Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
GLTPD1	80772	broad.mit.edu	37	1	1262754	1262754	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:1262754G>A	uc001aeo.2	+	3	671	c.256G>A	c.(256-258)GAG>AAG	p.E86K	CPSF3L_uc001aee.1_5'Flank|CPSF3L_uc001aef.1_5'Flank|CPSF3L_uc009vjz.1_5'Flank|CPSF3L_uc010nyj.1_5'Flank|CPSF3L_uc001aeg.1_5'Flank|CPSF3L_uc001aeh.1_5'Flank|CPSF3L_uc001aei.1_5'Flank|CPSF3L_uc001aej.1_5'Flank|CPSF3L_uc001aek.1_5'Flank|CPSF3L_uc001aem.1_5'Flank|CPSF3L_uc001ael.1_5'Flank|CPSF3L_uc001aen.1_5'Flank	NM_001029885	NP_001025056	Q5TA50	GLTD1_HUMAN	glycolipid transfer protein domain containing 1	86						cytoplasm	glycolipid binding|glycolipid transporter activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;4.95e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		GGTGGCCCACGAGCTGAGCAA	0.706		NaN											0	0	0	0.000602	0	5	15									
PRAMEF12	390999	broad.mit.edu	37	1	12835183	12835183	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:12835183C>T	uc001aui.2	+	1	200	c.173C>T	c.(172-174)GCC>GTC	p.A58V		NM_001080830	NP_001074299	O95522	PRA12_HUMAN	PRAME family member 12	58										ovary(3)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		ATGGTGCAGGCCTGGCCCTTC	0.577		NaN											0	0	0	0.00499	0	17	76									
UBR4	23352	broad.mit.edu	37	1	19473366	19473366	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:19473366G>T	uc001bbi.2	-	52	7762	c.7758C>A	c.(7756-7758)AAC>AAA	p.N2586K	UBR4_uc001bbk.1_Missense_Mutation_p.N240K	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	2586					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		GGACAAGGTTGTTGGGGCGCA	0.517		NaN											1	0	9.86323e-18	0.003954	1.13853e-17	25	155									
GRIK3	2899	broad.mit.edu	37	1	37271789	37271789	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:37271789C>A	uc001caz.2	-	14	2365	c.2230G>T	c.(2230-2232)GAG>TAG	p.E744*	GRIK3_uc001cba.1_Nonsense_Mutation_p.E744*	NM_000831	NP_000822	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	744	Extracellular (Potential).				negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)|breast(1)	7		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	GTGACGTACTCGATGGTGGTG	0.637		NaN											1	0	1.66031e-10	0.003954	1.83714e-10	21	34									
RLF	6018	broad.mit.edu	37	1	40704314	40704314	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:40704314C>A	uc001cfc.3	+	8	3971	c.3940C>A	c.(3940-3942)CAT>AAT	p.H1314N	RLF_uc001cfd.3_Missense_Mutation_p.H1005N	NM_012421	NP_036553	Q13129	RLF_HUMAN	rearranged L-myc fusion	1314	C2H2-type 10.				chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			ovary(2)|pancreas(1)	3	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			CCATTGTATTCATAAAACTTG	0.368		NaN											1	0	1.12685e-05	0.004482	1.17721e-05	8	37									
TNNI3K	51086	broad.mit.edu	37	1	74801782	74801782	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:74801782G>C	uc001dgf.1	+	7	682	c.631G>C	c.(631-633)GGA>CGA	p.G211R	TNNI3K_uc001dgc.1_Missense_Mutation_p.G312R|TNNI3K_uc001dgd.2_Missense_Mutation_p.G312R|TNNI3K_uc001dge.1_Missense_Mutation_p.G312R	NM_015978	NP_057062	Q59H18	TNI3K_HUMAN	TNNI3 interacting kinase isoform b	211	ANK 5.					cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding			large_intestine(4)|lung(3)|ovary(2)|upper_aerodigestive_tract(1)	10						ATCTGCAAAAGGATTCTTGAA	0.358		NaN											0	0	0	0.014323	0	23	41									
RPF1	80135	broad.mit.edu	37	1	84944970	84944970	+	Silent	SNP	G	G	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:84944970G>T	uc001djv.3	+	1	51	c.6G>T	c.(4-6)GCG>GCT	p.A2A		NM_025065	NP_079341	Q9H9Y2	RPF1_HUMAN	RNA processing factor 1	2					rRNA processing|translation	nucleolus	aminoacyl-tRNA ligase activity|ATP binding|rRNA binding				0						AGACCATGGCGAAAGCCGGGG	0.552		NaN											1	0	1.61879e-10	0.013537	1.80187e-10	11	19									
RPL5	6125	broad.mit.edu	37	1	93300335	93300335	+	Splice_Site	SNP	G	G	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:93300335G>A	uc001doz.2	+	4	268	c.190_splice	c.e4-1	p.I64_splice	FAM69A_uc001dpc.2_Intron|RPL5_uc001dpa.2_Splice_Site|RPL5_uc001dpb.2_Splice_Site_p.I14_splice|RPL5_uc001dpd.2_5'Flank|SNORD21_uc001dpe.2_5'Flank	NM_000969	NP_000960	P46777	RL5_HUMAN	ribosomal protein L5						endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	5S rRNA binding|protein binding|structural constituent of ribosome				0		all_lung(203;0.00265)|Lung NSC(277;0.0056)|all_neural(321;0.185)|Melanoma(281;0.192)|Glioma(108;0.203)		GBM - Glioblastoma multiforme(16;0.000305)|all cancers(265;0.000343)|Epithelial(280;0.0927)		TCTTACTATAGATTGCTTATG	0.388		NaN											0	0	0	0.01441	0	67	80									
MYBPHL	343263	broad.mit.edu	37	1	109838858	109838858	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:109838858G>A	uc001dxk.1	-	6	915	c.865C>T	c.(865-867)CGG>TGG	p.R289W	MYBPHL_uc010ovh.1_Missense_Mutation_p.R266W|MYBPHL_uc001dxl.2_Intron	NM_001010985	NP_001010985	A2RUH7	MBPHL_HUMAN	myosin binding protein H-like	289	Ig-like C2-type 2.									ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_lung(203;0.00519)|all_epithelial(167;0.00575)|Lung NSC(277;0.00822)		Colorectal(144;0.0306)|Lung(183;0.0681)|COAD - Colon adenocarcinoma(174;0.117)|Epithelial(280;0.197)|all cancers(265;0.225)		CCACTCACCCGGGGAGAGGCG	0.562		NaN											0	0	0	0.009718	0	43	102									
SPAG17	200162	broad.mit.edu	37	1	118623868	118623868	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:118623868G>C	uc001ehk.2	-	15	2133	c.2065C>G	c.(2065-2067)CGA>GGA	p.R689G		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	689						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		GAAGGTTCTCGGTTGCTTTCA	0.363		NaN											0	0	0	0.00333	0	22	126									
ANKRD35	148741	broad.mit.edu	37	1	145563013	145563013	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:145563013C>T	uc001eob.1	+	10	2809	c.2701C>T	c.(2701-2703)CGC>TGC	p.R901C	NBPF10_uc001emp.3_Intron|ANKRD35_uc010oyx.1_Missense_Mutation_p.R744C	NM_144698	NP_653299	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	901	Potential.									ovary(4)|skin(1)	5	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GATGCGGGGGCGCTCCGAGCA	0.667		NaN											0	0	0	0.004482	0	9	36									
GPR89B	51463	broad.mit.edu	37	1	147400669	147400669	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:147400669C>G	uc001epv.3	+	1	164	c.20C>G	c.(19-21)TCC>TGC	p.S7C	GPR89B_uc010ozs.1_Missense_Mutation_p.S7C|GPR89B_uc010ozt.1_5'UTR|GPR89B_uc010ozu.1_5'UTR|GPR89B_uc001epw.3_5'UTR|GPR89B_uc010ozv.1_5'Flank	NM_016334	NP_057418	B7ZAQ6	GPHRA_HUMAN	G protein-coupled receptor 89B	7	Helical; (Potential).				intracellular pH reduction|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein transport	Golgi cisterna membrane|Golgi-associated vesicle membrane|integral to membrane	signal transducer activity|voltage-gated anion channel activity				0	all_hematologic(923;0.0276)					CTGATCGACTCCAGCATCATG	0.662		NaN											0	0	0	0.005443	0	24	58									
HIST2H2AC	8338	broad.mit.edu	37	1	149858559	149858559	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:149858559G>T	uc001etd.2	+	1	35	c.35G>T	c.(34-36)CGC>CTC	p.R12L	HIST2H2BE_uc001etc.2_5'Flank	NM_003517	NP_003508	Q16777	H2A2C_HUMAN	histone cluster 2, H2ac	12					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|skin(1)	2	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			GGCAAGGCCCGCGCCAAGGCC	0.582		NaN											1	0	3.76054e-38	0.01441	4.5369e-38	74	111									
ATP1A4	480	broad.mit.edu	37	1	160143967	160143967	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:160143967G>C	uc001fve.3	+	14	2537	c.2058G>C	c.(2056-2058)CAG>CAC	p.Q686H	ATP1A4_uc001fvf.3_RNA|ATP1A4_uc001fvg.2_Missense_Mutation_p.Q189H	NM_144699	NP_653300	Q13733	AT1A4_HUMAN	Na+/K+ -ATPase alpha 4 subunit isoform 1	686	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(2)|skin(2)	4	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			agcttgatcagatcctccaga	0.199		NaN											0	0	0	0.012319	0	18	70									
ATP1A4	480	broad.mit.edu	37	1	160143998	160143998	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:160143998G>C	uc001fve.3	+	14	2568	c.2089G>C	c.(2089-2091)GCT>CCT	p.A697P	ATP1A4_uc001fvf.3_RNA|ATP1A4_uc001fvg.2_Missense_Mutation_p.A200P	NM_144699	NP_653300	Q13733	AT1A4_HUMAN	Na+/K+ -ATPase alpha 4 subunit isoform 1	697	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(2)|skin(2)	4	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			gatcgtgtttgctcgGACCTC	0.264		NaN											0	0	0	0.006122	0	16	79									
ATP1A4	480	broad.mit.edu	37	1	160146388	160146388	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:160146388G>C	uc001fve.3	+	17	3065	c.2586G>C	c.(2584-2586)CAG>CAC	p.Q862H	ATP1A4_uc001fvf.3_Intron|ATP1A4_uc001fvg.2_Missense_Mutation_p.Q365H|ATP1A4_uc001fvh.2_5'Flank	NM_144699	NP_653300	Q13733	AT1A4_HUMAN	Na+/K+ -ATPase alpha 4 subunit isoform 1	862	Helical; (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(2)|skin(2)	4	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CCTATGGACAGATTGGTGCGC	0.527		NaN											0	0	0	0.00499	0	15	45									
HSPA6	3310	broad.mit.edu	37	1	161495361	161495361	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:161495361G>C	uc001gap.2	+	2	1573	c.913G>C	c.(913-915)GAG>CAG	p.E305Q	HSPA6_uc001gaq.2_Missense_Mutation_p.E305Q	NM_002155	NP_002146	P17066	HSP76_HUMAN	heat shock 70kDa protein 6 (HSP70B')	305					response to unfolded protein		ATP binding			skin(1)	1	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			TGCCCGCTTTGAGGAACTGTG	0.627		NaN											0	0	0	0.010504	0	20	19									
ZBTB37	84614	broad.mit.edu	37	1	173839474	173839474	+	Missense_Mutation	SNP	T	T	G			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:173839474T>G	uc009wwp.1	+	3	387	c.111T>G	c.(109-111)AAT>AAG	p.N37K	GAS5_uc001gjj.2_5'Flank|GAS5_uc001gjk.2_5'Flank|SNORD74_uc001gjo.1_5'Flank|ZBTB37_uc001gjp.1_Missense_Mutation_p.N37K|ZBTB37_uc001gjq.3_Missense_Mutation_p.N37K|ZBTB37_uc001gjr.2_Missense_Mutation_p.N37K	NM_001122770	NP_001116242	Q5TC79	ZBT37_HUMAN	zinc finger and BTB domain containing 37 isoform	37	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTGTGGTCAATGTGCAAGGAC	0.507		NaN											0	0	0	0.004878	0	39	92									
HMCN1	83872	broad.mit.edu	37	1	185987360	185987360	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:185987360G>C	uc001grq.1	+	34	5575	c.5346G>C	c.(5344-5346)AAG>AAC	p.K1782N		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	1782	Ig-like C2-type 15.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						ATGGATTCAAGATTTTATTAA	0.398		NaN											0	0	0	0.008361	0	30	90									
CFHR5	81494	broad.mit.edu	37	1	196967415	196967415	+	Missense_Mutation	SNP	T	T	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:196967415T>A	uc001gts.3	+	7	1256	c.1128T>A	c.(1126-1128)AAT>AAA	p.N376K		NM_030787	NP_110414	Q9BXR6	FHR5_HUMAN	complement factor H-related 5 precursor	376	Sushi 6.				complement activation, alternative pathway	extracellular region				breast(1)|skin(1)	2						GGAAATGGAATCCTGAAGTAG	0.294		NaN											0	0	0	0.013537	0	10	29									
ZP4	57829	broad.mit.edu	37	1	238048117	238048117	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:238048117G>T	uc001hym.2	-	10	1342	c.1342C>A	c.(1342-1344)CAG>AAG	p.Q448K	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	448	ZP.|Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			TCAGCAGGCTGGCAGACTGAC	0.498		NaN											1	0	2.74318e-10	0.006214	3.0175e-10	9	23									
OR2T12	127064	broad.mit.edu	37	1	248458286	248458286	+	Missense_Mutation	SNP	T	T	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:248458286T>A	uc010pzj.1	-	1	595	c.595A>T	c.(595-597)ATC>TTC	p.I199F		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	199	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			ACACAGCAGATGTACATGGCG	0.537		NaN											0	0	0	0.004007	0	15	79									
OR2G6	391211	broad.mit.edu	37	1	248685648	248685648	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:248685648G>A	uc001ien.1	+	1	701	c.701G>A	c.(700-702)CGC>CAC	p.R234H		NM_001013355	NP_001013373	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G,	234	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GCTGCGGGCCGCCAAAAGGCC	0.473		NaN											0	0	0	0.008871	0	21	58									
SLC39A12	221074	broad.mit.edu	37	10	18292239	18292239	+	Silent	SNP	C	C	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr10:18292239C>A	uc001ipo.2	+	12	2172	c.1899C>A	c.(1897-1899)ATC>ATA	p.I633I	SLC39A12_uc001ipn.2_Silent_p.I596I|SLC39A12_uc001ipp.2_Silent_p.I632I|SLC39A12_uc010qck.1_Silent_p.I499I|uc001ipq.1_RNA	NM_001145195	NP_001138667	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter),	633	Helical; (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)|breast(1)	2						AAGACTGGATCTTCACAGTCA	0.393		NaN											1	0	1.13049e-35	0.01441	1.35514e-35	93	112									
WAPAL	23063	broad.mit.edu	37	10	88259960	88259960	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr10:88259960C>A	uc001kdo.2	-	3	1482	c.1040G>T	c.(1039-1041)AGT>ATT	p.S347I	WAPAL_uc001kdn.2_Missense_Mutation_p.S390I|WAPAL_uc009xsw.2_Missense_Mutation_p.S347I	NM_015045	NP_055860	Q7Z5K2	WAPL_HUMAN	wings apart-like homolog	347	Mediates interaction with the cohesin complex.				cell division|interspecies interaction between organisms|mitosis|negative regulation of chromatin binding|negative regulation of DNA replication|negative regulation of sister chromatid cohesion|protein localization to chromatin|regulation of cohesin localization to chromatin	chromatin|cohesin complex|cytoplasm	protein binding			ovary(1)	1						CCCTCTAAAACTGGTCCCACA	0.463		NaN											1	0	7.88023e-25	0.01441	9.21002e-25	45	48									
OR51M1	390059	broad.mit.edu	37	11	5410829	5410829	+	Silent	SNP	G	G	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr11:5410829G>T	uc010qzc.1	+	1	201	c.201G>T	c.(199-201)CTG>CTT	p.L67L	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004756	NP_001004756	B2RNI9	B2RNI9_HUMAN	olfactory receptor, family 51, subfamily M,	67						integral to membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.98e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACCCTCGTCTGCACACACCCA	0.463		NaN											1	0	1.33834e-09	0.007413	1.46356e-09	20	75									
DBX1	120237	broad.mit.edu	37	11	20178183	20178183	+	Silent	SNP	C	C	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr11:20178183C>T	uc001mpw.1	-	4	726	c.726G>A	c.(724-726)GCG>GCA	p.A242A		NM_001029865	NP_001025036	A6NMT0	DBX1_HUMAN	developing brain homeobox 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CTCCGGGGGACGCACGGGGGC	0.622		NaN											0	0	0	0.007413	0	19	18									
OR4P4	81300	broad.mit.edu	37	11	55406051	55406051	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr11:55406051C>T	uc010rij.1	+	1	218	c.218C>T	c.(217-219)TCC>TTC	p.S73F		NM_001004124	NP_001004124	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P,	73	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						TGCTACACATCCACAGTGACC	0.398		NaN											0	0	0	0.01441	0	49	99									
OR5W2	390148	broad.mit.edu	37	11	55681672	55681672	+	Silent	SNP	G	G	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr11:55681672G>T	uc010rir.1	-	1	387	c.387C>A	c.(385-387)CCC>CCA	p.P129P		NM_001001960	NP_001001960	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W,	129	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TATAGAGCAGGGGGTTGATGA	0.463		NaN											1	0	2.20262e-25	0.013726	2.5905e-25	34	47									
MPEG1	219972	broad.mit.edu	37	11	58979792	58979792	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr11:58979792C>G	uc001nnu.3	-	1	703	c.547G>C	c.(547-549)GAG>CAG	p.E183Q		NM_001039396	NP_001034485	Q2M385	MPEG1_HUMAN	macrophage expressed gene 1 precursor	183	MACPF.|Extracellular (Potential).					integral to membrane				ovary(1)|skin(1)	2		all_epithelial(135;0.125)				TGGTTGTTCTCTAGACGGTCA	0.507		NaN											0	0	0	0.004289	0	36	90									
RASGRP2	10235	broad.mit.edu	37	11	64494818	64494818	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr11:64494818C>A	uc009ypu.2	-	16	2013	c.1786G>T	c.(1786-1788)GAG>TAG	p.E596*	RASGRP2_uc001oat.2_Nonsense_Mutation_p.E499*|RASGRP2_uc001oau.2_Nonsense_Mutation_p.E452*|RASGRP2_uc009ypv.2_Nonsense_Mutation_p.E596*|RASGRP2_uc009ypw.2_Nonsense_Mutation_p.E596*	NM_001098671	NP_001092141	Q7LDG7	GRP2_HUMAN	RAS guanyl releasing protein 2	596					platelet activation|Ras protein signal transduction|regulation of cell growth|regulation of small GTPase mediated signal transduction	cell junction|cytosol|ruffle membrane|synapse|synaptosome	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity				0						GTCTGTACCTCCTCCTCACGG	0.597		NaN											1	0	3.09899e-07	0.004482	3.36925e-07	9	49									
PYGM	5837	broad.mit.edu	37	11	64519519	64519519	+	Missense_Mutation	SNP	A	A	G			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr11:64519519A>G	uc001oax.3	-	14	2462	c.1645T>C	c.(1645-1647)TAC>CAC	p.Y549H	PYGM_uc001oay.3_Missense_Mutation_p.Y461H	NM_005609	NP_005600	P11217	PYGM_HUMAN	muscle glycogen phosphorylase isoform 1	549					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			ovary(2)	2					Pyridoxal Phosphate(DB00114)	CTCTCTAGGTAGGCAGCAAAC	0.517		NaN											0	0	0	0.01441	0	50	118									
PCNXL3	399909	broad.mit.edu	37	11	65392689	65392689	+	Silent	SNP	T	T	C			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr11:65392689T>C	uc001oey.2	+	17	2967	c.2967T>C	c.(2965-2967)TGT>TGC	p.C989C	PCNXL3_uc009yqn.2_5'UTR|PCNXL3_uc001oez.2_5'Flank	NM_032223	NP_115599	Q9H6A9	PCX3_HUMAN	pecanex-like 3	989	Helical; (Potential).					integral to membrane					0						CAGTCTTCTGTGGCCTCCTGG	0.642		NaN											0	0	0	0.004482	0	7	16									
BUD13	84811	broad.mit.edu	37	11	116628530	116628531	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr11:116628530_116628531CC>AA	uc001ppn.2	-	8	1669_1670	c.1635_1636GG>TT	c.(1633-1638)ATGGCC>ATTTCC	p.545_546MA>IS	BUD13_uc001ppo.2_Missense_Mutation_p.411_412MA>IS	NM_032725	NP_116114	Q9BRD0	BUD13_HUMAN	BUD13 homolog isoform 1	545_546										large_intestine(1)|pancreas(1)	2	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)		ATGAAGTTGGCCATAGGGTCCC	0.45		NaN											0	0	0	0.004672	0	89	153									
OPCML	4978	broad.mit.edu	37	11	132307139	132307139	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr11:132307139C>T	uc001qgs.2	-	4	691	c.641G>A	c.(640-642)CGG>CAG	p.R214Q	OPCML_uc001qgu.2_Missense_Mutation_p.R207Q|OPCML_uc010sck.1_Missense_Mutation_p.R214Q|OPCML_uc001qgt.2_Missense_Mutation_p.R213Q|OPCML_uc010scl.1_Missense_Mutation_p.R173Q	NM_002545	NP_002536	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion	214	Ig-like C2-type 2.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			ovary(2)|skin(1)	3	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		TTTTACTTTCCGCACATCGGG	0.542		NaN											0	0	0	0.008871	0	16	68									
ABCD2	225	broad.mit.edu	37	12	40013068	40013068	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr12:40013068C>T	uc001rmb.2	-	1	776	c.350G>A	c.(349-351)AGA>AAA	p.R117K		NM_005164	NP_005155	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D, member 2	117	ABC transmembrane type-1.|Interaction with PEX19.|Helical; (Potential).				fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)|central_nervous_system(1)|skin(1)	6						AAGAAAGGTTCTTGAGATTAG	0.413		NaN											0	0	0	0.012319	0	23	62									
KSR2	283455	broad.mit.edu	37	12	117914394	117914394	+	Silent	SNP	C	C	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr12:117914394C>T	uc001two.2	-	17	2425	c.2370G>A	c.(2368-2370)GAG>GAA	p.E790E		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	819	Protein kinase.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GCAGTTTGTCCTCCCGCCTGG	0.602		NaN											0	0	0	0.009096	0	3	7									
CLIP1	6249	broad.mit.edu	37	12	122818658	122818658	+	Splice_Site	SNP	C	C	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr12:122818658C>T	uc001ucg.1	-	13	2733	c.2627_splice	c.e13-1	p.E876_splice	CLIP1_uc001uch.1_Splice_Site_p.E865_splice|CLIP1_uc001uci.1_Splice_Site_p.E830_splice|CLIP1_uc001ucj.1_Splice_Site_p.E451_splice	NM_002956	NP_002947	P30622	CLIP1_HUMAN	restin isoform a						mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			ovary(2)|breast(1)	3	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		TTTACAGTTTCTATTTAGGAT	0.343		NaN											0	0	0	0.000602	0	5	17									
DNAH10	196385	broad.mit.edu	37	12	124265822	124265822	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr12:124265822C>G	uc001uft.3	+	6	659	c.634C>G	c.(634-636)CAA>GAA	p.Q212E		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	212	Stem (By similarity).|Potential.				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		AAGTAATATTCAAAGAACCAT	0.313		NaN											0	0	0	0.01441	0	68	100									
DNAH10	196385	broad.mit.edu	37	12	124359912	124359912	+	Silent	SNP	G	G	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr12:124359912G>A	uc001uft.3	+	46	7744	c.7719G>A	c.(7717-7719)AAG>AAA	p.K2573K		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2573	AAA 3 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CAATGGGAAAGGCTGGAGGAG	0.438		NaN											0	0	0	0.001984	0	7	32									
ARHGEF7	8874	broad.mit.edu	37	13	111929950	111929950	+	Missense_Mutation	SNP	A	A	C			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr13:111929950A>C	uc001vrs.2	+	14	1749	c.1499A>C	c.(1498-1500)TAT>TCT	p.Y500S	ARHGEF7_uc001vrr.2_Missense_Mutation_p.Y479S|ARHGEF7_uc001vrt.2_Missense_Mutation_p.Y450S|ARHGEF7_uc010tjn.1_RNA|ARHGEF7_uc001vru.1_Missense_Mutation_p.Y322S|ARHGEF7_uc001vrv.3_Missense_Mutation_p.Y322S|ARHGEF7_uc001vrw.3_Missense_Mutation_p.Y322S|ARHGEF7_uc001vrx.3_Missense_Mutation_p.Y322S|ARHGEF7_uc010tjo.1_Missense_Mutation_p.Y397S|ARHGEF7_uc010tjp.1_Missense_Mutation_p.Y244S	NM_001113511	NP_001106983	Q14155	ARHG7_HUMAN	PAK-interacting exchange factor beta isoform c	500	PH.				apoptosis|epidermal growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_lung(23;3.96e-05)|Lung NSC(43;0.00156)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.188)			AATGAAAGATATCTTCTACTC	0.279		NaN											0	0	0	0.004656	0	25	44									
OR4M1	441670	broad.mit.edu	37	14	20249177	20249177	+	Silent	SNP	T	T	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr14:20249177T>A	uc010tku.1	+	1	696	c.696T>A	c.(694-696)GGT>GGA	p.G232G		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	232	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CAGGCTCAGGTGAGAATACCA	0.463		NaN											0	0	0	0.01441	0	61	167									
NUBPL	80224	broad.mit.edu	37	14	32315779	32315779	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr14:32315779C>T	uc001wrk.3	+	9	851	c.796C>T	c.(796-798)CTT>TTT	p.L266F	NUBPL_uc010amj.2_RNA|NUBPL_uc010tpl.1_Missense_Mutation_p.L170F	NM_025152	NP_079428	Q8TB37	NUBPL_HUMAN	nucleotide binding protein-like	266					mitochondrial respiratory chain complex I assembly|mitochondrion morphogenesis	mitochondrion	4 iron, 4 sulfur cluster binding|ATP binding|metal ion binding				0	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.214)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0677)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0102)		AGCACAGACCCTTGGTCTTGA	0.428		NaN											0	0	0	0.001168	0	6	12									
STOML1	9399	broad.mit.edu	37	15	74281034	74281034	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr15:74281034C>T	uc002awe.2	-	4	571	c.500G>A	c.(499-501)CGC>CAC	p.R167H	STOML1_uc002awf.2_Missense_Mutation_p.R167H|STOML1_uc010bje.2_Missense_Mutation_p.R167H|STOML1_uc010uld.1_Missense_Mutation_p.R125H|STOML1_uc002awh.2_Missense_Mutation_p.R117H|STOML1_uc002awg.2_Missense_Mutation_p.R117H|STOML1_uc002awi.2_Missense_Mutation_p.R80H	NM_004809	NP_004800	Q9UBI4	STML1_HUMAN	stomatin (EPB72)-like 1	167	Cytoplasmic (Potential).					integral to membrane	sterol binding			skin(1)	1						GGCTGTCATGCGTGTGGCTGT	0.602		NaN											0	0	0	0.007835	0	43	34									
SRRM2	23524	broad.mit.edu	37	16	2813316	2813316	+	Silent	SNP	C	C	T	rs137907192	byFrequency	TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr16:2813316C>T	uc002crk.2	+	11	3336	c.2787C>T	c.(2785-2787)AGC>AGT	p.S929S	SRRM2_uc002crj.1_Silent_p.S833S|SRRM2_uc002crl.1_Silent_p.S929S|SRRM2_uc010bsu.1_Silent_p.S833S	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	929	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						GACAAAGAAGCCATTCTGGCT	0.493		NaN											0	0	0	0.001984	0	6	93									
A2BP1	54715	broad.mit.edu	37	16	7645613	7645613	+	Silent	SNP	C	C	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr16:7645613C>T	uc002cys.2	+	8	1519	c.531C>T	c.(529-531)CAC>CAT	p.H177H	A2BP1_uc010buf.1_Silent_p.H177H|A2BP1_uc002cyr.1_Silent_p.H176H|A2BP1_uc002cyt.2_Silent_p.H177H|A2BP1_uc010uxz.1_Silent_p.H220H|A2BP1_uc010uya.1_Intron|A2BP1_uc002cyv.1_Silent_p.H177H|A2BP1_uc010uyb.1_Silent_p.H177H|A2BP1_uc002cyw.2_Silent_p.H197H|A2BP1_uc002cyy.2_Silent_p.H197H|A2BP1_uc002cyx.2_Silent_p.H197H|A2BP1_uc010uyc.1_Silent_p.H197H	NM_018723	NP_061193	Q9NWB1	RFOX1_HUMAN	ataxin 2-binding protein 1 isoform 4	177	RRM.				mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding				0		all_cancers(2;4.54e-52)|Colorectal(2;6.95e-44)|all_epithelial(2;1.15e-37)|Lung NSC(2;0.000289)|all_lung(2;0.00148)|Myeloproliferative disorder(2;0.0122)|Medulloblastoma(2;0.0354)|all_neural(2;0.0381)|all_hematologic(2;0.0749)|Renal(2;0.0758)|Melanoma(2;0.211)		Colorectal(1;3.55e-51)|COAD - Colon adenocarcinoma(2;1.92e-46)|all cancers(1;5.36e-16)|Epithelial(1;3.98e-15)|READ - Rectum adenocarcinoma(2;3.71e-05)|GBM - Glioblastoma multiforme(1;0.0499)		AGAAATTACACGGCACCGTGG	0.448		NaN											0	0	0	0.00333	0	23	92									
DNAH3	55567	broad.mit.edu	37	16	21061283	21061283	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr16:21061283C>T	uc010vbe.1	-	30	4295	c.4295G>A	c.(4294-4296)GGG>GAG	p.G1432E		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1432	ATP (Potential).|AAA 1 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		CTTGCCAGTCCCAGCTGGACC	0.522		NaN											0	0	0	0.001855	0	13	67									
SHCBP1	79801	broad.mit.edu	37	16	46638001	46638001	+	Silent	SNP	G	G	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr16:46638001G>T	uc002eec.3	-	7	1018	c.978C>A	c.(976-978)TCC>TCA	p.S326S		NM_024745	NP_079021	Q8NEM2	SHCBP_HUMAN	SHC SH2-domain binding protein 1	326										ovary(1)|breast(1)	2		all_cancers(37;0.00404)|all_epithelial(9;0.00527)|all_lung(18;0.0413)|Lung NSC(13;0.213)				TCTGACCGCTGGAACGGACAC	0.493		NaN											1	0	4.4004e-07	0.00333	4.72917e-07	25	92									
CNOT1	23019	broad.mit.edu	37	16	58620581	58620581	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr16:58620581G>A	uc002env.2	-	7	798	c.505C>T	c.(505-507)CAA>TAA	p.Q169*	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Nonsense_Mutation_p.Q169*|CNOT1_uc002enx.2_Nonsense_Mutation_p.Q169*|CNOT1_uc002enz.1_Intron	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	169					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		CCACCTTCTTGATTTCCACTG	0.473		NaN											0	0	0	0.01441	0	119	165									
WWOX	51741	broad.mit.edu	37	16	78198152	78198152	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr16:78198152C>T	uc002ffk.2	+	5	607	c.482C>T	c.(481-483)GCG>GTG	p.A161V	WWOX_uc010vnk.1_Missense_Mutation_p.A48V|WWOX_uc002ffl.2_Missense_Mutation_p.A161V|WWOX_uc010che.2_Intron|WWOX_uc002ffj.1_Missense_Mutation_p.A161V	NM_016373	NP_057457	Q9NZC7	WWOX_HUMAN	WW domain-containing oxidoreductase isoform 1	161	Interaction with MAPT (By similarity).				apoptosis|negative regulation of Wnt receptor signaling pathway|steroid metabolic process|Wnt receptor signaling pathway	Golgi apparatus|mitochondrion|nucleus	coenzyme binding|oxidoreductase activity|protein dimerization activity				0		all_cancers(2;1.97e-181)|all_epithelial(2;3.85e-160)|all_lung(2;2.03e-39)|Lung NSC(2;7.16e-35)|Colorectal(2;6.96e-21)|all_hematologic(2;1.13e-16)|Melanoma(2;5.16e-06)|all_neural(2;8.84e-06)|Renal(2;5.26e-05)|Medulloblastoma(2;0.00498)|Breast(2;0.00631)|Lung SC(2;0.0261)|Prostate(104;0.167)		UCEC - Uterine corpus endometrioid carcinoma (2;0.012)|Epithelial(1;2.65e-39)|all cancers(1;3.26e-34)|STAD - Stomach adenocarcinoma(1;5.1e-20)|COAD - Colon adenocarcinoma(1;1.04e-11)|Colorectal(1;3.4e-11)|OV - Ovarian serous cystadenocarcinoma(1;1.01e-10)|BRCA - Breast invasive adenocarcinoma(1;0.00196)|Kidney(780;0.232)		ATGGCAAGGGCGAGTGAAGCA	0.448		NaN											0	0	0	0.000602	0	4	28									
SMYD4	114826	broad.mit.edu	37	17	1690224	1690224	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr17:1690224C>A	uc002ftm.3	-	7	1932	c.1764G>T	c.(1762-1764)AAG>AAT	p.K588N	SMYD4_uc002ftn.1_Missense_Mutation_p.K443N	NM_052928	NP_443160	Q8IYR2	SMYD4_HUMAN	SET and MYND domain containing 4	588							zinc ion binding			skin(3)|kidney(2)	5						GAGACCTCAGCTTCTGCTGCC	0.542		NaN											1	0	1.49906e-05	0.00245	1.55736e-05	13	18									
CCDC42	146849	broad.mit.edu	37	17	8638796	8638796	+	Missense_Mutation	SNP	T	T	C			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr17:8638796T>C	uc002gln.2	-	5	853	c.626A>G	c.(625-627)GAA>GGA	p.E209G	CCDC42_uc002glo.2_Intron	NM_144681	NP_653282	Q96M95	CCD42_HUMAN	coiled-coil domain containing 42 isoform 1	209	Potential.			Missing (in Ref. 2; AAH29224).						ovary(1)	1						ATCATCCTTTTCCTCCATGTA	0.562		NaN											0	0	0	0.00308	0	8	35									
BRIP1	83990	broad.mit.edu	37	17	59821938	59821938	+	Silent	SNP	T	T	C			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr17:59821938T>C	uc002izk.1	-	15	2253	c.2112A>G	c.(2110-2112)TTA>TTG	p.L704L	BRIP1_uc002izl.1_Silent_p.L85L	NM_032043	NP_114432	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	704					DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(1)	1						AACGTTCTTTTAATTTTTCTA	0.308		NaN	F|N|Mis			AML|leukemia|breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.01441	0	66	108									
PTPN2	5771	broad.mit.edu	37	18	12794331	12794331	+	Silent	SNP	A	A	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr18:12794331A>T	uc002krp.2	-	9	1388	c.1194T>A	c.(1192-1194)ATT>ATA	p.I398I	PTPN2_uc002krl.2_Intron|PTPN2_uc002krn.2_Intron|PTPN2_uc002kro.2_Intron|PTPN2_uc002krm.2_Intron	NM_002828	NP_002819	P17706	PTN2_HUMAN	protein tyrosine phosphatase, non-receptor type	398					interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway	endoplasmic reticulum|nucleoplasm	protein binding			skin(2)	2		Lung NSC(161;8.94e-06)				CGCCAACCAAAATGACTGACA	0.398		NaN											0	0	0	0.012319	0	20	79									
WDR7	23335	broad.mit.edu	37	18	54694285	54694285	+	Silent	SNP	G	G	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr18:54694285G>A	uc002lgk.1	+	28	4531	c.4320G>A	c.(4318-4320)CAG>CAA	p.Q1440Q	WDR7_uc002lgl.1_Silent_p.Q1407Q	NM_015285	NP_056100	Q9Y4E6	WDR7_HUMAN	rabconnectin-3 beta isoform 1	1440										ovary(2)|skin(1)	3				Lung(128;0.0238)|Colorectal(16;0.0296)		CGGCACCTCAGCTGCGCTGCA	0.607		NaN											0	0	0	0.007835	0	41	32									
GALR1	2587	broad.mit.edu	37	18	74980672	74980672	+	Silent	SNP	C	C	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr18:74980672C>T	uc002lms.3	+	3	1361	c.864C>T	c.(862-864)GCC>GCT	p.A288A		NM_001480	NP_001471	P47211	GALR1_HUMAN	galanin receptor 1	288	Helical; Name=7; (Potential).				digestion|negative regulation of adenylate cyclase activity	integral to membrane|plasma membrane	galanin receptor activity			lung(1)	1		Prostate(75;0.0865)|Esophageal squamous(42;0.129)|Melanoma(33;0.211)		OV - Ovarian serous cystadenocarcinoma(15;1.03e-06)|BRCA - Breast invasive adenocarcinoma(31;0.104)		GAATCACCGCCCACTGCCTGG	0.493		NaN											0	0	0	0.01441	0	49	28									
AP3D1	8943	broad.mit.edu	37	19	2121015	2121015	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr19:2121015C>A	uc002luz.2	-	14	1550	c.1327G>T	c.(1327-1329)GAC>TAC	p.D443Y	AP3D1_uc002luy.2_Missense_Mutation_p.D352Y|AP3D1_uc002lva.2_Missense_Mutation_p.D443Y	NM_003938	NP_003929	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1	443	HEAT 9.				eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ATGGCCACGTCCAGCATTTGG	0.652		NaN											1	0	4.3838e-07	0.001855	4.72917e-07	12	50									
FBN3	84467	broad.mit.edu	37	19	8161817	8161817	+	Silent	SNP	G	G	A	rs138081025		TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr19:8161817G>A	uc002mjf.2	-	42	5382	c.5361C>T	c.(5359-5361)TAC>TAT	p.Y1787Y		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	1787	EGF-like 27; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						ACTTGCAGCGGTAGCTACCGG	0.607		NaN											0	0	0	0.00278	0	25	55									
GATAD2A	54815	broad.mit.edu	37	19	19612809	19612809	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr19:19612809G>A	uc010xqt.1	+	10	1844	c.1532G>A	c.(1531-1533)CGC>CAC	p.R511H	GATAD2A_uc010xqu.1_Missense_Mutation_p.R140H|GATAD2A_uc010xqv.1_Missense_Mutation_p.R531H|GATAD2A_uc010xqw.1_Intron	NM_017660	NP_060130	Q86YP4	P66A_HUMAN	GATA zinc finger domain containing 2A	511					DNA methylation|negative regulation of transcription, DNA-dependent	nuclear speck|NuRD complex	protein binding, bridging|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TTGGCGTTCCGCTCAGGAGAG	0.667		NaN											0	0	0	0.012319	0	18	69									
ZNF536	9745	broad.mit.edu	37	19	30934886	30934886	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr19:30934886C>A	uc002nsu.1	+	2	555	c.417C>A	c.(415-417)TTC>TTA	p.F139L	ZNF536_uc010edd.1_Missense_Mutation_p.F139L	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	139	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding	p.F139F(1)		ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GCAAGCGCTTCCGCTTCAACA	0.637		NaN											1	0	4.87955e-14	0.005443	5.59802e-14	25	67									
TSHZ3	57616	broad.mit.edu	37	19	31769796	31769796	+	Silent	SNP	T	T	C	rs61747216	byFrequency	TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr19:31769796T>C	uc002nsy.3	-	2	968	c.903A>G	c.(901-903)CAA>CAG	p.Q301Q		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	301					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					GAGGCACTTTTTGGTAGTGTT	0.537		NaN											0	0	0	0.009718	0	44	96									
TTC9B	148014	broad.mit.edu	37	19	40722099	40722099	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr19:40722099C>T	uc002onc.2	-	3	709	c.691G>A	c.(691-693)GGG>AGG	p.G231R		NM_152479	NP_689692	Q8N6N2	TTC9B_HUMAN	tetratricopeptide repeat domain 9B	231							binding				0						GTCTGGGACCCAGCCCCACTG	0.597		NaN											0	0	0	0.003271	0	32	63									
ZNF574	64763	broad.mit.edu	37	19	42583136	42583136	+	Nonsense_Mutation	SNP	C	C	G			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr19:42583136C>G	uc002osm.3	+	2	547	c.378C>G	c.(376-378)TAC>TAG	p.Y126*	ZNF574_uc002osk.3_Nonsense_Mutation_p.Y216*	NM_022752	NP_073589	Q6ZN55	ZN574_HUMAN	zinc finger protein 574	126	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.059)				CCATCCACTACGAGTGTGTGG	0.632		NaN											0	0	0	0.00278	0	25	80									
IZUMO1	284359	broad.mit.edu	37	19	49248950	49248950	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr19:49248950C>A	uc002pkj.2	-	2	715	c.167G>T	c.(166-168)AGG>ATG	p.R56M	IZUMO1_uc010eme.2_RNA|IZUMO1_uc010emf.2_RNA	NM_182575	NP_872381	Q8IYV9	IZUM1_HUMAN	izumo sperm-egg fusion 1 precursor	56	Extracellular (Potential).				fusion of sperm to egg plasma membrane	integral to membrane				ovary(1)	1		all_lung(116;0.000156)|Lung NSC(112;0.000251)|all_epithelial(76;0.000761)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000348)|Epithelial(262;0.019)|GBM - Glioblastoma multiforme(486;0.022)		ATTCTCTACCCTTTCCATCAT	0.552		NaN											1	0	6.1244e-12	0.007835	6.94099e-12	41	106									
PNKP	11284	broad.mit.edu	37	19	50370414	50370414	+	Silent	SNP	A	A	G			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr19:50370414A>G	uc002pqh.2	-	1	100	c.48T>C	c.(46-48)CCT>CCC	p.P16P	PNKP_uc002pqg.2_5'Flank|PNKP_uc002pqi.2_5'UTR|PNKP_uc002pqj.2_Silent_p.P16P|PNKP_uc010enm.2_Silent_p.P16P|PNKP_uc002pqk.2_Silent_p.P16P	NM_007254	NP_009185	Q96T60	PNKP_HUMAN	polynucleotide kinase 3' phosphatase	16					DNA damage response, detection of DNA damage|DNA-dependent DNA replication|nucleotide-excision repair, DNA damage removal|response to oxidative stress|response to radiation	nucleolus	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|damaged DNA binding|double-stranded DNA binding|endonuclease activity|nucleotide kinase activity|polynucleotide 3'-phosphatase activity|protein binding			ovary(1)|kidney(1)	2		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0118)|OV - Ovarian serous cystadenocarcinoma(262;0.0134)		GCGCTCCCCCAGGGGGGCTCT	0.721		NaN						Other_BER_factors					0	0	0	0.001855	0	12	39									
SHANK1	50944	broad.mit.edu	37	19	51171701	51171701	+	Silent	SNP	G	G	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr19:51171701G>A	uc002psx.1	-	22	3535	c.3516C>T	c.(3514-3516)AGC>AGT	p.S1172S	SHANK1_uc002psw.1_Silent_p.S556S	NM_016148	NP_057232	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	1172					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			large_intestine(2)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		TGCTGCCCTGGCTGCTGCGGC	0.522		NaN											0	0	0	0.004007	0	11	15									
PXDN	7837	broad.mit.edu	37	2	1652948	1652948	+	Silent	SNP	C	C	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:1652948C>T	uc002qxa.2	-	17	2668	c.2604G>A	c.(2602-2604)CGG>CGA	p.R868R		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	868					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		CGCTCCTGGCCCGGGAGTCAT	0.662		NaN											0	0	0	0.010729	0	10	21									
TTC15	51112	broad.mit.edu	37	2	3425691	3425691	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:3425691C>T	uc002qxm.1	+	4	1410	c.1204C>T	c.(1204-1206)CGT>TGT	p.R402C	TTC15_uc002qxn.1_Missense_Mutation_p.R402C|TTC15_uc010ewm.1_Missense_Mutation_p.R402C	NM_016030	NP_057114	Q8WVT3	TTC15_HUMAN	tetratricopeptide repeat domain 15	402							binding			ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)	all_cancers(51;0.214)		OV - Ovarian serous cystadenocarcinoma(76;0.0402)|Epithelial(75;0.0986)|all cancers(51;0.149)		CCTGTGCGGACGTCTCCTCAC	0.587		NaN											0	0	0	0.006214	0	9	22									
C2orf86	51057	broad.mit.edu	37	2	63660991	63660991	+	Missense_Mutation	SNP	A	A	G			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:63660991A>G	uc002sch.2	-	9	1159	c.713T>C	c.(712-714)GTT>GCT	p.V238A	C2orf86_uc002sce.2_RNA|C2orf86_uc002scf.2_Missense_Mutation_p.V79A|C2orf86_uc010ypu.1_RNA|C2orf86_uc002scg.2_Missense_Mutation_p.V46A|C2orf86_uc002sci.1_Missense_Mutation_p.V214A|C2orf86_uc010fcr.1_Missense_Mutation_p.V128A	NM_015910	NP_056994	O95876	FRITZ_HUMAN	hypothetical protein LOC51057 isoform 2	238					cilium morphogenesis|regulation of embryonic cell shape|regulation of protein localization|septin cytoskeleton organization	cilium axoneme|cytoplasm|cytoskeleton|plasma membrane					0						CCAGCAAACAACTCTATCATG	0.433		NaN											0	0	0	0.008871	0	16	27									
DYSF	8291	broad.mit.edu	37	2	71894600	71894600	+	Silent	SNP	G	G	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:71894600G>A	uc002sie.2	+	47	5671	c.5295G>A	c.(5293-5295)GTG>GTA	p.V1765V	DYSF_uc010feg.2_Silent_p.V1796V|DYSF_uc010feh.2_Silent_p.V1772V|DYSF_uc002sig.3_Silent_p.V1751V|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Silent_p.V1786V|DYSF_uc010fef.2_Silent_p.V1803V|DYSF_uc010fei.2_Silent_p.V1782V|DYSF_uc010fek.2_Silent_p.V1783V|DYSF_uc010fej.2_Silent_p.V1773V|DYSF_uc010fel.2_Silent_p.V1752V|DYSF_uc010feo.2_Silent_p.V1797V|DYSF_uc010fem.2_Silent_p.V1787V|DYSF_uc010fen.2_Silent_p.V1804V|DYSF_uc002sif.2_Silent_p.V1766V|DYSF_uc010yqy.1_Silent_p.V646V|DYSF_uc010yqz.1_Silent_p.V526V	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	1765	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						CGGAGCACGTGGAGTCACGGC	0.652		NaN											0	0	0	0.007413	0	20	42									
CNGA3	1261	broad.mit.edu	37	2	98986521	98986521	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:98986521C>T	uc002syt.2	+	2	500	c.83C>T	c.(82-84)GCT>GTT	p.A28V	CNGA3_uc002syu.2_Missense_Mutation_p.A28V	NM_001298	NP_001289	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3 isoform	28					signal transduction|visual perception	integral to membrane	cGMP binding			ovary(5)|upper_aerodigestive_tract(1)	6						CTCAATCGCGCTGAAAATGGC	0.502		NaN											0	0	0	0.007413	0	19	27									
TBC1D8	11138	broad.mit.edu	37	2	101670703	101670703	+	Silent	SNP	G	G	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:101670703G>A	uc010fiv.2	-	4	584	c.453C>T	c.(451-453)TTC>TTT	p.F151F	TBC1D8_uc010yvw.1_Silent_p.F166F|TBC1D8_uc002tau.3_5'UTR	NM_001102426	NP_001095896	O95759	TBCD8_HUMAN	TBC1 domain family, member 8	151	GRAM 1.				blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			ovary(3)	3						CGGGGAAGTTGAACCTGGCCT	0.622		NaN											0	0	0	0.001984	0	7	12									
LRP1B	53353	broad.mit.edu	37	2	141812708	141812708	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:141812708C>A	uc002tvj.1	-	10	2501	c.1529G>T	c.(1528-1530)GGA>GTA	p.G510V	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	510	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GCCATCACTTCCCAAGTTGAA	0.433		NaN								TSP Lung(27;0.18)			1	0	1.58986e-06	0.008291	1.69888e-06	10	62									
TANC1	85461	broad.mit.edu	37	2	160074029	160074029	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:160074029G>A	uc002uag.2	+	20	3540	c.3266G>A	c.(3265-3267)AGA>AAA	p.R1089K	TANC1_uc010zcm.1_Missense_Mutation_p.R1081K|TANC1_uc010fom.1_Missense_Mutation_p.R895K|TANC1_uc010fon.2_5'UTR	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	1089	ANK 6.					cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						GCCGCAGGAAGAGGGAAGCTG	0.522		NaN											0	0	0	0.004289	0	35	202									
SCN1A	6323	broad.mit.edu	37	2	166870384	166870384	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:166870384C>A	uc010zcz.1	-	18	3560	c.3542G>T	c.(3541-3543)TGT>TTT	p.C1181F	SCN1A_uc002udo.3_Missense_Mutation_p.C1061F|SCN1A_uc010fpk.2_Missense_Mutation_p.C1033F	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1192						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	ATTGATTTGACAACACTTGAA	0.388		NaN											1	0	1.76847e-28	0.01441	2.09306e-28	70	100									
PDE11A	50940	broad.mit.edu	37	2	178545579	178545579	+	Missense_Mutation	SNP	T	T	G			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:178545579T>G	uc002ulq.2	-	16	2716	c.2398A>C	c.(2398-2400)ATC>CTC	p.I800L	PDE11A_uc002ulp.2_Missense_Mutation_p.I356L|PDE11A_uc002ulr.2_Missense_Mutation_p.I550L|PDE11A_uc002uls.1_Missense_Mutation_p.I442L|PDE11A_uc002ult.1_Missense_Mutation_p.I550L|PDE11A_uc002ulu.1_Missense_Mutation_p.I442L	NM_016953	NP_058649	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A isoform 4	800	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(3)|large_intestine(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			TGGTTTTTGATGTTCCAATCG	0.318		NaN							Primary_Pigmented_Nodular_Adrenocortical_Disease_Familial				0	0	0	0.004482	0	7	39									
TTN	7273	broad.mit.edu	37	2	179575634	179575634	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:179575634G>T	uc010zfg.1	-	95	24682	c.24458C>A	c.(24457-24459)CCC>CAC	p.P8153H	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.P4814H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	9080							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTCAAAGAAGGGTGGGTTCTT	0.483		NaN											1	0	0.00621372	0.006214	0.00634953	8	92									
TTN	7273	broad.mit.edu	37	2	179644785	179644785	+	Nonsense_Mutation	SNP	A	A	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:179644785A>T	uc010zfg.1	-	22	3895	c.3671T>A	c.(3670-3672)TTA>TAA	p.L1224*	TTN_uc010zfh.1_Nonsense_Mutation_p.L1178*|TTN_uc010zfi.1_Nonsense_Mutation_p.L1178*|TTN_uc010zfj.1_Nonsense_Mutation_p.L1178*|TTN_uc002unb.2_Nonsense_Mutation_p.L1224*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1224							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTCCTAATTAAGGCTTGTtc	0.308		NaN											0	0	0	0.003271	0	35	61									
TTN	7273	broad.mit.edu	37	2	179644787	179644787	+	Silent	SNP	G	G	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:179644787G>T	uc010zfg.1	-	22	3893	c.3669C>A	c.(3667-3669)GCC>GCA	p.A1223A	TTN_uc010zfh.1_Silent_p.A1177A|TTN_uc010zfi.1_Silent_p.A1177A|TTN_uc010zfj.1_Silent_p.A1177A|TTN_uc002unb.2_Silent_p.A1223A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1223							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCTAATTAAGGCTTGTtctt	0.313		NaN											1	0	1.56442e-22	0.012213	1.81706e-22	33	62									
ANKRD44	91526	broad.mit.edu	37	2	197889932	197889932	+	Silent	SNP	T	T	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:197889932T>A	uc002uua.1	-	17	1712	c.1635A>T	c.(1633-1635)CCA>CCT	p.P545P	ANKRD44_uc002utz.3_Silent_p.P277P	NM_153697	NP_710181	Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	570	ANK 17.						protein binding			ovary(4)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.246)			CTAAGTGGAGTGGACTCTTAG	0.383		NaN											0	0	0	0.009535	0	30	51									
SF3B1	23451	broad.mit.edu	37	2	198265453	198265453	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:198265453C>T	uc002uue.2	-	18	2752	c.2704G>A	c.(2704-2706)GAA>AAA	p.E902K		NM_012433	NP_036565	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1 isoform 1	902					nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			pancreas(3)|ovary(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.246)			GTAGTCTGTTCTTGGAAAGCA	0.318		NaN											0	0	0	0.003954	0	25	50									
MAP2	4133	broad.mit.edu	37	2	210559447	210559447	+	Silent	SNP	T	T	C			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:210559447T>C	uc002vde.1	+	7	2801	c.2553T>C	c.(2551-2553)ACT>ACC	p.T851T	MAP2_uc002vdc.1_Silent_p.T851T|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Silent_p.T847T	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	851					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	CCCCGGTAACTGATGAAAACC	0.493		NaN											0	0	0	0.001855	0	13	68									
SMARCAL1	50485	broad.mit.edu	37	2	217300080	217300080	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:217300080C>T	uc002vgc.3	+	9	1835	c.1505C>T	c.(1504-1506)CCA>CTA	p.P502L	SMARCAL1_uc010fvf.2_RNA|SMARCAL1_uc002vgd.3_Missense_Mutation_p.P502L|SMARCAL1_uc010fvg.2_Missense_Mutation_p.P502L	NM_014140	NP_054859	Q9NZC9	SMAL1_HUMAN	SWI/SNF-related matrix-associated	502	Helicase ATP-binding.				chromatin modification|DNA metabolic process|regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity			ovary(3)|breast(3)|skin(1)	7		Renal(323;0.0458)		Epithelial(149;9.48e-06)|all cancers(144;0.000621)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0111)		CGGTGGCTGCCATCTCTGAGC	0.547		NaN							Schimke_Immuno-Osseous_Dysplasia				0	0	0	0.003163	0	13	62									
TNS1	7145	broad.mit.edu	37	2	218713307	218713307	+	Missense_Mutation	SNP	A	A	G			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:218713307A>G	uc002vgt.2	-	17	1956	c.1558T>C	c.(1558-1560)TCT>CCT	p.S520P	TNS1_uc002vgr.2_Missense_Mutation_p.S520P|TNS1_uc002vgs.2_Missense_Mutation_p.S520P|TNS1_uc010zjv.1_Missense_Mutation_p.S520P|TNS1_uc010fvj.1_Missense_Mutation_p.S588P|TNS1_uc010fvk.1_Missense_Mutation_p.S645P|TNS1_uc010fvi.1_Missense_Mutation_p.S207P	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	520						cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		TCCAGAGAAGAGAGTGTGCCC	0.592		NaN											0	0	0	0.004007	0	14	62									
IHH	3549	broad.mit.edu	37	2	219924972	219924972	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:219924972C>T	uc002vjo.1	-	1	218	c.218G>A	c.(217-219)CGC>CAC	p.R73H	hsa-mir-3131|MI0014151_5'Flank	NM_002181	NP_002172	Q14623	IHH_HUMAN	Indian hedgehog homolog precursor	73					cell-cell signaling|intein-mediated protein splicing|proteolysis	extracellular space|plasma membrane	cholesterol binding|patched binding|peptidase activity			breast(1)	1		Renal(207;0.0915)		Epithelial(149;1.13e-06)|all cancers(144;0.000188)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CTCGGAGCTGCGAGCGATCTT	0.612		NaN											0	0	0	0.012213	0	32	54									
KIF1A	547	broad.mit.edu	37	2	241715279	241715279	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:241715279C>T	uc002vzy.2	-	11	1093	c.947G>A	c.(946-948)CGG>CAG	p.R316Q	KIF1A_uc010fzk.2_Missense_Mutation_p.R316Q|KIF1A_uc002vzz.1_Missense_Mutation_p.R316Q	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	316	Kinesin-motor.				anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		CAGGTTTTCCCGGAGGAGCCA	0.577		NaN											0	0	0	0.001168	0	6	24									
NEU4	129807	broad.mit.edu	37	2	242757712	242757712	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:242757712C>T	uc010fzr.2	+	4	879	c.793C>T	c.(793-795)CGC>TGC	p.R265C	NEU4_uc002wcl.2_RNA|NEU4_uc002wcm.2_Missense_Mutation_p.R265C|NEU4_uc002wcn.1_Missense_Mutation_p.R277C|NEU4_uc002wco.1_Missense_Mutation_p.R265C|NEU4_uc002wcp.1_Missense_Mutation_p.R277C	NM_080741	NP_542779	Q8WWR8	NEUR4_HUMAN	sialidase 4	265						lysosomal lumen|organelle inner membrane	exo-alpha-sialidase activity|protein binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;3.84e-33)|all cancers(36;8.08e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.41e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0825)		GCCCGCAGAGCGCGTGGCTTC	0.697		NaN											0	0	0	0.000602	0	4	3									
ZNF341	84905	broad.mit.edu	37	20	32349815	32349815	+	Silent	SNP	G	G	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr20:32349815G>A	uc002wzy.2	+	8	1196	c.1176G>A	c.(1174-1176)CAG>CAA	p.Q392Q	ZNF341_uc002wzx.2_Silent_p.Q385Q|ZNF341_uc010geq.2_Silent_p.Q302Q|ZNF341_uc010ger.2_RNA	NM_032819	NP_116208	Q9BYN7	ZN341_HUMAN	zinc finger protein 341	392					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						TGACCGTACAGGTCATGGCCC	0.567		NaN											0	0	0	0.007835	0	37	77									
CPNE1	8904	broad.mit.edu	37	20	34219095	34219095	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr20:34219095C>T	uc002xdf.2	-	12	1165	c.802G>A	c.(802-804)GTA>ATA	p.V268I	CPNE1_uc002xdc.2_5'UTR|CPNE1_uc010zvj.1_Missense_Mutation_p.V273I|CPNE1_uc002xde.2_Missense_Mutation_p.V244I|CPNE1_uc002xdg.2_Missense_Mutation_p.V268I|CPNE1_uc010gfi.2_RNA|CPNE1_uc010gfj.2_RNA|CPNE1_uc002xdh.2_Missense_Mutation_p.V268I|CPNE1_uc002xdi.2_Missense_Mutation_p.V268I|CPNE1_uc002xdj.2_Missense_Mutation_p.V268I|CPNE1_uc002xdk.2_Missense_Mutation_p.V268I|CPNE1_uc002xdl.2_Missense_Mutation_p.V268I|CPNE1_uc002xdm.2_Missense_Mutation_p.V268I|CPNE1_uc010gfk.1_Missense_Mutation_p.V268I	NM_152931	NP_690908	Q99829	CPNE1_HUMAN	copine I isoform a	268					lipid metabolic process|vesicle-mediated transport		calcium-dependent phospholipid binding|phosphatidylserine binding|transporter activity			upper_aerodigestive_tract(1)	1	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			TCTGTTTCTACCTGCAAATGA	0.493		NaN											0	0	0	0.01441	0	64	157									
KIAA0406	9675	broad.mit.edu	37	20	36611923	36611923	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr20:36611923C>T	uc002xhl.2	-	9	3414	c.3205G>A	c.(3205-3207)GGG>AGG	p.G1069R	KIAA0406_uc002xhm.2_Missense_Mutation_p.G1069R	NM_014657	NP_055472	O43156	TTI1_HUMAN	hypothetical protein LOC9675	1069							binding				0		Myeloproliferative disorder(115;0.00874)				CCGCTGGCCCCGTGCAGCTGC	0.652		NaN											0	0	0	0.001855	0	12	32									
CDH4	1002	broad.mit.edu	37	20	60508129	60508129	+	Missense_Mutation	SNP	G	G	A	rs142330895		TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr20:60508129G>A	uc002ybn.1	+	14	2340	c.2326G>A	c.(2326-2328)GTC>ATC	p.V776I	CDH4_uc002ybp.1_Missense_Mutation_p.V702I	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	776	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			CGAGGACGACGTCCGCGACAA	0.657		NaN											0	0	0	0.003954	0	21	56									
PWP2	5822	broad.mit.edu	37	21	45542227	45542227	+	Silent	SNP	G	G	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr21:45542227G>A	uc002zeb.2	+	14	1896	c.1806G>A	c.(1804-1806)GCG>GCA	p.A602A		NM_005049	NP_005040	Q15269	PWP2_HUMAN	PWP2 periodic tryptophan protein homolog	602						cytoplasm|nucleolus	signal transducer activity			pancreas(1)	1				STAD - Stomach adenocarcinoma(101;0.172)|Colorectal(79;0.2)		CCAAGCACGCGGCCAAGGGGA	0.582		NaN											0	0	0	0.006214	0	10	43									
ITGB2	3689	broad.mit.edu	37	21	46306766	46306766	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr21:46306766C>T	uc002zgd.2	-	14	2176	c.2132G>A	c.(2131-2133)GGC>GAC	p.G711D	ITGB2_uc002zge.2_Missense_Mutation_p.G711D|ITGB2_uc002zgf.3_Missense_Mutation_p.G711D|ITGB2_uc011afl.1_Missense_Mutation_p.G633D|ITGB2_uc010gpw.2_Missense_Mutation_p.G654D|ITGB2_uc002zgg.2_Missense_Mutation_p.G711D	NM_001127491	NP_001120963	P05107	ITB2_HUMAN	integrin, beta 2 precursor	711	Helical; (Potential).				apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			ovary(4)|central_nervous_system(3)|breast(2)	9				Colorectal(79;0.0669)	Simvastatin(DB00641)	CAGCACGATGCCTGCCACGGT	0.612		NaN											0	0	0	0.004482	0	7	57									
IL5RA	3568	broad.mit.edu	37	3	3139839	3139839	+	Missense_Mutation	SNP	T	T	G			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr3:3139839T>G	uc011ask.1	-	7	1147	c.503A>C	c.(502-504)CAG>CCG	p.Q168P	IL5RA_uc010hbq.2_Missense_Mutation_p.Q168P|IL5RA_uc010hbr.2_Intron|IL5RA_uc010hbs.2_Missense_Mutation_p.Q168P|IL5RA_uc011asl.1_Missense_Mutation_p.Q168P|IL5RA_uc011asm.1_Missense_Mutation_p.Q168P|IL5RA_uc010hbt.2_Missense_Mutation_p.Q168P|IL5RA_uc011asn.1_Missense_Mutation_p.Q168P|IL5RA_uc010hbu.2_Missense_Mutation_p.Q168P	NM_000564	NP_000555	Q01344	IL5RA_HUMAN	interleukin 5 receptor, alpha isoform 1	168	Extracellular (Potential).				cell proliferation	extracellular space|integral to membrane|plasma membrane	interleukin-5 receptor activity			ovary(1)	1				Epithelial(13;0.00278)|all cancers(10;0.00809)|OV - Ovarian serous cystadenocarcinoma(96;0.00944)		GAGAAAATACTGCGTGTCCTC	0.408		NaN											0	0	0	0.006122	0	17	76									
PRRT3	285368	broad.mit.edu	37	3	9989043	9989043	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr3:9989043G>C	uc003bul.2	-	4	1944	c.1814C>G	c.(1813-1815)TCG>TGG	p.S605W	CIDEC_uc003bto.2_Intron|PRRT3_uc003buk.2_RNA	NM_207351	NP_997234	Q5FWE3	PRRT3_HUMAN	proline-rich transmembrane protein 3 precursor	605	Helical; (Potential).					integral to membrane					0						CCAGGCGCACGACAAGCCCTG	0.711		NaN											0	0	0	0.000602	0	4	23									
ZNF385D	79750	broad.mit.edu	37	3	21465483	21465483	+	Missense_Mutation	SNP	T	T	G			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr3:21465483T>G	uc003cce.2	-	7	1334	c.926A>C	c.(925-927)AAA>ACA	p.K309T		NM_024697	NP_078973	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	309						nucleus	nucleic acid binding|zinc ion binding			large_intestine(2)|skin(2)|ovary(1)	5						CTTCTGTAGTTTGTTGTAAGG	0.423		NaN											0	0	0	0.00499	0	12	84									
LRRFIP2	9209	broad.mit.edu	37	3	37100399	37100399	+	Missense_Mutation	SNP	A	A	C			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr3:37100399A>C	uc003cgp.2	-	26	2175	c.1752T>G	c.(1750-1752)ATT>ATG	p.I584M	MLH1_uc011aye.1_Intron|LRRFIP2_uc011ayf.1_Missense_Mutation_p.I366M|LRRFIP2_uc003cgr.2_Missense_Mutation_p.I287M|LRRFIP2_uc003cgs.3_Missense_Mutation_p.I287M|LRRFIP2_uc003cgt.3_Missense_Mutation_p.I263M	NM_006309	NP_006300	Q9Y608	LRRF2_HUMAN	leucine rich repeat (in FLII) interacting	584	Potential.				Wnt receptor signaling pathway		LRR domain binding			ovary(1)	1						TCAGTTTTCTAATCTGAAATG	0.438		NaN											0	0	0	0.004482	0	9	59									
PLCD1	5333	broad.mit.edu	37	3	38050562	38050562	+	Missense_Mutation	SNP	A	A	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr3:38050562A>T	uc003chn.2	-	11	1818	c.1694T>A	c.(1693-1695)GTG>GAG	p.V565E	PLCD1_uc003chm.2_Missense_Mutation_p.V586E	NM_006225	NP_006216	P51178	PLCD1_HUMAN	phospholipase C, delta 1 isoform 2	565	PI-PLC Y-box.				intracellular signal transduction|lipid catabolic process|phospholipid metabolic process	cytoplasm	calcium ion binding|GTPase activating protein binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0519)|Kidney(284;0.0653)		CCACATCTCCACGGGGCTGTA	0.642		NaN											0	0	0	0.009096	0	4	29									
TRAK1	22906	broad.mit.edu	37	3	42244140	42244140	+	Missense_Mutation	SNP	T	T	C			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr3:42244140T>C	uc003cky.2	+	13	1856	c.1640T>C	c.(1639-1641)CTG>CCG	p.L547P	TRAK1_uc011azh.1_Missense_Mutation_p.L547P|TRAK1_uc011azi.1_Missense_Mutation_p.L547P|TRAK1_uc003ckz.3_Missense_Mutation_p.L473P|TRAK1_uc011azj.1_Missense_Mutation_p.L473P|TRAK1_uc003cla.2_Missense_Mutation_p.L489P	NM_001042646	NP_001036111	Q9UPV9	TRAK1_HUMAN	OGT(O-Glc-NAc transferase)-interacting protein	547					endosome to lysosome transport|protein O-linked glycosylation|protein targeting|regulation of transcription from RNA polymerase II promoter	early endosome|mitochondrion|nucleus				ovary(1)	1						ATCATGTCCCTGGGCACGCAC	0.622		NaN											0	0	0	0.014323	0	22	54									
MST1R	4486	broad.mit.edu	37	3	49932949	49932949	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr3:49932949G>T	uc003cxy.3	-	13	3259	c.2995C>A	c.(2995-2997)CTG>ATG	p.L999M	MST1R_uc011bdc.1_Translation_Start_Site	NM_002447	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor precursor	999	Cytoplasmic (Potential).				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			ovary(5)|lung(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		GTCTGGTCCAGGGATGCCAGG	0.567		NaN											1	0	1.75199e-13	0.007291	1.99769e-13	29	57									
TLR9	54106	broad.mit.edu	37	3	52256636	52256636	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr3:52256636G>A	uc003dda.1	-	2	2330	c.1696C>T	c.(1696-1698)CAC>TAC	p.H566Y	TLR9_uc003ddb.2_Missense_Mutation_p.H663Y	NM_017442	NP_059138	Q9NR96	TLR9_HUMAN	toll-like receptor 9 isoform A precursor	566	LRR 18.|Extracellular (Potential).				defense response to bacterium|fibroblast growth factor receptor signaling pathway|I-kappaB phosphorylation|inflammatory response|innate immune response|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|response to molecule of bacterial origin	apical plasma membrane|basolateral plasma membrane|early phagosome|endoplasmic reticulum membrane|endosome membrane|extracellular region|integral to membrane|lysosome	interleukin-1 receptor binding|siRNA binding|transmembrane receptor activity			large_intestine(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;2.41e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Chloroquine(DB00608)	CTGAAGTTGTGGCCCACGCCC	0.627		NaN											0	0	0	0.00245	0	14	38									
CNTN3	5067	broad.mit.edu	37	3	74414794	74414794	+	Missense_Mutation	SNP	A	A	G			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr3:74414794A>G	uc003dpm.1	-	8	1086	c.1006T>C	c.(1006-1008)TAT>CAT	p.Y336H		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	336	Ig-like C2-type 4.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		CATTCCCAATAAAGACTGTCC	0.448		NaN											0	0	0	0.01441	0	91	201									
IFT57	55081	broad.mit.edu	37	3	107881334	107881334	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr3:107881334C>G	uc003dwx.3	-	11	1528	c.1280G>C	c.(1279-1281)GGC>GCC	p.G427A		NM_018010	NP_060480	Q9NWB7	IFT57_HUMAN	estrogen-related receptor beta like 1	427					activation of caspase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cilium|microtubule basal body	DNA binding|protein binding			ovary(1)|skin(1)|pancreas(1)	3			OV - Ovarian serous cystadenocarcinoma(3;0.0428)|Epithelial(53;0.246)			TTAATAAAAGCCTGTTGCTGG	0.343		NaN											0	0	0	0.01441	0	46	57									
PODXL2	50512	broad.mit.edu	37	3	127379999	127379999	+	Silent	SNP	G	G	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr3:127379999G>A	uc003ejq.2	+	3	1152	c.1128G>A	c.(1126-1128)ACG>ACA	p.T376T		NM_015720	NP_056535	Q9NZ53	PDXL2_HUMAN	podocalyxin-like 2 precursor	376	Extracellular (Potential).				leukocyte tethering or rolling	integral to plasma membrane	glycosaminoglycan binding|protein binding			ovary(1)|central_nervous_system(1)	2						GGGATTCTACGCAGGTAAAGT	0.582		NaN											0	0	0	0.010729	0	12	44									
PIK3CB	5291	broad.mit.edu	37	3	138474750	138474750	+	Silent	SNP	T	T	C			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr3:138474750T>C	uc011bmq.1	-	2	243	c.243A>G	c.(241-243)GCA>GCG	p.A81A		NM_006219	NP_006210	P42338	PK3CB_HUMAN	catalytic phosphatidylinositol 3-kinase beta	81	PI3K-ABD.				activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						GATTCACACATGCAAACATAT	0.368		NaN											0	0	0	0.010504	0	21	99									
IGSF10	285313	broad.mit.edu	37	3	151161553	151161553	+	Missense_Mutation	SNP	G	G	C	rs143471166		TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr3:151161553G>C	uc011bod.1	-	5	5182	c.5182C>G	c.(5182-5184)CTG>GTG	p.L1728V	IGSF10_uc011bob.1_5'Flank|IGSF10_uc011boc.1_5'Flank	NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	1728	Ig-like C2-type 3.				cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GTGCCAAACAGATTGGATGCG	0.517		NaN											0	0	0	0.007835	0	41	47									
DHX36	170506	broad.mit.edu	37	3	154018863	154018863	+	Missense_Mutation	SNP	T	T	C			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr3:154018863T>C	uc003ezy.3	-	10	1352	c.1271A>G	c.(1270-1272)CAA>CGA	p.Q424R	DHX36_uc010hvq.2_Missense_Mutation_p.Q424R|DHX36_uc003ezz.3_Missense_Mutation_p.Q424R	NM_020865	NP_065916	Q9H2U1	DHX36_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 36	424						cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			TACATGCCCTTGCATGAAACC	0.328		NaN											0	0	0	0.01441	0	60	83									
TP63	8626	broad.mit.edu	37	3	189349307	189349307	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr3:189349307G>A	uc003fry.2	+	1	92	c.3G>A	c.(1-3)ATG>ATA	p.M1I	TP63_uc003frx.2_Missense_Mutation_p.M1I|TP63_uc003frz.2_Missense_Mutation_p.M1I|TP63_uc010hzc.1_Missense_Mutation_p.M1I	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	1	Transcription activation.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		TGAAGGAAATGAATTTTGAAA	0.373		NaN							Hay-Wells_syndrome	HNSCC(45;0.13)			0	0	0	0.01441	0	61	127									
SLC34A2	10568	broad.mit.edu	37	4	25677925	25677925	+	Missense_Mutation	SNP	A	A	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr4:25677925A>T	uc003grr.2	+	13	1708	c.1627A>T	c.(1627-1629)ACG>TCG	p.T543S	SLC34A2_uc003grs.2_Missense_Mutation_p.T542S|SLC34A2_uc010iev.2_Missense_Mutation_p.T542S	NM_006424	NP_006415	O95436	NPT2B_HUMAN	solute carrier family 34 (sodium phosphate),	543	Helical; Name=M7; (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			skin(3)|ovary(1)|kidney(1)	5		Breast(46;0.0503)				GATCCCGCTGACGGTGTTTGG	0.607		NaN											0	0	0	0.01441	0	48	73									
TMPRSS11B	132724	broad.mit.edu	37	4	69101967	69101967	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr4:69101967G>T	uc003hdw.3	-	3	278	c.142C>A	c.(142-144)CAA>AAA	p.Q48K		NM_182502	NP_872308	Q86T26	TM11B_HUMAN	transmembrane protease, serine 11B	48	SEA.|Extracellular (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						AAATCACCTTGATAATAGTAA	0.328		NaN											1	0	2.56e-06	0.009096	2.68944e-06	3	18									
ANK2	287	broad.mit.edu	37	4	114170923	114170923	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr4:114170923G>A	uc003ibe.3	+	10	995	c.895G>A	c.(895-897)GGG>AGG	p.G299R	ANK2_uc003ibd.3_Missense_Mutation_p.G278R|ANK2_uc003ibf.3_Missense_Mutation_p.G299R|ANK2_uc003ibc.2_Missense_Mutation_p.G275R|ANK2_uc011cgb.1_Missense_Mutation_p.G314R	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	299	ANK 9.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TTGGCAGGATGGGTTGACACC	0.458		NaN											0	0	0	0.001168	0	5	22									
FGA	2243	broad.mit.edu	37	4	155508016	155508016	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr4:155508016C>A	uc003iod.1	-	5	623	c.565G>T	c.(565-567)GCT>TCT	p.A189S	FGA_uc003ioe.1_Missense_Mutation_p.A189S|FGA_uc003iof.1_Intron	NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	189	By similarity.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	ACTTCACGAGCTAAAGCCCTA	0.418		NaN											1	0	0.00198382	0.001984	0.00203832	6	75									
GUCY1A3	2982	broad.mit.edu	37	4	156631990	156631990	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr4:156631990G>A	uc003iov.2	+	7	1209	c.673G>A	c.(673-675)GTA>ATA	p.V225I	GUCY1A3_uc003iou.2_Missense_Mutation_p.V225I|GUCY1A3_uc010iqc.2_Missense_Mutation_p.V225I|GUCY1A3_uc003iow.2_Missense_Mutation_p.V225I|GUCY1A3_uc010iqd.2_Missense_Mutation_p.V224I|GUCY1A3_uc003iox.2_Missense_Mutation_p.V225I|GUCY1A3_uc003ioz.2_5'UTR|GUCY1A3_uc003ioy.2_Missense_Mutation_p.V225I|GUCY1A3_uc010iqe.2_5'UTR|GUCY1A3_uc003ipa.2_Intron|GUCY1A3_uc003ipb.2_Missense_Mutation_p.V225I	NM_000856	NP_000847	Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3 isoform A	225					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		AGCTGCTCACGTATTATATGA	0.448		NaN											0	0	0	0.00632	0	29	74									
HMGB2	3148	broad.mit.edu	37	4	174253977	174253977	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr4:174253977C>T	uc011ckc.1	-	3	586	c.466G>A	c.(466-468)GAA>AAA	p.E156K	HMGB2_uc003ita.3_Missense_Mutation_p.E156K|HMGB2_uc003itb.2_Missense_Mutation_p.E156K|HMGB2_uc003itc.2_3'UTR	NM_001130689	NP_001124161	P26583	HMGB2_HUMAN	high-mobility group box 2	156	HMG box 2.				base-excision repair, DNA ligation|cell chemotaxis|cellular response to lipopolysaccharide|DNA fragmentation involved in apoptotic nuclear change|DNA topological change|negative regulation of transcription, DNA-dependent|nucleosome assembly|phosphatidylinositol-mediated signaling|positive regulation of DNA binding|positive regulation of endothelial cell proliferation|positive regulation of erythrocyte differentiation|positive regulation of megakaryocyte differentiation|positive regulation of nuclease activity|positive regulation of transcription from RNA polymerase II promoter|V(D)J recombination	condensed chromosome|extracellular space|nucleolus|nucleoplasm|perinuclear region of cytoplasm|protein complex	chemoattractant activity|damaged DNA binding|DNA bending activity|double-stranded DNA binding|RAGE receptor binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding|transcription regulatory region DNA binding				0		Prostate(90;0.0132)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_hematologic(60;0.107)|all_neural(102;0.122)		all cancers(43;9.58e-18)|Epithelial(43;3.75e-16)|OV - Ovarian serous cystadenocarcinoma(60;6.24e-09)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		TGTACCTTTTCATATTTCTCC	0.363		NaN											0	0	0	0.01441	0	85	116									
NPR3	4883	broad.mit.edu	37	5	32780872	32780872	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr5:32780872G>A	uc003jhv.2	+	5	1458	c.1240G>A	c.(1240-1242)GGG>AGG	p.G414R	NPR3_uc010iuo.2_Missense_Mutation_p.G198R|NPR3_uc011cnz.1_Missense_Mutation_p.G198R|NPR3_uc003jhu.2_Missense_Mutation_p.G414R	NM_000908	NP_000899	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase	414	Extracellular (Potential).				osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			ovary(1)|central_nervous_system(1)	2					Nesiritide(DB04899)	AGACCGATATGGGGATTTCTC	0.547		NaN											0	0	0	0.01441	0	70	148									
BDP1	55814	broad.mit.edu	37	5	70761989	70761989	+	Silent	SNP	A	A	G			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr5:70761989A>G	uc003kbp.1	+	5	989	c.726A>G	c.(724-726)CCA>CCG	p.P242P	BDP1_uc003kbn.1_Silent_p.P242P|BDP1_uc003kbo.2_Silent_p.P242P	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	242	Interaction with ZBTB43.				regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		ATGATGGGCCATTACTGGTTC	0.368		NaN											0	0	0	0.009718	0	41	53									
ZNF608	57507	broad.mit.edu	37	5	123983756	123983756	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr5:123983756G>C	uc003ktq.1	-	4	2444	c.2321C>G	c.(2320-2322)ACT>AGT	p.T774S	ZNF608_uc003ktr.1_Intron|ZNF608_uc003kts.1_Missense_Mutation_p.T774S|ZNF608_uc003ktt.1_Missense_Mutation_p.T774S	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	774						intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		CTGAACAACAGTTGTTGTGAG	0.552		NaN											0	0	0	0.000602	0	5	81									
GRM6	2916	broad.mit.edu	37	5	178416401	178416401	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr5:178416401C>T	uc003mjr.2	-	5	1197	c.1018G>A	c.(1018-1020)GAC>AAC	p.D340N	GRM6_uc010jla.1_5'UTR|GRM6_uc003mjs.1_5'UTR	NM_000843	NP_000834	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6 precursor	340	Extracellular (Potential).				detection of visible light|visual perception	integral to plasma membrane				lung(4)|ovary(2)|breast(1)|pancreas(1)	8	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		AAGTACTGGTCAAATCCTACA	0.527		NaN											0	0	0	0.013537	0	13	68									
GRM6	2916	broad.mit.edu	37	5	178416406	178416406	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr5:178416406C>T	uc003mjr.2	-	5	1192	c.1013G>A	c.(1012-1014)GGA>GAA	p.G338E	GRM6_uc010jla.1_5'UTR|GRM6_uc003mjs.1_5'UTR	NM_000843	NP_000834	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6 precursor	338	Extracellular (Potential).				detection of visible light|visual perception	integral to plasma membrane				lung(4)|ovary(2)|breast(1)|pancreas(1)	8	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		CTGGTCAAATCCTACAGACAG	0.532		NaN											0	0	0	0.008291	0	11	66									
TFAP2A	7020	broad.mit.edu	37	6	10410399	10410399	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr6:10410399G>A	uc003myr.2	-	2	467	c.215C>T	c.(214-216)CCT>CTT	p.P72L	TFAP2A_uc003myq.2_Missense_Mutation_p.P66L|TFAP2A_uc003mys.2_Intron|TFAP2A_uc011dih.1_Missense_Mutation_p.P72L|TFAP2A_uc003myt.2_Missense_Mutation_p.P68L|TFAP2A_uc003myu.1_Missense_Mutation_p.P72L|TFAP2A_uc003myv.1_Missense_Mutation_p.P58L|TFAP2A_uc011dii.1_Missense_Mutation_p.P68L|uc003myw.2_5'Flank	NM_003220	NP_003211	P05549	AP2A_HUMAN	transcription factor AP-2 alpha isoform a	72	Gln/Pro-rich (transactivation domain).				ectoderm development|positive regulation of bone mineralization|positive regulation of tooth mineralization|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	centrosome|Golgi apparatus|nucleus	chromatin binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding	p.P66R(1)		ovary(1)	1	Breast(50;0.0427)|Ovarian(93;0.0991)	all_hematologic(90;0.107)				GTGGGAGTAAGGATCTTGCGA	0.672		NaN											0	0	0	0.004482	0	8	63									
OR2W1	26692	broad.mit.edu	37	6	29012935	29012935	+	Silent	SNP	A	A	G			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr6:29012935A>G	uc003nlw.2	-	1	18	c.18T>C	c.(16-18)TAT>TAC	p.Y6Y		NM_030903	NP_112165	Q9Y3N9	OR2W1_HUMAN	olfactory receptor, family 2, subfamily W,	6	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						GTAAAGAACTATAATTGCTTT	0.284		NaN											0	0	0	0.00632	0	28	51									
CCHCR1	54535	broad.mit.edu	37	6	31110378	31110378	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr6:31110378C>T	uc003nsr.3	-	18	2463	c.2340G>A	c.(2338-2340)ATG>ATA	p.M780I	CCHCR1_uc011dne.1_Missense_Mutation_p.M766I|CCHCR1_uc003nsq.3_Missense_Mutation_p.M833I|CCHCR1_uc003nsp.3_Missense_Mutation_p.M869I	NM_019052	NP_061925	Q8TD31	CCHCR_HUMAN	coiled-coil alpha-helical rod protein 1 isoform	780					cell differentiation|multicellular organismal development	cytoplasm|nucleus	protein binding			skin(1)	1						CTTAGCTGCTCATCTGGGGAT	0.577		NaN											0	0	0	0.004007	0	17	36									
PGC	5225	broad.mit.edu	37	6	41712175	41712175	+	Silent	SNP	G	G	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr6:41712175G>A	uc003ora.1	-	3	337	c.288C>T	c.(286-288)AAC>AAT	p.N96N		NM_002630	NP_002621	P20142	PEPC_HUMAN	progastricsin (pepsinogen C) precursor	96					digestion|proteolysis	extracellular space	aspartic-type endopeptidase activity				0	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;0.000132)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			GCACCCACAAGTTGGAGGAGC	0.612		NaN											0	0	0	0.014323	0	21	50									
TRERF1	55809	broad.mit.edu	37	6	42203985	42203985	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr6:42203985C>A	uc003osd.2	-	16	3587	c.3024G>T	c.(3022-3024)CAG>CAT	p.Q1008H	TRERF1_uc011duq.1_Missense_Mutation_p.Q925H|TRERF1_uc003osb.2_Missense_Mutation_p.Q764H|TRERF1_uc003osc.2_Missense_Mutation_p.Q764H|TRERF1_uc003ose.2_Missense_Mutation_p.Q1028H	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	1008	Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			AGCCTGAGGGCTGGCCCAGGG	0.627		NaN											1	0	2.0095e-06	0.001984	2.13509e-06	6	14									
DPPA5	340168	broad.mit.edu	37	6	74063929	74063929	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr6:74063929C>T	uc003pgs.1	-	1	25	c.20G>A	c.(19-21)CGT>CAT	p.R7H		NM_001025290	NP_001020461	A6NC42	DPPA5_HUMAN	developmental pluripotency associated 5	7					multicellular organismal development	cytoplasm	RNA binding				0						GATATGTCTACGTGCCGGGAG	0.572		NaN											0	0	0	0.009096	0	4	29									
TPBG	7162	broad.mit.edu	37	6	83075858	83075858	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr6:83075858G>T	uc003pjn.3	+	3	2116	c.1180G>T	c.(1180-1182)GAT>TAT	p.D394Y	TPBG_uc010kbj.2_Missense_Mutation_p.D394Y|TPBG_uc003pjo.2_Missense_Mutation_p.D394Y	NM_006670	NP_006661	Q13641	TPBG_HUMAN	trophoblast glycoprotein precursor	394	Cytoplasmic (Potential).				cell adhesion	integral to plasma membrane				central_nervous_system(1)	1		all_cancers(76;0.000805)|Acute lymphoblastic leukemia(125;3.85e-06)|all_hematologic(105;0.0017)|all_epithelial(107;0.0897)		BRCA - Breast invasive adenocarcinoma(397;0.107)		TGCCTGCAGGGATCACATGGA	0.423		NaN											1	0	1.50039e-11	0.012319	1.68008e-11	19	63									
C6orf97	80129	broad.mit.edu	37	6	151907137	151907137	+	Silent	SNP	G	G	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr6:151907137G>A	uc003qol.2	+	7	1295	c.1206G>A	c.(1204-1206)GAG>GAA	p.E402E		NM_025059	NP_079335	Q8IYT3	CF097_HUMAN	hypothetical protein LOC80129	402	Potential.										0		Ovarian(120;0.126)	BRCA - Breast invasive adenocarcinoma(37;0.111)	OV - Ovarian serous cystadenocarcinoma(155;1.48e-10)		ATATGTTGGAGACTCTTCAGG	0.473		NaN											0	0	0	0.000602	0	4	13									
ETV1	2115	broad.mit.edu	37	7	13971355	13971355	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr7:13971355C>G	uc011jxq.1	-	9	1313	c.574G>C	c.(574-576)GAA>CAA	p.E192Q	ETV1_uc011jxn.1_Missense_Mutation_p.E152Q|ETV1_uc011jxo.1_Missense_Mutation_p.E89Q|ETV1_uc011jxp.1_Missense_Mutation_p.E134Q|ETV1_uc003ssw.3_Missense_Mutation_p.E192Q|ETV1_uc003ssx.2_RNA|ETV1_uc011jxr.1_Missense_Mutation_p.E174Q|ETV1_uc011jxs.1_Missense_Mutation_p.E174Q|ETV1_uc010ktv.2_Missense_Mutation_p.E61Q	NM_004956	NP_004947	P50549	ETV1_HUMAN	ets variant gene 1 isoform a	192					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		TMPRSS2/ETV1(24)|EWSR1/ETV1(7)	prostate(24)|soft_tissue(4)|bone(3)|lung(2)|central_nervous_system(1)|ovary(1)	35						TTACAGGGTTCAGAAAGCTGG	0.468		NaN	T	EWSR1|TMPRSS2|SLC45A3|C15orf21|HNRNPA2B1. ACSL3	Ewing sarcoma|prostate								0	0	0	0.004482	0	6	34									
EVX1	2128	broad.mit.edu	37	7	27282715	27282715	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr7:27282715G>C	uc003szd.1	+	1	552	c.66G>C	c.(64-66)AAG>AAC	p.K22N	EVX1_uc011jzn.1_5'UTR|EVX1_uc010kuy.1_Missense_Mutation_p.K22N	NM_001989	NP_001980	P49640	EVX1_HUMAN	even-skipped homeobox 1	22						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1						TGGTTGGCAAGAGAGTCTCAA	0.652		NaN											0	0	0	0.001168	0	4	8									
CCDC129	223075	broad.mit.edu	37	7	31683174	31683174	+	Silent	SNP	C	C	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr7:31683174C>T	uc003tcj.1	+	11	3183	c.2190C>T	c.(2188-2190)CCC>CCT	p.P730P	CCDC129_uc011kad.1_Silent_p.P740P|CCDC129_uc003tci.1_Silent_p.P581P|CCDC129_uc011kae.1_Silent_p.P756P|CCDC129_uc003tck.1_Silent_p.P638P	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	730											0						GGACTGGTCCCAGAGGAACAT	0.507		NaN											0	0	0	0.004007	0	16	50									
TXNDC3	51314	broad.mit.edu	37	7	37904018	37904018	+	Missense_Mutation	SNP	A	A	G			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr7:37904018A>G	uc003tfn.2	+	9	895	c.523A>G	c.(523-525)AGA>GGA	p.R175G		NM_016616	NP_057700	Q8N427	TXND3_HUMAN	thioredoxin domain containing 3	175	NDK 1.				cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3						AGAAATTAAAAGAAAAGTAAG	0.274		NaN							Kartagener_syndrome				0	0	0	0.004672	0	3	12									
ZMIZ2	83637	broad.mit.edu	37	7	44795867	44795867	+	Missense_Mutation	SNP	A	A	G			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr7:44795867A>G	uc003tlr.2	+	2	142	c.19A>G	c.(19-21)ATG>GTG	p.M7V	ZMIZ2_uc003tlq.2_Missense_Mutation_p.M7V|ZMIZ2_uc003tls.2_Missense_Mutation_p.M7V	NM_031449	NP_113637	Q8NF64	ZMIZ2_HUMAN	zinc finger, MIZ-type containing 2 isoform 1	7					positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding			ovary(2)|large_intestine(2)|breast(1)	5						CATGAACCCCATGAAACCTGC	0.607		NaN											0	0	0	0.008871	0	19	35									
ADCY1	107	broad.mit.edu	37	7	45726145	45726145	+	Splice_Site	SNP	G	G	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr7:45726145G>A	uc003tne.3	+	14	2346	c.2328_splice	c.e14-1	p.G776_splice		NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1						activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	TCTTCCCCCAGGGGTGGTGCC	0.612		NaN											0	0	0	0.001855	0	12	30									
ZNF804B	219578	broad.mit.edu	37	7	88963715	88963715	+	Silent	SNP	T	T	C			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr7:88963715T>C	uc011khi.1	+	4	1957	c.1419T>C	c.(1417-1419)TAT>TAC	p.Y473Y		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	473						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			GTATCTCTTATGGCTGCAACC	0.433		NaN								HNSCC(36;0.09)			0	0	0	0.003954	0	25	59									
CSMD1	64478	broad.mit.edu	37	8	2824091	2824091	+	Splice_Site	SNP	C	C	G			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr8:2824091C>G	uc011kwk.1	-	58	9493	c.9103_splice	c.e58+1	p.I3035_splice	CSMD1_uc011kwj.1_Splice_Site_p.I2364_splice|CSMD1_uc010lrg.2_Intron	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor							integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGCTTACTAACTTGTGCAGTC	0.443		NaN											0	0	0	0.000602	0	5	12									
ZFHX4	79776	broad.mit.edu	37	8	77767234	77767234	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr8:77767234C>T	uc003yav.2	+	10	8329	c.7942C>T	c.(7942-7944)CAC>TAC	p.H2648Y	ZFHX4_uc003yau.1_Missense_Mutation_p.H2693Y|ZFHX4_uc003yaw.1_Missense_Mutation_p.H2648Y	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2648	C2H2-type 17.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CTTAGAAAGCCACATTCGCTC	0.542		NaN								HNSCC(33;0.089)			0	0	0	0.008291	0	9	53									
TRHR	7201	broad.mit.edu	37	8	110131363	110131363	+	Silent	SNP	C	C	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr8:110131363C>T	uc003ymz.3	+	2	892	c.876C>T	c.(874-876)CTC>CTT	p.L292L		NM_003301	NP_003292	P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	292	Extracellular (Potential).					integral to plasma membrane	thyrotropin-releasing hormone receptor activity			skin(2)|lung(1)	3			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			ACTCATTTCTCTCCAGTCCTT	0.428		NaN											0	0	0	0.01441	0	118	206									
PKHD1L1	93035	broad.mit.edu	37	8	110439238	110439238	+	Silent	SNP	C	C	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr8:110439238C>T	uc003yne.2	+	25	2957	c.2853C>T	c.(2851-2853)CCC>CCT	p.P951P		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	951	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CAGGCCTCCCCGCTGCTGTGT	0.438		NaN								HNSCC(38;0.096)			0	0	0	0.004007	0	17	85									
NOV	4856	broad.mit.edu	37	8	120428805	120428805	+	Silent	SNP	C	C	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr8:120428805C>T	uc003yoq.2	+	1	254	c.33C>T	c.(31-33)CTC>CTT	p.L11L		NM_002514	NP_002505	P48745	NOV_HUMAN	nephroblastoma overexpressed precursor	11					regulation of cell growth		growth factor activity|insulin-like growth factor binding			ovary(2)|skin(2)|kidney(1)	5	all_cancers(13;3.84e-26)|Lung NSC(37;1.19e-08)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.000507)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GCTTTTGTCTCCGAAAGCAGT	0.542		NaN									OREG0018940	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001984	0	6	13									
FER1L6	654463	broad.mit.edu	37	8	125072849	125072849	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr8:125072849C>G	uc003yqw.2	+	24	3252	c.3046C>G	c.(3046-3048)CAG>GAG	p.Q1016E	uc003yqy.1_RNA	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	1016	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GGATCGGCCTCAGGCTCTCAT	0.542		NaN											0	0	0	0.00333	0	25	39									
DOCK8	81704	broad.mit.edu	37	9	429743	429743	+	Silent	SNP	C	C	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr9:429743C>T	uc003zgf.2	+	36	4627	c.4515C>T	c.(4513-4515)TTC>TTT	p.F1505F	DOCK8_uc010mgu.2_Silent_p.F807F|DOCK8_uc010mgv.2_Silent_p.F1405F|DOCK8_uc003zgk.2_Silent_p.F963F	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1505	DHR-2.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		AACAGTGTTTCGACCTATGTC	0.502		NaN											0	0	0	0.01441	0	60	18									
RLN1	6013	broad.mit.edu	37	9	5339616	5339616	+	Missense_Mutation	SNP	A	A	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr9:5339616A>T	uc003zjb.1	-	1	258	c.131T>A	c.(130-132)ATT>AAT	p.I44N		NM_006911	NP_008842	P04808	REL1_HUMAN	relaxin 1 preproprotein	44					female pregnancy|signal transduction	extracellular region	hormone activity				0	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.02)|Lung(218;0.0984)		GCAAATGGCAATCTGCGCGCG	0.527		NaN											0	0	0	0.009096	0	4	56									
MPDZ	8777	broad.mit.edu	37	9	13205963	13205963	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr9:13205963C>A	uc010mia.1	-	10	1483	c.1426G>T	c.(1426-1428)GTC>TTC	p.V476F	MPDZ_uc010mhy.2_Missense_Mutation_p.V476F|MPDZ_uc010mhz.2_Missense_Mutation_p.V476F|MPDZ_uc011lmn.1_Missense_Mutation_p.V476F|MPDZ_uc003zlb.3_Missense_Mutation_p.V476F	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	476					interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		TCTTTTGTGACGTCTTCCCTT	0.418		NaN											1	0	2.56e-06	0.009096	2.68944e-06	4	39									
ARID3C	138715	broad.mit.edu	37	9	34622477	34622477	+	Silent	SNP	T	T	C			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr9:34622477T>C	uc011lon.1	-	5	915	c.915A>G	c.(913-915)GCA>GCG	p.A305A	DCTN3_uc003zuw.1_5'Flank|DCTN3_uc003zux.1_5'Flank	NM_001017363	NP_001017363	A6NKF2	ARI3C_HUMAN	AT rich interactive domain 3C (BRIGHT- like)	305	REKLES.|Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	all_epithelial(49;0.102)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.175)		TAGGTCCCAGTGCCAGGCCCA	0.582		NaN											0	0	0	0.010771	0	44	34									
HRCT1	646962	broad.mit.edu	37	9	35906559	35906559	+	Missense_Mutation	SNP	A	A	C			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr9:35906559A>C	uc003zyr.1	+	1	371	c.275A>C	c.(274-276)CAC>CCC	p.H92P	LOC158376_uc003zys.1_5'Flank	NM_001039792	NP_001034881	Q6UXD1	HRCT1_HUMAN	histidine rich carboxyl terminus 1	92	His-rich.					integral to membrane					0						caccaccaccacccccgccac	0.393		NaN											0	0	0	0.013537	0	7	8									
DFNB31	25861	broad.mit.edu	37	9	117186682	117186682	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr9:117186682G>C	uc004biz.3	-	6	1997	c.1348C>G	c.(1348-1350)CGT>GGT	p.R450G	DFNB31_uc004bix.2_Missense_Mutation_p.R99G|DFNB31_uc004biy.3_Missense_Mutation_p.R67G|DFNB31_uc004bja.3_Missense_Mutation_p.R450G	NM_015404	NP_056219	Q9P202	WHRN_HUMAN	CASK-interacting protein CIP98 isoform 1	450					inner ear receptor stereocilium organization|retina homeostasis|sensory perception of light stimulus|sensory perception of sound	cytoplasm|growth cone|stereocilium				ovary(4)|central_nervous_system(1)|pancreas(1)	6						CTGCCACCACGGTACTCATCC	0.632		NaN											0	0	0	0.010729	0	12	56									
TSC1	7248	broad.mit.edu	37	9	135777087	135777087	+	Splice_Site	SNP	C	C	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr9:135777087C>A	uc004cca.2	-	19	2626	c.2392_splice	c.e19-1	p.T798_splice	TSC1_uc004ccb.3_Splice_Site_p.T797_splice|TSC1_uc011mcq.1_Splice_Site_p.T747_splice|TSC1_uc011mcr.1_Intron	NM_000368	NP_000359	Q92574	TSC1_HUMAN	tuberous sclerosis 1 protein isoform 1						activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding	p.?(1)		lung(4)|central_nervous_system(3)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|urinary_tract(1)|skin(1)|ovary(1)|bone(1)	14				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		CCAGCTTCGTCTGCCCAAAGA	0.547		NaN	D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis		OREG0019577	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	7.73544e-29	0.01441	9.21355e-29	68	42									
SNAPC4	6621	broad.mit.edu	37	9	139276292	139276292	+	Silent	SNP	G	G	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr9:139276292G>A	uc004chh.2	-	17	2310	c.2301C>T	c.(2299-2301)GCC>GCT	p.A767A		NM_003086	NP_003077	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex,	767					snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		TCTGCACTACGGCGGGTCTCT	0.642		NaN											0	0	0	0.006214	0	9	36									
KDM6A	7403	broad.mit.edu	37	X	44922802	44922802	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chrX:44922802C>T	uc004dge.3	+	16	2038	c.1663C>T	c.(1663-1665)CAG>TAG	p.Q555*	KDM6A_uc010nhk.2_Nonsense_Mutation_p.Q521*|KDM6A_uc011mkz.1_Nonsense_Mutation_p.Q607*|KDM6A_uc011mla.1_Nonsense_Mutation_p.Q510*|KDM6A_uc011mlb.1_Nonsense_Mutation_p.Q562*|KDM6A_uc011mlc.1_Nonsense_Mutation_p.Q259*|KDM6A_uc011mld.1_Nonsense_Mutation_p.Q194*	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	555					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TAGCGTCTCTCAGCCTGGAGT	0.567		NaN	D|N|F|S		renal|oesophageal SCC|MM								0	0	0	0.005443	0	27	12									
GPR173	54328	broad.mit.edu	37	X	53106253	53106253	+	Silent	SNP	G	G	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chrX:53106253G>A	uc004dru.2	+	2	708	c.450G>A	c.(448-450)CTG>CTA	p.L150L		NM_018969	NP_061842	Q9NS66	GP173_HUMAN	G protein-coupled receptor 173	150	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						CCTGGACCCTGTCTGTGGCCA	0.587		NaN											0	0	0	0.010729	0	12	19									
MAGEA10	4109	broad.mit.edu	37	X	151303231	151303231	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chrX:151303231C>T	uc004ffk.2	-	5	1270	c.862G>A	c.(862-864)GGC>AGC	p.G288S	MAGEA10_uc004ffl.2_Missense_Mutation_p.G288S	NM_001011543	NP_001011543	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	288	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					GGATCACTGCCAGGCACCTGC	0.522		NaN											0	0	0	0.01441	0	69	36									
OR8B2	26595	broad.mit.edu	37	11	124252689	124252690	+	Frame_Shift_Ins	INS	-	-	G			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr11:124252689_124252690insG	uc010sai.1	-	1	550_551	c.550_551insC	c.(550-552)CTCfs	p.L184fs		NM_001005468	NP_001005468	Q96RD0	OR8B2_HUMAN	olfactory receptor, family 8, subfamily B,	184	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		AAGCTGGAGGAGGGGGAGTATG	0.5		NaN											NaN	NaN	NaN	NaN	NaN	11	57	---	---							
SYT1	6857	broad.mit.edu	37	12	79842725	79842726	+	In_Frame_Ins	INS	-	-	ACA			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr12:79842725_79842726insACA	uc001sys.2	+	12	1761_1762	c.1090_1091insACA	c.(1090-1092)GAC>GACAAC	p.364_365insN	SYT1_uc001syt.2_In_Frame_Ins_p.364_365insN|SYT1_uc001syu.2_In_Frame_Ins_p.361_362insN|SYT1_uc001syv.2_In_Frame_Ins_p.364_365insN	NM_001135805	NP_001129277	P21579	SYT1_HUMAN	synaptotagmin I	364_365	Cytoplasmic (Potential).|Phospholipid binding (Probable).|C2 2.				detection of calcium ion|glutamate secretion|neurotransmitter secretion|protein homooligomerization	cell junction|chromaffin granule membrane|clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	1-phosphatidylinositol binding|low-density lipoprotein particle receptor binding|metal ion binding|syntaxin-1 binding|transporter activity			skin(3)|pancreas(2)|ovary(1)	6						AACTGTTTTGGACTATGACAAG	0.49		NaN											NaN	NaN	NaN	NaN	NaN	19	98	---	---							
ZFP36L1	677	broad.mit.edu	37	14	69256673	69256674	+	Frame_Shift_Ins	INS	-	-	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08			-	A	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr14:69256673_69256674insA	uc001xkh.1	-	2	723_724	c.593_594insT	c.(592-594)CTCfs	p.L198fs	ZFP36L1_uc001xki.1_Frame_Shift_Ins_p.L198fs	NM_004926	NP_004917	Q07352	TISB_HUMAN	butyrate response factor 1	198					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		AGCTATGCTGGAGGCGGGGACG	0.584		NaN									OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	NaN	NaN	NaN	NaN	NaN	29	29	---	---							
PDIA3	2923	broad.mit.edu	37	15	44055308	44055308	+	Frame_Shift_Del	DEL	C	C	-			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr15:44055308delC	uc001zsu.2	+	5	654	c.506delC	c.(505-507)TCCfs	p.S169fs	PDIA3_uc010bdp.2_Frame_Shift_Del_p.S149fs|PDIA3_uc010ued.1_5'UTR	NM_005313	NP_005304	P30101	PDIA3_HUMAN	protein disulfide-isomerase A3 precursor	169					cell redox homeostasis|glycerol ether metabolic process|post-translational protein modification|protein folding|protein import into nucleus|protein N-linked glycosylation via asparagine|protein retention in ER lumen|signal transduction	endoplasmic reticulum lumen|melanosome	cysteine-type endopeptidase activity|electron carrier activity|phospholipase C activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			ovary(1)|skin(1)	2		all_cancers(109;2.61e-15)|all_epithelial(112;1.12e-12)|Lung NSC(122;2.17e-08)|all_lung(180;2.45e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.48e-07)		GAGGCTCACTCCGAGTTCCTA	0.398		NaN											NaN	NaN	NaN	NaN	NaN	30	91	---	---							
ZFP36L2	678	broad.mit.edu	37	2	43452553	43452554	+	Frame_Shift_Ins	INS	-	-	C			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:43452553_43452554insC	uc002rsv.3	-	2	680_681	c.389_390insG	c.(388-390)CGCfs	p.R130fs	LOC100129726_uc010ynx.1_5'Flank	NM_006887	NP_008818	P47974	TISD_HUMAN	zinc finger protein 36, C3H type-like 2	130					cell proliferation	nucleus	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Acute lymphoblastic leukemia(82;0.00323)|all_hematologic(82;0.00824)				GGTGCTGGCTGCGATCGCCGTT	0.658		NaN											NaN	NaN	NaN	NaN	NaN	11	16	---	---							
OSBPL10	114884	broad.mit.edu	37	3	32022461	32022461	+	Frame_Shift_Del	DEL	G	G	-			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr3:32022461delG	uc003cev.2	-	2	592	c.211delC	c.(211-213)CGCfs	p.R71fs	OSBPL10_uc011axf.1_Frame_Shift_Del_p.R71fs|ZNF860_uc011axg.1_5'Flank	NM_017784	NP_060254	Q9BXB5	OSB10_HUMAN	oxysterol-binding protein-like protein 10	71					lipid transport		lipid binding			skin(1)	1				STAD - Stomach adenocarcinoma(1;0.00406)		TCCCTCCTGCGGCCGCCTCCC	0.642		NaN											NaN	NaN	NaN	NaN	NaN	8	5	---	---							
PLD1	5337	broad.mit.edu	37	3	171404550	171404550	+	Frame_Shift_Del	DEL	G	G	-			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr3:171404550delG	uc003fhs.2	-	16	1908	c.1792delC	c.(1792-1794)CATfs	p.H598fs	PLD1_uc003fht.2_Intron	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	598	Catalytic.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	TTTAAACCATGGATTAAATTG	0.333		NaN											NaN	NaN	NaN	NaN	NaN	56	153	---	---							
HES1	3280	broad.mit.edu	37	3	193854476	193854478	+	In_Frame_Del	DEL	TGA	TGA	-			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr3:193854476_193854478delTGA	uc003ftq.1	+	2	415_417	c.179_181delTGA	c.(178-183)CTGATT>CTT	p.I61del	HES1_uc011bst.1_In_Frame_Del_p.I61del	NM_005524	NP_005515	Q14469	HES1_HUMAN	hairy and enhancer of split 1	61	Helix-loop-helix motif.				endocrine pancreas development|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway	nucleus	histone deacetylase binding|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)	2	all_cancers(143;7.3e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;3.65e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;1.48e-05)		CTGAAAACACTGATTTTGGATGC	0.389		NaN											NaN	NaN	NaN	NaN	NaN	23	48	---	---							
PEX1	5189	broad.mit.edu	37	7	92146721	92146721	+	Frame_Shift_Del	DEL	T	T	-			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr7:92146721delT	uc003uly.2	-	5	1204	c.1108delA	c.(1108-1110)ATTfs	p.I370fs	PEX1_uc011khr.1_Frame_Shift_Del_p.I162fs|PEX1_uc010ley.2_Frame_Shift_Del_p.I370fs|PEX1_uc011khs.1_Intron|PEX1_uc011kht.1_RNA	NM_000466	NP_000457	O43933	PEX1_HUMAN	peroxin1	370					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)|central_nervous_system(1)	2	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			TCTGACCTAATTTTTTTTTGA	0.353		NaN											NaN	NaN	NaN	NaN	NaN	7	164	---	---							
EBF2	64641	broad.mit.edu	37	8	25718601	25718601	+	Frame_Shift_Del	DEL	C	C	-			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr8:25718601delC	uc003xes.1	-	13	1323	c.1306delG	c.(1306-1308)GTCfs	p.V436fs	PPP2R2A_uc003xek.2_Intron|EBF2_uc010lug.1_RNA	NM_022659	NP_073150	Q9HAK2	COE2_HUMAN	early B-cell factor 2	436					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			ovary(3)|skin(1)	4		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		GAGATGCTGACCCCAAGCTGG	0.493		NaN											NaN	NaN	NaN	NaN	NaN	53	63	---	---							
PHF20L1	51105	broad.mit.edu	37	8	133854841	133854842	+	Frame_Shift_Ins	INS	-	-	A			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr8:133854841_133854842insA	uc003ytt.2	+	19	2794_2795	c.2469_2470insA	c.(2467-2472)GAGAAAfs	p.E823fs	PHF20L1_uc011lja.1_Frame_Shift_Ins_p.E797fs	NM_016018	NP_057102	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1 isoform 1	823_824							nucleic acid binding|zinc ion binding			ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			CTGGGGTGGAGAAAAAAATAGC	0.381		NaN											NaN	NaN	NaN	NaN	NaN	12	26	---	---							
OR13C5	138799	broad.mit.edu	37	9	107361451	107361452	+	Frame_Shift_Del	DEL	GC	GC	-			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr9:107361451_107361452delGC	uc011lvp.1	-	1	243_244	c.243_244delGC	c.(241-246)ACGCTAfs	p.T81fs		NM_001004482	NP_001004482	Q8NGS8	O13C5_HUMAN	olfactory receptor, family 13, subfamily C,	81_82	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4						AAGCTCACTAGCGTGGAGGGAA	0.51		NaN											NaN	NaN	NaN	NaN	NaN	7	55	---	---							
PTPN3	5774	broad.mit.edu	37	9	112151578	112151590	+	Frame_Shift_Del	DEL	GCCAAAACTGTGC	GCCAAAACTGTGC	-			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr9:112151578_112151590delGCCAAAACTGTGC	uc004bed.2	-	22	2288_2300	c.2176_2188delGCACAGTTTTGGC	c.(2176-2190)GCACAGTTTTGGCAGfs	p.A726fs	PTPN3_uc004beb.2_Frame_Shift_Del_p.A595fs|PTPN3_uc004bec.2_Frame_Shift_Del_p.A550fs|PTPN3_uc010mtu.2_RNA|PTPN3_uc011lwg.1_Frame_Shift_Del_p.A681fs|PTPN3_uc011lwh.1_Frame_Shift_Del_p.A572fs|PTPN3_uc011lwd.1_Frame_Shift_Del_p.A194fs|PTPN3_uc011lwe.1_Frame_Shift_Del_p.A439fs|PTPN3_uc011lwf.1_Frame_Shift_Del_p.A394fs	NM_002829	NP_002820	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type	726_730	Tyrosine-protein phosphatase.				negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(3)	3						CAGACAACCTGCCAAAACTGTGCACAGGTATGC	0.465		NaN											NaN	NaN	NaN	NaN	NaN	16	21	---	---