Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
SAMD11	148398	broad.mit.edu	37	1	879384	879384	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:879384G>A	uc001abw.1	+	14	1977	c.1897G>A	c.(1897-1899)GGC>AGC	p.G633S	SAMD11_uc001abx.1_Missense_Mutation_p.G496S	NM_152486	NP_689699	Q96NU1	SAM11_HUMAN	sterile alpha motif domain containing 11	633						nucleus					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.74e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.93e-23)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.000472)|Kidney(185;0.0023)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.199)		GCGAGAACTCGGCACAGGAGA	0.682		NaN											0	0	0	0.01441	0	53	45									
TPRG1L	127262	broad.mit.edu	37	1	3544178	3544178	+	Silent	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:3544178G>A	uc001akm.2	+	4	666	c.585G>A	c.(583-585)CCG>CCA	p.P195P	TPRG1L_uc009vlj.2_Silent_p.P136P	NM_182752	NP_877429	Q5T0D9	TPRGL_HUMAN	tumor protein p63 regulated 1-like	195						cell junction|synaptic vesicle					0	all_cancers(77;0.0119)|all_epithelial(69;0.00481)|Ovarian(185;0.0634)|Lung NSC(156;0.162)|all_lung(157;0.172)	all_epithelial(116;7.37e-22)|all_lung(118;8.23e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.41e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.83e-22)|GBM - Glioblastoma multiforme(42;4.77e-14)|Colorectal(212;1.12e-05)|COAD - Colon adenocarcinoma(227;5.61e-05)|Kidney(185;0.000351)|BRCA - Breast invasive adenocarcinoma(365;0.000688)|KIRC - Kidney renal clear cell carcinoma(229;0.00553)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.201)		CAGAACACCCGATGGCTGGCG	0.532		NaN											0	0	0	0.007413	0	17	161									
CHD5	26038	broad.mit.edu	37	1	6196893	6196893	+	Silent	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:6196893G>C	uc001amb.1	-	16	2569	c.2469C>G	c.(2467-2469)CTC>CTG	p.L823L	CHD5_uc001ama.1_RNA|CHD5_uc001amc.1_RNA|CHD5_uc009vlx.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	823	Helicase ATP-binding.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		CATAGGAGGTGAGCAGCACGT	0.567		NaN											0	0	0	0.004289	0	28	41									
PRDM2	7799	broad.mit.edu	37	1	14075874	14075874	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:14075874G>A	uc001avi.2	+	6	1259	c.403G>A	c.(403-405)GAG>AAG	p.E135K	PRDM2_uc001avg.2_Missense_Mutation_p.E135K|PRDM2_uc001avh.2_Missense_Mutation_p.E135K|PRDM2_uc001avj.2_RNA|PRDM2_uc009vod.1_5'UTR|PRDM2_uc001avk.2_5'UTR|PRDM2_uc009voe.2_RNA|PRDM2_uc009vof.2_RNA	NM_012231	NP_036363	Q13029	PRDM2_HUMAN	retinoblastoma protein-binding zinc finger	135	SET.					Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		GCCGGGCGAGGAGCTCCTGGT	0.537		NaN											0	0	0	0.000602	0	5	37									
UBR4	23352	broad.mit.edu	37	1	19528304	19528304	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:19528304G>A	uc001bbi.2	-	2	186	c.182C>T	c.(181-183)TCA>TTA	p.S61L		NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	61					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		CAGGATTTCTGATTCACTGTA	0.219		NaN											0	0	0	0.001984	0	6	48									
PQLC2	54896	broad.mit.edu	37	1	19653762	19653762	+	Silent	SNP	C	C	T	rs139194294	byFrequency	TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:19653762C>T	uc001bby.2	+	8	1012	c.660C>T	c.(658-660)TTC>TTT	p.F220F	PQLC2_uc001bbz.2_Silent_p.F155F|PQLC2_uc001bca.2_Silent_p.F220F|PQLC2_uc001bcb.2_Silent_p.F109F|PQLC2_uc001bcc.2_Silent_p.F109F	NM_017765	NP_060235	Q6ZP29	PQLC2_HUMAN	PQ loop repeat containing 2 isoform 1	220	PQ-loop 2.|Helical; (Potential).					integral to membrane					0		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;1.89e-05)|Kidney(64;0.000177)|GBM - Glioblastoma multiforme(114;0.00124)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		ACTCTCTGTTCGCGCTGGTGA	0.552		NaN											0	0	0	0.01441	0	51	69									
HNRNPR	10236	broad.mit.edu	37	1	23648144	23648144	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:23648144C>T	uc001bgr.3	-	7	847	c.688G>A	c.(688-690)GAA>AAA	p.E230K	HNRNPR_uc001bgp.3_Missense_Mutation_p.E230K|HNRNPR_uc009vqk.2_Missense_Mutation_p.E129K|HNRNPR_uc001bgs.3_Missense_Mutation_p.E129K|HNRNPR_uc010odw.1_Missense_Mutation_p.E192K|HNRNPR_uc010odx.1_Missense_Mutation_p.E70K|HNRNPR_uc009vql.2_Missense_Mutation_p.E91K	NM_005826	NP_005817	O43390	HNRPR_HUMAN	heterogeneous nuclear ribonucleoprotein R	230	RRM 1.					catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00394)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;6.83e-27)|Colorectal(126;6.01e-08)|COAD - Colon adenocarcinoma(152;3.32e-06)|GBM - Glioblastoma multiforme(114;6.69e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00357)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0875)|LUSC - Lung squamous cell carcinoma(448;0.19)		GGGCGAATTTCATAGCTGTCA	0.383		NaN											0	0	0	0.01441	0	78	92									
ASAP3	55616	broad.mit.edu	37	1	23767922	23767922	+	Silent	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:23767922G>A	uc001bha.2	-	9	916	c.792C>T	c.(790-792)CTC>CTT	p.L264L	ASAP3_uc010odz.1_Silent_p.L133L|ASAP3_uc010oea.1_Silent_p.L255L|ASAP3_uc001bhb.2_5'Flank	NM_017707	NP_060177	Q8TDY4	ASAP3_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	264	Potential.				regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3						GGGAGTCCCGGAGCTGGGTCA	0.597		NaN											0	0	0	0.003163	0	11	22									
CSMD2	114784	broad.mit.edu	37	1	34042907	34042907	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:34042907G>A	uc001bxn.1	-	50	7600	c.7571C>T	c.(7570-7572)CCT>CTT	p.P2524L	CSMD2_uc001bxm.1_Missense_Mutation_p.P2522L	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2524	Sushi 14.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TTGACAGAGAGGGATGGCTTC	0.577		NaN											0	0	0	0.01441	0	47	61									
EIF2C3	192669	broad.mit.edu	37	1	36520571	36520571	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:36520571C>T	uc001bzp.2	+	18	2555	c.2299C>T	c.(2299-2301)CAT>TAT	p.H767Y	EIF2C3_uc001bzq.2_Missense_Mutation_p.H533Y	NM_024852	NP_079128	Q9H9G7	AGO3_HUMAN	eukaryotic translation initiation factor 2C, 3	767	Piwi.				mRNA catabolic process|negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TTCACACTATCATGTTTTATG	0.348		NaN											0	0	0	0.01441	0	46	84									
EIF2C3	192669	broad.mit.edu	37	1	36520721	36520721	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:36520721C>T	uc001bzp.2	+	18	2705	c.2449C>T	c.(2449-2451)CAT>TAT	p.H817Y	EIF2C3_uc001bzq.2_Missense_Mutation_p.H583Y	NM_024852	NP_079128	Q9H9G7	AGO3_HUMAN	eukaryotic translation initiation factor 2C, 3	817	Piwi.				mRNA catabolic process|negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AGCCAGATATCATCTTGTGGA	0.423		NaN											0	0	0	0.000602	0	3	11									
MANEAL	149175	broad.mit.edu	37	1	38265848	38265848	+	Silent	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:38265848C>T	uc001cby.2	+	4	1428	c.1347C>T	c.(1345-1347)ATC>ATT	p.I449I	MANEAL_uc001cbx.2_3'UTR|MANEAL_uc001cbz.2_Silent_p.I227I	NM_001113482	NP_001106954	Q5VSG8	MANEL_HUMAN	mannosidase, endo-alpha-like isoform 3	449	Lumenal (Potential).					Golgi membrane|integral to membrane	hydrolase activity				0	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				AGCACTTCATCAAAGAGAAGG	0.582		NaN											0	0	0	0.007835	0	35	59									
ERMAP	114625	broad.mit.edu	37	1	43296669	43296669	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:43296669G>A	uc001cic.1	+	4	586	c.316G>A	c.(316-318)GAG>AAG	p.E106K	ERMAP_uc010ojw.1_Missense_Mutation_p.E167K|ERMAP_uc001cid.1_Intron|ERMAP_uc001cie.1_Missense_Mutation_p.E106K|ERMAP_uc001cif.1_Missense_Mutation_p.E16K	NM_001017922	NP_001017922	Q96PL5	ERMAP_HUMAN	erythroblast membrane-associated protein	106	Ig-like V-type.|Extracellular (Potential).		DAQEGSVTLQI -> CPRGKCHSADP (in Sc-3 allele).			integral to membrane|plasma membrane				ovary(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				AGATGCCCAAGAGGGAAGTGT	0.532		NaN											0	0	0	0.001984	0	5	67									
NASP	4678	broad.mit.edu	37	1	46080036	46080036	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:46080036C>A	uc001coi.1	+	9	1766	c.1664C>A	c.(1663-1665)TCT>TAT	p.S555Y	NASP_uc001coh.1_Missense_Mutation_p.S557Y|NASP_uc001coj.1_Missense_Mutation_p.S216Y|NASP_uc010olr.1_Missense_Mutation_p.S491Y|NASP_uc001col.1_Missense_Mutation_p.S63Y	NM_002482	NP_002473	P49321	NASP_HUMAN	nuclear autoantigenic sperm protein isoform 2	555	TPR 2.|Glu-rich (acidic).				blastocyst development|cell cycle|cell proliferation|DNA replication|histone exchange|protein transport	cytoplasm|nucleus	Hsp90 protein binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.211)					AGTGTTGAATCTGGTAATGCA	0.378		NaN											1	0	9.65021e-13	0.010818	1.02374e-12	25	42									
PRKACB	5567	broad.mit.edu	37	1	84668421	84668421	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:84668421C>T	uc001djj.2	+	8	962	c.698C>T	c.(697-699)GCA>GTA	p.A233V	PRKACB_uc001djl.2_Missense_Mutation_p.A280V|PRKACB_uc010ort.1_Missense_Mutation_p.A240V|PRKACB_uc001djn.2_Missense_Mutation_p.A237V|PRKACB_uc010oru.1_Missense_Mutation_p.A221V|PRKACB_uc001djp.2_Missense_Mutation_p.A239V|PRKACB_uc001djq.2_Missense_Mutation_p.A203V|PRKACB_uc010orv.1_Missense_Mutation_p.A220V|PRKACB_uc001dji.2_Missense_Mutation_p.A233V|PRKACB_uc001djk.2_Missense_Mutation_p.A280V|PRKACB_uc009wcf.1_Missense_Mutation_p.A239V	NM_002731	NP_002722	P22694	KAPCB_HUMAN	cAMP-dependent protein kinase catalytic subunit	233	Protein kinase.			A -> V (in Ref. 3; CAI56774).	activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein signaling, coupled to cAMP nucleotide second messenger|gluconeogenesis|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|regulation of insulin secretion|synaptic transmission|transmembrane transport|triglyceride catabolic process|water transport	cAMP-dependent protein kinase complex|centrosome|cytosol|nucleoplasm|plasma membrane	ATP binding|cAMP-dependent protein kinase activity|magnesium ion binding|protein binding			lung(2)|ovary(1)	3				all cancers(265;0.00536)|Epithelial(280;0.0161)|OV - Ovarian serous cystadenocarcinoma(397;0.141)		TATGAAATGGCAGCTGGCTAT	0.373		NaN											0	0	0	0.007413	0	15	193									
CLCA2	9635	broad.mit.edu	37	1	86921014	86921014	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:86921014C>T	uc001dlr.3	+	14	2798	c.2636C>T	c.(2635-2637)TCT>TTT	p.S879F		NM_006536	NP_006527	Q9UQC9	CLCA2_HUMAN	chloride channel accessory 2 precursor	879	Extracellular (Potential).				cell adhesion	basal plasma membrane|cell junction|extracellular region|integral to plasma membrane	chloride channel activity			ovary(1)|breast(1)|skin(1)	3		Lung NSC(277;0.238)		all cancers(265;0.0233)|Epithelial(280;0.0452)		TCTGCTGTATCTAACATTGCC	0.423		NaN											0	0	0	0.007291	0	21	275									
PTBP2	58155	broad.mit.edu	37	1	97278831	97278831	+	Splice_Site	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:97278831G>C	uc001drq.2	+	14	1713	c.1467_splice	c.e14-1	p.Q489_splice	PTBP2_uc001drn.2_Missense_Mutation_p.R495T|PTBP2_uc001dro.2_Missense_Mutation_p.R490T|PTBP2_uc010otz.1_Missense_Mutation_p.R506T|PTBP2_uc001drp.2_RNA|PTBP2_uc009wdw.2_Missense_Mutation_p.R438T|PTBP2_uc001drr.2_Splice_Site_p.Q494_splice|PTBP2_uc010oua.1_Missense_Mutation_p.R498T|PTBP2_uc001dru.2_Splice_Site|PTBP2_uc001drs.1_Missense_Mutation_p.R109T|PTBP2_uc001drt.2_Splice_Site_p.Q108_splice	NM_021190	NP_067013	Q9UKA9	PTBP2_HUMAN	polypyrimidine tract binding protein 2								nucleotide binding				0		all_epithelial(167;2.95e-05)|all_lung(203;0.000396)|Lung NSC(277;0.00171)		all cancers(265;0.0582)|Epithelial(280;0.0716)|Colorectal(170;0.0879)|KIRC - Kidney renal clear cell carcinoma(1967;0.202)		TGTTTCAGAAGAGATCACAAA	0.323		NaN											0	0	0	0.009096	0	3	53									
STXBP3	6814	broad.mit.edu	37	1	109339242	109339242	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:109339242G>T	uc001dvy.2	+	15	1325	c.1250G>T	c.(1249-1251)GGA>GTA	p.G417V	STXBP3_uc001dvz.2_RNA	NM_007269	NP_009200	O00186	STXB3_HUMAN	syntaxin binding protein 3	417					negative regulation of calcium ion-dependent exocytosis|neutrophil degranulation|platelet aggregation|protein transport|vesicle docking involved in exocytosis	cytosol|nucleus|platelet alpha granule|specific granule|tertiary granule	syntaxin-2 binding			ovary(3)|central_nervous_system(1)	4		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0386)|Lung(183;0.104)|COAD - Colon adenocarcinoma(174;0.137)|Epithelial(280;0.231)		CCTATTTAAGGAACTACGGAA	0.338		NaN											1	0	1.68575e-08	0.007291	1.75581e-08	26	27									
AMIGO1	57463	broad.mit.edu	37	1	110050083	110050083	+	Silent	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:110050083C>T	uc001dxx.3	-	2	1834	c.1452G>A	c.(1450-1452)TCG>TCA	p.S484S		NM_020703	NP_065754	Q86WK6	AMGO1_HUMAN	AMIGO protein precursor	484	Cytoplasmic (Potential).				axonal fasciculation|heterophilic cell-cell adhesion|homophilic cell adhesion|myelination|positive regulation of axonogenesis	axon|integral to membrane				ovary(1)|breast(1)	2		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Colorectal(144;0.0129)|Lung(183;0.0182)|Epithelial(280;0.046)|all cancers(265;0.0492)|READ - Rectum adenocarcinoma(129;0.0689)|LUSC - Lung squamous cell carcinoma(189;0.227)		CAGAGAAGACCGAGCTGACTG	0.582		NaN											0	0	0	0.008871	0	16	214									
DDX20	11218	broad.mit.edu	37	1	112298569	112298569	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:112298569C>T	uc001ebs.2	+	1	380	c.23C>T	c.(22-24)TCG>TTG	p.S8L	C1orf183_uc001ebp.1_5'Flank|uc001ebr.2_5'Flank|DDX20_uc010owf.1_5'UTR	NM_007204	NP_009135	Q9UHI6	DDX20_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	8					assembly of spliceosomal tri-snRNP|ncRNA metabolic process	Cajal body|cytoskeleton|cytosol|spliceosomal complex	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding			lung(1)|kidney(1)	2		all_cancers(81;1.06e-05)|all_epithelial(167;7.36e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.15e-05)		Lung(183;0.0234)|Colorectal(144;0.0282)|all cancers(265;0.0614)|Epithelial(280;0.0999)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTTGAAGCCTCGGGAGCCTTA	0.632		NaN											0	0	0	0.004007	0	13	29									
TTF2	8458	broad.mit.edu	37	1	117633952	117633952	+	Nonsense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:117633952C>G	uc001egy.2	+	16	2611	c.2591C>G	c.(2590-2592)TCA>TGA	p.S864*		NM_003594	NP_003585	Q9UNY4	TTF2_HUMAN	transcription termination factor, RNA polymerase	864					mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|termination of RNA polymerase II transcription	cytoplasm|spliceosomal complex|transcription elongation factor complex	ATP binding|ATP-dependent helicase activity|DNA binding|DNA-dependent ATPase activity|protein binding|zinc ion binding			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;4.23e-06)|all_epithelial(167;3.65e-07)|all_lung(203;2.81e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0553)|Colorectal(144;0.179)|LUSC - Lung squamous cell carcinoma(189;0.19)		TGAGGCAGGTCAGCTCTGCAA	0.393		NaN											0	0	0	0.013114	0	42	77									
NBPF9	400818	broad.mit.edu	37	1	144220816	144220816	+	Missense_Mutation	SNP	A	A	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:144220816A>G	uc010oxr.1	+	19	2193	c.2189A>G	c.(2188-2190)GAG>GGG	p.E730G	NBPF9_uc010oxn.1_Missense_Mutation_p.E601G|NBPF9_uc010oxo.1_Intron|NBPF9_uc010oxt.1_Missense_Mutation_p.E518G|NBPF9_uc001ekg.1_Missense_Mutation_p.E30G|NBPF9_uc001ekk.1_Missense_Mutation_p.E274G|NBPF10_uc009wir.2_Intron|NBPF9_uc010oyd.1_Missense_Mutation_p.E30G|uc010oxz.1_Missense_Mutation_p.E518G	NM_001037675	NP_001032764	Q3BBV1	NBPFK_HUMAN	hypothetical protein LOC400818	703	NBPF 5.					cytoplasm					0						GATGAGAAAGAGCCTGAAGTC	0.483		NaN											0	0	0	0.001984	0	5	278									
NBPF10	100132406	broad.mit.edu	37	1	145360624	145360624	+	Silent	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:145360624G>A	uc001end.3	+	76	9509	c.9474G>A	c.(9472-9474)TCG>TCA	p.S3158S	NBPF9_uc010oye.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Intron|NBPF10_uc010oyk.1_Intron|NBPF10_uc010oyl.1_Intron|NBPF10_uc001enc.2_Intron|NBPF10_uc010oyq.1_Intron|NBPF10_uc010oyr.1_Silent_p.S456S	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	3083											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		GATGTTATTCGACTCCTTCAG	0.478		NaN											0	0	0	0.004482	0	8	24									
HRNR	388697	broad.mit.edu	37	1	152190860	152190860	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:152190860G>A	uc001ezt.1	-	3	3321	c.3245C>T	c.(3244-3246)ACA>ATA	p.T1082I		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	1082	12.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGTCCTGATGTAGAACCGTG	0.552		NaN											0	0	0	0.01441	0	197	517									
LCE1D	353134	broad.mit.edu	37	1	152770489	152770489	+	Silent	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:152770489G>A	uc009wnp.2	+	2	262	c.219G>A	c.(217-219)CTG>CTA	p.L73L		NM_178352	NP_848129	Q5T752	LCE1D_HUMAN	late cornified envelope 1D	73	Cys-rich.				cellular response to calcium ion|keratinization	cornified envelope|perinuclear region of cytoplasm					0	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCTGCTGCCTGAGCCACCACA	0.711		NaN											0	0	0	0.00308	0	8	22									
LCE1D	353134	broad.mit.edu	37	1	152770614	152770614	+	Silent	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:152770614G>A	uc009wnp.2	+	2	387	c.344G>A	c.(343-345)TGA>TAA	p.*115*		NM_178352	NP_848129	Q5T752	LCE1D_HUMAN	late cornified envelope 1D	115					cellular response to calcium ion|keratinization	cornified envelope|perinuclear region of cytoplasm					0	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGCTGCTGCTGAAGTGGACCT	0.602		NaN											0	0	0	0.01441	0	39	2									
INTS3	65123	broad.mit.edu	37	1	153745426	153745426	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:153745426G>A	uc009wom.2	+	30	3141	c.2920G>A	c.(2920-2922)GAG>AAG	p.E974K	INTS3_uc001fct.2_Missense_Mutation_p.E974K|INTS3_uc001fcu.2_Missense_Mutation_p.E666K|INTS3_uc001fcv.2_Missense_Mutation_p.E768K|INTS3_uc010peb.1_Missense_Mutation_p.E834K|INTS3_uc001fcw.2_Missense_Mutation_p.E487K|INTS3_uc010pec.1_Missense_Mutation_p.E487K|INTS3_uc001fcy.2_Missense_Mutation_p.E337K|INTS3_uc001fcx.2_Missense_Mutation_p.E271K	NM_023015	NP_075391	Q68E01	INT3_HUMAN	integrator complex subunit 3	975					DNA repair|G2/M transition checkpoint|response to ionizing radiation|snRNA processing	integrator complex|SOSS complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CTCCCTGGCGGAGGAATATGA	0.572		NaN											0	0	0	0.006122	0	17	138									
ADAR	103	broad.mit.edu	37	1	154557296	154557296	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:154557296G>C	uc001ffh.2	-	15	3867	c.3667C>G	c.(3667-3669)CTC>GTC	p.L1223V	ADAR_uc001ffj.2_Missense_Mutation_p.L1178V|ADAR_uc001ffi.2_Missense_Mutation_p.L1197V|ADAR_uc001ffk.2_Missense_Mutation_p.L928V	NM_001111	NP_001102	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific isoform a	1223					adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		ACTGGGCAGAGATAAAAGTTC	0.483		NaN											0	0	0	0.01441	0	71	190									
ADAR	103	broad.mit.edu	37	1	154571024	154571024	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:154571024G>A	uc001ffh.2	-	3	1839	c.1639C>T	c.(1639-1641)CCC>TCC	p.P547S	ADAR_uc001ffj.2_Missense_Mutation_p.P547S|ADAR_uc001ffi.2_Missense_Mutation_p.P547S|ADAR_uc001ffk.2_Missense_Mutation_p.P252S	NM_001111	NP_001102	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific isoform a	547	DRBM 1.				adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		TCAGCTGGGGGAAACTCTCGG	0.473		NaN											0	0	0	0.00245	0	12	167									
KIRREL	55243	broad.mit.edu	37	1	158061194	158061194	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:158061194G>A	uc001frn.3	+	11	1723	c.1319G>A	c.(1318-1320)CGC>CAC	p.R440H	KIRREL_uc010pib.1_Missense_Mutation_p.R340H|KIRREL_uc009wsq.2_Missense_Mutation_p.R276H|KIRREL_uc001fro.3_Missense_Mutation_p.R254H	NM_018240	NP_060710	Q96J84	KIRR1_HUMAN	kin of IRRE like precursor	440	Ig-like C2-type 5.|Extracellular (Potential).					integral to membrane				ovary(1)	1	all_hematologic(112;0.0378)					ACCCTGGAACGCTATACAGTG	0.567		NaN											0	0	0	0.006999	0	41	120									
OR6Y1	391112	broad.mit.edu	37	1	158517192	158517192	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:158517192G>A	uc010pil.1	-	1	704	c.704C>T	c.(703-705)TCT>TTT	p.S235F		NM_001005189	NP_001005189	Q8NGX8	OR6Y1_HUMAN	olfactory receptor, family 6, subfamily Y,	235	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					GCCCTGAGCAGAAGGGATCCT	0.522		NaN											0	0	0	0.01441	0	55	95									
OR10J1	26476	broad.mit.edu	37	1	159409658	159409658	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:159409658C>T	uc010piv.1	+	1	110	c.110C>T	c.(109-111)ACC>ATC	p.T37I	uc001fts.3_Intron	NM_012351	NP_036483	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J,	37	Helical; Name=1; (Potential).				sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0429)					CAGCAGATCACCCTTTTTGGC	0.418		NaN											0	0	0	0.01441	0	177	124									
IGSF9	57549	broad.mit.edu	37	1	159897219	159897219	+	Silent	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:159897219G>A	uc001fur.2	-	21	3654	c.3456C>T	c.(3454-3456)TTC>TTT	p.F1152F	IGSF9_uc001fuq.2_Silent_p.F1136F|CCDC19_uc001ful.2_5'Flank|TAGLN2_uc001fun.1_5'Flank|TAGLN2_uc001fuo.1_5'Flank|TAGLN2_uc010piy.1_5'Flank|IGSF9_uc001fup.2_Silent_p.F298F	NM_001135050	NP_001128522	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9 isoform a	1152	Cytoplasmic (Potential).					cell junction|integral to membrane|synapse				ovary(2)|central_nervous_system(2)|large_intestine(1)	5	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			GGCGGCGGCGGAAGGCCAGGA	0.632		NaN											0	0	0	0.01441	0	46	106									
BLZF1	8548	broad.mit.edu	37	1	169345923	169345923	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:169345923G>C	uc001gfx.1	+	3	611	c.174G>C	c.(172-174)GAG>GAC	p.E58D	BLZF1_uc001gfw.2_Missense_Mutation_p.E58D|BLZF1_uc001gfy.2_Missense_Mutation_p.E58D|BLZF1_uc009wvp.1_Missense_Mutation_p.E35D	NM_003666	NP_003657	Q9H2G9	GO45_HUMAN	basic leucine zipper nuclear factor 1	58					cell proliferation|Golgi organization|Golgi to plasma membrane protein transport|regulation of cell growth|regulation of transcription from RNA polymerase II promoter	Golgi lumen|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding			skin(1)	1	all_hematologic(923;0.208)					TTCCATCAGAGAGCCCAGGAG	0.413		NaN											0	0	0	0.014323	0	20	83									
BLZF1	8548	broad.mit.edu	37	1	169346158	169346158	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:169346158G>C	uc001gfx.1	+	3	846	c.409G>C	c.(409-411)GAA>CAA	p.E137Q	BLZF1_uc001gfw.2_Missense_Mutation_p.E137Q|BLZF1_uc001gfy.2_Missense_Mutation_p.E137Q|BLZF1_uc009wvp.1_Missense_Mutation_p.E114Q	NM_003666	NP_003657	Q9H2G9	GO45_HUMAN	basic leucine zipper nuclear factor 1	137	Potential.				cell proliferation|Golgi organization|Golgi to plasma membrane protein transport|regulation of cell growth|regulation of transcription from RNA polymerase II promoter	Golgi lumen|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding			skin(1)	1	all_hematologic(923;0.208)					CAAGAATTCTGAAAGAAGGTT	0.383		NaN											0	0	0	0.010818	0	25	49									
SCYL3	57147	broad.mit.edu	37	1	169825055	169825055	+	Silent	SNP	C	C	T	rs75739679	byFrequency	TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:169825055C>T	uc001ggs.2	-	12	1554	c.1356G>A	c.(1354-1356)TCG>TCA	p.S452S	SCYL3_uc010plw.1_Intron|SCYL3_uc001ggt.2_Intron|SCYL3_uc001ggu.2_Intron	NM_181093	NP_851607	Q8IZE3	PACE1_HUMAN	SCY1-like 3 isoform 2	452					cell migration	Golgi apparatus|lamellipodium	ATP binding|protein binding|protein kinase activity			ovary(1)|skin(1)	2	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CCAAGATTGGCGAGATCTGAC	0.428		NaN											0	0	0	0.000602	0	4	133									
TPR	7175	broad.mit.edu	37	1	186326652	186326652	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:186326652G>A	uc001grv.2	-	14	1898	c.1601C>T	c.(1600-1602)TCA>TTA	p.S534L	TPR_uc010pop.1_Missense_Mutation_p.S610L	NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	534	Potential.				carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		TAGATGCTGTGATATTACCTC	0.403		NaN	T	NTRK1	papillary thyroid								0	0	0	0.013114	0	44	83									
CFH	3075	broad.mit.edu	37	1	196643008	196643008	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:196643008G>C	uc001gtj.3	+	3	506	c.266G>C	c.(265-267)GGA>GCA	p.G89A	CFH_uc001gti.3_Missense_Mutation_p.G89A|CFH_uc009wyw.2_Missense_Mutation_p.G89A|CFH_uc009wyx.2_Missense_Mutation_p.G89A	NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	89	Sushi 2.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						GGACATCCTGGAGATACTCCT	0.363		NaN											0	0	0	0.004007	0	13	199									
LAD1	3898	broad.mit.edu	37	1	201351425	201351425	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:201351425C>G	uc001gwm.2	-	9	1738	c.1503G>C	c.(1501-1503)GAG>GAC	p.E501D		NM_005558	NP_005549	O00515	LAD1_HUMAN	ladinin 1	501						basement membrane	structural molecule activity				0						ACTGAGTCCTCTCGGTTGCAG	0.607		NaN											0	0	0	0.01441	0	107	59									
ATP2B4	493	broad.mit.edu	37	1	203676348	203676348	+	Silent	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:203676348G>A	uc001gzw.2	+	9	2195	c.1311G>A	c.(1309-1311)GTG>GTA	p.V437V	ATP2B4_uc001gzv.2_Silent_p.V437V|ATP2B4_uc009xaq.2_Silent_p.V437V	NM_001684	NP_001675	P23634	AT2B4_HUMAN	plasma membrane calcium ATPase 4 isoform 4b	437	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|skin(1)	3	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CCTACTCTGTGAAGGTGAGAC	0.468		NaN											0	0	0	0.001984	0	7	115									
PIGR	5284	broad.mit.edu	37	1	207112588	207112588	+	Silent	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:207112588C>T	uc001hez.2	-	3	448	c.264G>A	c.(262-264)CCG>CCA	p.P88P	PIGR_uc009xbz.2_Silent_p.P88P	NM_002644	NP_002635	P01833	PIGR_HUMAN	polymeric immunoglobulin receptor precursor	88	Ig-like V-type 1.|Extracellular (Potential).					extracellular region|integral to plasma membrane	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3						TGCCGTTCTCCGGGAAGTTGG	0.592		NaN											0	0	0	0.009096	0	4	91									
NSL1	25936	broad.mit.edu	37	1	212911828	212911828	+	Silent	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:212911828C>T	uc001hjn.2	-	6	802	c.768G>A	c.(766-768)CTG>CTA	p.L256L	NSL1_uc001hjm.2_3'UTR|NSL1_uc010pti.1_Silent_p.L215L	NM_015471	NP_056286	Q96IY1	NSL1_HUMAN	NSL1, MIND kinetochore complex component isoform	256					cell division|chromosome segregation|mitotic prometaphase	cytosol|MIS12/MIND type complex|nucleus	protein binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.00597)|all cancers(67;0.00893)|GBM - Glioblastoma multiforme(131;0.0514)|Epithelial(68;0.102)		GCTTTCTTTTCAGTACCATGT	0.398		NaN											0	0	0	0.005443	0	20	176									
EPRS	2058	broad.mit.edu	37	1	220174523	220174523	+	Nonsense_Mutation	SNP	G	G	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:220174523G>T	uc001hly.1	-	17	2408	c.2138C>A	c.(2137-2139)TCA>TAA	p.S713*	EPRS_uc010puf.1_Nonsense_Mutation_p.S464*|EPRS_uc001hlz.1_Nonsense_Mutation_p.S720*|EPRS_uc009xdt.1_Nonsense_Mutation_p.S301*	NM_004446	NP_004437	P07814	SYEP_HUMAN	glutamyl-prolyl tRNA synthetase	713	Glutamyl-tRNA synthetase.				glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)	CTTTGACCCTGATGTTGGCAT	0.373		NaN											1	0	2.81731e-10	0.010818	2.95744e-10	29	65									
NSUN6	221078	broad.mit.edu	37	10	18840786	18840786	+	Nonsense_Mutation	SNP	G	G	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr10:18840786G>T	uc010qcp.1	-	9	1455	c.1037C>A	c.(1036-1038)TCA>TAA	p.S346*		NM_182543	NP_872349	Q8TEA1	NSUN6_HUMAN	NOL1/NOP2/Sun domain family, member 6	346							methyltransferase activity|RNA binding			ovary(2)	2						TGGCTGATATGATGCCACTTC	0.423		NaN											1	0	0.00198382	0.001984	0.00201395	5	155									
ARMC4	55130	broad.mit.edu	37	10	28276464	28276464	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr10:28276464G>C	uc009xky.2	-	3	331	c.233C>G	c.(232-234)ACA>AGA	p.T78R	ARMC4_uc001itz.2_Missense_Mutation_p.T78R	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	78							binding			ovary(4)|skin(2)	6						TGATTTGACTGTTGTTTCACt	0.318		NaN											0	0	0	0.006214	0	8	22									
VCL	7414	broad.mit.edu	37	10	75849105	75849105	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr10:75849105C>T	uc001jwd.2	+	9	1268	c.1174C>T	c.(1174-1176)CAG>TAG	p.Q392*	VCL_uc009xrr.2_Nonsense_Mutation_p.Q141*|VCL_uc010qky.1_Nonsense_Mutation_p.Q299*|VCL_uc001jwe.2_Nonsense_Mutation_p.Q392*|VCL_uc010qkz.1_Intron	NM_014000	NP_054706	P18206	VINC_HUMAN	vinculin isoform meta-VCL	392	N-terminal globular head.|3 X 112 AA tandem repeats.|2.				adherens junction assembly|apical junction assembly|cell-matrix adhesion|cellular component movement|epithelial cell-cell adhesion|lamellipodium assembly|morphogenesis of an epithelium|muscle contraction|negative regulation of cell migration|platelet activation|platelet degranulation|protein localization at cell surface	costamere|cytosol|extracellular region|focal adhesion	actin binding|alpha-catenin binding|beta-catenin binding|beta-dystroglycan binding|cadherin binding|structural molecule activity		VCL/ALK(4)	kidney(4)|ovary(1)|central_nervous_system(1)	6	Prostate(51;0.0112)					CGATGCTGCTCAGGTAGTCAC	0.423		NaN											0	0	0	0.01441	0	35	8									
PKD2L1	9033	broad.mit.edu	37	10	102056962	102056962	+	Silent	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr10:102056962C>T	uc001kqx.1	-	6	1343	c.960G>A	c.(958-960)CTG>CTA	p.L320L	PKD2L1_uc009xwm.1_Silent_p.L273L	NM_016112	NP_057196	Q9P0L9	PK2L1_HUMAN	polycystic kidney disease 2-like 1	320	Helical; (Potential).				signal transduction	integral to membrane	calcium activated cation channel activity|calcium ion binding|cytoskeletal protein binding			ovary(4)	4		Colorectal(252;0.117)		Epithelial(162;6.15e-10)|all cancers(201;5.14e-08)		ACTCCACCACCAGCCTATAGG	0.582		NaN											0	0	0	0.000602	0	4	52									
PDCD11	22984	broad.mit.edu	37	10	105191938	105191938	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr10:105191938G>A	uc001kwy.1	+	22	3508	c.3421G>A	c.(3421-3423)GAG>AAG	p.E1141K		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	1141					mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		TAGCCCCATGGAGAAGATTAA	0.438		NaN											0	0	0	0.00278	0	17	69									
SORCS1	114815	broad.mit.edu	37	10	108371749	108371749	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr10:108371749G>C	uc001kym.2	-	22	2961	c.2953C>G	c.(2953-2955)CCA>GCA	p.P985A	SORCS1_uc001kyl.2_Missense_Mutation_p.P985A|SORCS1_uc009xxs.2_Missense_Mutation_p.P985A|SORCS1_uc001kyn.1_Missense_Mutation_p.P985A|SORCS1_uc001kyo.2_Missense_Mutation_p.P985A	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	985	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		TCCAGGTTTGGAGAAAAGGAC	0.458		NaN											0	0	0	0.004878	0	33	7									
MKI67	4288	broad.mit.edu	37	10	129904104	129904104	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr10:129904104C>G	uc001lke.2	-	13	6195	c.6000G>C	c.(5998-6000)AAG>AAC	p.K2000N	MKI67_uc001lkf.2_Missense_Mutation_p.K1640N|MKI67_uc009yav.1_Missense_Mutation_p.K1575N|MKI67_uc009yaw.1_Missense_Mutation_p.K1150N	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	2000	16 X 122 AA approximate repeats.|9.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				CCAAGGATATCTTGAGTCGTT	0.493		NaN											0	0	0	0.01441	0	168	41									
KRTAP5-4	387267	broad.mit.edu	37	11	1642643	1642643	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr11:1642643C>G	uc009ycy.1	-	4	906	c.819G>C	c.(817-819)AAG>AAC	p.K273N		NM_001012709	NP_001012727	Q6L8H1	KRA54_HUMAN	keratin associated protein 5-4	287						keratin filament					0		all_epithelial(84;0.00819)|Breast(177;0.00832)|Ovarian(85;0.0256)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		AGCCTCAGATCTTACACTGGC	0.547		NaN											0	0	0	0.006214	0	9	159									
TRPM5	29850	broad.mit.edu	37	11	2427906	2427906	+	Missense_Mutation	SNP	C	C	T	rs148532424		TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr11:2427906C>T	uc001lwm.3	-	21	3245	c.3236G>A	c.(3235-3237)CGG>CAG	p.R1079Q	TRPM5_uc010qxl.1_Missense_Mutation_p.R1079Q|TRPM5_uc009ydn.2_Missense_Mutation_p.R1081Q	NM_014555	NP_055370	Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel,	1079	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		GGCGGTTTTCCGCAGCACCTC	0.617		NaN											0	0	0	0.01441	0	74	96									
OR51F1	256892	broad.mit.edu	37	11	4790271	4790271	+	Missense_Mutation	SNP	T	T	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr11:4790271T>C	uc010qyl.1	-	1	877	c.877A>G	c.(877-879)ATC>GTC	p.I293V		NM_001004752	NP_001004752	A6NLW9	A6NLW9_HUMAN	olfactory receptor, family 51, subfamily F,	293						integral to membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.87e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0045)|LUSC - Lung squamous cell carcinoma(625;0.192)		ACACTGTCGATGATGGGGTTG	0.448		NaN											0	0	0	0.01441	0	56	69									
OR2D3	120775	broad.mit.edu	37	11	6942471	6942471	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr11:6942471G>C	uc010rav.1	+	1	239	c.239G>C	c.(238-240)AGA>ACA	p.R80T		NM_001004684	NP_001004684	Q8NGH3	OR2D3_HUMAN	olfactory receptor, family 2, subfamily D,	80	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		TTTTTTCTTAGAAATCTCTCC	0.408		NaN											0	0	0	0.01441	0	55	58									
MRGPRX3	117195	broad.mit.edu	37	11	18159013	18159013	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr11:18159013C>G	uc001mnu.2	+	3	625	c.264C>G	c.(262-264)ATC>ATG	p.I88M		NM_054031	NP_473372	Q96LB0	MRGX3_HUMAN	MAS-related GPR, member X3	88	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|pancreas(1)	2						TACGCCTCATCAATATCCGCC	0.547		NaN											0	0	0	0.00874	0	42	50									
ABTB2	25841	broad.mit.edu	37	11	34181459	34181459	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr11:34181459G>C	uc001mvl.1	-	13	2272	c.2042C>G	c.(2041-2043)TCT>TGT	p.S681C		NM_145804	NP_665803	Q8N961	ABTB2_HUMAN	ankyrin repeat and BTB (POZ) domain containing	681							DNA binding			central_nervous_system(1)|skin(1)	2		Acute lymphoblastic leukemia(5;0.0508)|all_hematologic(20;0.0691)				CTACCTGTTAGAAGCTGTCAC	0.488		NaN											0	0	0	0.009535	0	27	22									
SERPING1	710	broad.mit.edu	37	11	57367761	57367761	+	Missense_Mutation	SNP	A	A	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr11:57367761A>G	uc001nkp.1	+	3	652	c.461A>G	c.(460-462)TAC>TGC	p.Y154C	SERPING1_uc001nkq.1_Missense_Mutation_p.Y154C|SERPING1_uc010rju.1_Missense_Mutation_p.Y102C|SERPING1_uc010rjv.1_Missense_Mutation_p.Y159C|SERPING1_uc001nkr.1_Missense_Mutation_p.Y154C|SERPING1_uc009ymi.1_Missense_Mutation_p.Y154C|SERPING1_uc009ymj.1_Missense_Mutation_p.Y154C|SERPING1_uc001nks.1_Intron	NM_000062	NP_000053	P05155	IC1_HUMAN	serpin peptidase inhibitor, clade G, member 1	154					blood circulation|blood coagulation, intrinsic pathway|complement activation, classical pathway|innate immune response|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation	extracellular space|platelet alpha granule lumen	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)	1						CTGAAGCTCTACCACGCCTTC	0.542		NaN							Hereditary_Angioedema				0	0	0	0.00245	0	10	169									
DAGLA	747	broad.mit.edu	37	11	61507077	61507077	+	Silent	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr11:61507077C>T	uc001nsa.2	+	17	1908	c.1797C>T	c.(1795-1797)CTC>CTT	p.L599L		NM_006133	NP_006124	Q9Y4D2	DGLA_HUMAN	neural stem cell-derived dendrite regulator	599	Cytoplasmic (Potential).				cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3				READ - Rectum adenocarcinoma(4;0.219)		GCACTCCACTCTACCCGCCCG	0.657		NaN											0	0	0	0.01441	0	48	63									
KRTAP5-7	440050	broad.mit.edu	37	11	71238815	71238815	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr11:71238815G>T	uc001oqq.1	+	1	503	c.469G>T	c.(469-471)GTC>TTC	p.V157F		NM_001012503	NP_001012521	Q6L8G8	KRA57_HUMAN	keratin associated protein 5-7	157	7 X 4 AA repeats of C-C-X-P.|7.					keratin filament					0						TAGCTGCTGTGTCCCCGTGTG	0.323		NaN											1	0	2.45186e-53	0.01441	2.679e-53	136	202									
FAT3	120114	broad.mit.edu	37	11	92087838	92087838	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr11:92087838G>A	uc001pdj.3	+	1	2577	c.2560G>A	c.(2560-2562)GAA>AAA	p.E854K		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	854	Cadherin 8.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CATTCAAGTGGAAGCCAGAGA	0.393		NaN								TCGA Ovarian(4;0.039)			0	0	0	0.004656	0	22	27									
KIAA1377	57562	broad.mit.edu	37	11	101868342	101868342	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr11:101868342G>C	uc001pgm.2	+	11	3592	c.3322G>C	c.(3322-3324)GAT>CAT	p.D1108H	KIAA1377_uc001pgn.2_Missense_Mutation_p.D1064H|KIAA1377_uc010run.1_Missense_Mutation_p.D909H	NM_020802	NP_065853	Q9P2H0	K1377_HUMAN	hypothetical protein LOC57562	1108							protein binding			breast(2)|ovary(1)|central_nervous_system(1)	4	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		GAAGAGAGAAGATAGAACCAG	0.428		NaN											0	0	0	0.001168	0	5	88									
DLAT	1737	broad.mit.edu	37	11	111896985	111896985	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr11:111896985G>A	uc001pmo.2	+	2	1002	c.343G>A	c.(343-345)GAG>AAG	p.E115K	DLAT_uc009yyk.1_Missense_Mutation_p.E115K|DLAT_uc010rwr.1_Missense_Mutation_p.E115K	NM_001931	NP_001922	P10515	ODP2_HUMAN	dihydrolipoamide S-acetyltransferase precursor	115	Lipoyl-binding 1.				glycolysis|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial pyruvate dehydrogenase complex	dihydrolipoyllysine-residue acetyltransferase activity|protein binding				0		all_cancers(61;4.53e-11)|all_epithelial(67;2.76e-06)|Melanoma(852;9.42e-06)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0512)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)		Epithelial(105;4.87e-07)|BRCA - Breast invasive adenocarcinoma(274;6.83e-07)|all cancers(92;9.63e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0557)	NADH(DB00157)	GGAAAAAAAAGAGGGGGACAA	0.303		NaN											0	0	0	0.006214	0	5	19									
USP28	57646	broad.mit.edu	37	11	113672370	113672370	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr11:113672370C>T	uc001poh.2	-	24	2926	c.2893G>A	c.(2893-2895)GAA>AAA	p.E965K	USP28_uc001pog.2_Missense_Mutation_p.E641K|USP28_uc010rwy.1_Missense_Mutation_p.E808K|USP28_uc001poi.2_Missense_Mutation_p.E288K	NM_020886	NP_065937	Q96RU2	UBP28_HUMAN	ubiquitin specific protease 28	965					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|breast(2)|ovary(1)|large_intestine(1)|kidney(1)	7		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		TCATTTGTTTCAAAAAGAGAA	0.363		NaN											0	0	0	0.005443	0	20	34									
PHLDB1	23187	broad.mit.edu	37	11	118485345	118485345	+	Silent	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr11:118485345C>T	uc001ptr.1	+	4	485	c.132C>T	c.(130-132)AGC>AGT	p.S44S	PHLDB1_uc010ryh.1_Silent_p.S44S|PHLDB1_uc001pts.2_Silent_p.S44S|PHLDB1_uc001ptt.2_Silent_p.S44S|PHLDB1_uc001ptu.1_RNA	NM_015157	NP_055972	Q86UU1	PHLB1_HUMAN	pleckstrin homology-like domain, family B,	44											0	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		ACCTGGTGAGCCTGGGCAGTG	0.572		NaN											0	0	0	0.00499	0	17	23									
SORL1	6653	broad.mit.edu	37	11	121485651	121485651	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr11:121485651C>G	uc001pxx.2	+	41	5571	c.5491C>G	c.(5491-5493)CTG>GTG	p.L1831V	SORL1_uc010rzp.1_Missense_Mutation_p.L677V|SORL1_uc010rzq.1_Missense_Mutation_p.L446V	NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	1831	Extracellular (Potential).|Fibronectin type-III 3.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		GGATAGCCCTCTGGCATTTGA	0.527		NaN											0	0	0	0.003163	0	14	180									
UBASH3B	84959	broad.mit.edu	37	11	122672000	122672000	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr11:122672000G>C	uc001pyi.3	+	11	1915	c.1555G>C	c.(1555-1557)GAG>CAG	p.E519Q		NM_032873	NP_116262	Q8TF42	UBS3B_HUMAN	ubiquitin associated and SH3 domain containing,	519	Protein tyrosine phosphatase (By similarity).					cytoplasm|nucleus	protein tyrosine phosphatase activity			central_nervous_system(1)	1		Breast(109;0.00254)|Medulloblastoma(222;0.00877)|Lung NSC(97;0.0183)|all_lung(97;0.0186)|all_neural(223;0.0381)|all_hematologic(192;0.104)		BRCA - Breast invasive adenocarcinoma(274;1.37e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0463)		ACCTCCATCAGAGTTAGCTGC	0.488		NaN											0	0	0	0.008871	0	16	206									
OR8B2	26595	broad.mit.edu	37	11	124253209	124253209	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr11:124253209C>T	uc010sai.1	-	1	31	c.31G>A	c.(31-33)GAA>AAA	p.E11K	OR8B2_uc001qab.3_RNA	NM_001005468	NP_001005468	Q96RD0	OR8B2_HUMAN	olfactory receptor, family 8, subfamily B,	11	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		AGAATAAATTCAGTCACTAAG	0.373		NaN											0	0	0	0.010818	0	12	138									
PRDM10	56980	broad.mit.edu	37	11	129785719	129785719	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr11:129785719G>C	uc001qfm.2	-	17	2606	c.2374C>G	c.(2374-2376)CTG>GTG	p.L792V	PRDM10_uc001qfj.2_Missense_Mutation_p.L706V|PRDM10_uc001qfk.2_Missense_Mutation_p.L702V|PRDM10_uc001qfl.2_Missense_Mutation_p.L706V|PRDM10_uc010sbx.1_Missense_Mutation_p.L702V|PRDM10_uc001qfn.2_Missense_Mutation_p.L788V|PRDM10_uc009zcs.1_5'UTR	NM_020228	NP_064613	Q9NQV6	PRD10_HUMAN	PR domain containing 10 isoform 1	792	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1	all_hematologic(175;0.0537)	Breast(109;0.000496)|Lung NSC(97;0.000693)|all_lung(97;0.00151)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0174)|Lung(977;0.176)|LUSC - Lung squamous cell carcinoma(976;0.185)		TGGTTCTTCAGAATGTGGGCT	0.532		NaN											0	0	0	0.001984	0	6	123									
APLP2	334	broad.mit.edu	37	11	130003611	130003611	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr11:130003611C>G	uc010sby.1	+	12	1829	c.1672C>G	c.(1672-1674)CAA>GAA	p.Q558E	APLP2_uc001qfp.2_Missense_Mutation_p.Q558E|APLP2_uc001qfq.2_Missense_Mutation_p.Q502E|APLP2_uc010sbz.1_Missense_Mutation_p.Q346E|APLP2_uc001qfr.2_Missense_Mutation_p.Q324E|APLP2_uc001qfs.2_Missense_Mutation_p.Q329E|APLP2_uc001qfv.2_Missense_Mutation_p.Q449E	NM_001642	NP_001633	Q06481	APLP2_HUMAN	amyloid beta (A4) precursor-like protein 2	558	Extracellular (Potential).				G-protein coupled receptor protein signaling pathway	integral to membrane|nucleus|plasma membrane	DNA binding|identical protein binding|serine-type endopeptidase inhibitor activity			ovary(3)	3	all_hematologic(175;0.0429)	Breast(109;0.00586)|Lung NSC(97;0.00785)|all_lung(97;0.0154)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0197)|Lung(977;0.24)		CCAAGAAATTCAAGAGGAAAT	0.478		NaN											0	0	0	0.009096	0	4	78									
C12orf4	57102	broad.mit.edu	37	12	4639192	4639192	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:4639192C>G	uc001qms.2	-	4	437	c.349G>C	c.(349-351)GAA>CAA	p.E117Q	C12orf4_uc001qmt.2_Missense_Mutation_p.E117Q	NM_020374	NP_065107	Q9NQ89	CL004_HUMAN	hypothetical protein LOC57102	117											0			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)	BRCA - Breast invasive adenocarcinoma(232;0.0281)		CTGGGTTCTTCAGGCCTTGCA	0.343		NaN											0	0	0	0.001168	0	6	96									
KLRC4	8302	broad.mit.edu	37	12	10562024	10562024	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:10562024C>G	uc001qye.2	-	1	333	c.151G>C	c.(151-153)GAT>CAT	p.D51H	KLRK1_uc001qyc.2_5'Flank|KLRK1_uc009zhk.2_5'UTR|KLRK1_uc001qyd.2_Intron	NM_013431	NP_038459	O43908	NKG2F_HUMAN	killer cell lectin-like receptor subfamily C,	51	Cytoplasmic (Potential).				cellular defense response	integral to membrane	binding|receptor activity				0						CCTTGATGATCCGAAGAAGCA	0.353		NaN											0	0	0	0.003163	0	10	140									
TAS2R9	50835	broad.mit.edu	37	12	10962188	10962188	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:10962188C>G	uc001qyx.2	-	1	580	c.487G>C	c.(487-489)GAA>CAA	p.E163Q	TAS2R8_uc010shh.1_5'Flank	NM_023917	NP_076406	Q9NYW1	TA2R9_HUMAN	taste receptor, type 2, member 9	163	Extracellular (Potential).				sensory perception of taste	integral to membrane	taste receptor activity			skin(1)	1						GTAATGTTTTCTTCATGACTG	0.378		NaN											0	0	0	0.00308	0	8	61									
MANSC1	54682	broad.mit.edu	37	12	12491411	12491411	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:12491411C>T	uc001rai.1	-	3	565	c.307G>A	c.(307-309)GAG>AAG	p.E103K	MANSC1_uc010shm.1_Missense_Mutation_p.E37K|MANSC1_uc001raj.1_Missense_Mutation_p.E69K|MANSC1_uc009zht.1_Missense_Mutation_p.E22K	NM_018050	NP_060520	Q9H8J5	MANS1_HUMAN	MANSC domain containing 1 precursor	103	MANSC.|Extracellular (Potential).					integral to membrane					0		Prostate(47;0.0865)		BRCA - Breast invasive adenocarcinoma(232;0.185)		CAGGCTTCCTCGTTGGGACAG	0.383		NaN											0	0	0	0.001984	0	5	159									
PIK3C2G	5288	broad.mit.edu	37	12	18552648	18552648	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:18552648G>A	uc001rdt.2	+	15	2175	c.2059G>A	c.(2059-2061)GAA>AAA	p.E687K	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Missense_Mutation_p.E728K|PIK3C2G_uc010sic.1_Missense_Mutation_p.E506K	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	687					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				CTGCAATAATGAAAACTGCTC	0.388		NaN											0	0	0	0.005443	0	24	48									
ABCC9	10060	broad.mit.edu	37	12	22063765	22063765	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:22063765G>C	uc001rfi.1	-	7	1179	c.1159C>G	c.(1159-1161)CTG>GTG	p.L387V	ABCC9_uc001rfh.2_Missense_Mutation_p.L387V|ABCC9_uc001rfj.1_Missense_Mutation_p.L387V	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	387	Cytoplasmic (Potential).|ABC transmembrane type-1 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CATACCAGCAGAGCTCCACGG	0.393		NaN											0	0	0	0.008871	0	7	105									
FMNL3	91010	broad.mit.edu	37	12	50044977	50044977	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:50044977C>T	uc001ruv.1	-	16	2005	c.1771G>A	c.(1771-1773)GAA>AAA	p.E591K	FMNL3_uc001ruw.1_Missense_Mutation_p.E540K|FMNL3_uc001rut.1_Missense_Mutation_p.E157K|FMNL3_uc001ruu.1_Missense_Mutation_p.E441K	NM_175736	NP_783863	Q8IVF7	FMNL3_HUMAN	formin-like 3 isoform 1	591	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			breast(2)|pancreas(2)	4						TCATCAAGTTCGCTGAAGACA	0.512		NaN											0	0	0	0.008291	0	10	141									
LIMA1	51474	broad.mit.edu	37	12	50642443	50642443	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:50642443G>A	uc001rwj.3	-	2	266	c.92C>T	c.(91-93)TCA>TTA	p.S31L	LIMA1_uc001rwk.3_Missense_Mutation_p.S31L|LIMA1_uc010smr.1_RNA|LIMA1_uc010sms.1_RNA	NM_016357	NP_057441	Q9UHB6	LIMA1_HUMAN	LIM domain and actin binding 1 isoform b	31					actin filament bundle assembly|negative regulation of actin filament depolymerization|ruffle organization	cytoplasm|focal adhesion|stress fiber	actin filament binding|actin monomer binding|zinc ion binding			ovary(1)	1						AATAGCCGATGACTTGTTCTT	0.438		NaN											0	0	0	0.010771	0	41	50									
KRT79	338785	broad.mit.edu	37	12	53227849	53227849	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:53227849C>T	uc001sbb.2	-	1	229	c.196G>A	c.(196-198)GGG>AGG	p.G66R		NM_175834	NP_787028	Q5XKE5	K2C79_HUMAN	keratin 6L	66	Head.					keratin filament	structural molecule activity			ovary(2)|skin(2)	4						TTGTGGCCCCCCAAGTTATAG	0.642		NaN											0	0	0	0.007291	0	28	31									
ESPL1	9700	broad.mit.edu	37	12	53676185	53676185	+	Silent	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:53676185C>G	uc001sck.2	+	14	2848	c.2757C>G	c.(2755-2757)CTC>CTG	p.L919L	ESPL1_uc001scj.2_Silent_p.L594L|ESPL1_uc010soe.1_Silent_p.L130L	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	919					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						CAAACAACCTCTCACACTCCC	0.572		NaN											0	0	0	0.001168	0	5	63									
TIMELESS	8914	broad.mit.edu	37	12	56825382	56825382	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:56825382C>T	uc001slf.2	-	8	862	c.694G>A	c.(694-696)GAG>AAG	p.E232K	TIMELESS_uc001slg.2_Missense_Mutation_p.E231K	NM_003920	NP_003911	Q9UNS1	TIM_HUMAN	timeless homolog	232					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				ovary(5)|breast(2)|pancreas(1)	8						GCCAGCTGCTCGGGGTTCTAG	0.517		NaN											0	0	0	0.000602	0	4	60									
CDK4	1019	broad.mit.edu	37	12	58144834	58144834	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:58144834G>C	uc001spv.2	-	4	621	c.394C>G	c.(394-396)CAT>GAT	p.H132D	CDK4_uc010ssb.1_Missense_Mutation_p.H12D|CDK4_uc001spw.2_Intron|uc010ssc.1_5'Flank	NM_000075	NP_000066	P11802	CDK4_HUMAN	cyclin-dependent kinase 4	132	Protein kinase.				cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|positive regulation of fibroblast proliferation|regulation of gene expression|response to drug|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane	ATP binding|cyclin-dependent protein kinase activity|protein binding			lung(1)|breast(1)|central_nervous_system(1)	3	all_cancers(7;4.96e-69)|Lung NSC(6;5.5e-25)|all_lung(6;3.87e-23)|all_epithelial(6;1.66e-15)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;4.21e-120)|all cancers(5;3.75e-83)|BRCA - Breast invasive adenocarcinoma(9;0.0294)			CAATTGGCATGAAGGAAATCT	0.488		NaN	Mis			melanoma 			Hereditary_Melanoma				0	0	0	0.001168	0	6	75									
CDK4	1019	broad.mit.edu	37	12	58144855	58144855	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:58144855G>C	uc001spv.2	-	4	600	c.373C>G	c.(373-375)CTA>GTA	p.L125V	CDK4_uc010ssb.1_Missense_Mutation_p.L5V|CDK4_uc001spw.2_Intron|uc010ssc.1_5'Flank	NM_000075	NP_000066	P11802	CDK4_HUMAN	cyclin-dependent kinase 4	125	Protein kinase.				cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|positive regulation of fibroblast proliferation|regulation of gene expression|response to drug|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane	ATP binding|cyclin-dependent protein kinase activity|protein binding			lung(1)|breast(1)|central_nervous_system(1)	3	all_cancers(7;4.96e-69)|Lung NSC(6;5.5e-25)|all_lung(6;3.87e-23)|all_epithelial(6;1.66e-15)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;4.21e-120)|all cancers(5;3.75e-83)|BRCA - Breast invasive adenocarcinoma(9;0.0294)			AGGCCTCTTAGAAACTGGCGC	0.483		NaN	Mis			melanoma 			Hereditary_Melanoma				0	0	0	0.000602	0	4	68									
SLC6A15	55117	broad.mit.edu	37	12	85266414	85266414	+	Silent	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:85266414G>C	uc001szv.2	-	8	1762	c.1269C>G	c.(1267-1269)CTC>CTG	p.L423L	SLC6A15_uc010sul.1_Silent_p.L316L|SLC6A15_uc001szw.1_Silent_p.L131L	NM_182767	NP_877499	Q9H2J7	S6A15_HUMAN	solute carrier family 6, member 15 isoform 1	423	Extracellular (Potential).				cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			pancreas(2)|ovary(1)	3						TACAGGAATTGAGATGAAGAG	0.318		NaN											0	0	0	0.012213	0	29	48									
PLXNC1	10154	broad.mit.edu	37	12	94543416	94543416	+	Silent	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:94543416C>G	uc001tdc.2	+	1	918	c.669C>G	c.(667-669)CTC>CTG	p.L223L		NM_005761	NP_005752	O60486	PLXC1_HUMAN	plexin C1 precursor	223	Extracellular (Potential).|Sema.				axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			ovary(2)|central_nervous_system(1)	3						TGGGGCGCCTCAAGCTGTGCG	0.687		NaN											0	0	0	0.004672	0	3	3									
SYCP3	50511	broad.mit.edu	37	12	102122982	102122982	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:102122982C>T	uc001tiq.2	-	8	694	c.562G>A	c.(562-564)GAG>AAG	p.E188K	CHPT1_uc001tip.1_3'UTR|SYCP3_uc001tir.2_Missense_Mutation_p.E188K|SYCP3_uc001tis.2_Missense_Mutation_p.E188K	NM_153694	NP_710161	Q8IZU3	SYCP3_HUMAN	synaptonemal complex protein 3	188	Potential.|Gln-rich.				cell division|male meiosis I|spermatogenesis, exchange of chromosomal proteins	nucleus	DNA binding				0						TTCTCCAACTCTTCCATACTC	0.289		NaN											0	0	0	0.007291	0	25	37									
HCFC2	29915	broad.mit.edu	37	12	104487163	104487163	+	Splice_Site	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:104487163G>A	uc001tkj.3	+	10	1388	c.1285_splice	c.e10-1	p.I429_splice	HCFC2_uc009zul.2_Splice_Site	NM_013320	NP_037452	Q9Y5Z7	HCFC2_HUMAN	host cell factor C2						regulation of transcription from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleus	transcription coactivator activity			ovary(2)|central_nervous_system(1)	3						ATTTCTTGTAGATCAATGATA	0.279		NaN											0	0	0	0.001984	0	7	49									
MMAB	326625	broad.mit.edu	37	12	110002929	110002929	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:110002929G>A	uc001tou.2	-	4	416	c.343C>T	c.(343-345)CAG>TAG	p.Q115*	MMAB_uc001tov.2_RNA|MMAB_uc001tow.2_RNA|MMAB_uc010sxq.1_Nonsense_Mutation_p.Q24*|MMAB_uc001tox.2_Nonsense_Mutation_p.Q63*	NM_052845	NP_443077	Q96EY8	MMAB_HUMAN	cob(I)alamin adenosyltransferase precursor	115					cobalamin biosynthetic process	mitochondrion	ATP binding|cob(I)yrinic acid a,c-diamide adenosyltransferase activity				0					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CTCACTTTCTGAAGCTCTTCG	0.408		NaN											0	0	0	0.003954	0	19	226									
NAA25	80018	broad.mit.edu	37	12	112512548	112512548	+	Missense_Mutation	SNP	T	T	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:112512548T>C	uc001ttm.2	-	9	817	c.797A>G	c.(796-798)TAT>TGT	p.Y266C	NAA25_uc001ttn.3_RNA|NAA25_uc009zvz.1_Missense_Mutation_p.Y238C|NAA25_uc009zwa.1_Missense_Mutation_p.Y266C	NM_024953	NP_079229	Q14CX7	NAA25_HUMAN	mitochondrial distribution and morphology 20	266						cytoplasm	protein binding			ovary(1)|breast(1)|pancreas(1)	3						ATAAGTCAGATAGAACTGCCA	0.398		NaN											0	0	0	0.01441	0	72	106									
OASL	8638	broad.mit.edu	37	12	121465572	121465572	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:121465572G>C	uc001tzj.1	-	4	712	c.706C>G	c.(706-708)CTT>GTT	p.L236V	OASL_uc001tzk.1_Intron	NM_003733	NP_003724	Q15646	OASL_HUMAN	2'-5'-oligoadenylate synthetase-like isoform a	236					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoplasm|nucleolus	ATP binding|DNA binding|double-stranded RNA binding|thyroid hormone receptor binding|transferase activity			skin(1)	1	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					AGAAGTTCAAGAGCATAGAGA	0.473		NaN											0	0	0	0.009096	0	3	78									
GPR81	27198	broad.mit.edu	37	12	123214255	123214255	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:123214255C>G	uc001ucz.2	-	1	875	c.632G>C	c.(631-633)AGA>ACA	p.R211T	GPR81_uc001ucw.1_RNA	NM_032554	NP_115943	Q9BXC0	HCAR1_HUMAN	G protein-coupled receptor 81	211	Cytoplasmic (Potential).				response to estradiol stimulus	integral to membrane|plasma membrane	G-protein coupled receptor activity				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.14e-05)|Epithelial(86;3.25e-05)|BRCA - Breast invasive adenocarcinoma(302;0.197)		CCGAGCCTGTCTGGCCAGCTG	0.527		NaN											0	0	0	0.012213	0	28	38									
GPR81	27198	broad.mit.edu	37	12	123214498	123214498	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:123214498C>T	uc001ucz.2	-	1	632	c.389G>A	c.(388-390)CGG>CAG	p.R130Q	GPR81_uc001ucw.1_RNA	NM_032554	NP_115943	Q9BXC0	HCAR1_HUMAN	G protein-coupled receptor 81	130	Cytoplasmic (Potential).				response to estradiol stimulus	integral to membrane|plasma membrane	G-protein coupled receptor activity				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.14e-05)|Epithelial(86;3.25e-05)|BRCA - Breast invasive adenocarcinoma(302;0.197)		AGCCGCCACCCGGGTGGAGAT	0.602		NaN											0	0	0	0.01441	0	43	54									
FLT3	2322	broad.mit.edu	37	13	28601286	28601286	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr13:28601286C>G	uc001urw.2	-	17	2228	c.2146G>C	c.(2146-2148)GAG>CAG	p.E716Q	FLT3_uc010aao.2_RNA|FLT3_uc010tdn.1_Missense_Mutation_p.E716Q	NM_004119	NP_004110	P36888	FLT3_HUMAN	fms-related tyrosine kinase 3 precursor	716	Protein kinase.|Cytoplasmic (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			haematopoietic_and_lymphoid_tissue(8536)|lung(7)|ovary(3)|stomach(1)|central_nervous_system(1)|skin(1)	8549	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	TTGAAAATCTCTGTCCAAGTC	0.358		NaN	Mis|O		AML|ALL								0	0	0	0.014323	0	18	244									
FRY	10129	broad.mit.edu	37	13	32757127	32757127	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr13:32757127G>C	uc001utx.2	+	24	3506	c.3010G>C	c.(3010-3012)GAA>CAA	p.E1004Q	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	1004					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		ATTGGTAGAAGAACTTCATCC	0.313		NaN											0	0	0	0.001984	0	7	78									
ITM2B	9445	broad.mit.edu	37	13	48832951	48832951	+	Missense_Mutation	SNP	C	C	G	rs11556901		TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr13:48832951C>G	uc001vbz.3	+	5	806	c.583C>G	c.(583-585)CAG>GAG	p.Q195E		NM_021999	NP_068839	Q9Y287	ITM2B_HUMAN	integral membrane protein 2B	195	BRICHOS.|Lumenal (Potential).				nervous system development	Golgi membrane|integral to membrane|nucleus|plasma membrane	beta-amyloid binding				0		all_cancers(8;2.2e-31)|all_epithelial(8;6.77e-15)|all_lung(13;9.67e-07)|all_hematologic(8;9.72e-06)|Lung NSC(96;8.3e-05)|Breast(56;0.000141)|Acute lymphoblastic leukemia(8;0.00045)|Prostate(109;0.000669)|Myeloproliferative disorder(33;0.039)|Hepatocellular(98;0.0556)|Lung SC(185;0.102)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(144;1.97e-06)		CTATTTGCCTCAGTCCTATCT	0.373		NaN											0	0	0	0.001984	0	5	61									
RB1	5925	broad.mit.edu	37	13	48934194	48934194	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr13:48934194C>T	uc001vcb.2	+	7	815	c.649C>T	c.(649-651)CAG>TAG	p.Q217*	RB1_uc010acs.1_RNA|RB1_uc010act.1_5'UTR	NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	217					androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(5)|p.Q217*(2)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GATTTCATTTCAGTTAATGCT	0.308		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			0	0	0	0.01441	0	67	17									
CKAP2	26586	broad.mit.edu	37	13	53039469	53039469	+	Silent	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr13:53039469C>T	uc001vgv.2	+	6	1545	c.1348C>T	c.(1348-1350)CTG>TTG	p.L450L	CKAP2_uc001vgt.2_Silent_p.L449L|CKAP2_uc001vgu.2_Silent_p.L449L|CKAP2_uc010tha.1_Silent_p.L401L	NM_001098525	NP_001091995	Q8WWK9	CKAP2_HUMAN	cytoskeleton associated protein 2 isoform 2	450					apoptosis|cell cycle	centrosome|microtubule|spindle pole				ovary(1)|skin(1)	2		Breast(56;0.000207)|Lung NSC(96;0.00212)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.6e-08)		ACTGAATGACCTGATTAAAAA	0.303		NaN											0	0	0	0.001984	0	5	173									
PCDH8	5100	broad.mit.edu	37	13	53420766	53420766	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr13:53420766C>G	uc001vhi.2	-	1	2009	c.1806G>C	c.(1804-1806)CAG>CAC	p.Q602H	PCDH8_uc001vhj.2_Missense_Mutation_p.Q602H	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	602	Extracellular (Potential).|Cadherin 5.				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		CATGGTCGTTCTGGTCCAGCA	0.662		NaN											0	0	0	0.00308	0	5	10									
DZIP1	22873	broad.mit.edu	37	13	96246297	96246297	+	Silent	SNP	T	T	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr13:96246297T>C	uc001vmk.2	-	16	2433	c.1581A>G	c.(1579-1581)TTA>TTG	p.L527L	DZIP1_uc001vmj.2_Silent_p.L3L|DZIP1_uc001vml.2_Silent_p.L508L	NM_198968	NP_945319	Q86YF9	DZIP1_HUMAN	DAZ interacting protein 1 isoform 2	527					germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			AAGCTTTCCTTAAATGCATTT	0.333		NaN											0	0	0	0.012213	0	34	66									
GAS6	2621	broad.mit.edu	37	13	114523972	114523972	+	Silent	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr13:114523972C>T	uc001vud.2	-	15	2055	c.1902G>A	c.(1900-1902)GCG>GCA	p.A634A	GAS6_uc001vug.2_Silent_p.A335A|GAS6_uc001vuf.2_Silent_p.A361A	NM_000820	NP_000811	Q14393	GAS6_HUMAN	growth arrest-specific 6 isoform 1 precursor	677	Laminin G-like 2.				cell proliferation|leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|post-translational protein modification|proteolysis|regulation of growth	endoplasmic reticulum lumen|extracellular space|Golgi lumen|platelet alpha granule lumen	calcium ion binding|receptor agonist activity			central_nervous_system(4)	4	Lung NSC(43;0.00976)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0176)|all_epithelial(44;0.0104)|all_lung(25;0.0249)|Lung NSC(25;0.0908)|Breast(118;0.188)				CGGTGACTGGCGCTGAAGTCA	0.672		NaN											0	0	0	0.001984	0	4	67									
UPF3A	65110	broad.mit.edu	37	13	115047559	115047559	+	Silent	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr13:115047559C>T	uc001vup.2	+	2	308	c.271C>T	c.(271-273)CTG>TTG	p.L91L	UPF3A_uc010tkn.1_Silent_p.L91L|UPF3A_uc001vuq.2_Silent_p.L91L|UPF3A_uc001vus.2_RNA|UPF3A_uc001vur.2_RNA	NM_023011	NP_075387	Q9H1J1	REN3A_HUMAN	UPF3 regulator of nonsense transcripts homolog A	91	Required for interaction with UPF2.				mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation	cytoplasm|nucleus|plasma membrane	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			skin(1)	1	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0191)|all_epithelial(44;0.00716)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.238)	BRCA - Breast invasive adenocarcinoma(86;0.0886)	OV - Ovarian serous cystadenocarcinoma(48;0.195)|Epithelial(10;0.2)		GCTGCGCCCGCTGCCAGCACA	0.731		NaN											0	0	0	0.004672	0	3	14									
SALL2	6297	broad.mit.edu	37	14	21993420	21993420	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr14:21993420C>T	uc001wbe.2	-	2	724	c.442G>A	c.(442-444)GGA>AGA	p.G148R	SALL2_uc010tly.1_Missense_Mutation_p.G146R|SALL2_uc010tlz.1_Intron|SALL2_uc001wbf.3_Intron|SALL2_uc010tma.1_Intron|SALL2_uc001wbg.1_Intron	NM_005407	NP_005398	Q9Y467	SALL2_HUMAN	sal-like 2	148							DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|large_intestine(1)	3	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		GGGGTTGCTCCCAGCTTGGGA	0.652		NaN											0	0	0	0.01441	0	46	73									
HECTD1	25831	broad.mit.edu	37	14	31626439	31626439	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr14:31626439C>T	uc001wrc.1	-	11	2182	c.1693G>A	c.(1693-1695)GAT>AAT	p.D565N	HECTD1_uc001wrd.1_Missense_Mutation_p.D80N	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	565					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		ACATCAGAATCACAAACTTCT	0.338		NaN											0	0	0	0.01441	0	74	87									
KTN1	3895	broad.mit.edu	37	14	56142555	56142555	+	Silent	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr14:56142555G>A	uc001xcb.2	+	42	4076	c.3774G>A	c.(3772-3774)TTG>TTA	p.L1258L	KTN1_uc001xce.2_Silent_p.L1201L|KTN1_uc001xcc.2_Silent_p.L1258L|KTN1_uc001xcd.2_Silent_p.L1207L|KTN1_uc010trb.1_Silent_p.L1230L|KTN1_uc001xcf.1_Silent_p.L1207L|KTN1_uc010aoq.2_Silent_p.L496L|KTN1_uc010trc.1_Silent_p.L235L|KTN1_uc001xcg.2_Silent_p.L191L	NM_182926	NP_891556	Q86UP2	KTN1_HUMAN	kinectin 1 isoform a	1258	Lumenal (Potential).|Potential.				microtubule-based movement	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction				breast(3)|ovary(2)|lung(1)|central_nervous_system(1)	7						TTTTACAGTTGAAGGCACAGT	0.368		NaN	T	RET	papillary thryoid								0	0	0	0.014323	0	22	32									
KIAA0586	9786	broad.mit.edu	37	14	58954657	58954657	+	Silent	SNP	T	T	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr14:58954657T>G	uc001xdv.3	+	22	3402	c.3129T>G	c.(3127-3129)ACT>ACG	p.T1043T	KIAA0586_uc010trr.1_Silent_p.T1160T|KIAA0586_uc001xdt.3_Silent_p.T1075T|KIAA0586_uc001xdu.3_Silent_p.T1104T|KIAA0586_uc010trs.1_Silent_p.T1034T|KIAA0586_uc010trt.1_Silent_p.T979T|KIAA0586_uc010tru.1_Silent_p.T979T	NM_014749	NP_055564	E9PGW8	E9PGW8_HUMAN	talpid3 protein	1043										ovary(1)	1						TTACCCCTACTACTACACCTC	0.418		NaN											0	0	0	0.010729	0	10	19									
SYNE2	23224	broad.mit.edu	37	14	64619413	64619413	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr14:64619413G>C	uc001xgm.2	+	85	16001	c.15771G>C	c.(15769-15771)AAG>AAC	p.K5257N	SYNE2_uc001xgl.2_Missense_Mutation_p.K5257N|SYNE2_uc010apy.2_Missense_Mutation_p.K1642N|SYNE2_uc001xgn.2_Missense_Mutation_p.K219N|SYNE2_uc001xgo.2_RNA	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	5257	Spectrin 3.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TATTTCAAAAGAGAAGCAGTG	0.373		NaN											0	0	0	0.001984	0	5	85									
ZFYVE26	23503	broad.mit.edu	37	14	68260378	68260378	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr14:68260378C>G	uc001xka.2	-	14	2639	c.2500G>C	c.(2500-2502)GAG>CAG	p.E834Q	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkc.3_Missense_Mutation_p.E834Q	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	834					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		AGCAGTGACTCAGGTGGGGAG	0.552		NaN											0	0	0	0.01441	0	44	24									
PSEN1	5663	broad.mit.edu	37	14	73637508	73637508	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr14:73637508G>A	uc001xnr.2	+	4	375	c.91G>A	c.(91-93)GAC>AAC	p.D31N	PSEN1_uc001xnv.2_Missense_Mutation_p.D27N|PSEN1_uc010ark.2_Missense_Mutation_p.D27N|PSEN1_uc001xnt.1_RNA|PSEN1_uc001xnu.2_RNA|PSEN1_uc001xnq.3_Missense_Mutation_p.D31N	NM_000021	NP_000012	P49768	PSN1_HUMAN	presenilin 1 isoform I-467	31	Cytoplasmic (Potential).				amyloid precursor protein catabolic process|anti-apoptosis|beta-amyloid metabolic process|cell-cell adhesion|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|smooth endoplasmic reticulum calcium ion homeostasis	apical plasma membrane|axon|cell cortex|cell surface|centrosome|ciliary rootlet|dendritic shaft|endoplasmic reticulum membrane|gamma-secretase complex|Golgi membrane|growth cone|integral to plasma membrane|kinetochore|lysosomal membrane|membrane raft|mitochondrial inner membrane|neuromuscular junction|neuronal cell body|nuclear outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum|smooth endoplasmic reticulum|Z disc	aspartic-type endopeptidase activity|beta-catenin binding|cadherin binding|calcium channel activity|PDZ domain binding			breast(1)|kidney(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.075)		CTTATAGAATGACAATAGAGA	0.483		NaN											0	0	0	0.000602	0	4	39									
LIN52	91750	broad.mit.edu	37	14	74567922	74567922	+	Silent	SNP	T	T	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr14:74567922T>C	uc001xpp.2	+	5	286	c.276T>C	c.(274-276)TAT>TAC	p.Y92Y	LIN52_uc010asb.2_Intron	NM_001024674	NP_001019845	Q52LA3	LIN52_HUMAN	lin-52 homolog	92										breast(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00471)		ACCTAGCCTATCAGCTGGGGC	0.488		NaN											0	0	0	0.012213	0	28	71									
C14orf115	55237	broad.mit.edu	37	14	74825046	74825046	+	Silent	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr14:74825046G>C	uc001xpw.3	+	2	1751	c.1560G>C	c.(1558-1560)CTG>CTC	p.L520L		NM_018228	NP_060698	Q9H8Y1	VRTN_HUMAN	hypothetical protein LOC55237	520					transposition, DNA-mediated		DNA binding|transposase activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00147)		GGCAGGTGCTGAGTGGGCATC	0.672		NaN											0	0	0	0.01441	0	43	100									
GSTZ1	2954	broad.mit.edu	37	14	77797454	77797454	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr14:77797454C>G	uc001xtj.2	+	9	849	c.567C>G	c.(565-567)ATC>ATG	p.I189M	GSTZ1_uc001xtk.2_Missense_Mutation_p.I147M|GSTZ1_uc010ass.2_Missense_Mutation_p.I134M|GSTZ1_uc001xtm.2_Missense_Mutation_p.I134M	NM_145870	NP_665877	O43708	MAAI_HUMAN	glutathione transferase zeta 1 isoform 1	189	GST C-terminal.				glutathione metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process	cytosol|mitochondrion	glutathione peroxidase activity|glutathione transferase activity|maleylacetoacetate isomerase activity|protein homodimerization activity				0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0281)	Glutathione(DB00143)	TCAGCTCCATCAACAAGAGGC	0.567		NaN											0	0	0	0.01441	0	54	47									
SERPINA9	327657	broad.mit.edu	37	14	94936059	94936059	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr14:94936059G>C	uc001ydf.2	-	2	334	c.173C>G	c.(172-174)CCT>CGT	p.P58R	SERPINA9_uc001yde.2_Missense_Mutation_p.P58R|SERPINA9_uc010avc.2_Intron|SERPINA9_uc001ydg.2_Intron|SERPINA9_uc001ydh.1_Missense_Mutation_p.P58R|SERPINA9_uc001ydi.1_Intron	NM_175739	NP_783866	Q86WD7	SPA9_HUMAN	serine (or cysteine) proteinase inhibitor, clade	40					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			lung(1)|central_nervous_system(1)	2		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		CTGTGAGGCAGGGGTGCTCTT	0.577		NaN											0	0	0	0.013537	0	10	73									
RAGE	5891	broad.mit.edu	37	14	102718331	102718331	+	Silent	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr14:102718331C>G	uc001ylm.2	-	5	511	c.285G>C	c.(283-285)GGG>GGC	p.G95G	RAGE_uc010txv.1_Silent_p.G65G|RAGE_uc001yln.2_5'UTR	NM_014226	NP_055041	Q9UQ07	MOK_HUMAN	MAPK/MAK/MRK overlapping kinase	95	Protein kinase.				signal transduction	Golgi apparatus	ATP binding|cyclin-dependent protein kinase activity|protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4						GGTATCTTCTCCCTGTACAAT	0.318		NaN											0	0	0	0.001168	0	5	71									
KIF26A	26153	broad.mit.edu	37	14	104642805	104642805	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr14:104642805G>A	uc001yos.3	+	12	3680	c.3680G>A	c.(3679-3681)CGC>CAC	p.R1227H		NM_015656	NP_056471	Q9ULI4	KI26A_HUMAN	kinesin family member 26A	1227					blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			pancreas(1)	1		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		GGCTGTGCTCGCCTGGGCCAG	0.701		NaN											0	0	0	0.00499	0	16	21									
NUSAP1	51203	broad.mit.edu	37	15	41657646	41657646	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr15:41657646G>C	uc001zns.3	+	7	937	c.707G>C	c.(706-708)AGA>ACA	p.R236T	NUSAP1_uc001znq.3_Missense_Mutation_p.R41T|NUSAP1_uc001znr.3_Missense_Mutation_p.R235T|NUSAP1_uc010bce.2_Missense_Mutation_p.R236T|NUSAP1_uc001znt.3_Missense_Mutation_p.R221T|NUSAP1_uc001znv.3_Missense_Mutation_p.R234T|NUSAP1_uc001znu.3_Missense_Mutation_p.R235T|NUSAP1_uc010ucw.1_Missense_Mutation_p.R212T|NUSAP1_uc001znw.3_Missense_Mutation_p.R40T	NM_016359	NP_057443	Q9BXS6	NUSAP_HUMAN	nucleolar and spindle associated protein 1	236					cytokinesis after mitosis|establishment of mitotic spindle localization|mitotic chromosome condensation|positive regulation of mitosis	chromosome|cytoplasm|nucleolus	DNA binding				0		all_cancers(109;5.07e-19)|all_epithelial(112;2.43e-16)|Lung NSC(122;1.81e-11)|all_lung(180;4.81e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;9.63e-17)|GBM - Glioblastoma multiforme(113;1.59e-06)|BRCA - Breast invasive adenocarcinoma(123;0.168)		GTACCTCCAAGAGGAAGACTC	0.493		NaN											0	0	0	0.00308	0	6	6									
SHC4	399694	broad.mit.edu	37	15	49255156	49255156	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr15:49255156G>T	uc001zxb.1	-	1	486	c.57C>A	c.(55-57)TTC>TTA	p.F19L		NM_203349	NP_976224	Q6S5L8	SHC4_HUMAN	rai-like protein	19	CH2.				intracellular signal transduction	cell junction|postsynaptic membrane				ovary(3)|pancreas(2)	5		all_lung(180;0.00466)		all cancers(107;9.4e-08)|GBM - Glioblastoma multiforme(94;5.94e-07)		CGGGGTGCCCGAAGAGTCCTA	0.592		NaN											1	0	4.85316e-53	0.01441	5.28836e-53	81	27									
IGDCC4	57722	broad.mit.edu	37	15	65702611	65702611	+	Silent	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr15:65702611C>T	uc002aou.1	-	3	678	c.468G>A	c.(466-468)GAG>GAA	p.E156E		NM_020962	NP_066013	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member	156	Ig-like C2-type 2.|Extracellular (Potential).					integral to membrane|plasma membrane		p.E156V(1)		ovary(1)|pancreas(1)|skin(1)	3						CTGTCCCGTTCTCCTCCACCG	0.577		NaN											0	0	0	0.000602	0	3	59									
MPI	4351	broad.mit.edu	37	15	75183866	75183866	+	Silent	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr15:75183866C>T	uc002azc.1	+	3	296	c.291C>T	c.(289-291)CTC>CTT	p.L97L	MPI_uc010ulv.1_Silent_p.L97L|MPI_uc010ulw.1_Silent_p.L47L|MPI_uc002azd.1_Silent_p.L97L|MPI_uc010ulx.1_Silent_p.L47L|MPI_uc002aze.1_Silent_p.L97L	NM_002435	NP_002426	P34949	MPI_HUMAN	mannose-6- phosphate isomerase	97					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol	mannose-6-phosphate isomerase activity|zinc ion binding			ovary(2)	2						TGCCCTTCCTCTTCAAAGTGC	0.527		NaN											0	0	0	0.006122	0	18	108									
UNC45A	55898	broad.mit.edu	37	15	91483695	91483695	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr15:91483695C>G	uc002bqg.2	+	6	1019	c.679C>G	c.(679-681)CAG>GAG	p.Q227E	UNC45A_uc002bqd.2_Missense_Mutation_p.Q212E|UNC45A_uc010uqo.1_Missense_Mutation_p.Q219E|UNC45A_uc010uqp.1_RNA|UNC45A_uc010uqq.1_Missense_Mutation_p.Q227E	NM_018671	NP_061141	Q9H3U1	UN45A_HUMAN	smooth muscle cell associated protein-1 isoform	227					cell differentiation|muscle organ development	nucleus|perinuclear region of cytoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			CTCTGAGCATCAGTCACGGGT	0.433		NaN											0	0	0	0.00308	0	6	37									
WDR90	197335	broad.mit.edu	37	16	700002	700002	+	Silent	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr16:700002G>A	uc002cii.1	+	3	168	c.114G>A	c.(112-114)CTG>CTA	p.L38L	WDR90_uc002cig.1_Silent_p.L38L|WDR90_uc002cih.1_Silent_p.L38L|WDR90_uc002cij.1_RNA	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90	38										ovary(1)	1		Hepatocellular(780;0.0218)				ACAAGACCCTGAAGGGCGCCG	0.667		NaN											0	0	0	0.008291	0	11	53									
TIGD7	91151	broad.mit.edu	37	16	3349173	3349173	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr16:3349173C>T	uc002cus.2	-	1	2228	c.1442G>A	c.(1441-1443)AGA>AAA	p.R481K	ZNF263_uc002cur.2_3'UTR	NM_033208	NP_149985	Q6NT04	TIGD7_HUMAN	tigger transposable element derived 7	481					regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0						CAAACTCTCTCTTACAGCAGA	0.393		NaN											0	0	0	0.01441	0	74	15									
CREBBP	1387	broad.mit.edu	37	16	3820785	3820785	+	Nonsense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr16:3820785G>C	uc002cvv.2	-	14	2870	c.2666C>G	c.(2665-2667)TCA>TGA	p.S889*	CREBBP_uc002cvw.2_Nonsense_Mutation_p.S851*	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	889					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		CACAGGAGTTGATGGCTGAGT	0.642		NaN	T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				0	0	0	0.00308	0	6	35									
GP2	2813	broad.mit.edu	37	16	20331027	20331027	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr16:20331027C>G	uc002dgv.2	-	7	1014	c.931G>C	c.(931-933)GAC>CAC	p.D311H	GP2_uc002dgw.2_Missense_Mutation_p.D308H|GP2_uc002dgx.2_Missense_Mutation_p.D164H|GP2_uc002dgy.2_Missense_Mutation_p.D161H	NM_001007240	NP_001007241	P55259	GP2_HUMAN	zymogen granule membrane glycoprotein 2 isoform	311	ZP.					anchored to membrane|extracellular region|plasma membrane				ovary(3)|skin(1)	4						AGGATGGTGTCTCTGATGATG	0.438		NaN											0	0	0	0.01441	0	117	23									
ACSM2B	348158	broad.mit.edu	37	16	20552067	20552067	+	Nonsense_Mutation	SNP	G	G	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr16:20552067G>T	uc002dhj.3	-	14	1748	c.1538C>A	c.(1537-1539)TCG>TAG	p.S513*	ACSM2B_uc002dhk.3_Nonsense_Mutation_p.S513*	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	513					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						TAGGAACTGCGAGGCCAGGAT	0.478		NaN											1	0	8.16569e-41	0.01441	8.77867e-41	67	13									
ZNF689	115509	broad.mit.edu	37	16	30616005	30616005	+	Silent	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr16:30616005G>C	uc002dyx.2	-	3	1403	c.1083C>G	c.(1081-1083)CTC>CTG	p.L361L	ZNF689_uc010bzy.2_Missense_Mutation_p.S17C	NM_138447	NP_612456	Q96CS4	ZN689_HUMAN	zinc finger protein HIT-39	361	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			Colorectal(24;0.198)			GCTGGTGCTGGAGCAGCGTGC	0.687		NaN											0	0	0	0.009096	0	2	9									
ZNF689	115509	broad.mit.edu	37	16	30616651	30616651	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr16:30616651G>A	uc002dyx.2	-	3	757	c.437C>T	c.(436-438)TCC>TTC	p.S146F	ZNF689_uc010bzy.2_5'UTR	NM_138447	NP_612456	Q96CS4	ZN689_HUMAN	zinc finger protein HIT-39	146					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			Colorectal(24;0.198)			GGGGCCCCCGGACGTCTGCCT	0.602		NaN											0	0	0	0.003163	0	12	76									
KCTD19	146212	broad.mit.edu	37	16	67323532	67323532	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr16:67323532C>G	uc002esu.2	-	16	2772	c.2721G>C	c.(2719-2721)CAG>CAC	p.Q907H	KCTD19_uc002est.2_Missense_Mutation_p.Q679H|KCTD19_uc010vjj.1_Missense_Mutation_p.Q650H	NM_001100915	NP_001094385	Q17RG1	KCD19_HUMAN	potassium channel tetramerisation domain	907						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		ACAGGCCCCTCTGGATGAGCA	0.562		NaN											0	0	0	0.01441	0	60	15									
CDH13	1012	broad.mit.edu	37	16	83704469	83704469	+	Silent	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr16:83704469C>T	uc002fgx.2	+	9	1296	c.1176C>T	c.(1174-1176)ACC>ACT	p.T392T	CDH13_uc010vns.1_Silent_p.T439T|CDH13_uc010vnt.1_Silent_p.T138T|CDH13_uc010vnu.1_Silent_p.T353T	NM_001257	NP_001248	P55290	CAD13_HUMAN	cadherin 13 preproprotein	392	Cadherin 3.			T -> A (in Ref. 4; AAH28624/AAH30653).	adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		ATGACCCCACCACAGGTGCAT	0.498		NaN											0	0	0	0.01441	0	47	6									
MYO1C	4641	broad.mit.edu	37	17	1370776	1370776	+	Silent	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:1370776G>A	uc002fsp.2	-	30	3283	c.3063C>T	c.(3061-3063)GGC>GGT	p.G1021G	MYO1C_uc002fsn.2_Silent_p.G1002G|MYO1C_uc002fso.2_Silent_p.G986G	NM_001080779	NP_001074248	O00159	MYO1C_HUMAN	myosin IC isoform a	1021					mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity				0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		CGCCTCACCTGCCCTGGTTGA	0.677		NaN											0	0	0	0.010729	0	10	68									
TEKT1	83659	broad.mit.edu	37	17	6703366	6703366	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:6703366G>A	uc002gdt.2	-	8	1347	c.1237C>T	c.(1237-1239)CGC>TGC	p.R413C	TEKT1_uc010vth.1_Missense_Mutation_p.R267C	NM_053285	NP_444515	Q969V4	TEKT1_HUMAN	tektin 1	413					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(1)|skin(1)	2		Myeloproliferative disorder(207;0.0255)				GCATCAGGGCGGAGGCCCCCA	0.488		NaN											0	0	0	0.01441	0	63	105									
TP53	7157	broad.mit.edu	37	17	7577538	7577538	+	Missense_Mutation	SNP	C	C	T	rs11540652		TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:7577538C>T	uc002gim.2	-	7	937	c.743G>A	c.(742-744)CGG>CAG	p.R248Q	TP53_uc002gig.1_Missense_Mutation_p.R248Q|TP53_uc002gih.2_Missense_Mutation_p.R248Q|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116Q|TP53_uc010cng.1_Missense_Mutation_p.R116Q|TP53_uc002gii.1_Missense_Mutation_p.R116Q|TP53_uc010cnh.1_Missense_Mutation_p.R248Q|TP53_uc010cni.1_Missense_Mutation_p.R248Q|TP53_uc002gij.2_Missense_Mutation_p.R248Q|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155Q|TP53_uc002gio.2_Missense_Mutation_p.R116Q	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(523)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.R155Q(4)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572	R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIN87_STOMACH)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NIHOVCAR3_OVARY)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(HCC70_BREAST)|R248Q(KYSE150_OESOPHAGUS)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PC14_LUNG)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.01441	0	63	11									
PIGL	9487	broad.mit.edu	37	17	16137360	16137360	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:16137360C>G	uc002gpv.2	+	2	343	c.311C>G	c.(310-312)TCC>TGC	p.S104C	PIGL_uc010vwd.1_Missense_Mutation_p.S104C	NM_004278	NP_004269	Q9Y2B2	PIGL_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	104	Cytoplasmic (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	N-acetylglucosaminylphosphatidylinositol deacetylase activity				0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0934)		ATTCCACTCTCCAGTGTAATG	0.333		NaN											0	0	0	0.01441	0	79	8									
FAM83G	644815	broad.mit.edu	37	17	18880947	18880947	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:18880947C>G	uc002guw.2	-	5	2199	c.2032G>C	c.(2032-2034)GAT>CAT	p.D678H	SLC5A10_uc002gur.1_Intron|SLC5A10_uc002guu.1_Intron|SLC5A10_uc002gut.1_Intron|SLC5A10_uc002guv.1_Intron|SLC5A10_uc010vyl.1_Intron	NM_001039999	NP_001035088	A6ND36	FA83G_HUMAN	hypothetical protein LOC644815	678										ovary(1)|central_nervous_system(1)	2						TTCAACGCATCTGCTTCTTCT	0.652		NaN											0	0	0	0.013537	0	10	60									
MAPK7	5598	broad.mit.edu	37	17	19285429	19285429	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:19285429C>T	uc002gvn.2	+	5	2199	c.1813C>T	c.(1813-1815)CCT>TCT	p.P605S	MAPK7_uc002gvo.2_Missense_Mutation_p.P466S|MAPK7_uc002gvq.2_Missense_Mutation_p.P605S|MAPK7_uc002gvp.2_Missense_Mutation_p.P605S|uc010vyt.1_5'Flank	NM_139033	NP_620602	Q13164	MK07_HUMAN	mitogen-activated protein kinase 7 isoform 1	605	May not be required for kinase activity; required to stimulate MEF2C activity (By similarity).|Pro-rich.				cell cycle|cell differentiation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|protein binding			central_nervous_system(4)|lung(3)|stomach(1)|skin(1)	9	all_cancers(12;2.87e-05)|all_epithelial(12;0.00114)|Hepatocellular(7;0.00345)|Breast(13;0.206)					ACCTACCAGTCCTCCTCCTGG	0.423		NaN											0	0	0	0.003163	0	13	0									
DHRS7B	25979	broad.mit.edu	37	17	21086979	21086979	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:21086979G>A	uc002gyo.2	+	4	409	c.382G>A	c.(382-384)GAG>AAG	p.E128K		NM_015510	NP_056325	Q6IAN0	DRS7B_HUMAN	dehydrogenase/reductase (SDR family) member 7B	128	Peroxisomal (Potential).					integral to membrane|peroxisomal membrane	binding|oxidoreductase activity			pancreas(1)	1						AGCAGCAGCTGAGATCCTGCA	0.498		NaN											0	0	0	0.009535	0	27	37									
RAB11FIP4	84440	broad.mit.edu	37	17	29857477	29857477	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:29857477C>T	uc002hgn.1	+	14	2016	c.1787C>T	c.(1786-1788)TCG>TTG	p.S596L	RAB11FIP4_uc002hgo.2_Missense_Mutation_p.S494L	NM_032932	NP_116321	Q86YS3	RFIP4_HUMAN	RAB11 family interacting protein 4 (class II)	596	Potential.|Necessary for interaction with RAB11A, subcellular location, homo- or heterooligomerization.|FIP-RBD.				cytokinesis|interspecies interaction between organisms|protein transport	cleavage furrow|endocytic vesicle|midbody|recycling endosome membrane	ADP-ribosylation factor binding|calcium ion binding|protein homodimerization activity|Rab GTPase binding			skin(1)	1		all_cancers(10;3.62e-13)|all_epithelial(10;0.000387)|all_lung(9;0.0132)|Breast(31;0.014)|all_hematologic(16;0.015)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0259)|Ovarian(249;0.0423)|Lung NSC(157;0.066)				GACACCGCCTCGCGCGATGAG	0.582		NaN											0	0	0	0.01441	0	67	61									
RAD51L3	5892	broad.mit.edu	37	17	33430494	33430494	+	Silent	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:33430494G>A	uc002hir.2	-	7	902	c.646C>T	c.(646-648)CTG>TTG	p.L216L	RFFL_uc002hiq.2_Silent_p.L57L|RAD51L3_uc010ctj.2_Missense_Mutation_p.S34F|RAD51L3_uc010wcd.1_Silent_p.L236L|RAD51L3_uc002his.2_Silent_p.L104L|RAD51L3_uc010ctk.2_Silent_p.L97L|RAD51L3_uc010wce.1_Silent_p.L97L|RAD51L3_uc002hit.2_Silent_p.L97L|RAD51L3_uc002hiu.2_Silent_p.L39L	NM_002878	NP_002869	O75771	RA51D_HUMAN	RAD51-like 3 isoform 1	216					DNA repair|reciprocal meiotic recombination	nucleus	ATP binding|DNA binding|DNA-dependent ATPase activity|protein binding				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		TGACCTCCCAGAAGTGGGGAA	0.592		NaN						Direct_reversal_of_damage|Homologous_recombination					0	0	0	0.01441	0	47	66									
MED1	5469	broad.mit.edu	37	17	37587411	37587411	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:37587411C>G	uc002hrv.3	-	9	818	c.606G>C	c.(604-606)AAG>AAC	p.K202N	MED1_uc010wee.1_Missense_Mutation_p.K30N|MED1_uc002hru.2_Missense_Mutation_p.K202N	NM_004774	NP_004765	Q15648	MED1_HUMAN	mediator complex subunit 1	202	Interaction with ESR1.|Interaction with the Mediator complex.|Interaction with the Mediator complex and THRA.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			lung(2)|ovary(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	8		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		CATGAAGAATCTTATCCAAGG	0.393		NaN								HNSCC(31;0.082)			0	0	0	0.01441	0	83	114									
KRT33A	3883	broad.mit.edu	37	17	39502796	39502796	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:39502796C>A	uc002hwk.1	-	6	1038	c.1001G>T	c.(1000-1002)CGG>CTG	p.R334L		NM_004138	NP_004129	O76009	KT33A_HUMAN	keratin 33A	334	Coil 2.|Rod.					intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000496)				CTGGTTCTGCCGCTCCAGGTC	0.632		NaN											1	0	5.78178e-49	0.01441	6.24931e-49	84	108									
KRT34	3885	broad.mit.edu	37	17	39538044	39538044	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:39538044G>C	uc002hwm.2	-	2	490	c.478C>G	c.(478-480)CTG>GTG	p.L160V		NM_021013	NP_066293	O76011	KRT34_HUMAN	keratin 34	160	Rod.|Coil 1B.				epidermis development	intermediate filament	protein binding|structural molecule activity			central_nervous_system(1)	1		Breast(137;0.000496)				TTGGCACACAGAATCTGAAAA	0.483		NaN											0	0	0	0.01441	0	39	45									
UBTF	7343	broad.mit.edu	37	17	42284923	42284923	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:42284923C>T	uc002igb.2	-	19	2135	c.2068G>A	c.(2068-2070)GAG>AAG	p.E690K	UBTF_uc002igc.2_Missense_Mutation_p.E653K|UBTF_uc010czs.2_Missense_Mutation_p.E690K|UBTF_uc002igd.2_Missense_Mutation_p.E653K|UBTF_uc010czt.2_Missense_Mutation_p.E690K	NM_014233	NP_055048	P17480	UBF1_HUMAN	upstream binding transcription factor, RNA	690	Asp/Glu/Ser-rich (acidic).				positive regulation of transcription from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm	DNA binding|protein binding				0		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.114)		tcttcatcctcgtcctcgtca	0.428		NaN											0	0	0	0.004007	0	16	26									
MAPT	4137	broad.mit.edu	37	17	44067367	44067368	+	Missense_Mutation	DNP	CC	CC	AT			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:44067367_44067368CC>AT	uc002ijr.3	+	8	1626_1627	c.1306_1307CC>AT	c.(1306-1308)CCT>ATT	p.P436I	MAPT_uc010dau.2_Missense_Mutation_p.P436I|MAPT_uc002ijs.3_Intron|MAPT_uc002ijx.3_Intron|MAPT_uc002ijt.3_Intron|MAPT_uc002iju.3_Intron|MAPT_uc002ijv.3_Intron	NM_016835	NP_058519	P10636	TAU_HUMAN	microtubule-associated protein tau isoform 1	436					cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			pancreas(1)	1		Melanoma(429;0.216)				CCCAGAGCCACCTTCCTCTCCT	0.515		NaN											0	0	0	0.004672	0	126	151									
MAPT	4137	broad.mit.edu	37	17	44067427	44067427	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:44067427G>A	uc002ijr.3	+	8	1686	c.1366G>A	c.(1366-1368)GAG>AAG	p.E456K	MAPT_uc010dau.2_Missense_Mutation_p.E456K|MAPT_uc002ijs.3_Intron|MAPT_uc002ijx.3_Intron|MAPT_uc002ijt.3_Intron|MAPT_uc002iju.3_Intron|MAPT_uc002ijv.3_Intron	NM_016835	NP_058519	P10636	TAU_HUMAN	microtubule-associated protein tau isoform 1	456					cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			pancreas(1)	1		Melanoma(429;0.216)				TGGAGCAAAGGAGATGAAACT	0.453		NaN											0	0	0	0.00623	0	31	44									
TTLL6	284076	broad.mit.edu	37	17	46863537	46863537	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:46863537C>T	uc010wlo.1	-	13	1785	c.1750G>A	c.(1750-1752)GCC>ACC	p.A584T	TTLL6_uc002iob.2_Missense_Mutation_p.A277T|TTLL6_uc010dbi.2_RNA|TTLL6_uc002ioc.2_Missense_Mutation_p.A337T|TTLL6_uc002iod.2_Missense_Mutation_p.A431T	NM_001130918	NP_001124390	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	536						cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity				0						TGTTTGGAGGCTTGGGTGGCG	0.587		NaN											0	0	0	0.01441	0	231	305									
SPOP	8405	broad.mit.edu	37	17	47699430	47699430	+	Splice_Site	SNP	C	C	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:47699430C>A	uc010dbk.2	-	4	711	c.79_splice	c.e4-1	p.I27_splice	SPOP_uc002ipb.2_Splice_Site_p.I27_splice|SPOP_uc002ipc.2_Splice_Site_p.I27_splice|SPOP_uc002ipd.2_Splice_Site_p.I27_splice|SPOP_uc002ipe.2_Splice_Site_p.I27_splice|SPOP_uc002ipf.2_Splice_Site_p.I27_splice|SPOP_uc002ipg.2_Splice_Site_p.I27_splice	NM_003563	NP_003554	O43791	SPOP_HUMAN	speckle-type POZ protein						mRNA processing	nucleus	protein binding			prostate(2)|ovary(2)|lung(2)	6						CTACCTTGATCTGTTGATAGA	0.398		NaN								Prostate(2;0.17)			1	0	5.03518e-11	0.007413	5.31344e-11	14	21									
UTP18	51096	broad.mit.edu	37	17	49337968	49337968	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:49337968G>A	uc002its.2	+	1	72	c.23G>A	c.(22-24)CGA>CAA	p.R8Q	MBTD1_uc002itr.3_5'Flank|MBTD1_uc002itq.3_5'Flank	NM_016001	NP_057085	Q9Y5J1	UTP18_HUMAN	UTP18, small subunit processome component	8					rRNA processing	nucleolus					0			BRCA - Breast invasive adenocarcinoma(22;2.09e-07)			CGGAGGAGACGAATGAAACTG	0.687		NaN											0	0	0	0.006214	0	7	19									
MARCH10	162333	broad.mit.edu	37	17	60813767	60813767	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:60813767C>A	uc010ddr.2	-	6	1700	c.1462G>T	c.(1462-1464)GAC>TAC	p.D488Y	MARCH10_uc002jag.3_Missense_Mutation_p.D488Y|MARCH10_uc010dds.2_Missense_Mutation_p.D526Y|MARCH10_uc002jah.2_Missense_Mutation_p.D487Y|uc002jaj.1_RNA|uc002jak.2_RNA	NM_001100875	NP_001094345	Q8NA82	MARHA_HUMAN	ring finger protein 190	488							ligase activity|zinc ion binding				0						ATTGACAAGTCTACTGGAATA	0.433		NaN											1	0	6.31663e-08	0.003163	6.56209e-08	13	133									
GPR142	350383	broad.mit.edu	37	17	72368385	72368385	+	Silent	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:72368385G>A	uc010wqy.1	+	4	1035	c.1035G>A	c.(1033-1035)CGG>CGA	p.R345R	GPR142_uc010wqx.1_Silent_p.R257R	NM_181790	NP_861455	Q7Z601	GP142_HUMAN	G protein-coupled receptor 142	345	Cytoplasmic (Potential).					cell junction|cytoplasm|integral to membrane	G-protein coupled receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						GGAGGGGCCGGAGTGGGCTGC	0.627		NaN											0	0	0	0.00632	0	27	33									
NUP85	79902	broad.mit.edu	37	17	73231773	73231773	+	Silent	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:73231773G>A	uc002jng.1	+	19	2230	c.1970G>A	c.(1969-1971)TGA>TAA	p.*657*	NUP85_uc010dgd.1_Silent_p.*612*|NUP85_uc010wrv.1_Silent_p.*611*|NUP85_uc002jnh.1_Silent_p.*260*	NM_024844	NP_079120	Q9BW27	NUP85_HUMAN	nucleoporin 85	657					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|nuclear membrane|Nup107-160 complex|spindle	protein binding			ovary(1)	1	all_lung(278;0.14)|Lung NSC(278;0.168)		all cancers(21;3.45e-06)			GAAGGTTCCTGAGAACTGCTT	0.398		NaN											0	0	0	0.008291	0	8	70									
SAP30BP	29115	broad.mit.edu	37	17	73695901	73695901	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:73695901G>A	uc002jpe.2	+	5	400	c.346G>A	c.(346-348)GAA>AAA	p.E116K	SAP30BP_uc002jpc.1_RNA|SAP30BP_uc010wsf.1_RNA|SAP30BP_uc010wsg.1_RNA|SAP30BP_uc002jpf.2_Missense_Mutation_p.E100K	NM_013260	NP_037392	Q9UHR5	S30BP_HUMAN	transcriptional regulator protein	116					apoptosis|induction of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			ovary(1)	1	all_cancers(13;6.42e-08)		all cancers(21;4.25e-07)|Epithelial(20;9.57e-07)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			GTCGCCTGATGAAATCAAGAT	0.428		NaN											0	0	0	0.01441	0	73	175									
SAP30BP	29115	broad.mit.edu	37	17	73695932	73695932	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:73695932G>C	uc002jpe.2	+	5	431	c.377G>C	c.(376-378)AGA>ACA	p.R126T	SAP30BP_uc002jpc.1_RNA|SAP30BP_uc010wsf.1_RNA|SAP30BP_uc010wsg.1_RNA|SAP30BP_uc002jpf.2_Missense_Mutation_p.R110T	NM_013260	NP_037392	Q9UHR5	S30BP_HUMAN	transcriptional regulator protein	126					apoptosis|induction of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			ovary(1)	1	all_cancers(13;6.42e-08)		all cancers(21;4.25e-07)|Epithelial(20;9.57e-07)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			CCCCCTGGCAGATGTTCAAAT	0.453		NaN											0	0	0	0.01441	0	53	152									
EIF4A3	9775	broad.mit.edu	37	17	78111277	78111277	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:78111277C>T	uc010wuc.1	-	10	964	c.891G>A	c.(889-891)ATG>ATA	p.M297I	EIF4A3_uc002jxs.2_Missense_Mutation_p.M297I	NM_014740	NP_055555	P38919	IF4A3_HUMAN	eukaryotic translation initiation factor 4A,	297	Helicase C-terminal.				mRNA transport|negative regulation of translation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|rRNA processing	catalytic step 2 spliceosome|cytoplasm|exon-exon junction complex|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|poly(A) RNA binding|protein binding			ovary(1)	1	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)			TGGCTTCCCTCATTTTCTCCG	0.517		NaN											0	0	0	0.00632	0	24	24									
NDC80	10403	broad.mit.edu	37	18	2578034	2578034	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr18:2578034G>C	uc002kli.2	+	5	552	c.370G>C	c.(370-372)GAC>CAC	p.D124H		NM_006101	NP_006092	O14777	NDC80_HUMAN	kinetochore associated 2	124	Interaction with the N-terminus of CDCA1.|Nuclear localization.				attachment of spindle microtubules to kinetochore|cell division|establishment of mitotic spindle orientation|mitotic prometaphase|mitotic sister chromatid segregation|mitotic spindle organization|phosphatidylinositol-mediated signaling	condensed nuclear chromosome outer kinetochore|cytosol|Ndc80 complex	protein binding			ovary(1)	1						CTCTGTTAAAGACTTCCTGAA	0.368		NaN											0	0	0	0.006214	0	8	246									
LPIN2	9663	broad.mit.edu	37	18	2921615	2921615	+	Silent	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr18:2921615G>A	uc002klo.2	-	18	2597	c.2358C>T	c.(2356-2358)TTC>TTT	p.F786F		NM_014646	NP_055461	Q92539	LPIN2_HUMAN	lipin 2	786	C-LIP.				fatty acid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|triglyceride biosynthetic process	cytosol|endoplasmic reticulum membrane|nucleus	phosphatidate phosphatase activity|transcription coactivator activity			ovary(1)|skin(1)	2				READ - Rectum adenocarcinoma(2;0.0419)|Colorectal(6;0.156)		ACTCAATTTTGAACTTCTCTG	0.393		NaN											0	0	0	0.004482	0	8	204									
EPB41L3	23136	broad.mit.edu	37	18	5489114	5489114	+	Silent	SNP	C	C	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr18:5489114C>A	uc002kmt.1	-	2	155	c.69G>T	c.(67-69)GCG>GCT	p.A23A	EPB41L3_uc010wzh.1_Silent_p.A23A|EPB41L3_uc002kmu.1_Silent_p.A23A|EPB41L3_uc010dkq.1_5'UTR|EPB41L3_uc010dks.1_Silent_p.A45A|EPB41L3_uc002kmv.1_5'UTR	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	23					cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						cctgcgcccccgccgccTCCT	0.517		NaN											1	0	1.30293e-26	0.003271	1.397e-26	31	57									
PPP4R1	9989	broad.mit.edu	37	18	9570582	9570582	+	Silent	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr18:9570582C>T	uc002koe.1	-	11	1264	c.1146G>A	c.(1144-1146)ACG>ACA	p.T382T	PPP4R1_uc002kof.2_5'UTR|PPP4R1_uc010wzo.1_Silent_p.T228T|PPP4R1_uc002kod.1_Silent_p.T365T|PPP4R1_uc010wzp.1_RNA	NM_001042388	NP_001035847	Q8TF05	PP4R1_HUMAN	protein phosphatase 4, regulatory subunit 1	382					protein phosphorylation|signal transduction	protein phosphatase 4 complex	protein binding|protein phosphatase type 4 regulator activity			skin(1)	1						GGTCTTCCATCGTGTTTTCCA	0.478		NaN											0	0	0	0.01441	0	161	79									
AFG3L2	10939	broad.mit.edu	37	18	12367072	12367072	+	Silent	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr18:12367072G>C	uc002kqz.1	-	5	557	c.444C>G	c.(442-444)CTC>CTG	p.L148L		NM_006796	NP_006787	Q9Y4W6	AFG32_HUMAN	AFG3 ATPase family gene 3-like 2	148	Helical; (Potential).				cell death|protein catabolic process|proteolysis	integral to membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding				0					Adenosine triphosphate(DB00171)	GAGCAGTCCAGAGGAAGAACA	0.453		NaN											0	0	0	0.013537	0	11	192									
ANKRD30B	374860	broad.mit.edu	37	18	14764040	14764040	+	Silent	SNP	T	T	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr18:14764040T>C	uc010dlo.2	+	7	1356	c.1176T>C	c.(1174-1176)AAT>AAC	p.N392N	ANKRD30B_uc010xak.1_RNA	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	392										ovary(1)|skin(1)	2						GAACATCTAATATGATTGCAT	0.383		NaN											0	0	0	0.004289	0	32	9									
ZNF521	25925	broad.mit.edu	37	18	22807046	22807046	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr18:22807046G>A	uc002kvk.2	-	4	1083	c.836C>T	c.(835-837)GCG>GTG	p.A279V	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.A279V|ZNF521_uc002kvl.2_Missense_Mutation_p.A59V	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	279					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					CTGGAGGGCCGCTCGGTCCTC	0.557		NaN	T	PAX5	ALL								0	0	0	0.004672	0	3	55									
DSC3	1825	broad.mit.edu	37	18	28588292	28588292	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr18:28588292G>A	uc002kwj.3	-	10	1618	c.1463C>T	c.(1462-1464)TCA>TTA	p.S488L	DSC3_uc002kwi.3_Missense_Mutation_p.S488L	NM_001941	NP_001932	Q14574	DSC3_HUMAN	desmocollin 3 isoform Dsc3a preproprotein	488	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			ovary(2)|skin(2)	4			OV - Ovarian serous cystadenocarcinoma(10;0.125)			GTTGATCTTTGACCCCACTGC	0.403		NaN											0	0	0	0.001168	0	5	22									
DSG4	147409	broad.mit.edu	37	18	28972175	28972175	+	Missense_Mutation	SNP	A	A	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr18:28972175A>G	uc002kwq.2	+	8	1012	c.877A>G	c.(877-879)ATT>GTT	p.I293V	DSG4_uc002kwr.2_Missense_Mutation_p.I293V	NM_177986	NP_817123	Q86SJ6	DSG4_HUMAN	desmoglein 4 isoform 2 preproprotein	293	Cadherin 3.|Extracellular (Potential).		Missing (in LAH1).		homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			ATTACAAGCAATTGATCTTGA	0.343		NaN											0	0	0	0.008291	0	9	54									
MC4R	4160	broad.mit.edu	37	18	58038604	58038604	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr18:58038604C>T	uc002lie.1	-	1	1398	c.979G>A	c.(979-981)GAC>AAC	p.D327N		NM_005912	NP_005903	P32245	MC4R_HUMAN	melanocortin 4 receptor	327	Cytoplasmic (Potential).				feeding behavior|G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of bone resorption|positive regulation of cAMP biosynthetic process	integral to membrane|plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|ubiquitin protein ligase binding			lung(1)	1		Colorectal(73;0.0946)				CTAGACAAGTCACAAAGGCCT	0.418		NaN											0	0	0	0.01441	0	41	23									
ATP9B	374868	broad.mit.edu	37	18	77089190	77089190	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr18:77089190G>C	uc002lmx.2	+	16	1837	c.1823G>C	c.(1822-1824)AGG>ACG	p.R608T	ATP9B_uc002lmv.1_RNA|ATP9B_uc002lmw.1_Missense_Mutation_p.R608T|ATP9B_uc002lmz.1_Missense_Mutation_p.R302T	NM_198531	NP_940933	O43861	ATP9B_HUMAN	ATPase, class II, type 9B	608	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)	3		Esophageal squamous(42;0.018)|Melanoma(33;0.0964)|Prostate(75;0.171)		OV - Ovarian serous cystadenocarcinoma(15;1.44e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0405)		CTGGTCAGCAGGGACCTCACC	0.622		NaN											0	0	0	0.001168	0	6	16									
PIAS4	51588	broad.mit.edu	37	19	4028756	4028756	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr19:4028756G>C	uc002lzg.2	+	6	721	c.711G>C	c.(709-711)AAG>AAC	p.K237N		NM_015897	NP_056981	Q8N2W9	PIAS4_HUMAN	protein inhibitor of activated STAT, 4	237	PINIT.				positive regulation of protein sumoylation|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|PML body	DNA binding|SUMO ligase activity|ubiquitin protein ligase binding|zinc ion binding			pancreas(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGAGCCCAAGAGGCCGTGCC	0.647		NaN											0	0	0	0.006214	0	7	32									
PLIN4	729359	broad.mit.edu	37	19	4511893	4511893	+	Silent	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr19:4511893C>G	uc002mar.1	-	3	2037	c.2037G>C	c.(2035-2037)CTG>CTC	p.L679L	PLIN4_uc010dub.1_5'Flank	NM_001080400	NP_001073869	Q96Q06	PLIN4_HUMAN	plasma membrane associated protein, S3-12	679	18.|27 X 33 AA approximate tandem repeat.					lipid particle|plasma membrane					0						TGGTGCCGGTCAGCACGGTCT	0.577		NaN											0	0	0	0.00245	0	11	252									
UHRF1	29128	broad.mit.edu	37	19	4944248	4944248	+	Nonsense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr19:4944248C>G	uc002mbo.2	+	8	1346	c.1178C>G	c.(1177-1179)TCA>TGA	p.S393*	UHRF1_uc010xik.1_RNA|UHRF1_uc010duf.2_RNA|UHRF1_uc002mbp.2_Nonsense_Mutation_p.S406*	NM_001048201	NP_001041666	Q96T88	UHRF1_HUMAN	ubiquitin-like with PHD and ring finger domains	393	Methyl-CpG binding and interaction with HDAC1.				cell cycle|cell proliferation|DNA repair|regulation of transcription from RNA polymerase II promoter	nucleus	acid-amino acid ligase activity|methyl-CpG binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0276)		ACATCGTCCTCACAGCGGGAC	0.652		NaN											0	0	0	0.001168	0	4	39									
GPR108	56927	broad.mit.edu	37	19	6732095	6732095	+	Silent	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr19:6732095C>T	uc002mfp.2	-	13	1243	c.1197G>A	c.(1195-1197)AAG>AAA	p.K399K	GPR108_uc010duv.2_5'UTR|GPR108_uc002mfn.2_Silent_p.K70K|GPR108_uc002mfo.3_Silent_p.K157K|GPR108_uc010duw.2_RNA	NM_001080452	NP_001073921	Q9NPR9	GP108_HUMAN	G protein-coupled receptor 108 isoform 1	399						integral to membrane					0						ACAAAATCTCCTTCCACAGCA	0.652		NaN											0	0	0	0.001855	0	12	4									
ZNF823	55552	broad.mit.edu	37	19	11833886	11833886	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr19:11833886C>G	uc002msm.2	-	4	589	c.463G>C	c.(463-465)GAA>CAA	p.E155Q	ZNF823_uc010xmd.1_5'UTR|ZNF823_uc010dyi.1_Missense_Mutation_p.E111Q	NM_001080493	NP_001073962	P16415	ZN823_HUMAN	ZFP-36 for a zinc finger protein	155					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						GGGGGCCTTTCATGTGTCTGG	0.468		NaN								HNSCC(68;0.2)			0	0	0	0.001855	0	13	68									
ABHD8	79575	broad.mit.edu	37	19	17405223	17405223	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr19:17405223C>A	uc002ngb.3	-	4	1263	c.1023G>T	c.(1021-1023)ATG>ATT	p.M341I		NM_024527	NP_078803	Q96I13	ABHD8_HUMAN	abhydrolase domain containing 8	341							hydrolase activity				0						GGCCGCTCATCATGGCCCGGA	0.632		NaN											1	0	8.34094e-07	0.008871	8.57619e-07	18	158									
ZNF536	9745	broad.mit.edu	37	19	31039136	31039136	+	Silent	SNP	G	G	A	rs149881182	byFrequency	TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr19:31039136G>A	uc002nsu.1	+	4	2748	c.2610G>A	c.(2608-2610)TCG>TCA	p.S870S	ZNF536_uc010edd.1_Silent_p.S870S	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	870					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GAGATCACTCGGGGCAGGCCA	0.582		NaN											0	0	0	0.009535	0	31	40									
SARS2	54938	broad.mit.edu	37	19	39421292	39421292	+	Missense_Mutation	SNP	T	T	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr19:39421292T>C	uc002oka.2	-	1	245	c.85A>G	c.(85-87)AGT>GGT	p.S29G	SARS2_uc002ojz.2_5'Flank|SARS2_uc010xup.1_Missense_Mutation_p.S29G|SARS2_uc002okb.2_Missense_Mutation_p.S29G|SARS2_uc010xuq.1_Intron|SARS2_uc010xur.1_RNA|SARS2_uc010xus.1_Missense_Mutation_p.S29G|MRPS12_uc002okc.2_5'Flank|MRPS12_uc002okd.2_5'Flank|MRPS12_uc002oke.2_5'Flank	NM_017827	NP_060297	Q9NP81	SYSM_HUMAN	seryl-tRNA synthetase 2 isoform b precursor	29					seryl-tRNA aminoacylation	mitochondrial matrix	ATP binding|protein binding|serine-tRNA ligase activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(60;2.74e-06)|all_epithelial(25;4.36e-06)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			CTCCTTGGACTATCGTTGGAG	0.607		NaN									OREG0025455	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004672	0	3	88									
AXL	558	broad.mit.edu	37	19	41737167	41737167	+	Silent	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr19:41737167G>C	uc010ehj.2	+	6	937	c.747G>C	c.(745-747)CTG>CTC	p.L249L	CYP2F1_uc010xvw.1_Intron|AXL_uc010ehi.1_Silent_p.L249L|AXL_uc010ehk.2_Silent_p.L249L	NM_021913	NP_068713	P30530	UFO_HUMAN	AXL receptor tyrosine kinase isoform 1	249	Extracellular (Potential).|Fibronectin type-III 1.					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|stomach(3)|ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	13						CTCCAGGCCTGAGCGGCATCT	0.622		NaN											0	0	0	0.001168	0	4	77									
ZNF221	7638	broad.mit.edu	37	19	44470975	44470975	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr19:44470975C>G	uc002oxx.2	+	6	1649	c.1321C>G	c.(1321-1323)CAG>GAG	p.Q441E	ZNF221_uc010ejb.1_Missense_Mutation_p.Q441E|ZNF221_uc010xws.1_Missense_Mutation_p.Q441E	NM_013359	NP_037491	Q9UK13	ZN221_HUMAN	zinc finger protein 221	441	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		Prostate(69;0.0352)				ATCTTCCCATCAGAGATCCCA	0.433		NaN											0	0	0	0.008291	0	9	87									
MARK4	57787	broad.mit.edu	37	19	45805792	45805792	+	Silent	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr19:45805792C>T	uc002pbb.1	+	17	2088	c.2083C>T	c.(2083-2085)CTG>TTG	p.L695L	MARK4_uc002pba.1_3'UTR			Q96L34	MARK4_HUMAN	RecName: Full=MAP/microtubule affinity-regulating kinase 4;          EC=2.7.11.1; AltName: Full=MAP/microtubule affinity-regulating kinase-like 1;	695					microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			central_nervous_system(2)|large_intestine(1)	3		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		ACAGCCGTTCCTGCTGGCCTG	0.726		NaN											0	0	0	0.001984	0	4	6									
CD3EAP	10849	broad.mit.edu	37	19	45912513	45912513	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr19:45912513G>C	uc002pbq.1	+	3	1775	c.1287G>C	c.(1285-1287)GAG>GAC	p.E429D	PPP1R13L_uc002pbo.2_5'Flank|PPP1R13L_uc002pbp.2_5'Flank|CD3EAP_uc002pbr.1_Missense_Mutation_p.E431D	NM_012099	NP_036231	O15446	RPA34_HUMAN	CD3E antigen, epsilon polypeptide associated	429					rRNA transcription|transmembrane receptor protein tyrosine kinase signaling pathway	chromosome|RNA polymerase I transcription factor complex	DNA-directed RNA polymerase activity			large_intestine(2)|ovary(2)	4		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0251)		agaagaaagagaGAGGTCACA	0.537		NaN											0	0	0	0.010504	0	22	10									
QPCTL	54814	broad.mit.edu	37	19	46206179	46206179	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr19:46206179C>G	uc010xxr.1	+	7	1242	c.1021C>G	c.(1021-1023)CTC>GTC	p.L341V	QPCTL_uc010ekn.2_Missense_Mutation_p.L247V	NM_017659	NP_060129	Q9NXS2	QPCTL_HUMAN	glutaminyl-peptide cyclotransferase-like isoform	341					peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase|proteolysis	Golgi membrane|integral to membrane	acyltransferase activity|glutaminyl-peptide cyclotransferase activity|peptidase activity|protein binding|zinc ion binding			skin(1)	1		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0059)|GBM - Glioblastoma multiforme(486;0.0882)|Epithelial(262;0.208)		CGTGCTCCATCTCATCTCCAC	0.597		NaN											0	0	0	0.01441	0	86	125									
CARD8	22900	broad.mit.edu	37	19	48734962	48734962	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr19:48734962C>T	uc002pie.3	-	4	495	c.182G>A	c.(181-183)GGA>GAA	p.G61E	CARD8_uc002pii.3_Missense_Mutation_p.G166E|CARD8_uc010xzi.1_Missense_Mutation_p.G61E|CARD8_uc010els.2_Missense_Mutation_p.G99E|CARD8_uc010xzj.1_Missense_Mutation_p.G166E|CARD8_uc010xzk.1_Missense_Mutation_p.G85E|CARD8_uc002pif.3_Missense_Mutation_p.G61E|CARD8_uc002pig.3_5'UTR|CARD8_uc002pih.3_Missense_Mutation_p.G116E|CARD8_uc010xzl.1_Missense_Mutation_p.G116E|CARD8_uc010xzm.1_Missense_Mutation_p.G166E	NM_014959	NP_055774	Q9Y2G2	CARD8_HUMAN	caspase recruitment domain family, member 8	61					negative regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion	cytoplasm|nucleus	caspase activator activity|NACHT domain binding|protein homodimerization activity				0		all_lung(116;0.000112)|Lung NSC(112;0.000192)|all_epithelial(76;0.000349)|all_neural(266;0.0228)|Ovarian(192;0.113)|Prostate(7;0.184)		OV - Ovarian serous cystadenocarcinoma(262;0.000112)|all cancers(93;0.000293)|Epithelial(262;0.0129)|GBM - Glioblastoma multiforme(486;0.0336)		ATCCACATTTCCTTCAGGCCC	0.363		NaN											0	0	0	0.01441	0	52	55									
ZNF578	147660	broad.mit.edu	37	19	52994576	52994576	+	Splice_Site	SNP	G	G	C	rs61191258		TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr19:52994576G>C	uc002pzp.3	+	3	124	c.-120_splice	c.e3-1			NM_001099694	NP_001093164	Q96N58	ZN578_HUMAN	zinc finger protein 578						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00819)|OV - Ovarian serous cystadenocarcinoma(262;0.01)		ATATTTTGTAGATATCTCTTC	0.169		NaN											0	0	0	0.009096	0	3	2									
FCAR	2204	broad.mit.edu	37	19	55401022	55401023	+	Missense_Mutation	DNP	CC	CC	TA			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr19:55401022_55401023CC>TA	uc002qhr.1	+	5	854_855	c.657_658CC>TA	c.(655-660)ATCCAC>ATTAAC	p.H220N	FCAR_uc002qhs.1_RNA|FCAR_uc002qht.1_Missense_Mutation_p.H171N|FCAR_uc010esi.1_Missense_Mutation_p.H97N|FCAR_uc002qhu.1_Missense_Mutation_p.H124N|FCAR_uc002qhv.1_Missense_Mutation_p.H198N|FCAR_uc002qhw.1_Missense_Mutation_p.H208N|FCAR_uc002qhx.1_Missense_Mutation_p.H112N|FCAR_uc002qhy.1_Missense_Mutation_p.H186N|FCAR_uc002qhz.1_Nonsense_Mutation_p.P183*|FCAR_uc002qia.1_Missense_Mutation_p.H111N	NM_002000	NP_001991	P24071	FCAR_HUMAN	Fc alpha receptor isoform a precursor	220	Extracellular (Potential).				immune response	extracellular region|integral to plasma membrane	IgA binding|receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(193;0.0443)		CAGACTCCATCCACCAAGATTA	0.515		NaN											0	0	0	0.004672	0	52	606									
C19orf51	352909	broad.mit.edu	37	19	55677318	55677318	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr19:55677318C>T	uc002qji.1	-	3	170	c.136G>A	c.(136-138)GAG>AAG	p.E46K	C19orf51_uc002qjj.1_Missense_Mutation_p.E93K|C19orf51_uc002qjk.1_5'UTR|C19orf51_uc002qjl.1_Missense_Mutation_p.E114K			Q8N9W5	CS051_HUMAN	RecName: Full=UPF0470 protein C19orf51;	46											0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		ACATCTAGCTCGGGGTTGCTG	0.632		NaN									OREG0025679	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.005524	0	34	36									
ZNF667	63934	broad.mit.edu	37	19	56953734	56953734	+	Missense_Mutation	SNP	A	A	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr19:56953734A>T	uc002qnd.2	-	5	792	c.630T>A	c.(628-630)AAT>AAA	p.N210K	ZNF667_uc010etl.2_5'UTR|ZNF667_uc002qne.2_Missense_Mutation_p.N210K|ZNF667_uc010etm.2_Missense_Mutation_p.N153K	NM_022103	NP_071386	Q5HYK9	ZN667_HUMAN	zinc finger protein 667	210	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		TTGTTCTTTGATTGAAGCTTT	0.378		NaN											0	0	0	0.007413	0	17	152									
SLC27A5	10998	broad.mit.edu	37	19	59011880	59011880	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr19:59011880C>T	uc002qtc.2	-	5	1486	c.1376G>A	c.(1375-1377)CGA>CAA	p.R459Q	SLC27A5_uc002qtb.2_5'Flank	NM_012254	NP_036386	Q9Y2P5	S27A5_HUMAN	solute carrier family 27 (fatty acid	459	Cytoplasmic (Probable).				bile acid and bile salt transport|bile acid biosynthetic process|very long-chain fatty acid metabolic process	endoplasmic reticulum membrane|integral to membrane	ATP binding|cholate-CoA ligase activity|long-chain fatty acid-CoA ligase activity				0		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.181)		CACACTCACTCGGAGGAGGCA	0.607		NaN											0	0	0	0.000602	0	4	31									
CCDC88A	55704	broad.mit.edu	37	2	55563882	55563882	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr2:55563882G>C	uc002ryv.2	-	14	2433	c.1591C>G	c.(1591-1593)CTA>GTA	p.L531V	CCDC88A_uc010yoz.1_Missense_Mutation_p.L531V|CCDC88A_uc010ypa.1_Missense_Mutation_p.L531V|CCDC88A_uc010ypb.1_Missense_Mutation_p.L433V|CCDC88A_uc002ryu.2_5'Flank|CCDC88A_uc002ryw.2_5'Flank	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	531	Potential.				activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						TCCTTCATTAGATCCTTGCTT	0.299		NaN											0	0	0	0.010729	0	11	90									
KCNIP3	30818	broad.mit.edu	37	2	96048223	96048223	+	Silent	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr2:96048223C>T	uc002sup.2	+	7	769	c.654C>T	c.(652-654)TTC>TTT	p.F218F	KCNIP3_uc002suq.2_Silent_p.F192F	NM_013434	NP_038462	Q9Y2W7	CSEN_HUMAN	Kv channel interacting protein 3 isoform 1	218	EF-hand 4.				apoptosis|signal transduction|transcription, DNA-dependent	endoplasmic reticulum|Golgi apparatus|nucleus|plasma membrane	calcium ion binding|DNA binding|potassium channel activity|transcription corepressor activity|voltage-gated ion channel activity			breast(2)|ovary(1)	3				READ - Rectum adenocarcinoma(193;0.13)		TGGAGAGGTTCTTCGAGGTGA	0.657		NaN											0	0	0	0.012213	0	25	24									
PSD4	23550	broad.mit.edu	37	2	113940993	113940993	+	Silent	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr2:113940993C>T	uc002tjc.2	+	2	1143	c.960C>T	c.(958-960)TTC>TTT	p.F320F	PSD4_uc002tjd.2_5'UTR|PSD4_uc002tje.2_Silent_p.F319F|PSD4_uc002tjf.2_5'Flank	NM_012455	NP_036587	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	320					regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						CCCCTCCATTCCCTGTGCCCA	0.607		NaN											0	0	0	0.000602	0	4	84									
PLA2R1	22925	broad.mit.edu	37	2	160833209	160833209	+	Silent	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr2:160833209G>A	uc002ube.1	-	16	2631	c.2424C>T	c.(2422-2424)TTC>TTT	p.F808F	PLA2R1_uc010zcp.1_Silent_p.F808F|PLA2R1_uc002ubf.2_Silent_p.F808F	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	808	Extracellular (Potential).				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						ACTGGTACCAGAACGGAATCT	0.353		NaN											0	0	0	0.006214	0	6	92									
PLA2R1	22925	broad.mit.edu	37	2	160840459	160840459	+	Silent	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr2:160840459G>C	uc002ube.1	-	13	2370	c.2163C>G	c.(2161-2163)CTC>CTG	p.L721L	PLA2R1_uc010zcp.1_Silent_p.L721L|PLA2R1_uc002ubf.2_Silent_p.L721L	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	721	Extracellular (Potential).|C-type lectin 4.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						TTGAATGTAAGAGCTCATTCA	0.353		NaN											0	0	0	0.009096	0	4	63									
SCN9A	6335	broad.mit.edu	37	2	167159806	167159806	+	Missense_Mutation	SNP	T	T	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr2:167159806T>G	uc010fpl.2	-	7	1036	c.695A>C	c.(694-696)AAG>ACG	p.K232T	SCN9A_uc002udr.1_Missense_Mutation_p.K103T|SCN9A_uc002uds.1_Missense_Mutation_p.K103T|SCN9A_uc002udt.1_Missense_Mutation_p.K103T	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	232	I.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	TACAATTGTCTTCAGGCCTGA	0.393		NaN											0	0	0	0.004289	0	32	34									
NOSTRIN	115677	broad.mit.edu	37	2	169681198	169681198	+	Silent	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr2:169681198G>A	uc002ueg.2	+	3	172	c.168G>A	c.(166-168)CTG>CTA	p.L56L	NOSTRIN_uc002uef.2_Silent_p.L56L|NOSTRIN_uc002uei.2_5'UTR|NOSTRIN_uc010fpu.2_Intron|NOSTRIN_uc002ueh.2_5'UTR|NOSTRIN_uc002uej.2_5'UTR	NM_001039724	NP_001034813	Q8IVI9	NOSTN_HUMAN	nitric oxide synthase trafficker isoform 2	56	FCH.				endocytosis|nitric oxide metabolic process|regulation of nitric-oxide synthase activity	cytoplasmic membrane-bounded vesicle|cytoskeleton|plasma membrane	protein binding				0						CAAGCAAGCTGAGCAAAGCAT	0.323		NaN											0	0	0	0.006214	0	8	88									
DFNB59	494513	broad.mit.edu	37	2	179319144	179319144	+	Silent	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr2:179319144C>T	uc002umi.3	+	3	653	c.297C>T	c.(295-297)GAC>GAT	p.D99D	DFNB59_uc002umj.3_Silent_p.D99D	NM_001042702	NP_001036167	Q0ZLH3	PJVK_HUMAN	deafness, autosomal recessive 59	99					sensory perception of sound						0			OV - Ovarian serous cystadenocarcinoma(117;0.00406)|Epithelial(96;0.0159)|all cancers(119;0.0564)			TTGTAAATGACGTTGGGATTA	0.338		NaN											0	0	0	0.00308	0	6	119									
TTN	7273	broad.mit.edu	37	2	179438342	179438342	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr2:179438342C>G	uc010zfg.1	-	275	65037	c.64813G>C	c.(64813-64815)GTA>CTA	p.V21605L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V15300L|TTN_uc010zfi.1_Missense_Mutation_p.V15233L|TTN_uc010zfj.1_Missense_Mutation_p.V15108L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22532							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTGAGGCTACATTTGTCCAT	0.413		NaN											0	0	0	0.001855	0	11	398									
TTN	7273	broad.mit.edu	37	2	179588019	179588019	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr2:179588019G>T	uc010zfg.1	-	72	18207	c.17983C>A	c.(17983-17985)CAT>AAT	p.H5995N	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.H2656N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6922							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTACAGAATGATCACTTAAT	0.388		NaN											1	0	9.16793e-09	0.00499	9.5738e-09	14	36									
TTN	7273	broad.mit.edu	37	2	179612864	179612864	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr2:179612864G>C	uc002unb.2	-	46	14487	c.14263C>G	c.(14263-14265)CTA>GTA	p.L4755V	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCATTTTCTAGAGGACAACTT	0.388		NaN											0	0	0	0.00333	0	17	28									
MFSD6	54842	broad.mit.edu	37	2	191362263	191362263	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr2:191362263C>G	uc002urz.2	+	7	2314	c.1990C>G	c.(1990-1992)CGC>GGC	p.R664G	MFSD6_uc010zge.1_Missense_Mutation_p.R126G	NM_017694	NP_060164	Q6ZSS7	MFSD6_HUMAN	major facilitator superfamily domain containing	664					transmembrane transport	integral to membrane				ovary(2)	2						TGTCATGCCACGCATTGAGCC	0.502		NaN											0	0	0	0.003163	0	12	145									
SDPR	8436	broad.mit.edu	37	2	192701216	192701216	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr2:192701216C>G	uc002utb.2	-	2	1041	c.711G>C	c.(709-711)AAG>AAC	p.K237N		NM_004657	NP_004648	O95810	SDPR_HUMAN	serum deprivation response protein	237	Potential.					caveola|cytosol	phosphatidylserine binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	TATCCACTTTCTTCAGGCTGG	0.463		NaN											0	0	0	0.006122	0	18	226									
HSPD1	3329	broad.mit.edu	37	2	198358053	198358053	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr2:198358053C>G	uc002uui.2	-	7	1001	c.864G>C	c.(862-864)TTG>TTC	p.L288F	HSPD1_uc002uuj.2_Missense_Mutation_p.L286F|HSPD1_uc010zgx.1_Missense_Mutation_p.L279F|HSPD1_uc010fsm.2_Missense_Mutation_p.L99F|HSPD1_uc002uuk.2_Missense_Mutation_p.L288F	NM_002156	NP_002147	P10809	CH60_HUMAN	chaperonin	288					'de novo' protein folding|activation of caspase activity|B cell cytokine production|B cell proliferation|chaperone-mediated protein complex assembly|interspecies interaction between organisms|isotype switching to IgG isotypes|MyD88-dependent toll-like receptor signaling pathway|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of interferon-alpha production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of macrophage activation|positive regulation of T cell activation|positive regulation of T cell mediated immune response to tumor cell|protein maturation|protein refolding|protein stabilization|response to unfolded protein|T cell activation	cell surface|coated pit|coated vesicle|cytosol|early endosome|extracellular space|lipopolysaccharide receptor complex|mitochondrial inner membrane|mitochondrial matrix|stored secretory granule	ATP binding|ATPase activity|cell surface binding|chaperone binding|DNA replication origin binding|lipopolysaccharide binding|p53 binding|single-stranded DNA binding				0			Epithelial(96;0.225)			ATTACCTATTCAAGACGAGTG	0.393		NaN											0	0	0	0.00499	0	13	184									
NOP58	51602	broad.mit.edu	37	2	203164980	203164980	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr2:203164980C>G	uc002uzb.2	+	13	1442	c.1292C>G	c.(1291-1293)TCT>TGT	p.S431C		NM_015934	NP_057018	Q9Y2X3	NOP58_HUMAN	NOP58 ribonucleoprotein homolog	431					cell growth|rRNA processing|snRNP protein import into nucleus	box C/D snoRNP complex|Cajal body|cytoplasm|pre-snoRNP complex	protein binding|snoRNA binding				0						TACGATCCTTCTGGTGACTCC	0.333		NaN											0	0	0	0.010729	0	11	89									
PLEKHM3	389072	broad.mit.edu	37	2	208795681	208795681	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr2:208795681G>A	uc002vcl.2	-	5	2345	c.1855C>T	c.(1855-1857)CGG>TGG	p.R619W	PLEKHM3_uc002vcm.2_Missense_Mutation_p.R619W	NM_001080475	NP_001073944	Q6ZWE6	PKHM3_HUMAN	pleckstrin homology domain containing, family M,	619					intracellular signal transduction		metal ion binding			ovary(1)	1						ACCGCTGCCCGGCAGCTGAAC	0.622		NaN											0	0	0	0.001168	0	5	99									
ZNF142	7701	broad.mit.edu	37	2	219508869	219508869	+	Silent	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr2:219508869C>T	uc002vin.2	-	8	2806	c.2370G>A	c.(2368-2370)GAG>GAA	p.E790E	ZNF142_uc002vil.2_Silent_p.E751E|ZNF142_uc010fvt.2_Silent_p.E627E|ZNF142_uc002vim.2_Silent_p.E627E	NM_001105537	NP_001099007	P52746	ZN142_HUMAN	zinc finger protein 142	790					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		AGGGTGCTGTCTCAGCAGGTG	0.532		NaN											0	0	0	0.008291	0	6	198									
CYP27A1	1593	broad.mit.edu	37	2	219679356	219679356	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr2:219679356G>C	uc002viz.3	+	8	1786	c.1352G>C	c.(1351-1353)AGA>ACA	p.R451T		NM_000784	NP_000775	Q02318	CP27A_HUMAN	cytochrome P450, family 27, subfamily A,	451					bile acid biosynthetic process|xenobiotic metabolic process	mitochondrial matrix	cholestanetriol 26-monooxygenase activity|electron carrier activity|heme binding			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;9.48e-07)|all cancers(144;0.000171)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00981)	Cholecalciferol(DB00169)	CGCTGGCTGAGAAACAGCCAG	0.607		NaN											0	0	0	0.001984	0	6	60									
ANKZF1	55139	broad.mit.edu	37	2	220100580	220100580	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr2:220100580C>T	uc002vkg.2	+	12	2128	c.1954C>T	c.(1954-1956)CTC>TTC	p.L652F	ANKZF1_uc002vkh.2_Missense_Mutation_p.L442F|ANKZF1_uc002vki.2_Missense_Mutation_p.L652F	NM_018089	NP_060559	Q9H8Y5	ANKZ1_HUMAN	ankyrin repeat and zinc finger domain containing	652	Potential.					intracellular	zinc ion binding			ovary(2)	2		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ATTTGCCGCCCTCAGTGACCG	0.622		NaN											0	0	0	0.01441	0	46	93									
ZCCHC3	85364	broad.mit.edu	37	20	279194	279194	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr20:279194G>A	uc002wdf.2	+	2	988	c.964G>A	c.(964-966)GAG>AAG	p.E322K	ZCCHC3_uc002wdg.2_RNA	NM_033089	NP_149080	Q9NUD5	ZCHC3_HUMAN	zinc finger, CCHC domain containing 3	323							nucleic acid binding|zinc ion binding				0		all_cancers(10;0.000209)|Lung NSC(37;0.0417)|all_lung(30;0.0713)|all_epithelial(17;0.0748)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.149)			CCTGGGGGCCGAGAGGGGCTA	0.632		NaN											0	0	0	0.00874	0	43	64									
ZCCHC3	85364	broad.mit.edu	37	20	279302	279302	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr20:279302G>A	uc002wdf.2	+	2	1096	c.1072G>A	c.(1072-1074)GAG>AAG	p.E358K	ZCCHC3_uc002wdg.2_RNA	NM_033089	NP_149080	Q9NUD5	ZCHC3_HUMAN	zinc finger, CCHC domain containing 3	359	CCHC-type 2.						nucleic acid binding|zinc ion binding				0		all_cancers(10;0.000209)|Lung NSC(37;0.0417)|all_lung(30;0.0713)|all_epithelial(17;0.0748)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.149)			CAGGTGCGGGGAGGAGGGGCA	0.607		NaN											0	0	0	0.01441	0	54	77									
CD93	22918	broad.mit.edu	37	20	23065965	23065965	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr20:23065965G>T	uc002wsv.2	-	1	1013	c.865C>A	c.(865-867)CCA>ACA	p.P289T		NM_012072	NP_036204	Q9NPY3	C1QR1_HUMAN	CD93 antigen precursor	289	EGF-like 1.|Extracellular (Potential).				cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			large_intestine(2)	2	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					CGGAATCCTGGTCGGCAGCCG	0.637		NaN											1	0	8.34094e-07	0.008871	8.57619e-07	18	258									
MYLK2	85366	broad.mit.edu	37	20	30412081	30412081	+	Missense_Mutation	SNP	T	T	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr20:30412081T>A	uc002wwq.2	+	6	1000	c.898T>A	c.(898-900)TGT>AGT	p.C300S	MYLK2_uc002wws.2_5'Flank	NM_033118	NP_149109	Q9H1R3	MYLK2_HUMAN	skeletal myosin light chain kinase	300	Protein kinase.				cardiac muscle tissue morphogenesis|regulation of muscle filament sliding		ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			lung(2)|skin(2)|ovary(1)|central_nervous_system(1)	6			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			TGGGGCAGTCTGTACCTGCAT	0.562		NaN											0	0	0	0.007291	0	23	41									
EMILIN3	90187	broad.mit.edu	37	20	39990291	39990291	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr20:39990291G>C	uc002xjy.1	-	4	2142	c.1918C>G	c.(1918-1920)CAA>GAA	p.Q640E		NM_052846	NP_443078	Q9NT22	EMIL3_HUMAN	elastin microfibril interfacer 3	640	Potential.					proteinaceous extracellular matrix				ovary(1)	1		Myeloproliferative disorder(115;0.00425)				CTGGAGCCTTGGCTGCTGACC	0.632		NaN											0	0	0	0.009096	0	3	34									
LAMA5	3911	broad.mit.edu	37	20	60909254	60909254	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr20:60909254C>T	uc002ycq.2	-	22	2794	c.2727G>A	c.(2725-2727)ATG>ATA	p.M909I		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	909	Domain IV 1 (domain IV B).				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGACAGGTGCCATCTGCGCGT	0.672		NaN											0	0	0	0.007835	0	32	21									
DIDO1	11083	broad.mit.edu	37	20	61512799	61512799	+	Silent	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr20:61512799C>T	uc002ydr.1	-	16	4773	c.4509G>A	c.(4507-4509)CAG>CAA	p.Q1503Q	DIDO1_uc002yds.1_Silent_p.Q1503Q	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1503					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					CGGCGGCCCTCTGCTGCCTGA	0.587		NaN											0	0	0	0.01441	0	67	142									
KCNQ2	3785	broad.mit.edu	37	20	62038153	62038153	+	Nonsense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr20:62038153G>C	uc002yey.1	-	17	2640	c.2463C>G	c.(2461-2463)TAC>TAG	p.Y821*	KCNQ2_uc002yez.1_Nonsense_Mutation_p.Y790*|KCNQ2_uc002yfa.1_Nonsense_Mutation_p.Y803*|KCNQ2_uc002yfb.1_Nonsense_Mutation_p.Y793*	NM_172107	NP_742105	O43526	KCNQ2_HUMAN	potassium voltage-gated channel KQT-like protein	821	Cytoplasmic (Potential).				axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)	CCACGGCCGCGTAGCAGCTGT	0.642		NaN											0	0	0	0.010504	0	15	10									
EEF1A2	1917	broad.mit.edu	37	20	62120282	62120282	+	Missense_Mutation	SNP	T	T	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr20:62120282T>G	uc002yfd.1	-	6	1354	c.1253A>C	c.(1252-1254)TAC>TCC	p.Y418S	EEF1A2_uc002yfe.1_Missense_Mutation_p.Y418S|EEF1A2_uc010gkg.1_Intron	NM_001958	NP_001949	Q05639	EF1A2_HUMAN	eukaryotic translation elongation factor 1 alpha	418						nucleus	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0	all_cancers(38;9.45e-12)		BRCA - Breast invasive adenocarcinoma(10;1.22e-05)			GAGAGGCGGGTACTGGGAGAA	0.667		NaN											0	0	0	0.010504	0	9	32									
TPTE	7179	broad.mit.edu	37	21	10951278	10951278	+	Missense_Mutation	SNP	A	A	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr21:10951278A>G	uc002yip.1	-	10	802	c.434T>C	c.(433-435)GTA>GCA	p.V145A	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.V127A|TPTE_uc002yir.1_Missense_Mutation_p.V107A|TPTE_uc010gkv.1_Missense_Mutation_p.V7A	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	145	Helical; (Potential).				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TTCTACAAATACTCGAAGAAG	0.244		NaN											0	0	0	0.001855	0	11	124									
UBASH3A	53347	broad.mit.edu	37	21	43838515	43838515	+	Silent	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr21:43838515G>A	uc002zbe.2	+	7	879	c.843G>A	c.(841-843)CTG>CTA	p.L281L	UBASH3A_uc002zbf.2_Silent_p.L243L|UBASH3A_uc010gpc.2_RNA|UBASH3A_uc010gpd.2_RNA|UBASH3A_uc010gpe.2_Silent_p.L243L	NM_018961	NP_061834	P57075	UBS3A_HUMAN	ubiquitin associated and SH3 domain containing,	281	SH3.					cytosol|nucleus				ovary(3)	3						TCTAGACCCTGAGAGCCCTAT	0.522		NaN											0	0	0	0.013537	0	11	199									
UPB1	51733	broad.mit.edu	37	22	24906761	24906761	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr22:24906761G>C	uc003aaf.2	+	4	530	c.409G>C	c.(409-411)GAA>CAA	p.E137Q	UPB1_uc003aae.2_Missense_Mutation_p.E69Q|UPB1_uc011ajt.1_Missense_Mutation_p.E137Q	NM_016327	NP_057411	Q9UBR1	BUP1_HUMAN	beta-ureidopropionase	137	CN hydrolase.				pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	beta-ureidopropionase activity|metal ion binding			ovary(2)	2	Colorectal(2;0.0339)					TCCTTGGACAGAATTTGCTGA	0.502		NaN											0	0	0	0.014323	0	17	55									
SYN3	8224	broad.mit.edu	37	22	33402582	33402582	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr22:33402582C>T	uc003amx.2	-	1	225	c.66G>A	c.(64-66)ATG>ATA	p.M22I	SYN3_uc003amy.2_Missense_Mutation_p.M22I|SYN3_uc003amz.2_Missense_Mutation_p.M22I	NM_003490	NP_003481	O14994	SYN3_HUMAN	synapsin III isoform IIIa	22	A.				neurotransmitter secretion	cell junction|synaptic vesicle membrane	ATP binding|ligase activity			skin(1)	1						GCAGGTCCGTCATATAGCCAT	0.607		NaN									OREG0003521	type=REGULATORY REGION|Gene=SYN3|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	0	0	0	0.01441	0	74	19									
MYH9	4627	broad.mit.edu	37	22	36695028	36695028	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr22:36695028C>A	uc003apg.2	-	24	3268	c.3037G>T	c.(3037-3039)GAG>TAG	p.E1013*		NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	1013	Potential.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						TTAGATTTCTCCTCCTCTTCT	0.527		NaN	T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				1	0	3.61183e-13	0.01441	3.84176e-13	44	14									
MYH9	4627	broad.mit.edu	37	22	36695058	36695058	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr22:36695058C>T	uc003apg.2	-	24	3238	c.3007G>A	c.(3007-3009)GAG>AAG	p.E1003K		NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	1003	Potential.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						GTGGTGAACTCAGCTATTCTG	0.498		NaN	T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				0	0	0	0.01441	0	60	18									
MYH9	4627	broad.mit.edu	37	22	36697638	36697638	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr22:36697638C>G	uc003apg.2	-	21	2804	c.2573G>C	c.(2572-2574)AGA>ACA	p.R858T	MYH9_uc003aph.1_Missense_Mutation_p.R722T	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	858	Potential.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						CTGCTTCTCTCTGACCTTCAC	0.617		NaN	T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated		OREG0026520	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.005443	0	26	11									
MYH9	4627	broad.mit.edu	37	22	36700183	36700183	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr22:36700183C>G	uc003apg.2	-	19	2479	c.2248G>C	c.(2248-2250)GAC>CAC	p.D750H	MYH9_uc003aph.1_Missense_Mutation_p.D614H	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	750	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						AGATTGCTGTCGAGCTCCAGG	0.597		NaN	T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				0	0	0	0.010771	0	34	7									
GTPBP1	9567	broad.mit.edu	37	22	39104929	39104929	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr22:39104929G>A	uc003awg.2	+	2	426	c.272G>A	c.(271-273)GGA>GAA	p.G91E		NM_004286	NP_004277	O00178	GTPB1_HUMAN	GTP binding protein 1	91					immune response|positive regulation of mRNA catabolic process|signal transduction	cytoplasmic exosome (RNase complex)|cytosol	GTP binding|GTPase activity			ovary(1)	1	Melanoma(58;0.04)					GAGGGATGCGGAGAGACCATA	0.393		NaN											0	0	0	0.01441	0	41	16									
EP300	2033	broad.mit.edu	37	22	41568628	41568628	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr22:41568628G>C	uc003azl.3	+	28	4973	c.4578G>C	c.(4576-4578)GAG>GAC	p.E1526D		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1526	Poly-Glu.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						AGGAAGAAGAGAGAAAACGAG	0.388		NaN	T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				0	0	0	0.004482	0	7	26									
CYP2D6	1565	broad.mit.edu	37	22	42523483	42523483	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr22:42523483C>T	uc003bce.2	-	7	1229	c.1139G>A	c.(1138-1140)CGT>CAT	p.R380H	uc003bcd.1_Intron|CYP2D6_uc010gyu.2_Missense_Mutation_p.R74H|CYP2D6_uc003bcf.2_Missense_Mutation_p.R329H	NM_000106	NP_000097	Q6NWU0	Q6NWU0_HUMAN	cytochrome P450, family 2, subfamily D,	380							electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen			breast(1)|skin(1)	2						TTCGATGTCACGGGATGTCAT	0.612		NaN											0	0	0	0.009096	0	3	32									
IRAK2	3656	broad.mit.edu	37	3	10254974	10254974	+	Silent	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:10254974C>G	uc003bve.1	+	5	688	c.612C>G	c.(610-612)GTC>GTG	p.V204V		NM_001570	NP_001561	O43187	IRAK2_HUMAN	interleukin-1 receptor-associated kinase 2	204					activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|endosome membrane|plasma membrane	ATP binding|NF-kappaB-inducing kinase activity|protein heterodimerization activity|protein homodimerization activity			lung(5)|breast(3)	8						CAGACGTGGTCCAGGCAACCG	0.527		NaN											0	0	0	0.003163	0	14	66									
TATDN2	9797	broad.mit.edu	37	3	10301923	10301923	+	Missense_Mutation	SNP	A	A	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:10301923A>G	uc003bvg.2	+	3	1098	c.517A>G	c.(517-519)AGG>GGG	p.R173G	TATDN2_uc003bvf.2_Missense_Mutation_p.R173G|TATDN2_uc011atr.1_Missense_Mutation_p.R173G|TATDN2_uc011ats.1_RNA|TATDN2_uc011att.1_RNA	NM_014760	NP_055575	Q93075	TATD2_HUMAN	TatD DNase domain containing 2	173						nucleus	endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding			pancreas(2)	2						GGTCCAGAAAAGGAAGAGGGA	0.473		NaN											0	0	0	0.01441	0	47	41									
NUP210	23225	broad.mit.edu	37	3	13381432	13381432	+	Silent	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:13381432G>A	uc003bxv.1	-	25	3476	c.3393C>T	c.(3391-3393)CTC>CTT	p.L1131L		NM_024923	NP_079199	Q8TEM1	PO210_HUMAN	nucleoporin 210 precursor	1131	Lumenal (Probable).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				ovary(3)|large_intestine(3)|skin(3)|pancreas(1)|liver(1)	11	all_neural(104;0.187)					TCCCGATGGCGAGGCCCTGTA	0.493		NaN											0	0	0	0.01441	0	79	109									
RFTN1	23180	broad.mit.edu	37	3	16475483	16475483	+	Silent	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:16475483G>A	uc003cay.2	-	3	489	c.207C>T	c.(205-207)CTC>CTT	p.L69L	RFTN1_uc010hes.2_Silent_p.L33L	NM_015150	NP_055965	Q14699	RFTN1_HUMAN	raft-linking protein	69						plasma membrane				ovary(3)|central_nervous_system(1)	4						ACAGCTCCAGGAGCTGGGCGG	0.652		NaN											0	0	0	0.00333	0	23	30									
TRANK1	9881	broad.mit.edu	37	3	36874032	36874032	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:36874032C>G	uc003cgj.2	-	12	5562	c.5260G>C	c.(5260-5262)GAA>CAA	p.E1754Q		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	2304	Potential.				DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						AGCAGCTTTTCAAACTCCTCC	0.522		NaN											0	0	0	0.003755	0	35	33									
SCN11A	11280	broad.mit.edu	37	3	38988357	38988357	+	Silent	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:38988357G>A	uc011ays.1	-	2	508	c.309C>T	c.(307-309)TTC>TTT	p.F103F		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	103					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	GCTTGGCACTGAAGCGGTAGA	0.363		NaN											0	0	0	0.009535	0	26	56									
TGM4	7047	broad.mit.edu	37	3	44926861	44926861	+	Missense_Mutation	SNP	G	G	A	rs141141838		TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:44926861G>A	uc003coc.3	+	2	137	c.64G>A	c.(64-66)GTT>ATT	p.V22I	TGM4_uc003coa.2_Missense_Mutation_p.V22I|TGM4_uc003cob.2_RNA	NM_003241	NP_003232	P49221	TGM4_HUMAN	transglutaminase 4 (prostate)	22					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	GGACAACGCCGTTTCTCACCA	0.517		NaN											0	0	0	0.004007	0	12	32									
ITIH4	3700	broad.mit.edu	37	3	52859944	52859944	+	Silent	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:52859944G>A	uc003dfz.2	-	6	753	c.717C>T	c.(715-717)ATC>ATT	p.I239I	ITIH4_uc011bel.1_5'UTR|ITIH4_uc003dfy.2_Silent_p.I103I|ITIH4_uc011bem.1_Silent_p.I239I|ITIH4_uc011ben.1_Silent_p.I239I	NM_002218	NP_002209	Q14624	ITIH4_HUMAN	inter-alpha (globulin) inhibitor H4	239					acute-phase response|hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		CATCATAGCGGATAATGAGGT	0.572		NaN											0	0	0	0.008291	0	8	81									
EPHA3	2042	broad.mit.edu	37	3	89259649	89259649	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:89259649G>A	uc003dqy.2	+	3	1018	c.793G>A	c.(793-795)GAA>AAA	p.E265K	EPHA3_uc003dqx.1_Missense_Mutation_p.E265K|EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	265	Extracellular (Potential).|Cys-rich.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		TGGCTATGAAGAAAGAGGTTT	0.403		NaN								TSP Lung(6;0.00050)			0	0	0	0.01441	0	112	147									
RPL24	6152	broad.mit.edu	37	3	101404687	101404687	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:101404687C>G	uc003dvh.1	-	3	210	c.167G>C	c.(166-168)AGA>ACA	p.R56T	RPL24_uc003dvi.1_Missense_Mutation_p.R56T	NM_000986	NP_000977	P83731	RL24_HUMAN	ribosomal protein L24	56					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0						GTGCTTCCTTCTGTAGAGGAC	0.458		NaN											0	0	0	0.01441	0	44	49									
CBLB	868	broad.mit.edu	37	3	105377987	105377987	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:105377987C>T	uc003dwc.2	-	19	3098	c.2776G>A	c.(2776-2778)GAG>AAG	p.E926K	CBLB_uc003dwa.2_Missense_Mutation_p.E141K|CBLB_uc011bhi.1_Missense_Mutation_p.E904K	NM_170662	NP_733762	Q13191	CBLB_HUMAN	Cas-Br-M (murine) ecotropic retroviral	926	Interaction with SH3KBP1.				cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			lung(4)|ovary(3)|breast(1)|skin(1)	9						AATGCCGCCTCAGGCCCATGG	0.493		NaN	Mis S		AML								0	0	0	0.006214	0	9	115									
KALRN	8997	broad.mit.edu	37	3	124048774	124048774	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:124048774G>T	uc003ehg.2	+	8	1472	c.1345G>T	c.(1345-1347)GAC>TAC	p.D449Y	KALRN_uc010hrv.1_Missense_Mutation_p.D449Y|KALRN_uc003ehf.1_Missense_Mutation_p.D449Y|KALRN_uc011bjy.1_Missense_Mutation_p.D449Y	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	449					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						CGAGATGCAAGACCTAGAGCT	0.572		NaN											1	0	0.00074312	0.006122	0.000756323	15	117									
COPG	22820	broad.mit.edu	37	3	128973917	128973917	+	Silent	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:128973917C>T	uc003els.2	+	7	589	c.489C>T	c.(487-489)TCC>TCT	p.S163S	COPG_uc010htb.2_Silent_p.S69S	NM_016128	NP_057212	Q9Y678	COPG_HUMAN	coatomer protein complex, subunit gamma 1	163					COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			ovary(3)|breast(1)	4						TCGTGTCTTCCTTGGTGTGTA	0.483		NaN											0	0	0	0.008871	0	17	33									
ACAD11	84129	broad.mit.edu	37	3	132347277	132347277	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:132347277C>G	uc003eov.3	-	8	1357	c.977G>C	c.(976-978)AGA>ACA	p.R326T	ACAD11_uc011blr.1_5'Flank|ACAD11_uc003eoy.2_Missense_Mutation_p.R326T	NM_032169	NP_115545	Q709F0	ACD11_HUMAN	putative acyl-CoA dehydrogenase	326						peroxisome	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|transferase activity, transferring phosphorus-containing groups			ovary(1)	1						CAGAAGATATCTGCTATATAC	0.348		NaN											0	0	0	0.004482	0	7	96									
TOPBP1	11073	broad.mit.edu	37	3	133362970	133362970	+	Missense_Mutation	SNP	T	T	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:133362970T>C	uc003eps.2	-	11	1874	c.1742A>G	c.(1741-1743)AAA>AGA	p.K581R		NM_007027	NP_008958	Q92547	TOPB1_HUMAN	topoisomerase (DNA) II binding protein 1	581	BRCT 4.				DNA repair|response to ionizing radiation	microtubule organizing center|PML body|spindle pole	DNA binding|protein C-terminus binding			ovary(2)|kidney(2)|skin(1)|lung(1)|pancreas(1)	7						GGACATGATTTTCCCAGCATT	0.403		NaN						Other_conserved_DNA_damage_response_genes					0	0	0	0.006999	0	38	48									
WDR49	151790	broad.mit.edu	37	3	167248966	167248966	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:167248966C>T	uc003fev.1	-	9	1405	c.1099G>A	c.(1099-1101)GAG>AAG	p.E367K	WDR49_uc003feu.1_Missense_Mutation_p.E192K|WDR49_uc011bpd.1_Missense_Mutation_p.E431K|WDR49_uc003few.1_Intron	NM_178824	NP_849146	Q8IV35	WDR49_HUMAN	WD repeat domain 49	367	WD 6.									large_intestine(1)|ovary(1)|skin(1)	3						TTTTTGCCCTCAGTGTCAATC	0.408		NaN											0	0	0	0.001168	0	6	112									
TNFSF10	8743	broad.mit.edu	37	3	172229441	172229441	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:172229441C>G	uc003fid.2	-	3	374	c.279G>C	c.(277-279)TTG>TTC	p.L93F	TNFSF10_uc003fie.2_Intron	NM_003810	NP_003801	P50591	TNF10_HUMAN	tumor necrosis factor (ligand) superfamily,	93	Extracellular (Potential).				activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of apoptosis by extracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane|soluble fraction	cytokine activity|metal ion binding|tumor necrosis factor receptor binding			skin(4)|lung(1)	5	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.67e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			CAGAGGTTCTCAAAATCATCT	0.313		NaN											0	0	0	0.007291	0	22	14									
PIK3CA	5290	broad.mit.edu	37	3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	rs104886003		TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			0	0	0	0.004878	0	30	50									
CHRD	8646	broad.mit.edu	37	3	184104518	184104518	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:184104518C>T	uc003fov.2	+	16	2417	c.2171C>T	c.(2170-2172)CCG>CTG	p.P724L	CHRD_uc003fow.2_Missense_Mutation_p.P354L|CHRD_uc003fox.2_Missense_Mutation_p.P724L|CHRD_uc003foy.2_Missense_Mutation_p.P354L|CHRD_uc010hyc.2_Missense_Mutation_p.P314L|CHRD_uc011brr.1_Intron	NM_003741	NP_003732	Q9H2X0	CHRD_HUMAN	chordin precursor	724	VWFC 2.				BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			skin(2)|ovary(1)	3	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AACTACGACCCGCTCTGCTCA	0.672		NaN											0	0	0	0.013537	0	12	16									
DGKG	1608	broad.mit.edu	37	3	185985533	185985533	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:185985533C>T	uc003fqa.2	-	13	1687	c.1150G>A	c.(1150-1152)GAC>AAC	p.D384N	DGKG_uc003fqb.2_Missense_Mutation_p.D345N|DGKG_uc003fqc.2_Missense_Mutation_p.D384N|DGKG_uc011brx.1_Missense_Mutation_p.D345N	NM_001346	NP_001337	P49619	DGKG_HUMAN	diacylglycerol kinase gamma isoform 1	384	Phorbol-ester/DAG-type 2.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	TCCCCACCGTCACACAACGTT	0.522		NaN											0	0	0	0.01441	0	56	101									
CPN2	1370	broad.mit.edu	37	3	194062300	194062300	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:194062300C>T	uc003fts.2	-	2	1222	c.1132G>A	c.(1132-1134)GAG>AAG	p.E378K		NM_001080513	NP_001073982	P22792	CPN2_HUMAN	carboxypeptidase N, polypeptide 2	378	LRR 12.				protein stabilization	extracellular region	enzyme regulator activity			ovary(5)	5	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.65e-05)		AAGATGCCCTCCGGAAGTGTG	0.602		NaN											0	0	0	0.01441	0	52	76									
SORCS2	57537	broad.mit.edu	37	4	7398029	7398029	+	Silent	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr4:7398029G>C	uc003gkb.3	+	2	495	c.495G>C	c.(493-495)CTG>CTC	p.L165L	SORCS2_uc011bwi.1_5'UTR	NM_020777	NP_065828	Q96PQ0	SORC2_HUMAN	VPS10 domain receptor protein SORCS 2 precursor	165	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(1)|central_nervous_system(1)	2						TCTTGATCCTGACGAAGTACT	0.517		NaN											0	0	0	0.005443	0	18	35									
TEC	7006	broad.mit.edu	37	4	48151605	48151605	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr4:48151605C>G	uc003gxz.2	-	11	1066	c.975G>C	c.(973-975)GAG>GAC	p.E325D		NM_003215	NP_003206	P42680	TEC_HUMAN	tec protein tyrosine kinase	325	SH2.				intracellular protein kinase cascade	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(4)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)	9						ATTCAATAATCTCAGGAATGG	0.343		NaN											0	0	0	0.000602	0	3	88									
KDR	3791	broad.mit.edu	37	4	55948135	55948135	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr4:55948135G>A	uc003has.2	-	29	4138	c.3836C>T	c.(3835-3837)TCT>TTT	p.S1279F	KDR_uc003hat.1_Missense_Mutation_p.S1279F	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	1279	Cytoplasmic (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	AAAAGATGGAGATAATTTGGT	0.388		NaN	Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			0	0	0	0.001855	0	9	102									
NAAA	27163	broad.mit.edu	37	4	76862017	76862017	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr4:76862017G>A	uc003hjb.2	-	1	150	c.86C>T	c.(85-87)TCG>TTG	p.S29L	NAAA_uc003hja.2_Missense_Mutation_p.S29L|NAAA_uc003hjc.3_Missense_Mutation_p.S29L|NAAA_uc003hjd.3_RNA|NAAA_uc011cbq.1_5'Flank|NAAA_uc010iiz.1_Missense_Mutation_p.S29L	NM_014435	NP_055250	Q02083	NAAA_HUMAN	N-acylethanolamine acid amidase isoform 1	29					lipid metabolic process	lysosome	hydrolase activity			skin(1)	1						TGCTGGGGGCGAGGCGGCTGA	0.756		NaN											0	0	0	0.008291	0	10	6									
HERC6	55008	broad.mit.edu	37	4	89361189	89361189	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr4:89361189G>C	uc011cdi.1	+	21	2902	c.2719G>C	c.(2719-2721)GAC>CAC	p.D907H	HERC6_uc011cdj.1_Missense_Mutation_p.D871H|HERC6_uc011cdk.1_RNA|HERC6_uc011cdl.1_RNA	NM_017912	NP_060382	Q8IVU3	HERC6_HUMAN	hect domain and RLD 6 isoform 1	907	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytosol	ubiquitin-protein ligase activity			lung(3)|ovary(1)|kidney(1)	5		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000222)		TACTGATTATGACTGGAAACA	0.378		NaN											0	0	0	0.007291	0	22	31									
FAM190A	401145	broad.mit.edu	37	4	91230198	91230198	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr4:91230198C>G	uc003hsv.3	+	2	1103	c.763C>G	c.(763-765)CAG>GAG	p.Q255E	FAM190A_uc003hsu.3_Missense_Mutation_p.Q255E|FAM190A_uc010ikv.2_RNA|FAM190A_uc003hsw.2_Missense_Mutation_p.Q255E	NM_001145065	NP_001138537	Q9C0I3	F190A_HUMAN	KIAA1680 protein isoform 1	255										large_intestine(1)|ovary(1)	2						TACCACAGCTCAGACACCTTC	0.433		NaN											0	0	0	0.01441	0	49	61									
BDH2	56898	broad.mit.edu	37	4	104003301	104003301	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr4:104003301C>A	uc003hwz.2	-	9	726	c.621G>T	c.(619-621)AAG>AAT	p.K207N	BDH2_uc003hxa.2_RNA	NM_020139	NP_064524	Q9BUT1	BDH2_HUMAN	3-hydroxybutyrate dehydrogenase, type 2	207					fatty acid beta-oxidation|heme metabolic process|iron ion homeostasis|siderophore biosynthetic process	cytoplasm	3-hydroxybutyrate dehydrogenase activity|NAD binding|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.02e-08)		ATCTTCCCGTCTTTTGTCTCT	0.458		NaN											1	0	2.17888e-05	0.006214	2.2289e-05	8	85									
TET2	54790	broad.mit.edu	37	4	106157401	106157401	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr4:106157401G>C	uc003hxk.2	+	3	2688	c.2302G>C	c.(2302-2304)GAT>CAT	p.D768H	TET2_uc011cez.1_Missense_Mutation_p.D789H|TET2_uc003hxj.2_RNA|TET2_uc010ilp.1_Missense_Mutation_p.D768H|TET2_uc003hxi.1_Missense_Mutation_p.D768H	NM_001127208	NP_001120680	Q6N021	TET2_HUMAN	tet oncogene family member 2 isoform a	768	Gln-rich.				cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			haematopoietic_and_lymphoid_tissue(732)|pancreas(1)	733		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		AAGCAACAATGATCAGCAAAG	0.383		NaN	Mis N|F		MDS								0	0	0	0.01441	0	42	54									
TET2	54790	broad.mit.edu	37	4	106158369	106158369	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr4:106158369G>C	uc003hxk.2	+	3	3656	c.3270G>C	c.(3268-3270)AAG>AAC	p.K1090N	TET2_uc011cez.1_Missense_Mutation_p.K1111N|TET2_uc003hxj.2_RNA|TET2_uc010ilp.1_Missense_Mutation_p.K1090N|TET2_uc003hxi.1_Missense_Mutation_p.K1090N	NM_001127208	NP_001120680	Q6N021	TET2_HUMAN	tet oncogene family member 2 isoform a	1090					cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.K1090fs*16(1)		haematopoietic_and_lymphoid_tissue(732)|pancreas(1)	733		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		CTTCAGAAAAGACACCAACCA	0.393		NaN	Mis N|F		MDS								0	0	0	0.003271	0	30	26									
TET2	54790	broad.mit.edu	37	4	106158415	106158415	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr4:106158415G>C	uc003hxk.2	+	3	3702	c.3316G>C	c.(3316-3318)GAG>CAG	p.E1106Q	TET2_uc011cez.1_Missense_Mutation_p.E1127Q|TET2_uc003hxj.2_RNA|TET2_uc010ilp.1_Missense_Mutation_p.E1106Q|TET2_uc003hxi.1_Missense_Mutation_p.E1106Q	NM_001127208	NP_001120680	Q6N021	TET2_HUMAN	tet oncogene family member 2 isoform a	1106					cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			haematopoietic_and_lymphoid_tissue(732)|pancreas(1)	733		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		TAATTTTATAGAGTCACCTTC	0.373		NaN	Mis N|F		MDS								0	0	0	0.00623	0	35	45									
INPP4B	8821	broad.mit.edu	37	4	143045828	143045828	+	Silent	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr4:143045828C>G	uc003iix.3	-	20	2401	c.1806G>C	c.(1804-1806)CTG>CTC	p.L602L	INPP4B_uc003iiw.3_Silent_p.L602L|INPP4B_uc011chm.1_RNA|INPP4B_uc011chn.1_Silent_p.L417L|INPP4B_uc011cho.1_RNA|INPP4B_uc011chp.1_Silent_p.L473L	NM_003866	NP_003857	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II,	602					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			ovary(1)|lung(1)	2	all_hematologic(180;0.158)					GCACAAATGTCAGGGACTGCT	0.537		NaN											0	0	0	0.013726	0	32	48									
MAP9	79884	broad.mit.edu	37	4	156289749	156289749	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr4:156289749G>C	uc003ios.2	-	5	961	c.697C>G	c.(697-699)CTT>GTT	p.L233V	MAP9_uc011cin.1_Missense_Mutation_p.L232V|MAP9_uc010iqa.1_RNA|MAP9_uc003iot.1_Missense_Mutation_p.L232V|MAP9_uc010iqb.1_Missense_Mutation_p.L160V	NM_001039580	NP_001034669	Q49MG5	MAP9_HUMAN	aster-associated protein	233					cell division|mitosis	cytoplasm|microtubule|spindle				ovary(1)|central_nervous_system(1)	2	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.143)		TCAGGATCAAGGTTTTCAGAG	0.378		NaN											0	0	0	0.003954	0	22	35									
ANXA10	11199	broad.mit.edu	37	4	169108570	169108570	+	Silent	SNP	T	T	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr4:169108570T>C	uc003irm.2	+	12	1105	c.960T>C	c.(958-960)GAT>GAC	p.D320D	ANXA10_uc003irn.2_Silent_p.D192D	NM_007193	NP_009124	Q9UJ72	ANX10_HUMAN	annexin A10	320							calcium ion binding|calcium-dependent phospholipid binding				0		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0325)		GTGCTGGTGATGCTGAGGACT	0.338		NaN											0	0	0	0.00874	0	32	42									
NEIL3	55247	broad.mit.edu	37	4	178274823	178274823	+	Silent	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr4:178274823G>A	uc003iut.2	+	8	1518	c.1401G>A	c.(1399-1401)CCG>CCA	p.P467P	NEIL3_uc010irs.2_3'UTR	NM_018248	NP_060718	Q8TAT5	NEIL3_HUMAN	nei endonuclease VIII-like 3	467					base-excision repair|nucleotide-excision repair	nucleus	bubble DNA binding|damaged DNA binding|DNA N-glycosylase activity|DNA-(apurinic or apyrimidinic site) lyase activity|double-stranded DNA binding|single-stranded DNA binding|zinc ion binding			lung(2)|ovary(1)|central_nervous_system(1)	4		Breast(14;6.27e-05)|Melanoma(52;0.00102)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.164)		all cancers(43;1.96e-23)|Epithelial(43;2.52e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.89e-11)|GBM - Glioblastoma multiforme(59;9.49e-05)|Colorectal(24;0.00013)|COAD - Colon adenocarcinoma(29;0.000696)|STAD - Stomach adenocarcinoma(60;0.00308)|LUSC - Lung squamous cell carcinoma(193;0.0398)|READ - Rectum adenocarcinoma(43;0.191)		ATAAAAAACCGAAAACAGCCC	0.353		NaN						BER_DNA_glycosylases					0	0	0	0.009718	0	35	51									
ODZ3	55714	broad.mit.edu	37	4	183713719	183713719	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr4:183713719G>A	uc003ivd.1	+	25	5931	c.5894G>A	c.(5893-5895)AGA>AAA	p.R1965K		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	1965	Extracellular (Potential).|YD 10.				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		GATAGCACAAGAGTCAGTTTT	0.418		NaN											0	0	0	0.01441	0	57	47									
PLEKHG4B	153478	broad.mit.edu	37	5	169623	169623	+	Silent	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr5:169623C>T	uc003jak.2	+	12	2627	c.2577C>T	c.(2575-2577)CAC>CAT	p.H859H		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	859	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		AGAAGCTCCACGACTTCCACC	0.567		NaN											0	0	0	0.01441	0	62	163									
CDH9	1007	broad.mit.edu	37	5	26988259	26988259	+	Missense_Mutation	SNP	A	A	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr5:26988259A>G	uc003jgs.1	-	2	351	c.182T>C	c.(181-183)TTC>TCC	p.F61S	CDH9_uc010iug.2_Missense_Mutation_p.F61S	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	61	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						TTCCAATAAGAAGAACTGATT	0.383		NaN											0	0	0	0.007413	0	14	34									
RNASEN	29102	broad.mit.edu	37	5	31526792	31526792	+	Missense_Mutation	SNP	G	G	A	rs149389256	by1000genomes	TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr5:31526792G>A	uc003jhg.2	-	4	607	c.248C>T	c.(247-249)CCA>CTA	p.P83L	RNASEN_uc003jhh.2_Missense_Mutation_p.P83L|RNASEN_uc003jhi.2_Missense_Mutation_p.P83L|RNASEN_uc010iui.1_Missense_Mutation_p.P74L	NM_013235	NP_037367	Q9NRR4	RNC_HUMAN	ribonuclease III, nuclear isoform 1	83	Pro-rich.				gene silencing by RNA|ribosome biogenesis|RNA processing	nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity				0						AGGCATGGGTGGGGGGAAGGG	0.577		NaN											0	0	0	0.004672	0	3	50									
PAIP1	10605	broad.mit.edu	37	5	43527531	43527531	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr5:43527531C>G	uc003job.2	-	11	1634	c.1387G>C	c.(1387-1389)GAA>CAA	p.E463Q	PAIP1_uc003joa.2_Missense_Mutation_p.E384Q|PAIP1_uc010ivp.2_Nonstop_Mutation_p.*352Y|PAIP1_uc010ivo.2_RNA|PAIP1_uc003joc.2_Missense_Mutation_p.E351Q	NM_006451	NP_006442	Q9H074	PAIP1_HUMAN	poly(A) binding protein interacting protein 1	463	PABPC1-interacting motif-1 (PAM1).				mRNA stabilization|nuclear-transcribed mRNA poly(A) tail shortening|translational initiation	cytosol	protein binding|RNA binding|translation activator activity			ovary(1)	1	Lung NSC(6;2.07e-05)					TAAGCTTCTTCTATCTCTGGG	0.333		NaN											0	0	0	0.006214	0	7	98									
ISL1	3670	broad.mit.edu	37	5	50685565	50685565	+	Silent	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr5:50685565G>C	uc003jor.2	+	4	1112	c.564G>C	c.(562-564)CTG>CTC	p.L188L		NM_002202	NP_002193	P61371	ISL1_HUMAN	islet-1	188	Homeobox.				generation of precursor metabolites and energy|multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3		Lung NSC(810;0.000845)|Breast(144;0.0411)				GGACTGTGCTGAACGAGAAGC	0.667		NaN											0	0	0	0.004482	0	9	43									
BDP1	55814	broad.mit.edu	37	5	70818248	70818248	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr5:70818248G>C	uc003kbp.1	+	23	5387	c.5124G>C	c.(5122-5124)CAG>CAC	p.Q1708H	BDP1_uc003kbo.2_Missense_Mutation_p.Q1708H|BDP1_uc003kbq.1_Intron	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	1708					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		CAACAGATCAGAGCAAGGAAG	0.388		NaN											0	0	0	0.00499	0	15	98									
BDP1	55814	broad.mit.edu	37	5	70820129	70820129	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr5:70820129G>C	uc003kbp.1	+	25	6014	c.5751G>C	c.(5749-5751)CAG>CAC	p.Q1917H	BDP1_uc003kbo.2_Missense_Mutation_p.Q1917H|BDP1_uc003kbq.1_RNA	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	1917					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		TTTCTGCTCAGATTGAGGAAA	0.383		NaN											0	0	0	0.008291	0	8	51									
MAN2A1	4124	broad.mit.edu	37	5	109026163	109026163	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr5:109026163C>G	uc003kou.1	+	1	1008	c.45C>G	c.(43-45)TTC>TTG	p.F15L	MAN2A1_uc003kot.1_RNA	NM_002372	NP_002363	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	15	Helical; Signal-anchor for type II membrane protein; (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		GTGCGATCTTCTGTGTGGTGA	0.582		NaN											0	0	0	0.006122	0	15	5									
CAMK4	814	broad.mit.edu	37	5	110710590	110710590	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr5:110710590C>T	uc011cvj.1	+	4	382	c.283C>T	c.(283-285)CGC>TGC	p.R95C	CAMK4_uc003kpf.2_Missense_Mutation_p.R95C|CAMK4_uc010jbv.2_Intron	NM_001744	NP_001735	Q16566	KCC4_HUMAN	calcium/calmodulin-dependent protein kinase IV	95	Protein kinase.				activation of phospholipase C activity|nerve growth factor receptor signaling pathway|synaptic transmission	cytosol|nucleoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(3)|lung(2)	5		all_cancers(142;1.49e-05)|all_epithelial(76;1.82e-07)|Prostate(80;0.00964)|all_lung(232;0.0181)|Lung NSC(167;0.0298)|Ovarian(225;0.0446)|Colorectal(57;0.0478)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;3.79e-08)|Epithelial(69;5.29e-08)|all cancers(49;1.1e-05)|COAD - Colon adenocarcinoma(37;0.109)		AGTTCTTCTTCGCCTCTCACA	0.393		NaN											0	0	0	0.006214	0	9	33									
ACSL6	23305	broad.mit.edu	37	5	131307298	131307298	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr5:131307298G>A	uc010jdo.1	-	14	1387	c.1304C>T	c.(1303-1305)GCA>GTA	p.A435V	ACSL6_uc003kvv.1_RNA|ACSL6_uc003kvx.1_Missense_Mutation_p.A460V|ACSL6_uc003kvy.1_Missense_Mutation_p.A460V|ACSL6_uc003kwb.2_Missense_Mutation_p.A425V|ACSL6_uc003kvz.1_Missense_Mutation_p.A360V|ACSL6_uc003kwa.1_Missense_Mutation_p.A446V|ACSL6_uc003kvw.1_Missense_Mutation_p.A81V|ACSL6_uc010jdn.1_Missense_Mutation_p.A450V	NM_015256	NP_056071	Q9UKU0	ACSL6_HUMAN	acyl-CoA synthetase long-chain family member 6	435	Cytoplasmic (Potential).				fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane|plasma membrane	ATP binding|long-chain fatty acid-CoA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(142;0.107)|Breast(839;0.198)|Lung NSC(810;0.216)|all_lung(232;0.248)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TGCTGGGGCTGCTCCAGTAAC	0.522		NaN											0	0	0	0.00278	0	19	3									
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	5	139917031	139917031	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr5:139917031G>A	uc003lfs.1	+	31	7209	c.7085G>A	c.(7084-7086)CGA>CAA	p.R2362Q	ANKHD1_uc003lfr.2_Missense_Mutation_p.R2362Q|ANKHD1-EIF4EBP3_uc011czh.1_Missense_Mutation_p.R1118Q|ANKHD1_uc003lfw.2_Missense_Mutation_p.R1017Q|ANKHD1_uc010jfl.2_Missense_Mutation_p.R738Q|ANKHD1-EIF4EBP3_uc003lfx.1_Missense_Mutation_p.R516Q	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	2362						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGTCAAGATCGAAAGATACCT	0.547		NaN											0	0	0	0.01441	0	44	27									
PCDHB7	56129	broad.mit.edu	37	5	140553317	140553317	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr5:140553317C>T	uc003lit.2	+	1	1075	c.901C>T	c.(901-903)CTT>TTT	p.L301F		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	301	Extracellular (Potential).|Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.L301P(1)		ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATCTGGCAGTCTTCATCTTAA	0.408		NaN											0	0	0	0.01441	0	73	12									
PCDHGB3	56102	broad.mit.edu	37	5	140750463	140750463	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr5:140750463C>T	uc003ljw.1	+	1	502	c.502C>T	c.(502-504)CAG>TAG	p.Q168*	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc011dat.1_Nonsense_Mutation_p.Q168*	NM_018924	NP_061747	Q9Y5G1	PCDGF_HUMAN	protocadherin gamma subfamily B, 3 isoform 1	168	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAATTCGCTGCAGCAGTACTA	0.512		NaN											0	0	0	0.001855	0	9	214									
FAT2	2196	broad.mit.edu	37	5	150925437	150925437	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr5:150925437C>A	uc003lue.3	-	9	5264	c.5251G>T	c.(5251-5253)GAA>TAA	p.E1751*	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1751	Cadherin 15.|Extracellular (Potential).				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTGTCATTTTCATCAATTATG	0.408		NaN											1	0	5.35267e-07	0.007413	5.53201e-07	18	147									
PANK3	79646	broad.mit.edu	37	5	167991021	167991021	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr5:167991021C>T	uc003lzz.1	-	4	985	c.685G>A	c.(685-687)GAA>AAA	p.E229K		NM_024594	NP_078870	Q9H999	PANK3_HUMAN	pantothenate kinase 3	229					coenzyme A biosynthetic process	cytoplasm|nucleus	ATP binding|pantothenate kinase activity			ovary(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0441)|all_lung(126;0.0909)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0989)|OV - Ovarian serous cystadenocarcinoma(192;0.147)|Epithelial(171;0.188)		TCAAAACTTTCACAGCCAGTC	0.383		NaN											0	0	0	0.013726	0	25	173									
ZNF354A	6940	broad.mit.edu	37	5	178152427	178152427	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr5:178152427C>G	uc003mjj.2	-	4	404	c.206G>C	c.(205-207)GGA>GCA	p.G69A		NM_005649	NP_005640	O60765	Z354A_HUMAN	zinc finger protein 354A	69	KRAB.				regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(1)	3	all_cancers(89;0.000536)|Renal(175;0.000159)|all_epithelial(37;0.000221)|Lung NSC(126;0.00308)|all_lung(126;0.00536)	all_cancers(40;0.0452)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.185)		GGGATCTTCTCCTTGCTGCAA	0.493		NaN											0	0	0	0.008361	0	21	133									
RUFY1	80230	broad.mit.edu	37	5	178977723	178977723	+	Silent	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr5:178977723G>A	uc003mka.1	+	1	153	c.153G>A	c.(151-153)CGG>CGA	p.R51R		NM_025158	NP_079434	Q96T51	RUFY1_HUMAN	RUN and FYVE domain-containing 1 isoform a	51					endocytosis|protein transport	early endosome membrane	lipid binding|zinc ion binding			ovary(4)|breast(1)	5	all_cancers(89;0.00018)|all_epithelial(37;8.37e-05)|Renal(175;0.000159)|Lung NSC(126;0.00108)|all_lung(126;0.00195)	all_cancers(40;0.0322)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCGACCTGCGGAGCGCAACGA	0.652		NaN								HNSCC(44;0.11)			0	0	0	0.008291	0	7	1									
DTNBP1	84062	broad.mit.edu	37	6	15523430	15523430	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr6:15523430G>C	uc003nbm.2	-	10	1003	c.832C>G	c.(832-834)CAG>GAG	p.Q278E	DTNBP1_uc003nbl.2_Missense_Mutation_p.Q197E|DTNBP1_uc003nbn.2_RNA|DTNBP1_uc003nbo.2_RNA	NM_032122	NP_115498	Q96EV8	DTBP1_HUMAN	dystrobrevin binding protein 1 isoform a	278	Dysbindin.				actin cytoskeleton reorganization|cellular membrane organization|neuron projection morphogenesis|post-Golgi vesicle-mediated transport|regulation of dopamine receptor signaling pathway	axon part|BLOC-1 complex|cell junction|dendritic spine|endoplasmic reticulum membrane|endosome membrane|growth cone|melanosome membrane|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|synaptic vesicle membrane|synaptosome	identical protein binding				0	Breast(50;0.0289)|Ovarian(93;0.103)	all_hematologic(90;0.0895)	Epithelial(50;0.211)			ATCTCATTCTGACAGGTACTG	0.488		NaN							Hermansky-Pudlak_syndrome				0	0	0	0.001168	0	4	185									
HIST1H3H	8357	broad.mit.edu	37	6	27778040	27778040	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr6:27778040C>G	uc003njm.2	+	1	199	c.189C>G	c.(187-189)ATC>ATG	p.I63M	HIST1H2BL_uc003njl.2_5'Flank	NM_003536	NP_003527	P68431	H31_HUMAN	histone cluster 1, H3h	63					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						AGCTGCTGATCAGAAAGCTGC	0.617		NaN											0	0	0	0.001168	0	4	71									
BAT2	7916	broad.mit.edu	37	6	31602332	31602332	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr6:31602332G>C	uc003nvb.3	+	20	5182	c.4933G>C	c.(4933-4935)GAA>CAA	p.E1645Q	BAT2_uc011dnv.1_Intron|BAT2_uc003nvc.3_Missense_Mutation_p.E1645Q	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	1645	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding				0						GGCTGGCACAGAAGTGAGTGA	0.582		NaN											0	0	0	0.00278	0	20	3									
EHMT2	10919	broad.mit.edu	37	6	31855876	31855876	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr6:31855876G>C	uc003nxz.1	-	13	1697	c.1687C>G	c.(1687-1689)CCT>GCT	p.P563A	EHMT2_uc003nxx.1_5'Flank|EHMT2_uc003nxy.1_Missense_Mutation_p.P354A|EHMT2_uc011don.1_Missense_Mutation_p.P586A|EHMT2_uc003nya.1_Missense_Mutation_p.P529A	NM_006709	NP_006700	Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	563					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			ovary(1)	1						GGGGGTGCAGGAGCTGCAGTG	0.652		NaN											0	0	0	0.004672	0	3	22									
PBX2	5089	broad.mit.edu	37	6	32156277	32156277	+	Silent	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr6:32156277G>A	uc003oav.1	-	3	571	c.300C>T	c.(298-300)CTC>CTT	p.L100L	PBX2_uc003oaw.2_Silent_p.L100L	NM_002586	NP_002577	P40425	PBX2_HUMAN	pre-B-cell leukemia homeobox 2	100							transcription factor binding			ovary(1)	1						TCCGAATGCTGAGGCCTAGCA	0.617		NaN											0	0	0	0.009535	0	25	5									
REV3L	5980	broad.mit.edu	37	6	111697267	111697267	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr6:111697267G>T	uc003puy.3	-	13	2614	c.2291C>A	c.(2290-2292)GCT>GAT	p.A764D	REV3L_uc003pux.3_Missense_Mutation_p.A686D|REV3L_uc003puz.3_Missense_Mutation_p.A686D	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	764					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		ACTTTCATCAGCAGTGCTATT	0.368		NaN						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					1	0	1.14069e-49	0.01441	1.23961e-49	96	17									
REV3L	5980	broad.mit.edu	37	6	111697396	111697396	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr6:111697396G>C	uc003puy.3	-	13	2485	c.2162C>G	c.(2161-2163)TCT>TGT	p.S721C	REV3L_uc003pux.3_Missense_Mutation_p.S643C|REV3L_uc003puz.3_Missense_Mutation_p.S643C	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	721					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		ATTTCCTTCAGAGGATACTTT	0.353		NaN						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.01441	0	50	7									
REV3L	5980	broad.mit.edu	37	6	111697611	111697611	+	Silent	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr6:111697611G>A	uc003puy.3	-	13	2270	c.1947C>T	c.(1945-1947)ATC>ATT	p.I649I	REV3L_uc003pux.3_Silent_p.I571I|REV3L_uc003puz.3_Silent_p.I571I	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	649					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		ATACTGGGAGGATCTCTTTCT	0.313		NaN						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.00333	0	23	2									
LAMA2	3908	broad.mit.edu	37	6	129777521	129777521	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr6:129777521G>A	uc003qbn.2	+	47	6854	c.6749G>A	c.(6748-6750)GGA>GAA	p.G2250E	LAMA2_uc003qbo.2_Missense_Mutation_p.G2250E	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	2250	Laminin G-like 1.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GCCCTGGATGGACCCAAAGCC	0.478		NaN											0	0	0	0.01441	0	104	26									
CARD11	84433	broad.mit.edu	37	7	2978453	2978453	+	Missense_Mutation	SNP	T	T	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr7:2978453T>A	uc003smv.2	-	7	1281	c.877A>T	c.(877-879)AGC>TGC	p.S293C		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	293	Potential.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		TCTGGCAGGCTGCGCTTCCCG	0.632		NaN	Mis		DLBCL								0	0	0	0.000602	0	4	84									
ACTB	60	broad.mit.edu	37	7	5568878	5568878	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr7:5568878C>G	uc003sos.3	-	2	313	c.277G>C	c.(277-279)GAG>CAG	p.E93Q	ACTB_uc003sor.3_5'UTR|ACTB_uc003sot.3_Missense_Mutation_p.E93Q|ACTB_uc003soq.3_5'UTR|ACTB_uc010ksy.2_Intron	NM_001101	NP_001092	P60709	ACTB_HUMAN	beta actin	93					'de novo' posttranslational protein folding|adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol|MLL5-L complex|NuA4 histone acetyltransferase complex|ribonucleoprotein complex	ATP binding|kinesin binding|nitric-oxide synthase binding|structural constituent of cytoskeleton				0		Ovarian(82;0.0606)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)|OV - Ovarian serous cystadenocarcinoma(56;4.24e-37)		ACACGCAGCTCATTGTAGAAG	0.617		NaN											0	0	0	0.001168	0	5	94									
DNAH11	8701	broad.mit.edu	37	7	21934388	21934388	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr7:21934388C>T	uc003svc.2	+	79	12950	c.12919C>T	c.(12919-12921)CGT>TGT	p.R4307C		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	4307					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TCGGGAAATACGTATATCACT	0.368		NaN							Kartagener_syndrome				0	0	0	0.008291	0	11	10									
C7orf30	115416	broad.mit.edu	37	7	23340550	23340550	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr7:23340550G>C	uc003swd.1	+	2	381	c.349G>C	c.(349-351)GAA>CAA	p.E117Q		NM_138446	NP_612455	Q96EH3	CG030_HUMAN	hypothetical protein LOC115416	117						mitochondrion					0			GBM - Glioblastoma multiforme(13;0.154)			GGTTCCTCCAGAAATGAGATA	0.408		NaN											0	0	0	0.01441	0	112	133									
PDE1C	5137	broad.mit.edu	37	7	31890295	31890295	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr7:31890295C>T	uc003tcm.1	-	8	1280	c.811G>A	c.(811-813)GAG>AAG	p.E271K	PDE1C_uc003tcn.1_Missense_Mutation_p.E271K|PDE1C_uc003tco.1_Missense_Mutation_p.E331K|PDE1C_uc003tcr.2_Missense_Mutation_p.E271K|PDE1C_uc003tcs.2_Missense_Mutation_p.E271K	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	271	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			CCGGTATGCTCGTAGTCATGG	0.443		NaN											0	0	0	0.003163	0	11	156									
EPDR1	54749	broad.mit.edu	37	7	37960519	37960519	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr7:37960519C>T	uc003tfp.2	+	1	357	c.338C>T	c.(337-339)TCG>TTG	p.S113L	EPDR1_uc003tfq.2_Missense_Mutation_p.S113L|EPDR1_uc010kxh.2_5'Flank	NM_017549	NP_060019	Q9UM22	EPDR1_HUMAN	ependymin related protein 1 precursor	Error:Variant_position_missing_in_Q9UM22_after_alignment					cell-matrix adhesion	extracellular region	calcium ion binding			upper_aerodigestive_tract(1)	1						GGCTTGCCCTCGGGCCGGGGA	0.736		NaN											0	0	0	0.013537	0	12	11									
DDC	1644	broad.mit.edu	37	7	50531017	50531017	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr7:50531017G>A	uc003tpf.3	-	14	1441	c.1355C>T	c.(1354-1356)TCT>TTT	p.S452F	DDC_uc010kza.2_Missense_Mutation_p.S367F|DDC_uc003tpg.3_Missense_Mutation_p.S452F	NM_000790	NP_000781	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid	452					cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(2)	2	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	CACCGTGCGAGAACAGATGGC	0.537		NaN											0	0	0	0.003271	0	30	30									
COBL	23242	broad.mit.edu	37	7	51095966	51095966	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr7:51095966C>T	uc003tpr.3	-	10	3012	c.2827G>A	c.(2827-2829)GAT>AAT	p.D943N	COBL_uc003tps.2_Missense_Mutation_p.D1000N|COBL_uc011kcl.1_Missense_Mutation_p.D943N|COBL_uc003tpp.3_Missense_Mutation_p.D729N|COBL_uc003tpq.3_Missense_Mutation_p.D884N|COBL_uc003tpo.3_Missense_Mutation_p.D485N	NM_015198	NP_056013	O75128	COBL_HUMAN	cordon-bleu homolog	943										skin(3)|ovary(2)	5	Glioma(55;0.08)					ACTGCCAAATCTTCCCCGTGG	0.562		NaN											0	0	0	0.000602	0	4	93									
SEMA3D	223117	broad.mit.edu	37	7	84671602	84671602	+	Splice_Site	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr7:84671602C>G	uc003uic.2	-	8	902	c.862_splice	c.e8-1	p.N288_splice	SEMA3D_uc010led.2_Splice_Site_p.N288_splice|SEMA3D_uc003uib.2_5'Flank	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor						cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						CTACATCATTCTGACATGAAA	0.373		NaN											0	0	0	0.01441	0	86	97									
ADAM22	53616	broad.mit.edu	37	7	87760697	87760697	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr7:87760697G>C	uc003ujn.2	+	11	1018	c.939G>C	c.(937-939)ATG>ATC	p.M313I	ADAM22_uc003ujj.1_Missense_Mutation_p.M313I|ADAM22_uc003ujk.1_Missense_Mutation_p.M313I|ADAM22_uc003ujl.1_Missense_Mutation_p.M313I|ADAM22_uc003ujm.2_Missense_Mutation_p.M313I|ADAM22_uc003ujo.2_Missense_Mutation_p.M313I|ADAM22_uc003ujp.1_Missense_Mutation_p.M365I	NM_021723	NP_068369	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22 isoform 1	313	Peptidase M12B.|Extracellular (Potential).				cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			GTGAGTTTATGAAATACAGGA	0.363		NaN											0	0	0	0.000602	0	3	88									
ANKIB1	54467	broad.mit.edu	37	7	91972349	91972349	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr7:91972349G>C	uc003ulw.2	+	6	1175	c.799G>C	c.(799-801)GAG>CAG	p.E267Q		NM_019004	NP_061877	Q9P2G1	AKIB1_HUMAN	ankyrin repeat and IBR domain containing 1	267							protein binding|zinc ion binding			lung(1)	1	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			CTGGGACAGGGAGAAATTACT	0.383		NaN											0	0	0	0.008291	0	10	155									
MET	4233	broad.mit.edu	37	7	116398529	116398529	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr7:116398529C>G	uc003vij.2	+	9	2306	c.2119C>G	c.(2119-2121)CTT>GTT	p.L707V	MET_uc010lkh.2_Missense_Mutation_p.L707V|MET_uc011kng.1_Missense_Mutation_p.L707V|MET_uc011knh.1_Missense_Mutation_p.L707V|MET_uc011kni.1_Missense_Mutation_p.L707V|MET_uc011knj.1_Missense_Mutation_p.L277V	NM_000245	NP_000236	P08581	MET_HUMAN	met proto-oncogene isoform b precursor	707	Extracellular (Potential).|IPT/TIG 2.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			upper_aerodigestive_tract(63)|lung(41)|kidney(18)|NS(10)|ovary(5)|thyroid(4)|central_nervous_system(4)|stomach(3)|liver(3)|pleura(2)|large_intestine(2)|breast(2)|testis(1)|skin(1)	159	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			AAACAGTATTCTTGAATGTTA	0.328		NaN	Mis		papillary renal|head-neck squamous cell 	papillary renal			Hereditary_Papillary_Renal_Carcinoma_(type_1)				0	0	0	0.009096	0	4	111									
MET	4233	broad.mit.edu	37	7	116398545	116398545	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr7:116398545C>G	uc003vij.2	+	9	2322	c.2135C>G	c.(2134-2136)CCA>CGA	p.P712R	MET_uc010lkh.2_Missense_Mutation_p.P712R|MET_uc011kng.1_Missense_Mutation_p.P712R|MET_uc011knh.1_Missense_Mutation_p.P712R|MET_uc011kni.1_Missense_Mutation_p.P712R|MET_uc011knj.1_Missense_Mutation_p.P282R	NM_000245	NP_000236	P08581	MET_HUMAN	met proto-oncogene isoform b precursor	712	Extracellular (Potential).|IPT/TIG 2.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			upper_aerodigestive_tract(63)|lung(41)|kidney(18)|NS(10)|ovary(5)|thyroid(4)|central_nervous_system(4)|stomach(3)|liver(3)|pleura(2)|large_intestine(2)|breast(2)|testis(1)|skin(1)	159	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			TGTTATACCCCAGCCCAAACC	0.338		NaN	Mis		papillary renal|head-neck squamous cell 	papillary renal			Hereditary_Papillary_Renal_Carcinoma_(type_1)				0	0	0	0.001168	0	4	123									
C7orf58	79974	broad.mit.edu	37	7	120906763	120906763	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr7:120906763C>T	uc003vjq.3	+	20	2981	c.2534C>T	c.(2533-2535)TCA>TTA	p.S845L		NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	845						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					AATTTCAGATCACGTCCCCTA	0.403		NaN											0	0	0	0.001984	0	5	87									
AKR1B10	57016	broad.mit.edu	37	7	134216707	134216707	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr7:134216707G>C	uc003vrr.2	+	3	602	c.282G>C	c.(280-282)GAG>GAC	p.E94D		NM_020299	NP_064695	O60218	AK1BA_HUMAN	aldo-keto reductase family 1, member B10	94					cellular aldehyde metabolic process|digestion|steroid metabolic process	cytoplasm	aldo-keto reductase (NADP) activity|protein binding			skin(5)	5						AAGCCTTTGAGAAGACCCTCA	0.468		NaN											0	0	0	0.004482	0	8	136									
CUL1	8454	broad.mit.edu	37	7	148484180	148484180	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr7:148484180G>A	uc010lpg.2	+	13	1973	c.1447G>A	c.(1447-1449)GAT>AAT	p.D483N	CUL1_uc003wey.2_Missense_Mutation_p.D483N|CUL1_uc003wez.2_Missense_Mutation_p.D373N|CUL1_uc003wfa.2_Missense_Mutation_p.D144N	NM_003592	NP_003583	Q13616	CUL1_HUMAN	cullin 1	483					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			lung(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			TGCAAGTGACGATGCCGAAGC	0.413		NaN											0	0	0	0.01441	0	47	41									
KCNH2	3757	broad.mit.edu	37	7	150649632	150649632	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr7:150649632C>T	uc003wic.2	-	6	1451	c.1438G>A	c.(1438-1440)GAG>AAG	p.E480K	KCNH2_uc003wib.2_Missense_Mutation_p.E140K|KCNH2_uc011kux.1_Missense_Mutation_p.E384K|KCNH2_uc003wid.2_Missense_Mutation_p.E140K|KCNH2_uc003wie.2_Missense_Mutation_p.E480K	NM_000238	NP_000229	Q12809	KCNH2_HUMAN	voltage-gated potassium channel, subfamily H,	480	Cytoplasmic (Potential).				blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity	p.E480E(1)		skin(3)|ovary(1)	4	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	ACCACCTCCTCGTTGGCATTG	0.597		NaN											0	0	0	0.004482	0	7	121									
GALNTL5	168391	broad.mit.edu	37	7	151699831	151699831	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr7:151699831G>A	uc003wkp.2	+	6	914	c.691G>A	c.(691-693)GAG>AAG	p.E231K	GALNTL5_uc003wkq.2_5'UTR|GALNTL5_uc003wkr.2_RNA|GALNTL5_uc003wks.2_RNA|GALNTL5_uc010lqf.2_Missense_Mutation_p.E120K	NM_145292	NP_660335	Q7Z4T8	GLTL5_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	231	Catalytic subdomain A.|Lumenal (Potential).					Golgi membrane|integral to membrane	transferase activity, transferring glycosyl groups			ovary(2)	2	all_neural(206;0.187)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00427)	UCEC - Uterine corpus endometrioid carcinoma (81;0.18)|BRCA - Breast invasive adenocarcinoma(188;0.166)		CAGCCACTGTGAGGTGAACAG	0.502		NaN											0	0	0	0.00623	0	36	39									
MLL3	58508	broad.mit.edu	37	7	151949650	151949650	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr7:151949650G>T	uc003wla.2	-	10	1669	c.1450C>A	c.(1450-1452)CAT>AAT	p.H484N		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	484	DHHC-type.|PHD-type 3.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		ATATTACAATGAAGCATGTCT	0.368		NaN	N		medulloblastoma								1	0	6.02846e-25	0.003271	6.44643e-25	28	33									
DUSP26	78986	broad.mit.edu	37	8	33454844	33454844	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr8:33454844C>T	uc003xjp.2	-	2	523	c.190G>A	c.(190-192)GAG>AAG	p.E64K	DUSP26_uc003xjq.2_Missense_Mutation_p.E64K	NM_024025	NP_076930	Q9BV47	DUS26_HUMAN	dual specificity phosphatase 26	64	Tyrosine-protein phosphatase.					Golgi apparatus|nucleus	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0				KIRC - Kidney renal clear cell carcinoma(67;0.0918)|Kidney(114;0.111)		GGCCAGACCTCGTCGGCATGG	0.557		NaN											0	0	0	0.001855	0	12	2									
PRKDC	5591	broad.mit.edu	37	8	48761858	48761858	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr8:48761858C>A	uc003xqi.2	-	55	7194	c.7137G>T	c.(7135-7137)ATG>ATT	p.M2379I	PRKDC_uc003xqj.2_Missense_Mutation_p.M2379I|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	2379					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				ACACAGCATTCATGAACCTGG	0.542		NaN						NHEJ					1	0	1.15088e-07	0.004007	1.19251e-07	14	132									
NSMAF	8439	broad.mit.edu	37	8	59522183	59522183	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr8:59522183G>A	uc003xtt.2	-	10	881	c.667C>T	c.(667-669)CAG>TAG	p.Q223*	NSMAF_uc011lee.1_Nonsense_Mutation_p.Q254*|NSMAF_uc003xtu.2_Nonsense_Mutation_p.Q223*	NM_003580	NP_003571	Q92636	FAN_HUMAN	neutral sphingomyelinase (N-SMase) activation	223	GRAM.				ceramide metabolic process	cytoplasm|soluble fraction	protein binding|receptor signaling protein activity			ovary(1)	1		all_lung(136;0.174)|Lung NSC(129;0.2)				TTGAGGGGCTGAAAATACAGG	0.532		NaN											0	0	0	0.004289	0	31	37									
KCNB2	9312	broad.mit.edu	37	8	73849046	73849046	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr8:73849046C>G	uc003xzb.2	+	3	2044	c.1456C>G	c.(1456-1458)CAC>GAC	p.H486D		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	486	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			CGACGATAATCACCTGTCGCC	0.512		NaN											0	0	0	0.004007	0	16	163									
PI15	51050	broad.mit.edu	37	8	75761397	75761397	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr8:75761397G>T	uc003yal.2	+	6	865	c.686G>T	c.(685-687)TGT>TTT	p.C229F	uc003yak.1_Intron|PI15_uc003yam.2_Missense_Mutation_p.C229F	NM_015886	NP_056970	O43692	PI15_HUMAN	protease inhibitor 15 preproprotein	229						extracellular region	peptidase inhibitor activity			central_nervous_system(2)|ovary(1)	3	Breast(64;0.137)		BRCA - Breast invasive adenocarcinoma(89;0.104)|Epithelial(68;0.118)			GGGGTACCATGTTCATCTTGT	0.393		NaN											1	0	4.4782e-45	0.01441	4.8273e-45	78	100									
MMP16	4325	broad.mit.edu	37	8	89180039	89180039	+	Missense_Mutation	SNP	A	A	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr8:89180039A>T	uc003yeb.3	-	4	850	c.568T>A	c.(568-570)TCT>ACT	p.S190T	MMP16_uc003yec.2_Missense_Mutation_p.S190T	NM_005941	NP_005932	P51512	MMP16_HUMAN	matrix metalloproteinase 16 isoform 1	190	Extracellular (Potential).				collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)|urinary_tract(1)|skin(1)|kidney(1)	8						TGGAAACCAGATGCAAAAATA	0.438		NaN											0	0	0	0.006999	0	37	36									
UBR5	51366	broad.mit.edu	37	8	103358508	103358508	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr8:103358508C>T	uc003ykr.1	-	7	725	c.692G>A	c.(691-693)GGA>GAA	p.G231E	UBR5_uc003yks.1_Missense_Mutation_p.G231E	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	231					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			CCCATCATCTCCATCTTCATC	0.433		NaN											0	0	0	0.01441	0	84	197									
UBR5	51366	broad.mit.edu	37	8	103358578	103358578	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr8:103358578C>T	uc003ykr.1	-	7	655	c.622G>A	c.(622-624)GAA>AAA	p.E208K	UBR5_uc003yks.1_Missense_Mutation_p.E208K	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	208					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			CTCTGAAGTTCTCGAATAATG	0.353		NaN											0	0	0	0.01441	0	46	90									
UBR5	51366	broad.mit.edu	37	8	103373849	103373849	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr8:103373849C>T	uc003ykr.1	-	2	101	c.68G>A	c.(67-69)CGA>CAA	p.R23Q	UBR5_uc003yks.1_Missense_Mutation_p.R23Q	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	23					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			AGAAACTTCTCGTAACCTTTA	0.269		NaN											0	0	0	0.005443	0	24	40									
DPYS	1807	broad.mit.edu	37	8	105436556	105436556	+	Missense_Mutation	SNP	A	A	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr8:105436556A>C	uc003yly.3	-	7	1283	c.1154T>G	c.(1153-1155)ATT>AGT	p.I385S		NM_001385	NP_001376	Q14117	DPYS_HUMAN	dihydropyrimidinase	385					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			GAGATTAAAAATTTTGGCTGC	0.353		NaN											0	0	0	0.010818	0	30	42									
LRP12	29967	broad.mit.edu	37	8	105509596	105509596	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr8:105509596C>T	uc003yma.2	-	5	1279	c.1184G>A	c.(1183-1185)TGT>TAT	p.C395Y	LRP12_uc003ymb.2_Missense_Mutation_p.C376Y|LRP12_uc003ylz.2_5'Flank	NM_013437	NP_038465	Q9Y561	LRP12_HUMAN	low density lipoprotein-related protein 12	395	Extracellular (Potential).|LDL-receptor class A 3.				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			ATACCCATCACAACGCTGCTG	0.463		NaN											0	0	0	0.006214	0	8	118									
DOCK8	81704	broad.mit.edu	37	9	434934	434934	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:434934G>C	uc003zgf.2	+	39	5150	c.5038G>C	c.(5038-5040)GAG>CAG	p.E1680Q	DOCK8_uc010mgu.2_Missense_Mutation_p.E982Q|DOCK8_uc010mgv.2_Missense_Mutation_p.E1580Q|DOCK8_uc003zgk.2_Missense_Mutation_p.E1138Q	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1680	DHR-2.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		GAGCATGCTGGAGGACCACAG	0.488		NaN											0	0	0	0.007413	0	14	46									
DMRT1	1761	broad.mit.edu	37	9	841870	841870	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:841870C>G	uc003zgv.2	+	1	181	c.32C>G	c.(31-33)TCT>TGT	p.S11C	DMRT1_uc003zgu.1_Missense_Mutation_p.S11C	NM_021951	NP_068770	Q9Y5R6	DMRT1_HUMAN	doublesex and mab-3 related transcription factor	11					cell differentiation|male gonad development|sex determination	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		all_lung(10;2.66e-10)|Lung NSC(10;2.82e-10)|Breast(48;0.232)		Lung(218;0.037)		AGCAAGCCCTCTACACCGTCG	0.692		NaN											0	0	0	0.004482	0	7	15									
PDCD1LG2	80380	broad.mit.edu	37	9	5534978	5534978	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:5534978G>A	uc003zjg.3	+	3	562	c.289G>A	c.(289-291)GAA>AAA	p.E97K	C9orf46_uc003zjd.2_Intron|PDCD1LG2_uc011lmc.1_Missense_Mutation_p.E97K|PDCD1LG2_uc011lmd.1_Missense_Mutation_p.E97K|PDCD1LG2_uc010mhp.1_Missense_Mutation_p.E97K|PDCD1LG2_uc010mho.1_Missense_Mutation_p.E97K	NM_025239	NP_079515	Q9BQ51	PD1L2_HUMAN	programmed cell death 1 ligand 2 precursor	97	Ig-like V-type.|Extracellular (Potential).				immune response|T cell costimulation	endomembrane system|extracellular region|integral to membrane|plasma membrane	receptor activity				0	all_hematologic(13;0.158)	Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000767)|Lung(218;0.112)		AGTGAGGGACGAAGGACAGTA	0.507		NaN											0	0	0	0.00632	0	26	38									
PTPRD	5789	broad.mit.edu	37	9	8499822	8499822	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:8499822C>T	uc003zkk.2	-	24	2858	c.2147G>A	c.(2146-2148)CGC>CAC	p.R716H	PTPRD_uc003zkp.2_Intron|PTPRD_uc003zkq.2_Intron|PTPRD_uc003zkr.2_Intron|PTPRD_uc003zks.2_Intron|PTPRD_uc003zkl.2_Missense_Mutation_p.R716H|PTPRD_uc003zkm.2_Missense_Mutation_p.R703H|PTPRD_uc003zkn.2_Intron|PTPRD_uc003zko.2_Intron	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	716	Fibronectin type-III 5.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CTCGACTTTGCGAGGAGGACC	0.448		NaN								TSP Lung(15;0.13)			0	0	0	0.004878	0	30	51									
MLLT3	4300	broad.mit.edu	37	9	20414340	20414340	+	Silent	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:20414340G>A	uc003zoe.2	-	5	763	c.504C>T	c.(502-504)AGC>AGT	p.S168S	MLLT3_uc011lne.1_Silent_p.S136S|MLLT3_uc011lnf.1_Silent_p.S165S|MLLT3_uc003zof.2_5'UTR|MLLT3_uc011lng.1_Missense_Mutation_p.A130V	NM_004529	NP_004520	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	168	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.144		NaN	T	MLL	ALL								0	0	0	0.004672	0	3	20									
MLLT3	4300	broad.mit.edu	37	9	20414343	20414343	+	Silent	SNP	A	A	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:20414343A>G	uc003zoe.2	-	5	760	c.501T>C	c.(499-501)AGT>AGC	p.S167S	MLLT3_uc011lne.1_Silent_p.S135S|MLLT3_uc011lnf.1_Silent_p.S164S|MLLT3_uc003zof.2_5'UTR|MLLT3_uc011lng.1_Missense_Mutation_p.V129A	NM_004529	NP_004520	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	167	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctactgctgctgc	0.139		NaN	T	MLL	ALL								0	0	0	0.004672	0	3	18									
RUSC2	9853	broad.mit.edu	37	9	35555321	35555321	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:35555321G>A	uc003zww.2	+	3	2534	c.2279G>A	c.(2278-2280)AGA>AAA	p.R760K	RUSC2_uc010mkq.2_RNA|RUSC2_uc003zwx.3_Missense_Mutation_p.R760K	NM_014806	NP_055621	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	760						cytosol				ovary(1)	1			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			GCCACTGGCAGAGGTGCCAGG	0.667		NaN											0	0	0	0.01441	0	56	59									
RUSC2	9853	broad.mit.edu	37	9	35555344	35555344	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:35555344G>A	uc003zww.2	+	3	2557	c.2302G>A	c.(2302-2304)GAG>AAG	p.E768K	RUSC2_uc010mkq.2_RNA|RUSC2_uc003zwx.3_Missense_Mutation_p.E768K	NM_014806	NP_055621	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	768						cytosol				ovary(1)	1			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			AGCTGGGTCTGAGCCAGAGAC	0.657		NaN											0	0	0	0.01441	0	87	88									
RUSC2	9853	broad.mit.edu	37	9	35560379	35560379	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:35560379G>A	uc003zww.2	+	10	3997	c.3742G>A	c.(3742-3744)GAA>AAA	p.E1248K	RUSC2_uc010mkq.2_RNA|RUSC2_uc003zwx.3_Missense_Mutation_p.E1248K	NM_014806	NP_055621	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	1248	Poly-Glu.					cytosol				ovary(1)	1			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			agaggagacagaagaggtggc	0.517		NaN											0	0	0	0.013537	0	8	18									
RUSC2	9853	broad.mit.edu	37	9	35560391	35560391	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:35560391G>A	uc003zww.2	+	10	4009	c.3754G>A	c.(3754-3756)GAG>AAG	p.E1252K	RUSC2_uc010mkq.2_RNA|RUSC2_uc003zwx.3_Missense_Mutation_p.E1252K	NM_014806	NP_055621	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	1252						cytosol				ovary(1)	1			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			agaggtggcagaggcagCCGG	0.502		NaN											0	0	0	0.008871	0	15	23									
SLC28A3	64078	broad.mit.edu	37	9	86900922	86900922	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:86900922G>T	uc010mpz.2	-	13	1510	c.1385C>A	c.(1384-1386)TCT>TAT	p.S462Y	SLC28A3_uc011lsy.1_Missense_Mutation_p.S393Y|SLC28A3_uc004anu.1_Missense_Mutation_p.S462Y	NM_022127	NP_071410	Q9HAS3	S28A3_HUMAN	concentrative Na+-nucleoside cotransporter	462	Helical; (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|plasma membrane	nucleoside binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|skin(1)	4						ATTCATAAAAGACAGCAGGGC	0.498		NaN											1	0	5.35356e-11	0.00278	5.63458e-11	18	31									
DAPK1	1612	broad.mit.edu	37	9	90296407	90296407	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:90296407G>A	uc004apc.2	+	20	2228	c.2090G>A	c.(2089-2091)GGA>GAA	p.G697E	DAPK1_uc004apd.2_Missense_Mutation_p.G697E|DAPK1_uc011ltg.1_Missense_Mutation_p.G697E|DAPK1_uc011lth.1_Missense_Mutation_p.G434E|DAPK1_uc004apf.1_Missense_Mutation_p.G251E	NM_004938	NP_004929	P53355	DAPK1_HUMAN	death-associated protein kinase 1	697					apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			ovary(1)|breast(1)	2						GGCCACTCGGGATCCGGGAAA	0.552		NaN							Chronic_Lymphocytic_Leukemia_Familial_Clustering_of				0	0	0	0.01441	0	77	75									
IPPK	64768	broad.mit.edu	37	9	95418779	95418779	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:95418779C>T	uc004asl.1	-	3	461	c.184G>A	c.(184-186)GTC>ATC	p.V62I		NM_022755	NP_073592	Q9H8X2	IPPK_HUMAN	inositol 1,3,4,5,6-pentakisphosphate 2-kinase	62					inositol or phosphatidylinositol phosphorylation	cytoplasm|nucleus	ATP binding|inositol pentakisphosphate 2-kinase activity			ovary(2)	2						TCCTTCATGACATTTTTCCCA	0.433		NaN											0	0	0	0.01441	0	55	79									
SMC2	10592	broad.mit.edu	37	9	106882409	106882409	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:106882409G>A	uc004bbv.2	+	16	2386	c.2098G>A	c.(2098-2100)GAG>AAG	p.E700K	SMC2_uc004bbu.1_Missense_Mutation_p.E700K|SMC2_uc004bbw.2_Missense_Mutation_p.E700K|SMC2_uc011lvl.1_Missense_Mutation_p.E700K|SMC2_uc004bbx.2_Missense_Mutation_p.E700K	NM_001042551	NP_001036016	O95347	SMC2_HUMAN	structural maintenance of chromosomes 2	700	Potential.				cell division|mitotic chromosome condensation|symbiosis, encompassing mutualism through parasitism	condensin complex|cytoplasm|nuclear chromosome	ATP binding|protein heterodimerization activity			ovary(4)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|breast(1)	9						GGCTCTAGAAGAGGAATTAGC	0.353		NaN											0	0	0	0.01441	0	80	95									
OR13C2	392376	broad.mit.edu	37	9	107367631	107367631	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:107367631G>A	uc011lvq.1	-	1	278	c.278C>T	c.(277-279)TCC>TTC	p.S93F		NM_001004481	NP_001004481	Q8NGS9	O13C2_HUMAN	olfactory receptor, family 13, subfamily C,	93	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GCCAGAAAGGGAAATGGTCTT	0.517		NaN											0	0	0	0.01441	0	51	59									
SVEP1	79987	broad.mit.edu	37	9	113341490	113341490	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:113341490C>G	uc010mtz.2	-	1	671	c.334G>C	c.(334-336)GAC>CAC	p.D112H	SVEP1_uc010mua.1_Missense_Mutation_p.D112H|SVEP1_uc004beu.2_Missense_Mutation_p.D112H|uc004bew.1_5'Flank	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	112	VWFA.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						ACGGGGAAGTCGGACAGCAGC	0.642		NaN											0	0	0	0.004672	0	2	1									
TLR4	7099	broad.mit.edu	37	9	120476771	120476771	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:120476771C>G	uc004bjz.2	+	3	2656	c.2365C>G	c.(2365-2367)CTC>GTC	p.L789V	TLR4_uc004bka.2_Missense_Mutation_p.L749V|TLR4_uc004bkb.2_Missense_Mutation_p.L589V	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	789	Cytoplasmic (Potential).|TIR.				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						GTACCGCCTTCTCAGCAGGAA	0.552		NaN											0	0	0	0.01441	0	50	55									
PBX3	5090	broad.mit.edu	37	9	128677988	128677988	+	Nonsense_Mutation	SNP	G	G	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:128677988G>T	uc004bqb.2	+	3	414	c.298G>T	c.(298-300)GAG>TAG	p.E100*	PBX3_uc004bqc.2_Intron|PBX3_uc004bqd.2_Intron|PBX3_uc011lzw.1_Nonsense_Mutation_p.E25*|PBX3_uc011lzx.1_Nonsense_Mutation_p.E11*|PBX3_uc004bqe.2_5'UTR	NM_006195	NP_006186	P40426	PBX3_HUMAN	pre-B-cell leukemia homeobox 3 isoform 1	100					anterior compartment pattern formation|posterior compartment specification		sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)	1						AGGAGCCCAGGAGGAGGACCC	0.413		NaN											1	0	0.000673444	0.008291	0.000687153	11	12									
ZBTB34	403341	broad.mit.edu	37	9	129642198	129642198	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:129642198C>G	uc004bqm.3	+	2	605	c.508C>G	c.(508-510)CAG>GAG	p.Q170E		NM_001099270	NP_001092740	Q8NCN2	ZBT34_HUMAN	zinc finger and BTB domain containing 34	170					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ATATTGCTCTCAGGGACGGCA	0.592		NaN											0	0	0	0.01441	0	40	46									
ZBTB34	403341	broad.mit.edu	37	9	129642324	129642324	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:129642324G>C	uc004bqm.3	+	2	731	c.634G>C	c.(634-636)GAG>CAG	p.E212Q		NM_001099270	NP_001092740	Q8NCN2	ZBT34_HUMAN	zinc finger and BTB domain containing 34	212					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TTCTGAATATGAGATTCAGAT	0.577		NaN											0	0	0	0.001984	0	6	45									
FAM129B	64855	broad.mit.edu	37	9	130280190	130280190	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:130280190G>C	uc004brh.2	-	6	822	c.620C>G	c.(619-621)CCT>CGT	p.P207R	FAM129B_uc004bri.2_Missense_Mutation_p.P194R|FAM129B_uc004brj.3_Missense_Mutation_p.P207R	NM_022833	NP_073744	Q96TA1	NIBL1_HUMAN	hypothetical protein LOC64855 isoform 1	207							protein binding				0						TGTGAACGCAGGGCCCTCTAC	0.612		NaN											0	0	0	0.00278	0	21	17									
GOLGA2	2801	broad.mit.edu	37	9	131023520	131023520	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:131023520C>T	uc011maw.1	-	16	1283	c.1270G>A	c.(1270-1272)GAG>AAG	p.E424K	GOLGA2_uc010mxw.2_Intron|GOLGA2_uc004buh.2_5'Flank|GOLGA2_uc004bul.1_Missense_Mutation_p.E325K|uc004bun.2_5'Flank	NM_004486	NP_004477	Q08379	GOGA2_HUMAN	Golgi autoantigen, golgin subfamily a, 2	424	Potential.					Golgi cisterna membrane	protein binding			ovary(1)	1						CATTCCTTCTCCTCTCTCAAT	0.607		NaN											0	0	0	0.007413	0	16	160									
SPTAN1	6709	broad.mit.edu	37	9	131346753	131346753	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:131346753G>C	uc004bvl.3	+	17	2499	c.2386G>C	c.(2386-2388)GAG>CAG	p.E796Q	SPTAN1_uc011mbg.1_Missense_Mutation_p.E796Q|SPTAN1_uc011mbh.1_Missense_Mutation_p.E808Q|SPTAN1_uc004bvm.3_Missense_Mutation_p.E796Q|SPTAN1_uc004bvn.3_Missense_Mutation_p.E796Q	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	796	Spectrin 9.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						TGTTGAGGATGAGGAGACGTG	0.562		NaN											0	0	0	0.00245	0	13	26									
SPTAN1	6709	broad.mit.edu	37	9	131348070	131348070	+	Silent	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:131348070G>A	uc004bvl.3	+	19	2717	c.2604G>A	c.(2602-2604)CTG>CTA	p.L868L	SPTAN1_uc011mbg.1_Silent_p.L868L|SPTAN1_uc011mbh.1_Silent_p.L880L|SPTAN1_uc004bvm.3_Silent_p.L868L|SPTAN1_uc004bvn.3_Silent_p.L868L	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	868	Spectrin 9.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						TTCACGAGCTGAACCAAAAGT	0.527		NaN											0	0	0	0.009535	0	28	61									
SPTAN1	6709	broad.mit.edu	37	9	131348091	131348091	+	Silent	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:131348091G>A	uc004bvl.3	+	19	2738	c.2625G>A	c.(2623-2625)CTG>CTA	p.L875L	SPTAN1_uc011mbg.1_Silent_p.L875L|SPTAN1_uc011mbh.1_Silent_p.L887L|SPTAN1_uc004bvm.3_Silent_p.L875L|SPTAN1_uc004bvn.3_Silent_p.L875L	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	875	Spectrin 9.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						GGGAGGCACTGAAAGCCAAAG	0.537		NaN											0	0	0	0.004289	0	31	51									
BRD3	8019	broad.mit.edu	37	9	136917464	136917464	+	Silent	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:136917464G>A	uc004cew.2	-	3	503	c.315C>T	c.(313-315)TTC>TTT	p.F105F	BRD3_uc004cex.2_Silent_p.F105F	NM_007371	NP_031397	Q15059	BRD3_HUMAN	bromodomain containing protein 3	105	Bromo 1.					nucleus	protein binding		BRD3/C15orf55(3)	stomach(4)|midline_organs(3)|kidney(1)	8				OV - Ovarian serous cystadenocarcinoma(145;1.43e-08)|Epithelial(140;8.41e-08)|all cancers(34;5.21e-07)		ACATGGTGTTGAAGTCCTGCA	0.398		NaN	T	NUT|C15orf55	lethal midline carcinoma of young people								0	0	0	0.000602	0	5	52									
UAP1L1	91373	broad.mit.edu	37	9	139973451	139973451	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:139973451G>A	uc010ncb.2	+	4	726	c.694G>A	c.(694-696)GCG>ACG	p.A232T	UAP1L1_uc004cla.3_Missense_Mutation_p.A109T	NM_207309	NP_997192	Q3KQV9	UAP1L_HUMAN	UDP-N-acteylglucosamine pyrophosphorylase 1-like	232							nucleotidyltransferase activity			ovary(1)	1	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;2.96e-05)|Epithelial(140;0.000486)		CCTCTACTGCGCGCTGGAGGA	0.652		NaN											0	0	0	0.01441	0	37	36									
TUBB2C	10383	broad.mit.edu	37	9	140137804	140137804	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:140137804C>G	uc004cmh.1	+	4	1236	c.1134C>G	c.(1132-1134)TTC>TTG	p.F378L	TUBB2C_uc004cmg.1_Missense_Mutation_p.F232L	NM_006088	NP_006079	P68371	TBB2C_HUMAN	tubulin, beta, 2	378					'de novo' posttranslational protein folding|cellular component movement|G2/M transition of mitotic cell cycle|microtubule-based movement|natural killer cell mediated cytotoxicity|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|MHC class I protein binding|structural molecule activity|unfolded protein binding			ovary(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		AGGAGCTGTTCAAGCGCATCT	0.597		NaN											0	0	0	0.01441	0	82	171									
SHROOM2	357	broad.mit.edu	37	X	9863321	9863321	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chrX:9863321C>T	uc004csu.1	+	4	1463	c.1373C>T	c.(1372-1374)CCT>CTT	p.P458L		NM_001649	NP_001640	Q13796	SHRM2_HUMAN	apical protein of Xenopus-like	458					apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8		Hepatocellular(5;0.000888)				GACAGCCCTCCTCAGGTGAGG	0.677		NaN											0	0	0	0.001984	0	6	26									
MID1	4281	broad.mit.edu	37	X	10427830	10427830	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chrX:10427830C>G	uc004cte.3	-	8	1494	c.1303G>C	c.(1303-1305)GAT>CAT	p.D435H	MID1_uc004ctd.3_Missense_Mutation_p.D146H|MID1_uc004ctg.3_Missense_Mutation_p.D435H|MID1_uc004cth.3_Missense_Mutation_p.D397H|MID1_uc004ctk.3_Missense_Mutation_p.D435H|MID1_uc004cti.3_Missense_Mutation_p.D435H|MID1_uc004ctj.3_Missense_Mutation_p.D435H|MID1_uc011mie.1_RNA|MID1_uc004csz.3_Missense_Mutation_p.D107H|MID1_uc004cta.3_Missense_Mutation_p.D191H|MID1_uc004ctb.3_Missense_Mutation_p.D95H|MID1_uc004ctc.3_Missense_Mutation_p.D202H	NM_033290	NP_150632	O15344	TRI18_HUMAN	midline 1	435	Fibronectin type-III.				microtubule cytoskeleton organization|pattern specification process|positive regulation of stress-activated MAPK cascade	cytoplasm|microtubule|microtubule associated complex|spindle	ligase activity|ubiquitin protein ligase binding|zinc ion binding			ovary(2)|pancreas(1)	3						ATCCAGCTATCAGCCGAATTA	0.463		NaN											0	0	0	0.013537	0	9	144									
FAM47C	442444	broad.mit.edu	37	X	37027200	37027200	+	Silent	SNP	A	A	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chrX:37027200A>C	uc004ddl.1	+	1	731	c.717A>C	c.(715-717)CCA>CCC	p.P239P		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	239										ovary(3)	3						TGGAGCCTCCAGAGACTGGAG	0.637		NaN											0	0	0	0.004672	0	3	71									
HUWE1	10075	broad.mit.edu	37	X	53617425	53617425	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chrX:53617425C>G	uc004dsp.2	-	35	4532	c.4130G>C	c.(4129-4131)AGA>ACA	p.R1377T	HUWE1_uc004dsn.2_Missense_Mutation_p.R202T	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	1377	UIM.				base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						AGCAATTGCTCTCATCATCTG	0.443		NaN											0	0	0	0.01441	0	103	9									
OTUD6A	139562	broad.mit.edu	37	X	69282408	69282408	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chrX:69282408C>G	uc004dxu.1	+	1	68	c.34C>G	c.(34-36)CTG>GTG	p.L12V		NM_207320	NP_997203	Q7L8S5	OTU6A_HUMAN	OTU domain containing 6A	12										lung(1)|skin(1)	2						GCAGCGCATACTGCGCCGCCA	0.532		NaN											0	0	0	0.004672	0	3	10									
BRWD3	254065	broad.mit.edu	37	X	79936980	79936980	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chrX:79936980C>G	uc004edt.2	-	40	4777	c.4514G>C	c.(4513-4515)GGG>GCG	p.G1505A	BRWD3_uc010nmi.1_RNA|BRWD3_uc004edo.2_Missense_Mutation_p.G1101A|BRWD3_uc004edp.2_Missense_Mutation_p.G1334A|BRWD3_uc004edq.2_Missense_Mutation_p.G1101A|BRWD3_uc010nmj.1_Missense_Mutation_p.G1101A|BRWD3_uc004edr.2_Missense_Mutation_p.G1175A|BRWD3_uc004eds.2_Missense_Mutation_p.G1101A|BRWD3_uc004edu.2_Missense_Mutation_p.G1175A|BRWD3_uc004edv.2_Missense_Mutation_p.G1101A|BRWD3_uc004edw.2_Missense_Mutation_p.G1101A|BRWD3_uc004edx.2_Missense_Mutation_p.G1101A|BRWD3_uc004edy.2_Missense_Mutation_p.G1101A|BRWD3_uc004edz.2_Missense_Mutation_p.G1175A|BRWD3_uc004eea.2_Missense_Mutation_p.G1175A|BRWD3_uc004eeb.2_Missense_Mutation_p.G1101A	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	1505										ovary(4)	4						TAGTGAAAGCCCTTCAGCAGC	0.373		NaN											0	0	0	0.000602	0	5	33									
PCDH19	57526	broad.mit.edu	37	X	99663097	99663097	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chrX:99663097C>G	uc010nmz.2	-	1	2175	c.499G>C	c.(499-501)GAG>CAG	p.E167Q	PCDH19_uc004efw.3_Missense_Mutation_p.E167Q|PCDH19_uc004efx.3_Missense_Mutation_p.E167Q	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	167	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						GGCGTGAGCTCGTAAGTCTGC	0.637		NaN											0	0	0	0.005524	0	39	5									
MORC4	79710	broad.mit.edu	37	X	106243186	106243186	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chrX:106243186C>T	uc004emu.3	-	1	257	c.14G>A	c.(13-15)CGA>CAA	p.R5Q	MORC4_uc004emv.3_Missense_Mutation_p.R5Q|MORC4_uc004emw.3_5'UTR	NM_024657	NP_078933	Q8TE76	MORC4_HUMAN	zinc finger, CW type with coiled-coil domain 2	5							ATP binding|zinc ion binding			ovary(1)	1						gggggccccTCGGTACAGGAG	0.448		NaN											0	0	0	0.00308	0	6	0									
BCORL1	63035	broad.mit.edu	37	X	129149373	129149373	+	Silent	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chrX:129149373C>G	uc004evb.1	+	4	2739	c.2625C>G	c.(2623-2625)CTC>CTG	p.L875L	BCORL1_uc010nrd.1_Silent_p.L777L	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	875					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						TGCCATCTCTCAGCTCCAGCG	0.602		NaN											0	0	0	0.000602	0	5	30									
BCORL1	63035	broad.mit.edu	37	X	129149590	129149590	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chrX:129149590C>T	uc004evb.1	+	4	2956	c.2842C>T	c.(2842-2844)CAG>TAG	p.Q948*	BCORL1_uc010nrd.1_Nonsense_Mutation_p.Q850*	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	948					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						TCGAATGAATCAGGGGCCTGA	0.567		NaN											0	0	0	0.006214	0	8	49									
ENOX2	10495	broad.mit.edu	37	X	129790591	129790591	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chrX:129790591C>G	uc004evw.2	-	11	1598	c.1180G>C	c.(1180-1182)GAA>CAA	p.E394Q	ENOX2_uc004evx.2_Missense_Mutation_p.E365Q|ENOX2_uc004evy.2_Missense_Mutation_p.E365Q|ENOX2_uc004evv.2_Missense_Mutation_p.E221Q	NM_182314	NP_872114	Q16206	ENOX2_HUMAN	ecto-NOX disulfide-thiol exchanger 2 isoform b	394	Potential.				cell growth|electron transport chain|regulation of growth|transport|ultradian rhythm	cytosol|external side of plasma membrane|extracellular space	nucleic acid binding|nucleotide binding|protein disulfide oxidoreductase activity			ovary(1)	1						GTCATTTCTTCTATTTCATCA	0.269		NaN											0	0	0	0.01441	0	46	4									
CNGA2	1260	broad.mit.edu	37	X	150911830	150911830	+	Silent	SNP	C	C	A			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chrX:150911830C>A	uc004fey.1	+	7	1079	c.855C>A	c.(853-855)ATC>ATA	p.I285I		NM_005140	NP_005131	Q16280	CNGA2_HUMAN	cyclic nucleotide gated channel alpha 2	285	Helical; Name=H4; (Potential).				response to stimulus|sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TCTTGGTCATCATCCACTGGA	0.493		NaN											1	0	3.13773e-49	0.01441	3.40063e-49	111	22									
F8	2157	broad.mit.edu	37	X	154227805	154227805	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chrX:154227805C>G	uc004fmt.2	-	2	385	c.214G>C	c.(214-216)GAA>CAA	p.E72Q	F8_uc011mzx.1_Missense_Mutation_p.E37Q	NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	72	Plastocyanin-like 1.|F5/8 type A 1.		E -> K (in HEMA; moderate).		acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TCCGTGAATTCTACAAACAGA	0.388		NaN											0	0	0	0.007291	0	23	91									
SPEN	23013	broad.mit.edu	37	1	16262459	16262460	+	Frame_Shift_Ins	INS	-	-	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:16262459_16262460insC	uc001axk.1	+	11	9928_9929	c.9724_9725insC	c.(9724-9726)GCCfs	p.A3242fs	SPEN_uc010obp.1_Frame_Shift_Ins_p.A3201fs	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	3242	Pro-rich.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		TGCCAAAGCTgcccccaccccc	0.431		NaN											NaN	NaN	NaN	NaN	NaN	8	59	---	---							
INTS7	25896	broad.mit.edu	37	1	212115191	212115193	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:212115191_212115193delTGC	uc001hiw.1	-	20	2967_2969	c.2862_2864delGCA	c.(2860-2865)CAGCAA>CAA	p.954_955QQ>Q	INTS7_uc009xdb.1_In_Frame_Del_p.934_935QQ>Q|INTS7_uc001hix.1_In_Frame_Del_p.830_831QQ>Q|INTS7_uc001hiy.1_In_Frame_Del_p.940_941QQ>Q|INTS7_uc010pta.1_In_Frame_Del_p.905_906QQ>Q	NM_015434	NP_056249	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	954_955	Gln-rich.				snRNA processing	integrator complex	protein binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		GGCATTGCGTTGCTGCTGCTGCT	0.443		NaN											NaN	NaN	NaN	NaN	NaN	9	353	---	---							
CUBN	8029	broad.mit.edu	37	10	17145185	17145185	+	Frame_Shift_Del	DEL	G	G	-			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr10:17145185delG	uc001ioo.2	-	13	1521	c.1469delC	c.(1468-1470)CCGfs	p.P490fs		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	490	CUB 1.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ACCAACATCCGGGCTCCTGTA	0.398		NaN											NaN	NaN	NaN	NaN	NaN	45	73	---	---							
TMEM126A	84233	broad.mit.edu	37	11	85366703	85366704	+	Frame_Shift_Ins	INS	-	-	TA			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr11:85366703_85366704insTA	uc001par.2	+	4	442_443	c.346_347insTA	c.(346-348)CTAfs	p.L116fs		NM_032273	NP_115649	Q9H061	T126A_HUMAN	transmembrane protein 126A	116	Helical; (Potential).					integral to membrane|mitochondrion				ovary(2)	2		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				TATTGGTGGTCTATACCCTGTT	0.366		NaN											NaN	NaN	NaN	NaN	NaN	84	231	---	---							
BAZ2A	11176	broad.mit.edu	37	12	56999009	56999010	+	Frame_Shift_Ins	INS	-	-	CA			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:56999009_56999010insCA	uc001slq.1	-	14	2795_2796	c.2601_2602insTG	c.(2599-2604)GTGCTGfs	p.V867fs	BAZ2A_uc001slp.1_Frame_Shift_Ins_p.V865fs|BAZ2A_uc009zov.1_5'Flank|BAZ2A_uc009zow.1_Frame_Shift_Ins_p.V835fs	NM_013449	NP_038477	Q9UIF9	BAZ2A_HUMAN	bromodomain adjacent to zinc finger domain, 2A	867_868	DDT.				chromatin silencing at rDNA|DNA methylation|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	DNA binding|histone acetyl-lysine binding|ligand-dependent nuclear receptor binding|RNA binding|zinc ion binding				0						TCAAAGCCCAGCACCTTGCCAA	0.574		NaN											NaN	NaN	NaN	NaN	NaN	25	33	---	---							
UNKL	64718	broad.mit.edu	37	16	1464642	1464643	+	Frame_Shift_Ins	INS	-	-	G			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr16:1464642_1464643insG	uc010bro.1	-	1	58_59	c.50_51insC	c.(49-51)CCGfs	p.P17fs	UNKL_uc002clq.2_Frame_Shift_Ins_p.P17fs	NM_001037125	NP_001032202	Q9H9P5	UNKL_HUMAN	unkempt homolog (Drosophila)-like isoform 2	17						cytoplasm|nucleus	ligase activity|nucleic acid binding|zinc ion binding				0		Hepatocellular(780;0.0893)				TCTCAGTCTGCGGGGGGGACCC	0.332		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---	---							
ARFGAP3	26286	broad.mit.edu	37	22	43213780	43213780	+	Frame_Shift_Del	DEL	T	T	-			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr22:43213780delT	uc003bdd.2	-	10	1116	c.896delA	c.(895-897)AATfs	p.N299fs	ARFGAP3_uc010gzf.2_Frame_Shift_Del_p.N255fs|ARFGAP3_uc011apu.1_Frame_Shift_Del_p.N227fs	NM_014570	NP_055385	Q9NP61	ARFG3_HUMAN	ADP-ribosylation factor GTPase activating	299					intracellular protein transport|protein secretion|regulation of ARF GTPase activity|vesicle-mediated transport	cytosol|Golgi membrane	ARF GTPase activator activity|protein transporter activity|zinc ion binding			breast(1)	1						TGAGTCAACATTTTTTTTGCC	0.224		NaN											NaN	NaN	NaN	NaN	NaN	7	184	---	---							
UCP1	7350	broad.mit.edu	37	4	141489036	141489036	+	Frame_Shift_Del	DEL	G	G	-	rs17848358		TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr4:141489036delG	uc011chj.1	-	2	298	c.222delC	c.(220-222)CTCfs	p.L74fs	UCP1_uc011chk.1_Frame_Shift_Del_p.L74fs	NM_021833	NP_068605	P25874	UCP1_HUMAN	uncoupling protein 1	74	Solcar 1.|Helical; Name=2; (Potential).				brown fat cell differentiation|cellular lipid metabolic process|respiratory electron transport chain	integral to membrane|mitochondrial inner membrane	binding			ovary(1)	1	all_hematologic(180;0.162)					GCCCGCTGTAGAGTTTCATCC	0.567		NaN											NaN	NaN	NaN	NaN	NaN	71	90	---	---							
CDKN1A	1026	broad.mit.edu	37	6	36652112	36652113	+	Frame_Shift_Ins	INS	-	-	C			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08			-	C	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr6:36652112_36652113insC	uc003omm.3	+	2	356_357	c.234_235insC	c.(232-237)CTTCCCfs	p.L78fs	CDKN1A_uc011dtq.1_Frame_Shift_Ins_p.L112fs|CDKN1A_uc003oml.2_Frame_Shift_Ins_p.L78fs|CDKN1A_uc003omn.2_Frame_Shift_Ins_p.L78fs	NM_000389	NP_000380	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A	78_79					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			ovary(1)|breast(1)	2						AGCTCTACCTTCCCACGGGGCC	0.663		NaN							Multiple_Endocrine_Neoplasia_type_1				NaN	NaN	NaN	NaN	NaN	29	7	---	---							
KCNV1	27012	broad.mit.edu	37	8	110984590	110984593	+	Frame_Shift_Del	DEL	ACTT	ACTT	-			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr8:110984590_110984593delACTT	uc003ynr.3	-	2	1227_1230	c.885_888delAAGT	c.(883-888)CTAAGTfs	p.L295fs	KCNV1_uc010mcw.2_Frame_Shift_Del_p.L295fs	NM_014379	NP_055194	Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	295_296	Helical; Name=Segment S3; (Potential).					voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			lung(1)|kidney(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			TCTGGCTCCCACTTAGGCTCTCTA	0.559		NaN											NaN	NaN	NaN	NaN	NaN	21	62	---	---							
RUSC2	9853	broad.mit.edu	37	9	35560363	35560363	+	Frame_Shift_Del	DEL	G	G	-			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:35560363delG	uc003zww.2	+	10	3981	c.3726delG	c.(3724-3726)GAGfs	p.E1242fs	RUSC2_uc010mkq.2_RNA|RUSC2_uc003zwx.3_Frame_Shift_Del_p.E1242fs	NM_014806	NP_055621	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	1242	Poly-Glu.					cytosol				ovary(1)	1			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			aagaggaagaggaagaagagg	0.547		NaN											NaN	NaN	NaN	NaN	NaN	8	16	---	---