Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
H6PD	9563	broad.mit.edu	37	1	9324107	9324107	+	Missense_Mutation	SNP	C	C	T	rs35863691	byFrequency	TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:9324107C>T	uc001apt.2	+	5	1828	c.1555C>T	c.(1555-1557)CGG>TGG	p.R519W		NM_004285	NP_004276	O95479	G6PE_HUMAN	hexose-6-phosphate dehydrogenase precursor	519	Glucose 1-dehydrogenase.					endoplasmic reticulum lumen	6-phosphogluconolactonase activity|glucose 1-dehydrogenase|glucose-6-phosphate dehydrogenase activity|NADP binding				0	all_lung(157;0.23)	all_epithelial(116;1.28e-19)|all_lung(118;5.22e-06)|Lung NSC(185;1.98e-05)|Renal(390;0.000147)|Breast(348;0.00109)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.88e-07)|COAD - Colon adenocarcinoma(227;7.47e-05)|Kidney(185;0.000244)|KIRC - Kidney renal clear cell carcinoma(229;0.000905)|STAD - Stomach adenocarcinoma(132;0.00176)|BRCA - Breast invasive adenocarcinoma(304;0.00183)|READ - Rectum adenocarcinoma(331;0.0419)	NADH(DB00157)	CAGTAGCGGCCGGTTGTTCTT	0.637		NaN											0	0	0	0.00278	0	23	233									
PLA2G2A	5320	broad.mit.edu	37	1	20302318	20302318	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:20302318C>T	uc001bcu.2	-	5	529	c.311G>A	c.(310-312)AGA>AAA	p.R104K	PLA2G2A_uc001bcv.2_Missense_Mutation_p.R104K|PLA2G2A_uc010oda.1_Missense_Mutation_p.R104K|PLA2G2A_uc010odb.1_Missense_Mutation_p.R104K	NM_001161729	NP_001155201	P14555	PA2GA_HUMAN	phospholipase A2, group IIA precursor	104					defense response to Gram-positive bacterium|lipid catabolic process|low-density lipoprotein particle remodeling|phosphatidic acid metabolic process|positive regulation of inflammatory response|positive regulation of macrophage derived foam cell differentiation	endoplasmic reticulum|extracellular space|membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|phospholipid binding				0		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00459)|Lung NSC(340;0.00475)|Breast(348;0.00526)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|COAD - Colon adenocarcinoma(152;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000138)|Kidney(64;0.000171)|GBM - Glioblastoma multiforme(114;0.00032)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CAGTTGACTTCTGCAGGAGTC	0.398		NaN											0	0	0	0.008291	0	10	39									
KIF2C	11004	broad.mit.edu	37	1	45226006	45226006	+	Silent	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:45226006C>T	uc001cmg.3	+	15	1537	c.1422C>T	c.(1420-1422)TTC>TTT	p.F474F	KIF2C_uc010olb.1_Silent_p.F433F|KIF2C_uc010olc.1_Silent_p.F361F|KIF2C_uc001cmh.3_Silent_p.F420F	NM_006845	NP_006836	Q99661	KIF2C_HUMAN	kinesin family member 2C	474	Kinesin-motor.				blood coagulation|cell division|cell proliferation|chromosome segregation|establishment or maintenance of microtubule cytoskeleton polarity|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|kinesin complex|microtubule|nucleus	ATP binding|centromeric DNA binding|microtubule motor activity|microtubule plus-end binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					ACGCGTGCTTCCAAATTATTC	0.527		NaN											0	0	0	0.003755	0	33	23									
ZCCHC11	23318	broad.mit.edu	37	1	52941116	52941116	+	Silent	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:52941116C>T	uc001ctx.2	-	13	2349	c.2115G>A	c.(2113-2115)CGG>CGA	p.R705R	ZCCHC11_uc001cty.2_Silent_p.R705R|ZCCHC11_uc001ctz.2_Silent_p.R705R|ZCCHC11_uc009vze.1_Silent_p.R705R|ZCCHC11_uc009vzf.1_Silent_p.R464R|ZCCHC11_uc001cub.2_Silent_p.R705R	NM_015269	NP_056084	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11 isoform	705					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)|skin(1)	3						AGGCAAAATACCGATAAGCTG	0.418		NaN											0	0	0	0.007413	0	19	55									
GBP4	115361	broad.mit.edu	37	1	89661003	89661003	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:89661003C>T	uc001dnb.2	-	3	456	c.340G>A	c.(340-342)GAG>AAG	p.E114K		NM_052941	NP_443173	Q96PP9	GBP4_HUMAN	guanylate binding protein 4	114	GTP (By similarity).					cytoplasm	GTP binding|GTPase activity				0				all cancers(265;0.00723)|Epithelial(280;0.0291)		CCCAGGCCCTCGGTGTCCAGA	0.522		NaN											0	0	0	0.01441	0	55	111									
SLC44A3	126969	broad.mit.edu	37	1	95360474	95360474	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:95360474G>C	uc001dqv.3	+	15	2065	c.1958G>C	c.(1957-1959)AGA>ACA	p.R653T	SLC44A3_uc001dqx.3_Missense_Mutation_p.R652T|SLC44A3_uc010otq.1_Missense_Mutation_p.R585T|SLC44A3_uc010otr.1_Missense_Mutation_p.R617T|SLC44A3_uc001dqw.3_Missense_Mutation_p.R605T|SLC44A3_uc010ots.1_Missense_Mutation_p.R573T|SLC44A3_uc009wds.2_Missense_Mutation_p.R556T|SLC44A3_uc010ott.1_Missense_Mutation_p.R572T	NM_001114106	NP_001107578	Q8N4M1	CTL3_HUMAN	solute carrier family 44, member 3 isoform 1	653						integral to membrane|plasma membrane	choline transmembrane transporter activity			kidney(1)	1		all_lung(203;0.000712)|Lung NSC(277;0.00316)		all cancers(265;0.039)|Epithelial(280;0.124)	Choline(DB00122)	GCCATTGTGAGATAGATACCC	0.393		NaN											0	0	0	0.00632	0	23	40									
OLFM3	118427	broad.mit.edu	37	1	102271652	102271652	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:102271652C>G	uc001duf.2	-	5	810	c.739G>C	c.(739-741)GCA>CCA	p.A247P	OLFM3_uc001dug.2_Missense_Mutation_p.A227P|OLFM3_uc001duh.2_RNA|OLFM3_uc001dui.2_RNA|OLFM3_uc001duj.2_Missense_Mutation_p.A152P|OLFM3_uc001due.2_RNA	NM_058170	NP_477518	Q96PB7	NOE3_HUMAN	olfactomedin 3	247	Olfactomedin-like.					extracellular region				ovary(2)|skin(1)	3		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		TTCTCAGATGCTAAAGGGTCT	0.398		NaN											0	0	0	0.007413	0	15	135									
WDR47	22911	broad.mit.edu	37	1	109538452	109538452	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:109538452G>C	uc001dwj.2	-	8	1817	c.1441C>G	c.(1441-1443)CAA>GAA	p.Q481E	WDR47_uc001dwl.2_Missense_Mutation_p.Q489E|WDR47_uc001dwi.2_Missense_Mutation_p.Q482E|WDR47_uc001dwk.2_Missense_Mutation_p.Q453E|WDR47_uc010ovf.1_Missense_Mutation_p.Q408E	NM_001142551	NP_001136023	O94967	WDR47_HUMAN	WD repeat domain 47 isoform 3	481										ovary(1)	1		all_lung(203;0.00519)|all_epithelial(167;0.00611)|Lung NSC(277;0.00822)		Colorectal(144;0.0165)|Lung(183;0.0484)|COAD - Colon adenocarcinoma(174;0.128)|Epithelial(280;0.168)|all cancers(265;0.201)|LUSC - Lung squamous cell carcinoma(189;0.244)		CCAAGCTTTTGAATGGACCTA	0.313		NaN											0	0	0	0.00278	0	24	78									
KCND3	3752	broad.mit.edu	37	1	112525046	112525046	+	Silent	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:112525046C>T	uc001ebu.1	-	2	783	c.303G>A	c.(301-303)GGG>GGA	p.G101G	KCND3_uc001ebv.1_Silent_p.G101G	NM_004980	NP_004971	Q9UK17	KCND3_HUMAN	potassium voltage-gated channel, Shal-related	101	Cytoplasmic (Potential).					sarcolemma|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|metal ion binding			ovary(2)|large_intestine(1)	3		all_cancers(81;8.52e-06)|all_epithelial(167;5.65e-06)|all_lung(203;2.72e-05)|Lung NSC(69;4.56e-05)		all cancers(265;0.056)|Lung(183;0.0576)|Colorectal(144;0.1)|Epithelial(280;0.104)|COAD - Colon adenocarcinoma(174;0.222)|LUSC - Lung squamous cell carcinoma(189;0.231)		AGTGCAGCTTCCCCGTGCGGT	0.607		NaN											0	0	0	0.003755	0	30	139									
ATP1A1	476	broad.mit.edu	37	1	116932065	116932065	+	Silent	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:116932065C>T	uc001ege.2	+	8	1098	c.759C>T	c.(757-759)ACC>ACT	p.T253T	ATP1A1_uc010owv.1_Silent_p.T222T|ATP1A1_uc010oww.1_Silent_p.T253T|ATP1A1_uc010owx.1_Silent_p.T222T	NM_000701	NP_000692	P05023	AT1A1_HUMAN	Na+/K+ -ATPase alpha 1 subunit isoform a	253	Cytoplasmic (Potential).				ATP biosynthetic process	melanosome|sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|protein binding|sodium:potassium-exchanging ATPase activity			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;1.28e-06)|all_epithelial(167;3.48e-07)|all_lung(203;2.64e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0164)|LUSC - Lung squamous cell carcinoma(189;0.0548)|Colorectal(144;0.0825)|COAD - Colon adenocarcinoma(174;0.127)|all cancers(265;0.24)	Acetyldigitoxin(DB00511)|Almitrine(DB01430)|Aluminium(DB01370)|Bepridil(DB01244)|Bretylium(DB01158)|Captopril(DB01197)|Deslanoside(DB01078)|Diazoxide(DB01119)|Digitoxin(DB01396)|Digoxin(DB00390)|Esomeprazole(DB00736)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Ouabain(DB01092)|Pantoprazole(DB00213)|Trichlormethiazide(DB01021)	TTTAAGGCACCGCACGTGGTA	0.473		NaN											0	0	0	0.01441	0	46	193									
ATP1A1	476	broad.mit.edu	37	1	116932235	116932235	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:116932235C>G	uc001ege.2	+	8	1268	c.929C>G	c.(928-930)TCT>TGT	p.S310C	ATP1A1_uc010owv.1_Missense_Mutation_p.S279C|ATP1A1_uc010oww.1_Missense_Mutation_p.S310C|ATP1A1_uc010owx.1_Missense_Mutation_p.S279C	NM_000701	NP_000692	P05023	AT1A1_HUMAN	Na+/K+ -ATPase alpha 1 subunit isoform a	310	Extracellular (Potential).				ATP biosynthetic process	melanosome|sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|protein binding|sodium:potassium-exchanging ATPase activity			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;1.28e-06)|all_epithelial(167;3.48e-07)|all_lung(203;2.64e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0164)|LUSC - Lung squamous cell carcinoma(189;0.0548)|Colorectal(144;0.0825)|COAD - Colon adenocarcinoma(174;0.127)|all cancers(265;0.24)	Acetyldigitoxin(DB00511)|Almitrine(DB01430)|Aluminium(DB01370)|Bepridil(DB01244)|Bretylium(DB01158)|Captopril(DB01197)|Deslanoside(DB01078)|Diazoxide(DB01119)|Digitoxin(DB01396)|Digoxin(DB00390)|Esomeprazole(DB00736)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Ouabain(DB01092)|Pantoprazole(DB00213)|Trichlormethiazide(DB01021)	TTCATCCTTTCTCTCATCCTT	0.507		NaN											0	0	0	0.007413	0	16	56									
TARS2	80222	broad.mit.edu	37	1	150459941	150459941	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:150459941G>C	uc001euq.2	+	1	22	c.15G>C	c.(13-15)CAG>CAC	p.Q5H	TARS2_uc010pcd.1_RNA|TARS2_uc001eur.2_Missense_Mutation_p.Q5H|TARS2_uc009wlt.2_5'UTR|TARS2_uc009wls.2_Missense_Mutation_p.Q5H	NM_025150	NP_079426	Q9BW92	SYTM_HUMAN	threonyl-tRNA synthetase 2, mitochondrial	5					threonyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|threonine-tRNA ligase activity			ovary(1)	1	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.51e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)		L-Threonine(DB00156)	CCCTGTATCAGAGGTGGCGGT	0.552		NaN											0	0	0	0.004656	0	21	225									
TARS2	80222	broad.mit.edu	37	1	150460385	150460385	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:150460385G>A	uc001euq.2	+	2	125	c.118G>A	c.(118-120)GAG>AAG	p.E40K	TARS2_uc010pcd.1_RNA|TARS2_uc001eur.2_Missense_Mutation_p.E40K|TARS2_uc009wlt.2_5'UTR|TARS2_uc009wls.2_Missense_Mutation_p.E40K	NM_025150	NP_079426	Q9BW92	SYTM_HUMAN	threonyl-tRNA synthetase 2, mitochondrial	40					threonyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|threonine-tRNA ligase activity			ovary(1)	1	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.51e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)		L-Threonine(DB00156)	TGGCCTTTTTGAGGAGCTGTG	0.507		NaN											0	0	0	0.007835	0	38	263									
TARS2	80222	broad.mit.edu	37	1	150463886	150463886	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:150463886G>C	uc001euq.2	+	5	536	c.529G>C	c.(529-531)GAG>CAG	p.E177Q	TARS2_uc010pcd.1_RNA|TARS2_uc001eur.2_Missense_Mutation_p.E177Q|TARS2_uc009wlt.2_Intron|TARS2_uc009wls.2_Missense_Mutation_p.E177Q	NM_025150	NP_079426	Q9BW92	SYTM_HUMAN	threonyl-tRNA synthetase 2, mitochondrial	177					threonyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|threonine-tRNA ligase activity			ovary(1)	1	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.51e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)		L-Threonine(DB00156)	CCGGGGCTCAGAGCTGCCTGT	0.552		NaN											0	0	0	0.004289	0	34	254									
ADAMTSL4	54507	broad.mit.edu	37	1	150532263	150532263	+	Silent	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:150532263G>A	uc001eux.2	+	18	3206	c.2970G>A	c.(2968-2970)ACG>ACA	p.T990T	ADAMTSL4_uc009wlw.2_Silent_p.T1013T|ADAMTSL4_uc010pcg.1_Silent_p.T951T|ADAMTSL4_uc009wlx.2_Silent_p.T153T	NM_019032	NP_061905	Q6UY14	ATL4_HUMAN	thrombospondin repeat containing 1 isoform 1	990	TSP type-1 6.				apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding			ovary(1)|skin(1)	2	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			AAGGGGGAACGCAGACACGGG	0.637		NaN									OREG0013787	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010818	0	28	533									
PIP5K1A	8394	broad.mit.edu	37	1	151205150	151205150	+	Missense_Mutation	SNP	C	C	G	rs148159537	byFrequency	TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:151205150C>G	uc001exj.2	+	7	1062	c.610C>G	c.(610-612)CTG>GTG	p.L204V	PIP5K1A_uc001exi.2_Missense_Mutation_p.L191V|PIP5K1A_uc010pcu.1_Missense_Mutation_p.L192V|PIP5K1A_uc001exk.2_Missense_Mutation_p.L191V|PIP5K1A_uc010pcv.1_5'Flank	NM_001135638	NP_001129110	Q99755	PI51A_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	204	PIPK.				phospholipid biosynthetic process|signal transduction	endomembrane system|Golgi stack|lamellipodium|nuclear speck	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|kinase binding			ovary(1)|central_nervous_system(1)|skin(1)	3	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.181)			GGCGGAATTTCTGCAGAAGCT	0.498		NaN											0	0	0	0.003954	0	19	152									
FLG	2312	broad.mit.edu	37	1	152280743	152280743	+	Missense_Mutation	SNP	C	C	G	rs71625185		TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:152280743C>G	uc001ezu.1	-	3	6655	c.6619G>C	c.(6619-6621)GGG>CGG	p.G2207R		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2207	Ser-rich.|Filaggrin 13.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGATGCGACCCTGAGTGCCTA	0.572		NaN							Ichthyosis				0	0	0	0.009535	0	29	572									
FLG	2312	broad.mit.edu	37	1	152286605	152286605	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:152286605C>G	uc001ezu.1	-	3	793	c.757G>C	c.(757-759)GAA>CAA	p.E253Q	uc001ezv.2_Intron	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	253					keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATTTTGTTTTCTTCTAATAGA	0.378		NaN							Ichthyosis				0	0	0	0.01441	0	68	381									
FLG	2312	broad.mit.edu	37	1	152287125	152287125	+	Silent	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:152287125G>A	uc001ezu.1	-	3	273	c.237C>T	c.(235-237)TTC>TTT	p.F79F	uc001ezv.2_RNA	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	79	EF-hand 2.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGCCAACTTGAATACCATCA	0.378		NaN							Ichthyosis				0	0	0	0.004656	0	26	174									
FCRL2	79368	broad.mit.edu	37	1	157738266	157738266	+	Missense_Mutation	SNP	T	T	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:157738266T>A	uc001fre.2	-	5	880	c.821A>T	c.(820-822)TAC>TTC	p.Y274F	FCRL2_uc001frd.2_5'Flank|FCRL2_uc010phz.1_Missense_Mutation_p.Y274F|FCRL2_uc009wsp.2_Intron	NM_030764	NP_110391	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2 precursor	274	Ig-like C2-type 3.|Extracellular (Potential).				cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity			ovary(1)|pancreas(1)	2	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			AGCTCTACAGTAATATTTGCC	0.498		NaN											0	0	0	0.00245	0	14	169									
XPR1	9213	broad.mit.edu	37	1	180775611	180775611	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:180775611C>T	uc001goi.2	+	6	791	c.599C>T	c.(598-600)GCT>GTT	p.A200V	XPR1_uc009wxm.2_Missense_Mutation_p.A200V|XPR1_uc009wxn.2_Missense_Mutation_p.A200V	NM_004736	NP_004727	Q9UBH6	XPR1_HUMAN	xenotropic and polytropic retrovirus receptor	200	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity				0						TCTTTCTAGGCTGTAGTGACC	0.368		NaN											0	0	0	0.005443	0	22	69									
CFHR2	3080	broad.mit.edu	37	1	196920122	196920122	+	Missense_Mutation	SNP	C	C	T	rs111586074		TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:196920122C>T	uc001gtq.1	+	3	471	c.394C>T	c.(394-396)CGG>TGG	p.R132W	CFHR2_uc001gtr.1_Intron	NM_005666	NP_005657	P36980	FHR2_HUMAN	H factor (complement)-like 3 precursor	132	Sushi 2.					extracellular region				skin(2)|ovary(1)	3						ATGTGTAGAACGGGGCTGGTC	0.373		NaN											0	0	0	0.01441	0	57	39									
RPS6KC1	26750	broad.mit.edu	37	1	213414318	213414318	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:213414318C>G	uc010ptr.1	+	11	1658	c.1499C>G	c.(1498-1500)TCT>TGT	p.S500C	RPS6KC1_uc001hkd.2_Missense_Mutation_p.S488C|RPS6KC1_uc010pts.1_Missense_Mutation_p.S288C|RPS6KC1_uc010ptt.1_Missense_Mutation_p.S288C|RPS6KC1_uc010ptu.1_Missense_Mutation_p.S319C|RPS6KC1_uc010ptv.1_Missense_Mutation_p.S35C|RPS6KC1_uc001hke.2_Missense_Mutation_p.S319C	NM_012424	NP_036556	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide	500					cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(3)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		TGGCCAGATTCTGGTTCAAGT	0.413		NaN											0	0	0	0.00278	0	19	34									
CENPF	1063	broad.mit.edu	37	1	214820493	214820493	+	Missense_Mutation	SNP	T	T	C			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:214820493T>C	uc001hkm.2	+	13	7754	c.7580T>C	c.(7579-7581)CTG>CCG	p.L2527P		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	2623	Potential.|Sufficient for self-association.|Sufficient for centromere localization.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		ATCAGTAGACTGAAAAATCAA	0.388		NaN											0	0	0	0.000602	0	4	56									
EXOC8	149371	broad.mit.edu	37	1	231472540	231472540	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:231472540C>T	uc001huq.2	-	1	1039	c.952G>A	c.(952-954)GAA>AAA	p.E318K		NM_175876	NP_787072	Q8IYI6	EXOC8_HUMAN	exocyst complex 84-kDa subunit	318	Poly-Glu.				exocytosis|protein transport	growth cone|nucleus	protein binding			skin(1)	1	Breast(184;0.0871)	all_cancers(173;0.151)|Prostate(94;0.183)				GCTGGTTCTTCTTCTTCGTCA	0.557		NaN											0	0	0	0.01441	0	49	68									
LYST	1130	broad.mit.edu	37	1	235952011	235952011	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:235952011G>C	uc001hxj.2	-	13	4853	c.4678C>G	c.(4678-4680)CTT>GTT	p.L1560V	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	1560					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			CGAAAGATAAGAGTGGCATTG	0.358		NaN							Chediak-Higashi_syndrome				0	0	0	0.00499	0	11	46									
FMN2	56776	broad.mit.edu	37	1	240286571	240286571	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:240286571C>T	uc010pyd.1	+	2	1933	c.1708C>T	c.(1708-1710)CTT>TTT	p.L570F	FMN2_uc010pye.1_Missense_Mutation_p.L570F	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	570					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TGCCATGGGTCTTCTCCTTCC	0.502		NaN											0	0	0	0.012319	0	19	81									
OR2T4	127074	broad.mit.edu	37	1	248525601	248525601	+	Missense_Mutation	SNP	T	T	C			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:248525601T>C	uc001ieh.1	+	1	719	c.719T>C	c.(718-720)CTC>CCC	p.L240P		NM_001004696	NP_001004696	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T,	240	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTCATGCTCCTCATCCCTGTG	0.483		NaN											0	0	0	0.006122	0	14	203									
GTPBP4	23560	broad.mit.edu	37	10	1042070	1042070	+	Silent	SNP	G	G	C			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr10:1042070G>C	uc001ift.2	+	4	419	c.348G>C	c.(346-348)CTG>CTC	p.L116L	GTPBP4_uc010qac.1_5'UTR|GTPBP4_uc001ifu.2_RNA|GTPBP4_uc010qad.1_5'UTR|GTPBP4_uc010qae.1_Silent_p.L69L	NM_012341	NP_036473	Q9BZE4	NOG1_HUMAN	G protein-binding protein CRFG	116					negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of collagen binding|negative regulation of DNA replication|negative regulation of protein ubiquitination|protein stabilization|regulation of cyclin-dependent protein kinase activity|ribosome biogenesis	nucleolus|perinuclear region of cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)|skin(1)	2		all_epithelial(10;0.107)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.0814)	Epithelial(11;0.0513)|all cancers(11;0.135)|OV - Ovarian serous cystadenocarcinoma(14;0.173)		ATGTGCGACTGATGAAGTATG	0.413		NaN											0	0	0	0.004672	0	3	12									
TET1	80312	broad.mit.edu	37	10	70404903	70404903	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr10:70404903C>T	uc001jok.3	+	4	2922	c.2417C>T	c.(2416-2418)TCT>TTT	p.S806F		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	806					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						GCTATGAGCTCTGTTGCTACT	0.358		NaN											0	0	0	0.003755	0	29	79									
KCNMA1	3778	broad.mit.edu	37	10	78669798	78669798	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr10:78669798C>G	uc001jxn.2	-	25	3250	c.3073G>C	c.(3073-3075)GAA>CAA	p.E1025Q	KCNMA1_uc001jxj.2_Missense_Mutation_p.E971Q|KCNMA1_uc001jxk.1_Missense_Mutation_p.E643Q|KCNMA1_uc009xrt.1_Missense_Mutation_p.E816Q|KCNMA1_uc001jxl.1_Missense_Mutation_p.E650Q|KCNMA1_uc001jxo.2_Missense_Mutation_p.E1008Q|KCNMA1_uc001jxm.2_Missense_Mutation_p.E967Q|KCNMA1_uc001jxq.2_Missense_Mutation_p.E997Q	NM_001161352	NP_001154824	Q12791	KCMA1_HUMAN	large conductance calcium-activated potassium	1025	Calcium bowl.|Cytoplasmic (Potential).				cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	AGGTACAGTTCTGTATCAGGG	0.473		NaN											0	0	0	0.003271	0	29	17									
DLG5	9231	broad.mit.edu	37	10	79565534	79565534	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr10:79565534G>A	uc001jzk.2	-	27	5123	c.5053C>T	c.(5053-5055)CGC>TGC	p.R1685C	DLG5_uc001jzi.2_Missense_Mutation_p.R440C|DLG5_uc001jzj.2_Missense_Mutation_p.R1100C|DLG5_uc009xru.1_RNA	NM_004747	NP_004738	Q8TDM6	DLG5_HUMAN	discs large homolog 5	1685					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			ovary(5)|breast(3)	8	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			AAGGACCGGCGTGCAGCCGCT	0.552		NaN											0	0	0	0.01441	0	83	37									
OR52E8	390079	broad.mit.edu	37	11	5878060	5878060	+	Silent	SNP	G	G	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr11:5878060G>T	uc010qzr.1	-	1	873	c.873C>A	c.(871-873)GCC>GCA	p.A291A	TRIM5_uc001mbq.1_Intron	NM_001005168	NP_001005168	Q6IFG1	O52E8_HUMAN	olfactory receptor, family 52, subfamily E,	291	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.114)		Epithelial(150;2.37e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAGGATTGAGGGCTGGTGGGA	0.423		NaN											1	0	2.02624e-56	0.01441	2.25348e-56	85	145									
NLRP14	338323	broad.mit.edu	37	11	7064578	7064578	+	Missense_Mutation	SNP	G	G	A	rs147389856	byFrequency	TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr11:7064578G>A	uc001mfb.1	+	4	1644	c.1321G>A	c.(1321-1323)GTG>ATG	p.V441M		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	441	NACHT.		V -> M.		cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		TATGACTTACGTGTTTTACAG	0.438		NaN											0	0	0	0.01441	0	63	91									
NAV2	89797	broad.mit.edu	37	11	19735319	19735319	+	Silent	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr11:19735319C>T	uc010rdm.1	+	1	439	c.78C>T	c.(76-78)CAC>CAT	p.H26H	NAV2_uc001mpp.2_Intron|NAV2_uc001mpr.3_Silent_p.H26H|LOC100126784_uc010rdl.1_3'UTR	NM_145117	NP_660093	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 2	26						nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						CCATCCTGCACGTgcccccgg	0.537		NaN											0	0	0	0.003954	0	20	16									
ZFP91	80829	broad.mit.edu	37	11	58379117	58379117	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr11:58379117G>C	uc001nmx.3	+	6	931	c.763G>C	c.(763-765)GAA>CAA	p.E255Q	ZFP91_uc001nmy.3_Missense_Mutation_p.E254Q|ZFP91-CNTF_uc010rkm.1_RNA	NM_053023	NP_444251	Q96JP5	ZFP91_HUMAN	zinc finger protein 91	255	Glu-rich.				activation of NF-kappaB-inducing kinase activity|protein K63-linked ubiquitination	nucleus	nucleic acid binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				gaaggtaaaagaagagaagga	0.209		NaN											0	0	0	0.003163	0	15	18									
STX3	6809	broad.mit.edu	37	11	59540702	59540702	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr11:59540702G>A	uc001nog.2	+	2	239	c.49G>A	c.(49-51)GAT>AAT	p.D17N	STX3_uc010rkx.1_Missense_Mutation_p.D17N|STX3_uc010rky.1_5'UTR	NM_004177	NP_004168	Q13277	STX3_HUMAN	syntaxin 3	17	Cytoplasmic (Potential).				cellular response to oxidative stress|intracellular protein transport|neuron projection development|neurotransmitter transport	apical plasma membrane|azurophil granule|cell-cell junction|growth cone|integral to membrane|plasma membrane enriched fraction|SNARE complex|specific granule	arachidonic acid binding|SNAP receptor activity			ovary(2)	2						GACACAGGATGATGATACTGA	0.348		NaN											0	0	0	0.01441	0	72	168									
STX3	6809	broad.mit.edu	37	11	59540705	59540705	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr11:59540705G>A	uc001nog.2	+	2	242	c.52G>A	c.(52-54)GAT>AAT	p.D18N	STX3_uc010rkx.1_Missense_Mutation_p.D18N|STX3_uc010rky.1_5'UTR	NM_004177	NP_004168	Q13277	STX3_HUMAN	syntaxin 3	18	Cytoplasmic (Potential).				cellular response to oxidative stress|intracellular protein transport|neuron projection development|neurotransmitter transport	apical plasma membrane|azurophil granule|cell-cell junction|growth cone|integral to membrane|plasma membrane enriched fraction|SNARE complex|specific granule	arachidonic acid binding|SNAP receptor activity			ovary(2)	2						ACAGGATGATGATACTGATGC	0.348		NaN											0	0	0	0.01441	0	73	171									
RCE1	9986	broad.mit.edu	37	11	66611253	66611253	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr11:66611253G>A	uc001ojk.1	+	2	253	c.209G>A	c.(208-210)CGA>CAA	p.R70Q	RCE1_uc001ojl.1_5'UTR	NM_005133	NP_005124	Q9Y256	FACE2_HUMAN	prenyl protein peptidase RCE1 isoform 1	70					proteolysis	endoplasmic reticulum membrane|integral to plasma membrane	metalloendopeptidase activity			ovary(1)|breast(1)	2						GTCATCAAGCGACGCTTCACC	0.672		NaN											0	0	0	0.008871	0	18	40									
GRM5	2915	broad.mit.edu	37	11	88323888	88323888	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr11:88323888C>T	uc001pcq.2	-	6	1771	c.1571G>A	c.(1570-1572)CGA>CAA	p.R524Q	GRM5_uc009yvm.2_Missense_Mutation_p.R524Q	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	524	Extracellular (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	TTCTCCCTTTCGGATCACCTA	0.378		NaN											0	0	0	0.003271	0	28	69									
EXPH5	23086	broad.mit.edu	37	11	108381102	108381102	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr11:108381102G>A	uc001pkk.2	-	6	5243	c.5132C>T	c.(5131-5133)TCA>TTA	p.S1711L	EXPH5_uc010rvy.1_Missense_Mutation_p.S1523L|EXPH5_uc010rvz.1_Missense_Mutation_p.S1555L|EXPH5_uc010rwa.1_Missense_Mutation_p.S1635L	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	1711					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		CTCATGCTTTGATGGTGATTC	0.443		NaN											0	0	0	0.004878	0	38	94									
CACNA1C	775	broad.mit.edu	37	12	2760832	2760832	+	Silent	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr12:2760832C>T	uc009zdu.1	+	34	4429	c.4116C>T	c.(4114-4116)TCC>TCT	p.S1372S	CACNA1C_uc009zdv.1_Silent_p.S1321S|CACNA1C_uc001qkb.2_Silent_p.S1324S|CACNA1C_uc001qkc.2_Silent_p.S1324S|CACNA1C_uc001qke.2_Silent_p.S1313S|CACNA1C_uc001qkf.2_Silent_p.S1313S|CACNA1C_uc001qjz.2_Silent_p.S1324S|CACNA1C_uc001qkd.2_Silent_p.S1324S|CACNA1C_uc001qkg.2_Silent_p.S1311S|CACNA1C_uc009zdw.1_Silent_p.S1346S|CACNA1C_uc001qkh.2_Silent_p.S1313S|CACNA1C_uc001qkl.2_Silent_p.S1372S|CACNA1C_uc001qkn.2_Silent_p.S1324S|CACNA1C_uc001qko.2_Silent_p.S1344S|CACNA1C_uc001qkp.2_Silent_p.S1324S|CACNA1C_uc001qkr.2_Silent_p.S1341S|CACNA1C_uc001qku.2_Silent_p.S1324S|CACNA1C_uc001qkq.2_Silent_p.S1352S|CACNA1C_uc001qks.2_Silent_p.S1324S|CACNA1C_uc001qkt.2_Silent_p.S1324S|CACNA1C_uc001qki.1_Silent_p.S1060S|CACNA1C_uc001qkj.1_Silent_p.S1060S|CACNA1C_uc001qkk.1_Silent_p.S1060S|CACNA1C_uc001qkm.1_Silent_p.S1049S|CACNA1C_uc010sea.1_Silent_p.S15S	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	1372	Extracellular (Potential).|IV.				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CCCGCATCTCCATCACCTTCT	0.612		NaN											0	0	0	0.013726	0	28	136									
ACSM4	341392	broad.mit.edu	37	12	7459281	7459281	+	Silent	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr12:7459281C>T	uc001qsx.1	+	2	354	c.354C>T	c.(352-354)GCC>GCT	p.A118A		NM_001080454	NP_001073923	P0C7M7	ACSM4_HUMAN	acyl-CoA synthetase medium-chain family member 4	118					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding				0						ACCGTTTGGCCGTGATTCTGC	0.512		NaN											0	0	0	0.012213	0	25	11									
CLEC4E	26253	broad.mit.edu	37	12	8691854	8691854	+	Missense_Mutation	SNP	G	G	A	rs137962363		TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr12:8691854G>A	uc001quo.1	-	3	344	c.179C>T	c.(178-180)CCT>CTT	p.P60L		NM_014358	NP_055173	Q9ULY5	CLC4E_HUMAN	C-type lectin domain family 4, member E	60	Extracellular (Potential).					integral to membrane	sugar binding			central_nervous_system(1)	1	Lung SC(5;0.184)					GAAATTCTCAGGTAGCTGAAA	0.358		NaN											0	0	0	0.008291	0	10	230									
PLCZ1	89869	broad.mit.edu	37	12	18854476	18854476	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr12:18854476C>T	uc010sid.1	-	9	1167	c.976G>A	c.(976-978)GTA>ATA	p.V326I	PLCZ1_uc001rdv.3_Missense_Mutation_p.V222I|PLCZ1_uc001rdw.3_Missense_Mutation_p.V67I|PLCZ1_uc001rdu.1_Missense_Mutation_p.V108I|PLCZ1_uc009zil.1_RNA	NM_033123	NP_149114	Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	326					intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					AACTTTTTTACCCCTGTTTCC	0.264		NaN											0	0	0	0.01441	0	46	32									
PRKAG1	5571	broad.mit.edu	37	12	49406886	49406886	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr12:49406886G>C	uc001rsy.2	-	2	86	c.17C>G	c.(16-18)TCT>TGT	p.S6C	uc001rsw.2_Intron|PRKAG1_uc010smd.1_5'UTR|PRKAG1_uc001rsx.2_5'UTR|PRKAG1_uc001rsz.2_Missense_Mutation_p.S6C|PRKAG1_uc009zlb.2_5'UTR|PRKAG1_uc010sme.1_Missense_Mutation_p.S6C	NM_002733	NP_002724	P54619	AAKG1_HUMAN	AMP-activated protein kinase, noncatalytic	6					cell cycle arrest|fatty acid biosynthetic process|insulin receptor signaling pathway|positive regulation of protein kinase activity|regulation of fatty acid oxidation|regulation of glycolysis|spermatogenesis	cytosol	cAMP-dependent protein kinase activity|cAMP-dependent protein kinase regulator activity|protein kinase binding			kidney(1)	1						GCTATCTGAAGAAATGACCTG	0.423		NaN											0	0	0	0.009718	0	38	23									
MLL2	8085	broad.mit.edu	37	12	49443634	49443634	+	Missense_Mutation	SNP	G	G	A	rs112921115		TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr12:49443634G>A	uc001rta.3	-	11	3737	c.3737C>T	c.(3736-3738)ACG>ATG	p.T1246M		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1246					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						ACTAACATCCGTAGAGACCCC	0.602		NaN	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.01441	0	97	80									
MLL2	8085	broad.mit.edu	37	12	49446856	49446856	+	Splice_Site	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr12:49446856C>T	uc001rta.3	-	8	955	c.955_splice	c.e8-1	p.A319_splice		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2						chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CCCGGCACGCCTAAGGGAAGG	0.532		NaN	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.01441	0	47	111									
KRT18	3875	broad.mit.edu	37	12	53343177	53343177	+	Missense_Mutation	SNP	A	A	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr12:53343177A>T	uc001sbe.2	+	2	289	c.220A>T	c.(220-222)ATG>TTG	p.M74L	KRT18_uc009zmn.1_Missense_Mutation_p.M74L|KRT18_uc001sbf.1_5'UTR|KRT18_uc001sbg.2_Missense_Mutation_p.M74L|KRT18_uc009zmo.2_Missense_Mutation_p.M74L|KRT8_uc009zml.1_Intron|KRT8_uc009zmm.1_Intron	NM_199187	NP_954657	P05783	K1C18_HUMAN	keratin 18	74	Head.|Necessary for interaction with PNN.				anatomical structure morphogenesis|cell cycle|Golgi to plasma membrane CFTR protein transport|interspecies interaction between organisms|negative regulation of apoptosis	centriolar satellite|keratin filament|perinuclear region of cytoplasm	protein binding|structural molecule activity			skin(1)	1						TCTGGCAGGAATGGGAGGCAT	0.662		NaN											0	0	0	0.012213	0	30	55									
OR6C74	254783	broad.mit.edu	37	12	55641322	55641322	+	Missense_Mutation	SNP	C	C	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr12:55641322C>A	uc010spg.1	+	1	251	c.251C>A	c.(250-252)GCA>GAA	p.A84E		NM_001005490	NP_001005490	A6NCV1	O6C74_HUMAN	olfactory receptor, family 6, subfamily C,	84	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						GTTAGTATGGCAACAGGTGAT	0.398		NaN											1	0	1.61879e-10	0.013537	1.6751e-10	10	266									
NUDT4	11163	broad.mit.edu	37	12	93793095	93793095	+	Missense_Mutation	SNP	T	T	G			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr12:93793095T>G	uc001tcm.2	+	5	881	c.483T>G	c.(481-483)GAT>GAG	p.D161E	NUDT4_uc010sup.1_Missense_Mutation_p.D161E|NUDT4_uc001tcn.2_Missense_Mutation_p.D109E|NUDT4_uc010suq.1_Missense_Mutation_p.D110E|NUDT4_uc001tco.2_Missense_Mutation_p.D109E	NM_019094	NP_061967	Q9NZJ9	NUDT4_HUMAN	nudix-type motif 4 isoform alpha	161					calcium-mediated signaling|cyclic nucleotide metabolic process|cyclic-nucleotide-mediated signaling|intracellular transport|regulation of RNA export from nucleus	cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding				0						CCCTTCCGGATAATAATGCCT	0.478		NaN											0	0	0	0.008291	0	8	283									
GOLGA2B	55592	broad.mit.edu	37	12	100551433	100551433	+	Missense_Mutation	SNP	C	C	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr12:100551433C>A	uc001tgs.2	-	4	607	c.163G>T	c.(163-165)GCC>TCC	p.A55S	GOLGA2B_uc001tgt.2_RNA|GOLGA2B_uc001tgu.2_Missense_Mutation_p.A55S|uc001tgx.2_5'Flank	NM_017600	NP_060070			golgi autoantigen, golgin subfamily a, 2-like 1												0						ATGAGCCAGGCGCTGGCAGTG	0.622		NaN											1	0	3.73148e-12	0.007291	3.87813e-12	22	47									
EID3	493861	broad.mit.edu	37	12	104697751	104697751	+	Silent	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr12:104697751C>T	uc001tkw.2	+	1	203	c.39C>T	c.(37-39)TCC>TCT	p.S13S	TXNRD1_uc010swk.1_Intron|TXNRD1_uc010swl.1_Intron|TXNRD1_uc010swm.1_Intron|TXNRD1_uc010swn.1_Intron|TXNRD1_uc010swo.1_Intron|TXNRD1_uc010swp.1_Intron|TXNRD1_uc010swq.1_Intron|TXNRD1_uc001tku.2_Intron|TXNRD1_uc001tko.1_Intron|TXNRD1_uc001tkp.1_Intron|TXNRD1_uc001tkv.1_Intron	NM_001008394	NP_001008395	Q8N140	EID3_HUMAN	EP300 interacting inhibitor of differentiation	13					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus					0						CGGGCTGCTCCGACGACCTCA	0.662		NaN											0	0	0	0.000602	0	5	22									
POLR3B	55703	broad.mit.edu	37	12	106890641	106890641	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr12:106890641G>A	uc001tlp.2	+	25	3151	c.2929G>A	c.(2929-2931)GTT>ATT	p.V977I	POLR3B_uc001tlq.2_Missense_Mutation_p.V919I	NM_018082	NP_060552	Q9NW08	RPC2_HUMAN	DNA-directed RNA polymerase III B isoform 1	977					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			ovary(1)|central_nervous_system(1)	2						TGAGGACCTCGTTCGCCATGG	0.488		NaN											0	0	0	0.01441	0	42	102									
GLTP	51228	broad.mit.edu	37	12	110318126	110318126	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr12:110318126G>C	uc001tpm.2	-	1	168	c.54C>G	c.(52-54)ATC>ATG	p.I18M	GLTP_uc010sxt.1_RNA	NM_016433	NP_057517	Q9NZD2	GLTP_HUMAN	glycolipid transfer protein	18						cytoplasm	glycolipid binding|glycolipid transporter activity				0		Lung NSC(355;2.38e-06)|Breast(359;0.00354)|Myeloproliferative disorder(1001;0.0122)		BRCA - Breast invasive adenocarcinoma(302;0.0025)		GCCCGGTCTCGATCTGCTTGT	0.627		NaN											0	0	0	0.00499	0	12	24									
GIT2	9815	broad.mit.edu	37	12	110397701	110397701	+	Silent	SNP	G	G	C			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr12:110397701G>C	uc001tps.2	-	12	1215	c.1050C>G	c.(1048-1050)CTC>CTG	p.L350L	GIT2_uc001tpq.2_Silent_p.L350L|GIT2_uc001tpv.2_Silent_p.L352L|GIT2_uc001tpu.2_Silent_p.L350L|GIT2_uc001tpt.2_Silent_p.L350L|GIT2_uc010sxu.1_Silent_p.L288L|GIT2_uc001tpw.2_Silent_p.L350L|GIT2_uc010sxv.1_Silent_p.L350L	NM_057169	NP_476510	Q14161	GIT2_HUMAN	G protein-coupled receptor kinase interacting	350					regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	nucleoplasm	ARF GTPase activator activity|protein binding|zinc ion binding			central_nervous_system(1)	1						TGGCGTCACTGAGAATGTCAA	0.463		NaN											0	0	0	0.005443	0	22	59									
C12orf51	283450	broad.mit.edu	37	12	112696955	112696955	+	Silent	SNP	C	C	G			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr12:112696955C>G	uc009zwc.2	-	12	1710	c.1692G>C	c.(1690-1692)CTG>CTC	p.L564L	C12orf51_uc010syk.1_Silent_p.L387L|C12orf51_uc001tts.2_Silent_p.L387L|C12orf51_uc001ttt.3_Silent_p.L385L	NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						GCTGAGGCATCAGGGCATCCG	0.483		NaN											0	0	0	0.01441	0	41	694									
SFRS9	8683	broad.mit.edu	37	12	120901878	120901878	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr12:120901878C>T	uc001tyi.2	-	3	543	c.397G>A	c.(397-399)GAA>AAA	p.E133K		NM_003769	NP_003760	Q13242	SRSF9_HUMAN	splicing factor, arginine/serine-rich 9	133	RRM 2.				mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|RNA binding				0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TCCCCAGCTTCTCGCATGTGA	0.507		NaN											0	0	0	0.01441	0	45	149									
VPS33A	65082	broad.mit.edu	37	12	122723263	122723263	+	Silent	SNP	A	A	G			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr12:122723263A>G	uc001ucd.2	-	10	1286	c.1173T>C	c.(1171-1173)AAT>AAC	p.N391N	VPS33A_uc001ucc.2_RNA	NM_022916	NP_075067	Q96AX1	VP33A_HUMAN	vacuolar protein sorting 33A	391					lysosome localization|melanosome localization|platelet formation|protein transport|regulation of developmental pigmentation|vesicle docking involved in exocytosis	early endosome|late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			skin(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000336)|Epithelial(86;0.000606)|BRCA - Breast invasive adenocarcinoma(302;0.23)		CCTCAATGTAATTGTTGACCT	0.259		NaN											0	0	0	0.01441	0	53	114									
RIMBP2	23504	broad.mit.edu	37	12	130926783	130926783	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr12:130926783C>T	uc001uil.2	-	8	1227	c.1063G>A	c.(1063-1065)GAG>AAG	p.E355K	RIMBP2_uc001uim.2_Missense_Mutation_p.E263K|RIMBP2_uc001uin.1_Missense_Mutation_p.E14K	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	355	Fibronectin type-III 1.					cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		TTGAGCTTCTCGATGAGGGCT	0.612		NaN											0	0	0	0.006122	0	14	72									
OR4K2	390431	broad.mit.edu	37	14	20345191	20345191	+	Silent	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr14:20345191C>T	uc001vwh.1	+	1	765	c.765C>T	c.(763-765)ATC>ATT	p.I255I		NM_001005501	NP_001005501	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K,	255	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GGCCATGCATCTTCATCTACA	0.408		NaN											0	0	0	0.00278	0	21	92									
PROX2	283571	broad.mit.edu	37	14	75330507	75330507	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr14:75330507G>A	uc001xqr.1	-	1	31	c.31C>T	c.(31-33)CAG>TAG	p.Q11*	PROX2_uc001xqq.1_5'UTR	NM_001080408	NP_001073877	Q3B8N5	PROX2_HUMAN	prospero homeobox 2	11					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00652)		ATCTGGGGCTGAGGAGAAAGC	0.542		NaN											0	0	0	0.007291	0	22	69									
C14orf179	112752	broad.mit.edu	37	14	76548711	76548711	+	Splice_Site	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr14:76548711G>A	uc010asm.1	+	6	402	c.368_splice	c.e6+1	p.S123_splice	C14orf179_uc001xsf.2_RNA|C14orf179_uc010asl.1_Silent_p.R123R|C14orf179_uc001xsg.2_Splice_Site_p.S128_splice|C14orf179_uc010tve.1_Splice_Site	NM_001102564	NP_001096034	Q96FT9	IFT43_HUMAN	hypothetical protein LOC112752 isoform 2						cilium morphogenesis|intraflagellar retrograde transport						0				BRCA - Breast invasive adenocarcinoma(234;0.0199)		CCCCTCCCAGGTAGGTTAAAT	0.453		NaN											0	0	0	0.01441	0	84	217									
DICER1	23405	broad.mit.edu	37	14	95590756	95590756	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr14:95590756G>A	uc001ydw.2	-	9	1335	c.1153C>T	c.(1153-1155)CGC>TGC	p.R385C	DICER1_uc001ydv.2_Missense_Mutation_p.R375C|DICER1_uc001ydx.2_Missense_Mutation_p.R385C	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	385	Required for interaction with PRKRA and TARBP2.				negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		TTATATTTGCGTAAGATTTCG	0.378		NaN	Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				0	0	0	0.00874	0	39	56									
AQR	9716	broad.mit.edu	37	15	35202345	35202345	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr15:35202345C>T	uc001ziv.2	-	17	1835	c.1654G>A	c.(1654-1656)GAA>AAA	p.E552K		NM_014691	NP_055506	O60306	AQR_HUMAN	aquarius	552						catalytic step 2 spliceosome	RNA binding			large_intestine(1)	1		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)		CCTTCCCATTCATCTTTGATG	0.368		NaN											0	0	0	0.01441	0	45	104									
KIAA0101	9768	broad.mit.edu	37	15	64669028	64669028	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr15:64669028G>C	uc002ank.2	-	3	336	c.204C>G	c.(202-204)TTC>TTG	p.F68L	KIAA0101_uc002anl.2_Intron	NM_014736	NP_055551	Q15004	PAF_HUMAN	hypothetical protein LOC9768 isoform 1	68				F->A: Loss of binding to PCNA.		mitochondrion|nucleus				central_nervous_system(1)	1						ACAACCTAAAGAATTCTCCAA	0.403		NaN											0	0	0	0.013726	0	32	21									
STARD5	80765	broad.mit.edu	37	15	81605711	81605711	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr15:81605711G>T	uc002bgm.2	-	6	612	c.528C>A	c.(526-528)TTC>TTA	p.F176L	STARD5_uc002bgn.2_Missense_Mutation_p.F69L	NM_181900	NP_871629	Q9NSY2	STAR5_HUMAN	StAR-related lipid transfer protein 5	176	START.				C21-steroid hormone biosynthetic process|lipid transport	cytosol	lipid binding			ovary(1)	1						GGTCGGTATGGAAGAATGTGA	0.567		NaN											1	0	1.67211e-32	0.01441	1.84242e-32	42	96									
AEN	64782	broad.mit.edu	37	15	89169733	89169733	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr15:89169733C>T	uc002bmt.2	+	2	444	c.293C>T	c.(292-294)GCT>GTT	p.A98V	AEN_uc010bnl.2_Missense_Mutation_p.A98V|AEN_uc010bnm.1_Missense_Mutation_p.A98V	NM_022767	NP_073604	Q8WTP8	AEN_HUMAN	interferon stimulated exonuclease gene	98					apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|response to ionizing radiation	nucleolus|nucleoplasm	exonuclease activity|nucleic acid binding				0						AGAAGGCCTGCTCCCGGGAAA	0.662		NaN											0	0	0	0.006122	0	16	47									
NOXO1	124056	broad.mit.edu	37	16	2029284	2029284	+	Silent	SNP	C	C	G			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr16:2029284C>G	uc002cnx.2	-	8	904	c.900G>C	c.(898-900)CTG>CTC	p.L300L	NOXO1_uc002cnz.2_Silent_p.L294L|NOXO1_uc002coa.2_Silent_p.L299L|NOXO1_uc002cny.2_Silent_p.L295L	NM_172168	NP_751908	Q8NFA2	NOXO1_HUMAN	NADPH oxidase organizer 1 isoform c	300					cell communication|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst	NADPH oxidase complex	enzyme binding|phosphatidylinositol binding|superoxide-generating NADPH oxidase activator activity				0						CCGTCCCGCTCAGGAGAGCGC	0.776		NaN											0	0	0	0.000602	0	3	2									
NOXO1	124056	broad.mit.edu	37	16	2029448	2029448	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr16:2029448C>G	uc002cnx.2	-	7	815	c.811G>C	c.(811-813)GAC>CAC	p.D271H	NOXO1_uc002cnz.2_Missense_Mutation_p.D265H|NOXO1_uc002coa.2_Missense_Mutation_p.D270H|NOXO1_uc002cny.2_Missense_Mutation_p.D266H	NM_172168	NP_751908	Q8NFA2	NOXO1_HUMAN	NADPH oxidase organizer 1 isoform c	271	SH3 2.				cell communication|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst	NADPH oxidase complex	enzyme binding|phosphatidylinositol binding|superoxide-generating NADPH oxidase activator activity				0						CAGCCGCGGTCTGACGTTTCC	0.721		NaN											0	0	0	0.004672	0	3	14									
ZNF19	7567	broad.mit.edu	37	16	71509173	71509173	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr16:71509173G>T	uc010cgc.1	-	6	1783	c.1277C>A	c.(1276-1278)TCC>TAC	p.S426Y	ZNF23_uc002fai.2_Intron|ZNF19_uc002fak.1_Missense_Mutation_p.S414Y|ZNF19_uc002fal.1_Missense_Mutation_p.S414Y|ZNF19_uc002fam.1_Missense_Mutation_p.S426Y	NM_006961	NP_008892	P17023	ZNF19_HUMAN	zinc finger protein 19	426	C2H2-type 10; atypical.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Ovarian(137;0.00965)		BRCA - Breast invasive adenocarcinoma(221;0.0161)|Kidney(780;0.0598)		ACCTAGCTGGGAAGAAGTCCC	0.328		NaN											1	0	0.00448238	0.004482	0.00457857	9	31									
DHX38	9785	broad.mit.edu	37	16	72138398	72138398	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr16:72138398G>A	uc002fcb.2	+	15	2379	c.2024G>A	c.(2023-2025)CGC>CAC	p.R675H	DHX38_uc010vmp.1_Intron	NM_014003	NP_054722	Q92620	PRP16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 38	675	Helicase ATP-binding.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1		Ovarian(137;0.125)				GTGGCTCGGCGCTCAGACCTG	0.612		NaN											0	0	0	0.008291	0	8	28									
PLCG2	5336	broad.mit.edu	37	16	81914556	81914556	+	Silent	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr16:81914556G>A	uc002fgt.2	+	8	842	c.690G>A	c.(688-690)CTG>CTA	p.L230L	PLCG2_uc010chg.1_Silent_p.L230L	NM_002661	NP_002652	P16885	PLCG2_HUMAN	phospholipase C, gamma 2	230					intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			large_intestine(4)|lung(2)|ovary(1)|skin(1)	8						TGTTCATCCTGGGGTGAGGCA	0.537		NaN											0	0	0	0.01441	0	68	102									
SMTNL2	342527	broad.mit.edu	37	17	4497118	4497118	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr17:4497118G>C	uc002fyf.1	+	4	799	c.732G>C	c.(730-732)GAG>GAC	p.E244D	SMTNL2_uc002fye.2_Missense_Mutation_p.E100D	NM_001114974	NP_001108446	Q2TAL5	SMTL2_HUMAN	smoothelin-like 2 isoform 1	244											0				READ - Rectum adenocarcinoma(115;0.0325)		CTTCCACAGAGAAGAATTCCT	0.577		NaN											0	0	0	0.013537	0	10	71									
SLC47A1	55244	broad.mit.edu	37	17	19451306	19451306	+	Silent	SNP	G	G	C			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr17:19451306G>C	uc002gvy.1	+	4	401	c.315G>C	c.(313-315)GGG>GGC	p.G105G	SLC47A1_uc010vyy.1_RNA|SLC47A1_uc002gvx.2_Silent_p.G105G|SLC47A1_uc010vyz.1_Silent_p.G82G|SLC47A1_uc010cqp.1_Silent_p.G105G|SLC47A1_uc010cqq.1_5'UTR	NM_018242	NP_060712	Q96FL8	S47A1_HUMAN	solute carrier family 47, member 1	105	Cytoplasmic (Potential).					integral to membrane|plasma membrane	drug:hydrogen antiporter activity				0	all_cancers(12;2.49e-05)|all_epithelial(12;0.00263)|Hepatocellular(7;0.00345)					AGACGTACGGGAGCCAGAACC	0.592		NaN											0	0	0	0.00278	0	23	37									
LGALS9	3965	broad.mit.edu	37	17	25967775	25967775	+	Silent	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr17:25967775C>T	uc002gzp.2	+	3	427	c.309C>T	c.(307-309)TTC>TTT	p.F103F	LGALS9_uc002gzq.2_Silent_p.F103F|LGALS9_uc002gzr.2_Silent_p.F46F|LGALS9_uc010waa.1_Silent_p.F46F|LGALS9_uc002gzs.2_Silent_p.F103F	NM_009587	NP_033665	O00182	LEG9_HUMAN	galectin-9 isoform long	103	Galectin 1.				positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|extracellular region	galactose binding|signal transducer activity				0	Lung NSC(42;0.0103)		BRCA - Breast invasive adenocarcinoma(3;0.0141)	UCEC - Uterine corpus endometrioid carcinoma (53;0.155)		ACCTCTGCTTCCTGGTGCAGA	0.572		NaN											0	0	0	0.009535	0	30	57									
PHF12	57649	broad.mit.edu	37	17	27237353	27237353	+	Silent	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr17:27237353G>A	uc002hdg.1	-	11	2780	c.2250C>T	c.(2248-2250)ATC>ATT	p.I750I	PHF12_uc010wbb.1_Silent_p.I732I|PHF12_uc002hdi.1_Silent_p.I746I|PHF12_uc002hdh.1_Silent_p.I533I	NM_001033561	NP_001028733	Q96QT6	PHF12_HUMAN	PHD finger protein 12 isoform 1	750					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	protein binding|zinc ion binding			ovary(1)	1	all_cancers(5;1.95e-14)|all_epithelial(6;5e-18)|Lung NSC(42;0.01)		Epithelial(11;1.64e-05)|all cancers(11;7.47e-05)|BRCA - Breast invasive adenocarcinoma(11;9.79e-05)			CCAGAAACTTGATCAGCTTCT	0.493		NaN											0	0	0	0.01441	0	103	5									
PHF12	57649	broad.mit.edu	37	17	27254016	27254016	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr17:27254016C>T	uc002hdg.1	-	3	844	c.314G>A	c.(313-315)CGC>CAC	p.R105H	PHF12_uc010wbb.1_Missense_Mutation_p.R87H|PHF12_uc002hdi.1_Missense_Mutation_p.R101H|PHF12_uc002hdj.1_Missense_Mutation_p.R105H|PHF12_uc010crw.1_5'UTR|PHF12_uc002hdk.1_Missense_Mutation_p.R101H|uc002hdl.2_Intron|PHF12_uc002hdh.1_5'Flank	NM_001033561	NP_001028733	Q96QT6	PHF12_HUMAN	PHD finger protein 12 isoform 1	105	PHD-type 1.|Interaction with SIN3A.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	protein binding|zinc ion binding			ovary(1)	1	all_cancers(5;1.95e-14)|all_epithelial(6;5e-18)|Lung NSC(42;0.01)		Epithelial(11;1.64e-05)|all cancers(11;7.47e-05)|BRCA - Breast invasive adenocarcinoma(11;9.79e-05)			TACCTTTCGGCGAACAGTGCA	0.493		NaN											0	0	0	0.005443	0	23	125									
CPD	1362	broad.mit.edu	37	17	28776730	28776730	+	Silent	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr17:28776730C>T	uc002hfb.1	+	13	3048	c.3033C>T	c.(3031-3033)CTC>CTT	p.L1011L	CPD_uc010wbo.1_Silent_p.L764L|CPD_uc010wbp.1_Intron	NM_001304	NP_001295	O75976	CBPD_HUMAN	carboxypeptidase D precursor	1011	Extracellular (Potential).|Carboxypeptidase-like 3.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			liver(1)|skin(1)	2						CAGAATTTCTCTGCCTGAACT	0.428		NaN											0	0	0	0.01441	0	124	93									
ACACA	31	broad.mit.edu	37	17	35506883	35506883	+	Missense_Mutation	SNP	T	T	C			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr17:35506883T>C	uc002hnm.2	-	45	5664	c.5473A>G	c.(5473-5475)ATT>GTT	p.I1825V	ACACA_uc002hnk.2_Missense_Mutation_p.I1747V|ACACA_uc002hnl.2_Missense_Mutation_p.I1767V|ACACA_uc002hnn.2_Missense_Mutation_p.I1825V|ACACA_uc002hno.2_Missense_Mutation_p.I1862V|ACACA_uc010cuy.2_Missense_Mutation_p.I470V|ACACA_uc010wdc.1_5'UTR	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	1825	Carboxyltransferase.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	CCAATCCCAATGGCCCGGCAC	0.428		NaN											0	0	0	0.003954	0	26	62									
KRT35	3886	broad.mit.edu	37	17	39635732	39635732	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr17:39635732C>G	uc002hws.2	-	3	621	c.578G>C	c.(577-579)CGG>CCG	p.R193P		NM_002280	NP_002271	Q92764	KRT35_HUMAN	keratin 35	193	Rod.|Coil 1B.				anatomical structure morphogenesis	intermediate filament	protein binding|structural molecule activity			ovary(1)|skin(1)	2		Breast(137;0.000286)				CACCAGCTGCCGCAGGGACAC	0.587		NaN											0	0	0	0.01441	0	79	76									
KIAA1267	284058	broad.mit.edu	37	17	44144914	44144914	+	Splice_Site	SNP	C	C	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr17:44144914C>A	uc002ikb.2	-	4	1737	c.1652_splice	c.e4+1	p.T551_splice	KIAA1267_uc002ikc.2_Splice_Site_p.T551_splice|KIAA1267_uc002ikd.2_Splice_Site_p.T551_splice|KIAA1267_uc010dav.2_Splice_Site_p.T551_splice	NM_015443	NP_056258	Q7Z3B3	K1267_HUMAN	hypothetical protein LOC284058							MLL1 complex	protein binding			skin(2)	2		Melanoma(429;0.211)				CTAAAACTTACGTGTTAATAA	0.413		NaN											1	0	6.17242e-35	0.01441	6.83272e-35	43	48									
RSAD1	55316	broad.mit.edu	37	17	48561095	48561095	+	Missense_Mutation	SNP	C	C	T	rs148371199		TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr17:48561095C>T	uc002iqw.1	+	7	1137	c.1081C>T	c.(1081-1083)CGC>TGC	p.R361C	RSAD1_uc010wmq.1_Intron	NM_018346	NP_060816	Q9HA92	RSAD1_HUMAN	radical S-adenosyl methionine domain containing	361					porphyrin biosynthetic process	mitochondrion	4 iron, 4 sulfur cluster binding|coproporphyrinogen oxidase activity|metal ion binding				0	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			CCTGGGGCTACGCACCGATGT	0.537		NaN											0	0	0	0.003163	0	12	53									
MKS1	54903	broad.mit.edu	37	17	56283666	56283666	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr17:56283666C>G	uc002ivr.1	-	17	1641	c.1566G>C	c.(1564-1566)CAG>CAC	p.Q522H	MKS1_uc010wnq.1_Missense_Mutation_p.Q319H|MKS1_uc002ivs.1_Missense_Mutation_p.R450T	NM_017777	NP_060247	Q9NXB0	MKS1_HUMAN	Meckel syndrome type 1 protein isoform 1	522					cilium assembly	centrosome|cilium|microtubule basal body	protein binding			ovary(1)	1						GAATGGAACTCTGCTGGCTGA	0.562		NaN											0	0	0	0.01441	0	52	170									
TBX2	6909	broad.mit.edu	37	17	59480480	59480480	+	Missense_Mutation	SNP	A	A	G			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr17:59480480A>G	uc010wox.1	+	3	1003	c.722A>G	c.(721-723)GAC>GGC	p.D241G	TBX2_uc002ize.2_Missense_Mutation_p.D231G|TBX2_uc002izg.2_Missense_Mutation_p.D87G	NM_005994	NP_005985	Q13207	TBX2_HUMAN	T-box 2	241	T-box.				cell aging|positive regulation of cell proliferation		sequence-specific DNA binding				0						CGAGCCAACGACATCCTGAAG	0.632		NaN											0	0	0	0.003755	0	32	80									
STRADA	92335	broad.mit.edu	37	17	61787907	61787907	+	Silent	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr17:61787907G>A	uc002jbm.2	-	8	684	c.525C>T	c.(523-525)ATC>ATT	p.I175I	STRADA_uc002jbn.2_Silent_p.I117I|STRADA_uc002jbo.2_Silent_p.I138I|STRADA_uc002jbp.2_Silent_p.I138I|STRADA_uc002jbq.2_Silent_p.I117I|STRADA_uc010wpq.1_Silent_p.I131I|STRADA_uc010wpr.1_Silent_p.I146I|STRADA_uc010ddw.2_Silent_p.I146I|STRADA_uc002jbr.2_Silent_p.I117I	NM_001003787	NP_001003787	Q7RTN6	STRAA_HUMAN	STE20-related kinase adaptor alpha isoform 1	175	Protein kinase.				activation of protein kinase activity|cell cycle arrest|insulin receptor signaling pathway|protein export from nucleus|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|kinase binding|protein kinase activity			ovary(1)	1						CCCCCTGCAGGATGTAAGCAA	0.502		NaN											0	0	0	0.006122	0	15	43									
BPTF	2186	broad.mit.edu	37	17	65942274	65942274	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr17:65942274C>T	uc002jgf.2	+	21	7511	c.7450C>T	c.(7450-7452)CAC>TAC	p.H2484Y	BPTF_uc002jge.2_Intron|BPTF_uc002jgg.2_Intron|BPTF_uc002jgh.2_5'Flank	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	2610					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			TGTGCAGACTCACCAGATTCA	0.493		NaN											0	0	0	0.014323	0	19	64									
SRP68	6730	broad.mit.edu	37	17	74037019	74037019	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr17:74037019G>A	uc002jqk.1	-	14	1600	c.1565C>T	c.(1564-1566)TCA>TTA	p.S522L	SRP68_uc010wsu.1_Missense_Mutation_p.S421L|SRP68_uc002jql.1_Missense_Mutation_p.S484L|SRP68_uc002jqj.1_Missense_Mutation_p.S183L	NM_014230	NP_055045	Q9UHB9	SRP68_HUMAN	signal recognition particle 68kDa	522					response to drug	cytosol|endoplasmic reticulum|nucleolus|ribosome|signal recognition particle, endoplasmic reticulum targeting	RNA binding|signal recognition particle binding			ovary(1)	1						GCACTTCTCTGACCGCACTTG	0.582		NaN											0	0	0	0.01441	0	68	80									
MC5R	4161	broad.mit.edu	37	18	13826367	13826367	+	Silent	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr18:13826367G>A	uc010xaf.1	+	1	603	c.603G>A	c.(601-603)CTG>CTA	p.L201L		NM_005913	NP_005904	P33032	MC5R_HUMAN	melanocortin 5 receptor	201	Helical; Name=5; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			ovary(3)|lung(2)|breast(1)	6						TGTTCCTCCTGGTGTCTCTGT	0.587		NaN											0	0	0	0.01441	0	174	519									
OSBPL1A	114876	broad.mit.edu	37	18	21948276	21948276	+	Missense_Mutation	SNP	C	C	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr18:21948276C>A	uc002kve.2	-	3	356	c.182G>T	c.(181-183)AGA>ATA	p.R61I		NM_080597	NP_542164	Q9BXW6	OSBL1_HUMAN	oxysterol-binding protein-like 1A isoform B	61	ANK 1.				cholesterol metabolic process|lipid transport|vesicle-mediated transport		phospholipid binding			ovary(4)	4	all_cancers(21;0.000396)|all_epithelial(16;4.36e-06)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0505)|Ovarian(20;0.17)					GACCACTTGTCTGTGTCCAAA	0.318		NaN											1	0	2.14674e-31	0.01441	2.34369e-31	38	77									
FECH	2235	broad.mit.edu	37	18	55221549	55221549	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr18:55221549G>T	uc002lgq.3	-	9	1137	c.1020C>A	c.(1018-1020)GAC>GAA	p.D340E	FECH_uc002lgp.3_Missense_Mutation_p.D346E|FECH_uc002lgr.3_Missense_Mutation_p.D198E	NM_000140	NP_000131	P22830	HEMH_HUMAN	ferrochelatase isoform b precursor	340					generation of precursor metabolites and energy|heme biosynthetic process|protoporphyrinogen IX metabolic process|response to light stimulus	mitochondrial inner membrane|mitochondrial matrix	2 iron, 2 sulfur cluster binding|ferrochelatase activity|ferrous iron binding|protein binding			central_nervous_system(1)	1		Colorectal(73;0.227)				TTTCAATATGGTCACTGGTAA	0.453		NaN											1	0	2.61193e-14	0.009535	2.7385e-14	31	180									
MED16	10025	broad.mit.edu	37	19	886012	886012	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr19:886012C>T	uc002lqd.1	-	5	788	c.637G>A	c.(637-639)GTG>ATG	p.V213M	MED16_uc010drw.1_Missense_Mutation_p.V38M|MED16_uc002lqe.2_Missense_Mutation_p.V202M|MED16_uc002lqf.2_Missense_Mutation_p.V202M|MED16_uc010xfv.1_Intron|MED16_uc010xfw.1_Missense_Mutation_p.V202M|MED16_uc010xfx.1_Intron|MED16_uc010xfy.1_Intron	NM_005481	NP_005472	Q9Y2X0	MED16_HUMAN	mediator complex subunit 16	213	WD 2.				androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	receptor activity|thyroid hormone receptor binding|thyroid hormone receptor coactivator activity|vitamin D receptor binding				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCAGGGCCACGCGGCCGCGC	0.716		NaN											0	0	0	0.004672	0	3	18									
DOT1L	84444	broad.mit.edu	37	19	2191089	2191089	+	Missense_Mutation	SNP	T	T	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08			T	A	T	T		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr19:2191089T>A	uc002lvb.3	+	5	379	c.343T>A	c.(343-345)TAC>AAC	p.Y115N		NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	115						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCAGCAGGTCTACAACCACTC	0.642		NaN											0	0	0	0.013537	0	13	10									
SAFB2	9667	broad.mit.edu	37	19	5600272	5600272	+	Splice_Site	SNP	C	C	G			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr19:5600272C>G	uc002mcd.2	-	12	1772	c.1560_splice	c.e12-1	p.K520_splice		NM_014649	NP_055464	Q14151	SAFB2_HUMAN	scaffold attachment factor B2						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding				0				UCEC - Uterine corpus endometrioid carcinoma (162;0.000228)		AATTACAGTTCTATTTAAAGA	0.413		NaN											0	0	0	0.000602	0	4	19									
CCDC151	115948	broad.mit.edu	37	19	11537068	11537068	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr19:11537068C>G	uc002mrs.2	-	7	1002	c.859G>C	c.(859-861)GAG>CAG	p.E287Q	CCDC151_uc002mrr.2_Missense_Mutation_p.E222Q|CCDC151_uc010dxz.2_Missense_Mutation_p.E227Q	NM_145045	NP_659482	A5D8V7	CC151_HUMAN	coiled-coil domain containing 151	287	Potential.									ovary(1)	1						AAGGTCTCCTCTAGGTACTGC	0.622		NaN											0	0	0	0.006214	0	8	33									
C19orf56	51398	broad.mit.edu	37	19	12779345	12779345	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr19:12779345C>T	uc002mud.2	-	3	491	c.243G>A	c.(241-243)ATG>ATA	p.M81I	MAN2B1_uc002mub.2_5'Flank|MAN2B1_uc010dyv.1_5'Flank|WDR83_uc002mue.3_5'UTR|WDR83_uc002muc.2_RNA|WDR83_uc010dyw.2_5'Flank	NM_016145	NP_057229	Q9Y284	CS056_HUMAN	hypothetical protein LOC51398	81	Helical; (Potential).					integral to membrane					0						TGAAGCTACTCATCATTTGCT	0.537		NaN											0	0	0	0.00278	0	19	33									
C19orf56	51398	broad.mit.edu	37	19	12779348	12779348	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr19:12779348C>T	uc002mud.2	-	3	488	c.240G>A	c.(238-240)ATG>ATA	p.M80I	MAN2B1_uc002mub.2_5'Flank|MAN2B1_uc010dyv.1_5'Flank|WDR83_uc002mue.3_5'UTR|WDR83_uc002muc.2_RNA|WDR83_uc010dyw.2_5'Flank	NM_016145	NP_057229	Q9Y284	CS056_HUMAN	hypothetical protein LOC51398	80	Helical; (Potential).					integral to membrane					0						AGCTACTCATCATTTGCTTCG	0.542		NaN											0	0	0	0.00333	0	19	34									
C19orf56	51398	broad.mit.edu	37	19	12779429	12779429	+	Silent	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr19:12779429C>T	uc002mud.2	-	3	407	c.159G>A	c.(157-159)CTG>CTA	p.L53L	MAN2B1_uc002mub.2_5'Flank|MAN2B1_uc010dyv.1_5'Flank|WDR83_uc002mue.3_5'UTR|WDR83_uc002muc.2_RNA|WDR83_uc010dyw.2_5'Flank	NM_016145	NP_057229	Q9Y284	CS056_HUMAN	hypothetical protein LOC51398	53	Helical; (Potential).					integral to membrane					0						CACACCACTTCAGCTAGGGAA	0.522		NaN											0	0	0	0.007413	0	15	37									
IL27RA	9466	broad.mit.edu	37	19	14150702	14150702	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr19:14150702C>T	uc002mxx.2	+	4	937	c.514C>T	c.(514-516)CAG>TAG	p.Q172*		NM_004843	NP_004834	Q6UWB1	I27RA_HUMAN	class I cytokine receptor precursor	172	Extracellular (Potential).|Fibronectin type-III 1.				cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity				0						CCGAAGATGTCAGGAGGCGGC	0.587		NaN											0	0	0	0.013114	0	34	230									
SLC25A42	284439	broad.mit.edu	37	19	19216402	19216402	+	Silent	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr19:19216402C>T	uc002nlf.1	+	5	397	c.246C>T	c.(244-246)CTC>CTT	p.L82L	SLC25A42_uc010xqn.1_Silent_p.L134L	NM_178526	NP_848621	Q86VD7	S2542_HUMAN	solute carrier family 25, member 42	82	Solcar 1.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0			OV - Ovarian serous cystadenocarcinoma(5;5.4e-06)|Epithelial(12;0.000497)			ACACCTACCTCAACGAGGGAT	0.627		NaN											0	0	0	0.012319	0	18	37									
SLC25A42	284439	broad.mit.edu	37	19	19217162	19217162	+	Silent	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr19:19217162C>T	uc002nlf.1	+	6	616	c.465C>T	c.(463-465)GTC>GTT	p.V155V	SLC25A42_uc010xqn.1_Silent_p.V207V	NM_178526	NP_848621	Q86VD7	S2542_HUMAN	solute carrier family 25, member 42	155	Helical; Name=3; (Potential).|Solcar 2.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0			OV - Ovarian serous cystadenocarcinoma(5;5.4e-06)|Epithelial(12;0.000497)			TGGACCTGGTCAGAGCGCGGA	0.662		NaN											0	0	0	0.003954	0	25	62									
PLAUR	5329	broad.mit.edu	37	19	44169569	44169569	+	Nonsense_Mutation	SNP	G	G	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr19:44169569G>T	uc002oxf.1	-	3	439	c.209C>A	c.(208-210)TCA>TAA	p.S70*	PLAUR_uc002oxd.1_Nonsense_Mutation_p.S70*|PLAUR_uc002oxe.1_Nonsense_Mutation_p.S65*|PLAUR_uc002oxg.1_Nonsense_Mutation_p.S70*	NM_002659	NP_002650	Q03405	UPAR_HUMAN	plasminogen activator, urokinase receptor	70	UPAR/Ly6 1.				attachment of GPI anchor to protein|blood coagulation|C-terminal protein lipidation|cellular component movement|chemotaxis|fibrinolysis|regulation of proteolysis	anchored to membrane|cell surface|endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region|extrinsic to membrane|integral to membrane|plasma membrane	enzyme binding|U-plasminogen activator receptor activity			ovary(1)	1		Prostate(69;0.0153)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Streptokinase(DB00086)|Tenecteplase(DB00031)|Urokinase(DB00013)	GGTCTTCTCTGAGTGGGTACA	0.542		NaN											1	0	1.8453e-21	0.010771	1.96942e-21	33	61									
ZNF226	7769	broad.mit.edu	37	19	44681738	44681738	+	Missense_Mutation	SNP	A	A	G			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr19:44681738A>G	uc002oyp.2	+	6	2467	c.2323A>G	c.(2323-2325)AGA>GGA	p.R775G	ZNF226_uc002oyq.2_Missense_Mutation_p.R658G|ZNF226_uc002oyr.2_Missense_Mutation_p.R658G|ZNF226_uc010ejg.2_3'UTR|ZNF226_uc002oys.2_Missense_Mutation_p.R775G|ZNF226_uc002oyt.2_Missense_Mutation_p.R775G	NM_001032373	NP_001027545	Q9NYT6	ZN226_HUMAN	zinc finger protein 226 isoform a	775	C2H2-type 19.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)				AGTTCATCACAGAATCCATGT	0.368		NaN											0	0	0	0.000602	0	5	56									
SPHK2	56848	broad.mit.edu	37	19	49132307	49132307	+	Silent	SNP	A	A	C			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr19:49132307A>C	uc002pjr.2	+	7	1608	c.1242A>C	c.(1240-1242)TCA>TCC	p.S414S	SPHK2_uc010xzt.1_Silent_p.S355S|SPHK2_uc002pjs.2_Silent_p.S414S|SPHK2_uc002pjt.2_Silent_p.S208S|SPHK2_uc002pju.2_Intron|SPHK2_uc002pjv.2_Silent_p.S378S|SPHK2_uc002pjw.2_Silent_p.S476S	NM_020126	NP_064511	Q9NRA0	SPHK2_HUMAN	sphingosine kinase 2	414					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cell proliferation|sphinganine-1-phosphate biosynthetic process	cytosol|lysosomal membrane|membrane fraction	ATP binding|D-erythro-sphingosine kinase activity|diacylglycerol kinase activity|Ras GTPase binding|sphinganine kinase activity			lung(1)	1		all_lung(116;0.000125)|Lung NSC(112;0.000202)|all_epithelial(76;0.000283)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		tggcccactcacccctgcatc	0.338		NaN											0	0	0	0.001984	0	5	20									
HSD17B14	51171	broad.mit.edu	37	19	49334931	49334931	+	Silent	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr19:49334931C>T	uc002pkv.1	-	5	629	c.363G>A	c.(361-363)TTG>TTA	p.L121L	HSD17B14_uc010emk.1_Silent_p.L121L	NM_016246	NP_057330	Q9BPX1	DHB14_HUMAN	dehydrogenase/reductase (SDR family) member 10	121					steroid catabolic process	centrosome|cytosol	estradiol 17-beta-dehydrogenase activity|protein binding|testosterone 17-beta-dehydrogenase (NADP+) activity				0		all_epithelial(76;7e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000341)|all cancers(93;0.000764)|GBM - Glioblastoma multiforme(486;0.0233)|Epithelial(262;0.0346)		TCACCTTGGTCAAGGTGTACG	0.587		NaN											0	0	0	0.006999	0	36	95									
ZNF615	284370	broad.mit.edu	37	19	52496893	52496893	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr19:52496893G>C	uc002pye.1	-	6	1728	c.1436C>G	c.(1435-1437)ACT>AGT	p.T479S	ZNF615_uc002pyf.1_Missense_Mutation_p.T490S|ZNF615_uc002pyg.1_Missense_Mutation_p.T371S|ZNF615_uc002pyh.1_Missense_Mutation_p.T490S|ZNF615_uc010epi.1_Missense_Mutation_p.T486S|ZNF615_uc010ydg.1_Missense_Mutation_p.T484S	NM_198480	NP_940882	Q8N8J6	ZN615_HUMAN	zinc finger protein 615	479					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		CTTCTCTGCAGTATGAGTTCG	0.438		NaN											0	0	0	0.004672	0	3	20									
NLRP4	147945	broad.mit.edu	37	19	56369402	56369402	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr19:56369402C>T	uc002qmd.3	+	3	1065	c.643C>T	c.(643-645)CCT>TCT	p.P215S	NLRP4_uc002qmf.2_Missense_Mutation_p.P140S|NLRP4_uc010etf.2_Missense_Mutation_p.P46S	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	215	NACHT.						ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		CCCCGCTGCTCCTATAACAGA	0.537		NaN											0	0	0	0.005524	0	34	80									
ZNF776	284309	broad.mit.edu	37	19	58265972	58265972	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr19:58265972G>C	uc002qpx.2	+	3	1697	c.1474G>C	c.(1474-1476)GAA>CAA	p.E492Q	ZNF587_uc002qqb.2_Intron|ZNF776_uc002qqa.2_Missense_Mutation_p.E492Q	NM_173632	NP_775903	Q68DI1	ZN776_HUMAN	zinc finger protein 776	492	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0256)		TGAGTGTGGAGAATGTGGAAA	0.428		NaN											0	0	0	0.010818	0	29	68									
APOB	338	broad.mit.edu	37	2	21258577	21258577	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr2:21258577G>A	uc002red.2	-	7	825	c.697C>T	c.(697-699)CGC>TGC	p.R233C		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	233	Vitellogenin.|Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GACAAGGGGCGGGTCTATGAA	0.498		NaN											0	0	0	0.00632	0	23	29									
DHX57	90957	broad.mit.edu	37	2	39085813	39085813	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr2:39085813C>G	uc002rrf.2	-	6	1676	c.1577G>C	c.(1576-1578)CGA>CCA	p.R526P	DHX57_uc002rre.2_5'UTR|DHX57_uc002rrg.2_Missense_Mutation_p.R526P	NM_198963	NP_945314	Q6P158	DHX57_HUMAN	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	526							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		all_hematologic(82;0.248)				CTGTTTCATTCGGAACTGCTT	0.408		NaN											0	0	0	0.01441	0	63	295									
FOXN2	3344	broad.mit.edu	37	2	48602364	48602364	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr2:48602364G>A	uc002rwh.1	+	7	1393	c.1078G>A	c.(1078-1080)GAT>AAT	p.D360N		NM_002158	NP_002149	P32314	FOXN2_HUMAN	T-cell leukemia virus enhancer factor	360					embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.0272)|LUSC - Lung squamous cell carcinoma(58;0.036)			TTATGAAGATGATCCTCTTGG	0.413		NaN											0	0	0	0.014323	0	21	74									
STON1-GTF2A1L	286749	broad.mit.edu	37	2	48874053	48874053	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr2:48874053C>G	uc010yol.1	+	5	2868	c.2821C>G	c.(2821-2823)CAT>GAT	p.H941D	STON1-GTF2A1L_uc002rwp.1_Missense_Mutation_p.H988D|GTF2A1L_uc002rws.1_Missense_Mutation_p.H284D|GTF2A1L_uc010yom.1_Missense_Mutation_p.H250D|GTF2A1L_uc002rwt.2_Missense_Mutation_p.H284D	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	941					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			CACAAGCCCTCATGGGGCTCT	0.438		NaN											0	0	0	0.00499	0	14	55									
LHCGR	3973	broad.mit.edu	37	2	48925887	48925887	+	Missense_Mutation	SNP	T	T	C			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr2:48925887T>C	uc002rwu.3	-	9	803	c.733A>G	c.(733-735)ATT>GTT	p.I245V	GTF2A1L_uc002rwt.2_Intron|LHCGR_uc002rwv.2_RNA	NM_000233	NP_000224	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	245	Extracellular (Potential).				male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			ovary(3)|lung(2)|breast(2)|skin(1)	8		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	AGCCTCTGAATGGACTCTAGG	0.413		NaN							Familial_Male-Limited_Precocious_Puberty				0	0	0	0.003271	0	29	45									
ELMOD3	84173	broad.mit.edu	37	2	85604471	85604471	+	Silent	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr2:85604471G>A	uc002spf.3	+	12	1277	c.612G>A	c.(610-612)GCG>GCA	p.A204A	ELMOD3_uc010fgg.2_RNA|ELMOD3_uc002spg.3_Silent_p.A204A|ELMOD3_uc002sph.3_Silent_p.A204A|ELMOD3_uc010ysn.1_Silent_p.A204A|ELMOD3_uc010yso.1_RNA|ELMOD3_uc010ysp.1_RNA	NM_001135021	NP_001128493	Q96FG2	ELMD3_HUMAN	ELMO/CED-12 domain containing 3 isoform b	204	ELMO.				phagocytosis	cytoskeleton				ovary(2)	2						TTACAGGAGCGAATCCAGCCA	0.587		NaN											0	0	0	0.00245	0	12	61									
UGGT1	56886	broad.mit.edu	37	2	128945037	128945037	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr2:128945037G>A	uc002tps.2	+	40	4669	c.4491G>A	c.(4489-4491)ATG>ATA	p.M1497I	UGGT1_uc002tpr.2_Missense_Mutation_p.M1473I	NM_020120	NP_064505	Q9NYU2	UGGG1_HUMAN	UDP-glucose ceramide glucosyltransferase-like 1	1497	Glucosyltransferase (By similarity).				'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			ovary(1)	1						ATAATCCGATGACCAAAGAGC	0.463		NaN											0	0	0	0.010729	0	10	80									
MCM6	4175	broad.mit.edu	37	2	136603937	136603937	+	Silent	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr2:136603937C>T	uc002tuw.2	-	15	2155	c.2079G>A	c.(2077-2079)GTG>GTA	p.V693V		NM_005915	NP_005906	Q14566	MCM6_HUMAN	minichromosome maintenance complex component 6	693					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|identical protein binding				0				BRCA - Breast invasive adenocarcinoma(221;0.166)	Atorvastatin(DB01076)	TGATCCCGTTCACAGGAGCAG	0.443		NaN											0	0	0	0.01441	0	154	146									
SCN9A	6335	broad.mit.edu	37	2	167056103	167056103	+	Silent	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr2:167056103C>T	uc010fpl.2	-	27	5354	c.5013G>A	c.(5011-5013)GAG>GAA	p.E1671E	uc002udp.2_Intron	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	1682	IV.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	TGCCAAAGGTCTCAAAATTGA	0.428		NaN											0	0	0	0.01441	0	61	114									
FRZB	2487	broad.mit.edu	37	2	183730874	183730874	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr2:183730874C>T	uc002upa.1	-	1	625	c.407G>A	c.(406-408)TGC>TAC	p.C136Y		NM_001463	NP_001454	Q92765	SFRP3_HUMAN	frizzled-related protein precursor	136	FZ.				brain development|cochlea morphogenesis|gonad development|mammary gland involution|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cartilage development|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of hepatocyte differentiation|positive regulation of apoptosis|positive regulation of fat cell differentiation|skeletal system development|vasculature development|Wnt receptor signaling pathway	cytoplasm|extracellular space|membrane	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			ovary(2)|lung(1)|central_nervous_system(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.109)|Epithelial(96;0.231)			CAGCTCCTCGCAGGCCAGGTT	0.637		NaN											0	0	0	0.006214	0	9	23									
ANKAR	150709	broad.mit.edu	37	2	190554293	190554293	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr2:190554293C>G	uc002uqw.1	+	2	429	c.429C>G	c.(427-429)ATC>ATG	p.I143M	ANKAR_uc002uqu.2_RNA|ANKAR_uc002uqv.1_Missense_Mutation_p.I214M	NM_144708	NP_653309	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	214						integral to membrane	binding			ovary(2)|pancreas(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			TTAATGAAATCTATGATGAAG	0.303		NaN											0	0	0	0.003271	0	28	85									
SATB2	23314	broad.mit.edu	37	2	200173580	200173580	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr2:200173580G>A	uc002uuy.1	-	10	2460	c.1643C>T	c.(1642-1644)CCC>CTC	p.P548L	SATB2_uc010fsq.1_Missense_Mutation_p.P430L|SATB2_uc002uuz.1_Missense_Mutation_p.P548L|SATB2_uc002uva.1_Missense_Mutation_p.P548L	NM_015265	NP_056080	Q9UPW6	SATB2_HUMAN	SATB homeobox 2	548	CUT 2.					cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			ovary(1)	1						CTCATGCTGGGGAAGGTTCAG	0.587		NaN											0	0	0	0.007835	0	39	97									
NOP58	51602	broad.mit.edu	37	2	203152401	203152401	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr2:203152401G>T	uc002uzb.2	+	6	603	c.453G>T	c.(451-453)TTG>TTT	p.L151F		NM_015934	NP_057018	Q9Y2X3	NOP58_HUMAN	NOP58 ribonucleoprotein homolog	151					cell growth|rRNA processing|snRNP protein import into nucleus	box C/D snoRNP complex|Cajal body|cytoplasm|pre-snoRNP complex	protein binding|snoRNA binding				0						GATATAGATTGAAGTTTAGCG	0.348		NaN											1	0	1.51926e-22	0.01441	1.62875e-22	37	119									
MARCH4	57574	broad.mit.edu	37	2	217124125	217124125	+	Silent	SNP	G	G	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr2:217124125G>T	uc002vgb.2	-	4	2910	c.1143C>A	c.(1141-1143)ATC>ATA	p.I381I		NM_020814	NP_065865	Q9P2E8	MARH4_HUMAN	membrane-associated ring finger (C3HC4) 4	381						Golgi membrane|Golgi stack|integral to membrane|trans-Golgi network	ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Renal(323;0.0854)		Epithelial(149;2.19e-05)|all cancers(144;0.00121)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(261;0.0125)		GGATGTGCAGGATGGTATAAG	0.627		NaN											1	0	6.29468e-14	0.004878	6.57077e-14	33	41									
WNT6	7475	broad.mit.edu	37	2	219736442	219736442	+	Silent	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr2:219736442G>A	uc002vjc.1	+	3	752	c.537G>A	c.(535-537)GGG>GGA	p.G179G		NM_006522	NP_006513	Q9Y6F9	WNT6_HUMAN	wingless-type MMTV integration site family,	179					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|cornea development in camera-type eye|neuron differentiation|odontogenesis of dentine-containing tooth|positive regulation of gene expression|positive regulation of tooth mineralization|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			ovary(2)|skin(1)	3		Renal(207;0.0474)		Epithelial(149;4.53e-07)|all cancers(144;9.3e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGGACTTCGGGGACGAGAAGT	0.547		NaN											0	0	0	0.001984	0	5	12									
CCDC108	255101	broad.mit.edu	37	2	219886644	219886644	+	Silent	SNP	T	T	C			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr2:219886644T>C	uc002vjl.1	-	18	3072	c.2988A>G	c.(2986-2988)GAA>GAG	p.E996E	CCDC108_uc002vjm.3_5'Flank	NM_194302	NP_919278	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108 isoform 1	996						integral to membrane	structural molecule activity			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCAGCTCCTTTTCCTTTGCCT	0.597		NaN											0	0	0	0.01441	0	118	19									
UGT1A3	54659	broad.mit.edu	37	2	234638530	234638530	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr2:234638530C>T	uc002vuy.2	+	1	758	c.758C>T	c.(757-759)TCT>TTT	p.S253F	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Intron|UGT1A4_uc002vux.2_Intron|UGT1A3_uc010znb.1_Missense_Mutation_p.S253F	NM_019093	NP_061966	P35503	UD13_HUMAN	UDP glycosyltransferase 1 family, polypeptide A3	253					flavonoid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding			ovary(1)	1		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;2.4e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000476)|Lung(119;0.00243)|LUSC - Lung squamous cell carcinoma(224;0.00599)		AGTCATGCATCTGTGTGGCTG	0.507		NaN											0	0	0	0.00623	0	33	213									
CEP250	11190	broad.mit.edu	37	20	34063379	34063379	+	Silent	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr20:34063379C>T	uc002xcm.2	+	16	2295	c.1624C>T	c.(1624-1626)CTG>TTG	p.L542L	CEP250_uc010zve.1_5'UTR|CEP250_uc010zvd.1_Intron	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	542	Gln/Glu-rich.|Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			ACTCAGTGAACTGATCACTCT	0.552		NaN											0	0	0	0.01441	0	76	199									
PRIC285	85441	broad.mit.edu	37	20	62198304	62198304	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr20:62198304C>T	uc002yfm.2	-	7	3299	c.2407G>A	c.(2407-2409)GAG>AAG	p.E803K	PRIC285_uc002yfl.1_Missense_Mutation_p.E234K	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	803					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			TGCGCAATCTCAGCCAGATTC	0.662		NaN											0	0	0	0.004289	0	29	137									
PRIC285	85441	broad.mit.edu	37	20	62198314	62198314	+	Silent	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr20:62198314C>T	uc002yfm.2	-	7	3289	c.2397G>A	c.(2395-2397)CTG>CTA	p.L799L	PRIC285_uc002yfl.1_Silent_p.L230L	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	799					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			CAGCCAGATTCAGCCAGGACG	0.672		NaN											0	0	0	0.003271	0	27	131									
RIPK4	54101	broad.mit.edu	37	21	43161772	43161772	+	Silent	SNP	G	G	A	rs143300354		TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr21:43161772G>A	uc002yzn.1	-	8	1629	c.1581C>T	c.(1579-1581)AAC>AAT	p.N527N		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3	527						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7						TGACCGAGGCGTTCTTCTCCA	0.627		NaN											0	0	0	0.010729	0	12	55									
GGT1	2678	broad.mit.edu	37	22	25023476	25023476	+	Silent	SNP	C	C	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr22:25023476C>A	uc003aan.1	+	12	1585	c.1098C>A	c.(1096-1098)ATC>ATA	p.I366I	GGT1_uc003aas.1_Silent_p.I366I|GGT1_uc003aat.1_Silent_p.I366I|GGT1_uc003aau.1_Silent_p.I366I|GGT1_uc003aav.1_Silent_p.I366I|GGT1_uc003aaw.1_Silent_p.I366I|GGT1_uc003aax.1_Silent_p.I366I|GGT1_uc003aay.1_Silent_p.I22I	NM_013430	NP_038347	P19440	GGT1_HUMAN	gamma-glutamyltransferase 1 precursor	366	Extracellular (Potential).				glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity|protein binding				0					Glutathione(DB00143)	CTCACCCGATCTCCTACTACA	0.642		NaN											1	0	6.68952e-21	0.013114	7.10762e-21	35	81									
SSTR3	6753	broad.mit.edu	37	22	37603104	37603104	+	Missense_Mutation	SNP	G	G	A	rs146500640	byFrequency	TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr22:37603104G>A	uc003ara.2	-	2	801	c.739C>T	c.(739-741)CGG>TGG	p.R247W	SSTR3_uc003arb.2_Missense_Mutation_p.R247W	NM_001051	NP_001042	P32745	SSR3_HUMAN	somatostatin receptor 3	247	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|induction of apoptosis by hormones|negative regulation of cell proliferation	integral to plasma membrane|nonmotile primary cilium	somatostatin receptor activity			lung(1)	1						CGCCGCCGCCGCTGGCACGAG	0.672		NaN											0	0	0	0.00333	0	16	31									
PMM1	5372	broad.mit.edu	37	22	41982104	41982104	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr22:41982104C>T	uc003bal.2	-	2	243	c.181G>A	c.(181-183)GAG>AAG	p.E61K		NM_002676	NP_002667	Q92871	PMM1_HUMAN	phosphomannomutase 1	61					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol	metal ion binding|phosphomannomutase activity			ovary(1)	1						CCCAGCTGCTCAGCGATCTTA	0.567		NaN											0	0	0	0.01441	0	53	129									
PMM1	5372	broad.mit.edu	37	22	41982185	41982185	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr22:41982185C>G	uc003bal.2	-	2	162	c.100G>C	c.(100-102)GAG>CAG	p.E34Q		NM_002676	NP_002667	Q92871	PMM1_HUMAN	phosphomannomutase 1	34					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol	metal ion binding|phosphomannomutase activity			ovary(1)	1						GCGGCCACCTCAGGGTCAATT	0.562		NaN											0	0	0	0.01441	0	43	149									
ITPR1	3708	broad.mit.edu	37	3	4712527	4712527	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr3:4712527G>C	uc003bqa.2	+	20	2469	c.2121G>C	c.(2119-2121)GAG>GAC	p.E707D	ITPR1_uc010hca.1_Missense_Mutation_p.E692D|ITPR1_uc011asu.1_Intron|ITPR1_uc010hcb.1_Missense_Mutation_p.E692D	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	707	Cytoplasmic (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		GCAACAAAGAGATTCGCAGCA	0.517		NaN											0	0	0	0.004482	0	9	35									
SLC6A6	6533	broad.mit.edu	37	3	14508095	14508095	+	Silent	SNP	G	G	C			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr3:14508095G>C	uc010heg.2	+	14	1095	c.804G>C	c.(802-804)CCG>CCC	p.P268P	SLC6A6_uc003byq.2_Silent_p.P268P|SLC6A6_uc003byr.2_RNA	NM_001134367	NP_001127839	P31641	SC6A6_HUMAN	solute carrier family 6 (neurotransmitter	268					cellular amino acid metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity|taurine:sodium symporter activity			ovary(1)	1						TGACGCTGCCGGGCGCGGGCG	0.617		NaN											0	0	0	0.004289	0	31	41									
NR2C2	7182	broad.mit.edu	37	3	15045491	15045491	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr3:15045491C>T	uc003bzj.3	+	2	287	c.70C>T	c.(70-72)CAG>TAG	p.Q24*	NR2C2_uc003bzi.2_Nonsense_Mutation_p.Q24*	NM_003298	NP_003289	P49116	NR2C2_HUMAN	nuclear receptor subfamily 2, group C, member 2	24					cell differentiation|nervous system development|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|spermatogenesis	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding				0						TCAGCGCATTCAGGTACCTGC	0.527		NaN											0	0	0	0.00632	0	23	129									
BAP1	8314	broad.mit.edu	37	3	52439230	52439230	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr3:52439230G>A	uc003ddx.2	-	11	1127	c.1012C>T	c.(1012-1014)CCT>TCT	p.P338S	BAP1_uc003ddw.2_5'Flank|BAP1_uc010hmg.2_5'Flank|BAP1_uc010hmh.2_5'Flank	NM_004656	NP_004647	Q92560	BAP1_HUMAN	BRCA1 associated protein-1	338					monoubiquitinated histone H2A deubiquitination|negative regulation of cell proliferation|protein K48-linked deubiquitination|regulation of cell cycle|regulation of cell growth|ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|PR-DUB complex	chromatin binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			pleura(32)|eye(28)|lung(2)|ovary(2)|breast(1)	65				BRCA - Breast invasive adenocarcinoma(193;1.72e-05)|Kidney(197;0.0018)|KIRC - Kidney renal clear cell carcinoma(197;0.00203)|OV - Ovarian serous cystadenocarcinoma(275;0.0277)		CTGCCTGGAGGCTTCACCACT	0.587		NaN	N|Mis|F|S|O		uveal melanoma|breast|NSCLC								0	0	0	0.01441	0	85	106									
SEMA3G	56920	broad.mit.edu	37	3	52474095	52474095	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr3:52474095G>T	uc003dea.1	-	11	1163	c.1163C>A	c.(1162-1164)GCA>GAA	p.A388E		NM_020163	NP_064548	Q9NS98	SEM3G_HUMAN	semaphorin sem2 precursor	388	Sema.				multicellular organismal development	extracellular region|membrane	receptor activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;1.69e-05)|Kidney(197;0.00173)|KIRC - Kidney renal clear cell carcinoma(197;0.00196)|OV - Ovarian serous cystadenocarcinoma(275;0.0333)		TCCTGGCTGTGCGGTCATCTT	0.622		NaN											1	0	1.15088e-07	0.004007	1.18575e-07	15	20									
CADM2	253559	broad.mit.edu	37	3	86115879	86115879	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr3:86115879C>G	uc003dqj.2	+	10	1880	c.1254C>G	c.(1252-1254)ATC>ATG	p.I418M	CADM2_uc003dqk.2_Missense_Mutation_p.I387M|CADM2_uc003dql.2_Missense_Mutation_p.I420M|uc003dqm.1_5'Flank	NM_153184	NP_694854	Q8N3J6	CADM2_HUMAN	immunoglobulin superfamily, member 4D	418	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				ovary(1)|lung(1)|kidney(1)|skin(1)	4		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		CAGCCATTATCAATGCTGAAG	0.393		NaN											0	0	0	0.007291	0	28	36									
ZNF80	7634	broad.mit.edu	37	3	113955575	113955575	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr3:113955575C>T	uc010hqo.2	-	1	851	c.347G>A	c.(346-348)CGC>CAC	p.R116H	ZNF80_uc003ebf.2_RNA	NM_007136	NP_009067	P51504	ZNF80_HUMAN	zinc finger protein 80	116	C2H2-type 3; atypical.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Lung NSC(201;0.0233)|all_neural(597;0.0837)				GTGCGACCTGCGGTTGAAGAC	0.542		NaN											0	0	0	0.008871	0	16	29									
HPS3	84343	broad.mit.edu	37	3	148871395	148871395	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr3:148871395G>A	uc003ewu.1	+	7	1500	c.1360G>A	c.(1360-1362)GAA>AAA	p.E454K	HPS3_uc003ewt.1_Missense_Mutation_p.E454K|HPS3_uc011bnq.1_Missense_Mutation_p.E289K	NM_032383	NP_115759	Q969F9	HPS3_HUMAN	Hermansky-Pudlak syndrome 3 protein	454						cytoplasm				ovary(5)|large_intestine(1)	6			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			AGCAGAACCTGAAGCCATTCC	0.438		NaN							Hermansky-Pudlak_syndrome				0	0	0	0.014323	0	20	57									
TXK	7294	broad.mit.edu	37	4	48082134	48082134	+	Missense_Mutation	SNP	T	T	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr4:48082134T>A	uc003gxx.3	-	11	1054	c.968A>T	c.(967-969)CAT>CTT	p.H323L	TXK_uc010igj.2_RNA|TXK_uc011bzj.1_Missense_Mutation_p.H10L	NM_003328	NP_003319	P42681	TXK_HUMAN	TXK tyrosine kinase	323	Protein kinase.					cytoplasm	ATP binding|non-membrane spanning protein tyrosine kinase activity				0						TAGCTTTGAATGAGATAATTT	0.373		NaN											0	0	0	0.004482	0	8	30									
PPEF2	5470	broad.mit.edu	37	4	76797581	76797581	+	Silent	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr4:76797581G>A	uc003hix.2	-	11	1536	c.1179C>T	c.(1177-1179)TCC>TCT	p.S393S	PPEF2_uc003hiy.2_RNA|PPEF2_uc003hiz.1_Silent_p.S393S	NM_006239	NP_006230	O14830	PPE2_HUMAN	serine/threonine protein phosphatase with	393	Catalytic.				detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			ovary(2)|lung(1)|central_nervous_system(1)	4			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			CCAGTTCCACGGAGCTCCGCA	0.657		NaN											0	0	0	0.004007	0	15	21									
ANK2	287	broad.mit.edu	37	4	114284603	114284603	+	Silent	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr4:114284603G>A	uc003ibe.3	+	40	10966	c.10866G>A	c.(10864-10866)GAG>GAA	p.E3622E	ANK2_uc003ibd.3_Silent_p.E1528E|ANK2_uc003ibf.3_Silent_p.E1537E|ANK2_uc011cgc.1_Silent_p.E713E|ANK2_uc003ibg.3_Silent_p.E521E|ANK2_uc003ibh.3_Silent_p.E211E|ANK2_uc011cgd.1_Silent_p.E924E	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	3589	Death.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		ACTGGCTAGAGAGGGATGGGA	0.428		NaN											0	0	0	0.012319	0	17	123									
FGG	2266	broad.mit.edu	37	4	155531252	155531252	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr4:155531252C>T	uc003ioj.2	-	5	640	c.499G>A	c.(499-501)GAC>AAC	p.D167N	FGG_uc003iog.2_Missense_Mutation_p.D167N|FGG_uc003ioh.2_Missense_Mutation_p.D167N|FGG_uc010ipx.2_Intron|FGG_uc010ipy.2_Intron|FGG_uc003ioi.2_5'UTR|FGG_uc003iok.2_Missense_Mutation_p.D167N	NM_021870	NP_068656	P02679	FIBG_HUMAN	fibrinogen, gamma chain isoform gamma-B	167					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding				0	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	TGCACCGTGTCTTTGCAAGGT	0.363		NaN											0	0	0	0.004878	0	33	47									
CCDC110	256309	broad.mit.edu	37	4	186380148	186380148	+	Silent	SNP	T	T	C			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr4:186380148T>C	uc003ixu.3	-	6	1669	c.1593A>G	c.(1591-1593)CAA>CAG	p.Q531Q	CCDC110_uc003ixv.3_Silent_p.Q494Q|CCDC110_uc011ckt.1_Silent_p.Q531Q	NM_152775	NP_689988	Q8TBZ0	CC110_HUMAN	coiled-coil domain containing 110 isoform a	531	Potential.					nucleus				central_nervous_system(1)	1		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;7.86e-05)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|Colorectal(36;0.0381)|all_hematologic(60;0.0749)		OV - Ovarian serous cystadenocarcinoma(60;1.13e-10)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.00014)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00921)|COAD - Colon adenocarcinoma(29;0.0105)|READ - Rectum adenocarcinoma(43;0.164)		CTAAAGAAAGTTGTATATTTT	0.264		NaN											0	0	0	0.014323	0	23	8									
IRX1	79192	broad.mit.edu	37	5	3600252	3600252	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr5:3600252C>T	uc003jde.2	+	2	1242	c.1190C>T	c.(1189-1191)CCC>CTC	p.P397L		NM_024337	NP_077313	P78414	IRX1_HUMAN	iroquois homeobox protein 1	397						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2						GTTGGCGCTCCCCACGCCGCG	0.662		NaN											0	0	0	0.003163	0	12	63									
FASTKD3	79072	broad.mit.edu	37	5	7861273	7861273	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr5:7861273G>C	uc003jeb.2	-	6	2010	c.1873C>G	c.(1873-1875)CAA>GAA	p.Q625E	FASTKD3_uc011cmp.1_Missense_Mutation_p.Q327E|FASTKD3_uc003jec.2_RNA	NM_024091	NP_076996	Q14CZ7	FAKD3_HUMAN	FAST kinase domains 3	625	RAP.				apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(2)|breast(1)|pancreas(1)	4						TGAACAACTTGATAACCGAGT	0.323		NaN											0	0	0	0.01441	0	53	68									
RAD17	5884	broad.mit.edu	37	5	68684860	68684860	+	Splice_Site	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr5:68684860G>A	uc003jwo.2	+	9	990	c.928_splice	c.e9-1	p.N310_splice	RAD17_uc003jwg.2_Splice_Site_p.N299_splice|RAD17_uc003jwh.2_Splice_Site_p.N299_splice|RAD17_uc003jwi.2_Splice_Site_p.N299_splice|RAD17_uc003jwj.2_Splice_Site_p.N299_splice|RAD17_uc003jwk.2_Splice_Site_p.N299_splice|RAD17_uc003jwl.2_Splice_Site_p.N299_splice|RAD17_uc003jwm.2_Splice_Site_p.N134_splice|RAD17_uc003jwn.2_Splice_Site_p.N213_splice	NM_133339	NP_579917	O75943	RAD17_HUMAN	RAD17 homolog isoform 2						cell cycle|DNA damage checkpoint|DNA repair|DNA replication|DNA replication checkpoint|mitotic cell cycle checkpoint|negative regulation of DNA replication|regulation of phosphorylation	nucleoplasm	ATP binding|nucleoside-triphosphatase activity|protein binding				0		Lung NSC(167;5.19e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;9.36e-57)|Epithelial(20;1.21e-52)|all cancers(19;3.34e-48)|Lung(70;0.0183)		tcttattttaGAATGGAGGAA	0.279		NaN						Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					0	0	0	0.009096	0	4	34									
LYSMD3	116068	broad.mit.edu	37	5	89815210	89815210	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr5:89815210G>A	uc003kjr.2	-	3	495	c.347C>T	c.(346-348)TCC>TTC	p.S116F	LYSMD3_uc010jaz.1_Intron|LYSMD3_uc003kjs.1_Silent_p.F96F	NM_198273	NP_938014	Q7Z3D4	LYSM3_HUMAN	LysM, putative peptidoglycan-binding, domain	116	Extracellular (Potential).				cell wall macromolecule catabolic process	integral to membrane					0		all_cancers(142;5.03e-09)|all_epithelial(76;1.23e-11)|Lung NSC(167;2.46e-05)|all_lung(232;3.25e-05)|Ovarian(174;0.00832)|Colorectal(57;0.122)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(54;1.94e-31)|Epithelial(54;5.22e-26)|all cancers(79;2.42e-22)		TTCGGTCAAGGAACTGAACTT	0.398		NaN											0	0	0	0.007291	0	25	58									
CLTB	1212	broad.mit.edu	37	5	175823491	175823491	+	Silent	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr5:175823491G>A	uc003meh.2	-	6	682	c.507C>T	c.(505-507)ATC>ATT	p.I169I	CLTB_uc003mei.2_Intron|CLTB_uc011dfn.1_Intron	NM_007097	NP_009028	P09497	CLCB_HUMAN	clathrin, light polypeptide isoform b	169					intracellular protein transport|vesicle-mediated transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle	protein binding|structural molecule activity				0	all_cancers(89;0.00522)|Renal(175;0.000269)|Lung NSC(126;0.0105)|all_lung(126;0.0168)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Kidney(146;0.098)		CGTAGCCGATGATATCAGCAT	0.348		NaN											0	0	0	0.012319	0	19	32									
RGS14	10636	broad.mit.edu	37	5	176793178	176793178	+	Missense_Mutation	SNP	A	A	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr5:176793178A>T	uc003mgf.2	+	3	250	c.68A>T	c.(67-69)GAG>GTG	p.E23V	RGS14_uc003mgg.1_5'Flank|RGS14_uc003mgh.2_5'Flank|RGS14_uc003mgi.2_5'Flank	NM_006480	NP_006471	O43566	RGS14_HUMAN	regulator of G-protein signalling 14	23					chromosome segregation|long-term memory|long-term synaptic potentiation|negative regulation of ERK1 and ERK2 cascade|negative regulation of MAP kinase activity|negative regulation of synaptic plasticity|nucleocytoplasmic transport|platelet-derived growth factor receptor signaling pathway|positive regulation of neurogenesis|regulation of DNA-dependent transcription in response to stress|regulation of G-protein coupled receptor protein signaling pathway|response to oxidative stress|spindle organization|visual learning|zygote asymmetric cell division	cell junction|centrosome|dendritic spine|microtubule|PML body|postsynaptic density|postsynaptic membrane|spindle pole	GDP-dissociation inhibitor activity|GTPase activator activity|microtubule binding|receptor signaling complex scaffold activity|receptor signaling protein activity			lung(1)	1	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCCCCTGCAGAGCTGAGCAGC	0.682		NaN											0	0	0	0.001855	0	9	33									
HIST1H3I	8354	broad.mit.edu	37	6	27839778	27839778	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr6:27839778C>G	uc003njy.2	-	1	322	c.316G>C	c.(316-318)GAG>CAG	p.E106Q		NM_003533	NP_003524	P68431	H31_HUMAN	histone cluster 1, H3i	106					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						TTGGTATCCTCAAATAGCCCC	0.572		NaN											0	0	0	0.01441	0	58	82									
CDSN	1041	broad.mit.edu	37	6	31084799	31084799	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr6:31084799G>C	uc003nsm.1	-	2	620	c.593C>G	c.(592-594)TCT>TGT	p.S198C	PSORS1C1_uc003nsl.1_Intron|PSORS1C1_uc010jsj.1_Intron	NM_001264	NP_001255	Q15517	CDSN_HUMAN	corneodesmosin precursor	198	Ser-rich.				cell-cell adhesion|keratinocyte differentiation|skin morphogenesis	cornified envelope|desmosome|extracellular region	protein homodimerization activity			ovary(1)|pancreas(1)	2						GGTCTGGGAAGAGGAAGAGCT	0.572		NaN											0	0	0	0.01441	0	11	106									
FAM46A	55603	broad.mit.edu	37	6	82459570	82459570	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr6:82459570C>T	uc003pjg.2	-	3	1489	c.1171G>A	c.(1171-1173)GAC>AAC	p.D391N	FAM46A_uc003pjf.2_Missense_Mutation_p.D410N	NM_017633	NP_060103	Q96IP4	FA46A_HUMAN	hypothetical protein LOC55603	391											0		all_cancers(76;6.74e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000282)|all_epithelial(107;0.0104)		BRCA - Breast invasive adenocarcinoma(397;0.0428)		ACATTTTGGTCAGCTAACACC	0.453		NaN											0	0	0	0.01441	0	52	10									
CASP8AP2	9994	broad.mit.edu	37	6	90573259	90573259	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr6:90573259G>A	uc003pnr.2	+	7	2027	c.1831G>A	c.(1831-1833)GAA>AAA	p.E611K	CASP8AP2_uc003pns.2_Intron|CASP8AP2_uc003pnt.2_Missense_Mutation_p.E611K|CASP8AP2_uc011dzz.1_Missense_Mutation_p.E611K	NM_001137667	NP_001131139	Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2	611					cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			ovary(2)	2		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		CTCCATAAGTGAACATATCTT	0.423		NaN											0	0	0	0.009535	0	23	2									
FUT9	10690	broad.mit.edu	37	6	96651476	96651476	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr6:96651476G>A	uc003pop.3	+	3	786	c.445G>A	c.(445-447)GAG>AAG	p.E149K		NM_006581	NP_006572	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3)	149	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			skin(4)|ovary(1)	5		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		GAGTGGCATTGAGCACTTGTT	0.453		NaN											0	0	0	0.00333	0	21	29									
SMPD2	6610	broad.mit.edu	37	6	109763792	109763792	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr6:109763792G>C	uc003pti.2	+	6	849	c.455G>C	c.(454-456)CGT>CCT	p.R152P	PPIL6_uc003ptg.3_5'Flank|PPIL6_uc010kdo.2_5'Flank|PPIL6_uc010kdp.2_5'Flank|PPIL6_uc003pth.1_5'Flank	NM_003080	NP_003071	O60906	NSMA_HUMAN	sphingomyelin phosphodiesterase 2, neutral	152					induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|sphingomyelin metabolic process	integral to plasma membrane	metal ion binding|sphingomyelin phosphodiesterase activity				0		all_cancers(87;1.1e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000144)|all_lung(197;0.0221)|Colorectal(196;0.0488)|Lung SC(18;0.0548)		Epithelial(106;0.0137)|all cancers(137;0.0188)|OV - Ovarian serous cystadenocarcinoma(136;0.0228)|BRCA - Breast invasive adenocarcinoma(108;0.0566)		CTAGCACATCGTGTGGCCCAA	0.542		NaN											0	0	0	0.008291	0	8	90									
GPER	2852	broad.mit.edu	37	7	1131766	1131766	+	Silent	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr7:1131766G>A	uc010ksd.1	+	2	791	c.402G>A	c.(400-402)TCG>TCA	p.S134S	C7orf50_uc003sju.2_Intron|C7orf50_uc011jvt.1_Intron|C7orf50_uc011jvu.1_Intron|GPER_uc003sjz.1_Silent_p.S134S|GPER_uc003ska.1_Silent_p.S134S|GPER_uc003skb.2_Silent_p.S134S	NM_001098201	NP_001091671	Q99527	GPER_HUMAN	G protein-coupled receptor 30	134	Helical; Name=3; (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to plasma membrane	G-protein coupled receptor activity			ovary(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;2.32e-16)		CCTTCATGTCGCTCTTCCTGC	0.607		NaN											0	0	0	0.004289	0	31	118									
TNRC18	84629	broad.mit.edu	37	7	5410707	5410707	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr7:5410707G>A	uc003soi.3	-	11	3867	c.3518C>T	c.(3517-3519)CCG>CTG	p.P1173L		NM_001080495	NP_001073964	O15417	TNC18_HUMAN	trinucleotide repeat containing 18	1173	Pro-rich.						DNA binding				0		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		CTCCAGAGGCGGCAGCTCTGT	0.706		NaN											0	0	0	0.008871	0	18	62									
FAM188B	84182	broad.mit.edu	37	7	30891838	30891838	+	Silent	SNP	G	G	C			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr7:30891838G>C	uc003tbt.2	+	11	1631	c.1554G>C	c.(1552-1554)TCG>TCC	p.S518S	FAM188B_uc010kwe.2_Silent_p.S489S|AQP1_uc011kac.1_5'Flank	NM_032222	NP_115598	Q4G0A6	F188B_HUMAN	hypothetical protein LOC84182	518											0						TTAGGGCTTCGAGAACACAGC	0.463		NaN											0	0	0	0.00333	0	18	113									
BBS9	27241	broad.mit.edu	37	7	33376191	33376191	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr7:33376191G>A	uc003tdn.1	+	10	1668	c.1155G>A	c.(1153-1155)ATG>ATA	p.M385I	BBS9_uc003tdo.1_Missense_Mutation_p.M385I|BBS9_uc003tdp.1_Missense_Mutation_p.M385I|BBS9_uc003tdq.1_Missense_Mutation_p.M385I|BBS9_uc010kwn.1_RNA|BBS9_uc011kao.1_Missense_Mutation_p.M263I	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2	385					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)			ATGTAGAAATGAAAGAACTTC	0.333		NaN							Bardet-Biedl_syndrome				0	0	0	0.009096	0	4	29									
PURB	5814	broad.mit.edu	37	7	44924070	44924070	+	Missense_Mutation	SNP	C	C	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr7:44924070C>A	uc003tme.2	-	1	891	c.878G>T	c.(877-879)CGA>CTA	p.R293L		NM_033224	NP_150093	Q96QR8	PURB_HUMAN	purine-rich element binding protein B	293					regulation of myeloid cell differentiation	DNA replication factor A complex	mRNA binding|single-stranded DNA binding|transcription factor binding				0						CCCACCACGTCGCTCATAAAG	0.587		NaN											1	0	2.29192e-23	0.01441	2.46822e-23	41	148									
FZD1	8321	broad.mit.edu	37	7	90896136	90896136	+	Silent	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr7:90896136C>T	uc003ula.2	+	1	2354	c.1941C>T	c.(1939-1941)GTC>GTT	p.V647V		NM_003505	NP_003496	Q9UP38	FZD1_HUMAN	frizzled 1 precursor	647	PDZ-binding.|Cytoplasmic (Potential).				autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding				0	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			AGACTACAGTCTGAGACCCGG	0.627		NaN											0	0	0	0.004289	0	32	89									
ACHE	43	broad.mit.edu	37	7	100490233	100490233	+	Silent	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr7:100490233C>T	uc003uxd.2	-	2	1431	c.1275G>A	c.(1273-1275)CTG>CTA	p.L425L	UFSP1_uc003uxc.3_5'Flank|ACHE_uc003uxe.2_Silent_p.L425L|ACHE_uc003uxf.2_Silent_p.L425L|ACHE_uc003uxg.2_Silent_p.L425L|ACHE_uc003uxh.2_Intron|ACHE_uc003uxi.2_Silent_p.L425L	NM_000665	NP_000656	P22303	ACES_HUMAN	acetylcholinesterase isoform E4-E6 precursor	425					acetylcholine catabolic process in synaptic cleft|amyloid precursor protein metabolic process|cell adhesion|cell proliferation|choline metabolic process|DNA replication|muscle organ development|neurotransmitter biosynthetic process|osteoblast development|positive regulation of protein secretion|regulation of axonogenesis|regulation of dendrite morphogenesis|response to wounding|synapse assembly	anchored to membrane|axon|basal lamina|cell junction|cell surface|dendrite|endoplasmic reticulum lumen|extracellular space|Golgi apparatus|neuromuscular junction|nucleus|perinuclear region of cytoplasm|postsynaptic membrane|presynaptic membrane|synaptic cleft	acetylcholine binding|acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|collagen binding|laminin-1 binding|protein homodimerization activity|serine hydrolase activity			skin(2)	2	Lung NSC(181;0.041)|all_lung(186;0.0581)				Ambenonium(DB01122)|Atropine(DB00572)|Choline(DB00122)|Decamethonium(DB01245)|Demecarium bromide(DB00944)|Donepezil(DB00843)|Edrophonium(DB01010)|Ephedrine(DB01364)|Galantamine(DB00674)|Gallamine Triethiodide(DB00483)|Isoflurophate(DB00677)|Neostigmine(DB01400)|Physostigmine(DB00981)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Tacrine(DB00382)|Tubocurarine(DB01199)	GGGCCTCCCTCAGGCGTGCCG	0.697		NaN											0	0	0	0.006214	0	8	33									
ACHE	43	broad.mit.edu	37	7	100491541	100491541	+	Missense_Mutation	SNP	C	C	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr7:100491541C>A	uc003uxd.2	-	1	469	c.313G>T	c.(313-315)GAC>TAC	p.D105Y	ACHE_uc003uxe.2_Missense_Mutation_p.D105Y|ACHE_uc003uxf.2_Missense_Mutation_p.D105Y|ACHE_uc003uxg.2_Missense_Mutation_p.D105Y|ACHE_uc003uxh.2_Missense_Mutation_p.D105Y|ACHE_uc003uxi.2_Missense_Mutation_p.D105Y|ACHE_uc003uxj.1_Missense_Mutation_p.D224Y	NM_000665	NP_000656	P22303	ACES_HUMAN	acetylcholinesterase isoform E4-E6 precursor	105					acetylcholine catabolic process in synaptic cleft|amyloid precursor protein metabolic process|cell adhesion|cell proliferation|choline metabolic process|DNA replication|muscle organ development|neurotransmitter biosynthetic process|osteoblast development|positive regulation of protein secretion|regulation of axonogenesis|regulation of dendrite morphogenesis|response to wounding|synapse assembly	anchored to membrane|axon|basal lamina|cell junction|cell surface|dendrite|endoplasmic reticulum lumen|extracellular space|Golgi apparatus|neuromuscular junction|nucleus|perinuclear region of cytoplasm|postsynaptic membrane|presynaptic membrane|synaptic cleft	acetylcholine binding|acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|collagen binding|laminin-1 binding|protein homodimerization activity|serine hydrolase activity			skin(2)	2	Lung NSC(181;0.041)|all_lung(186;0.0581)				Ambenonium(DB01122)|Atropine(DB00572)|Choline(DB00122)|Decamethonium(DB01245)|Demecarium bromide(DB00944)|Donepezil(DB00843)|Edrophonium(DB01010)|Ephedrine(DB01364)|Galantamine(DB00674)|Gallamine Triethiodide(DB00483)|Isoflurophate(DB00677)|Neostigmine(DB01400)|Physostigmine(DB00981)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Tacrine(DB00382)|Tubocurarine(DB01199)	TATAGGGTGTCCACATATTGG	0.592		NaN											1	0	1.81118e-26	0.01441	1.95937e-26	45	167									
ATP6V1H	51606	broad.mit.edu	37	8	54708314	54708314	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr8:54708314G>C	uc003xrl.2	-	9	915	c.763C>G	c.(763-765)CAA>GAA	p.Q255E	ATP6V1H_uc003xrk.2_Missense_Mutation_p.Q215E|ATP6V1H_uc003xrm.2_Missense_Mutation_p.Q255E|ATP6V1H_uc003xrn.2_Missense_Mutation_p.Q237E|ATP6V1H_uc011ldv.1_Missense_Mutation_p.Q175E|ATP6V1H_uc010lyd.2_Missense_Mutation_p.Q191E	NM_213620	NP_998785	Q9UI12	VATH_HUMAN	ATPase, H+ transporting, lysosomal 50/57kDa, V1	255					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|endocytosis|insulin receptor signaling pathway|interspecies interaction between organisms|regulation of defense response to virus by virus|transferrin transport|vacuolar acidification|viral reproduction	cytosol|plasma membrane|vacuolar proton-transporting V-type ATPase, V1 domain	enzyme regulator activity|protein binding|proton-transporting ATPase activity, rotational mechanism				0		all_epithelial(80;0.0487)|Lung NSC(129;0.109)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;2.79e-06)|Epithelial(17;0.000629)|all cancers(17;0.00359)			TCACACATTTGAGGACTGAAT	0.403		NaN											0	0	0	0.01441	0	62	81									
TRPA1	8989	broad.mit.edu	37	8	72981353	72981353	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr8:72981353G>A	uc003xza.2	-	3	524	c.349C>T	c.(349-351)CTT>TTT	p.L117F		NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	117	Cytoplasmic (Potential).|ANK 2.					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	CTGCTGAGAAGAAACTTAACG	0.413		NaN											0	0	0	0.009718	0	44	187									
KIAA1429	25962	broad.mit.edu	37	8	95523769	95523769	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr8:95523769G>A	uc003ygo.1	-	13	3047	c.3034C>T	c.(3034-3036)CTT>TTT	p.L1012F	KIAA1429_uc003ygp.2_Missense_Mutation_p.L1012F|KIAA1429_uc010maz.1_RNA	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	1012					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			GTTTTAAGAAGAGTGAGTGTG	0.448		NaN											0	0	0	0.007413	0	18	209									
PABPC1	26986	broad.mit.edu	37	8	101719200	101719200	+	Silent	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr8:101719200G>A	uc003yjs.1	-	10	1866	c.1362C>T	c.(1360-1362)ATC>ATT	p.I454I	PABPC1_uc011lhc.1_Silent_p.I422I|PABPC1_uc011lhd.1_Silent_p.I409I|PABPC1_uc003yjt.1_Silent_p.I451I|PABPC1_uc003yju.2_Intron	NM_002568	NP_002559	P11940	PABP1_HUMAN	poly(A) binding protein, cytoplasmic 1	454					mRNA polyadenylation|mRNA stabilization|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|translation	catalytic step 2 spliceosome|cytosol	nucleotide binding|poly(A) RNA binding|protein C-terminus binding|translation activator activity				0	all_cancers(14;6.8e-05)|all_epithelial(15;3.16e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;6.37e-11)|all cancers(13;1.11e-08)|OV - Ovarian serous cystadenocarcinoma(57;3.91e-05)|STAD - Stomach adenocarcinoma(118;0.206)			CAGCTGGGCGGATAGCACCGG	0.433		NaN											0	0	0	0.010504	0	20	120									
TRPS1	7227	broad.mit.edu	37	8	116616194	116616194	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr8:116616194C>G	uc003ynz.2	-	3	2422	c.1963G>C	c.(1963-1965)GAT>CAT	p.D655H	TRPS1_uc011lhy.1_Missense_Mutation_p.D659H|TRPS1_uc003yny.2_Missense_Mutation_p.D668H|TRPS1_uc010mcy.2_Missense_Mutation_p.D655H	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	655	Mediates interaction with GLI3.				negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			TGCTGCCCATCCGATCCTTGC	0.463		NaN							Langer-Giedion_syndrome				0	0	0	0.003163	0	15	94									
TG	7038	broad.mit.edu	37	8	133913623	133913623	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr8:133913623G>C	uc003ytw.2	+	16	3500	c.3459G>C	c.(3457-3459)AAG>AAC	p.K1153N	TG_uc010mdw.2_Intron	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	1153	Thyroglobulin type-1 10.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		ATGTGCTCAAGAGTGGAGTCC	0.607		NaN											0	0	0	0.01441	0	66	136									
KIFC2	90990	broad.mit.edu	37	8	145697780	145697780	+	Silent	SNP	C	C	G			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr8:145697780C>G	uc003zcz.2	+	15	1709	c.1644C>G	c.(1642-1644)GCC>GCG	p.A548A	KIFC2_uc003zda.2_5'Flank	NM_145754	NP_665697	Q96AC6	KIFC2_HUMAN	kinesin family member C2	548	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			ovary(2)|central_nervous_system(1)	3	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			AGCGCCTGGCCGTGAGGCAGG	0.657		NaN											0	0	0	0.001168	0	5	23									
GPT	2875	broad.mit.edu	37	8	145732224	145732224	+	Silent	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr8:145732224C>T	uc011lli.1	+	11	1555	c.1398C>T	c.(1396-1398)TTC>TTT	p.F466F	GPT_uc003zdh.3_Silent_p.F466F|MFSD3_uc003zdi.1_5'Flank	NM_005309	NP_005300	P24298	ALAT1_HUMAN	glutamic pyruvate transaminase	466					gluconeogenesis	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-alanine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			ovary(1)|central_nervous_system(1)	2	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)		L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	CCTACCACTTCCGGTGAGGCC	0.637		NaN											0	0	0	0.010771	0	40	9									
ACO1	48	broad.mit.edu	37	9	32450097	32450097	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr9:32450097G>C	uc003zqw.3	+	21	2813	c.2658G>C	c.(2656-2658)AAG>AAC	p.K886N	ACO1_uc003zqx.3_Missense_Mutation_p.K886N|ACO1_uc003zqy.3_RNA	NM_002197	NP_002188	P21399	ACOC_HUMAN	aconitase 1	886					citrate metabolic process|response to iron(II) ion|tricarboxylic acid cycle	cytosol|endoplasmic reticulum|Golgi apparatus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron-responsive element binding|isocitrate hydro-lyase (cis-aconitate-forming) activity|metal ion binding|protein binding				0			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;3.94e-06)		TGATCCGCAAGATGGCCAAGT	0.592		NaN											0	0	0	0.014323	0	21	42									
UBAP2	55833	broad.mit.edu	37	9	33943441	33943441	+	Silent	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr9:33943441G>A	uc003ztq.1	-	15	1805	c.1692C>T	c.(1690-1692)ATC>ATT	p.I564I	UBAP2_uc011loc.1_Silent_p.I473I|UBAP2_uc011lod.1_Silent_p.I297I|UBAP2_uc011loe.1_Silent_p.I319I|UBAP2_uc011lof.1_Silent_p.I489I|UBAP2_uc011log.1_Silent_p.I510I|UBAP2_uc003ztr.2_Silent_p.I436I|UBAP2_uc003zts.2_Silent_p.I197I	NM_018449	NP_060919	Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2	564										ovary(3)	3			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		AATACAAGCTGATGGGAATCT	0.393		NaN											0	0	0	0.008361	0	27	60									
UBAP2	55833	broad.mit.edu	37	9	34017107	34017107	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr9:34017107G>A	uc003ztq.1	-	2	153	c.40C>T	c.(40-42)CGG>TGG	p.R14W	UBAP2_uc011loc.1_5'UTR|UBAP2_uc011lod.1_Intron|UBAP2_uc011loe.1_5'UTR|UBAP2_uc011lof.1_5'UTR|UBAP2_uc011log.1_Missense_Mutation_p.R13W|UBAP2_uc003ztr.2_5'UTR	NM_018449	NP_060919	Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2	14										ovary(3)	3			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		GGTTTTTCCCGAGCACCTCGA	0.353		NaN											0	0	0	0.006122	0	15	80									
DNAJB5	25822	broad.mit.edu	37	9	34996695	34996695	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr9:34996695C>G	uc003zvt.2	+	3	783	c.645C>G	c.(643-645)ATC>ATG	p.I215M	DNAJB5_uc003zvs.2_Missense_Mutation_p.I249M|DNAJB5_uc011los.1_Missense_Mutation_p.I287M	NM_012266	NP_036398	O75953	DNJB5_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 5	215					protein folding|response to unfolded protein		heat shock protein binding|unfolded protein binding				0			LUSC - Lung squamous cell carcinoma(32;0.00575)			ACATAGTCATCAAGCGTGGCT	0.552		NaN											0	0	0	0.013537	0	11	34									
FAM75A6	389730	broad.mit.edu	37	9	43624988	43624988	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr9:43624988C>G	uc011lrb.1	-	4	3728	c.3699G>C	c.(3697-3699)CAG>CAC	p.Q1233H		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	1233						integral to membrane					0						CTTGAAACTTCTGTTTGTGCT	0.502		NaN											0	0	0	0.01441	0	86	507									
APBA1	320	broad.mit.edu	37	9	72131394	72131394	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr9:72131394C>T	uc004ahh.2	-	2	1009	c.733G>A	c.(733-735)GAG>AAG	p.E245K		NM_001163	NP_001154	Q02410	APBA1_HUMAN	amyloid beta A4 precursor protein-binding,	245	Munc-18-1 binding.				axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				lung(1)	1						CTGTCGGACTCGCCGTCGGAG	0.701		NaN											0	0	0	0.012319	0	16	27									
FAM120A	23196	broad.mit.edu	37	9	96214620	96214620	+	Silent	SNP	C	C	G			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr9:96214620C>G	uc004atw.2	+	1	448	c.423C>G	c.(421-423)CCC>CCG	p.P141P	FAM120AOS_uc004atm.2_5'Flank|FAM120AOS_uc004atn.3_5'Flank|FAM120AOS_uc004ato.3_5'Flank|FAM120AOS_uc004atp.3_5'Flank|FAM120AOS_uc004atq.3_5'Flank|FAM120AOS_uc004atr.3_5'Flank|FAM120AOS_uc004ats.3_Intron|FAM120AOS_uc004att.3_Intron|FAM120AOS_uc004atu.3_Silent_p.T124T|FAM120A_uc004atv.2_Silent_p.P141P	NM_014612	NP_055427	Q9NZB2	F120A_HUMAN	oxidative stress-associated Src activator	141						cytoplasm|plasma membrane	RNA binding				0						TCCTGCCGCCCGTCTGCATGG	0.567		NaN											0	0	0	0.00308	0	6	41									
FPGS	2356	broad.mit.edu	37	9	130570856	130570856	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr9:130570856C>T	uc004bsg.1	+	10	892	c.842C>T	c.(841-843)CCG>CTG	p.P281L	FPGS_uc004bsh.1_Missense_Mutation_p.P98L|FPGS_uc011mal.1_Missense_Mutation_p.P255L|FPGS_uc004bsi.1_Missense_Mutation_p.P231L	NM_004957	NP_004948	Q05932	FOLC_HUMAN	folylpolyglutamate synthase isoform a precursor	281					folic acid metabolic process|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|one-carbon metabolic process	cytosol|mitochondrial matrix	ATP binding|tetrahydrofolylpolyglutamate synthase activity				0					L-Glutamic Acid(DB00142)	TACCTGTGTCCGATGCTGGAG	0.692		NaN											0	0	0	0.013537	0	9	20									
TOR1A	1861	broad.mit.edu	37	9	132584943	132584943	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr9:132584943C>T	uc004byl.2	-	2	438	c.361G>A	c.(361-363)GAG>AAG	p.E121K	TOR1A_uc004bym.2_RNA|TOR1A_uc004byn.2_Missense_Mutation_p.E121K	NM_000113	NP_000104	O14656	TOR1A_HUMAN	torsin A precursor	121					chaperone mediated protein folding requiring cofactor|response to unfolded protein	endoplasmic reticulum lumen|nuclear membrane	ATP binding|serine-type endopeptidase activity|unfolded protein binding			central_nervous_system(1)	1		Ovarian(14;0.00556)				AGACCACCCTCGTAAATATTC	0.488		NaN											0	0	0	0.005524	0	39	150									
VAV2	7410	broad.mit.edu	37	9	136634579	136634579	+	Silent	SNP	G	G	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr9:136634579G>A	uc004ces.2	-	28	2440	c.2394C>T	c.(2392-2394)CTC>CTT	p.L798L	VAV2_uc004cer.2_Intron	NM_001134398	NP_001127870	P52735	VAV2_HUMAN	vav 2 guanine nucleotide exchange factor isoform	798					angiogenesis|apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	metal ion binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(3)|ovary(2)|lung(2)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(145;3.9e-07)|Epithelial(140;2.07e-06)|all cancers(34;9.39e-06)		AAGCAAAGCTGAGGCCCTGAG	0.632		NaN											0	0	0	0.000602	0	5	24									
GATA1	2623	broad.mit.edu	37	X	48650333	48650333	+	Silent	SNP	G	G	A	rs145355350		TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chrX:48650333G>A	uc004dkq.3	+	3	394	c.303G>A	c.(301-303)ACG>ACA	p.T101T		NM_002049	NP_002040	P15976	GATA1_HUMAN	GATA binding protein 1	101					basophil differentiation|eosinophil differentiation|erythrocyte development|megakaryocyte differentiation|platelet aggregation|platelet formation|positive regulation of anti-apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|regulation of glycoprotein biosynthetic process|transcription from RNA polymerase II promoter	nuclear membrane|nucleolus|nucleoplasm	C2H2 zinc finger domain binding|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.?(2)|p.V74_C199del(1)|p.V77_A120>A(1)		haematopoietic_and_lymphoid_tissue(246)|lung(2)	248						ACGGCAAGACGGGGCTCTACC	0.612		NaN	Mis|F		megakaryoblastic leukemia of Downs Syndrome								0	0	0	0.004878	0	38	4									
AWAT2	158835	broad.mit.edu	37	X	69262998	69262998	+	Missense_Mutation	SNP	A	A	T			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chrX:69262998A>T	uc004dxt.1	-	5	574	c.568T>A	c.(568-570)TGC>AGC	p.C190S		NM_001002254	NP_001002254	Q6E213	AWAT2_HUMAN	wax synthase 2	190						endoplasmic reticulum membrane|integral to membrane	long-chain-alcohol O-fatty-acyltransferase activity				0						CTGTATCTGCACTCAGCCAGT	0.547		NaN											0	0	0	0.009096	0	3	6									
NXF5	55998	broad.mit.edu	37	X	101095527	101095527	+	Silent	SNP	T	T	C			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chrX:101095527T>C	uc011mrk.1	-	10	1002	c.642A>G	c.(640-642)CTA>CTG	p.L214L	NXF5_uc004eih.1_RNA|NXF5_uc004eii.1_RNA|NXF5_uc004eij.1_RNA|NXF5_uc004eik.1_RNA|NXF5_uc004eil.1_RNA	NM_032946	NP_116564	Q9H1B4	NXF5_HUMAN	nuclear RNA export factor 5	214	LRR 3.				mRNA export from nucleus|multicellular organismal development	actin cytoskeleton|cytoplasm|nucleus	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			central_nervous_system(1)	1						CTTCTAGCCATAGCTCTTCGA	0.577		NaN											0	0	0	0.010504	0	14	70									
WDR44	54521	broad.mit.edu	37	X	117578414	117578414	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chrX:117578414C>G	uc004eqn.2	+	19	3029	c.2604C>G	c.(2602-2604)AAC>AAG	p.N868K	WDR44_uc004eqo.2_Missense_Mutation_p.N860K|WDR44_uc011mtr.1_Missense_Mutation_p.N779K|WDR44_uc010nqi.2_Missense_Mutation_p.N578K	NM_019045	NP_061918	Q5JSH3	WDR44_HUMAN	WD repeat domain 44 protein	868						cytosol|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm				lung(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5						CAGAAGGGAACGAGAAAAGTG	0.388		NaN											0	0	0	0.011902	0	44	52									
SV2A	9900	broad.mit.edu	37	1	149885018	149885019	+	Frame_Shift_Ins	INS	-	-	C			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:149885018_149885019insC	uc001etg.2	-	2	865_866	c.374_375insG	c.(373-375)GGCfs	p.G125fs	SV2A_uc001eth.2_Frame_Shift_Ins_p.G125fs	NM_014849	NP_055664	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2	125	Cytoplasmic (Potential).				neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(6)|pancreas(1)	7	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	CATCACTCAAGCCCCCCCTTAC	0.629		NaN											NaN	NaN	NaN	NaN	NaN	7	843	---	---							
MCL1	4170	broad.mit.edu	37	1	150551492	150551494	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:150551492_150551494delTCC	uc001euz.2	-	1	643_645	c.513_515delGGA	c.(511-516)GAGGAC>GAC	p.E171del	MCL1_uc010pch.1_In_Frame_Del_p.E61del|MCL1_uc001eva.2_In_Frame_Del_p.E171del	NM_021960	NP_068779	Q07820	MCL1_HUMAN	myeloid cell leukemia sequence 1 isoform 1	171	PEST-like.				anti-apoptosis|apoptosis|cell fate determination|cellular homeostasis|multicellular organismal development|response to cytokine stimulus	integral to membrane|mitochondrial outer membrane|nucleoplasm	BH3 domain binding|protein binding|protein channel activity|protein heterodimerization activity				0	all_cancers(9;1.69e-53)|all_epithelial(9;1.95e-43)|all_lung(15;1.09e-34)|Lung NSC(24;4.04e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			GTACAACTCGTCCTCCTCCTCCT	0.635		NaN											NaN	NaN	NaN	NaN	NaN	9	397	---	---							
LRP4	4038	broad.mit.edu	37	11	46916236	46916243	+	Frame_Shift_Del	DEL	CAAGCTCG	CAAGCTCG	-	rs141108617		TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr11:46916236_46916243delCAAGCTCG	uc001ndn.3	-	12	1583_1590	c.1437_1444delCGAGCTTG	c.(1435-1446)CGCGAGCTTGTCfs	p.R479fs		NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	479_482	Extracellular (Potential).|LDL-receptor class B 1.				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		GACCAGAAGACAAGCTCGCGGCGGTGGT	0.587		NaN											NaN	NaN	NaN	NaN	NaN	11	51	---	---							
OR8D4	338662	broad.mit.edu	37	11	123777441	123777442	+	Frame_Shift_Ins	INS	-	-	T	rs79561639	byFrequency	TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr11:123777441_123777442insT	uc010saa.1	+	1	303_304	c.303_304insT	c.(301-306)CTGTTTfs	p.L101fs		NM_001005197	NP_001005197	Q8NGM9	OR8D4_HUMAN	olfactory receptor, family 8, subfamily D,	101_102	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.93e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0409)		TGATTCAGCTGTTTTTTTTCTG	0.436		NaN											NaN	NaN	NaN	NaN	NaN	8	274	---	---							
EIF2AK4	440275	broad.mit.edu	37	15	40282508	40282508	+	Frame_Shift_Del	DEL	T	T	-			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr15:40282508delT	uc001zkm.1	+	16	2611	c.2561delT	c.(2560-2562)ATTfs	p.I854fs	EIF2AK4_uc010bbj.1_Frame_Shift_Del_p.I555fs|EIF2AK4_uc001zkn.1_5'Flank	NM_001013703	NP_001013725	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha	854	Protein kinase 2.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			lung(2)|stomach(1)|skin(1)	4		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		CCTGTCAACATTTTTTTGGAT	0.358		NaN											NaN	NaN	NaN	NaN	NaN	8	302	---	---							
TP53	7157	broad.mit.edu	37	17	7579413	7579414	+	Frame_Shift_Ins	INS	-	-	C			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08			-	C	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr17:7579413_7579414insC	uc002gim.2	-	4	467_468	c.273_274insG	c.(271-276)TGGCCCfs	p.W91fs	TP53_uc002gig.1_Frame_Shift_Ins_p.W91fs|TP53_uc002gih.2_Frame_Shift_Ins_p.W91fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Frame_Shift_Ins_p.W91fs|TP53_uc010cni.1_Frame_Shift_Ins_p.W91fs|TP53_uc002gij.2_Frame_Shift_Ins_p.W91fs|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Frame_Shift_Ins_p.W52fs|TP53_uc010cnk.1_Frame_Shift_Ins_p.W106fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	91_92	Interaction with WWOX.		P -> S (in a sporadic cancer; somatic mutation).|P -> A (in a sporadic cancer; somatic mutation).|P -> L (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.W91*(11)|p.0?(7)|p.G59fs*23(3)|p.V73fs*9(1)|p.D48fs*55(1)|p.L93fs*30(1)|p.P92fs*57(1)|p.W91fs*57(1)|p.A88fs*52(1)|p.P92A(1)|p.W91fs*13(1)|p.P87fs*54(1)|p.P13fs*18(1)|p.S33fs*23(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGACAGGGGCCAGGAGGGGG	0.629		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			NaN	NaN	NaN	NaN	NaN	97	16	---	---							
WDR33	55339	broad.mit.edu	37	2	128471200	128471200	+	Frame_Shift_Del	DEL	G	G	-			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr2:128471200delG	uc002tpg.1	-	18	3448	c.3265delC	c.(3265-3267)CGGfs	p.R1089fs		NM_018383	NP_060853	Q9C0J8	WDR33_HUMAN	WD repeat domain 33 isoform 1	1089					postreplication repair|spermatogenesis	collagen|nucleus	protein binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		TCGGGATCCCGGGGGAAACGT	0.617		NaN											NaN	NaN	NaN	NaN	NaN	7	607	---	---							
EP300	2033	broad.mit.edu	37	22	41572411	41572411	+	Frame_Shift_Del	DEL	C	C	-			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08			C	-	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr22:41572411delC	uc003azl.3	+	30	5335	c.4940delC	c.(4939-4941)GCCfs	p.A1647fs		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1647	Binding region for E1A adenovirus.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						CTCCGAAGAGCCCAGTGGTCC	0.572		NaN	T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				NaN	NaN	NaN	NaN	NaN	27	68	---	---							
H1FOO	132243	broad.mit.edu	37	3	129268107	129268108	+	Frame_Shift_Ins	INS	-	-	A	rs150160917	by1000genomes	TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr3:129268107_129268108insA	uc003emu.2	+	3	647_648	c.642_643insA	c.(640-645)GCTAGGfs	p.A214fs	H1FOO_uc003emv.2_Frame_Shift_Ins_p.A75fs	NM_153833	NP_722575	Q8IZA3	H1FOO_HUMAN	H1 histone family, member O, oocyte-specific	214_215					meiosis|nucleosome assembly	cytoplasm|nucleosome	DNA binding			skin(1)	1						CGGGAGAGGCTAGGAAGGTGCC	0.653		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---	---							
SLC25A4	291	broad.mit.edu	37	4	186067010	186067011	+	Frame_Shift_Ins	INS	-	-	A			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr4:186067010_186067011insA	uc003ixd.2	+	3	825_826	c.696_697insA	c.(694-699)GACACTfs	p.D232fs	SLC25A4_uc003ixe.2_RNA	NM_001151	NP_001142	P12235	ADT1_HUMAN	adenine nucleotide translocator 1	232_233	Helical; Name=5; (By similarity).|Solcar 3.				energy reserve metabolic process|interspecies interaction between organisms|mitochondrial genome maintenance|negative regulation of necrotic cell death|regulation of insulin secretion|viral reproduction	integral to plasma membrane|mitochondrial inner membrane	adenine transmembrane transporter activity|protein binding			ovary(1)	1		all_lung(41;1.19e-13)|Lung NSC(41;3.16e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00872)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;4.48e-44)|Epithelial(43;2.1e-41)|all cancers(43;1.37e-36)|Colorectal(24;4.79e-05)|BRCA - Breast invasive adenocarcinoma(30;7.72e-05)|GBM - Glioblastoma multiforme(59;0.000274)|COAD - Colon adenocarcinoma(29;0.000362)|STAD - Stomach adenocarcinoma(60;0.000756)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.155)	Adenosine triphosphate(DB00171)|Clodronate(DB00720)	ACCCCTTTGACACTGTTCGTCG	0.52		NaN											NaN	NaN	NaN	NaN	NaN	30	12	---	---							
FOXQ1	94234	broad.mit.edu	37	6	1313374	1313376	+	In_Frame_Del	DEL	CAA	CAA	-			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08			CAA	-	CAA	CAA		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr6:1313374_1313376delCAA	uc003mtl.3	+	1	700_702	c.435_437delCAA	c.(433-438)ATCAAC>ATC	p.N146del		NM_033260	NP_150285	Q9C009	FOXQ1_HUMAN	forkhead box Q1	146	Fork-head.				DNA fragmentation involved in apoptotic nuclear change|embryo development|hair follicle morphogenesis|pattern specification process|positive regulation of caspase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	caspase regulator activity|DNA bending activity|double-stranded DNA binding|estrogen receptor binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin conjugating enzyme binding				0	Ovarian(93;0.0733)	Breast(5;0.052)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.0954)|BRCA - Breast invasive adenocarcinoma(62;0.18)		TGGCGGAGATCAACGAGTACCTC	0.64		NaN											NaN	NaN	NaN	NaN	NaN	22	88	---	---							
SLC17A2	10246	broad.mit.edu	37	6	25921520	25921520	+	Frame_Shift_Del	DEL	T	T	-			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr6:25921520delT	uc011dkb.1	-	3	444	c.361delA	c.(361-363)ATGfs	p.M121fs	SLC17A2_uc011dkc.1_Frame_Shift_Del_p.M121fs|SLC17A2_uc003nfl.2_Frame_Shift_Del_p.M121fs			O00624	NPT3_HUMAN	SubName: Full=Solute carrier family 17 (Sodium phosphate), member 2, isoform CRA_b; SubName: Full=Putative uncharacterized protein SLC17A2;	121					phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			ovary(1)	1						GCACCAAGCATTTTTTTTGCT	0.453		NaN											NaN	NaN	NaN	NaN	NaN	7	236	---	---							
C6orf174	387104	broad.mit.edu	37	6	127804080	127804080	+	Frame_Shift_Del	DEL	T	T	-			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr6:127804080delT	uc003qbd.2	-	5	2400	c.1535delA	c.(1534-1536)AAGfs	p.K512fs		NM_001012279	NP_001012279	Q5TF21	CF174_HUMAN	hypothetical protein LOC387104 precursor	512	Potential.					integral to membrane				breast(3)|ovary(2)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.161)		CTGTTGAGCCTTTTTTTCAGA	0.294		NaN											NaN	NaN	NaN	NaN	NaN	13	925	---	---