Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
RNF207	388591	broad.mit.edu	37	1	6270478	6270478	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:6270478G>C	uc001amg.2	+	10	1096	c.922G>C	c.(922-924)GAG>CAG	p.E308Q	RNF207_uc001amh.2_Nonstop_Mutation_p.*196S|RNF207_uc010nzp.1_RNA	NM_207396	NP_997279	Q6ZRF8	RN207_HUMAN	ring finger protein 207	308						intracellular	zinc ion binding				0	Ovarian(185;0.0634)	all_cancers(23;1.22e-38)|all_epithelial(116;4.25e-22)|all_lung(118;7.95e-08)|Lung NSC(185;1.6e-06)|all_neural(13;3.18e-06)|all_hematologic(16;8.99e-06)|Acute lymphoblastic leukemia(12;0.000365)|Breast(487;0.000496)|Renal(390;0.0007)|Colorectal(325;0.00104)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)|Medulloblastoma(700;0.211)		Epithelial(90;4.84e-38)|GBM - Glioblastoma multiforme(13;5.77e-32)|OV - Ovarian serous cystadenocarcinoma(86;2.88e-19)|Colorectal(212;6.9e-08)|COAD - Colon adenocarcinoma(227;8.13e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.00311)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.182)		CAACAAGGCTGAGTTCCTGGA	0.647		NaN											0	0	0	0.00308	0	6	109									
APITD1	378708	broad.mit.edu	37	1	10500432	10500432	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:10500432G>A	uc001are.2	+	4	654	c.238G>A	c.(238-240)GAA>AAA	p.E80K	APITD1_uc001arf.2_Missense_Mutation_p.E80K|APITD1_uc001arg.2_Intron|APITD1_uc001arh.2_Missense_Mutation_p.E41K	NM_199294	NP_954988	Q8N2Z9	CENPS_HUMAN	apoptosis-inducing, TAF9-like domain 1 isoform	80					DNA repair|mitotic prometaphase|transcription initiation, DNA-dependent	chromosome, centromeric region|cytosol|Fanconi anaemia nuclear complex	chromatin binding|DNA binding|protein binding			ovary(1)	1	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.31e-07)|COAD - Colon adenocarcinoma(227;7.32e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000297)|Kidney(185;0.000747)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0487)		AATTAACACTGAAGATGTGAA	0.393		NaN											0	0	0	0.001984	0	4	65									
FBXO2	26232	broad.mit.edu	37	1	11708827	11708827	+	Missense_Mutation	SNP	C	C	G	rs149264736		TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:11708827C>G	uc001asj.2	-	6	1157	c.815G>C	c.(814-816)GGG>GCG	p.G272A	FBXO2_uc009vna.2_Missense_Mutation_p.G275A	NM_012168	NP_036300	Q9UK22	FBX2_HUMAN	F-box only protein 2	272	FBA.				glycoprotein catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|endoplasmic reticulum|membrane|microsome|SCF ubiquitin ligase complex	sugar binding|ubiquitin-protein ligase activity				0	Ovarian(185;0.249)	Lung NSC(185;9.37e-06)|all_lung(284;1.39e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|BRCA - Breast invasive adenocarcinoma(304;1.88e-06)|Colorectal(212;4.88e-06)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|Lung(427;0.0146)|LUSC - Lung squamous cell carcinoma(448;0.0228)|READ - Rectum adenocarcinoma(331;0.0649)		GTCCTGCCCCCCGTGCTCGAA	0.667		NaN											0	0	0	0.000978	0	9	127									
TMEM82	388595	broad.mit.edu	37	1	16074093	16074093	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:16074093C>T	uc001axc.2	+	6	1136	c.998C>T	c.(997-999)TCG>TTG	p.S333L		NM_001013641	NP_001013663	A0PJX8	TMM82_HUMAN	transmembrane protein 82	333						integral to membrane				breast(1)|central_nervous_system(1)	2		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.73e-07)|COAD - Colon adenocarcinoma(227;3.49e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000114)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CCCCTGCCCTCGGCACCCCAG	0.607		NaN											0	0	0	0.000602	0	5	134									
CROCC	9696	broad.mit.edu	37	1	17265447	17265447	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:17265447C>G	uc001azt.2	+	12	1487	c.1418C>G	c.(1417-1419)TCT>TGT	p.S473C	CROCC_uc009voy.1_Missense_Mutation_p.S176C|CROCC_uc009voz.1_Missense_Mutation_p.S236C|CROCC_uc001azu.2_5'Flank	NM_014675	NP_055490	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil	473					cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			ovary(2)|breast(2)|central_nervous_system(1)	5		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		CTGAGCGGCTCTGAGCGCACC	0.711		NaN											0	0	0	0.008291	0	6	109									
PADI2	11240	broad.mit.edu	37	1	17410286	17410286	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:17410286C>G	uc001baf.2	-	9	1067	c.985G>C	c.(985-987)GAG>CAG	p.E329Q	PADI2_uc010ocm.1_Missense_Mutation_p.E213Q|PADI2_uc001bag.1_Missense_Mutation_p.E329Q	NM_007365	NP_031391	Q9Y2J8	PADI2_HUMAN	peptidyl arginine deiminase, type II	329					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			ovary(3)|pancreas(1)|central_nervous_system(1)|skin(1)	6		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000422)|Renal(390;0.000518)|all_lung(284;0.000546)|Ovarian(437;0.00671)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;1.49e-05)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)	L-Citrulline(DB00155)	TTGGTTTTCTCCACAAGGTTC	0.542		NaN											0	0	0	0.001855	0	11	124									
TMEM57	55219	broad.mit.edu	37	1	25824881	25824881	+	Missense_Mutation	SNP	A	A	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:25824881A>G	uc001bkk.2	+	11	2121	c.1919A>G	c.(1918-1920)TAC>TGC	p.Y640C	TMEM57_uc009vru.2_Missense_Mutation_p.Y413C|TMEM57_uc009vrv.2_Missense_Mutation_p.Y282C	NM_018202	NP_060672	Q8N5G2	MACOI_HUMAN	transmembrane protein 57	640						axon|integral to membrane|neuron projection terminus|nuclear membrane|synapse part					0		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00715)|all_lung(284;0.00989)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0675)|all_neural(195;0.201)		UCEC - Uterine corpus endometrioid carcinoma (279;0.042)|OV - Ovarian serous cystadenocarcinoma(117;1.85e-26)|Colorectal(126;2.99e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|STAD - Stomach adenocarcinoma(196;0.000766)|BRCA - Breast invasive adenocarcinoma(304;0.000986)|GBM - Glioblastoma multiforme(114;0.0191)|READ - Rectum adenocarcinoma(331;0.0649)		TCCCCCCACTACTCTTCCAAA	0.542		NaN											0	0	0	0.007413	0	16	147									
RCC1	1104	broad.mit.edu	37	1	28863401	28863401	+	Silent	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:28863401G>A	uc001bqg.1	+	9	1165	c.1080G>A	c.(1078-1080)GTG>GTA	p.V360V	SNHG3-RCC1_uc001bqa.1_Silent_p.V360V|SNHG3-RCC1_uc001bqb.1_Silent_p.V360V|SNHG3-RCC1_uc001bqc.1_Silent_p.V360V|RCC1_uc001bqe.1_Silent_p.V377V|RCC1_uc001bqf.1_Silent_p.V391V	NM_001269	NP_001260	P18754	RCC1_HUMAN	regulator of chromosome condensation 1 isoform	360	RCC1 6.				cell division|chromosome segregation|G1/S transition of mitotic cell cycle|mitosis|mitotic spindle organization|regulation of mitosis|regulation of S phase of mitotic cell cycle|spindle assembly|viral reproduction	condensed nuclear chromosome|cytoplasm|nuclear chromatin|nuclear membrane|nucleoplasm	histone binding|nucleosomal DNA binding|Ran guanyl-nucleotide exchange factor activity			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000318)|all_lung(284;0.000434)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.00989)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|KIRC - Kidney renal clear cell carcinoma(1967;0.0101)|BRCA - Breast invasive adenocarcinoma(304;0.022)|READ - Rectum adenocarcinoma(331;0.0649)		GGTATGCTGTGACCAAGGATG	0.587		NaN											0	0	0	0.00333	0	21	344									
INPP5B	3633	broad.mit.edu	37	1	38397639	38397639	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:38397639G>A	uc001ccg.1	-	7	572	c.478C>T	c.(478-480)CGC>TGC	p.R160C	INPP5B_uc009vvk.1_Missense_Mutation_p.R101C|INPP5B_uc001cch.2_Missense_Mutation_p.R101C|INPP5B_uc001ccf.1_5'Flank	NM_005540	NP_005531	P32019	I5P2_HUMAN	inositol polyphosphate-5-phosphatase, 75kDa	160					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to membrane|microtubule cytoskeleton	GTPase activator activity|inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			urinary_tract(1)	1	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				TTACAACCGCGCGGCGTTGGC	0.612		NaN											0	0	0	0.000602	0	5	101									
MFSD2A	84879	broad.mit.edu	37	1	40432551	40432551	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:40432551G>A	uc001cev.2	+	8	1094	c.913G>A	c.(913-915)GGC>AGC	p.G305S	MFSD2A_uc010ojb.1_Missense_Mutation_p.G253S|MFSD2A_uc001ceu.2_Missense_Mutation_p.G292S|MFSD2A_uc010ojc.1_Missense_Mutation_p.G136S|MFSD2A_uc009vvy.2_RNA|MFSD2A_uc001cex.2_5'Flank	NM_001136493	NP_001129965	Q8NA29	MFS2A_HUMAN	major facilitator superfamily domain containing	305					transmembrane transport	endoplasmic reticulum membrane|integral to membrane				ovary(1)|pancreas(1)	2						CATGAGCCACGGCCCATACAT	0.562		NaN											0	0	0	0.00245	0	12	188									
CAP1	10487	broad.mit.edu	37	1	40536608	40536608	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:40536608C>T	uc001cfa.3	+	12	1530	c.1301C>T	c.(1300-1302)TCT>TTT	p.S434F	CAP1_uc001cey.3_Missense_Mutation_p.S434F|CAP1_uc001cez.3_Missense_Mutation_p.S434F|CAP1_uc009vvz.2_Missense_Mutation_p.S434F|CAP1_uc010oje.1_Missense_Mutation_p.S351F	NM_006367	NP_006358	Q01518	CAP1_HUMAN	adenylyl cyclase-associated protein	434	C-CAP/cofactor C-like.				activation of adenylate cyclase activity|axon guidance|establishment or maintenance of cell polarity|platelet activation|platelet degranulation|signal transduction	plasma membrane	actin binding			ovary(1)	1	Lung NSC(20;5.03e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;4.63e-18)|Epithelial(16;1.27e-16)|all cancers(16;2.3e-15)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AGTGCCAAATCTTCCGAGATG	0.408		NaN											0	0	0	0.001368	0	10	179									
ZNF643	65243	broad.mit.edu	37	1	40928137	40928137	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:40928137G>C	uc001cfn.1	+	5	778	c.481G>C	c.(481-483)GAT>CAT	p.D161H	ZNF643_uc001cfl.1_Missense_Mutation_p.D59H|ZNF643_uc001cfm.1_Missense_Mutation_p.D27H	NM_023070	NP_075558	Q9UJL9	ZN643_HUMAN	zinc finger protein 643	161					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;5.25e-18)			CTTACAGAATGATATTTCGTG	0.323		NaN											0	0	0	0.003163	0	15	162									
B4GALT2	8704	broad.mit.edu	37	1	44450629	44450629	+	Silent	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:44450629C>T	uc001clg.2	+	4	1012	c.642C>T	c.(640-642)TTC>TTT	p.F214F	B4GALT2_uc001clh.2_Silent_p.F148F|B4GALT2_uc010okl.1_Silent_p.F243F|B4GALT2_uc001cli.2_Silent_p.F214F	NM_003780	NP_003771	O60909	B4GT2_HUMAN	UDP-Gal:betaGlcNAc beta 1,4-	214	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|lactose synthase activity|metal ion binding|N-acetyllactosamine synthase activity			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			N-Acetyl-D-glucosamine(DB00141)	GCTTCATCTTCAGCGATGTGG	0.587		NaN											0	0	0	0.001168	0	5	108									
AKR1A1	10327	broad.mit.edu	37	1	46027485	46027485	+	Silent	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:46027485C>T	uc001cod.2	+	3	483	c.19C>T	c.(19-21)CTA>TTA	p.L7L	AKR1A1_uc009vxw.2_Silent_p.L7L|AKR1A1_uc001coe.2_Silent_p.L7L	NM_006066	NP_006057	P14550	AK1A1_HUMAN	aldo-keto reductase family 1, member A1	7					glucose metabolic process		alditol:NADP+ 1-oxidoreductase activity|electron carrier activity|protein binding				0	Acute lymphoblastic leukemia(166;0.155)					TTCCTGTGTTCTACTGCACAC	0.502		NaN											0	0	0	0.003163	0	10	129									
POMGNT1	55624	broad.mit.edu	37	1	46661728	46661728	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:46661728C>T	uc001cpe.2	-	5	540	c.376G>A	c.(376-378)GAG>AAG	p.E126K	POMGNT1_uc010olx.1_Missense_Mutation_p.E104K|POMGNT1_uc010oly.1_RNA|POMGNT1_uc010olz.1_5'UTR|POMGNT1_uc001cpg.2_Missense_Mutation_p.E126K|POMGNT1_uc001cpf.2_5'UTR|POMGNT1_uc001cpj.2_Missense_Mutation_p.E110K	NM_017739	NP_060209	Q8WZA1	PMGT1_HUMAN	O-linked mannose	126	Lumenal (Potential).				protein N-linked glycosylation|protein O-linked glycosylation	Golgi membrane|integral to membrane|microsome	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					CGGCCCTGCTCCCGGGCCTCA	0.572		NaN											0	0	0	0.001168	0	6	90									
LRRC41	10489	broad.mit.edu	37	1	46744891	46744891	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:46744891C>T	uc001cpn.2	-	9	2226	c.2182G>A	c.(2182-2184)GAG>AAG	p.E728K	LRRC41_uc010omb.1_3'UTR	NM_006369	NP_006360	Q15345	LRC41_HUMAN	MUF1 protein	728	LRR 6.									ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(166;0.155)					GATGAATCCTCTGAGAAAACA	0.542		NaN											0	0	0	0.00308	0	6	44									
DMRTB1	63948	broad.mit.edu	37	1	53927289	53927289	+	Missense_Mutation	SNP	T	T	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:53927289T>C	uc001cvq.1	+	2	776	c.721T>C	c.(721-723)TCC>CCC	p.S241P		NM_033067	NP_149056	Q96MA1	DMRTB_HUMAN	DMRT-like family B with proline-rich C-terminal,	241	Pro-rich.				sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						CCGGCATGTGTCCCGCAGCCA	0.662		NaN											0	0	0	0.000602	0	4	73									
LRRC7	57554	broad.mit.edu	37	1	70503871	70503871	+	Silent	SNP	T	T	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:70503871T>C	uc001dep.2	+	19	2280	c.2250T>C	c.(2248-2250)AAT>AAC	p.N750N	LRRC7_uc009wbg.2_Silent_p.N34N|LRRC7_uc001deq.2_5'UTR	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	750						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						CCCCAGGCAATATACCACAGC	0.502		NaN											0	0	0	0.007835	0	37	189									
GBP5	115362	broad.mit.edu	37	1	89730587	89730587	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:89730587C>G	uc001dnc.2	-	8	1468	c.931G>C	c.(931-933)GAG>CAG	p.E311Q	GBP5_uc001dnd.2_Missense_Mutation_p.E311Q|GBP5_uc001dne.1_Missense_Mutation_p.E311Q	NM_052942	NP_443174	Q96PP8	GBP5_HUMAN	guanylate-binding protein 5	311						plasma membrane	GTP binding|GTPase activity			ovary(1)	1				all cancers(265;0.00784)|Epithelial(280;0.0286)		ACTGCATTCTCTATGCAAGGC	0.483		NaN											0	0	0	0.001855	0	10	78									
EPHX4	253152	broad.mit.edu	37	1	92515897	92515897	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:92515897C>T	uc001don.2	+	5	732	c.628C>T	c.(628-630)CAG>TAG	p.Q210*		NM_173567	NP_775838	Q8IUS5	EPHX4_HUMAN	abhydrolase domain containing 7	210						integral to membrane	hydrolase activity			central_nervous_system(1)	1						ACACCCTGCTCAGCTGTTGAA	0.328		NaN											0	0	0	0.001168	0	6	104									
MAGI3	260425	broad.mit.edu	37	1	114128166	114128166	+	Silent	SNP	T	T	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:114128166T>G	uc001edk.2	+	4	892	c.711T>G	c.(709-711)CCT>CCG	p.P237P	MAGI3_uc001edh.3_Silent_p.P237P|MAGI3_uc001edi.3_Silent_p.P237P|MAGI3_uc010owm.1_Silent_p.P237P	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	237	Guanylate kinase-like.				apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCTCTCTTCCTGAAGAGGAAG	0.383		NaN											0	0	0	0.001368	0	11	57									
TBX15	6913	broad.mit.edu	37	1	119427557	119427557	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:119427557C>T	uc001ehl.1	-	8	1604	c.1289G>A	c.(1288-1290)AGC>AAC	p.S430N	TBX15_uc009whj.1_Missense_Mutation_p.S254N	NM_152380	NP_689593	Q96SF7	TBX15_HUMAN	T-box 15	536						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|pancreas(1)	2	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		TTGAGAGGCGCTCAGTTTTTC	0.522		NaN											0	0	0	0.000602	0	4	43									
ANKRD35	148741	broad.mit.edu	37	1	145561190	145561190	+	Missense_Mutation	SNP	C	C	T	rs80055280	by1000genomes	TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:145561190C>T	uc001eob.1	+	10	986	c.878C>T	c.(877-879)CCG>CTG	p.P293L	NBPF10_uc001emp.3_Intron|ANKRD35_uc010oyx.1_Missense_Mutation_p.P136L	NM_144698	NP_653299	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	293										ovary(4)|skin(1)	5	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GATGAAGACCCGTGCTCGGAG	0.547		NaN											0	0	0	0.001984	0	6	49									
PLEKHO1	51177	broad.mit.edu	37	1	150131673	150131673	+	Silent	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:150131673C>G	uc001ett.2	+	6	1463	c.1185C>G	c.(1183-1185)CTC>CTG	p.L395L	PLEKHO1_uc001etr.2_Silent_p.L223L|PLEKHO1_uc001ets.2_Silent_p.L212L|PLEKHO1_uc001etu.2_Silent_p.L223L	NM_016274	NP_057358	Q53GL0	PKHO1_HUMAN	pleckstrin homology domain containing, family O	395	Negative regulator of AP-1 activity.					cytoplasm|nucleus|plasma membrane				lung(1)	1	Lung NSC(24;7.78e-28)|Breast(34;0.00211)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			ACTCCCACCTCAGACAGACCA	0.587		NaN											0	0	0	0.008291	0	8	41									
C1orf54	79630	broad.mit.edu	37	1	150248191	150248191	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:150248191G>C	uc001eud.2	+	3	210	c.172G>C	c.(172-174)GAG>CAG	p.E58Q	C1orf54_uc001euc.2_Missense_Mutation_p.E58Q|C1orf54_uc001eue.2_Missense_Mutation_p.E58Q|C1orf54_uc001euf.2_Missense_Mutation_p.E58Q|C1orf54_uc001eug.2_Missense_Mutation_p.E58Q	NM_024579	NP_078855	Q8WWF1	CA054_HUMAN	hypothetical protein LOC79630 precursor	58						extracellular region					0	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			CTCCATATTTGAGTCAGAGGA	0.294		NaN											0	0	0	0.008291	0	9	78									
BNIPL	149428	broad.mit.edu	37	1	151015476	151015476	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:151015476G>A	uc001ewl.2	+	5	651	c.478G>A	c.(478-480)GAA>AAA	p.E160K	BNIPL_uc009wmi.2_Missense_Mutation_p.E78K|BNIPL_uc009wmj.2_RNA	NM_138278	NP_612122	Q7Z465	BNIPL_HUMAN	BCL2/adenovirus E1B 19kD interacting protein	160					apoptosis|induction of apoptosis|negative regulation of cell proliferation|regulation of growth rate	cytosol|nucleus	identical protein binding				0	Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TGAGACAGCTGAAAGGCTGGG	0.517		NaN											0	0	0	0.003163	0	14	169									
BNIPL	149428	broad.mit.edu	37	1	151015532	151015532	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:151015532G>A	uc001ewl.2	+	5	707	c.534G>A	c.(532-534)TGG>TGA	p.W178*	BNIPL_uc009wmi.2_Nonsense_Mutation_p.W96*|BNIPL_uc009wmj.2_RNA	NM_138278	NP_612122	Q7Z465	BNIPL_HUMAN	BCL2/adenovirus E1B 19kD interacting protein	178					apoptosis|induction of apoptosis|negative regulation of cell proliferation|regulation of growth rate	cytosol|nucleus	identical protein binding				0	Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GACATCACTGGAGGGTGTTCC	0.542		NaN											0	0	0	0.006214	0	7	113									
BNIPL	149428	broad.mit.edu	37	1	151015865	151015865	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:151015865G>A	uc001ewl.2	+	6	847	c.674G>A	c.(673-675)AGA>AAA	p.R225K	BNIPL_uc009wmi.2_Missense_Mutation_p.R143K|BNIPL_uc009wmj.2_RNA	NM_138278	NP_612122	Q7Z465	BNIPL_HUMAN	BCL2/adenovirus E1B 19kD interacting protein	225	CRAL-TRIO.				apoptosis|induction of apoptosis|negative regulation of cell proliferation|regulation of growth rate	cytosol|nucleus	identical protein binding				0	Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TATCTACCCAGAAGCAGCATC	0.463		NaN											0	0	0	0.008361	0	25	432									
TMOD4	29765	broad.mit.edu	37	1	151147246	151147246	+	Missense_Mutation	SNP	G	G	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:151147246G>T	uc001exc.3	-	2	296	c.106C>A	c.(106-108)CAG>AAG	p.Q36K	TMOD4_uc001exb.2_5'Flank|TMOD4_uc001exd.2_RNA|TMOD4_uc010pct.1_Missense_Mutation_p.Q36K	NM_013353	NP_037485	Q9NZQ9	TMOD4_HUMAN	tropomodulin 4 (muscle)	36					muscle contraction	cytoplasm|cytoskeleton	actin binding|tropomyosin binding			ovary(1)	1	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TCCATCTCCTGTAGTTCGCAG	0.532		NaN											1	0	0.00024832	0.009096	0.000257078	4	46									
FLG	2312	broad.mit.edu	37	1	152282137	152282137	+	Missense_Mutation	SNP	G	G	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:152282137G>T	uc001ezu.1	-	3	5261	c.5225C>A	c.(5224-5226)CCC>CAC	p.P1742H		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1742	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGCTGATGGGGCCCAGCCTG	0.587		NaN							Ichthyosis				1	0	6.3237e-29	0.00361	7.04358e-29	50	456									
FLG	2312	broad.mit.edu	37	1	152287154	152287154	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:152287154C>G	uc001ezu.1	-	3	244	c.208G>C	c.(208-210)GAC>CAC	p.D70H	uc001ezv.2_RNA	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	70	EF-hand 2.|Potential.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCAGTGAAGTCAATTTTCTTG	0.408		NaN							Ichthyosis				0	0	0	0.001168	0	5	72									
C1orf189	388701	broad.mit.edu	37	1	154173021	154173021	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:154173021C>T	uc001fee.1	-	3	144	c.118G>A	c.(118-120)GGC>AGC	p.G40S		NM_001010979	NP_001010979	Q5VU69	CA189_HUMAN	hypothetical protein LOC388701	40											0	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)					CTTCTCTGGCCCAATGCCATT	0.507		NaN											0	0	0	0.006122	0	15	401									
UBAP2L	9898	broad.mit.edu	37	1	154234112	154234112	+	Silent	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:154234112G>A	uc001fep.3	+	24	3008	c.2841G>A	c.(2839-2841)GTG>GTA	p.V947V	UBAP2L_uc009wot.2_Silent_p.V947V|UBAP2L_uc010pek.1_Silent_p.V939V|UBAP2L_uc010pel.1_Silent_p.V957V|UBAP2L_uc010pen.1_Silent_p.V861V|UBAP2L_uc001feq.2_Silent_p.V143V|UBAP2L_uc001fer.2_Silent_p.V143V	NM_014847	NP_055662	Q14157	UBP2L_HUMAN	ubiquitin associated protein 2-like isoform a	947					binding of sperm to zona pellucida		protein binding			ovary(1)|central_nervous_system(1)	2	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			ATGTCAGTGTGAATGCATCGG	0.512		NaN											0	0	0	0.006214	0	8	205									
KCNN3	3782	broad.mit.edu	37	1	154698406	154698406	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:154698406G>A	uc001ffp.2	-	5	2001	c.1687C>T	c.(1687-1689)CAG>TAG	p.Q563*	KCNN3_uc001ffo.2_Nonsense_Mutation_p.Q258*	NM_002249	NP_002240	Q9UGI6	KCNN3_HUMAN	small conductance calcium-activated potassium	568	Calmodulin-binding (By similarity).					integral to membrane	calmodulin binding			lung(1)	1	all_lung(78;2.29e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.108)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00819)			TTGGTGAGCTGAGTGTCCATC	0.522		NaN											0	0	0	0.001855	0	10	54									
ZBTB7B	51043	broad.mit.edu	37	1	154987500	154987500	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:154987500C>T	uc001fgk.3	+	3	522	c.364C>T	c.(364-366)CTC>TTC	p.L122F	ZBTB7B_uc009wpa.2_Missense_Mutation_p.L122F|ZBTB7B_uc001fgj.3_Missense_Mutation_p.L156F|ZBTB7B_uc010peq.1_Missense_Mutation_p.L156F|ZBTB7B_uc001fgl.3_Missense_Mutation_p.L122F	NM_015872	NP_056956	O15156	ZBT7B_HUMAN	zinc finger and BTB domain containing 7B	122					cell differentiation|ectoderm development|multicellular organismal development|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding				0	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GCCAGCTGTGCTCCAGGCTGC	0.607		NaN											0	0	0	0.006214	0	6	67									
NTRK1	4914	broad.mit.edu	37	1	156845889	156845889	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:156845889C>T	uc001fqh.1	+	13	1575	c.1519C>T	c.(1519-1521)CGC>TGC	p.R507C	NTRK1_uc001fqf.1_Missense_Mutation_p.R471C|NTRK1_uc009wsi.1_Missense_Mutation_p.R206C|NTRK1_uc001fqi.1_Missense_Mutation_p.R501C|NTRK1_uc009wsk.1_Missense_Mutation_p.R504C	NM_002529	NP_002520	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	507	Cytoplasmic (Potential).				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(9)|ovary(6)|stomach(1)|central_nervous_system(1)	17	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	CCACATCAAGCGCCGGGACAT	0.602		NaN	T	TPM3|TPR|TFG	papillary thyroid					TSP Lung(10;0.080)			0	0	0	0.006122	0	14	187									
KIRREL	55243	broad.mit.edu	37	1	158063421	158063421	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:158063421G>C	uc001frn.3	+	13	1992	c.1588G>C	c.(1588-1590)GAC>CAC	p.D530H	KIRREL_uc010pib.1_Missense_Mutation_p.D430H|KIRREL_uc009wsq.2_Missense_Mutation_p.D366H|KIRREL_uc001fro.3_Missense_Mutation_p.D344H|uc001frp.2_5'Flank	NM_018240	NP_060710	Q96J84	KIRR1_HUMAN	kin of IRRE like precursor	530	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1	all_hematologic(112;0.0378)					AGGTCGCAAAGACGTGACCCT	0.607		NaN											0	0	0	0.009096	0	3	45									
CD1E	913	broad.mit.edu	37	1	158325252	158325252	+	Missense_Mutation	SNP	A	A	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:158325252A>G	uc001fse.2	+	3	757	c.518A>G	c.(517-519)AAT>AGT	p.N173S	CD1E_uc010pid.1_Missense_Mutation_p.N171S|CD1E_uc010pie.1_Missense_Mutation_p.N74S|CD1E_uc010pif.1_Intron|CD1E_uc001fsd.2_Missense_Mutation_p.N173S|CD1E_uc001fsk.2_Intron|CD1E_uc001fsj.2_Intron|CD1E_uc001fsc.2_Intron|CD1E_uc010pig.1_Intron|CD1E_uc001fsa.2_Intron|CD1E_uc001fsf.2_Missense_Mutation_p.N173S|CD1E_uc001fry.2_Missense_Mutation_p.N173S|CD1E_uc001fsg.2_Intron|CD1E_uc001fsh.2_Intron|CD1E_uc001fsi.2_Missense_Mutation_p.N173S|CD1E_uc009wsv.2_Missense_Mutation_p.N74S|CD1E_uc001frz.2_Intron|CD1E_uc009wsw.2_5'Flank	NM_030893	NP_112155	P15812	CD1E_HUMAN	CD1E antigen isoform a precursor	173					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				skin(3)	3	all_hematologic(112;0.0378)					AAAGTGCTCAATCGCTACCTA	0.498		NaN											0	0	0	0.001168	0	5	72									
OR6K3	391114	broad.mit.edu	37	1	158687408	158687408	+	Silent	SNP	C	C	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:158687408C>A	uc010pip.1	-	1	546	c.546G>T	c.(544-546)CTG>CTT	p.L182L		NM_001005327	NP_001005327	Q8NGY3	OR6K3_HUMAN	olfactory receptor, family 6, subfamily K,	182	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(112;0.0378)					CACAGAAAGGCAGTGTGGAAA	0.512		NaN											1	0	0.00198382	0.001984	0.0020327	7	114									
BLZF1	8548	broad.mit.edu	37	1	169351299	169351299	+	Splice_Site	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:169351299G>A	uc001gfx.1	+	6	1235	c.798_splice	c.e6-1	p.K266_splice	BLZF1_uc001gfy.2_Splice_Site_p.K266_splice|BLZF1_uc009wvp.1_Intron	NM_003666	NP_003657	Q9H2G9	GO45_HUMAN	basic leucine zipper nuclear factor 1						cell proliferation|Golgi organization|Golgi to plasma membrane protein transport|regulation of cell growth|regulation of transcription from RNA polymerase II promoter	Golgi lumen|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding			skin(1)	1	all_hematologic(923;0.208)					GTTCTATGCAGATTATTGGAG	0.358		NaN											0	0	0	0.010504	0	19	242									
RASAL2	9462	broad.mit.edu	37	1	178423706	178423706	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:178423706G>C	uc001glr.2	+	10	1815	c.1690G>C	c.(1690-1692)GAT>CAT	p.D564H	RASAL2_uc001glq.2_Missense_Mutation_p.D712H|RASAL2_uc009wxc.2_Missense_Mutation_p.D78H	NM_004841	NP_004832	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2 isoform 1	564					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			ovary(2)|breast(2)|large_intestine(1)	5						CCCAGGCTTTGATGGTTACAT	0.423		NaN											0	0	0	0.00308	0	8	89									
HMCN1	83872	broad.mit.edu	37	1	186094827	186094827	+	Silent	SNP	A	A	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:186094827A>G	uc001grq.1	+	82	12820	c.12591A>G	c.(12589-12591)ACA>ACG	p.T4197T	HMCN1_uc001grs.1_5'Flank	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4197	Ig-like C2-type 41.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GAATCCCCACACCAGCAATTA	0.403		NaN											0	0	0	0.000978	0	7	100									
CRB1	23418	broad.mit.edu	37	1	197390669	197390669	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:197390669G>A	uc001gtz.2	+	6	1846	c.1711G>A	c.(1711-1713)GAG>AAG	p.E571K	CRB1_uc010poz.1_Missense_Mutation_p.E502K|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.E459K|CRB1_uc010ppb.1_Missense_Mutation_p.E571K|CRB1_uc010ppc.1_RNA|CRB1_uc010ppd.1_Missense_Mutation_p.E52K|CRB1_uc001gub.1_Missense_Mutation_p.E220K	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	571	Extracellular (Potential).|Laminin G-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						GCATTTCGTGGAGGTAATATT	0.448		NaN											0	0	0	0.00308	0	6	159									
DENND1B	163486	broad.mit.edu	37	1	197641247	197641247	+	Silent	SNP	T	T	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:197641247T>G	uc001guf.3	-	5	554	c.216A>C	c.(214-216)GTA>GTC	p.V72V	DENND1B_uc010ppe.1_Silent_p.V72V|DENND1B_uc010ppf.1_RNA|DENND1B_uc001gue.3_Silent_p.V62V	NM_144977	NP_659414	Q6P3S1	DEN1B_HUMAN	DENN/MADD domain containing 1B isoform 2	72	UDENN.					clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity				0						TGTCTGTCAGTACAAAGGTAA	0.358		NaN											0	0	0	0.000978	0	9	43									
CACNA1S	779	broad.mit.edu	37	1	201061110	201061110	+	Silent	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:201061110C>T	uc001gvv.2	-	4	758	c.531G>A	c.(529-531)TCG>TCA	p.S177S		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	177	Helical; Name=S4 of repeat I; (Potential).|I.				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TAGGCACCCCCGACACCAGCC	0.612		NaN											0	0	0	0.00308	0	8	39									
USH2A	7399	broad.mit.edu	37	1	215901707	215901707	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:215901707C>T	uc001hku.1	-	61	12118	c.11731G>A	c.(11731-11733)GAG>AAG	p.E3911K		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3911	Fibronectin type-III 24.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ACAGACTCCTCTTCAATGCCA	0.448		NaN								HNSCC(13;0.011)			0	0	0	0.009096	0	4	47									
BPNT1	10380	broad.mit.edu	37	1	220240712	220240712	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:220240712G>C	uc001hma.2	-	6	578	c.406C>G	c.(406-408)CTT>GTT	p.L136V	BPNT1_uc010pug.1_Missense_Mutation_p.L81V|BPNT1_uc010puh.1_Missense_Mutation_p.L100V|BPNT1_uc001hmb.3_Missense_Mutation_p.L136V	NM_006085	NP_006076	O95861	BPNT1_HUMAN	3'(2'), 5'-bisphosphate nucleotidase 1	136					3'-phosphoadenosine 5'-phosphosulfate metabolic process|nervous system development|xenobiotic metabolic process	cytosol	3'(2'),5'-bisphosphate nucleotidase activity			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0558)		ATTCCAATAAGAACTGTTACA	0.308		NaN											0	0	0	0.001168	0	6	92									
CAPN2	824	broad.mit.edu	37	1	223959545	223959545	+	Silent	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:223959545C>T	uc001hob.3	+	19	2162	c.1938C>T	c.(1936-1938)ATC>ATT	p.I646I	CAPN2_uc010puy.1_Silent_p.I568I|CAPN2_uc001hoc.2_Silent_p.I227I	NM_001748	NP_001739	P17655	CAN2_HUMAN	calpain 2 isoform 1	646	Domain IV.				proteolysis	cytoplasm|plasma membrane				lung(3)|breast(1)|skin(1)	5				GBM - Glioblastoma multiforme(131;0.109)		ACCAAGTCATCGTTGCTCGGT	0.428		NaN											0	0	0	0.00499	0	16	221									
TMEM63A	9725	broad.mit.edu	37	1	226034879	226034879	+	Silent	SNP	C	C	T	rs138912199		TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:226034879C>T	uc001hpm.1	-	24	2536	c.2286G>A	c.(2284-2286)TCG>TCA	p.S762S		NM_014698	NP_055513	O94886	TM63A_HUMAN	transmembrane protein 63A	762						integral to membrane|lysosomal membrane	nucleotide binding			ovary(1)|breast(1)	2	Breast(184;0.197)					CTGTCCTCTCCGAGGCCAAGC	0.597		NaN											0	0	0	0.004007	0	12	198									
PARP1	142	broad.mit.edu	37	1	226564877	226564877	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:226564877C>T	uc001hqd.3	-	13	2044	c.1873G>A	c.(1873-1875)GCT>ACT	p.A625T		NM_001618	NP_001609	P09874	PARP1_HUMAN	poly (ADP-ribose) polymerase family, member 1	625					cellular response to insulin stimulus|protein ADP-ribosylation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nuclear envelope|nucleolus|transcription factor complex	DNA binding|identical protein binding|NAD+ ADP-ribosyltransferase activity|protein N-terminus binding|transcription factor binding|zinc ion binding			lung(3)|ovary(2)|breast(2)|skin(2)|upper_aerodigestive_tract(1)	10	Breast(184;0.133)			GBM - Glioblastoma multiforme(131;0.0531)		GAGTGCCAAGCGTTCCCGGTT	0.458		NaN						Direct_reversal_of_damage|PARP_enzymes_that_bind_to_DNA					0	0	0	0.00361	0	84	241									
CDC42BPA	8476	broad.mit.edu	37	1	227261689	227261689	+	Missense_Mutation	SNP	A	A	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:227261689A>G	uc001hqr.2	-	19	3554	c.2611T>C	c.(2611-2613)TTT>CTT	p.F871L	CDC42BPA_uc001hqq.2_Missense_Mutation_p.F135L|CDC42BPA_uc001hqs.2_Missense_Mutation_p.F790L|CDC42BPA_uc009xes.2_Missense_Mutation_p.F871L|CDC42BPA_uc010pvs.1_Missense_Mutation_p.F871L|CDC42BPA_uc001hqp.2_Missense_Mutation_p.F27L|CDC42BPA_uc001hqu.1_Missense_Mutation_p.F27L	NM_003607	NP_003598	Q5VT25	MRCKA_HUMAN	CDC42-binding protein kinase alpha isoform B	871					actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(6)|breast(2)|stomach(1)|ovary(1)|pancreas(1)	11		all_cancers(173;0.156)|Prostate(94;0.0792)				AGTTTCGCAAAACGACGCATT	0.378		NaN											0	0	0	0.00245	0	10	221									
NID1	4811	broad.mit.edu	37	1	236180524	236180524	+	Silent	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:236180524G>A	uc001hxo.2	-	10	2280	c.2178C>T	c.(2176-2178)ATC>ATT	p.I726I	NID1_uc009xgd.2_Intron	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	726	EGF-like 3; calcium-binding (Potential).				cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	GATTATTGCAGATTGTGTGGC	0.438		NaN											0	0	0	0.000978	0	9	208									
ZP4	57829	broad.mit.edu	37	1	238049174	238049174	+	Silent	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:238049174G>A	uc001hym.2	-	7	852	c.852C>T	c.(850-852)AGC>AGT	p.S284S	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	284	ZP.|Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			AGTAGCTGCAGCTGACATGGA	0.478		NaN											0	0	0	0.000602	0	5	68									
FMN2	56776	broad.mit.edu	37	1	240370862	240370862	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:240370862G>A	uc010pyd.1	+	5	2975	c.2750G>A	c.(2749-2751)GGA>GAA	p.G917E	FMN2_uc010pye.1_Missense_Mutation_p.G921E	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	917	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CCTCTTCCCGGAGCGGGCATA	0.657		NaN											0	0	0	0.008871	0	14	291									
OR13G1	441933	broad.mit.edu	37	1	247836307	247836307	+	Missense_Mutation	SNP	C	C	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:247836307C>A	uc001idi.1	-	1	37	c.37G>T	c.(37-39)GGC>TGC	p.G13C		NM_001005487	NP_001005487	Q8NGZ3	O13G1_HUMAN	olfactory receptor, family 13, subfamily G,	13	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TTGGTGAGGCCCAGAATAATG	0.413		NaN											1	0	1.01871e-10	0.008871	1.11723e-10	14	78									
OR6F1	343169	broad.mit.edu	37	1	247875997	247875997	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:247875997G>C	uc001idj.1	-	1	61	c.61C>G	c.(61-63)CAA>GAA	p.Q21E		NM_001005286	NP_001005286	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F,	21	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			TGAAGAGTTTGAGAACCAGGA	0.473		NaN											0	0	0	0.008871	0	16	207									
OR2T33	391195	broad.mit.edu	37	1	248436919	248436919	+	Silent	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:248436919G>A	uc010pzi.1	-	1	198	c.198C>T	c.(196-198)CTC>CTT	p.L66L		NM_001004695	NP_001004695	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T,	66	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TCATGTCCATGAGGGAAAGTT	0.547		NaN											0	0	0	0.000978	0	10	198									
OR2G6	391211	broad.mit.edu	37	1	248685808	248685808	+	Silent	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:248685808C>T	uc001ien.1	+	1	861	c.861C>T	c.(859-861)CCC>CCT	p.P287P		NM_001013355	NP_001013373	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G,	287	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTTTAAACCCCATTATCTACA	0.448		NaN											0	0	0	0.004007	0	15	45									
GDI2	2665	broad.mit.edu	37	10	5808246	5808246	+	Silent	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr10:5808246G>A	uc001iil.3	-	10	1440	c.1149C>T	c.(1147-1149)ATC>ATT	p.I383I	GDI2_uc001iim.3_Silent_p.I338I|GDI2_uc009xid.2_Silent_p.I387I	NM_001494	NP_001485	P50395	GDIB_HUMAN	GDP dissociation inhibitor 2 isoform 1	383					protein transport|small GTPase mediated signal transduction	cell surface|cytosol|membrane	protein binding|Rab GDP-dissociation inhibitor activity				0						GGAGGTCACTGATGCTAACAA	0.502		NaN											0	0	0	0.001168	0	5	93									
UPF2	26019	broad.mit.edu	37	10	11994119	11994119	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr10:11994119C>T	uc001ila.2	-	14	3454	c.2980G>A	c.(2980-2982)GAA>AAA	p.E994K	UPF2_uc001ilb.2_Missense_Mutation_p.E994K|UPF2_uc001ilc.2_Missense_Mutation_p.E994K|UPF2_uc009xiz.1_Missense_Mutation_p.E994K	NM_080599	NP_542166	Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog	994	Sufficient for interaction with EIF4A1 and EIF1.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			central_nervous_system(2)|ovary(1)	3		Renal(717;0.228)				ATGGATTCTTCCAGAGAATTA	0.368		NaN											0	0	0	0.005443	0	20	198									
MCM10	55388	broad.mit.edu	37	10	13225054	13225055	+	Missense_Mutation	DNP	GG	GG	AA			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr10:13225054_13225055GG>AA	uc001ima.2	+	8	1156_1157	c.1055_1056GG>AA	c.(1054-1056)GGG>GAA	p.G352E	MCM10_uc001imb.2_Missense_Mutation_p.G351E|MCM10_uc001imc.2_Missense_Mutation_p.G351E	NM_182751	NP_877428	Q7L590	MCM10_HUMAN	minichromosome maintenance complex component 10	352					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3						ACTGTCGTAGGGATCCTCAATG	0.46		NaN											0	0	0	0.004672	0	14	122									
C10orf111	221060	broad.mit.edu	37	10	15138479	15138479	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr10:15138479C>G	uc001inw.2	-	2	619	c.345G>C	c.(343-345)ATG>ATC	p.M115I	RPP38_uc001iny.3_5'Flank|RPP38_uc009xjm.2_5'Flank|RPP38_uc001inx.3_5'Flank	NM_153244	NP_694976	Q8N326	CJ111_HUMAN	hypothetical protein LOC221060	115	Helical; (Potential).					integral to membrane					0						GGAGGAGGCTCATTAGGTCAG	0.488		NaN											0	0	0	0.000602	0	4	65									
PIP4K2A	5305	broad.mit.edu	37	10	22830755	22830755	+	Silent	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr10:22830755G>C	uc001irl.3	-	8	1262	c.1014C>G	c.(1012-1014)GTC>GTG	p.V338V	PIP4K2A_uc010qcu.1_Silent_p.V198V	NM_005028	NP_005019	P48426	PI42A_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	338	PIPK.						1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding			ovary(1)|skin(1)	2						TAATTCCATAGACGTCGATGT	0.517		NaN											0	0	0	0.004482	0	6	88									
GPR158	57512	broad.mit.edu	37	10	25464659	25464659	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr10:25464659G>C	uc001isj.2	+	1	370	c.310G>C	c.(310-312)GAG>CAG	p.E104Q	LOC100128811_uc010qde.1_Missense_Mutation_p.S98W	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	104	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						CGGCCGCTACGAGTTGGCGGG	0.677		NaN											0	0	0	0.004482	0	5	81									
APBB1IP	54518	broad.mit.edu	37	10	26800720	26800720	+	Silent	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr10:26800720G>A	uc001iss.2	+	7	897	c.576G>A	c.(574-576)CTG>CTA	p.L192L	APBB1IP_uc009xks.1_Silent_p.L192L	NM_019043	NP_061916	Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding,	192	Ras-associating.				blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium				lung(4)|skin(2)|central_nervous_system(1)	7						CAAAGTCACTGATGGTGGATG	0.473		NaN											0	0	0	0.00308	0	6	127									
YME1L1	10730	broad.mit.edu	37	10	27423784	27423784	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr10:27423784G>A	uc001iti.2	-	7	1020	c.838C>T	c.(838-840)CAA>TAA	p.Q280*	YME1L1_uc001itj.2_Nonsense_Mutation_p.Q223*|YME1L1_uc010qdl.1_Nonsense_Mutation_p.Q190*|YME1L1_uc009xkv.2_RNA	NM_139312	NP_647473	Q96TA2	YMEL1_HUMAN	YME1-like 1 isoform 1	280					protein catabolic process|proteolysis	membrane|mitochondrion	ATP binding|metal ion binding|metalloendopeptidase activity|nucleoside-triphosphatase activity			ovary(1)	1						GTGAGTGCTTGAGCTTTCAGA	0.368		NaN											0	0	0	0.00308	0	6	92									
CUL2	8453	broad.mit.edu	37	10	35317752	35317752	+	Nonsense_Mutation	SNP	T	T	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr10:35317752T>A	uc001ixv.2	-	16	1813	c.1603A>T	c.(1603-1605)AAA>TAA	p.K535*	CUL2_uc009xma.2_Nonsense_Mutation_p.K404*|CUL2_uc010qer.1_Nonsense_Mutation_p.K554*|CUL2_uc001ixw.2_Nonsense_Mutation_p.K535*|CUL2_uc010qes.1_Nonsense_Mutation_p.K472*	NM_003591	NP_003582	Q13617	CUL2_HUMAN	cullin 2	535					cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex	ubiquitin protein ligase binding			ovary(3)	3						TGTACACTTTTTTCTAATTCC	0.323		NaN											0	0	0	0.004672	0	3	39									
BMS1	9790	broad.mit.edu	37	10	43293936	43293936	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr10:43293936G>C	uc001jaj.2	+	12	2468	c.2110G>C	c.(2110-2112)GAA>CAA	p.E704Q		NM_014753	NP_055568	Q14692	BMS1_HUMAN	BMS1-like, ribosome assembly protein	704					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			ovary(2)|upper_aerodigestive_tract(1)	3						TAATGAAGAAGAAGATGATGA	0.438		NaN											0	0	0	0.004482	0	7	75									
VDAC2	7417	broad.mit.edu	37	10	76982062	76982062	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr10:76982062C>T	uc001jwz.2	+	8	796	c.637C>T	c.(637-639)CTT>TTT	p.L213F	VDAC2_uc010qld.1_Missense_Mutation_p.L174F|VDAC2_uc001jxa.2_Missense_Mutation_p.L228F|VDAC2_uc010qle.1_Missense_Mutation_p.L174F	NM_003375	NP_003366	P45880	VDAC2_HUMAN	voltage-dependent anion channel 2	213	Beta stranded; (By similarity).					mitochondrial nucleoid|mitochondrial outer membrane|pore complex	nucleotide binding|porin activity|protein binding|voltage-gated anion channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.0642)|all_epithelial(25;0.00604)|Prostate(51;0.0112)|Ovarian(15;0.183)				Dihydroxyaluminium(DB01375)	TTGTGAAGATCTTGACACTTC	0.358		NaN											0	0	0	0.000978	0	9	97									
ATRNL1	26033	broad.mit.edu	37	10	117040926	117040926	+	Missense_Mutation	SNP	G	G	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr10:117040926G>T	uc001lcg.2	+	14	2548	c.2162G>T	c.(2161-2163)AGC>ATC	p.S721I		NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	721	PSI 3.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		AAACTTACCAGCTGTAAAAGC	0.353		NaN											1	0	2.31682e-05	0.003163	2.44935e-05	11	66									
EBF3	253738	broad.mit.edu	37	10	131671831	131671831	+	Silent	SNP	G	G	A	rs147554322		TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr10:131671831G>A	uc001lki.1	-	8	725	c.666C>T	c.(664-666)GAC>GAT	p.D222D		NM_001005463	NP_001005463	Q9H4W6	COE3_HUMAN	early B-cell factor 3	222					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|pancreas(1)	2		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		GCACGTGGCCGTCCACGTTGA	0.522		NaN											0	0	0	0.004672	0	3	48									
MUC5B	727897	broad.mit.edu	37	11	1154305	1154305	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:1154305G>A	uc009ycr.1	+	3	277	c.151G>A	c.(151-153)GGG>AGG	p.G51R		NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GGGGCCCAGCGGTGAGTCTGA	0.667		NaN											0	0	0	0.00308	0	6	26									
MUC5B	727897	broad.mit.edu	37	11	1263825	1263825	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:1263825G>C	uc009ycr.1	+	47	7920	c.7794G>C	c.(7792-7794)TGG>TGC	p.W2598C	MUC5B_uc001ltb.2_Missense_Mutation_p.W1908C	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	1905	7 X Cys-rich subdomain repeats.|11 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GGACGACCTGGATCCTCACAA	0.637		NaN											0	0	0	0.006122	0	14	209									
KCNQ1	3784	broad.mit.edu	37	11	2610039	2610039	+	Missense_Mutation	SNP	G	G	C	rs148266527		TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:2610039G>C	uc001lwn.2	+	10	1456	c.1348G>C	c.(1348-1350)GAG>CAG	p.E450Q	KCNQ1_uc009ydp.1_Missense_Mutation_p.E234Q|KCNQ1_uc001lwo.2_Missense_Mutation_p.E323Q	NM_000218	NP_000209	P51787	KCNQ1_HUMAN	potassium voltage-gated channel, KQT-like	450	Cytoplasmic (Potential).				blood circulation|membrane depolarization|muscle contraction|sensory perception of sound		delayed rectifier potassium channel activity|protein binding			ovary(1)	1		all_epithelial(84;3.26e-05)|Breast(177;0.001)|Medulloblastoma(188;0.00111)|Ovarian(85;0.00158)|all_neural(188;0.00725)|all_lung(207;0.11)|Lung NSC(207;0.159)		BRCA - Breast invasive adenocarcinoma(625;0.00251)|Lung(200;0.131)	Bepridil(DB01244)|Indapamide(DB00808)	CCCCCCAGAAGAGCGGCGGCT	0.562		NaN											0	0	0	0.000602	0	4	15									
OR56A4	120793	broad.mit.edu	37	11	6023979	6023979	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:6023979G>C	uc010qzv.1	-	1	400	c.400C>G	c.(400-402)CCC>GCC	p.P134A		NM_001005179	NP_001005179	Q8NGH8	O56A4_HUMAN	olfactory receptor, family 56, subfamily A,	82	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGGACCTTGGGGATGACGGTG	0.567		NaN											0	0	0	0.001855	0	11	94									
OR10A6	390093	broad.mit.edu	37	11	7950137	7950137	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:7950137C>G	uc010rbh.1	-	1	73	c.73G>C	c.(73-75)GGG>CGG	p.G25R		NM_001004461	NP_001004461	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A,	25	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AAGAGCTGCCCCTGGAGCTCA	0.438		NaN											0	0	0	0.009096	0	4	89									
SBF2	81846	broad.mit.edu	37	11	9851008	9851008	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:9851008C>T	uc001mib.2	-	28	3826	c.3688G>A	c.(3688-3690)GAA>AAA	p.E1230K		NM_030962	NP_112224	Q86WG5	MTMRD_HUMAN	SET binding factor 2	1230	Myotubularin phosphatase.				myelination	cytoplasm|membrane	phosphatase activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		TTCTCTTGTTCTATGCTACTG	0.368		NaN											0	0	0	0.001984	0	5	93									
NAV2	89797	broad.mit.edu	37	11	20113769	20113769	+	Silent	SNP	G	G	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:20113769G>T	uc001mpr.3	+	28	6040	c.5679G>T	c.(5677-5679)CTG>CTT	p.L1893L	NAV2_uc001mpp.2_Silent_p.L1826L|NAV2_uc009yhx.2_Silent_p.L954L|NAV2_uc009yhz.2_Silent_p.L535L|NAV2_uc001mpu.2_Silent_p.L328L	NM_182964	NP_892009	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 1	1949	Potential.					nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						TAGAGAAGCTGAAAGCTGAGA	0.498		NaN											1	0	0.00198382	0.001984	0.0020327	6	91									
NAV2	89797	broad.mit.edu	37	11	20113776	20113776	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:20113776G>A	uc001mpr.3	+	28	6047	c.5686G>A	c.(5686-5688)GAG>AAG	p.E1896K	NAV2_uc001mpp.2_Missense_Mutation_p.E1829K|NAV2_uc009yhx.2_Missense_Mutation_p.E957K|NAV2_uc009yhz.2_Missense_Mutation_p.E538K|NAV2_uc001mpu.2_Missense_Mutation_p.E331K	NM_182964	NP_892009	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 1	1952	Potential.					nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						GCTGAAAGCTGAGAATGATCG	0.507		NaN											0	0	0	0.00308	0	6	97									
DCDC1	341019	broad.mit.edu	37	11	31329201	31329201	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:31329201G>A	uc001msv.2	-	4	621	c.419C>T	c.(418-420)CCA>CTA	p.P140L	DCDC1_uc001msu.1_5'UTR	NM_181807	NP_861523	P59894	DCDC1_HUMAN	doublecortin domain containing 1	140					intracellular signal transduction					skin(1)	1	Lung SC(675;0.225)					TTGACCCACTGGAGCACTGAC	0.358		NaN											0	0	0	0.003163	0	12	95									
COMMD9	29099	broad.mit.edu	37	11	36297736	36297736	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:36297736G>A	uc001mwn.3	-	5	444	c.407C>T	c.(406-408)TCA>TTA	p.S136L	COMMD9_uc009ykj.2_Missense_Mutation_p.S94L|COMMD9_uc009yki.1_5'Flank	NM_014186	NP_054905	Q9P000	COMD9_HUMAN	COMM domain containing 9 isoform 1	136	COMM.									ovary(1)	1	all_lung(20;0.211)	all_hematologic(20;0.107)				GATGCTGTCTGAGGAGGTTTT	0.552		NaN											0	0	0	0.001168	0	5	92									
TSPAN18	90139	broad.mit.edu	37	11	44948255	44948255	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:44948255G>A	uc001mye.3	+	7	807	c.646G>A	c.(646-648)GAG>AAG	p.E216K	TP53I11_uc001myf.1_Intron|TSPAN18_uc001myg.2_Missense_Mutation_p.E216K	NM_130783	NP_570139	Q96SJ8	TSN18_HUMAN	tetraspanin 18 isoform 2	216	Extracellular (Potential).					integral to membrane					0						CAACACCTTCGAGACCTACGT	0.592		NaN									OREG0020922	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00333	0	19	252									
OR5T3	390154	broad.mit.edu	37	11	56020432	56020432	+	Silent	SNP	T	T	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:56020432T>C	uc010rjd.1	+	1	757	c.757T>C	c.(757-759)TTG>CTG	p.L253L		NM_001004747	NP_001004747	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T,	253	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(21;0.00448)					TTTCATTCTGTTGTCCATTCT	0.413		NaN											0	0	0	0.004007	0	14	184									
TNKS1BP1	85456	broad.mit.edu	37	11	57076793	57076793	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:57076793C>G	uc001njr.2	-	5	3704	c.3392G>C	c.(3391-3393)AGA>ACA	p.R1131T	TNKS1BP1_uc001njs.2_Missense_Mutation_p.R1131T|TNKS1BP1_uc009ymd.1_Missense_Mutation_p.R582T	NM_033396	NP_203754	Q9C0C2	TB182_HUMAN	tankyrase 1-binding protein 1	1131	Gly-rich.|Acidic.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			skin(1)	1		all_epithelial(135;0.21)				ACCACTCACTCTGTCGTTGCC	0.577		NaN											0	0	0	0.00499	0	13	144									
SLC43A1	8501	broad.mit.edu	37	11	57259332	57259332	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:57259332G>A	uc001nkk.2	-	9	993	c.875C>T	c.(874-876)TCT>TTT	p.S292F	SLC43A1_uc001nkl.2_Missense_Mutation_p.S292F	NM_003627	NP_003618	O75387	LAT3_HUMAN	solute carrier family 43, member 1	292					cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	neutral amino acid transmembrane transporter activity				0						TAAGGGGACAGACCCTGGGGA	0.607		NaN									OREG0020651	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.009096	0	4	37									
OR6Q1	219952	broad.mit.edu	37	11	57799186	57799186	+	Silent	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:57799186C>T	uc010rjz.1	+	1	762	c.762C>T	c.(760-762)CTC>CTT	p.L254L	OR9Q1_uc001nmj.2_Intron	NM_001005186	NP_001005186	Q8NGQ2	OR6Q1_HUMAN	olfactory receptor, family 6, subfamily Q,	254	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)	1		Breast(21;0.0707)|all_epithelial(135;0.142)				TGGTGAGCCTCTTCTATGGCA	0.522		NaN											0	0	0	0.00333	0	18	128									
FAM111B	374393	broad.mit.edu	37	11	58893123	58893123	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:58893123C>G	uc001nnl.2	+	4	1796	c.1553C>G	c.(1552-1554)ACT>AGT	p.T518S	FAM111B_uc001nnm.2_Missense_Mutation_p.T488S|FAM111B_uc010rko.1_Missense_Mutation_p.T488S	NM_198947	NP_945185	Q6SJ93	F111B_HUMAN	hypothetical protein LOC374393 isoform a	518							catalytic activity			ovary(2)	2						GTAACCTTCACTTATACAGAG	0.373		NaN											0	0	0	0.004007	0	13	147									
CDC42BPG	55561	broad.mit.edu	37	11	64595223	64595223	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:64595223C>T	uc001obs.3	-	31	4000	c.4000G>A	c.(4000-4002)GAG>AAG	p.E1334K		NM_017525	NP_059995	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	1334	CNH.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(3)|central_nervous_system(1)	4						ATGGAGTTCTCGCTGAACACT	0.637		NaN											0	0	0	0.004482	0	7	84									
LTBP3	4054	broad.mit.edu	37	11	65318916	65318916	+	Silent	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:65318916C>T	uc001oej.2	-	10	1847	c.1578G>A	c.(1576-1578)CAG>CAA	p.Q526Q	LTBP3_uc001oeh.2_5'Flank|LTBP3_uc010roi.1_Silent_p.Q409Q|LTBP3_uc001oei.2_Silent_p.Q526Q|LTBP3_uc010roj.1_Silent_p.Q227Q|LTBP3_uc010rok.1_Silent_p.Q437Q	NM_001130144	NP_001123616	Q9NS15	LTBP3_HUMAN	latent transforming growth factor beta binding	526						extracellular region	calcium ion binding|growth factor binding			central_nervous_system(2)|lung(1)	3						TTGGGTGGCTCTGCTGCACTG	0.652		NaN											0	0	0	0.001168	0	5	55									
TMEM151A	256472	broad.mit.edu	37	11	66063113	66063113	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:66063113G>A	uc001ohl.2	+	2	1508	c.1396G>A	c.(1396-1398)GGT>AGT	p.G466S		NM_153266	NP_694998	Q8N4L1	T151A_HUMAN	transmembrane protein 151A	466						integral to membrane				central_nervous_system(1)	1						GGATGGGCAGGGTGCTCTCTG	0.652		NaN											0	0	0	0.001984	0	5	27									
ZDHHC24	254359	broad.mit.edu	37	11	66313210	66313210	+	Silent	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:66313210G>A	uc001oin.1	-	1	462	c.265C>T	c.(265-267)CTG>TTG	p.L89L	ACTN3_uc010rpi.1_5'Flank|ACTN3_uc001oio.1_5'Flank|ZDHHC24_uc001oim.1_RNA|ZDHHC24_uc009yrg.1_Silent_p.L89L	NM_207340	NP_997223	Q6UX98	ZDH24_HUMAN	zinc finger, DHHC-type containing 24	89						integral to membrane	acyltransferase activity|zinc ion binding				0						CCCTGGCCCAGACCGCGGCCG	0.701		NaN											0	0	0	0.004672	0	3	14									
RNF169	254225	broad.mit.edu	37	11	74545750	74545750	+	Missense_Mutation	SNP	A	A	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:74545750A>G	uc001ovl.3	+	5	885	c.872A>G	c.(871-873)CAG>CGG	p.Q291R	XRRA1_uc001ovm.2_Intron	NM_001098638	NP_001092108	Q8NCN4	RN169_HUMAN	ring finger protein 169	291							zinc ion binding			ovary(1)	1						GAAAGGAGTCAGAGCTGTAGT	0.443		NaN											0	0	0	0.009096	0	4	58									
SLCO2B1	11309	broad.mit.edu	37	11	74873787	74873787	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:74873787C>T	uc001owb.2	+	2	491	c.104C>T	c.(103-105)CCA>CTA	p.P35L	SLCO2B1_uc010rrp.1_RNA|SLCO2B1_uc010rrq.1_Intron|SLCO2B1_uc010rrr.1_Intron|SLCO2B1_uc010rrs.1_Intron|SLCO2B1_uc001owc.2_Intron|SLCO2B1_uc001owd.2_Missense_Mutation_p.P13L	NM_007256	NP_009187	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family,	35	Cytoplasmic (Potential).				sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity			ovary(1)|breast(1)	2					Ergoloid mesylate(DB01049)	AAAGCCAGCCCAGACCCTCAG	0.547		NaN											0	0	0	0.001368	0	12	147									
NCAM1	4684	broad.mit.edu	37	11	113130955	113130955	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:113130955G>A	uc001pns.2	+	2	213	c.181G>A	c.(181-183)GAG>AAG	p.E61K				P13591	NCAM1_HUMAN	SubName: Full=cDNA FLJ52974, highly similar to Neural cell adhesion molecule 1, 140 kDa isoform;	681	Extracellular (Potential).|Fibronectin type-III 2.				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				ovary(1)	1		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		TGCTGAGTATGAGGTCTACGT	0.567		NaN											0	0	0	0.006214	0	8	88									
USP2	9099	broad.mit.edu	37	11	119244114	119244114	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:119244114C>T	uc001pwm.3	-	2	372	c.77G>A	c.(76-78)GGC>GAC	p.G26D	USP2_uc001pwn.3_Intron	NM_004205	NP_004196	O75604	UBP2_HUMAN	ubiquitin specific peptidase 2 isoform a	26	Necessary for interaction with MDM4.				cell cycle|muscle organ development|negative regulation of transcription from RNA polymerase II promoter|positive regulation of mitotic cell cycle|protein deubiquitination|protein stabilization|ubiquitin-dependent protein catabolic process	nucleus|perinuclear region of cytoplasm	cyclin binding|cysteine-type endopeptidase activity|metal ion binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity			ovary(2)|urinary_tract(1)|skin(1)	4		all_hematologic(192;4.65e-05)|Breast(348;0.0101)|all_neural(223;0.0218)|Medulloblastoma(222;0.0425)|Renal(330;0.157)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.000513)|Colorectal(284;0.0116)|Lung(307;0.0853)|LUSC - Lung squamous cell carcinoma(976;0.0889)		GGCACCATAGCCCGACTTGGC	0.597		NaN											0	0	0	0.001168	0	5	35									
ARHGEF12	23365	broad.mit.edu	37	11	120312861	120312861	+	Missense_Mutation	SNP	A	A	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:120312861A>G	uc001pxl.1	+	15	1259	c.1252A>G	c.(1252-1254)ACT>GCT	p.T418A	ARHGEF12_uc009zat.2_Missense_Mutation_p.T399A|ARHGEF12_uc010rzn.1_Missense_Mutation_p.T315A|ARHGEF12_uc009zau.1_Missense_Mutation_p.T315A	NM_015313	NP_056128	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	418	RGSL.				apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(2)|breast(2)|skin(2)|ovary(1)	7		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		TTCCAAAGAAACTCGTCGCAT	0.358		NaN	T	MLL	AML								0	0	0	0.009096	0	4	50									
SORL1	6653	broad.mit.edu	37	11	121414362	121414362	+	Silent	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:121414362C>T	uc001pxx.2	+	13	1871	c.1791C>T	c.(1789-1791)TTC>TTT	p.F597F		NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	597	Extracellular (Potential).				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		GCACTGTCTTCACCATCTTTG	0.512		NaN											0	0	0	0.006214	0	7	185									
SORL1	6653	broad.mit.edu	37	11	121414368	121414368	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:121414368C>G	uc001pxx.2	+	13	1877	c.1797C>G	c.(1795-1797)ATC>ATG	p.I599M		NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	599	Extracellular (Potential).				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		TCTTCACCATCTTTGGCTCGA	0.512		NaN											0	0	0	0.00308	0	7	181									
ADIPOR2	79602	broad.mit.edu	37	12	1895205	1895205	+	Silent	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:1895205C>T	uc001qjm.2	+	8	1325	c.1128C>T	c.(1126-1128)ATC>ATT	p.I376I	ADIPOR2_uc001qjn.2_Silent_p.I376I	NM_024551	NP_078827	Q86V24	ADR2_HUMAN	adiponectin receptor 2	376	Extracellular (Potential).				fatty acid oxidation|hormone-mediated signaling pathway	integral to membrane	hormone binding|receptor activity				0	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000382)			GTTTCATGATCGGCGGGGGCT	0.532		NaN											0	0	0	0.001984	0	7	117									
PRMT8	56341	broad.mit.edu	37	12	3692332	3692332	+	Missense_Mutation	SNP	A	A	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:3692332A>G	uc001qmf.2	+	8	1304	c.937A>G	c.(937-939)ATT>GTT	p.I313V	PRMT8_uc009zed.2_Missense_Mutation_p.I304V|PRMT8_uc009zee.1_RNA|PRMT8_uc001qmg.2_Missense_Mutation_p.I127V	NM_019854	NP_062828	Q9NR22	ANM8_HUMAN	HMT1 hnRNP methyltransferase-like 4	313					regulation of protein binding	cytoplasm|plasma membrane	histone-arginine N-methyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity			ovary(3)|central_nervous_system(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(31;0.0109)|COAD - Colon adenocarcinoma(12;0.0264)			CTATTTTAATATTGAATTTAC	0.478		NaN											0	0	0	0.000602	0	4	20									
CLSTN3	9746	broad.mit.edu	37	12	7290563	7290563	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:7290563C>G	uc001qsr.2	+	8	1501	c.1223C>G	c.(1222-1224)TCT>TGT	p.S408C	CLSTN3_uc001qss.2_Missense_Mutation_p.S420C	NM_014718	NP_055533	Q9BQT9	CSTN3_HUMAN	calsyntenin 3 precursor	408	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			large_intestine(1)	1						GACGGCTTCTCTCACTACTCG	0.577		NaN											0	0	0	0.006122	0	15	105									
SLCO1B3	28234	broad.mit.edu	37	12	21036424	21036424	+	Missense_Mutation	SNP	T	T	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:21036424T>A	uc001rek.2	+	12	1696	c.1570T>A	c.(1570-1572)TGC>AGC	p.C524S	SLCO1B3_uc001rel.2_Missense_Mutation_p.C524S|SLCO1B3_uc010sil.1_Missense_Mutation_p.C524S|LST-3TM12_uc010sim.1_Intron|SLCO1B3_uc001reo.2_Missense_Mutation_p.C349S	NM_019844	NP_062818	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family,	524	Extracellular (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					CTTGGGTGAATGCCCAAGAGA	0.338		NaN											0	0	0	0.001984	0	5	79									
DDX11	1663	broad.mit.edu	37	12	31242861	31242861	+	Silent	SNP	A	A	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:31242861A>C	uc001rjt.1	+	9	1173	c.922A>C	c.(922-924)AGG>CGG	p.R308R	DDX11_uc010sjw.1_3'UTR|DDX11_uc010sjx.1_RNA|DDX11_uc001rjr.1_Silent_p.R308R|DDX11_uc001rjs.1_Silent_p.R308R|DDX11_uc001rju.1_5'UTR|DDX11_uc001rjv.1_Silent_p.R308R|DDX11_uc001rjw.1_Silent_p.R282R|DDX11_uc001rjx.1_5'UTR|DDX11_uc009zjn.1_RNA	NM_152438	NP_689651	Q96FC9	DDX11_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11	308	Helicase ATP-binding.				G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|S phase of mitotic cell cycle|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|RNA binding			breast(3)	3	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					AAAGAGGAGGAGGCAGGAGAA	0.587		NaN								Multiple Myeloma(12;0.14)			0	0	0	0.001984	0	3	14									
LRRK2	120892	broad.mit.edu	37	12	40631899	40631899	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:40631899G>A	uc001rmg.3	+	5	686	c.565G>A	c.(565-567)GAG>AAG	p.E189K		NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	189					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TGTGCTGTTTGAGAGAGGTAT	0.318		NaN											0	0	0	0.004482	0	8	59									
ARID2	196528	broad.mit.edu	37	12	46230554	46230554	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:46230554C>T	uc001ros.1	+	8	803	c.803C>T	c.(802-804)TCT>TTT	p.S268F	ARID2_uc001ror.2_Missense_Mutation_p.S268F|ARID2_uc009zkg.1_5'UTR|ARID2_uc009zkh.1_5'Flank|ARID2_uc001rot.1_5'UTR	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	268					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		ATTTGGGAGTCTTTATTTCAT	0.348		NaN											0	0	0	0.00308	0	7	74									
ARID2	196528	broad.mit.edu	37	12	46298835	46298835	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:46298835G>C	uc001ros.1	+	21	5482	c.5482G>C	c.(5482-5484)GAA>CAA	p.E1828Q	ARID2_uc009zkg.1_Missense_Mutation_p.E1284Q|ARID2_uc009zkh.1_Missense_Mutation_p.E1455Q|ARID2_uc001rou.1_3'UTR	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	1828					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		TAAGGAACAAGAAAAAGACTC	0.388		NaN											0	0	0	0.009096	0	3	34									
C12orf41	54934	broad.mit.edu	37	12	49054188	49054188	+	Silent	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:49054188C>T	uc001rrx.2	-	8	1263	c.1188G>A	c.(1186-1188)GAG>GAA	p.E396E	C12orf41_uc001rrw.2_Intron|C12orf41_uc001rrz.2_Silent_p.E579E|C12orf41_uc001rry.2_Intron|C12orf41_uc001rru.2_Silent_p.E27E|C12orf41_uc001rrv.2_Intron	NM_017822	NP_060292	Q9H9L4	CL041_HUMAN	hypothetical protein LOC54934	396										ovary(2)	2						TGGGCTGAAGCTCAGCAGCAC	0.493		NaN											0	0	0	0.001168	0	5	35									
MLL2	8085	broad.mit.edu	37	12	49445757	49445757	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:49445757G>C	uc001rta.3	-	10	1709	c.1709C>G	c.(1708-1710)TCT>TGT	p.S570C		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	570	15 X 5 AA repeats of S/P-P-P-E/P-E/A.|Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						AGACAGGCGAGATGCTTCAGG	0.592		NaN	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.001368	0	12	151									
LARP4	113251	broad.mit.edu	37	12	50829320	50829320	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:50829320C>T	uc001rwp.1	+	5	592	c.448C>T	c.(448-450)CAG>TAG	p.Q150*	LARP4_uc001rwo.1_Nonsense_Mutation_p.Q156*|LARP4_uc001rwq.1_Nonsense_Mutation_p.Q150*|LARP4_uc001rwr.1_Nonsense_Mutation_p.Q150*|LARP4_uc001rws.1_Nonsense_Mutation_p.Q149*|LARP4_uc009zlr.1_5'Flank|LARP4_uc001rwm.2_Nonsense_Mutation_p.Q150*|LARP4_uc001rwn.2_Nonsense_Mutation_p.Q80*	NM_052879	NP_443111	Q71RC2	LARP4_HUMAN	c-Mpl binding protein isoform a	150	HTH La-type RNA-binding.						nucleotide binding|RNA binding			ovary(1)	1						GGATAGTGATCAGTTCATCCC	0.299		NaN											0	0	0	0.00308	0	5	47									
TFCP2	7024	broad.mit.edu	37	12	51500367	51500367	+	Silent	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:51500367G>A	uc001rxw.2	-	8	1317	c.858C>T	c.(856-858)GTC>GTT	p.V286V	TFCP2_uc001rxv.1_Silent_p.V286V|TFCP2_uc009zlx.1_Silent_p.V235V|TFCP2_uc001rxx.2_Silent_p.V286V|TFCP2_uc009zly.1_Silent_p.V188V	NM_005653	NP_005644	Q12800	TFCP2_HUMAN	transcription factor CP2	286	DNA-binding.				regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GGGAGTTATTGACATACGTGA	0.398		NaN											0	0	0	0.001984	0	5	55									
KRT72	140807	broad.mit.edu	37	12	52984645	52984645	+	Nonsense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:52984645G>C	uc001sar.2	-	6	1150	c.1064C>G	c.(1063-1065)TCA>TGA	p.S355*	KRT72_uc001saq.2_Nonsense_Mutation_p.S355*|KRT72_uc010sns.1_Intron|KRT72_uc010snt.1_Nonsense_Mutation_p.S167*	NM_001146225	NP_001139697	Q14CN4	K2C72_HUMAN	keratin 72 isoform 1	355	Coil 2.|Rod.					keratin filament	structural molecule activity			ovary(5)|pancreas(1)	6				BRCA - Breast invasive adenocarcinoma(357;0.195)		CCCTATCTCTGAGCGGATCCT	0.488		NaN											0	0	0	0.00245	0	12	98									
RARG	5916	broad.mit.edu	37	12	53605514	53605514	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:53605514G>C	uc001sce.2	-	10	1796	c.1311C>G	c.(1309-1311)AGC>AGG	p.S437R	RARG_uc001scd.2_Missense_Mutation_p.S426R|RARG_uc010sob.1_Missense_Mutation_p.S415R|RARG_uc001scf.2_Missense_Mutation_p.S437R|RARG_uc001scg.2_Missense_Mutation_p.S365R|RARG_uc010soc.1_Missense_Mutation_p.S316R	NM_000966	NP_000957	P13631	RARG_HUMAN	retinoic acid receptor, gamma isoform 1	437					canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|ovary(1)|lung(1)	4					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	CCTCATCCTCGCTAGAGGCAT	0.637		NaN											0	0	0	0.004672	0	3	23									
ATF7	11016	broad.mit.edu	37	12	53994749	53994749	+	Silent	SNP	C	C	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:53994749C>A	uc001sdy.2	-	1	57	c.36G>T	c.(34-36)CCG>CCT	p.P12P	ATF7_uc010sok.1_RNA|ATF7_uc001sdz.2_Silent_p.P12P|ATF7_uc010sol.1_Silent_p.P12P|ATF7_uc001sea.3_Silent_p.P12P|ATF7_uc001seb.3_Silent_p.P12P	NM_001130059	NP_001123531	P17544	ATF7_HUMAN	activating transcription factor 7 isoform 1	12	C2H2-type.|Transactivation domain.				interspecies interaction between organisms	cytoplasm|nuclear periphery|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)	2						GTCCACAGCCCGGGGCATTGC	0.433		NaN											1	0	0.00198382	0.001984	0.0020327	5	38									
ZBTB39	9880	broad.mit.edu	37	12	57398642	57398642	+	Silent	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:57398642G>C	uc001sml.1	-	2	146	c.60C>G	c.(58-60)CTC>CTG	p.L20L	RDH16_uc010sqx.1_5'Flank	NM_014830	NP_055645	O15060	ZBT39_HUMAN	zinc finger and BTB domain containing 39	20					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1						GGCACTTGTTGAGTTCCTTCA	0.557		NaN											0	0	0	0.008291	0	9	206									
NUP107	57122	broad.mit.edu	37	12	69121157	69121157	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:69121157G>C	uc001suf.2	+	20	1837	c.1722G>C	c.(1720-1722)AAG>AAC	p.K574N	NUP107_uc001sug.2_Missense_Mutation_p.K421N|NUP107_uc010stj.1_Missense_Mutation_p.K545N	NM_020401	NP_065134	P57740	NU107_HUMAN	nucleoporin 107kDa	574					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			skin(1)	1	Breast(13;6.25e-06)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)			AAGTTTTAAAGACATACATAC	0.269		NaN											0	0	0	0.000602	0	4	83									
LGR5	8549	broad.mit.edu	37	12	71960693	71960693	+	Splice_Site	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:71960693G>A	uc001swl.2	+	11	1118	c.1070_splice	c.e11+1	p.L357_splice	LGR5_uc001swm.2_Splice_Site_p.L333_splice|LGR5_uc001swn.1_RNA	NM_003667	NP_003658	O75473	LGR5_HUMAN	leucine-rich repeat-containing G protein-coupled							integral to plasma membrane	protein-hormone receptor activity			lung(4)|skin(3)|ovary(1)|pancreas(1)	9						TCCAAGTGCTGTGCGTATCAG	0.393		NaN											0	0	0	0.001984	0	6	89									
EEA1	8411	broad.mit.edu	37	12	93226360	93226360	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:93226360C>G	uc001tck.2	-	11	1447	c.1182G>C	c.(1180-1182)GAG>GAC	p.E394D		NM_003566	NP_003557	Q15075	EEA1_HUMAN	early endosome antigen 1, 162kD	394	Potential.				early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			ovary(2)|skin(1)	3						GCTGCTTAAACTCCGCCTTTA	0.358		NaN											0	0	0	0.000978	0	9	201									
FGD6	55785	broad.mit.edu	37	12	95566467	95566467	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:95566467G>A	uc001tdp.3	-	3	2719	c.2495C>T	c.(2494-2496)TCT>TTT	p.S832F	FGD6_uc009zsx.2_5'UTR	NM_018351	NP_060821	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	832				S -> P (in Ref. 3; CAD98096).	actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|breast(1)	3						CTCCTCATCAGAGGGAAGGTC	0.433		NaN											0	0	0	0.000978	0	10	163									
NUAK1	9891	broad.mit.edu	37	12	106500216	106500216	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:106500216G>C	uc001tlj.1	-	2	1708	c.328C>G	c.(328-330)CTC>GTC	p.L110V		NM_014840	NP_055655	O60285	NUAK1_HUMAN	AMPK-related protein kinase 5	110	Protein kinase.						ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)|central_nervous_system(1)	2						GGATGGTTGAGAGATGACATG	0.373		NaN											0	0	0	0.009096	0	3	33									
IFT81	28981	broad.mit.edu	37	12	110641690	110641690	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:110641690G>C	uc001tqi.2	+	15	1709	c.1579G>C	c.(1579-1581)GAA>CAA	p.E527Q	IFT81_uc001tqh.2_Missense_Mutation_p.E527Q|IFT81_uc001tqj.2_RNA	NM_001143779	NP_001137251	Q8WYA0	IFT81_HUMAN	intraflagellar transport 81-like isoform 1	527	Potential.				cell differentiation|multicellular organismal development|spermatogenesis	intraflagellar transport particle B|microtubule-based flagellum				ovary(1)	1						ggagtgtgatgaaaagaaatc	0.194		NaN											0	0	0	0.004482	0	9	36									
XPO4	64328	broad.mit.edu	37	13	21442787	21442787	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr13:21442787G>C	uc001unq.3	-	2	159	c.123C>G	c.(121-123)TTC>TTG	p.F41L	XPO4_uc010tcr.1_Intron	NM_022459	NP_071904	Q9C0E2	XPO4_HUMAN	exportin 4	41					protein transport	cytoplasm|nucleus	protein binding			large_intestine(1)|ovary(1)|kidney(1)	3		all_cancers(29;5.05e-24)|all_epithelial(30;5.56e-20)|all_lung(29;2.38e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000521)|Epithelial(112;0.000892)|OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Lung(94;0.0189)|LUSC - Lung squamous cell carcinoma(192;0.0548)		TAAATGATAAGAATATGTGCT	0.338		NaN											0	0	0	0.004482	0	7	195									
PARP4	143	broad.mit.edu	37	13	25008866	25008866	+	Silent	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr13:25008866C>T	uc001upl.2	-	31	4519	c.4413G>A	c.(4411-4413)TTG>TTA	p.L1471L		NM_006437	NP_006428	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	1471					cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			ovary(3)|skin(1)	4		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		GGTTGGCAGTCAAAGAGGCTG	0.493		NaN											0	0	0	0.004482	0	8	18									
RXFP2	122042	broad.mit.edu	37	13	32313816	32313816	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr13:32313816C>T	uc001utt.2	+	1	138	c.67C>T	c.(67-69)CAT>TAT	p.H23Y	RXFP2_uc010aba.2_Missense_Mutation_p.H6Y	NM_130806	NP_570718	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	23	Extracellular (Potential).					integral to membrane|plasma membrane					0		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		CTTTCTACTTCATTTCATCGT	0.333		NaN											0	0	0	0.001168	0	5	88									
LCP1	3936	broad.mit.edu	37	13	46708313	46708313	+	Silent	SNP	C	C	T	rs111548644		TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr13:46708313C>T	uc001vaz.3	-	14	1701	c.1575G>A	c.(1573-1575)GTG>GTA	p.V525V	LCP1_uc010ack.2_Silent_p.V94V|LCP1_uc001vay.3_Silent_p.V122V|LCP1_uc001vba.3_Silent_p.V525V	NM_002298	NP_002289	P13796	PLSL_HUMAN	L-plastin	525	Actin-binding 2.|CH 4.				regulation of intracellular protein transport|T cell activation involved in immune response	cell junction|cytosol|ruffle membrane	calcium ion binding			lung(4)|ovary(3)	7		Lung NSC(96;1.27e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.39e-05)		ATGTTTCATTCACCCAGTTGA	0.393		NaN	T	BCL6	NHL 								0	0	0	0.001368	0	11	93									
DACH1	1602	broad.mit.edu	37	13	72053440	72053440	+	Silent	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr13:72053440C>T	uc010thn.1	-	9	2154	c.1731G>A	c.(1729-1731)TTG>TTA	p.L577L	DACH1_uc010tho.1_Silent_p.L429L|DACH1_uc010thp.1_Silent_p.L375L	NM_080759	NP_542937	Q9UI36	DACH1_HUMAN	dachshund homolog 1 isoform a	629	DACHbox-C.|Interaction with SIN3A (By similarity).				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			breast(1)	1		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		TGGCAACTTTCAACAGCCCCT	0.358		NaN											0	0	0	0.006214	0	8	132									
DZIP1	22873	broad.mit.edu	37	13	96274734	96274734	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr13:96274734G>A	uc001vmk.2	-	9	1825	c.973C>T	c.(973-975)CAA>TAA	p.Q325*	DZIP1_uc001vml.2_Nonsense_Mutation_p.Q325*	NM_198968	NP_945319	Q86YF9	DZIP1_HUMAN	DAZ interacting protein 1 isoform 2	325	Potential.				germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			TCTGACAGTTGCTATAAGATA	0.373		NaN											0	0	0	0.00499	0	12	125									
MBNL2	10150	broad.mit.edu	37	13	97999162	97999162	+	Silent	SNP	A	A	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr13:97999162A>G	uc010aft.2	+	5	1461	c.645A>G	c.(643-645)GTA>GTG	p.V215V	MBNL2_uc001vmz.2_Silent_p.V215V|MBNL2_uc001vna.2_Silent_p.V215V|MBNL2_uc001vnb.2_RNA|MBNL2_uc010tij.1_Intron|MBNL2_uc001vnc.2_5'Flank	NM_144778	NP_659002	Q5VZF2	MBNL2_HUMAN	muscleblind-like 2 isoform 1	215	C3H1-type 4.				mRNA processing|regulation of RNA splicing|RNA splicing	cytoplasm|nucleus	RNA binding|zinc ion binding				0	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.218)			ACAACACCGTAACCGTTTGTA	0.537		NaN											0	0	0	0.004007	0	14	102									
UBAC2	337867	broad.mit.edu	37	13	99992667	99992667	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr13:99992667G>C	uc001voa.3	+	7	1139	c.655G>C	c.(655-657)GAA>CAA	p.E219Q	UBAC2_uc010tiu.1_Missense_Mutation_p.E241Q|UBAC2_uc001vob.3_Missense_Mutation_p.E192Q|UBAC2_uc010tiv.1_Intron|UBAC2_uc001vod.2_Missense_Mutation_p.E106Q|UBAC2_uc001voc.2_Missense_Mutation_p.E184Q|UBAC2_uc010tiw.1_RNA|UBAC2_uc001voh.2_Missense_Mutation_p.E23Q	NM_001144072	NP_001137544	Q8NBM4	UBAC2_HUMAN	UBA domain containing 2 isoform 1	219	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TTGGACACTTGAACCCATCTT	0.527		NaN											0	0	0	0.000602	0	4	94									
ZIC2	7546	broad.mit.edu	37	13	100637333	100637333	+	Silent	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr13:100637333G>A	uc001von.2	+	2	1209	c.1209G>A	c.(1207-1209)ACG>ACA	p.T403T		NM_007129	NP_009060	O95409	ZIC2_HUMAN	zinc finger protein of the cerebellum 2	403	C2H2-type 5.		T -> K (in HPE5).		brain development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|visual perception	cytoplasm|nucleus	chromatin DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					AGTCCTACACGCACCCCAGCT	0.667		NaN											0	0	0	0.004007	0	13	124									
EFNB2	1948	broad.mit.edu	37	13	107147270	107147270	+	Missense_Mutation	SNP	C	C	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr13:107147270C>A	uc001vqi.2	-	4	597	c.572G>T	c.(571-573)GGA>GTA	p.G191V		NM_004093	NP_004084	P52799	EFNB2_HUMAN	ephrin B2 precursor	191	Extracellular (Potential).				cell differentiation|cell-cell signaling|interspecies interaction between organisms|nervous system development	integral to plasma membrane	ephrin receptor binding			ovary(1)	1	Lung NSC(43;0.015)|all_neural(89;0.0741)|Lung SC(71;0.14)|Medulloblastoma(90;0.169)					CGAACTTCTTCCATTTGTACC	0.393		NaN											1	0	5.01169e-05	0.00499	5.26492e-05	13	225									
CARS2	79587	broad.mit.edu	37	13	111296814	111296814	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr13:111296814C>T	uc001vrd.2	-	13	1374	c.1334G>A	c.(1333-1335)AGA>AAA	p.R445K	CARS2_uc010tjm.1_RNA	NM_024537	NP_078813	Q9HA77	SYCM_HUMAN	cysteinyl-tRNA synthetase 2, mitochondrial	445					cysteinyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|cysteine-tRNA ligase activity|metal ion binding				0	all_lung(23;3.61e-05)|Lung NSC(43;0.00144)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		BRCA - Breast invasive adenocarcinoma(86;0.163)		L-Cysteine(DB00151)	AGCAGGACTTCTCGGCCCTTC	0.423		NaN											0	0	0	0.001984	0	5	65									
TOX4	9878	broad.mit.edu	37	14	21960463	21960463	+	Silent	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr14:21960463G>A	uc001waz.2	+	6	922	c.819G>A	c.(817-819)AAG>AAA	p.K273K	TOX4_uc001way.2_Silent_p.K143K|TOX4_uc001wba.2_RNA|TOX4_uc010tlu.1_Silent_p.K250K|TOX4_uc010tlv.1_Silent_p.K143K	NM_014828	NP_055643	O94842	TOX4_HUMAN	epidermal Langerhans cell protein LCP1	273	HMG box.					chromatin|nucleus|PTW/PP1 phosphatase complex	DNA binding|protein binding			ovary(1)	1	all_cancers(95;0.000465)		Epithelial(56;6.61e-06)|all cancers(55;5.15e-05)	GBM - Glioblastoma multiforme(265;0.0149)		AGGTATATAAGAGGAAAACTG	0.358		NaN											0	0	0	0.006214	0	8	84									
MIPOL1	145282	broad.mit.edu	37	14	37969203	37969203	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr14:37969203G>C	uc001wuc.2	+	13	1625	c.1122G>C	c.(1120-1122)GAG>GAC	p.E374D	MIPOL1_uc010amr.2_RNA|MIPOL1_uc001wub.3_Missense_Mutation_p.E343D|MIPOL1_uc001wud.2_Missense_Mutation_p.E374D|MIPOL1_uc010ams.2_Missense_Mutation_p.E374D|MIPOL1_uc001wue.2_Missense_Mutation_p.E343D|MIPOL1_uc010amt.2_Missense_Mutation_p.E193D	NM_138731	NP_620059	Q8TD10	MIPO1_HUMAN	mirror-image polydactyly 1	374	Potential.									ovary(1)|central_nervous_system(1)	2	Breast(36;0.119)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;6.03e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.047)|all cancers(34;0.0953)|LUSC - Lung squamous cell carcinoma(13;0.0975)|BRCA - Breast invasive adenocarcinoma(188;0.196)	GBM - Glioblastoma multiforme(112;0.0358)		AAAACAGAGAGAACATTGTTT	0.348		NaN											0	0	0	0.001168	0	5	101									
PSMC6	5706	broad.mit.edu	37	14	53187697	53187697	+	Missense_Mutation	SNP	T	T	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr14:53187697T>G	uc010tqx.1	+	11	938	c.938T>G	c.(937-939)ATA>AGA	p.I313R	PSMC6_uc001wzy.2_5'Flank	NM_002806	NP_002797	P62333	PRS10_HUMAN	proteasome 26S ATPase subunit 6	299					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding, bridging			lung(1)	1	Breast(41;0.176)					GATAGAAAAATACGTGAGTTA	0.368		NaN											0	0	0	0.001855	0	10	192									
WDHD1	11169	broad.mit.edu	37	14	55429799	55429799	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr14:55429799G>C	uc001xbm.1	-	19	2480	c.2402C>G	c.(2401-2403)TCT>TGT	p.S801C	WDHD1_uc010aom.1_Missense_Mutation_p.S318C|WDHD1_uc001xbn.1_Missense_Mutation_p.S678C	NM_007086	NP_009017	O75717	WDHD1_HUMAN	WD repeat and HMG-box DNA binding protein 1	801						cytoplasm|nucleoplasm	DNA binding			skin(1)	1						CCGAGAGCGAGAAGCATATTT	0.383		NaN											0	0	0	0.001984	0	6	73									
KTN1	3895	broad.mit.edu	37	14	56122763	56122763	+	Silent	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr14:56122763G>A	uc001xcb.2	+	30	3107	c.2805G>A	c.(2803-2805)TTG>TTA	p.L935L	KTN1_uc001xce.2_Silent_p.L935L|KTN1_uc001xcc.2_Silent_p.L935L|KTN1_uc001xcd.2_Silent_p.L912L|KTN1_uc010trb.1_Silent_p.L935L|KTN1_uc001xcf.1_Silent_p.L912L|KTN1_uc010aoq.2_Silent_p.L230L	NM_182926	NP_891556	Q86UP2	KTN1_HUMAN	kinectin 1 isoform a	935	Lumenal (Potential).|Potential.				microtubule-based movement	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction				breast(3)|ovary(2)|lung(1)|central_nervous_system(1)	7						ATTCTAGGTTGAAAGAAAAGG	0.348		NaN	T	RET	papillary thryoid								0	0	0	0.000602	0	4	21									
RTN1	6252	broad.mit.edu	37	14	60213112	60213112	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr14:60213112G>C	uc001xen.1	-	2	538	c.329C>G	c.(328-330)TCT>TGT	p.S110C		NM_021136	NP_066959	Q16799	RTN1_HUMAN	reticulon 1 isoform A	110					neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		GCAGATGTCAGAAATGAGAGA	0.458		NaN											0	0	0	0.001984	0	6	57									
NEK9	91754	broad.mit.edu	37	14	75590902	75590902	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr14:75590902C>T	uc001xrl.2	-	2	398	c.244G>A	c.(244-246)GAA>AAA	p.E82K		NM_033116	NP_149107	Q8TD19	NEK9_HUMAN	NIMA-related kinase 9	82	Protein kinase.				cell division|mitosis	mitochondrion|nucleus	ATP binding|metal ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(2)|stomach(2)|ovary(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00718)		AAATCGACTTCCTTCCACACA	0.473		NaN											0	0	0	0.001984	0	6	60									
SERPINA11	256394	broad.mit.edu	37	14	94914814	94914814	+	Missense_Mutation	SNP	G	G	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr14:94914814G>T	uc001ydd.1	-	2	358	c.298C>A	c.(298-300)CTG>ATG	p.L100M		NM_001080451	NP_001073920	Q86U17	SPA11_HUMAN	serpin peptidase inhibitor, clade A (alpha-1	100					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			kidney(1)	1				COAD - Colon adenocarcinoma(157;0.211)		AGGCCCTCCAGGATCAGAGCT	0.617		NaN											1	0	0.000442599	0.006214	0.000457261	9	77									
PAPOLA	10914	broad.mit.edu	37	14	97003351	97003351	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr14:97003351G>A	uc001yfq.2	+	12	1279	c.1069G>A	c.(1069-1071)GAG>AAG	p.E357K	PAPOLA_uc001yfr.2_Missense_Mutation_p.E357K|PAPOLA_uc010twv.1_Missense_Mutation_p.E357K|PAPOLA_uc010avp.2_Missense_Mutation_p.E107K	NM_032632	NP_116021	P51003	PAPOA_HUMAN	poly(A) polymerase alpha	357					mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|RNA binding				0		all_cancers(154;0.0555)|all_epithelial(191;0.149)|Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.213)		GAGTAAGGCAGAGTGGTCCAA	0.313		NaN											0	0	0	0.001984	0	5	51									
C14orf177	283598	broad.mit.edu	37	14	99183486	99183486	+	Nonsense_Mutation	SNP	G	G	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr14:99183486G>T	uc001yfz.1	+	4	672	c.253G>T	c.(253-255)GAA>TAA	p.E85*		NM_182560	NP_872366	Q52M58	CN177_HUMAN	hypothetical protein LOC283598	85											0		Melanoma(154;0.128)				CCAGAGACATGAAGAAACTTC	0.453		NaN											1	0	1.06961e-07	0.00308	1.1503e-07	5	70									
C14orf73	91828	broad.mit.edu	37	14	103574805	103574805	+	Missense_Mutation	SNP	G	G	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr14:103574805G>T	uc001ymk.2	+	10	2003	c.1927G>T	c.(1927-1929)GAC>TAC	p.D643Y		NM_001077594	NP_001071062	Q17RC7	EX3L4_HUMAN	hypothetical protein LOC91828	643											0		Melanoma(154;0.155)	Epithelial(46;0.221)			CTACAAAGATGACATCCAGCG	0.602		NaN											1	0	7.41877e-09	0.001882	8.0303e-09	21	315									
HERC2	8924	broad.mit.edu	37	15	28408392	28408392	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr15:28408392G>A	uc001zbj.2	-	69	10700	c.10594C>T	c.(10594-10596)CAG>TAG	p.Q3532*		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	3532					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		TCCAAGGCCTGAGGCTCCGGA	0.502		NaN											0	0	0	0.00308	0	7	108									
C15orf23	90417	broad.mit.edu	37	15	40675233	40675233	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr15:40675233G>A	uc001zll.2	+	1	312	c.197G>A	c.(196-198)CGG>CAG	p.R66Q	C15orf23_uc010ucp.1_Missense_Mutation_p.R66Q|C15orf23_uc001zlo.2_Missense_Mutation_p.R66Q|C15orf23_uc001zlm.2_RNA|C15orf23_uc001zln.2_RNA	NM_033286	NP_150628	Q9Y448	T4AF1_HUMAN	TRAF4 associated factor 1 isoform a	66						nucleus	protein binding			ovary(1)|skin(1)	2		all_cancers(109;2.34e-14)|all_epithelial(112;9.21e-12)|Lung NSC(122;2.95e-09)|all_lung(180;6.03e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3.39e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0798)		GGGCAGGACCGGCGGGCTCCT	0.592		NaN											0	0	0	0.008291	0	10	136									
SNAP23	8773	broad.mit.edu	37	15	42821985	42821985	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr15:42821985C>G	uc001zpz.1	+	7	629	c.538C>G	c.(538-540)CAA>GAA	p.Q180E	SNAP23_uc001zqa.1_Missense_Mutation_p.Q127E	NM_003825	NP_003816	O00161	SNP23_HUMAN	synaptosomal-associated protein 23 isoform	180	t-SNARE coiled-coil homology 2.				cellular membrane fusion|post-Golgi vesicle-mediated transport|protein transport|vesicle targeting	azurophil granule|cell junction|Golgi apparatus|nucleus|plasma membrane enriched fraction|specific granule|synapse|synaptosome	protein binding				0		all_cancers(109;7.14e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;1.18e-08)|all_lung(180;4.2e-08)|Melanoma(134;0.0179)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;2.62e-06)		GATTGATGCTCAAAATCCACA	0.403		NaN											0	0	0	0.000602	0	5	72									
DMXL2	23312	broad.mit.edu	37	15	51772766	51772766	+	Silent	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr15:51772766G>C	uc002abf.2	-	24	6762	c.6537C>G	c.(6535-6537)CTC>CTG	p.L2179L	DMXL2_uc002abd.2_Silent_p.L249L|DMXL2_uc010ufy.1_Silent_p.L2179L|DMXL2_uc010bfa.2_Silent_p.L1543L	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	2179						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		GCAAAAATTTGAGTTCCATCC	0.393		NaN											0	0	0	0.00308	0	6	64									
TRIP4	9325	broad.mit.edu	37	15	64689913	64689913	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr15:64689913G>A	uc002anm.2	+	4	557	c.514G>A	c.(514-516)GAT>AAT	p.D172N		NM_016213	NP_057297	Q15650	TRIP4_HUMAN	thyroid hormone receptor interactor 4	172	C4-type.				positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	ligand-dependent nuclear receptor binding|transcription coactivator activity|zinc ion binding			ovary(1)|kidney(1)|skin(1)	3						TCACCCTTGTGATTGCCTGGG	0.498		NaN											0	0	0	0.001168	0	6	84									
SMAD6	4091	broad.mit.edu	37	15	67073574	67073574	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr15:67073574G>A	uc002aqf.2	+	4	2115	c.1192G>A	c.(1192-1194)GAC>AAC	p.D398N	SMAD6_uc010bhx.2_RNA|SMAD6_uc002aqg.2_Missense_Mutation_p.D137N	NM_005585	NP_005576	O43541	SMAD6_HUMAN	SMAD family member 6 isoform 1	398	MH2.				BMP signaling pathway|immune response|negative regulation of apoptosis|negative regulation of BMP signaling pathway|negative regulation of caspase activity|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of SMAD protein complex assembly|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of S phase of mitotic cell cycle|response to laminar fluid shear stress|transforming growth factor beta receptor signaling pathway|zygotic specification of dorsal/ventral axis	cytosol|transcription factor complex	co-SMAD binding|I-SMAD binding|R-SMAD binding|sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity|type I activin receptor binding|type I transforming growth factor beta receptor binding|ubiquitin protein ligase binding			skin(1)	1						CAAGGAGCCCGACGGCGTGTG	0.711		NaN											0	0	0	0.00308	0	5	36									
UACA	55075	broad.mit.edu	37	15	70959792	70959792	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr15:70959792C>G	uc002asr.2	-	16	3335	c.3231G>C	c.(3229-3231)CAG>CAC	p.Q1077H	UACA_uc010uke.1_Missense_Mutation_p.Q968H|UACA_uc002asq.2_Missense_Mutation_p.Q1064H|UACA_uc010bin.1_Missense_Mutation_p.Q1052H	NM_018003	NP_060473	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and	1077	Potential.					cytoskeleton|extracellular region				ovary(2)|pancreas(1)|skin(1)	4						CCGTGTATTTCTGTGACAAGT	0.358		NaN											0	0	0	0.001984	0	7	51									
AGBL1	123624	broad.mit.edu	37	15	86814885	86814885	+	Missense_Mutation	SNP	C	C	G	rs147544569	by1000genomes	TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr15:86814885C>G	uc002blz.1	+	14	1965	c.1885C>G	c.(1885-1887)CTT>GTT	p.L629V	AGBL1_uc002bma.1_Missense_Mutation_p.L360V|AGBL1_uc002bmb.1_Missense_Mutation_p.L323V	NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	629					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						GAAGGAGGCTCTTCTTGGCAA	0.388		NaN											0	0	0	0.003163	0	10	125									
ACAN	176	broad.mit.edu	37	15	89403660	89403660	+	Silent	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr15:89403660C>T	uc010upo.1	+	13	7310	c.6936C>T	c.(6934-6936)CAC>CAT	p.H2312H	ACAN_uc010upp.1_Intron|ACAN_uc002bna.2_Intron	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	2312					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CTGGCGAGCACTGTAACATAG	0.627		NaN											0	0	0	0.000602	0	3	31									
MFGE8	4240	broad.mit.edu	37	15	89442994	89442994	+	Missense_Mutation	SNP	C	C	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr15:89442994C>A	uc002bng.3	-	7	1032	c.919G>T	c.(919-921)GCC>TCC	p.A307S	MFGE8_uc002bnf.3_Missense_Mutation_p.A195S|MFGE8_uc002bnh.3_Intron|MFGE8_uc010bnn.2_Missense_Mutation_p.A299S|MFGE8_uc010upq.1_Missense_Mutation_p.A263S|MFGE8_uc010upr.1_Missense_Mutation_p.A307S	NM_005928	NP_005919	Q08431	MFGM_HUMAN	milk fat globule-EGF factor 8 protein isoform a	307	F5/8 type C 2.				angiogenesis|cell adhesion|interspecies interaction between organisms|single fertilization					ovary(1)	1	Lung NSC(78;0.0392)|all_lung(78;0.077)					AAGTTACGGGCCCCCTGGGTG	0.542		NaN											1	0	8.12818e-05	0.001984	8.50307e-05	7	50									
KIF7	374654	broad.mit.edu	37	15	90189215	90189215	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr15:90189215C>T	uc002bof.2	-	8	1908	c.1831G>A	c.(1831-1833)GAG>AAG	p.E611K	KIF7_uc010upw.1_Missense_Mutation_p.E98K	NM_198525	NP_940927	Q2M1P5	KIF7_HUMAN	kinesin family member 7	611					microtubule-based movement|negative regulation of smoothened signaling pathway|positive regulation of smoothened signaling pathway	cilium	ATP binding|microtubule motor activity|protein binding			ovary(2)|lung(1)	3	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			CTGTTCACCTCAGTCAGCAAC	0.517		NaN											0	0	0	0.00499	0	13	160									
BLM	641	broad.mit.edu	37	15	91333991	91333991	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr15:91333991G>C	uc002bpr.2	+	15	3033	c.2936G>C	c.(2935-2937)AGA>ACA	p.R979T	BLM_uc010uqh.1_Missense_Mutation_p.R979T|BLM_uc010uqi.1_Missense_Mutation_p.R604T|BLM_uc010bnx.2_Missense_Mutation_p.R979T|BLM_uc002bps.1_Missense_Mutation_p.R541T	NM_000057	NP_000048	P54132	BLM_HUMAN	Bloom syndrome protein	979	Helicase C-terminal.				double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			ovary(3)|skin(2)|breast(1)	6	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)			GAATCTGGCAGAGCTGGAAGA	0.438		NaN	Mis|N|F			leukemia|lymphoma|skin squamous cell |other cancers		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Bloom_syndrome				0	0	0	0.004482	0	9	105									
SV2B	9899	broad.mit.edu	37	15	91769716	91769716	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr15:91769716C>T	uc002bqv.2	+	1	614	c.223C>T	c.(223-225)CGG>TGG	p.R75W	SV2B_uc002bqt.2_Missense_Mutation_p.R75W|SV2B_uc010uqv.1_Intron|SV2B_uc002bqu.3_RNA	NM_014848	NP_055663	Q7L1I2	SV2B_HUMAN	synaptic vesicle protein 2B homolog	75	Cytoplasmic (Potential).				neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)|upper_aerodigestive_tract(1)	8	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			GGACAGCCTTCGGGGCCAGAC	0.587		NaN											0	0	0	0.001168	0	4	32									
ITFG3	83986	broad.mit.edu	37	16	312519	312520	+	Missense_Mutation	DNP	TC	TC	CT			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr16:312519_312520TC>CT	uc002cgf.2	+	8	1133_1134	c.938_939TC>CT	c.(937-939)CTC>CCT	p.L313P	ITFG3_uc010bqr.2_RNA|ITFG3_uc002cgg.2_Missense_Mutation_p.L313P|ITFG3_uc010uud.1_RNA|ITFG3_uc002cgh.2_Missense_Mutation_p.L313P	NM_032039	NP_114428	Q9H0X4	ITFG3_HUMAN	integrin alpha FG-GAP repeat containing 3	313	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1		all_cancers(16;0.000129)|all_epithelial(16;0.000206)|Hepatocellular(16;0.00264)|Lung NSC(18;0.0626)|all_lung(18;0.13)				GAGAGCATGCTCAATGCCACCA	0.649		NaN											0	0	0	0.004672	0	11	88									
UNKL	64718	broad.mit.edu	37	16	1417786	1417786	+	Silent	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr16:1417786C>G	uc010brn.1	-	7	798	c.780G>C	c.(778-780)CTG>CTC	p.L260L	UNKL_uc002cln.2_Silent_p.L52L|UNKL_uc002clo.2_Silent_p.L49L|UNKL_uc002clp.2_Silent_p.L52L			Q9H9P5	UNKL_HUMAN	SubName: Full=Putative ubiquitin-protein ligase;          EC=6.3.2.19; Flags: Fragment;	550	Ser-rich.					cytoplasm|nucleus	ligase activity|nucleic acid binding|zinc ion binding				0		Hepatocellular(780;0.0893)				GGCCGGCACTCAGGATGGGGG	0.642		NaN											0	0	0	0.004672	0	3	9									
TBC1D24	57465	broad.mit.edu	37	16	2546157	2546157	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr16:2546157C>G	uc002cql.2	+	2	148	c.8C>G	c.(7-9)TCT>TGT	p.S3C	TBC1D24_uc002cqk.2_Missense_Mutation_p.S3C|TBC1D24_uc002cqm.2_Missense_Mutation_p.S3C|TBC1D24_uc010bsm.2_5'Flank	NM_020705	NP_065756	Q9ULP9	TBC24_HUMAN	TBC1 domain family, member 24	3					neuron projection development	cytoplasm	protein binding|Rab GTPase activator activity				0						GCTATGGACTCTCCAGGATAC	0.597		NaN											0	0	0	0.004656	0	16	109									
NMRAL1	57407	broad.mit.edu	37	16	4511851	4511851	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr16:4511851C>T	uc002cwm.2	-	6	986	c.830G>A	c.(829-831)AGA>AAA	p.R277K	NMRAL1_uc002cwn.2_Missense_Mutation_p.R277K|NMRAL1_uc002cwo.2_Missense_Mutation_p.R277K|NMRAL1_uc002cwp.2_Missense_Mutation_p.R313K	NM_020677	NP_065728	Q9HBL8	NMRL1_HUMAN	NmrA-like family domain containing 1	277						nucleus|perinuclear region of cytoplasm	binding			kidney(1)	1						GGGGTTGAGTCTCAGGGTCAG	0.617		NaN											0	0	0	0.001855	0	12	232									
CLEC16A	23274	broad.mit.edu	37	16	11137897	11137897	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr16:11137897G>A	uc002dao.2	+	16	2013	c.1783G>A	c.(1783-1785)GAA>AAA	p.E595K	CLEC16A_uc002dan.3_Missense_Mutation_p.E577K	NM_015226	NP_056041	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	595								p.0?(1)		ovary(1)|central_nervous_system(1)	2						TGCGAGAGAAGAAAGTGTTCA	0.443		NaN											0	0	0	0.001368	0	10	73									
TXNDC11	51061	broad.mit.edu	37	16	11824584	11824584	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr16:11824584C>G	uc010buu.1	-	4	678	c.616G>C	c.(616-618)GAG>CAG	p.E206Q	TXNDC11_uc002dbg.1_Missense_Mutation_p.E206Q	NM_015914	NP_056998	Q6PKC3	TXD11_HUMAN	thioredoxin domain containing 11	206	Thioredoxin 1.				cell redox homeostasis	endoplasmic reticulum membrane|integral to membrane					0						ACAAACTTCTCAATGTAAACA	0.343		NaN											0	0	0	0.000602	0	5	115									
ABCC1	4363	broad.mit.edu	37	16	16219752	16219752	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr16:16219752C>T	uc010bvi.2	+	26	3978	c.3803C>T	c.(3802-3804)TCA>TTA	p.S1268L	ABCC1_uc010bvj.2_Missense_Mutation_p.S1209L|ABCC1_uc010bvk.2_Missense_Mutation_p.S1212L|ABCC1_uc010bvl.2_Missense_Mutation_p.S1268L|ABCC1_uc010bvm.2_Missense_Mutation_p.S1153L|ABCC1_uc002del.3_Missense_Mutation_p.S1162L	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	1268	Cytoplasmic.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	AAGGAGTATTCAGAGACTGAG	0.537		NaN											0	0	0	0.00308	0	6	54									
MAPK3	5595	broad.mit.edu	37	16	30134420	30134420	+	Silent	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr16:30134420G>A	uc002dws.2	-	1	211	c.111C>T	c.(109-111)GAC>GAT	p.D37D	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|MAPK3_uc002dwr.2_5'Flank|MAPK3_uc002dwv.3_Silent_p.D37D|MAPK3_uc002dwt.2_Silent_p.D37D|MAPK3_uc002dwu.2_RNA|MAPK3_uc010bzp.2_RNA	NM_002746	NP_002737	P27361	MK03_HUMAN	mitogen-activated protein kinase 3 isoform 1	37					activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle|cellular response to mechanical stimulus|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|interleukin-1-mediated signaling pathway|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription initiation from RNA polymerase I promoter	cytosol|nucleoplasm	ATP binding|MAP kinase activity|phosphatase binding				0					Arsenic trioxide(DB01169)|Isoproterenol(DB01064)|Simvastatin(DB00641)|Sulindac(DB00605)	GCGGGCCCACGTCGAACGGCT	0.627		NaN											0	0	0	0.001168	0	4	42									
SRCAP	10847	broad.mit.edu	37	16	30735318	30735318	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr16:30735318C>G	uc002dze.1	+	25	4958	c.4573C>G	c.(4573-4575)CTG>GTG	p.L1525V	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.L1320V|SRCAP_uc010bzz.1_Missense_Mutation_p.L1095V	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	1525	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			TGGTCACCCTCTGTTGTTGGC	0.587		NaN											0	0	0	0.001168	0	5	41									
CHD9	80205	broad.mit.edu	37	16	53338213	53338213	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr16:53338213G>A	uc002ehb.2	+	30	6459	c.6295G>A	c.(6295-6297)GAA>AAA	p.E2099K	CHD9_uc002egy.2_Missense_Mutation_p.E2099K|CHD9_uc002ehc.2_Missense_Mutation_p.E2099K|CHD9_uc002ehf.2_Missense_Mutation_p.E1213K|CHD9_uc010cbw.2_Intron|CHD9_uc002ehg.1_Missense_Mutation_p.E105K	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	2099					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				TGGAAAATGTGAAACAGACAG	0.448		NaN											0	0	0	0.004672	0	3	23									
FUK	197258	broad.mit.edu	37	16	70500855	70500855	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr16:70500855C>T	uc002eyy.2	+	6	540	c.482C>T	c.(481-483)CCT>CTT	p.P161L	FUK_uc010vmb.1_Missense_Mutation_p.P144L|FUK_uc010cft.2_Missense_Mutation_p.P193L|FUK_uc002eyz.2_Intron	NM_145059	NP_659496	Q8N0W3	FUK_HUMAN	fucokinase	161						cytoplasm	ATP binding|fucokinase activity			ovary(1)	1		Ovarian(137;0.0694)				CCTGCAAATCCTGGTGAGCCT	0.647		NaN											0	0	0	0.008291	0	9	77									
PLCG2	5336	broad.mit.edu	37	16	81929432	81929432	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr16:81929432G>C	uc002fgt.2	+	13	1245	c.1093G>C	c.(1093-1095)GAT>CAT	p.D365H	PLCG2_uc010chg.1_Missense_Mutation_p.D365H	NM_002661	NP_002652	P16885	PLCG2_HUMAN	phospholipase C, gamma 2	365	PI-PLC X-box.				intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			large_intestine(4)|lung(2)|ovary(1)|skin(1)	8						GGACGGGCCCGATGGGAAGCC	0.607		NaN											0	0	0	0.00308	0	6	87									
OR1D2	4991	broad.mit.edu	37	17	2995465	2995465	+	Missense_Mutation	SNP	T	T	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:2995465T>A	uc010vrb.1	-	1	826	c.826A>T	c.(826-828)ATG>TTG	p.M276L		NM_002548	NP_002539	P34982	OR1D2_HUMAN	olfactory receptor, family 1, subfamily D,	276	Helical; Name=7; (Potential).				cellular component movement|chemotaxis|protein import into nucleus, translocation|sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1						ACAGCATACATCACTGTGGCT	0.483		NaN											0	0	0	0.000978	0	9	113									
ASGR2	433	broad.mit.edu	37	17	7017471	7017471	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:7017471C>T	uc002gep.3	-	2	354	c.89G>A	c.(88-90)AGG>AAG	p.R30K	ASGR2_uc002gem.1_5'UTR|ASGR2_uc002gen.1_Intron|ASGR2_uc002geo.1_Missense_Mutation_p.R30K|ASGR2_uc002ger.3_Missense_Mutation_p.R30K|ASGR2_uc002geq.3_Intron|ASGR2_uc010clw.2_Intron|ASGR2_uc010vtl.1_Intron	NM_001181	NP_001172	P07307	ASGR2_HUMAN	asialoglycoprotein receptor 2 isoform a	30	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|endocytosis	focal adhesion|integral to membrane|nucleolus	asialoglycoprotein receptor activity|protein binding|sugar binding			ovary(1)	1					Antihemophilic Factor(DB00025)	GGGATTCAGCCTGCGAGTGCC	0.493		NaN											0	0	0	0.001855	0	11	115									
DVL2	1856	broad.mit.edu	37	17	7131015	7131015	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:7131015G>A	uc002gez.1	-	11	1472	c.1190C>T	c.(1189-1191)TCC>TTC	p.S397F	DVL2_uc010vtr.1_Missense_Mutation_p.S391F	NM_004422	NP_004413	O14641	DVL2_HUMAN	dishevelled 2	397					canonical Wnt receptor signaling pathway involved in regulation of cell proliferation|intracellular signal transduction|neural tube closure|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|segment specification|transcription from RNA polymerase II promoter	cytosol|nucleus|plasma membrane	frizzled binding|identical protein binding|signal transducer activity			lung(1)|kidney(1)	2						GCTCATGGAGGAGGAACCTGG	0.597		NaN											0	0	0	0.004672	0	3	37									
SAT2	112483	broad.mit.edu	37	17	7530510	7530510	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:7530510G>C	uc002gic.2	-	3	394	c.153C>G	c.(151-153)TTC>TTG	p.F51L	SHBG_uc010cmo.2_Intron|SHBG_uc010cmp.2_Intron|SHBG_uc010cmq.2_Intron|SHBG_uc010cmr.2_Intron|SHBG_uc010cms.2_Intron|SHBG_uc010cmt.2_Intron|SHBG_uc010cmu.2_Intron|SAT2_uc002gib.1_RNA|SHBG_uc010cmz.2_5'Flank|SHBG_uc010cmv.2_5'Flank|SHBG_uc010cmw.2_5'Flank|SHBG_uc010cmx.2_5'Flank|SHBG_uc010cmy.2_5'Flank|SHBG_uc002gid.3_5'Flank|SHBG_uc002gie.2_5'Flank|SHBG_uc010cnd.2_5'Flank|SHBG_uc010cna.2_5'Flank|SHBG_uc010vue.1_5'Flank|SHBG_uc010vuf.1_5'Flank|SHBG_uc010cnb.2_5'Flank|SHBG_uc010cnc.2_5'Flank	NM_133491	NP_597998	Q96F10	SAT2_HUMAN	diamine N-acetyltransferase 2	51	N-acetyltransferase.					cytoplasm	diamine N-acetyltransferase activity	p.?(1)			0				READ - Rectum adenocarcinoma(115;0.166)	Spermine(DB00127)	AACAGTGATAGAAAGGATTGT	0.547		NaN											0	0	0	0.00308	0	7	80									
DNAH2	146754	broad.mit.edu	37	17	7643790	7643790	+	Missense_Mutation	SNP	T	T	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:7643790T>C	uc002giu.1	+	9	1443	c.1429T>C	c.(1429-1431)TCA>CCA	p.S477P	DNAH2_uc002git.2_Missense_Mutation_p.S559P|DNAH2_uc010vuk.1_Missense_Mutation_p.S477P	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	477	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CCTGATCACCTCAGCCTTCGA	0.667		NaN											0	0	0	0.004007	0	13	219									
DNAH2	146754	broad.mit.edu	37	17	7674653	7674653	+	Silent	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:7674653C>T	uc002giu.1	+	27	4382	c.4368C>T	c.(4366-4368)ATC>ATT	p.I1456I		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	1456	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CTCAGAATATCTTCCTAGGAG	0.512		NaN											0	0	0	0.00632	0	20	152									
SPDYE4	388333	broad.mit.edu	37	17	8659711	8659711	+	Silent	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:8659711C>T	uc010cnz.1	-	3	561	c.384G>A	c.(382-384)CTG>CTA	p.L128L		NM_001128076	NP_001121548	A6NLX3	SPDE4_HUMAN	speedy homolog E4	128											0						CTGACACCCTCAGGTCTTTGT	0.527		NaN											0	0	0	0.004007	0	14	156									
TOM1L2	146691	broad.mit.edu	37	17	17754256	17754256	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:17754256G>A	uc002grz.3	-	13	1446	c.1289C>T	c.(1288-1290)GCG>GTG	p.A430V	TOM1L2_uc002gry.3_Missense_Mutation_p.A380V|TOM1L2_uc010vwy.1_Missense_Mutation_p.A406V|TOM1L2_uc010cpr.2_Missense_Mutation_p.A385V|TOM1L2_uc010vwz.1_Missense_Mutation_p.A311V|TOM1L2_uc010vxa.1_Intron|TOM1L2_uc002grv.3_Missense_Mutation_p.A163V	NM_001082968	NP_001076437	Q6ZVM7	TM1L2_HUMAN	target of myb1-like 2 isoform 3	430					intracellular protein transport	intracellular					0	all_neural(463;0.228)					AGATGGCTGCGCAACGGGGAT	0.587		NaN											0	0	0	0.004007	0	14	121									
EPN2	22905	broad.mit.edu	37	17	19186762	19186762	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:19186762G>C	uc002gvd.3	+	3	778	c.330G>C	c.(328-330)CAG>CAC	p.Q110H	EPN2_uc002gvc.2_Missense_Mutation_p.Q110H|EPN2_uc010vyn.1_Missense_Mutation_p.Q110H|EPN2_uc010cql.1_Intron|EPN2_uc002gve.3_Missense_Mutation_p.Q110H|EPN2_uc002gvf.3_Intron|EPN2_uc010vyo.1_Intron|EPN2_uc002gvg.1_Missense_Mutation_p.Q110H|EPN2_uc010vyp.1_Missense_Mutation_p.Q110H|EPN2_uc010vyq.1_Missense_Mutation_p.Q110H|EPN2_uc002gvh.1_Missense_Mutation_p.Q110H	NM_014964	NP_055779	O95208	EPN2_HUMAN	epsin 2 isoform b	110	ENTH.				endocytosis		lipid binding			skin(1)	1	all_cancers(12;3.11e-05)|all_epithelial(12;0.00121)|Hepatocellular(7;0.00345)|Breast(13;0.143)					AGGACTTCCAGTACATTGACC	0.567		NaN											0	0	0	0.004482	0	7	87									
ULK2	9706	broad.mit.edu	37	17	19689285	19689285	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:19689285C>G	uc002gwm.3	-	21	2725	c.2216G>C	c.(2215-2217)TGT>TCT	p.C739S	ULK2_uc002gwn.2_Missense_Mutation_p.C739S	NM_001142610	NP_001136082	Q8IYT8	ULK2_HUMAN	unc-51-like kinase 2	739					signal transduction		ATP binding|protein binding|protein serine/threonine kinase activity			skin(2)|large_intestine(1)|stomach(1)	4	all_cancers(12;4.97e-05)|all_epithelial(12;0.00362)|Breast(13;0.186)					CATGTGGGTACAAGTGGGGGC	0.478		NaN											0	0	0	0.001984	0	7	62									
NLK	51701	broad.mit.edu	37	17	26449721	26449721	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:26449721G>A	uc010crj.2	+	2	763	c.551G>A	c.(550-552)CGG>CAG	p.R184Q	NLK_uc010cri.1_RNA	NM_016231	NP_057315	Q9UBE8	NLK_HUMAN	nemo like kinase	184	Protein kinase.				intracellular protein kinase cascade|negative regulation of Wnt receptor signaling pathway|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|serine phosphorylation of STAT3 protein|transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway|Wnt receptor signaling pathway	cytoplasm|nucleus	ATP binding|magnesium ion binding|MAP kinase activity|SH2 domain binding|transcription factor binding|ubiquitin protein ligase binding			ovary(1)|lung(1)|central_nervous_system(1)	3	all_lung(13;0.000343)|Lung NSC(42;0.00184)			UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		AGGGTCTTCCGGGAATTGAAG	0.393		NaN											0	0	0	0.00308	0	7	90									
ATAD5	79915	broad.mit.edu	37	17	29220310	29220310	+	Splice_Site	SNP	A	A	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:29220310A>T	uc002hfs.1	+	21	4787	c.4441_splice	c.e21-2	p.H1481_splice		NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5						response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				ATTGTTTTTCAGCACAAAATC	0.294		NaN											0	0	0	0.00361	0	61	253									
RAB11FIP4	84440	broad.mit.edu	37	17	29857477	29857477	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:29857477C>T	uc002hgn.1	+	14	2016	c.1787C>T	c.(1786-1788)TCG>TTG	p.S596L	RAB11FIP4_uc002hgo.2_Missense_Mutation_p.S494L	NM_032932	NP_116321	Q86YS3	RFIP4_HUMAN	RAB11 family interacting protein 4 (class II)	596	Potential.|Necessary for interaction with RAB11A, subcellular location, homo- or heterooligomerization.|FIP-RBD.				cytokinesis|interspecies interaction between organisms|protein transport	cleavage furrow|endocytic vesicle|midbody|recycling endosome membrane	ADP-ribosylation factor binding|calcium ion binding|protein homodimerization activity|Rab GTPase binding			skin(1)	1		all_cancers(10;3.62e-13)|all_epithelial(10;0.000387)|all_lung(9;0.0132)|Breast(31;0.014)|all_hematologic(16;0.015)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0259)|Ovarian(249;0.0423)|Lung NSC(157;0.066)				GACACCGCCTCGCGCGATGAG	0.582		NaN											0	0	0	0.001855	0	11	146									
CCT6B	10693	broad.mit.edu	37	17	33285634	33285634	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:33285634G>A	uc002hig.2	-	3	375	c.281C>T	c.(280-282)TCA>TTA	p.S94L	CCT6B_uc010ctg.2_Missense_Mutation_p.S94L|CCT6B_uc010wcc.1_Intron|ZNF830_uc002hih.3_5'Flank	NM_006584	NP_006575	Q92526	TCPW_HUMAN	chaperonin containing TCP1, subunit 6B	94				S -> T (in Ref. 1; BAA11347).	chaperone-mediated protein complex assembly|protein folding|spermatogenesis	cytoplasm	ATP binding|protein transporter activity|unfolded protein binding			pancreas(1)	1		Ovarian(249;0.17)				TAGAACATTTGAAGTAGTACC	0.353		NaN											0	0	0	0.000602	0	4	62									
KRT13	3860	broad.mit.edu	37	17	39659272	39659272	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:39659272G>A	uc002hwu.1	-	4	877	c.814C>T	c.(814-816)CGC>TGC	p.R272C	KRT13_uc002hwv.1_Missense_Mutation_p.R272C|KRT13_uc002hww.2_Missense_Mutation_p.R165C|KRT13_uc010wfr.1_Missense_Mutation_p.R165C|KRT13_uc010cxo.2_Missense_Mutation_p.R272C|KRT13_uc002hwx.1_Missense_Mutation_p.R260C	NM_153490	NP_705694	P13646	K1C13_HUMAN	keratin 13 isoform a	272	Linker 12.|Rod.				epidermis development	intermediate filament	structural molecule activity			ovary(2)|skin(2)|pancreas(1)	5		Breast(137;0.000286)				GCCAGCACGCGGGTCAGGTCA	0.602		NaN											0	0	0	0.00361	0	45	701									
KRT17	3872	broad.mit.edu	37	17	39777261	39777261	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:39777261G>C	uc002hxh.2	-	5	1038	c.917C>G	c.(916-918)ACC>AGC	p.T306S	JUP_uc010wfs.1_Intron	NM_000422	NP_000413	Q04695	K1C17_HUMAN	keratin 17	306	Coil 2.|Rod.				epidermis development	cytoplasm|intermediate filament	protein binding|structural constituent of cytoskeleton			ovary(1)|skin(1)	2		Breast(137;0.000307)				GGCCTGCATGGTGCGCCGGAG	0.602		NaN							Steatocystoma_Multiplex				0	0	0	0.00245	0	11	99									
SLC25A39	51629	broad.mit.edu	37	17	42397441	42397441	+	Silent	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:42397441G>A	uc002ign.2	-	12	1162	c.1008C>T	c.(1006-1008)ATC>ATT	p.I336I	SLC25A39_uc002igm.2_Silent_p.I328I|SLC25A39_uc002igo.2_Silent_p.I328I|SLC25A39_uc010wiw.1_Silent_p.I313I|SLC25A39_uc010czu.2_Silent_p.I204I	NM_001143780	NP_001137252	Q9BZJ4	S2539_HUMAN	solute carrier family 25, member 39 isoform a	336	Solcar 3.|Helical; Name=6; (Potential).				heme biosynthetic process|transport	integral to membrane|mitochondrial inner membrane				upper_aerodigestive_tract(1)	1		Prostate(33;0.0233)		BRCA - Breast invasive adenocarcinoma(366;0.189)		TGCTGATCATGATGGCACAGG	0.617		NaN											0	0	0	0.007413	0	15	130									
SPAG9	9043	broad.mit.edu	37	17	49043730	49043730	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:49043730G>A	uc002itc.2	-	30	4078	c.3869C>T	c.(3868-3870)TCA>TTA	p.S1290L	SPAG9_uc002itb.2_Missense_Mutation_p.S1276L|SPAG9_uc002itd.2_Missense_Mutation_p.S1280L|SPAG9_uc002ita.2_Missense_Mutation_p.S1146L	NM_001130528	NP_001124000	O60271	JIP4_HUMAN	sperm associated antigen 9 isoform 1	1290					positive regulation of cell migration|positive regulation of muscle cell differentiation|retrograde transport, endosome to Golgi|spermatogenesis	acrosomal vesicle|integral to membrane|perinuclear region of cytoplasm				lung(4)|breast(1)	5			BRCA - Breast invasive adenocarcinoma(22;4.24e-07)			AAGAAGTTCTGATTCTCCACC	0.418		NaN											0	0	0	0.003163	0	12	160									
NOG	9241	broad.mit.edu	37	17	54672146	54672146	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:54672146G>A	uc002iup.2	+	1	1087	c.562G>A	c.(562-564)GAG>AAG	p.E188K		NM_005450	NP_005441	Q13253	NOGG_HUMAN	noggin precursor	188					BMP signaling pathway|cartilage development|cell differentiation in hindbrain|dorsal/ventral pattern formation|embryonic digit morphogenesis|embryonic skeletal joint morphogenesis|epithelial to mesenchymal transition|fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation|middle ear morphogenesis|negative regulation of astrocyte differentiation|negative regulation of BMP signaling pathway|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of cytokine activity|negative regulation of osteoblast differentiation|osteoblast differentiation|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of glomerulus development|somatic stem cell maintenance|wound healing	extracellular space	cytokine binding|protein homodimerization activity				0	Breast(9;5.24e-08)					CTCCGTGCCCGAGGGCATGGT	0.687		NaN											0	0	0	0.000602	0	3	33									
MED13	9969	broad.mit.edu	37	17	60032756	60032756	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:60032756G>C	uc002izo.2	-	26	6032	c.5955C>G	c.(5953-5955)TTC>TTG	p.F1985L		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	1985					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						TGTTGGGATTGAAAGCTAAAT	0.244		NaN											0	0	0	0.008291	0	9	53									
MED13	9969	broad.mit.edu	37	17	60059762	60059762	+	Nonsense_Mutation	SNP	G	G	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:60059762G>T	uc002izo.2	-	16	3679	c.3602C>A	c.(3601-3603)TCA>TAA	p.S1201*		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	1201					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						TCCAAAGGGTGAAAATAAATT	0.388		NaN											1	0	1.06961e-07	0.00308	1.1503e-07	8	134									
MED13	9969	broad.mit.edu	37	17	60059866	60059866	+	Silent	SNP	G	G	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:60059866G>T	uc002izo.2	-	16	3575	c.3498C>A	c.(3496-3498)CTC>CTA	p.L1166L		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	1166					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						AGGTAGCCCTGAGAGCTTCAA	0.348		NaN											1	0	2.27111e-07	0.001368	2.43194e-07	13	134									
CD300LB	124599	broad.mit.edu	37	17	72518922	72518922	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:72518922G>C	uc002jkx.2	-	4	685	c.672C>G	c.(670-672)ATC>ATG	p.I224M		NM_174892	NP_777552	A8K4G0	CLM7_HUMAN	CD300 molecule-like family member b	187	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(1)	1						AGTTCATGTAGATAGGCTGTT	0.537		NaN											0	0	0	0.000978	0	9	116									
TMC8	147138	broad.mit.edu	37	17	76136966	76136966	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:76136966G>C	uc002jup.2	+	16	2336	c.1954G>C	c.(1954-1956)GAG>CAG	p.E652Q	TMC8_uc002juq.2_Missense_Mutation_p.E429Q	NM_152468	NP_689681	Q8IU68	TMC8_HUMAN	transmembrane channel-like 8	652	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)|OV - Ovarian serous cystadenocarcinoma(97;0.192)			ACTGCTGCCGGAGCCAGGCCC	0.682		NaN							Epidermodysplasia_Verruciformis_Familial_Clustering_of				0	0	0	0.009096	0	3	34									
DNAH17	8632	broad.mit.edu	37	17	76548800	76548800	+	Missense_Mutation	SNP	T	T	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:76548800T>C	uc002jvv.1	-	11	1478	c.1372A>G	c.(1372-1374)ACA>GCA	p.T458A						RecName: Full=Dynein heavy chain 17, axonemal; AltName: Full=Axonemal beta dynein heavy chain 17; AltName: Full=Ciliary dynein heavy chain 17; AltName: Full=Ciliary dynein heavy chain-like protein 1; AltName: Full=Axonemal dynein heavy chain-like protein 1; AltName: Full=Dynein light chain 2, axonemal;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CAGAATAATGTCGTTTCAGCG	0.428		NaN											0	0	0	0.000978	0	11	279									
ABHD3	171586	broad.mit.edu	37	18	19239256	19239256	+	Silent	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr18:19239256C>T	uc002ktl.2	-	6	857	c.717G>A	c.(715-717)TTG>TTA	p.L239L	ABHD3_uc002ktm.2_Silent_p.L186L|ABHD3_uc010xao.1_RNA|ABHD3_uc002ktk.2_Silent_p.L44L|ABHD3_uc002ktn.2_Silent_p.L16L	NM_138340	NP_612213	Q8WU67	ABHD3_HUMAN	alpha/beta hydrolase domain containing protein	239						integral to membrane	carboxylesterase activity			central_nervous_system(1)	1						CAGCTGCCATCAAAGGCGTTT	0.393		NaN											0	0	0	0.001984	0	7	108									
SLC39A6	25800	broad.mit.edu	37	18	33706705	33706705	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr18:33706705C>G	uc010dmy.2	-	2	556	c.266G>C	c.(265-267)AGA>ACA	p.R89T	SLC39A6_uc002kzj.2_Intron	NM_012319	NP_036451	Q13433	S39A6_HUMAN	solute carrier family 39 (zinc transporter),	89	Extracellular (Potential).					integral to membrane|lamellipodium membrane	zinc ion transmembrane transporter activity			ovary(1)|pancreas(1)	2						TATATGGATTCTTTTAATCTT	0.169		NaN											0	0	0	0.009096	0	4	27									
SYT4	6860	broad.mit.edu	37	18	40850420	40850420	+	Silent	SNP	G	G	A	rs117568424	byFrequency	TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr18:40850420G>A	uc002law.2	-	4	1533	c.1164C>T	c.(1162-1164)ATC>ATT	p.I388I	SYT4_uc010dng.2_RNA|SYT4_uc010xcm.1_Silent_p.I370I|SYT4_uc010dnh.2_RNA	NM_020783	NP_065834	Q9H2B2	SYT4_HUMAN	synaptotagmin IV	388	C2 2.|Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			skin(5)	5						CTAACTGCCCGATTACCTCAT	0.473		NaN											0	0	0	0.001168	0	6	145									
ACAA2	10449	broad.mit.edu	37	18	47320775	47320775	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr18:47320775G>A	uc002ldw.3	-	5	849	c.452C>T	c.(451-453)TCA>TTA	p.S151L	ACAA2_uc002ldx.3_Missense_Mutation_p.S148L	NM_006111	NP_006102	P42765	THIM_HUMAN	acetyl-coenzyme A acyltransferase 2	151					anti-apoptosis|cholesterol biosynthetic process		acetyl-CoA C-acyltransferase activity|protein binding			ovary(1)	1						ATCTGTTAATGATACCCATAA	0.328		NaN											0	0	0	0.009096	0	3	44									
ZNF407	55628	broad.mit.edu	37	18	72343115	72343115	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr18:72343115C>T	uc002llw.2	+	1	197	c.140C>T	c.(139-141)TCT>TTT	p.S47F	ZNF407_uc010xfc.1_Missense_Mutation_p.S47F|ZNF407_uc010dqu.1_Missense_Mutation_p.S47F|ZNF407_uc002llu.2_Missense_Mutation_p.S46F	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	47					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		CCTGAGAATTCTATGGGCAAA	0.388		NaN											0	0	0	0.004672	0	3	33									
ZNF407	55628	broad.mit.edu	37	18	72343658	72343658	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr18:72343658C>T	uc002llw.2	+	1	740	c.683C>T	c.(682-684)TCA>TTA	p.S228L	ZNF407_uc010xfc.1_Missense_Mutation_p.S228L|ZNF407_uc010dqu.1_Missense_Mutation_p.S228L|ZNF407_uc002llu.2_Missense_Mutation_p.S227L	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	228	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		GAGAGCAGCTCAGCACTACAT	0.438		NaN											0	0	0	0.004007	0	17	151									
ZNF407	55628	broad.mit.edu	37	18	72343946	72343946	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr18:72343946G>A	uc002llw.2	+	1	1028	c.971G>A	c.(970-972)GGA>GAA	p.G324E	ZNF407_uc010xfc.1_Missense_Mutation_p.G324E|ZNF407_uc010dqu.1_Missense_Mutation_p.G324E|ZNF407_uc002llu.2_Missense_Mutation_p.G323E	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	324					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		CGAAATGTGGGAAGCACGTTT	0.343		NaN											0	0	0	0.001368	0	10	114									
ELAVL1	1994	broad.mit.edu	37	19	8056716	8056716	+	Splice_Site	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:8056716C>G	uc002mjb.2	-	2	152	c.-15_splice	c.e2-1			NM_001419	NP_001410	Q15717	ELAV1_HUMAN	ELAV-like 1						3'-UTR-mediated mRNA stabilization|multicellular organismal development	cytoplasm|nucleoplasm	identical protein binding|mRNA binding|nucleotide binding				0						TTTCAAAAATCTGCCAAGAGA	0.373		NaN											0	0	0	0.001984	0	6	30									
CC2D1A	54862	broad.mit.edu	37	19	14028882	14028882	+	Splice_Site	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:14028882G>A	uc002mxo.2	+	7	1048	c.749_splice	c.e7-1	p.G250_splice	CC2D1A_uc002mxn.2_Splice_Site_p.G149_splice|CC2D1A_uc002mxp.2_Splice_Site_p.G250_splice|CC2D1A_uc010dzh.2_Splice_Site|CC2D1A_uc002mxq.1_5'Flank	NM_017721	NP_060191	Q6P1N0	C2D1A_HUMAN	coiled-coil and C2 domain containing 1A						positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|plasma membrane	DNA binding|signal transducer activity				0			OV - Ovarian serous cystadenocarcinoma(19;3.49e-23)			CTCCCTTCCAGGTCCCTGCAG	0.517		NaN											0	0	0	0.006214	0	7	42									
OR7C1	26664	broad.mit.edu	37	19	14910386	14910386	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:14910386G>A	uc010xnz.1	-	1	563	c.563C>T	c.(562-564)GCC>GTC	p.A188V		NM_198944	NP_945182	O76099	OR7C1_HUMAN	olfactory receptor, family 7, subfamily C,	188	Extracellular (Potential).				sensory perception of smell|spermatogenesis	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2						GTCAGAACAGGCGAGCTTCAG	0.423		NaN											0	0	0	0.000978	0	8	113									
OR7C1	26664	broad.mit.edu	37	19	14910475	14910475	+	Silent	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:14910475G>C	uc010xnz.1	-	1	474	c.474C>G	c.(472-474)CTC>CTG	p.L158L		NM_198944	NP_945182	O76099	OR7C1_HUMAN	olfactory receptor, family 7, subfamily C,	158	Helical; Name=4; (Potential).				sensory perception of smell|spermatogenesis	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2						TCAAGGTCTCGAGCAGGGAAC	0.522		NaN											0	0	0	0.004482	0	8	157									
OR7C1	26664	broad.mit.edu	37	19	14910879	14910879	+	Missense_Mutation	SNP	G	G	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:14910879G>T	uc010xnz.1	-	1	70	c.70C>A	c.(70-72)CAG>AAG	p.Q24K		NM_198944	NP_945182	O76099	OR7C1_HUMAN	olfactory receptor, family 7, subfamily C,	24	Extracellular (Potential).				sensory perception of smell|spermatogenesis	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2						AGAATGAACTGAATCTCTGAC	0.468		NaN											1	0	3.59834e-05	0.001168	3.78812e-05	6	159									
OR7A17	26333	broad.mit.edu	37	19	14992003	14992003	+	Silent	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:14992003G>C	uc010xob.1	-	1	165	c.165C>G	c.(163-165)CTC>CTG	p.L55L		NM_030901	NP_112163	O14581	OR7AH_HUMAN	olfactory receptor, family 7, subfamily A,	55	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Ovarian(108;0.203)					TGGGGGTGTGGAGGTGGGAGT	0.498		NaN											0	0	0	0.00308	0	6	81									
AKAP8L	26993	broad.mit.edu	37	19	15508413	15508413	+	Silent	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:15508413C>T	uc002naw.1	-	11	1422	c.1323G>A	c.(1321-1323)AAG>AAA	p.K441K	AKAP8L_uc002nax.1_RNA|AKAP8L_uc010xoh.1_Silent_p.K380K	NM_014371	NP_055186	Q9ULX6	AKP8L_HUMAN	A kinase (PRKA) anchor protein 8-like	441						cytoplasm|nuclear matrix	DEAD/H-box RNA helicase binding|DNA binding|zinc ion binding			ovary(1)	1						CCTCTGTCTTCTTGGTCTTGT	0.502		NaN											0	0	0	0.001984	0	5	38									
CRLF1	9244	broad.mit.edu	37	19	18709341	18709341	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:18709341C>T	uc010ebt.1	-	4	792	c.598G>A	c.(598-600)GAC>AAC	p.D200N		NM_004750	NP_004741	O75462	CRLF1_HUMAN	cytokine receptor-like factor 1 precursor	200	Fibronectin type-III 1.				negative regulation of neuron apoptosis|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	cytokine binding|protein heterodimerization activity|receptor activity			central_nervous_system(1)	1						AGAGCCAGGTCCTTGGGGATG	0.622		NaN											0	0	0	0.007413	0	13	148									
CRLF1	9244	broad.mit.edu	37	19	18709383	18709383	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:18709383C>T	uc010ebt.1	-	4	750	c.556G>A	c.(556-558)GAG>AAG	p.E186K		NM_004750	NP_004741	O75462	CRLF1_HUMAN	cytokine receptor-like factor 1 precursor	186	Fibronectin type-III 1.				negative regulation of neuron apoptosis|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	cytokine binding|protein heterodimerization activity|receptor activity			central_nervous_system(1)	1						GTGTGGTACTCCTCACATGTG	0.632		NaN											0	0	0	0.001882	0	20	150									
CRLF1	9244	broad.mit.edu	37	19	18709656	18709656	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:18709656C>G	uc010ebt.1	-	3	647	c.453G>C	c.(451-453)TTG>TTC	p.L151F		NM_004750	NP_004741	O75462	CRLF1_HUMAN	cytokine receptor-like factor 1 precursor	151	Fibronectin type-III 1.				negative regulation of neuron apoptosis|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	cytokine binding|protein heterodimerization activity|receptor activity			central_nervous_system(1)	1						AGCGGCAGGTCAAGTCCTTCA	0.607		NaN											0	0	0	0.000978	0	8	90									
C19orf12	83636	broad.mit.edu	37	19	30199175	30199175	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:30199175G>A	uc002nsk.2	-	2	577	c.146C>T	c.(145-147)CCG>CTG	p.P49L	C19orf12_uc002nsj.2_Missense_Mutation_p.P60L|C19orf12_uc002nsl.2_Intron|C19orf12_uc002nsm.2_RNA	NM_031448	NP_113636	Q9NSK7	CS012_HUMAN	hypothetical protein LOC83636 isoform 2	49	Helical; (Potential).					integral to membrane					0	Ovarian(5;0.000567)|Breast(6;0.0203)|Esophageal squamous(110;0.239)		UCEC - Uterine corpus endometrioid carcinoma (4;2.65e-06)|STAD - Stomach adenocarcinoma(5;1.7e-06)|Lung(7;0.0435)|LUAD - Lung adenocarcinoma(5;0.0989)|BRCA - Breast invasive adenocarcinoma(6;0.183)			GGCGAGTCCCGGTGGGCCGCC	0.572		NaN											0	0	0	0.002836	0	23	106									
RGS9BP	388531	broad.mit.edu	37	19	33167295	33167295	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:33167295G>C	uc002ntp.1	+	1	983	c.126G>C	c.(124-126)AAG>AAC	p.K42N	ANKRD27_uc002ntn.1_5'Flank|ANKRD27_uc002nto.1_5'Flank	NM_207391	NP_997274	Q6ZS82	R9BP_HUMAN	RGS9 anchor protein	42	Potential.|Cytoplasmic (Potential).				negative regulation of signal transduction	integral to membrane				central_nervous_system(1)	1	Esophageal squamous(110;0.137)					AGCTGCAAAAGACGCGCCAGA	0.701		NaN											0	0	0	0.004672	0	3	27									
ZFP30	22835	broad.mit.edu	37	19	38126715	38126715	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:38126715C>T	uc002ogv.1	-	6	1243	c.727G>A	c.(727-729)GAA>AAA	p.E243K	ZFP30_uc002ogw.1_Missense_Mutation_p.E243K|ZFP30_uc002ogx.1_Missense_Mutation_p.E243K|ZFP30_uc010xtt.1_Missense_Mutation_p.E242K	NM_014898	NP_055713	Q9Y2G7	ZFP30_HUMAN	zinc finger protein 30 homolog	243	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TCTTTACATTCATACGGCTTC	0.388		NaN											0	0	0	0.010504	0	19	52									
KCNK6	9424	broad.mit.edu	37	19	38817601	38817601	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:38817601C>T	uc002oic.2	+	2	801	c.691C>T	c.(691-693)CGG>TGG	p.R231W	KCNK6_uc002oid.2_Missense_Mutation_p.R97W	NM_004823	NP_004814	Q9Y257	KCNK6_HUMAN	potassium channel, subfamily K, member 6	231						voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(1)	1	all_cancers(60;5.83e-07)		Lung(45;0.00047)|LUSC - Lung squamous cell carcinoma(53;0.000613)		Ibutilide(DB00308)|Quinidine(DB00908)	CCAGCCCTACCGGGCCCTCTA	0.627		NaN											0	0	0	0.00499	0	16	125									
PLEKHG2	64857	broad.mit.edu	37	19	39915786	39915786	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:39915786C>T	uc010xuz.1	+	19	4338	c.4013C>T	c.(4012-4014)ACG>ATG	p.T1338M	PLEKHG2_uc010xuy.1_Intron|PLEKHG2_uc002olj.2_Intron|PLEKHG2_uc010xva.1_Missense_Mutation_p.T1116M	NM_022835	NP_073746	Q9H7P9	PKHG2_HUMAN	common-site lymphoma/leukemia guanine nucleotide	1338					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			skin(2)|pancreas(1)|breast(1)	4	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			TATGCCACGACGGTTAACATC	0.692		NaN											0	0	0	0.000602	0	4	40									
ATP1A3	478	broad.mit.edu	37	19	42490310	42490310	+	Silent	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:42490310C>T	uc002osg.2	-	5	583	c.429G>A	c.(427-429)AAG>AAA	p.K143K	ATP1A3_uc010xwf.1_Silent_p.K154K|ATP1A3_uc010xwg.1_Silent_p.K113K|ATP1A3_uc010xwh.1_Silent_p.K156K|ATP1A3_uc002osh.2_Silent_p.K143K	NM_152296	NP_689509	P13637	AT1A3_HUMAN	Na+/K+ -ATPase alpha 3 subunit	143	Cytoplasmic (Potential).				ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(1)|pancreas(1)	2						TCTTGGAGCTCTTGGCCTCCT	0.607		NaN											0	0	0	0.006122	0	15	155									
PSG8	440533	broad.mit.edu	37	19	43259327	43259327	+	Missense_Mutation	SNP	C	C	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:43259327C>A	uc002ouo.2	-	4	899	c.801G>T	c.(799-801)GAG>GAT	p.E267D	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG8_uc010eim.2_Intron|PSG8_uc002oui.2_Missense_Mutation_p.E106D|PSG8_uc002ouh.2_Missense_Mutation_p.E267D|PSG8_uc010ein.2_Missense_Mutation_p.E145D|PSG8_uc002ouj.3_Missense_Mutation_p.E49D|PSG8_uc002ouk.3_Missense_Mutation_p.E106D|PSG8_uc002oul.3_Missense_Mutation_p.E267D|PSG8_uc002oum.3_Missense_Mutation_p.E174D|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Missense_Mutation_p.E174D	NM_182707	NP_874366	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8 isoform	267	Ig-like C2-type 2.					extracellular region					0		Prostate(69;0.00899)				AGGTGTAGTTCTCACTCTTAG	0.483		NaN											1	0	4.59853e-10	0.005443	5.02115e-10	17	253									
ZNF285	26974	broad.mit.edu	37	19	44891132	44891132	+	Silent	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:44891132C>T	uc002ozd.3	-	4	1362	c.1275G>A	c.(1273-1275)GAG>GAA	p.E425E	ZFP112_uc010xwz.1_Intron|ZNF285_uc010xxa.1_Silent_p.E432E	NM_152354	NP_689567	Q96NJ3	ZN285_HUMAN	zinc finger protein 285	425					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(2)	4						TATATGGTTTCTCCCCTGTGT	0.493		NaN											0	0	0	0.006214	0	8	67									
SFRS16	11129	broad.mit.edu	37	19	45563675	45563675	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:45563675G>A	uc002pak.2	+	9	837	c.739G>A	c.(739-741)GAG>AAG	p.E247K	SFRS16_uc002pal.2_RNA|SFRS16_uc010xxh.1_Missense_Mutation_p.E185K|SFRS16_uc002pam.2_Missense_Mutation_p.E247K|SFRS16_uc002pan.1_RNA	NM_007056	NP_008987	Q8N2M8	CLASR_HUMAN	splicing factor, arginine/serine-rich 16	247					mRNA processing|RNA splicing	nucleus					0		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		GGAGGAGGCAGAGGCCATCAA	0.587		NaN											0	0	0	0.008291	0	8	105									
PPFIA3	8541	broad.mit.edu	37	19	49643260	49643260	+	Silent	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:49643260G>A	uc002pmr.2	+	18	2615	c.2283G>A	c.(2281-2283)AAG>AAA	p.K761K	PPFIA3_uc010yai.1_RNA|PPFIA3_uc010yaj.1_RNA|PPFIA3_uc002pms.2_Silent_p.K629K|PPFIA3_uc002pmt.2_5'Flank	NM_003660	NP_003651	O75145	LIPA3_HUMAN	PTPRF interacting protein alpha 3	761						cell surface|cytoplasm	protein binding			lung(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		CCAAGAAGAAGAGCATCAAGT	0.557		NaN											0	0	0	0.004482	0	8	161									
DKKL1	27120	broad.mit.edu	37	19	49867919	49867919	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:49867919G>A	uc002pnk.2	+	2	305	c.91G>A	c.(91-93)GCT>ACT	p.A31T	TEAD2_uc002pni.2_5'Flank|TEAD2_uc002pnj.2_5'Flank|TEAD2_uc010yao.1_5'Flank|TEAD2_uc010emw.2_5'Flank	NM_014419	NP_055234	Q9UK85	DKKL1_HUMAN	dickkopf-like 1 precursor	31					anatomical structure morphogenesis	extracellular space	protein binding|signal transducer activity				0		all_lung(116;1.66e-06)|Lung NSC(112;5.89e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0456)		CTCCGCTGCAGCTCCTATCCA	0.622		NaN											0	0	0	0.008291	0	8	89									
VRK3	51231	broad.mit.edu	37	19	50510925	50510925	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:50510925C>T	uc002prg.2	-	5	546	c.448G>A	c.(448-450)GAA>AAA	p.E150K	VRK3_uc002prh.1_Missense_Mutation_p.E150K|VRK3_uc002pri.1_Missense_Mutation_p.E100K|VRK3_uc010ens.2_Missense_Mutation_p.E150K|VRK3_uc010ybl.1_Missense_Mutation_p.E100K|VRK3_uc010ybm.1_5'UTR|VRK3_uc002prj.1_Missense_Mutation_p.E100K|VRK3_uc002prk.1_Missense_Mutation_p.E150K|VRK3_uc010ent.1_5'UTR|VRK3_uc002prl.2_Missense_Mutation_p.E150K|VRK3_uc010ybn.1_Missense_Mutation_p.E150K	NM_016440	NP_057524	Q8IV63	VRK3_HUMAN	vaccinia related kinase 3 isoform 1	150						nucleus	ATP binding|protein kinase activity			stomach(1)|skin(1)	2		all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00166)|OV - Ovarian serous cystadenocarcinoma(262;0.00652)		GGCAAAGCTTCAAGTGAGGTG	0.582		NaN											0	0	0	0.00308	0	7	152									
C19orf41	126123	broad.mit.edu	37	19	50666221	50666221	+	Silent	SNP	C	C	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:50666221C>A	uc002prp.1	-	1	318	c.231G>T	c.(229-231)GTG>GTT	p.V77V		NM_152358	NP_689571	Q6UXV1	IZUM2_HUMAN	hypothetical protein LOC126123 precursor	77	Extracellular (Potential).					integral to membrane					0		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00364)|OV - Ovarian serous cystadenocarcinoma(262;0.0052)		AACACGCACCCACTTTCCCCA	0.682		NaN											1	0	0.000157383	0.00308	0.000163955	5	69									
ZNF347	84671	broad.mit.edu	37	19	53644299	53644299	+	Silent	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:53644299C>T	uc002qbb.1	-	5	1851	c.1782G>A	c.(1780-1782)GAG>GAA	p.E594E	ZNF347_uc010eql.1_Silent_p.E595E|ZNF347_uc002qbc.1_Silent_p.E595E	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	594					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)		TATAAGGTTTCTCTCCAGTAT	0.388		NaN											0	0	0	0.010504	0	17	151									
PRKCG	5582	broad.mit.edu	37	19	54410095	54410095	+	Missense_Mutation	SNP	C	C	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:54410095C>A	uc002qcq.1	+	18	2322	c.2040C>A	c.(2038-2040)TTC>TTA	p.F680L	PRKCG_uc010yeg.1_Missense_Mutation_p.F680L|PRKCG_uc010yeh.1_Missense_Mutation_p.F531L	NM_002739	NP_002730	P05129	KPCG_HUMAN	protein kinase C, gamma	680	AGC-kinase C-terminal.				activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			lung(4)|ovary(2)|pancreas(2)|large_intestine(1)	9	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		ACCCCGACTTCGTGCACCCGG	0.687		NaN									OREG0025667	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	2.80697e-09	0.000978	3.05159e-09	10	139									
ZNF582	147948	broad.mit.edu	37	19	56896256	56896256	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:56896256C>G	uc002qmz.1	-	5	689	c.530G>C	c.(529-531)AGA>ACA	p.R177T	ZNF582_uc002qmy.2_Missense_Mutation_p.R208T	NM_144690	NP_653291	Q96NG8	ZN582_HUMAN	zinc finger protein 582	177	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|large_intestine(1)	4		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0547)		GAAGTCTTTTCTACATTTATT	0.328		NaN											0	0	0	0.004672	0	3	41									
SLC27A5	10998	broad.mit.edu	37	19	59022230	59022230	+	Silent	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:59022230G>A	uc002qtc.2	-	2	866	c.756C>T	c.(754-756)CTC>CTT	p.L252L		NM_012254	NP_036386	Q9Y2P5	S27A5_HUMAN	solute carrier family 27 (fatty acid	252	Cytoplasmic (Probable).				bile acid and bile salt transport|bile acid biosynthetic process|very long-chain fatty acid metabolic process	endoplasmic reticulum membrane|integral to membrane	ATP binding|cholate-CoA ligase activity|long-chain fatty acid-CoA ligase activity				0		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.181)		AGGTATGGCTGAGGTAGAAGC	0.632		NaN											0	0	0	0.004672	0	3	37									
UBXN2A	165324	broad.mit.edu	37	2	24194153	24194153	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:24194153G>A	uc010exy.2	+	4	517	c.49G>A	c.(49-51)GAA>AAA	p.E17K	UBXN2A_uc002rem.2_RNA|UBXN2A_uc002ren.2_Missense_Mutation_p.E17K|UBXN2A_uc010ykj.1_Missense_Mutation_p.E17K	NM_181713	NP_859064	P68543	UBX2A_HUMAN	UBX domain containing 4	17											0						TAGGGTTTGTGAAACAGGATC	0.308		NaN											0	0	0	0.004482	0	7	100									
MAPRE3	22924	broad.mit.edu	37	2	27248831	27248831	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:27248831C>G	uc002rhw.2	+	6	861	c.708C>G	c.(706-708)ATC>ATG	p.I236M	MAPRE3_uc002rhx.2_Missense_Mutation_p.I221M	NM_012326	NP_036458	Q9UPY8	MARE3_HUMAN	microtubule-associated protein, RP/EB family,	236	APC-binding.|EB1 C-terminal.|DCTN1-binding.				cell division|mitosis|positive regulation of transcription, DNA-dependent	cytoplasm|cytoplasmic microtubule|microtubule|midbody|perinuclear region of cytoplasm	microtubule binding|protein binding|small GTPase regulator activity			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCGAGCTCATCTGCCAGGAGC	0.537		NaN											0	0	0	0.003163	0	12	90									
C2orf16	84226	broad.mit.edu	37	2	27805353	27805353	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:27805353C>T	uc002rkz.3	+	1	5965	c.5914C>T	c.(5914-5916)CCC>TCC	p.P1972S	ZNF512_uc010ylv.1_5'Flank|ZNF512_uc010ylw.1_5'Flank|ZNF512_uc002rlb.2_5'Flank|ZNF512_uc010ylx.1_5'Flank|ZNF512_uc002rlc.2_5'Flank|ZNF512_uc002rla.2_5'Flank|ZNF512_uc010yly.1_5'Flank|ZNF512_uc010ylz.1_5'Flank	NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	1972										large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					ACATAAAAATCCCAAAGCAGG	0.507		NaN											0	0	0	0.003954	0	19	188									
CCDC121	79635	broad.mit.edu	37	2	27850025	27850025	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:27850025C>G	uc002rle.2	-	2	823	c.642G>C	c.(640-642)CAG>CAC	p.Q214H	ZNF512_uc010yly.1_Intron|CCDC121_uc010eze.2_Missense_Mutation_p.Q378H|CCDC121_uc002rld.2_Missense_Mutation_p.Q376H|GPN1_uc010ezf.2_5'Flank|GPN1_uc010yma.1_5'Flank|GPN1_uc010ymb.1_5'Flank|GPN1_uc010ymc.1_5'Flank|GPN1_uc010ymd.1_5'Flank|GPN1_uc010yme.1_5'Flank|GPN1_uc010ezg.1_5'Flank	NM_024584	NP_078860	Q6ZUS5	CC121_HUMAN	coiled-coil domain containing 121 isoform 3	214	Potential.										0	Acute lymphoblastic leukemia(172;0.155)					CCGTTAGTTTCTGGGCTTGCT	0.478		NaN											0	0	0	0.004482	0	9	38									
SLC4A1AP	22950	broad.mit.edu	37	2	27900720	27900720	+	Silent	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:27900720G>A	uc002rlk.3	+	8	1974	c.1692G>A	c.(1690-1692)CTG>CTA	p.L564L		NM_018158	NP_060628	Q9BWU0	NADAP_HUMAN	solute carrier family 4 (anion exchanger),	564						cytoplasm|nucleus	double-stranded RNA binding|protein binding				0	Acute lymphoblastic leukemia(172;0.155)					CTTTTGAACTGAGGAAAGAAC	0.358		NaN											0	0	0	0.000978	0	10	68									
NLRC4	58484	broad.mit.edu	37	2	32475775	32475775	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:32475775G>C	uc002roi.2	-	4	1404	c.1158C>G	c.(1156-1158)TTC>TTG	p.F386L	NLRC4_uc002roj.1_Missense_Mutation_p.F386L|NLRC4_uc010ezt.1_Intron	NM_021209	NP_067032	Q9NPP4	NLRC4_HUMAN	caspase recruitment domain protein 12	386	NACHT.				activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			ovary(3)|large_intestine(1)|lung(1)|skin(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					GGCTCCGAATGAAGTCACTTG	0.468		NaN											0	0	0	0.008291	0	9	56									
BIRC6	57448	broad.mit.edu	37	2	32668572	32668572	+	Missense_Mutation	SNP	G	G	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:32668572G>T	uc010ezu.2	+	20	4386	c.4252G>T	c.(4252-4254)GAC>TAC	p.D1418Y		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	1418					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					TGGCAAATGTGACCCATGTCA	0.333		NaN											1	0	0.004672	0.004672	0.00477731	3	19									
BIRC6	57448	broad.mit.edu	37	2	32670646	32670646	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:32670646G>A	uc010ezu.2	+	21	4528	c.4394G>A	c.(4393-4395)GGA>GAA	p.G1465E		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	1465					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					GATCTGGCTGGATGCAGTACA	0.378		NaN											0	0	0	0.00499	0	13	39									
BIRC6	57448	broad.mit.edu	37	2	32673888	32673888	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:32673888G>A	uc010ezu.2	+	22	4644	c.4510G>A	c.(4510-4512)GAT>AAT	p.D1504N		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	1504					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					CTCACCATTTGATCCAGTCCT	0.313		NaN											0	0	0	0.006122	0	14	54									
ATL2	64225	broad.mit.edu	37	2	38570616	38570616	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:38570616C>G	uc002rqq.2	-	2	187	c.157G>C	c.(157-159)GAG>CAG	p.E53Q	ATL2_uc010ynm.1_Missense_Mutation_p.E35Q|ATL2_uc010ynn.1_Missense_Mutation_p.E35Q|ATL2_uc010yno.1_Intron|ATL2_uc002rqs.2_Missense_Mutation_p.E53Q|ATL2_uc002rqr.2_Intron	NM_001135673	NP_001129145	Q8NHH9	ATLA2_HUMAN	atlastin GTPase 2 isoform 2	53	Cytoplasmic.				endoplasmic reticulum organization|Golgi organization|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	GTP binding|GTPase activity|identical protein binding			ovary(1)|kidney(1)|skin(1)	3						TTCATAACCTCATCAGAATTT	0.338		NaN											0	0	0	0.006214	0	7	65									
NRXN1	9378	broad.mit.edu	37	2	50850623	50850623	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:50850623C>T	uc010fbq.2	-	6	2539	c.1062G>A	c.(1060-1062)ATG>ATA	p.M354I	NRXN1_uc002rxb.3_Missense_Mutation_p.M1I|NRXN1_uc002rxe.3_Missense_Mutation_p.M321I|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CAGTGTGAAGCATCAGTCCAT	0.433		NaN											0	0	0	0.00632	0	22	181									
GPR75	10936	broad.mit.edu	37	2	54081274	54081274	+	Missense_Mutation	SNP	T	T	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:54081274T>C	uc002rxo.3	-	2	891	c.620A>G	c.(619-621)TAT>TGT	p.Y207C	ASB3_uc002rxi.3_Intron	NM_006794	NP_006785	O95800	GPR75_HUMAN	G protein-coupled receptor 75	207	Helical; Name=5; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|skin(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			GTCGACCACATAGAGAGACAA	0.507		NaN											0	0	0	0.00308	0	7	117									
GPR75	10936	broad.mit.edu	37	2	54081280	54081280	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:54081280G>C	uc002rxo.3	-	2	885	c.614C>G	c.(613-615)TCT>TGT	p.S205C	ASB3_uc002rxi.3_Intron	NM_006794	NP_006785	O95800	GPR75_HUMAN	G protein-coupled receptor 75	205	Extracellular (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|skin(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			CACATAGAGAGACAAAATGGC	0.493		NaN											0	0	0	0.004482	0	8	114									
SERTAD2	9792	broad.mit.edu	37	2	64863402	64863402	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:64863402C>T	uc002sde.1	-	2	901	c.604G>A	c.(604-606)GAG>AAG	p.E202K		NM_014755	NP_055570	Q14140	SRTD2_HUMAN	SERTA domain containing 2	202					negative regulation of cell growth|transcription, DNA-dependent	cytoplasm|nucleus					0						GTGCCAGCCTCGCTGGAGGTC	0.567		NaN											0	0	0	0.005443	0	24	77									
C2orf68	388969	broad.mit.edu	37	2	85836116	85836116	+	Silent	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:85836116G>C	uc002sqc.2	-	4	525	c.453C>G	c.(451-453)CTC>CTG	p.L151L	USP39_uc002sqb.2_Intron	NM_001013649	NP_001013671	Q2NKX9	CB068_HUMAN	hypothetical protein LOC388969	151										central_nervous_system(1)	1						TACGCAACTTGAGGGCTTCTC	0.552		NaN											0	0	0	0.006214	0	7	115									
TEKT4	150483	broad.mit.edu	37	2	95537570	95537570	+	Silent	SNP	C	C	T	rs66467545		TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:95537570C>T	uc002stw.1	+	1	339	c.246C>T	c.(244-246)CGC>CGT	p.R82R	uc002stv.1_Intron|TEKT4_uc010fhr.1_RNA	NM_144705	NP_653306	Q8WW24	TEKT4_HUMAN	tektin 4	82					cell projection organization|microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(1)|breast(1)|skin(1)	3						TGGCGCAGCGCACGCAGCAAG	0.692		NaN											0	0	0	0.001984	0	4	24									
C2orf55	343990	broad.mit.edu	37	2	99413948	99413948	+	Silent	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:99413948C>T	uc002szf.1	-	8	2763	c.2469G>A	c.(2467-2469)GCG>GCA	p.A823A		NM_207362	NP_997245	Q6NV74	CB055_HUMAN	hypothetical protein LOC343990	823	Pro-rich.										0						TCCAGGGTGGCGCAGGCTGCC	0.587		NaN											0	0	0	0.004007	0	12	101									
NEB	4703	broad.mit.edu	37	2	152553184	152553184	+	Silent	SNP	T	T	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:152553184T>C	uc010fnx.2	-	17	1727	c.1536A>G	c.(1534-1536)CTA>CTG	p.L512L	NEB_uc010fny.1_Silent_p.L66L	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	512	Nebulin 12.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		CTTGGGCTTGTAGCAGAACAG	0.403		NaN											0	0	0	0.001168	0	5	59									
TTN	7273	broad.mit.edu	37	2	179482573	179482573	+	Silent	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:179482573G>A	uc010zfg.1	-	202	40025	c.39801C>T	c.(39799-39801)GCC>GCT	p.A13267A	TTN_uc010zfh.1_Silent_p.A6962A|TTN_uc010zfi.1_Silent_p.A6895A|TTN_uc010zfj.1_Silent_p.A6770A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	14194							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCGATTTTGGGCTCTCACTC	0.463		NaN											0	0	0	0.004482	0	9	96									
TTN	7273	broad.mit.edu	37	2	179497319	179497319	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:179497319C>G	uc010zfg.1	-	184	35934	c.35710G>C	c.(35710-35712)GAA>CAA	p.E11904Q	TTN_uc010zfh.1_Missense_Mutation_p.E5599Q|TTN_uc010zfi.1_Missense_Mutation_p.E5532Q|TTN_uc010zfj.1_Missense_Mutation_p.E5407Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12831							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTTCATCTTCAAAAGCAGCT	0.388		NaN											0	0	0	0.001855	0	14	113									
TTN	7273	broad.mit.edu	37	2	179575936	179575936	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:179575936C>G	uc010zfg.1	-	94	24519	c.24295G>C	c.(24295-24297)GAC>CAC	p.D8099H	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.D4760H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	9026							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGGGCTGTCTTTCAATGGC	0.423		NaN											0	0	0	0.00333	0	17	227									
TTN	7273	broad.mit.edu	37	2	179577067	179577067	+	Silent	SNP	G	G	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:179577067G>T	uc010zfg.1	-	92	24074	c.23850C>A	c.(23848-23850)TCC>TCA	p.S7950S	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.S4611S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8877							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTGCTGAACAGGAATCTTTTC	0.388		NaN											1	0	4.47668e-21	0.003954	4.9752e-21	20	243									
CCDC141	285025	broad.mit.edu	37	2	179720159	179720159	+	Missense_Mutation	SNP	T	T	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:179720159T>A	uc002unf.1	-	9	1307	c.1250A>T	c.(1249-1251)AAA>ATA	p.K417I		NM_173648	NP_775919	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	417							protein binding			ovary(7)|pancreas(2)|skin(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			ATCCACATGTTTTTGCAAATC	0.343		NaN											0	0	0	0.000602	0	4	73									
NEUROD1	4760	broad.mit.edu	37	2	182543034	182543034	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:182543034G>A	uc002uof.2	-	2	790	c.554C>T	c.(553-555)GCG>GTG	p.A185V	CERKL_uc002uod.1_Intron	NM_002500	NP_002491	Q13562	NDF1_HUMAN	neurogenic differentiation 1	185				A -> G (in Ref. 2; BAA11558 and 5; BAA87605).	amacrine cell differentiation|cerebellum development|dentate gyrus development|embryonic organ morphogenesis|enteroendocrine cell differentiation|glucose homeostasis|inner ear development|insulin secretion|negative regulation of apoptosis|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of intestinal epithelial structure maintenance|response to glucose stimulus	cytoplasm|nucleus	chromatin binding|E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.088)			CAGGCAGCCCGCAACCAGGTT	0.612		NaN											0	0	0	0.001168	0	6	59									
NUP35	129401	broad.mit.edu	37	2	183993048	183993048	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:183993048C>T	uc002upf.2	+	2	177	c.74C>T	c.(73-75)TCT>TTT	p.S25F	NUP35_uc010zfs.1_Missense_Mutation_p.S7F|NUP35_uc010zft.1_5'UTR|NUP35_uc002upg.2_RNA	NM_138285	NP_612142	Q8NFH5	NUP53_HUMAN	nucleoporin 35kDa	25					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	intermediate filament cytoskeleton|nuclear membrane|nuclear pore|plasma membrane					0						TCACCCACATCTCCAAAGCCA	0.418		NaN											0	0	0	0.000602	0	5	55									
WDR75	84128	broad.mit.edu	37	2	190333285	190333285	+	Silent	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:190333285G>A	uc002uql.1	+	15	1773	c.1713G>A	c.(1711-1713)CTG>CTA	p.L571L	WDR75_uc002uqm.1_Silent_p.L507L|WDR75_uc002uqn.1_Silent_p.L349L|WDR75_uc002uqo.1_Silent_p.L349L	NM_032168	NP_115544	Q8IWA0	WDR75_HUMAN	WD repeat domain 75	571	WD 9.					nucleolus				ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.00105)|Epithelial(96;0.0129)|all cancers(119;0.0456)			GGAATCTGCTGAGCTGTGCAT	0.388		NaN											0	0	0	0.008291	0	8	130									
FAM126B	285172	broad.mit.edu	37	2	201853102	201853102	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:201853102C>T	uc002uws.3	-	11	1062	c.874G>A	c.(874-876)GAT>AAT	p.D292N	FAM126B_uc002uwu.2_Missense_Mutation_p.D210N|FAM126B_uc002uwv.2_Missense_Mutation_p.D292N	NM_173822	NP_776183	Q8IXS8	F126B_HUMAN	hypothetical protein LOC285172	292						intracellular				ovary(1)	1						TGTGTAGAATCAGGAGCATCA	0.378		NaN											0	0	0	0.000978	0	9	89									
MAP2	4133	broad.mit.edu	37	2	210560669	210560669	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:210560669G>A	uc002vde.1	+	7	4023	c.3775G>A	c.(3775-3777)GAC>AAC	p.D1259N	MAP2_uc002vdc.1_Missense_Mutation_p.D1259N|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Missense_Mutation_p.D1255N	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	1259					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	TCAGATAACTGACCTGGGTGT	0.483		NaN											0	0	0	0.003163	0	14	84									
TMEM169	92691	broad.mit.edu	37	2	216965210	216965210	+	Nonsense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:216965210C>G	uc010zjr.1	+	4	1165	c.839C>G	c.(838-840)TCA>TGA	p.S280*	TMEM169_uc010zjs.1_Nonsense_Mutation_p.S280*|TMEM169_uc002vfw.2_Nonsense_Mutation_p.S280*|TMEM169_uc002vfv.3_Nonsense_Mutation_p.S280*	NM_001142310	NP_001135782	Q96HH4	TM169_HUMAN	transmembrane protein 169	280	Extracellular (Potential).					integral to membrane				ovary(1)	1		Renal(323;0.0651)		Epithelial(149;6.44e-06)|all cancers(144;0.000398)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GACAATATCTCAAGCACTCTC	0.512		NaN											0	0	0	0.00308	0	7	84									
IHH	3549	broad.mit.edu	37	2	219925066	219925066	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:219925066G>A	uc002vjo.1	-	1	124	c.124C>T	c.(124-126)CGC>TGC	p.R42C	hsa-mir-3131|MI0014151_5'Flank	NM_002181	NP_002172	Q14623	IHH_HUMAN	Indian hedgehog homolog precursor	42					cell-cell signaling|intein-mediated protein splicing|proteolysis	extracellular space|plasma membrane	cholesterol binding|patched binding|peptidase activity			breast(1)	1		Renal(207;0.0915)		Epithelial(149;1.13e-06)|all cancers(144;0.000188)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ACGAGTTTGCGTGGCGGTCGC	0.692		NaN											0	0	0	0.004672	0	3	47									
ABCB6	10058	broad.mit.edu	37	2	220077977	220077977	+	Silent	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:220077977G>A	uc002vkc.1	-	12	2068	c.1791C>T	c.(1789-1791)TTC>TTT	p.F597F	ABCB6_uc010fwe.1_Silent_p.F551F	NM_005689	NP_005680	Q9NP58	ABCB6_HUMAN	ATP-binding cassette, sub-family B, member 6	597	ABC transporter.				cadmium ion transmembrane transport|cellular iron ion homeostasis|detoxification of cadmium ion|porphyrin biosynthetic process	ATP-binding cassette (ABC) transporter complex|Golgi apparatus|integral to mitochondrial outer membrane|plasma membrane|vacuolar membrane	ATP binding|efflux transmembrane transporter activity|heme binding|heme-transporting ATPase activity			breast(1)|central_nervous_system(1)	2		Renal(207;0.0474)		Epithelial(149;1.22e-06)|all cancers(144;0.000201)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CGGCATAGCTGAAGTGCACGT	0.537		NaN											0	0	0	0.001984	0	6	45									
FASTKD5	60493	broad.mit.edu	37	20	3128235	3128235	+	Silent	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr20:3128235G>C	uc002whz.2	-	2	1793	c.1482C>G	c.(1480-1482)CTC>CTG	p.L494L	uc002whv.1_Intron|UBOX5_uc002whw.2_Intron|UBOX5_uc002whx.2_Intron|UBOX5_uc002why.1_Intron	NM_021826	NP_068598	Q7L8L6	FAKD5_HUMAN	FAST kinase domains 5	494					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity				0						ACCCTGGACTGAGAGCGAAAT	0.473		NaN											0	0	0	0.001168	0	6	74									
ATRN	8455	broad.mit.edu	37	20	3562848	3562848	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr20:3562848G>A	uc002wim.2	+	16	2701	c.2611G>A	c.(2611-2613)GAT>AAT	p.D871N	ATRN_uc002wil.2_Missense_Mutation_p.D871N	NM_139321	NP_647537	O75882	ATRN_HUMAN	attractin isoform 1	871	Extracellular (Potential).|C-type lectin.				inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			ovary(1)|breast(1)	2						GTGCTGGGAAGATATGTCCCC	0.468		NaN											0	0	0	0.00245	0	12	94									
ATRN	8455	broad.mit.edu	37	20	3562949	3562949	+	Silent	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr20:3562949G>A	uc002wim.2	+	16	2802	c.2712G>A	c.(2710-2712)CTG>CTA	p.L904L	ATRN_uc002wil.2_Silent_p.L904L	NM_139321	NP_647537	O75882	ATRN_HUMAN	attractin isoform 1	904	Extracellular (Potential).|C-type lectin.				inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			ovary(1)|breast(1)	2						CTCGGGGACTGAAGGCTGCAA	0.453		NaN											0	0	0	0.006214	0	10	176									
ABHD12	26090	broad.mit.edu	37	20	25275652	25275652	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr20:25275652G>A	uc002wuq.2	-	13	1310	c.1172C>T	c.(1171-1173)CCA>CTA	p.P391L	ABHD12_uc002wur.2_Missense_Mutation_p.P390L|PYGB_uc002wup.2_Intron	NM_015600	NP_056415	Q8N2K0	ABD12_HUMAN	abhydrolase domain containing 12 isoform b	Error:Variant_position_missing_in_Q8N2K0_after_alignment						integral to membrane	acylglycerol lipase activity			skin(1)	1						GCTGGAACCTGGGCCCTGCTG	0.473		NaN									OREG0025844	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008291	0	9	211									
PIGU	128869	broad.mit.edu	37	20	33222438	33222438	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr20:33222438G>C	uc002xas.2	-	6	710	c.510C>G	c.(508-510)TTC>TTG	p.F170L	PIGU_uc010zul.1_Missense_Mutation_p.F170L|PIGU_uc002xat.2_Missense_Mutation_p.F150L|PIGU_uc010gev.1_RNA	NM_080476	NP_536724	Q9H490	PIGU_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	170	Helical; (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation|regulation of JAK-STAT cascade	GPI-anchor transamidase complex|plasma membrane					0						TAGTCAAAATGAAGAAAGCAA	0.403		NaN											0	0	0	0.008291	0	7	91									
NCOA6	23054	broad.mit.edu	37	20	33356291	33356291	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr20:33356291C>A	uc002xav.2	-	6	3061	c.490G>T	c.(490-492)GGA>TGA	p.G164*	NCOA6_uc002xaw.2_Nonsense_Mutation_p.G164*|NCOA6_uc010gew.1_Nonsense_Mutation_p.G164*	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	164	TBP/GTF2A-binding region.|NCOA1-binding region.|CREBBP-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						ATAGGAAATCCCGCCTCCATC	0.458		NaN											1	0	3.52763e-06	0.00499	3.7613e-06	14	125									
SRC	6714	broad.mit.edu	37	20	36022668	36022668	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr20:36022668G>A	uc002xgx.2	+	7	990	c.541G>A	c.(541-543)GAG>AAG	p.E181K	SRC_uc002xgy.2_Missense_Mutation_p.E181K	NM_005417	NP_005408	P12931	SRC_HUMAN	proto-oncogene tyrosine-protein kinase SRC	181	SH2.				axon guidance|bone resorption|cell junction assembly|cellular membrane organization|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular protein kinase cascade|leukocyte migration|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of integrin activation|Ras protein signal transduction|regulation of bone resorption|regulation of vascular permeability|response to interleukin-1|signal complex assembly|T cell costimulation	caveola|cytosol|mitochondrial inner membrane	ATP binding|heme binding|integrin binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|SH3/SH2 adaptor activity			large_intestine(10)|lung(1)|central_nervous_system(1)|endometrium(1)	13		Myeloproliferative disorder(115;0.00878)			Dasatinib(DB01254)	GCGAGAAAGTGAGACCACGAA	0.448		NaN											0	0	0	0.006214	0	8	85									
L3MBTL	26013	broad.mit.edu	37	20	42161536	42161536	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr20:42161536G>C	uc010zwh.1	+	12	1388	c.1342G>C	c.(1342-1344)GAC>CAC	p.D448H	L3MBTL_uc002xkl.2_Missense_Mutation_p.D380H|L3MBTL_uc002xkm.2_Missense_Mutation_p.D380H|L3MBTL_uc010ggl.2_Missense_Mutation_p.D380H|L3MBTL_uc002xkn.1_Missense_Mutation_p.D139H|L3MBTL_uc002xko.2_Missense_Mutation_p.D32H	NM_015478	NP_056293	Q9Y468	LMBL1_HUMAN	l(3)mbt-like isoform I	380	MBT 2.|Interaction with monomethylated and dimethylated peptides.				chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	identical protein binding|methylated histone residue binding|nucleosomal histone binding|SAM domain binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			GGTGCACTTTGACAACTGGGA	0.582		NaN											0	0	0	0.004482	0	9	93									
L3MBTL	26013	broad.mit.edu	37	20	42162962	42162962	+	Silent	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr20:42162962G>A	uc010zwh.1	+	15	1618	c.1572G>A	c.(1570-1572)GAG>GAA	p.E524E	L3MBTL_uc002xkl.2_Silent_p.E456E|L3MBTL_uc002xkm.2_Silent_p.E456E|L3MBTL_uc010ggl.2_Silent_p.E456E|L3MBTL_uc002xkn.1_Silent_p.E215E|L3MBTL_uc002xko.2_Silent_p.E108E	NM_015478	NP_056293	Q9Y468	LMBL1_HUMAN	l(3)mbt-like isoform I	456	MBT 3.				chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	identical protein binding|methylated histone residue binding|nucleosomal histone binding|SAM domain binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			TGAAGCTGGAGGCTGTGGACC	0.632		NaN											0	0	0	0.004482	0	6	101									
NCOA3	8202	broad.mit.edu	37	20	46255875	46255875	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr20:46255875G>A	uc002xtk.2	+	6	692	c.487G>A	c.(487-489)GAA>AAA	p.E163K	NCOA3_uc010ght.1_Missense_Mutation_p.E163K|NCOA3_uc002xtl.2_Missense_Mutation_p.E163K|NCOA3_uc002xtm.2_Missense_Mutation_p.E163K|NCOA3_uc002xtn.2_Missense_Mutation_p.E163K|NCOA3_uc010zyc.1_5'UTR	NM_181659	NP_858045	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3 isoform a	163	PAS.				androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			ovary(3)|lung(1)|skin(1)	5						TATCTTACATGAAGAAGACAG	0.313		NaN											0	0	0	0.001168	0	4	67									
NCOA3	8202	broad.mit.edu	37	20	46255881	46255881	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr20:46255881G>A	uc002xtk.2	+	6	698	c.493G>A	c.(493-495)GAC>AAC	p.D165N	NCOA3_uc010ght.1_Missense_Mutation_p.D165N|NCOA3_uc002xtl.2_Missense_Mutation_p.D165N|NCOA3_uc002xtm.2_Missense_Mutation_p.D165N|NCOA3_uc002xtn.2_Missense_Mutation_p.D165N|NCOA3_uc010zyc.1_5'UTR	NM_181659	NP_858045	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3 isoform a	165	PAS.				androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			ovary(3)|lung(1)|skin(1)	5						ACATGAAGAAGACAGAAAGGA	0.308		NaN											0	0	0	0.009096	0	4	63									
CSE1L	1434	broad.mit.edu	37	20	47706239	47706239	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr20:47706239G>A	uc002xty.2	+	19	2271	c.2137G>A	c.(2137-2139)GAA>AAA	p.E713K	CSE1L_uc010zyg.1_Missense_Mutation_p.E496K|CSE1L_uc010ghx.2_Missense_Mutation_p.E657K|CSE1L_uc010ghy.2_Missense_Mutation_p.E334K|CSE1L_uc010zyh.1_Missense_Mutation_p.E362K	NM_001316	NP_001307	P55060	XPO2_HUMAN	CSE1 chromosome segregation 1-like protein	713					apoptosis|cell proliferation|intracellular protein transport	cytoplasm|nucleus	importin-alpha export receptor activity			large_intestine(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000491)|Colorectal(8;0.198)			AGCATTCTTAGAACGCGGTTC	0.418		NaN											0	0	0	0.006214	0	7	108									
STAU1	6780	broad.mit.edu	37	20	47734330	47734330	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr20:47734330C>T	uc002xud.2	-	11	1904	c.1493G>A	c.(1492-1494)AGA>AAA	p.R498K	STAU1_uc002xua.2_Missense_Mutation_p.R417K|STAU1_uc002xub.2_Missense_Mutation_p.R423K|STAU1_uc002xuc.2_Missense_Mutation_p.R417K|STAU1_uc002xue.2_Missense_Mutation_p.R417K|STAU1_uc002xuf.2_Missense_Mutation_p.R423K|STAU1_uc002xug.2_Missense_Mutation_p.R498K	NM_017453	NP_059347	O95793	STAU1_HUMAN	staufen isoform b	498						microtubule associated complex|rough endoplasmic reticulum|stress granule	double-stranded RNA binding			ovary(4)|kidney(1)	5			BRCA - Breast invasive adenocarcinoma(12;0.000644)|Colorectal(8;0.198)			TCCCTGGACTCTGGAAAGATA	0.498		NaN											0	0	0	0.006214	0	9	68									
APCDD1L	164284	broad.mit.edu	37	20	57042196	57042196	+	Missense_Mutation	SNP	G	G	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr20:57042196G>T	uc002xze.1	-	3	893	c.707C>A	c.(706-708)CCC>CAC	p.P236H	APCDD1L_uc010zzp.1_Missense_Mutation_p.P247H	NM_153360	NP_699191	Q8NCL9	APCDL_HUMAN	adenomatosis polyposis coli down-regulated	236						integral to membrane				ovary(1)	1	Lung NSC(12;0.000856)|all_lung(29;0.0025)		BRCA - Breast invasive adenocarcinoma(13;5.6e-11)|Epithelial(14;1.67e-07)|all cancers(14;1.48e-06)			GTAGCCCGTGGGCCGGTAGTG	0.731		NaN											1	0	3.32936e-07	0.006122	3.5575e-07	14	81									
TIAM1	7074	broad.mit.edu	37	21	32617916	32617916	+	Missense_Mutation	SNP	G	G	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr21:32617916G>T	uc002yow.1	-	7	1944	c.1472C>A	c.(1471-1473)CCC>CAC	p.P491H	TIAM1_uc011adk.1_Missense_Mutation_p.P491H|TIAM1_uc011adl.1_Missense_Mutation_p.P491H|TIAM1_uc002yox.1_Missense_Mutation_p.P99H	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	491	PH 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						GGCGTGTTTGGGGATGCTGTT	0.552		NaN											1	0	4.096e-09	0.001168	4.44327e-09	5	56									
UMODL1	89766	broad.mit.edu	37	21	43496222	43496222	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr21:43496222G>A	uc002zaf.1	+	2	185	c.185G>A	c.(184-186)GGC>GAC	p.G62D	UMODL1_uc002zad.1_5'UTR|UMODL1_uc002zae.1_5'UTR|UMODL1_uc002zag.1_Missense_Mutation_p.G62D|uc002zah.1_RNA	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	62	Extracellular (Potential).|EMI.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						GTGTCCTGCGGCGGCTGGATC	0.607		NaN											0	0	0	0.001168	0	5	77									
ABCG1	9619	broad.mit.edu	37	21	43691217	43691217	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr21:43691217C>G	uc002zaq.2	+	3	430	c.324C>G	c.(322-324)TTC>TTG	p.F108L	ABCG1_uc002zan.2_Missense_Mutation_p.F110L|ABCG1_uc002zam.2_Missense_Mutation_p.F86L|ABCG1_uc002zao.2_Missense_Mutation_p.F105L|ABCG1_uc002zap.2_Missense_Mutation_p.F108L|ABCG1_uc002zar.2_Missense_Mutation_p.F119L|ABCG1_uc011aev.1_Missense_Mutation_p.F119L	NM_004915	NP_004906	P45844	ABCG1_HUMAN	ATP-binding cassette sub-family G member 1	108	Cytoplasmic (Potential).|ABC transporter.				amyloid precursor protein catabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|detection of hormone stimulus|high-density lipoprotein particle remodeling|intracellular cholesterol transport|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|positive regulation of cholesterol biosynthetic process|regulation of cholesterol esterification|regulation of transcription, DNA-dependent|response to lipid|reverse cholesterol transport	endoplasmic reticulum membrane|external side of plasma membrane|Golgi membrane|recycling endosome	ADP binding|ATP binding|cholesterol transporter activity|glycoprotein transporter activity|phospholipid transporter activity|protein heterodimerization activity|protein homodimerization activity|sterol-transporting ATPase activity|toxin transporter activity			ovary(2)|central_nervous_system(1)	3					Adenosine triphosphate(DB00171)	CCGGGAAGTTCAATAGTGGTG	0.473		NaN											0	0	0	0.003163	0	12	125									
CRYBB3	1417	broad.mit.edu	37	22	25599847	25599847	+	Silent	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr22:25599847C>G	uc003abo.1	+	4	384	c.312C>G	c.(310-312)CTC>CTG	p.L104L		NM_004076	NP_004067	P26998	CRBB3_HUMAN	crystallin, beta B3	104	Beta/gamma crystallin 'Greek key' 2.				visual perception		protein binding|structural constituent of eye lens				0						TTCTGTCCCTCCGGCCTCTGA	0.582		NaN											0	0	0	0.002836	0	27	260									
PLA2G3	50487	broad.mit.edu	37	22	31533774	31533774	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr22:31533774G>A	uc003aka.2	-	4	1117	c.988C>T	c.(988-990)CAG>TAG	p.Q330*		NM_015715	NP_056530	Q9NZ20	PA2G3_HUMAN	phospholipase A2, group III precursor	330					cilium morphogenesis|lipid catabolic process|phospholipid metabolic process	centriole|extracellular space|plasma membrane	calcium ion binding|calcium-dependent phospholipase A2 activity				0						ATAGGGTCCTGGAGGGCTGTG	0.627		NaN											0	0	0	0.003163	0	12	176									
MYH9	4627	broad.mit.edu	37	22	36712697	36712697	+	Silent	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr22:36712697C>T	uc003apg.2	-	12	1476	c.1245G>A	c.(1243-1245)GAG>GAA	p.E415E	MYH9_uc003aph.1_Silent_p.E279E	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	415	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						TGGCCAAGGCCTCGATGGCAA	0.478		NaN	T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				0	0	0	0.001168	0	5	59									
ADSL	158	broad.mit.edu	37	22	40755278	40755278	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr22:40755278C>G	uc003ayp.3	+	6	728	c.669C>G	c.(667-669)GAC>GAG	p.D223E	ADSL_uc003ays.3_Missense_Mutation_p.D223E|ADSL_uc003ayq.3_Missense_Mutation_p.D223E|ADSL_uc003ayr.3_5'UTR|ADSL_uc003ayt.3_Missense_Mutation_p.D208E|ADSL_uc010gyb.1_RNA	NM_000026	NP_000017	P30566	PUR8_HUMAN	adenylosuccinate lyase isoform a	223					AMP biosynthetic process|protein tetramerization|purine base metabolic process	cytosol	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity|N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity			ovary(1)	1						AGCAGCTTGACAAGATGGTGA	0.443		NaN											0	0	0	0.00499	0	13	186									
SCUBE1	80274	broad.mit.edu	37	22	43619192	43619192	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr22:43619192G>A	uc003bdt.1	-	11	1326	c.1238C>T	c.(1237-1239)ACC>ATC	p.T413I		NM_173050	NP_766638	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	413					adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	5		all_neural(38;0.0414)|Ovarian(80;0.07)				CCGGGGGGAGGTCTTGGCGCG	0.642		NaN											0	0	0	0.008871	0	15	205									
HRH1	3269	broad.mit.edu	37	3	11301168	11301168	+	Silent	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:11301168C>T	uc010hdr.2	+	2	787	c.445C>T	c.(445-447)CTG>TTG	p.L149L	HRH1_uc010hds.2_Silent_p.L149L|HRH1_uc010hdt.2_Silent_p.L149L|HRH1_uc003bwb.3_Silent_p.L149L	NM_001098213	NP_001091683	P35367	HRH1_HUMAN	histamine receptor H1	149	Helical; Name=4; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|inflammatory response	cytoplasm|integral to plasma membrane|nucleus	histamine receptor activity			large_intestine(1)|ovary(1)	2					Aceprometazine(DB01615)|Astemizole(DB00637)|Azatadine(DB00719)|Azelastine(DB00972)|Benzquinamide(DB00767)|Bepotastine(DB04890)|Bromodiphenhydramine(DB01237)|Brompheniramine(DB00835)|Buclizine(DB00354)|Carbinoxamine(DB00748)|Cetirizine(DB00341)|Chlophedianol(DB04837)|Chlorpheniramine(DB01114)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clemastine(DB00283)|Clozapine(DB00363)|Cyclizine(DB01176)|Cyproheptadine(DB00434)|Desipramine(DB01151)|Desloratadine(DB00967)|Dexbrompheniramine(DB00405)|Dimenhydrinate(DB00985)|Diphenhydramine(DB01075)|Diphenylpyraline(DB01146)|Doxepin(DB01142)|Doxylamine(DB00366)|Emedastine(DB01084)|Epinastine(DB00751)|Fexofenadine(DB00950)|Flunarizine(DB04841)|Histamine Phosphate(DB00667)|Hydroxyzine(DB00557)|Ketotifen(DB00920)|Levocabastine(DB01106)|Loratadine(DB00455)|Maprotiline(DB00934)|Meclizine(DB00737)|Mequitazine(DB01071)|Methdilazine(DB00902)|Methotrimeprazine(DB01403)|Mianserin(DB06148)|Mirtazapine(DB00370)|Nedocromil(DB00716)|Olanzapine(DB00334)|Olopatadine(DB00768)|Orphenadrine(DB01173)|Pemirolast(DB00885)|Phenindamine(DB01619)|Pheniramine(DB01620)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Terfenadine(DB00342)|Thiethylperazine(DB00372)|Trazodone(DB00656)|Trimeprazine(DB01246)|Tripelennamine(DB00792)|Triprolidine(DB00427)|Ziprasidone(DB00246)	GGCCACCATTCTGGGGGCCTG	0.542		NaN											0	0	0	0.001168	0	6	97									
NUP210	23225	broad.mit.edu	37	3	13401814	13401814	+	Missense_Mutation	SNP	G	G	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:13401814G>T	uc003bxv.1	-	15	2193	c.2110C>A	c.(2110-2112)CAG>AAG	p.Q704K	NUP210_uc003bxx.2_Missense_Mutation_p.Q376K	NM_024923	NP_079199	Q8TEM1	PO210_HUMAN	nucleoporin 210 precursor	704	Lumenal (Probable).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				ovary(3)|large_intestine(3)|skin(3)|pancreas(1)|liver(1)	11	all_neural(104;0.187)					CAGTGTTGCTGATAATTCCGG	0.567		NaN											1	0	1.96292e-10	0.010504	2.14802e-10	18	79									
ARPP21	10777	broad.mit.edu	37	3	35729240	35729240	+	Missense_Mutation	SNP	C	C	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:35729240C>A	uc003cgb.2	+	6	535	c.271C>A	c.(271-273)CAT>AAT	p.H91N	ARPP21_uc003cga.2_Missense_Mutation_p.H91N|ARPP21_uc011axy.1_Missense_Mutation_p.H91N|ARPP21_uc003cgf.2_5'Flank	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	91						cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3						GGAATCAATTCATTTACAGCT	0.338		NaN											1	0	1.15088e-07	0.004007	1.23503e-07	11	92									
TRANK1	9881	broad.mit.edu	37	3	36896768	36896768	+	Missense_Mutation	SNP	C	C	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:36896768C>A	uc003cgj.2	-	3	2965	c.2663G>T	c.(2662-2664)CGC>CTC	p.R888L		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	1438					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						GAACAGAGAGCGCAGATCGCT	0.542		NaN											1	0	9.95505e-16	0.002299	1.1039e-15	21	133									
VILL	50853	broad.mit.edu	37	3	38048129	38048129	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:38048129G>A	uc003chj.2	+	19	2681	c.2395G>A	c.(2395-2397)GAA>AAA	p.E799K	VILL_uc003chl.2_Missense_Mutation_p.E799K	NM_015873	NP_056957	O15195	VILL_HUMAN	villin-like protein	799	HP.				actin filament capping|cytoskeleton organization	actin cytoskeleton	actin binding|structural constituent of cytoskeleton				0				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		CCTGCGCCGGGAACAACTGAT	0.657		NaN											0	0	0	0.00278	0	21	74									
DLEC1	9940	broad.mit.edu	37	3	38163892	38163892	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:38163892C>G	uc003cho.1	+	37	5278	c.5257C>G	c.(5257-5259)CAC>GAC	p.H1753D	DLEC1_uc003chp.1_Silent_p.L1711L|DLEC1_uc010hgv.1_Missense_Mutation_p.H1756D|DLEC1_uc003chr.1_Missense_Mutation_p.H824D|DLEC1_uc003chs.1_Silent_p.L268L	NM_007335	NP_031361	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	1753					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		CATGTTGCCTCACCAGCCCTG	0.602		NaN											0	0	0	0.006214	0	7	121									
TRAK1	22906	broad.mit.edu	37	3	42226217	42226217	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:42226217C>A	uc003cky.2	+	4	620	c.404C>A	c.(403-405)TCG>TAG	p.S135*	TRAK1_uc011azh.1_Nonsense_Mutation_p.S135*|TRAK1_uc011azi.1_Nonsense_Mutation_p.S135*|TRAK1_uc003ckz.3_Nonsense_Mutation_p.S61*|TRAK1_uc011azj.1_Nonsense_Mutation_p.S61*|TRAK1_uc003cla.2_Nonsense_Mutation_p.S77*	NM_001042646	NP_001036111	Q9UPV9	TRAK1_HUMAN	OGT(O-Glc-NAc transferase)-interacting protein	135	Potential.|HAP1 N-terminal.				endosome to lysosome transport|protein O-linked glycosylation|protein targeting|regulation of transcription from RNA polymerase II promoter	early endosome|mitochondrion|nucleus				ovary(1)	1						ATCGGCCAGTCGTTGTTGAAG	0.507		NaN											1	0	1.36491e-13	0.001855	1.50684e-13	12	180									
TRAK1	22906	broad.mit.edu	37	3	42226284	42226284	+	Silent	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:42226284C>T	uc003cky.2	+	4	687	c.471C>T	c.(469-471)ATC>ATT	p.I157I	TRAK1_uc011azh.1_Silent_p.I157I|TRAK1_uc011azi.1_Silent_p.I157I|TRAK1_uc003ckz.3_Silent_p.I83I|TRAK1_uc011azj.1_Silent_p.I83I|TRAK1_uc003cla.2_Silent_p.I99I	NM_001042646	NP_001036111	Q9UPV9	TRAK1_HUMAN	OGT(O-Glc-NAc transferase)-interacting protein	157	Potential.|HAP1 N-terminal.				endosome to lysosome transport|protein O-linked glycosylation|protein targeting|regulation of transcription from RNA polymerase II promoter	early endosome|mitochondrion|nucleus				ovary(1)	1						TGGAACACATCAGGGAGGAGG	0.582		NaN											0	0	0	0.000978	0	10	165									
PTH1R	5745	broad.mit.edu	37	3	46942574	46942574	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:46942574G>A	uc003cqm.2	+	11	1251	c.1048G>A	c.(1048-1050)GGG>AGG	p.G350R	PTH1R_uc003cqn.2_Missense_Mutation_p.G350R	NM_000316	NP_000307	Q03431	PTH1R_HUMAN	parathyroid hormone receptor 1 precursor	350	Extracellular (Potential).					cytoplasm|integral to plasma membrane|nucleus	parathyroid hormone receptor activity|peptide hormone binding|protein self-association			breast(1)	1						GGCCAACACCGGGTAGGTCCA	0.627		NaN							Ollier_disease_/_Maffuci_syndrome				0	0	0	0.004672	0	3	15									
QARS	5859	broad.mit.edu	37	3	49137079	49137079	+	Missense_Mutation	SNP	G	G	A	rs141072684		TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:49137079G>A	uc003cvx.2	-	16	1395	c.1390C>T	c.(1390-1392)CGC>TGC	p.R464C	QARS_uc011bcc.1_5'Flank|QARS_uc011bcd.1_Missense_Mutation_p.R319C|QARS_uc003cvy.2_Missense_Mutation_p.R319C|QARS_uc011bce.1_Missense_Mutation_p.R453C	NM_005051	NP_005042	P47897	SYQ_HUMAN	glutaminyl-tRNA synthetase	464					glutaminyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|glutamine-tRNA ligase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)	L-Glutamine(DB00130)	TAGGAAGAGCGTCTGGGGTGG	0.572		NaN											0	0	0	0.00499	0	16	44									
ITIH3	3699	broad.mit.edu	37	3	52836749	52836749	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:52836749C>T	uc003dfv.2	+	13	1672	c.1636C>T	c.(1636-1638)CGG>TGG	p.R546W	ITIH3_uc011bek.1_Intron	NM_002217	NP_002208	Q06033	ITIH3_HUMAN	inter-alpha (globulin) inhibitor H3	546					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|liver(1)	3				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		CCTGCAGGAGCGGGACTACAT	0.602		NaN											0	0	0	0.006214	0	8	97									
SLMAP	7871	broad.mit.edu	37	3	57908654	57908654	+	Silent	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:57908654G>A	uc003dje.1	+	21	2503	c.2298G>A	c.(2296-2298)TTG>TTA	p.L766L	SLMAP_uc003djd.1_Silent_p.L749L|SLMAP_uc003djf.1_Silent_p.L728L|SLMAP_uc003djg.1_Silent_p.L360L|SLMAP_uc011bez.1_Silent_p.L234L|SLMAP_uc011bfa.1_Silent_p.L300L|SLMAP_uc003dji.1_Silent_p.L300L|SLMAP_uc011bfb.1_Silent_p.L300L|SLMAP_uc011bfc.1_Silent_p.L259L	NM_007159	NP_009090	Q14BN4	SLMAP_HUMAN	sarcolemma associated protein	766	Cytoplasmic (Potential).|Potential.				muscle contraction|protein folding	integral to plasma membrane|microtubule organizing center|prefoldin complex|sarcolemma|smooth endoplasmic reticulum	unfolded protein binding				0				BRCA - Breast invasive adenocarcinoma(55;0.000271)|KIRC - Kidney renal clear cell carcinoma(284;0.0602)|Kidney(284;0.0754)|OV - Ovarian serous cystadenocarcinoma(275;0.182)		AACTGAAGTTGAAGTTTGAAA	0.368		NaN											0	0	0	0.009096	0	4	77									
CNTN3	5067	broad.mit.edu	37	3	74535680	74535680	+	Silent	SNP	T	T	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:74535680T>C	uc003dpm.1	-	3	365	c.285A>G	c.(283-285)ACA>ACG	p.T95T		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	95	Ig-like C2-type 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		GGTAAGTTCCTGTATCCCAAT	0.373		NaN											0	0	0	0.001984	0	5	88									
GBE1	2632	broad.mit.edu	37	3	81586104	81586104	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:81586104C>T	uc003dqg.2	-	14	2044	c.1761G>A	c.(1759-1761)ATG>ATA	p.M587I	GBE1_uc011bgm.1_Missense_Mutation_p.M546I	NM_000158	NP_000149	Q04446	GLGB_HUMAN	glucan (1,4-alpha-), branching enzyme 1	587					glucose metabolic process|glycogen biosynthetic process	cytosol	1,4-alpha-glucan branching enzyme activity|cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(3)	3		Lung NSC(201;0.0117)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0654)|Epithelial(33;0.00305)|LUSC - Lung squamous cell carcinoma(29;0.00646)|BRCA - Breast invasive adenocarcinoma(55;0.00813)|Lung(72;0.0129)|KIRC - Kidney renal clear cell carcinoma(39;0.212)|Kidney(39;0.247)		CCAATCTATTCATATCCCTGT	0.413		NaN							Glycogen_Storage_Disease_type_IV				0	0	0	0.001168	0	5	88									
OR5H2	79310	broad.mit.edu	37	3	98002337	98002337	+	Silent	SNP	A	A	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:98002337A>G	uc003dsj.1	+	1	606	c.606A>G	c.(604-606)CTA>CTG	p.L202L		NM_001005482	NP_001005482	Q8NGV7	OR5H2_HUMAN	olfactory receptor, family 5, subfamily H,	202	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3						TTAATTTTCTAATGGTTTTTA	0.308		NaN											0	0	0	0.003163	0	13	42									
OR5K2	402135	broad.mit.edu	37	3	98217064	98217064	+	Silent	SNP	T	T	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:98217064T>C	uc011bgx.1	+	1	540	c.540T>C	c.(538-540)GAT>GAC	p.D180D		NM_001004737	NP_001004737	Q8NHB8	OR5K2_HUMAN	olfactory receptor, family 5, subfamily K,	180	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2						TTTACTGTGATACTCTTCCCT	0.403		NaN											0	0	0	0.004007	0	13	272									
CLDND1	56650	broad.mit.edu	37	3	98235645	98235645	+	Missense_Mutation	SNP	T	T	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:98235645T>C	uc003dsp.2	-	5	1500	c.620A>G	c.(619-621)AAT>AGT	p.N207S	CLDND1_uc003dso.2_Intron|CLDND1_uc003dsq.2_Missense_Mutation_p.N207S|CLDND1_uc003dss.2_Missense_Mutation_p.N207S|CLDND1_uc003dsr.2_Missense_Mutation_p.N112S|CLDND1_uc003dst.2_Missense_Mutation_p.N230S|CLDND1_uc003dsu.2_Missense_Mutation_p.N207S|CLDND1_uc003dsv.2_Missense_Mutation_p.N207S	NM_019895	NP_063948	Q9NY35	CLDN1_HUMAN	claudin domain containing 1 protein isoform a	207						integral to membrane				ovary(1)	1						ACCGGATACATTGTCAGGGAG	0.478		NaN											0	0	0	0.00499	0	14	69									
RG9MTD1	54931	broad.mit.edu	37	3	101283942	101283942	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:101283942G>C	uc003duz.2	+	2	465	c.317G>C	c.(316-318)AGA>ACA	p.R106T		NM_017819	NP_060289	Q7L0Y3	MRRP1_HUMAN	RNA (guanine-9-) methyltransferase domain	106					tRNA processing	mitochondrion	methyltransferase activity|protein binding			ovary(1)	1						TTGCTTGGCAGAGAAGTACCA	0.373		NaN											0	0	0	0.001368	0	9	116									
KIAA1524	57650	broad.mit.edu	37	3	108273331	108273331	+	Missense_Mutation	SNP	T	T	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:108273331T>C	uc003dxb.3	-	18	2485	c.2216A>G	c.(2215-2217)GAA>GGA	p.E739G		NM_020890	NP_065941	Q8TCG1	CIP2A_HUMAN	p90 autoantigen	739	Potential.					cytoplasm|integral to membrane	protein binding			ovary(2)|central_nervous_system(1)	3						TTCAGTACTTTCATTTCTGAA	0.323		NaN											0	0	0	0.004672	0	2	8									
SLC35A5	55032	broad.mit.edu	37	3	112299549	112299549	+	Silent	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:112299549C>T	uc003dze.2	+	6	830	c.585C>T	c.(583-585)TTC>TTT	p.F195F		NM_017945	NP_060415	Q9BS91	S35A5_HUMAN	solute carrier family 35, member A5	195						Golgi membrane|integral to membrane	nucleotide-sugar transmembrane transporter activity|sugar:hydrogen symporter activity			ovary(1)	1						GCCTTCTTTTCAGAAGTGAGT	0.463		NaN											0	0	0	0.000978	0	10	70									
ZXDC	79364	broad.mit.edu	37	3	126157291	126157291	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:126157291G>A	uc003eiv.2	-	10	2558	c.2504C>T	c.(2503-2505)TCA>TTA	p.S835L	ZXDC_uc010hsh.2_RNA	NM_025112	NP_079388	Q2QGD7	ZXDC_HUMAN	ZXD family zinc finger C isoform 1	835	Interaction with CIITA.				positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|LRR domain binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.155)		GCCTCCAGATGAGGGGAGCAC	0.627		NaN											0	0	0	0.000602	0	4	33									
NPHP3	27031	broad.mit.edu	37	3	132418250	132418250	+	Silent	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:132418250C>T	uc003epe.1	-	13	2009	c.1932G>A	c.(1930-1932)GTG>GTA	p.V644V	NPHP3_uc003epd.1_5'UTR	NM_153240	NP_694972	Q7Z494	NPHP3_HUMAN	nephrocystin 3	644					maintenance of organ identity|negative regulation of canonical Wnt receptor signaling pathway|photoreceptor cell maintenance|regulation of Wnt receptor signaling pathway, planar cell polarity pathway|Wnt receptor signaling pathway	cilium	protein binding			ovary(1)	1						CTCTTACATTCACTGGCAGTG	0.323		NaN											0	0	0	0.00308	0	6	58									
SLCO2A1	6578	broad.mit.edu	37	3	133661560	133661560	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:133661560C>T	uc003eqa.3	-	11	1788	c.1514G>A	c.(1513-1515)GGA>GAA	p.G505E	SLCO2A1_uc003eqb.3_Missense_Mutation_p.G429E|SLCO2A1_uc011blv.1_Missense_Mutation_p.G324E	NM_005630	NP_005621	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family,	505	Extracellular (Potential).				sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			central_nervous_system(1)	1						AGGGCACGATCCTGTCTTTGC	0.532		NaN											0	0	0	0.008361	0	22	122									
TIPARP	25976	broad.mit.edu	37	3	156395594	156395594	+	Silent	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:156395594G>A	uc003fav.2	+	2	356	c.108G>A	c.(106-108)TTG>TTA	p.L36L	LOC100287227_uc011boq.1_5'Flank|TIPARP_uc003faw.2_Silent_p.L36L	NM_015508	NP_056323	Q7Z3E1	PARPT_HUMAN	TCDD-inducible poly(ADP-ribose) polymerase	36							NAD+ ADP-ribosyltransferase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)|breast(1)	2			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			TCACTCCATTGAAGACTTGTT	0.448		NaN											0	0	0	0.006214	0	8	76									
PIK3CA	5290	broad.mit.edu	37	3	178927486	178927486	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:178927486G>A	uc003fjk.2	+	7	1406	c.1249G>A	c.(1249-1251)GAG>AAG	p.E417K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	417	C2 PI3K-type.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			GGGTGCTAAAGAGGTAAAGTA	0.343		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			0	0	0	0.003163	0	14	91									
MFN1	55669	broad.mit.edu	37	3	179080190	179080190	+	Silent	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:179080190G>A	uc003fjs.2	+	5	582	c.456G>A	c.(454-456)TTG>TTA	p.L152L	MFN1_uc010hxb.2_RNA|MFN1_uc003fjt.2_Silent_p.L180L|MFN1_uc010hxc.2_Silent_p.L5L	NM_033540	NP_284941	Q8IWA4	MFN1_HUMAN	mitofusin 1	152	Cytoplasmic (Potential).				mitochondrial fusion	integral to membrane|mitochondrial outer membrane	GTP binding|GTPase activity			ovary(2)|large_intestine(1)	3	all_cancers(143;1.67e-16)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.00225)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			ACAAAGATTTGAAAGCTGGCT	0.383		NaN											0	0	0	0.006214	0	7	94									
MCCC1	56922	broad.mit.edu	37	3	182769981	182769981	+	Silent	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:182769981G>A	uc003fle.2	-	9	1058	c.921C>T	c.(919-921)GTC>GTT	p.V307V	MCCC1_uc010hxi.2_RNA|MCCC1_uc011bqo.1_RNA|MCCC1_uc003flf.2_Silent_p.V190V|MCCC1_uc003flg.2_Silent_p.V198V|MCCC1_uc011bqp.1_Silent_p.V260V|MCCC1_uc011bqq.1_Silent_p.V198V	NM_020166	NP_064551	Q96RQ3	MCCA_HUMAN	methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)	307	Biotin carboxylation.|ATP-grasp.				biotin metabolic process|leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|methylcrotonoyl-CoA carboxylase activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.84e-14)|Ovarian(172;0.0355)		all cancers(12;1.8e-44)|Epithelial(37;3.23e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;5.07e-21)		Biotin(DB00121)	TAGCAGCTCTGACTGCAGCTT	0.348		NaN											0	0	0	0.008291	0	7	81									
TNK2	10188	broad.mit.edu	37	3	195608974	195608974	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:195608974G>A	uc003fvu.1	-	6	1378	c.835C>T	c.(835-837)CAG>TAG	p.Q279*	TNK2_uc003fvs.1_Nonsense_Mutation_p.Q311*|TNK2_uc003fvt.1_Nonsense_Mutation_p.Q342*|TNK2_uc010hzw.1_RNA|TNK2_uc003fvv.1_Nonsense_Mutation_p.Q109*|TNK2_uc010hzx.1_Intron	NM_005781	NP_005772	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2 isoform 1	279	Protein kinase.				positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|central_nervous_system(3)|lung(2)|stomach(1)|skin(1)	10	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	TCGTCATTCTGAGGTAGTGCT	0.602		NaN											0	0	0	0.00308	0	6	77									
GAK	2580	broad.mit.edu	37	4	844870	844870	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:844870G>A	uc003gbm.3	-	26	3710	c.3511C>T	c.(3511-3513)CAA>TAA	p.Q1171*	GAK_uc003gbn.3_Nonsense_Mutation_p.Q1092*|GAK_uc003gbk.3_Intron|GAK_uc010ibi.2_Nonsense_Mutation_p.Q396*|GAK_uc010ibj.2_RNA|GAK_uc003gbl.3_Nonsense_Mutation_p.Q1024*	NM_005255	NP_005246	O14976	GAK_HUMAN	cyclin G associated kinase	1171					cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			lung(2)|central_nervous_system(1)|skin(1)	4				Colorectal(103;0.219)		TTTGGCTTTTGAGCTAGAAAA	0.264		NaN											0	0	0	0.000602	0	5	64									
HTT	3064	broad.mit.edu	37	4	3214330	3214330	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:3214330G>A	uc011bvq.1	+	50	6819	c.6674G>A	c.(6673-6675)CGG>CAG	p.R2225Q		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	2223					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		ACTCTGGCCCGGGCCCTGGCA	0.552		NaN											0	0	0	0.008871	0	17	235									
C4orf50	389197	broad.mit.edu	37	4	5961300	5961300	+	Silent	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:5961300G>A	uc003git.1	-	7	723	c.633C>T	c.(631-633)GTC>GTT	p.V211V		NM_207405	NP_997288	Q6ZRC1	CD050_HUMAN	hypothetical protein LOC389197	211										pancreas(2)|breast(1)	3						GTTCCACAGTGACCGCTGCCA	0.577		NaN											0	0	0	0.001984	0	5	44									
KIAA0232	9778	broad.mit.edu	37	4	6843853	6843853	+	Silent	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:6843853G>A	uc003gjr.3	+	4	754	c.291G>A	c.(289-291)AAG>AAA	p.K97K	KIAA0232_uc003gjq.3_Silent_p.K97K	NM_014743	NP_055558	Q92628	K0232_HUMAN	hypothetical protein LOC9778	97							ATP binding			ovary(2)	2						GAAAGAGTAAGAAAAAATGTT	0.388		NaN											0	0	0	0.000978	0	10	104									
BOD1L	259282	broad.mit.edu	37	4	13605601	13605601	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:13605601C>G	uc003gmz.1	-	10	3040	c.2923G>C	c.(2923-2925)GAG>CAG	p.E975Q	BOD1L_uc010idr.1_Missense_Mutation_p.E312Q	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	975	Lys-rich.						DNA binding			ovary(5)|breast(1)	6						GAAGCAGTCTCTAATACAGGT	0.378		NaN											0	0	0	0.00499	0	12	177									
BOD1L	259282	broad.mit.edu	37	4	13605643	13605643	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:13605643C>T	uc003gmz.1	-	10	2998	c.2881G>A	c.(2881-2883)GAA>AAA	p.E961K	BOD1L_uc010idr.1_Missense_Mutation_p.E298K	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	961	Lys-rich.						DNA binding			ovary(5)|breast(1)	6						GGTTTGTCTTCAACTTTAGAC	0.398		NaN											0	0	0	0.006214	0	9	143									
UGDH	7358	broad.mit.edu	37	4	39512009	39512009	+	Silent	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:39512009G>C	uc003guk.1	-	5	943	c.627C>G	c.(625-627)CTC>CTG	p.L209L	UGDH_uc011byp.1_Silent_p.L112L|UGDH_uc003gul.1_Silent_p.L142L	NM_003359	NP_003350	O60701	UGDH_HUMAN	UDP-glucose dehydrogenase	209					glycosaminoglycan biosynthetic process|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	electron carrier activity|NAD binding|UDP-glucose 6-dehydrogenase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4					NADH(DB00157)	TATTAGTGGTGAGGATCTTTT	0.423		NaN											0	0	0	0.008291	0	7	119									
DCAF4L1	285429	broad.mit.edu	37	4	41984112	41984112	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:41984112C>G	uc003gwk.2	+	1	400	c.303C>G	c.(301-303)ATC>ATG	p.I101M		NM_001029955	NP_001025126	Q3SXM0	DC4L1_HUMAN	WD repeat domain 21B	101										skin(1)	1						AGTACGGCATCATCAGCCTGC	0.557		NaN											0	0	0	0.001984	0	6	62									
GABRA2	2555	broad.mit.edu	37	4	46334652	46334652	+	Missense_Mutation	SNP	G	G	T	rs76519302		TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:46334652G>T	uc003gxc.3	-	3	908	c.235C>A	c.(235-237)CCT>ACT	p.P79T	GABRA2_uc010igc.2_Missense_Mutation_p.P79T|GABRA2_uc011bzc.1_Intron|GABRA2_uc003gxe.2_Missense_Mutation_p.P79T	NM_001114175	NP_001107647	P47869	GBRA2_HUMAN	gamma-aminobutyric acid A receptor, alpha 2	79	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|skin(2)	4					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TCTGAGACAGGGCCAAAACTG	0.328		NaN											1	0	1.33987e-11	0.008291	1.47268e-11	7	123									
TEC	7006	broad.mit.edu	37	4	48169865	48169865	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:48169865C>T	uc003gxz.2	-	7	692	c.601G>A	c.(601-603)GAG>AAG	p.E201K		NM_003215	NP_003206	P42680	TEC_HUMAN	tec protein tyrosine kinase	201	SH3.				intracellular protein kinase cascade	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(4)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)	9						TGGCCTCTCTCTAATCTGAGA	0.403		NaN											0	0	0	0.008291	0	10	141									
KDR	3791	broad.mit.edu	37	4	55958791	55958791	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:55958791G>A	uc003has.2	-	22	3364	c.3062C>T	c.(3061-3063)TCG>TTG	p.S1021L	KDR_uc003hat.1_Missense_Mutation_p.S1021L	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	1021	Protein kinase.|Cytoplasmic (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	TACCTTTCGCGATGCCAAGAA	0.458		NaN	Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			0	0	0	0.00308	0	7	59									
CEP135	9662	broad.mit.edu	37	4	56819371	56819371	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:56819371G>C	uc003hbi.2	+	3	468	c.234G>C	c.(232-234)TTG>TTC	p.L78F	CEP135_uc003hbh.1_Missense_Mutation_p.L78F|CEP135_uc010igz.1_5'Flank	NM_025009	NP_079285	Q66GS9	CP135_HUMAN	centrosome protein 4	78	Potential.				centriole replication|centriole-centriole cohesion|G2/M transition of mitotic cell cycle	centriole|cytosol	protein C-terminus binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	Glioma(25;0.08)|all_neural(26;0.101)					ATGCAAGATTGAGTAGAGAAA	0.308		NaN											0	0	0	0.000602	0	5	67									
AMBN	258	broad.mit.edu	37	4	71468378	71468378	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:71468378C>T	uc003hfl.2	+	7	644	c.569C>T	c.(568-570)TCA>TTA	p.S190L		NM_016519	NP_057603	Q9NP70	AMBN_HUMAN	ameloblastin precursor	190	1.				bone mineralization|cell adhesion|cell proliferation|odontogenesis of dentine-containing tooth	proteinaceous extracellular matrix	growth factor activity|structural constituent of tooth enamel			ovary(3)|skin(1)	4			Lung(101;0.235)			CAAGGTCCATCAGTAAGTACA	0.219		NaN											0	0	0	0.004482	0	5	95									
GC	2638	broad.mit.edu	37	4	72634130	72634130	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:72634130C>G	uc003hge.2	-	3	302	c.149G>C	c.(148-150)AGA>ACA	p.R50T	GC_uc003hgd.2_5'UTR|GC_uc010iie.2_Missense_Mutation_p.R50T|GC_uc010iif.2_Missense_Mutation_p.R69T	NM_000583	NP_000574	P02774	VTDB_HUMAN	vitamin D-binding protein precursor	50	Albumin 1.				hormone biosynthetic process|vitamin D metabolic process	cytosol|lysosomal lumen	actin binding|vitamin D binding|vitamin transporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		all_hematologic(202;0.107)	Lung(101;0.148)		Cholecalciferol(DB00169)	GGGAAATTTTCTACTGTACAG	0.388		NaN											0	0	0	0.000602	0	4	59									
MEPE	56955	broad.mit.edu	37	4	88766951	88766951	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:88766951G>A	uc003hqy.2	+	4	970	c.931G>A	c.(931-933)GAA>AAA	p.E311K	MEPE_uc010ikn.2_Missense_Mutation_p.E198K	NM_020203	NP_064588	Q9NQ76	MEPE_HUMAN	matrix, extracellular phosphoglycoprotein with	311					skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			ovary(1)|lung(1)|skin(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000432)		AGAGAGAGAAGAAAATGGTGG	0.448		NaN											0	0	0	0.004482	0	8	41									
INTS12	57117	broad.mit.edu	37	4	106614625	106614625	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:106614625C>T	uc003hxw.2	-	5	586	c.328G>A	c.(328-330)GAA>AAA	p.E110K	INTS12_uc010ilr.2_Missense_Mutation_p.E110K	NM_020395	NP_065128	Q96CB8	INT12_HUMAN	integrator complex subunit 12	110					snRNA processing	integrator complex	protein binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(123;5.12e-07)		TCAACTCCTTCAGTGATGTCT	0.378		NaN											0	0	0	0.008291	0	9	158									
HADH	3033	broad.mit.edu	37	4	108911132	108911132	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:108911132C>T	uc003hyq.2	+	1	193	c.44C>T	c.(43-45)TCG>TTG	p.S15L	HADH_uc010ilx.2_Missense_Mutation_p.S15L|HADH_uc010ily.2_5'UTR	NM_005327	NP_005318	Q16836	HCDH_HUMAN	L-3-hydroxyacyl-Coenzyme A dehydrogenase	15					fatty acid beta-oxidation	mitochondrial matrix	3-hydroxyacyl-CoA dehydrogenase activity|NAD+ binding			ovary(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000168)	NADH(DB00157)	GTGTCCTCCTCGTCCACCGCC	0.687		NaN											0	0	0	0.004672	0	3	37									
SPATA5	166378	broad.mit.edu	37	4	123977578	123977578	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:123977578G>C	uc003iez.3	+	12	2189	c.2116G>C	c.(2116-2118)GAA>CAA	p.E706Q		NM_145207	NP_660208	Q8NB90	SPAT5_HUMAN	spermatogenesis associated 5	706					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrion	ATP binding|nucleoside-triphosphatase activity				0						TGGTGAATCTGAAAGAGCAGT	0.378		NaN											0	0	0	0.00308	0	5	55									
TRIM2	23321	broad.mit.edu	37	4	154237060	154237060	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:154237060C>T	uc003ing.2	+	8	1811	c.1610C>T	c.(1609-1611)ACA>ATA	p.T537I	TRIM2_uc003inh.2_Missense_Mutation_p.T564I	NM_001130067	NP_001123539	Q9C040	TRIM2_HUMAN	tripartite motif-containing 2 isoform 2	537	NHL 2.					cytoplasm	zinc ion binding			central_nervous_system(1)	1	all_hematologic(180;0.093)	Medulloblastoma(177;0.00225)		GBM - Glioblastoma multiforme(119;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0703)		CAGCGGCCCACAGGAGTGGCT	0.448		NaN											0	0	0	0.006214	0	7	89									
NPY5R	4889	broad.mit.edu	37	4	164271709	164271709	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:164271709C>T	uc003iqn.2	+	4	466	c.284C>T	c.(283-285)TCA>TTA	p.S95L		NM_006174	NP_006165	Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	95	Helical; Name=2; (Potential).				cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				lung(6)|skin(1)	7	all_hematologic(180;0.166)	Prostate(90;0.109)				CTGTTTTGCTCACCTTTCACA	0.408		NaN											0	0	0	0.007413	0	18	286									
TKTL2	84076	broad.mit.edu	37	4	164393349	164393349	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:164393349C>T	uc003iqp.3	-	1	1699	c.1538G>A	c.(1537-1539)GGA>GAA	p.G513E		NM_032136	NP_115512	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	513						cytoplasm	metal ion binding|transketolase activity			ovary(2)|skin(2)|pancreas(1)	5	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				GAGAGTAACTCCAGCTCCAAT	0.458		NaN											0	0	0	0.006122	0	17	140									
ODZ3	55714	broad.mit.edu	37	4	183673159	183673159	+	Missense_Mutation	SNP	T	T	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:183673159T>C	uc003ivd.1	+	19	3873	c.3836T>C	c.(3835-3837)GTG>GCG	p.V1279A	ODZ3_uc003ive.1_Missense_Mutation_p.V692A	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	1279	NHL 2.|Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		GGGAAGGCCGTGGAAGCCACA	0.463		NaN											0	0	0	0.001168	0	5	23									
TRIO	7204	broad.mit.edu	37	5	14399069	14399069	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr5:14399069C>T	uc003jff.2	+	30	4510	c.4504C>T	c.(4504-4506)CGA>TGA	p.R1502*	TRIO_uc003jfg.2_RNA|TRIO_uc011cna.1_Nonsense_Mutation_p.R1453*|TRIO_uc003jfh.1_Nonsense_Mutation_p.R1151*	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	1502	PH 1.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					AACCTTAATTCGAAAGGGTCG	0.398		NaN											0	0	0	0.001855	0	11	137									
DAB2	1601	broad.mit.edu	37	5	39392476	39392476	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr5:39392476C>G	uc003jlx.2	-	4	852	c.321G>C	c.(319-321)GAG>GAC	p.E107D	DAB2_uc003jlw.2_Missense_Mutation_p.E107D	NM_001343	NP_001334	P98082	DAB2_HUMAN	disabled homolog 2	107	PID.				cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			kidney(2)|skin(1)	3	all_lung(31;0.000197)		Epithelial(62;0.137)			CCCCAGTTTTCTCATCAATTA	0.458		NaN											0	0	0	0.009096	0	3	48									
HCN1	348980	broad.mit.edu	37	5	45303797	45303797	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr5:45303797C>T	uc003jok.2	-	6	1547	c.1522G>A	c.(1522-1524)GTG>ATG	p.V508M		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	508	cAMP.|Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						TTTTTACCCACGGCTCCTTCT	0.393		NaN											0	0	0	0.004007	0	14	92									
GZMA	3001	broad.mit.edu	37	5	54404206	54404206	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr5:54404206G>A	uc003jpm.2	+	4	648	c.611G>A	c.(610-612)GGA>GAA	p.G204E		NM_006144	NP_006135	P12544	GRAA_HUMAN	granzyme A precursor	204	Peptidase S1.				cleavage of lamin|cytolysis|immune response|negative regulation of DNA binding|negative regulation of endodeoxyribonuclease activity|negative regulation of oxidoreductase activity|positive regulation of apoptosis	extracellular region|immunological synapse|nucleus	protein homodimerization activity|serine-type endopeptidase activity			ovary(2)|pancreas(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.183)				CTCCGAGGTGGAAGAGACTCG	0.378		NaN											0	0	0	0.006214	0	7	87									
GZMA	3001	broad.mit.edu	37	5	54404209	54404209	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr5:54404209G>A	uc003jpm.2	+	4	651	c.614G>A	c.(613-615)AGA>AAA	p.R205K		NM_006144	NP_006135	P12544	GRAA_HUMAN	granzyme A precursor	205	Peptidase S1.				cleavage of lamin|cytolysis|immune response|negative regulation of DNA binding|negative regulation of endodeoxyribonuclease activity|negative regulation of oxidoreductase activity|positive regulation of apoptosis	extracellular region|immunological synapse|nucleus	protein homodimerization activity|serine-type endopeptidase activity			ovary(2)|pancreas(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.183)				CGAGGTGGAAGAGACTCGTGC	0.383		NaN											0	0	0	0.008291	0	8	89									
CD180	4064	broad.mit.edu	37	5	66479570	66479570	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr5:66479570C>G	uc003juy.2	-	3	1249	c.1101G>C	c.(1099-1101)GAG>GAC	p.E367D		NM_005582	NP_005573	Q99467	CD180_HUMAN	CD180 molecule precursor	367	Extracellular (Potential).				inflammatory response|innate immune response	integral to membrane|plasma membrane	receptor activity			ovary(1)	1		Lung NSC(167;4.94e-05)|Prostate(74;0.00601)|Ovarian(174;0.0654)|Breast(144;0.198)|Colorectal(97;0.234)		Lung(70;0.0046)		TTCCTAGTTTCTCCAAGCAGC	0.453		NaN											0	0	0	0.004007	0	14	123									
ARSB	411	broad.mit.edu	37	5	78260315	78260315	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr5:78260315C>T	uc003kfq.2	-	3	1900	c.614G>A	c.(613-615)GGA>GAA	p.G205E	ARSB_uc003kfr.3_Missense_Mutation_p.G205E	NM_000046	NP_000037	P15848	ARSB_HUMAN	arylsulfatase B isoform 1 precursor	205					lysosomal transport|lysosome organization	lysosome	arylsulfatase activity|metal ion binding|N-acetylgalactosamine-4-sulfatase activity			upper_aerodigestive_tract(1)	1		all_lung(232;0.000637)|Lung NSC(167;0.00173)|Ovarian(174;0.0105)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;4.24e-44)|Epithelial(54;3.12e-39)|all cancers(79;3.02e-34)		ATTTTTATATCCTGTTGCAAC	0.373		NaN											0	0	0	0.004482	0	9	60									
CHD1	1105	broad.mit.edu	37	5	98209411	98209411	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr5:98209411G>A	uc003knf.2	-	25	3605	c.3457C>T	c.(3457-3459)CGA>TGA	p.R1153*	CHD1_uc010jbn.2_5'UTR	NM_001270	NP_001261	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	1153					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			lung(2)|ovary(1)|breast(1)|pancreas(1)	5		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	TCAGCATCTCGAGCAATTGCA	0.338		NaN											0	0	0	0.008291	0	10	90									
TNFAIP8	25816	broad.mit.edu	37	5	118728967	118728967	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr5:118728967C>T	uc003ksh.2	+	3	1176	c.488C>T	c.(487-489)TCA>TTA	p.S163L	TNFAIP8_uc003ksf.1_3'UTR|TNFAIP8_uc003ksg.2_Missense_Mutation_p.S153L|TNFAIP8_uc011cwf.1_Missense_Mutation_p.S157L|TNFAIP8_uc003ksi.2_Missense_Mutation_p.S163L	NM_014350	NP_055165	O95379	TFIP8_HUMAN	tumor necrosis factor, alpha-induced protein 8	163					anti-apoptosis|apoptosis|negative regulation of anti-apoptosis	cytoplasm	caspase inhibitor activity|protein binding			ovary(1)	1		all_cancers(142;0.0317)|Prostate(80;0.111)|Breast(839;0.231)		Epithelial(69;4.63e-83)|OV - Ovarian serous cystadenocarcinoma(64;1.39e-82)|all cancers(49;4.88e-75)|GBM - Glioblastoma multiforme(465;0.00338)|BRCA - Breast invasive adenocarcinoma(61;0.0148)|COAD - Colon adenocarcinoma(49;0.0829)		GATCATTTTTCAGATTGTGAA	0.388		NaN											0	0	0	0.001984	0	7	122									
PCDHB7	56129	broad.mit.edu	37	5	140552992	140552992	+	Silent	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr5:140552992C>G	uc003lit.2	+	1	750	c.576C>G	c.(574-576)CCC>CCG	p.P192P		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	192	Extracellular (Potential).|Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATATCTATCCCGAATTGGTGC	0.493		NaN											0	0	0	0.001984	0	6	84									
PCDHB7	56129	broad.mit.edu	37	5	140553379	140553379	+	Silent	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr5:140553379C>T	uc003lit.2	+	1	1137	c.963C>T	c.(961-963)GCC>GCT	p.A321A		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	321	Extracellular (Potential).|Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTATTCAGGCCAAAGACGGCG	0.428		NaN											0	0	0	0.00308	0	6	78									
PCDHB9	56127	broad.mit.edu	37	5	140567301	140567301	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr5:140567301G>C	uc003liw.1	+	1	409	c.409G>C	c.(409-411)GAG>CAG	p.E137Q		NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	137	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCGGCACAAAGAGATGGTCTT	0.403		NaN											0	0	0	0.001168	0	4	73									
PCDHGB3	56102	broad.mit.edu	37	5	140751513	140751513	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr5:140751513C>T	uc003ljw.1	+	1	1552	c.1552C>T	c.(1552-1554)CGA>TGA	p.R518*	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGA6_uc003ljy.1_5'Flank|PCDHGB3_uc011dat.1_Nonsense_Mutation_p.R518*|PCDHGA6_uc011dau.1_5'Flank	NM_018924	NP_061747	Q9Y5G1	PCDGF_HUMAN	protocadherin gamma subfamily B, 3 isoform 1	518	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTTCGCGCAGCGAGCCTTCGA	0.677		NaN											0	0	0	0.001168	0	5	73									
HTR4	3360	broad.mit.edu	37	5	147928367	147928367	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr5:147928367C>T	uc003lpn.2	-	4	381	c.217G>A	c.(217-219)GTG>ATG	p.V73M	HTR4_uc010jgu.1_RNA|HTR4_uc003lpi.1_Missense_Mutation_p.V73M|HTR4_uc003lpj.1_Missense_Mutation_p.V73M|HTR4_uc003lpk.2_Missense_Mutation_p.V73M|HTR4_uc011dby.1_Missense_Mutation_p.V73M|HTR4_uc003lpl.2_Missense_Mutation_p.V73M|HTR4_uc003lpm.2_Missense_Mutation_p.V73M|HTR4_uc010jgv.2_RNA|HTR4_uc003lpo.1_Missense_Mutation_p.V73M	NM_000870	NP_000861	Q13639	5HT4R_HUMAN	serotonin 5-HT4 receptor isoform b	73	Helical; Name=2; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cell proliferation	endosome|integral to plasma membrane|membrane fraction	serotonin receptor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Cisapride(DB00604)|Rizatriptan(DB00953)|Tegaserod(DB01079)|Zolmitriptan(DB00315)	AAGGGCATCACCAGCACCGAA	0.408		NaN											0	0	0	0.001984	0	5	66									
ARSI	340075	broad.mit.edu	37	5	149677553	149677553	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr5:149677553G>A	uc003lrv.2	-	2	1523	c.934C>T	c.(934-936)CGA>TGA	p.R312*		NM_001012301	NP_001012301	Q5FYB1	ARSI_HUMAN	arylsulfatase family, member I precursor	312						endoplasmic reticulum|extracellular region	arylsulfatase activity|metal ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTGCGTCCTCGGAGCGGCCAG	0.592		NaN											0	0	0	0.004482	0	9	78									
DOCK2	1794	broad.mit.edu	37	5	169494582	169494582	+	Missense_Mutation	SNP	G	G	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr5:169494582G>T	uc003maf.2	+	45	4616	c.4536G>T	c.(4534-4536)ATG>ATT	p.M1512I	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.M1004I|DOCK2_uc003mah.2_Missense_Mutation_p.M68I	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1512	DHR-2.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCCTGATGATGATAAACCAGT	0.498		NaN											1	0	5.18039e-06	0.00308	5.50003e-06	7	103									
SH3PXD2B	285590	broad.mit.edu	37	5	171765985	171765985	+	Silent	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr5:171765985G>A	uc003mbr.2	-	13	2295	c.2124C>T	c.(2122-2124)CGC>CGT	p.R708R		NM_001017995	NP_001017995	A1X283	SPD2B_HUMAN	SH3 and PX domains 2B	708					adipose tissue development|bone development|cell communication|cell differentiation|eye development|heart development|podosome assembly	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|SH2 domain binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0207)|all_neural(177;0.0625)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TGTCCTGGGCGCGGCCAGGCC	0.627		NaN											0	0	0	0.001984	0	6	40									
UIMC1	51720	broad.mit.edu	37	5	176370462	176370462	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr5:176370462C>T	uc011dfp.1	-	10	1638	c.1471G>A	c.(1471-1473)GAA>AAA	p.E491K	UIMC1_uc003mfc.1_Missense_Mutation_p.E368K|UIMC1_uc003mfd.1_Missense_Mutation_p.E121K|UIMC1_uc003mfg.1_Missense_Mutation_p.E210K|UIMC1_uc003mfe.1_RNA|UIMC1_uc003mff.1_Missense_Mutation_p.E121K	NM_016290	NP_057374	Q96RL1	UIMC1_HUMAN	ubiquitin interaction motif containing 1	491	Necessary for interaction with NR6A1 C- terminus.				double-strand break repair|G2/M transition DNA damage checkpoint|histone H2A K63-linked deubiquitination|negative regulation of transcription, DNA-dependent|positive regulation of DNA repair|response to ionizing radiation|transcription, DNA-dependent	BRCA1-A complex	histone binding|K63-linked polyubiquitin binding			ovary(3)|skin(1)	4	all_cancers(89;7.96e-05)|Renal(175;0.000269)|Lung NSC(126;0.00476)|all_lung(126;0.00806)	Medulloblastoma(196;0.0145)|all_neural(177;0.0325)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ATAGCTACTTCCTTCTCAGCA	0.433		NaN											0	0	0	0.004482	0	8	100									
ADAMTS2	9509	broad.mit.edu	37	5	178541064	178541064	+	Missense_Mutation	SNP	G	G	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr5:178541064G>T	uc003mjw.2	-	22	3440	c.3440C>A	c.(3439-3441)TCC>TAC	p.S1147Y	uc003mjv.3_5'Flank	NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1147					collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		ATTGGTGCTGGAGGCATTGAG	0.557		NaN											1	0	2.62699e-14	0.003163	2.90658e-14	12	135									
MYLK4	340156	broad.mit.edu	37	6	2683270	2683270	+	Silent	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr6:2683270G>C	uc003mty.3	-	7	969	c.672C>G	c.(670-672)CTC>CTG	p.L224L		NM_001012418	NP_001012418	Q86YV6	MYLK4_HUMAN	myosin light chain kinase family, member 4	224	Protein kinase.						ATP binding|protein serine/threonine kinase activity			breast(3)|ovary(1)	4	Ovarian(93;0.0412)	all_hematologic(90;0.0897)				GGTCCAAGTGGAGAATGTACA	0.488		NaN											0	0	0	0.003954	0	21	124									
HIST1H2AD	3013	broad.mit.edu	37	6	26199108	26199108	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr6:26199108C>G	uc003ngw.2	-	1	364	c.364G>C	c.(364-366)GAG>CAG	p.E122Q	HIST1H3D_uc003ngv.2_5'UTR|HIST1H2BF_uc003ngx.2_5'Flank	NM_021065	NP_066409	P20671	H2A1D_HUMAN	histone cluster 1, H2ad	122					nucleosome assembly	nucleosome|nucleus	DNA binding				0		all_hematologic(11;0.196)				TGGTGACTCTCAGTCTTCTTG	0.488		NaN											0	0	0	0.003163	0	14	83									
HIST1H2AG	8969	broad.mit.edu	37	6	27101102	27101102	+	Silent	SNP	C	C	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr6:27101102C>A	uc003niw.2	+	1	286	c.252C>A	c.(250-252)CTC>CTA	p.L84L	HIST1H2BJ_uc003niu.1_5'Flank|HIST1H2BJ_uc003niv.2_5'Flank	NM_021064	NP_066408	P0C0S8	H2A1_HUMAN	histone cluster 1, H2ag	84					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding				0						CGCGTCATCTCCAACTGGCCA	0.627		NaN											1	0	1.10923e-09	0.00278	1.20853e-09	18	144									
HIST1H3H	8357	broad.mit.edu	37	6	27777942	27777942	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr6:27777942C>T	uc003njm.2	+	1	101	c.91C>T	c.(91-93)CCG>TCG	p.P31S	HIST1H2BL_uc003njl.2_5'Flank	NM_003536	NP_003527	P68431	H31_HUMAN	histone cluster 1, H3h	31					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						GAAGAGCGCTCCGGCCACCGG	0.657		NaN											0	0	0	0.001168	0	5	67									
HLA-G	3135	broad.mit.edu	37	6	29797699	29797699	+	Silent	SNP	G	G	A	rs139184078		TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr6:29797699G>A	uc003nnw.2	+	6	1180	c.1002G>A	c.(1000-1002)AAG>AAA	p.K334K	HLA-G_uc011dmb.1_Silent_p.K306K|HLA-G_uc003raj.3_Silent_p.K339K|HLA-G_uc003nnz.3_Silent_p.K242K|HLA-G_uc010jrn.2_Silent_p.K150K|HLA-G_uc003nny.3_RNA|HLA-G_uc003ran.1_RNA	NM_002127	NP_002118	P17693	HLAG_HUMAN	major histocompatibility complex, class I, G	334	Cytoplasmic (Potential).				antigen processing and presentation of peptide antigen via MHC class I|cellular defense response|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity			ovary(3)|central_nervous_system(1)	4						TGTGGAGAAAGAAGAGCTCAG	0.572		NaN											0	0	0	0.00245	0	13	89									
APOM	55937	broad.mit.edu	37	6	31625244	31625244	+	Missense_Mutation	SNP	T	T	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr6:31625244T>G	uc003nvl.2	+	4	504	c.431T>G	c.(430-432)TTT>TGT	p.F144C	APOM_uc003nvk.2_Missense_Mutation_p.F72C	NM_019101	NP_061974	O95445	APOM_HUMAN	apolipoprotein M	144					cholesterol efflux|high-density lipoprotein particle assembly|high-density lipoprotein particle clearance|high-density lipoprotein particle remodeling|negative regulation of plasma lipoprotein particle oxidation|reverse cholesterol transport	discoidal high-density lipoprotein particle|integral to plasma membrane|low-density lipoprotein particle|spherical high-density lipoprotein particle|very-low-density lipoprotein particle	binding|lipid transporter activity				0						TACCAGCGCTTTCTCCTCTAC	0.562		NaN											0	0	0	0.001168	0	5	75									
HSPA1A	3303	broad.mit.edu	37	6	31785445	31785445	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr6:31785445G>A	uc003nxj.2	+	1	2155	c.1912G>A	c.(1912-1914)GAG>AAG	p.E638K	HSPA1L_uc003nxh.2_5'Flank|HSPA1L_uc010jte.2_5'Flank|HSPA1A_uc003nxi.1_Missense_Mutation_p.E473K|uc011dok.1_RNA	NM_005345	NP_005336	P08107	HSP71_HUMAN	heat shock 70kDa protein 1A	638					anti-apoptosis|mRNA catabolic process|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of inclusion body assembly|protein refolding|response to unfolded protein	cytosol|endoplasmic reticulum|inclusion body|mitochondrion|nuclear speck|perinuclear region of cytoplasm|ribonucleoprotein complex	ATP binding|protein binding involved in protein folding|protein N-terminus binding|receptor activity|ubiquitin protein ligase binding|unfolded protein binding			ovary(1)	1						CCCCACCATTGAGGAGGTAGA	0.547		NaN											0	0	0	0.00308	0	6	83									
CUL7	9820	broad.mit.edu	37	6	43012542	43012542	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr6:43012542C>G	uc003otq.2	-	16	3423	c.3120G>C	c.(3118-3120)AAG>AAC	p.K1040N	CUL7_uc010jyg.2_Missense_Mutation_p.K319N|CUL7_uc011dvb.1_Missense_Mutation_p.K1124N|CUL7_uc010jyh.2_Intron|KLC4_uc003otr.1_Intron	NM_014780	NP_055595	Q14999	CUL7_HUMAN	cullin 7	1040					interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			ovary(3)|kidney(1)	4			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			CCCAGCAGGTCTTGCCCAGAG	0.597		NaN											0	0	0	0.00308	0	7	97									
MED23	9439	broad.mit.edu	37	6	131923477	131923477	+	Nonsense_Mutation	SNP	G	G	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr6:131923477G>T	uc003qcs.1	-	17	2150	c.1976C>A	c.(1975-1977)TCA>TAA	p.S659*	MED23_uc003qcq.2_Nonsense_Mutation_p.S665*|MED23_uc011eca.1_Nonsense_Mutation_p.S300*|MED23_uc003qct.1_Nonsense_Mutation_p.S665*|MED23_uc011ecb.1_RNA	NM_004830	NP_004821	Q9ULK4	MED23_HUMAN	mediator complex subunit 23 isoform a	659					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor complex	protein binding|transcription coactivator activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0115)|OV - Ovarian serous cystadenocarcinoma(155;0.0608)		TTGTACCTCTGAGCTACCTAA	0.403		NaN											1	0	5.18039e-06	0.00308	5.50003e-06	6	70									
VIP	7432	broad.mit.edu	37	6	153073417	153073417	+	Silent	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr6:153073417C>T	uc003qpe.2	+	2	277	c.105C>T	c.(103-105)CTC>CTT	p.L35L	VIP_uc003qpf.2_Silent_p.L35L|VIP_uc010kjd.2_Silent_p.L35L	NM_003381	NP_003372	P01282	VIP_HUMAN	vasoactive intestinal peptide isoform 1	35					body fluid secretion|G-protein coupled receptor protein signaling pathway|positive regulation of cell proliferation	extracellular region	neuropeptide hormone activity				0		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;4.5e-11)|BRCA - Breast invasive adenocarcinoma(81;0.144)		CTTCTGCTCTCAGGTAAGTTC	0.423		NaN											0	0	0	0.001168	0	6	41									
SLC22A2	6582	broad.mit.edu	37	6	160663435	160663435	+	Splice_Site	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr6:160663435C>G	uc003qtf.2	-	8	1450	c.1280_splice	c.e8-1	p.D427_splice	SLC22A2_uc003qte.1_Splice_Site_p.D427_splice	NM_003058	NP_003049	O15244	S22A2_HUMAN	solute carrier family 22 member 2						body fluid secretion|neurotransmitter biosynthetic process|neurotransmitter secretion	integral to plasma membrane|membrane fraction	neurotransmitter transporter activity|organic cation transmembrane transporter activity			breast(1)|skin(1)	2		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.28e-17)|BRCA - Breast invasive adenocarcinoma(81;6.29e-06)		CATTGTAGATCTAAGAGGGAA	0.448		NaN											0	0	0	0.004482	0	8	65									
RNASET2	8635	broad.mit.edu	37	6	167352457	167352457	+	Silent	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr6:167352457C>T	uc003qve.2	-	6	779	c.372G>A	c.(370-372)CAG>CAA	p.Q124Q	RNASET2_uc003qvh.2_Intron|RNASET2_uc003qvf.2_Silent_p.Q32Q|RNASET2_uc003qvg.2_Silent_p.Q61Q|RNASET2_uc003qvi.1_Missense_Mutation_p.R12K	NM_003730	NP_003721	O00584	RNT2_HUMAN	ribonuclease T2 precursor	124					RNA catabolic process	extracellular region	ribonuclease T2 activity|RNA binding				0		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;1.53e-19)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00665)		GCGCATCCACCTGGGCGGCGC	0.498		NaN											0	0	0	0.001368	0	9	110									
EIF2AK1	27102	broad.mit.edu	37	7	6080762	6080762	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:6080762C>T	uc003spp.2	-	9	1026	c.880G>A	c.(880-882)GAA>AAA	p.E294K	EIF2AK1_uc003spq.2_Missense_Mutation_p.E293K|EIF2AK1_uc011jwm.1_Missense_Mutation_p.E170K|EIF2AK1_uc003spr.1_Missense_Mutation_p.E86K	NM_014413	NP_055228	Q9BQI3	E2AK1_HUMAN	eukaryotic translation initiation factor 2-alpha	294	Protein kinase.				negative regulation of hemoglobin biosynthetic process|negative regulation of translational initiation by iron|protein autophosphorylation|response to external stimulus|response to stress	cytoplasm	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|heme binding|protein homodimerization activity			upper_aerodigestive_tract(1)|stomach(1)|lung(1)|central_nervous_system(1)	4		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.106)|OV - Ovarian serous cystadenocarcinoma(56;5.22e-14)		GTGTCAGATTCTCCAAAGCGT	0.408		NaN											0	0	0	0.003163	0	15	125									
RAC1	5879	broad.mit.edu	37	7	6431604	6431604	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:6431604C>G	uc003spx.2	+	3	398	c.157C>G	c.(157-159)CTG>GTG	p.L53V	RAC1_uc003spw.2_Missense_Mutation_p.L53V	NM_006908	NP_008839	P63000	RAC1_HUMAN	ras-related C3 botulinum toxin substrate 1	53					actin filament polymerization|apoptosis|axon guidance|cell motility|cell-matrix adhesion|induction of apoptosis by extracellular signals|inflammatory response|lamellipodium assembly|localization within membrane|negative regulation of interleukin-23 production|negative regulation of receptor-mediated endocytosis|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of lamellipodium assembly|positive regulation of Rho protein signal transduction|regulation of cell migration|regulation of defense response to virus by virus|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|ruffle organization|small GTPase mediated signal transduction|T cell costimulation|viral reproduction	cytosol|melanosome|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity|thioesterase binding			lung(2)	2		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.104)	Pravastatin(DB00175)|Simvastatin(DB00641)	ACCGGTGAATCTGGGCTTATG	0.413		NaN											0	0	0	0.006214	0	9	129									
MEOX2	4223	broad.mit.edu	37	7	15652020	15652020	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:15652020G>A	uc003stc.2	-	3	1188	c.907C>T	c.(907-909)CAC>TAC	p.H303Y	MEOX2_uc011jxw.1_Missense_Mutation_p.H303Y	NM_005924	NP_005915	P50222	MEOX2_HUMAN	mesenchyme homeobox 2	303					blood circulation|multicellular organismal development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (126;0.0822)		TATCATAAGTGCGCATGCTCT	0.478		NaN											0	0	0	0.004482	0	8	64									
AHR	196	broad.mit.edu	37	7	17382605	17382605	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:17382605C>T	uc011jxz.1	+	11	3077	c.2464C>T	c.(2464-2466)CAG>TAG	p.Q822*	AHR_uc003stt.3_RNA	NM_001621	NP_001612	P35869	AHR_HUMAN	aryl hydrocarbon receptor precursor	822				LNETYPAELNNINNTQTTTHLQPLHHPSEARPFPDLTSSGF L -> FK (in Ref. 1; BAA03857).	apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			urinary_tract(1)|kidney(1)|pancreas(1)	3	Lung NSC(10;0.0392)|all_lung(11;0.0754)					AAATAACACTCAGACTACCAC	0.368		NaN											0	0	0	0.00278	0	20	135									
PDE1C	5137	broad.mit.edu	37	7	31862716	31862716	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:31862716C>T	uc003tcm.1	-	14	2022	c.1553G>A	c.(1552-1554)CGG>CAG	p.R518Q	PDE1C_uc003tcn.1_Missense_Mutation_p.R518Q|PDE1C_uc003tco.1_Missense_Mutation_p.R578Q|PDE1C_uc003tcr.2_Missense_Mutation_p.R518Q|PDE1C_uc003tcs.2_Missense_Mutation_p.R518Q	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	518	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			CCATCTCTCCCGATTGATGTG	0.473		NaN											0	0	0	0.000978	0	11	185									
MYO1G	64005	broad.mit.edu	37	7	45016619	45016619	+	Silent	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:45016619C>T	uc003tmh.2	-	2	291	c.147G>A	c.(145-147)GTG>GTA	p.V49V	MYO1G_uc003tmg.2_5'Flank|MYO1G_uc010kym.2_Intron|MYO1G_uc003tmi.1_5'UTR|MYO1G_uc003tmj.2_5'UTR	NM_033054	NP_149043	B0I1T2	MYO1G_HUMAN	myosin IG	49	Myosin head-like.		V -> M (in allele HA-2M; the HA-2V allele constitute the HA-2 epitope while HA-2M is not recognized by HA-2 cytotoxic T lymphocytes).			myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|ovary(1)|pancreas(1)	4						GGTAGGGGTTCACGGACACCA	0.627		NaN											0	0	0	0.004007	0	13	94									
WBSCR17	64409	broad.mit.edu	37	7	71036334	71036334	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:71036334C>G	uc003tvy.2	+	6	1027	c.1027C>G	c.(1027-1029)CTG>GTG	p.L343V	WBSCR17_uc003tvz.2_Missense_Mutation_p.L42V	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	343	Catalytic subdomain B.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				AATTGGTCTTCTGGATCCTGG	0.498		NaN											0	0	0	0.008291	0	9	154									
CALCR	799	broad.mit.edu	37	7	93108727	93108727	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:93108727C>T	uc003umv.1	-	4	459	c.198G>A	c.(196-198)ATG>ATA	p.M66I	CALCR_uc003ums.1_RNA|CALCR_uc003umt.1_RNA|CALCR_uc003umu.1_Missense_Mutation_p.M48I|CALCR_uc003umw.2_Missense_Mutation_p.M48I	NM_001742	NP_001733	P30988	CALCR_HUMAN	calcitonin receptor isoform 2 precursor	48	Extracellular (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin binding|calcitonin receptor activity|calcitonin receptor activity|protein binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	GTGCATCCATCATCTTCTTTC	0.413		NaN											0	0	0	0.002299	0	16	209									
STAG3	10734	broad.mit.edu	37	7	99796487	99796487	+	Silent	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:99796487G>A	uc003utx.1	+	14	1529	c.1374G>A	c.(1372-1374)GAG>GAA	p.E458E	STAG3_uc010lgs.1_Silent_p.E246E|STAG3_uc011kjk.1_Silent_p.E400E|STAG3_uc003uub.1_5'Flank	NM_012447	NP_036579	Q9UJ98	STAG3_HUMAN	stromal antigen 3	458					chromosome segregation|synaptonemal complex assembly	chromosome, centromeric region|meiotic cohesin complex|synaptonemal complex	binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CTGAGTGCGAGATAAGAATGA	0.547		NaN											0	0	0	0.000978	0	9	125									
CTTNBP2	83992	broad.mit.edu	37	7	117431578	117431578	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:117431578G>A	uc003vjf.2	-	4	1764	c.1672C>T	c.(1672-1674)CCA>TCA	p.P558S		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	558	Pro-rich.									ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		GGGTGTGGTGGAGAAGGAGTT	0.502		NaN											0	0	0	0.008291	0	9	140									
CADPS2	93664	broad.mit.edu	37	7	122130198	122130198	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:122130198G>A	uc010lkp.2	-	11	1952	c.1789C>T	c.(1789-1791)CCT>TCT	p.P597S	CADPS2_uc003vkg.3_Missense_Mutation_p.P297S|CADPS2_uc010lkq.2_Missense_Mutation_p.P597S	NM_017954	NP_060424	Q86UW7	CAPS2_HUMAN	Ca2+-dependent activator protein for secretion 2	597					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			ovary(1)|central_nervous_system(1)	2						TGAATTGCAGGAACTGGTTTA	0.368		NaN											0	0	0	0.001168	0	5	83									
POT1	25913	broad.mit.edu	37	7	124503433	124503433	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:124503433C>T	uc003vlm.2	-	8	1118	c.517G>A	c.(517-519)GAA>AAA	p.E173K	POT1_uc011koe.1_RNA|POT1_uc003vlk.2_RNA|POT1_uc003vll.2_RNA|POT1_uc003vlo.2_Missense_Mutation_p.E42K|POT1_uc003vln.2_RNA	NM_015450	NP_056265	Q9NUX5	POTE1_HUMAN	protection of telomeres 1 isoform 1	173					DNA duplex unwinding|negative regulation of telomere maintenance via telomerase|positive regulation of DNA strand elongation|positive regulation of helicase activity|positive regulation of telomerase activity|positive regulation of telomere maintenance via telomerase|telomere capping|telomere formation via telomerase|telomere maintenance via telomerase	nuclear telomere cap complex|nucleoplasm	DEAD/H-box RNA helicase binding|single-stranded telomeric DNA binding|telomerase inhibitor activity			central_nervous_system(1)	1						CCGTCCACTTCTGCTTTGCCC	0.388		NaN											0	0	0	0.006122	0	14	96									
SMO	6608	broad.mit.edu	37	7	128845541	128845541	+	Missense_Mutation	SNP	G	G	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:128845541G>T	uc003vor.2	+	4	1118	c.838G>T	c.(838-840)GGC>TGC	p.G280C	SMO_uc003vos.2_5'Flank	NM_005631	NP_005622	Q99835	SMO_HUMAN	smoothened precursor	280	Helical; Name=2; (Potential).				adenohypophysis development|axon extension involved in axon guidance|canonical Wnt receptor signaling pathway|cardioblast differentiation|central nervous system neuron differentiation|cerebellar cortex morphogenesis|ciliary receptor clustering involved in smoothened signaling pathway|determination of left/right symmetry|dorsal/ventral neural tube patterning|embryonic camera-type eye development|embryonic digestive tract morphogenesis|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis|exocrine pancreas development|facial nerve development|floor plate formation|gonad development|heart morphogenesis|muscle cell fate commitment|negative regulation of apoptosis|neural crest cell migration|neuron fate commitment|neuron projection regeneration|odontogenesis of dentine-containing tooth|osteoblast differentiation|otolith morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of neuroblast proliferation|positive regulation of smoothened signaling pathway|semicircular canal morphogenesis|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|smoothened signaling pathway involved in ventral spinal cord patterning|spermatogenesis|vasculogenesis	cilium|cytoplasm|integral to membrane|neuronal cell body|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			skin(19)|large_intestine(10)|central_nervous_system(3)|upper_aerodigestive_tract(2)|biliary_tract(1)|lung(1)|liver(1)	37						GGGCAGCATTGGCTGGCTGGC	0.582		NaN	Mis		skin basal cell 								1	0	4.26978e-12	0.00333	4.70335e-12	19	79									
LUC7L2	51631	broad.mit.edu	37	7	139026236	139026236	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:139026236C>G	uc011kqt.1	+	1	340	c.106C>G	c.(106-108)CGG>GGG	p.R36G	LUC7L2_uc011kqs.1_Intron|C7orf55_uc003vuw.3_Missense_Mutation_p.R36G	NM_016019	NP_057103	Q9Y383	LC7L2_HUMAN	LUC7-like 2	Error:Variant_position_missing_in_Q9Y383_after_alignment							enzyme binding|metal ion binding				0	Melanoma(164;0.242)					CGCGGCCTATCGGTACCTTGT	0.657		NaN									OREG0018357	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00308	0	8	76									
SLC37A3	84255	broad.mit.edu	37	7	140051177	140051177	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:140051177C>T	uc003vvo.2	-	9	944	c.778G>A	c.(778-780)GAA>AAA	p.E260K	SLC37A3_uc003vvp.2_Missense_Mutation_p.E260K|SLC37A3_uc010lnh.2_Missense_Mutation_p.E260K|SLC37A3_uc011kqz.1_RNA|SLC37A3_uc011kra.1_3'UTR|SLC37A3_uc011krb.1_3'UTR	NM_207113	NP_996996	Q8NCC5	SPX3_HUMAN	solute carrier family 37 (glycerol-3-phosphate	260					carbohydrate transport|transmembrane transport	integral to membrane				ovary(3)	3	Melanoma(164;0.0142)					TATTCGTCTTCATTTTCACCA	0.378		NaN											0	0	0	0.00245	0	10	127									
SLC37A3	84255	broad.mit.edu	37	7	140051237	140051237	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:140051237C>G	uc003vvo.2	-	9	884	c.718G>C	c.(718-720)GAG>CAG	p.E240Q	SLC37A3_uc003vvp.2_Missense_Mutation_p.E240Q|SLC37A3_uc010lnh.2_Missense_Mutation_p.E240Q|SLC37A3_uc011kqz.1_RNA|SLC37A3_uc011kra.1_3'UTR|SLC37A3_uc011krb.1_3'UTR	NM_207113	NP_996996	Q8NCC5	SPX3_HUMAN	solute carrier family 37 (glycerol-3-phosphate	240					carbohydrate transport|transmembrane transport	integral to membrane				ovary(3)	3	Melanoma(164;0.0142)					TCTTCTGCCTCAATACCCGAG	0.229		NaN											0	0	0	0.009096	0	4	82									
BRAF	673	broad.mit.edu	37	7	140494157	140494157	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:140494157G>A	uc003vwc.3	-	8	1152	c.1091C>T	c.(1090-1092)TCA>TTA	p.S364L		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	364					activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding		KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	GGGAGCTGATGAGGATCGGTC	0.408		61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				0	0	0	0.004007	0	13	123									
C7orf34	135927	broad.mit.edu	37	7	142636653	142636653	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:142636653G>A	uc003wca.2	+	1	51	c.10G>A	c.(10-12)GAG>AAG	p.E4K		NM_178829	NP_849151	Q96L11	CG034_HUMAN	hypothetical protein LOC135927	Error:Variant_position_missing_in_Q96L11_after_alignment						extracellular region					0	Melanoma(164;0.059)					AATGGGGCAGGAGGTGCACGG	0.627		NaN											0	0	0	0.001984	0	5	36									
FASTK	10922	broad.mit.edu	37	7	150777000	150777000	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:150777000G>A	uc003wix.1	-	2	190	c.92C>T	c.(91-93)TCA>TTA	p.S31L	FASTK_uc003wiw.1_Intron|FASTK_uc003wiy.1_Intron|FASTK_uc003wiz.1_Missense_Mutation_p.S31L|FASTK_uc003wja.1_5'UTR	NM_006712	NP_006703	Q14296	FASTK_HUMAN	Fas-activated serine/threonine kinase isoform 1	31					apoptosis|induction of apoptosis by extracellular signals|regulation of RNA splicing		ATP binding|Fas-activated serine/threonine kinase activity|protein binding			lung(2)|stomach(2)	4			OV - Ovarian serous cystadenocarcinoma(82;0.00989)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)|LUSC - Lung squamous cell carcinoma(290;0.0718)|Lung(243;0.138)		GGAGTTGGGTGATGGAGACCC	0.582		NaN											0	0	0	0.001168	0	5	9									
RHEB	6009	broad.mit.edu	37	7	151188091	151188091	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:151188091G>A	uc003wkh.1	-	2	475	c.62C>T	c.(61-63)TCA>TTA	p.S21L		NM_005614	NP_005605	Q15382	RHEB_HUMAN	Ras homolog enriched in brain precursor	21	GTP.				cell cycle arrest|insulin receptor signaling pathway|positive regulation of TOR signaling cascade|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity|metal ion binding|protein binding			large_intestine(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.00306)	UCEC - Uterine corpus endometrioid carcinoma (81;0.174)		AATCGTCAATGAGGATTTCCC	0.323		NaN											0	0	0	0.009096	0	4	69									
LZTS1	11178	broad.mit.edu	37	8	20110556	20110556	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr8:20110556C>T	uc003wzr.2	-	2	997	c.886G>A	c.(886-888)GAG>AAG	p.E296K	LZTS1_uc010ltg.1_Missense_Mutation_p.E296K	NM_021020	NP_066300	Q9Y250	LZTS1_HUMAN	leucine zipper, putative tumor suppressor 1	296	Potential.				cell cycle|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	cell junction|dendritic spine|Golgi apparatus|nucleolus|nucleoplasm|postsynaptic density|postsynaptic membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				Colorectal(74;0.0511)|COAD - Colon adenocarcinoma(73;0.207)		GGCCGCTCCTCGTAGGCCAGG	0.677		NaN											0	0	0	0.001984	0	5	47									
NEFM	4741	broad.mit.edu	37	8	24776021	24776021	+	Missense_Mutation	SNP	G	G	A	rs150229714		TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr8:24776021G>A	uc003xed.3	+	3	2686	c.2653G>A	c.(2653-2655)GAG>AAG	p.E885K	NEFM_uc011lac.1_Missense_Mutation_p.E667K|NEFM_uc010lue.2_Missense_Mutation_p.E509K	NM_005382	NP_005373	P07197	NFM_HUMAN	neurofilament, medium polypeptide 150kDa isoform	885	Tail.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(1)	1		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		AAAGGTTGAAGAGCATGAAGA	0.428		NaN											0	0	0	0.006214	0	7	140									
GNRH1	2796	broad.mit.edu	37	8	25280738	25280738	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr8:25280738C>T	uc003xem.3	-	2	950	c.109G>A	c.(109-111)GAT>AAT	p.D37N	PPP2R2A_uc003xek.2_Intron|GNRH1_uc003xen.3_Missense_Mutation_p.D37N	NM_001083111	NP_001076580	P01148	GON1_HUMAN	gonadotropin-releasing hormone 1 precursor	37					cell-cell signaling|multicellular organismal development|negative regulation of cell proliferation|signal transduction	soluble fraction	gonadotropin hormone-releasing hormone activity			large_intestine(1)	1		all_cancers(63;0.0423)|Ovarian(32;0.000626)|all_epithelial(46;0.0186)|Hepatocellular(4;0.114)|Breast(100;0.14)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0201)|Epithelial(17;1.25e-12)|Colorectal(74;0.0113)|COAD - Colon adenocarcinoma(73;0.0385)		TTTTCGGCATCTCTCTTTCCT	0.408		NaN											0	0	0	0.001855	0	11	142									
KIF13B	23303	broad.mit.edu	37	8	28974498	28974498	+	Silent	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr8:28974498G>A	uc003xhh.3	-	31	3746	c.3687C>T	c.(3685-3687)TCC>TCT	p.S1229S	uc003xhi.1_Intron	NM_015254	NP_056069	Q9NQT8	KI13B_HUMAN	kinesin family member 13B	1229					microtubule-based movement|protein targeting|signal transduction|T cell activation	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein kinase binding				0		Ovarian(32;0.000536)		KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)		CATGCACCGCGGAGTCCCAGG	0.577		NaN											0	0	0	0.001168	0	5	101									
CHD7	55636	broad.mit.edu	37	8	61735145	61735145	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr8:61735145G>A	uc003xue.2	+	12	3518	c.3041G>A	c.(3040-3042)GGA>GAA	p.G1014E	CHD7_uc003xuf.2_Missense_Mutation_p.G127E	NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	1014	Helicase ATP-binding.				central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			TATTTGAAAGGAATCCATGGC	0.408		NaN											0	0	0	0.006122	0	15	223									
CHD7	55636	broad.mit.edu	37	8	61749458	61749458	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr8:61749458G>A	uc003xue.2	+	17	4549	c.4072G>A	c.(4072-4074)GAT>AAT	p.D1358N		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	1358	Helicase C-terminal.				central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			ACCTGATTCTGATAGGTTTGT	0.483		NaN											0	0	0	0.00361	0	53	198									
TRIM55	84675	broad.mit.edu	37	8	67040613	67040613	+	Silent	SNP	T	T	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr8:67040613T>C	uc003xvv.2	+	2	469	c.243T>C	c.(241-243)TGT>TGC	p.C81C	TRIM55_uc003xvu.2_Silent_p.C81C|TRIM55_uc003xvw.2_Silent_p.C81C|TRIM55_uc003xvx.2_Silent_p.C81C	NM_184085	NP_908973	Q9BYV6	TRI55_HUMAN	tripartite motif-containing 55 isoform 1	81						cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			GCCCATCCTGTAGACATGAAG	0.498		NaN											0	0	0	0.00361	0	61	197									
SLCO5A1	81796	broad.mit.edu	37	8	70744345	70744345	+	Silent	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr8:70744345G>A	uc003xyl.2	-	2	1271	c.564C>T	c.(562-564)TTC>TTT	p.F188F	SLCO5A1_uc010lzb.2_Silent_p.F188F|SLCO5A1_uc011lfa.1_RNA|SLCO5A1_uc003xyk.2_Silent_p.F188F|SLCO5A1_uc010lzc.2_Silent_p.F188F	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	188	Helical; Name=2; (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			CCCGGCCGCCGAAGTAGCTGA	0.642		NaN											0	0	0	0.001168	0	4	76									
NBN	4683	broad.mit.edu	37	8	90990452	90990452	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr8:90990452C>T	uc003yej.1	-	5	690	c.580G>A	c.(580-582)GAA>AAA	p.E194K	NBN_uc003yei.1_Missense_Mutation_p.E112K|NBN_uc011lgb.1_Missense_Mutation_p.E194K	NM_002485	NP_002476	O60934	NBN_HUMAN	nibrin	194					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|DNA duplex unwinding|double-strand break repair via homologous recombination|meiosis|mitotic cell cycle G1/S transition checkpoint|mitotic cell cycle G2/M transition DNA damage checkpoint|positive regulation of kinase activity|positive regulation of protein autophosphorylation|regulation of DNA-dependent DNA replication initiation|telomere maintenance	Mre11 complex|nuclear chromosome, telomeric region|nuclear inclusion body|nucleolus|nucleoplasm	protein N-terminus binding|transcription factor binding			central_nervous_system(3)|kidney(3)|lung(1)	7			BRCA - Breast invasive adenocarcinoma(11;0.0344)			ATATACCTTTCAATTTGTGGA	0.323		NaN						Direct_reversal_of_damage|Homologous_recombination	Nijmegen_Breakage_syndrome				0	0	0	0.000602	0	5	71									
NBN	4683	broad.mit.edu	37	8	90993657	90993657	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr8:90993657C>T	uc003yej.1	-	3	376	c.266G>A	c.(265-267)CGA>CAA	p.R89Q	NBN_uc003yei.1_Missense_Mutation_p.R7Q|NBN_uc011lgb.1_Missense_Mutation_p.R89Q	NM_002485	NP_002476	O60934	NBN_HUMAN	nibrin	89					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|DNA duplex unwinding|double-strand break repair via homologous recombination|meiosis|mitotic cell cycle G1/S transition checkpoint|mitotic cell cycle G2/M transition DNA damage checkpoint|positive regulation of kinase activity|positive regulation of protein autophosphorylation|regulation of DNA-dependent DNA replication initiation|telomere maintenance	Mre11 complex|nuclear chromosome, telomeric region|nuclear inclusion body|nucleolus|nucleoplasm	protein N-terminus binding|transcription factor binding			central_nervous_system(3)|kidney(3)|lung(1)	7			BRCA - Breast invasive adenocarcinoma(11;0.0344)			CTTCAAAGTTCGGGAAAAGCC	0.333		NaN						Direct_reversal_of_damage|Homologous_recombination	Nijmegen_Breakage_syndrome				0	0	0	0.004482	0	8	173									
SLC26A7	115111	broad.mit.edu	37	8	92374633	92374633	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr8:92374633G>C	uc003yex.2	+	13	1645	c.1367G>C	c.(1366-1368)GGA>GCA	p.G456A	SLC26A7_uc003yey.2_RNA|SLC26A7_uc003yez.2_Missense_Mutation_p.G456A|SLC26A7_uc003yfa.2_Missense_Mutation_p.G456A	NM_052832	NP_439897	Q8TE54	S26A7_HUMAN	solute carrier family 26, member 7 isoform a	456	Helical; (Potential).					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.00802)			GCCAATGTGGGACTGCTGTTT	0.393		NaN											0	0	0	0.003755	0	27	302									
ESRP1	54845	broad.mit.edu	37	8	95658419	95658419	+	Missense_Mutation	SNP	C	C	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr8:95658419C>A	uc003ygq.3	+	4	582	c.399C>A	c.(397-399)TTC>TTA	p.F133L	ESRP1_uc003ygr.3_Missense_Mutation_p.F133L|ESRP1_uc003ygs.3_Missense_Mutation_p.F133L|ESRP1_uc003ygt.3_Missense_Mutation_p.F133L|ESRP1_uc003ygu.3_Missense_Mutation_p.F133L|ESRP1_uc003ygv.2_5'UTR|ESRP1_uc003ygw.2_5'UTR	NM_017697	NP_060167	Q6NXG1	ESRP1_HUMAN	RNA binding motif protein 35A isoform 1	133					mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	prostate(4)	4						CTGAATGCTTCTATTCCTTTT	0.363		NaN											1	0	0.000157383	0.00308	0.000163955	7	119									
MTDH	92140	broad.mit.edu	37	8	98718973	98718973	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr8:98718973C>T	uc003yhz.2	+	8	1595	c.1267C>T	c.(1267-1269)CAA>TAA	p.Q423*	MTDH_uc010mbf.2_RNA	NM_178812	NP_848927	Q86UE4	LYRIC_HUMAN	metadherin	423	Lung-homing for mammary tumors (By similarity).|Cytoplasmic (Potential).				lipopolysaccharide-mediated signaling pathway|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of angiogenesis|positive regulation of autophagy|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein kinase B signaling cascade	apical plasma membrane|endoplasmic reticulum membrane|integral to membrane|intercellular canaliculus|nuclear body|nuclear membrane|nucleolus|perinuclear region of cytoplasm|tight junction	NF-kappaB binding|RNA polymerase II transcription factor binding|transcription coactivator activity			liver(1)|central_nervous_system(1)	2	Breast(36;2.56e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.178)			TCCTGATGATCAAAAGGTGAG	0.323		NaN											0	0	0	0.004482	0	8	209									
LRP12	29967	broad.mit.edu	37	8	105511661	105511661	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr8:105511661C>T	uc003yma.2	-	4	454	c.359G>A	c.(358-360)AGA>AAA	p.R120K	LRP12_uc003ymb.2_Missense_Mutation_p.R101K	NM_013437	NP_038465	Q9Y561	LRP12_HUMAN	low density lipoprotein-related protein 12	120	Extracellular (Potential).|CUB 1.				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			ACCACAAGCTCTGTAACTTTC	0.373		NaN											0	0	0	0.001984	0	7	102									
PKHD1L1	93035	broad.mit.edu	37	8	110487424	110487424	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr8:110487424C>T	uc003yne.2	+	51	8787	c.8683C>T	c.(8683-8685)CAC>TAC	p.H2895Y		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	2895	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AAATGCAAATCACATTAACTG	0.338		NaN								HNSCC(38;0.096)			0	0	0	0.004656	0	23	35									
PKHD1L1	93035	broad.mit.edu	37	8	110495274	110495274	+	Silent	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr8:110495274C>G	uc003yne.2	+	57	9620	c.9516C>G	c.(9514-9516)CTC>CTG	p.L3172L		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	3172	Extracellular (Potential).|G8 2.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AAACTAAGCTCTCAGAAACTG	0.388		NaN								HNSCC(38;0.096)			0	0	0	0.001984	0	5	38									
CSMD3	114788	broad.mit.edu	37	8	114326926	114326926	+	Missense_Mutation	SNP	G	G	T	rs111400281		TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr8:114326926G>T	uc003ynu.2	-	2	434	c.275C>A	c.(274-276)ACA>AAA	p.T92K	CSMD3_uc003ynt.2_Missense_Mutation_p.T52K|CSMD3_uc011lhx.1_Missense_Mutation_p.T92K|CSMD3_uc010mcx.1_Missense_Mutation_p.T92K|CSMD3_uc003ynx.3_Missense_Mutation_p.T92K	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	92	Extracellular (Potential).|CUB 1.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TATTACCCATGTGCAGTTTGC	0.343		NaN								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			1	0	4.68919e-08	0.008291	5.06473e-08	11	150									
EIF2C2	27161	broad.mit.edu	37	8	141549523	141549523	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr8:141549523C>A	uc003yvn.2	-	16	2105	c.2065G>T	c.(2065-2067)GAG>TAG	p.E689*	EIF2C2_uc010men.2_Nonsense_Mutation_p.E612*|EIF2C2_uc010meo.2_Nonsense_Mutation_p.E689*	NM_012154	NP_036286	Q9UKV8	AGO2_HUMAN	argonaute 2 isoform 1	689	Piwi.				mRNA cleavage involved in gene silencing by miRNA|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|pre-miRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|mRNA cap binding complex|nucleus|polysome|RNA-induced silencing complex	endoribonuclease activity, cleaving siRNA-paired mRNA|metal ion binding|protein binding|RNA 7-methylguanosine cap binding|siRNA binding|translation initiation factor activity				0	all_cancers(97;2.54e-14)|all_epithelial(106;5.99e-13)|Lung NSC(106;1.45e-05)|all_lung(105;2.07e-05)|Ovarian(258;0.0154)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.158)			ATACAGGCCTCACGGATGGCC	0.567		NaN											1	0	2.17888e-05	0.006214	2.30841e-05	6	111									
C9orf46	55848	broad.mit.edu	37	9	5358254	5358254	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr9:5358254G>C	uc003zjc.2	-	6	633	c.429C>G	c.(427-429)TTC>TTG	p.F143L	C9orf46_uc003zjd.2_Missense_Mutation_p.F143L	NM_018465	NP_060935	Q9HBL7	CI046_HUMAN	hypothetical protein LOC55848	143						integral to membrane				ovary(1)	1	all_hematologic(13;0.158)	Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.00106)|Lung(218;0.125)		TGTCTATGAAGAATCTACTCT	0.338		NaN											0	0	0	0.004482	0	6	112									
CNTLN	54875	broad.mit.edu	37	9	17457539	17457539	+	Silent	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr9:17457539G>A	uc003zmz.2	+	19	3155	c.3129G>A	c.(3127-3129)TTG>TTA	p.L1043L	CNTLN_uc003zmy.2_Silent_p.L1044L|CNTLN_uc010mio.2_Silent_p.L723L	NM_017738	NP_060208	Q9NXG0	CNTLN_HUMAN	centlein isoform 1	1044	Potential.					centriole|membrane	two-component sensor activity			pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.14e-10)		ATTTGGATTTGGCTGGGCTTC	0.254		NaN											0	0	0	0.000602	0	4	62									
ADAMTSL1	92949	broad.mit.edu	37	9	18776929	18776929	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr9:18776929C>T	uc003zne.3	+	19	2829	c.2702C>T	c.(2701-2703)GCG>GTG	p.A901V		NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	901	Ig-like C2-type 1.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		CGCTGCCCGGCGCGCAGGGTC	0.652		NaN											0	0	0	0.009096	0	4	39									
DDX58	23586	broad.mit.edu	37	9	32500809	32500809	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr9:32500809G>A	uc003zra.2	-	2	393	c.235C>T	c.(235-237)CAT>TAT	p.H79Y	DDX58_uc010mjj.2_RNA|DDX58_uc010mjk.1_Intron|DDX58_uc011lnr.1_5'UTR|DDX58_uc010mji.2_5'UTR	NM_014314	NP_055129	O95786	DDX58_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide	79	CARD 1.				detection of virus|innate immune response|negative regulation of type I interferon production|positive regulation of defense response to virus by host|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter	cytosol	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|protein binding|zinc ion binding			ovary(2)|liver(1)|pancreas(1)	4			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;0.00056)		TAACCTGCATGGTCTAGGGCA	0.418		NaN											0	0	0	0.001984	0	6	114									
FRMD3	257019	broad.mit.edu	37	9	86004545	86004545	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr9:86004545G>A	uc004ams.1	-	2	428	c.226C>T	c.(226-228)CGC>TGC	p.R76C	FRMD3_uc004amr.1_Missense_Mutation_p.R62C	NM_174938	NP_777598	A2A2Y4	FRMD3_HUMAN	FERM domain containing 3	76	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			ovary(1)|central_nervous_system(1)	2						TCCACATAGCGAATGCCAAAG	0.498		NaN											0	0	0	0.00308	0	5	95									
NTRK2	4915	broad.mit.edu	37	9	87338522	87338522	+	Silent	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr9:87338522C>T	uc004aoa.1	+	9	1556	c.618C>T	c.(616-618)CTC>CTT	p.L206L	NTRK2_uc004anv.1_Silent_p.L206L|NTRK2_uc004any.1_Silent_p.L206L|NTRK2_uc004anz.1_Silent_p.L206L|NTRK2_uc011lsz.1_Silent_p.L206L|NTRK2_uc011lta.1_Silent_p.L206L|NTRK2_uc004aob.1_Silent_p.L206L|NTRK2_uc011ltb.1_Silent_p.L50L	NM_001018064	NP_001018074	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	206	Extracellular (Potential).|Ig-like C2-type 1.				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			lung(11)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|liver(1)	16						CACCTAACCTCACTGTGGAGG	0.408		NaN								TSP Lung(25;0.17)			0	0	0	0.004482	0	7	73									
TMEFF1	8577	broad.mit.edu	37	9	103312381	103312381	+	Silent	SNP	A	A	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr9:103312381A>T	uc004baz.1	+	7	824	c.714A>T	c.(712-714)ACA>ACT	p.T238T	TMEFF1_uc004bay.1_Silent_p.T312T	NM_003692	NP_003683	Q8IYR6	TEFF1_HUMAN	transmembrane protein with EGF-like and two	238	Extracellular (Potential).				multicellular organismal development	integral to membrane|plasma membrane					0		Acute lymphoblastic leukemia(62;0.0452)				TTACAGATACAGATGACACTA	0.343		NaN											0	0	0	0.001168	0	6	75									
SMC2	10592	broad.mit.edu	37	9	106894344	106894344	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr9:106894344C>T	uc004bbv.2	+	22	3334	c.3046C>T	c.(3046-3048)CTT>TTT	p.L1016F	SMC2_uc004bbw.2_Missense_Mutation_p.L1016F|SMC2_uc011lvl.1_Missense_Mutation_p.L1016F|SMC2_uc004bbx.2_Missense_Mutation_p.L1016F|SMC2_uc004bby.2_RNA	NM_001042551	NP_001036016	O95347	SMC2_HUMAN	structural maintenance of chromosomes 2	1016	Potential.				cell division|mitotic chromosome condensation|symbiosis, encompassing mutualism through parasitism	condensin complex|cytoplasm|nuclear chromosome	ATP binding|protein heterodimerization activity			ovary(4)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|breast(1)	9						ATCCAAAATTCTTACAACTAT	0.308		NaN											0	0	0	0.009096	0	4	34									
GAPVD1	26130	broad.mit.edu	37	9	128088742	128088742	+	Missense_Mutation	SNP	C	C	T	rs144122272	by1000genomes	TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr9:128088742C>T	uc010mwx.2	+	12	2232	c.1906C>T	c.(1906-1908)CGT>TGT	p.R636C	GAPVD1_uc011lzs.1_Missense_Mutation_p.R636C|GAPVD1_uc004bpp.2_Missense_Mutation_p.R636C|GAPVD1_uc004bpq.2_Missense_Mutation_p.R636C|GAPVD1_uc004bpr.2_Missense_Mutation_p.R615C|GAPVD1_uc004bps.2_Missense_Mutation_p.R636C|GAPVD1_uc010mwy.1_Missense_Mutation_p.R495C	NM_015635	NP_056450	Q14C86	GAPD1_HUMAN	GTPase activating protein and VPS9 domains 1	636					endocytosis|regulation of protein transport|regulation of small GTPase mediated signal transduction|signal transduction	cytosol|endosome|membrane	GTPase activating protein binding|GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						GTTTGAAATTCGTGACATGAT	0.368		NaN											0	0	0	0.001168	0	5	89									
DOLPP1	57171	broad.mit.edu	37	9	131843433	131843433	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr9:131843433C>G	uc004bxc.2	+	1	51	c.23C>G	c.(22-24)TCG>TGG	p.S8W	DOLPP1_uc004bxd.2_Missense_Mutation_p.S8W|DOLPP1_uc004bxe.2_RNA	NM_020438	NP_065171	Q86YN1	DOPP1_HUMAN	dolichyl pyrophosphate phosphatase 1 isoform a	8					dolichyl diphosphate biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to endoplasmic reticulum membrane	dolichyldiphosphatase activity			skin(1)	1						GGACAGTGCTCGCTCCCCGCT	0.672		NaN											0	0	0	0.00499	0	11	91									
ABL1	25	broad.mit.edu	37	9	133759972	133759972	+	Silent	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr9:133759972G>A	uc004bzw.2	+	11	2298	c.2295G>A	c.(2293-2295)AAG>AAA	p.K765K	ABL1_uc004bzv.2_Silent_p.K784K	NM_005157	NP_005148	P00519	ABL1_HUMAN	c-abl oncogene 1, receptor tyrosine kinase	765	Nuclear localization signal 3 (Potential).				actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			haematopoietic_and_lymphoid_tissue(807)|lung(5)|stomach(2)|central_nervous_system(1)|breast(1)|skin(1)	817		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	TGCCTCGGAAGAGGGCAGGGG	0.582		NaN	T|Mis	BCR|ETV6|NUP214	CML|ALL|T-ALL								0	0	0	0.00308	0	5	60									
BAT2L1	84726	broad.mit.edu	37	9	134351676	134351676	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr9:134351676G>A	uc004can.3	+	15	4215	c.4160G>A	c.(4159-4161)CGG>CAG	p.R1387Q	BAT2L1_uc010mzj.1_Missense_Mutation_p.R970Q|BAT2L1_uc004cao.3_Missense_Mutation_p.R745Q	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	HLA-B associated transcript 2-like	1387							protein binding				0						AGCGAGCGGCGGGAGCGGCGG	0.667		NaN									OREG0019561	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004672	0	2	2									
FRMPD4	9758	broad.mit.edu	37	X	12724949	12724949	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:12724949C>G	uc004cuz.1	+	12	1708	c.1202C>G	c.(1201-1203)TCT>TGT	p.S401C	FRMPD4_uc011mij.1_Missense_Mutation_p.S393C	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	401	FERM.				positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						CCTCAGCTCTCTGCACTACAA	0.428		NaN											0	0	0	0.004007	0	10	138									
ZRSR2	8233	broad.mit.edu	37	X	15818001	15818001	+	Nonsense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:15818001C>G	uc004cxg.3	+	3	173	c.128C>G	c.(127-129)TCA>TGA	p.S43*		NM_005089	NP_005080	Q15696	U2AFM_HUMAN	U2 small nuclear RNA auxiliary factor 1-like 2	43					spliceosome assembly	U12-type spliceosomal complex	nucleotide binding|pre-mRNA 3'-splice site binding|protein binding|zinc ion binding			breast(3)	3	Hepatocellular(33;0.183)					CTAGGACTCTCACAGAAGGAG	0.328		NaN											0	0	0	0.000602	0	5	66									
CTPS2	56474	broad.mit.edu	37	X	16707722	16707722	+	Silent	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:16707722G>A	uc004cxk.2	-	8	1467	c.723C>T	c.(721-723)GTC>GTT	p.V241V	CTPS2_uc004cxl.2_Silent_p.V241V|CTPS2_uc004cxm.2_Silent_p.V241V	NM_001144002	NP_001137474	Q9NRF8	PYRG2_HUMAN	cytidine triphosphate synthase II	241					glutamine metabolic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine nucleotide biosynthetic process	cytosol	ATP binding|CTP synthase activity			ovary(1)	1	Hepatocellular(33;0.0997)					GGATACATATGACCTAAGTGG	0.388		NaN											0	0	0	0.004482	0	8	123									
PPEF1	5475	broad.mit.edu	37	X	18822166	18822166	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:18822166G>A	uc004cyq.2	+	14	1703	c.1222G>A	c.(1222-1224)GAA>AAA	p.E408K	PPEF1_uc004cyp.2_Missense_Mutation_p.E380K|PPEF1_uc004cyr.2_Intron|PPEF1_uc004cys.2_Missense_Mutation_p.E408K|PPEF1_uc011mja.1_Missense_Mutation_p.E343K|PPEF1_uc011mjb.1_Missense_Mutation_p.E352K	NM_006240	NP_006231	O14829	PPE1_HUMAN	protein phosphatase with EF hand calcium-binding	408	Catalytic.				detection of stimulus involved in sensory perception|protein dephosphorylation		calcium ion binding|iron ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity				0	Hepatocellular(33;0.183)					ATGTAAGCCCGAAGGGTATGA	0.433		NaN											0	0	0	0.000978	0	8	99									
SH3KBP1	30011	broad.mit.edu	37	X	19764521	19764521	+	Silent	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:19764521G>A	uc004czm.2	-	3	517	c.201C>T	c.(199-201)AAC>AAT	p.N67N	SH3KBP1_uc004czl.2_Silent_p.N30N	NM_031892	NP_114098	Q96B97	SH3K1_HUMAN	SH3-domain kinase binding protein 1 isoform a	67					apoptosis|cell-cell signaling|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytoplasmic vesicle membrane|cytoskeleton|cytosol|focal adhesion|nucleus|synapse|synaptosome	SH3 domain binding				0						CTGGAGCTTTGTTGGTGAGAG	0.398		NaN											0	0	0	0.008871	0	16	139									
DMD	1756	broad.mit.edu	37	X	32328262	32328262	+	Silent	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:32328262G>C	uc004dda.1	-	42	6298	c.6054C>G	c.(6052-6054)CTC>CTG	p.L2018L	DMD_uc004dcw.2_Silent_p.L674L|DMD_uc004dcx.2_Silent_p.L677L|DMD_uc004dcz.2_Silent_p.L1895L|DMD_uc004dcy.1_Silent_p.L2014L|DMD_uc004ddb.1_Silent_p.L2010L|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2018	Spectrin 14.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CAGGAGCATTGAGAAGTTGTT	0.393		NaN											0	0	0	0.001984	0	5	83									
SSX3	10214	broad.mit.edu	37	X	48214125	48214125	+	Silent	SNP	G	G	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:48214125G>C	uc004djd.1	-	3	220	c.126C>G	c.(124-126)GTC>GTG	p.V42V	SSX3_uc004dje.2_Silent_p.V42V|SSX3_uc010nic.2_Silent_p.V42V	NM_021014	NP_066294	Q99909	SSX3_HUMAN	synovial sarcoma, X breakpoint 3 isoform a	42	KRAB-related.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding				0						TTTTCTCCGAGACTTTCATCT	0.398		NaN											0	0	0	0.006214	0	9	127									
GRIPAP1	56850	broad.mit.edu	37	X	48855860	48855860	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:48855860C>G	uc004dly.1	-	2	134	c.99G>C	c.(97-99)AAG>AAC	p.K33N	GRIPAP1_uc004dma.2_Missense_Mutation_p.K33N	NM_020137	NP_064522	Q4V328	GRAP1_HUMAN	GRIP1 associated protein 1 isoform 1	33	Potential.					early endosome				breast(2)|kidney(1)	3						CAACACCATTCTTGCGTAGTT	0.552		NaN											0	0	0	0.001984	0	4	67									
ITIH5L	347365	broad.mit.edu	37	X	54784222	54784222	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:54784222G>A	uc004dtj.2	-	8	2315	c.2285C>T	c.(2284-2286)CCT>CTT	p.P762L		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	762	Pro-rich.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						AGGTTTCACAGGTGGGACTTG	0.532		NaN											0	0	0	0.00308	0	7	97									
VSIG4	11326	broad.mit.edu	37	X	65253645	65253645	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:65253645C>G	uc004dwh.2	-	2	210	c.83G>C	c.(82-84)AGT>ACT	p.S28T	VSIG4_uc004dwi.2_Missense_Mutation_p.S28T|VSIG4_uc010nkq.1_Missense_Mutation_p.S28T|VSIG4_uc004dwj.2_Missense_Mutation_p.S28T|VSIG4_uc011moy.1_Missense_Mutation_p.S28T|VSIG4_uc004dwk.2_Missense_Mutation_p.S28T|VSIG4_uc004dwl.2_5'UTR	NM_007268	NP_009199	Q9Y279	VSIG4_HUMAN	V-set and immunoglobulin domain containing 4	28	Ig-like 1.|Extracellular (Potential).				complement activation, alternative pathway	integral to membrane	protein binding				0						TCCTGTTACACTCTCTGGCAC	0.532		NaN											0	0	0	0.006214	0	7	96									
MAGEE2	139599	broad.mit.edu	37	X	75004685	75004685	+	Missense_Mutation	SNP	G	G	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:75004685G>T	uc004ecj.1	-	1	387	c.202C>A	c.(202-204)CTG>ATG	p.L68M		NM_138703	NP_619648	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	68										ovary(1)|skin(1)	2						AGGACCTCCAGGTCATTCGGG	0.567		NaN											1	0	0.00024832	0.009096	0.000257078	4	71									
LPAR4	2846	broad.mit.edu	37	X	78010591	78010591	+	Silent	SNP	T	T	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:78010591T>A	uc010nme.2	+	2	630	c.225T>A	c.(223-225)GCT>GCA	p.A75A		NM_005296	NP_005287	Q99677	LPAR4_HUMAN	lysophosphatidic acid receptor 4	75	Helical; Name=2; (Potential).					integral to plasma membrane	lipid binding|purinergic nucleotide receptor activity, G-protein coupled			ovary(3)	3						GTGAGACTGCTATTTTTATCA	0.393		NaN											0	0	0	0.008291	0	10	209									
LPAR4	2846	broad.mit.edu	37	X	78010794	78010794	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:78010794C>G	uc010nme.2	+	2	833	c.428C>G	c.(427-429)CCT>CGT	p.P143R		NM_005296	NP_005287	Q99677	LPAR4_HUMAN	lysophosphatidic acid receptor 4	143	Cytoplasmic (Potential).					integral to plasma membrane	lipid binding|purinergic nucleotide receptor activity, G-protein coupled			ovary(3)	3						ATTGTCTATCCTTTTCGATCT	0.463		NaN											0	0	0	0.001168	0	5	122									
XKRX	402415	broad.mit.edu	37	X	100169786	100169786	+	Missense_Mutation	SNP	A	A	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:100169786A>T	uc004egn.2	-	3	1496	c.891T>A	c.(889-891)AAT>AAA	p.N297K	XKRX_uc011mre.1_Missense_Mutation_p.N93K	NM_212559	NP_997724	Q6PP77	XKR2_HUMAN	XK, Kell blood group complex subunit-related,	297						integral to membrane|plasma membrane				breast(1)	1						TCTCAATGTTATTGGGCATCT	0.493		NaN											0	0	0	0.008291	0	9	162									
BTK	695	broad.mit.edu	37	X	100617172	100617172	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:100617172C>T	uc004ehg.2	-	7	770	c.577G>A	c.(577-579)GAG>AAG	p.E193K	BTK_uc010nnn.2_Missense_Mutation_p.E193K|BTK_uc010nno.2_Missense_Mutation_p.E227K|BTK_uc004ehi.2_Missense_Mutation_p.E193K	NM_000061	NP_000052	Q06187	BTK_HUMAN	Bruton agammaglobulinemia tyrosine kinase	193					calcium-mediated signaling|induction of apoptosis by extracellular signals|mesoderm development	cytosol|membrane raft|nucleus|plasma membrane	ATP binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol-3,4,5-trisphosphate binding			lung(3)|central_nervous_system(2)|ovary(1)	6						TGGTCCTCCTCAGGCGTTGGG	0.468		NaN							Agammaglobulinemia_X-linked				0	0	0	0.004482	0	7	116									
RNF128	79589	broad.mit.edu	37	X	105970542	105970542	+	Silent	SNP	T	T	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:105970542T>C	uc004eml.2	+	1	649	c.399T>C	c.(397-399)CAT>CAC	p.H133H	RNF128_uc004emk.2_Intron	NM_194463	NP_919445	Q8TEB7	RN128_HUMAN	ring finger protein 128 isoform 1	133	PA.					endomembrane system|integral to membrane|perinuclear region of cytoplasm	zinc ion binding			ovary(1)|central_nervous_system(1)	2						ACAAGATCCATCTGGCTTATG	0.597		NaN											0	0	0	0.00308	0	6	78									
ALG13	79868	broad.mit.edu	37	X	110970869	110970869	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:110970869G>A	uc011msy.1	+	18	2152	c.2118G>A	c.(2116-2118)ATG>ATA	p.M706I	ALG13_uc011msx.1_Missense_Mutation_p.M602I|ALG13_uc011msz.1_Missense_Mutation_p.M628I|ALG13_uc011mta.1_Missense_Mutation_p.M602I|ALG13_uc011mtb.1_Missense_Mutation_p.M602I			Q9NP73	ALG13_HUMAN	SubName: Full=Asparagine-linked glycosylation 13 homolog (S. cerevisiae);	706					dolichol-linked oligosaccharide biosynthetic process|lipid glycosylation|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane	carbohydrate binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity			lung(1)	1						ACCGCCAGATGAGTTGTGTGA	0.358		NaN											0	0	0	0.009096	0	3	25									
KIAA1210	57481	broad.mit.edu	37	X	118284333	118284333	+	Silent	SNP	T	T	C			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:118284333T>C	uc004era.3	-	1	210	c.210A>G	c.(208-210)GCA>GCG	p.A70A		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	70										ovary(4)|skin(1)	5						GGTCAGTCACTGCAGCTGGGC	0.547		NaN											0	0	0	0.009096	0	3	20									
UPF3B	65109	broad.mit.edu	37	X	118977197	118977197	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:118977197C>G	uc004erz.1	-	5	614	c.537G>C	c.(535-537)GAG>GAC	p.E179D	UPF3B_uc004esa.1_Missense_Mutation_p.E179D	NM_080632	NP_542199	Q9BZI7	REN3B_HUMAN	UPF3 regulator of nonsense transcripts homolog B	179	Sufficient for association with EJC core.|Necessary for interaction with UPF2.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|termination of RNA polymerase II transcription	cytosol|exon-exon junction complex|nucleoplasm	mRNA binding|nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(2)|kidney(1)	3						CTAGCAGTGTCTCTGGAGTAG	0.328		NaN											0	0	0	0.008291	0	7	154									
CUL4B	8450	broad.mit.edu	37	X	119670883	119670883	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:119670883G>A	uc004esw.2	-	17	2436	c.1999C>T	c.(1999-2001)CAG>TAG	p.Q667*	CUL4B_uc010nqq.2_Nonsense_Mutation_p.Q368*|CUL4B_uc004esv.2_Nonsense_Mutation_p.Q649*	NM_003588	NP_003579	Q13620	CUL4B_HUMAN	cullin 4B isoform 1	667					cell cycle|DNA repair|ubiquitin-dependent protein catabolic process	Cul4B-RING ubiquitin ligase complex|nucleus	protein binding|ubiquitin protein ligase binding			lung(1)|central_nervous_system(1)|pancreas(1)	3						TTCTGATTCTGCATATACTAT	0.348		NaN											0	0	0	0.001855	0	11	105									
DCAF12L2	340578	broad.mit.edu	37	X	125299261	125299261	+	Missense_Mutation	SNP	G	G	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:125299261G>T	uc004euk.1	-	1	674	c.647C>A	c.(646-648)ACC>AAC	p.T216N		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	216	WD 2.									lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						CAGAGCCACGGTGCCGTCGCG	0.637		NaN											1	0	7.07596e-05	0.006122	7.41786e-05	15	76									
ATP2B3	492	broad.mit.edu	37	X	152821836	152821836	+	Silent	SNP	G	G	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:152821836G>A	uc004fht.1	+	13	2412	c.2286G>A	c.(2284-2286)CTG>CTA	p.L762L	ATP2B3_uc004fhs.1_Silent_p.L762L	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	762	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TGAGGGTGCTGGCCCGGTCGT	0.652		NaN											0	0	0	0.004672	0	3	24									
HCFC1	3054	broad.mit.edu	37	X	153224215	153224215	+	Silent	SNP	C	C	A			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:153224215C>A	uc004fjp.2	-	10	2136	c.1608G>T	c.(1606-1608)GTG>GTT	p.V536V		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	536					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TACTGCCAATCACCTGCAGCA	0.677		NaN											1	0	0.00909568	0.009096	0.00928169	3	23									
FLNA	2316	broad.mit.edu	37	X	153596245	153596245	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:153596245C>T	uc004fkk.2	-	3	836	c.587G>A	c.(586-588)CGG>CAG	p.R196Q	FLNA_uc010nuu.1_Missense_Mutation_p.R196Q	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	196	CH 2.|Actin-binding.		R -> W (in OPD1).|R -> G (in OPD2).		actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCCCAGGGCCCGGCCGCTCTG	0.692		NaN											0	0	0	0.006214	0	7	54									
ELF3	1999	broad.mit.edu	37	1	201980309	201980309	+	Frame_Shift_Del	DEL	C	C	-			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08			C	-	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:201980309delC	uc001gxg.3	+	1	3237	c.45delC	c.(43-45)TTCfs	p.F15fs	ELF3_uc001gxi.3_Frame_Shift_Del_p.F15fs|ELF3_uc001gxh.3_Frame_Shift_Del_p.F15fs	NM_004433	NP_004424	P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription	15					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0						GCAACTACTTCAGTGCGATGT	0.577		NaN											NaN	NaN	NaN	NaN	NaN	54	249	---	---							
CCDC83	220047	broad.mit.edu	37	11	85627263	85627265	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:85627263_85627265delAGA	uc001pbh.1	+	10	1579_1581	c.1067_1069delAGA	c.(1066-1071)GAGAAG>GAG	p.K357del	CCDC83_uc001pbg.1_In_Frame_Del_p.K388del|CCDC83_uc001pbi.1_RNA|CCDC83_uc001pbj.1_In_Frame_Del_p.K257del	NM_173556	NP_775827	Q8IWF9	CCD83_HUMAN	coiled-coil domain containing 83	357										skin(1)	1		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				TATGAGGATGAGAAGGATTTCAA	0.335		NaN											NaN	NaN	NaN	NaN	NaN	12	127	---	---							
NOX4	50507	broad.mit.edu	37	11	89106662	89106663	+	Splice_Site	INS	-	-	A	rs56022003		TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:89106662_89106663insA	uc001pct.2	-	12	1314	c.1075_splice	c.e12-1	p.C359_splice	NOX4_uc009yvr.2_Splice_Site_p.C334_splice|NOX4_uc001pcu.2_Splice_Site_p.C285_splice|NOX4_uc001pcw.2_Splice_Site_p.C52_splice|NOX4_uc001pcx.2_Splice_Site_p.C52_splice|NOX4_uc001pcv.2_Splice_Site_p.C359_splice|NOX4_uc009yvo.2_Splice_Site|NOX4_uc010rtu.1_Splice_Site_p.C193_splice|NOX4_uc009yvp.2_Intron|NOX4_uc010rtv.1_Splice_Site_p.C335_splice|NOX4_uc009yvq.2_Splice_Site_p.C335_splice	NM_016931	NP_058627	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4 isoform a						cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				AGTTGGACACTAAAAAAAAATA	0.292		NaN											NaN	NaN	NaN	NaN	NaN	9	180	---	---							
LINS1	55180	broad.mit.edu	37	15	101109865	101109866	+	Frame_Shift_Del	DEL	AC	AC	-	rs146405261	byFrequency	TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr15:101109865_101109866delAC	uc002bwe.2	-	8	2142_2143	c.1851_1852delGT	c.(1849-1854)CTGTCTfs	p.L617fs	LINS1_uc002bwd.2_Frame_Shift_Del_p.L204fs|LINS1_uc002bwf.2_Frame_Shift_Del_p.L617fs|LINS1_uc002bwg.2_Frame_Shift_Del_p.L617fs|LINS1_uc002bwh.2_Frame_Shift_Del_p.L617fs	NM_001040614	NP_001035704	Q8NG48	LINES_HUMAN	lines homolog 1	617_618											0	Lung NSC(78;0.0018)|all_lung(78;0.00223)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.00095)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)			CGGGGGGAAGACAGACTAGAAG	0.53		NaN											NaN	NaN	NaN	NaN	NaN	7	95	---	---							
CCR7	1236	broad.mit.edu	37	17	38711926	38711927	+	Frame_Shift_Del	DEL	AA	AA	-			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:38711926_38711927delAA	uc002huw.2	-	3	267_268	c.204_205delTT	c.(202-207)ATTTGTfs	p.I68fs		NM_001838	NP_001829	P32248	CCR7_HUMAN	chemokine (C-C motif) receptor 7 precursor	68_69	Helical; Name=1; (Potential).				cell maturation|immunological synapse formation|inflammatory response|interleukin-12 secretion|lymphocyte migration into lymph node|positive regulation of dendritic cell antigen processing and presentation|positive regulation of glycoprotein biosynthetic process|positive regulation of humoral immune response|positive regulation of hypersensitivity|positive regulation of interleukin-12 production|positive regulation of neutrophil chemotaxis|regulation of interferon-gamma production|regulation of interleukin-1 beta secretion|T cell costimulation	integral to membrane|intracellular	C-C chemokine receptor activity|chemokine (C-C motif) ligand 19 binding|chemokine (C-C motif) ligand 21 binding			breast(1)	1		Breast(137;0.000496)				CCCACGAAACAAATGATGGAGT	0.495		NaN											NaN	NaN	NaN	NaN	NaN	10	105	---	---							
TOB1	10140	broad.mit.edu	37	17	48941203	48941206	+	Frame_Shift_Del	DEL	TGTA	TGTA	-			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:48941203_48941206delTGTA	uc002isw.2	-	1	208_211	c.173_176delTACA	c.(172-177)ATACACfs	p.I58fs	TOB1_uc010wmy.1_Frame_Shift_Del_p.I58fs|TOB1_uc010wmz.1_Frame_Shift_Del_p.I58fs|uc002isy.2_5'Flank	NM_005749	NP_005740	P50616	TOB1_HUMAN	transducer of ERBB2, 1	58_59					negative regulation of cell proliferation		SH3/SH2 adaptor activity			large_intestine(1)	1			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			CTCCCCTATGTGTATACATCTAAA	0.417		NaN											NaN	NaN	NaN	NaN	NaN	24	322	---	---							
SNRPB	6628	broad.mit.edu	37	20	2443773	2443773	+	Frame_Shift_Del	DEL	C	C	-			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr20:2443773delC	uc002wfz.1	-	5	684	c.521delG	c.(520-522)GGTfs	p.G174fs	SNRPB_uc002wga.1_Frame_Shift_Del_p.G174fs|SNRPB_uc010zpv.1_Frame_Shift_Del_p.G95fs|SNRPB_uc002wgb.2_Frame_Shift_Del_p.G174fs|SNORD119_uc010gam.1_5'Flank	NM_198216	NP_937859	P14678	RSMB_HUMAN	small nuclear ribonucleoprotein polypeptide B/B'	174					histone mRNA metabolic process|ncRNA metabolic process|spliceosomal snRNP assembly|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nucleoplasm|U12-type spliceosomal complex|U7 snRNP	protein binding|protein binding|RNA binding			ovary(1)	1						TGGGGGAGGACCCCCACGGCC	0.592		NaN											NaN	NaN	NaN	NaN	NaN	12	252	---	---							
DGCR8	54487	broad.mit.edu	37	22	20082278	20082279	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr22:20082278_20082279delAG	uc002zri.2	+	9	2098_2099	c.1748_1749delAG	c.(1747-1749)CAGfs	p.Q583fs	DGCR8_uc010grz.2_Frame_Shift_Del_p.Q550fs|DGCR8_uc002zrj.2_Frame_Shift_Del_p.Q226fs	NM_022720	NP_073557	Q8WYQ5	DGCR8_HUMAN	DiGeorge syndrome critical region gene 8	583	Necessary for heme-binding and pri-miRNA processing.|Necessary for interaction with DROSHA.				primary miRNA processing	cytoplasm|cytoplasm|microtubule cytoskeleton|nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding				0	Colorectal(54;0.0993)					TTTGTTAAACAGACCTCTGAAG	0.55		NaN											NaN	NaN	NaN	NaN	NaN	13	184	---	---							
ALAS1	211	broad.mit.edu	37	3	52237973	52237978	+	In_Frame_Del	DEL	GCAAAA	GCAAAA	-			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:52237973_52237978delGCAAAA	uc003dcy.1	+	5	859_864	c.522_527delGCAAAA	c.(520-528)ATGCAAAAG>ATG	p.QK175del	ALAS1_uc003dcz.1_In_Frame_Del_p.QK175del|ALAS1_uc011bec.1_In_Frame_Del_p.QK192del	NM_000688	NP_000679	P13196	HEM1_HUMAN	5-aminolevulinate synthase 1 precursor	175_176					heme biosynthetic process	mitochondrial matrix	5-aminolevulinate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(2)|upper_aerodigestive_tract(1)	3				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.000583)|KIRC - Kidney renal clear cell carcinoma(197;0.000751)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	AGGACATCATGCAAAAGCAAAGACCA	0.422		NaN											NaN	NaN	NaN	NaN	NaN	15	133	---	---							
SUN1	23353	broad.mit.edu	37	7	896032	896032	+	Frame_Shift_Del	DEL	C	C	-			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:896032delC	uc011jvp.1	+	13	1467	c.1388delC	c.(1387-1389)ACAfs	p.T463fs	GET4_uc003sjj.1_RNA|SUN1_uc003sjf.2_Frame_Shift_Del_p.T380fs|SUN1_uc011jvq.1_Frame_Shift_Del_p.T360fs|SUN1_uc003sjg.2_Frame_Shift_Del_p.T368fs|SUN1_uc011jvr.1_Frame_Shift_Del_p.T261fs|SUN1_uc003sji.2_Frame_Shift_Del_p.T301fs|SUN1_uc003sjk.2_Frame_Shift_Del_p.T102fs	NM_001130965	NP_001124437	O94901	SUN1_HUMAN	unc-84 homolog A isoform a	490	Perinuclear space.|Potential.				cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane	integral to membrane|nuclear inner membrane|SUN-KASH complex	protein binding				0						AAGCAAAAAACAATCAGGTAG	0.418		NaN											NaN	NaN	NaN	NaN	NaN	11	121	---	---							
SFRP1	6422	broad.mit.edu	37	8	41166638	41166640	+	In_Frame_Del	DEL	GCT	GCT	-	rs3055861		TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr8:41166638_41166640delGCT	uc003xnt.2	-	1	341_343	c.39_41delAGC	c.(37-42)GCAGCC>GCC	p.13_14AA>A		NM_003012	NP_003003	Q8N474	SFRP1_HUMAN	secreted frizzled-related protein 1 precursor	13_14				Missing (in Ref. 1 and 3).	brain development|canonical Wnt receptor signaling pathway|cellular response to BMP stimulus|cellular response to estradiol stimulus|cellular response to fibroblast growth factor stimulus|cellular response to heparin|cellular response to hypoxia|cellular response to interleukin-1|cellular response to prostaglandin E stimulus|cellular response to starvation|cellular response to transforming growth factor beta stimulus|cellular response to tumor necrosis factor|cellular response to vitamin D|DNA fragmentation involved in apoptotic nuclear change|dorsal/ventral axis specification|hemopoietic progenitor cell differentiation|hemopoietic stem cell differentiation|menstrual cycle phase|negative regulation of androgen receptor signaling pathway|negative regulation of B cell differentiation|negative regulation of bone remodeling|negative regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cysteine-type endopeptidase activity|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast apoptosis|negative regulation of fibroblast proliferation|negative regulation of insulin secretion|negative regulation of ossification|negative regulation of osteoblast proliferation|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|osteoblast differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell growth|positive regulation of epithelial cell proliferation|positive regulation of fat cell differentiation|positive regulation of fibroblast apoptosis|positive regulation of focal adhesion assembly|positive regulation of non-canonical Wnt receptor signaling pathway|positive regulation of Rac GTPase activity|positive regulation of smoothened signaling pathway|positive regulation of stress fiber assembly|positive regulation of transcription, DNA-dependent|regulation of angiogenesis|regulation of cell cycle process|response to drug|response to organic cyclic compound|vasculature development	cell surface|cytosol|extracellular space|plasma membrane|proteinaceous extracellular matrix	cysteine-type endopeptidase activity|drug binding|frizzled binding|heparin binding|identical protein binding|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)	1	Breast(1;9.19e-13)|Ovarian(28;0.00769)|Colorectal(14;0.0305)|Lung SC(25;0.211)	all_lung(54;0.0034)|Lung NSC(58;0.0134)|Hepatocellular(245;0.023)|Esophageal squamous(32;0.0559)	BRCA - Breast invasive adenocarcinoma(1;1.11e-10)|LUSC - Lung squamous cell carcinoma(45;0.00894)|COAD - Colon adenocarcinoma(11;0.0174)			CACGCCCAGGGCTGCCCCGCGGC	0.764		NaN											NaN	NaN	NaN	NaN	NaN	7	3	---	---							
ROR2	4920	broad.mit.edu	37	9	94486026	94486028	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr9:94486026_94486028delTCC	uc004arj.1	-	9	2947_2949	c.2748_2750delGGA	c.(2746-2751)GAGGAA>GAA	p.916_917EE>E	ROR2_uc004ari.1_Intron	NM_004560	NP_004551	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	916_917	Cytoplasmic (Potential).				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			lung(8)|central_nervous_system(5)|ovary(3)|large_intestine(2)|stomach(1)|breast(1)	20						GACAGAGCCTTCCTCCTCCTCCT	0.645		NaN											NaN	NaN	NaN	NaN	NaN	8	145	---	---							
POLA1	5422	broad.mit.edu	37	X	24755805	24755805	+	Frame_Shift_Del	DEL	C	C	-			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:24755805delC	uc004dbl.2	+	19	1992	c.1969delC	c.(1969-1971)CCTfs	p.P657fs		NM_016937	NP_058633	P09884	DPOLA_HUMAN	DNA-directed DNA polymerase alpha 1	657	Potential.				cell proliferation|DNA replication checkpoint|DNA replication, synthesis of RNA primer|DNA-dependent DNA replication initiation|double-strand break repair via nonhomologous end joining|interspecies interaction between organisms|lagging strand elongation|leading strand elongation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|cytoplasm|nuclear envelope|nuclear matrix|nucleolus|nucleoplasm	chromatin binding|DNA-directed DNA polymerase activity|metal ion binding|nucleoside binding			ovary(2)|skin(1)	3					Clofarabine(DB00631)|Fludarabine(DB01073)	GTGCAAAGCTCCTCACTGGTC	0.338		NaN											NaN	NaN	NaN	NaN	NaN	11	202	---	---