Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
TAS1R3	83756	broad.mit.edu	37	1	1268136	1268136	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:1268136C>T	uc010nyk.1	+	3	1225	c.1225C>T	c.(1225-1227)CAG>TAG	p.Q409*		NM_152228	NP_689414	Q7RTX0	TS1R3_HUMAN	taste receptor, type 1, member 3 precursor	409	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste|sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.88e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.146)	Aspartame(DB00168)	CAACACTCTTCAGTGCAACGC	0.637		NaN											0	0	0	0.006122	0	15	51									
C1orf86	199990	broad.mit.edu	37	1	2125221	2125221	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:2125221C>T	uc001aiy.2	-	3	353	c.327G>A	c.(325-327)GGG>GGA	p.G109G	C1orf86_uc001aiv.1_RNA|C1orf86_uc001aiw.1_RNA|C1orf86_uc001aix.1_Missense_Mutation_p.G105D	NM_182533	NP_872339	Q6NZ36	CA086_HUMAN	hypothetical protein LOC199990 isoform 2	109											0	all_cancers(77;0.000134)|all_epithelial(69;4.45e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;1.14e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.09e-37)|OV - Ovarian serous cystadenocarcinoma(86;1.5e-23)|GBM - Glioblastoma multiforme(42;1.61e-08)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00437)|STAD - Stomach adenocarcinoma(132;0.0134)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		ATTCCAGGTGCCCTCCTGCCC	0.701		NaN											0	0	0	0.003163	0	16	28									
MMEL1	79258	broad.mit.edu	37	1	2526322	2526322	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:2526322G>A	uc001ajy.2	-	17	1809	c.1595C>T	c.(1594-1596)TCA>TTA	p.S532L	MMEL1_uc009vlg.1_RNA	NM_033467	NP_258428	Q495T6	MMEL1_HUMAN	membrane metallo-endopeptidase-like 1	532	Potential.|Lumenal (Potential).				proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity				0	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)		CAGGTCCTCTGAGAAGTTCAG	0.607		NaN											0	0	0	0.00361	0	47	41									
PER3	8863	broad.mit.edu	37	1	7902801	7902801	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:7902801G>C	uc001aoo.2	+	21	3767	c.3592G>C	c.(3592-3594)GAA>CAA	p.E1198Q	PER3_uc001aop.2_Missense_Mutation_p.E1207Q|PER3_uc010nzw.1_Missense_Mutation_p.E887Q	NM_016831	NP_058515	P56645	PER3_HUMAN	period 3	1198	CRY binding domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			ovary(1)|pancreas(1)|skin(1)	3	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		GGTTCTGGTAGAAGACAGCTG	0.453		NaN											0	0	0	0.00278	0	20	55									
DFFA	1676	broad.mit.edu	37	1	10529339	10529339	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:10529339C>G	uc001arj.2	-	2	291	c.193G>C	c.(193-195)GAG>CAG	p.E65Q	DFFA_uc001ark.2_Missense_Mutation_p.E65Q	NM_004401	NP_004392	O00273	DFFA_HUMAN	DNA fragmentation factor, 45kDa, alpha	65	CIDE-N.				DNA fragmentation involved in apoptotic nuclear change|intracellular signal transduction|negative regulation of apoptosis	cytosol|mitochondrion|nucleoplasm|plasma membrane	deoxyribonuclease activity|identical protein binding				0	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.25e-07)|COAD - Colon adenocarcinoma(227;7.25e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000296)|Kidney(185;0.00074)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0487)		GTGCCATCCTCTGCCAGGACC	0.428		NaN											0	0	0	0.007291	0	26	61									
EXOSC10	5394	broad.mit.edu	37	1	11132177	11132177	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:11132177C>A	uc001asa.2	-	20	2259	c.2209G>T	c.(2209-2211)GAA>TAA	p.E737*	EXOSC10_uc001asb.2_Nonsense_Mutation_p.E712*	NM_001001998	NP_001001998	Q01780	EXOSX_HUMAN	exosome component 10 isoform 1	737					CUT catabolic process|histone mRNA catabolic process|maturation of 5.8S rRNA|nuclear polyadenylation-dependent rRNA catabolic process|nuclear retention of unspliced pre-mRNA at the site of transcription|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasm|nuclear exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5' exonuclease activity|exoribonuclease activity|identical protein binding|nucleotide binding|protein serine/threonine kinase activity|RNA binding			upper_aerodigestive_tract(1)	1	Ovarian(185;0.249)	Lung NSC(185;1.74e-05)|all_lung(284;2.05e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.18e-07)|COAD - Colon adenocarcinoma(227;8.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000315)|Kidney(185;0.000832)|KIRC - Kidney renal clear cell carcinoma(229;0.00269)|READ - Rectum adenocarcinoma(331;0.0526)|STAD - Stomach adenocarcinoma(313;0.202)		TTGACAGCTTCTTTAGAGTCT	0.453		NaN											1	0	5.78141e-17	0.013114	6.17496e-17	34	70									
PLOD1	5351	broad.mit.edu	37	1	12020784	12020784	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:12020784G>A	uc001atm.2	+	10	1148	c.1057G>A	c.(1057-1059)GAG>AAG	p.E353K	PLOD1_uc010obb.1_Missense_Mutation_p.E400K	NM_000302	NP_000293	Q02809	PLOD1_HUMAN	lysyl hydroxylase 1 precursor	353					epidermis development|hydroxylysine biosynthetic process|protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein homodimerization activity			ovary(2)|breast(1)	3	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000809)|KIRC - Kidney renal clear cell carcinoma(229;0.00267)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)	Minoxidil(DB00350)|Succinic acid(DB00139)|Vitamin C(DB00126)	GGTGGGCCCTGAGGTGCGGAT	0.627		NaN											0	0	0	0.00361	0	58	39									
ATP13A2	23400	broad.mit.edu	37	1	17323611	17323611	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:17323611C>T	uc001baa.2	-	12	1289	c.1099G>A	c.(1099-1101)GAG>AAG	p.E367K	ATP13A2_uc001bab.2_Missense_Mutation_p.E362K|ATP13A2_uc001bac.2_Missense_Mutation_p.E362K|ATP13A2_uc009vpa.1_Missense_Mutation_p.E80K|ATP13A2_uc001bad.1_Missense_Mutation_p.E80K	NM_022089	NP_071372	Q9NQ11	AT132_HUMAN	ATPase type 13A2 isoform 1	367	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;0.000147)|Breast(348;0.00104)|Renal(390;0.00145)|Lung NSC(340;0.00566)|all_lung(284;0.00797)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|COAD - Colon adenocarcinoma(227;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;1.99e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)		CGGTGTGTCTCTGCACAGTAG	0.652		NaN											0	0	0	0.00361	0	130	68									
UBR4	23352	broad.mit.edu	37	1	19497282	19497282	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:19497282G>C	uc001bbi.2	-	26	3621	c.3617C>G	c.(3616-3618)TCT>TGT	p.S1206C	UBR4_uc001bbm.1_Missense_Mutation_p.S417C	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	1206					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		GCACCTGCTAGAGCCAATAGC	0.428		NaN											0	0	0	0.00361	0	71	37									
MYOM3	127294	broad.mit.edu	37	1	24387794	24387794	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:24387794C>T	uc001bin.3	-	34	4103	c.3940G>A	c.(3940-3942)GAG>AAG	p.E1314K	MYOM3_uc001bil.3_Missense_Mutation_p.E207K|MYOM3_uc001bim.3_Missense_Mutation_p.E971K	NM_152372	NP_689585	Q5VTT5	MYOM3_HUMAN	myomesin family, member 3	1314										skin(2)|ovary(1)	3		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		ATTGCATCCTCAAAAGCTATA	0.502		NaN											0	0	0	0.001368	0	10	27									
RHD	6007	broad.mit.edu	37	1	25599110	25599110	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:25599110C>T	uc001bjz.2	+	1	130	c.72C>T	c.(70-72)CTC>CTT	p.L24L	RHD_uc010oep.1_Silent_p.L24L|RHD_uc001bkc.2_Silent_p.L24L|RHD_uc009vrm.2_5'UTR|RHD_uc001bka.2_Silent_p.L24L|RHD_uc001bkb.2_Silent_p.L24L|RHD_uc009vrn.2_Silent_p.L24L|RHD_uc009vro.2_Silent_p.L24L|RHD_uc009vrp.2_Silent_p.L24L	NM_016124	NP_057208	Q02161	RHD_HUMAN	Rh blood group D antigen isoform 1	24	Helical; (Potential).					integral to plasma membrane				breast(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;7.39e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;6.43e-07)|STAD - Stomach adenocarcinoma(196;0.000332)|BRCA - Breast invasive adenocarcinoma(304;0.000438)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.000908)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		AAGCAGCTCTCATTCTCCTCT	0.532		NaN											0	0	0	0.010729	0	9	45									
SF3A3	10946	broad.mit.edu	37	1	38450421	38450421	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:38450421C>T	uc001cci.2	-	5	458	c.334G>A	c.(334-336)GAA>AAA	p.E112K	SF3A3_uc010oik.1_Missense_Mutation_p.E59K	NM_006802	NP_006793	Q12874	SF3A3_HUMAN	splicing factor 3a, subunit 3	112					nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nuclear speck	nucleic acid binding|protein binding|zinc ion binding				0	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				TTCAGGAGTTCCTCAAATTCC	0.353		NaN											0	0	0	0.013114	0	35	86									
MACF1	23499	broad.mit.edu	37	1	39782127	39782127	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:39782127G>C	uc010ois.1	+	29	3734	c.3529G>C	c.(3529-3531)GAG>CAG	p.E1177Q	MACF1_uc001cda.1_Missense_Mutation_p.E1085Q|MACF1_uc001cdc.1_Missense_Mutation_p.E264Q|MACF1_uc009vvq.1_Missense_Mutation_p.E234Q|MACF1_uc001cdb.1_Missense_Mutation_p.E264Q	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	1177					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CAAAGGTTATGAGATTAAGCT	0.433		NaN											0	0	0	0.00361	0	82	50									
EBNA1BP2	10969	broad.mit.edu	37	1	43637293	43637293	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:43637293G>A	uc001cin.2	-	3	377	c.180C>T	c.(178-180)TTC>TTT	p.F60F	EBNA1BP2_uc001cio.2_Silent_p.F115F|WDR65_uc010ojz.1_5'Flank|WDR65_uc001cip.1_5'Flank|WDR65_uc001ciq.1_5'Flank|EBNA1BP2_uc001cim.2_5'UTR|EBNA1BP2_uc010ojx.1_Silent_p.F115F|EBNA1BP2_uc010ojy.1_RNA	NM_006824	NP_006815	Q99848	EBP2_HUMAN	EBNA1 binding protein 2 isoform 2	60					ribosome biogenesis	membrane fraction|nucleolus	protein binding				0	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GATCCCGCTTGAATTCTGCCA	0.522		NaN											0	0	0	0.00361	0	146	109									
BEND5	79656	broad.mit.edu	37	1	49208411	49208411	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:49208411C>T	uc001crx.3	-	4	822	c.778G>A	c.(778-780)GAA>AAA	p.E260K	AGBL4_uc001cru.2_Intron|AGBL4_uc010omw.1_Intron|AGBL4_uc010omx.1_Intron|AGBL4_uc001crv.1_Intron|AGBL4_uc010omy.1_Intron|BEND5_uc001crw.3_Missense_Mutation_p.E91K	NM_024603	NP_078879	Q7L4P6	BEND5_HUMAN	BEN domain containing 5	260										skin(1)	1						TCGAGACATTCTGACTTTACT	0.443		NaN											0	0	0	0.000602	0	3	76									
EPS15	2060	broad.mit.edu	37	1	51913720	51913720	+	Missense_Mutation	SNP	T	T	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:51913720T>A	uc001csq.1	-	9	741	c.649A>T	c.(649-651)ACG>TCG	p.T217S	EPS15_uc009vyz.1_Missense_Mutation_p.T217S	NM_001981	NP_001972	P42566	EPS15_HUMAN	epidermal growth factor receptor pathway	217					cell proliferation|clathrin coat assembly|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|protein transport	cytosol|early endosome membrane	calcium ion binding|SH3 domain binding			lung(1)|kidney(1)	2						ATACTGACCGTTTTTCTCTTA	0.463		NaN	T	MLL	ALL								0	0	0	0.002299	0	19	59									
GADD45A	1647	broad.mit.edu	37	1	68152235	68152235	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:68152235G>A	uc001ddz.1	+	3	644	c.349G>A	c.(349-351)GAG>AAG	p.E117K	GADD45A_uc009wbb.1_Missense_Mutation_p.E83K|GADD45A_uc009wbc.1_Intron|GADD45A_uc009wbd.1_Intron	NM_001924	NP_001915	P24522	GA45A_HUMAN	growth arrest and DNA-damage-inducible, alpha	117					apoptosis|cell cycle arrest|cellular response to ionizing radiation|cellular response to mechanical stimulus|DNA repair|positive regulation of reactive oxygen species metabolic process|regulation of cyclin-dependent protein kinase activity|signal transduction in response to DNA damage	nucleus	protein binding			ovary(1)	1						CGAGGGCGCCGAGCAGCCCCC	0.706		NaN											0	0	0	0.00632	0	19	9									
CTH	1491	broad.mit.edu	37	1	70897772	70897772	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:70897772G>T	uc001dfd.2	+	8	875	c.731G>T	c.(730-732)GGA>GTA	p.G244V	CTH_uc009wbl.1_RNA|CTH_uc001dfe.2_Missense_Mutation_p.G200V|CTH_uc010oqq.1_Missense_Mutation_p.G212V	NM_001902	NP_001893	P32929	CGL_HUMAN	cystathionase isoform 1	244					cysteine biosynthetic process|hydrogen sulfide biosynthetic process|protein homotetramerization|protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine	cytoplasm|nucleus	cystathionine gamma-lyase activity|L-cysteine desulfhydrase activity|pyridoxal phosphate binding			lung(1)	1					L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	GCAGCTCTTGGAGCAGTTCCA	0.438		NaN											1	0	1.02788e-11	0.00499	1.07691e-11	14	35									
C1orf173	127254	broad.mit.edu	37	1	75037069	75037069	+	Nonsense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:75037069G>C	uc001dgg.2	-	14	4544	c.4325C>G	c.(4324-4326)TCA>TGA	p.S1442*		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1442	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						TCCTAGCCCTGAGGTCTTCCG	0.612		NaN											0	0	0	0.00361	0	58	159									
MAGI3	260425	broad.mit.edu	37	1	114128143	114128143	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:114128143G>A	uc001edk.2	+	4	869	c.688G>A	c.(688-690)GAA>AAA	p.E230K	MAGI3_uc001edh.3_Missense_Mutation_p.E230K|MAGI3_uc001edi.3_Missense_Mutation_p.E230K|MAGI3_uc010owm.1_Missense_Mutation_p.E230K	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	230	Guanylate kinase-like.				apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CAGCAAGATGGAAAGAATGGA	0.418		NaN											0	0	0	0.006122	0	17	34									
DENND2C	163259	broad.mit.edu	37	1	115147614	115147614	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:115147614C>T	uc001efd.1	-	11	2298	c.1596G>A	c.(1594-1596)GAG>GAA	p.E532E	DENND2C_uc001eez.2_RNA|DENND2C_uc001efc.1_Silent_p.E475E	NM_198459	NP_940861	Q68D51	DEN2C_HUMAN	DENN/MADD domain containing 2C	532	UDENN.									skin(3)	3	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTTTAAGTCTCTCTTCCATGT	0.343		NaN											0	0	0	0.001368	0	12	12									
DENND2C	163259	broad.mit.edu	37	1	115147649	115147649	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:115147649C>T	uc001efd.1	-	11	2263	c.1561G>A	c.(1561-1563)GAT>AAT	p.D521N	DENND2C_uc001eez.2_RNA|DENND2C_uc001efc.1_Missense_Mutation_p.D464N	NM_198459	NP_940861	Q68D51	DEN2C_HUMAN	DENN/MADD domain containing 2C	521	UDENN.									skin(3)	3	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TAGCCATGATCATCCTGAAAA	0.363		NaN											0	0	0	0.001168	0	6	8									
SPAG17	200162	broad.mit.edu	37	1	118624183	118624183	+	Silent	SNP	T	T	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:118624183T>C	uc001ehk.2	-	14	1913	c.1845A>G	c.(1843-1845)AAA>AAG	p.K615K		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	615						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TCAGTTTCCCTTTTTCATCAA	0.448		NaN											0	0	0	0.009096	0	3	87									
SPAG17	200162	broad.mit.edu	37	1	118640379	118640379	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:118640379C>T	uc001ehk.2	-	7	993	c.925G>A	c.(925-927)GAA>AAA	p.E309K		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	309						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		AGATTTGTTTCAGGTTTCTCA	0.373		NaN											0	0	0	0.001855	0	13	31									
NBPF9	400818	broad.mit.edu	37	1	144828683	144828683	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:144828683C>G	uc009wig.1	+	23	2804	c.2728C>G	c.(2728-2730)CAG>GAG	p.Q910E	NBPF9_uc010oxn.1_Missense_Mutation_p.Q808E|NBPF9_uc010oxo.1_Missense_Mutation_p.Q835E|NBPF9_uc010oxr.1_Missense_Mutation_p.Q937E|NBPF9_uc010oxt.1_Missense_Mutation_p.Q725E|NBPF9_uc001ekg.1_Missense_Mutation_p.Q237E|NBPF9_uc001ekk.1_Missense_Mutation_p.Q481E|NBPF10_uc009wir.2_Intron|NBPF9_uc010oyd.1_Missense_Mutation_p.Q237E|NBPF9_uc010oye.1_Intron|NBPF9_uc001eli.3_RNA|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|NBPF9_uc001elp.2_Missense_Mutation_p.Q570E|uc001elr.3_5'Flank	NM_001037675	NP_001032764	Q3BBV1	NBPFK_HUMAN	hypothetical protein LOC400818	910	NBPF 7.					cytoplasm					0						ATTTGAGGAACAGCACATCAG	0.438		NaN											0	0	0	0.003954	0	7	235									
NBPF9	400818	broad.mit.edu	37	1	144828688	144828688	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:144828688C>T	uc009wig.1	+	23	2809	c.2733C>T	c.(2731-2733)CAC>CAT	p.H911H	NBPF9_uc010oxn.1_Silent_p.H809H|NBPF9_uc010oxo.1_Silent_p.H836H|NBPF9_uc010oxr.1_Silent_p.H938H|NBPF9_uc010oxt.1_Silent_p.H726H|NBPF9_uc001ekg.1_Silent_p.H238H|NBPF9_uc001ekk.1_Silent_p.H482H|NBPF10_uc009wir.2_Intron|NBPF9_uc010oyd.1_Silent_p.H238H|NBPF9_uc010oye.1_Intron|NBPF9_uc001eli.3_RNA|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|NBPF9_uc001elp.2_Silent_p.H571H|uc001elr.3_5'Flank	NM_001037675	NP_001032764	Q3BBV1	NBPFK_HUMAN	hypothetical protein LOC400818	911	NBPF 7.					cytoplasm					0						AGGAACAGCACATCAGCTTCG	0.433		NaN											0	0	0	0.005443	0	8	228									
PDE4DIP	9659	broad.mit.edu	37	1	144857625	144857625	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:144857625G>A	uc001elw.3	-	39	6720	c.6429C>T	c.(6427-6429)ATC>ATT	p.I2143I	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Silent_p.I2037I|PDE4DIP_uc001elv.3_Silent_p.I1150I	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	2143					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TTGCTCTGTTGATTATGGGCG	0.468		NaN	T	PDGFRB	MPD								0	0	0	0.013114	0	35	289									
PDE4DIP	9659	broad.mit.edu	37	1	144871718	144871718	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:144871718C>A	uc001elw.3	-	32	5535	c.5244G>T	c.(5242-5244)ATG>ATT	p.M1748I	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Intron|PDE4DIP_uc001elv.3_Missense_Mutation_p.M755I	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1748	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GCTTCTGCAGCATCTGTAGCT	0.582		NaN	T	PDGFRB	MPD								1	0	0.00229938	0.002299	0.00233481	10	184									
PDE4DIP	9659	broad.mit.edu	37	1	144882662	144882662	+	Silent	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:144882662G>C	uc001elw.3	-	24	3648	c.3357C>G	c.(3355-3357)CTC>CTG	p.L1119L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Intron|PDE4DIP_uc001elv.3_Silent_p.L126L	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1119	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GTTGTTCTTTGAGGAGGTTGA	0.453		NaN	T	PDGFRB	MPD								0	0	0	0.005443	0	24	186									
GABPB2	126626	broad.mit.edu	37	1	151065682	151065682	+	Silent	SNP	G	G	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:151065682G>T	uc001ewr.2	+	4	622	c.291G>T	c.(289-291)GTG>GTT	p.V97V	GABPB2_uc010pcp.1_Silent_p.V113V|GABPB2_uc001ews.2_Silent_p.V57V|GABPB2_uc001ewt.2_5'UTR	NM_144618	NP_653219	Q8TAK5	GABP2_HUMAN	GA repeat binding protein, beta 2	97	ANK 3.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	protein heterodimerization activity|transcription regulatory region DNA binding				0				all cancers(107;7.17e-05)|GBM - Glioblastoma multiforme(94;0.000662)		GTGCAGATGTGAATGCCAAGG	0.443		NaN											1	0	2.51308e-46	0.00361	2.75103e-46	90	168									
ZNF687	57592	broad.mit.edu	37	1	151258795	151258795	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:151258795G>C	uc001exq.2	+	2	126	c.28G>C	c.(28-30)GAT>CAT	p.D10H	ZNF687_uc001exp.1_Missense_Mutation_p.D19H|ZNF687_uc009wmo.2_Missense_Mutation_p.D10H|ZNF687_uc009wmp.2_Missense_Mutation_p.D10H	NM_020832	NP_065883	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	10					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CCCTGATTTTGATGACCTCCT	0.517		NaN											0	0	0	0.00361	0	216	139									
HRNR	388697	broad.mit.edu	37	1	152191810	152191810	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:152191810G>A	uc001ezt.1	-	3	2371	c.2295C>T	c.(2293-2295)CAC>CAT	p.H765H		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	765	8.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTTGTCGGCCGTGGCCCGAAG	0.592		NaN											0	0	0	0.003271	0	32	167									
HRNR	388697	broad.mit.edu	37	1	152193146	152193146	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:152193146G>C	uc001ezt.1	-	3	1035	c.959C>G	c.(958-960)TCC>TGC	p.S320C		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	320	3.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCGTGGCTGGAGGAGTGCCC	0.607		NaN											0	0	0	0.007291	0	27	119									
HRNR	388697	broad.mit.edu	37	1	152193539	152193539	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:152193539G>T	uc001ezt.1	-	3	642	c.566C>A	c.(565-567)TCT>TAT	p.S189Y		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	189	2.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCGGCCTGAAGACTGATGGGA	0.537		NaN											1	0	2.32416e-17	0.002299	2.49044e-17	5	75									
CLK2	1196	broad.mit.edu	37	1	155234440	155234440	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:155234440G>A	uc001fjy.2	-	9	1349	c.1059C>T	c.(1057-1059)ATC>ATT	p.I353I	RAG1AP1_uc010pey.1_Intron|SCAMP3_uc001fjs.2_5'Flank|SCAMP3_uc001fju.2_5'Flank|SCAMP3_uc001fjv.2_5'Flank|SCAMP3_uc001fjt.2_5'Flank|CLK2_uc001fjw.2_Silent_p.I352I|CLK2_uc001fjx.2_Silent_p.I125I|CLK2_uc009wqm.2_Silent_p.I353I	NM_003993	NP_003984	P49760	CLK2_HUMAN	CDC-like kinase 2	353	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CCTTACCAAGGATGACTTCTG	0.552		NaN						Other_conserved_DNA_damage_response_genes					0	0	0	0.00361	0	37	156									
YY1AP1	55249	broad.mit.edu	37	1	155630385	155630385	+	Nonsense_Mutation	SNP	G	G	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:155630385G>T	uc001fln.2	-	11	1478	c.1454C>A	c.(1453-1455)TCA>TAA	p.S485*	YY1AP1_uc001flg.2_Nonsense_Mutation_p.S224*|YY1AP1_uc010pgg.1_Nonsense_Mutation_p.S324*|YY1AP1_uc010pgh.1_Nonsense_Mutation_p.S428*|YY1AP1_uc010pgi.1_Nonsense_Mutation_p.S577*|YY1AP1_uc001flh.2_Nonsense_Mutation_p.S557*|YY1AP1_uc009wqt.2_Nonsense_Mutation_p.S408*|YY1AP1_uc001flk.2_Nonsense_Mutation_p.S428*|YY1AP1_uc001fll.2_Nonsense_Mutation_p.S439*|YY1AP1_uc009wqv.2_Nonsense_Mutation_p.S156*|YY1AP1_uc001flm.2_Nonsense_Mutation_p.S428*|YY1AP1_uc001fli.2_Nonsense_Mutation_p.S439*|YY1AP1_uc009wqu.2_Nonsense_Mutation_p.S272*|YY1AP1_uc001flj.2_Nonsense_Mutation_p.S419*|YY1AP1_uc009wqw.2_Nonsense_Mutation_p.S408*|YY1AP1_uc001flo.2_Nonsense_Mutation_p.S373*|YY1AP1_uc001flp.2_Nonsense_Mutation_p.S439*|YY1AP1_uc010pgj.1_3'UTR	NM_139118	NP_620829	Q9H869	YYAP1_HUMAN	YY1-associated protein isoform 2	485					regulation of cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					AGGGGCTTCTGAATGAGTTGA	0.552		NaN											1	0	3.52435e-65	0.00361	3.89036e-65	114	69									
KIAA0907	22889	broad.mit.edu	37	1	155891202	155891202	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:155891202C>T	uc001fmi.1	-	10	1254	c.1230G>A	c.(1228-1230)CCG>CCA	p.P410P	KIAA0907_uc001fmj.1_Silent_p.P410P|KIAA0907_uc009wrk.1_Silent_p.P267P|KIAA0907_uc009wrl.1_RNA|SNORA42_uc001fmk.1_5'Flank|KIAA0907_uc001fml.1_Missense_Mutation_p.D377N	NM_014949	NP_055764	Q7Z7F0	K0907_HUMAN	hypothetical protein LOC22889	410	Pro-rich.										0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)			CTTGTGTTATCGGGTATTGTG	0.493		NaN											0	0	0	0.005443	0	23	100									
KIAA0907	22889	broad.mit.edu	37	1	155903521	155903521	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:155903521G>A	uc001fmi.1	-	2	182	c.158C>T	c.(157-159)TCA>TTA	p.S53L	KIAA0907_uc001fmj.1_Missense_Mutation_p.S53L|KIAA0907_uc009wrk.1_Missense_Mutation_p.S53L|KIAA0907_uc009wrl.1_RNA|KIAA0907_uc001fml.1_Missense_Mutation_p.S53L|KIAA0907_uc001fmm.2_Missense_Mutation_p.S53L|KIAA0907_uc001fmo.2_Missense_Mutation_p.S53L	NM_014949	NP_055764	Q7Z7F0	K0907_HUMAN	hypothetical protein LOC22889	53											0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)			CAAGGCTCCTGAAGGAGCAGC	0.592		NaN											0	0	0	0.006214	0	10	22									
SMG5	23381	broad.mit.edu	37	1	156230257	156230257	+	Silent	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:156230257G>C	uc001foc.3	-	15	2417	c.2268C>G	c.(2266-2268)CTC>CTG	p.L756L	SMG5_uc009wrv.2_Silent_p.L241L	NM_015327	NP_056142	Q9UPR3	SMG5_HUMAN	SMG5 homolog nonsense mediated mRNA decay	756					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			ovary(2)|skin(2)|pancreas(1)	5	Hepatocellular(266;0.158)					CTAAGGTGCTGAGCAGGGGCC	0.562		NaN											0	0	0	0.00361	0	49	161									
SMG5	23381	broad.mit.edu	37	1	156247764	156247764	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:156247764C>G	uc001foc.3	-	3	398	c.249G>C	c.(247-249)TGG>TGC	p.W83C		NM_015327	NP_056142	Q9UPR3	SMG5_HUMAN	SMG5 homolog nonsense mediated mRNA decay	83					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			ovary(2)|skin(2)|pancreas(1)	5	Hepatocellular(266;0.158)					ATACCTTTCTCCACAGCAGCT	0.493		NaN											0	0	0	0.009535	0	29	143									
SMG5	23381	broad.mit.edu	37	1	156247778	156247778	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:156247778C>T	uc001foc.3	-	3	384	c.235G>A	c.(235-237)GAG>AAG	p.E79K		NM_015327	NP_056142	Q9UPR3	SMG5_HUMAN	SMG5 homolog nonsense mediated mRNA decay	79					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			ovary(2)|skin(2)|pancreas(1)	5	Hepatocellular(266;0.158)					AGCAGCTCCTCAGCCTTTCTC	0.502		NaN											0	0	0	0.007291	0	28	118									
CCT3	7203	broad.mit.edu	37	1	156279057	156279057	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:156279057G>A	uc001fol.1	-	14	1791	c.1571C>T	c.(1570-1572)TCA>TTA	p.S524L	CCT3_uc001fom.1_Missense_Mutation_p.S523L|CCT3_uc001fon.1_Missense_Mutation_p.S486L|CCT3_uc010phj.1_Missense_Mutation_p.S478L|CCT3_uc010phk.1_Missense_Mutation_p.S478L|CCT3_uc010phl.1_Missense_Mutation_p.S478L	NM_005998	NP_005989	P49368	TCPG_HUMAN	chaperonin containing TCP1, subunit 3 isoform a	524					'de novo' posttranslational protein folding	cytoskeleton|cytosol|plasma membrane	ATP binding|unfolded protein binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.158)					TTTGTGGCCTGAAACGATGTC	0.512		NaN											0	0	0	0.00623	0	37	183									
C1orf66	51093	broad.mit.edu	37	1	156698908	156698908	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:156698908C>T	uc001fpu.2	+	1	646	c.12C>T	c.(10-12)ATC>ATT	p.I4I	ISG20L2_uc001fps.1_5'Flank|ISG20L2_uc001fpt.1_5'Flank|C1orf66_uc001fpv.2_Silent_p.I4I	NM_015997	NP_057081	Q96FB5	RRNAD_HUMAN	hypothetical protein LOC51093 isoform 1	4						integral to membrane	rRNA (adenine-N6,N6-)-dimethyltransferase activity				0	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TGCCGGGCATCTCCGCCCGAG	0.642		NaN											0	0	0	0.008291	0	10	36									
OR10X1	128367	broad.mit.edu	37	1	158549345	158549345	+	Missense_Mutation	SNP	T	T	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:158549345T>A	uc010pin.1	-	1	345	c.345A>T	c.(343-345)TTA>TTT	p.L115F		NM_001004477	NP_001004477	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X,	115	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					AGCACATCTGTAAGCTACAAC	0.478		NaN											0	0	0	0.005443	0	23	129									
OR6N2	81442	broad.mit.edu	37	1	158747168	158747168	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:158747168G>A	uc010pir.1	-	1	258	c.258C>T	c.(256-258)CTC>CTT	p.L86L		NM_001005278	NP_001005278	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N,	86	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_hematologic(112;0.0378)					TCTTCTCACTGAGAATATTAG	0.453		NaN											0	0	0	0.006214	0	9	232									
IFI16	3428	broad.mit.edu	37	1	158985757	158985757	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:158985757G>C	uc001ftf.1	+	4	968	c.361G>C	c.(361-363)GAG>CAG	p.E121Q	IFI16_uc001ftg.2_Missense_Mutation_p.E121Q|IFI16_uc010pis.1_Missense_Mutation_p.E121Q	NM_005531	NP_005522	Q16666	IF16_HUMAN	interferon, gamma-inducible protein 16	121	Lys-rich.				cell proliferation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|monocyte differentiation|negative regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	cytoplasm|nuclear speck|nucleolus	double-stranded DNA binding|protein binding			ovary(1)	1	all_hematologic(112;0.0429)					TGAAGGAGCAGAGGCAACTCC	0.522		NaN											0	0	0	0.004878	0	33	84									
CADM3	57863	broad.mit.edu	37	1	159161793	159161793	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:159161793G>A	uc001ftl.2	+	2	298	c.156G>A	c.(154-156)GTG>GTA	p.V52V	CADM3_uc009wsx.1_Silent_p.V86V|CADM3_uc009wsy.1_Silent_p.V52V|CADM3_uc001ftk.2_Silent_p.V86V	NM_001127173	NP_001120645	Q8N126	CADM3_HUMAN	cell adhesion molecule 3 isoform 2	52	Ig-like V-type.|Extracellular (Potential).				adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			ovary(2)	2	all_hematologic(112;0.0429)					AGTGCCAAGTGAAAGATCACG	0.512		NaN											0	0	0	0.00361	0	91	57									
CADM3	57863	broad.mit.edu	37	1	159161862	159161862	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:159161862G>A	uc001ftl.2	+	2	367	c.225G>A	c.(223-225)AAG>AAA	p.K75K	CADM3_uc009wsx.1_Silent_p.K109K|CADM3_uc009wsy.1_Silent_p.K75K|CADM3_uc001ftk.2_Silent_p.K109K	NM_001127173	NP_001120645	Q8N126	CADM3_HUMAN	cell adhesion molecule 3 isoform 2	75	Ig-like V-type.|Extracellular (Potential).				adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			ovary(2)	2	all_hematologic(112;0.0429)					TTGGGGAGAAGAGAGGTAGTA	0.527		NaN											0	0	0	0.00361	0	55	36									
COPA	1314	broad.mit.edu	37	1	160267134	160267134	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:160267134C>G	uc009wti.2	-	21	2656	c.2262G>C	c.(2260-2262)CAG>CAC	p.Q754H	COPA_uc001fvv.3_Missense_Mutation_p.Q763H	NM_004371	NP_004362	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha isoform	754					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			ovary(1)|skin(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GATACTTACTCTGTCCACAGT	0.453		NaN											0	0	0	0.00361	0	39	338									
USP21	27005	broad.mit.edu	37	1	161130796	161130796	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:161130796G>A	uc010pke.1	+	3	743	c.366G>A	c.(364-366)ATG>ATA	p.M122I	USP21_uc010pkc.1_Missense_Mutation_p.M122I|USP21_uc010pkd.1_Missense_Mutation_p.M122I|USP21_uc010pkf.1_Missense_Mutation_p.M122I	NM_001014443	NP_001014443	Q9UK80	UBP21_HUMAN	ubiquitin-specific protease 21	122					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding|NEDD8-specific protease activity|protein binding|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|lung(1)|prostate(1)|breast(1)	5	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			TGCGTCCAATGGGGATTGCCT	0.632		NaN											0	0	0	0.00632	0	24	209									
ATF6	22926	broad.mit.edu	37	1	161789498	161789498	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:161789498G>C	uc001gbr.2	+	8	1052	c.985G>C	c.(985-987)GAA>CAA	p.E329Q	ATF6_uc001gbq.1_Missense_Mutation_p.E329Q	NM_007348	NP_031374	P18850	ATF6A_HUMAN	activating transcription factor 6	329	Cytoplasmic (Potential).				positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|protein folding	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|skin(1)	3	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.00953)			GAAGAAGAAAGAATATATGCT	0.413		NaN											0	0	0	0.001984	0	7	93									
DUSP27	92235	broad.mit.edu	37	1	167096654	167096654	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:167096654C>A	uc001geb.1	+	5	2286	c.2286C>A	c.(2284-2286)TGC>TGA	p.C762*		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	762					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						CGGCTAGCTGCCTGGGGGATG	0.562		NaN											1	0	6.13486e-44	0.00361	6.7046e-44	102	33									
SCYL3	57147	broad.mit.edu	37	1	169847945	169847945	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:169847945G>A	uc001ggs.2	-	3	379	c.181C>T	c.(181-183)CGT>TGT	p.R61C	SCYL3_uc001ggt.2_Missense_Mutation_p.R61C|SCYL3_uc001ggu.2_RNA	NM_181093	NP_851607	Q8IZE3	PACE1_HUMAN	SCY1-like 3 isoform 2	61	Protein kinase.				cell migration	Golgi apparatus|lamellipodium	ATP binding|protein binding|protein kinase activity			ovary(1)|skin(1)	2	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CAAGGGTGACGAAGTGTCTTC	0.408		NaN											0	0	0	0.00361	0	113	41									
FMO2	2327	broad.mit.edu	37	1	171174608	171174608	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:171174608G>T	uc001ghk.1	+	7	1135	c.1018G>T	c.(1018-1020)GAT>TAT	p.D340Y	FMO2_uc010pmd.1_Missense_Mutation_p.D120Y	NM_001460	NP_001451	Q99518	FMO2_HUMAN	flavin containing monooxygenase 2	340					drug metabolic process|NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|host cell microsome|integral to membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CTTCCTTGAAGATTCACTCGT	0.418		NaN											1	0	0.000673444	0.008291	0.000686996	10	27									
FMO4	2329	broad.mit.edu	37	1	171292305	171292305	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:171292305G>C	uc001gho.2	+	4	512	c.295G>C	c.(295-297)GAC>CAC	p.D99H		NM_002022	NP_002013	P31512	FMO4_HUMAN	flavin containing monooxygenase 4	99					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			kidney(2)|skin(1)	3	all_cancers(6;3.9e-08)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					TGAGCACTTTGACCTCCTGAA	0.373		NaN											0	0	0	0.00874	0	32	44									
FMO4	2329	broad.mit.edu	37	1	171293307	171293307	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:171293307G>C	uc001gho.2	+	5	569	c.352G>C	c.(352-354)GAC>CAC	p.D118H		NM_002022	NP_002013	P31512	FMO4_HUMAN	flavin containing monooxygenase 4	118					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			kidney(2)|skin(1)	3	all_cancers(6;3.9e-08)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					GAAGCGTCCAGACTTCTCCGA	0.463		NaN											0	0	0	0.00361	0	123	247									
FMO4	2329	broad.mit.edu	37	1	171293376	171293376	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:171293376G>C	uc001gho.2	+	5	638	c.421G>C	c.(421-423)GAT>CAT	p.D141H		NM_002022	NP_002013	P31512	FMO4_HUMAN	flavin containing monooxygenase 4	141					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			kidney(2)|skin(1)	3	all_cancers(6;3.9e-08)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					AGCTGTCTTTGATGCTGTTAT	0.478		NaN											0	0	0	0.00361	0	260	469									
TNN	63923	broad.mit.edu	37	1	175087808	175087808	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:175087808C>G	uc001gkl.1	+	11	2611	c.2498C>G	c.(2497-2499)TCT>TGT	p.S833C		NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	833	Fibronectin type-III 7.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		CACTACACGTCTGCCAACGGA	0.612		NaN											0	0	0	0.00361	0	125	42									
MR1	3140	broad.mit.edu	37	1	181019244	181019244	+	Silent	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:181019244G>C	uc001goq.1	+	3	431	c.426G>C	c.(424-426)CTG>CTC	p.L142L	MR1_uc001gop.2_Silent_p.L142L|MR1_uc001gor.1_Intron|MR1_uc001gos.1_Silent_p.L142L|MR1_uc010pns.1_Silent_p.L142L	NM_001531	NP_001522	Q95460	HMR1_HUMAN	major histocompatibility complex, class	142	Extracellular (Potential).|Ligand-binding.|Alpha-2.				antigen processing and presentation of peptide antigen via MHC class I|immune response	endoplasmic reticulum|extracellular region|integral to membrane|MHC class I protein complex	MHC class I receptor activity			skin(1)	1						AGGATTTCCTGATCTTCAATA	0.498		NaN											0	0	0	0.009718	0	39	47									
UCHL5	51377	broad.mit.edu	37	1	193028361	193028361	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:193028361G>A	uc001gsm.2	-	1	161	c.30C>T	c.(28-30)CTC>CTT	p.L10L	UCHL5_uc001gsn.2_RNA|UCHL5_uc001gso.2_Silent_p.L10L|UCHL5_uc010pov.1_RNA|UCHL5_uc001gsp.2_Silent_p.L10L|UCHL5_uc001gsq.2_Silent_p.L10L|UCHL5_uc010pow.1_Intron|UCHL5_uc010pox.1_5'UTR|UCHL5_uc001gsr.1_3'UTR|TROVE2_uc001gst.1_5'Flank|TROVE2_uc001gss.2_5'Flank|TROVE2_uc001gsu.1_5'Flank|TROVE2_uc001gsv.1_5'Flank|TROVE2_uc001gsw.2_5'Flank|TROVE2_uc009wyp.2_5'Flank|TROVE2_uc009wyq.2_5'Flank	NM_015984	NP_057068	Q9Y5K5	UCHL5_HUMAN	ubiquitin carboxyl-terminal hydrolase L5	10					DNA recombination|DNA repair|protein deubiquitination|regulation of proteasomal protein catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytosol|Ino80 complex|proteasome complex	endopeptidase inhibitor activity|omega peptidase activity|proteasome binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|ovary(1)	3						CGCTTTCCATGAGGCACCACT	0.677		NaN											0	0	0	0.004007	0	13	41									
CRB1	23418	broad.mit.edu	37	1	197398672	197398672	+	Nonsense_Mutation	SNP	G	G	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:197398672G>T	uc001gtz.2	+	8	2905	c.2770G>T	c.(2770-2772)GAG>TAG	p.E924*	CRB1_uc010poz.1_Nonsense_Mutation_p.E900*|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Nonsense_Mutation_p.E812*|CRB1_uc010ppb.1_Intron|CRB1_uc010ppd.1_Nonsense_Mutation_p.E405*|CRB1_uc001gub.1_Nonsense_Mutation_p.E573*	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	924	Extracellular (Potential).|EGF-like 14.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						AGCCTGTGAGGAGGTTCAGTG	0.547		NaN											1	0	8.16721e-17	0.010818	8.70905e-17	28	62									
ZNF281	23528	broad.mit.edu	37	1	200376276	200376276	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:200376276G>C	uc001gve.2	-	2	2665	c.2558C>G	c.(2557-2559)TCT>TGT	p.S853C	ZNF281_uc001gvf.1_Missense_Mutation_p.S853C|ZNF281_uc001gvg.1_Missense_Mutation_p.S817C	NM_012482	NP_036614	Q9Y2X9	ZN281_HUMAN	zinc finger protein 281	853					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|breast(1)	2						TTCTCCATTAGAGTTAGTGAT	0.418		NaN											0	0	0	0.00333	0	24	48									
ADIPOR1	51094	broad.mit.edu	37	1	202917512	202917512	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:202917512C>T	uc001gyq.3	-	3	445	c.178G>A	c.(178-180)GAA>AAA	p.E60K	ADIPOR1_uc010pqd.1_5'UTR|ADIPOR1_uc001gyr.3_5'UTR|ADIPOR1_uc001gys.3_Missense_Mutation_p.E60K	NM_015999	NP_057083	Q96A54	ADR1_HUMAN	adiponectin receptor 1	60	Cytoplasmic (Potential).				fatty acid oxidation|hormone-mediated signaling pathway	integral to membrane|plasma membrane	hormone binding|protein kinase binding|receptor activity				0			BRCA - Breast invasive adenocarcinoma(75;0.141)			TCCTCCTCTTCTTCCTGGGGC	0.507		NaN											0	0	0	0.001368	0	11	48									
USH2A	7399	broad.mit.edu	37	1	216465553	216465553	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:216465553C>G	uc001hku.1	-	10	2191	c.1804G>C	c.(1804-1806)GGA>CGA	p.G602R	USH2A_uc001hkv.2_Missense_Mutation_p.G602R	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	602	Laminin EGF-like 2.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CAAACTCCTCCTCCCCCTCTG	0.423		NaN								HNSCC(13;0.011)			0	0	0	0.011902	0	35	173									
ESRRG	2104	broad.mit.edu	37	1	216850701	216850701	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:216850701G>A	uc001hkw.1	-	2	355	c.189C>T	c.(187-189)GAC>GAT	p.D63D	ESRRG_uc001hky.1_Silent_p.D40D|ESRRG_uc009xdp.1_Silent_p.D40D|ESRRG_uc001hkz.1_Silent_p.D40D|ESRRG_uc010puc.1_Silent_p.D40D|ESRRG_uc001hla.1_Silent_p.D40D|ESRRG_uc001hlb.1_Silent_p.D40D|ESRRG_uc010pud.1_Intron|ESRRG_uc001hlc.1_Silent_p.D40D|ESRRG_uc001hld.1_Silent_p.D40D|ESRRG_uc001hkx.1_Silent_p.D68D|ESRRG_uc009xdo.1_Silent_p.D40D|ESRRG_uc001hle.1_Silent_p.D40D	NM_001438	NP_001429	P62508	ERR3_HUMAN	estrogen-related receptor gamma isoform 1	63					positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|kidney(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)	TCCCACTGGCGTCTGAAGAGC	0.572		NaN											0	0	0	0.007835	0	39	77									
SLC30A10	55532	broad.mit.edu	37	1	220089088	220089088	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:220089088C>A	uc001hlw.2	-	4	1372	c.1161G>T	c.(1159-1161)TTG>TTT	p.L387F	SLC30A10_uc001hlu.1_Intron|SLC30A10_uc001hlv.2_Missense_Mutation_p.L142F|SLC30A10_uc001hlx.2_Missense_Mutation_p.L162F	NM_018713	NP_061183	Q6XR72	ZNT10_HUMAN	solute carrier family 30 (zinc transporter),	387	Cytoplasmic (Potential).				zinc ion transport	integral to membrane|plasma membrane	cation transmembrane transporter activity				0				GBM - Glioblastoma multiforme(131;0.051)|all cancers(67;0.209)		GGGGTTCCTTCAAGTCCACAT	0.517		NaN											1	0	2.79863e-10	0.004656	2.90899e-10	25	130									
C1orf65	164127	broad.mit.edu	37	1	223566977	223566977	+	Missense_Mutation	SNP	G	G	A	rs143800669		TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:223566977G>A	uc001hoa.2	+	1	263	c.160G>A	c.(160-162)GAA>AAA	p.E54K		NM_152610	NP_689823	Q8N715	CA065_HUMAN	hypothetical protein LOC164127	54								p.E54K(1)		central_nervous_system(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0704)		TGCGGAGAGCGAAGCTGGGGC	0.736		NaN											0	0	0	0.00361	0	45	15									
GALNT2	2590	broad.mit.edu	37	1	230415081	230415081	+	Silent	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:230415081G>C	uc010pwa.1	+	16	1665	c.1593G>C	c.(1591-1593)CTG>CTC	p.L531L	GALNT2_uc010pvy.1_Silent_p.L493L|GALNT2_uc001htu.2_Silent_p.L143L	NM_004481	NP_004472	Q10471	GALT2_HUMAN	polypeptide N-acetylgalactosaminyltransferase 2	531	Lumenal (Potential).|Ricin B-type lectin.				immunoglobulin biosynthetic process|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2	Breast(184;0.193)|Ovarian(103;0.249)	all_cancers(173;0.156)|Prostate(94;0.179)				ACTCCAAGCTGAGGCACGTGG	0.582		NaN											0	0	0	0.012319	0	18	60									
ARID4B	51742	broad.mit.edu	37	1	235383127	235383127	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:235383127C>A	uc001hwq.2	-	16	2062	c.1564G>T	c.(1564-1566)GAA>TAA	p.E522*	ARID4B_uc001hwr.2_Nonsense_Mutation_p.E522*|ARID4B_uc001hws.3_Nonsense_Mutation_p.E522*|ARID4B_uc001hwt.3_Nonsense_Mutation_p.E203*	NM_016374	NP_057458	Q4LE39	ARI4B_HUMAN	AT rich interactive domain 4B isoform 1	522	Glu-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			ovary(2)|lung(1)	3	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)			GCTTTTTCTTCCTCAGCTTCT	0.338		NaN											1	0	3.5997e-14	0.002299	3.80161e-14	17	58									
ARID4B	51742	broad.mit.edu	37	1	235383646	235383646	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:235383646C>T	uc001hwq.2	-	15	1876	c.1378G>A	c.(1378-1380)GAA>AAA	p.E460K	ARID4B_uc001hwr.2_Missense_Mutation_p.E460K|ARID4B_uc001hws.3_Missense_Mutation_p.E460K|ARID4B_uc001hwt.3_Missense_Mutation_p.E141K	NM_016374	NP_057458	Q4LE39	ARI4B_HUMAN	AT rich interactive domain 4B isoform 1	460	Glu-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			ovary(2)|lung(1)	3	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)			TCTTTTCTTTCAATTTCATCC	0.308		NaN											0	0	0	0.004482	0	8	31									
TBCE	6905	broad.mit.edu	37	1	235611710	235611710	+	Silent	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:235611710C>G	uc001hwz.1	+	16	1569	c.1446C>G	c.(1444-1446)CTC>CTG	p.L482L	TBCE_uc001hxa.1_Silent_p.L482L|TBCE_uc010pxr.1_Silent_p.L533L|TBCE_uc001hxb.1_Silent_p.L369L|B3GALNT2_uc001hxc.2_3'UTR	NM_003193	NP_003184	Q15813	TBCE_HUMAN	beta-tubulin cofactor E	482					'de novo' posttranslational protein folding|post-chaperonin tubulin folding pathway	cytoplasm|microtubule|nucleus|plasma membrane	chaperone binding				0	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00192)|Prostate(94;0.0294)|all_epithelial(177;0.155)|Lung SC(1967;0.238)	OV - Ovarian serous cystadenocarcinoma(106;2.56e-05)			CACGTCTTCTCAAAGTTCCTG	0.403		NaN											0	0	0	0.004289	0	28	117									
FH	2271	broad.mit.edu	37	1	241663770	241663770	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:241663770G>C	uc001hyx.2	-	9	1389	c.1357C>G	c.(1357-1359)CTA>GTA	p.L453V		NM_000143	NP_000134	P07954	FUMH_HUMAN	fumarate hydratase precursor	453					fumarate metabolic process|tricarboxylic acid cycle	cell junction|mitochondrial matrix|tricarboxylic acid cycle enzyme complex	fumarate hydratase activity			lung(3)|ovary(1)|skin(1)	5	Ovarian(103;0.103)	all_cancers(173;2.37e-314)|all_epithelial(177;5.17e-286)|Breast(1374;1.06e-10)|Acute lymphoblastic leukemia(190;4.93e-10)|all_neural(198;0.00118)	OV - Ovarian serous cystadenocarcinoma(106;0.0214)	Colorectal(1306;2.33e-53)|COAD - Colon adenocarcinoma(196;1.05e-44)|KIRC - Kidney renal clear cell carcinoma(1967;0.000109)		ACCAACATTAGAGACTCATTC	0.388		NaN	Mis|N|F			lieomyomatosis|renal			Hereditary_Leiomyomatosis_and_Renal_Cell_Cancer				0	0	0	0.00361	0	134	70									
OR1C1	26188	broad.mit.edu	37	1	247920818	247920818	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:247920818C>T	uc010pza.1	-	1	891	c.891G>A	c.(889-891)ATG>ATA	p.M297I		NM_012353	NP_036485	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C,	297	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			GTCCCCTCTTCATATCCCTGT	0.428		NaN											0	0	0	0.00361	0	61	46									
PFKP	5214	broad.mit.edu	37	10	3155563	3155563	+	Splice_Site	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr10:3155563G>A	uc001igp.2	+	13	1261	c.1225_splice	c.e13-1	p.T409_splice	PFKP_uc001igq.2_Splice_Site_p.T401_splice|PFKP_uc009xhr.2_Splice_Site_p.T371_splice|PFKP_uc009xhs.1_Splice_Site_p.T193_splice|PFKP_uc009xht.2_Splice_Site_p.T147_splice|PFKP_uc009xhu.2_5'Flank	NM_002627	NP_002618	Q01813	K6PP_HUMAN	phosphofructokinase, platelet						glycolysis	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|metal ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)|lung(1)	3				GBM - Glioblastoma multiforme(1;0.000975)|all cancers(11;0.00351)|Epithelial(11;0.142)		CTGTTTTGCAGACCAATTGCA	0.607		NaN											0	0	0	0.001984	0	6	35									
FAM171A1	221061	broad.mit.edu	37	10	15326105	15326105	+	Splice_Site	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr10:15326105C>G	uc001iob.2	-	2	105	c.98_splice	c.e2-1	p.E33_splice		NM_001010924	NP_001010924	Q5VUB5	F1711_HUMAN	hypothetical protein LOC221061 precursor							integral to membrane				ovary(2)|breast(1)|skin(1)	4						AACGTCACCTCTGGAGGTAGA	0.527		NaN											0	0	0	0.003163	0	15	65									
YME1L1	10730	broad.mit.edu	37	10	27437904	27437904	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr10:27437904G>A	uc001iti.2	-	2	281	c.99C>T	c.(97-99)CTC>CTT	p.L33L	YME1L1_uc001itj.2_Silent_p.L33L|YME1L1_uc010qdl.1_Silent_p.L33L|YME1L1_uc009xkv.2_RNA|YME1L1_uc001itk.1_Silent_p.L33L	NM_139312	NP_647473	Q96TA2	YMEL1_HUMAN	YME1-like 1 isoform 1	33					protein catabolic process|proteolysis	membrane|mitochondrion	ATP binding|metal ion binding|metalloendopeptidase activity|nucleoside-triphosphatase activity			ovary(1)	1						ACACTCCACTGAGAGAAACAG	0.408		NaN											0	0	0	0.00361	0	49	199									
YME1L1	10730	broad.mit.edu	37	10	27437951	27437951	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr10:27437951G>A	uc001iti.2	-	2	234	c.52C>T	c.(52-54)CAT>TAT	p.H18Y	YME1L1_uc001itj.2_Missense_Mutation_p.H18Y|YME1L1_uc010qdl.1_Missense_Mutation_p.H18Y|YME1L1_uc009xkv.2_RNA|YME1L1_uc001itk.1_Missense_Mutation_p.H18Y	NM_139312	NP_647473	Q96TA2	YMEL1_HUMAN	YME1-like 1 isoform 1	18					protein catabolic process|proteolysis	membrane|mitochondrion	ATP binding|metal ion binding|metalloendopeptidase activity|nucleoside-triphosphatase activity			ovary(1)	1						TTGATGAGATGACTCAGAGGA	0.343		NaN											0	0	0	0.00361	0	33	157									
YME1L1	10730	broad.mit.edu	37	10	27437957	27437957	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr10:27437957G>A	uc001iti.2	-	2	228	c.46C>T	c.(46-48)CTG>TTG	p.L16L	YME1L1_uc001itj.2_Silent_p.L16L|YME1L1_uc010qdl.1_Silent_p.L16L|YME1L1_uc009xkv.2_RNA|YME1L1_uc001itk.1_Silent_p.L16L	NM_139312	NP_647473	Q96TA2	YMEL1_HUMAN	YME1-like 1 isoform 1	16					protein catabolic process|proteolysis	membrane|mitochondrion	ATP binding|metal ion binding|metalloendopeptidase activity|nucleoside-triphosphatase activity			ovary(1)	1						AGATGACTCAGAGGAACTGTA	0.338		NaN											0	0	0	0.006999	0	28	139									
WAC	51322	broad.mit.edu	37	10	28897142	28897142	+	Nonsense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr10:28897142C>G	uc001iuf.2	+	8	1032	c.947C>G	c.(946-948)TCA>TGA	p.S316*	WAC_uc001iud.2_Nonsense_Mutation_p.S271*|WAC_uc001iue.2_Intron|WAC_uc009xlb.2_Nonsense_Mutation_p.S271*|WAC_uc001iug.2_Nonsense_Mutation_p.S213*|WAC_uc001iuh.2_Nonsense_Mutation_p.S271*	NM_016628	NP_057712	Q9BTA9	WAC_HUMAN	WW domain-containing adapter with a coiled-coil	316					cell cycle checkpoint|histone H2B conserved C-terminal lysine ubiquitination|histone monoubiquitination|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nuclear speck	chromatin binding|RNA polymerase II core binding			large_intestine(1)|ovary(1)	2						AAACCCGTATCACATTCTTGC	0.433		NaN											0	0	0	0.00361	0	66	107									
PARD3	56288	broad.mit.edu	37	10	34805961	34805961	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr10:34805961G>A	uc010qej.1	-	3	349	c.349C>T	c.(349-351)CAG>TAG	p.Q117*	PARD3_uc010qek.1_Nonsense_Mutation_p.Q117*|PARD3_uc010qel.1_Nonsense_Mutation_p.Q117*|PARD3_uc010qem.1_Nonsense_Mutation_p.Q117*|PARD3_uc010qen.1_Nonsense_Mutation_p.Q117*|PARD3_uc010qeo.1_Nonsense_Mutation_p.Q117*|PARD3_uc010qep.1_Nonsense_Mutation_p.Q117*|PARD3_uc010qeq.1_Nonsense_Mutation_p.Q117*|PARD3_uc001ixp.1_5'UTR|PARD3_uc001ixq.1_Nonsense_Mutation_p.Q117*|PARD3_uc001ixr.1_Nonsense_Mutation_p.Q117*|PARD3_uc001ixt.1_5'UTR|PARD3_uc001ixu.1_Nonsense_Mutation_p.Q117*	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	117					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)				TGGTAAGGCTGAAAGGCTGAG	0.473		NaN											0	0	0	0.00361	0	46	78									
PCDH15	65217	broad.mit.edu	37	10	55569091	55569091	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr10:55569091G>A	uc010qhs.1	-	37	5129	c.4734C>T	c.(4732-4734)CGC>CGT	p.R1578R	PCDH15_uc010qhq.1_Intron|PCDH15_uc010qhr.1_Intron|PCDH15_uc010qht.1_Silent_p.R1571R|PCDH15_uc010qhu.1_3'UTR	NM_001142769	NP_001136241	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD2-1 precursor	Error:Variant_position_missing_in_Q96QU1_after_alignment					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				CTTCCTCAAGGCGTCTCTGCC	0.428		NaN								HNSCC(58;0.16)			0	0	0	0.010729	0	9	31									
DDX21	9188	broad.mit.edu	37	10	70733307	70733307	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr10:70733307G>C	uc001jov.1	+	10	1645	c.1555G>C	c.(1555-1557)GAG>CAG	p.E519Q	DDX21_uc001jow.1_Missense_Mutation_p.E451Q	NM_004728	NP_004719	Q9NR30	DDX21_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 21	519	Helicase C-terminal.					nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)	3						ATAGGATGTAGAGTCCTACAT	0.443		NaN											0	0	0	0.010771	0	35	22									
HKDC1	80201	broad.mit.edu	37	10	70992797	70992797	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr10:70992797G>T	uc001jpf.3	+	4	536	c.403G>T	c.(403-405)GCA>TCA	p.A135S	HKDC1_uc010qje.1_5'UTR	NM_025130	NP_079406	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	135					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			ovary(4)|skin(1)	5						TGACTGTCTGGCAGATTTCAT	0.468		NaN											1	0	7.93312e-07	0.00245	8.15589e-07	14	48									
COX15	1355	broad.mit.edu	37	10	101480768	101480768	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr10:101480768G>C	uc001kqb.3	-	6	1425	c.808C>G	c.(808-810)CTG>GTG	p.L270V	COX15_uc001kqc.3_Missense_Mutation_p.L270V|COX15_uc010qpj.1_Missense_Mutation_p.L91V	NM_078470	NP_510870	Q7KZN9	COX15_HUMAN	COX15 homolog isoform 1	270	Helical; (Potential).				heme a biosynthetic process|respiratory chain complex IV assembly|respiratory gaseous exchange	integral to membrane|mitochondrial respiratory chain	cytochrome-c oxidase activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;3.08e-10)|all cancers(201;2.43e-08)		AGGAACACCAGACCTGCTGTT	0.463		NaN											0	0	0	0.006214	0	7	13									
ABCC2	1244	broad.mit.edu	37	10	101567904	101567904	+	Missense_Mutation	SNP	A	A	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr10:101567904A>C	uc001kqf.2	+	13	1872	c.1733A>C	c.(1732-1734)AAG>ACG	p.K578T		NM_000392	NP_000383	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP),	578	ABC transmembrane type-1 1.|Extracellular (By similarity).					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GATGCACAAAAGGCCTTCACC	0.463		NaN											0	0	0	0.008871	0	20	107									
PNLIPRP1	5407	broad.mit.edu	37	10	118365052	118365052	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr10:118365052G>C	uc001lco.1	+	12	1345	c.1327G>C	c.(1327-1329)GAA>CAA	p.E443Q	PNLIPRP1_uc001lcp.2_Missense_Mutation_p.E443Q	NM_006229	NP_006220	P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1 precursor	443	PLAT.				lipid metabolic process		calcium ion binding|triglyceride lipase activity			ovary(1)|breast(1)	2				all cancers(201;0.0161)		GCAAAAGGGAGAAGAGAAGAC	0.403		NaN											0	0	0	0.00361	0	38	44									
SLC18A2	6571	broad.mit.edu	37	10	119014792	119014792	+	Silent	SNP	C	C	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr10:119014792C>A	uc001ldd.1	+	7	736	c.705C>A	c.(703-705)GGC>GGA	p.G235G	SLC18A2_uc009xyy.1_Silent_p.G32G	NM_003054	NP_003045	Q05940	VMAT2_HUMAN	solute carrier family 18 (vesicular monoamine),	235	Helical; (Potential).				neurotransmitter secretion	clathrin sculpted monoamine transport vesicle membrane|integral to plasma membrane|membrane fraction	monoamine transmembrane transporter activity				0		Colorectal(252;0.19)		all cancers(201;0.029)	Alseroxylon(DB00386)|Reserpine(DB00206)|Tetrabenazine(DB04844)	CTGCAGTGGGCCCCCCCTTCG	0.572		NaN											1	0	6.33695e-27	0.007835	6.8685e-27	33	66									
C10orf137	26098	broad.mit.edu	37	10	127413965	127413965	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr10:127413965G>C	uc001liq.1	+	5	882	c.589G>C	c.(589-591)GAG>CAG	p.E197Q	C10orf137_uc001lin.2_Missense_Mutation_p.E197Q|C10orf137_uc001lio.1_Missense_Mutation_p.E197Q|C10orf137_uc001lip.1_5'UTR	NM_015608	NP_056423	Q3B7T1	EDRF1_HUMAN	erythroid differentiation-related factor 1	197					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			ovary(5)|large_intestine(3)|lung(2)	10		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				AAAGAGCAAAGAGCACTGGTA	0.348		NaN											0	0	0	0.008291	0	8	21									
PTPRE	5791	broad.mit.edu	37	10	129877885	129877885	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr10:129877885G>T	uc001lkb.2	+	20	2233	c.1954G>T	c.(1954-1956)GCC>TCC	p.A652S	PTPRE_uc009yat.2_Missense_Mutation_p.A663S|PTPRE_uc009yau.2_Missense_Mutation_p.A652S|PTPRE_uc001lkd.2_Missense_Mutation_p.A594S|PTPRE_uc010quq.1_Intron	NM_006504	NP_006495	P23469	PTPRE_HUMAN	protein tyrosine phosphatase, receptor type, E	652	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				negative regulation of insulin receptor signaling pathway|protein phosphorylation	cytoplasm|integral to membrane|intermediate filament cytoskeleton|nucleus|plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(1)	1		all_epithelial(44;1.66e-05)|all_lung(145;0.00456)|Lung NSC(174;0.0066)|all_neural(114;0.0936)|Colorectal(57;0.141)|Breast(234;0.166)|Melanoma(40;0.203)				GCGAGTAAAAGCCGAGGGACT	0.458		NaN											1	0	0.004672	0.004672	0.00472216	3	40									
KNDC1	85442	broad.mit.edu	37	10	135038330	135038330	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr10:135038330C>G	uc001llz.1	+	30	5187	c.5186C>G	c.(5185-5187)TCC>TGC	p.S1729C		NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	1729					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		CACCAGGTCTCCAGCGAGAAG	0.577		NaN											0	0	0	0.011902	0	36	10									
MUC5B	727897	broad.mit.edu	37	11	1272679	1272679	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:1272679G>A	uc009ycr.1	+	52	15661	c.15535G>A	c.(15535-15537)GTG>ATG	p.V5179M	MUC5B_uc001ltb.2_Missense_Mutation_p.V4860M	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	4857	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		TATAGCCACCGTGATGGTGCC	0.632		NaN											0	0	0	0.004289	0	32	138									
OR52I1	390037	broad.mit.edu	37	11	4616239	4616239	+	Nonsense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:4616239C>G	uc010qyi.1	+	1	971	c.971C>G	c.(970-972)TCA>TGA	p.S324*		NM_001005169	NP_001005169	Q8NGK6	O52I1_HUMAN	olfactory receptor, family 52, subfamily I,	324	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;7.98e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		AACCTGGGTTCATGAACACAA	0.433		NaN											0	0	0	0.00632	0	24	89									
PIK3C2A	5286	broad.mit.edu	37	11	17172072	17172072	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:17172072G>A	uc001mmq.3	-	3	1366	c.1300C>T	c.(1300-1302)CAG>TAG	p.Q434*	PIK3C2A_uc009ygu.1_5'UTR|PIK3C2A_uc010rcw.1_Nonsense_Mutation_p.Q54*|PIK3C2A_uc001mmr.3_RNA|PIK3C2A_uc010rcx.1_Nonsense_Mutation_p.Q434*|PIK3C2A_uc009ygv.1_Nonsense_Mutation_p.Q434*	NM_002645	NP_002636	O00443	P3C2A_HUMAN	phosphoinositide-3-kinase, class 2 alpha	434					cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(4)|central_nervous_system(4)|stomach(1)|ovary(1)	10					Phosphatidylserine(DB00144)	ACTGGTAGCTGAAATCCTTCA	0.403		NaN											0	0	0	0.008361	0	25	102									
CCDC73	493860	broad.mit.edu	37	11	32705116	32705116	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:32705116G>C	uc001mtv.2	-	7	439	c.395C>G	c.(394-396)TCT>TGT	p.S132C	CCDC73_uc001mtw.1_Missense_Mutation_p.S132C|CCDC73_uc009yjt.2_Missense_Mutation_p.S132C	NM_001008391	NP_001008392	Q6ZRK6	CCD73_HUMAN	sarcoma antigen NY-SAR-79	132	Potential.									ovary(1)|central_nervous_system(1)	2	Breast(20;0.112)					AGAGTATTTAGAAACCTTGAA	0.328		NaN											0	0	0	0.004878	0	29	7									
AMBRA1	55626	broad.mit.edu	37	11	46529801	46529801	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:46529801G>C	uc010rgu.1	-	9	2639	c.2279C>G	c.(2278-2280)TCT>TGT	p.S760C	AMBRA1_uc010rgt.1_Missense_Mutation_p.S326C|AMBRA1_uc009ylc.1_Missense_Mutation_p.S731C|AMBRA1_uc001ncu.1_Missense_Mutation_p.S670C|AMBRA1_uc001ncv.2_Missense_Mutation_p.S763C|AMBRA1_uc001ncw.2_Missense_Mutation_p.S641C|AMBRA1_uc001ncx.2_Intron	NM_017749	NP_060219	Q9C0C7	AMRA1_HUMAN	activating molecule in beclin-1-regulated	760					autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				large_intestine(1)|ovary(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)		GTCTGAGGAAGAGGAGGAGGT	0.517		NaN											0	0	0	0.008361	0	24	67									
OR4A5	81318	broad.mit.edu	37	11	51412330	51412330	+	Silent	SNP	T	T	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:51412330T>C	uc001nhi.1	-	1	66	c.66A>G	c.(64-66)CAA>CAG	p.Q22Q		NM_001005272	NP_001005272	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A,	22	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(304;0.236)				ATAATGCTTTTTGCACACCAG	0.428		NaN											0	0	0	0.001368	0	10	35									
OR4D11	219986	broad.mit.edu	37	11	59271357	59271357	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:59271357C>T	uc001noa.1	+	1	309	c.309C>T	c.(307-309)CTC>CTT	p.L103L		NM_001004706	NP_001004706	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D,	103	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						AGATATTTCTCTTCCACCTCC	0.468		NaN											0	0	0	0.00361	0	109	59									
STX3	6809	broad.mit.edu	37	11	59560641	59560641	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:59560641C>T	uc001nog.2	+	7	726	c.536C>T	c.(535-537)TCT>TTT	p.S179F	STX3_uc010rkx.1_Missense_Mutation_p.S179F|STX3_uc010rky.1_Missense_Mutation_p.S82F|STX3_uc009ymt.1_Missense_Mutation_p.S82F	NM_004177	NP_004168	Q13277	STX3_HUMAN	syntaxin 3	179	Cytoplasmic (Potential).				cellular response to oxidative stress|intracellular protein transport|neuron projection development|neurotransmitter transport	apical plasma membrane|azurophil granule|cell-cell junction|growth cone|integral to membrane|plasma membrane enriched fraction|SNARE complex|specific granule	arachidonic acid binding|SNAP receptor activity			ovary(2)	2						ATCTTCACTTCTGGGGTGAGT	0.562		NaN											0	0	0	0.002299	0	20	14									
TMEM132A	54972	broad.mit.edu	37	11	60702234	60702234	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:60702234G>A	uc001nqj.2	+	9	2027	c.1834G>A	c.(1834-1836)GAG>AAG	p.E612K	TMEM132A_uc001nqi.2_Missense_Mutation_p.E613K|TMEM132A_uc001nqm.2_5'UTR	NM_178031	NP_821174	Q24JP5	T132A_HUMAN	transmembrane protein 132A isoform b	612	Binds to HSPA5/GRP78 (By similarity).|Extracellular (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				skin(1)	1						CACCTCCATTGAGGTAAGCAG	0.667		NaN											0	0	0	0.006999	0	34	19									
AHNAK	79026	broad.mit.edu	37	11	62293224	62293224	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:62293224C>G	uc001ntl.2	-	5	8965	c.8665G>C	c.(8665-8667)GAC>CAC	p.D2889H	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2889					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				AGGTGCCAGTCTGGACCCTGA	0.517		NaN											0	0	0	0.00361	0	74	257									
AHNAK	79026	broad.mit.edu	37	11	62293741	62293741	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:62293741C>T	uc001ntl.2	-	5	8448	c.8148G>A	c.(8146-8148)CTG>CTA	p.L2716L	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2716					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TGGGTCCTTTCAGGTTTAAGT	0.473		NaN											0	0	0	0.00361	0	58	181									
AHNAK	79026	broad.mit.edu	37	11	62293851	62293851	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:62293851C>G	uc001ntl.2	-	5	8338	c.8038G>C	c.(8038-8040)GAT>CAT	p.D2680H	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2680					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				ATGTTAACATCAGGGCCTTCA	0.498		NaN											0	0	0	0.00361	0	53	159									
AHNAK	79026	broad.mit.edu	37	11	62295310	62295310	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:62295310C>G	uc001ntl.2	-	5	6879	c.6579G>C	c.(6577-6579)TTG>TTC	p.L2193F	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2193					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TGGGGCCTTTCAAGTTTAAGT	0.473		NaN											0	0	0	0.00361	0	106	352									
EEF1G	1937	broad.mit.edu	37	11	62327634	62327634	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:62327634C>G	uc001ntm.1	-	9	1208	c.1062G>C	c.(1060-1062)AAG>AAC	p.K354N	EEF1G_uc010rlw.1_Missense_Mutation_p.K404N|EEF1G_uc001ntn.1_Missense_Mutation_p.K234N	NM_001404	NP_001395	P26641	EF1G_HUMAN	eukaryotic translation elongation factor 1	354	EF-1-gamma C-terminal.				response to virus	cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity				0						CGAAGGCATTCTTCCTCAGCT	0.517		NaN											0	0	0	0.011902	0	45	19									
COX8A	1351	broad.mit.edu	37	11	63742235	63742235	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:63742235C>G	uc001nye.2	+	1	157	c.83C>G	c.(82-84)TCG>TGG	p.S28W		NM_004074	NP_004065	P10176	COX8A_HUMAN	cytochrome c oxidase subunit VIIIa precursor	28	Mitochondrial matrix (By similarity).				respiratory electron transport chain	integral to membrane|mitochondrial inner membrane	cytochrome-c oxidase activity				0						AAGATCCATTCGTTGCCGCCG	0.687		NaN											0	0	0	0.001368	0	12	20									
CTTN	2017	broad.mit.edu	37	11	70281143	70281143	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:70281143G>A	uc001opv.3	+	18	1734	c.1528G>A	c.(1528-1530)GAG>AAG	p.E510K	CTTN_uc001opu.2_Missense_Mutation_p.E473K|CTTN_uc001opw.3_Missense_Mutation_p.E473K|CTTN_uc010rqm.1_Missense_Mutation_p.E194K|CTTN_uc001opx.2_Missense_Mutation_p.E194K	NM_005231	NP_005222	Q14247	SRC8_HUMAN	cortactin isoform a	510	SH3.					cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)		GGGCGATGATGAGATCTCATT	0.557		NaN											0	0	0	0.00361	0	42	145									
TSKU	25987	broad.mit.edu	37	11	76506762	76506762	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:76506762C>T	uc001oxt.2	+	2	274	c.102C>T	c.(100-102)TTC>TTT	p.F34F		NM_015516	NP_056331	Q8WUA8	TSK_HUMAN	tsukushin precursor	34	LRRNT.					extracellular region					0	Ovarian(111;0.112)					TCGGCCTTTTCGACAGCTTCA	0.662		NaN											0	0	0	0.003271	0	32	87									
TSKU	25987	broad.mit.edu	37	11	76507100	76507100	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:76507100C>T	uc001oxt.2	+	2	612	c.440C>T	c.(439-441)TCA>TTA	p.S147L		NM_015516	NP_056331	Q8WUA8	TSK_HUMAN	tsukushin precursor	147	LRR 4.					extracellular region					0	Ovarian(111;0.112)					CGGGAGGTCTCAGTGTCTGCC	0.652		NaN											0	0	0	0.007291	0	27	117									
ODZ4	26011	broad.mit.edu	37	11	78381538	78381538	+	Missense_Mutation	SNP	T	T	C	rs76161186		TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:78381538T>C	uc001ozl.3	-	32	6315	c.5852A>G	c.(5851-5853)GAC>GGC	p.D1951G	ODZ4_uc001ozk.3_Missense_Mutation_p.D176G|ODZ4_uc009yvb.1_Missense_Mutation_p.D535G	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	1951	YD 7.|Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						AGAGAGGCGGTCATTCTTGTC	0.547		NaN											0	0	0	0.001984	0	6	122									
FOLH1B	219595	broad.mit.edu	37	11	89424091	89424091	+	Silent	SNP	C	C	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:89424091C>A	uc001pda.2	+	11	1267	c.741C>A	c.(739-741)GTC>GTA	p.V247V		NM_153696	NP_710163	Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B	247					proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			ovary(3)|skin(2)|central_nervous_system(1)	6						ATCACAGTGTCTATGAAACAT	0.373		NaN											1	0	0.00307968	0.00308	0.00312232	5	44									
USP28	57646	broad.mit.edu	37	11	113694393	113694393	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:113694393C>T	uc001poh.2	-	12	1250	c.1217G>A	c.(1216-1218)CGA>CAA	p.R406Q	USP28_uc001pog.2_Missense_Mutation_p.R114Q|USP28_uc010rwy.1_Missense_Mutation_p.R281Q|USP28_uc001poi.2_5'UTR|USP28_uc001poj.3_Missense_Mutation_p.R406Q	NM_020886	NP_065937	Q96RU2	UBP28_HUMAN	ubiquitin specific protease 28	406					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|breast(2)|ovary(1)|large_intestine(1)|kidney(1)	7		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		TCTCTTATTTCGAATAAGCTC	0.284		NaN											0	0	0	0.00245	0	11	4									
SIAE	54414	broad.mit.edu	37	11	124518069	124518069	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:124518069G>A	uc001qan.2	-	6	838	c.725C>T	c.(724-726)TCC>TTC	p.S242F		NM_170601	NP_733746	Q9HAT2	SIAE_HUMAN	sialate O-acetylesterase precursor	242						extracellular region|lysosome	carboxylesterase activity|sialate O-acetylesterase activity				0	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0243)		GTATGGAATGGACCTGAAATC	0.443		NaN											0	0	0	0.003954	0	23	25									
ARHGAP32	9743	broad.mit.edu	37	11	128936700	128936700	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:128936700G>C	uc009zcp.2	-	6	553	c.553C>G	c.(553-555)CTG>GTG	p.L185V	ARHGAP32_uc009zcq.1_Missense_Mutation_p.L145V|ARHGAP32_uc001qfb.2_Translation_Start_Site	NM_001142685	NP_001136157	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 1	185	PX; atypical.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5						TAAATACACAGATGAAGATGT	0.373		NaN											0	0	0	0.000602	0	5	28									
ADAMTS8	11095	broad.mit.edu	37	11	130275534	130275534	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:130275534G>A	uc001qgg.3	-	9	2947	c.2589C>T	c.(2587-2589)TCC>TCT	p.S863S	ADAMTS8_uc001qgf.2_Silent_p.S344S	NM_007037	NP_008968	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1	863	TSP type-1 2.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)	1	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		AGGCCTGGCCGGAGGGGTCCC	0.672		NaN											0	0	0	0.009096	0	3	68									
SNX19	399979	broad.mit.edu	37	11	130785702	130785702	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:130785702G>C	uc001qgk.3	-	1	681	c.133C>G	c.(133-135)CTG>GTG	p.L45V	SNX19_uc010sce.1_Intron|SNX19_uc010scf.1_Intron|SNX19_uc010scg.1_Intron|SNX19_uc001qgl.3_Missense_Mutation_p.L45V|SNX19_uc009zcx.1_Intron	NM_014758	NP_055573	Q92543	SNX19_HUMAN	sorting nexin 19	45					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			ovary(2)|lung(2)	4	all_hematologic(175;0.0597)	Lung NSC(97;0.000272)|all_lung(97;0.000608)|Breast(109;0.000962)|all_neural(223;0.0298)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;0.0195)|Lung(977;0.233)		ACGTTGACCAGAAGGTGTATG	0.587		NaN											0	0	0	0.002299	0	20	71									
VPS26B	112936	broad.mit.edu	37	11	134113161	134113161	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:134113161G>C	uc001qhe.2	+	4	1150	c.694G>C	c.(694-696)GAG>CAG	p.E232Q		NM_052875	NP_443107	Q4G0F5	VP26B_HUMAN	vacuolar protein sorting 26 homolog B	232					protein transport|vacuolar transport	cytosol|retromer complex					0	all_hematologic(175;0.127)	all_cancers(12;1.1e-21)|all_epithelial(12;3.77e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;2.43e-10)|all cancers(11;2.94e-09)|BRCA - Breast invasive adenocarcinoma(10;9.57e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00164)|Lung(977;0.216)		AGCCAAGTACGAGATCATGGA	0.537		NaN											0	0	0	0.006214	0	9	22									
ENO2	2026	broad.mit.edu	37	12	7031509	7031509	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:7031509C>G	uc001qru.1	+	11	1401	c.1179C>G	c.(1177-1179)ATC>ATG	p.I393M	ENO2_uc009zfi.1_Missense_Mutation_p.I393M|ENO2_uc010sfq.1_Missense_Mutation_p.I350M|ENO2_uc001qrv.1_Missense_Mutation_p.I393M|ATN1_uc001qrw.1_5'Flank	NM_001975	NP_001966	P09104	ENOG_HUMAN	enolase 2	393					gluconeogenesis|glycolysis	phosphopyruvate hydratase complex|plasma membrane	magnesium ion binding|phosphopyruvate hydratase activity				0						TGTTTCAGATCAAGACTGGTG	0.547		NaN											0	0	0	0.013114	0	38	62									
DDX47	51202	broad.mit.edu	37	12	12978977	12978977	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:12978977C>G	uc001rav.2	+	13	1677	c.1079C>G	c.(1078-1080)TCC>TGC	p.S360C	DDX47_uc001rax.2_Missense_Mutation_p.S360C|DDX47_uc001ray.2_Missense_Mutation_p.S311C	NM_016355	NP_057439	Q9H0S4	DDX47_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 47	360	Helicase C-terminal.					nucleolus|nucleolus	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding				0		Prostate(47;0.0526)		BRCA - Breast invasive adenocarcinoma(232;0.0354)		GCTGGGCGCTCCGGAAAGGCT	0.254		NaN											0	0	0	0.000602	0	5	47									
DDX47	51202	broad.mit.edu	37	12	12980212	12980212	+	Missense_Mutation	SNP	A	A	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:12980212A>T	uc001rav.2	+	14	1737	c.1139A>T	c.(1138-1140)CAC>CTC	p.H380L	DDX47_uc001rax.2_Missense_Mutation_p.H380L|DDX47_uc001ray.2_Missense_Mutation_p.H331L	NM_016355	NP_057439	Q9H0S4	DDX47_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 47	380	Helicase C-terminal.					nucleolus|nucleolus	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding				0		Prostate(47;0.0526)		BRCA - Breast invasive adenocarcinoma(232;0.0354)		CGCATAGAACACTTAATTGGG	0.473		NaN											0	0	0	0.003755	0	35	111									
GSG1	83445	broad.mit.edu	37	12	13243611	13243611	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:13243611C>T	uc001rbn.2	-	2	363	c.190G>A	c.(190-192)GAG>AAG	p.E64K	GSG1_uc001rbj.2_Missense_Mutation_p.E51K|GSG1_uc001rbk.2_Missense_Mutation_p.E51K|GSG1_uc001rbl.2_Missense_Mutation_p.E51K|GSG1_uc001rbm.2_Missense_Mutation_p.E51K|GSG1_uc001rbo.2_Missense_Mutation_p.E64K|GSG1_uc001rbp.2_Missense_Mutation_p.E64K|GSG1_uc001rbq.1_Missense_Mutation_p.E64K	NM_001080555	NP_001074024	Q2KHT4	GSG1_HUMAN	germ cell associated 1 isoform 4	51						endoplasmic reticulum membrane|integral to membrane					0		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.15)		AGACCTTTCTCGCACAGGGGC	0.542		NaN											0	0	0	0.00361	0	56	95									
PDE3A	5139	broad.mit.edu	37	12	20803462	20803462	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:20803462C>G	uc001reh.1	+	14	2875	c.2853C>G	c.(2851-2853)ATC>ATG	p.I951M		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	951	Catalytic (By similarity).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	TGGCTGATATCAATGGTCCAG	0.348		NaN											0	0	0	0.003271	0	32	31									
ST8SIA1	6489	broad.mit.edu	37	12	22408294	22408294	+	Missense_Mutation	SNP	T	T	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:22408294T>A	uc001rfo.3	-	3	893	c.411A>T	c.(409-411)AAA>AAT	p.K137N	ST8SIA1_uc009zix.2_Intron	NM_003034	NP_003025	Q92185	SIA8A_HUMAN	alpha-2,8-sialyltransferase 1	137	Lumenal (Potential).				glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			ovary(3)	3						CCACCGCGCATTTCTTCAATG	0.478		NaN											0	0	0	0.00361	0	108	107									
BCAT1	586	broad.mit.edu	37	12	25031487	25031487	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:25031487G>A	uc001rgd.3	-	5	929	c.487C>T	c.(487-489)CGT>TGT	p.R163C	BCAT1_uc001rgc.2_Missense_Mutation_p.R162C|BCAT1_uc010six.1_Missense_Mutation_p.R175C|BCAT1_uc010siy.1_Missense_Mutation_p.R126C|BCAT1_uc001rge.3_Missense_Mutation_p.R102C	NM_005504	NP_005495	P54687	BCAT1_HUMAN	branched chain aminotransferase 1, cytosolic	163					branched chain family amino acid biosynthetic process|branched chain family amino acid catabolic process|cell proliferation|G1/S transition of mitotic cell cycle	cytosol	L-isoleucine transaminase activity|L-leucine transaminase activity|L-valine transaminase activity			lung(1)|breast(1)	2	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Ovarian(17;0.107)|Colorectal(261;0.196)				Gabapentin(DB00996)|L-Glutamic Acid(DB00142)|L-Isoleucine(DB00167)|L-Leucine(DB00149)|L-Valine(DB00161)|Pyridoxal Phosphate(DB00114)	AATGTAGGACGAATATACAGA	0.373		NaN											0	0	0	0.008361	0	23	26									
MLL2	8085	broad.mit.edu	37	12	49447270	49447270	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:49447270G>A	uc001rta.3	-	6	828	c.828C>T	c.(826-828)TGC>TGT	p.C276C		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	276	PHD-type 2.|PHD-type 1.|RING-type 2; degenerate.|Cys-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TGCAGGCTTGGCACACTTTGC	0.557		NaN	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.00308	0	6	16									
BCDIN3D	144233	broad.mit.edu	37	12	50232675	50232675	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:50232675C>T	uc001rvh.2	-	2	400	c.358G>A	c.(358-360)GAA>AAA	p.E120K	LOC100286844_uc010smm.1_Intron|LOC100286844_uc001rvg.2_RNA|LOC100286844_uc010smn.1_RNA	NM_181708	NP_859059	Q7Z5W3	BN3D2_HUMAN	BCDIN3 domain containing	120	Bin3-type SAM.						methyltransferase activity			ovary(1)	1						CATTCTTTTTCGGCTCGCTTC	0.488		NaN									OREG0021805	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010504	0	17	50									
DIP2B	57609	broad.mit.edu	37	12	51117053	51117053	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:51117053C>G	uc001rwv.2	+	27	3391	c.3235C>G	c.(3235-3237)CCA>GCA	p.P1079A	DIP2B_uc009zlt.2_Missense_Mutation_p.P509A	NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B	1079						nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6						CGTCAGACCTCCACATGCTCA	0.522		NaN											0	0	0	0.013114	0	36	98									
DIP2B	57609	broad.mit.edu	37	12	51118560	51118560	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:51118560C>T	uc001rwv.2	+	28	3447	c.3291C>T	c.(3289-3291)GTC>GTT	p.V1097V	DIP2B_uc009zlt.2_Silent_p.V527V	NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B	1097						nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6						TTTTCTAGGTCAGCAAAGCAG	0.532		NaN											0	0	0	0.00245	0	8	53									
DIP2B	57609	broad.mit.edu	37	12	51121551	51121551	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:51121551C>G	uc001rwv.2	+	29	3622	c.3466C>G	c.(3466-3468)CTT>GTT	p.L1156V	DIP2B_uc009zlt.2_Missense_Mutation_p.L586V	NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B	1156						nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6						GTTGGCATATCTTGATTTTAG	0.433		NaN											0	0	0	0.00361	0	42	114									
METTL7A	25840	broad.mit.edu	37	12	51319290	51319290	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:51319290C>T	uc001rxb.2	+	1	757	c.469C>T	c.(469-471)CTC>TTC	p.L157F	METTL7A_uc010smv.1_Intron	NM_014033	NP_054752	Q9H8H3	MET7A_HUMAN	methyltransferase like 7A precursor	157						endoplasmic reticulum|lipid particle|membrane	methyltransferase activity				0						GGAGCGGATTCTCCGCGAGGT	0.562		NaN											0	0	0	0.007413	0	18	36									
POU6F1	5463	broad.mit.edu	37	12	51585471	51585471	+	Silent	SNP	G	G	A	rs150600315	byFrequency	TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:51585471G>A	uc001rxy.2	-	4	660	c.468C>T	c.(466-468)ATC>ATT	p.I156I	POU6F1_uc001rxz.2_Silent_p.I156I|POU6F1_uc001rya.2_Silent_p.I156I	NM_002702	NP_002693	Q14863	PO6F1_HUMAN	POU class 6 homeobox 1	156	POU-specific.				brain development|heart development|muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1						AGAGCCGCCGGATCTTAAAGT	0.572		NaN											0	0	0	0.00361	0	43	93									
POU6F1	5463	broad.mit.edu	37	12	51585498	51585498	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:51585498G>C	uc001rxy.2	-	4	633	c.441C>G	c.(439-441)ATC>ATG	p.I147M	POU6F1_uc001rxz.2_Missense_Mutation_p.I147M|POU6F1_uc001rya.2_Missense_Mutation_p.I147M	NM_002702	NP_002693	Q14863	PO6F1_HUMAN	POU class 6 homeobox 1	147	POU-specific.				brain development|heart development|muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1						CAAACTCCCGGATCTCTTCTA	0.557		NaN											0	0	0	0.00361	0	52	118									
POU6F1	5463	broad.mit.edu	37	12	51586129	51586129	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:51586129G>A	uc001rxy.2	-	3	567	c.375C>T	c.(373-375)GTC>GTT	p.V125V	POU6F1_uc001rxz.2_Silent_p.V125V|POU6F1_uc001rya.2_Silent_p.V125V	NM_002702	NP_002693	Q14863	PO6F1_HUMAN	POU class 6 homeobox 1	125	Gln/Pro-rich.				brain development|heart development|muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1						CCAACTGGCTGACGGTGGGGG	0.582		NaN											0	0	0	0.00361	0	52	176									
POU6F1	5463	broad.mit.edu	37	12	51586207	51586207	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:51586207G>A	uc001rxy.2	-	3	489	c.297C>T	c.(295-297)GTC>GTT	p.V99V	POU6F1_uc001rxz.2_Silent_p.V99V|POU6F1_uc001rya.2_Silent_p.V99V	NM_002702	NP_002693	Q14863	PO6F1_HUMAN	POU class 6 homeobox 1	99	Gln/Pro-rich.				brain development|heart development|muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1						GGCTGGCAATGACCACAGCAG	0.607		NaN											0	0	0	0.00361	0	50	147									
KRT18	3875	broad.mit.edu	37	12	53345344	53345344	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:53345344C>A	uc001sbe.2	+	5	806	c.737C>A	c.(736-738)GCC>GAC	p.A246D	KRT18_uc009zmn.1_Missense_Mutation_p.A246D|KRT18_uc001sbf.1_Missense_Mutation_p.A73D|KRT18_uc001sbg.2_Missense_Mutation_p.A246D|KRT18_uc009zmo.2_Missense_Mutation_p.A246D|KRT8_uc009zml.1_5'Flank|KRT8_uc009zmm.1_5'Flank	NM_199187	NP_954657	P05783	K1C18_HUMAN	keratin 18	246	Interaction with DNAJB6.|Linker 12.|Rod.|Necessary for interaction with PNN.			A -> S (in Ref. 8; CAA31369).	anatomical structure morphogenesis|cell cycle|Golgi to plasma membrane CFTR protein transport|interspecies interaction between organisms|negative regulation of apoptosis	centriolar satellite|keratin filament|perinuclear region of cytoplasm	protein binding|structural molecule activity			skin(1)	1						CAGGACCTCGCCAAGATCATG	0.562		NaN											1	0	7.93312e-07	0.00245	8.15589e-07	12	30									
RARG	5916	broad.mit.edu	37	12	53607440	53607440	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:53607440C>G	uc001sce.2	-	8	1343	c.858G>C	c.(856-858)ATG>ATC	p.M286I	RARG_uc001scd.2_Missense_Mutation_p.M275I|RARG_uc010sob.1_Missense_Mutation_p.M264I|RARG_uc001scf.2_Missense_Mutation_p.M286I|RARG_uc001scg.2_Missense_Mutation_p.M214I|RARG_uc010soc.1_Missense_Mutation_p.M165I|RARG_uc010sod.1_Missense_Mutation_p.M323I	NM_000966	NP_000957	P13631	RARG_HUMAN	retinoic acid receptor, gamma isoform 1	286	Ligand-binding.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|ovary(1)|lung(1)	4					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	CGGAGAAGGTCATGGTGTCCT	0.607		NaN									OREG0021862	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00361	0	91	65									
RARG	5916	broad.mit.edu	37	12	53607956	53607956	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:53607956C>G	uc001sce.2	-	7	1185	c.700G>C	c.(700-702)GCT>CCT	p.A234P	RARG_uc001scd.2_Missense_Mutation_p.A223P|RARG_uc010sob.1_Missense_Mutation_p.A212P|RARG_uc001scf.2_Missense_Mutation_p.A234P|RARG_uc001scg.2_Missense_Mutation_p.A162P|RARG_uc010soc.1_Missense_Mutation_p.A113P|RARG_uc010sod.1_Missense_Mutation_p.A271P	NM_000966	NP_000957	P13631	RARG_HUMAN	retinoic acid receptor, gamma isoform 1	234	Ligand-binding.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|ovary(1)|lung(1)	4					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	CACTTGGTAGCCAGCTCACTG	0.567		NaN											0	0	0	0.010771	0	41	113									
HOXC9	3225	broad.mit.edu	37	12	54394234	54394234	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:54394234G>A	uc001sep.2	+	2	360	c.262G>A	c.(262-264)GCC>ACC	p.A88T	HOXC9_uc001seq.2_Missense_Mutation_p.A88T	NM_006897	NP_008828	P31274	HXC9_HUMAN	homeobox C9	88					multicellular organismal development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|pancreas(1)|skin(1)	3						CCACCTCGGCGCCGACACGCG	0.711		NaN											0	0	0	0.007835	0	33	19									
NFE2	4778	broad.mit.edu	37	12	54686942	54686942	+	Nonsense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:54686942G>C	uc009znk.2	-	2	848	c.338C>G	c.(337-339)TCA>TGA	p.S113*	NFE2_uc001sfq.2_Nonsense_Mutation_p.S113*|NFE2_uc001sfr.3_Nonsense_Mutation_p.S113*|NFE2_uc009znl.2_Nonsense_Mutation_p.S113*	NM_006163	NP_006154	Q16621	NFE2_HUMAN	nuclear factor, erythroid derived 2 isoform 1	113	Transactivation domain.				blood circulation|blood coagulation|multicellular organismal development|nucleosome disassembly|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	actin cytoskeleton|cytoplasm|PML body	protein dimerization activity|protein N-terminus binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|WW domain binding				0						GAGCAGGCCTGAGAGGCTCAG	0.592		NaN											0	0	0	0.00361	0	44	108									
SMARCC2	6601	broad.mit.edu	37	12	56572315	56572315	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:56572315C>G	uc001skb.2	-	14	1289	c.1183G>C	c.(1183-1185)GAG>CAG	p.E395Q	SMARCC2_uc001skd.2_Missense_Mutation_p.E395Q|SMARCC2_uc001ska.2_Missense_Mutation_p.E395Q|SMARCC2_uc001skc.2_Missense_Mutation_p.E395Q|SMARCC2_uc010sqf.1_Missense_Mutation_p.E284Q	NM_003075	NP_003066	Q8TAQ2	SMRC2_HUMAN	SWI/SNF-related matrix-associated	395					chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			lung(2)|central_nervous_system(2)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(18;0.123)			TTCTCATCCTCATCCTACGAG	0.527		NaN											0	0	0	0.00361	0	77	45									
CAND1	55832	broad.mit.edu	37	12	67700122	67700122	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:67700122C>G	uc001stn.2	+	10	3111	c.2674C>G	c.(2674-2676)CTG>GTG	p.L892V	CAND1_uc001sto.2_Missense_Mutation_p.L402V	NM_018448	NP_060918	Q86VP6	CAND1_HUMAN	TIP120 protein	892	HEAT 21.				cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)		TCCTGAATATCTGCCGTTTGT	0.418		NaN											0	0	0	0.007413	0	15	113									
STAB2	55576	broad.mit.edu	37	12	104123937	104123937	+	Missense_Mutation	SNP	A	A	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:104123937A>C	uc001tjw.2	+	49	5312	c.5126A>C	c.(5125-5127)GAT>GCT	p.D1709A	STAB2_uc009zug.2_RNA	NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	1709	Extracellular (Potential).|FAS1 5.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						ATATCCAGTGATATCATCAGT	0.333		NaN											0	0	0	0.012213	0	27	42									
COX6A1	1337	broad.mit.edu	37	12	120875952	120875952	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:120875952C>T	uc001tyf.1	+	1	49	c.23C>T	c.(22-24)TCG>TTG	p.S8L		NM_004373	NP_004364	P12074	CX6A1_HUMAN	cytochrome c oxidase subunit VIa polypeptide 1	8					respiratory electron transport chain	mitochondrial respiratory chain complex IV	cytochrome-c oxidase activity				0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGTGTGTCCTCGGTTTCTCGG	0.637		NaN											0	0	0	0.003954	0	21	6									
HIP1R	9026	broad.mit.edu	37	12	123338615	123338615	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:123338615C>T	uc001udj.1	+	8	662	c.603C>T	c.(601-603)ATC>ATT	p.I201I	HIP1R_uc001udg.1_Silent_p.I189I|HIP1R_uc001udi.1_Silent_p.I201I	NM_003959	NP_003950	O75146	HIP1R_HUMAN	huntingtin interacting protein-1-related	201					receptor-mediated endocytosis	clathrin coated vesicle membrane|coated pit|perinuclear region of cytoplasm	actin binding|phosphatidylinositol binding			ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;4.6e-05)|Epithelial(86;0.000119)|BRCA - Breast invasive adenocarcinoma(302;0.2)		ACACGGCCATCGCCGTATCCC	0.602		NaN											0	0	0	0.00361	0	88	246									
EP400	57634	broad.mit.edu	37	12	132547196	132547196	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:132547196G>A	uc001ujn.2	+	46	8319	c.8284G>A	c.(8284-8286)GGC>AGC	p.G2762S	EP400_uc001ujl.2_Missense_Mutation_p.G2761S|EP400_uc001ujm.2_Missense_Mutation_p.G2681S|EP400_uc001ujp.2_5'UTR	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	2798					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		ACAGATCCAGGGCCAGGCCCA	0.418		NaN											0	0	0	0.00361	0	51	48									
ZDHHC20	253832	broad.mit.edu	37	13	21955650	21955650	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr13:21955650C>T	uc001uob.2	-	11	1093	c.980G>A	c.(979-981)AGT>AAT	p.S327N	ZDHHC20_uc001uod.2_RNA|ZDHHC20_uc001uoc.2_RNA|ZDHHC20_uc001uoe.2_RNA|ZDHHC20_uc010tcs.1_Missense_Mutation_p.S265N	NM_153251	NP_694983	Q5W0Z9	ZDH20_HUMAN	zinc finger, DHHC-type containing 20	328						integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)	1		all_cancers(29;8.1e-16)|all_epithelial(30;3.63e-14)|all_lung(29;2.04e-13)|Lung SC(185;0.0367)		all cancers(112;0.000268)|Epithelial(112;0.000735)|OV - Ovarian serous cystadenocarcinoma(117;0.00517)|Lung(94;0.171)		TTTTGATTCACTAAGTGGTTT	0.378		NaN											0	0	0	0.009718	0	35	14									
ATP12A	479	broad.mit.edu	37	13	25274960	25274960	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr13:25274960C>T	uc001upp.2	+	13	1968	c.1781C>T	c.(1780-1782)CCG>CTG	p.P594L	ATP12A_uc010aaa.2_Missense_Mutation_p.P600L	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	594	Cytoplasmic (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	ATGAACTTTCCGACCTCCAAC	0.488		NaN											0	0	0	0.00361	0	61	28									
PABPC3	5042	broad.mit.edu	37	13	25671754	25671754	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr13:25671754C>T	uc001upy.2	+	1	1479	c.1418C>T	c.(1417-1419)ACG>ATG	p.T473M		NM_030979	NP_112241	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	473					mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			ovary(3)|skin(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		GTCATGTCAACGCAGCGTGTT	0.423		NaN											0	0	0	0.00278	0	20	88									
RNF6	6049	broad.mit.edu	37	13	26788716	26788716	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr13:26788716C>T	uc001uqo.2	-	5	1594	c.1303G>A	c.(1303-1305)GAA>AAA	p.E435K	RNF6_uc001uqn.1_Intron|RNF6_uc010aak.2_Missense_Mutation_p.E435K|RNF6_uc001uqp.2_Missense_Mutation_p.E435K|RNF6_uc001uqq.2_Missense_Mutation_p.E435K|RNF6_uc010tdk.1_Missense_Mutation_p.E79K	NM_183044	NP_898865	Q9Y252	RNF6_HUMAN	ring finger protein 6	435					negative regulation of axon extension|positive regulation of transcription, DNA-dependent|protein K27-linked ubiquitination|protein K48-linked ubiquitination|protein K6-linked ubiquitination|regulation of androgen receptor signaling pathway|ubiquitin-dependent protein catabolic process	axon|cytoplasm|PML body	androgen receptor binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|skin(1)	2	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.00893)|Epithelial(112;0.0481)|OV - Ovarian serous cystadenocarcinoma(117;0.148)|GBM - Glioblastoma multiforme(144;0.23)|Lung(94;0.245)		CTATTGCTTTCAATAGTGACT	0.438		NaN											0	0	0	0.00361	0	39	126									
BRCA2	675	broad.mit.edu	37	13	32911868	32911868	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr13:32911868G>C	uc001uub.1	+	11	3603	c.3376G>C	c.(3376-3378)GAA>CAA	p.E1126Q		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1126					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		AAGTCAGTTTGAATTTACTCA	0.343		NaN	D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			0	0	0	0.003163	0	15	28									
BRCA2	675	broad.mit.edu	37	13	32912648	32912648	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr13:32912648G>T	uc001uub.1	+	11	4383	c.4156G>T	c.(4156-4158)GAT>TAT	p.D1386Y		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1386					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		AGATTTGTCAGATTTAACTTT	0.338		NaN	D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			1	0	0.00136819	0.001368	0.00139357	10	36									
BRCA2	675	broad.mit.edu	37	13	32913201	32913201	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr13:32913201G>C	uc001uub.1	+	11	4936	c.4709G>C	c.(4708-4710)AGA>ACA	p.R1570T		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1570					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		CTAAAGTACAGAGAGGCCTGT	0.383		NaN	D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			0	0	0	0.008871	0	16	86									
BRCA2	675	broad.mit.edu	37	13	32914175	32914175	+	Missense_Mutation	SNP	G	G	A	rs146351301	by1000genomes	TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr13:32914175G>A	uc001uub.1	+	11	5910	c.5683G>A	c.(5683-5685)GAG>AAG	p.E1895K		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1895					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		AGGTTGTTACGAGGCATTGGA	0.338		NaN	D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			0	0	0	0.008291	0	10	48									
BRCA2	675	broad.mit.edu	37	13	32914223	32914223	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr13:32914223G>A	uc001uub.1	+	11	5958	c.5731G>A	c.(5731-5733)GAT>AAT	p.D1911N		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1911					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		TCTAGATAATGATGAATGTAG	0.338		NaN	D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			0	0	0	0.001368	0	11	38									
SCEL	8796	broad.mit.edu	37	13	78163292	78163292	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr13:78163292C>T	uc001vki.2	+	10	729	c.559C>T	c.(559-561)CAC>TAC	p.H187Y	SCEL_uc001vkj.2_Missense_Mutation_p.H187Y|SCEL_uc010thx.1_Missense_Mutation_p.H165Y	NM_144777	NP_659001	O95171	SCEL_HUMAN	sciellin isoform 1	187					embryo development|keratinocyte differentiation	cornified envelope|cytoplasm|membrane	protein binding|zinc ion binding			ovary(4)|breast(1)	5		Acute lymphoblastic leukemia(28;0.0282)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0233)		ACCAGGTGTTCACCCTCCAAT	0.393		NaN											0	0	0	0.006122	0	14	70									
SCEL	8796	broad.mit.edu	37	13	78163298	78163298	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr13:78163298C>T	uc001vki.2	+	10	735	c.565C>T	c.(565-567)CCA>TCA	p.P189S	SCEL_uc001vkj.2_Missense_Mutation_p.P189S|SCEL_uc010thx.1_Missense_Mutation_p.P167S	NM_144777	NP_659001	O95171	SCEL_HUMAN	sciellin isoform 1	189					embryo development|keratinocyte differentiation	cornified envelope|cytoplasm|membrane	protein binding|zinc ion binding			ovary(4)|breast(1)	5		Acute lymphoblastic leukemia(28;0.0282)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0233)		TGTTCACCCTCCAATACCTCC	0.393		NaN											0	0	0	0.008871	0	15	75									
DZIP1	22873	broad.mit.edu	37	13	96238358	96238358	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr13:96238358C>T	uc001vmk.2	-	21	3103	c.2251G>A	c.(2251-2253)GAA>AAA	p.E751K	DZIP1_uc001vmi.2_5'UTR|DZIP1_uc001vmj.2_Missense_Mutation_p.E227K|DZIP1_uc001vml.2_Missense_Mutation_p.E732K|DZIP1_uc001vmm.2_5'Flank	NM_198968	NP_945319	Q86YF9	DZIP1_HUMAN	DAZ interacting protein 1 isoform 2	751					germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			AACATCTTTTCAACTTTTTCA	0.308		NaN											0	0	0	0.008291	0	10	26									
NALCN	259232	broad.mit.edu	37	13	101735186	101735186	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr13:101735186C>G	uc001vox.1	-	33	3928	c.3739G>C	c.(3739-3741)GTT>CTT	p.V1247L		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	1247	Helical; Name=S2 of repeat IV; (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					AAGGTGAAAACAACTGACATT	0.493		NaN											0	0	0	0.00632	0	26	106									
TPP2	7174	broad.mit.edu	37	13	103275268	103275268	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr13:103275268C>T	uc001vpi.3	+	6	765	c.662C>T	c.(661-663)TCT>TTT	p.S221F		NM_003291	NP_003282	P29144	TPP2_HUMAN	tripeptidyl peptidase II	221					proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TTGAGTAAATCTACCGTGTTG	0.343		NaN											0	0	0	0.003954	0	23	109									
CARS2	79587	broad.mit.edu	37	13	111340160	111340160	+	Missense_Mutation	SNP	G	G	A	rs143602497		TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr13:111340160G>A	uc001vrd.2	-	5	519	c.479C>T	c.(478-480)ACG>ATG	p.T160M	CARS2_uc010tjm.1_RNA	NM_024537	NP_078813	Q9HA77	SYCM_HUMAN	cysteinyl-tRNA synthetase 2, mitochondrial	160					cysteinyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|cysteine-tRNA ligase activity|metal ion binding				0	all_lung(23;3.61e-05)|Lung NSC(43;0.00144)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		BRCA - Breast invasive adenocarcinoma(86;0.163)		L-Cysteine(DB00151)	CAGGTACACCGTGGGTGGGAG	0.507		NaN											0	0	0	0.00361	0	47	131									
PROZ	8858	broad.mit.edu	37	13	113814360	113814360	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr13:113814360C>T	uc001vta.1	+	2	110	c.103C>T	c.(103-105)CTG>TTG	p.L35L	PROZ_uc010agr.1_Silent_p.L57L	NM_003891	NP_003882	P22891	PROZ_HUMAN	protein Z, vitamin K-dependent plasma	35					blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen	calcium ion binding|serine-type endopeptidase activity				0	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.216)	all cancers(43;0.104)		Menadione(DB00170)	AAACGACGTTCTGGTGAGGTG	0.517		NaN											0	0	0	0.00361	0	72	233									
FAM70B	348013	broad.mit.edu	37	13	114503880	114503880	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr13:114503880C>T	uc001vuh.2	+	6	531	c.504C>T	c.(502-504)TGC>TGT	p.C168C		NM_182614	NP_872420	Q8WV15	FA70B_HUMAN	family with sequence similarity 70, member B	168						integral to membrane					0	Lung NSC(43;0.00976)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_lung(25;0.123)|all_epithelial(44;0.133)	all cancers(43;0.181)			TCTATGCCTGCGGGAGGTGAG	0.647		NaN											0	0	0	0.004289	0	20	12									
PSME1	5720	broad.mit.edu	37	14	24606976	24606976	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr14:24606976G>A	uc001wmg.2	+	6	454	c.360G>A	c.(358-360)GAG>GAA	p.E120E	PSME1_uc001wmh.2_Silent_p.E120E	NM_006263	NP_006254	Q06323	PSME1_HUMAN	proteasome activator subunit 1 isoform 1	120					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|proteasome activator complex				ovary(1)	1				GBM - Glioblastoma multiforme(265;0.00831)		TGAAGCCTGAGATCAAGGATG	0.512		NaN											0	0	0	0.007835	0	29	48									
TGM1	7051	broad.mit.edu	37	14	24727513	24727513	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr14:24727513G>A	uc001wod.2	-	9	1504	c.1380C>T	c.(1378-1380)GCC>GCT	p.A460A	TGM1_uc010tog.1_Silent_p.A18A	NM_000359	NP_000350	P22735	TGM1_HUMAN	transglutaminase 1	460					cell envelope organization|keratinization|peptide cross-linking	cornified envelope|intrinsic to membrane	acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.0186)	L-Glutamine(DB00130)	CTTGGGGTGTGGCATCCACCA	0.592		NaN											0	0	0	0.003954	0	21	29									
NUBPL	80224	broad.mit.edu	37	14	32068580	32068580	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr14:32068580C>T	uc001wrk.3	+	4	432	c.377C>T	c.(376-378)TCA>TTA	p.S126L	NUBPL_uc010amj.2_RNA|NUBPL_uc010tpl.1_Missense_Mutation_p.S30L	NM_025152	NP_079428	Q8TB37	NUBPL_HUMAN	nucleotide binding protein-like	126					mitochondrial respiratory chain complex I assembly|mitochondrion morphogenesis	mitochondrion	4 iron, 4 sulfur cluster binding|ATP binding|metal ion binding				0	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.214)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0677)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0102)		CCGGAATTATCACAGAGTAAG	0.234		NaN											0	0	0	0.004007	0	17	26									
ARHGAP5	394	broad.mit.edu	37	14	32560834	32560834	+	Nonsense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr14:32560834C>G	uc001wrl.2	+	2	1198	c.959C>G	c.(958-960)TCA>TGA	p.S320*	ARHGAP5_uc001wrm.2_Nonsense_Mutation_p.S320*|ARHGAP5_uc001wrn.2_Nonsense_Mutation_p.S320*|ARHGAP5_uc001wro.2_Intron|ARHGAP5_uc001wrp.2_Intron	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	320	FF 1.				cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		AATACATTCTCAAAACATATA	0.299		NaN											0	0	0	0.007413	0	15	19									
CFL2	1073	broad.mit.edu	37	14	35182587	35182587	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr14:35182587C>G	uc001wsg.3	-	2	325	c.184G>C	c.(184-186)GAT>CAT	p.D62H	CFL2_uc010tpn.1_Missense_Mutation_p.D45H|CFL2_uc001wsh.3_Missense_Mutation_p.D62H|CFL2_uc001wsi.3_Intron|CFL2_uc001wsj.3_Intron	NM_021914	NP_068733	Q9Y281	COF2_HUMAN	cofilin 2	62	ADF-H.					cytoplasm|cytoskeleton|nuclear matrix	actin binding			breast(2)	2	Breast(36;0.0361)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;6.07e-06)|Lung(238;2.23e-05)|Epithelial(34;0.0387)|all cancers(34;0.0814)	GBM - Glioblastoma multiforme(112;0.0424)		TCTACAGTATCACCAATGTCA	0.398		NaN											0	0	0	0.003954	0	20	28									
C14orf106	55320	broad.mit.edu	37	14	45693269	45693269	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr14:45693269C>T	uc001wwf.2	-	11	2980	c.2521G>A	c.(2521-2523)GAA>AAA	p.E841K		NM_018353	NP_060823	Q6P0N0	M18BP_HUMAN	chromosome 14 open reading frame 106	841					cell division|CenH3-containing nucleosome assembly at centromere|mitosis	chromosome, centromeric region|nucleoplasm	DNA binding				0						TGAAGAGTTTCTTTGACGGAA	0.358		NaN											0	0	0	0.001168	0	5	12									
L2HGDH	79944	broad.mit.edu	37	14	50735964	50735964	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr14:50735964C>G	uc001wxu.2	-	7	902	c.823G>C	c.(823-825)GAT>CAT	p.D275H	L2HGDH_uc010tqn.1_Missense_Mutation_p.D275H|L2HGDH_uc010tqo.1_Missense_Mutation_p.D275H	NM_024884	NP_079160	Q9H9P8	L2HDH_HUMAN	L-2-hydroxyglutarate dehydrogenase precursor	275					2-oxoglutarate metabolic process|cellular protein metabolic process	integral to mitochondrial inner membrane	2-hydroxyglutarate dehydrogenase activity			ovary(2)	2	all_epithelial(31;0.000599)|Breast(41;0.0102)					ATTCGAGGATCAGGAGTGCAG	0.408		NaN											0	0	0	0.00361	0	52	72									
NID2	22795	broad.mit.edu	37	14	52477650	52477650	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr14:52477650G>A	uc001wzo.2	-	18	3900	c.3666C>T	c.(3664-3666)GTC>GTT	p.V1222V	NID2_uc010tqs.1_Silent_p.V1174V|NID2_uc010tqt.1_Silent_p.V1222V	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	1222	LDL-receptor class B 2.					basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					TGTAGAAGAGGACCTTGCGCT	0.532		NaN											0	0	0	0.002836	0	32	53									
C14orf135	64430	broad.mit.edu	37	14	60585115	60585115	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr14:60585115G>C	uc001xer.3	+	6	1467	c.945G>C	c.(943-945)TTG>TTC	p.L315F	C14orf135_uc001xeq.2_Missense_Mutation_p.L315F|C14orf135_uc010apm.2_RNA	NM_022495	NP_071940	Q63HM2	CN135_HUMAN	hepatitis C virus F protein-binding protein 2	549	Helical; (Potential).					integral to membrane				ovary(2)	2		Myeloproliferative disorder(585;0.163)		OV - Ovarian serous cystadenocarcinoma(108;0.127)		CTGTGCTTTTGACATCATGGA	0.338		NaN											0	0	0	0.000602	0	5	9									
SYNE2	23224	broad.mit.edu	37	14	64545285	64545285	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr14:64545285G>C	uc001xgm.2	+	55	11354	c.11124G>C	c.(11122-11124)CAG>CAC	p.Q3708H	SYNE2_uc001xgl.2_Missense_Mutation_p.Q3708H|SYNE2_uc010apy.2_Missense_Mutation_p.Q70H|SYNE2_uc010apw.1_Missense_Mutation_p.Q414H|SYNE2_uc010apx.1_Missense_Mutation_p.Q100H	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	3708	Potential.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TGTTGCAGCAGAAAAGCAAAA	0.358		NaN											0	0	0	0.00308	0	8	12									
SYNE2	23224	broad.mit.edu	37	14	64680977	64680977	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr14:64680977G>C	uc001xgm.2	+	106	19352	c.19122G>C	c.(19120-19122)CAG>CAC	p.Q6374H	SYNE2_uc001xgl.2_Missense_Mutation_p.Q6374H|SYNE2_uc010apy.2_Missense_Mutation_p.Q2759H|SYNE2_uc001xgn.2_Missense_Mutation_p.Q1336H|SYNE2_uc001xgo.2_RNA|SYNE2_uc010aqa.2_Missense_Mutation_p.Q344H|SYNE2_uc001xgq.2_Missense_Mutation_p.Q739H|SYNE2_uc001xgr.2_Missense_Mutation_p.Q157H|SYNE2_uc010tsi.1_Missense_Mutation_p.Q8H|SYNE2_uc001xgs.2_Missense_Mutation_p.Q8H|SYNE2_uc001xgt.2_5'Flank	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	6374	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		GAGAAATCCAGACTGATTCTT	0.512		NaN											0	0	0	0.00361	0	43	56									
C14orf4	64207	broad.mit.edu	37	14	77492329	77492329	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr14:77492329G>A	uc001xsy.2	-	1	2706	c.1807C>T	c.(1807-1809)CTG>TTG	p.L603L		NM_024496	NP_078772	Q9H1B7	I2BPL_HUMAN	chromosome 14 open reading frame 4	603	Pro-rich.					nucleus					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.00347)|KIRC - Kidney renal clear cell carcinoma(182;0.0878)		TGGGGTCCCAGAGGTgggggc	0.507		NaN											0	0	0	0.009096	0	3	4									
KIAA1737	85457	broad.mit.edu	37	14	77580381	77580381	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr14:77580381C>T	uc001xtd.2	+	4	1099	c.920C>T	c.(919-921)TCA>TTA	p.S307L	KIAA1737_uc001xtc.1_Missense_Mutation_p.S209L	NM_033426	NP_219494	Q9C0C6	K1737_HUMAN	KIAA1737 protein	307											0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0284)		GATATCTTTTCAGAGCAGCGG	0.478		NaN											0	0	0	0.010504	0	19	36									
ADCK1	57143	broad.mit.edu	37	14	78397944	78397944	+	Silent	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr14:78397944C>G	uc001xui.2	+	10	1389	c.1290C>G	c.(1288-1290)CTC>CTG	p.L430L	ADCK1_uc001xuj.2_Silent_p.L362L|ADCK1_uc001xul.2_Silent_p.L137L	NM_020421	NP_065154	Q86TW2	ADCK1_HUMAN	aarF domain containing kinase 1 isoform a	437	Protein kinase.					extracellular region	ATP binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)	3			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0376)		AGATGCTGCTCATCTTGAAGA	0.602		NaN											0	0	0	0.003954	0	25	43									
AKT1	207	broad.mit.edu	37	14	105242100	105242100	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr14:105242100G>A	uc001ypk.2	-	5	878	c.324C>T	c.(322-324)GAC>GAT	p.D108D	INF2_uc010tyi.1_Intron|AKT1_uc001ypl.2_Silent_p.D108D|AKT1_uc010axa.2_Silent_p.D108D|AKT1_uc001ypm.2_Silent_p.D108D|AKT1_uc001ypn.2_Silent_p.D108D|AKT1_uc010tyk.1_Silent_p.D46D	NM_005163	NP_005154	P31749	AKT1_HUMAN	AKT1 kinase	108	PH.				activation of pro-apoptotic gene products|activation-induced cell death of T cells|endocrine pancreas development|G-protein coupled receptor protein signaling pathway|glucose metabolic process|glycogen biosynthetic process|induction of apoptosis by intracellular signals|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|mRNA metabolic process|negative regulation of fatty acid beta-oxidation|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|nitric oxide biosynthetic process|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of blood vessel endothelial cell migration|positive regulation of cell growth|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of establishment of protein localization in plasma membrane|positive regulation of fat cell differentiation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|positive regulation of nitric oxide biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of peptidyl-serine phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|protein autophosphorylation|protein import into nucleus, translocation|regulation of neuron projection development|regulation of translation|response to fluid shear stress|response to heat|response to UV-A|T cell costimulation	cytosol|nucleoplasm|plasma membrane	enzyme binding|identical protein binding|nitric-oxide synthase regulator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|protein serine/threonine kinase activity			breast(86)|urinary_tract(12)|thyroid(10)|lung(7)|endometrium(5)|large_intestine(4)|skin(4)|prostate(3)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|NS(1)	134		all_cancers(154;3.77e-06)|all_lung(585;3.24e-07)|all_epithelial(191;3.45e-05)|all_neural(303;0.0459)|Melanoma(154;0.155)	all cancers(16;0.000486)|OV - Ovarian serous cystadenocarcinoma(23;0.00647)|Epithelial(46;0.0153)|GBM - Glioblastoma multiforme(11;0.116)	all cancers(159;0.0107)|OV - Ovarian serous cystadenocarcinoma(161;0.0132)|Epithelial(152;0.243)	Adenosine triphosphate(DB00171)|Arsenic trioxide(DB01169)	TCTTGAGGCCGTCAGCCACAG	0.617		1	Mis		breast|colorectal|ovarian|NSCLC								0	0	0	0.007291	0	21	7									
AHNAK2	113146	broad.mit.edu	37	14	105419487	105419487	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr14:105419487C>T	uc010axc.1	-	7	2421	c.2301G>A	c.(2299-2301)AAG>AAA	p.K767K	AHNAK2_uc001ypx.2_Silent_p.K667K	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	767						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CTTTGGGCATCTTCAAACTGG	0.617		NaN											0	0	0	0.00361	0	46	25									
UBE3A	7337	broad.mit.edu	37	15	25615955	25615955	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:25615955C>G	uc001zaq.2	-	4	1375	c.1375G>C	c.(1375-1377)GAA>CAA	p.E459Q	uc001zae.2_Intron|UBE3A_uc001zar.2_Missense_Mutation_p.E436Q|UBE3A_uc001zas.2_Missense_Mutation_p.E456Q|UBE3A_uc001zat.2_Missense_Mutation_p.E436Q	NM_000462	NP_000453	Q05086	UBE3A_HUMAN	ubiquitin protein ligase E3A isoform 2	459	Interaction with HCV core protein.				brain development|interspecies interaction between organisms|protein K48-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			upper_aerodigestive_tract(1)|ovary(1)|breast(1)	3		all_cancers(20;3.47e-21)|Breast(32;0.00123)		all cancers(64;2.78e-08)|Epithelial(43;8.85e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0155)|Lung(196;0.0616)		TTATCCATTTCTAGAACCTCA	0.353		NaN											0	0	0	0.000602	0	5	17									
KLF13	51621	broad.mit.edu	37	15	31619856	31619856	+	Silent	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:31619856C>G	uc001zfo.2	+	1	774	c.441C>G	c.(439-441)CTC>CTG	p.L147L		NM_015995	NP_057079	Q9Y2Y9	KLF13_HUMAN	Kruppel-like factor 13	147					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|zinc ion binding				0		all_lung(180;3.71e-11)		all cancers(64;1.11e-18)|Epithelial(43;1.73e-14)|GBM - Glioblastoma multiforme(186;0.00016)|Colorectal(1;0.00158)|BRCA - Breast invasive adenocarcinoma(123;0.00255)|COAD - Colon adenocarcinoma(236;0.0446)|READ - Rectum adenocarcinoma(1;0.13)|Lung(196;0.171)		AGCCCGGCCTCAGACAAAGGG	0.642		NaN											0	0	0	0.000602	0	4	6									
RYR3	6263	broad.mit.edu	37	15	34130198	34130198	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:34130198C>A	uc001zhi.2	+	89	12087	c.12017C>A	c.(12016-12018)CCA>CAA	p.P4006Q	RYR3_uc010bar.2_Missense_Mutation_p.P4001Q	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	4006					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GAACACATGCCAAACGATTCC	0.463		NaN											1	0	2.46799e-47	0.00361	2.70616e-47	78	114									
INO80	54617	broad.mit.edu	37	15	41339643	41339643	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:41339643C>G	uc001zni.2	-	23	2911	c.2698G>C	c.(2698-2700)GAA>CAA	p.E900Q	INO80_uc010ucu.1_RNA	NM_017553	NP_060023	Q9ULG1	INO80_HUMAN	INO80 complex homolog 1	900	Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL2.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			ovary(2)|pancreas(1)|skin(1)	4						TTTGCCATTTCTGCTGGAGAT	0.373		NaN											0	0	0	0.003755	0	26	21									
RPAP1	26015	broad.mit.edu	37	15	41816160	41816160	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:41816160C>T	uc001zod.2	-	17	2369	c.2245G>A	c.(2245-2247)GAG>AAG	p.E749K	RPAP1_uc001zoc.2_5'UTR	NM_015540	NP_056355	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	749						nucleus	DNA binding|DNA-directed RNA polymerase activity			large_intestine(1)	1		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		AGGCTGGCCTCAGCAGAATCA	0.587		NaN											0	0	0	0.00308	0	8	14									
JMJD7-PLA2G4B	8681	broad.mit.edu	37	15	42132996	42132996	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:42132996G>C	uc010bco.2	+	4	345	c.244G>C	c.(244-246)GAC>CAC	p.D82H	JMJD7-PLA2G4B_uc001zoo.3_Missense_Mutation_p.D313H|JMJD7-PLA2G4B_uc010bcn.2_Missense_Mutation_p.D313H|JMJD7-PLA2G4B_uc001zoq.3_5'UTR|JMJD7-PLA2G4B_uc001zor.1_5'Flank	NM_001114633	NP_001108105	P0C869	PA24B_HUMAN	phospholipase A2, group IVB	82	C2.				arachidonic acid metabolic process|calcium-mediated signaling|glycerophospholipid catabolic process|inflammatory response|parturition	cytosol|early endosome membrane|extracellular region|mitochondrial membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|calcium-dependent phospholipid binding|lysophospholipase activity			large_intestine(1)	1						GAAAGTCTTTGACCAGGACCT	0.597		NaN											0	0	0	0.005443	0	26	93									
USP8	9101	broad.mit.edu	37	15	50757369	50757369	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:50757369G>A	uc001zym.3	+	8	1167	c.667G>A	c.(667-669)GAA>AAA	p.E223K	USP8_uc001zyk.1_5'UTR|USP8_uc001zyl.3_Missense_Mutation_p.E223K|USP8_uc001zyn.3_Missense_Mutation_p.E223K|USP8_uc010ufh.1_Missense_Mutation_p.E146K|USP8_uc010bev.1_Intron	NM_001128611	NP_001122083	P40818	UBP8_HUMAN	ubiquitin specific peptidase 8	223	Rhodanese.				cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)|central_nervous_system(1)	2				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		CAGTGTTCCTGAAGAAGCCAT	0.378		NaN											0	0	0	0.00632	0	21	63									
LIPC	3990	broad.mit.edu	37	15	58838000	58838000	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:58838000G>C	uc010bga.1	+	7	1242	c.634G>C	c.(634-636)GAT>CAT	p.D212H	LIPC_uc010bfz.1_Missense_Mutation_p.D212H|LIPC_uc002afa.1_Missense_Mutation_p.D212H|LIPC_uc010bgb.1_Missense_Mutation_p.D110H|LIPC_uc010ugy.1_Missense_Mutation_p.D151H	NM_000236	NP_000227	P11150	LIPC_HUMAN	lipase C precursor	212					cholesterol homeostasis|chylomicron remnant clearance|fatty acid biosynthetic process|high-density lipoprotein particle remodeling|intermediate-density lipoprotein particle remodeling|low-density lipoprotein particle remodeling|phosphatidylcholine catabolic process|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle	apolipoprotein binding|heparin binding|low-density lipoprotein particle binding|phospholipase activity|triglyceride lipase activity			ovary(1)	1		Colorectal(260;0.215)		GBM - Glioblastoma multiforme(80;0.00213)|all cancers(107;0.00548)		TCTTTCTCCAGATGATGCCAA	0.537		NaN											0	0	0	0.00361	0	189	128									
VPS13C	54832	broad.mit.edu	37	15	62212771	62212771	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:62212771G>A	uc002agz.2	-	56	7212	c.7138C>T	c.(7138-7140)CAT>TAT	p.H2380Y	VPS13C_uc002aha.2_Missense_Mutation_p.H2337Y|VPS13C_uc002ahb.1_Missense_Mutation_p.H2380Y|VPS13C_uc002ahc.1_Missense_Mutation_p.H2337Y|VPS13C_uc002ahd.1_5'Flank	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	2380					protein localization					ovary(2)	2						GAAGAAATATGAATTGCCATT	0.313		NaN											0	0	0	0.012319	0	14	9									
VPS13C	54832	broad.mit.edu	37	15	62254674	62254674	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:62254674C>A	uc002agz.2	-	34	3573	c.3499G>T	c.(3499-3501)GAG>TAG	p.E1167*	VPS13C_uc002aha.2_Nonsense_Mutation_p.E1124*|VPS13C_uc002ahb.1_Nonsense_Mutation_p.E1167*|VPS13C_uc002ahc.1_Nonsense_Mutation_p.E1124*	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	1167					protein localization					ovary(2)	2						AAATCCCCCTCAGTAGCATCT	0.388		NaN											1	0	1.18608e-55	0.00361	1.30706e-55	121	92									
FBXL22	283807	broad.mit.edu	37	15	63893794	63893794	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:63893794G>A	uc002amn.2	+	2	649	c.635G>A	c.(634-636)AGA>AAA	p.R212K	uc002amj.2_5'Flank|uc002amk.2_5'Flank|uc002aml.2_5'Flank	NM_203373	NP_976307	Q6P050	FXL22_HUMAN	F-box and leucine-rich repeat protein 22	212											0						CGCACGGGCAGAAGGAGCCAC	0.716		NaN											0	0	0	0.006214	0	8	3									
SMAD3	4088	broad.mit.edu	37	15	67477081	67477081	+	Silent	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:67477081C>G	uc002aqj.2	+	7	1186	c.888C>G	c.(886-888)CTC>CTG	p.L296L	SMAD3_uc010ujr.1_Silent_p.L191L|SMAD3_uc010ujs.1_Silent_p.L252L|SMAD3_uc010ujt.1_Silent_p.L101L	NM_005902	NP_005893	P84022	SMAD3_HUMAN	mothers against decapentaplegic homolog 3	296	Sufficient for interaction with XPO4.|MH2.				activation of caspase activity|cell cycle arrest|cell-cell junction organization|evasion of host defenses by virus|immune response|induction of apoptosis|negative regulation of cell growth|negative regulation of mitotic cell cycle|negative regulation of protein catabolic process|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|protein stabilization|regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|transport|wound healing	cytosol|nuclear inner membrane|receptor complex	beta-catenin binding|co-SMAD binding|metal ion binding|protein homodimerization activity|protein kinase binding|R-SMAD binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor binding|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding			large_intestine(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5				Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(7;0.125)		GCGTGCGGCTCTACTACATCG	0.587		NaN											0	0	0	0.008361	0	24	87									
C15orf59	388135	broad.mit.edu	37	15	74032703	74032703	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:74032703G>A	uc002avy.2	-	2	782	c.437C>T	c.(436-438)ACG>ATG	p.T146M		NM_001039614	NP_001034703	Q2T9L4	CO059_HUMAN	hypothetical protein LOC388135	146										pancreas(1)	1						GGGGATGGGCGTGCCACCATT	0.667		NaN											0	0	0	0.004656	0	19	64									
CSK	1445	broad.mit.edu	37	15	75092810	75092810	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:75092810G>C	uc010bkb.1	+	7	703	c.520G>C	c.(520-522)GAG>CAG	p.E174Q	CSK_uc002ays.2_Missense_Mutation_p.E174Q|CSK_uc010bkc.1_5'UTR	NM_001127190	NP_001120662	P41240	CSK_HUMAN	c-src tyrosine kinase	174					blood coagulation|epidermal growth factor receptor signaling pathway|T cell costimulation|T cell receptor signaling pathway	centrosome|cytosol|Golgi apparatus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein C-terminus binding			lung(2)|central_nervous_system(1)	3						AAAGGTCATGGAGGGCACAGT	0.622		NaN									OREG0023291	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.007413	0	14	35									
GOLGA6D	653643	broad.mit.edu	37	15	75580671	75580671	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:75580671G>C	uc010uma.1	+	7	565	c.530G>C	c.(529-531)TGT>TCT	p.C177S	uc010umb.1_5'Flank	NM_001145224	NP_001138696	P0CG33	GOG6D_HUMAN	golgi autoantigen, golgin subfamily a, 6D	177	Potential.										0						CGGGCTCTCTGTGCTGTGTCT	0.557		NaN											0	0	0	0.010729	0	6	110									
IMP3	55272	broad.mit.edu	37	15	75932413	75932413	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:75932413C>T	uc002bat.2	-	2	1041	c.97G>A	c.(97-99)GTG>ATG	p.V33M	IMP3_uc010bkl.1_Missense_Mutation_p.V33M	NM_018285	NP_060755	Q9NV31	IMP3_HUMAN	IMP3, U3 small nucleolar ribonucleoprotein	33	Arg-rich.				rRNA processing	nucleolus|ribonucleoprotein complex	protein binding|rRNA binding				0						CGCCGCAGCACGCGCAGCTCG	0.657		NaN											0	0	0	0.010729	0	8	21									
MESDC2	23184	broad.mit.edu	37	15	81282044	81282044	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:81282044C>A	uc002bfy.1	-	1	162	c.89G>T	c.(88-90)GGG>GTG	p.G30V	MESDC2_uc002bfx.2_RNA|MESDC2_uc010uno.1_RNA	NM_015154	NP_055969	Q14696	MESD_HUMAN	mesoderm development candidate 2	30	Chaperone domain (By similarity).				mesoderm development|protein folding|Wnt receptor signaling pathway	endoplasmic reticulum					0						CGCGCAGGACCCAGGCGGTGG	0.567		NaN											1	0	3.5997e-14	0.002299	3.80161e-14	21	44									
SEMA4B	10509	broad.mit.edu	37	15	90764303	90764303	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:90764303C>G	uc002boy.2	+	6	856	c.573C>G	c.(571-573)TTC>TTG	p.F191L	SEMA4B_uc002boz.2_Missense_Mutation_p.F191L|SEMA4B_uc010uqd.1_Missense_Mutation_p.F29L|SEMA4B_uc002bpa.2_Missense_Mutation_p.F29L|SEMA4B_uc010bnv.1_5'Flank	NM_020210	NP_064595			semaphorin 4B precursor											ovary(1)|breast(1)|kidney(1)	3	Melanoma(11;0.00551)|Lung NSC(78;0.0125)|all_lung(78;0.0272)		BRCA - Breast invasive adenocarcinoma(143;0.0107)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.217)			ACCCGAATTTCAAGTCCACTG	0.572		NaN									OREG0023469	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00245	0	11	5									
FURIN	5045	broad.mit.edu	37	15	91423349	91423349	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:91423349C>T	uc002bpu.1	+	13	1618	c.1402C>T	c.(1402-1404)CGG>TGG	p.R468W		NM_002569	NP_002560	P09958	FURIN_HUMAN	furin preproprotein	468					cell proliferation|negative regulation of low-density lipoprotein particle receptor catabolic process|negative regulation of transforming growth factor-beta1 production|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|Notch signaling pathway|peptide biosynthetic process|peptidyl-glutamic acid carboxylation|post-translational protein modification|secretion by cell|signal peptide processing|transforming growth factor beta receptor signaling pathway|viral assembly, maturation, egress, and release	cell surface|Golgi lumen|Golgi membrane|integral to membrane|membrane raft|plasma membrane|trans-Golgi network|trans-Golgi network transport vesicle	metal ion binding|nerve growth factor binding|peptide binding|protease binding|serine-type endopeptidase activity|serine-type endopeptidase inhibitor activity			central_nervous_system(4)|lung(2)|breast(1)	7	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			GCTCGAGGTGCGGAAGACCGT	0.667		NaN											0	0	0	0.001855	0	10	40									
OR4F15	390649	broad.mit.edu	37	15	102358647	102358647	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:102358647C>G	uc010uts.1	+	1	258	c.258C>G	c.(256-258)TTC>TTG	p.F86L		NM_001001674	NP_001001674	Q8NGB8	O4F15_HUMAN	olfactory receptor, family 4, subfamily F,	86	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			GTGATATTTTCAAGAAGCACA	0.463		NaN											0	0	0	0.010504	0	22	84									
RAB40C	57799	broad.mit.edu	37	16	677451	677451	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:677451C>T	uc002chr.2	+	6	791	c.675C>T	c.(673-675)TTC>TTT	p.F225F	RAB40C_uc002chq.2_Silent_p.F206F|WFIKKN1_uc002chs.1_5'Flank	NM_021168	NP_066991	Q96S21	RB40C_HUMAN	RAB40C, member RAS oncogene family	225	SOCS box.				protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding				0		Hepatocellular(780;0.0218)				TCAAGTCCTTCTCGATGGCCA	0.652		NaN											0	0	0	0.00361	0	54	172									
CASKIN1	57524	broad.mit.edu	37	16	2237255	2237255	+	Silent	SNP	C	C	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:2237255C>A	uc010bsg.1	-	8	779	c.747G>T	c.(745-747)GTG>GTT	p.V249V		NM_020764	NP_065815	Q8WXD9	CSKI1_HUMAN	CASK interacting protein 1	249	ANK 6.				signal transduction	cytoplasm				skin(2)	2						AGGTGTTCCTCACGTGGGCAT	0.632		NaN											1	0	6.00712e-18	0.012213	6.46845e-18	27	73									
THOC6	79228	broad.mit.edu	37	16	3076366	3076366	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:3076366G>C	uc002ctb.2	+	6	659	c.363G>C	c.(361-363)AGG>AGC	p.R121S	HCFC1R1_uc002csx.1_5'Flank|HCFC1R1_uc002csy.1_5'Flank|HCFC1R1_uc002csz.1_5'Flank|THOC6_uc002ctd.2_Missense_Mutation_p.R121S|THOC6_uc002ctc.2_Missense_Mutation_p.R97S|THOC6_uc002cta.2_Missense_Mutation_p.R97S	NM_024339	NP_077315	Q86W42	THOC6_HUMAN	WD repeat domain 58 isoform 1	121				R -> S (in Ref. 1; BAG36782).	intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	RNA binding			ovary(1)|central_nervous_system(1)	2						CCTTCCCCAGGACCAGCCTGG	0.572		NaN											0	0	0	0.007413	0	15	40									
DNAH3	55567	broad.mit.edu	37	16	21128567	21128567	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:21128567G>C	uc010vbe.1	-	12	1771	c.1771C>G	c.(1771-1773)CAA>GAA	p.Q591E	DNAH3_uc002die.2_Missense_Mutation_p.Q531E	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	591	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		TTGAAAGTTTGAATCAAAAAA	0.363		NaN											0	0	0	0.000602	0	4	58									
ERN2	10595	broad.mit.edu	37	16	23724503	23724503	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:23724503C>T	uc002dma.3	-	1	319	c.150G>A	c.(148-150)GCG>GCA	p.A50A	ERN2_uc010bxp.2_Silent_p.A50A|ERN2_uc010bxq.1_5'UTR	NM_033266	NP_150296	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signalling 2	2					apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		TGACCGCACTCGCCATAGCGC	0.736		NaN											0	0	0	0.004482	0	7	5									
XPO6	23214	broad.mit.edu	37	16	28145186	28145186	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:28145186C>T	uc002dpa.1	-	11	2013	c.1512G>A	c.(1510-1512)CTG>CTA	p.L504L	XPO6_uc002dpb.1_Silent_p.L490L|XPO6_uc010vcp.1_Silent_p.L504L	NM_015171	NP_055986	Q96QU8	XPO6_HUMAN	exportin 6	504					protein export from nucleus		protein binding|protein transporter activity			ovary(1)|skin(1)	2						CGTGCGTGGGCAGGAGCTCCA	0.587		NaN											0	0	0	0.00361	0	72	48									
RNF40	9810	broad.mit.edu	37	16	30775620	30775620	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:30775620C>G	uc002dzq.2	+	5	686	c.563C>G	c.(562-564)TCC>TGC	p.S188C	C16orf93_uc002dzm.2_5'Flank|C16orf93_uc002dzn.2_5'Flank|C16orf93_uc002dzo.2_5'Flank|C16orf93_uc002dzp.2_5'Flank|RNF40_uc010caa.2_Missense_Mutation_p.S188C|RNF40_uc010cab.2_Missense_Mutation_p.S188C|RNF40_uc010vfa.1_Intron|RNF40_uc002dzr.2_Missense_Mutation_p.S188C|RNF40_uc010vfb.1_Intron	NM_014771	NP_055586	O75150	BRE1B_HUMAN	ring finger protein 40	188					histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)	1			Colorectal(24;0.198)			ATGGAGTTCTCCAAGGCAGCT	0.627		NaN											0	0	0	0.007413	0	14	57									
RNF40	9810	broad.mit.edu	37	16	30776275	30776275	+	Silent	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:30776275C>G	uc002dzq.2	+	6	789	c.666C>G	c.(664-666)CTC>CTG	p.L222L	C16orf93_uc002dzm.2_5'Flank|C16orf93_uc002dzn.2_5'Flank|C16orf93_uc002dzo.2_5'Flank|C16orf93_uc002dzp.2_5'Flank|RNF40_uc010caa.2_Silent_p.L222L|RNF40_uc010cab.2_Silent_p.L222L|RNF40_uc010vfa.1_Intron|RNF40_uc002dzr.2_Silent_p.L222L|RNF40_uc010vfb.1_Intron	NM_014771	NP_055586	O75150	BRE1B_HUMAN	ring finger protein 40	222	Potential.				histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)	1			Colorectal(24;0.198)			GTGAGCCCCTCAGTGAGGCGG	0.602		NaN											0	0	0	0.010504	0	16	81									
LONP2	83752	broad.mit.edu	37	16	48286132	48286132	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:48286132C>G	uc002efi.1	+	2	413	c.324C>G	c.(322-324)TTC>TTG	p.F108L	LONP2_uc010vgm.1_RNA|LONP2_uc002efj.1_Missense_Mutation_p.F108L	NM_031490	NP_113678	Q86WA8	LONP2_HUMAN	peroxisomal LON protease-like	108	Lon.				misfolded or incompletely synthesized protein catabolic process|protein targeting to peroxisome|signal peptide processing	nucleoid|peroxisomal matrix	ATP binding|ATP-dependent peptidase activity|enzyme binding|sequence-specific DNA binding|serine-type endopeptidase activity				0						TATGCCGTTTCCAGATTGTAC	0.502		NaN											0	0	0	0.008871	0	17	16									
IRX6	79190	broad.mit.edu	37	16	55363210	55363210	+	Silent	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:55363210G>C	uc002ehy.2	+	5	1853	c.1320G>C	c.(1318-1320)CCG>CCC	p.P440P	IRX6_uc002ehx.2_Silent_p.P440P	NM_024335	NP_077311	P78412	IRX6_HUMAN	iroquois homeobox protein 6	440						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(1)	6						GCCAGTACCCGTCTGGAGCAG	0.627		NaN											0	0	0	0.009096	0	3	51									
CCDC135	84229	broad.mit.edu	37	16	57731954	57731954	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:57731954G>A	uc002emi.2	+	2	182	c.93G>A	c.(91-93)ATG>ATA	p.M31I	CCDC135_uc002emj.2_Missense_Mutation_p.M31I|CCDC135_uc002emk.2_Missense_Mutation_p.M31I	NM_032269	NP_115645	Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	31	Potential.					cytoplasm				central_nervous_system(1)	1						TGGAGAAAATGATGAGGCCAG	0.438		NaN											0	0	0	0.008291	0	10	13									
CDH5	1003	broad.mit.edu	37	16	66423281	66423281	+	Missense_Mutation	SNP	A	A	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:66423281A>C	uc002eom.3	+	5	793	c.637A>C	c.(637-639)AAA>CAA	p.K213Q	CDH5_uc002eon.1_Missense_Mutation_p.K213Q	NM_001795	NP_001786	P33151	CADH5_HUMAN	cadherin 5, type 2 preproprotein	213	Cadherin 2.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		CACAATAACGAAAAGCTTGGA	0.443		NaN											0	0	0	0.006122	0	14	32									
CDH5	1003	broad.mit.edu	37	16	66431938	66431938	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:66431938G>A	uc002eom.3	+	9	1570	c.1414G>A	c.(1414-1416)GAG>AAG	p.E472K		NM_001795	NP_001786	P33151	CADH5_HUMAN	cadherin 5, type 2 preproprotein	472	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		AGTTTTGGATGAGAATGACAA	0.542		NaN											0	0	0	0.00361	0	72	96									
SLC7A6	9057	broad.mit.edu	37	16	68325477	68325477	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:68325477C>T	uc002evt.1	+	8	1244	c.935C>T	c.(934-936)ACG>ATG	p.T312M	SLC7A6_uc010cfb.1_RNA|SLC7A6_uc002evu.1_Missense_Mutation_p.T312M|SLC7A6_uc002evv.1_RNA|SLC7A6_uc010cfc.1_RNA	NM_001076785	NP_001070253	Q92536	YLAT2_HUMAN	solute carrier family 7 (cationic amino acid	312	Helical; (Potential).				blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	basolateral plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|antiporter activity			central_nervous_system(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.034)|Epithelial(162;0.0948)		GCTGACCAGACGTTTGGCATG	0.502		NaN											0	0	0	0.00361	0	67	79									
PRMT7	54496	broad.mit.edu	37	16	68389659	68389659	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:68389659G>C	uc002evy.1	+	17	1960	c.1684G>C	c.(1684-1686)GAG>CAG	p.E562Q	PRMT7_uc010vlg.1_Missense_Mutation_p.E512Q|PRMT7_uc002evz.1_Missense_Mutation_p.E334Q|PRMT7_uc010cfd.1_Missense_Mutation_p.E54Q	NM_019023	NP_061896	Q9NVM4	ANM7_HUMAN	protein arginine methyltransferase 7	562					cell differentiation|DNA methylation involved in gamete generation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	[myelin basic protein]-arginine N-methyltransferase activity|histone methyltransferase activity (H4-R3 specific)|protein-arginine omega-N monomethyltransferase activity|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0155)|Epithelial(162;0.0629)		CAGGGAAGCTGAGCCCCACCC	0.677		NaN											0	0	0	0.006214	0	10	8									
COG8	84342	broad.mit.edu	37	16	69368866	69368866	+	Nonsense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:69368866G>C	uc002ewy.2	-	3	1042	c.971C>G	c.(970-972)TCA>TGA	p.S324*	COG8_uc002ewz.3_Nonsense_Mutation_p.S324*	NM_032382	NP_115758	Q96MW5	COG8_HUMAN	component of oligomeric golgi complex 8	324					protein transport	Golgi membrane|Golgi transport complex				ovary(1)	1						CAGGAATTGTGAGACCTTCTG	0.592		NaN											0	0	0	0.005443	0	25	59									
COG8	84342	broad.mit.edu	37	16	69370435	69370435	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:69370435C>T	uc002ewy.2	-	2	629	c.558G>A	c.(556-558)AGG>AGA	p.R186R	COG8_uc002ewz.3_Silent_p.R186R	NM_032382	NP_115758	Q96MW5	COG8_HUMAN	component of oligomeric golgi complex 8	186					protein transport	Golgi membrane|Golgi transport complex				ovary(1)	1						AAGAGTATTTCCTCTCCAGTC	0.488		NaN											0	0	0	0.001368	0	9	36									
COG8	84342	broad.mit.edu	37	16	69373450	69373450	+	Silent	SNP	C	C	T	rs142062440		TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:69373450C>T	uc002ewy.2	-	1	77	c.6G>A	c.(4-6)GCG>GCA	p.A2A	COG8_uc002ewz.3_Silent_p.A2A|NIP7_uc002exa.2_5'Flank|NIP7_uc002exb.2_5'Flank	NM_032382	NP_115758	Q96MW5	COG8_HUMAN	component of oligomeric golgi complex 8	2					protein transport	Golgi membrane|Golgi transport complex				ovary(1)	1						TCGCCGCGGTCGCCATCTTCC	0.622		NaN									OREG0023907	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008871	0	17	25									
BANP	54971	broad.mit.edu	37	16	88017774	88017774	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:88017774C>G	uc002fkr.2	+	4	468	c.244C>G	c.(244-246)CTG>GTG	p.L82V	BANP_uc002fkp.2_Missense_Mutation_p.L91V|BANP_uc002fkq.2_Missense_Mutation_p.L91V|BANP_uc010vow.1_Missense_Mutation_p.L90V|BANP_uc002fks.3_Missense_Mutation_p.L90V|BANP_uc002fko.1_Translation_Start_Site|BANP_uc010vov.1_Missense_Mutation_p.L96V	NM_079837	NP_524576	Q8N9N5	BANP_HUMAN	BTG3 associated nuclear protein isoform b	83	Potential.				cell cycle|chromatin modification|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0				BRCA - Breast invasive adenocarcinoma(80;0.00551)		AAAGCTGGATCTGGTCACGAA	0.527		NaN											0	0	0	0.000602	0	4	5									
ANKRD11	29123	broad.mit.edu	37	16	89352493	89352493	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:89352493G>A	uc002fmx.1	-	8	1307	c.846C>T	c.(844-846)CTC>CTT	p.L282L	ANKRD11_uc002fmy.1_Silent_p.L282L|ANKRD11_uc002fnc.1_Silent_p.L282L|ANKRD11_uc002fnb.1_Silent_p.L239L	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	282	ANK 4.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		TGCCTAACAGGAGGTTCACCA	0.587		NaN											0	0	0	0.00361	0	68	74									
SMYD4	114826	broad.mit.edu	37	17	1690794	1690794	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:1690794C>G	uc002ftm.3	-	6	1810	c.1642G>C	c.(1642-1644)GTG>CTG	p.V548L	SMYD4_uc002ftn.1_Missense_Mutation_p.V403L	NM_052928	NP_443160	Q8IYR2	SMYD4_HUMAN	SET and MYND domain containing 4	548	SET.						zinc ion binding			skin(3)|kidney(2)	5						ATGAAGGACACGCTGGTGTTG	0.577		NaN											0	0	0	0.004672	0	3	18									
CAMTA2	23125	broad.mit.edu	37	17	4876991	4876991	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:4876991C>T	uc002gah.1	-	13	2198	c.2090G>A	c.(2089-2091)TGG>TAG	p.W697*	CAMTA2_uc010cku.1_Nonsense_Mutation_p.W720*|CAMTA2_uc002gag.1_Nonsense_Mutation_p.W696*|CAMTA2_uc002gai.1_Nonsense_Mutation_p.W699*|CAMTA2_uc010ckv.1_Nonsense_Mutation_p.W344*	NM_015099	NP_055914	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	697					cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			ovary(1)	1						AGGACCCTTCCAGGTGGAGCG	0.612		NaN											0	0	0	0.012319	0	17	103									
GPR172B	55065	broad.mit.edu	37	17	4937171	4937171	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:4937171C>G	uc002gap.3	-	3	1326	c.613G>C	c.(613-615)GTC>CTC	p.V205L	GPR172B_uc002gao.3_Missense_Mutation_p.V205L|GPR172B_uc010ckw.2_Missense_Mutation_p.V83L|GPR172B_uc010ckx.2_Missense_Mutation_p.V205L	NM_001104577	NP_001098047	Q9NWF4	RFT_HUMAN	G protein-coupled receptor 172B precursor	205	Helical; (Potential).					integral to plasma membrane	receptor activity|riboflavin transporter activity				0						GCTGAAGTGACCAGAAGGGCA	0.622		NaN											0	0	0	0.004878	0	30	189									
C17orf74	201243	broad.mit.edu	37	17	7330189	7330189	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:7330189C>T	uc002ggw.2	+	3	952	c.879C>T	c.(877-879)GTC>GTT	p.V293V	FGF11_uc010vtw.1_Intron	NM_175734	NP_783861	Q0P670	CQ074_HUMAN	hypothetical protein LOC201243	293						integral to membrane					0		Prostate(122;0.157)				CCTCTTGGGTCCCCGTGGGGC	0.677		NaN											0	0	0	0.008871	0	18	102									
TP53	7157	broad.mit.edu	37	17	7578275	7578275	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:7578275G>A	uc002gim.2	-	6	768	c.574C>T	c.(574-576)CAG>TAG	p.Q192*	TP53_uc002gig.1_Nonsense_Mutation_p.Q192*|TP53_uc002gih.2_Nonsense_Mutation_p.Q192*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.Q60*|TP53_uc010cng.1_Nonsense_Mutation_p.Q60*|TP53_uc002gii.1_Nonsense_Mutation_p.Q60*|TP53_uc010cnh.1_Nonsense_Mutation_p.Q192*|TP53_uc010cni.1_Nonsense_Mutation_p.Q192*|TP53_uc002gij.2_Nonsense_Mutation_p.Q192*|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Nonsense_Mutation_p.Q99*|TP53_uc002gio.2_Nonsense_Mutation_p.Q60*|TP53_uc010vug.1_Nonsense_Mutation_p.Q153*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	192	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Q -> P (in sporadic cancers; somatic mutation).|Q -> H (in sporadic cancers; somatic mutation).|Q -> R (in sporadic cancers; somatic mutation).|QH -> HN (in a sporadic cancer; somatic mutation).|QH -> HY (in a sporadic cancer; somatic mutation).|Q -> L (in sporadic cancers; somatic mutation).|Q -> K (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q192*(64)|p.0?(7)|p.Q192R(5)|p.A189_V197delAPPQHLIRV(4)|p.Q192H(3)|p.P191fs*53(2)|p.G187fs*16(2)|p.Q192Q(2)|p.P191del(2)|p.K164_P219del(1)|p.P191fs*6(1)|p.A189_Q192>E(1)|p.P191fs*15(1)|p.P191_Q192delPQ(1)|p.Q192>XXXXXXXXX(1)|p.Q192K(1)|p.A189fs*53(1)|p.Q192fs*56(1)|p.Q192del(1)|p.Q192fs*16(1)|p.L188_P191del(1)|p.Q192fs*30(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATAAGATGCTGAGGAGGGGCC	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.00361	0	87	8									
DNAH2	146754	broad.mit.edu	37	17	7696168	7696168	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:7696168G>A	uc002giu.1	+	46	7353	c.7339G>A	c.(7339-7341)GCA>ACA	p.A2447T		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	2447	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CAACATGTCCGCACAGGTGTG	0.647		NaN											0	0	0	0.000602	0	4	167									
PER1	5187	broad.mit.edu	37	17	8045717	8045717	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:8045717C>T	uc002gkd.2	-	21	3557	c.3319G>A	c.(3319-3321)GAG>AAG	p.E1107K	PER1_uc010cns.2_5'Flank|PER1_uc010vuq.1_RNA	NM_002616	NP_002607	O15534	PER1_HUMAN	period 1	1107					circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			lung(2)|breast(2)|skin(2)|large_intestine(1)|ovary(1)|kidney(1)	9						gccccagcctcagcctcggAA	0.443		NaN	T	ETV6	AML|CMML			Other_conserved_DNA_damage_response_genes					0	0	0	0.012213	0	30	1									
PER1	5187	broad.mit.edu	37	17	8048196	8048196	+	Silent	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:8048196C>G	uc002gkd.2	-	18	2572	c.2334G>C	c.(2332-2334)CTG>CTC	p.L778L	PER1_uc010cns.2_5'Flank|PER1_uc010vuq.1_RNA|PER1_uc010vur.1_Silent_p.L762L	NM_002616	NP_002607	O15534	PER1_HUMAN	period 1	778	CSNK1E binding domain (By similarity).				circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			lung(2)|breast(2)|skin(2)|large_intestine(1)|ovary(1)|kidney(1)	9						CGGCCTTGGTCAGCCCCACTG	0.433		NaN	T	ETV6	AML|CMML			Other_conserved_DNA_damage_response_genes					0	0	0	0.008871	0	19	2									
RCVRN	5957	broad.mit.edu	37	17	9808346	9808346	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:9808346C>T	uc002gme.1	-	1	339	c.152G>A	c.(151-153)AGC>AAC	p.S51N		NM_002903	NP_002894	P35243	RECO_HUMAN	recoverin	51	EF-hand 1.				visual perception		calcium ion binding|calcium sensitive guanylate cyclase activator activity				0						GGCGTAGATGCTCTGGAACTG	0.602		NaN											0	0	0	0.001984	0	6	12									
SUPT6H	6830	broad.mit.edu	37	17	27011877	27011877	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:27011877C>G	uc002hby.2	+	19	2475	c.2385C>G	c.(2383-2385)TTC>TTG	p.F795L	SUPT6H_uc010crt.2_Missense_Mutation_p.F795L	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	795					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					ACCCTGTGTTCTGCGCCCTGG	0.443		NaN											0	0	0	0.00361	0	93	42									
ZNF207	7756	broad.mit.edu	37	17	30678846	30678846	+	Missense_Mutation	SNP	A	A	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:30678846A>G	uc002hhh.3	+	2	231	c.83A>G	c.(82-84)CAG>CGG	p.Q28R	ZNF207_uc002hhj.3_Missense_Mutation_p.Q28R|ZNF207_uc002hhi.3_Missense_Mutation_p.Q28R|ZNF207_uc010csz.2_Missense_Mutation_p.Q31R|ZNF207_uc002hhk.1_Missense_Mutation_p.Q28R	NM_003457	NP_003448	O43670	ZN207_HUMAN	zinc finger protein 207 isoform a	28	C2H2-type 1.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Breast(31;0.116)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.239)			ATCCTTATTCAGCACCAAAAA	0.343		NaN											0	0	0	0.007835	0	38	47									
GGNBP2	79893	broad.mit.edu	37	17	34937963	34937963	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:34937963G>A	uc002hnb.2	+	9	1459	c.1210G>A	c.(1210-1212)GAG>AAG	p.E404K	GGNBP2_uc002hna.2_Missense_Mutation_p.E404K|GGNBP2_uc002hnc.1_Missense_Mutation_p.E233K	NM_024835	NP_079111	Q9H3C7	GGNB2_HUMAN	zinc finger protein 403	404					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasmic membrane-bounded vesicle				ovary(2)	2		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		AGTAAGCCAAGAGAAGGTAAT	0.279		NaN											0	0	0	0.004656	0	22	35									
MLLT6	4302	broad.mit.edu	37	17	36875796	36875796	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:36875796C>T	uc002hqi.3	+	13	1982	c.1969C>T	c.(1969-1971)CGG>TGG	p.R657W	MLLT6_uc002hqj.2_Missense_Mutation_p.R92W|MLLT6_uc002hqk.3_5'UTR	NM_005937	NP_005928	P55198	AF17_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	657					regulation of transcription, DNA-dependent	nucleus	protein binding|zinc ion binding			breast(3)|prostate(1)|lung(1)|skin(1)	6	Breast(7;4.43e-21)					CTGCAGCTTCCGGTGTCGGGG	0.657		NaN	T	MLL	AL								0	0	0	0.010504	0	16	35									
TCAP	8557	broad.mit.edu	37	17	37822334	37822334	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:37822334C>T	uc002hsh.2	+	2	490	c.476C>T	c.(475-477)TCC>TTC	p.S159F	PNMT_uc002hsi.1_5'Flank	NM_003673	NP_003664	O15273	TELT_HUMAN	telethonin	159					adult heart development|cardiac muscle contraction|cardiac muscle fiber development|cardiac muscle tissue morphogenesis|detection of mechanical stimulus|muscle filament sliding|response to stress|sarcomere organization|skeletal muscle contraction|skeletal muscle myosin thick filament assembly|skeletal muscle thin filament assembly	cytosol|Z disc	structural constituent of muscle|titin binding|titin Z domain binding				0	all_cancers(6;6.59e-85)|all_epithelial(6;2.89e-103)|Breast(7;1.05e-86)|Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;3.87e-45)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			CTGTCCCGCTCCATGTCCCAG	0.657		NaN											0	0	0	0.00361	0	129	166									
GSDMA	284110	broad.mit.edu	37	17	38130640	38130640	+	Missense_Mutation	SNP	T	T	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:38130640T>G	uc002htl.1	+	9	984	c.866T>G	c.(865-867)CTT>CGT	p.L289R	GSDMA_uc002htm.1_Missense_Mutation_p.L289R	NM_178171	NP_835465	Q96QA5	GSDMA_HUMAN	gasdermin 1	289					apoptosis|induction of apoptosis	perinuclear region of cytoplasm					0						CTCAGCAAACTTCTAGGGAAG	0.512		NaN											0	0	0	0.004672	0	3	20									
KLHL10	317719	broad.mit.edu	37	17	40004197	40004197	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:40004197G>C	uc010cxr.2	+	5	1607	c.1465G>C	c.(1465-1467)GAT>CAT	p.D489H	KLHL10_uc010wfw.1_Missense_Mutation_p.D401H	NM_152467	NP_689680	Q6JEL2	KLH10_HUMAN	kelch-like 10	489	Kelch 5.					cytoplasm				ovary(1)|lung(1)|breast(1)|central_nervous_system(1)	4		Breast(137;0.000162)				AGGTGGCTTTGATGGAGCTAA	0.483		NaN											0	0	0	0.00361	0	86	113									
EFCAB3	146779	broad.mit.edu	37	17	60493508	60493508	+	Missense_Mutation	SNP	A	A	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:60493508A>G	uc002izu.1	+	10	1213	c.1135A>G	c.(1135-1137)ACA>GCA	p.T379A	EFCAB3_uc010wpc.1_Missense_Mutation_p.T431A	NM_173503	NP_775774	Q8N7B9	EFCB3_HUMAN	EF-hand calcium binding domain 3 isoform b	379							calcium ion binding			skin(1)	1			BRCA - Breast invasive adenocarcinoma(2;2.27e-11)			TTCTACTTATACATGGTCCTG	0.408		NaN											0	0	0	0.00361	0	46	54									
TACO1	51204	broad.mit.edu	37	17	61678640	61678640	+	Silent	SNP	C	C	T	rs141350830		TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:61678640C>T	uc002jbd.2	+	1	398	c.198C>T	c.(196-198)GTC>GTT	p.V66V		NM_016360	NP_057444	Q9BSH4	TACO1_HUMAN	translational activator of mitochondrially	66					regulation of translation	mitochondrion					0						GGTCCAAAGTCAGGCACATCA	0.637		NaN											0	0	0	0.00632	0	25	36									
SMURF2	64750	broad.mit.edu	37	17	62543775	62543775	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:62543775G>C	uc002jep.1	-	17	2402	c.2014C>G	c.(2014-2016)CTT>GTT	p.L672V	SMURF2_uc002jeq.1_Missense_Mutation_p.L431V|SMURF2_uc002jer.1_Missense_Mutation_p.L431V	NM_022739	NP_073576	Q9HAU4	SMUF2_HUMAN	SMAD specific E3 ubiquitin protein ligase 2	672	HECT.				BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|membrane raft|nucleus|plasma membrane|ubiquitin ligase complex	identical protein binding|SMAD binding|ubiquitin-protein ligase activity			skin(3)|lung(1)	4	Breast(5;1.32e-14)		BRCA - Breast invasive adenocarcinoma(8;9.88e-12)			ACAAACTGAAGCAATCTTGCT	0.517		NaN											0	0	0	0.00361	0	101	106									
FAM20A	54757	broad.mit.edu	37	17	66535515	66535515	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:66535515C>T	uc002jho.2	-	10	1612	c.1324G>A	c.(1324-1326)GAA>AAA	p.E442K	FAM20A_uc010wqp.1_Missense_Mutation_p.E304K|PRKAR1A_uc002jhm.2_Intron|FAM20A_uc002jhn.2_Missense_Mutation_p.E153K	NM_017565	NP_060035	Q96MK3	FA20A_HUMAN	family with sequence similarity 20, member A	442						extracellular region					0	Breast(10;1.64e-13)					ATGGAGATTTCATCATGGGAG	0.527		NaN											0	0	0	0.00361	0	36	159									
SDK2	54549	broad.mit.edu	37	17	71391400	71391400	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:71391400G>A	uc010dfm.2	-	25	3486	c.3486C>T	c.(3484-3486)ATC>ATT	p.I1162I	SDK2_uc002jjt.3_Silent_p.I321I|SDK2_uc010dfn.2_Silent_p.I841I	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	1162	Extracellular (Potential).|Fibronectin type-III 6.				cell adhesion	integral to membrane				ovary(2)	2						CCAGGTCCTCGATGGTGTAGT	0.652		NaN											0	0	0	0.010729	0	11	59									
FDXR	2232	broad.mit.edu	37	17	72860373	72860373	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:72860373G>A	uc002jly.2	-	9	986	c.899C>T	c.(898-900)TCC>TTC	p.S300F	FDXR_uc010wri.1_Missense_Mutation_p.S248F|FDXR_uc010wrj.1_Missense_Mutation_p.S298F|FDXR_uc002jlw.2_Missense_Mutation_p.S57F|FDXR_uc002jlx.2_Missense_Mutation_p.S306F|FDXR_uc002jmc.2_Missense_Mutation_p.S272F|FDXR_uc010wrk.1_Missense_Mutation_p.S331F|FDXR_uc010wrl.1_Missense_Mutation_p.S343F|FDXR_uc002jma.2_Missense_Mutation_p.S301F|FDXR_uc010wrm.1_Missense_Mutation_p.S260F|FDXR_uc002jlz.2_Missense_Mutation_p.S292F|FDXR_uc002jmb.2_RNA	NM_024417	NP_077728	P22570	ADRO_HUMAN	ferredoxin reductase isoform 1 precursor	300					cholesterol metabolic process|electron transport chain|steroid biosynthetic process|transport	mitochondrial matrix	ferredoxin-NADP+ reductase activity|protein binding				0	all_lung(278;0.172)|Lung NSC(278;0.207)					CCAGGCACGGGAGGCCGATGC	0.692		NaN											0	0	0	0.00623	0	35	41									
CDK3	1018	broad.mit.edu	37	17	73998377	73998377	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:73998377C>T	uc010dgt.2	+	5	440	c.364C>T	c.(364-366)CGG>TGG	p.R122W	CDK3_uc002jqg.3_Missense_Mutation_p.R150W	NM_001258	NP_001249	Q00526	CDK3_HUMAN	cyclin-dependent kinase 3	122	Protein kinase.				cell division|cell proliferation|mitosis		ATP binding|cyclin-dependent protein kinase activity			central_nervous_system(1)	1						CCACTCACATCGGGTCATCCA	0.627		NaN											0	0	0	0.00361	0	77	82									
UBE2O	63893	broad.mit.edu	37	17	74396299	74396299	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:74396299C>T	uc002jrm.3	-	8	1149	c.1084G>A	c.(1084-1086)GAG>AAG	p.E362K	UBE2O_uc002jrn.3_Missense_Mutation_p.E362K|UBE2O_uc002jrl.3_5'Flank	NM_022066	NP_071349	Q9C0C9	UBE2O_HUMAN	ubiquitin-conjugating enzyme E2O	362							ATP binding|ubiquitin-protein ligase activity			breast(2)|skin(2)|lung(1)	5						TTGGCTGGCTCTACCTTGGCT	0.582		NaN											0	0	0	0.00361	0	53	84									
NPTX1	4884	broad.mit.edu	37	17	78449360	78449360	+	Silent	SNP	G	G	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:78449360G>T	uc002jyp.1	-	2	761	c.603C>A	c.(601-603)ATC>ATA	p.I201I		NM_002522	NP_002513	Q15818	NPTX1_HUMAN	neuronal pentraxin I precursor	201					central nervous system development|synaptic transmission|transport	transport vesicle	metal ion binding				0	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0487)			GGGCGGTCTCGATCTTGACCC	0.667		NaN											1	0	1.90571e-15	0.004289	2.01907e-15	32	53									
TMEM105	284186	broad.mit.edu	37	17	79287597	79287597	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:79287597G>A	uc002kad.1	-	3	794	c.244C>T	c.(244-246)CGA>TGA	p.R82*		NM_178520	NP_848615	Q8N8V8	TM105_HUMAN	transmembrane protein 105	82						integral to membrane				ovary(1)	1	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.0892)			TCATGTCTTCGCCTTCTTATC	0.662		NaN											0	0	0	0.00361	0	133	116									
CEP192	55125	broad.mit.edu	37	18	13092445	13092445	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr18:13092445C>T	uc010xac.1	+	34	6253	c.6173C>T	c.(6172-6174)TCA>TTA	p.S2058L	CEP192_uc010dlf.1_RNA|CEP192_uc010xad.1_Missense_Mutation_p.S1583L|CEP192_uc002kru.2_RNA|CEP192_uc002krv.2_Missense_Mutation_p.S480L|CEP192_uc002krw.2_Missense_Mutation_p.S207L|CEP192_uc002krx.2_Missense_Mutation_p.S62L|CEP192_uc002kry.2_RNA	NM_032142	NP_115518	E9PF99	E9PF99_HUMAN	centrosomal protein 192kDa	2058										ovary(4)|pancreas(1)	5						ATTATACTTTCAGTAATTGGA	0.333		NaN											0	0	0	0.010729	0	12	49									
ROCK1	6093	broad.mit.edu	37	18	18625257	18625257	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr18:18625257G>A	uc002kte.2	-	5	1527	c.586C>T	c.(586-588)CAC>TAC	p.H196Y		NM_005406	NP_005397	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein	196	Protein kinase.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|breast(2)|central_nervous_system(1)	5	Melanoma(1;0.165)					CTTTACCTGTGAATAAAACCC	0.343		NaN											0	0	0	0.00308	0	6	31									
ZNF521	25925	broad.mit.edu	37	18	22806745	22806745	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr18:22806745C>T	uc002kvk.2	-	4	1384	c.1137G>A	c.(1135-1137)AAG>AAA	p.K379K	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Silent_p.K379K|ZNF521_uc002kvl.2_Silent_p.K159K	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	379					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					TCCCTCGACTCTTTGGGATTG	0.532		NaN	T	PAX5	ALL								0	0	0	0.007291	0	20	77									
SS18	6760	broad.mit.edu	37	18	23612474	23612474	+	Silent	SNP	A	A	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr18:23612474A>T	uc002kvm.2	-	10	1197	c.1119T>A	c.(1117-1119)GGT>GGA	p.G373G	SS18_uc002kvn.2_Silent_p.G342G|SS18_uc010xbf.1_Silent_p.G291G|SS18_uc010xbg.1_Silent_p.G290G|SS18_uc010xbh.1_Silent_p.G290G|SS18_uc010xbi.1_Silent_p.G350G	NM_001007559	NP_001007560	Q15532	SSXT_HUMAN	synovial sarcoma translocation, chromosome 18	373	Gln-rich.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	ligand-dependent nuclear receptor transcription coactivator activity|protein binding		SS18/SSX1(1169)|SS18/SSX2(702)|SS18/SSX4(12)	soft_tissue(1883)|ovary(1)	1884	all_cancers(21;0.000194)|Lung NSC(5;0.000413)|all_lung(6;0.00118)|Ovarian(20;0.124)					GATACTGAGGACCTGGACCAC	0.493		NaN	T	SSX1| SSX2	synovial sarcoma								0	0	0	0.003954	0	22	57									
GALNT1	2589	broad.mit.edu	37	18	33243615	33243615	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr18:33243615C>T	uc010dmu.2	+	3	216	c.163C>T	c.(163-165)CAT>TAT	p.H55Y	GALNT1_uc002kyz.3_5'UTR|GALNT1_uc002kza.2_Missense_Mutation_p.H55Y|GALNT1_uc002kzb.2_Missense_Mutation_p.H55Y	NM_020474	NP_065207	Q10472	GALT1_HUMAN	polypeptide N-acetylgalactosaminyltransferase 1	55	Lumenal (Potential).				protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2						ACAAAAGCCTCATGAAGGTCC	0.328		NaN											0	0	0	0.003163	0	12	13									
KIAA0427	9811	broad.mit.edu	37	18	46287980	46287980	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr18:46287980G>A	uc002ldc.2	+	9	1576	c.1291G>A	c.(1291-1293)GCT>ACT	p.A431T	KIAA0427_uc002ldd.2_Missense_Mutation_p.A433T|KIAA0427_uc002lde.3_Missense_Mutation_p.A60T	NM_014772	NP_055587	O43310	CTIF_HUMAN	hypothetical protein LOC9811 isoform 1	431	MIF4G.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational initiation	perinuclear region of cytoplasm	protein binding				0						CGCCTTCACCGCTGCCAAGCT	0.617		NaN											0	0	0	0.007835	0	35	100									
LIPG	9388	broad.mit.edu	37	18	47101864	47101864	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr18:47101864C>T	uc002ldv.2	+	5	949	c.697C>T	c.(697-699)CAG>TAG	p.Q233*	LIPG_uc002ldu.1_Nonsense_Mutation_p.Q233*|LIPG_uc010xdh.1_Intron	NM_006033	NP_006024	Q9Y5X9	LIPE_HUMAN	endothelial lipase precursor	233					cholesterol homeostasis|high-density lipoprotein particle remodeling|phospholipid catabolic process|phospholipid homeostasis|positive regulation of cholesterol transport|positive regulation of high-density lipoprotein particle clearance|reverse cholesterol transport	extracellular space	heparin binding|lipoprotein lipase activity|phospholipase A1 activity|protein binding|triglyceride lipase activity			ovary(1)|skin(1)	2						CATTGGTATTCAGATGCCTGT	0.532		NaN											0	0	0	0.007835	0	37	51									
CCDC11	220136	broad.mit.edu	37	18	47777950	47777950	+	Silent	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr18:47777950C>G	uc002lee.2	-	4	769	c.678G>C	c.(676-678)CTG>CTC	p.L226L		NM_145020	NP_659457	Q96M91	CCD11_HUMAN	coiled-coil domain containing 11	226	Potential.									ovary(1)|pancreas(1)|skin(1)	3				STAD - Stomach adenocarcinoma(97;2.66e-05)|Colorectal(21;7.57e-05)|Lung(128;0.00932)|READ - Rectum adenocarcinoma(32;0.164)		TGTTCTCCATCAGCTCTTTCT	0.552		NaN											0	0	0	0.00623	0	36	63									
SOCS6	9306	broad.mit.edu	37	18	67992252	67992252	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr18:67992252G>A	uc002lkr.1	+	2	664	c.348G>A	c.(346-348)GTG>GTA	p.V116V	SOCS6_uc010dqq.2_Silent_p.V116V	NM_004232	NP_004223	O14544	SOCS6_HUMAN	suppressor of cytokine signaling 6	116					defense response|JAK-STAT cascade|negative regulation of signal transduction|regulation of growth	cytoplasm				large_intestine(1)|lung(1)	2		Esophageal squamous(42;0.129)|Colorectal(73;0.152)				TTAAAGACGTGAGAGCTCAGA	0.597		NaN											0	0	0	0.010504	0	19	54									
SHC2	25759	broad.mit.edu	37	19	418997	418997	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:418997C>G	uc002loq.3	-	12	1680	c.1680G>C	c.(1678-1680)CAG>CAC	p.Q560H	SHC2_uc002lop.3_Missense_Mutation_p.Q301H	NM_012435	NP_036567	P98077	SHC2_HUMAN	SHC (Src homology 2 domain containing)	560	SH2.				insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol					0		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTGCCCGTTCTGCAGGTGGT	0.677		NaN											0	0	0	0.001168	0	6	7									
POLRMT	5442	broad.mit.edu	37	19	619263	619263	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:619263G>A	uc002lpf.1	-	14	3156	c.3100C>T	c.(3100-3102)CGC>TGC	p.R1034C		NM_005035	NP_005026	O00411	RPOM_HUMAN	mitochondrial DNA-directed RNA polymerase	1034	Mediates interaction with TEFM.				transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			ovary(1)|pancreas(1)	2		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AAGACCTGGCGTACGAGATAG	0.637		NaN											0	0	0	0.000602	0	4	114									
CNN2	1265	broad.mit.edu	37	19	1037770	1037770	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:1037770G>C	uc002lqu.2	+	7	1164	c.801G>C	c.(799-801)CAG>CAC	p.Q267H	ABCA7_uc002lqw.3_5'Flank|CNN2_uc002lqv.2_Missense_Mutation_p.Q228H|CNN2_uc010xgb.1_Missense_Mutation_p.Q256H|CNN2_uc010xgc.1_Missense_Mutation_p.Q288H|ABCA7_uc010dsa.2_5'Flank	NM_004368	NP_004359	Q99439	CNN2_HUMAN	calponin 2 isoform a	267	Calponin-like 3.				actomyosin structure organization|cellular response to mechanical stimulus|regulation of actin filament-based process	cell-cell junction|stress fiber	actin binding|calmodulin binding				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGGCCGGCAGATATATGACC	0.662		NaN											0	0	0	0.00361	0	41	69									
MUM1	84939	broad.mit.edu	37	19	1360523	1360523	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:1360523G>C	uc010xgm.1	+	4	672	c.603G>C	c.(601-603)GAG>GAC	p.E201D	MUM1_uc010dsi.2_Missense_Mutation_p.E133D|MUM1_uc002lrz.2_Missense_Mutation_p.E202D|MUM1_uc002lsb.2_Missense_Mutation_p.E133D|MUM1_uc002lsc.1_Missense_Mutation_p.E133D			Q2TAK8	MUM1_HUMAN	SubName: Full=MUM1 protein;	201					chromatin organization|DNA repair	nucleus	nucleosome binding|protein binding				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCAAGATGAGAGTGGGTCCA	0.537		NaN									OREG0025088	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.006214	0	9	15									
LRRC8E	80131	broad.mit.edu	37	19	7964521	7964521	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:7964521C>T	uc002mir.2	+	3	1215	c.1114C>T	c.(1114-1116)CAG>TAG	p.Q372*		NM_025061	NP_079337	Q6NSJ5	LRC8E_HUMAN	leucine rich repeat containing 8 family, member	372						integral to membrane				lung(1)|pancreas(1)	2						CCTCATCGATCAGTACGACTC	0.572		NaN											0	0	0	0.010504	0	17	49									
TIMM44	10469	broad.mit.edu	37	19	7992542	7992542	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:7992542C>T	uc002miz.2	-	12	1241	c.1239G>A	c.(1237-1239)CCG>CCA	p.P413P	TIMM44_uc002mja.2_Silent_p.P153P|CTXN1_uc002miy.3_5'Flank	NM_006351	NP_006342	O43615	TIM44_HUMAN	translocase of inner mitochondrial membrane 44	413					protein targeting to mitochondrion	mitochondrial inner membrane presequence translocase complex|mitochondrial matrix	ATP binding|P-P-bond-hydrolysis-driven protein transmembrane transporter activity			ovary(1)	1						CCTCACTCACCGGGTCACCCT	0.627		NaN											0	0	0	0.00361	0	106	88									
DNM2	1785	broad.mit.edu	37	19	10934516	10934516	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:10934516G>A	uc002mps.1	+	17	1998	c.1834G>A	c.(1834-1836)GAC>AAC	p.D612N	DNM2_uc010dxk.2_Intron|DNM2_uc002mpt.1_Missense_Mutation_p.D612N|DNM2_uc002mpv.1_Missense_Mutation_p.D608N|DNM2_uc002mpu.1_Missense_Mutation_p.D608N|DNM2_uc010dxl.1_Missense_Mutation_p.D612N|DNM2_uc002mpw.2_Missense_Mutation_p.D341N|DNM2_uc002mpx.1_5'UTR	NM_001005361	NP_001005361	P50570	DYN2_HUMAN	dynamin 2 isoform 2	612	PH.				G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			central_nervous_system(2)|skin(2)|ovary(1)|breast(1)	6			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			CTCCCAGGAAGACGTGGACAG	0.667		NaN											0	0	0	0.00361	0	39	52									
DNM2	1785	broad.mit.edu	37	19	10934530	10934530	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:10934530G>C	uc002mps.1	+	17	2012	c.1848G>C	c.(1846-1848)TGG>TGC	p.W616C	DNM2_uc010dxk.2_Intron|DNM2_uc002mpt.1_Missense_Mutation_p.W616C|DNM2_uc002mpv.1_Missense_Mutation_p.W612C|DNM2_uc002mpu.1_Missense_Mutation_p.W612C|DNM2_uc010dxl.1_Missense_Mutation_p.W616C|DNM2_uc002mpw.2_Missense_Mutation_p.W345C|DNM2_uc002mpx.1_5'UTR	NM_001005361	NP_001005361	P50570	DYN2_HUMAN	dynamin 2 isoform 2	616	PH.				G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			central_nervous_system(2)|skin(2)|ovary(1)|breast(1)	6			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			TGGACAGCTGGAAGGCCTCGT	0.657		NaN											0	0	0	0.00361	0	30	49									
ZNF442	79973	broad.mit.edu	37	19	12474396	12474396	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:12474396G>C	uc002mtr.1	-	3	661	c.50C>G	c.(49-51)TCT>TGT	p.S17C	ZNF442_uc010xmk.1_Intron	NM_030824	NP_110451	Q9H7R0	ZN442_HUMAN	zinc finger protein 442	17					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(2)|breast(1)|kidney(1)	4						ATTAGTCTGAGAGTCAGGAAG	0.488		NaN											0	0	0	0.004482	0	8	140									
MAN2B1	4125	broad.mit.edu	37	19	12767436	12767436	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:12767436G>A	uc002mub.2	-	13	1669	c.1593C>T	c.(1591-1593)AGC>AGT	p.S531S	MAN2B1_uc010dyv.1_Silent_p.S530S	NM_000528	NP_000519	O00754	MA2B1_HUMAN	mannosidase, alpha, class 2B, member 1	531					protein deglycosylation	lysosome	alpha-mannosidase activity|zinc ion binding			ovary(4)|central_nervous_system(2)	6						AAACGCCTTCGCTGACCGGCA	0.602		NaN											0	0	0	0.00361	0	106	68									
CASP14	23581	broad.mit.edu	37	19	15164702	15164702	+	Silent	SNP	G	G	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:15164702G>T	uc010dzv.1	+	4	644	c.336G>T	c.(334-336)CTG>CTT	p.L112L	CASP14_uc002naf.2_Silent_p.L112L	NM_012114	NP_036246	P31944	CASPE_HUMAN	caspase 14 precursor	112					apoptosis|cell differentiation|epidermis development|proteolysis	cytoplasm|nucleus	cysteine-type endopeptidase activity			skin(2)|ovary(1)|lung(1)	4						TCGAGGCCCTGAACAACAAGA	0.562		NaN											1	0	3.11337e-16	0.002836	3.31456e-16	29	48									
CHERP	10523	broad.mit.edu	37	19	16652774	16652774	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:16652774C>G	uc002nei.1	-	2	180	c.106G>C	c.(106-108)GAG>CAG	p.E36Q	MED26_uc002nee.2_Intron|CHERP_uc002nej.2_Missense_Mutation_p.E4Q	NM_006387	NP_006378	Q8IWX8	CHERP_HUMAN	calcium homeostasis endoplasmic reticulum	36	SURP motif.				cellular calcium ion homeostasis|negative regulation of cell proliferation|nervous system development|RNA processing	endoplasmic reticulum|perinuclear region of cytoplasm	RNA binding			ovary(2)	2						TTCTGCTTCTCCATAGTCATC	0.532		NaN											0	0	0	0.00278	0	21	40									
CHERP	10523	broad.mit.edu	37	19	16653168	16653168	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:16653168C>G	uc002nei.1	-	1	96	c.22G>C	c.(22-24)GAT>CAT	p.D8H	MED26_uc002nee.2_Intron|CHERP_uc002nej.2_5'Flank	NM_006387	NP_006378	Q8IWX8	CHERP_HUMAN	calcium homeostasis endoplasmic reticulum	8					cellular calcium ion homeostasis|negative regulation of cell proliferation|nervous system development|RNA processing	endoplasmic reticulum|perinuclear region of cytoplasm	RNA binding			ovary(2)	2						GTCTCACCATCGGGGGGCAGC	0.726		NaN											0	0	0	0.004482	0	3	14									
MAP1S	55201	broad.mit.edu	37	19	17831750	17831750	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:17831750C>T	uc002nhe.1	+	2	133	c.124C>T	c.(124-126)CGG>TGG	p.R42W	MAP1S_uc010eaz.1_Intron|MAP1S_uc010eba.1_Missense_Mutation_p.R42W|MAP1S_uc002nhf.1_Intron|MAP1S_uc010xpv.1_Missense_Mutation_p.R16W	NM_018174	NP_060644	Q66K74	MAP1S_HUMAN	BPY2 interacting protein 1	42	Necessary for the microtubule-organizing center localization.				apoptosis|brain development|microtubule bundle formation|mitochondrion transport along microtubule|neuron projection morphogenesis	cytosol|dendrite|microtubule|neuronal cell body|nucleus|perinuclear region of cytoplasm|spindle|synapse	actin filament binding|beta-tubulin binding|DNA binding|microtubule binding			central_nervous_system(1)	1						ACCAGGCATCCGGTCTTGGGA	0.582		NaN											0	0	0	0.010729	0	8	128									
ZNF253	56242	broad.mit.edu	37	19	19990934	19990934	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:19990934G>A	uc002noj.2	+	3	297	c.205G>A	c.(205-207)GAG>AAG	p.E69K	ZNF253_uc002nok.2_Intron|ZNF253_uc002nol.2_Intron	NM_021047	NP_066385	O75346	ZN253_HUMAN	zinc finger protein 253	69	KRAB.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGAAAGACATGAGATGATTGC	0.373		NaN											0	0	0	0.001984	0	7	33									
ZNF253	56242	broad.mit.edu	37	19	19990939	19990939	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:19990939G>A	uc002noj.2	+	3	302	c.210G>A	c.(208-210)ATG>ATA	p.M70I	ZNF253_uc002nok.2_Intron|ZNF253_uc002nol.2_Intron	NM_021047	NP_066385	O75346	ZN253_HUMAN	zinc finger protein 253	70	KRAB.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GACATGAGATGATTGCCAAAC	0.373		NaN											0	0	0	0.001168	0	6	33									
ZNF493	284443	broad.mit.edu	37	19	21606279	21606279	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:21606279C>T	uc002npx.2	+	2	714	c.434C>T	c.(433-435)TCT>TTT	p.S145F	ZNF493_uc002npw.2_Missense_Mutation_p.S273F|ZNF493_uc002npy.2_Missense_Mutation_p.S145F	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	145	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TGTGGCACATCTTTCTACCAA	0.348		NaN											0	0	0	0.00499	0	16	3									
ZNF493	284443	broad.mit.edu	37	19	21607244	21607244	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:21607244C>T	uc002npx.2	+	2	1679	c.1399C>T	c.(1399-1401)CAT>TAT	p.H467Y	ZNF493_uc002npw.2_Missense_Mutation_p.H595Y|ZNF493_uc002npy.2_Missense_Mutation_p.H467Y	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	467	C2H2-type 16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CAAGATAATTCATACTGATAA	0.333		NaN											0	0	0	0.00308	0	7	1									
ZNF493	284443	broad.mit.edu	37	19	21607722	21607722	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:21607722C>T	uc002npx.2	+	2	2157	c.1877C>T	c.(1876-1878)TCA>TTA	p.S626L	ZNF493_uc002npw.2_Missense_Mutation_p.S754L|ZNF493_uc002npy.2_Missense_Mutation_p.S626L	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	626	C2H2-type 22.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AGGCGGTCTTCACATCTTAGT	0.373		NaN											0	0	0	0.004482	0	9	4									
ZNF493	284443	broad.mit.edu	37	19	21607760	21607760	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:21607760C>T	uc002npx.2	+	2	2195	c.1915C>T	c.(1915-1917)CAT>TAT	p.H639Y	ZNF493_uc002npw.2_Missense_Mutation_p.H767Y|ZNF493_uc002npy.2_Missense_Mutation_p.H639Y	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	639					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TATTGGAATTCATACTGAAGA	0.378		NaN											0	0	0	0.00245	0	12	6									
ZNF91	7644	broad.mit.edu	37	19	23544994	23544994	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:23544994C>G	uc002nre.2	-	4	900	c.787G>C	c.(787-789)GAG>CAG	p.E263Q	ZNF91_uc010xrj.1_Missense_Mutation_p.E231Q	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	263						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				TAGATTTTCTCTTTAGCACAG	0.378		NaN											0	0	0	0.002836	0	29	42									
ZNF536	9745	broad.mit.edu	37	19	30934886	30934886	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:30934886C>T	uc002nsu.1	+	2	555	c.417C>T	c.(415-417)TTC>TTT	p.F139F	ZNF536_uc010edd.1_Silent_p.F139F	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	139	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding	p.F139F(1)		ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GCAAGCGCTTCCGCTTCAACA	0.637		NaN											0	0	0	0.00361	0	207	50									
GPI	2821	broad.mit.edu	37	19	34884965	34884965	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:34884965C>T	uc002nvg.1	+	12	1159	c.1056C>T	c.(1054-1056)TTC>TTT	p.F352F	GPI_uc002nvf.2_Silent_p.F391F|GPI_uc010xrv.1_Silent_p.F363F|GPI_uc010xrw.1_Silent_p.F324F|GPI_uc010edl.1_Silent_p.F352F|GPI_uc002nvi.1_Silent_p.F15F	NM_000175	NP_000166	P06744	G6PI_HUMAN	glucose phosphate isomerase	352					angiogenesis|gluconeogenesis|glycolysis|hemostasis|humoral immune response	cytosol|extracellular space|nucleus|plasma membrane	cytokine activity|glucose-6-phosphate isomerase activity|growth factor activity			ovary(1)|kidney(1)	2	Esophageal squamous(110;0.162)					CTGCGTACTTCCAGCAGGTAC	0.577		NaN											0	0	0	0.00361	0	42	50									
ZNF585B	92285	broad.mit.edu	37	19	37676214	37676214	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:37676214C>G	uc002ofq.2	-	5	2479	c.2225G>C	c.(2224-2226)GGA>GCA	p.G742A	uc002ofp.1_5'Flank|ZNF585B_uc002ofr.1_Missense_Mutation_p.G556A	NM_152279	NP_689492	Q52M93	Z585B_HUMAN	zinc finger protein 585B	742					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GGGTTTGTCTCCAGTGTGTGT	0.478		NaN											0	0	0	0.001368	0	10	203									
SIPA1L3	23094	broad.mit.edu	37	19	38633219	38633219	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:38633219C>T	uc002ohk.2	+	12	3911	c.3402C>T	c.(3400-3402)GTC>GTT	p.V1134V		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	1134					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CTAGGCCTGTCAGCTTCCCAG	0.542		NaN									OREG0025445	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00361	0	337	316									
RYR1	6261	broad.mit.edu	37	19	39055650	39055650	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:39055650G>A	uc002oit.2	+	91	12806	c.12676G>A	c.(12676-12678)GAG>AAG	p.E4226K	RYR1_uc002oiu.2_Missense_Mutation_p.E4221K|RYR1_uc002oiv.1_Missense_Mutation_p.E1135K	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	4226					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CGAGGGCGGCGAGGCTGAGAA	0.642		NaN											0	0	0	0.003163	0	11	20									
ZNF780A	284323	broad.mit.edu	37	19	40580552	40580552	+	Missense_Mutation	SNP	T	T	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:40580552T>G	uc002omy.2	-	6	2022	c.1797A>C	c.(1795-1797)CAA>CAC	p.Q599H	ZNF780A_uc002omw.3_Intron|ZNF780A_uc002omz.2_Missense_Mutation_p.Q599H|ZNF780A_uc010xvh.1_Missense_Mutation_p.Q600H	NM_001010880	NP_001010880	O75290	Z780A_HUMAN	zinc finger protein 780A isoform b	599	C2H2-type 16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					GTCGAATAAGTTGCATATGAA	0.403		NaN											0	0	0	0.00308	0	6	211									
ZNF780A	284323	broad.mit.edu	37	19	40580582	40580582	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:40580582C>T	uc002omy.2	-	6	1992	c.1767G>A	c.(1765-1767)GAG>GAA	p.E589E	ZNF780A_uc002omw.3_Intron|ZNF780A_uc002omz.2_Silent_p.E589E|ZNF780A_uc010xvh.1_Silent_p.E590E	NM_001010880	NP_001010880	O75290	Z780A_HUMAN	zinc finger protein 780A isoform b	589	C2H2-type 16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					CTTTCCCACACTCCTTACATT	0.393		NaN											0	0	0	0.000602	0	4	251									
CYP2A6	1548	broad.mit.edu	37	19	41351241	41351241	+	Silent	SNP	T	T	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:41351241T>C	uc002opl.3	-	7	1140	c.1119A>G	c.(1117-1119)AGA>AGG	p.R373R	CYP2A6_uc010ehe.1_Silent_p.R169R	NM_000762	NP_000753	P11509	CP2A6_HUMAN	cytochrome P450, family 2, subfamily A,	373					coumarin catabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|enzyme binding|heme binding			ovary(2)	2			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)		Chlorzoxazone(DB00356)|Diethylstilbestrol(DB00255)|Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Formoterol(DB00983)|Halothane(DB01159)|Letrozole(DB01006)|Methoxsalen(DB00553)|Metyrapone(DB01011)|Nicotine(DB00184)|Pilocarpine(DB01085)|Tolbutamide(DB01124)|Tranylcypromine(DB00752)	CCTTTTTGACTCTGCGGGCCA	0.572		NaN											0	0	0	0.008291	0	5	270									
CIC	23152	broad.mit.edu	37	19	42796294	42796294	+	Silent	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:42796294G>C	uc002otf.1	+	12	2983	c.2943G>C	c.(2941-2943)CTG>CTC	p.L981L		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog	981	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)				TGCCGCCCCTGAGCCCAGCCA	0.652		NaN	T	DUX4	soft tissue sarcoma								0	0	0	0.00361	0	80	64									
ZNF230	7773	broad.mit.edu	37	19	44514657	44514657	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:44514657G>C	uc002oyb.1	+	5	717	c.466G>C	c.(466-468)GAT>CAT	p.D156H		NM_006300	NP_006291	Q9UIE0	ZN230_HUMAN	zinc finger protein 230	156	KRNB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)				TGCCATCTTTGATCCTCCTCA	0.453		NaN											0	0	0	0.00361	0	79	117									
ZNF223	7766	broad.mit.edu	37	19	44571265	44571265	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:44571265C>G	uc002oyf.1	+	5	1537	c.1284C>G	c.(1282-1284)TTC>TTG	p.F428L	ZNF284_uc010ejd.2_RNA	NM_013361	NP_037493	Q9UK11	ZN223_HUMAN	zinc finger protein 223	428	C2H2-type 10; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(69;0.0352)				AAAAACCATTCAAATGTGAGG	0.408		NaN											0	0	0	0.00361	0	60	66									
CEACAM19	56971	broad.mit.edu	37	19	45175238	45175238	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:45175238C>T	uc002ozo.3	+	1	515	c.35C>T	c.(34-36)TCA>TTA	p.S12L	CEACAM19_uc002ozp.3_Missense_Mutation_p.S12L	NM_020219	NP_064604	Q7Z692	CEA19_HUMAN	carcinoembryonic antigen-related cell adhesion	12						integral to membrane					0	Lung NSC(12;0.00308)|all_lung(12;0.00806)	Prostate(69;0.0376)				GGCTGCTTCTCAAAGAGCCTC	0.562		NaN											0	0	0	0.00499	0	12	17									
GIPR	2696	broad.mit.edu	37	19	46178078	46178078	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:46178078G>A	uc002pcu.1	+	7	726	c.627G>A	c.(625-627)TGG>TGA	p.W209*	GIPR_uc002pct.1_Nonsense_Mutation_p.W209*|GIPR_uc010xxp.1_Nonsense_Mutation_p.W173*|GIPR_uc010xxq.1_RNA|MIR642_hsa-mir-642|MI0003657_5'Flank	NM_000164	NP_000155	P48546	GIPR_HUMAN	gastric inhibitory polypeptide receptor	209	Extracellular (Potential).				generation of precursor metabolites and energy|response to nutrient	integral to membrane|plasma membrane				skin(1)	1		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0056)|GBM - Glioblastoma multiforme(486;0.0832)|Epithelial(262;0.199)		TTGCGCTGTGGAACCAGGTGG	0.577		NaN											0	0	0	0.004656	0	20	61									
TULP2	7288	broad.mit.edu	37	19	49392787	49392787	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:49392787C>T	uc002pkz.2	-	7	767	c.616G>A	c.(616-618)GAA>AAA	p.E206K		NM_003323	NP_003314	O00295	TULP2_HUMAN	tubby like protein 2	206					visual perception	cytoplasm|extracellular region				ovary(1)|kidney(1)|skin(1)	3		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000259)|all cancers(93;0.000435)|Epithelial(262;0.0221)|GBM - Glioblastoma multiforme(486;0.0234)		GCCAAGTTTTCATATACACAG	0.502		NaN											0	0	0	0.00361	0	65	135									
ZNF766	90321	broad.mit.edu	37	19	52785369	52785369	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:52785369C>T	uc002pyr.1	+	2	67	c.24C>T	c.(22-24)CAC>CAT	p.H8H	ZNF766_uc002pys.1_Silent_p.H8H|ZNF766_uc002pyt.1_Silent_p.H23H	NM_001010851	NP_001010851	Q5HY98	ZN766_HUMAN	zinc finger protein 766	8					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00236)|OV - Ovarian serous cystadenocarcinoma(262;0.00871)		TTTAGGGACACTTGACATTCA	0.438		NaN											0	0	0	0.00361	0	147	163									
ZNF480	147657	broad.mit.edu	37	19	52824897	52824897	+	Missense_Mutation	SNP	T	T	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:52824897T>A	uc010ydl.1	+	5	464	c.394T>A	c.(394-396)TTT>ATT	p.F132I	ZNF480_uc002pyv.2_Missense_Mutation_p.F55I|ZNF480_uc010ydm.1_Missense_Mutation_p.F89I|ZNF480_uc010epn.2_5'UTR|uc002pyw.1_Intron	NM_144684	NP_653285	Q8WV37	ZN480_HUMAN	zinc finger protein 480	132					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00212)|OV - Ovarian serous cystadenocarcinoma(262;0.00369)		TGGAGTATCCTTTCACTTACA	0.378		NaN											0	0	0	0.006122	0	14	78									
ZNF761	388561	broad.mit.edu	37	19	53959484	53959484	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:53959484G>C	uc010eqp.2	+	7	2181	c.1723G>C	c.(1723-1725)GAG>CAG	p.E575Q	ZNF761_uc010ydy.1_Missense_Mutation_p.E521Q|ZNF761_uc002qbt.1_Missense_Mutation_p.E521Q	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	575					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		TCATAGTGGAGAGAACCCTTA	0.383		NaN											0	0	0	0.010729	0	11	91									
USP29	57663	broad.mit.edu	37	19	57642777	57642777	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:57642777G>A	uc002qny.2	+	4	3090	c.2734G>A	c.(2734-2736)GAA>AAA	p.E912K		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	912					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CCCTCAGGGGGAATACGAAGG	0.468		NaN											0	0	0	0.00361	0	76	92									
ZNF544	27300	broad.mit.edu	37	19	58772798	58772799	+	Missense_Mutation	DNP	GG	GG	AT			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:58772798_58772799GG>AT	uc010euo.2	+	7	1300_1301	c.826_827GG>AT	c.(826-828)GGA>ATA	p.G276I	ZNF544_uc010yhw.1_Intron|ZNF544_uc010yhx.1_Missense_Mutation_p.G248I|ZNF544_uc010yhy.1_Missense_Mutation_p.G248I|ZNF544_uc002qrt.3_Missense_Mutation_p.G134I|ZNF544_uc002qru.3_Missense_Mutation_p.G134I|uc002qrx.1_Intron	NM_014480	NP_055295	Q6NX49	ZN544_HUMAN	zinc finger protein 544	276					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		all_cancers(17;4.17e-12)|all_epithelial(17;1.25e-08)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.17)|GBM - Glioblastoma multiforme(193;0.018)		TAAGGATTATGGAAACCTCTTC	0.411		NaN											0	0	0	0.004672	0	13	82									
LAPTM4A	9741	broad.mit.edu	37	2	20251207	20251207	+	Silent	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:20251207G>C	uc002rdm.2	-	1	583	c.75C>G	c.(73-75)GTC>GTG	p.V25V	LAPTM4A_uc002rdn.2_5'UTR|LAPTM4A_uc010yjx.1_Silent_p.V25V	NM_014713	NP_055528	Q15012	LAP4A_HUMAN	lysosomal protein transmembrane 4 alpha	25					transport	endomembrane system|Golgi apparatus|integral to membrane				ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCCCGGTGCGGACATGGCAAC	0.667		NaN											0	0	0	0.002299	0	17	16									
LAPTM4A	9741	broad.mit.edu	37	2	20251240	20251240	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:20251240G>A	uc002rdm.2	-	1	550	c.42C>T	c.(40-42)TTC>TTT	p.F14F	LAPTM4A_uc002rdn.2_5'UTR|LAPTM4A_uc010yjx.1_Silent_p.F14F	NM_014713	NP_055528	Q15012	LAP4A_HUMAN	lysosomal protein transmembrane 4 alpha	14					transport	endomembrane system|Golgi apparatus|integral to membrane				ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGGTGCTGTAGAACCGGTCAC	0.642		NaN											0	0	0	0.00499	0	13	15									
SDC1	6382	broad.mit.edu	37	2	20405149	20405149	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:20405149C>T	uc002rdo.1	-	2	402	c.103G>A	c.(103-105)GAT>AAT	p.D35N	SDC1_uc002rdp.1_Missense_Mutation_p.D35N|SDC1_uc010exv.2_Missense_Mutation_p.D35N|SDC1_uc010exw.1_RNA	NM_002997	NP_002988	P18827	SDC1_HUMAN	syndecan 1 precursor	35	Extracellular (Potential).				lipid metabolic process|lipoprotein metabolic process|myoblast development|striated muscle cell development	cytoplasm|extracellular region|focal adhesion|integral to plasma membrane	cytoskeletal protein binding|protein C-terminus binding			ovary(4)|skin(1)	5	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)			OV - Ovarian serous cystadenocarcinoma(76;0.221)		CCAGAGCCATCTTGATCTTCA	0.557		NaN											0	0	0	0.00361	0	50	114									
ASXL2	55252	broad.mit.edu	37	2	25990551	25990551	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:25990551G>A	uc002rgs.2	-	7	897	c.676C>T	c.(676-678)CAA>TAA	p.Q226*	ASXL2_uc002rgt.1_5'UTR	NM_018263	NP_060733	Q76L83	ASXL2_HUMAN	additional sex combs like 2	226	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTTGAGTTTTGAGGGCTGCCT	0.418		NaN											0	0	0	0.00361	0	77	12									
TMEM214	54867	broad.mit.edu	37	2	27260564	27260564	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:27260564G>A	uc002ria.3	+	9	1256	c.1146G>A	c.(1144-1146)AAG>AAA	p.K382K	TMEM214_uc010yle.1_RNA|TMEM214_uc002rib.3_Silent_p.K337K	NM_017727	NP_060197	Q6NUQ4	TM214_HUMAN	transmembrane protein 214 isoform 1	382						integral to membrane	protein binding				0						CTGAGATGAAGAAAGAGGTGA	0.547		NaN											0	0	0	0.004656	0	23	98									
EIF2AK2	5610	broad.mit.edu	37	2	37366873	37366873	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:37366873C>T	uc010ynh.1	-	6	974	c.417G>A	c.(415-417)CAG>CAA	p.Q139Q	EIF2AK2_uc010fab.1_Silent_p.Q139Q|EIF2AK2_uc010yng.1_Silent_p.Q139Q|EIF2AK2_uc010fac.2_Silent_p.Q139Q|EIF2AK2_uc010fad.2_Silent_p.Q139Q	NM_002759	NP_002750	P19525	E2AK2_HUMAN	eukaryotic translation initiation factor 2-alpha	139	DRBM 2.				evasion by virus of host immune response|modulation by virus of host cellular process|negative regulation of osteoblast proliferation|protein autophosphorylation|response to virus|viral infectious cycle	cytosol	ATP binding|double-stranded RNA binding|eukaryotic translation initiation factor 2alpha kinase activity|protein binding|protein phosphatase type 2A regulator activity			ovary(2)|lung(2)|pancreas(1)	5		all_hematologic(82;0.248)				TATATTCTTTCTGTCCCATTT	0.323		NaN											0	0	0	0.006214	0	8	41									
SOCS5	9655	broad.mit.edu	37	2	46986049	46986049	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:46986049C>T	uc002rvf.2	+	2	544	c.380C>T	c.(379-381)TCC>TTC	p.S127F	SOCS5_uc010yoe.1_Missense_Mutation_p.S96F|SOCS5_uc002rvg.2_Missense_Mutation_p.S127F	NM_014011	NP_054730	O75159	SOCS5_HUMAN	suppressor of cytokine signaling 5	127					cell growth|cytokine-mediated signaling pathway|intracellular signal transduction|negative regulation of signal transduction|negative regulation of T-helper 2 cell differentiation|positive regulation of T-helper 1 cell differentiation|regulation of growth					ovary(1)|lung(1)|central_nervous_system(1)	3		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			AAAAAACATTCCTGTTCTACA	0.443		NaN											0	0	0	0.007413	0	18	37									
FOXN2	3344	broad.mit.edu	37	2	48573386	48573386	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:48573386G>A	uc002rwh.1	+	3	348	c.33G>A	c.(31-33)AAG>AAA	p.K11K		NM_002158	NP_002149	P32314	FOXN2_HUMAN	T-cell leukemia virus enhancer factor	11					embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.0272)|LUSC - Lung squamous cell carcinoma(58;0.036)			CTCCAGATAAGAGAGCTGAAA	0.423		NaN											0	0	0	0.00361	0	76	15									
SPTBN1	6711	broad.mit.edu	37	2	54858547	54858547	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:54858547G>A	uc002rxu.2	+	16	3612	c.3363G>A	c.(3361-3363)ATG>ATA	p.M1121I	SPTBN1_uc002rxx.2_Missense_Mutation_p.M1108I	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	1121	Spectrin 8.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			ACCAGAAGATGAGGGACATGG	0.587		NaN											0	0	0	0.00361	0	75	130									
CCDC88A	55704	broad.mit.edu	37	2	55523009	55523009	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:55523009G>A	uc002ryv.2	-	31	6114	c.5272C>T	c.(5272-5274)CGA>TGA	p.R1758*	CCDC88A_uc010yoz.1_Nonsense_Mutation_p.R1731*|CCDC88A_uc010ypa.1_Intron|CCDC88A_uc002ryt.2_Nonsense_Mutation_p.R49*|CCDC88A_uc010fbw.2_Nonsense_Mutation_p.R260*|CCDC88A_uc002ryu.2_Nonsense_Mutation_p.R1013*|CCDC88A_uc002rys.2_Nonsense_Mutation_p.R716*|CCDC88A_uc002ryw.2_Nonsense_Mutation_p.R1042*|CCDC88A_uc010fby.1_Nonsense_Mutation_p.R610*	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	1759					activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						TCAGTTTTTCGAGGACCAGGT	0.438		NaN											0	0	0	0.00874	0	36	43									
SLC1A4	6509	broad.mit.edu	37	2	65217170	65217170	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:65217170C>T	uc010yqa.1	+	1	715	c.393C>T	c.(391-393)CTC>CTT	p.L131L	SLC1A4_uc010ypy.1_Intron|SLC1A4_uc010ypz.1_Intron|SLC1A4_uc010fcv.2_Silent_p.L131L	NM_003038	NP_003029	P43007	SATT_HUMAN	solute carrier family 1, member 4 isoform 1	131	Helical; (Potential).				cellular nitrogen compound metabolic process|cognition|synaptic transmission, glutamatergic	intermediate filament|melanosome	chloride channel activity|L-alanine transmembrane transporter activity|L-cystine transmembrane transporter activity|L-hydroxyproline transmembrane transporter activity|L-proline transmembrane transporter activity|L-serine transmembrane transporter activity|L-threonine transmembrane transporter activity|sodium:dicarboxylate symporter activity			pancreas(1)	1					L-Alanine(DB00160)	CCTCGGCGCTCGCCGTGGCCT	0.687		NaN											0	0	0	0.004656	0	21	3									
DYSF	8291	broad.mit.edu	37	2	71730410	71730410	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:71730410C>T	uc002sie.2	+	4	679	c.303C>T	c.(301-303)TTC>TTT	p.F101F	DYSF_uc010feg.2_Silent_p.F101F|DYSF_uc010feh.2_Silent_p.F101F|DYSF_uc002sig.3_Silent_p.F101F|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Silent_p.F101F|DYSF_uc010fef.2_Silent_p.F101F|DYSF_uc010fei.2_Silent_p.F101F|DYSF_uc010fek.2_Silent_p.F102F|DYSF_uc010fej.2_Silent_p.F102F|DYSF_uc010fel.2_Silent_p.F102F|DYSF_uc010feo.2_Silent_p.F102F|DYSF_uc010fem.2_Silent_p.F102F|DYSF_uc010fen.2_Silent_p.F102F|DYSF_uc002sif.2_Silent_p.F102F	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	101	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						CCGCCAGCTTCAATGCCCCCC	0.577		NaN											0	0	0	0.00361	0	219	31									
DYSF	8291	broad.mit.edu	37	2	71776507	71776507	+	Missense_Mutation	SNP	C	C	T	rs144931729	byFrequency	TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:71776507C>T	uc002sie.2	+	17	1884	c.1508C>T	c.(1507-1509)TCG>TTG	p.S503L	DYSF_uc010feg.2_Missense_Mutation_p.S534L|DYSF_uc010feh.2_Intron|DYSF_uc002sig.3_Intron|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.S503L|DYSF_uc010fef.2_Intron|DYSF_uc010fei.2_Intron|DYSF_uc010fek.2_Intron|DYSF_uc010fej.2_Intron|DYSF_uc010fel.2_Intron|DYSF_uc010feo.2_Missense_Mutation_p.S535L|DYSF_uc010fem.2_Missense_Mutation_p.S504L|DYSF_uc010fen.2_Intron|DYSF_uc002sif.2_Missense_Mutation_p.S504L	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	503	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						GTCAAGCCTTCGAAAGCCTCA	0.577		NaN											0	0	0	0.010771	0	36	6									
TET3	200424	broad.mit.edu	37	2	74326619	74326619	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:74326619C>T	uc002skb.3	+	8	3079	c.3079C>T	c.(3079-3081)CGG>TGG	p.R1027W		NM_144993	NP_659430	O43151	TET3_HUMAN	tet oncogene family member 3	1027							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						CTGCCGCCAGCGGCAGCTGGA	0.637		NaN											0	0	0	0.003954	0	19	15									
BOLA3	388962	broad.mit.edu	37	2	74369455	74369455	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:74369455C>G	uc002skc.1	-	3	240	c.202G>C	c.(202-204)GAA>CAA	p.E68Q	BOLA3_uc002skd.1_Intron	NM_212552	NP_997717	Q53S33	BOLA3_HUMAN	bolA-like 3 isoform 1	68						extracellular region					0						TCTTCTGATTCAATTTTAATT	0.423		NaN											0	0	0	0.010771	0	34	65									
MOGS	7841	broad.mit.edu	37	2	74689799	74689799	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:74689799C>G	uc010ffj.2	-	4	1280	c.1117G>C	c.(1117-1119)GAG>CAG	p.E373Q	MOGS_uc010ffh.2_Missense_Mutation_p.E98Q|MOGS_uc010yrt.1_Missense_Mutation_p.E254Q|MOGS_uc010ffi.2_Missense_Mutation_p.E267Q	NM_006302	NP_006293	Q13724	MOGS_HUMAN	mannosyl-oligosaccharide glucosidase isoform 1	373	Lumenal (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|membrane fraction	mannosyl-oligosaccharide glucosidase activity				0						AAGGTCTTCTCAAAGCGCTCT	0.587		NaN											0	0	0	0.010818	0	33	108									
MOGS	7841	broad.mit.edu	37	2	74689864	74689864	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:74689864C>G	uc010ffj.2	-	4	1215	c.1052G>C	c.(1051-1053)AGA>ACA	p.R351T	MOGS_uc010ffh.2_Missense_Mutation_p.R76T|MOGS_uc010yrt.1_Missense_Mutation_p.R232T|MOGS_uc010ffi.2_Missense_Mutation_p.R245T	NM_006302	NP_006293	Q13724	MOGS_HUMAN	mannosyl-oligosaccharide glucosidase isoform 1	351	Lumenal (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|membrane fraction	mannosyl-oligosaccharide glucosidase activity				0						GCCTGCCAGTCTTGGCAGGGC	0.532		NaN											0	0	0	0.00361	0	69	93									
TGOLN2	10618	broad.mit.edu	37	2	85554607	85554607	+	Missense_Mutation	SNP	T	T	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:85554607T>C	uc010fgd.1	-	2	537	c.248A>G	c.(247-249)AAG>AGG	p.K83R	TGOLN2_uc002soz.2_Missense_Mutation_p.K83R|TGOLN2_uc002spa.2_Intron|TGOLN2_uc002spb.2_Missense_Mutation_p.K83R|TGOLN2_uc002spc.1_Missense_Mutation_p.K83R	NM_006464	NP_006455	O43493	TGON2_HUMAN	trans-golgi network protein 2	83	Extracellular (Potential).|14 X 14 AA tandem repeats.|3.					integral to membrane|nucleus|plasma membrane|trans-Golgi network|transport vesicle	protein binding				0						CGCACCCGACTTGTTGGGGGT	0.602		NaN											0	0	0	0.004482	0	7	533									
REV1	51455	broad.mit.edu	37	2	100052376	100052376	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:100052376C>G	uc002tad.2	-	7	1453	c.1241G>C	c.(1240-1242)AGA>ACA	p.R414T	REV1_uc002tac.2_Missense_Mutation_p.R414T	NM_016316	NP_057400	Q9UBZ9	REV1_HUMAN	REV1-like isoform 1	414					DNA replication|error-prone translesion synthesis|response to UV	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|magnesium ion binding|protein binding			ovary(2)	2						GCTCTGATGTCTGGGAGAATT	0.348		NaN						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.00361	0	39	119									
NPAS2	4862	broad.mit.edu	37	2	101591943	101591943	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:101591943G>A	uc002tap.1	+	14	1592	c.1306G>A	c.(1306-1308)GAG>AAG	p.E436K	NPAS2_uc010yvt.1_Missense_Mutation_p.E501K|NPAS2_uc010fit.1_Missense_Mutation_p.E14K	NM_002518	NP_002509	Q99743	NPAS2_HUMAN	neuronal PAS domain protein 2	436					central nervous system development|positive regulation of transcription from RNA polymerase II promoter|rhythmic process	transcription factor complex	DNA binding|Hsp90 protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(3)|upper_aerodigestive_tract(1)	4						GCTGATGGCAGAGGCCAGCAC	0.577		NaN											0	0	0	0.00361	0	156	253									
C2orf29	55571	broad.mit.edu	37	2	101885518	101885518	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:101885518G>C	uc002taw.3	+	6	1337	c.1255G>C	c.(1255-1257)GAT>CAT	p.D419H		NM_017546	NP_060016	Q9UKZ1	CB029_HUMAN	hypothetical protein LOC55571	419					cell proliferation|nuclear-transcribed mRNA poly(A) tail shortening	cytosol				ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						TACAGCTGTTGATCTACCTCC	0.279		NaN											0	0	0	0.001168	0	5	24									
IMP4	92856	broad.mit.edu	37	2	131103254	131103254	+	Missense_Mutation	SNP	G	G	A	rs146322628	byFrequency	TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:131103254G>A	uc002tra.1	+	5	438	c.421G>A	c.(421-423)GAG>AAG	p.E141K		NM_033416	NP_219484	Q96G21	IMP4_HUMAN	IMP4, U3 small nucleolar ribonucleoprotein,	141	Brix.				rRNA processing|translation	nucleolus|ribonucleoprotein complex	aminoacyl-tRNA ligase activity|ATP binding|protein binding			central_nervous_system(2)	2	Colorectal(110;0.1)					GGTCGTTCACGAGCATCGGGG	0.667		NaN											0	0	0	0.00361	0	48	36									
FAM123C	205147	broad.mit.edu	37	2	131520411	131520411	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:131520411G>A	uc002trw.2	+	2	956	c.766G>A	c.(766-768)GAT>AAT	p.D256N	FAM123C_uc010fmv.2_Missense_Mutation_p.D256N|FAM123C_uc010fms.1_Missense_Mutation_p.D256N|FAM123C_uc010fmt.1_Missense_Mutation_p.D256N|FAM123C_uc010fmu.1_Missense_Mutation_p.D256N	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	256										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		GGTGTTCGCAGATGAGAGCTC	0.647		NaN											0	0	0	0.00361	0	58	54									
LRP1B	53353	broad.mit.edu	37	2	141625324	141625324	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:141625324G>C	uc002tvj.1	-	27	5386	c.4414C>G	c.(4414-4416)CCC>GCC	p.P1472A	LRP1B_uc010fnl.1_Missense_Mutation_p.P654A	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1472	Extracellular (Potential).|LDL-receptor class B 12.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ACAGCAAAGGGATGGGAAAGG	0.428		NaN								TSP Lung(27;0.18)			0	0	0	0.009096	0	4	78									
NEB	4703	broad.mit.edu	37	2	152468805	152468805	+	Silent	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:152468805C>G	uc010fnx.2	-	74	11162	c.10971G>C	c.(10969-10971)CTG>CTC	p.L3657L		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	3657	Nebulin 100.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TCCTGTCACTCAGGATTTCTC	0.473		NaN											0	0	0	0.00361	0	49	6									
HOXD13	3239	broad.mit.edu	37	2	176958267	176958267	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:176958267G>A	uc002ukf.1	+	1	736	c.649G>A	c.(649-651)GAG>AAG	p.E217K		NM_000523	NP_000514	P35453	HXD13_HUMAN	homeobox D13	217					skeletal system development|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding			lung(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0526)|READ - Rectum adenocarcinoma(9;0.0678)		CGGCTCCGGGGAGCCTCGGCA	0.617		NaN	T	NUP98	AML*								0	0	0	0.00361	0	67	12									
COL5A2	1290	broad.mit.edu	37	2	189931201	189931201	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:189931201G>A	uc002uqk.2	-	23	1753	c.1478C>T	c.(1477-1479)CCG>CTG	p.P493L	COL5A2_uc010frx.2_Intron	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	493					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			TGGGCCTATCGGACCCTGAAT	0.478		NaN											0	0	0	0.00361	0	51	136									
AOX1	316	broad.mit.edu	37	2	201469496	201469496	+	Silent	SNP	G	G	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:201469496G>T	uc002uvx.2	+	9	848	c.747G>T	c.(745-747)CTG>CTT	p.L249L		NM_001159	NP_001150	Q06278	ADO_HUMAN	aldehyde oxidase 1	249	FAD-binding PCMH-type.				inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			ovary(4)|pancreas(1)|skin(1)	6					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	CCGTGACCCTGAAGGAACTGC	0.448		NaN											1	0	3.27315e-48	0.00361	3.59501e-48	85	41									
ICOS	29851	broad.mit.edu	37	2	204820542	204820542	+	Missense_Mutation	SNP	A	A	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:204820542A>T	uc002vam.2	+	2	309	c.242A>T	c.(241-243)AAA>ATA	p.K81I	ICOS_uc010zip.1_Missense_Mutation_p.K81I|ICOS_uc010fua.2_Missense_Mutation_p.K81I	NM_012092	NP_036224	Q9Y6W8	ICOS_HUMAN	inducible T-cell co-stimulator precursor	81	Ig-like V-type.|Extracellular (Potential).				immune response|T cell costimulation	extracellular region					0						AAGAGTCTGAAATTCTGCCAT	0.388		NaN											0	0	0	0.010818	0	29	63									
ICOS	29851	broad.mit.edu	37	2	204820544	204820544	+	Missense_Mutation	SNP	T	T	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:204820544T>C	uc002vam.2	+	2	311	c.244T>C	c.(244-246)TTC>CTC	p.F82L	ICOS_uc010zip.1_Missense_Mutation_p.F82L|ICOS_uc010fua.2_Missense_Mutation_p.F82L	NM_012092	NP_036224	Q9Y6W8	ICOS_HUMAN	inducible T-cell co-stimulator precursor	82	Ig-like V-type.|Extracellular (Potential).				immune response|T cell costimulation	extracellular region					0						GAGTCTGAAATTCTGCCATTC	0.388		NaN											0	0	0	0.010818	0	28	61									
BARD1	580	broad.mit.edu	37	2	215645993	215645993	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:215645993G>C	uc002veu.2	-	4	740	c.605C>G	c.(604-606)TCT>TGT	p.S202C	BARD1_uc010zjm.1_Missense_Mutation_p.S58C	NM_000465	NP_000456	Q99728	BARD1_HUMAN	BRCA1 associated RING domain 1	202					cell cycle arrest|DNA repair|negative regulation of apoptosis|negative regulation of mRNA 3'-end processing|negative regulation of protein export from nucleus|positive regulation of apoptosis|positive regulation of protein catabolic process|protein K6-linked ubiquitination|regulation of phosphorylation|tissue homeostasis	BRCA1-A complex|BRCA1-BARD1 complex|cytoplasm	kinase binding|protein heterodimerization activity|protein homodimerization activity|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)	2		Renal(323;0.0243)		Epithelial(149;3.2e-06)|all cancers(144;0.000461)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		CTTTTTTCCAGATCTTGCAGA	0.368		NaN							Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				0	0	0	0.001984	0	7	15									
OBSL1	23363	broad.mit.edu	37	2	220432452	220432452	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:220432452G>A	uc010fwk.2	-	3	1579	c.1522C>T	c.(1522-1524)CTC>TTC	p.L508F	OBSL1_uc010fwl.1_5'Flank|OBSL1_uc002vmi.2_Missense_Mutation_p.L508F|OBSL1_uc002vmj.2_Missense_Mutation_p.L95F	NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	508					cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		TTTACTCTGAGAAGCGTAGTG	0.597		NaN											0	0	0	0.005443	0	22	66									
MFF	56947	broad.mit.edu	37	2	228205033	228205033	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:228205033G>C	uc002vos.2	+	6	873	c.455G>C	c.(454-456)AGA>ACA	p.R152T	MFF_uc002vot.2_Missense_Mutation_p.R126T|MFF_uc002vou.2_Missense_Mutation_p.R152T|MFF_uc002vov.2_Missense_Mutation_p.R126T|MFF_uc002vow.2_Missense_Mutation_p.R126T|MFF_uc002vox.2_Missense_Mutation_p.R126T|MFF_uc002voy.2_Missense_Mutation_p.R152T|MFF_uc002voz.2_Missense_Mutation_p.R126T	NM_020194	NP_064579	Q9GZY8	MFF_HUMAN	mitochondrial fission factor	152	Cytoplasmic (Potential).					integral to membrane|mitochondrial outer membrane				large_intestine(1)	1						AGACTAAAAAGAGAGCGGTCT	0.413		NaN											0	0	0	0.00874	0	28	18									
USP40	55230	broad.mit.edu	37	2	234386116	234386116	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:234386116G>A	uc010zmr.1	-	31	3666	c.3666C>T	c.(3664-3666)ATC>ATT	p.I1222I	USP40_uc002vul.2_Silent_p.I206I	NM_018218	NP_060688	Q9NVE5	UBP40_HUMAN	ubiquitin thioesterase 40	1210					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(1)|lung(1)|breast(1)	3		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0539)		Epithelial(121;1.71e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000407)|Lung(119;0.00277)|LUSC - Lung squamous cell carcinoma(224;0.00646)		CACTGGAGAGGATGTAGCTGC	0.602		NaN											0	0	0	0.006122	0	15	45									
IDH3B	3420	broad.mit.edu	37	20	2639436	2639436	+	Missense_Mutation	SNP	G	G	C	rs140692628		TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr20:2639436G>C	uc002wgp.2	-	12	1128	c.1119C>G	c.(1117-1119)ATC>ATG	p.I373M	IDH3B_uc002wgq.2_Intron|IDH3B_uc002wgr.2_Missense_Mutation_p.I221M	NM_006899	NP_008830	O43837	IDH3B_HUMAN	isocitrate dehydrogenase 3, beta subunit isoform	373					isocitrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	electron carrier activity|isocitrate dehydrogenase (NAD+) activity|magnesium ion binding|NAD binding				0					NADH(DB00157)	TGACAGACTTGATGAAGTCGG	0.552		NaN											0	0	0	0.00874	0	31	45									
IDH3B	3420	broad.mit.edu	37	20	2640753	2640753	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr20:2640753G>C	uc002wgp.2	-	9	847	c.838C>G	c.(838-840)CTG>GTG	p.L280V	IDH3B_uc002wgq.2_Missense_Mutation_p.L280V|IDH3B_uc002wgr.2_Missense_Mutation_p.L128V	NM_006899	NP_008830	O43837	IDH3B_HUMAN	isocitrate dehydrogenase 3, beta subunit isoform	280					isocitrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	electron carrier activity|isocitrate dehydrogenase (NAD+) activity|magnesium ion binding|NAD binding				0					NADH(DB00157)	CCAGCAGCCAGATTGTCAATA	0.517		NaN											0	0	0	0.009718	0	38	55									
SEC23B	10483	broad.mit.edu	37	20	18535017	18535017	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr20:18535017G>A	uc002wqz.1	+	18	2574	c.2131G>A	c.(2131-2133)GAG>AAG	p.E711K	SEC23B_uc002wra.1_Missense_Mutation_p.E711K|SEC23B_uc002wrb.1_Missense_Mutation_p.E711K|SEC23B_uc010zsb.1_Missense_Mutation_p.E693K|SEC23B_uc002wrc.1_Missense_Mutation_p.E711K	NM_006363	NP_006354	Q15437	SC23B_HUMAN	Sec23 homolog B	711					ER to Golgi vesicle-mediated transport|intracellular protein transport	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane	zinc ion binding			ovary(1)	1						CATCAACACGGAGCATGGAGG	0.458		NaN											0	0	0	0.00361	0	78	63									
C20orf26	26074	broad.mit.edu	37	20	20177385	20177385	+	Missense_Mutation	SNP	T	T	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr20:20177385T>G	uc002wru.2	+	16	1838	c.1762T>G	c.(1762-1764)TAC>GAC	p.Y588D	C20orf26_uc010zse.1_Missense_Mutation_p.Y568D	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	588										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		ATCCTGTCTCTACTACCGTGT	0.473		NaN											0	0	0	0.010504	0	18	56									
C20orf26	26074	broad.mit.edu	37	20	20257987	20257987	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr20:20257987G>C	uc002wru.2	+	22	2757	c.2681G>C	c.(2680-2682)GGA>GCA	p.G894A	C20orf26_uc010zse.1_Missense_Mutation_p.G874A|C20orf26_uc002wrw.2_RNA	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	894										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		GGAGCCGCCGGAGTCACTATG	0.652		NaN											0	0	0	0.007291	0	28	58									
ENTPD6	955	broad.mit.edu	37	20	25203528	25203528	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr20:25203528G>C	uc002wuj.2	+	12	1280	c.1100G>C	c.(1099-1101)AGA>ACA	p.R367T	ENTPD6_uc010zsz.1_Missense_Mutation_p.R149T|ENTPD6_uc002wum.2_Missense_Mutation_p.R350T|ENTPD6_uc010zta.1_Missense_Mutation_p.R367T|ENTPD6_uc002wun.2_Missense_Mutation_p.R333T|ENTPD6_uc002wuk.2_Missense_Mutation_p.R366T|ENTPD6_uc002wul.2_Missense_Mutation_p.R366T|ENTPD6_uc010ztb.1_Missense_Mutation_p.R339T|ENTPD6_uc010ztc.1_Missense_Mutation_p.R339T|ENTPD6_uc002wuo.2_Missense_Mutation_p.R119T|ENTPD6_uc010ztd.1_Missense_Mutation_p.R115T|ENTPD6_uc010gdk.1_RNA|ENTPD6_uc010gdl.1_RNA	NM_001247	NP_001238	O75354	ENTP6_HUMAN	ectonucleoside triphosphate diphosphohydrolase 6	367	Lumenal (Potential).					Golgi membrane|integral to membrane	nucleoside-diphosphatase activity				0						CTTCAAAACAGAGTGCACAGG	0.582		NaN											0	0	0	0.00361	0	116	65									
NINL	22981	broad.mit.edu	37	20	25459797	25459797	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr20:25459797C>T	uc002wux.1	-	16	2037	c.1963G>A	c.(1963-1965)GAG>AAG	p.E655K	NINL_uc010gdn.1_Missense_Mutation_p.E655K|NINL_uc010gdo.1_Missense_Mutation_p.E438K	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	655	Potential.				G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						CTCTCCTTCTCAAAGTTCCTT	0.537		NaN											0	0	0	0.00333	0	19	71									
CBFA2T2	9139	broad.mit.edu	37	20	32210977	32210977	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr20:32210977G>C	uc002wzg.1	+	6	1131	c.594G>C	c.(592-594)CAG>CAC	p.Q198H	CBFA2T2_uc010zug.1_5'UTR|CBFA2T2_uc002wze.1_Missense_Mutation_p.Q189H|CBFA2T2_uc002wzf.1_RNA|CBFA2T2_uc002wzh.1_Missense_Mutation_p.Q169H|CBFA2T2_uc002wzi.1_RNA|CBFA2T2_uc002wzj.1_RNA	NM_005093	NP_005084	O43439	MTG8R_HUMAN	core-binding factor, runt domain, alpha subunit	198	TAFH.					nucleus	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)|skin(1)	2						CGGCCAAGCAGACCCCATCCC	0.582		NaN											0	0	0	0.004289	0	32	129									
NCOA6	23054	broad.mit.edu	37	20	33364229	33364229	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr20:33364229C>T	uc002xav.2	-	5	2829	c.258G>A	c.(256-258)CAG>CAA	p.Q86Q	NCOA6_uc002xaw.2_Silent_p.Q86Q|NCOA6_uc010gew.1_Silent_p.Q86Q	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	86	TBP/GTF2A-binding region.|NCOA1-binding region.|CREBBP-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						GCTCCACCTTCTGTACTTTTA	0.453		NaN											0	0	0	0.00278	0	19	51									
UQCC	55245	broad.mit.edu	37	20	33891825	33891825	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr20:33891825C>T	uc002xcd.2	-	10	880	c.813G>A	c.(811-813)GGG>GGA	p.G271G	UQCC_uc010zuy.1_Silent_p.G172G|UQCC_uc010zuz.1_Silent_p.G116G|UQCC_uc010zva.1_Silent_p.G134G|UQCC_uc002xce.2_Silent_p.G244G|UQCC_uc002xcg.2_Silent_p.G137G|UQCC_uc010gfb.2_Silent_p.G245G|UQCC_uc010zvb.1_Silent_p.G203G|UQCC_uc002xcf.2_Silent_p.G159G|UQCC_uc002xch.2_RNA|UQCC_uc002xcc.2_Silent_p.G84G	NM_018244	NP_060714	Q9NVA1	UQCC_HUMAN	basic FGF-repressed Zic binding protein isoform	271						cytoplasmic membrane-bounded vesicle				breast(1)	1			BRCA - Breast invasive adenocarcinoma(18;0.00252)			AGCTCACCTCCCCTGTCAGAA	0.592		NaN									OREG0025888	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00361	0	71	53									
CHD6	84181	broad.mit.edu	37	20	40127937	40127937	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr20:40127937C>T	uc002xka.1	-	6	1091	c.913G>A	c.(913-915)GAG>AAG	p.E305K	CHD6_uc002xkd.2_Missense_Mutation_p.E283K|CHD6_uc002xkc.2_Missense_Mutation_p.E340K	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	305	Chromo 1.				chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				CCACCAACCTCCTGGACAGTC	0.403		NaN											0	0	0	0.006122	0	13	5									
TOX2	84969	broad.mit.edu	37	20	42694696	42694696	+	Silent	SNP	C	C	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr20:42694696C>A	uc002xlf.3	+	6	1268	c.1251C>A	c.(1249-1251)CCC>CCA	p.P417P	TOX2_uc010ggo.2_Silent_p.P435P|TOX2_uc002xle.3_Silent_p.P393P|TOX2_uc010ggp.2_Silent_p.P393P|TOX2_uc002xlg.2_Intron|TOX2_uc010zwk.1_Silent_p.P313P	NM_001098798	NP_001092268	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	417	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			TGCCCACCCCCATGGCACTCC	0.677		NaN											1	0	2.47907e-22	0.00361	2.6826e-22	48	25									
ZMYND8	23613	broad.mit.edu	37	20	45875047	45875047	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr20:45875047C>G	uc002xta.1	-	14	2183	c.1929G>C	c.(1927-1929)GAG>GAC	p.E643D	ZMYND8_uc010ghq.1_Missense_Mutation_p.E320D|ZMYND8_uc010ghr.1_Missense_Mutation_p.E618D|ZMYND8_uc002xst.1_Missense_Mutation_p.E571D|ZMYND8_uc002xsu.1_Missense_Mutation_p.E643D|ZMYND8_uc002xsv.1_Missense_Mutation_p.E571D|ZMYND8_uc002xsw.1_Missense_Mutation_p.E395D|ZMYND8_uc002xsx.1_Missense_Mutation_p.E395D|ZMYND8_uc002xsy.1_Missense_Mutation_p.E618D|ZMYND8_uc002xsz.1_Missense_Mutation_p.E580D|ZMYND8_uc010zxy.1_Missense_Mutation_p.E670D|ZMYND8_uc002xtb.1_Missense_Mutation_p.E663D|ZMYND8_uc002xss.2_Missense_Mutation_p.E643D|ZMYND8_uc010zxz.1_Missense_Mutation_p.E638D|ZMYND8_uc002xtc.1_Missense_Mutation_p.E663D|ZMYND8_uc002xtd.1_Missense_Mutation_p.E638D|ZMYND8_uc002xte.1_Missense_Mutation_p.E643D|ZMYND8_uc010zya.1_Missense_Mutation_p.E643D|ZMYND8_uc002xtf.1_Missense_Mutation_p.E663D|ZMYND8_uc002xtg.2_Missense_Mutation_p.E637D|ZMYND8_uc010ghs.1_Missense_Mutation_p.E637D	NM_012408	NP_036540	Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8 isoform b	643							protein binding|zinc ion binding			central_nervous_system(2)|urinary_tract(1)|ovary(1)|skin(1)	5			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			CCTCTTTAATCTCCACTGGGT	0.512		NaN											0	0	0	0.00361	0	42	158									
PARD6B	84612	broad.mit.edu	37	20	49354553	49354553	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr20:49354553G>A	uc002xvo.2	+	2	469	c.226G>A	c.(226-228)GAT>AAT	p.D76N		NM_032521	NP_115910	Q9BYG5	PAR6B_HUMAN	PAR-6 beta	76	OPR.				axonogenesis|cell cycle|cell division|establishment or maintenance of cell polarity|protein complex assembly|regulation of cell migration|tight junction assembly	cytosol|tight junction	protein binding			kidney(1)	1						AAATAATGATGATAATTATCA	0.338		NaN											0	0	0	0.00361	0	41	22									
ZNF831	128611	broad.mit.edu	37	20	57768706	57768706	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr20:57768706G>A	uc002yan.2	+	1	2632	c.2632G>A	c.(2632-2634)GAG>AAG	p.E878K		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	878						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					GCAGGTGGGCGAGCCTCTGGA	0.657		NaN											0	0	0	0.007413	0	14	86									
CDH4	1002	broad.mit.edu	37	20	60509192	60509192	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr20:60509192G>C	uc002ybn.1	+	15	2472	c.2458G>C	c.(2458-2460)GAT>CAT	p.D820H	CDH4_uc002ybp.1_Missense_Mutation_p.D746H	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	820	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			GCGTCGCGTGGATGAGCGGCC	0.677		NaN											0	0	0	0.004007	0	11	74									
LAMA5	3911	broad.mit.edu	37	20	60921967	60921967	+	Splice_Site	SNP	A	A	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr20:60921967A>C	uc002ycq.2	-	7	1139	c.1072_splice	c.e7+1	p.S358_splice		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor						angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGAGGCACTCACACTGGCACT	0.687		NaN											0	0	0	0.007835	0	33	52									
CABLES2	81928	broad.mit.edu	37	20	60968519	60968519	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr20:60968519G>A	uc002ycv.2	-	6	864	c.857C>T	c.(856-858)TCG>TTG	p.S286L		NM_031215	NP_112492	Q9BTV7	CABL2_HUMAN	Cdk5 and Abl enzyme substrate 2	286					cell cycle|cell division|regulation of cell cycle|regulation of cell division		cyclin-dependent protein kinase regulator activity			pancreas(1)	1	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)			GGCTGGTGCCGACTTGGTGGG	0.637		NaN											0	0	0	0.00361	0	45	151									
RNF160	26046	broad.mit.edu	37	21	30339132	30339132	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr21:30339132C>G	uc002ymr.2	-	10	1832	c.1819G>C	c.(1819-1821)GAG>CAG	p.E607Q	RNF160_uc010gll.1_RNA	NM_015565	NP_056380	O94822	LTN1_HUMAN	zinc finger protein 294	561							ligase activity|zinc ion binding				0						TCAATCTTCTCTCCTTCTGAA	0.348		NaN											0	0	0	0.001855	0	13	7									
GRIK1	2897	broad.mit.edu	37	21	30934029	30934029	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr21:30934029C>G	uc002yno.1	-	15	2736	c.2272G>C	c.(2272-2274)GAG>CAG	p.E758Q	GRIK1_uc002ynn.2_Missense_Mutation_p.E743Q|GRIK1_uc011acs.1_Missense_Mutation_p.E758Q|GRIK1_uc011act.1_Missense_Mutation_p.E619Q	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	758	Extracellular (Potential).				central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	GTCACATACTCAATGCTGGTG	0.547		NaN											0	0	0	0.00361	0	48	31									
GRIK1	2897	broad.mit.edu	37	21	31066295	31066295	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr21:31066295C>T	uc002yno.1	-	2	670	c.206G>A	c.(205-207)CGA>CAA	p.R69Q	GRIK1_uc002ynn.2_Missense_Mutation_p.R69Q|GRIK1_uc011acs.1_Missense_Mutation_p.R69Q|GRIK1_uc011act.1_Intron|GRIK1_uc010glq.1_Intron|GRIK1_uc002ynr.2_Missense_Mutation_p.R69Q	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	69	Extracellular (Potential).				central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	CATCAGGGTTCGGTTTCTGTT	0.398		NaN											0	0	0	0.012213	0	26	71									
SON	6651	broad.mit.edu	37	21	34926321	34926321	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr21:34926321C>T	uc002yse.1	+	3	4833	c.4784C>T	c.(4783-4785)TCT>TTT	p.S1595F	SON_uc002ysb.1_Missense_Mutation_p.S1595F|SON_uc002ysc.2_Missense_Mutation_p.S1595F|SON_uc002ysd.2_Missense_Mutation_p.S586F|SON_uc002ysf.1_Intron|SON_uc002ysg.2_Missense_Mutation_p.S586F	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	1595					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6						ACTCTATCTTCTACTGGTCCT	0.413		NaN											0	0	0	0.007291	0	25	51									
SLC5A3	6526	broad.mit.edu	37	21	35468011	35468011	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr21:35468011C>T	uc002yto.2	+	2	1026	c.514C>T	c.(514-516)CTG>TTG	p.L172L	MRPS6_uc002ytp.2_Intron	NM_006933	NP_008864	P53794	SC5A3_HUMAN	solute carrier family 5 (inositol transporters),	172	Helical; (Potential).					integral to plasma membrane	myo-inositol:sodium symporter activity			ovary(2)	2						GACTGCTTTGCTGACTGTCAC	0.473		NaN											0	0	0	0.004878	0	29	84									
COL18A1	80781	broad.mit.edu	37	21	46876059	46876059	+	Silent	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr21:46876059C>G	uc011afs.1	+	1	636	c.615C>G	c.(613-615)CTC>CTG	p.L205L	COL18A1_uc002zhg.2_Intron|COL18A1_uc002zhi.2_Silent_p.L205L	NM_130444	NP_569711	P39060	COIA1_HUMAN	alpha 1 type XVIII collagen isoform 3 precursor	205					cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			central_nervous_system(1)	1				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		GGGCACCACTCACGGGGCCCT	0.687		NaN											0	0	0	0.010504	0	18	52									
IL17RA	23765	broad.mit.edu	37	22	17579721	17579721	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr22:17579721G>A	uc002zly.2	+	4	500	c.367G>A	c.(367-369)GAA>AAA	p.E123K	IL17RA_uc010gqt.2_Missense_Mutation_p.E123K	NM_014339	NP_055154	Q96F46	I17RA_HUMAN	interleukin 17A receptor precursor	123	Extracellular (Potential).				fibroblast activation|positive regulation of interleukin-23 production	integral to plasma membrane	interleukin-17 receptor activity			skin(2)	2		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.241)		GAACACCAATGAACGTTTGTG	0.512		NaN											0	0	0	0.008361	0	26	102									
CLTCL1	8218	broad.mit.edu	37	22	19196576	19196576	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr22:19196576C>G	uc002zpb.2	-	21	3373	c.3298G>C	c.(3298-3300)GAG>CAG	p.E1100Q	CLTCL1_uc011agv.1_Missense_Mutation_p.E1100Q|CLTCL1_uc011agw.1_Missense_Mutation_p.E1100Q|CLTCL1_uc011agt.1_5'Flank|CLTCL1_uc011agu.1_5'Flank|CLTCL1_uc010grm.1_5'UTR|CLTCL1_uc002zpe.2_Missense_Mutation_p.E60Q|CLTCL1_uc002zpd.1_Missense_Mutation_p.E60Q	NM_007098	NP_009029	P53675	CLH2_HUMAN	clathrin, heavy polypeptide-like 1 isoform 1	1100	Proximal segment.|Heavy chain arm.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			ovary(4)|central_nervous_system(1)	5	Colorectal(54;0.0993)					TTGCATCTCTCCGCAAACTCA	0.517		NaN	T	NaN	ALCL								0	0	0	0.00308	0	7	16									
RTN4R	65078	broad.mit.edu	37	22	20230351	20230351	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr22:20230351G>C	uc002zrv.2	-	2	506	c.305C>G	c.(304-306)ACT>AGT	p.T102S	RTN4R_uc002zru.2_5'UTR	NM_023004	NP_075380	Q9BZR6	RTN4R_HUMAN	reticulon 4 receptor precursor	102	LRR 2.				axonogenesis|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	anchored to membrane|cell surface|endoplasmic reticulum|plasma membrane	protein binding|receptor activity				0	Colorectal(54;0.0993)					GGCCAGGCCAGTGAAGGCAGC	0.637		NaN											0	0	0	0.00361	0	48	25									
SNAP29	9342	broad.mit.edu	37	22	21213633	21213633	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr22:21213633G>A	uc011ahw.1	+	1	342	c.235G>A	c.(235-237)GAG>AAG	p.E79K	PI4KA_uc002zsz.3_5'Flank|PI4KA_uc010gsq.1_5'Flank	NM_004782	NP_004773	O95721	SNP29_HUMAN	synaptosomal-associated protein 29	79	Potential.				cellular membrane fusion|exocytosis|protein transport|vesicle targeting	cell junction|cytoplasm|nucleus|synapse|synaptosome	SNAP receptor activity				0	all_cancers(11;2.77e-25)|all_epithelial(7;8.92e-24)|Lung NSC(8;1.49e-15)|all_lung(8;2.54e-14)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000592)|Lung(15;0.0117)			CGCCTCTTCCGAGGTGAGCCT	0.612		NaN											0	0	0	0.003755	0	27	44									
AP1B1	162	broad.mit.edu	37	22	29738343	29738343	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr22:29738343C>T	uc003afj.2	-	12	1651	c.1467G>A	c.(1465-1467)GTG>GTA	p.V489V	AP1B1_uc003afi.2_Silent_p.V489V|AP1B1_uc003afk.2_Silent_p.V489V|AP1B1_uc003afl.2_Silent_p.V489V|AP1B1_uc011ako.1_Silent_p.V42V	NM_001127	NP_001118	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1 beta 1 subunit	489					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			ovary(1)|skin(1)	2						GAAAGAGTTTCACAATGGCTG	0.582		NaN											0	0	0	0.00361	0	61	19									
ASCC2	84164	broad.mit.edu	37	22	30185085	30185085	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr22:30185085C>A	uc003agr.2	-	20	2296	c.2191G>T	c.(2191-2193)GAA>TAA	p.E731*	ASCC2_uc003ags.2_RNA|ASCC2_uc003agt.2_Nonsense_Mutation_p.E731*|ASCC2_uc011akr.1_Nonsense_Mutation_p.E655*	NM_032204	NP_115580	Q9H1I8	ASCC2_HUMAN	activating signal cointegrator 1 complex subunit	731					regulation of transcription, DNA-dependent|transcription, DNA-dependent						0			OV - Ovarian serous cystadenocarcinoma(5;0.000103)|Epithelial(10;0.0169)|all cancers(5;0.0259)			TTGTTGGCTTCCTTCTTCCTG	0.622		NaN											1	0	2.43435e-39	0.00361	2.65603e-39	119	403									
SLC5A4	6527	broad.mit.edu	37	22	32616910	32616910	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr22:32616910C>T	uc003ami.2	-	14	1767	c.1765G>A	c.(1765-1767)GAA>AAA	p.E589K		NM_014227	NP_055042	Q9NY91	SC5A4_HUMAN	solute carrier family 5 (low affinity glucose	589	Cytoplasmic (Potential).				carbohydrate transport|sodium ion transport	integral to membrane	symporter activity				0						ATATTACCTTCTTCAACACCA	0.408		NaN											0	0	0	0.00361	0	47	65									
RASD2	23551	broad.mit.edu	37	22	35947637	35947637	+	Missense_Mutation	SNP	A	A	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr22:35947637A>G	uc003anx.2	+	3	564	c.359A>G	c.(358-360)AAG>AGG	p.K120R	RASD2_uc003any.2_Missense_Mutation_p.K120R	NM_014310	NP_055125	Q96D21	RHES_HUMAN	RASD family, member 2 precursor	120					locomotory behavior|positive regulation of protein kinase B signaling cascade|positive regulation of protein sumoylation|regulation of cAMP-mediated signaling	intracellular|plasma membrane	G-protein beta-subunit binding|GTP binding|GTPase activity			lung(2)|skin(1)	3						CTGGAGGTCAAGTCCTGCCTG	0.597		NaN											0	0	0	0.003755	0	28	98									
MYH9	4627	broad.mit.edu	37	22	36681357	36681357	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr22:36681357C>T	uc003apg.2	-	38	5524	c.5293G>A	c.(5293-5295)GAC>AAC	p.D1765N		NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	1765	Potential.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						AGGTTCAGGTCGGTGTTGATC	0.617		NaN	T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				0	0	0	0.007835	0	36	118									
TXN2	25828	broad.mit.edu	37	22	36876824	36876824	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr22:36876824G>C	uc003apk.1	-	2	138	c.61C>G	c.(61-63)CAG>GAG	p.Q21E	TXN2_uc003apl.1_RNA	NM_012473	NP_036605	Q99757	THIOM_HUMAN	thioredoxin 2 precursor	21					cell redox homeostasis|electron transport chain|glycerol ether metabolic process|transport	mitochondrion|nucleolus	electron carrier activity				0						CACTGACCCTGAGAGGGCTTC	0.577		NaN											0	0	0	0.00333	0	23	78									
FOXRED2	80020	broad.mit.edu	37	22	36900716	36900716	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr22:36900716C>T	uc003apn.3	-	2	733	c.625G>A	c.(625-627)GAG>AAG	p.E209K	FOXRED2_uc003apo.3_Missense_Mutation_p.E209K|FOXRED2_uc003app.3_Missense_Mutation_p.E209K	NM_024955	NP_079231	Q8IWF2	FXRD2_HUMAN	FAD-dependent oxidoreductase domain containing 2	209					ER-associated protein catabolic process	endoplasmic reticulum lumen	flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			lung(1)|kidney(1)	2						ACAAAGTCCTCAGGGTCCACG	0.527		NaN											0	0	0	0.00361	0	63	44									
RPL3	6122	broad.mit.edu	37	22	39712783	39712783	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr22:39712783C>G	uc003axi.2	-	4	497	c.429G>C	c.(427-429)AAG>AAC	p.K143N	RPL3_uc003axh.2_Intron|RPL3_uc003axj.2_5'UTR|RPL3_uc010gxx.2_Missense_Mutation_p.K91N|RPL3_uc003axg.2_Missense_Mutation_p.K91N|RPL3_uc003axk.1_5'UTR	NM_000967	NP_000958	P39023	RL3_HUMAN	ribosomal protein L3 isoform a	143					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome			breast(1)|kidney(1)	2	Melanoma(58;0.04)					CCAGCTGCTTCTTGCCATCCT	0.547		NaN									OREG0026575	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.007291	0	29	106									
FAM83F	113828	broad.mit.edu	37	22	40417887	40417887	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr22:40417887G>A	uc003ayk.1	+	4	1467	c.1373G>A	c.(1372-1374)AGC>AAC	p.S458N		NM_138435	NP_612444	Q8NEG4	FA83F_HUMAN	hypothetical protein LOC113828	458										breast(1)	1						GGCATGGCCAGCTCTGTCTCC	0.657		NaN											0	0	0	0.010504	0	14	80									
EP300	2033	broad.mit.edu	37	22	41537064	41537064	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr22:41537064C>G	uc003azl.3	+	10	2286	c.1891C>G	c.(1891-1893)CAC>GAC	p.H631D		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	631	KIX.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						GGAATACTACCACCTTCTAGC	0.373		NaN	T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				0	0	0	0.006122	0	16	15									
TCF20	6942	broad.mit.edu	37	22	42607575	42607575	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr22:42607575G>C	uc003bcj.1	-	1	3871	c.3737C>G	c.(3736-3738)TCT>TGT	p.S1246C	TCF20_uc003bck.1_Missense_Mutation_p.S1246C|TCF20_uc003bnt.2_Missense_Mutation_p.S1246C	NM_005650	NP_005641	Q9UGU0	TCF20_HUMAN	transcription factor 20 isoform 1	1246					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(4)|skin(1)	5						GTTTTGAGAAGAATGATCCTC	0.483		NaN											0	0	0	0.00333	0	21	60									
CYB5R3	1727	broad.mit.edu	37	22	43032768	43032768	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr22:43032768G>A	uc003bcz.2	-	2	190	c.106C>T	c.(106-108)CTC>TTC	p.L36F	CYB5R3_uc010gzc.1_5'UTR|CYB5R3_uc003bcw.2_Missense_Mutation_p.L26F|CYB5R3_uc011aps.1_Missense_Mutation_p.L69F|CYB5R3_uc003bcy.2_Missense_Mutation_p.L13F|CYB5R3_uc003bcx.2_Missense_Mutation_p.L13F	NM_000398	NP_000389	P00387	NB5R3_HUMAN	cytochrome b5 reductase 3 isoform m	36					blood circulation|cholesterol biosynthetic process|water-soluble vitamin metabolic process	endoplasmic reticulum membrane|hemoglobin complex|mitochondrial outer membrane	cytochrome-b5 reductase activity			skin(1)	1					NADH(DB00157)	GGGCTCTCGAGGGTGATGGCT	0.627		NaN											0	0	0	0.003271	0	33	28									
TMEM40	55287	broad.mit.edu	37	3	12783978	12783978	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:12783978C>G	uc003bxg.1	-	5	457	c.330G>C	c.(328-330)TTG>TTC	p.L110F	TMEM40_uc003bxh.1_Missense_Mutation_p.L80F|TMEM40_uc003bxi.1_Missense_Mutation_p.L34F|TMEM40_uc011auv.1_Missense_Mutation_p.L126F	NM_018306	NP_060776	Q8WWA1	TMM40_HUMAN	transmembrane protein 40	110						integral to membrane					0						GCTCATCCTTCAAAACGTCAG	0.517		NaN											0	0	0	0.00361	0	74	98									
GRIP2	80852	broad.mit.edu	37	3	14583429	14583429	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:14583429G>T	uc011avi.1	-	1	160	c.160C>A	c.(160-162)CAT>AAT	p.H54N	GRIP2_uc011avh.1_5'Flank|GRIP2_uc003byv.1_5'Flank	NM_001080423	NP_001073892	Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2	Error:Variant_position_missing_in_Q9C0E4_after_alignment					synaptic transmission	cytosol|plasma membrane	protein binding			pancreas(1)	1						GGCTCGCCATGAAGACCCTGG	0.572		NaN											1	0	1.33987e-11	0.008291	1.40155e-11	8	12									
MRPS25	64432	broad.mit.edu	37	3	15094937	15094937	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:15094937C>G	uc003bzl.2	-	3	394	c.279G>C	c.(277-279)AAG>AAC	p.K93N	MRPS25_uc011avl.1_Intron|MRPS25_uc011avm.1_Missense_Mutation_p.K93N	NM_022497	NP_071942	P82663	RT25_HUMAN	mitochondrial ribosomal protein S25	93					translation	mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome				0						CCTTATTGCTCTTGGTCTCCA	0.488		NaN											0	0	0	0.00278	0	18	58									
MRPS25	64432	broad.mit.edu	37	3	15094945	15094945	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:15094945C>G	uc003bzl.2	-	3	386	c.271G>C	c.(271-273)GAG>CAG	p.E91Q	MRPS25_uc011avl.1_Intron|MRPS25_uc011avm.1_Missense_Mutation_p.E91Q	NM_022497	NP_071942	P82663	RT25_HUMAN	mitochondrial ribosomal protein S25	91					translation	mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome				0						CTCTTGGTCTCCACATCCACC	0.473		NaN											0	0	0	0.00278	0	17	58									
EFHB	151651	broad.mit.edu	37	3	19975088	19975088	+	Silent	SNP	C	C	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:19975088C>A	uc003cbl.3	-	1	619	c.423G>T	c.(421-423)GGG>GGT	p.G141G	EFHB_uc003cbm.2_Intron	NM_144715	NP_653316	Q8N7U6	EFHB_HUMAN	EF hand domain family, member B	141					signal transduction	proteinaceous extracellular matrix	calcium ion binding				0						CTCTCCTGCTCCCTGCAGCCT	0.493		NaN											1	0	4.26978e-12	0.00333	4.48055e-12	21	82									
SCN5A	6331	broad.mit.edu	37	3	38622656	38622656	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:38622656C>G	uc003cio.2	-	17	3188	c.2994G>C	c.(2992-2994)CAG>CAC	p.Q998H	SCN5A_uc003cin.2_Missense_Mutation_p.Q998H|SCN5A_uc003cil.3_Missense_Mutation_p.Q998H|SCN5A_uc010hhi.2_Missense_Mutation_p.Q998H|SCN5A_uc010hhk.2_Missense_Mutation_p.Q998H|SCN5A_uc011ayr.1_Missense_Mutation_p.Q998H|SCN5A_uc010hhj.1_Missense_Mutation_p.Q609H	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	998					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	GCAGCTGGCCCTGGGCGGCAA	0.672		NaN											0	0	0	0.003163	0	14	15									
HHATL	57467	broad.mit.edu	37	3	42734575	42734575	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:42734575G>A	uc003clw.2	-	12	1531	c.1384C>T	c.(1384-1386)CTC>TTC	p.L462F	HHATL_uc003clx.2_Missense_Mutation_p.L462F	NM_020707	NP_065758	Q9HCP6	HHATL_HUMAN	hedgehog acyltransferase-like	462	Helical; (Potential).				negative regulation of N-terminal protein palmitoylation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm				ovary(3)	3				KIRC - Kidney renal clear cell carcinoma(284;0.215)		TCACCTGTGAGTAGCAGGCGC	0.567		NaN											0	0	0	0.009096	0	4	264									
BSN	8927	broad.mit.edu	37	3	49698105	49698105	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:49698105G>A	uc003cxe.3	+	6	8941	c.8827G>A	c.(8827-8829)GAG>AAG	p.E2943K		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	2943	Potential.				synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CCTGCTCCGGGAGCTGGACCG	0.657		NaN											0	0	0	0.008291	0	7	22									
C3orf54	389119	broad.mit.edu	37	3	49842359	49842359	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:49842359C>A	uc003cxq.1	+	2	936	c.803C>A	c.(802-804)GCA>GAA	p.A268E		NM_203370	NP_976248	Q96EL1	CC054_HUMAN	hypothetical protein LOC389119	266											0				BRCA - Breast invasive adenocarcinoma(193;3.55e-06)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		TCACGCTTTGCAGCTCTCATG	0.597		NaN											1	0	1.23719e-20	0.00361	1.33658e-20	70	216									
SEMA3B	7869	broad.mit.edu	37	3	50314055	50314055	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:50314055C>T	uc003cyu.2	+	19	2410	c.2168C>T	c.(2167-2169)TCG>TTG	p.S723L	SEMA3B_uc003cyt.2_Missense_Mutation_p.S722L|SEMA3B_uc003cyv.2_Missense_Mutation_p.S610L|SEMA3B_uc003cyw.2_Missense_Mutation_p.S446L|SEMA3B_uc010hli.2_Missense_Mutation_p.S615L|SEMA3B_uc003cyx.2_Missense_Mutation_p.S609L|SEMA3B_uc003cyy.2_Missense_Mutation_p.S380L|SEMA3B_uc011bdo.1_Missense_Mutation_p.S380L|C3orf45_uc003cyz.2_5'Flank	NM_004636	NP_004627	Q13214	SEM3B_HUMAN	semaphorin 3B isoform 1 precursor	723					axon guidance|cell-cell signaling	endoplasmic reticulum|extracellular region|membrane	receptor activity			lung(2)|central_nervous_system(2)|kidney(1)|skin(1)	6				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		CCCCTGGAGTCGCGGAGAAAG	0.721		NaN											0	0	0	0.00499	0	14	8									
ACY1	95	broad.mit.edu	37	3	52019910	52019910	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:52019910G>C	uc003dcp.2	+	5	368	c.307G>C	c.(307-309)GAG>CAG	p.E103Q	ABHD14B_uc003dcn.2_5'Flank|ACY1_uc011bea.1_Missense_Mutation_p.E193Q|ACY1_uc011beb.1_Missense_Mutation_p.E103Q|ACY1_uc003dcq.2_Missense_Mutation_p.E103Q	NM_000666	NP_000657	Q03154	ACY1_HUMAN	aminoacylase 1	103					cellular amino acid metabolic process|proteolysis	cytosol	aminoacylase activity|metal ion binding|metallopeptidase activity			breast(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	L-Aspartic Acid(DB00128)	CAAGGATTCTGAGGGCTACAT	0.552		NaN											0	0	0	0.010729	0	9	19									
ACTR8	93973	broad.mit.edu	37	3	53905383	53905383	+	Silent	SNP	C	C	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:53905383C>A	uc003dhd.2	-	11	1502	c.1443G>T	c.(1441-1443)CTG>CTT	p.L481L	ACTR8_uc003dhb.2_Silent_p.L186L|ACTR8_uc003dhc.2_Silent_p.L370L	NM_022899	NP_075050	Q9H981	ARP8_HUMAN	actin-related protein 8	481					cell division|DNA recombination|DNA repair|mitosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex	protein binding			ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000143)|KIRC - Kidney renal clear cell carcinoma(284;0.00544)|Kidney(284;0.00607)|OV - Ovarian serous cystadenocarcinoma(275;0.111)		TGCCGGCCATCAGGCCATCTC	0.547		NaN											1	0	2.65435e-51	0.00361	2.92023e-51	87	78									
FAM3D	131177	broad.mit.edu	37	3	58631354	58631354	+	Splice_Site	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:58631354C>G	uc003dkq.2	-	5	443	c.146_splice	c.e5-1	p.Q49_splice		NM_138805	NP_620160	Q96BQ1	FAM3D_HUMAN	family with sequence similarity 3, member D						negative regulation of insulin secretion	extracellular region	cytokine activity				0				BRCA - Breast invasive adenocarcinoma(55;0.000225)|Kidney(10;0.000667)|KIRC - Kidney renal clear cell carcinoma(10;0.000802)|OV - Ovarian serous cystadenocarcinoma(275;0.169)		TTTTTAACCTCTGGGGAGGAA	0.587		NaN											0	0	0	0.00361	0	57	34									
SHQ1	55164	broad.mit.edu	37	3	72890342	72890342	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:72890342C>G	uc003dpf.2	-	4	447	c.340G>C	c.(340-342)GAG>CAG	p.E114Q	SHQ1_uc010hod.2_Missense_Mutation_p.E25Q	NM_018130	NP_060600	Q6PI26	SHQ1_HUMAN	SHQ1 homolog	114					ribonucleoprotein complex assembly	cytosol|nucleoplasm	protein binding			ovary(2)|large_intestine(1)	3		Prostate(10;0.00482)|Lung NSC(201;0.0339)|Myeloproliferative disorder(1037;0.204)		BRCA - Breast invasive adenocarcinoma(55;9.68e-05)|Epithelial(33;0.000563)|LUSC - Lung squamous cell carcinoma(21;0.00229)|Lung(16;0.00688)|KIRC - Kidney renal clear cell carcinoma(39;0.018)|Kidney(39;0.0213)		TCAGGAATCTCAGAAGCACCT	0.338		NaN											0	0	0	0.001368	0	13	21									
CNTN3	5067	broad.mit.edu	37	3	74344388	74344388	+	Splice_Site	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:74344388C>G	uc003dpm.1	-	18	2482	c.2402_splice	c.e18-1	p.E801_splice		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor						cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		ACTGTAGGCTCTGTTCGGAAA	0.353		NaN											0	0	0	0.006999	0	37	23									
ST3GAL6	10402	broad.mit.edu	37	3	98510824	98510824	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:98510824C>T	uc003dsz.2	+	9	1132	c.896C>T	c.(895-897)TCT>TTT	p.S299F	ST3GAL6_uc003dsy.2_Missense_Mutation_p.S213F|ST3GAL6_uc003dta.2_Missense_Mutation_p.S181F|ST3GAL6_uc003dtb.2_Missense_Mutation_p.S155F|ST3GAL6_uc003dtc.2_Missense_Mutation_p.S299F|ST3GAL6_uc010hpd.2_Missense_Mutation_p.S352F	NM_006100	NP_006091	Q9Y274	SIA10_HUMAN	alpha2,3-sialyltransferase VI	299	Lumenal (Potential).				amino sugar metabolic process|glycolipid metabolic process|protein glycosylation|protein lipoylation	integral to Golgi membrane	sialyltransferase activity			ovary(1)	1						GCCACCATGTCTTTGATGAAT	0.373		NaN											0	0	0	0.009535	0	23	53									
IMPG2	50939	broad.mit.edu	37	3	101038512	101038512	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:101038512G>A	uc003duq.1	-	2	453	c.250C>T	c.(250-252)CTG>TTG	p.L84L	IMPG2_uc011bhe.1_5'UTR	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	84	Extracellular (Potential).				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						TTAGGAAACAGAATAGATCTC	0.428		NaN											0	0	0	0.00632	0	27	85									
CBLB	868	broad.mit.edu	37	3	105421029	105421029	+	Nonsense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:105421029G>C	uc003dwc.2	-	12	2190	c.1868C>G	c.(1867-1869)TCA>TGA	p.S623*	CBLB_uc011bhi.1_Nonsense_Mutation_p.S645*|CBLB_uc003dwd.1_Nonsense_Mutation_p.S623*|CBLB_uc003dwe.1_Nonsense_Mutation_p.S623*	NM_170662	NP_733762	Q13191	CBLB_HUMAN	Cas-Br-M (murine) ecotropic retroviral	623	Pro-rich.				cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			lung(4)|ovary(3)|breast(1)|skin(1)	9						ATTGACATTTGAACTCGCTGT	0.502		NaN	Mis S		AML								0	0	0	0.010504	0	21	51									
CCDC80	151887	broad.mit.edu	37	3	112358139	112358139	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:112358139C>T	uc003dzf.2	-	2	832	c.614G>A	c.(613-615)AGC>AAC	p.S205N	CCDC80_uc011bhv.1_Missense_Mutation_p.S205N|CCDC80_uc003dzg.2_Missense_Mutation_p.S205N|CCDC80_uc003dzh.1_Missense_Mutation_p.S205N	NM_199512	NP_955806	Q76M96	CCD80_HUMAN	steroid-sensitive protein 1 precursor	205										ovary(2)	2						CTGGCCCTCGCTGGTGATCCT	0.577		NaN											0	0	0	0.00361	0	59	61									
IQCB1	9657	broad.mit.edu	37	3	121509013	121509013	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:121509013C>A	uc010hre.1	-	11	1251	c.1036G>T	c.(1036-1038)GAG>TAG	p.E346*	IQCB1_uc003eek.2_Nonsense_Mutation_p.E213*|IQCB1_uc010hrf.1_RNA	NM_001023570	NP_001018864	Q15051	IQCB1_HUMAN	IQ motif containing B1 isoform a	346	Potential.				cilium assembly|maintenance of organ identity|photoreceptor cell maintenance	centrosome|photoreceptor connecting cilium	calmodulin binding				0				GBM - Glioblastoma multiforme(114;0.0983)		TTGAGGTCCTCTTCTTCCTTC	0.373		NaN											1	0	6.02501e-08	0.00623	6.21359e-08	34	104									
SLC15A2	6565	broad.mit.edu	37	3	121642098	121642098	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:121642098G>A	uc003eep.2	+	11	1140	c.987G>A	c.(985-987)AGG>AGA	p.R329R	SLC15A2_uc011bjn.1_Silent_p.R298R	NM_021082	NP_066568	Q16348	S15A2_HUMAN	peptide transporter 2 isoform a	329					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	AAGCCATCAGGATGAATAGGA	0.403		NaN											0	0	0	0.008871	0	18	63									
ZNF148	7707	broad.mit.edu	37	3	124952313	124952313	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:124952313C>A	uc003ehx.3	-	9	1743	c.1257G>T	c.(1255-1257)GAG>GAT	p.E419D	SLC12A8_uc003ehw.3_Intron|ZNF148_uc003ehz.3_Missense_Mutation_p.E419D|ZNF148_uc010hsa.2_Missense_Mutation_p.E419D|ZNF148_uc003eia.3_Missense_Mutation_p.E419D|ZNF148_uc003ehy.2_Intron	NM_021964	NP_068799	Q9UQR1	ZN148_HUMAN	zinc finger protein 148	419					cellular defense response|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4						AAACTTTGCTCTCTTCATATG	0.373		NaN											1	0	4.36969e-10	0.001855	4.53484e-10	13	49									
COL6A6	131873	broad.mit.edu	37	3	130292929	130292929	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:130292929G>A	uc010htl.2	+	7	3138	c.3107G>A	c.(3106-3108)AGA>AAA	p.R1036K		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	1036	Nonhelical region.|VWFA 6.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						AGCCTCAACAGAGTGCGAATA	0.418		NaN											0	0	0	0.004672	0	3	12									
SLCO2A1	6578	broad.mit.edu	37	3	133670119	133670119	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:133670119G>A	uc003eqa.3	-	6	1068	c.794C>T	c.(793-795)TCA>TTA	p.S265L	SLCO2A1_uc003eqb.3_Missense_Mutation_p.S189L|SLCO2A1_uc011blv.1_Intron|SLCO2A1_uc010htw.1_Missense_Mutation_p.S97L	NM_005630	NP_005621	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family,	265	Helical; Name=6; (Potential).				sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			central_nervous_system(1)	1						CAATAAAGCTGAAGAAATGAG	0.493		NaN											0	0	0	0.012213	0	33	33									
PPP2R3A	5523	broad.mit.edu	37	3	135820922	135820922	+	Missense_Mutation	SNP	T	T	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:135820922T>C	uc003eqv.1	+	11	3566	c.3001T>C	c.(3001-3003)TAT>CAT	p.Y1001H	PPP2R3A_uc011blz.1_Missense_Mutation_p.Y265H|PPP2R3A_uc003eqw.1_Missense_Mutation_p.Y380H	NM_002718	NP_002709	Q06190	P2R3A_HUMAN	protein phosphatase 2, regulatory subunit B'',	1001	EF-hand 2.				protein dephosphorylation	protein phosphatase type 2A complex	calcium ion binding|protein binding|protein phosphatase type 2A regulator activity			ovary(3)|pancreas(1)|lung(1)|breast(1)|skin(1)	7						GGAGTACTTCTATGAGGAGCA	0.468		NaN											0	0	0	0.00333	0	22	29									
PAQR9	344838	broad.mit.edu	37	3	142682017	142682017	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:142682017G>A	uc003evg.2	-	1	162	c.162C>T	c.(160-162)TTC>TTT	p.F54F	PAQR9_uc003evf.1_5'Flank	NM_198504	NP_940906	Q6ZVX9	PAQR9_HUMAN	progestin and adipoQ receptor family member IX	54	Cytoplasmic (Potential).					integral to membrane	receptor activity				0						AGCACTCCACGAAGTCGTCGG	0.687		NaN											0	0	0	0.00308	0	7	5									
TM4SF4	7104	broad.mit.edu	37	3	149220466	149220466	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:149220466G>C	uc003exd.1	+	5	826	c.595G>C	c.(595-597)GAT>CAT	p.D199H		NM_004617	NP_004608	P48230	T4S4_HUMAN	transmembrane 4 superfamily member 4	199	Cytoplasmic (Potential).					integral to membrane					0			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			CTTCTAGGGAGATGGACCCGT	0.403		NaN											0	0	0	0.00361	0	63	42									
SI	6476	broad.mit.edu	37	3	164733762	164733762	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:164733762C>T	uc003fei.2	-	32	3928	c.3866G>A	c.(3865-3867)GGA>GAA	p.G1289E		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1289	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GTATCTCATTCCTTCTCCTCT	0.403		NaN								HNSCC(35;0.089)			0	0	0	0.010504	0	17	69									
MECOM	2122	broad.mit.edu	37	3	168834306	168834306	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:168834306C>A	uc003ffi.3	-	7	1059	c.790G>T	c.(790-792)GAT>TAT	p.D264Y	MECOM_uc010hwk.1_Missense_Mutation_p.D287Y|MECOM_uc003ffj.3_Missense_Mutation_p.D329Y|MECOM_uc011bpi.1_Missense_Mutation_p.D265Y|MECOM_uc003ffn.3_Missense_Mutation_p.D264Y|MECOM_uc003ffk.2_Missense_Mutation_p.D264Y|MECOM_uc003ffl.2_Missense_Mutation_p.D424Y|MECOM_uc011bpj.1_Missense_Mutation_p.D452Y|MECOM_uc011bpk.1_Missense_Mutation_p.D254Y|MECOM_uc010hwn.2_Missense_Mutation_p.D452Y	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	264					apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						GACGTTTTATCCATAGCTGGG	0.478		NaN											1	0	5.8336e-16	0.003271	6.19057e-16	35	31									
LRRIQ4	344657	broad.mit.edu	37	3	169539844	169539844	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:169539844C>T	uc003fgb.2	+	1	135	c.135C>T	c.(133-135)TTC>TTT	p.F45F		NM_001080460	NP_001073929	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	45	LRR 1.										0						TGGAGATCTTCACATTCACAG	0.398		NaN											0	0	0	0.012319	0	15	60									
TBL1XR1	79718	broad.mit.edu	37	3	176755921	176755921	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:176755921G>C	uc003fiw.3	-	12	1347	c.1087C>G	c.(1087-1089)CTC>GTC	p.L363V	TBL1XR1_uc003fix.3_Missense_Mutation_p.L363V|TBL1XR1_uc011bpz.1_Missense_Mutation_p.L35V	NM_024665	NP_078941	Q9BZK7	TBL1R_HUMAN	transducin (beta)-like 1 X-linked receptor 1	363	WD 5.				canonical Wnt receptor signaling pathway|cellular lipid metabolic process|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein N-terminus binding|transcription corepressor activity|transcription regulatory region DNA binding			ovary(1)	1	all_cancers(143;1.44e-17)|Ovarian(172;0.00163)|Breast(254;0.214)	Acute lymphoblastic leukemia(1;0.00599)|all_hematologic(1;0.0632)|Prostate(884;0.215)	OV - Ovarian serous cystadenocarcinoma(80;9.83e-31)			GAGGCCAAGAGATTGCCAGTT	0.383		NaN											0	0	0	0.008361	0	21	23									
USP13	8975	broad.mit.edu	37	3	179371085	179371085	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:179371085C>T	uc003fkh.2	+	1	153	c.72C>T	c.(70-72)ATC>ATT	p.I24I	USP13_uc003fkf.2_Silent_p.I24I	NM_003940	NP_003931	Q92995	UBP13_HUMAN	ubiquitin thiolesterase 13	24					ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(1)	1	all_cancers(143;7.79e-15)|Ovarian(172;0.0338)|Breast(254;0.148)		OV - Ovarian serous cystadenocarcinoma(80;1e-25)|GBM - Glioblastoma multiforme(14;0.0169)			CAGGAGACATCGGCGAGCTGC	0.692		NaN											0	0	0	0.000602	0	4	3									
CHRD	8646	broad.mit.edu	37	3	184099750	184099750	+	Nonsense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:184099750C>G	uc003fov.2	+	6	887	c.641C>G	c.(640-642)TCA>TGA	p.S214*	CHRD_uc003fow.2_5'UTR|CHRD_uc003fox.2_Nonsense_Mutation_p.S214*|CHRD_uc003foy.2_5'UTR|CHRD_uc010hyc.2_5'UTR|CHRD_uc011brr.1_5'Flank	NM_003741	NP_003732	Q9H2X0	CHRD_HUMAN	chordin precursor	214	CHRD 1.				BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			skin(2)|ovary(1)	3	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			ATCCGCTTCTCAGACTCCAAT	0.527		NaN											0	0	0	0.004656	0	22	50									
ACAP2	23527	broad.mit.edu	37	3	195063325	195063325	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:195063325C>G	uc003fun.3	-	6	644	c.403G>C	c.(403-405)GAA>CAA	p.E135Q	ACAP2_uc003fuo.2_Missense_Mutation_p.E135Q	NM_012287	NP_036419	Q15057	ACAP2_HUMAN	centaurin, beta 2	135	BAR.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)	2						AACGCATTTTCTTTTTCTTCA	0.328		NaN											0	0	0	0.001855	0	14	5									
TFRC	7037	broad.mit.edu	37	3	195780393	195780393	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:195780393G>A	uc003fvz.3	-	18	2219	c.1936C>T	c.(1936-1938)CGT>TGT	p.R646C	TFRC_uc003fwa.3_Missense_Mutation_p.R646C|TFRC_uc010hzy.2_Missense_Mutation_p.R565C|TFRC_uc011btr.1_Missense_Mutation_p.R364C	NM_003234	NP_003225	P02786	TFR1_HUMAN	transferrin receptor	646	Cell attachment site; required for binding to transferrin.|Extracellular (Potential).|Ligand-binding.			R->A,H: No binding to transferrin.|R->K: 5% binding to transferrin.	cellular iron ion homeostasis|endocytosis|interspecies interaction between organisms|proteolysis|transferrin transport|transmembrane transport	coated pit|endosome|integral to plasma membrane|melanosome	peptidase activity|transferrin receptor activity			ovary(3)	3	all_cancers(143;1.94e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.36e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.17e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00233)		AAGTCTCCACGAGCAGAATAC	0.403		NaN	T	BCL6	NHL								0	0	0	0.00361	0	68	59									
GAK	2580	broad.mit.edu	37	4	844837	844837	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr4:844837C>G	uc003gbm.3	-	26	3743	c.3544G>C	c.(3544-3546)GAT>CAT	p.D1182H	GAK_uc003gbn.3_Missense_Mutation_p.D1103H|GAK_uc003gbk.3_Intron|GAK_uc010ibi.2_Missense_Mutation_p.D407H|GAK_uc010ibj.2_RNA|GAK_uc003gbl.3_Missense_Mutation_p.D1035H	NM_005255	NP_005246	O14976	GAK_HUMAN	cyclin G associated kinase	1182					cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			lung(2)|central_nervous_system(1)|skin(1)	4				Colorectal(103;0.219)		GACAACAGATCTTCAAAGTCG	0.363		NaN											0	0	0	0.012319	0	19	49									
POLN	353497	broad.mit.edu	37	4	2172884	2172884	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr4:2172884C>G	uc003ger.2	-	10	1399	c.1399G>C	c.(1399-1401)GAA>CAA	p.E467Q	POLN_uc010ich.1_Missense_Mutation_p.E58Q|POLN_uc011bvi.1_Missense_Mutation_p.E467Q	NM_181808	NP_861524	Q7Z5Q5	DPOLN_HUMAN	DNA-directed DNA polymerase nu	467					DNA repair|DNA replication	nucleus	DNA binding|DNA-directed DNA polymerase activity			kidney(2)|ovary(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(23;0.0955)			AAATGAGCTTCTTGCTCCAAT	0.323		NaN						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.00874	0	34	18									
OTOP1	133060	broad.mit.edu	37	4	4199382	4199382	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr4:4199382G>A	uc003ghp.1	-	5	1209	c.1179C>T	c.(1177-1179)CTC>CTT	p.L393L		NM_177998	NP_819056	Q7RTM1	OTOP1_HUMAN	otopetrin 1	393	Helical; (Potential).				biomineral tissue development	extracellular space|integral to membrane				ovary(2)|central_nervous_system(1)	3				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TGCCCACCAAGAGGTCCGAGT	0.597		NaN											0	0	0	0.00361	0	55	62									
TBC1D1	23216	broad.mit.edu	37	4	38138896	38138896	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr4:38138896G>A	uc003gtb.2	+	20	3790	c.3447G>A	c.(3445-3447)CGG>CGA	p.R1149R	TBC1D1_uc011byd.1_Silent_p.R1140R|TBC1D1_uc010ifd.2_Silent_p.R936R|TBC1D1_uc003gtd.2_Silent_p.R161R	NM_015173	NP_055988	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family,	1149						nucleus	Rab GTPase activator activity			ovary(1)	1						TGCGGCGGCGGAGCGCAGAGC	0.647		NaN											0	0	0	0.004007	0	16	193									
N4BP2	55728	broad.mit.edu	37	4	40104488	40104488	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr4:40104488G>A	uc003guy.3	+	4	1361	c.1023G>A	c.(1021-1023)GTG>GTA	p.V341V	N4BP2_uc010ifq.2_Silent_p.V261V|N4BP2_uc010ifr.2_Silent_p.V261V	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	341	Pro-rich.					cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						GGAAGGATGTGAGTTACTGCC	0.502		NaN											0	0	0	0.00333	0	21	37									
LPHN3	23284	broad.mit.edu	37	4	62849139	62849139	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr4:62849139C>T	uc010ihh.2	+	16	3023	c.2850C>T	c.(2848-2850)TTC>TTT	p.F950F	LPHN3_uc003hcq.3_Silent_p.F950F|LPHN3_uc003hct.2_Silent_p.F343F	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	937	Helical; Name=3; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						TACATTTCTTCTTCTTGGCTG	0.438		NaN											0	0	0	0.001855	0	10	18									
FRAS1	80144	broad.mit.edu	37	4	79437102	79437102	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr4:79437102G>A	uc003hlb.2	+	66	10764	c.10324G>A	c.(10324-10326)GAT>AAT	p.D3442N		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3437	Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						GTGGACCTTTGATGCTTATTA	0.557		NaN											0	0	0	0.008291	0	11	27									
WDFY3	23001	broad.mit.edu	37	4	85741262	85741262	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr4:85741262G>A	uc003hpd.2	-	12	2077	c.1669C>T	c.(1669-1671)CTT>TTT	p.L557F	WDFY3_uc003hpf.2_Missense_Mutation_p.L557F	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	557						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		GATCCTTGAAGAAGCACTGTC	0.378		NaN											0	0	0	0.011902	0	35	145									
MMRN1	22915	broad.mit.edu	37	4	90857267	90857267	+	Silent	SNP	T	T	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr4:90857267T>C	uc003hst.2	+	6	2507	c.2436T>C	c.(2434-2436)GAT>GAC	p.D812D	MMRN1_uc010iku.2_Intron|MMRN1_uc011cds.1_Silent_p.D554D	NM_007351	NP_031377	Q13201	MMRN1_HUMAN	multimerin 1	812					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				ovary(4)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		TTCCCAGAGATGAGAAACTAA	0.383		NaN											0	0	0	0.010729	0	9	30									
RAP1GDS1	5910	broad.mit.edu	37	4	99325699	99325699	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr4:99325699G>C	uc003htx.3	+	7	899	c.709G>C	c.(709-711)GAA>CAA	p.E237Q	RAP1GDS1_uc003htw.3_Missense_Mutation_p.E238Q|RAP1GDS1_uc003htv.3_Missense_Mutation_p.E238Q|RAP1GDS1_uc003htz.3_Missense_Mutation_p.E188Q|RAP1GDS1_uc003hty.3_Missense_Mutation_p.E189Q|RAP1GDS1_uc003hua.3_Missense_Mutation_p.E146Q	NM_001100427	NP_001093897	P52306	GDS1_HUMAN	RAP1, GTP-GDP dissociation stimulator 1 isoform	237							binding|GTPase activator activity			ovary(1)|lung(1)|breast(1)	3				OV - Ovarian serous cystadenocarcinoma(123;2.9e-07)|LUSC - Lung squamous cell carcinoma(1;0.0253)|Lung(1;0.0576)		GAAACAAATAGAACATGATAA	0.318		NaN	T	NUP98	T-ALL								0	0	0	0.004482	0	9	25									
ANK2	287	broad.mit.edu	37	4	114278820	114278820	+	Missense_Mutation	SNP	G	G	A	rs149963885	byFrequency	TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr4:114278820G>A	uc003ibe.3	+	38	9146	c.9046G>A	c.(9046-9048)GAG>AAG	p.E3016K	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Missense_Mutation_p.E318K|ANK2_uc011cgb.1_Missense_Mutation_p.E3031K	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	2983					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TTCATCTTTCGAGCCTACTAT	0.398		NaN											0	0	0	0.00361	0	42	76									
SYNPO2	171024	broad.mit.edu	37	4	119951529	119951529	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr4:119951529G>A	uc003icm.3	+	4	1795	c.1599G>A	c.(1597-1599)ACG>ACA	p.T533T	SYNPO2_uc010ina.2_Silent_p.T533T|SYNPO2_uc010inb.2_Silent_p.T533T|SYNPO2_uc011cgh.1_Intron|SYNPO2_uc010inc.2_Silent_p.T461T	NM_001128933	NP_001122405	Q9UMS6	SYNP2_HUMAN	synaptopodin 2 isoform b	533						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			ovary(2)	2						TGAGAACCACGACTTCTTACC	0.507		NaN											0	0	0	0.003954	0	23	20									
OTUD4	54726	broad.mit.edu	37	4	146059006	146059006	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr4:146059006G>A	uc003ika.3	-	21	2864	c.2726C>T	c.(2725-2727)ACT>ATT	p.T909I	OTUD4_uc003ijz.3_Missense_Mutation_p.T908I	NM_001102653	NP_001096123	Q01804	OTUD4_HUMAN	OTU domain containing 4 protein isoform 3	973							protein binding			ovary(2)|breast(1)	3	all_hematologic(180;0.151)					AACAGGCACAGTTTCTCTCTC	0.463		NaN											0	0	0	0.009096	0	4	133									
MORF4	10934	broad.mit.edu	37	4	174537213	174537213	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr4:174537213C>G	uc011cke.1	-	1	582	c.582G>C	c.(580-582)AAG>AAC	p.K194N		NM_006792	NP_006783			mortality factor 4												0		Prostate(90;0.00201)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_neural(102;0.0765)|all_hematologic(60;0.107)		all cancers(43;1.88e-18)|Epithelial(43;1.19e-16)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-09)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		AAGCAAGGCTCTTCTCATTCA	0.438		NaN											0	0	0	0.007291	0	25	46									
ADAMTS16	170690	broad.mit.edu	37	5	5239991	5239991	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr5:5239991G>A	uc003jdl.2	+	16	2614	c.2476G>A	c.(2476-2478)GAG>AAG	p.E826K	ADAMTS16_uc003jdk.1_Missense_Mutation_p.E826K	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	826	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						TAATGAGCCCGAGAACTTAAT	0.517		NaN											0	0	0	0.009535	0	27	118									
KIAA0947	23379	broad.mit.edu	37	5	5460802	5460802	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr5:5460802C>T	uc003jdm.3	+	13	1577	c.1355C>T	c.(1354-1356)TCT>TTT	p.S452F		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	452										ovary(1)|central_nervous_system(1)	2						CTGAGAGAATCTTCTGCCACA	0.408		NaN											0	0	0	0.006214	0	7	27									
RICTOR	253260	broad.mit.edu	37	5	38947495	38947495	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr5:38947495C>T	uc003jlp.2	-	32	4209	c.4185G>A	c.(4183-4185)TTG>TTA	p.L1395L	RICTOR_uc003jlo.2_Silent_p.L1419L|RICTOR_uc010ivf.2_Silent_p.L1110L	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	1395					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding	p.L1395L(1)		ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)					TAATAGGACTCAATAAATCTT	0.373		NaN											0	0	0	0.010818	0	34	30									
MAP1B	4131	broad.mit.edu	37	5	71494799	71494799	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr5:71494799C>T	uc003kbw.3	+	5	5858	c.5617C>T	c.(5617-5619)CAA>TAA	p.Q1873*	MAP1B_uc010iyw.1_Nonsense_Mutation_p.Q1890*|MAP1B_uc010iyx.1_Nonsense_Mutation_p.Q1747*|MAP1B_uc010iyy.1_Nonsense_Mutation_p.Q1747*	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1873						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		CTATGCCTATCAAAAGCCTGA	0.473		NaN											0	0	0	0.010818	0	29	7									
CHD1	1105	broad.mit.edu	37	5	98236691	98236691	+	Missense_Mutation	SNP	T	T	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr5:98236691T>C	uc003knf.2	-	6	831	c.683A>G	c.(682-684)GAT>GGT	p.D228G		NM_001270	NP_001261	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	228					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			lung(2)|ovary(1)|breast(1)|pancreas(1)	5		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	ACTTCTTTTATCATTATCATA	0.363		NaN											0	0	0	0.00499	0	15	20									
PPP2CA	5515	broad.mit.edu	37	5	133536147	133536147	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr5:133536147C>T	uc003kze.2	-	5	1015	c.617G>A	c.(616-618)CGT>CAT	p.R206H		NM_002715	NP_002706	P67775	PP2AA_HUMAN	protein phosphatase 2, catalytic subunit, alpha	206					ceramide metabolic process|inactivation of MAPK activity|induction of apoptosis|meiosis|negative regulation of cell growth|negative regulation of epithelial to mesenchymal transition|negative regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of protein serine/threonine kinase activity|protein dephosphorylation|regulation of cell adhesion|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction|spindle pole	metal ion binding|phosphoprotein phosphatase activity			ovary(2)|lung(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		Vitamin E(DB00163)	CCAACCACCACGGTCATCTGG	0.413		NaN											0	0	0	0.00874	0	36	12									
PURA	5813	broad.mit.edu	37	5	139494256	139494256	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr5:139494256C>T	uc003lfa.2	+	1	549	c.490C>T	c.(490-492)CGC>TGC	p.R164C		NM_005859	NP_005850	Q00577	PURA_HUMAN	purine-rich element binding protein A	164					DNA unwinding involved in replication|DNA-dependent DNA replication initiation	DNA replication factor A complex	double-stranded telomeric DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|single-stranded DNA binding|transcription factor binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGAGAACCAGCGCGGCCGCTT	0.692		NaN											0	0	0	0.001855	0	11	30									
WDR55	54853	broad.mit.edu	37	5	140048746	140048746	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr5:140048746G>A	uc003lgr.3	+	6	857	c.743G>A	c.(742-744)CGC>CAC	p.R248H	WDR55_uc011czl.1_Missense_Mutation_p.R87H	NM_017706	NP_060176	Q9H6Y2	WDR55_HUMAN	WD repeat domain 55	248					rRNA processing	cytoplasm|nucleolus				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACAAGTGACCGCTTTGCCCTG	0.532		NaN											0	0	0	0.00308	0	8	72									
PCDHA2	56146	broad.mit.edu	37	5	140175513	140175513	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr5:140175513G>A	uc003lhd.2	+	1	1070	c.964G>A	c.(964-966)GCA>ACA	p.A322T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Missense_Mutation_p.A322T|PCDHA2_uc011czy.1_Missense_Mutation_p.A322T	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	322	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCAGGTCACTGCAACTGACAA	0.378		NaN											0	0	0	0.010729	0	12	35									
PCDHB16	57717	broad.mit.edu	37	5	140563916	140563916	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr5:140563916C>T	uc003liv.2	+	1	2937	c.1782C>T	c.(1780-1782)GGC>GGT	p.G594G	PCDHB9_uc003liw.1_5'Flank	NM_020957	NP_066008	Q9NRJ7	PCDBG_HUMAN	protocadherin beta 16 precursor	594	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGGTGGACGGCGACTCGGGCC	0.706		NaN											0	0	0	0.001168	0	4	52									
PCDHB9	56127	broad.mit.edu	37	5	140569002	140569002	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr5:140569002C>T	uc003liw.1	+	3	2111	c.2111C>T	c.(2110-2112)TCG>TTG	p.S704L	PCDHB10_uc003lix.2_5'Flank	NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	704	Helical; (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTCCTCCTCTCGGTGCTCCTG	0.701		NaN											0	0	0	0.00361	0	99	204									
PCDHGB5	56101	broad.mit.edu	37	5	140779598	140779598	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr5:140779598G>A	uc003lkf.1	+	1	1904	c.1904G>A	c.(1903-1905)CGC>CAC	p.R635H	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc011daw.1_Missense_Mutation_p.R635H|PCDHGA9_uc011dax.1_5'Flank|PCDHGA9_uc003lkh.1_5'Flank	NM_018925	NP_061748	Q9Y5G0	PCDGH_HUMAN	protocadherin gamma subfamily B, 5 isoform 1	635	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACGCGGCCCGCCAGCGCCTG	0.687		NaN											0	0	0	0.00245	0	15	29									
DIAPH1	1729	broad.mit.edu	37	5	140953172	140953172	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr5:140953172G>A	uc003llb.3	-	16	2386	c.2245C>T	c.(2245-2247)CCA>TCA	p.P749S	DIAPH1_uc003llc.3_Missense_Mutation_p.P740S|DIAPH1_uc010jgc.1_Missense_Mutation_p.P188S	NM_005219	NP_005210	O60610	DIAP1_HUMAN	diaphanous 1 isoform 1	749	FH1.				regulation of microtubule-based process|sensory perception of sound	cytoplasm|cytoskeleton|ruffle membrane	actin binding|receptor binding|Rho GTPase binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGGGAGGTGGAGGCATACCC	0.587		NaN											0	0	0	0.003163	0	14	34									
ARHGAP26	23092	broad.mit.edu	37	5	142435652	142435652	+	Splice_Site	SNP	G	G	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr5:142435652G>T	uc011dbj.1	+	16	1467	c.1432_splice	c.e16+1	p.K478_splice	ARHGAP26_uc003lmt.2_Splice_Site_p.K478_splice|ARHGAP26_uc003lmw.2_Splice_Site_p.K478_splice	NM_015071	NP_055886	Q9UNA1	RHG26_HUMAN	GTPase regulator associated with the focal						actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			ovary(1)	1		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AAAGCAGCAAGTAAGTCTTTT	0.353		NaN											1	0	2.05212e-20	0.005524	2.21333e-20	33	55									
ARSI	340075	broad.mit.edu	37	5	149676860	149676860	+	Missense_Mutation	SNP	G	G	A	rs142267983		TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr5:149676860G>A	uc003lrv.2	-	2	2216	c.1627C>T	c.(1627-1629)CGT>TGT	p.R543C		NM_001012301	NP_001012301	Q5FYB1	ARSI_HUMAN	arylsulfatase family, member I precursor	543						endoplasmic reticulum|extracellular region	arylsulfatase activity|metal ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTCTTGCGACGACCCCGGGAG	0.547		NaN											0	0	0	0.00361	0	42	96									
ODZ2	57451	broad.mit.edu	37	5	167642220	167642220	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr5:167642220G>A	uc010jjd.2	+	21	3994	c.3994G>A	c.(3994-3996)GAA>AAA	p.E1332K	ODZ2_uc003lzr.3_Missense_Mutation_p.E1102K|ODZ2_uc003lzt.3_Missense_Mutation_p.E705K|ODZ2_uc010jje.2_Missense_Mutation_p.E596K	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		ACCCTTTGATGAAGCCCGCTG	0.557		NaN											0	0	0	0.00361	0	105	23									
RANBP17	64901	broad.mit.edu	37	5	170319554	170319554	+	Silent	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr5:170319554C>G	uc003mba.2	+	4	436	c.420C>G	c.(418-420)CTC>CTG	p.L140L	RANBP17_uc003max.1_RNA|RANBP17_uc003may.1_RNA|RANBP17_uc003maz.1_RNA|RANBP17_uc010jjr.1_RNA|RANBP17_uc003maw.2_Silent_p.L140L|RANBP17_uc011dew.1_Silent_p.L140L	NM_022897	NP_075048	Q9H2T7	RBP17_HUMAN	RAN binding protein 17	140					mRNA transport|protein import into nucleus|transmembrane transport	cytoplasm|nuclear pore	GTP binding|protein transporter activity			ovary(2)|central_nervous_system(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00751)|all_lung(126;0.0123)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			AGAAGTTTCTCCAGGTAAGAA	0.348		NaN	T	TRD@	ALL								0	0	0	0.009535	0	25	69									
RANBP17	64901	broad.mit.edu	37	5	170610195	170610195	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr5:170610195G>A	uc003mba.2	+	17	1906	c.1890G>A	c.(1888-1890)GTG>GTA	p.V630V	RANBP17_uc003mbb.2_Intron|RANBP17_uc003mbd.2_5'UTR|RANBP17_uc010jjs.2_RNA|RANBP17_uc003mbc.2_5'UTR	NM_022897	NP_075048	Q9H2T7	RBP17_HUMAN	RAN binding protein 17	630					mRNA transport|protein import into nucleus|transmembrane transport	cytoplasm|nuclear pore	GTP binding|protein transporter activity			ovary(2)|central_nervous_system(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00751)|all_lung(126;0.0123)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			AAAAACTTGTGAAGATAGATG	0.264		NaN	T	TRD@	ALL								0	0	0	0.002299	0	18	1									
BMP6	654	broad.mit.edu	37	6	7727603	7727603	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:7727603C>T	uc003mxu.3	+	1	593	c.415C>T	c.(415-417)CTG>TTG	p.L139L		NM_001718	NP_001709	P22004	BMP6_HUMAN	bone morphogenetic protein 6 preproprotein	139					BMP signaling pathway|cartilage development|growth|immune response|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	BMP receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity			large_intestine(2)|ovary(1)	3	Ovarian(93;0.0721)					CATGCTGGATCTGTACAACGC	0.597		NaN											0	0	0	0.012319	0	19	55									
BMP6	654	broad.mit.edu	37	6	7727750	7727750	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:7727750C>T	uc003mxu.3	+	1	740	c.562C>T	c.(562-564)CTG>TTG	p.L188L		NM_001718	NP_001709	P22004	BMP6_HUMAN	bone morphogenetic protein 6 preproprotein	188					BMP signaling pathway|cartilage development|growth|immune response|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	BMP receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity			large_intestine(2)|ovary(1)	3	Ovarian(93;0.0721)					CAAGAGCCTTCTGGCCCCCGG	0.711		NaN											0	0	0	0.004007	0	13	23									
TXNDC5	81567	broad.mit.edu	37	6	7891866	7891866	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:7891866G>A	uc003mxv.2	-	5	752	c.720C>T	c.(718-720)GTC>GTT	p.V240V	TXNDC5_uc003mxw.2_Silent_p.V197V|TXNDC5_uc010jnz.2_Silent_p.V132V|TXNDC5_uc010joa.1_Silent_p.V132V	NM_030810	NP_110437	Q8NBS9	TXND5_HUMAN	thioredoxin domain containing 5 isoform 1	240	Thioredoxin 2.				anti-apoptosis|cell redox homeostasis|cellular membrane organization|glycerol ether metabolic process|post-Golgi vesicle-mediated transport	endoplasmic reticulum lumen|lysosomal lumen	electron carrier activity|isomerase activity|protein disulfide oxidoreductase activity				0	Ovarian(93;0.0398)					TGCCAATCTTGACAGTTTCGG	0.493		NaN											0	0	0	0.00623	0	35	128									
RANBP9	10048	broad.mit.edu	37	6	13711709	13711709	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:13711709G>T	uc003nbb.2	-	1	88	c.29C>A	c.(28-30)CCG>CAG	p.P10Q		NM_005493	NP_005484	Q96S59	RANB9_HUMAN	RAN binding protein 9	10	Poly-Pro.				axon guidance|microtubule nucleation|protein complex assembly	cytosol|microtubule associated complex|nucleus	Ran GTPase binding			lung(1)|skin(1)	2	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.223)			ctgctgctgcggcggcggcgg	0.517		NaN											1	0	0.00448238	0.004482	0.00453746	8	69									
SOX4	6659	broad.mit.edu	37	6	21595158	21595158	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:21595158G>T	uc003ndi.2	+	1	1187	c.393G>T	c.(391-393)AGG>AGT	p.R131S		NM_003107	NP_003098	Q06945	SOX4_HUMAN	SRY (sex determining region Y)-box 4	131					canonical Wnt receptor signaling pathway|cardiac ventricle formation|cellular response to glucose stimulus|DNA damage response, detection of DNA damage|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|glial cell development|glial cell proliferation|limb bud formation|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of protein export from nucleus|negative regulation of protein ubiquitination|neural tube formation|neuroepithelial cell differentiation|noradrenergic neuron differentiation|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|positive regulation of insulin secretion|positive regulation of N-terminal peptidyl-lysine acetylation|positive regulation of translation|pro-B cell differentiation|protein stabilization|skeletal system development|spinal cord motor neuron differentiation|sympathetic nervous system development|T cell differentiation	mitochondrion|nucleus	core promoter sequence-specific DNA binding|protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription coactivator activity				0	Ovarian(93;0.163)		all cancers(50;0.0751)|Epithelial(50;0.155)			ACCGGCCCAGGAAGAAGGTGA	0.557		NaN											1	0	2.0095e-06	0.001984	2.06271e-06	5	215									
NRSN1	140767	broad.mit.edu	37	6	24145869	24145869	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:24145869G>A	uc010jpq.1	+	4	520	c.283G>A	c.(283-285)GAA>AAA	p.E95K		NM_080723	NP_542454	Q8IZ57	NRSN1_HUMAN	neurensin 1	95					nervous system development	growth cone|integral to membrane|neuronal cell body|transport vesicle					0						AGCATTTGGCGAAGCCGATTT	0.507		NaN											0	0	0	0.00361	0	47	208									
HIST1H2BE	8344	broad.mit.edu	37	6	26184245	26184245	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:26184245C>T	uc003ngt.2	+	1	222	c.222C>T	c.(220-222)ATC>ATT	p.I74I		NM_003523	NP_003514	P62807	H2B1C_HUMAN	histone cluster 1, H2be	74					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding				0						TCGAGCGCATCGCCGGCGAGG	0.607		NaN											0	0	0	0.00361	0	292	26									
BTN3A1	11119	broad.mit.edu	37	6	26408131	26408131	+	Missense_Mutation	SNP	C	C	G	rs140260146		TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:26408131C>G	uc003nhv.2	+	4	1034	c.666C>G	c.(664-666)ATC>ATG	p.I222M	BTN3A1_uc011dkj.1_Missense_Mutation_p.I222M|BTN3A1_uc011dkk.1_Missense_Mutation_p.I170M|BTN3A1_uc010jqj.2_Missense_Mutation_p.I222M	NM_007048	NP_008979	O00481	BT3A1_HUMAN	butyrophilin, subfamily 3, member A1 isoform a	222	Ig-like V-type 2.|Extracellular (Potential).				lipid metabolic process	integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2						CCTGTACCATCAGAAGTTCCC	0.557		NaN											0	0	0	0.00361	0	221	16									
BTN1A1	696	broad.mit.edu	37	6	26505305	26505305	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:26505305C>G	uc003nif.3	+	3	600	c.580C>G	c.(580-582)CCT>GCT	p.P194A		NM_001732	NP_001723	Q13410	BT1A1_HUMAN	butyrophilin, subfamily 1, member A1 precursor	194	Extracellular (Potential).|Ig-like V-type 2.					extracellular region|integral to plasma membrane	receptor activity			ovary(1)|skin(1)	2						GTCCAGGAATCCTGATGAAGA	0.502		NaN											0	0	0	0.00361	0	88	6									
HIST1H4I	8294	broad.mit.edu	37	6	27107240	27107240	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:27107240C>G	uc003niy.1	+	1	153	c.153C>G	c.(151-153)ATC>ATG	p.I51M	HIST1H2BK_uc003nix.1_Intron	NM_003495	NP_003486	P62805	H4_HUMAN	histone cluster 1, H4i	51					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			lung(1)	1						CTGGCCTCATCTATGAGGAGA	0.637		NaN	T	BCL6	NHL								0	0	0	0.00361	0	185	141									
BAT2	7916	broad.mit.edu	37	6	31591626	31591626	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:31591626C>T	uc003nvb.3	+	3	479	c.230C>T	c.(229-231)TCA>TTA	p.S77L	BAT2_uc011dnv.1_RNA|BAT2_uc003nvc.3_Missense_Mutation_p.S77L|BAT2_uc003nve.2_5'Flank	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	77	4 X 57 AA type A repeats.|1-1.					cytoplasm|nucleus	protein binding				0						CCCAATGTCTCACTAGTGCCA	0.547		NaN											0	0	0	0.004656	0	19	89									
PHF1	5252	broad.mit.edu	37	6	33380128	33380128	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:33380128C>T	uc003oeh.2	+	2	324	c.88C>T	c.(88-90)CGG>TGG	p.R30W	PHF1_uc011drh.1_RNA|PHF1_uc003oei.2_Missense_Mutation_p.R30W|PHF1_uc010jux.2_5'UTR	NM_024165	NP_077084	O43189	PHF1_HUMAN	PHD finger protein 1 isoform b	30					chromatin modification	nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Ovarian(999;0.0443)				CCCCAGGCCTCGGCTTTGGGA	0.607		NaN											0	0	0	0.002836	0	28	7									
FGD2	221472	broad.mit.edu	37	6	36982667	36982667	+	Splice_Site	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:36982667G>A	uc010jwp.1	+	8	1054	c.883_splice	c.e8-1	p.E295_splice	FGD2_uc003ong.2_Splice_Site_p.E17_splice|FGD2_uc011dtv.1_Splice_Site|FGD2_uc003oni.1_Splice_Site_p.E101_splice	NM_173558	NP_775829	Q7Z6J4	FGD2_HUMAN	FYVE, RhoGEF and PH domain containing 2						actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|early endosome membrane|Golgi apparatus|lamellipodium|nucleus|ruffle membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			upper_aerodigestive_tract(1)|lung(1)|pancreas(1)	3						CAACCCCCTAGGAGCGGCTGC	0.652		NaN											0	0	0	0.007291	0	24	292									
CYP39A1	51302	broad.mit.edu	37	6	46593206	46593206	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:46593206C>T	uc003oyf.1	-	7	1084	c.880G>A	c.(880-882)GAT>AAT	p.D294N	CYP39A1_uc011dwa.1_Missense_Mutation_p.D274N|CYP39A1_uc010jzd.1_Missense_Mutation_p.D122N	NM_016593	NP_057677	Q9NYL5	CP39A_HUMAN	cytochrome P450, family 39, subfamily A,	294					bile acid biosynthetic process|bile acid catabolic process|digestion|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	24-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity			ovary(1)	1						TTGTGGATATCAGGATGAGAA	0.343		NaN											0	0	0	0.00361	0	142	112									
PLA2G7	7941	broad.mit.edu	37	6	46682224	46682224	+	Missense_Mutation	SNP	A	A	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:46682224A>G	uc010jzf.2	-	5	712	c.443T>C	c.(442-444)GTT>GCT	p.V148A	PLA2G7_uc010jzg.1_Missense_Mutation_p.V148A|PLA2G7_uc011dwd.1_Missense_Mutation_p.V103A|PLA2G7_uc011dwe.1_Missense_Mutation_p.V21A	NM_005084	NP_005075	Q13093	PAFA_HUMAN	phospholipase A2, group VII	148					inflammatory response|lipid catabolic process	extracellular space	1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding				0			Lung(136;0.192)			ATGAGAAAAAACAACAAGTGG	0.368		NaN											0	0	0	0.00361	0	58	477									
KLHL31	401265	broad.mit.edu	37	6	53516582	53516582	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:53516582C>T	uc003pcb.3	-	3	1860	c.1719G>A	c.(1717-1719)TGG>TGA	p.W573*	uc003pcc.1_5'UTR	NM_001003760	NP_001003760	Q9H511	KLH31_HUMAN	kelch repeat and BTB (POZ) domain containing 1	573	Kelch 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent					ovary(1)	1	Lung NSC(77;0.0158)					CGCCCTCGTTCCAGCCCCCCA	0.687		NaN											0	0	0	0.004007	0	15	41									
KLHL31	401265	broad.mit.edu	37	6	53516760	53516760	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:53516760C>G	uc003pcb.3	-	3	1682	c.1541G>C	c.(1540-1542)AGA>ACA	p.R514T	uc003pcc.1_Missense_Mutation_p.S51C	NM_001003760	NP_001003760	Q9H511	KLH31_HUMAN	kelch repeat and BTB (POZ) domain containing 1	514					regulation of transcription, DNA-dependent|transcription, DNA-dependent					ovary(1)	1	Lung NSC(77;0.0158)					CACGTACACTCTGTCGCTCAG	0.716		NaN											0	0	0	0.000602	0	3	10									
DST	667	broad.mit.edu	37	6	56505039	56505039	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:56505039G>T	uc003pdf.2	-	17	2321	c.2293C>A	c.(2293-2295)CCC>ACC	p.P765T	DST_uc003pcz.3_Missense_Mutation_p.P587T|DST_uc011dxj.1_Missense_Mutation_p.P616T|DST_uc011dxk.1_Missense_Mutation_p.P627T|DST_uc011dxl.1_Missense_Mutation_p.P616T|DST_uc003pcy.3_Missense_Mutation_p.P261T|DST_uc003pdb.2_Missense_Mutation_p.P261T|DST_uc003pdc.3_Missense_Mutation_p.P261T|DST_uc003pdd.3_Missense_Mutation_p.P261T|DST_uc003pde.2_Missense_Mutation_p.P703T	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	587					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TTTAGAAGGGGTTTTCGGATC	0.368		NaN											1	0	8.12818e-05	0.001984	8.31751e-05	7	35									
DST	667	broad.mit.edu	37	6	56716381	56716381	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:56716381G>C	uc003pdf.2	-	4	467	c.439C>G	c.(439-441)CGC>GGC	p.R147G	DST_uc011dxj.1_Translation_Start_Site|DST_uc011dxk.1_Missense_Mutation_p.R9G|DST_uc011dxl.1_Translation_Start_Site	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	Error:Variant_position_missing_in_Q03001_after_alignment					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			ATAGAGCAGCGATAGGACGCG	0.478		NaN									OREG0017515	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004482	0	6	13									
PHF3	23469	broad.mit.edu	37	6	64416024	64416024	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:64416024C>T	uc003pep.1	+	11	3499	c.3473C>T	c.(3472-3474)GCA>GTA	p.A1158V	PHF3_uc010kah.1_Missense_Mutation_p.A972V|PHF3_uc003pen.2_Missense_Mutation_p.A1070V|PHF3_uc011dxs.1_Missense_Mutation_p.A427V	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	1158					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			ATAGCAGATGCATTATCTTCA	0.398		NaN											0	0	0	0.001368	0	12	27									
BAI3	577	broad.mit.edu	37	6	70034888	70034888	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:70034888G>A	uc003pev.3	+	21	3387	c.2939G>A	c.(2938-2940)AGA>AAA	p.R980K	BAI3_uc010kak.2_Missense_Mutation_p.R980K|BAI3_uc011dxx.1_Missense_Mutation_p.R186K|BAI3_uc003pex.1_Missense_Mutation_p.R110K	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	980	Cytoplasmic (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				CGGCTTATAAGAAAACGCTTT	0.398		NaN											0	0	0	0.008871	0	17	50									
KCNQ5	56479	broad.mit.edu	37	6	73904395	73904395	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:73904395G>A	uc003pgk.2	+	14	2404	c.2057G>A	c.(2056-2058)AGA>AAA	p.R686K	KCNQ5_uc011dyh.1_Missense_Mutation_p.R705K|KCNQ5_uc011dyi.1_Missense_Mutation_p.R696K|KCNQ5_uc010kat.2_Missense_Mutation_p.R677K|KCNQ5_uc011dyj.1_Missense_Mutation_p.R576K|KCNQ5_uc011dyk.1_Missense_Mutation_p.R436K	NM_019842	NP_062816	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like	686					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		AACATCTCGAGAGGCCTGCAG	0.488		NaN											0	0	0	0.00361	0	71	70									
DDX43	55510	broad.mit.edu	37	6	74119057	74119057	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:74119057G>A	uc003pgw.2	+	10	1610	c.1266G>A	c.(1264-1266)CAG>CAA	p.Q422Q		NM_018665	NP_061135	Q9NXZ2	DDX43_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 43	422	Helicase ATP-binding.					intracellular	ATP binding|ATP-dependent RNA helicase activity|RNA binding			ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4						CAGATAGGCAGACAGTTATGA	0.383		NaN											0	0	0	0.00361	0	47	138									
LCA5	167691	broad.mit.edu	37	6	80223183	80223183	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:80223183C>T	uc003pix.2	-	3	901	c.466G>A	c.(466-468)GAA>AAA	p.E156K	LCA5_uc003piy.2_Missense_Mutation_p.E156K|LCA5_uc011dyq.1_RNA|LCA5_uc011dyr.1_Missense_Mutation_p.E156K	NM_001122769	NP_001116241	Q86VQ0	LCA5_HUMAN	Leber congenital amaurosis 5	156	Potential.				protein transport	cilium axoneme|microtubule basal body	protein binding				0		all_cancers(76;3.32e-05)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.0176)		BRCA - Breast invasive adenocarcinoma(397;0.0657)		TGTGAGATTTCATTTTCGGCA	0.378		NaN											0	0	0	0.012319	0	18	16									
SLC35A1	10559	broad.mit.edu	37	6	88210332	88210332	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:88210332C>G	uc011dzj.1	+	3	380	c.301C>G	c.(301-303)CAG>GAG	p.Q101E	SLC35A1_uc003plx.2_RNA|SLC35A1_uc010kbw.2_5'UTR|SLC35A1_uc003plz.2_Intron|SLC35A1_uc011dzi.1_Intron|SLC35A1_uc003ply.2_RNA|SLC35A1_uc010kbx.2_Missense_Mutation_p.Q101E|SLC35A1_uc010kby.2_RNA	NM_006416	NP_006407	P78382	S35A1_HUMAN	solute carrier family 35 (CMP-sialic acid	101	Helical; (Potential).				carbohydrate metabolic process|protein modification process	Golgi membrane|integral to plasma membrane	CMP-N-acetylneuraminate transmembrane transporter activity|sugar:hydrogen symporter activity				0		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0429)		GTATGCTGTTCAGAACAACAT	0.413		NaN											0	0	0	0.004289	0	30	23									
RARS2	57038	broad.mit.edu	37	6	88299660	88299660	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:88299660G>A	uc003pme.2	-	1	76	c.16C>T	c.(16-18)CGC>TGC	p.R6C	ORC3L_uc011dzl.1_5'Flank|ORC3L_uc011dzm.1_5'Flank|ORC3L_uc011dzn.1_5'Flank|ORC3L_uc003pmg.2_5'Flank|ORC3L_uc003pmh.2_5'Flank|ORC3L_uc003pmi.2_5'Flank|ORC3L_uc011dzo.1_5'Flank|ORC3L_uc011dzp.1_5'Flank|RARS2_uc003pmb.2_5'UTR|RARS2_uc003pmc.2_5'UTR|RARS2_uc003pmd.2_5'UTR|RARS2_uc003pmf.2_RNA	NM_020320	NP_064716	Q5T160	SYRM_HUMAN	arginyl-tRNA synthetase 2, mitochondrial	6					arginyl-tRNA aminoacylation	mitochondrial matrix	arginine-tRNA ligase activity|ATP binding|protein binding			ovary(2)|central_nervous_system(1)	3		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0456)		ATAGCGCGGCGAAAGCCGCAC	0.672		NaN									OREG0031911	type=REGULATORY REGION|TFbs=RELA|Dataset=RELA (p65) ChIP-PET Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with paired-end diTag sequencing (ChIP-PET)	0	0	0	0.00361	0	45	25									
GJA10	84694	broad.mit.edu	37	6	90605283	90605283	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:90605283C>G	uc011eaa.1	+	1	1096	c.1096C>G	c.(1096-1098)CAG>GAG	p.Q366E		NM_032602	NP_115991	Q969M2	CXA10_HUMAN	gap junction protein, alpha 10	366	Cytoplasmic (Potential).				synaptic transmission	connexon complex|integral to membrane	gap junction channel activity				0		all_cancers(76;5.71e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.0915)		TACAATGTCTCAGTCCTGGCT	0.552		NaN											0	0	0	0.00361	0	95	65									
BACH2	60468	broad.mit.edu	37	6	90661329	90661329	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:90661329C>T	uc011eab.1	-	7	1305	c.496G>A	c.(496-498)GAA>AAA	p.E166K	BACH2_uc003pnw.2_Missense_Mutation_p.E166K|BACH2_uc010kch.2_Missense_Mutation_p.E166K	NM_021813	NP_068585	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper	166	Poly-Glu.					nucleus	protein dimerization activity|sequence-specific DNA binding			ovary(3)|pancreas(1)|lung(1)|skin(1)	6		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		TCCTCCTCTTCATCCTCCTCC	0.612		NaN											0	0	0	0.00361	0	57	41									
ZBTB24	9841	broad.mit.edu	37	6	109802504	109802504	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:109802504C>G	uc003ptl.1	-	2	894	c.726G>C	c.(724-726)AAG>AAC	p.K242N	ZBTB24_uc011ear.1_RNA|ZBTB24_uc010kds.1_Missense_Mutation_p.K242N|ZBTB24_uc010kdt.1_RNA|ZBTB24_uc003ptm.2_Missense_Mutation_p.K242N	NM_014797	NP_055612	O43167	ZBT24_HUMAN	zinc finger and BTB domain containing 24 isoform	242					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0154)|all cancers(137;0.0216)|OV - Ovarian serous cystadenocarcinoma(136;0.0242)|BRCA - Breast invasive adenocarcinoma(108;0.059)		CATCCTCGGTCTTGGGATCAT	0.463		NaN											0	0	0	0.00361	0	55	104									
TUBE1	51175	broad.mit.edu	37	6	112400898	112400898	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:112400898C>T	uc003pvq.2	-	6	500	c.386G>A	c.(385-387)AGA>AAA	p.R129K	TUBE1_uc003pvr.2_Missense_Mutation_p.R54K	NM_016262	NP_057346	Q9UJT0	TBE_HUMAN	tubulin, epsilon 1	129					centrosome cycle|microtubule-based movement|protein polymerization	microtubule|pericentriolar material	GTP binding|GTPase activity|structural constituent of cytoskeleton			ovary(1)	1		all_cancers(87;0.0101)|all_hematologic(75;0.000258)|Colorectal(196;0.0466)|all_epithelial(87;0.1)		all cancers(137;0.0217)|OV - Ovarian serous cystadenocarcinoma(136;0.0613)|Epithelial(106;0.0636)|GBM - Glioblastoma multiforme(226;0.0972)|BRCA - Breast invasive adenocarcinoma(108;0.246)		TGCCGACTTTCTGAATTTCTC	0.368		NaN											0	0	0	0.012319	0	20	28									
TUBE1	51175	broad.mit.edu	37	6	112400906	112400906	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:112400906C>A	uc003pvq.2	-	6	492	c.378G>T	c.(376-378)GAG>GAT	p.E126D	TUBE1_uc003pvr.2_Missense_Mutation_p.E51D	NM_016262	NP_057346	Q9UJT0	TBE_HUMAN	tubulin, epsilon 1	126					centrosome cycle|microtubule-based movement|protein polymerization	microtubule|pericentriolar material	GTP binding|GTPase activity|structural constituent of cytoskeleton			ovary(1)	1		all_cancers(87;0.0101)|all_hematologic(75;0.000258)|Colorectal(196;0.0466)|all_epithelial(87;0.1)		all cancers(137;0.0217)|OV - Ovarian serous cystadenocarcinoma(136;0.0613)|Epithelial(106;0.0636)|GBM - Glioblastoma multiforme(226;0.0972)|BRCA - Breast invasive adenocarcinoma(108;0.246)		TTCTGAATTTCTCTAAAATCT	0.358		NaN											1	0	1.01871e-10	0.008871	1.06056e-10	20	25									
LAMA4	3910	broad.mit.edu	37	6	112452258	112452258	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:112452258C>T	uc003pvu.2	-	29	4189	c.3880G>A	c.(3880-3882)GAT>AAT	p.D1294N	LAMA4_uc003pvv.2_Missense_Mutation_p.D1287N|LAMA4_uc003pvt.2_Missense_Mutation_p.D1287N	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	1294	Laminin G-like 3.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		CCCTTTACATCCATGATGACA	0.458		NaN											0	0	0	0.005443	0	23	42									
DSE	29940	broad.mit.edu	37	6	116757927	116757927	+	Missense_Mutation	SNP	A	A	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:116757927A>C	uc003pws.2	+	6	2490	c.2296A>C	c.(2296-2298)AAC>CAC	p.N766H	DSE_uc011ebg.1_Missense_Mutation_p.N785H|DSE_uc003pwt.2_Missense_Mutation_p.N766H|DSE_uc003pwu.2_Missense_Mutation_p.N433H	NM_001080976	NP_001074445	Q9UL01	DSE_HUMAN	dermatan sulfate epimerase precursor	766					dermatan sulfate biosynthetic process	endoplasmic reticulum|Golgi apparatus|integral to membrane	chondroitin-glucuronate 5-epimerase activity			ovary(1)	1		all_cancers(87;0.00019)|all_epithelial(87;0.000416)|Ovarian(999;0.133)|Colorectal(196;0.234)		Epithelial(106;0.00915)|OV - Ovarian serous cystadenocarcinoma(136;0.0149)|GBM - Glioblastoma multiforme(226;0.0189)|all cancers(137;0.0262)		CCGAGTCCGGAACACAGCTAG	0.478		NaN											0	0	0	0.00632	0	24	43									
LAMA2	3908	broad.mit.edu	37	6	129634083	129634083	+	Missense_Mutation	SNP	A	A	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:129634083A>T	uc003qbn.2	+	23	3357	c.3252A>T	c.(3250-3252)AAA>AAT	p.K1084N	LAMA2_uc003qbo.2_Missense_Mutation_p.K1084N	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1084	Laminin EGF-like 12.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GTCATCCAAAATTCTCTGGTG	0.473		NaN											0	0	0	0.010729	0	12	18									
HBS1L	10767	broad.mit.edu	37	6	135318567	135318567	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:135318567C>T	uc003qez.2	-	6	974	c.767G>A	c.(766-768)GGA>GAA	p.G256E	HBS1L_uc003qey.2_Missense_Mutation_p.G92E|HBS1L_uc011ecy.1_Intron|HBS1L_uc011ecz.1_Missense_Mutation_p.G92E|HBS1L_uc011eda.1_Missense_Mutation_p.G214E	NM_006620	NP_006611	Q9Y450	HBS1L_HUMAN	Hsp70 subfamily B suppressor 1-like protein	256					signal transduction		GTP binding|GTPase activity|translation elongation factor activity			skin(2)	2	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.0046)|GBM - Glioblastoma multiforme(68;0.00702)		CTGCTTCCCTCCTTGCCGCTT	0.542		NaN											0	0	0	0.004878	0	29	57									
MAP3K5	4217	broad.mit.edu	37	6	136882784	136882784	+	Splice_Site	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:136882784C>T	uc003qhc.2	-	28	4236	c.3875_splice	c.e28-1	p.E1292_splice	MAP3K5_uc011edj.1_Splice_Site_p.E539_splice	NM_005923	NP_005914	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase						activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			ovary(2)|skin(2)|lung(1)	5	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		TCAGGAATTTCTAGAACAGAA	0.358		NaN											0	0	0	0.004482	0	9	15									
LRP11	84918	broad.mit.edu	37	6	150174190	150174190	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:150174190G>A	uc003qng.2	-	2	1044	c.720C>T	c.(718-720)ATC>ATT	p.I240I	LRP11_uc003qnh.1_Silent_p.I240I	NM_032832	NP_116221	Q86VZ4	LRP11_HUMAN	low density lipoprotein receptor-related protein	240	PKD.|Extracellular (Potential).					integral to membrane	receptor activity				0		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;4.56e-12)|GBM - Glioblastoma multiforme(68;0.225)		CATACTGGACGATGGCGTGGT	0.562		NaN											0	0	0	0.00361	0	37	32									
SYNE1	23345	broad.mit.edu	37	6	152737832	152737832	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:152737832G>A	uc010kiw.2	-	41	6342	c.5740C>T	c.(5740-5742)CAA>TAA	p.Q1914*	SYNE1_uc003qot.3_Nonsense_Mutation_p.Q1921*|SYNE1_uc003qou.3_Nonsense_Mutation_p.Q1914*|SYNE1_uc010kjb.1_Nonsense_Mutation_p.Q1897*	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1914	Cytoplasmic (Potential).|Potential.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTAGCATTTTGAAGAGCATCA	0.458		NaN								HNSCC(10;0.0054)			0	0	0	0.006214	0	9	21									
SYNE1	23345	broad.mit.edu	37	6	152765587	152765587	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:152765587C>T	uc010kiw.2	-	30	4398	c.3796G>A	c.(3796-3798)GAA>AAA	p.E1266K	SYNE1_uc003qot.3_Missense_Mutation_p.E1273K|SYNE1_uc003qou.3_Missense_Mutation_p.E1266K|SYNE1_uc010kjb.1_Missense_Mutation_p.E1249K|SYNE1_uc003qow.2_Missense_Mutation_p.E561K|SYNE1_uc003qox.1_Missense_Mutation_p.E782K	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1266	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AACAGATTTTCAGTATCCAAG	0.368		NaN								HNSCC(10;0.0054)			0	0	0	0.012213	0	25	38									
SYNE1	23345	broad.mit.edu	37	6	152768689	152768689	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:152768689C>G	uc010kiw.2	-	29	4175	c.3573G>C	c.(3571-3573)TTG>TTC	p.L1191F	SYNE1_uc003qot.3_Missense_Mutation_p.L1198F|SYNE1_uc003qou.3_Missense_Mutation_p.L1191F|SYNE1_uc010kjb.1_Missense_Mutation_p.L1174F|SYNE1_uc003qow.2_Missense_Mutation_p.L486F|SYNE1_uc003qox.1_Missense_Mutation_p.L707F	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1191	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AAACTTCTGTCAAAACTTTCA	0.458		NaN								HNSCC(10;0.0054)			0	0	0	0.009535	0	26	41									
PAPOLB	56903	broad.mit.edu	37	7	4899851	4899851	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:4899851C>G	uc003snk.2	-	1	1775	c.1591G>C	c.(1591-1593)GAA>CAA	p.E531Q	RADIL_uc003sng.1_Intron|RADIL_uc011jwd.1_Intron|RADIL_uc003snj.1_Intron	NM_020144	NP_064529	Q9NRJ5	PAPOB_HUMAN	poly(A) polymerase beta (testis specific)	530					mRNA processing|RNA polyadenylation|transcription, DNA-dependent	nucleus	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity|RNA binding			ovary(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.089)|OV - Ovarian serous cystadenocarcinoma(56;2.06e-14)		ATGCTGTTTTCACAGCCTGCA	0.468		NaN											0	0	0	0.00361	0	54	44									
DNAH11	8701	broad.mit.edu	37	7	21840770	21840770	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:21840770C>T	uc003svc.2	+	63	10094	c.10063C>T	c.(10063-10065)CTG>TTG	p.L3355L		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3355	Potential.|Stalk (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						GGATCGAAATCTGAGCAGACT	0.373		NaN							Kartagener_syndrome				0	0	0	0.004672	0	3	10									
MPP6	51678	broad.mit.edu	37	7	24681456	24681456	+	Missense_Mutation	SNP	T	T	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:24681456T>G	uc003swx.2	+	4	538	c.239T>G	c.(238-240)TTG>TGG	p.L80W	MPP6_uc003swy.2_Missense_Mutation_p.L80W	NM_016447	NP_057531	Q9NZW5	MPP6_HUMAN	membrane protein, palmitoylated 6	80	L27 2.				protein complex assembly		protein binding				0						GTGGCAGAATTGGTTGGTATA	0.378		NaN											0	0	0	0.00245	0	11	113									
TAX1BP1	8887	broad.mit.edu	37	7	27825064	27825064	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:27825064G>C	uc003szl.2	+	7	966	c.808G>C	c.(808-810)GAA>CAA	p.E270Q	TAX1BP1_uc011jzo.1_Missense_Mutation_p.E270Q|TAX1BP1_uc003szk.2_Missense_Mutation_p.E270Q|TAX1BP1_uc011jzp.1_Missense_Mutation_p.E113Q	NM_006024	NP_006015	Q86VP1	TAXB1_HUMAN	Tax1 (human T-cell leukemia virus type I)	270	Potential.				anti-apoptosis|apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production	cytosol	identical protein binding|kinase binding|zinc ion binding			breast(1)	1			GBM - Glioblastoma multiforme(3;0.0823)			AGAACAACTTGAATGTCAGTT	0.214		NaN											0	0	0	0.00361	0	45	62									
NT5C3	51251	broad.mit.edu	37	7	33066465	33066465	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:33066465G>A	uc003tdk.2	-	2	293	c.216C>T	c.(214-216)ATC>ATT	p.I72I	AVL9_uc011kai.1_Intron|NT5C3_uc003tdi.2_Silent_p.I33I|NT5C3_uc003tdj.2_Silent_p.I33I	NM_001002010	NP_001002010	Q9H0P0	5NT3_HUMAN	5'-nucleotidase, cytosolic III isoform 1	72					nucleotide metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol|endoplasmic reticulum	2'-phosphotransferase activity|5'-nucleotidase activity|magnesium ion binding|nucleotide binding			ovary(1)	1			GBM - Glioblastoma multiforme(11;0.0894)			TAAGACCACAGATAATTTCTT	0.264		NaN											0	0	0	0.003163	0	13	63									
BBS9	27241	broad.mit.edu	37	7	33644572	33644572	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:33644572G>A	uc003tdn.1	+	22	3130	c.2617G>A	c.(2617-2619)GAG>AAG	p.E873K	BBS9_uc003tdo.1_Missense_Mutation_p.E838K|BBS9_uc003tdp.1_Missense_Mutation_p.E868K|BBS9_uc003tdq.1_Missense_Mutation_p.E833K|BBS9_uc010kwn.1_RNA|BBS9_uc003tdr.1_Missense_Mutation_p.E397K|BBS9_uc003tds.1_Missense_Mutation_p.E296K|BBS9_uc003tdt.2_Intron	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2	873					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)			TCTCACTGCAGAGACACCCAG	0.453		NaN							Bardet-Biedl_syndrome				0	0	0	0.004007	0	15	18									
POU6F2	11281	broad.mit.edu	37	7	39500145	39500145	+	Splice_Site	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:39500145G>A	uc003thb.1	+	9	1445	c.1403_splice	c.e9-1	p.N468_splice		NM_007252	NP_009183	P78424	PO6F2_HUMAN	POU class 6 homeobox 2 isoform 1						central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1						CATCTCCACAGATCCTCAAAC	0.453		NaN											0	0	0	0.005443	0	21	27									
BLVRA	644	broad.mit.edu	37	7	43830958	43830958	+	Missense_Mutation	SNP	A	A	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:43830958A>G	uc003tir.2	+	4	328	c.245A>G	c.(244-246)GAC>GGC	p.D82G	BLVRA_uc010kxv.2_Missense_Mutation_p.D82G	NM_000712	NP_000703	P53004	BIEA_HUMAN	biliverdin reductase A precursor	82					heme catabolic process	cytosol	biliverdin reductase activity|zinc ion binding			ovary(1)	1					NADH(DB00157)	AGCCATGAGGACTACATCAGG	0.323		NaN											0	0	0	0.00361	0	103	55									
H2AFV	94239	broad.mit.edu	37	7	44880509	44880509	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:44880509G>A	uc003tma.2	-	3	339	c.184C>T	c.(184-186)CTC>TTC	p.L62F	H2AFV_uc003tlz.2_Missense_Mutation_p.L62F|H2AFV_uc003tmb.2_Intron|H2AFV_uc003tmc.2_Missense_Mutation_p.L62F|H2AFV_uc003tmd.2_Missense_Mutation_p.L36F	NM_012412	NP_036544	Q71UI9	H2AV_HUMAN	H2A histone family, member V isoform 1	62					nucleosome assembly	nucleosome|nucleus	DNA binding				0						TCTGCAGTGAGGTACTCCAGA	0.502		NaN											0	0	0	0.00361	0	86	40									
TBRG4	9238	broad.mit.edu	37	7	45142089	45142089	+	Missense_Mutation	SNP	A	A	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:45142089A>C	uc003tmv.2	-	7	1304	c.1178T>G	c.(1177-1179)GTA>GGA	p.V393G	TBRG4_uc003tmu.2_Missense_Mutation_p.V218G|TBRG4_uc003tmw.2_Missense_Mutation_p.V283G|TBRG4_uc003tmx.2_Missense_Mutation_p.V283G|TBRG4_uc011kcd.1_Missense_Mutation_p.V404G	NM_004749	NP_004740	Q969Z0	TBRG4_HUMAN	cell cycle progression 2 protein isoform 1	393					apoptosis|cell cycle arrest|cellular respiration|G1 phase of mitotic cell cycle|positive regulation of cell proliferation	mitochondrion	ATP binding|protein binding|protein kinase activity				0						CTTCTCATGTACCTGGGCAAG	0.597		NaN											0	0	0	0.003954	0	24	168									
DDC	1644	broad.mit.edu	37	7	50537777	50537777	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:50537777G>C	uc003tpf.3	-	12	1220	c.1134C>G	c.(1132-1134)ATC>ATG	p.I378M	DDC_uc010kza.2_Missense_Mutation_p.I293M|DDC_uc003tpg.3_Missense_Mutation_p.I378M	NM_000790	NP_000781	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid	378					cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(2)	2	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	TCACCTTGCGGATATAAGCCT	0.338		NaN											0	0	0	0.009535	0	27	139									
GRB10	2887	broad.mit.edu	37	7	50737442	50737442	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:50737442G>C	uc003tpi.2	-	4	512	c.481C>G	c.(481-483)CCG>GCG	p.P161A	GRB10_uc003tph.3_Missense_Mutation_p.P103A|GRB10_uc003tpj.2_Missense_Mutation_p.P161A|GRB10_uc003tpk.2_Missense_Mutation_p.P161A|GRB10_uc010kzb.2_Missense_Mutation_p.P103A|GRB10_uc003tpl.2_Missense_Mutation_p.P155A|GRB10_uc003tpm.2_Missense_Mutation_p.P103A|GRB10_uc003tpn.2_Missense_Mutation_p.P103A	NM_005311	NP_005302	Q13322	GRB10_HUMAN	growth factor receptor-bound protein 10 isoform	161					insulin receptor signaling pathway|insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway	cytosol|plasma membrane	insulin receptor binding|insulin receptor binding|SH3/SH2 adaptor activity			lung(3)|ovary(2)|upper_aerodigestive_tract(1)	6	Glioma(55;0.08)|all_neural(89;0.245)					GCCTGGCTCGGAGGTAAAGAA	0.592		NaN							Russell-Silver_syndrome				0	0	0	0.00623	0	34	31									
ELN	2006	broad.mit.edu	37	7	73474260	73474260	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:73474260C>T	uc003tzw.2	+	23	1568	c.1477C>T	c.(1477-1479)CCT>TCT	p.P493S	RFC2_uc011kfa.1_Intron|ELN_uc003tzn.2_Missense_Mutation_p.P487S|ELN_uc003tzz.2_Missense_Mutation_p.P406S|ELN_uc003tzo.2_Missense_Mutation_p.P454S|ELN_uc003tzp.2_Missense_Mutation_p.P398S|ELN_uc003tzq.2_Missense_Mutation_p.P351S|ELN_uc003tzr.2_Intron|ELN_uc003tzs.2_Missense_Mutation_p.P468S|ELN_uc003tzt.2_Missense_Mutation_p.P492S|ELN_uc003tzu.2_Missense_Mutation_p.P473S|ELN_uc003tzv.2_Missense_Mutation_p.P458S|ELN_uc003tzx.2_Missense_Mutation_p.P477S|ELN_uc011kff.1_Missense_Mutation_p.P487S|ELN_uc003tzy.2_Missense_Mutation_p.P463S	NM_000501	NP_001075224	P15502	ELN_HUMAN	elastin isoform a precursor	516	Ala-rich.				blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			ovary(3)|pancreas(2)	5		Lung NSC(55;0.159)			Rofecoxib(DB00533)	TGGCGTGGCTCCTGGTGTCGG	0.547		NaN	T	PAX5	B-ALL		Supravalvular Aortic Stenosis|Cutis laxa |Williams-Beuren Syndrome						0	0	0	0.00361	0	130	179									
FGL2	10875	broad.mit.edu	37	7	76828885	76828885	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:76828885C>G	uc003ugb.2	-	1	266	c.226G>C	c.(226-228)GAG>CAG	p.E76Q	CCDC146_uc003ufz.1_Intron|CCDC146_uc003uga.2_Intron	NM_006682	NP_006673	Q14314	FGL2_HUMAN	fibrinogen-like 2 precursor	76	Potential.				signal transduction	fibrinogen complex	receptor binding			skin(2)	2						AACACCTCCTCGATCCTGCTG	0.507		NaN											0	0	0	0.009535	0	27	85									
SEMA3E	9723	broad.mit.edu	37	7	82997265	82997265	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:82997265C>T	uc003uhy.1	-	17	2431	c.1965G>A	c.(1963-1965)CAG>CAA	p.Q655Q		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	655	Ig-like C2-type.				axon guidance	extracellular space|membrane	receptor activity			ovary(3)	3		Medulloblastoma(109;0.109)				GCTCTACTGTCTGGCAAAAAT	0.443		NaN											0	0	0	0.009718	0	38	62									
ADAM22	53616	broad.mit.edu	37	7	87757967	87757967	+	Silent	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:87757967G>C	uc003ujn.2	+	9	808	c.729G>C	c.(727-729)CTG>CTC	p.L243L	ADAM22_uc003uji.1_Silent_p.L242L|ADAM22_uc003ujj.1_Silent_p.L243L|ADAM22_uc003ujk.1_Silent_p.L243L|ADAM22_uc003ujl.1_Silent_p.L243L|ADAM22_uc003ujm.2_Silent_p.L243L|ADAM22_uc003ujo.2_Silent_p.L243L|ADAM22_uc003ujp.1_Silent_p.L295L	NM_021723	NP_068369	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22 isoform 1	243	Peptidase M12B.|Extracellular (Potential).				cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			ACATTGAACTGATGATTGTGA	0.383		NaN											0	0	0	0.007835	0	31	51									
C7orf64	84060	broad.mit.edu	37	7	92158136	92158136	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:92158136G>A	uc003ulz.2	+	1	50	c.9G>A	c.(7-9)TCG>TCA	p.S3S	PEX1_uc003uly.2_5'Flank|PEX1_uc011khr.1_5'Flank|PEX1_uc010ley.2_5'Flank|PEX1_uc011khs.1_5'Flank|C7orf64_uc011khu.1_Silent_p.S3S|C7orf64_uc003uma.2_Silent_p.S3S	NM_032120	NP_115496	Q5RL73	CG064_HUMAN	hypothetical protein LOC84060	3							nucleotide binding			ovary(2)	2						AGATGGCGTCGAGCGGCGGGG	0.567		NaN											0	0	0	0.003271	0	28	35									
TRRAP	8295	broad.mit.edu	37	7	98522777	98522777	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:98522777G>A	uc003upp.2	+	22	3075	c.2866G>A	c.(2866-2868)GAG>AAG	p.E956K	TRRAP_uc011kis.1_Missense_Mutation_p.E956K|TRRAP_uc003upr.2_Missense_Mutation_p.E648K	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	956					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			CGCCAACACTGAGCCCTACTA	0.507		NaN											0	0	0	0.00361	0	44	68									
TRRAP	8295	broad.mit.edu	37	7	98534849	98534849	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:98534849G>A	uc003upp.2	+	29	4391	c.4182G>A	c.(4180-4182)CTG>CTA	p.L1394L	TRRAP_uc011kis.1_Silent_p.L1394L|TRRAP_uc003upr.2_Silent_p.L1086L	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	1394					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TCAAAGCCCTGAATTCCACCA	0.363		NaN											0	0	0	0.00361	0	49	203									
PILRA	29992	broad.mit.edu	37	7	99995535	99995535	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:99995535G>T	uc003uuo.1	+	4	919	c.707G>T	c.(706-708)AGG>ATG	p.R236M	PILRA_uc011kjo.1_Missense_Mutation_p.R163M|PILRA_uc003uup.1_Missense_Mutation_p.R163M|PILRA_uc003uuq.1_Intron	NM_013439	NP_038467	Q9UKJ1	PILRA_HUMAN	paired immunoglobulin-like type 2 receptor alpha	236	Cytoplasmic (Potential).				interspecies interaction between organisms	extracellular region|integral to membrane|plasma membrane	protein binding|receptor activity			skin(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					ACCCCAGCCAGGTGAGTGCTG	0.612		NaN											1	0	4.65686e-17	0.003755	4.98194e-17	32	126									
TFR2	7036	broad.mit.edu	37	7	100231073	100231073	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:100231073C>T	uc003uvv.1	-	4	621	c.580G>A	c.(580-582)GAC>AAC	p.D194N	TFR2_uc010lhc.1_5'Flank|TFR2_uc003uvu.1_Missense_Mutation_p.D23N	NM_003227	NP_003218	Q9UP52	TFR2_HUMAN	transferrin receptor 2	194	Extracellular (Potential).				cellular iron ion homeostasis|iron ion transport|proteolysis	cytoplasm|integral to plasma membrane	peptidase activity|transferrin receptor activity			ovary(1)|pancreas(1)	2	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					TAGTGCGTGTCGGTCCACACG	0.512		NaN											0	0	0	0.00333	0	20	29									
ZAN	7455	broad.mit.edu	37	7	100363105	100363105	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:100363105C>T	uc003uwj.2	+	23	4563	c.4398C>T	c.(4396-4398)TTC>TTT	p.F1466F	ZAN_uc003uwk.2_Silent_p.F1466F|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kkd.1_Silent_p.F43F	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	1466	TIL 2.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			ATCCGGGCTTCGTCCTCAGTG	0.627		NaN											0	0	0	0.004007	0	16	25									
FEZF1	389549	broad.mit.edu	37	7	121942239	121942239	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:121942239C>T	uc003vkd.2	-	4	1314	c.1240G>A	c.(1240-1242)GAC>AAC	p.D414N	FEZF1_uc003vkc.2_Missense_Mutation_p.D364N|uc010lko.1_5'Flank	NM_001024613	NP_001019784	A0PJY2	FEZF1_HUMAN	FEZ family zinc finger 1 isoform 1	414	C2H2-type 6.				cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)	3						TTCTTGAGGTCAAAGTTCCTG	0.527		NaN											0	0	0	0.010771	0	42	141									
IQUB	154865	broad.mit.edu	37	7	123092843	123092843	+	Nonsense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:123092843G>C	uc003vkn.2	-	13	2907	c.2330C>G	c.(2329-2331)TCA>TGA	p.S777*	IQUB_uc011kny.1_Nonsense_Mutation_p.S110*|IQUB_uc003vko.2_Nonsense_Mutation_p.S777*|IQUB_uc010lkt.2_RNA	NM_178827	NP_849149	Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	777										ovary(3)|large_intestine(1)	4						TGTTGTGTCTGAGTGATACTT	0.398		NaN											0	0	0	0.008871	0	18	19									
RBM28	55131	broad.mit.edu	37	7	127978389	127978389	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:127978389C>T	uc003vmp.2	-	5	571	c.456G>A	c.(454-456)AAG>AAA	p.K152K	RBM28_uc003vmo.2_5'Flank|RBM28_uc011koj.1_Intron|RBM28_uc011kok.1_Silent_p.K99K	NM_018077	NP_060547	Q9NW13	RBM28_HUMAN	RNA binding motif protein 28	152	RRM 2.				mRNA processing|RNA splicing	Golgi apparatus|nucleolus|spliceosomal complex	nucleotide binding|RNA binding			ovary(2)	2						AACCGCGCATCTTCCCATCTG	0.418		NaN											0	0	0	0.00499	0	14	51									
KIAA1147	57189	broad.mit.edu	37	7	141364706	141364706	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:141364706C>A	uc003vwk.2	-	7	1101	c.1101G>T	c.(1099-1101)CAG>CAT	p.Q367H		NM_001080392	NP_001073861	A4D1U4	LCHN_HUMAN	hypothetical protein LOC57189	367										ovary(1)	1	Melanoma(164;0.0171)					GCCACTACCTCTGCTCGTTGA	0.597		NaN											1	0	9.16793e-09	0.00499	9.48456e-09	11	19									
NOBOX	135935	broad.mit.edu	37	7	144097329	144097329	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:144097329C>T	uc011kue.1	-	5	921	c.921G>A	c.(919-921)CAG>CAA	p.Q307Q		NM_001080413	NP_001073882	O60393	NOBOX_HUMAN	NOBOX oogenesis homeobox	307	Homeobox.				cell differentiation|oogenesis	nucleus	sequence-specific DNA binding			ovary(1)	1	Melanoma(164;0.14)					CCCCCACCGTCTGGGCAATCT	0.552		NaN											0	0	0	0.002836	0	30	60									
NOS3	4846	broad.mit.edu	37	7	150696118	150696118	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:150696118G>A	uc003wif.2	+	8	1197	c.901G>A	c.(901-903)GAA>AAA	p.E301K	NOS3_uc011kuy.1_Missense_Mutation_p.E95K|NOS3_uc011kuz.1_Missense_Mutation_p.E301K|NOS3_uc011kva.1_Missense_Mutation_p.E301K|NOS3_uc011kvb.1_Missense_Mutation_p.E301K	NM_000603	NP_000594	P29474	NOS3_HUMAN	nitric oxide synthase 3 isoform 1	301	Interaction with NOSIP.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			central_nervous_system(5)|large_intestine(2)|skin(1)	8	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	TGATCCCCCAGAACTCTTCCT	0.657		NaN											0	0	0	0.00361	0	44	227									
ATG9B	285973	broad.mit.edu	37	7	150714325	150714325	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:150714325G>C	uc011kvc.1	-	9	2163	c.2087C>G	c.(2086-2088)TCT>TGT	p.S696C	ATG9B_uc003wig.3_RNA	NM_173681	NP_775952	Q674R7	ATG9B_HUMAN	ATG9 autophagy related 9 homolog B	696	Cytoplasmic (By similarity).				autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane				ovary(1)	1	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CGCACGCTGAGACAGCGAGGC	0.592		NaN											0	0	0	0.00632	0	23	31									
ATG9B	285973	broad.mit.edu	37	7	150714331	150714331	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:150714331G>A	uc011kvc.1	-	9	2157	c.2081C>T	c.(2080-2082)TCG>TTG	p.S694L	ATG9B_uc003wig.3_RNA	NM_173681	NP_775952	Q674R7	ATG9B_HUMAN	ATG9 autophagy related 9 homolog B	694	Cytoplasmic (By similarity).				autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane				ovary(1)	1	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CTGAGACAGCGAGGCCTCAGT	0.582		NaN											0	0	0	0.00632	0	24	35									
WDR60	55112	broad.mit.edu	37	7	158672547	158672547	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:158672547C>T	uc003woe.3	+	5	904	c.746C>T	c.(745-747)TCT>TTT	p.S249F	WDR60_uc010lqv.2_RNA	NM_018051	NP_060521	Q8WVS4	WDR60_HUMAN	WD repeat domain 60	249										ovary(2)|breast(1)|central_nervous_system(1)	4	Ovarian(565;0.152)	all_cancers(7;1.25e-09)|all_epithelial(9;0.000894)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)|STAD - Stomach adenocarcinoma(7;0.18)		AATTCATTCTCTGACAAAGGG	0.398		NaN											0	0	0	0.001368	0	12	11									
NEFM	4741	broad.mit.edu	37	8	24771416	24771416	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr8:24771416C>T	uc003xed.3	+	1	143	c.110C>T	c.(109-111)TCG>TTG	p.S37L	NEFM_uc011lac.1_Missense_Mutation_p.S37L|NEFM_uc010lue.2_5'Flank|uc010luc.1_3'UTR	NM_005382	NP_005373	P07197	NFM_HUMAN	neurofilament, medium polypeptide 150kDa isoform	37	Head.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(1)	1		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		GGCTTCCGCTCGCAGTCGTGG	0.697		NaN											0	0	0	0.012319	0	17	13									
CHRNA6	8973	broad.mit.edu	37	8	42611280	42611280	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr8:42611280C>T	uc003xpj.2	-	5	1108	c.1062G>A	c.(1060-1062)CTG>CTA	p.L354L	CHRNA6_uc011lcw.1_Silent_p.L339L	NM_004198	NP_004189	Q15825	ACHA6_HUMAN	cholinergic receptor, nicotinic, alpha 6	354	Cytoplasmic.					cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0	all_lung(13;3.33e-12)|Lung NSC(13;9.17e-11)|Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00439)|Lung NSC(58;0.0124)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	Lung(22;0.0252)|LUSC - Lung squamous cell carcinoma(45;0.0869)			GCCACCTCATCAGCAGGACCT	0.587		NaN											0	0	0	0.00361	0	53	38									
ST18	9705	broad.mit.edu	37	8	53062480	53062480	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr8:53062480G>C	uc003xqz.2	-	11	2020	c.1864C>G	c.(1864-1866)CGA>GGA	p.R622G	ST18_uc011ldq.1_Missense_Mutation_p.R269G|ST18_uc011ldr.1_Missense_Mutation_p.R587G|ST18_uc011lds.1_Missense_Mutation_p.R527G|ST18_uc003xra.2_Missense_Mutation_p.R622G|ST18_uc003xrb.2_Missense_Mutation_p.R622G	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	622						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				TCCAGGATTCGATTTTTTTTC	0.413		NaN											0	0	0	0.00499	0	16	77									
ST18	9705	broad.mit.edu	37	8	53084386	53084386	+	Silent	SNP	G	G	A	rs144551525		TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr8:53084386G>A	uc003xqz.2	-	5	1191	c.1035C>T	c.(1033-1035)ATC>ATT	p.I345I	ST18_uc011ldq.1_5'UTR|ST18_uc011ldr.1_Silent_p.I310I|ST18_uc011lds.1_Silent_p.I250I|ST18_uc003xra.2_Silent_p.I345I|ST18_uc003xrb.2_Silent_p.I345I	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	345						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				CACCCATGTCGATAACTTTGG	0.403		NaN											0	0	0	0.00361	0	37	159									
RP1	6101	broad.mit.edu	37	8	55537511	55537511	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr8:55537511G>A	uc003xsd.1	+	4	1217	c.1069G>A	c.(1069-1071)GGT>AGT	p.G357S	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	357					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			CAGTAAAACTGGTCCTTCTAA	0.363		NaN											0	0	0	0.00308	0	7	18									
RP1	6101	broad.mit.edu	37	8	55540055	55540055	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr8:55540055C>T	uc003xsd.1	+	4	3761	c.3613C>T	c.(3613-3615)CCA>TCA	p.P1205S	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1205					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			AGACATGGTTCCAATAGATCT	0.423		NaN											0	0	0	0.002299	0	20	77									
NCOA2	10499	broad.mit.edu	37	8	71036267	71036267	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr8:71036267C>T	uc003xyn.1	-	21	4307	c.4145G>A	c.(4144-4146)AGC>AAC	p.S1382N	NCOA2_uc011lfb.1_Missense_Mutation_p.S470N	NM_006540	NP_006531	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	1382					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)	lung(6)|soft_tissue(4)|breast(2)|skin(2)|ovary(1)|pancreas(1)	16	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			ACTGTACATGCTGGTGTTTGC	0.473		NaN	T	RUNXBP2	AML								0	0	0	0.00361	0	40	23									
FAM92A1	137392	broad.mit.edu	37	8	94740514	94740514	+	Missense_Mutation	SNP	T	T	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr8:94740514T>C	uc010maq.2	+	8	962	c.859T>C	c.(859-861)TTT>CTT	p.F287L	FAM92A1_uc003yfv.3_RNA|FAM92A1_uc003yfx.3_RNA|FAM92A1_uc003yfw.3_RNA|FAM92A1_uc010mar.2_Missense_Mutation_p.F94L	NM_145269	NP_660312	A1XBS5	F92A1_HUMAN	hypothetical protein LOC137392	287											0	Breast(36;2.4e-06)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			AGAAGAAAATTTTCTTAAGTA	0.328		NaN											0	0	0	0.010818	0	28	9									
ODF1	4956	broad.mit.edu	37	8	103572771	103572771	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr8:103572771C>G	uc003ykt.2	+	2	520	c.412C>G	c.(412-414)CAA>GAA	p.Q138E		NM_024410	NP_077721	Q14990	ODFP1_HUMAN	outer dense fiber of sperm tails 1	138					cell differentiation|multicellular organismal development|spermatogenesis	outer dense fiber	structural molecule activity			ovary(2)	2	all_cancers(14;2.76e-05)|all_epithelial(15;4.54e-08)|Lung NSC(17;4.08e-05)|all_lung(17;9.15e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000125)|STAD - Stomach adenocarcinoma(118;0.0826)			TGAACCCGATCAAGTCAAAGT	0.448		NaN											0	0	0	0.00361	0	130	55									
ODF1	4956	broad.mit.edu	37	8	103572958	103572958	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr8:103572958C>G	uc003ykt.2	+	2	707	c.599C>G	c.(598-600)TCT>TGT	p.S200C		NM_024410	NP_077721	Q14990	ODFP1_HUMAN	outer dense fiber of sperm tails 1	200					cell differentiation|multicellular organismal development|spermatogenesis	outer dense fiber	structural molecule activity			ovary(2)	2	all_cancers(14;2.76e-05)|all_epithelial(15;4.54e-08)|Lung NSC(17;4.08e-05)|all_lung(17;9.15e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000125)|STAD - Stomach adenocarcinoma(118;0.0826)			AAGATCGAGTCTCCTTGCTAC	0.343		NaN											0	0	0	0.00361	0	29	19									
ATP6V1C1	528	broad.mit.edu	37	8	104064968	104064968	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr8:104064968C>G	uc003ykz.3	+	6	636	c.391C>G	c.(391-393)CAG>GAG	p.Q131E	ATP6V1C1_uc010mbz.2_Missense_Mutation_p.Q56E|ATP6V1C1_uc003yla.2_Missense_Mutation_p.Q131E|ATP6V1C1_uc011lhl.1_Missense_Mutation_p.Q56E	NM_001695	NP_001686	P21283	VATC1_HUMAN	ATPase, H+ transporting, lysosomal V1 subunit	131					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|plasma membrane|proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism				0	Lung NSC(17;0.000427)|all_lung(17;0.000533)		OV - Ovarian serous cystadenocarcinoma(57;3.57e-05)|STAD - Stomach adenocarcinoma(118;0.133)			GGGAGTAACTCAGATTGATAA	0.318		NaN											0	0	0	0.008291	0	9	74									
GSDMC	56169	broad.mit.edu	37	8	130789625	130789625	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr8:130789625G>C	uc003ysr.2	-	2	1091	c.209C>G	c.(208-210)TCT>TGT	p.S70C		NM_031415	NP_113603	Q9BYG8	GSDMC_HUMAN	melanoma-derived leucine zipper, extra-nuclear	70						mitochondrion				ovary(2)|skin(1)	3						TAGGACTGAAGAACTTGGCTC	0.443		NaN											0	0	0	0.010771	0	34	73									
OC90	729330	broad.mit.edu	37	8	133044290	133044290	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr8:133044290C>A	uc003ytg.2	-	11	869	c.869G>T	c.(868-870)AGA>ATA	p.R290I	OC90_uc011lix.1_Missense_Mutation_p.R290I	NM_001080399	NP_001073868	Q02509	OC90_HUMAN	otoconin 90	306					lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			ovary(2)|skin(1)	3	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			GAAGGTGAATCTGTCACAGGC	0.547		NaN											1	0	1.47857e-17	0.00361	1.58694e-17	41	275									
TMEM71	137835	broad.mit.edu	37	8	133771110	133771110	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr8:133771110G>C	uc003ytp.2	-	2	245	c.16C>G	c.(16-18)CAA>GAA	p.Q6E	TMEM71_uc003ytn.2_Missense_Mutation_p.Q6E|TMEM71_uc003yto.2_Missense_Mutation_p.Q6E	NM_144649	NP_653250	Q6P5X7	TMM71_HUMAN	transmembrane protein 71 isoform 1	6						integral to membrane				ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			GACATCAGTTGAGATATTCGG	0.348		NaN											0	0	0	0.00361	0	50	254									
EPPK1	83481	broad.mit.edu	37	8	144940345	144940345	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr8:144940345C>T	uc003zaa.1	-	2	15100	c.15087G>A	c.(15085-15087)GTG>GTA	p.V5029V		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	5029	Plectin 64.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			AGGCCACGTCCACGGGCACGC	0.692		NaN											0	0	0	0.009718	0	34	663									
EPPK1	83481	broad.mit.edu	37	8	144943935	144943935	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr8:144943935C>G	uc003zaa.1	-	1	3500	c.3487G>C	c.(3487-3489)GAG>CAG	p.E1163Q		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	1163						cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TGCACGTCCTCCAGCAGGCCC	0.672		NaN											0	0	0	0.001168	0	5	23									
HSF1	3297	broad.mit.edu	37	8	145535411	145535411	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr8:145535411C>G	uc003zbt.3	+	8	919	c.749C>G	c.(748-750)TCC>TGC	p.S250C	HSF1_uc003zbu.3_RNA	NM_005526	NP_005517	Q00613	HSF1_HUMAN	heat shock transcription factor 1	250	Regulatory domain.					cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.94e-40)|Epithelial(56;1.12e-39)|all cancers(56;9.11e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0547)|Colorectal(110;0.055)			TACAGCAGCTCCAGCCTCTAC	0.692		NaN											0	0	0	0.00361	0	41	163									
KIAA1432	57589	broad.mit.edu	37	9	5772683	5772683	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:5772683G>A	uc003zji.2	+	23	3592	c.3499G>A	c.(3499-3501)GAG>AAG	p.E1167K	KIAA1432_uc003zjl.3_Missense_Mutation_p.E1130K|ERMP1_uc011lme.1_Intron	NM_020829	NP_065880	Q4ADV7	RIC1_HUMAN	connexin 43-interacting protein 150 isoform a	1246						integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		GTCAGAGCTGGAGCACATTTC	0.468		NaN											0	0	0	0.008871	0	19	128									
RANBP6	26953	broad.mit.edu	37	9	6015556	6015556	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:6015556C>G	uc003zjr.2	-	1	63	c.52G>C	c.(52-54)GAG>CAG	p.E18Q	RANBP6_uc011lmf.1_Missense_Mutation_p.E18Q|RANBP6_uc003zjs.2_5'UTR	NM_012416	NP_036548	O60518	RNBP6_HUMAN	RAN binding protein 6	18					protein transport	cytoplasm|nucleus	binding			ovary(3)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)		TGGTAAAACTCTTGCTTTTCT	0.552		NaN											0	0	0	0.003755	0	30	304									
KIAA1797	54914	broad.mit.edu	37	9	20946772	20946772	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:20946772G>A	uc003zog.1	+	32	3991	c.3628G>A	c.(3628-3630)GAG>AAG	p.E1210K	KIAA1797_uc003zoh.1_Missense_Mutation_p.E646K	NM_017794	NP_060264	Q5VW36	K1797_HUMAN	hypothetical protein LOC54914	1210						integral to membrane	binding			ovary(8)|breast(1)|kidney(1)	10				GBM - Glioblastoma multiforme(3;2.1e-125)|Lung(42;2.76e-14)|LUSC - Lung squamous cell carcinoma(42;1.99e-11)		TACAGAGGCTGAGGATGTTAT	0.448		NaN											0	0	0	0.00361	0	97	3									
IFNA4	3441	broad.mit.edu	37	9	21186998	21186998	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:21186998G>A	uc003zon.2	-	1	601	c.533C>T	c.(532-534)TCA>TTA	p.S178L		NM_021068	NP_066546	P05014	IFNA4_HUMAN	interferon, alpha 4 precursor	178					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(5;2.69e-202)|Lung(24;2.26e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		CAAGTTTGTTGAAAACGAGAG	0.378		NaN											0	0	0	0.00361	0	324	34									
TEK	7010	broad.mit.edu	37	9	27203074	27203074	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:27203074C>G	uc003zqi.3	+	13	2608	c.2166C>G	c.(2164-2166)AAC>AAG	p.N722K	TEK_uc011lno.1_Missense_Mutation_p.N679K|TEK_uc011lnp.1_Missense_Mutation_p.N575K|TEK_uc003zqj.1_Missense_Mutation_p.N656K	NM_000459	NP_000450	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial precursor	722	Extracellular (Potential).|Fibronectin type-III 3.				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			ovary(3)|central_nervous_system(3)|breast(3)|lung(2)|kidney(1)	12		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		GGTCAAGCAACCCAGCCTTTT	0.473		NaN											0	0	0	0.001855	0	10	79									
NOL6	65083	broad.mit.edu	37	9	33466615	33466615	+	Silent	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:33466615C>T	uc003zsz.2	-	16	2144	c.2043G>A	c.(2041-2043)CTG>CTA	p.L681L	SUGT1P1_uc010mjq.1_Intron|NOL6_uc003zsy.2_5'Flank|NOL6_uc003zta.2_Intron|NOL6_uc010mjv.2_Silent_p.L678L|NOL6_uc011lob.1_Silent_p.L629L|NOL6_uc003ztb.1_Silent_p.L681L	NM_022917	NP_075068	Q9H6R4	NOL6_HUMAN	nucleolar protein family 6 alpha isoform	681					rRNA processing	condensed nuclear chromosome|nucleolus	RNA binding	p.L681L(1)		ovary(2)	2			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.152)		CAGACACGGTCAGTGGGAGAC	0.622		NaN									OREG0019137	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00361	0	94	71									
GNE	10020	broad.mit.edu	37	9	36246323	36246323	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:36246323C>G	uc010mlh.2	-	3	536	c.321G>C	c.(319-321)ATG>ATC	p.M107I	CLTA_uc003zzf.1_Intron|GNE_uc010mlg.2_Missense_Mutation_p.M107I|GNE_uc011lpl.1_Missense_Mutation_p.M48I|GNE_uc010mli.2_Missense_Mutation_p.M138I|GNE_uc010mlj.2_Missense_Mutation_p.M102I	NM_005476	NP_005467	Q9Y223	GLCNE_HUMAN	UDP-N-acetylglucosamine-2-epimerase/N-	107	UDP-N-acetylglucosamine 2-epimerase.				cell adhesion|lipopolysaccharide biosynthetic process|N-acetylneuraminate metabolic process|UDP-N-acetylglucosamine metabolic process		ATP binding|N-acylmannosamine kinase activity|UDP-N-acetylglucosamine 2-epimerase activity				0			STAD - Stomach adenocarcinoma(86;0.228)			CATGAACAATCATGATATCAG	0.522		NaN											0	0	0	0.007413	0	18	108									
GNE	10020	broad.mit.edu	37	9	36246416	36246416	+	Silent	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:36246416C>G	uc010mlh.2	-	3	443	c.228G>C	c.(226-228)GTG>GTC	p.V76V	CLTA_uc003zzf.1_Intron|GNE_uc010mlg.2_Silent_p.V76V|GNE_uc011lpl.1_Silent_p.V17V|GNE_uc010mli.2_Silent_p.V107V|GNE_uc010mlj.2_Silent_p.V71V	NM_005476	NP_005467	Q9Y223	GLCNE_HUMAN	UDP-N-acetylglucosamine-2-epimerase/N-	76	UDP-N-acetylglucosamine 2-epimerase.				cell adhesion|lipopolysaccharide biosynthetic process|N-acetylneuraminate metabolic process|UDP-N-acetylglucosamine metabolic process		ATP binding|N-acylmannosamine kinase activity|UDP-N-acetylglucosamine 2-epimerase activity				0			STAD - Stomach adenocarcinoma(86;0.228)			CTTCTCCCCTCACAATTGTGT	0.438		NaN											0	0	0	0.007291	0	24	173									
GNE	10020	broad.mit.edu	37	9	36249349	36249349	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:36249349C>T	uc010mlh.2	-	2	219	c.4G>A	c.(4-6)GAG>AAG	p.E2K	CLTA_uc003zzf.1_Intron|GNE_uc010mlg.2_Missense_Mutation_p.E2K|GNE_uc011lpl.1_Intron|GNE_uc010mli.2_Missense_Mutation_p.E33K|GNE_uc010mlj.2_Intron	NM_005476	NP_005467	Q9Y223	GLCNE_HUMAN	UDP-N-acetylglucosamine-2-epimerase/N-	2	UDP-N-acetylglucosamine 2-epimerase.				cell adhesion|lipopolysaccharide biosynthetic process|N-acetylneuraminate metabolic process|UDP-N-acetylglucosamine metabolic process		ATP binding|N-acylmannosamine kinase activity|UDP-N-acetylglucosamine 2-epimerase activity				0			STAD - Stomach adenocarcinoma(86;0.228)			CCATTCTTCTCCATGATTTGC	0.353		NaN											0	0	0	0.007413	0	17	134									
DAPK1	1612	broad.mit.edu	37	9	90283556	90283556	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:90283556G>C	uc004apc.2	+	19	2106	c.1968G>C	c.(1966-1968)GAG>GAC	p.E656D	DAPK1_uc004apd.2_Missense_Mutation_p.E656D|DAPK1_uc011ltg.1_Missense_Mutation_p.E656D|DAPK1_uc011lth.1_Missense_Mutation_p.E393D|DAPK1_uc004apf.1_Missense_Mutation_p.E210D	NM_004938	NP_004929	P53355	DAPK1_HUMAN	death-associated protein kinase 1	656					apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			ovary(1)|breast(1)	2						AACAGCACGAGCACGTAGCAG	0.428		NaN							Chronic_Lymphocytic_Leukemia_Familial_Clustering_of				0	0	0	0.00361	0	58	209									
SPTLC1	10558	broad.mit.edu	37	9	94843181	94843181	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:94843181G>A	uc004arl.1	-	4	363	c.325C>T	c.(325-327)CTT>TTT	p.L109F	SPTLC1_uc011ltv.1_Missense_Mutation_p.L109F|SPTLC1_uc004arm.1_Missense_Mutation_p.L109F|SPTLC1_uc004arn.1_Missense_Mutation_p.L109F	NM_006415	NP_006406	O15269	SPTC1_HUMAN	serine palmitoyltransferase subunit 1 isoform a	109	Cytoplasmic (Potential).					integral to membrane|SPOTS complex	protein binding|pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			ovary(1)|breast(1)	2					L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	AACAATCCAAGAAAATTAAAT	0.373		NaN											0	0	0	0.008871	0	18	48									
FOXE1	2304	broad.mit.edu	37	9	100616407	100616407	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:100616407G>A	uc004axu.2	+	1	871	c.211G>A	c.(211-213)GAG>AAG	p.E71K		NM_004473	NP_004464	O00358	FOXE1_HUMAN	forkhead box E1	71	Fork-head.				cell migration|embryonic organ morphogenesis|hair follicle morphogenesis|hard palate development|lens morphogenesis in camera-type eye|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|peripheral nervous system development|pharynx development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|soft palate development|thymus development|thyroid gland development|thyroid hormone generation	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0		Acute lymphoblastic leukemia(62;0.158)				GCACGCGCCCGAGCGCCGCCT	0.572		NaN											0	0	0	0.00245	0	12	14									
TMEM38B	55151	broad.mit.edu	37	9	108536171	108536171	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:108536171C>T	uc004bcu.1	+	6	803	c.686C>T	c.(685-687)TCT>TTT	p.S229F	TMEM38B_uc010mtn.1_3'UTR	NM_018112	NP_060582	Q9NVV0	TM38B_HUMAN	transmembrane protein 38B	229	Cytoplasmic (Potential).					integral to membrane|nuclear membrane|sarcoplasmic reticulum membrane	potassium channel activity			ovary(1)|skin(1)	2						ACACAGACTTCTACTATGACA	0.358		NaN											0	0	0	0.009535	0	23	73									
IKBKAP	8518	broad.mit.edu	37	9	111659293	111659293	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:111659293G>T	uc004bdm.3	-	24	3047	c.2527C>A	c.(2527-2529)CAT>AAT	p.H843N	IKBKAP_uc004bdl.2_Missense_Mutation_p.H494N|IKBKAP_uc011lwc.1_Missense_Mutation_p.H729N|IKBKAP_uc010mtq.2_Missense_Mutation_p.H494N	NM_003640	NP_003631	O95163	ELP1_HUMAN	inhibitor of kappa light polypeptide gene	843					immune response|protein complex assembly|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding|signal transducer activity			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	7						TTCTTTACATGAGATGTAAGT	0.433		NaN											1	0	3.8784e-16	0.012319	4.12237e-16	17	76									
ZFP37	7539	broad.mit.edu	37	9	115805645	115805645	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:115805645G>A	uc004bgm.1	-	4	1281	c.1253C>T	c.(1252-1254)TCA>TTA	p.S418L	ZFP37_uc011lwz.1_Missense_Mutation_p.S433L|ZFP37_uc011lxa.1_Missense_Mutation_p.S419L	NM_003408	NP_003399	Q9Y6Q3	ZFP37_HUMAN	zinc finger protein 37 homolog	418	C2H2-type 5.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						GGTAAGAGATGAGTTATACCT	0.388		NaN											0	0	0	0.00361	0	49	36									
ZFP37	7539	broad.mit.edu	37	9	115806039	115806039	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:115806039G>A	uc004bgm.1	-	4	887	c.859C>T	c.(859-861)CAA>TAA	p.Q287*	ZFP37_uc011lwz.1_Nonsense_Mutation_p.Q302*|ZFP37_uc011lxa.1_Nonsense_Mutation_p.Q288*	NM_003408	NP_003399	Q9Y6Q3	ZFP37_HUMAN	zinc finger protein 37 homolog	287						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						ACACAAGCTTGAGGTTTTTCA	0.403		NaN											0	0	0	0.00361	0	61	51									
TRIM32	22954	broad.mit.edu	37	9	119461344	119461344	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:119461344G>A	uc004bjx.2	+	2	1481	c.1323G>A	c.(1321-1323)CTG>CTA	p.L441L	ASTN2_uc004bjr.1_Intron|ASTN2_uc004bjs.1_Intron|ASTN2_uc004bjt.1_Intron|TRIM32_uc004bjw.2_Silent_p.L441L	NM_001099679	NP_001093149	Q13049	TRI32_HUMAN	tripartite motif-containing 32	441	NHL 2.				fat cell differentiation|innate immune response|negative regulation of apoptosis|negative regulation of fibroblast proliferation|positive regulation of cell cycle|positive regulation of cell growth|positive regulation of cell migration|positive regulation of neurogenesis|positive regulation of neuron differentiation|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein catabolic process|positive regulation of proteolysis|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to tumor necrosis factor|response to UV	nucleus	myosin binding|protein self-association|RNA binding|Tat protein binding|transcription coactivator activity|translation initiation factor binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(2)|kidney(1)	3						GCCAGGGGCTGATTGGTGTGA	0.547		NaN							Bardet-Biedl_syndrome				0	0	0	0.00361	0	63	211									
DAB2IP	153090	broad.mit.edu	37	9	124535708	124535708	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:124535708G>A	uc004bln.2	+	12	2886	c.2817G>A	c.(2815-2817)CTG>CTA	p.L939L	DAB2IP_uc004blo.2_Silent_p.L843L|DAB2IP_uc004blp.2_Silent_p.L372L	NM_032552	NP_115941	Q5VWQ8	DAB2P_HUMAN	disabled homolog 2 interacting protein isoform	967					activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			ovary(1)|central_nervous_system(1)	2						GTACCCGCCTGAGGCAGCAGT	0.657		NaN											0	0	0	0.012319	0	16	8									
LMX1B	4010	broad.mit.edu	37	9	129455807	129455807	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:129455807G>C	uc004bqj.2	+	5	727	c.677G>C	c.(676-678)CGA>CCA	p.R226P	LMX1B_uc004bqi.2_Missense_Mutation_p.R226P|LMX1B_uc011maa.1_Missense_Mutation_p.R226P	NM_002316	NP_002307	O60663	LMX1B_HUMAN	LIM homeobox transcription factor 1, beta	226	Homeobox.		R -> P (in NPS).		dorsal/ventral pattern formation|in utero embryonic development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AGCCAGGTCCGAGAGACACTG	0.612		NaN							Nail-Patella_Syndrome				0	0	0	0.00361	0	48	39									
RALGPS1	9649	broad.mit.edu	37	9	129728131	129728131	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:129728131C>A	uc004bqo.1	+	3	333	c.66C>A	c.(64-66)AGC>AGA	p.S22R	RALGPS1_uc011mab.1_Missense_Mutation_p.S22R|RALGPS1_uc011mac.1_Missense_Mutation_p.S22R|RALGPS1_uc004bqq.3_Missense_Mutation_p.S22R	NM_014636	NP_055451	Q5JS13	RGPS1_HUMAN	Ral GEF with PH domain and SH3 binding motif 1	22	Poly-Ser.				small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity			ovary(1)	1						AGGGCAGCAGCAGCTCGGACT	0.542		NaN											1	0	0.000375601	0.00278	0.000383754	19	77									
RALGPS1	9649	broad.mit.edu	37	9	129958857	129958857	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:129958857G>A	uc004bqo.1	+	13	1409	c.1142G>A	c.(1141-1143)CGA>CAA	p.R381Q	RALGPS1_uc011mac.1_Intron|RALGPS1_uc004bqq.3_Intron	NM_014636	NP_055451	Q5JS13	RGPS1_HUMAN	Ral GEF with PH domain and SH3 binding motif 1	381					small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity			ovary(1)	1						CGCAGCCCCCGAAGGGGCCTG	0.577		NaN											0	0	0	0.004878	0	31	75									
GARNL3	84253	broad.mit.edu	37	9	130152935	130152935	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:130152935G>T	uc011mae.1	+	27	3160	c.2759G>T	c.(2758-2760)GGT>GTT	p.G920V	GARNL3_uc011mad.1_Missense_Mutation_p.G898V|GARNL3_uc010mxi.2_Missense_Mutation_p.G150V	NM_032293	NP_115669	Q5VVW2	GARL3_HUMAN	GTPase activating Rap/RanGAP domain-like 3	920					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						TCGGATGAAGGTGGACCCAAG	0.537		NaN											1	0	2.70572e-37	0.00361	2.94236e-37	79	71									
LRSAM1	90678	broad.mit.edu	37	9	130265177	130265177	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:130265177G>A	uc004brb.1	+	26	2516	c.2171G>A	c.(2170-2172)TGA>TAA	p.*724*	LRSAM1_uc010mxk.1_Silent_p.*697*|LRSAM1_uc004brc.1_Silent_p.*724*|LRSAM1_uc004brd.1_Silent_p.*724*|LRSAM1_uc004bre.1_Silent_p.*304*|LRSAM1_uc004brg.1_Silent_p.*155*	NM_001005373	NP_001005373	Q6UWE0	LRSM1_HUMAN	leucine rich repeat and sterile alpha motif	724					negative regulation of endocytosis|non-lytic virus budding|protein autoubiquitination|protein catabolic process|protein polyubiquitination|protein transport|ubiquitin-dependent endocytosis	cytoplasm|extracellular region|membrane part	hormone activity|ubiquitin-protein ligase activity|zinc ion binding				0						CACAGCAGCTGAGTGCTGCCC	0.697		NaN											0	0	0	0.00308	0	8	6									
TTC16	158248	broad.mit.edu	37	9	130489656	130489656	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:130489656C>T	uc004brq.1	+	12	1743	c.1676C>T	c.(1675-1677)CCT>CTT	p.P559L	PTRH1_uc011mah.1_5'Flank|TTC16_uc011mai.1_Missense_Mutation_p.P546L|TTC16_uc004brr.1_Missense_Mutation_p.P409L|TTC16_uc010mxn.1_Missense_Mutation_p.P155L	NM_144965	NP_659402	Q8NEE8	TTC16_HUMAN	tetratricopeptide repeat domain 16	559							binding				0						AAGGCCACCCCTGAGATTCCG	0.493		NaN											0	0	0	0.007413	0	15	11									
SARDH	1757	broad.mit.edu	37	9	136531911	136531911	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:136531911G>A	uc004cep.3	-	20	2711	c.2577C>T	c.(2575-2577)TTC>TTT	p.F859F	SARDH_uc004ceo.2_Silent_p.F859F|SARDH_uc011mdn.1_Silent_p.F859F|SARDH_uc011mdo.1_Silent_p.F691F|SARDH_uc004cen.2_Silent_p.F309F	NM_001134707	NP_001128179	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase precursor	859					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity				0				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		TGTCGATGGCGAACCCAAAGT	0.597		NaN											0	0	0	0.004672	0	3	11									
KCNT1	57582	broad.mit.edu	37	9	138606490	138606490	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:138606490G>A	uc011mdq.1	+	2	252	c.178G>A	c.(178-180)GAG>AAG	p.E60K	KCNT1_uc011mdr.1_5'UTR|KCNT1_uc010nbf.2_Intron	NM_020822	NP_065873	Q5JUK3	KCNT1_HUMAN	potassium channel, subfamily T, member 1	60						membrane	binding|calcium-activated potassium channel activity			large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		CCTGGACTCCGAGGTGCTGCC	0.716		NaN											0	0	0	0.004656	0	19	39									
C9orf142	286257	broad.mit.edu	37	9	139887394	139887394	+	Silent	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:139887394G>C	uc004cki.2	+	3	224	c.198G>C	c.(196-198)CTG>CTC	p.L66L		NM_183241	NP_899064	Q9BUH6	CI142_HUMAN	hypothetical protein LOC286257	66											0	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		GTTTTGGCCTGAGTGCGGCTG	0.662		NaN											0	0	0	0.004878	0	30	130									
BCOR	54880	broad.mit.edu	37	X	39930340	39930340	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chrX:39930340C>T	uc004den.3	-	6	3416	c.3124G>A	c.(3124-3126)GAG>AAG	p.E1042K	BCOR_uc004dep.3_Missense_Mutation_p.E1042K|BCOR_uc004deo.3_Missense_Mutation_p.E1024K|BCOR_uc004dem.3_Missense_Mutation_p.E1042K	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	1042					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						TTGCACATCTCGGAGTCTTTG	0.488		NaN											0	0	0	0.009535	0	30	2									
CHST7	56548	broad.mit.edu	37	X	46434158	46434158	+	Silent	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chrX:46434158G>A	uc004dgt.2	+	1	967	c.792G>A	c.(790-792)TTG>TTA	p.L264L		NM_019886	NP_063939	Q9NS84	CHST7_HUMAN	chondroitin 6-sulfotransferase 7	264	Lumenal (Potential).				chondroitin sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	chondroitin 6-sulfotransferase activity|N-acetylglucosamine 6-O-sulfotransferase activity			breast(3)	3						TGCCCCTGTTGCGTGATCCAG	0.657		NaN											0	0	0	0.004672	0	3	12									
ITIH5L	347365	broad.mit.edu	37	X	54783526	54783526	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chrX:54783526G>T	uc004dtj.2	-	8	3011	c.2981C>A	c.(2980-2982)CCT>CAT	p.P994H		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	994	Pro-rich.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						GATGGCCTCAGGGAGGATGCT	0.547		NaN											1	0	1.00905e-13	0.008871	1.06394e-13	18	22									
ITGB1BP2	26548	broad.mit.edu	37	X	70521663	70521663	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chrX:70521663C>G	uc004dzr.1	+	1	36	c.7C>G	c.(7-9)CTA>GTA	p.L3V	BCYRN1_uc011mpt.1_Intron|ITGB1BP2_uc004dzs.1_5'UTR	NM_012278	NP_036410	Q9UKP3	ITBP2_HUMAN	integrin beta 1 binding protein 2	3					muscle organ development|signal transduction		SH3 domain binding			ovary(1)	1	Renal(35;0.156)					TTCCATGTCTCTACTCTGTCG	0.507		NaN											0	0	0	0.00361	0	46	1									
SLC16A2	6567	broad.mit.edu	37	X	73745728	73745728	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chrX:73745728G>T	uc004ebt.2	+	4	1558	c.1392G>T	c.(1390-1392)CAG>CAT	p.Q464H	SLC16A2_uc010nlr.1_Missense_Mutation_p.Q139H	NM_006517	NP_006508	P36021	MOT8_HUMAN	solute carrier family 16, member 2	390	Helical; (Potential).					integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity			breast(2)|ovary(1)	3					Pyruvic acid(DB00119)	TCTACTTGCAGGTGAGTGTGA	0.488		NaN											1	0	1.50039e-11	0.012319	1.56697e-11	20	23									
CSTF2	1478	broad.mit.edu	37	X	100088252	100088252	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chrX:100088252G>A	uc004egh.2	+	11	1349	c.1291G>A	c.(1291-1293)GAG>AAG	p.E431K	CSTF2_uc010nnd.2_Missense_Mutation_p.E451K|CSTF2_uc004egi.2_Missense_Mutation_p.E414K	NM_001325	NP_001316	P33240	CSTF2_HUMAN	cleavage stimulation factor subunit 2	431	5; approximate.|12 X 5 AA tandem repeats of M-E-A-R-[AG].				mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cleavage body|mRNA cleavage and polyadenylation specificity factor complex	nucleotide binding|protein binding|protein binding|RNA binding			skin(1)	1						CAGAGGATTAGAGGCCCGTGC	0.587		NaN											0	0	0	0.00499	0	14	3									
ARMCX5	64860	broad.mit.edu	37	X	101857861	101857861	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chrX:101857861G>C	uc004ejg.2	+	6	1673	c.792G>C	c.(790-792)TTG>TTC	p.L264F	ARMCX5_uc004ejh.2_Missense_Mutation_p.L264F	NM_022838	NP_073749	Q6P1M9	ARMX5_HUMAN	armadillo repeat containing, X-linked 5	264							binding			ovary(1)	1						TTCGACCTTTGACCAAGATCC	0.483		NaN											0	0	0	0.007835	0	30	52									
H2BFWT	158983	broad.mit.edu	37	X	103267744	103267744	+	Silent	SNP	G	G	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chrX:103267744G>C	uc004elr.2	-	1	513	c.489C>G	c.(487-489)CTC>CTG	p.L163L		NM_001002916	NP_001002916	Q7Z2G1	H2BWT_HUMAN	H2B histone family, member W, testis-specific	163					nucleosome assembly	nuclear membrane|nucleosome	DNA binding			ovary(1)	1						TGGTGTACCTGAGGACAGCCT	0.632		NaN											0	0	0	0.005524	0	34	7									
GPR101	83550	broad.mit.edu	37	X	136112978	136112978	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chrX:136112978C>A	uc011mwh.1	-	1	856	c.856G>T	c.(856-858)GCC>TCC	p.A286S		NM_054021	NP_473362	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	286	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					CCTTCCTTGGCCTTCAGGCTG	0.612		NaN											1	0	7.28744e-38	0.00361	7.93789e-38	89	77									
PLXNB3	5365	broad.mit.edu	37	X	153044065	153044065	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chrX:153044065C>G	uc004fii.2	+	35	5735	c.5561C>G	c.(5560-5562)TCT>TGT	p.S1854C	PLXNB3_uc010nuk.2_Missense_Mutation_p.S1877C|PLXNB3_uc011mzd.1_Missense_Mutation_p.S1493C|SRPK3_uc004fik.2_5'UTR|SRPK3_uc010nul.2_5'Flank|SRPK3_uc004fin.2_5'Flank|SRPK3_uc004fil.2_5'Flank|SRPK3_uc004fim.2_5'Flank	NM_005393	NP_005384	Q9ULL4	PLXB3_HUMAN	plexin B3 isoform 1	1854	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			lung(1)	1	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					AACTACACTTCTGCTCCCCAC	0.612		NaN											0	0	0	0.000602	0	4	8									
BARHL2	343472	broad.mit.edu	37	1	91182377	91182377	+	Frame_Shift_Del	DEL	G	G	-			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:91182377delG	uc001dns.2	-	1	418	c.376delC	c.(376-378)CAGfs	p.Q126fs		NM_020063	NP_064447	Q9NY43	BARH2_HUMAN	BarH-like homeobox 2	126	Gln/Pro-rich.					nucleus	sequence-specific DNA binding			ovary(1)	1		all_lung(203;0.0263)|Lung SC(238;0.128)		all cancers(265;0.000897)|Epithelial(280;0.00516)|OV - Ovarian serous cystadenocarcinoma(397;0.211)		CCCAGCTGCTGGGGGggcggc	0.423		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---	---							
SLAMF1	6504	broad.mit.edu	37	1	160589601	160589601	+	Frame_Shift_Del	DEL	T	T	-			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:160589601delT	uc001fwl.3	-	5	1175	c.829delA	c.(829-831)AGCfs	p.S277fs	SLAMF1_uc010pjk.1_Intron|SLAMF1_uc010pjl.1_Intron|SLAMF1_uc010pjm.1_Intron	NM_003037	NP_003028	Q13291	SLAF1_HUMAN	signaling lymphocytic activation molecule family	277	Cytoplasmic (Potential).|Ig-like V-type.				interspecies interaction between organisms|lymphocyte activation|positive regulation of cell proliferation	integral to membrane	antigen binding|transmembrane receptor activity			ovary(1)|breast(1)	2	all_cancers(52;4.94e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			ATCGTAAGGCTTTTTTTTTCC	0.433		NaN											NaN	NaN	NaN	NaN	NaN	7	488	---	---							
TFAM	7019	broad.mit.edu	37	10	60148570	60148570	+	Frame_Shift_Del	DEL	A	A	-	rs78912196		TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr10:60148570delA	uc001jkf.2	+	4	564	c.432delA	c.(430-432)ACAfs	p.T144fs	TFAM_uc001jkg.2_RNA|TFAM_uc001jkh.2_Frame_Shift_Del_p.T144fs	NM_003201	NP_003192	Q00059	TFAM_HUMAN	transcription factor A, mitochondrial precursor	144					DNA-dependent DNA replication|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase I promoter|transcription initiation from mitochondrial promoter	mitochondrial nucleoid	mitochondrial light strand promoter sense binding|protein binding|sequence-specific DNA binding transcription factor activity				0						AAGCTATGACAAAAAAAAAAG	0.269		NaN											NaN	NaN	NaN	NaN	NaN	8	26	---	---							
ZMIZ1	57178	broad.mit.edu	37	10	81052006	81052026	+	In_Frame_Del	DEL	GCAGCAGCGGCAGTGGCAGCA	GCAGCAGCGGCAGTGGCAGCA	-			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr10:81052006_81052026delGCAGCAGCGGCAGTGGCAGCA	uc001kaf.2	+	11	1422_1442	c.850_870delGCAGCAGCGGCAGTGGCAGCA	c.(850-870)GCAGCAGCGGCAGTGGCAGCAdel	p.AAAAVAA284del	ZMIZ1_uc001kag.2_In_Frame_Del_p.AAAAVAA160del|ZMIZ1_uc001kah.1_In_Frame_Del_p.AAAAVAA160del	NM_020338	NP_065071	Q9ULJ6	ZMIZ1_HUMAN	retinoic acid induced 17	284_290	Ala-rich.				transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			ovary(2)|breast(1)|skin(1)	4	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			ggcagccgctgcagcagcggcagtggcagcagcagcagcCA	0.511		NaN											NaN	NaN	NaN	NaN	NaN	48	82	---	---							
PAK6	56924	broad.mit.edu	37	15	40566413	40566424	+	In_Frame_Del	DEL	CCCCAGTGCAAG	CCCCAGTGCAAG	-	rs74468066		TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:40566413_40566424delCCCCAGTGCAAG	uc010bbl.2	+	10	2254_2265	c.1814_1825delCCCCAGTGCAAG	c.(1813-1827)TCCCCAGTGCAAGCC>TCC	p.PVQA606del	PAK6_uc010bbm.2_In_Frame_Del_p.PVQA606del|PAK6_uc001zky.3_Intron|PAK6_uc010bbn.2_In_Frame_Del_p.PVQA606del|PAK6_uc001zlb.2_In_Frame_Del_p.PVQA606del	NM_001128628	NP_001122100	Q9NQU5	PAK6_HUMAN	p21-activated kinase 6	606_609	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(5)|large_intestine(1)|ovary(1)|skin(1)	8		all_cancers(109;1.13e-18)|all_epithelial(112;1.62e-15)|Lung NSC(122;5.67e-11)|all_lung(180;1.41e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0823)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.51e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0544)		TTCAGTGACTCCCCAGTGCAAGCCATGAAGAG	0.571		NaN									OREG0023057	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	NaN	NaN	NaN	NaN	NaN	40	87	---	---							
ANKRD11	29123	broad.mit.edu	37	16	89349651	89349651	+	Frame_Shift_Del	DEL	G	G	-			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:89349651delG	uc002fmx.1	-	9	3760	c.3299delC	c.(3298-3300)TCTfs	p.S1100fs	ANKRD11_uc002fmy.1_Frame_Shift_Del_p.S1100fs|ANKRD11_uc002fnc.1_Frame_Shift_Del_p.S1100fs|ANKRD11_uc002fnb.1_Frame_Shift_Del_p.S1057fs	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1100	Lys-rich.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		TTTTTTTTCAGAGAAGTCTTC	0.463		NaN											NaN	NaN	NaN	NaN	NaN	22	39	---	---							
C17orf85	55421	broad.mit.edu	37	17	3721809	3721811	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:3721809_3721811delTCC	uc010ckl.1	-	10	1079_1081	c.1056_1058delGGA	c.(1054-1059)GAGGAA>GAA	p.352_353EE>E	C17orf85_uc002fwr.2_In_Frame_Del_p.62_63EE>E|C17orf85_uc002fwq.2_In_Frame_Del_p.72_73EE>E	NM_001114118	NP_001107590	Q53F19	CQ085_HUMAN	ELG protein isoform a	352_353	Glu-rich.						nucleotide binding			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (3;0.0725)		ctcttcctcttcctcctcctcct	0.379		NaN											NaN	NaN	NaN	NaN	NaN	9	169	---	---							
WRAP53	55135	broad.mit.edu	37	17	7606722	7606722	+	Frame_Shift_Del	DEL	C	C	-	rs7640	byFrequency	TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:7606722delC	uc010vuh.1	+	11	1720	c.1565delC	c.(1564-1566)GCGfs	p.A522fs	WRAP53_uc010vui.1_Frame_Shift_Del_p.A522fs|WRAP53_uc002gip.2_Frame_Shift_Del_p.A522fs|WRAP53_uc002gir.2_Frame_Shift_Del_p.A522fs|WRAP53_uc002giq.2_RNA|WRAP53_uc010cnl.2_Frame_Shift_Del_p.A489fs|EFNB3_uc002gis.2_5'Flank	NM_001143990	NP_001137462	Q9BUR4	WAP53_HUMAN	WD repeat domain 79 isoform 2	522					positive regulation of telomerase activity|telomere formation via telomerase	Cajal body|cytoplasm|telomerase holoenzyme complex	protein binding|RNA binding				0						TGTGGGGGGGCGCCAGACTCC	0.582		NaN											NaN	NaN	NaN	NaN	NaN	7	179	---	---							
ZFP36	7538	broad.mit.edu	37	19	39898948	39898950	+	In_Frame_Del	DEL	CAC	CAC	-			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:39898948_39898950delCAC	uc002olh.1	+	2	648_650	c.590_592delCAC	c.(589-594)TCACCA>TCA	p.P201del	ZFP36_uc010egn.1_In_Frame_Del_p.H73del	NM_003407	NP_003398	P26651	TTP_HUMAN	zinc finger protein 36, C3H type, homolog	201	P-P-P-P-G.				positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	cytosol|nucleus	AU-rich element binding|DNA binding|mRNA binding|protein binding|single-stranded RNA binding|zinc ion binding			pancreas(1)	1	all_cancers(60;6.54e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.53e-06)|Ovarian(47;0.0512)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CGCCGGACCTCACCACCACCACC	0.685		NaN											NaN	NaN	NaN	NaN	NaN	8	725	---	---							
PTPN18	26469	broad.mit.edu	37	2	131129929	131129934	+	In_Frame_Del	DEL	GACGGG	GACGGG	-	rs112040677		TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:131129929_131129934delGACGGG	uc002trc.2	+	13	1214_1219	c.1113_1118delGACGGG	c.(1111-1119)CAGACGGGG>CAG	p.TG378del	PTPN18_uc002trd.2_In_Frame_Del_p.TG357del|PTPN18_uc002trb.2_In_Frame_Del_p.TG271del|PTPN18_uc002tre.2_In_Frame_Del_p.TG29del	NM_014369	NP_055184	Q99952	PTN18_HUMAN	protein tyrosine phosphatase, non-receptor type	378_379				Missing (in Ref. 1; CAA56105).		cytoplasm|nucleus	non-membrane spanning protein tyrosine phosphatase activity			ovary(3)|kidney(1)	4	Colorectal(110;0.1)					gtgggacgcagacggggacggggacg	0.568		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---	---							
COL6A2	1292	broad.mit.edu	37	21	47538527	47538527	+	Splice_Site	DEL	G	G	-			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr21:47538527delG	uc002zia.1	+	13	1199	c.1117_splice	c.e13-1	p.G373_splice	COL6A2_uc002zhy.1_Splice_Site_p.G373_splice|COL6A2_uc002zhz.1_Splice_Site_p.G373_splice|COL6A2_uc002zib.1_Intron	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor						axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		AACCCTTCCAGGGGGACCCTG	0.687		NaN											NaN	NaN	NaN	NaN	NaN	21	25	---	---							
BIK	638	broad.mit.edu	37	22	43525245	43525247	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr22:43525245_43525247delGCT	uc003bdk.2	+	5	477_479	c.417_419delGCT	c.(415-420)GCGCTG>GCG	p.L144del		NM_001197	NP_001188	Q13323	BIK_HUMAN	BCL2-interacting killer	144	Leucine-zipper (Potential).|Helical; (Potential).				apoptosis|induction of apoptosis|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria	endomembrane system|integral to membrane					0		Ovarian(80;0.0694)				tgctgctggcgctgctgctgctg	0.562		NaN											NaN	NaN	NaN	NaN	NaN	9	163	---	---							
ANO10	55129	broad.mit.edu	37	3	43647213	43647213	+	Frame_Shift_Del	DEL	T	T	-			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:43647213delT	uc003cmv.2	-	2	303	c.132delA	c.(130-132)AAAfs	p.K44fs	ANO10_uc011azs.1_Frame_Shift_Del_p.K44fs|ANO10_uc003cmw.2_Frame_Shift_Del_p.K44fs|ANO10_uc010hil.2_Frame_Shift_Del_p.K44fs|ANO10_uc011azt.1_Frame_Shift_Del_p.K44fs	NM_018075	NP_060545	Q9NW15	ANO10_HUMAN	transmembrane protein 16K	44	Cytoplasmic (Potential).				cell death	chloride channel complex	chloride channel activity			ovary(2)	2						CACCTCCATCTTTTTTTTTAG	0.408		NaN											NaN	NaN	NaN	NaN	NaN	8	77	---	---							
H1FOO	132243	broad.mit.edu	37	3	129268112	129268113	+	Frame_Shift_Ins	INS	-	-	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:129268112_129268113insG	uc003emu.2	+	3	652_653	c.647_648insG	c.(646-648)AAGfs	p.K216fs	H1FOO_uc003emv.2_Frame_Shift_Ins_p.K77fs	NM_153833	NP_722575	Q8IZA3	H1FOO_HUMAN	H1 histone family, member O, oocyte-specific	216					meiosis|nucleosome assembly	cytoplasm|nucleosome	DNA binding			skin(1)	1						GAGGCTAGGAAGGTGCCCCCCA	0.649		NaN											NaN	NaN	NaN	NaN	NaN	3	6	---	---							
CRIPAK	285464	broad.mit.edu	37	4	1388441	1388442	+	Frame_Shift_Ins	INS	-	-	CG	rs144787346	byFrequency	TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr4:1388441_1388442insCG	uc003gdf.2	+	1	3102_3103	c.142_143insCG	c.(142-144)ATGfs	p.M48fs		NM_175918	NP_787114	Q8N1N5	CRPAK_HUMAN	cysteine-rich PAK1 inhibitor	48	1.				ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			CTGCTCACACATGCCCATGTGG	0.644		NaN											NaN	NaN	NaN	NaN	NaN	9	1049	---	---							
ANP32C	23520	broad.mit.edu	37	4	165118286	165118288	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr4:165118286_165118288delTCC	uc011cjk.1	-	1	576_578	c.576_578delGGA	c.(574-579)GAGGAA>GAA	p.192_193EE>E	MARCH1_uc003iqs.1_Intron	NM_012403	NP_036535	O43423	AN32C_HUMAN	acidic nuclear phosphoprotein 32C	192_193	Asp/Glu-rich (highly acidic).										0	all_hematologic(180;0.203)	Prostate(90;0.0138)|Melanoma(52;0.18)|all_neural(102;0.223)		KIRC - Kidney renal clear cell carcinoma(143;0.242)		ctcttcaccttcctcctcctcct	0.192		NaN											NaN	NaN	NaN	NaN	NaN	5	11	---	---							
PCDHB4	56131	broad.mit.edu	37	5	140502486	140502487	+	Frame_Shift_Ins	INS	-	-	A			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr5:140502486_140502487insA	uc003lip.1	+	1	906_907	c.906_907insA	c.(904-909)TTGAAAfs	p.L302fs		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	302_303	Cadherin 3.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAATACTGTTGAAAAAAAAATT	0.366		NaN											NaN	NaN	NaN	NaN	NaN	8	138	---	---							
WBSCR28	135886	broad.mit.edu	37	7	73280067	73280068	+	Frame_Shift_Ins	INS	-	-	C			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:73280067_73280068insC	uc003tzk.2	+	3	698_699	c.662_663insC	c.(661-663)CACfs	p.H221fs	RFC2_uc011kfa.1_Intron|WBSCR28_uc003tzl.2_Frame_Shift_Ins_p.H120fs	NM_182504	NP_872310	Q6UE05	WBS28_HUMAN	hypothetical protein LOC135886	221						integral to membrane				breast(1)	1		Lung NSC(55;0.159)				GCCTTTGAGCACACGACCCAGC	0.629		NaN											NaN	NaN	NaN	NaN	NaN	7	511	---	---							
PKHD1L1	93035	broad.mit.edu	37	8	110455173	110455174	+	Splice_Site	INS	-	-	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr8:110455173_110455174insG	uc003yne.2	+	36	4498	c.4394_splice	c.e36-1	p.G1465_splice		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor						immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ATTTTATGGCAGGTTCATTTTC	0.322		NaN								HNSCC(38;0.096)			NaN	NaN	NaN	NaN	NaN	8	116	---	---							
SLC45A4	57210	broad.mit.edu	37	8	142228490	142228492	+	In_Frame_Del	DEL	GCC	GCC	-			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr8:142228490_142228492delGCC	uc003ywd.1	-	4	1402_1404	c.1094_1096delGGC	c.(1093-1098)CGGCAC>CAC	p.R365del	SLC45A4_uc003ywc.1_In_Frame_Del_p.R365del|SLC45A4_uc010meq.1_In_Frame_Del_p.R363del	NM_001080431	NP_001073900	Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	416					transport	integral to membrane				ovary(2)	2	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			CGGAACGCGTGCCGCCGCCGCCG	0.675		NaN											NaN	NaN	NaN	NaN	NaN	7	265	---	---							
FOXD4	2298	broad.mit.edu	37	9	117406	117407	+	Frame_Shift_Ins	INS	-	-	G			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:117406_117407insG	uc003zfz.2	-	1	1011_1012	c.713_714insC	c.(712-714)CCGfs	p.P238fs		NM_207305	NP_997188	Q12950	FOXD4_HUMAN	forkhead box D4	238	Pro-rich.				axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1	all_lung(41;0.218)	all_cancers(5;0.0395)|Acute lymphoblastic leukemia(5;1.91e-07)|all_hematologic(5;1.95e-06)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		CTGGCTGCGGCGGGGCAGGGGC	0.743		NaN											NaN	NaN	NaN	NaN	NaN	7	213	---	---