaphase-promoting complex|cytosol|nucleoplasm	ubiquitin protein ligase binding|ubiquitin-protein ligase activity			ovary(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.000858)		GTACCTTGAGCTGCTCATACT	0.632		NaN											0	0	0	0.000602	0	5	38									
ANAPC2	29882	broad.mit.edu	37	9	140076196	140076196	+	Missense_Mutation	SNP	C	C	T	rs142080330		TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr9:140076196C>T	uc004clr.1	-	7	1478	c.1405G>A	c.(1405-1407)GAC>AAC	p.D469N	ANAPC2_uc004clq.1_Missense_Mutation_p.D325N	NM_013366	NP_037498	Q9UJX6	ANC2_HUMAN	anaphase-promoting complex subunit 2	469					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cyclin catabolic process|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of cyclin-dependent protein kinase activity	anaphase-promoting complex|cytosol|nucleoplasm	ubiquitin protein ligase binding|ubiquitin-protein ligase activity			ovary(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.000858)		TCCTCACTGTCCTGGCCTGTC	0.652		NaN											0	0	0	0.000602	0	5	45									
MXRA5	25878	broad.mit.edu	37	X	3238516	3238516	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chrX:3238516G>C	uc004crg.3	-	5	5367	c.5210C>G	c.(5209-5211)ACT>AGT	p.T1737S		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1737						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				AAAAGAAAGAGTCTTGTTGGT	0.463		NaN											0	0	0	0.014323	0	24	28									
USP11	8237	broad.mit.edu	37	X	47092454	47092454	+	Silent	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chrX:47092454C>T	uc004dhp.2	+	1	141	c.141C>T	c.(139-141)GTC>GTT	p.V47V		NM_004651	NP_004642	P51784	UBP11_HUMAN	ubiquitin specific peptidase 11	47					protein deubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)|lung(1)|central_nervous_system(1)	3						tggcgacggtcgcagcaaatc	0.383		NaN											0	0	0	0.00308	0	7	16									
APEX2	27301	broad.mit.edu	37	X	55033806	55033806	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chrX:55033806C>T	uc004dtz.2	+	6	1571	c.1495C>T	c.(1495-1497)CGG>TGG	p.R499W	APEX2_uc011mom.1_Missense_Mutation_p.R328W	NM_014481	NP_055296	Q9UBZ4	APEX2_HUMAN	apurinic/apyrimidinic endonuclease 2	499					cell cycle|DNA recombination|DNA repair	nucleus	DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|endonuclease activity|exonuclease activity|zinc ion binding			breast(1)	1						TGCCAGGCCCCGGGGTCCTCC	0.642		NaN						Other_BER_factors					0	0	0	0.009096	0	4	13									
KLHL4	56062	broad.mit.edu	37	X	86869502	86869502	+	Missense_Mutation	SNP	A	A	G			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chrX:86869502A>G	uc004efb.2	+	3	838	c.656A>G	c.(655-657)AAA>AGA	p.K219R	KLHL4_uc004efa.2_Missense_Mutation_p.K219R	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	219	BTB.					cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						CTTGAAGCCAAACAAGAAGAG	0.378		NaN											0	0	0	0.000602	0	5	40									
ODZ1	10178	broad.mit.edu	37	X	123554332	123554332	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chrX:123554332G>A	uc004euj.2	-	24	4854	c.4790C>T	c.(4789-4791)CCG>CTG	p.P1597L	ODZ1_uc011muj.1_Missense_Mutation_p.P1603L|ODZ1_uc010nqy.2_Missense_Mutation_p.P1604L	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	1597	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						AAGCCATAGCGGCATTCCGCC	0.493		NaN											0	0	0	0.004672	0	3	42									
DCAF12L1	139170	broad.mit.edu	37	X	125685907	125685907	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chrX:125685907C>T	uc004eul.2	-	1	936	c.685G>A	c.(685-687)GAC>AAC	p.D229N		NM_178470	NP_848565	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	229	WD 2.									skin(3)|ovary(1)	4						GCAACAGTGTCATCGAACTTG	0.637		NaN											0	0	0	0.006122	0	19	42									
FAM127B	26071	broad.mit.edu	37	X	134186001	134186001	+	Missense_Mutation	SNP	C	C	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chrX:134186001C>A	uc004eyf.2	-	1	221	c.138G>T	c.(136-138)CAG>CAT	p.Q46H	FAM127B_uc004eyg.3_Missense_Mutation_p.Q46H	NM_001078172	NP_001071640	Q9BWD3	F127B_HUMAN	family with sequence similarity 127, member B	46											0	Acute lymphoblastic leukemia(192;0.000127)					AGGAGCTCGTCTGCACGATGA	0.652		NaN											1	0	2.81731e-10	0.010818	3.0473e-10	32	59									
OPN1LW	5956	broad.mit.edu	37	X	153420214	153420214	+	Silent	SNP	G	G	A	rs139583770		TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chrX:153420214G>A	uc004fjz.3	+	4	777	c.744G>A	c.(742-744)GCG>GCA	p.A248A		NM_020061	NP_064445	P04000	OPSR_HUMAN	opsin 1 (cone pigments), long-wave-sensitive	248	Cytoplasmic.				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity				0	all_cancers(53;1.83e-16)|all_epithelial(53;2.73e-10)|all_lung(58;6.39e-07)|Lung NSC(58;8.37e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCATCCGAGCGGTAAGCCCCC	0.547		NaN											0	0	0	0.00245	0	12	62									
ZZZ3	26009	broad.mit.edu	37	1	78098534	78098536	+	In_Frame_Del	DEL	AGT	AGT	-			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:78098534_78098536delAGT	uc001dhq.2	-	5	980_982	c.504_506delACT	c.(502-507)ATACTG>ATG	p.168_169IL>M	ZZZ3_uc001dhr.2_Intron|ZZZ3_uc009wbz.1_In_Frame_Del_p.168_169IL>M|ZZZ3_uc001dhp.2_In_Frame_Del_p.168_169IL>M	NM_015534	NP_056349	Q8IYH5	ZZZ3_HUMAN	zinc finger, ZZ-type containing 3	168_169					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|large_intestine(1)	5						ACAATCATCCAGTATAAGACATC	0.409		NaN											NaN	NaN	NaN	NaN	NaN	14	223	---	---							
TXNIP	10628	broad.mit.edu	37	1	145440508	145440509	+	Frame_Shift_Ins	INS	-	-	T			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08			-	T	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:145440508_145440509insT	uc001enn.3	+	5	1155_1156	c.814_815insT	c.(814-816)GTTfs	p.V272fs	NBPF10_uc001emp.3_Intron|TXNIP_uc001enm.1_Intron|TXNIP_uc010oys.1_Frame_Shift_Ins_p.V217fs	NM_006472	NP_006463	Q9H3M7	TXNIP_HUMAN	thioredoxin interacting protein	272					cell cycle|keratinocyte differentiation|transcription, DNA-dependent		ubiquitin protein ligase binding			ovary(2)	2	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CATCCTTCGAGTTGAATATTCC	0.485		NaN											NaN	NaN	NaN	NaN	NaN	20	184	---	---							
TMEM19	55266	broad.mit.edu	37	12	72094757	72094757	+	Frame_Shift_Del	DEL	T	T	-			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:72094757delT	uc001sws.2	+	6	1576	c.993delT	c.(991-993)GGTfs	p.G331fs	TMEM19_uc009zru.1_RNA	NM_018279	NP_060749	Q96HH6	TMM19_HUMAN	transmembrane protein 19	331	Helical; (Potential).					integral to membrane					0		Breast(359;0.0889)		GBM - Glioblastoma multiforme(134;0.044)		CTGCTTGGGGTTTTTGGCCCA	0.433		NaN											NaN	NaN	NaN	NaN	NaN	7	464	---	---							
GPR81	27198	broad.mit.edu	37	12	123214852	123214853	+	Frame_Shift_Ins	INS	-	-	C			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:123214852_123214853insC	uc001ucz.2	-	1	277_278	c.34_35insG	c.(34-36)GACfs	p.D12fs	GPR81_uc001ucw.1_RNA	NM_032554	NP_115943	Q9BXC0	HCAR1_HUMAN	G protein-coupled receptor 81	12	Extracellular (Potential).				response to estradiol stimulus	integral to membrane|plasma membrane	G-protein coupled receptor activity				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.14e-05)|Epithelial(86;3.25e-05)|BRCA - Breast invasive adenocarcinoma(302;0.197)		GGAGATGGTGTCCCCCTCGATG	0.619		NaN											NaN	NaN	NaN	NaN	NaN	8	53	---	---							
CHD2	1106	broad.mit.edu	37	15	93545433	93545434	+	Frame_Shift_Ins	INS	-	-	A			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr15:93545433_93545434insA	uc002bsp.2	+	33	4739_4740	c.4164_4165insA	c.(4162-4167)ATGAAAfs	p.M1388fs	CHD2_uc002bso.1_Frame_Shift_Ins_p.M1388fs	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1388_1389					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			AAAGTCCAATgaaaaaaaaaca	0.158		NaN											NaN	NaN	NaN	NaN	NaN	7	147	---	---							
TBC1D24	57465	broad.mit.edu	37	16	2546657	2546657	+	Frame_Shift_Del	DEL	G	G	-			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr16:2546657delG	uc002cql.2	+	2	648	c.508delG	c.(508-510)GACfs	p.D170fs	TBC1D24_uc002cqk.2_Frame_Shift_Del_p.D170fs|TBC1D24_uc002cqm.2_Frame_Shift_Del_p.D170fs|TBC1D24_uc010bsm.2_5'Flank	NM_020705	NP_065756	Q9ULP9	TBC24_HUMAN	TBC1 domain family, member 24	170	Rab-GAP TBC.				neuron projection development	cytoplasm	protein binding|Rab GTPase activator activity				0						GAGGCTGATCGACCAGAGCTT	0.632		NaN											NaN	NaN	NaN	NaN	NaN	7	64	---	---							
MNT	4335	broad.mit.edu	37	17	2290220	2290220	+	Frame_Shift_Del	DEL	G	G	-			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:2290220delG	uc002fur.2	-	6	1976	c.1724delC	c.(1723-1725)CCAfs	p.P575fs		NM_020310	NP_064706	Q99583	MNT_HUMAN	MAX binding protein	575					multicellular organismal development|negative regulation of cell proliferation|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			skin(1)	1				Colorectal(2;1.37e-05)|READ - Rectum adenocarcinoma(2;8.68e-05)		TGTGCTGACTGGGAAGGAGGG	0.667		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---	---							
GPR75	10936	broad.mit.edu	37	2	54080472	54080472	+	Frame_Shift_Del	DEL	G	G	-			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:54080472delG	uc002rxo.3	-	2	1693	c.1422delC	c.(1420-1422)CCCfs	p.P474fs	ASB3_uc002rxi.3_Intron	NM_006794	NP_006785	O95800	GPR75_HUMAN	G protein-coupled receptor 75	474	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|skin(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			GAGTGTTGATGGGGGTCGAGC	0.493		NaN											NaN	NaN	NaN	NaN	NaN	19	312	---	---							
DBR1	51163	broad.mit.edu	37	3	137880741	137880743	+	In_Frame_Del	DEL	TCG	TCG	-	rs150114751	byFrequency	TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:137880741_137880743delTCG	uc003erv.2	-	8	1759_1761	c.1623_1625delCGA	c.(1621-1626)GATGAT>GAT	p.541_542DD>D	DBR1_uc003eru.2_In_Frame_Del_p.490_491DD>D|DBR1_uc003ert.2_In_Frame_Del_p.309_310DD>D	NM_016216	NP_057300	Q9UK59	DBR1_HUMAN	debranching enzyme homolog 1	541_542						nucleus	metal ion binding|RNA lariat debranching enzyme activity				0						TTAAGCTGCATCGTCATCATCAT	0.251		NaN											NaN	NaN	NaN	NaN	NaN	7	110	---	---							
ARHGEF6	9459	broad.mit.edu	37	X	135814312	135814312	+	Frame_Shift_Del	DEL	T	T	-			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chrX:135814312delT	uc004fab.2	-	6	1143	c.681delA	c.(679-681)AAAfs	p.K227fs	ARHGEF6_uc011mwd.1_Frame_Shift_Del_p.K100fs|ARHGEF6_uc011mwe.1_Frame_Shift_Del_p.K73fs	NM_004840	NP_004831	Q15052	ARHG6_HUMAN	Rac/Cdc42 guanine nucleotide exchange factor 6	227					apoptosis|cell junction assembly|induction of apoptosis by extracellular signals|JNK cascade|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity				0	Acute lymphoblastic leukemia(192;0.000127)					CTTTGACGGCTTTTGGGGAGA	0.328		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---	---