Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
SCNN1D	6339	broad.mit.edu	37	1	1222339	1222339	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr1:1222339G>C	uc001adu.1	+	7	1235	c.611G>C	c.(610-612)AGA>ACA	p.R204T	SCNN1D_uc001adt.1_Missense_Mutation_p.R368T|SCNN1D_uc001adw.2_Missense_Mutation_p.R270T|SCNN1D_uc001adx.2_5'UTR|SCNN1D_uc001adv.2_Missense_Mutation_p.R204T	NM_002978	NP_002969			sodium channel, nonvoltage-gated 1, delta												0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;2.46e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		AGCCGGGTCAGAGTGGGGTTC	0.701		NaN											0	0	0	0.175082	0	19	18									
PLEKHM2	23207	broad.mit.edu	37	1	16053704	16053704	+	Silent	SNP	G	G	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr1:16053704G>A	uc010obo.1	+	9	1364	c.1137G>A	c.(1135-1137)CCG>CCA	p.P379P		NM_015164	NP_055979	Q8IWE5	PKHM2_HUMAN	pleckstrin homology domain containing, family M	379					Golgi organization	cytoplasm	kinesin binding			ovary(1)	1		Colorectal(325;0.000259)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00057)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		GAGAGGGGCCGAGCAGCACCA	0.687		NaN											0	0	0	0.217242	0	6	12									
ZC3H12A	80149	broad.mit.edu	37	1	37945897	37945897	+	Silent	SNP	G	G	T			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr1:37945897G>T	uc001cbb.3	+	3	600	c.450G>T	c.(448-450)GGG>GGT	p.G150G	ZC3H12A_uc001cbc.1_5'UTR	NM_025079	NP_079355	Q5D1E8	ZC12A_HUMAN	zinc finger CCCH-type containing 12A	150					angiogenesis|apoptosis|cell differentiation	cytoplasm|nucleus|plasma membrane	endonuclease activity|metal ion binding			ovary(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CCAGCCATGGGAACAAGGAGG	0.632		NaN											1	0	2.7689e-08	0.248553	3.11215e-08	6	41									
ZC3H12A	80149	broad.mit.edu	37	1	37945923	37945923	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr1:37945923G>A	uc001cbb.3	+	3	626	c.476G>A	c.(475-477)GGC>GAC	p.G159D	ZC3H12A_uc001cbc.1_5'UTR	NM_025079	NP_079355	Q5D1E8	ZC12A_HUMAN	zinc finger CCCH-type containing 12A	159					angiogenesis|apoptosis|cell differentiation	cytoplasm|nucleus|plasma membrane	endonuclease activity|metal ion binding			ovary(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TCCTGCCGGGGCATCCTGCTG	0.637		NaN											0	0	0	0.047766	0	8	43									
ZC3H12A	80149	broad.mit.edu	37	1	37946006	37946006	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr1:37946006C>T	uc001cbb.3	+	3	709	c.559C>T	c.(559-561)CCT>TCT	p.P187S	ZC3H12A_uc001cbc.1_5'UTR	NM_025079	NP_079355	Q5D1E8	ZC12A_HUMAN	zinc finger CCCH-type containing 12A	187					angiogenesis|apoptosis|cell differentiation	cytoplasm|nucleus|plasma membrane	endonuclease activity|metal ion binding			ovary(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GAAGGAGCAGCCTCGGCCCGA	0.627		NaN											0	0	0	0.115264	0	3	29									
KDM4A	9682	broad.mit.edu	37	1	44137208	44137208	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr1:44137208G>C	uc001cjx.2	+	11	1562	c.1396G>C	c.(1396-1398)GAG>CAG	p.E466Q	KDM4A_uc010oki.1_Intron	NM_014663	NP_055478	O75164	KDM4A_HUMAN	jumonji domain containing 2A	466					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleolus	histone demethylase activity (H3-K36 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			skin(1)	1						CAAATTTGAAGAGCTTAAAAA	0.428		NaN											0	0	0	0.038147	0	5	76									
KDM4A	9682	broad.mit.edu	37	1	44137256	44137256	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr1:44137256G>C	uc001cjx.2	+	11	1610	c.1444G>C	c.(1444-1446)GCA>CCA	p.A482P	KDM4A_uc010oki.1_Intron	NM_014663	NP_055478	O75164	KDM4A_HUMAN	jumonji domain containing 2A	482					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleolus	histone demethylase activity (H3-K36 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			skin(1)	1						GGAAGAACAAGCAGCAGCTGC	0.448		NaN											0	0	0	0.058154	0	7	95									
KDM4A	9682	broad.mit.edu	37	1	44137463	44137463	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr1:44137463G>C	uc001cjx.2	+	11	1817	c.1651G>C	c.(1651-1653)GAT>CAT	p.D551H	KDM4A_uc010oki.1_Intron	NM_014663	NP_055478	O75164	KDM4A_HUMAN	jumonji domain containing 2A	551					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleolus	histone demethylase activity (H3-K36 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			skin(1)	1						TGCCAAAGGGGATGGCAGGGT	0.562		NaN											0	0	0	0.160694	0	15	114									
RPS8	6202	broad.mit.edu	37	1	45242394	45242394	+	Silent	SNP	G	G	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr1:45242394G>A	uc001cmi.2	+	3	182	c.159G>A	c.(157-159)AAG>AAA	p.K53K	SNORD38A_uc009vxi.2_5'Flank|SNORD38B_uc001cml.2_5'Flank	NM_001012	NP_001003	P62241	RS8_HUMAN	ribosomal protein S8	53					endocrine pancreas development|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	protein binding|structural constituent of ribosome			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					GAGGTAACAAGAAATACCGTG	0.562		NaN											0	0	0	0.058154	0	10	39									
STIL	6491	broad.mit.edu	37	1	47725990	47725990	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr1:47725990C>G	uc001crc.1	-	16	3203	c.3048G>C	c.(3046-3048)AAG>AAC	p.K1016N	TAL1_uc001crb.1_Intron|STIL_uc010omn.1_Missense_Mutation_p.K970N|STIL_uc010omo.1_Missense_Mutation_p.K999N|STIL_uc001crd.1_Missense_Mutation_p.K1017N|STIL_uc001cre.1_Missense_Mutation_p.K1016N|STIL_uc001crf.1_Missense_Mutation_p.K629N|STIL_uc001crg.1_Missense_Mutation_p.K952N	NM_003035	NP_003026	Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus isoform 2	1016					cell proliferation|multicellular organismal development	centrosome|cytosol				lung(2)|skin(1)	3		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				GTGCATTTTTCTTCACTTTAG	0.308		NaN											0	0	0	0.246493	0	41	10									
PPFIA4	8497	broad.mit.edu	37	1	203024673	203024673	+	Missense_Mutation	SNP	C	C	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr1:203024673C>A	uc001gyz.2	+	3	1018	c.425C>A	c.(424-426)TCC>TAC	p.S142Y	PPFIA4_uc009xaj.2_Missense_Mutation_p.S773Y|PPFIA4_uc010pqf.1_Missense_Mutation_p.S355Y|PPFIA4_uc001gza.2_Missense_Mutation_p.S142Y|PPFIA4_uc001gzb.1_5'Flank	NM_015053	NP_055868	O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f	142					cell communication	cell surface|cytoplasm	protein binding			ovary(4)|skin(1)	5						AAGCGTGGTTCCATCCCCACC	0.652		NaN											1	0	0.000673444	0.069234	0.000704526	11	33									
THNSL1	79896	broad.mit.edu	37	10	25314303	25314303	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr10:25314303G>C	uc001isi.3	+	3	2480	c.2151G>C	c.(2149-2151)AAG>AAC	p.K717N	ENKUR_uc001ish.1_Intron	NM_024838	NP_079114	Q8IYQ7	THNS1_HUMAN	threonine synthase-like 1	717					threonine biosynthetic process		ATP binding|pyridoxal phosphate binding|shikimate kinase activity|threonine synthase activity			pancreas(1)	1					L-Threonine(DB00156)|Pyridoxal Phosphate(DB00114)	AGCAAGAGAAGATGGAGTACC	0.388		NaN											0	0	0	0.058154	0	9	40									
ZNF365	22891	broad.mit.edu	37	10	64415128	64415128	+	Missense_Mutation	SNP	C	C	T	rs79964532		TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr10:64415128C>T	uc001jmd.1	+	4	462	c.128C>T	c.(127-129)TCA>TTA	p.S43L	ZNF365_uc001jmc.2_Intron|ZNF365_uc001jme.1_Intron|ZNF365_uc001jmf.1_Intron|ZNF365_uc009xpg.1_Intron	NM_199452	NP_955524	Q70YC4	TALAN_HUMAN	zinc finger protein 365 isoform D	43										ovary(1)|skin(1)	2	Prostate(12;0.0297)|all_hematologic(501;0.228)					TCCACAAAGTCAACACATCTA	0.408		NaN											0	0	0	0.038147	0	7	16									
PSAP	5660	broad.mit.edu	37	10	73587834	73587834	+	Silent	SNP	G	G	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr10:73587834G>A	uc001jsm.2	-	6	761	c.657C>T	c.(655-657)GTC>GTT	p.V219V		NM_002778	NP_002769	P07602	SAP_HUMAN	prosaposin isoform a preproprotein	219	Saposin B-type 2.				glycosphingolipid metabolic process|lipid transport|platelet activation|platelet degranulation	extracellular space|Golgi apparatus|integral to membrane|lysosomal lumen	enzyme activator activity|lipid binding			ovary(1)	1						CCAAGGCCTGGACAAAGGTGG	0.552		NaN											0	0	0	0.184627	0	5	50									
TLL2	7093	broad.mit.edu	37	10	98136543	98136543	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr10:98136543C>T	uc001kml.1	-	18	2580	c.2354G>A	c.(2353-2355)GGG>GAG	p.G785E		NM_012465	NP_036597	Q9Y6L7	TLL2_HUMAN	tolloid-like 2 precursor	785	CUB 4.				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		CGCCAGGGTCCCCTCCACACT	0.572		NaN											0	0	0	0.203993	0	35	15									
OR51S1	119692	broad.mit.edu	37	11	4869946	4869946	+	Silent	SNP	G	G	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr11:4869946G>A	uc010qyo.1	-	1	493	c.493C>T	c.(493-495)CTG>TTG	p.L165L		NM_001004758	NP_001004758	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S,	165	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		GGCAGGGGCAGATGGAGACCC	0.557		NaN											0	0	0	0.09319	0	12	44									
MMP26	56547	broad.mit.edu	37	11	5009489	5009489	+	Silent	SNP	C	C	T			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr11:5009489C>T	uc001lzv.2	+	1	66	c.48C>T	c.(46-48)TTC>TTT	p.F16F		NM_021801	NP_068573	Q9NRE1	MMP26_HUMAN	matrix metalloproteinase 26 preproprotein	16					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Medulloblastoma(188;0.0025)|Breast(177;0.0204)|all_neural(188;0.0227)		Epithelial(150;1.33e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0287)|LUSC - Lung squamous cell carcinoma(625;0.191)		CCTGGTGTTTCGCCGTTCCAG	0.502		NaN									OREG0003716	type=REGULATORY REGION|Gene=MMP26|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	0	0	0	0.26419	0	21	31									
ABCC8	6833	broad.mit.edu	37	11	17436131	17436131	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr11:17436131G>A	uc001mnc.2	-	19	2444	c.2318C>T	c.(2317-2319)TCG>TTG	p.S773L		NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	773	ABC transporter 1.|Cytoplasmic (By similarity).				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	TGGTTTCTGCGAAGCATAGGC	0.547		NaN											0	0	0	0.099896	0	26	37									
DTX4	23220	broad.mit.edu	37	11	58962721	58962721	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr11:58962721G>C	uc001nns.2	+	7	1672	c.1415G>C	c.(1414-1416)GGG>GCG	p.G472A	DTX4_uc001nnr.2_Missense_Mutation_p.G366A	NM_015177	NP_055992	Q9Y2E6	DTX4_HUMAN	deltex 4 homolog	472					Notch signaling pathway	cytoplasm	zinc ion binding			lung(2)|central_nervous_system(1)	3		all_epithelial(135;0.125)				ACCATTTATGGGGTGAAGACA	0.532		NaN											0	0	0	0.105934	0	13	35									
ANKRD13D	338692	broad.mit.edu	37	11	67068497	67068497	+	Silent	SNP	G	G	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr11:67068497G>A	uc001okc.1	+	12	1360	c.849G>A	c.(847-849)CCG>CCA	p.P283P	ANKRD13D_uc001okd.1_Silent_p.P370P|ANKRD13D_uc001oke.1_Silent_p.P283P|ANKRD13D_uc001okg.1_Silent_p.P66P|ANKRD13D_uc001okh.1_Silent_p.P66P|ANKRD13D_uc001oki.1_Silent_p.P20P|SSH3_uc001okj.2_5'Flank|SSH3_uc001okk.2_5'Flank|SSH3_uc001okl.2_5'Flank	NM_207354	NP_997237	Q6ZTN6	AN13D_HUMAN	ankyrin repeat domain 13 family, member D	283										ovary(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			AAGAGCACCCGCTCTCCCTGG	0.612		NaN											0	0	0	0.11911	0	15	46									
FAT3	120114	broad.mit.edu	37	11	92088561	92088561	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr11:92088561G>A	uc001pdj.3	+	1	3300	c.3283G>A	c.(3283-3285)GAC>AAC	p.D1095N		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1095	Cadherin 10.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CAGTATAGACGACGAGAGTGG	0.453		NaN								TCGA Ovarian(4;0.039)			0	0	0	0.184627	0	5	24									
FOLR4	390243	broad.mit.edu	37	11	94039818	94039818	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr11:94039818C>T	uc010rud.1	+	2	278	c.278C>T	c.(277-279)GCT>GTT	p.A93V		NM_001080486	NP_001073955	A6ND01	FOLR4_HUMAN	folate receptor 4 (delta) homolog	93						extracellular region	folic acid binding|receptor activity			ovary(1)	1						TTCATCCAGGCTATCTGCTTC	0.567		NaN											0	0	0	0.160694	0	18	43									
GRIA4	2893	broad.mit.edu	37	11	105795422	105795422	+	Nonsense_Mutation	SNP	G	G	T			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr11:105795422G>T	uc001pix.2	+	12	2220	c.1774G>T	c.(1774-1776)GAG>TAG	p.E592*	GRIA4_uc001piw.2_Nonsense_Mutation_p.E592*	NM_000829	NP_000820	P48058	GRIA4_HUMAN	glutamate receptor, ionotrophic, AMPA 4 isoform	592	Cytoplasmic (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	GCCTCCCAATGAGTTTGGCAT	0.468		NaN											1	0	1.12685e-05	0.047766	1.19728e-05	9	15									
ZC3H12C	85463	broad.mit.edu	37	11	110035202	110035202	+	Silent	SNP	G	G	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr11:110035202G>A	uc009yxw.2	+	6	1443	c.1392G>A	c.(1390-1392)CTG>CTA	p.L464L	ZC3H12C_uc010rwc.1_Silent_p.L465L|ZC3H12C_uc010rwd.1_Silent_p.L465L|ZC3H12C_uc001pkr.3_Silent_p.L433L	NM_033390	NP_203748	Q9C0D7	ZC12C_HUMAN	zinc finger CCCH-type containing 12C	464							endonuclease activity|nucleic acid binding|zinc ion binding				0		all_cancers(61;3.24e-13)|all_epithelial(67;1.27e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.72e-06)|BRCA - Breast invasive adenocarcinoma(274;1.17e-05)|all cancers(92;9e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0279)		AAGGAGGACTGGTGAAAAGCA	0.512		NaN											0	0	0	0.115264	0	3	23									
KCNA6	3742	broad.mit.edu	37	12	4920041	4920041	+	Silent	SNP	C	C	T			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr12:4920041C>T	uc001qng.2	+	1	1700	c.834C>T	c.(832-834)CTC>CTT	p.L278L		NM_002235	NP_002226	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related	278	Helical; Name=Segment S2; (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(2)|ovary(1)	3						CTTTTGAGCTCCTGGTGCGCT	0.557		NaN								HNSCC(72;0.22)			0	0	0	0.0918	0	25	71									
MLL2	8085	broad.mit.edu	37	12	49434618	49434618	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr12:49434618G>A	uc001rta.3	-	31	6935	c.6935C>T	c.(6934-6936)TCA>TTA	p.S2312L		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2312	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GTGGGTGCCTGAGGAGGGTGA	0.617		NaN	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.038147	0	8	22									
CPSF6	11052	broad.mit.edu	37	12	69652453	69652453	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr12:69652453C>T	uc001sut.3	+	6	888	c.778C>T	c.(778-780)CCT>TCT	p.P260S	CPSF6_uc001suu.3_Missense_Mutation_p.P297S|CPSF6_uc010stk.1_5'UTR	NM_007007	NP_008938	Q16630	CPSF6_HUMAN	cleavage and polyadenylation specific factor 6,	260	Pro-rich.				mRNA polyadenylation|protein tetramerization	mRNA cleavage factor complex|paraspeckles|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding				0	all_epithelial(5;2.47e-36)|Lung NSC(4;1.1e-32)|all_lung(4;6.26e-31)|Breast(13;1.59e-06)|Esophageal squamous(21;0.187)		Epithelial(6;4.89e-17)|BRCA - Breast invasive adenocarcinoma(5;8.5e-10)|Lung(24;6.04e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|LUSC - Lung squamous cell carcinoma(43;0.171)|Kidney(9;0.241)			TCAGGTTCTGCCTCCTCCTCT	0.577		NaN											0	0	0	0.099896	0	27	842									
UBE2N	7334	broad.mit.edu	37	12	93803827	93803827	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr12:93803827C>T	uc001tcp.2	-	4	813	c.447G>A	c.(445-447)ATG>ATA	p.M149I		NM_003348	NP_003339	P61088	UBE2N_HUMAN	ubiquitin-conjugating enzyme E2N	149					DNA double-strand break processing|double-strand break repair via homologous recombination|histone ubiquitination|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of DNA repair|positive regulation of histone modification|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity|postreplication repair|protein K63-linked ubiquitination|proteolysis|regulation of histone ubiquitination|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleus|UBC13-MMS2 complex|UBC13-UEV1A complex|ubiquitin ligase complex	ATP binding|ubiquitin binding|ubiquitin-protein ligase activity				0						AAATATTATTCATGGCATATA	0.348		NaN						Direct_reversal_of_damage|Rad6_pathway					0	0	0	0.038147	0	8	14									
FBXO21	23014	broad.mit.edu	37	12	117628253	117628253	+	Silent	SNP	C	C	T			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr12:117628253C>T	uc001twk.2	-	1	48	c.9G>A	c.(7-9)GCG>GCA	p.A3A	FBXO21_uc001twj.2_Silent_p.A3A|FBXO21_uc009zwq.2_Silent_p.A3A	NM_033624	NP_296373	O94952	FBX21_HUMAN	F-box only protein 21 isoform 1	3					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			kidney(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0291)		cgactgctgccgccgccATCT	0.478		NaN											0	0	0	0.115264	0	2	2									
CLIP1	6249	broad.mit.edu	37	12	122812709	122812709	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr12:122812709C>T	uc001ucg.1	-	16	3140	c.3034G>A	c.(3034-3036)GAA>AAA	p.E1012K	CLIP1_uc001uch.1_Missense_Mutation_p.E1001K|CLIP1_uc001uci.1_Missense_Mutation_p.E966K|CLIP1_uc001ucj.1_Missense_Mutation_p.E587K	NM_002956	NP_002947	P30622	CLIP1_HUMAN	restin isoform a	1012	Potential.				mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			ovary(2)|breast(1)	3	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		ATTTTCTTTTCCTGCAGAGAC	0.493		NaN											0	0	0	0.249174	0	10	68									
SPATA13	221178	broad.mit.edu	37	13	24868942	24868942	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr13:24868942G>A	uc001upg.1	+	9	1678	c.1271G>A	c.(1270-1272)CGC>CAC	p.R424H	SPATA13_uc001upd.1_Missense_Mutation_p.R1049H|C1QTNF9_uc001upe.2_RNA|SPATA13_uc010tcy.1_Missense_Mutation_p.R370H|SPATA13_uc010tcz.1_Missense_Mutation_p.R308H|SPATA13_uc010tda.1_Missense_Mutation_p.R368H|SPATA13_uc001uph.2_Missense_Mutation_p.R346H|SPATA13_uc010tdb.1_Missense_Mutation_p.R284H|SPATA13_uc009zzz.1_Intron|SPATA13_uc001upi.1_5'Flank	NM_153023	NP_694568	Q96N96	SPT13_HUMAN	spermatogenesis associated 13	424	DH.				cell migration|filopodium assembly|lamellipodium assembly|regulation of cell migration|regulation of Rho protein signal transduction	cytoplasm|filopodium|lamellipodium|ruffle membrane	protein binding|Rac guanyl-nucleotide exchange factor activity			skin(2)|ovary(1)	3		all_cancers(29;4.05e-15)|all_lung(29;2.77e-14)|all_epithelial(30;7.77e-13)|Lung SC(185;0.0279)		all cancers(112;0.00616)|Epithelial(112;0.0195)|OV - Ovarian serous cystadenocarcinoma(117;0.0705)|Lung(94;0.231)		ATCAACGAGCGCAAGCGCAAG	0.498		NaN											0	0	0	0.150653	0	4	35									
RBM26	64062	broad.mit.edu	37	13	79928636	79928636	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr13:79928636G>C	uc001vkz.2	-	13	1944	c.1930C>G	c.(1930-1932)CCA>GCA	p.P644A	RBM26_uc001vky.2_Missense_Mutation_p.P639A|RBM26_uc001vla.2_Missense_Mutation_p.P642A|RBM26_uc010tia.1_Missense_Mutation_p.P23A|RBM26_uc001vkx.2_Missense_Mutation_p.P354A	NM_022118	NP_071401	Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	642					mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		GAAGGTACTGGACCCAGCCGC	0.463		NaN											0	0	0	0.173368	0	36	9									
DCUN1D2	55208	broad.mit.edu	37	13	114138370	114138370	+	Missense_Mutation	SNP	T	T	C			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr13:114138370T>C	uc001vtr.1	-	2	44	c.5A>G	c.(4-6)CAT>CGT	p.H2R	DCUN1D2_uc001vts.1_RNA|DCUN1D2_uc010agw.1_Intron	NM_001014283	NP_001014305	Q6PH85	DCNL2_HUMAN	DCN1, defective in cullin neddylation 1, domain	2											0	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0395)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.029)|GBM - Glioblastoma multiforme(44;0.234)			TTTAAGCTTATGCTTTGGGAT	0.493		NaN											0	0	0	0.139131	0	57	13									
FBN1	2200	broad.mit.edu	37	15	48905226	48905226	+	Silent	SNP	G	G	T	rs141651917	byFrequency	TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr15:48905226G>T	uc001zwx.1	-	3	556	c.228C>A	c.(226-228)GGC>GGA	p.G76G		NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	76					heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		ACTGATTTCCGCCAGGTAAGG	0.393		NaN											1	0	0.00316338	0.132662	0.00321059	14	54									
ATP8B4	79895	broad.mit.edu	37	15	50158634	50158634	+	Silent	SNP	G	G	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr15:50158634G>A	uc001zxu.2	-	26	3217	c.3075C>T	c.(3073-3075)ATC>ATT	p.I1025I	ATP8B4_uc010ber.2_Silent_p.I898I|ATP8B4_uc010ufd.1_Silent_p.I835I|ATP8B4_uc010ufe.1_RNA|ATP8B4_uc001zxt.2_Silent_p.I28I	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	1025	Helical; (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		TGCTCCCCCAGATGAAGACGT	0.388		NaN											0	0	0	0.204396	0	19	44									
ATP8B4	79895	broad.mit.edu	37	15	50189507	50189507	+	Silent	SNP	G	G	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr15:50189507G>A	uc001zxu.2	-	23	2821	c.2679C>T	c.(2677-2679)TTC>TTT	p.F893F	ATP8B4_uc010ber.2_Silent_p.F766F|ATP8B4_uc010ufd.1_Silent_p.F703F|ATP8B4_uc010ufe.1_RNA|ATP8B4_uc001zxv.1_Silent_p.F191F	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	893	Extracellular (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		AGAAACCACAGAAGAAACCAA	0.299		NaN											0	0	0	0.083992	0	26	81									
KIAA1370	56204	broad.mit.edu	37	15	52903959	52903959	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr15:52903959G>A	uc002acg.3	-	4	370	c.217C>T	c.(217-219)CGA>TGA	p.R73*	KIAA1370_uc002ach.3_RNA|KIAA1370_uc010bfg.1_Translation_Start_Site|KIAA1370_uc010ugf.1_Nonsense_Mutation_p.R80*	NM_019600	NP_062546	Q32MH5	K1370_HUMAN	hypothetical protein LOC56204	73											0				all cancers(107;0.0803)		GACCTAGTTCGTCTGGCTTGG	0.398		NaN											0	0	0	0.11911	0	13	43									
ZNF280D	54816	broad.mit.edu	37	15	56961028	56961028	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr15:56961028C>G	uc002adu.2	-	14	1755	c.1538G>C	c.(1537-1539)GGA>GCA	p.G513A	ZNF280D_uc002adv.2_Missense_Mutation_p.G500A|ZNF280D_uc010bfq.2_Missense_Mutation_p.G513A|ZNF280D_uc002adw.1_Missense_Mutation_p.G541A|ZNF280D_uc010bfr.1_RNA|ZNF280D_uc010bfp.2_RNA	NM_017661	NP_060131	Q6N043	Z280D_HUMAN	suppressor of hairy wing homolog 4 isoform 1	513					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.0399)|GBM - Glioblastoma multiforme(80;0.0787)		CACTTTTGTTCCAGGAGGCAA	0.318		NaN											0	0	0	0.038147	0	7	26									
SCAPER	49855	broad.mit.edu	37	15	76994184	76994184	+	Missense_Mutation	SNP	A	A	T			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr15:76994184A>T	uc002bby.2	-	19	2482	c.2423T>A	c.(2422-2424)TTT>TAT	p.F808Y	SCAPER_uc010bkr.2_Missense_Mutation_p.F116Y|SCAPER_uc002bbx.2_Missense_Mutation_p.F562Y|SCAPER_uc002bbz.1_Missense_Mutation_p.F679Y|SCAPER_uc002bca.1_Missense_Mutation_p.F673Y	NM_020843	NP_065894	Q9BY12	SCAPE_HUMAN	S-phase cyclin A-associated protein in the ER	807	C2H2-type.					endoplasmic reticulum|nucleus	zinc ion binding			large_intestine(1)|lung(1)|ovary(1)	3						AACATGGCTAAAAAGATATAC	0.358		NaN											0	0	0	0.11911	0	13	19									
HOMER2	9455	broad.mit.edu	37	15	83532988	83532988	+	Silent	SNP	C	C	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr15:83532988C>A	uc002bjg.2	-	4	504	c.318G>T	c.(316-318)GTG>GTT	p.V106V	HOMER2_uc002bjh.2_Silent_p.V106V|HOMER2_uc002bjj.2_Silent_p.V106V|HOMER2_uc002bji.2_Silent_p.V106V	NM_199330	NP_955362	Q9NSB8	HOME2_HUMAN	homer 2 isoform 2	106	Potential.|WH1.				metabotropic glutamate receptor signaling pathway	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane					0						CAGCTTCTTTCACCTCCTGGA	0.388		NaN											1	0	2.0095e-06	0.248553	2.20397e-06	6	23									
BNC1	646	broad.mit.edu	37	15	83933066	83933066	+	Missense_Mutation	SNP	T	T	C			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr15:83933066T>C	uc002bjt.1	-	4	1025	c.937A>G	c.(937-939)AAA>GAA	p.K313E	BNC1_uc010uos.1_Missense_Mutation_p.K301E	NM_001717	NP_001708	Q01954	BNC1_HUMAN	basonuclin 1	313					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						TCTTCTTTTTTAGTAATAGCA	0.438		NaN											0	0	0	0.09319	0	12	47									
POLR3E	55718	broad.mit.edu	37	16	22320249	22320249	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr16:22320249G>A	uc002dkk.2	+	5	325	c.169G>A	c.(169-171)GAG>AAG	p.E57K	POLR3E_uc002dkj.1_Missense_Mutation_p.E57K|POLR3E_uc002dkm.2_Missense_Mutation_p.E21K|POLR3E_uc010vbr.1_Missense_Mutation_p.E57K|POLR3E_uc002dkl.2_Missense_Mutation_p.E57K|POLR3E_uc010vbs.1_Missense_Mutation_p.E21K|POLR3E_uc010vbt.1_Intron	NM_018119	NP_060589	Q9NVU0	RPC5_HUMAN	RNA polymerase III polypeptide E	57					innate immune response|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA-directed RNA polymerase activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(48;0.012)		CCTCCAGGTAGAGCTTGAGAT	0.627		NaN											0	0	0	0.09319	0	13	33									
IRX5	10265	broad.mit.edu	37	16	54966775	54966775	+	Silent	SNP	G	G	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr16:54966775G>A	uc002ehv.2	+	2	615	c.615G>A	c.(613-615)CAG>CAA	p.Q205Q	IRX5_uc010cca.1_Silent_p.Q257Q|IRX5_uc002ehw.2_Silent_p.Q139Q	NM_005853	NP_005844	P78411	IRX5_HUMAN	iroquois homeobox protein 5	205					response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|vitamin D binding				0						ACGAGCCCCAGAAGCCCGAGG	0.592		NaN											0	0	0	0.11911	0	14	41									
ZZEF1	23140	broad.mit.edu	37	17	3974013	3974013	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr17:3974013C>T	uc002fxe.2	-	26	4104	c.4040G>A	c.(4039-4041)CGC>CAC	p.R1347H	ZZEF1_uc002fxj.1_5'UTR	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	1347							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						ATCTGGAGTGCGATACACCAG	0.393		NaN											0	0	0	0.160694	0	18	42									
CNTROB	116840	broad.mit.edu	37	17	7838454	7838454	+	Silent	SNP	C	C	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr17:7838454C>A	uc002gjq.2	+	5	1504	c.585C>A	c.(583-585)ACC>ACA	p.T195T	CNTROB_uc002gjp.2_Silent_p.T195T|CNTROB_uc002gjr.2_Silent_p.T97T|CNTROB_uc010vum.1_5'Flank	NM_053051	NP_444279	Q8N137	CNTRB_HUMAN	centrobin, centrosomal BRCA2 interacting protein	195					centriole replication|centrosome separation|cytokinesis	centriole	protein domain specific binding			breast(1)|central_nervous_system(1)	2		Prostate(122;0.173)				CAGAGCATACCCGCCGCAAGG	0.502		NaN											1	0	0.004672	0.115264	0.00470661	3	19									
ITGA3	3675	broad.mit.edu	37	17	48149456	48149456	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr17:48149456C>T	uc010dbl.2	+	7	1530	c.1066C>T	c.(1066-1068)CAC>TAC	p.H356Y	ITGA3_uc010dbm.2_Missense_Mutation_p.H356Y	NM_002204	NP_002195	P26006	ITA3_HUMAN	integrin alpha 3 isoform a precursor	356	FG-GAP 6.|Extracellular (Potential).				blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|leukocyte migration	cell surface|integrin complex	protein binding|receptor activity			ovary(2)|pancreas(1)	3						CTTCCCTGCTCACCCCTCACT	0.562		NaN											0	0	0	0.189662	0	19	43									
WFIKKN2	124857	broad.mit.edu	37	17	48917902	48917902	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr17:48917902G>A	uc002isv.3	+	2	1947	c.1253G>A	c.(1252-1254)GGC>GAC	p.G418D	WFIKKN2_uc010dbu.2_Missense_Mutation_p.G325D	NM_175575	NP_783165	Q8TEU8	WFKN2_HUMAN	WFIKKN2 protein	418	BPTI/Kunitz inhibitor 2.					extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			GTCTATGGTGGCTGCGAGGGC	0.667		NaN											0	0	0	0.175082	0	18	35									
CA10	56934	broad.mit.edu	37	17	49710985	49710985	+	Missense_Mutation	SNP	C	C	A	rs149523462		TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr17:49710985C>A	uc002itw.3	-	8	1802	c.816G>T	c.(814-816)CAG>CAT	p.Q272H	CA10_uc002itu.3_Missense_Mutation_p.Q201H|CA10_uc002itv.3_Missense_Mutation_p.Q278H|CA10_uc002itx.3_Missense_Mutation_p.Q272H|CA10_uc002ity.3_Missense_Mutation_p.Q272H|CA10_uc002itz.2_Missense_Mutation_p.Q272H	NM_020178	NP_064563	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	272					brain development					ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			ATGGCTGGTTCTGGCTGAGCA	0.498		NaN											1	0	2.23348e-06	0.146539	2.43003e-06	15	46									
TRIP10	9322	broad.mit.edu	37	19	6750343	6750343	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr19:6750343G>T	uc002mfs.2	+	13	1502	c.1436G>T	c.(1435-1437)CGG>CTG	p.R479L	TRIP10_uc010dux.1_Missense_Mutation_p.R423L|TRIP10_uc002mfr.2_Missense_Mutation_p.R423L|TRIP10_uc010duy.2_RNA|TRIP10_uc010duz.2_Missense_Mutation_p.R242L	NM_004240	NP_004231	Q15642	CIP4_HUMAN	thyroid hormone receptor interactor 10	479	Interaction with CDC42.|Interaction with PDE6G (By similarity).|REM.|Required for interaction with FASLG and localization to lysosomes.				actin cytoskeleton organization|cell communication|endocytosis|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell projection|cytoskeleton|cytosol|Golgi apparatus|lysosome|perinuclear region of cytoplasm|phagocytic cup	GTPase activator activity|identical protein binding|lipid binding			ovary(1)	1						CTTAGCAACCGGGGAGACAGC	0.667		NaN											1	0	0.00185496	0.105934	0.00192576	13	47									
APLP1	333	broad.mit.edu	37	19	36369487	36369487	+	Silent	SNP	G	G	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr19:36369487G>A	uc002oce.2	+	14	1716	c.1578G>A	c.(1576-1578)GGG>GGA	p.G526G	APLP1_uc010xsz.1_Silent_p.G487G|APLP1_uc002ocf.2_Silent_p.G527G|APLP1_uc002ocg.2_Silent_p.G430G|APLP1_uc010xta.1_Silent_p.G520G	NM_005166	NP_005157	P51693	APLP1_HUMAN	amyloid precursor-like protein 1 isoform 2	526	Extracellular (Potential).				apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			ovary(2)	2	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TGGGGGTAGGGTCCACAGAAC	0.308		NaN											0	0	0	0.047766	0	8	28									
ACTN4	81	broad.mit.edu	37	19	39191751	39191751	+	Silent	SNP	C	C	T			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr19:39191751C>T	uc002oja.1	+	3	446	c.387C>T	c.(385-387)ATC>ATT	p.I129I	ACTN4_uc010egc.1_Silent_p.I129I	NM_004924	NP_004915	O43707	ACTN4_HUMAN	actinin, alpha 4	129	Actin-binding.|CH 1.				platelet activation|platelet degranulation|positive regulation of cellular component movement|positive regulation of sodium:hydrogen antiporter activity|protein transport|regulation of apoptosis	extracellular region|nucleolus|perinuclear region of cytoplasm|platelet alpha granule lumen|protein complex|pseudopodium|ribonucleoprotein complex	actin filament binding|calcium ion binding|integrin binding|nucleoside binding|protein homodimerization activity				0	all_cancers(60;1.57e-05)|Ovarian(47;0.103)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			TGGTCTCCATCGGGGCAGAAG	0.532		NaN											0	0	0	0.160694	0	16	30									
FCGBP	8857	broad.mit.edu	37	19	40367841	40367841	+	Silent	SNP	T	T	G			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr19:40367841T>G	uc002omp.3	-	29	13127	c.13119A>C	c.(13117-13119)GCA>GCC	p.A4373A		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4373	TIL 10.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TCGTAAGGGGTGCAGGGGACG	0.627		NaN											0	0	0	0.146539	0	7	29									
NKPD1	284353	broad.mit.edu	37	19	45656276	45656276	+	Silent	SNP	G	G	C			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr19:45656276G>C	uc010xxi.1	-	4	1419	c.1419C>G	c.(1417-1419)CTC>CTG	p.L473L		NM_198478	NP_940880			NTPase, KAP family P-loop domain containing 1												0		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00863)|GBM - Glioblastoma multiforme(486;0.231)		TGATGGCGTTGAGCACGCCCA	0.672		NaN											0	0	0	0.115264	0	3	7									
NKPD1	284353	broad.mit.edu	37	19	45656867	45656867	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr19:45656867G>T	uc010xxi.1	-	4	828	c.828C>A	c.(826-828)TTC>TTA	p.F276L		NM_198478	NP_940880			NTPase, KAP family P-loop domain containing 1												0		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00863)|GBM - Glioblastoma multiforme(486;0.231)		GGATGAAAAGGAACTGCACGT	0.662		NaN											1	0	0.00024832	0.150653	0.000261795	3	7									
SAE1	10055	broad.mit.edu	37	19	47646815	47646815	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr19:47646815C>T	uc002pgc.2	+	2	219	c.163C>T	c.(163-165)CTC>TTC	p.L55F	SAE1_uc002pgd.2_Missense_Mutation_p.L55F|SAE1_uc010ekx.2_Missense_Mutation_p.L55F|SAE1_uc010ekw.2_RNA|SAE1_uc010xyk.1_5'UTR|SAE1_uc002pge.2_5'UTR	NM_016402	NP_057486	Q9UBE0	SAE1_HUMAN	SubName: Full=SUMO-1 activating enzyme subunit 1, isoform CRA_b; SubName: Full=cDNA, FLJ96708, Homo sapiens SUMO-1 activating enzyme subunit 1 (SAE1), mRNA;	55					protein sumoylation|protein ubiquitination	nucleus	ATP-dependent protein binding|enzyme activator activity|ligase activity|protein C-terminus binding|protein heterodimerization activity|ubiquitin activating enzyme activity			ovary(1)	1		all_cancers(25;1.13e-05)|all_lung(116;0.000192)|all_epithelial(76;0.000274)|Lung NSC(112;0.000446)|all_neural(266;0.0652)|Ovarian(192;0.15)		all cancers(93;0.00013)|OV - Ovarian serous cystadenocarcinoma(262;0.000146)|Epithelial(262;0.00697)|GBM - Glioblastoma multiforme(486;0.0278)		TGCCAAGAATCTCATCTTGGC	0.522		NaN											0	0	0	0.189662	0	17	80									
CLEC11A	6320	broad.mit.edu	37	19	51228559	51228559	+	Silent	SNP	C	C	T			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr19:51228559C>T	uc002psy.2	+	4	985	c.807C>T	c.(805-807)CGC>CGT	p.R269R		NM_002975	NP_002966	Q9Y240	CLC11_HUMAN	stem cell growth factor precursor	269	C-type lectin.				positive regulation of cell proliferation	cytoplasm|extracellular region	growth factor activity|sugar binding			ovary(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		GCTCACCCCGCCCCGAGCTCG	0.726		NaN											0	0	0	0.069234	0	9	7									
ZNF615	284370	broad.mit.edu	37	19	52498046	52498046	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr19:52498046G>A	uc002pye.1	-	6	575	c.283C>T	c.(283-285)CAA>TAA	p.Q95*	ZNF615_uc002pyf.1_Nonsense_Mutation_p.Q106*|ZNF615_uc002pyg.1_5'UTR|ZNF615_uc002pyh.1_Nonsense_Mutation_p.Q106*|ZNF615_uc010epi.1_Nonsense_Mutation_p.Q102*|ZNF615_uc010ydg.1_Nonsense_Mutation_p.Q100*	NM_198480	NP_940882	Q8N8J6	ZN615_HUMAN	zinc finger protein 615	95					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		TGAATACTTTGATTTTGCAAG	0.348		NaN											0	0	0	0.249174	0	20	20									
VSTM1	284415	broad.mit.edu	37	19	54544246	54544246	+	Missense_Mutation	SNP	C	C	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr19:54544246C>A	uc002qcw.3	-	9	856	c.680G>T	c.(679-681)GGA>GTA	p.G227V	VSTM1_uc010erb.2_RNA|VSTM1_uc002qcx.3_Missense_Mutation_p.G196V	NM_198481	NP_940883	Q6UX27	VSTM1_HUMAN	V-set and transmembrane domain containing 1	227						integral to membrane					0	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.165)		TTCATGAGATCCTGGGGGCTC	0.557		NaN											1	0	1.5739e-10	0.146539	1.79874e-10	15	14									
FIZ1	84922	broad.mit.edu	37	19	56104596	56104596	+	Silent	SNP	G	G	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr19:56104596G>A	uc002qli.3	-	3	801	c.711C>T	c.(709-711)TTC>TTT	p.F237F	FIZ1_uc002qlj.3_Silent_p.F237F	NM_032836	NP_116225	Q96SL8	FIZ1_HUMAN	FLT3-interacting zinc finger 1	237	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein kinase binding|receptor binding|zinc ion binding				0			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		CGGGCGCGTTGAAGTCGCGCT	0.587		NaN											0	0	0	0.150653	0	3	4									
TRMT61B	55006	broad.mit.edu	37	2	29073986	29073986	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr2:29073986G>C	uc002rmm.2	-	5	1296	c.1264C>G	c.(1264-1266)CAA>GAA	p.Q422E	TRMT61B_uc002rmn.2_Missense_Mutation_p.Q422E|TRMT61B_uc010ezk.2_Intron	NM_017910	NP_060380	Q9BVS5	TR61B_HUMAN	tRNA methyltransferase 61 homolog B	422							tRNA (adenine-N1-)-methyltransferase activity				0						ATTTTCTCTTGAGAATCTAGT	0.363		NaN											0	0	0	0.108266	0	26	6									
PLEKHH2	130271	broad.mit.edu	37	2	43927132	43927132	+	Silent	SNP	A	A	G			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr2:43927132A>G	uc010yny.1	+	8	1118	c.1035A>G	c.(1033-1035)AGA>AGG	p.R345R	PLEKHH2_uc002rte.3_Silent_p.R345R|PLEKHH2_uc002rtf.3_Silent_p.R344R	NM_172069	NP_742066	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H	345						cytoplasm|cytoskeleton|integral to membrane	binding			skin(2)|central_nervous_system(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				GCATAAAGAGACCAGAACACA	0.428		NaN											0	0	0	0.105934	0	13	47									
ASXL1	171023	broad.mit.edu	37	20	31024350	31024350	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr20:31024350G>A	uc002wxs.2	+	12	4261	c.3835G>A	c.(3835-3837)GTG>ATG	p.V1279M	ASXL1_uc010geb.2_Missense_Mutation_p.V1170M	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	1279					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248						ATCTCCAAATGTGATCTCCTT	0.512		NaN	F|N|Mis		MDS|CMML								0	0	0	0.173368	0	36	26									
PHF20	51230	broad.mit.edu	37	20	34389477	34389477	+	Silent	SNP	C	C	T			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr20:34389477C>T	uc002xek.1	+	2	144	c.33C>T	c.(31-33)ATC>ATT	p.I11I	PHF20_uc002xei.1_Silent_p.I11I|PHF20_uc010gfo.1_Silent_p.I11I|PHF20_uc002xej.1_5'UTR|PHF20_uc002xeh.2_RNA	NM_016436	NP_057520	Q9BVI0	PHF20_HUMAN	PHD finger protein 20	11					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			ovary(1)	1	Breast(12;0.00631)|all_lung(11;0.0145)					GACGAGGAATCAGCTTTGAAG	0.398		NaN											0	0	0	0.11911	0	12	36									
PCK1	5105	broad.mit.edu	37	20	56137883	56137883	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr20:56137883G>A	uc002xyn.3	+	4	701	c.538G>A	c.(538-540)GTC>ATC	p.V180I	PCK1_uc010zzm.1_Intron	NM_002591	NP_002582	P35558	PCKGC_HUMAN	cytosolic phosphoenolpyruvate carboxykinase 1	180					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			skin(1)	1	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			GGGCACGCCCGTCCTGGAAGC	0.562		NaN											0	0	0	0.248553	0	5	37									
MRAP	56246	broad.mit.edu	37	21	33671325	33671325	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr21:33671325G>A	uc002ypj.2	+	3	230	c.43G>A	c.(43-45)GAA>AAA	p.E15K	MRAP_uc002ypk.2_Missense_Mutation_p.E15K|MRAP_uc011ado.1_Intron|MRAP_uc002ypl.2_Missense_Mutation_p.E15K	NM_178817	NP_848932	Q8TCY5	MRAP_HUMAN	melanocortin 2 receptor accessory protein	15	Cytoplasmic (Potential).				positive regulation of cAMP biosynthetic process|protein localization at cell surface	endoplasmic reticulum|integral to membrane|perinuclear region of cytoplasm|plasma membrane	corticotropin hormone receptor binding|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding|type 5 melanocortin receptor binding				0						CTACAGCTATGAATACTACCT	0.597		NaN											0	0	0	0.038147	0	7	28									
DSCAM	1826	broad.mit.edu	37	21	41452089	41452089	+	Silent	SNP	G	G	T			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr21:41452089G>T	uc002yyq.1	-	25	4862	c.4410C>A	c.(4408-4410)ACC>ACA	p.T1470T	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1470	Fibronectin type-III 5.|Extracellular (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CTTTTCCTAAGGTCTTTGCTT	0.428		NaN											1	0	0.00307968	0.038147	0.00314915	8	92									
COL18A1	80781	broad.mit.edu	37	21	46875522	46875522	+	Silent	SNP	G	G	C			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr21:46875522G>C	uc011afs.1	+	1	99	c.78G>C	c.(76-78)CTG>CTC	p.L26L	COL18A1_uc002zhg.2_Intron|COL18A1_uc002zhi.2_Silent_p.L26L	NM_130444	NP_569711	P39060	COIA1_HUMAN	alpha 1 type XVIII collagen isoform 3 precursor	26					cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			central_nervous_system(1)	1				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		CCAACCTGCTGAACCTGAACT	0.642		NaN											0	0	0	0.219247	0	20	92									
PCNT	5116	broad.mit.edu	37	21	47847643	47847643	+	Silent	SNP	C	C	T			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr21:47847643C>T	uc002zji.3	+	34	7535	c.7428C>T	c.(7426-7428)CTC>CTT	p.L2476L	PCNT_uc002zjj.2_Silent_p.L2358L	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	2476					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					AGCCCCGACTCAGTGGCTCAG	0.602		NaN											0	0	0	0.11911	0	14	71									
RBM9	23543	broad.mit.edu	37	22	36141976	36141976	+	Silent	SNP	G	G	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr22:36141976G>A	uc003aon.3	-	13	1417	c.1305C>T	c.(1303-1305)GGC>GGT	p.G435G	RBM9_uc003aog.3_Silent_p.G341G|RBM9_uc003aol.3_Silent_p.G360G|RBM9_uc003aoj.3_Silent_p.G364G|RBM9_uc003aok.3_Missense_Mutation_p.A348V|RBM9_uc003aoh.3_Missense_Mutation_p.A351V|RBM9_uc003aom.3_Silent_p.G342G|RBM9_uc010gwu.2_Missense_Mutation_p.A351V|RBM9_uc003aoo.3_Silent_p.G434G	NM_001082578	NP_001076047	O43251	RFOX2_HUMAN	RNA binding motif protein 9 isoform 5	374	Ala-rich.				estrogen receptor signaling pathway|mRNA processing|negative regulation of transcription, DNA-dependent|regulation of cell proliferation|RNA splicing	cytoplasm|nucleus	nucleotide binding|RNA binding|transcription corepressor activity|transcription factor binding				0						TTACCACAGCGCCAACTCCAT	0.443		NaN											0	0	0	0.219247	0	17	269									
CELSR1	9620	broad.mit.edu	37	22	46765614	46765614	+	Missense_Mutation	SNP	G	G	A	rs62226999		TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr22:46765614G>A	uc003bhw.1	-	26	7847	c.7847C>T	c.(7846-7848)GCG>GTG	p.A2616V	CELSR1_uc011arc.1_Silent_p.C1081C	NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	2616	Helical; Name=5; (Potential).				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		GATGGGCCCCGCAAAGCTCCA	0.622		NaN											0	0	0	0.217242	0	6	27									
ATP2B2	491	broad.mit.edu	37	3	10417249	10417249	+	Silent	SNP	C	C	T	rs113465029		TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr3:10417249C>T	uc003bvt.2	-	11	1720	c.1281G>A	c.(1279-1281)CCG>CCA	p.P427P	ATP2B2_uc003bvv.2_Silent_p.P382P|ATP2B2_uc003bvw.2_Silent_p.P382P|ATP2B2_uc010hdo.2_Silent_p.P132P	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	427	Extracellular (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						CAGGCAGCCACGGCTTCTTGT	0.577		NaN											0	0	0	0.132662	0	16	43									
CNTN3	5067	broad.mit.edu	37	3	74350837	74350837	+	Missense_Mutation	SNP	G	G	C	rs144093273	byFrequency	TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr3:74350837G>C	uc003dpm.1	-	14	1986	c.1906C>G	c.(1906-1908)CGG>GGG	p.R636G		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	636	Fibronectin type-III 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		AAAGGTGTCCGAGCCTGGATA	0.433		NaN											0	0	0	0.080935	0	11	32									
GPR156	165829	broad.mit.edu	37	3	119886517	119886517	+	Missense_Mutation	SNP	G	G	A	rs143524747	byFrequency	TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr3:119886517G>A	uc011bjf.1	-	9	1807	c.1807C>T	c.(1807-1809)CGG>TGG	p.R603W	GPR156_uc011bjg.1_Missense_Mutation_p.R599W	NM_153002	NP_694547	Q8NFN8	GP156_HUMAN	G protein-coupled receptor 156	603	Poly-Arg.|Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.19)		TGAGCTGCCCGCCTTCTCCTC	0.592		NaN											0	0	0	0.132662	0	16	43									
PLXNA1	5361	broad.mit.edu	37	3	126707544	126707544	+	Silent	SNP	T	T	G			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr3:126707544T>G	uc003ejg.2	+	1	43	c.39T>G	c.(37-39)GGT>GGG	p.G13G		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	36	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		CAGGCGGGGGTTCACAGCCCC	0.567		NaN											0	0	0	0.09319	0	8	17									
UGT2A3	79799	broad.mit.edu	37	4	69811101	69811101	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr4:69811101C>G	uc003hef.2	-	2	818	c.787G>C	c.(787-789)GAA>CAA	p.E263Q	UGT2A3_uc010ihp.1_RNA	NM_024743	NP_079019	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family,	263	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(1)|skin(1)	2						TGAGGAAATTCAAAATCCCAA	0.373		NaN											0	0	0	0.069234	0	11	37									
ANK2	287	broad.mit.edu	37	4	114280167	114280167	+	Nonsense_Mutation	SNP	G	G	T			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr4:114280167G>T	uc003ibe.3	+	38	10493	c.10393G>T	c.(10393-10395)GAG>TAG	p.E3465*	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Nonsense_Mutation_p.E767*|ANK2_uc011cgb.1_Nonsense_Mutation_p.E3480*	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	3432					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AGAAAGTAAGGAGCATTTCTT	0.458		NaN											1	0	9.31168e-06	0.105934	9.97156e-06	14	37									
FBXW7	55294	broad.mit.edu	37	4	153244232	153244232	+	Missense_Mutation	SNP	T	T	C			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08			T	C	T	T		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr4:153244232T>C	uc003ims.2	-	12	2074	c.1925A>G	c.(1924-1926)GAT>GGT	p.D642G	FBXW7_uc011cii.1_Missense_Mutation_p.D642G|FBXW7_uc003imt.2_Missense_Mutation_p.D642G|FBXW7_uc011cih.1_Missense_Mutation_p.D466G|FBXW7_uc003imq.2_Missense_Mutation_p.D562G|FBXW7_uc003imr.2_Missense_Mutation_p.D524G	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	642	WD 7.				interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding			haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				AGTTCCATCATCTGAGCTGGT	0.428		NaN	Mis|N|D|F		colorectal|endometrial|T-ALL								0	0	0	0.146539	0	16	59									
DDX4	54514	broad.mit.edu	37	5	55063741	55063741	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr5:55063741C>T	uc003jqg.3	+	7	441	c.367C>T	c.(367-369)CGG>TGG	p.R123W	DDX4_uc010ivz.2_Intron|DDX4_uc003jqh.3_Missense_Mutation_p.R123W|DDX4_uc003jqj.2_Missense_Mutation_p.R24W	NM_001136034	NP_001129506	Q9NQI0	DDX4_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform	123	Gly-rich.				multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|skin(1)	2		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)				TAATCCAACACGGAACAGAGG	0.333		NaN											0	0	0	0.11911	0	11	31									
GPR98	84059	broad.mit.edu	37	5	89923175	89923175	+	Nonsense_Mutation	SNP	G	G	T			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr5:89923175G>T	uc003kju.2	+	7	916	c.820G>T	c.(820-822)GAG>TAG	p.E274*	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	274	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TTTGGTTCCTGAGGAAGACCA	0.383		NaN											1	0	1.3612e-06	0.132662	1.50507e-06	13	67									
GPR98	84059	broad.mit.edu	37	5	89923397	89923397	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr5:89923397G>A	uc003kju.2	+	7	1138	c.1042G>A	c.(1042-1044)GAT>AAT	p.D348N	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	348	Calx-beta 3.|Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TCAAATAGTTGATGACACCAT	0.378		NaN											0	0	0	0.163468	0	32	97									
ANKRD32	84250	broad.mit.edu	37	5	94030836	94030836	+	Missense_Mutation	SNP	C	C	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr5:94030836C>A	uc003kkr.3	+	21	3076	c.2996C>A	c.(2995-2997)ACC>AAC	p.T999N	ANKRD32_uc003kks.2_Missense_Mutation_p.T363N	NM_032290	NP_115666	Q9BQI6	ANR32_HUMAN	ankyrin repeat domain 32	999										ovary(2)	2		all_cancers(142;1.51e-09)|all_epithelial(76;4.68e-12)|all_lung(232;5.94e-05)|Ovarian(174;0.000953)|Lung NSC(167;0.00105)|Colorectal(57;0.122)|Lung SC(612;0.152)		all cancers(79;3.88e-18)		CATAAAGAAACCACCAGTGTT	0.348		NaN											1	0	0.00307968	0.038147	0.00314915	5	57									
PCDHA5	56143	broad.mit.edu	37	5	140202795	140202795	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr5:140202795C>T	uc003lhl.2	+	1	1435	c.1435C>T	c.(1435-1437)CGG>TGG	p.R479W	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Missense_Mutation_p.R479W|PCDHA5_uc003lhj.1_Missense_Mutation_p.R479W	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	479	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGTCTGCACGGGACGCGGA	0.662		NaN											0	0	0	0.125774	0	28	37									
PCDHA9	9752	broad.mit.edu	37	5	140230125	140230125	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr5:140230125C>T	uc003lhu.2	+	1	2769	c.2045C>T	c.(2044-2046)GCG>GTG	p.A682V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Missense_Mutation_p.A682V	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	682	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCGTCGCGGGCGTCAGTGGGT	0.657		NaN											0	0	0	0.175082	0	19	27									
SQSTM1	8878	broad.mit.edu	37	5	179263552	179263552	+	Silent	SNP	C	C	T			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr5:179263552C>T	uc003mkw.3	+	8	1377	c.1282C>T	c.(1282-1284)CTG>TTG	p.L428L	SQSTM1_uc011dgr.1_Silent_p.L344L|SQSTM1_uc011dgs.1_Silent_p.L344L|SQSTM1_uc003mkv.3_Silent_p.L344L|SQSTM1_uc003mkx.2_Silent_p.L344L	NM_003900	NP_003891	Q13501	SQSTM_HUMAN	sequestosome 1 isoform 1	428	Interaction with NTRK1 (By similarity).|UBA.				anti-apoptosis|apoptosis|cell differentiation|endosome transport|induction of apoptosis by extracellular signals|intracellular signal transduction|macroautophagy|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein localization|regulation of I-kappaB kinase/NF-kappaB cascade|ubiquitin-dependent protein catabolic process	cytosol|late endosome|nucleoplasm	protein kinase C binding|receptor tyrosine kinase binding|SH2 domain binding|ubiquitin binding|zinc ion binding		SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(2)|ovary(1)	3	all_cancers(89;0.000205)|all_epithelial(37;7.15e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0395)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CGGAGCGGCTCTGGACACCAT	0.552		NaN							Paget_Disease_of_Bone				0	0	0	0.108266	0	24	60									
SLC17A3	10786	broad.mit.edu	37	6	25861865	25861865	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr6:25861865G>T	uc003nfi.3	-	4	488	c.378C>A	c.(376-378)AGC>AGA	p.S126R	SLC17A3_uc003nfk.3_Missense_Mutation_p.S204R|SLC17A3_uc011djz.1_Missense_Mutation_p.S204R|SLC17A3_uc011dka.1_Missense_Mutation_p.S126R	NM_006632	NP_006623	O00476	NPT4_HUMAN	solute carrier family 17 (sodium phosphate),	126	Helical; (Potential).				glucose-6-phosphate transport|urate metabolic process	apical plasma membrane|brush border membrane|endoplasmic reticulum membrane|integral to plasma membrane|perinuclear region of cytoplasm	drug transmembrane transporter activity|efflux transmembrane transporter activity|organic anion transmembrane transporter activity|sodium:phosphate symporter activity|toxin transporter activity|urate transmembrane transporter activity|voltage-gated anion channel activity				0						ATAAAGCAATGCTGCAGAGTC	0.418		NaN											1	0	1.66031e-10	0.0918	1.88168e-10	24	56									
KHDRBS2	202559	broad.mit.edu	37	6	62757854	62757854	+	Nonsense_Mutation	SNP	T	T	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr6:62757854T>A	uc003peg.2	-	3	512	c.265A>T	c.(265-267)AAG>TAG	p.K89*		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal	89	KH.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			skin(7)|ovary(3)|liver(1)	11				BRCA - Breast invasive adenocarcinoma(397;0.149)		TGTAGCCTCTTCAAGGAGTTT	0.353		NaN											0	0	0	0.204396	0	21	39									
B3GAT2	135152	broad.mit.edu	37	6	71665845	71665845	+	Silent	SNP	C	C	T			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr6:71665845C>T	uc003pfv.2	-	1	944	c.288G>A	c.(286-288)GCG>GCA	p.A96A	B3GAT2_uc011dxz.1_RNA|B3GAT2_uc003pfw.2_Silent_p.A96A	NM_080742	NP_542780	Q9NPZ5	B3GA2_HUMAN	beta-1,3-glucuronyltransferase 2	96	Lumenal (Potential).				carbohydrate biosynthetic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|metal ion binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						GGGTCAGCTCCGCTTTCTGCA	0.697		NaN											0	0	0	0.058154	0	7	16									
TMEM200A	114801	broad.mit.edu	37	6	130762085	130762085	+	Missense_Mutation	SNP	T	T	C			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr6:130762085T>C	uc003qca.2	+	3	1389	c.518T>C	c.(517-519)CTA>CCA	p.L173P	TMEM200A_uc010kfh.2_Missense_Mutation_p.L173P|TMEM200A_uc010kfi.2_Missense_Mutation_p.L173P|TMEM200A_uc003qcb.2_Missense_Mutation_p.L173P	NM_052913	NP_443145	Q86VY9	T200A_HUMAN	transmembrane protein 200A	173	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		ATTCACACGCTAAGAATCAAG	0.423		NaN											0	0	0	0.09319	0	10	29									
C7orf26	79034	broad.mit.edu	37	7	6634164	6634164	+	Silent	SNP	C	C	T			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr7:6634164C>T	uc003sqo.1	+	3	513	c.513C>T	c.(511-513)TTC>TTT	p.F171F	C7orf26_uc003sqp.1_Silent_p.F152F|C7orf26_uc003sqq.1_Intron	NM_024067	NP_076972	Q96N11	CG026_HUMAN	hypothetical protein LOC79034	171										ovary(1)	1		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)		AGCAGATATTCAGTGCCAGCC	0.502		NaN											0	0	0	0.058154	0	9	121									
SP4	6671	broad.mit.edu	37	7	21469484	21469484	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr7:21469484G>C	uc003sva.2	+	3	882	c.701G>C	c.(700-702)AGA>ACA	p.R234T	SP4_uc003svb.2_5'UTR	NM_003112	NP_003103	Q02446	SP4_HUMAN	Sp4 transcription factor	234					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(3)|skin(2)	5						GTCCAAATTAGACCTGGTGTT	0.443		NaN											0	0	0	0.132662	0	16	116									
ZNF92	168374	broad.mit.edu	37	7	64864186	64864186	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr7:64864186C>T	uc003ttz.2	+	4	1302	c.1159C>T	c.(1159-1161)CAT>TAT	p.H387Y	ZNF92_uc003tua.2_Missense_Mutation_p.H318Y|ZNF92_uc010kzu.2_Missense_Mutation_p.H355Y|ZNF92_uc003tub.2_Missense_Mutation_p.H311Y	NM_152626	NP_689839	Q03936	ZNF92_HUMAN	zinc finger protein 92 isoform 2	387	C2H2-type 9.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Lung NSC(55;0.159)				CCTTACTAAACATAAAAGAAT	0.358		NaN											0	0	0	0.175082	0	19	22									
SEMA3A	10371	broad.mit.edu	37	7	83591109	83591109	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr7:83591109G>C	uc003uhz.2	-	17	2209	c.1894C>G	c.(1894-1896)CAA>GAA	p.Q632E		NM_006080	NP_006071	Q14563	SEM3A_HUMAN	semaphorin 3A precursor	632	Ig-like C2-type.				axon guidance	extracellular region|membrane	receptor activity			ovary(2)|breast(1)|kidney(1)	4						AGAAGGCCTTGATCTGTCCTG	0.398		NaN											0	0	0	0.146539	0	17	21									
COL1A2	1278	broad.mit.edu	37	7	94043017	94043017	+	Missense_Mutation	SNP	G	G	A	rs147074348		TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr7:94043017G>A	uc003ung.1	+	27	2044	c.1573G>A	c.(1573-1575)GAT>AAT	p.D525N	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	525					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	TCCAGGTCCTGATGGAAACAA	0.453		NaN								HNSCC(75;0.22)			0	0	0	0.175082	0	16	25									
PSMC2	5701	broad.mit.edu	37	7	103007921	103007921	+	Silent	SNP	G	G	C			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr7:103007921G>C	uc003vbs.2	+	10	976	c.906G>C	c.(904-906)CTG>CTC	p.L302L	SLC26A5_uc003vbt.1_Intron|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|PSMC2_uc011klo.1_Silent_p.L165L	NM_002803	NP_002794	P35998	PRS7_HUMAN	proteasome 26S ATPase subunit 2	302					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding				0						TGTTGGAACTGATCAATCAGC	0.453		NaN											0	0	0	0.132662	0	14	55									
PSMC2	5701	broad.mit.edu	37	7	103007988	103007988	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr7:103007988G>A	uc003vbs.2	+	10	1043	c.973G>A	c.(973-975)GAT>AAT	p.D325N	SLC26A5_uc003vbt.1_Intron|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|PSMC2_uc011klo.1_Missense_Mutation_p.D188N	NM_002803	NP_002794	P35998	PRS7_HUMAN	proteasome 26S ATPase subunit 2	325					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding				0						TAACAGACCTGATACTTTGGA	0.403		NaN											0	0	0	0.080935	0	11	48									
PSMC2	5701	broad.mit.edu	37	7	103008039	103008039	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr7:103008039G>A	uc003vbs.2	+	10	1094	c.1024G>A	c.(1024-1026)GAA>AAA	p.E342K	SLC26A5_uc003vbt.1_Intron|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|PSMC2_uc011klo.1_Missense_Mutation_p.E205K	NM_002803	NP_002794	P35998	PRS7_HUMAN	proteasome 26S ATPase subunit 2	342					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding				0						TAGAAAAATTGAATTTAGCTT	0.358		NaN											0	0	0	0.09319	0	13	44									
PSMC2	5701	broad.mit.edu	37	7	103008218	103008218	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr7:103008218G>A	uc003vbs.2	+	11	1176	c.1106G>A	c.(1105-1107)AGA>AAA	p.R369K	SLC26A5_uc003vbt.1_Intron|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|PSMC2_uc011klo.1_Missense_Mutation_p.R232K	NM_002803	NP_002794	P35998	PRS7_HUMAN	proteasome 26S ATPase subunit 2	369					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding				0						AGAGATATCAGATTTGAACTG	0.363		NaN											0	0	0	0.189662	0	19	57									
PSMC2	5701	broad.mit.edu	37	7	103008346	103008346	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr7:103008346G>A	uc003vbs.2	+	12	1217	c.1147G>A	c.(1147-1149)GCT>ACT	p.A383T	SLC26A5_uc003vbt.1_Intron|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|PSMC2_uc011klo.1_Missense_Mutation_p.A246T	NM_002803	NP_002794	P35998	PRS7_HUMAN	proteasome 26S ATPase subunit 2	383					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding				0						TTTGAAAGGTGCTGAGATTAG	0.413		NaN											0	0	0	0.146539	0	17	65									
PSMC2	5701	broad.mit.edu	37	7	103008392	103008392	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr7:103008392G>A	uc003vbs.2	+	12	1263	c.1193G>A	c.(1192-1194)AGA>AAA	p.R398K	SLC26A5_uc003vbt.1_Intron|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|PSMC2_uc011klo.1_Missense_Mutation_p.R261K	NM_002803	NP_002794	P35998	PRS7_HUMAN	proteasome 26S ATPase subunit 2	398					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding				0						TTTGCCATCAGAGCACGGCGA	0.423		NaN											0	0	0	0.146539	0	16	77									
PSMC2	5701	broad.mit.edu	37	7	103008417	103008417	+	Silent	SNP	G	G	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr7:103008417G>A	uc003vbs.2	+	12	1288	c.1218G>A	c.(1216-1218)GAG>GAA	p.E406E	SLC26A5_uc003vbt.1_Intron|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|PSMC2_uc011klo.1_Silent_p.E269E	NM_002803	NP_002794	P35998	PRS7_HUMAN	proteasome 26S ATPase subunit 2	406					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding				0						TTGCTACCGAGAAGGATTTCT	0.423		NaN											0	0	0	0.146539	0	17	66									
CTHRC1	115908	broad.mit.edu	37	8	104388121	104388121	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr8:104388121G>A	uc003ylk.2	+	2	405	c.306G>A	c.(304-306)TGG>TGA	p.W102*	CTHRC1_uc011lhq.1_Nonsense_Mutation_p.W102*	NM_138455	NP_612464	Q96CG8	CTHR1_HUMAN	collagen triple helix repeat containing 1	102						collagen				ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(57;2.79e-06)|STAD - Stomach adenocarcinoma(118;0.197)			AGGAGTCCTGGACACCCAACT	0.453		NaN											0	0	0	0.058154	0	10	64									
ZFP37	7539	broad.mit.edu	37	9	115806366	115806366	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr9:115806366C>G	uc004bgm.1	-	4	560	c.532G>C	c.(532-534)GAG>CAG	p.E178Q	ZFP37_uc011lwz.1_Missense_Mutation_p.E193Q|ZFP37_uc011lxa.1_Missense_Mutation_p.E179Q	NM_003408	NP_003399	Q9Y6Q3	ZFP37_HUMAN	zinc finger protein 37 homolog	178						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						CCACATGACTCAAATTTAAGA	0.333		NaN											0	0	0	0.047766	0	9	38									
PAPPA	5069	broad.mit.edu	37	9	118982346	118982346	+	Silent	SNP	C	C	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr9:118982346C>A	uc004bjn.2	+	5	2430	c.2049C>A	c.(2047-2049)GGC>GGA	p.G683G	PAPPA_uc011lxp.1_Silent_p.G378G|PAPPA_uc011lxq.1_Intron	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	683					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						AAGTTCTGGGCCACACAACGG	0.562		NaN											1	0	2.6416e-12	0.235728	3.07058e-12	37	57									
GPR21	2844	broad.mit.edu	37	9	125797575	125797575	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr9:125797575G>A	uc011lzk.1	+	1	730	c.730G>A	c.(730-732)GCC>ACC	p.A244T	RABGAP1_uc004bnl.3_Intron|RABGAP1_uc011lzh.1_Intron|RABGAP1_uc011lzj.1_Intron|GPR21_uc011lzi.1_RNA	NM_005294	NP_005285	Q99679	GPR21_HUMAN	G protein-coupled receptor 21	244	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)	1						GGAAGTGCAGGCCTGTCCTGA	0.488		NaN											0	0	0	0.219247	0	20	61									
ARSD	414	broad.mit.edu	37	X	2825476	2825476	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chrX:2825476C>T	uc004cqy.2	-	10	1694	c.1618G>A	c.(1618-1620)GTG>ATG	p.V540M	ARSD_uc004cqz.1_RNA	NM_001669	NP_001660	P51689	ARSD_HUMAN	arylsulfatase D isoform a precursor	540						lysosome	arylsulfatase activity|metal ion binding				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CTTGCTATCACGGCGTGGTAC	0.647		NaN											0	0	0	0.150653	0	4	10									
DMD	1756	broad.mit.edu	37	X	32235148	32235148	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chrX:32235148C>T	uc004dda.1	-	44	6567	c.6323G>A	c.(6322-6324)CGT>CAT	p.R2108H	DMD_uc004dcw.2_Missense_Mutation_p.R764H|DMD_uc004dcx.2_Missense_Mutation_p.R767H|DMD_uc004dcz.2_Missense_Mutation_p.R1985H|DMD_uc004dcy.1_Missense_Mutation_p.R2104H|DMD_uc004ddb.1_Missense_Mutation_p.R2100H|DMD_uc010ngo.1_Missense_Mutation_p.R17H|DMD_uc010ngn.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2108	Spectrin 15.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				ATAATGAAAACGCCGCCATTT	0.348		NaN											0	0	0	0.11911	0	13	11									
KIAA1210	57481	broad.mit.edu	37	X	118223492	118223492	+	Silent	SNP	G	G	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chrX:118223492G>A	uc004era.3	-	11	1701	c.1701C>T	c.(1699-1701)GGC>GGT	p.G567G		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	567										ovary(4)|skin(1)	5						CAGCTCTATCGCCCAGGCCAT	0.473		NaN											0	0	0	0.108266	0	28	47									
ILDR2	387597	broad.mit.edu	37	1	166889977	166889979	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr1:166889977_166889979delCTC	uc001gdx.1	-	9	1905_1907	c.1849_1851delGAG	c.(1849-1851)GAGdel	p.E617del		NM_199351	NP_955383	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor	617	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1						TCCTCTTCTTCTCCGAGTTGCTG	0.685		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---	---							
OR2M3	127062	broad.mit.edu	37	1	248366372	248366372	+	Frame_Shift_Del	DEL	G	G	-			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr1:248366372delG	uc010pzg.1	+	1	3	c.3delG	c.(1-3)ATGfs	p.M1fs		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	1	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TACACATCATGGCAAGGGAGA	0.438		NaN											NaN	NaN	NaN	NaN	NaN	41	149	---	---							
PABPC3	5042	broad.mit.edu	37	13	25671333	25671333	+	Frame_Shift_Del	DEL	A	A	-			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr13:25671333delA	uc001upy.2	+	1	1058	c.997delA	c.(997-999)AAAfs	p.K333fs		NM_030979	NP_112241	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	333	RRM 4.				mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			ovary(3)|skin(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		TGGTCGCAGCAAAGGGTTTGG	0.428		NaN											NaN	NaN	NaN	NaN	NaN	12	153	---	---							
CREBBP	1387	broad.mit.edu	37	16	3828084	3828085	+	Frame_Shift_Ins	INS	-	-	C			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr16:3828084_3828085insC	uc002cvv.2	-	10	2244_2245	c.2040_2041insG	c.(2038-2043)GGGAACfs	p.G680fs	CREBBP_uc002cvw.2_Frame_Shift_Ins_p.G642fs	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	680_681					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		GCTGGCTGGTTCCCCAAGATGC	0.46		NaN	T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				NaN	NaN	NaN	NaN	NaN	39	108	---	---							
EFCAB5	374786	broad.mit.edu	37	17	28296048	28296049	+	Frame_Shift_Ins	INS	-	-	A			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr17:28296048_28296049insA	uc002het.2	+	4	622_623	c.430_431insA	c.(430-432)GAAfs	p.E144fs	EFCAB5_uc010wbi.1_Intron|EFCAB5_uc010wbj.1_Frame_Shift_Ins_p.E88fs|EFCAB5_uc010wbk.1_Intron|EFCAB5_uc010csd.2_RNA|EFCAB5_uc010cse.2_Frame_Shift_Ins_p.E23fs|EFCAB5_uc010csf.2_Frame_Shift_Ins_p.E23fs	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	144							calcium ion binding			ovary(1)|skin(1)	2						GAAGGAACTAGAAAAAAAGGCT	0.366		NaN											NaN	NaN	NaN	NaN	NaN	6	8	---	---							
SCARF2	91179	broad.mit.edu	37	22	20785803	20785803	+	Frame_Shift_Del	DEL	C	C	-			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr22:20785803delC	uc002zsj.1	-	4	461	c.356delG	c.(355-357)GGCfs	p.G119fs	SCARF2_uc002zsk.1_Frame_Shift_Del_p.G119fs	NM_153334	NP_699165	Q96GP6	SREC2_HUMAN	scavenger receptor class F, member 2 isoform 1	119	Extracellular (Potential).				cell adhesion	integral to membrane	protein binding|receptor activity			breast(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			GCAGTCGGGGCCCCAGAACTG	0.716		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---	---							
HIST1H2BO	8348	broad.mit.edu	37	6	27861467	27861477	+	Frame_Shift_Del	DEL	GCGAGGCTTCC	GCGAGGCTTCC	-	rs142034002	byFrequency	TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr6:27861467_27861477delGCGAGGCTTCC	uc003nkc.1	+	1	265_275	c.227_237delGCGAGGCTTCC	c.(226-237)GGCGAGGCTTCCfs	p.G76fs	HIST1H3J_uc003nka.2_5'Flank|HIST1H2AM_uc003nkb.1_5'Flank	NM_003527	NP_003518	P23527	H2B1O_HUMAN	histone cluster 1, H2bo	76_79					nucleosome assembly	nucleosome|nucleus	DNA binding				0						CGCATCGCTGGCGAGGCTTCCCGCCTGGCGC	0.616		NaN											NaN	NaN	NaN	NaN	NaN	28	67	---	---							
IGF2R	3482	broad.mit.edu	37	6	160500714	160500721	+	Frame_Shift_Del	DEL	ACCAAGGG	ACCAAGGG	-			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr6:160500714_160500721delACCAAGGG	uc003qta.2	+	38	5729_5736	c.5581_5588delACCAAGGG	c.(5581-5589)ACCAAGGGGfs	p.T1861fs		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	1861_1863	13.|Lumenal (Potential).				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		GCTCTCAGGCACCAAGGGGGCATCCTTT	0.562		NaN											NaN	NaN	NaN	NaN	NaN	8	21	---	---							
ACTL6B	51412	broad.mit.edu	37	7	100252715	100252716	+	Frame_Shift_Ins	INS	-	-	T			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr7:100252715_100252716insT	uc003uvy.2	-	4	402_403	c.295_296insA	c.(295-297)ATCfs	p.I99fs	ACTL6B_uc003uvz.2_RNA|uc003uwa.1_5'Flank	NM_016188	NP_057272	O94805	ACL6B_HUMAN	actin-like 6B	99					chromatin modification|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nBAF complex|SWI/SNF complex	ATP binding|protein binding|structural constituent of cytoskeleton			ovary(1)	1	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					GTGATCCAGGATGGCTCGGAAG	0.599		NaN											NaN	NaN	NaN	NaN	NaN	9	30	---	---							
CUL4B	8450	broad.mit.edu	37	X	119679350	119679350	+	Frame_Shift_Del	DEL	A	A	-			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chrX:119679350delA	uc004esw.2	-	7	1360	c.923delT	c.(922-924)TTGfs	p.L308fs	CUL4B_uc010nqq.2_Frame_Shift_Del_p.L7fs|CUL4B_uc004esv.2_Frame_Shift_Del_p.L290fs	NM_003588	NP_003579	Q13620	CUL4B_HUMAN	cullin 4B isoform 1	308					cell cycle|DNA repair|ubiquitin-dependent protein catabolic process	Cul4B-RING ubiquitin ligase complex|nucleus	protein binding|ubiquitin protein ligase binding			lung(1)|central_nervous_system(1)|pancreas(1)	3						ATCCAGAAACAAAAAAATGCT	0.308		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---	---