Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
NOC2L	26155	broad.mit.edu	37	1	892328	892328	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:892328C>G	uc001abz.3	-	4	491	c.432G>C	c.(430-432)AAG>AAC	p.K144N	NOC2L_uc001aby.3_5'UTR|NOC2L_uc009vjq.2_Missense_Mutation_p.K144N	NM_015658	NP_056473	Q9Y3T9	NOC2L_HUMAN	nucleolar complex associated 2 homolog	144						nucleolus	protein binding			ovary(1)|skin(1)	2	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.86e-38)|OV - Ovarian serous cystadenocarcinoma(86;6.08e-23)|Colorectal(212;0.000161)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(365;0.000475)|Kidney(185;0.00231)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0344)|Lung(427;0.2)		GAACAGAATTCTTCTTCCCCT	0.592		NaN											0	0	0	0.01441	0	72	124									
PLEKHN1	84069	broad.mit.edu	37	1	906303	906303	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:906303G>C	uc001ace.2	+	5	684	c.649G>C	c.(649-651)GAG>CAG	p.E217Q	PLEKHN1_uc001acd.2_Missense_Mutation_p.E177Q|PLEKHN1_uc001acf.2_Missense_Mutation_p.E177Q	NM_032129	NP_115505	Q494U1	PKHN1_HUMAN	pleckstrin homology domain containing, family N	217	PH 1.										0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.93e-23)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.00095)|Kidney(185;0.0023)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.199)		CAGCCGGGCCGAGCTGGACCG	0.726		NaN											0	0	0	0.006122	0	17	11									
TTLL10	254173	broad.mit.edu	37	1	1117193	1117193	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:1117193G>T	uc001acy.2	+	9	979	c.828G>T	c.(826-828)CAG>CAT	p.Q276H	uc001acx.1_5'Flank|TTLL10_uc010nyg.1_Missense_Mutation_p.Q276H|TTLL10_uc001acz.1_Missense_Mutation_p.Q203H	NM_001130045	NP_001123517	Q6ZVT0	TTL10_HUMAN	tubulin tyrosine ligase-like family, member 10	276	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			large_intestine(1)	1	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;4.75e-36)|OV - Ovarian serous cystadenocarcinoma(86;5.82e-22)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		TCAGGCCACAGAGGTAGACTC	0.637		NaN											1	0	2.52707e-12	0.006214	2.69921e-12	10	13									
CELA2B	51032	broad.mit.edu	37	1	15809801	15809801	+	Silent	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:15809801C>T	uc001awl.2	+	5	424	c.399C>T	c.(397-399)CTC>CTT	p.L133L		NM_015849	NP_056933	P08218	CEL2B_HUMAN	elastase 2B preproprotein	133	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)	1						CCGTCTCCCTCACCGACAAGA	0.602		NaN											0	0	0	0.004878	0	32	42									
CASP9	842	broad.mit.edu	37	1	15821948	15821948	+	Splice_Site	SNP	C	C	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:15821948C>G	uc001awn.2	-	7	964	c.869_splice	c.e7-1	p.E290_splice	CASP9_uc001awm.1_Splice_Site_p.E290_splice|CASP9_uc001awo.2_Splice_Site_p.E140_splice|CASP9_uc001awp.2_Splice_Site_p.E134_splice|CASP9_uc009voi.2_Splice_Site_p.E134_splice|CASP9_uc010obm.1_Splice_Site_p.E207_splice|CASP9_uc001awq.2_Splice_Site_p.E207_splice	NM_001229	NP_001220	P55211	CASP9_HUMAN	caspase 9 isoform alpha preproprotein						activation of caspase activity by cytochrome c|induction of apoptosis by intracellular signals|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol	cysteine-type endopeptidase activity|enzyme activator activity|protein binding			central_nervous_system(1)|kidney(1)	2		Breast(348;0.000207)|all_lung(284;0.000211)|Colorectal(325;0.000259)|Lung NSC(340;0.000269)|Renal(390;0.000518)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;8.49e-07)|COAD - Colon adenocarcinoma(227;4.36e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00013)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00763)|READ - Rectum adenocarcinoma(331;0.0655)		TCTTTCTGCTCTGCAGGAAGC	0.388		NaN											0	0	0	0.001168	0	5	14									
SPEN	23013	broad.mit.edu	37	1	16258553	16258553	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:16258553G>A	uc001axk.1	+	11	6022	c.5818G>A	c.(5818-5820)GAG>AAG	p.E1940K	SPEN_uc010obp.1_Missense_Mutation_p.E1899K	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	1940	Potential.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		AGAGCTTCAGGAGGCTGCAGC	0.587		NaN											0	0	0	0.010504	0	18	73									
NBPF1	55672	broad.mit.edu	37	1	16891403	16891403	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:16891403C>G	uc009vos.1	-	29	4188	c.3300G>C	c.(3298-3300)AAG>AAC	p.K1100N	uc001ayw.2_5'Flank	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	1100	NBPF 7.					cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		ccttccccttcttTTCAATTT	0.259		NaN											0	0	0	0.00245	0	5	600									
EIF4G3	8672	broad.mit.edu	37	1	21268770	21268770	+	Silent	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:21268770G>A	uc001bec.2	-	9	965	c.709C>T	c.(709-711)CTA>TTA	p.L237L	EIF4G3_uc010odi.1_5'UTR|EIF4G3_uc010odj.1_Silent_p.L236L|EIF4G3_uc009vpz.2_Intron|EIF4G3_uc001bed.2_Silent_p.L237L|EIF4G3_uc001bef.2_Silent_p.L236L|EIF4G3_uc001bee.2_Silent_p.L243L|EIF4G3_uc001beg.2_Silent_p.L236L|EIF4G3_uc010odk.1_Silent_p.L237L|EIF4G3_uc001beh.2_Silent_p.L248L	NM_003760	NP_003751	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4	237					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		CTGAGGACTAGCCTAAGGACT	0.438		NaN											0	0	0	0.00632	0	27	108									
HSPG2	3339	broad.mit.edu	37	1	22178283	22178283	+	Splice_Site	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:22178283C>T	uc001bfj.2	-	54	7046	c.7006_splice	c.e54+1	p.P2336_splice	HSPG2_uc009vqd.2_Splice_Site_p.P2337_splice	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor						angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GCCCCACTCACGGTAGGCTAA	0.637		NaN											0	0	0	0.003755	0	33	39									
C1QB	713	broad.mit.edu	37	1	22987517	22987517	+	Silent	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:22987517C>T	uc001bgd.2	+	3	532	c.400C>T	c.(400-402)CTG>TTG	p.L134L		NM_000491	NP_000482	P02746	C1QB_HUMAN	complement component 1, q subcomponent, B chain	134	C1q.				complement activation, classical pathway|innate immune response	collagen|complement component C1 complex				breast(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.06e-27)|Colorectal(126;1.58e-07)|GBM - Glioblastoma multiforme(114;6.72e-06)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000551)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	CAACGTCCCCCTGCGCCGGGA	0.602		NaN											0	0	0	0.014323	0	23	84									
YTHDF2	51441	broad.mit.edu	37	1	29069930	29069930	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:29069930C>T	uc001brc.2	+	4	1645	c.1148C>T	c.(1147-1149)TCA>TTA	p.S383L	YTHDF2_uc001brd.2_Missense_Mutation_p.S380L|YTHDF2_uc010ofx.1_Missense_Mutation_p.S333L|YTHDF2_uc001bre.2_Missense_Mutation_p.S333L	NM_016258	NP_057342	Q9Y5A9	YTHD2_HUMAN	high glucose-regulated protein 8	383					humoral immune response					ovary(1)|skin(1)	2		Colorectal(325;3.46e-05)|Lung NSC(340;0.000601)|all_lung(284;0.000771)|Breast(348;0.00502)|Renal(390;0.00758)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;5.46e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)		TCTACTCCTTCAGAACCCCAC	0.498		NaN											0	0	0	0.012319	0	22	73									
BAI2	576	broad.mit.edu	37	1	32205546	32205546	+	Silent	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:32205546C>T	uc001btn.2	-	14	2502	c.2148G>A	c.(2146-2148)CTG>CTA	p.L716L	BAI2_uc010ogo.1_Silent_p.L358L|BAI2_uc010ogp.1_Silent_p.L649L|BAI2_uc010ogq.1_Silent_p.L716L|BAI2_uc001bto.2_Silent_p.L716L|BAI2_uc001btq.1_Silent_p.L649L|BAI2_uc010ogr.1_Missense_Mutation_p.D526N	NM_001703	NP_001694	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	716	Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(5)|breast(4)|ovary(2)|central_nervous_system(1)|skin(1)	13		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		CTGTGACAATCAGAGAGCTCT	0.552		NaN											0	0	0	0.010729	0	11	48									
SYNC	81493	broad.mit.edu	37	1	33149906	33149906	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:33149906C>G	uc001bvt.2	-	3	1411	c.1311G>C	c.(1309-1311)GAG>GAC	p.E437D	SYNC_uc010ohl.1_Missense_Mutation_p.E437D|RBBP4_uc001bvr.2_3'UTR|RBBP4_uc001bvs.2_3'UTR|RBBP4_uc010ohj.1_3'UTR|RBBP4_uc010ohk.1_3'UTR	NM_030786	NP_110413	Q9H7C4	SYNCI_HUMAN	syncoilin, intermediate filament 1 isoform 1	437	Coil 2.					intermediate filament|perinuclear region of cytoplasm	structural molecule activity			ovary(1)	1						GCTGTTCCATCTCTTTGTTCT	0.463		NaN											0	0	0	0.01441	0	59	152									
KIAA1522	57648	broad.mit.edu	37	1	33236757	33236757	+	Silent	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:33236757C>T	uc001bvv.2	+	6	1936	c.1800C>T	c.(1798-1800)GTC>GTT	p.V600V	KIAA1522_uc001bvu.1_Silent_p.V659V|KIAA1522_uc010ohm.1_Silent_p.V611V|KIAA1522_uc010ohn.1_Intron	NM_020888	NP_065939	Q9P206	K1522_HUMAN	hypothetical protein LOC57648	600	Pro-rich.										0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				ACAGGTTTGTCATACCTCCTC	0.632		NaN											0	0	0	0.01441	0	68	77									
CSMD2	114784	broad.mit.edu	37	1	33992844	33992844	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:33992844C>T	uc001bxn.1	-	64	9783	c.9754G>A	c.(9754-9756)GGG>AGG	p.G3252R	CSMD2_uc001bxm.1_Missense_Mutation_p.G3396R	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3252	Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				ATGGGTCTCCCACTGGGCCGG	0.502		NaN											0	0	0	0.004482	0	7	61									
CAP1	10487	broad.mit.edu	37	1	40537148	40537148	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:40537148C>G	uc001cfa.3	+	13	1600	c.1371C>G	c.(1369-1371)TTC>TTG	p.F457L	CAP1_uc001cey.3_Missense_Mutation_p.F457L|CAP1_uc001cez.3_Missense_Mutation_p.F457L|CAP1_uc009vvz.2_Missense_Mutation_p.F457L|CAP1_uc010oje.1_Missense_Mutation_p.F374L	NM_006367	NP_006358	Q01518	CAP1_HUMAN	adenylyl cyclase-associated protein	457					activation of adenylate cyclase activity|axon guidance|establishment or maintenance of cell polarity|platelet activation|platelet degranulation|signal transduction	plasma membrane	actin binding			ovary(1)	1	Lung NSC(20;5.03e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;4.63e-18)|Epithelial(16;1.27e-16)|all cancers(16;2.3e-15)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CTGAGCAGTTCAAGACCCTAT	0.473		NaN											0	0	0	0.007413	0	18	11									
C1orf175	374977	broad.mit.edu	37	1	55118945	55118945	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:55118945G>A	uc010ooe.1	+	3	670	c.346G>A	c.(346-348)GAC>AAC	p.D116N	C1orf175_uc001cxq.2_RNA|C1orf175_uc001cxo.2_Missense_Mutation_p.D116N|C1orf175_uc010ooc.1_Intron|C1orf175_uc001cxs.2_RNA|C1orf175_uc010ood.1_Intron|C1orf175_uc010oof.1_RNA|C1orf175_uc001cxr.1_RNA|C1orf175_uc010oog.1_Missense_Mutation_p.D116N|C1orf175_uc010ooh.1_RNA|C1orf175_uc009vzq.1_RNA|C1orf175_uc001cxt.1_RNA	NM_001039464	NP_001034553	Q68CQ1	HEAT8_HUMAN	hypothetical protein LOC374977	116						integral to membrane	binding				0						CTCAAGGCCTGACTCACAGGG	0.403		NaN											0	0	0	0.01441	0	72	81									
PRKAA2	5563	broad.mit.edu	37	1	57171852	57171852	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:57171852G>A	uc001cyk.3	+	8	1452	c.1381G>A	c.(1381-1383)GAT>AAT	p.D461N		NM_006252	NP_006243	P54646	AAPK2_HUMAN	AMP-activated protein kinase alpha 2 catalytic	461					carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding	p.D461N(1)		breast(4)|ovary(1)|stomach(1)	6						TTACCTGGTTGATAACAGGAG	0.378		NaN											0	0	0	0.009535	0	30	38									
PKN2	5586	broad.mit.edu	37	1	89236127	89236127	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:89236127G>T	uc001dmn.2	+	4	939	c.597G>T	c.(595-597)CAG>CAT	p.Q199H	PKN2_uc001dmm.1_Missense_Mutation_p.Q199H|PKN2_uc010osp.1_Missense_Mutation_p.Q199H|PKN2_uc010osq.1_Missense_Mutation_p.Q42H|PKN2_uc009wcv.2_Missense_Mutation_p.Q199H	NM_006256	NP_006247	Q16513	PKN2_HUMAN	protein kinase N2	199	REM 2.				signal transduction	cytoplasm	ATP binding|histone deacetylase binding|protein kinase C activity			large_intestine(1)|lung(1)|skin(1)	3		Lung NSC(277;0.123)		all cancers(265;0.0136)|Epithelial(280;0.0301)		AGGCAGTCCAGACTAATGAAT	0.408		NaN											1	0	7.01153e-11	0.007291	7.40841e-11	27	38									
AGL	178	broad.mit.edu	37	1	100387187	100387187	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:100387187G>C	uc001dsi.1	+	34	4979	c.4579G>C	c.(4579-4581)GAG>CAG	p.E1527Q	AGL_uc001dsj.1_Missense_Mutation_p.E1527Q|AGL_uc001dsk.1_Missense_Mutation_p.E1527Q|AGL_uc001dsl.1_Missense_Mutation_p.E1527Q|AGL_uc001dsm.1_Missense_Mutation_p.E1511Q|AGL_uc001dsn.1_Missense_Mutation_p.E1510Q	NM_000642	NP_000633	P35573	GDE_HUMAN	amylo-1,6-glucosidase,	1527	4-alpha-glucanotransferase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		TACTATTCTTGAGACACTTTA	0.378		NaN											0	0	0	0.006214	0	9	42									
NRAS	4893	broad.mit.edu	37	1	115256529	115256529	+	Missense_Mutation	SNP	T	T	C	rs11554290		TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:115256529T>C	uc009wgu.2	-	3	436	c.182A>G	c.(181-183)CAA>CGA	p.Q61R		NM_002524	NP_002515	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	61	GTP.		Q -> K (in neuroblastoma cell).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.Q61R(757)|p.Q61K(537)|p.Q61L(147)|p.Q61H(95)|p.Q61P(21)|p.Q61E(9)|p.Q61?(4)|p.Q61Q(3)|p.Q61_E62>HK(1)		haematopoietic_and_lymphoid_tissue(1008)|skin(956)|thyroid(334)|large_intestine(62)|NS(60)|soft_tissue(32)|lung(31)|upper_aerodigestive_tract(25)|urinary_tract(12)|liver(10)|adrenal_gland(9)|autonomic_ganglia(8)|testis(8)|central_nervous_system(8)|prostate(8)|breast(7)|biliary_tract(6)|ovary(6)|stomach(5)|pancreas(5)|endometrium(2)|kidney(2)|cervix(2)|eye(1)	2607	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTACTCTTCTTGTCCAGCTGT	0.458	Q61L(HEPG2_LIVER)|Q61R(SKMEL2_SKIN)|Q61R(KMS27_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(IPC298_SKIN)|Q61P(TF1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(MHHES1_BONE)|Q61R(HT1197_URINARY_TRACT)|Q61L(MELJUSO_SKIN)|Q61R(ONS76_CENTRAL_NERVOUS_SYSTEM)|Q61R(KU1919_URINARY_TRACT)|Q61L(C3A_LIVER)|Q61R(TT2609C02_THYROID)|Q61R(NCIH2347_LUNG)|Q61L(KMS21BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(SW1271_LUNG)|Q61L(HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(MOLP8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	50	Mis		melanoma|MM|AML|thyroid				Noonan_syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			0	0	0	0.013726	0	34	137									
PDE4DIP	9659	broad.mit.edu	37	1	144874708	144874708	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:144874708C>G	uc001elw.3	-	30	5191	c.4900G>C	c.(4900-4902)GAG>CAG	p.E1634Q	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.E1590Q|PDE4DIP_uc001elv.3_Missense_Mutation_p.E641Q	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1634	NBPF.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GCTTTCTTCTCTTCATAGTGT	0.517		NaN	T	PDGFRB	MPD								0	0	0	0.005524	0	36	314									
NOTCH2NL	388677	broad.mit.edu	37	1	145282020	145282020	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:145282020G>A	uc001emn.3	+	5	1070	c.700G>A	c.(700-702)GAT>AAT	p.D234N	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Intron|NOTCH2NL_uc001emm.3_Missense_Mutation_p.D234N|NOTCH2NL_uc001emo.2_Intron|NOTCH2NL_uc010oyh.1_Intron	NM_203458	NP_982283	Q7Z3S9	NT2NL_HUMAN	Notch homolog 2 N-terminal like protein	234					cell differentiation|multicellular organismal development|Notch signaling pathway	cytoplasm|extracellular region	calcium ion binding			ovary(1)	1						AAAAGAACACGATGAGAATTA	0.378		NaN											0	0	0	0.010729	0	10	71									
NBPF10	100132406	broad.mit.edu	37	1	145367724	145367724	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:145367724G>C	uc001end.3	+	85	10580	c.10545G>C	c.(10543-10545)AAG>AAC	p.K3515N	NBPF9_uc010oye.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Intron|NBPF10_uc010oyk.1_Intron|NBPF10_uc010oyl.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	3440											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		AAATTGAAaagaaggggaagg	0.259		NaN											0	0	0	0.00499	0	14	125									
GOLPH3L	55204	broad.mit.edu	37	1	150620960	150620960	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:150620960G>C	uc001evj.2	-	5	912	c.695C>G	c.(694-696)TCT>TGT	p.S232C	GOLPH3L_uc010pci.1_Missense_Mutation_p.S188C	NM_018178	NP_060648	Q9H4A5	GLP3L_HUMAN	Golgi phosphoprotein 3-like	232						Golgi cisterna membrane				ovary(1)	1	all_cancers(9;3.09e-52)|all_epithelial(9;4.47e-43)|all_lung(15;1.09e-34)|Lung NSC(24;4.04e-31)|Breast(34;0.000615)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;1.2e-23)|all cancers(9;4.81e-23)|OV - Ovarian serous cystadenocarcinoma(6;1.93e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			TAGCACATCAGAGGAGTGGGC	0.473		NaN											0	0	0	0.003954	0	23	77									
GOLPH3L	55204	broad.mit.edu	37	1	150621093	150621093	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:150621093G>T	uc001evj.2	-	5	779	c.562C>A	c.(562-564)CAT>AAT	p.H188N	GOLPH3L_uc010pci.1_Missense_Mutation_p.H144N	NM_018178	NP_060648	Q9H4A5	GLP3L_HUMAN	Golgi phosphoprotein 3-like	188						Golgi cisterna membrane				ovary(1)	1	all_cancers(9;3.09e-52)|all_epithelial(9;4.47e-43)|all_lung(15;1.09e-34)|Lung NSC(24;4.04e-31)|Breast(34;0.000615)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;1.2e-23)|all cancers(9;4.81e-23)|OV - Ovarian serous cystadenocarcinoma(6;1.93e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			GTCACTGGATGAGTAGTCATG	0.443		NaN											1	0	5.68852e-11	0.004482	6.02676e-11	9	39									
LYSMD1	388695	broad.mit.edu	37	1	151137595	151137595	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:151137595C>T	uc001ewy.2	-	1	776	c.140G>A	c.(139-141)GGA>GAA	p.G47E	LYSMD1_uc010pcr.1_Intron|SCNM1_uc010pcs.1_5'Flank|SCNM1_uc001ewz.2_5'Flank|SCNM1_uc009wmn.2_5'Flank	NM_212551	NP_997716	Q96S90	LYSM1_HUMAN	LysM, putative peptidoglycan-binding, domain	47	LysM.				cell wall macromolecule catabolic process						0	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CAGGGTGTCTCCGGGCTCCAA	0.562		NaN											0	0	0	0.004656	0	26	27									
FLG	2312	broad.mit.edu	37	1	152281835	152281835	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:152281835G>C	uc001ezu.1	-	3	5563	c.5527C>G	c.(5527-5529)CAC>GAC	p.H1843D		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1843	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTGTGGCTGTGATGAGACCCT	0.532		NaN							Ichthyosis				0	0	0	0.01441	0	200	227									
DENND4B	9909	broad.mit.edu	37	1	153902811	153902811	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:153902811C>T	uc001fdd.1	-	28	4854	c.4453G>A	c.(4453-4455)GAC>AAC	p.D1485N	uc001fdc.1_Intron	NM_014856	NP_055671	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	1485										ovary(1)	1	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			TTTCGGCAGTCAATGGCCTTG	0.547		NaN											0	0	0	0.013537	0	12	34									
KCNN3	3782	broad.mit.edu	37	1	154705586	154705586	+	Silent	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:154705586G>A	uc001ffp.2	-	4	1797	c.1483C>T	c.(1483-1485)CTG>TTG	p.L495L	KCNN3_uc001ffo.2_Silent_p.L190L	NM_002249	NP_002240	Q9UGI6	KCNN3_HUMAN	small conductance calcium-activated potassium	500						integral to membrane	calmodulin binding			lung(1)	1	all_lung(78;2.29e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.108)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00819)			ATGGCACCCAGAAAGTTACTA	0.517		NaN											0	0	0	0.003163	0	15	53									
HCN3	57657	broad.mit.edu	37	1	155257083	155257083	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:155257083C>T	uc001fjz.1	+	7	1605	c.1597C>T	c.(1597-1599)CGC>TGC	p.R533C	RAG1AP1_uc010pey.1_Intron|HCN3_uc010pfz.1_Missense_Mutation_p.R228C	NM_020897	NP_065948	Q9P1Z3	HCN3_HUMAN	hyperpolarization activated cyclic	533	Cytoplasmic (Potential).|cAMP.					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)|breast(1)	2	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CCCCATGATGCGCCGGGCCTT	0.617		NaN											0	0	0	0.012319	0	18	63									
CD1A	909	broad.mit.edu	37	1	158227240	158227240	+	Missense_Mutation	SNP	T	T	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:158227240T>G	uc001frt.2	+	5	1446	c.913T>G	c.(913-915)TTG>GTG	p.L305V		NM_001763	NP_001754	P06126	CD1A_HUMAN	CD1A antigen precursor	305	Helical; (Potential).				antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	CTTCATCATCTTGGCGGTGAT	0.413		NaN											0	0	0	0.01441	0	72	243									
OR6K6	128371	broad.mit.edu	37	1	158725183	158725183	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:158725183C>T	uc001fsw.1	+	1	578	c.578C>T	c.(577-579)ACC>ATC	p.T193I		NM_001005184	NP_001005184	Q8NGW6	OR6K6_HUMAN	olfactory receptor, family 6, subfamily K,	193	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_hematologic(112;0.0378)					TGGATTTCCACCTTGCCTTTC	0.478		NaN											0	0	0	0.00623	0	41	45									
IGSF9	57549	broad.mit.edu	37	1	159906269	159906269	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:159906269C>T	uc001fur.2	-	6	791	c.593G>A	c.(592-594)CGA>CAA	p.R198Q	IGSF9_uc001fuq.2_Missense_Mutation_p.R198Q	NM_001135050	NP_001128522	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9 isoform a	198	Ig-like 2.|Extracellular (Potential).					cell junction|integral to membrane|synapse				ovary(2)|central_nervous_system(2)|large_intestine(1)	5	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			AGAGCTGCCTCGCTCTACCCG	0.657		NaN									OREG0013921	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00278	0	20	50									
CD84	8832	broad.mit.edu	37	1	160523264	160523264	+	Missense_Mutation	SNP	G	G	C	rs145496946		TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:160523264G>C	uc001fwh.3	-	4	688	c.664C>G	c.(664-666)CAC>GAC	p.H222D	CD84_uc001fwf.3_Missense_Mutation_p.H222D|CD84_uc001fwg.3_Missense_Mutation_p.H222D|CD84_uc009wtn.2_Missense_Mutation_p.H222D|CD84_uc001fwi.3_Missense_Mutation_p.H108D|CD84_uc001fwj.2_Missense_Mutation_p.H222D	NM_003874	NP_003865	Q9UIB8	SLAF5_HUMAN	CD84 molecule	222	Extracellular (Potential).				blood coagulation|defense response|homophilic cell adhesion|leukocyte migration	integral to plasma membrane	receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(52;3.62e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			CCGGTGTGGTGAGTACGGAAG	0.488		NaN											0	0	0	0.014323	0	21	46									
PAPPA2	60676	broad.mit.edu	37	1	176564329	176564329	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:176564329T>C	uc001gkz.2	+	3	2753	c.1589T>C	c.(1588-1590)GTG>GCG	p.V530A	PAPPA2_uc001gky.1_Missense_Mutation_p.V530A|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	530	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						TACCAGGTGGTGAACATCTGT	0.527		NaN											0	0	0	0.007413	0	19	28									
SOAT1	6646	broad.mit.edu	37	1	179320465	179320465	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:179320465C>G	uc001gml.2	+	15	1527	c.1464C>G	c.(1462-1464)TTC>TTG	p.F488L	SOAT1_uc010pni.1_Missense_Mutation_p.F423L|SOAT1_uc001gmm.2_Missense_Mutation_p.F430L|SOAT1_uc010pnj.1_Missense_Mutation_p.F224L|SOAT1_uc010pnk.1_Missense_Mutation_p.F423L	NM_003101	NP_003092	P35610	SOAT1_HUMAN	sterol O-acyltransferase 1	488	Helical; (Potential).				cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|cholesterol storage|macrophage derived foam cell differentiation|positive regulation of amyloid precursor protein biosynthetic process|very-low-density lipoprotein particle assembly	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			central_nervous_system(1)|skin(1)	2					Ezetimibe(DB00973)|Hesperetin(DB01094)	CTTTCAACTTCATTGTCAATG	0.274		NaN											0	0	0	0.00874	0	39	97									
HMCN1	83872	broad.mit.edu	37	1	186007984	186007984	+	Missense_Mutation	SNP	C	C	T	rs149920975		TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:186007984C>T	uc001grq.1	+	38	6104	c.5875C>T	c.(5875-5877)CGT>TGT	p.R1959C		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	1959	Ig-like C2-type 17.			R -> C (in Ref. 1).	response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						CAAAGATAATCGTCTACTCTC	0.348		NaN											0	0	0	0.004007	0	13	96									
ASPM	259266	broad.mit.edu	37	1	197070512	197070512	+	Missense_Mutation	SNP	T	T	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:197070512T>G	uc001gtu.2	-	18	8126	c.7869A>C	c.(7867-7869)GAA>GAC	p.E2623D	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Missense_Mutation_p.E471D	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	2623					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						CCTGGTGCTGTTCCTGAATCT	0.343		NaN											0	0	0	0.001855	0	13	12									
TNNI1	7135	broad.mit.edu	37	1	201380568	201380568	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:201380568G>A	uc010ppq.1	-	7	466	c.373C>T	c.(373-375)CGG>TGG	p.R125W	TNNI1_uc001gwo.1_RNA|TNNI1_uc001gwp.2_Missense_Mutation_p.R104W	NM_003281	NP_003272	P19237	TNNI1_HUMAN	troponin I, skeletal, slow	125					muscle filament sliding|regulation of striated muscle contraction	cytosol|troponin complex	actin binding|tropomyosin binding				0						AGCAGGGCCCGGAGCATGGCG	0.597		NaN											0	0	0	0.004007	0	17	20									
OBSCN	84033	broad.mit.edu	37	1	228509288	228509288	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:228509288C>T	uc009xez.1	+	55	14790	c.14746C>T	c.(14746-14748)CGG>TGG	p.R4916W	OBSCN_uc001hsn.2_Missense_Mutation_p.R4916W	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	4916	Ig-like 48.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GGATGCCCTGCGGCTGGAGTG	0.617		NaN											0	0	0	0.008871	0	17	21									
ACTN2	88	broad.mit.edu	37	1	236908062	236908062	+	Silent	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:236908062C>T	uc001hyf.2	+	12	1596	c.1392C>T	c.(1390-1392)ATC>ATT	p.I464I	ACTN2_uc001hyg.2_Silent_p.I256I|ACTN2_uc009xgi.1_Silent_p.I464I|ACTN2_uc010pxu.1_Silent_p.I153I|ACTN2_uc001hyh.2_Silent_p.I152I	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	464	Spectrin 2.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			TCGCAGCCATCGCGCAGGAGC	0.657		NaN											0	0	0	0.00499	0	16	37									
ZP4	57829	broad.mit.edu	37	1	238053789	238053789	+	Silent	SNP	T	T	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:238053789T>C	uc001hym.2	-	1	147	c.147A>G	c.(145-147)GCA>GCG	p.A49A	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	49	Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			GAGGAGACGTTGCCTCCTGGT	0.498		NaN											0	0	0	0.000602	0	4	34									
CHRM3	1131	broad.mit.edu	37	1	240071762	240071762	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:240071762G>C	uc001hyp.2	+	5	1790	c.1011G>C	c.(1009-1011)TGG>TGC	p.W337C		NM_000740	NP_000731	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	337	Cytoplasmic (By similarity).				cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(1)	5	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	GTGACAGTTGGAACAACAATG	0.572		NaN											0	0	0	0.001984	0	7	13									
CHRM3	1131	broad.mit.edu	37	1	240071792	240071792	+	Silent	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:240071792G>A	uc001hyp.2	+	5	1820	c.1041G>A	c.(1039-1041)GAG>GAA	p.E347E		NM_000740	NP_000731	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	347	Cytoplasmic (By similarity).				cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(1)	5	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	CCTCCCTGGAGAACTCCGCCT	0.572		NaN											0	0	0	0.001168	0	5	9									
NLRP3	114548	broad.mit.edu	37	1	247588705	247588705	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:247588705G>A	uc001icr.2	+	5	2098	c.1960G>A	c.(1960-1962)GAG>AAG	p.E654K	NLRP3_uc001ics.2_Missense_Mutation_p.E654K|NLRP3_uc001icu.2_Missense_Mutation_p.E654K|NLRP3_uc001icw.2_Missense_Mutation_p.E654K|NLRP3_uc001icv.2_Missense_Mutation_p.E654K|NLRP3_uc010pyw.1_Missense_Mutation_p.E652K|NLRP3_uc001ict.1_Missense_Mutation_p.E652K	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	654					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			CCCCAAGATTGAGATCAATCT	0.498		NaN											0	0	0	0.008291	0	11	36									
FBXO18	84893	broad.mit.edu	37	10	5955750	5955750	+	Missense_Mutation	SNP	A	A	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr10:5955750A>T	uc001iis.2	+	7	1347	c.1252A>T	c.(1252-1254)AAT>TAT	p.N418Y	FBXO18_uc001iir.2_Missense_Mutation_p.N344Y|FBXO18_uc009xig.2_Missense_Mutation_p.N344Y|FBXO18_uc001iit.2_Missense_Mutation_p.N469Y	NM_178150	NP_835363	Q8NFZ0	FBX18_HUMAN	F-box only protein, helicase, 18 isoform 2	418					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(2)|skin(1)	3						TCTTCAGGAGAATTCCTGCAC	0.398		NaN											0	0	0	0.001168	0	5	69									
PFKFB3	5209	broad.mit.edu	37	10	6258137	6258137	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr10:6258137G>T	uc001ije.2	+	4	733	c.349G>T	c.(349-351)GAA>TAA	p.E117*	PFKFB3_uc001ijd.2_Nonsense_Mutation_p.E97*|PFKFB3_uc009xii.2_RNA|PFKFB3_uc010qaw.1_Nonsense_Mutation_p.E131*|PFKFB3_uc001ijf.2_Nonsense_Mutation_p.E117*	NM_004566	NP_004557	Q16875	F263_HUMAN	6-phosphofructo-2-kinase/fructose-2,	117	6-phosphofructo-2-kinase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding			ovary(2)|central_nervous_system(1)	3						CCTGGCGAAAGAAGGGGGACA	0.587		NaN											1	0	8.20599e-20	0.011902	8.81301e-20	41	51									
SUV39H2	79723	broad.mit.edu	37	10	14939477	14939477	+	Silent	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr10:14939477G>A	uc001inh.2	+	2	686	c.630G>A	c.(628-630)AAG>AAA	p.K210K	SUV39H2_uc001ing.2_Intron|SUV39H2_uc001ini.2_Silent_p.K210K|SUV39H2_uc001inj.2_Silent_p.K210K	NM_024670	NP_078946	Q9H5I1	SUV92_HUMAN	suppressor of variegation 3-9 homolog 2	270	SET.				cell cycle|cell differentiation|chromatin assembly or disassembly|chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin|chromosome, centromeric region|nucleus	histone methyltransferase activity (H3-K9 specific)|protein binding|zinc ion binding			breast(2)|ovary(1)	3						CCCTTGTGAAGATTAAAAGAA	0.388		NaN											0	0	0	0.001855	0	12	37									
NMT2	9397	broad.mit.edu	37	10	15174885	15174885	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr10:15174885C>G	uc001inz.1	-	6	734	c.650G>C	c.(649-651)AGA>ACA	p.R217T	NMT2_uc001ioa.1_Missense_Mutation_p.R204T|NMT2_uc009xjo.1_Missense_Mutation_p.R217T|NMT2_uc010qbz.1_Missense_Mutation_p.R29T	NM_004808	NP_004799	O60551	NMT2_HUMAN	N-myristoyltransferase 2	217					N-terminal protein myristoylation|protein lipoylation	Golgi apparatus|plasma membrane	glycylpeptide N-tetradecanoyltransferase activity			ovary(1)	1						TGAAGACACTCTGACCCCACA	0.493		NaN											0	0	0	0.003163	0	16	55									
LRRTM3	347731	broad.mit.edu	37	10	68686706	68686706	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr10:68686706G>A	uc001jmz.1	+	2	582	c.32G>A	c.(31-33)GGA>GAA	p.G11E	CTNNA3_uc009xpn.1_Intron|CTNNA3_uc001jmw.2_Intron|CTNNA3_uc001jmx.3_Intron|CTNNA3_uc009xpo.1_Intron|LRRTM3_uc001jmy.2_Missense_Mutation_p.G11E	NM_178011	NP_821079	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	11						integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						CTACTGAGCGGATCAGCTGTA	0.418		NaN											0	0	0	0.004007	0	13	29									
POLR3A	11128	broad.mit.edu	37	10	79740028	79740028	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr10:79740028C>A	uc001jzn.2	-	30	3989	c.3895G>T	c.(3895-3897)GAA>TAA	p.E1299*		NM_007055	NP_008986	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	1299					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding				0	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			CCCAGGACTTCACCCTGCGTC	0.517		NaN											1	0	1.15088e-07	0.004007	1.20305e-07	16	22									
POLR3A	11128	broad.mit.edu	37	10	79741314	79741314	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr10:79741314C>T	uc001jzn.2	-	29	3857	c.3763G>A	c.(3763-3765)GAG>AAG	p.E1255K		NM_007055	NP_008986	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	1255					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding				0	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			AGAGTTTTCTCCACCTACAGA	0.542		NaN											0	0	0	0.01441	0	127	162									
SEC31B	25956	broad.mit.edu	37	10	102249108	102249108	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr10:102249108C>T	uc001krc.1	-	23	3174	c.3072G>A	c.(3070-3072)ATG>ATA	p.M1024I	SEC31B_uc010qpo.1_Missense_Mutation_p.M1023I|SEC31B_uc001krd.1_Missense_Mutation_p.M561I|SEC31B_uc001krf.1_Missense_Mutation_p.M456I|SEC31B_uc001kre.1_Missense_Mutation_p.M456I	NM_015490	NP_056305	Q9NQW1	SC31B_HUMAN	SEC31 homolog B	1024	Pro-rich.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				ovary(1)	1		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)		GGGTGAGGCTCATAACTGGAG	0.537		NaN											0	0	0	0.014323	0	22	37									
BTBD16	118663	broad.mit.edu	37	10	124036305	124036305	+	Splice_Site	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr10:124036305G>A	uc001lgc.1	+	3	270	c.19_splice	c.e3-1	p.H7_splice	BTBD16_uc001lgd.1_Silent_p.Q5Q	NM_144587	NP_653188	Q32M84	BTBDG_HUMAN	BTB (POZ) domain containing 16											skin(1)	1		all_neural(114;0.107)|Lung NSC(174;0.175)|all_lung(145;0.222)|Breast(234;0.238)				TTACCAAGCAGCACAAAGCTC	0.448		NaN											0	0	0	0.004672	0	3	97									
MMP21	118856	broad.mit.edu	37	10	127464241	127464241	+	Silent	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr10:127464241G>C	uc001liu.2	-	1	150	c.150C>G	c.(148-150)CTC>CTG	p.L50L		NM_147191	NP_671724	Q8N119	MMP21_HUMAN	matrix metalloproteinase 21 preproprotein	50					proteolysis	extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				GAGCAGCGTGGAGGTCGGCAA	0.682		NaN											0	0	0	0.008361	0	28	28									
DOCK1	1793	broad.mit.edu	37	10	129224163	129224163	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr10:129224163G>A	uc001ljt.2	+	47	4803	c.4739G>A	c.(4738-4740)AGA>AAA	p.R1580K	DOCK1_uc010qun.1_Missense_Mutation_p.R1601K|DOCK1_uc009yaq.2_Missense_Mutation_p.R575K	NM_001380	NP_001371	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1580	DHR-2.				apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		GAAGGGATCAGAATCCATGGA	0.493		NaN											0	0	0	0.005524	0	39	191									
BNIP3	664	broad.mit.edu	37	10	133786615	133786615	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr10:133786615G>A	uc001lkv.1	-	3	331	c.205C>T	c.(205-207)CGC>TGC	p.R69C	BNIP3_uc001lku.1_5'Flank|BNIP3_uc010qut.1_Missense_Mutation_p.R69C	NM_004052	NP_004043	Q12983	BNIP3_HUMAN	BCL2/adenovirus E1B 19kD-interacting protein 3	69					cellular response to cobalt ion|cellular response to hypoxia|cellular response to mechanical stimulus|chromatin remodeling|defense response to virus|DNA fragmentation involved in apoptotic nuclear change|induction of apoptosis|interspecies interaction between organisms|mitochondrial fragmentation involved in apoptosis|negative regulation of membrane potential|negative regulation of mitochondrial fusion|negative regulation of survival gene product expression|neuron apoptosis|positive regulation of mitochondrial fission|positive regulation of protein complex disassembly|positive regulation of release of cytochrome c from mitochondria|reactive oxygen species metabolic process|regulation of mitochondrial membrane permeability	dendrite|integral to mitochondrial outer membrane|nuclear envelope|nucleoplasm	GTPase binding|protein heterodimerization activity|protein homodimerization activity			lung(1)|skin(1)	2		all_cancers(35;4e-11)|all_epithelial(44;5.07e-08)|Ovarian(717;2.61e-05)|Lung NSC(174;0.00237)|all_lung(145;0.00354)|Breast(234;0.023)|all_neural(114;0.0299)|Colorectal(31;0.109)|Melanoma(40;0.123)|Glioma(114;0.203)		Epithelial(32;1.59e-12)|all cancers(32;3.75e-11)|OV - Ovarian serous cystadenocarcinoma(35;2.57e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		GTCTGCGAGCGAGGTGGGCTT	0.468		NaN											0	0	0	0.006999	0	39	118									
MRGPRE	116534	broad.mit.edu	37	11	3249790	3249790	+	Silent	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr11:3249790G>A	uc001lxq.3	-	2	547	c.237C>T	c.(235-237)ATC>ATT	p.I79I		NM_001039165	NP_001034254	Q86SM8	MRGRE_HUMAN	MAS-related GPR, member E	79	Helical; Name=2; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(1)|ovary(1)	2		Medulloblastoma(188;0.00106)|all_epithelial(84;0.00111)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00529)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGTCGGGGACGATGGCCACCA	0.622		NaN											0	0	0	0.01441	0	62	31									
CHRNA10	57053	broad.mit.edu	37	11	3687403	3687403	+	Silent	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr11:3687403G>A	uc001lyf.2	-	5	1359	c.1287C>T	c.(1285-1287)TTC>TTT	p.F429F	CHRNA10_uc010qxt.1_Silent_p.F223F|CHRNA10_uc010qxu.1_Silent_p.F223F	NM_020402	NP_065135	Q9GZZ6	ACH10_HUMAN	cholinergic receptor, nicotinic, alpha 10	429	Helical; (Potential).				elevation of cytosolic calcium ion concentration|regulation of cell proliferation|synaptic transmission, cholinergic	cell junction|postsynaptic membrane	calcium channel activity|receptor activity|receptor binding			ovary(1)	1		Medulloblastoma(188;0.0075)|Breast(177;0.0164)|all_neural(188;0.0577)		BRCA - Breast invasive adenocarcinoma(625;0.0344)|LUSC - Lung squamous cell carcinoma(625;0.192)	Chloroprocaine(DB01161)|Methadone(DB00333)|Nicotine(DB00184)|Pentolinium(DB01090)|Procaine(DB00721)|Trimethaphan(DB01116)	TGGCCAGGAAGAAGCGGTCCA	0.627		NaN											0	0	0	0.01441	0	49	20									
OR52B4	143496	broad.mit.edu	37	11	4388815	4388815	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr11:4388815G>C	uc010qye.1	-	1	711	c.711C>G	c.(709-711)CAC>CAG	p.H237Q		NM_001005161	NP_001005161	Q8NGK2	O52B4_HUMAN	olfactory receptor, family 52, subfamily B,	237	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0249)|all_neural(188;0.0577)		Epithelial(150;1.57e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0826)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGAGAGCTTTGTGGCAAGCAT	0.443		NaN											0	0	0	0.00308	0	8	81									
OR51B6	390058	broad.mit.edu	37	11	5373369	5373369	+	Missense_Mutation	SNP	T	T	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr11:5373369T>A	uc010qzb.1	+	1	632	c.632T>A	c.(631-633)ATC>AAC	p.I211N	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004750	NP_001004750	Q9H340	O51B6_HUMAN	olfactory receptor, family 51, subfamily B,	211	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GACTTTCTCATCATCTTTTTC	0.443		NaN											0	0	0	0.01441	0	44	28									
DBX1	120237	broad.mit.edu	37	11	20181520	20181520	+	Silent	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr11:20181520G>A	uc001mpw.1	-	1	351	c.351C>T	c.(349-351)TCC>TCT	p.S117S		NM_001029865	NP_001025036	A6NMT0	DBX1_HUMAN	developing brain homeobox 1	117					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TGGGCCCCGAGGAGAGGATGG	0.642		NaN											0	0	0	0.009096	0	4	20									
GAS2	2620	broad.mit.edu	37	11	22759311	22759311	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr11:22759311C>G	uc009yie.2	+	5	776	c.470C>G	c.(469-471)GCC>GGC	p.A157G	GAS2_uc001mqm.2_Missense_Mutation_p.A157G|GAS2_uc001mqn.2_RNA|GAS2_uc001mqo.2_Missense_Mutation_p.A157G	NM_001143830	NP_001137302	O43903	GAS2_HUMAN	growth arrest-specific 2	157					cell cycle arrest|cellular component disassembly involved in apoptosis|regulation of cell shape	actin filament|cytosol|membrane				ovary(1)|skin(1)	2						CGGATTGCAGCCAGGTAGGTC	0.468		NaN											0	0	0	0.013537	0	12	52									
C11orf49	79096	broad.mit.edu	37	11	47183188	47183188	+	Silent	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr11:47183188G>A	uc001ndp.2	+	9	1101	c.995G>A	c.(994-996)TGA>TAA	p.*332*	C11orf49_uc001nds.2_Intron|C11orf49_uc001ndq.2_3'UTR|C11orf49_uc001ndr.2_Silent_p.*338*|C11orf49_uc010rgx.1_Silent_p.*235*|C11orf49_uc010rgy.1_Silent_p.*323*|C11orf49_uc010rgz.1_Silent_p.*248*	NM_024113	NP_077018	Q9H6J7	CK049_HUMAN	hypothetical protein LOC79096 isoform 3	332											0						TCGGAGACTTGAGGAGTCCAA	0.622		NaN									OREG0020950	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.007291	0	28	10									
OR5L1	219437	broad.mit.edu	37	11	55579623	55579623	+	Silent	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr11:55579623G>A	uc001nhw.1	+	1	681	c.681G>A	c.(679-681)AAG>AAA	p.K227K		NM_001004738	NP_001004738	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L,	227	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(2)	5		all_epithelial(135;0.208)				CCATCCTGAAGATGGGCTCTG	0.498		NaN											0	0	0	0.00278	0	24	73									
SPRYD5	84767	broad.mit.edu	37	11	55658689	55658689	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr11:55658689G>C	uc010rip.1	+	7	1032	c.940G>C	c.(940-942)GAC>CAC	p.D314H	SPRYD5_uc010riq.1_Missense_Mutation_p.D171H	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	314	B30.2/SPRY.					intracellular	zinc ion binding				0		all_epithelial(135;0.226)				TGTTGGATGTGACCCTCAAGA	0.388		NaN											0	0	0	0.01441	0	80	46									
PC	5091	broad.mit.edu	37	11	66618514	66618514	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr11:66618514G>C	uc001ojn.1	-	15	2269	c.2220C>G	c.(2218-2220)ATC>ATG	p.I740M	PC_uc001ojo.1_Missense_Mutation_p.I740M|PC_uc001ojp.1_Missense_Mutation_p.I740M|PC_uc001ojm.1_5'Flank	NM_022172	NP_071504	P11498	PYC_HUMAN	pyruvate carboxylase precursor	740	Carboxyltransferase.				gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			ovary(2)|lung(1)|kidney(1)	4		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	CAGGCACCTTGATGCACAGGA	0.647		NaN											0	0	0	0.003755	0	37	12									
SAPS3	55291	broad.mit.edu	37	11	68363617	68363617	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr11:68363617G>A	uc001onw.2	+	19	2236	c.1969G>A	c.(1969-1971)GCA>ACA	p.A657T	SAPS3_uc001onv.2_Missense_Mutation_p.A657T|SAPS3_uc001ony.3_Missense_Mutation_p.A628T|SAPS3_uc001onx.2_Missense_Mutation_p.A651T|SAPS3_uc009ysh.2_Missense_Mutation_p.A577T|SAPS3_uc001onu.2_Missense_Mutation_p.A577T|SAPS3_uc010rqc.1_Missense_Mutation_p.A425T|SAPS3_uc010rqd.1_Missense_Mutation_p.A340T|SAPS3_uc001onz.2_5'UTR|SAPS3_uc001ooa.2_Missense_Mutation_p.A107T	NM_001164161	NP_001157633	Q5H9R7	PP6R3_HUMAN	SAPS domain family, member 3 isoform 6	657					regulation of phosphoprotein phosphatase activity	cytoplasm|nucleus	protein phosphatase binding				0			LUAD - Lung adenocarcinoma(13;0.102)			AGAAGATGGAGCAAAGCAAGA	0.463		NaN											0	0	0	0.004672	0	3	75									
USP35	57558	broad.mit.edu	37	11	77921098	77921098	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr11:77921098G>A	uc009yva.1	+	10	2443	c.2197G>A	c.(2197-2199)GAA>AAA	p.E733K	USP35_uc001oze.2_Missense_Mutation_p.E489K|USP35_uc001ozc.2_Missense_Mutation_p.E301K|USP35_uc010rsp.1_Missense_Mutation_p.E165K|USP35_uc001ozd.2_Missense_Mutation_p.E344K|USP35_uc001ozf.2_Missense_Mutation_p.E464K	NM_020798	NP_065849	Q9P2H5	UBP35_HUMAN	ubiquitin specific protease 35	733					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)	3	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.04e-25)			ggaaaaggaagaagaCAGCCT	0.333		NaN											0	0	0	0.013726	0	34	20									
NOX4	50507	broad.mit.edu	37	11	89106617	89106617	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr11:89106617A>G	uc001pct.2	-	12	1357	c.1118T>C	c.(1117-1119)ATA>ACA	p.I373T	NOX4_uc009yvr.2_Missense_Mutation_p.I348T|NOX4_uc001pcu.2_Missense_Mutation_p.I299T|NOX4_uc001pcw.2_Missense_Mutation_p.I66T|NOX4_uc001pcx.2_Missense_Mutation_p.I66T|NOX4_uc001pcv.2_Missense_Mutation_p.I373T|NOX4_uc009yvo.2_RNA|NOX4_uc010rtu.1_Missense_Mutation_p.I207T|NOX4_uc009yvp.2_Intron|NOX4_uc010rtv.1_Missense_Mutation_p.I349T|NOX4_uc009yvq.2_Missense_Mutation_p.I349T	NM_016931	NP_058627	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4 isoform a	373	FAD-binding FR-type.|Extracellular (Potential).|Mediates interaction with TLR4.				cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				GTCTCCTACTATTTTAAGATG	0.264		NaN											0	0	0	0.01441	0	104	48									
FAT3	120114	broad.mit.edu	37	11	92539552	92539552	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr11:92539552G>A	uc001pdj.3	+	11	9135	c.9118G>A	c.(9118-9120)GAA>AAA	p.E3040K		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	3040	Cadherin 28.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ATTACTTCCTGAAGACATTCC	0.358		NaN								TCGA Ovarian(4;0.039)			0	0	0	0.008291	0	11	5									
VPS11	55823	broad.mit.edu	37	11	118948238	118948238	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr11:118948238G>A	uc010ryx.1	+	10	1495	c.1453G>A	c.(1453-1455)GAT>AAT	p.D485N	VPS11_uc010ryy.1_Missense_Mutation_p.D331N	NM_021729	NP_068375	Q9H270	VPS11_HUMAN	vacuolar protein sorting 11	485	Clathrin.				protein transport	endocytic vesicle|HOPS complex|late endosome membrane|lysosomal membrane	nucleotide binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.88e-05)		AGTCCACTTTGATGTGGAGAC	0.507		NaN											0	0	0	0.005524	0	33	12									
OR10S1	219873	broad.mit.edu	37	11	123848240	123848240	+	Silent	SNP	A	A	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr11:123848240A>C	uc001pzm.1	-	1	159	c.159T>G	c.(157-159)GCT>GCG	p.A53A		NM_001004474	NP_001004474	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S,	53	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		GGAGATTCCCAGCCACAGTGA	0.532		NaN											0	0	0	0.00245	0	14	17									
SLC6A13	6540	broad.mit.edu	37	12	344379	344379	+	Silent	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:344379G>A	uc001qic.1	-	7	761	c.708C>T	c.(706-708)TTC>TTT	p.F236F	SLC6A13_uc009zdj.1_Silent_p.F236F|SLC6A13_uc010sdl.1_Silent_p.F144F|SLC6A13_uc010sdm.1_Silent_p.F117F	NM_016615	NP_057699	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter	236	Helical; Name=5; (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			ATGTGGCCGTGAAGTACACCA	0.433		NaN											0	0	0	0.001984	0	5	20									
LRTM2	654429	broad.mit.edu	37	12	1940449	1940449	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:1940449C>T	uc001qjt.2	+	4	1222	c.416C>T	c.(415-417)TCG>TTG	p.S139L	CACNA2D4_uc001qjp.2_Intron|CACNA2D4_uc009zds.1_Intron|CACNA2D4_uc009zdt.1_Intron|CACNA2D4_uc009zdr.1_Intron|LRTM2_uc001qju.2_Missense_Mutation_p.S139L|LRTM2_uc010sdx.1_Missense_Mutation_p.S139L|LRTM2_uc001qjv.2_Intron	NM_001039029	NP_001034118	Q8N967	LRTM2_HUMAN	leucine-rich repeats and transmembrane domains 2	139	Extracellular (Potential).|LRR 3.					integral to membrane				large_intestine(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000834)			CTGCGGCACTCGCCGCTGCTC	0.652		NaN											0	0	0	0.010504	0	20	58									
PZP	5858	broad.mit.edu	37	12	9346775	9346775	+	Silent	SNP	C	C	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:9346775C>G	uc001qvl.2	-	11	1181	c.1152G>C	c.(1150-1152)GTG>GTC	p.V384V	PZP_uc009zgl.2_Silent_p.V253V	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						TGGCGTCATTCACAGAGATGA	0.408		NaN											0	0	0	0.010504	0	20	38									
SFRS2IP	9169	broad.mit.edu	37	12	46342235	46342235	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:46342235G>C	uc001rox.2	-	5	670	c.383C>G	c.(382-384)TCT>TGT	p.S128C	SFRS2IP_uc001roy.1_Missense_Mutation_p.S202C	NM_004719	NP_004710	Q99590	SCAFB_HUMAN	splicing factor, arginine/serine-rich 2,	128					spliceosome assembly	nucleus	protein binding|zinc ion binding				0	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.209)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.1)		ACAGCTTTTAGAATTTTCATG	0.313		NaN											0	0	0	0.001855	0	14	46									
SUOX	6821	broad.mit.edu	37	12	56397462	56397462	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:56397462G>C	uc001six.2	+	6	615	c.289G>C	c.(289-291)GAG>CAG	p.E97Q	SUOX_uc001siy.2_Missense_Mutation_p.E97Q|SUOX_uc001siz.2_Missense_Mutation_p.E97Q|SUOX_uc001sja.2_Missense_Mutation_p.E97Q	NM_000456	NP_000447	P51687	SUOX_HUMAN	sulfite oxidase precursor	97	Cytochrome b5 heme-binding.					mitochondrial intermembrane space	electron carrier activity|molybdenum ion binding|sulfite oxidase activity				0			UCEC - Uterine corpus endometrioid carcinoma (6;0.0471)|OV - Ovarian serous cystadenocarcinoma(18;0.119)			CACCAGCCCTGAGACTGGGAT	0.512		NaN											0	0	0	0.007413	0	19	86									
ERBB3	2065	broad.mit.edu	37	12	56486584	56486584	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:56486584G>A	uc001sjh.2	+	10	1356	c.1163G>A	c.(1162-1164)CGG>CAG	p.R388Q	ERBB3_uc009zoj.2_Intron|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Missense_Mutation_p.R329Q|ERBB3_uc009zok.2_5'Flank|ERBB3_uc001sjj.1_5'Flank	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	388	Extracellular (Potential).				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			AATGTCTTCCGGACAGTACGG	0.448		NaN											0	0	0	0.00245	0	12	123									
LRP1	4035	broad.mit.edu	37	12	57579595	57579595	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:57579595C>T	uc001snd.2	+	41	7211	c.6745C>T	c.(6745-6747)CCG>TCG	p.P2249S		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	2249	Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	AGGCACCTCTCCGGGCACCCC	0.577		NaN											0	0	0	0.01441	0	47	44									
USP15	9958	broad.mit.edu	37	12	62790135	62790135	+	Silent	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:62790135G>C	uc001src.1	+	20	2640	c.2631G>C	c.(2629-2631)CTG>CTC	p.L877L	USP15_uc001srb.1_Silent_p.L848L	NM_006313	NP_006304	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	877					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|lung(1)	3			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		GCTATAATCTGATTGCTGTTT	0.393		NaN											0	0	0	0.013537	0	12	54									
CAPS2	84698	broad.mit.edu	37	12	75676043	75676043	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:75676043G>A	uc001sxk.3	-	17	1854	c.1657C>T	c.(1657-1659)CAA>TAA	p.Q553*	CAPS2_uc001sxm.3_Nonsense_Mutation_p.Q321*|CAPS2_uc009zsa.2_Nonsense_Mutation_p.Q143*|CAPS2_uc001sxi.3_Nonsense_Mutation_p.Q289*|CAPS2_uc001sxj.3_Nonsense_Mutation_p.Q464*|CAPS2_uc001sxl.3_Nonsense_Mutation_p.Q534*	NM_032606	NP_115995	Q9BXY5	CAYP2_HUMAN	calcyphosine 2	553							calcium ion binding			ovary(2)	2						GAAATTACTTGAGAATGCTTC	0.284		NaN											0	0	0	0.010504	0	21	106									
MYF5	4617	broad.mit.edu	37	12	81111211	81111211	+	Silent	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:81111211C>T	uc001szg.2	+	1	504	c.369C>T	c.(367-369)ATC>ATT	p.I123I		NM_005593	NP_005584	P13349	MYF5_HUMAN	myogenic factor 5	123	Helix-loop-helix motif.				muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(1)	1						AGGTGGAGATCCTCAGGAATG	0.597		NaN											0	0	0	0.00278	0	22	134									
CCDC38	120935	broad.mit.edu	37	12	96312708	96312708	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:96312708G>C	uc001tek.1	-	3	318	c.84C>G	c.(82-84)ATC>ATG	p.I28M		NM_182496	NP_872302	Q502W7	CCD38_HUMAN	coiled-coil domain containing 38	28										skin(1)	1						CTCTGAAAAAGATCTTATAAG	0.338		NaN											0	0	0	0.001855	0	12	86									
GAS2L3	283431	broad.mit.edu	37	12	101017394	101017394	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:101017394C>T	uc001thu.2	+	10	1037	c.811C>T	c.(811-813)CAA>TAA	p.Q271*	GAS2L3_uc009zty.2_Nonsense_Mutation_p.Q271*|GAS2L3_uc001thv.2_Nonsense_Mutation_p.Q167*	NM_174942	NP_777602	Q86XJ1	GA2L3_HUMAN	growth arrest-specific 2 like 3	271	GAR.				cell cycle arrest					skin(1)	1						GGATACTCTTCAAGGATTTTT	0.378		NaN											0	0	0	0.01441	0	74	59									
APPL2	55198	broad.mit.edu	37	12	105570747	105570747	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:105570747C>G	uc001tlf.1	-	19	1937	c.1719G>C	c.(1717-1719)AAG>AAC	p.K573N	APPL2_uc010swt.1_Missense_Mutation_p.K530N|APPL2_uc001tlg.1_Missense_Mutation_p.K327N|APPL2_uc010swu.1_Missense_Mutation_p.K579N	NM_018171	NP_060641	Q8NEU8	DP13B_HUMAN	adaptor protein, phosphotyrosine interaction, PH	573	PID.				cell cycle|cell proliferation|signal transduction	early endosome membrane|nucleus	protein binding			upper_aerodigestive_tract(1)	1						CAACCAGTCTCTTGTTTTCTT	0.398		NaN											0	0	0	0.007291	0	30	34									
POLR3B	55703	broad.mit.edu	37	12	106820987	106820987	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:106820987C>T	uc001tlp.2	+	13	1336	c.1114C>T	c.(1114-1116)CTT>TTT	p.L372F	POLR3B_uc001tlq.2_Missense_Mutation_p.L314F	NM_018082	NP_060552	Q9NW08	RPC2_HUMAN	DNA-directed RNA polymerase III B isoform 1	372					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			ovary(1)|central_nervous_system(1)	2						TTTATCTCTTCTTTTTGAAGA	0.274		NaN											0	0	0	0.00308	0	6	19									
MVK	4598	broad.mit.edu	37	12	110024578	110024578	+	Silent	SNP	T	T	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:110024578T>C	uc001toy.3	+	7	835	c.651T>C	c.(649-651)CAT>CAC	p.H217H	MVK_uc009zvk.2_Silent_p.H217H|MVK_uc010sxr.1_Silent_p.H165H|MVK_uc001toz.3_Silent_p.H23H|MVK_uc001tpc.3_RNA	NM_001114185	NP_001107657	Q03426	KIME_HUMAN	mevalonate kinase	217					cholesterol biosynthetic process|isoprenoid biosynthetic process	cytosol|peroxisome	ATP binding|identical protein binding|mevalonate kinase activity				0						TCCGATACCATCAAGGGAAGA	0.507		NaN											0	0	0	0.00308	0	7	124									
C12orf43	64897	broad.mit.edu	37	12	121454205	121454205	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:121454205G>C	uc001tzh.1	-	1	96	c.73C>G	c.(73-75)CGG>GGG	p.R25G	C12orf43_uc009zxa.1_Missense_Mutation_p.R25G|C12orf43_uc010szo.1_5'UTR|C12orf43_uc010szp.1_Missense_Mutation_p.R25G|C12orf43_uc001tzi.1_Missense_Mutation_p.R25G	NM_022895	NP_075046	Q96C57	CL043_HUMAN	hypothetical protein LOC64897	25											0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					TCGCGGCACCGCTCCAGCTCC	0.622		NaN											0	0	0	0.001168	0	5	74									
RNF34	80196	broad.mit.edu	37	12	121867872	121867872	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:121867872G>C	uc001uam.1	+	7	1213	c.1099G>C	c.(1099-1101)GAA>CAA	p.E367Q	KDM2B_uc001uaq.2_3'UTR|KDM2B_uc010szy.1_3'UTR|KDM2B_uc001uar.2_3'UTR|KDM2B_uc001uas.2_3'UTR|KDM2B_uc001uat.2_3'UTR|KDM2B_uc001uau.2_3'UTR|KDM2B_uc001uao.2_3'UTR|KDM2B_uc010szx.1_3'UTR|KDM2B_uc001uap.2_RNA	NM_025126	NP_079402	Q969K3	RNF34_HUMAN	ring finger protein 34 isoform 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					apoptosis	endomembrane system|membrane|nuclear speck	ligase activity|zinc ion binding				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000432)|Epithelial(86;0.00233)		AAATGGTCCAGAAAGCAGTGC	0.483		NaN											0	0	0	0.001855	0	12	59									
ULK1	8408	broad.mit.edu	37	12	132403850	132403850	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:132403850G>A	uc001uje.2	+	24	2873	c.2605G>A	c.(2605-2607)GAG>AAG	p.E869K		NM_003565	NP_003556	O75385	ULK1_HUMAN	Unc-51-like kinase 1	869					autophagy|protein localization|regulation of autophagy	autophagic vacuole|cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	ATP binding|protein complex binding|protein serine/threonine kinase activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.07e-08)|Epithelial(86;2.56e-07)|all cancers(50;3.01e-07)		CAGCGCCAGTGAGGCGGCGGG	0.682		NaN											0	0	0	0.003163	0	14	33									
PUS1	80324	broad.mit.edu	37	12	132426135	132426135	+	Silent	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:132426135G>C	uc001ujf.2	+	5	1322	c.843G>C	c.(841-843)GTG>GTC	p.V281V	PUS1_uc001ujg.2_Silent_p.V253V|PUS1_uc001ujh.2_Silent_p.V253V|PUS1_uc001uji.2_Silent_p.V228V	NM_025215	NP_079491	Q9Y606	TRUA_HUMAN	pseudouridine synthase 1 isoform 1	281						mitochondrion	pseudouridine synthase activity|pseudouridylate synthase activity|RNA binding			breast(1)|central_nervous_system(1)	2	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.05e-08)|Epithelial(86;2.51e-07)|all cancers(50;2.94e-07)		AGTTTGCGGTGATCAGGGTGA	0.607		NaN											0	0	0	0.01441	0	60	56									
PUS1	80324	broad.mit.edu	37	12	132426465	132426465	+	Silent	SNP	G	G	C	rs142637371		TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:132426465G>C	uc001ujf.2	+	5	1652	c.1173G>C	c.(1171-1173)CTG>CTC	p.L391L	PUS1_uc001ujg.2_Silent_p.L363L|PUS1_uc001ujh.2_Silent_p.L363L|PUS1_uc001uji.2_Silent_p.L338L	NM_025215	NP_079491	Q9Y606	TRUA_HUMAN	pseudouridine synthase 1 isoform 1	391						mitochondrion	pseudouridine synthase activity|pseudouridylate synthase activity|RNA binding			breast(1)|central_nervous_system(1)	2	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.05e-08)|Epithelial(86;2.51e-07)|all cancers(50;2.94e-07)		CCCAGTGGCTGAGCACCTTGC	0.637		NaN											0	0	0	0.012213	0	33	24									
SKA3	221150	broad.mit.edu	37	13	21736001	21736001	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr13:21736001C>T	uc001unt.2	-	5	851	c.757G>A	c.(757-759)GAT>AAT	p.D253N	SKA3_uc001unv.2_Missense_Mutation_p.D171N|SKA3_uc001unu.2_Missense_Mutation_p.D253N	NM_145061	NP_659498	Q8IX90	SKA3_HUMAN	SKA3	253					cell division|chromosome segregation|mitosis|regulation of microtubule polymerization or depolymerization	condensed chromosome outer kinetochore|cytoplasm|spindle microtubule	protein binding				0						GATTCTGTATCTATGGCCTCC	0.363		NaN											0	0	0	0.001984	0	6	15									
FAM48A	55578	broad.mit.edu	37	13	37584737	37584737	+	Silent	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr13:37584737C>T	uc001uwg.2	-	25	2402	c.2154G>A	c.(2152-2154)CAG>CAA	p.Q718Q	FAM48A_uc010abt.2_Intron|FAM48A_uc001uwh.2_Intron|FAM48A_uc001uwi.2_Intron|FAM48A_uc001uwj.2_Intron|FAM48A_uc001uwk.2_Intron|FAM48A_uc001uwd.2_Intron|FAM48A_uc001uwe.2_Silent_p.Q202Q|FAM48A_uc001uwf.2_Silent_p.Q284Q	NM_001014286	NP_001014308	Q8NEM7	FA48A_HUMAN	family with sequence similarity 48, member A	718	Gln-rich.				autophagy|gastrulation	SAGA-type complex	protein binding				0		Lung NSC(96;2.09e-06)|Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.0959)		all cancers(112;6.06e-07)|Epithelial(112;1.87e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00794)|BRCA - Breast invasive adenocarcinoma(63;0.0128)|GBM - Glioblastoma multiforme(144;0.0477)		GCTGGAATCTCTGCTGAGGAA	0.463		NaN											0	0	0	0.00278	0	21	56									
DIS3	22894	broad.mit.edu	37	13	73334716	73334716	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr13:73334716G>A	uc001vix.3	-	20	3118	c.2744C>T	c.(2743-2745)TCA>TTA	p.S915L	DIS3_uc001viy.3_Missense_Mutation_p.S885L|DIS3_uc001viz.2_RNA	NM_014953	NP_055768	Q9Y2L1	RRP44_HUMAN	DIS3 mitotic control isoform a	915					CUT catabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA catabolic process|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|nucleoplasm	3'-5'-exoribonuclease activity|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|RNA binding			central_nervous_system(1)	1		Breast(118;0.0074)|Acute lymphoblastic leukemia(28;0.0195)		GBM - Glioblastoma multiforme(99;0.000181)		AAGATTAGATGAGTCTAACAT	0.328		NaN								Multiple Myeloma(4;0.011)			0	0	0	0.01441	0	53	36									
TPP2	7174	broad.mit.edu	37	13	103301811	103301811	+	Nonsense_Mutation	SNP	C	C	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr13:103301811C>G	uc001vpi.3	+	23	3030	c.2927C>G	c.(2926-2928)TCA>TGA	p.S976*		NM_003291	NP_003282	P29144	TPP2_HUMAN	tripeptidyl peptidase II	976					proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TTAACATTGTCAAAGACTGAA	0.303		NaN											0	0	0	0.004007	0	12	72									
ARHGEF7	8874	broad.mit.edu	37	13	111932947	111932947	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr13:111932947G>C	uc001vrs.2	+	16	1961	c.1711G>C	c.(1711-1713)GAG>CAG	p.E571Q	ARHGEF7_uc001vrr.2_Missense_Mutation_p.E550Q|ARHGEF7_uc001vrt.2_Missense_Mutation_p.E521Q|ARHGEF7_uc010tjn.1_RNA|ARHGEF7_uc001vru.1_Missense_Mutation_p.E393Q|ARHGEF7_uc001vrv.3_Missense_Mutation_p.E393Q|ARHGEF7_uc001vrw.3_Missense_Mutation_p.E393Q|ARHGEF7_uc001vrx.3_Missense_Mutation_p.E393Q|ARHGEF7_uc010tjo.1_Missense_Mutation_p.E468Q|ARHGEF7_uc010tjp.1_Missense_Mutation_p.E315Q|ARHGEF7_uc001vry.1_5'Flank	NM_001113511	NP_001106983	Q14155	ARHG7_HUMAN	PAK-interacting exchange factor beta isoform c	571	PH.				apoptosis|epidermal growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_lung(23;3.96e-05)|Lung NSC(43;0.00156)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.188)			GGAATGGGTGGAGCACCTACA	0.498		NaN											0	0	0	0.01441	0	75	78									
OR10G2	26534	broad.mit.edu	37	14	22102290	22102290	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr14:22102290C>A	uc010tmc.1	-	1	709	c.709G>T	c.(709-711)GAT>TAT	p.D237Y		NM_001005466	NP_001005466	Q8NGC3	O10G2_HUMAN	olfactory receptor, family 10, subfamily G,	237	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0142)		CGCCTCCCATCAGCGGTGCGT	0.542		NaN											1	0	7.45023e-12	0.010504	7.9146e-12	21	24									
OR10G2	26534	broad.mit.edu	37	14	22102306	22102306	+	Silent	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr14:22102306C>T	uc010tmc.1	-	1	693	c.693G>A	c.(691-693)CTG>CTA	p.L231L		NM_001005466	NP_001005466	Q8NGC3	O10G2_HUMAN	olfactory receptor, family 10, subfamily G,	231	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0142)		TGCGTATCTTCAGGATGGCAT	0.532		NaN											0	0	0	0.006122	0	18	24									
PSMB5	5693	broad.mit.edu	37	14	23502856	23502856	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr14:23502856C>G	uc001wii.2	-	2	490	c.226G>C	c.(226-228)GAC>CAC	p.D76H	PSMB5_uc001wij.2_Missense_Mutation_p.D76H|PSMB5_uc010tni.1_5'UTR	NM_002797	NP_002788	P28074	PSB5_HUMAN	proteasome beta 5 subunit isoform 1	76					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus	protein binding|threonine-type endopeptidase activity			ovary(1)	1	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.0121)	Bortezomib(DB00188)	GCCCTGGAGTCAGCTGCAACT	0.507		NaN											0	0	0	0.003163	0	14	27									
INSM2	84684	broad.mit.edu	37	14	36005008	36005008	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr14:36005008C>G	uc001wth.1	+	1	1761	c.1550C>G	c.(1549-1551)TCT>TGT	p.S517C		NM_032594	NP_115983	Q96T92	INSM2_HUMAN	insulinoma-associated protein IA-6	517					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			lung(1)|skin(1)	2	Breast(36;0.122)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(9;2.16e-07)|Lung(238;2.63e-07)|Epithelial(34;0.00145)|all cancers(34;0.00452)	GBM - Glioblastoma multiforme(112;0.0223)		AGCGGGCCATCTGACGGGAGT	0.627		NaN											0	0	0	0.010729	0	12	22									
HIF1A	3091	broad.mit.edu	37	14	62207727	62207727	+	Silent	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr14:62207727G>A	uc001xfq.2	+	12	2318	c.1914G>A	c.(1912-1914)TTG>TTA	p.L638L	HIF1A_uc001xfr.2_Silent_p.L638L|HIF1A_uc001xfs.2_Silent_p.L639L	NM_001530	NP_001521	Q16665	HIF1A_HUMAN	hypoxia-inducible factor 1, alpha subunit	638	ID.				cellular response to hypoxia|collagen metabolic process|connective tissue replacement involved in inflammatory response wound healing|elastin metabolic process|epithelial to mesenchymal transition|oxygen homeostasis|positive regulation of chemokine production|positive regulation of epithelial cell migration|positive regulation of hormone biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|regulation of transforming growth factor-beta2 production	cytoplasm|nucleolus|transcription factor complex	histone acetyltransferase binding|Hsp90 protein binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			kidney(3)|lung(1)	4				OV - Ovarian serous cystadenocarcinoma(108;1.62e-09)|BRCA - Breast invasive adenocarcinoma(234;0.189)		TTAAAATATTGATTGCATCTC	0.408		NaN											0	0	0	0.005443	0	27	28									
CYP46A1	10858	broad.mit.edu	37	14	100157465	100157465	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr14:100157465G>A	uc001ygo.2	+	2	167	c.167G>A	c.(166-168)GGT>GAT	p.G56D	CYP46A1_uc001ygn.1_Missense_Mutation_p.V4M	NM_006668	NP_006659	Q9Y6A2	CP46A_HUMAN	cytochrome P450, family 46	56					bile acid biosynthetic process|cholesterol catabolic process|nervous system development|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol 24-hydroxylase activity|electron carrier activity|heme binding|steroid hydroxylase activity				0		Melanoma(154;0.0866)|all_epithelial(191;0.179)				GATGAGGTTGGTGGCCGTGTG	0.493		NaN											0	0	0	0.010771	0	38	66									
GCHFR	2644	broad.mit.edu	37	15	41056393	41056393	+	Silent	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr15:41056393C>T	uc001zmr.1	+	1	109	c.15C>T	c.(13-15)CTC>CTT	p.L5L	GCHFR_uc010ucr.1_Silent_p.L5L	NM_005258	NP_005249	P30047	GFRP_HUMAN	GTP cyclohydrolase I feedback regulatory	5					negative regulation of biosynthetic process|neurotransmitter metabolic process|nitric oxide biosynthetic process	cytosol|dendrite|melanosome|nuclear membrane				ovary(1)	1		all_cancers(109;3.3e-18)|all_epithelial(112;2.33e-15)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.58e-05)|COAD - Colon adenocarcinoma(120;0.149)|BRCA - Breast invasive adenocarcinoma(123;0.163)		CCTACCTGCTCATCAGCACCC	0.701		NaN											0	0	0	0.009096	0	4	1									
GCHFR	2644	broad.mit.edu	37	15	41056396	41056396	+	Silent	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr15:41056396C>T	uc001zmr.1	+	1	112	c.18C>T	c.(16-18)ATC>ATT	p.I6I	GCHFR_uc010ucr.1_Silent_p.I6I	NM_005258	NP_005249	P30047	GFRP_HUMAN	GTP cyclohydrolase I feedback regulatory	6					negative regulation of biosynthetic process|neurotransmitter metabolic process|nitric oxide biosynthetic process	cytosol|dendrite|melanosome|nuclear membrane				ovary(1)	1		all_cancers(109;3.3e-18)|all_epithelial(112;2.33e-15)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.58e-05)|COAD - Colon adenocarcinoma(120;0.149)|BRCA - Breast invasive adenocarcinoma(123;0.163)		ACCTGCTCATCAGCACCCAGA	0.701		NaN											0	0	0	0.000602	0	5	1									
UNC13C	440279	broad.mit.edu	37	15	54630580	54630580	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr15:54630580C>T	uc002ack.2	+	15	4606	c.4606C>T	c.(4606-4608)CCA>TCA	p.P1536S	UNC13C_uc002acl.2_Missense_Mutation_p.P366S	NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1536					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GCAAAGCCCCCCAAAAGCGAG	0.403		NaN											0	0	0	0.01441	0	53	35									
RNF111	54778	broad.mit.edu	37	15	59350651	59350651	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr15:59350651C>T	uc002afv.2	+	5	1547	c.1268C>T	c.(1267-1269)TCT>TTT	p.S423F	RNF111_uc002afs.2_Missense_Mutation_p.S423F|RNF111_uc002aft.2_Missense_Mutation_p.S423F|RNF111_uc002afu.2_Missense_Mutation_p.S423F|RNF111_uc002afw.2_Missense_Mutation_p.S423F	NM_017610	NP_060080	Q6ZNA4	RN111_HUMAN	ring finger protein 111	423	Ser-rich.				multicellular organismal development|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2				all cancers(107;0.194)		GAGCAGGCCTCTGATACTGCT	0.458		NaN											0	0	0	0.01441	0	154	113									
RNF111	54778	broad.mit.edu	37	15	59350705	59350705	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr15:59350705C>T	uc002afv.2	+	5	1601	c.1322C>T	c.(1321-1323)TCA>TTA	p.S441L	RNF111_uc002afs.2_Missense_Mutation_p.S441L|RNF111_uc002aft.2_Missense_Mutation_p.S441L|RNF111_uc002afu.2_Missense_Mutation_p.S441L|RNF111_uc002afw.2_Missense_Mutation_p.S441L	NM_017610	NP_060080	Q6ZNA4	RN111_HUMAN	ring finger protein 111	441	Ser-rich.				multicellular organismal development|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2				all cancers(107;0.194)		TCAGAGACTTCAGCTACTCTT	0.448		NaN											0	0	0	0.01441	0	129	112									
RNF111	54778	broad.mit.edu	37	15	59350741	59350741	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr15:59350741C>G	uc002afv.2	+	5	1637	c.1358C>G	c.(1357-1359)TCT>TGT	p.S453C	RNF111_uc002afs.2_Missense_Mutation_p.S453C|RNF111_uc002aft.2_Missense_Mutation_p.S453C|RNF111_uc002afu.2_Missense_Mutation_p.S453C|RNF111_uc002afw.2_Missense_Mutation_p.S453C	NM_017610	NP_060080	Q6ZNA4	RN111_HUMAN	ring finger protein 111	453	Ser-rich.				multicellular organismal development|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2				all cancers(107;0.194)		ACTGGCACTTCTATAGGAGGT	0.413		NaN											0	0	0	0.01441	0	118	78									
AGBL1	123624	broad.mit.edu	37	15	86790936	86790936	+	Silent	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr15:86790936C>T	uc002blz.1	+	6	503	c.423C>T	c.(421-423)TAC>TAT	p.Y141Y		NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	141					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						ACCGAGGCTACGTCACCAGCC	0.592		NaN											0	0	0	0.006214	0	10	8									
UBN1	29855	broad.mit.edu	37	16	4908646	4908646	+	Silent	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr16:4908646C>T	uc002cyb.2	+	4	753	c.414C>T	c.(412-414)TTC>TTT	p.F138F	UBN1_uc010uxw.1_Silent_p.F138F|UBN1_uc002cyc.2_Silent_p.F138F	NM_001079514	NP_001072982	Q9NPG3	UBN1_HUMAN	ubinuclein 1	138	Sufficient for interaction with HIRA.			F->E: Strongly diminishes interaction with HIRA; when associated with E-139 and L-140.	chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2						CCGACTCCTTCATCGATAACT	0.463		NaN											0	0	0	0.006214	0	10	16									
INO80E	283899	broad.mit.edu	37	16	30007659	30007659	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr16:30007659G>C	uc002dvg.1	+	1	129	c.28G>C	c.(28-30)GAC>CAC	p.D10H	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|INO80E_uc002dvh.1_RNA|INO80E_uc002dvi.1_Missense_Mutation_p.D10H|INO80E_uc002dvj.1_RNA|INO80E_uc002dvk.1_Missense_Mutation_p.D10H|HIRIP3_uc002dve.2_5'Flank|HIRIP3_uc002dvf.2_5'Flank	NM_173618	NP_775889	Q8NBZ0	IN80E_HUMAN	INO80 complex subunit E	10	Potential.				DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex				skin(1)	1						CGGCGAAGTGGACTACAAAAA	0.652		NaN											0	0	0	0.001168	0	5	10									
TPPP3	51673	broad.mit.edu	37	16	67424463	67424463	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr16:67424463G>C	uc002esz.2	-	2	1096	c.261C>G	c.(259-261)TTC>TTG	p.F87L	TPPP3_uc002eta.2_Missense_Mutation_p.F87L|TPPP3_uc002etb.2_Missense_Mutation_p.F87L	NM_016140	NP_057224	Q9BW30	TPPP3_HUMAN	tubulin polymerization-promoting protein family	87					microtubule bundle formation	cytoplasm|microtubule	calcium ion binding|tubulin binding			central_nervous_system(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0336)|Epithelial(162;0.0781)		TCTTCCCCTTGAATCTCTTGG	0.582		NaN											0	0	0	0.01441	0	158	88									
SLC12A4	6560	broad.mit.edu	37	16	67986272	67986272	+	Silent	SNP	C	C	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr16:67986272C>A	uc002euz.2	-	7	873	c.732G>T	c.(730-732)TCG>TCT	p.S244S	SLC12A4_uc010ceu.2_Silent_p.S238S|SLC12A4_uc010vkh.1_Silent_p.S213S|SLC12A4_uc010vki.1_Silent_p.S244S|SLC12A4_uc010vkj.1_Silent_p.S246S|SLC12A4_uc002eva.2_Silent_p.S244S|SLC12A4_uc002evb.2_RNA|SLC12A4_uc010cew.1_Missense_Mutation_p.R166L	NM_005072	NP_005063	Q9UP95	S12A4_HUMAN	solute carrier family 12, member 4 isoform a	244					cell volume homeostasis|potassium ion transport|sodium ion transport	integral to plasma membrane|membrane fraction	potassium:chloride symporter activity			ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	AAGTGGCATTCGACGTGTCAT	0.453		NaN											1	0	1.32136e-16	0.00874	1.41522e-16	44	16									
COG8	84342	broad.mit.edu	37	16	69373430	69373430	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr16:69373430G>A	uc002ewy.2	-	1	97	c.26C>T	c.(25-27)TCG>TTG	p.S9L	COG8_uc002ewz.3_Missense_Mutation_p.S9L|NIP7_uc002exa.2_5'Flank|NIP7_uc002exb.2_5'Flank	NM_032382	NP_115758	Q96MW5	COG8_HUMAN	component of oligomeric golgi complex 8	9					protein transport	Golgi membrane|Golgi transport complex				ovary(1)	1						CGTGGCTACCGATGGGATAGT	0.652		NaN									OREG0023907	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008871	0	19	4									
ZC3H18	124245	broad.mit.edu	37	16	88677707	88677707	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr16:88677707G>A	uc002fky.2	+	8	1438	c.1238G>A	c.(1237-1239)AGA>AAA	p.R413K	ZC3H18_uc010voy.1_Missense_Mutation_p.R296K|ZC3H18_uc010voz.1_Missense_Mutation_p.R437K|ZC3H18_uc010chw.2_RNA	NM_144604	NP_653205	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	413	Potential.					nucleus	nucleic acid binding|zinc ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0542)		agagagaacagacagcgcgag	0		NaN											0	0	0	0.010504	0	22	6									
TUBB3	10381	broad.mit.edu	37	16	90001896	90001896	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr16:90001896C>T	uc002fph.1	+	4	1102	c.1037C>T	c.(1036-1038)CCC>CTC	p.P346L	TUBB3_uc002fpf.2_Missense_Mutation_p.P693L|TUBB3_uc010ciz.1_Missense_Mutation_p.P274L|TUBB3_uc002fpg.1_Missense_Mutation_p.P200L|TUBB3_uc002fpi.1_Missense_Mutation_p.P274L|TUBB3_uc002fpj.1_Missense_Mutation_p.P274L|TUBB3_uc010cjb.1_Missense_Mutation_p.P200L|TUBB3_uc002fpk.1_Missense_Mutation_p.P200L	NM_006086	NP_006077	Q13509	TBB3_HUMAN	tubulin, beta, 4	346					'de novo' posttranslational protein folding|axon guidance|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(2)|pancreas(1)	3		all_cancers(9;1.69e-11)|Lung NSC(15;8.94e-06)|all_lung(18;1.39e-05)|all_neural(9;0.00581)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		GAGTGGATCCCCAACAACGTG	0.612		NaN											0	0	0	0.01441	0	139	60									
SMYD4	114826	broad.mit.edu	37	17	1703353	1703353	+	Silent	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:1703353G>C	uc002ftm.3	-	5	1503	c.1335C>G	c.(1333-1335)CTC>CTG	p.L445L	SMYD4_uc002ftn.1_Silent_p.L300L	NM_052928	NP_443160	Q8IYR2	SMYD4_HUMAN	SET and MYND domain containing 4	445							zinc ion binding			skin(3)|kidney(2)	5						CAGAAACACAGAGAGCACAGA	0.453		NaN											0	0	0	0.004289	0	38	33									
ATP1B2	482	broad.mit.edu	37	17	7554879	7554879	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:7554879G>C	uc002gif.1	+	1	626	c.43G>C	c.(43-45)GAG>CAG	p.E15Q		NM_001678	NP_001669	P14415	AT1B2_HUMAN	Na+/K+ -ATPase beta 2 subunit	15	Cytoplasmic (Potential).				ATP biosynthetic process|blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|sodium:potassium-exchanging ATPase activity	p.0?(2)|p.?(1)		central_nervous_system(1)|pancreas(1)	2		all_cancers(10;0.000178)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;2.55e-06)|READ - Rectum adenocarcinoma(115;0.168)		GCAGGTGGTTGAGGAGTGGAA	0.697		NaN											0	0	0	0.004672	0	2	6									
ALOXE3	59344	broad.mit.edu	37	17	8018956	8018956	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:8018956G>A	uc010cnr.2	-	4	773	c.403C>T	c.(403-405)CGG>TGG	p.R135W	ALOXE3_uc002gka.2_Missense_Mutation_p.R291W|ALOXE3_uc010vuo.1_Missense_Mutation_p.R267W|ALOXE3_uc010vup.1_RNA	NM_021628	NP_067641	Q9BYJ1	LOXE3_HUMAN	arachidonate lipoxygenase 3 isoform 2	135	Lipoxygenase.				leukotriene biosynthetic process		iron ion binding|lipoxygenase activity			skin(3)|lung(1)|central_nervous_system(1)	5						CGGAGCTCCCGTGTCCTGTGA	0.473		NaN											0	0	0	0.007835	0	36	26									
NTN1	9423	broad.mit.edu	37	17	8926345	8926345	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:8926345G>A	uc002glw.3	+	2	762	c.655G>A	c.(655-657)GCC>ACC	p.A219T		NM_004822	NP_004813	O95631	NET1_HUMAN	netrin 1 precursor	219	Laminin N-terminal.				apoptosis|axon guidance		protein binding				0						CGGCCTCATCGCCTTCAGCAC	0.701		NaN											0	0	0	0.000602	0	5	8									
TRPV2	51393	broad.mit.edu	37	17	16327060	16327060	+	Silent	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:16327060C>T	uc002gpy.2	+	5	1270	c.903C>T	c.(901-903)GCC>GCT	p.A301A	TRPV2_uc002gpz.2_Intron	NM_016113	NP_057197	Q9Y5S1	TRPV2_HUMAN	transient receptor potential cation channel,	301	Cytoplasmic (Potential).|Required for interaction with SLC50A1 (By similarity).|ANK 6.				sensory perception	integral to plasma membrane|melanosome	calcium channel activity			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		TGAAGCTGGCCGCCAAGGAGG	0.597		NaN											0	0	0	0.00499	0	16	17									
PLD6	201164	broad.mit.edu	37	17	17109483	17109483	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:17109483C>T	uc002gqz.2	-	1	150	c.118G>A	c.(118-120)GAG>AAG	p.E40K	PLD6_uc010cpn.2_Intron	NM_178836	NP_849158	Q8N2A8	PLD6_HUMAN	phospholipase D6	40	Cytoplasmic (Potential).				DNA methylation involved in gamete generation|lipid catabolic process|meiosis|mitochondrial fusion|P granule organization|piRNA metabolic process|spermatid development	integral to membrane|mitochondrial outer membrane	cardiolipin hydrolase activity|protein homodimerization activity				0						AACAGCGCCTcgcgccgcggc	0.667		NaN											0	0	0	0.000602	0	5	3									
MLLT6	4302	broad.mit.edu	37	17	36863784	36863784	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:36863784G>A	uc002hqi.3	+	3	248	c.235G>A	c.(235-237)GAT>AAT	p.D79N	MLLT6_uc010wdr.1_Missense_Mutation_p.D79N|MLLT6_uc010cvm.1_Missense_Mutation_p.D79N	NM_005937	NP_005928	P55198	AF17_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	79					regulation of transcription, DNA-dependent	nucleus	protein binding|zinc ion binding			breast(3)|prostate(1)|lung(1)|skin(1)	6	Breast(7;4.43e-21)					GAAGAGGACTGATAATGGAGG	0.612		NaN	T	MLL	AL								0	0	0	0.010504	0	19	90									
CACNB1	782	broad.mit.edu	37	17	37331640	37331640	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:37331640G>A	uc002hrm.1	-	14	1756	c.1603C>T	c.(1603-1605)CCT>TCT	p.P535S	CACNB1_uc002hrl.1_Missense_Mutation_p.P307S	NM_000723	NP_000714	Q02641	CACB1_HUMAN	calcium channel, voltage-dependent, beta 1	535					axon guidance	voltage-gated calcium channel complex				large_intestine(1)|ovary(1)	2					Ibutilide(DB00308)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Verapamil(DB00661)	CCCCCTGCAGGGTCTCCAAGC	0.657		NaN									OREG0024371	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	66	357									
MED1	5469	broad.mit.edu	37	17	37564338	37564338	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:37564338G>A	uc002hrv.3	-	17	4348	c.4136C>T	c.(4135-4137)TCA>TTA	p.S1379L	MED1_uc010wee.1_Missense_Mutation_p.S1207L|MED1_uc002hru.2_Intron	NM_004774	NP_004765	Q15648	MED1_HUMAN	mediator complex subunit 1	1379	Ser-rich.|Interaction with TP53.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			lung(2)|ovary(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	8		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		TTTTGACTCTGAGGTCTTCTT	0.443		NaN								HNSCC(31;0.082)			0	0	0	0.01441	0	52	76									
MED1	5469	broad.mit.edu	37	17	37564821	37564821	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:37564821G>C	uc002hrv.3	-	17	3865	c.3653C>G	c.(3652-3654)TCC>TGC	p.S1218C	MED1_uc010wee.1_Missense_Mutation_p.S1046C|MED1_uc002hru.2_Intron	NM_004774	NP_004765	Q15648	MED1_HUMAN	mediator complex subunit 1	1218	Ser-rich.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			lung(2)|ovary(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	8		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		GGCTTTAGAGGATGGAGGAGT	0.478		NaN								HNSCC(31;0.082)			0	0	0	0.005524	0	38	30									
DCAKD	79877	broad.mit.edu	37	17	43112207	43112207	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:43112207G>A	uc002ihx.2	-	1	303	c.47C>T	c.(46-48)TCA>TTA	p.S16L	DCAKD_uc010daa.1_Missense_Mutation_p.S16L|DCAKD_uc010dab.1_Missense_Mutation_p.S16L|DCAKD_uc002ihy.2_Missense_Mutation_p.S16L	NM_024819	NP_079095	Q8WVC6	DCAKD_HUMAN	dephospho-CoA kinase domain containing	16	DPCK.				coenzyme A biosynthetic process		ATP binding|dephospho-CoA kinase activity				0		Prostate(33;0.155)				CTGGATCACTGAGCTCTTGCC	0.612		NaN											0	0	0	0.004482	0	8	46									
CDC27	996	broad.mit.edu	37	17	45199920	45199920	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:45199920G>A	uc002ild.3	-	18	2409	c.2282C>T	c.(2281-2283)TCT>TTT	p.S761F	CDC27_uc002ile.3_Missense_Mutation_p.S767F|CDC27_uc002ilf.3_Missense_Mutation_p.S760F|CDC27_uc010wkp.1_Missense_Mutation_p.S700F|CDC27_uc010wkq.1_RNA	NM_001256	NP_001247	P30260	CDC27_HUMAN	cell division cycle protein 27 isoform 2	761	TPR 9.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			lung(2)|breast(2)|ovary(1)	5						CATAGCCCAAGAGAAATTCAT	0.383		NaN											0	0	0	0.012213	0	34	38									
DLX3	1747	broad.mit.edu	37	17	48068882	48068882	+	Silent	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:48068882C>T	uc002ipy.2	-	3	1089	c.863G>A	c.(862-864)TGA>TAA	p.*288*		NM_005220	NP_005211	O60479	DLX3_HUMAN	distal-less homeobox 3	288						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GATGGGTGCTCAGTACACAGC	0.642		NaN											0	0	0	0.000602	0	5	26									
TOB1	10140	broad.mit.edu	37	17	48940478	48940478	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:48940478G>A	uc002isw.2	-	1	936	c.901C>T	c.(901-903)CTC>TTC	p.L301F	TOB1_uc010wmy.1_Missense_Mutation_p.L301F|TOB1_uc010wmz.1_Missense_Mutation_p.L301F	NM_005749	NP_005740	P50616	TOB1_HUMAN	transducer of ERBB2, 1	301					negative regulation of cell proliferation		SH3/SH2 adaptor activity			large_intestine(1)	1			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			CTGTACTGGAGAGGACTGAGG	0.413		NaN											0	0	0	0.01441	0	43	47									
NME1-NME2	654364	broad.mit.edu	37	17	49231768	49231768	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:49231768C>T	uc002itk.2	+	2	287	c.34C>T	c.(34-36)CAA>TAA	p.Q12*	NME1_uc010dbx.1_Nonsense_Mutation_p.Q12*|NME1_uc002ith.1_Nonsense_Mutation_p.Q12*|NME1_uc002iti.1_Intron|NME1-NME2_uc002itj.2_Intron	NM_002512	NP_002503	P22392	NDKB_HUMAN	nucleoside diphosphate kinase B	Error:Variant_position_missing_in_P22392_after_alignment					cell adhesion|CTP biosynthetic process|GTP biosynthetic process|negative regulation of apoptosis|nucleobase, nucleoside and nucleotide interconversion|positive regulation of epithelial cell proliferation|positive regulation of keratinocyte differentiation|UTP biosynthetic process	cytosol|lamellipodium|nucleus|ruffle	ATP binding|DNA binding|metal ion binding|nucleoside diphosphate kinase activity|protein binding|protein histidine kinase activity|sequence-specific DNA binding transcription factor activity				0			BRCA - Breast invasive adenocarcinoma(22;1.54e-08)			GATCGTCTTTCAAGGCGAGGG	0.308		NaN											0	0	0	0.003755	0	31	99									
VEZF1	7716	broad.mit.edu	37	17	56060115	56060115	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:56060115C>T	uc002ivf.1	-	2	816	c.673G>A	c.(673-675)GAA>AAA	p.E225K	VEZF1_uc010dcn.1_Missense_Mutation_p.E69K	NM_007146	NP_009077	Q14119	VEZF1_HUMAN	zinc finger protein 161	225					cellular defense response|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)	2						ATGCCTCCTTCATGAGACCTC	0.408		NaN											0	0	0	0.004007	0	16	100									
TBX2	6909	broad.mit.edu	37	17	59482604	59482604	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:59482604G>C	uc010wox.1	+	6	1374	c.1093G>C	c.(1093-1095)GAG>CAG	p.E365Q	TBX2_uc002ize.2_3'UTR|TBX2_uc002izg.2_Missense_Mutation_p.E211Q	NM_005994	NP_005985	Q13207	TBX2_HUMAN	T-box 2	365					cell aging|positive regulation of cell proliferation		sequence-specific DNA binding				0						CCCGGAGCCTGAGCGGTTGAG	0.741		NaN											0	0	0	0.000602	0	5	9									
DDX42	11325	broad.mit.edu	37	17	61895626	61895626	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:61895626G>C	uc002jbu.2	+	19	2942	c.2685G>C	c.(2683-2685)AAG>AAC	p.K895N	DDX42_uc002jbv.2_Missense_Mutation_p.K895N|DDX42_uc002jbx.2_Missense_Mutation_p.K631N|DDX42_uc002jby.2_Missense_Mutation_p.K441N|DDX42_uc010wps.1_Missense_Mutation_p.K263N	NM_007372	NP_031398	Q86XP3	DDX42_HUMAN	DEAD box polypeptide 42 protein	895					protein localization|regulation of anti-apoptosis	Cajal body|cytoplasm|nuclear speck	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)|large_intestine(1)	5						GTGAGAGCAAGATGGAGCCCA	0.547		NaN											0	0	0	0.006999	0	43	63									
GPRC5C	55890	broad.mit.edu	37	17	72436224	72436224	+	Silent	SNP	C	C	T	rs148101331		TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:72436224C>T	uc002jks.2	+	1	348	c.309C>T	c.(307-309)CTC>CTT	p.L103L	GPRC5C_uc002jkp.2_Silent_p.L148L|GPRC5C_uc002jkq.2_Intron|GPRC5C_uc002jkr.2_Silent_p.L115L|GPRC5C_uc002jkt.2_Silent_p.L103L|GPRC5C_uc002jku.2_5'Flank	NM_018653	NP_061123	Q9NQ84	GPC5C_HUMAN	G protein-coupled receptor family C, group 5,	103	Helical; Name=2; (Potential).					cytoplasmic vesicle membrane|integral to plasma membrane	G-protein coupled receptor activity|protein binding			ovary(2)|prostate(1)|central_nervous_system(1)|pancreas(1)	5						TCTTCTGCCTCGTGTTTGCCT	0.607		NaN											0	0	0	0.00623	0	38	69									
CASKIN2	57513	broad.mit.edu	37	17	73503147	73503147	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:73503147C>T	uc002joc.2	-	5	858	c.308G>A	c.(307-309)CGC>CAC	p.R103H	CASKIN2_uc010wsc.1_Missense_Mutation_p.R21H|CASKIN2_uc002jod.2_Missense_Mutation_p.R103H	NM_020753	NP_065804	Q8WXE0	CSKI2_HUMAN	cask-interacting protein 2 isoform a	103	ANK 2.					cytoplasm				pancreas(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CGCAGAGGCGCGCAGCAGCAG	0.662		NaN											0	0	0	0.00308	0	8	20									
UBE2O	63893	broad.mit.edu	37	17	74388108	74388108	+	Silent	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:74388108G>A	uc002jrm.3	-	16	3098	c.3033C>T	c.(3031-3033)ATC>ATT	p.I1011I	UBE2O_uc002jrl.3_Silent_p.I615I	NM_022066	NP_071349	Q9C0C9	UBE2O_HUMAN	ubiquitin-conjugating enzyme E2O	1011							ATP binding|ubiquitin-protein ligase activity			breast(2)|skin(2)|lung(1)	5						CGGCTGGGTAGATGTTGGGGA	0.592		NaN											0	0	0	0.00278	0	21	25									
CBX4	8535	broad.mit.edu	37	17	77808594	77808594	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:77808594C>A	uc002jxe.2	-	5	1010	c.847G>T	c.(847-849)GAG>TAG	p.E283*		NM_003655	NP_003646	O00257	CBX4_HUMAN	chromobox homolog 4	283	Interaction with BMI1.				anti-apoptosis|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|PcG protein complex	enzyme binding|transcription corepressor activity			skin(2)	2			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			TCTGCCACCTCGCCGGACTTG	0.592		NaN									OREG0024799	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	3.25985e-27	0.01441	3.53978e-27	75	103									
LPIN2	9663	broad.mit.edu	37	18	2925292	2925292	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr18:2925292G>A	uc002klo.2	-	14	2107	c.1868C>T	c.(1867-1869)CCC>CTC	p.P623L		NM_014646	NP_055461	Q92539	LPIN2_HUMAN	lipin 2	623					fatty acid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|triglyceride biosynthetic process	cytosol|endoplasmic reticulum membrane|nucleus	phosphatidate phosphatase activity|transcription coactivator activity			ovary(1)|skin(1)	2				READ - Rectum adenocarcinoma(2;0.0419)|Colorectal(6;0.156)		GGGCTCTGTGGGGATGGGGTC	0.547		NaN											0	0	0	0.003755	0	35	111									
MYO5B	4645	broad.mit.edu	37	18	47500848	47500848	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr18:47500848G>C	uc002leb.2	-	10	1482	c.1194C>G	c.(1192-1194)ATC>ATG	p.I398M	MYO5B_uc002lec.1_Missense_Mutation_p.I397M	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	398	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		TGCGCGCATTGATCACCTGCT	0.582		NaN											0	0	0	0.004656	0	27	29									
ZNF407	55628	broad.mit.edu	37	18	72347227	72347227	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr18:72347227G>C	uc002llw.2	+	1	4309	c.4252G>C	c.(4252-4254)GAT>CAT	p.D1418H	ZNF407_uc010xfc.1_Missense_Mutation_p.D1418H|ZNF407_uc010dqu.1_Missense_Mutation_p.D1418H|ZNF407_uc002llu.2_Missense_Mutation_p.D1417H	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	1418					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		TCGCTGTGATGATTGTGGCTT	0.438		NaN											0	0	0	0.004482	0	9	31									
SH3GL1	6455	broad.mit.edu	37	19	4363857	4363857	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:4363857C>T	uc002maj.2	-	6	590	c.484G>A	c.(484-486)GAG>AAG	p.E162K	SH3GL1_uc002mak.2_Missense_Mutation_p.E98K|SH3GL1_uc010xig.1_Missense_Mutation_p.E114K	NM_003025	NP_003016	Q99961	SH3G1_HUMAN	SH3-domain GRB2-like 1	162	Potential.|BAR.				central nervous system development|endocytosis|signal transduction	early endosome membrane	lipid binding|protein binding			ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0152)|STAD - Stomach adenocarcinoma(1328;0.182)		CGGCGGCCCTCCAGTTTCTTC	0.627		NaN	T	MLL	AL								0	0	0	0.003271	0	32	26									
SH3GL1	6455	broad.mit.edu	37	19	4364106	4364106	+	Silent	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:4364106C>T	uc002maj.2	-	5	550	c.444G>A	c.(442-444)GAG>GAA	p.E148E	SH3GL1_uc002mak.2_Silent_p.E84E|SH3GL1_uc010xig.1_Silent_p.E100E	NM_003025	NP_003016	Q99961	SH3G1_HUMAN	SH3-domain GRB2-like 1	148	Potential.|BAR.				central nervous system development|endocytosis|signal transduction	early endosome membrane	lipid binding|protein binding			ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0152)|STAD - Stomach adenocarcinoma(1328;0.182)		TCAGGTCTTTCTCGCACAGGT	0.632		NaN	T	MLL	AL								0	0	0	0.00333	0	23	15									
C19orf45	374877	broad.mit.edu	37	19	7565879	7565879	+	Silent	SNP	G	G	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:7565879G>T	uc002mgm.2	+	2	312	c.171G>T	c.(169-171)CCG>CCT	p.P57P		NM_198534	NP_940936	Q8NA69	CS045_HUMAN	hypothetical protein LOC374877	57											0						GGGAGCCGCCGAGCCTGCAGC	0.736		NaN											1	0	0.00198382	0.001984	0.00206275	7	7									
EVI5L	115704	broad.mit.edu	37	19	7928478	7928478	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:7928478G>A	uc002min.2	+	19	2429	c.2275G>A	c.(2275-2277)GAT>AAT	p.D759N	EVI5L_uc010xjz.1_Missense_Mutation_p.D770N	NM_145245	NP_660288	Q96CN4	EVI5L_HUMAN	ecotropic viral integration site 5-like isoform	759						intracellular	protein binding|Rab GTPase activator activity			ovary(1)	1						GTCCCCGCGCGATGCGCGCTT	0.687		NaN											0	0	0	0.010729	0	9	16									
ADAMTS10	81794	broad.mit.edu	37	19	8654126	8654126	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:8654126C>T	uc002mkj.1	-	18	2432	c.2158G>A	c.(2158-2160)GGG>AGG	p.G720R	ADAMTS10_uc002mki.1_Missense_Mutation_p.G207R|ADAMTS10_uc002mkk.1_Missense_Mutation_p.G352R	NM_030957	NP_112219	Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1	720	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			pancreas(2)|skin(2)	4						AGACTCTCACCGGCCCCAGGT	0.637		NaN											0	0	0	0.011902	0	40	38									
ADAMTS10	81794	broad.mit.edu	37	19	8654344	8654344	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:8654344C>T	uc002mkj.1	-	17	2300	c.2026G>A	c.(2026-2028)GAA>AAA	p.E676K	ADAMTS10_uc002mki.1_Missense_Mutation_p.E163K|ADAMTS10_uc002mkk.1_Missense_Mutation_p.E308K	NM_030957	NP_112219	Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1	676	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			pancreas(2)|skin(2)	4						ACCTTGCATTCGCCACTGACG	0.657		NaN											0	0	0	0.01441	0	95	84									
MUC16	94025	broad.mit.edu	37	19	9060229	9060229	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:9060229C>T	uc002mkp.2	-	3	27421	c.27217G>A	c.(27217-27219)GAA>AAA	p.E9073K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9075	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCTGTAGATTCTGTCTTGATG	0.488		NaN											0	0	0	0.01441	0	98	74									
ZNF846	162993	broad.mit.edu	37	19	9868197	9868197	+	Nonsense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:9868197G>C	uc002mmb.1	-	6	2087	c.1556C>G	c.(1555-1557)TCA>TGA	p.S519*	ZNF846_uc010xky.1_Intron|ZNF846_uc010xkz.1_Intron|ZNF846_uc010dww.2_Intron|ZNF846_uc002mmc.1_Nonsense_Mutation_p.S390*	NM_001077624	NP_001071092	Q147U1	ZN846_HUMAN	zinc finger protein 846	519	C2H2-type 14; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AGCAAGTGCTGAAGATTGAGT	0.368		NaN											0	0	0	0.010771	0	43	122									
PDE4A	5141	broad.mit.edu	37	19	10561309	10561309	+	Silent	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:10561309C>T	uc002moj.2	+	5	759	c.651C>T	c.(649-651)GTC>GTT	p.V217V	PDE4A_uc002mok.2_Silent_p.V191V|PDE4A_uc002mol.2_Silent_p.V156V|PDE4A_uc002mom.2_5'Flank|PDE4A_uc002mon.2_5'Flank	NM_001111307	NP_001104777	P27815	PDE4A_HUMAN	phosphodiesterase 4A isoform 1	217					signal transduction	cytosol|membrane fraction|perinuclear region of cytoplasm|ruffle membrane|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(20;5.8e-10)|Epithelial(33;7.58e-07)|all cancers(31;3.91e-06)		Cilostazol(DB01166)|Dipyridamole(DB00975)|Dyphylline(DB00651)|Enprofylline(DB00824)|Iloprost(DB01088)|Milrinone(DB00235)|Pentoxifylline(DB00806)|Phentolamine(DB00692)|Tadalafil(DB00820)|Theophylline(DB00277)	CCACCCCTGTCTGCAAGGCCA	0.672		NaN											0	0	0	0.013537	0	10	18									
SMARCA4	6597	broad.mit.edu	37	19	11151989	11151989	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:11151989G>A	uc002mqf.3	+	30	4461	c.4177G>A	c.(4177-4179)GAG>AAG	p.E1393K	SMARCA4_uc010dxp.2_Missense_Mutation_p.E1393K|SMARCA4_uc010dxo.2_Missense_Mutation_p.E1425K|SMARCA4_uc010dxq.2_Missense_Mutation_p.E1360K|SMARCA4_uc010dxr.2_Missense_Mutation_p.E1360K|SMARCA4_uc002mqj.3_Missense_Mutation_p.E1363K|SMARCA4_uc010dxs.2_Missense_Mutation_p.E1363K|SMARCA4_uc002mqh.3_Missense_Mutation_p.E483K	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	1393					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity			lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				GAAGGCCATCGAGGAGGGCAC	0.627		NaN	F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				0	0	0	0.01441	0	48	48									
ZNF799	90576	broad.mit.edu	37	19	12501795	12501795	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:12501795C>G	uc010dyt.2	-	4	1567	c.1417G>C	c.(1417-1419)GAG>CAG	p.E473Q	ZNF799_uc002mts.3_Intron	NM_001080821	NP_001074290	Q96GE5	ZN799_HUMAN	zinc finger protein 799	473					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|ovary(2)|skin(1)	6						TATGGCTTCTCTCCAGCATGA	0.383		NaN											0	0	0	0.01441	0	49	95									
AP1M1	8907	broad.mit.edu	37	19	16337279	16337279	+	Silent	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:16337279C>T	uc002ndu.2	+	6	767	c.594C>T	c.(592-594)ATC>ATT	p.I198I	AP1M1_uc002ndv.2_Silent_p.I210I|AP1M1_uc010xpd.1_Silent_p.I198I	NM_032493	NP_115882	Q9BXS5	AP1M1_HUMAN	adaptor-related protein complex 1, mu 1 subunit	198	MHD.				cellular membrane organization|endosome to melanosome transport|interspecies interaction between organisms|intracellular protein transport|melanosome organization|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding			ovary(3)|breast(1)	4						TGGGCTCCATCAAGATGCGAG	0.652		NaN											0	0	0	0.004482	0	9	4									
ZNF254	9534	broad.mit.edu	37	19	24309978	24309978	+	Silent	SNP	T	T	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:24309978T>C	uc002nru.2	+	4	1310	c.1176T>C	c.(1174-1176)ACT>ACC	p.T392T	ZNF254_uc010xrk.1_Silent_p.T307T	NM_203282	NP_975011	O75437	ZN254_HUMAN	zinc finger protein 254	392	C2H2-type 7.				negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				AACTCTCAACTCTTACTACAC	0.353		NaN											0	0	0	0.001855	0	5	49									
ZNF536	9745	broad.mit.edu	37	19	31039401	31039401	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:31039401C>G	uc002nsu.1	+	4	3013	c.2875C>G	c.(2875-2877)CCC>GCC	p.P959A	ZNF536_uc010edd.1_Missense_Mutation_p.P959A	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	959					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					TGAGGAGAAACCCAGTGGCAA	0.577		NaN											0	0	0	0.004482	0	9	185									
ARHGAP33	115703	broad.mit.edu	37	19	36279303	36279303	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:36279303C>T	uc002obs.1	+	21	3438	c.3353C>T	c.(3352-3354)TCT>TTT	p.S1118F	ARHGAP33_uc002obt.1_Missense_Mutation_p.S1115F|ARHGAP33_uc010eel.2_Intron|ARHGAP33_uc002obv.1_Missense_Mutation_p.S867F	NM_052948	NP_443180	O14559	RHG33_HUMAN	sorting nexin 26	1279					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			skin(2)|ovary(1)|pancreas(1)	4						TCCCTCCACTCTGAGGGCCAG	0.632		NaN											0	0	0	0.001168	0	6	7									
RYR1	6261	broad.mit.edu	37	19	38973699	38973699	+	Silent	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:38973699C>T	uc002oit.2	+	32	4783	c.4653C>T	c.(4651-4653)GTC>GTT	p.V1551V	RYR1_uc002oiu.2_Silent_p.V1551V	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	1551	Cytoplasmic.|B30.2/SPRY 3.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TTCCTGCCGTCTTCGTCCTGC	0.587		NaN											0	0	0	0.01441	0	81	76									
SAMD4B	55095	broad.mit.edu	37	19	39866385	39866385	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:39866385G>C	uc002olb.2	+	7	1798	c.763G>C	c.(763-765)GAG>CAG	p.E255Q	SAMD4B_uc002ola.2_Missense_Mutation_p.E255Q	NM_018028	NP_060498	Q5PRF9	SMAG2_HUMAN	sterile alpha motif domain containing 4B	255							protein binding				0	all_cancers(60;2.5e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			GAGTCCAGAGGAGCTTGGGGC	0.652		NaN											0	0	0	0.01441	0	166	173									
SAMD4B	55095	broad.mit.edu	37	19	39868175	39868175	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:39868175G>C	uc002olb.2	+	10	2190	c.1155G>C	c.(1153-1155)CAG>CAC	p.Q385H	SAMD4B_uc002ola.2_Missense_Mutation_p.Q385H	NM_018028	NP_060498	Q5PRF9	SMAG2_HUMAN	sterile alpha motif domain containing 4B	385							protein binding				0	all_cancers(60;2.5e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			AGCTGCAGCAGATCATCATCA	0.627		NaN											0	0	0	0.01441	0	49	72									
TMEM145	284339	broad.mit.edu	37	19	42827851	42827851	+	Silent	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:42827851C>T	uc002otk.1	+	14	1363	c.1311C>T	c.(1309-1311)TTC>TTT	p.F437F	MEGF8_uc002otl.3_5'Flank	NM_173633	NP_775904	Q8NBT3	TM145_HUMAN	transmembrane protein 145	437						integral to membrane					0		Prostate(69;0.00682)				ACAAGGCCTTCCCGCAGCACG	0.642		NaN											0	0	0	0.01441	0	56	75									
CEACAM8	1088	broad.mit.edu	37	19	43097978	43097978	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:43097978C>T	uc002oud.2	-	2	241	c.139G>A	c.(139-141)GAG>AAG	p.E47K	uc010eif.1_Intron|uc010eig.1_Intron|uc010eih.1_Intron	NM_001816	NP_001807	P31997	CEAM8_HUMAN	carcinoembryonic antigen-related cell adhesion	47	Ig-like V-type.				immune response	anchored to membrane|extracellular space|integral to plasma membrane				ovary(1)	1		Prostate(69;0.00899)				TCCTTCCCCTCTGCAGCATTG	0.537		NaN											0	0	0	0.01441	0	115	126									
PRKD2	25865	broad.mit.edu	37	19	47219391	47219391	+	Silent	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:47219391C>T	uc002pfh.2	-	2	579	c.237G>A	c.(235-237)CAG>CAA	p.Q79Q	PRKD2_uc002pfg.2_5'Flank|PRKD2_uc002pfi.2_Silent_p.Q79Q|PRKD2_uc002pfj.2_Silent_p.Q79Q|PRKD2_uc010xye.1_Silent_p.Q79Q|PRKD2_uc002pfk.2_5'UTR	NM_001079881	NP_001073350	Q9BZL6	KPCD2_HUMAN	protein kinase D2 isoform A	79					cell death|intracellular signal transduction|positive regulation of transcription from RNA polymerase II promoter|protein autophosphorylation|T cell receptor signaling pathway	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein kinase C activity			ovary(2)|central_nervous_system(2)|stomach(1)|large_intestine(1)|lung(1)	7		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000189)|all cancers(93;0.000545)|Epithelial(262;0.0219)|GBM - Glioblastoma multiforme(486;0.0353)		CCCTCACCTTCTGGTCCACGA	0.657		NaN											0	0	0	0.01441	0	50	43									
SCAF1	58506	broad.mit.edu	37	19	50155955	50155955	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:50155955G>A	uc002poq.2	+	7	2433	c.2309G>A	c.(2308-2310)CGG>CAG	p.R770Q		NM_021228	NP_067051	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	770	Ser-rich.				mRNA processing|RNA splicing	nucleus	RNA binding				0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		GGGTCTCGTCGGAAGGCGCTG	0.577		NaN											0	0	0	0.009096	0	4	5									
ZNF83	55769	broad.mit.edu	37	19	53116885	53116885	+	Silent	SNP	A	A	G	rs7247257		TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:53116885A>G	uc002pzu.3	-	2	2177	c.933T>C	c.(931-933)CAT>CAC	p.H311H	ZNF83_uc002pzv.3_Silent_p.H311H|ZNF83_uc010eps.2_Silent_p.H283H|ZNF83_uc010ept.2_Silent_p.H311H|ZNF83_uc010epu.2_Silent_p.H311H|ZNF83_uc010epv.2_Silent_p.H311H|ZNF83_uc010epw.2_Silent_p.H311H|ZNF83_uc010epx.2_Silent_p.H283H|ZNF83_uc010epy.2_Silent_p.H311H|ZNF83_uc010epz.2_Silent_p.H283H	NM_018300	NP_060770	P51522	ZNF83_HUMAN	zinc finger protein 83 isoform a	311	C2H2-type 8.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(262;0.00841)|GBM - Glioblastoma multiforme(134;0.0244)		TCTCTCCAGTATGAATTCTCC	0.418		NaN											0	0	0	0.004672	0	3	129									
LAIR1	3903	broad.mit.edu	37	19	54872615	54872615	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:54872615A>G	uc002qfk.1	-	3	582	c.272T>C	c.(271-273)GTA>GCA	p.V91A	LAIR1_uc002qfl.1_Missense_Mutation_p.V91A|LAIR1_uc002qfm.1_Missense_Mutation_p.V90A|LAIR1_uc002qfn.1_Missense_Mutation_p.V90A|LAIR1_uc010yex.1_Missense_Mutation_p.V84A|LAIR1_uc002qfo.2_Missense_Mutation_p.V73A	NM_002287	NP_002278	Q6GTX8	LAIR1_HUMAN	leukocyte-associated immunoglobulin-like	91	Extracellular (Potential).|Ig-like C2-type.					integral to membrane|plasma membrane	protein binding|receptor activity			ovary(4)	4	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0573)		TCCTTCACTTACTGAGTCAAT	0.498		NaN											0	0	0	0.008291	0	9	276									
EPS8L1	54869	broad.mit.edu	37	19	55594761	55594761	+	Silent	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:55594761G>A	uc002qis.3	+	13	1334	c.1230G>A	c.(1228-1230)CCG>CCA	p.P410P	EPS8L1_uc010ess.1_Silent_p.P392P|EPS8L1_uc010est.1_Silent_p.P410P|EPS8L1_uc010yfr.1_Silent_p.P346P|EPS8L1_uc010esu.1_RNA|EPS8L1_uc002qiu.2_Silent_p.P283P|EPS8L1_uc002qiv.2_Silent_p.P56P|EPS8L1_uc002qiw.2_Silent_p.P157P	NM_133180	NP_573441	Q8TE68	ES8L1_HUMAN	epidermal growth factor receptor pathway	410						cytoplasm					0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		AGCTGTCCCCGGAGGAGGGAC	0.627		NaN											0	0	0	0.00623	0	35	32									
TMEM150B	284417	broad.mit.edu	37	19	55824272	55824272	+	Silent	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:55824272G>A	uc010esw.1	-	8	830	c.657C>T	c.(655-657)CTC>CTT	p.L219L	TMEM150B_uc010yfu.1_Silent_p.L219L|TMEM150B_uc010yfv.1_RNA|TMEM150B_uc010yfw.1_RNA	NM_001085488	NP_001078957	A6NC51	T150B_HUMAN	transmembrane protein 150B precursor	219	Cytoplasmic (Potential).					integral to membrane					0						GCGGGGGGCTGAGGCTGGGCC	0.672		NaN											0	0	0	0.004482	0	7	13									
ZNF784	147808	broad.mit.edu	37	19	56133794	56133794	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:56133794C>G	uc002qll.1	-	2	309	c.295G>C	c.(295-297)GAC>CAC	p.D99H	ZNF784_uc010etb.1_RNA	NM_203374	NP_976308	Q8NCA9	ZN784_HUMAN	zinc finger protein 784	99					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)		CGGCTCGGGTCCCCACCCTGC	0.726		NaN											0	0	0	0.009096	0	4	19									
ZNF548	147694	broad.mit.edu	37	19	57908503	57908503	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:57908503G>A	uc002qom.2	+	2	353	c.103G>A	c.(103-105)GAT>AAT	p.D35N	ZNF547_uc002qpm.3_Intron|ZNF548_uc002qon.2_Missense_Mutation_p.D38N	NM_152909	NP_690873	Q8NEK5	ZN548_HUMAN	zinc finger protein 548	35	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GCTGTACCGTGATGTGATGCT	0.532		NaN											0	0	0	0.01441	0	169	425									
TPO	7173	broad.mit.edu	37	2	1459852	1459852	+	Missense_Mutation	SNP	G	G	T	rs144088710		TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr2:1459852G>T	uc002qww.2	+	7	708	c.617G>T	c.(616-618)CGG>CTG	p.R206L	TPO_uc010ewj.2_Intron|TPO_uc002qwu.2_Missense_Mutation_p.R206L|TPO_uc002qwr.2_Missense_Mutation_p.R206L|TPO_uc002qwx.2_Missense_Mutation_p.R206L|TPO_uc010yio.1_Missense_Mutation_p.R206L|TPO_uc010yip.1_Missense_Mutation_p.R206L	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	206	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	ACCCAGGTCCGGGAGGTGACA	0.502		NaN											1	0	0.000602214	0.000602	0.000627841	4	19									
BIRC6	57448	broad.mit.edu	37	2	32626615	32626615	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr2:32626615G>A	uc010ezu.2	+	8	1476	c.1342G>A	c.(1342-1344)GAT>AAT	p.D448N		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	448					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					CTCAGGAGTTGATTCAAGGAG	0.398		NaN											0	0	0	0.00623	0	42	51									
CYP1B1	1545	broad.mit.edu	37	2	38301609	38301609	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr2:38301609G>A	uc002rqo.2	-	3	1326	c.923C>T	c.(922-924)TCG>TTG	p.S308L		NM_000104	NP_000095	Q16678	CP1B1_HUMAN	cytochrome P450, family 1, subfamily B,	308					visual perception|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			ovary(1)|central_nervous_system(1)	2		all_hematologic(82;0.21)			Estrone(DB00655)	ACCACCGTGCGAGTCCCCGGC	0.542		NaN											0	0	0	0.010504	0	20	27									
STON1-GTF2A1L	286749	broad.mit.edu	37	2	48906488	48906488	+	Silent	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr2:48906488G>A	uc010yol.1	+	8	3362	c.3315G>A	c.(3313-3315)AAG>AAA	p.K1105K	STON1-GTF2A1L_uc002rwp.1_Silent_p.K1152K|GTF2A1L_uc002rws.1_Silent_p.K448K|GTF2A1L_uc010yom.1_Silent_p.K414K|GTF2A1L_uc002rwt.2_Intron	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	1105					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			ATCGAAGCAAGAACAAATGGA	0.353		NaN											0	0	0	0.005443	0	29	35									
NRXN1	9378	broad.mit.edu	37	2	50318575	50318575	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr2:50318575C>G	uc010fbp.2	-	3	1306	c.499G>C	c.(499-501)GAA>CAA	p.E167Q	NRXN1_uc002rxb.3_Missense_Mutation_p.E874Q|NRXN1_uc010fbq.2_Missense_Mutation_p.E1242Q|NRXN1_uc002rxe.3_Missense_Mutation_p.E1202Q	NM_138735	NP_620072	P58400	NRX1B_HUMAN	neurexin 1 isoform beta precursor	167	Extracellular (Potential).|Laminin G-like.				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GCATTGGATTCTTCAATGGCG	0.438		NaN											0	0	0	0.004656	0	27	126									
MTIF2	4528	broad.mit.edu	37	2	55464514	55464514	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr2:55464514C>A	uc002ryn.2	-	16	2658	c.1921G>T	c.(1921-1923)GTT>TTT	p.V641F	MTIF2_uc010yox.1_Missense_Mutation_p.V310F|MTIF2_uc002ryo.2_Missense_Mutation_p.V641F	NM_001005369	NP_001005369	P46199	IF2M_HUMAN	mitochondrial translational initiation factor 2	641					regulation of translational initiation	mitochondrion	GTP binding|GTPase activity|ribosomal small subunit binding|translation initiation factor activity			ovary(1)	1						GCCACAGGAACTTTTTTCTTC	0.373		NaN											1	0	1.08611e-07	0.010729	1.13838e-07	11	49									
IMMT	10989	broad.mit.edu	37	2	86389141	86389141	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr2:86389141C>T	uc002sqz.3	-	8	1242	c.854G>A	c.(853-855)AGA>AAA	p.R285K	IMMT_uc002sqy.3_Missense_Mutation_p.R26K|IMMT_uc002srb.3_Missense_Mutation_p.R274K|IMMT_uc002sra.3_Missense_Mutation_p.R284K|IMMT_uc010ytd.1_Missense_Mutation_p.R273K|IMMT_uc010yte.1_Missense_Mutation_p.R238K|IMMT_uc002src.1_Missense_Mutation_p.R26K|IMMT_uc002srd.2_Missense_Mutation_p.R285K|IMMT_uc002sre.3_Missense_Mutation_p.R273K|IMMT_uc010ytf.1_Missense_Mutation_p.R207K|IMMT_uc010fgs.1_Missense_Mutation_p.R282K	NM_006839	NP_006830	Q16891	IMMT_HUMAN	inner membrane protein, mitochondrial isoform 1	285	Mitochondrial intermembrane (Potential).					integral to mitochondrial inner membrane	protein binding			skin(1)	1						TACTGCCTTTCTGCGTTCCTT	0.428		NaN											0	0	0	0.003163	0	12	9									
GCC2	9648	broad.mit.edu	37	2	109086467	109086467	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr2:109086467C>T	uc002tec.2	+	6	836	c.682C>T	c.(682-684)CAG>TAG	p.Q228*	GCC2_uc002ted.2_Nonsense_Mutation_p.Q127*	NM_181453	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain-containing 2	228	Potential.				Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			ovary(1)	1						GGCTAATTCTCAGCATTACCA	0.358		NaN											0	0	0	0.011902	0	48	62									
POLR1B	84172	broad.mit.edu	37	2	113315529	113315529	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr2:113315529G>C	uc002thw.2	+	8	1781	c.1201G>C	c.(1201-1203)GAT>CAT	p.D401H	POLR1B_uc010fkn.2_Missense_Mutation_p.D345H|POLR1B_uc002thx.2_Missense_Mutation_p.D262H|POLR1B_uc010fko.2_Intron|POLR1B_uc010fkp.2_Intron|POLR1B_uc010yxn.1_Missense_Mutation_p.D439H|POLR1B_uc002thy.2_Missense_Mutation_p.D262H|POLR1B_uc010yxo.1_Missense_Mutation_p.D178H	NM_019014	NP_061887	Q9H9Y6	RPA2_HUMAN	RNA polymerase I polypeptide B isoform 1	401					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			ovary(1)	1						AATAGCTTTTGATAAGAAGGC	0.284		NaN											0	0	0	0.000602	0	5	12									
LRP1B	53353	broad.mit.edu	37	2	140995786	140995786	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr2:140995786C>T	uc002tvj.1	-	89	14467	c.13495G>A	c.(13495-13497)GAG>AAG	p.E4499K		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4499	Cytoplasmic (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TGATCTACCTCATACATGTTA	0.338		NaN								TSP Lung(27;0.18)			0	0	0	0.008291	0	11	54									
OLA1	29789	broad.mit.edu	37	2	175006600	175006600	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr2:175006600C>G	uc002uih.2	-	5	688	c.502G>C	c.(502-504)GAA>CAA	p.E168Q	OLA1_uc002uii.2_Missense_Mutation_p.E10Q|OLA1_uc010fqq.2_Missense_Mutation_p.E168Q|OLA1_uc002uij.2_Missense_Mutation_p.E10Q|OLA1_uc002uik.2_Missense_Mutation_p.E138Q|OLA1_uc010fqr.2_Missense_Mutation_p.E168Q	NM_013341	NP_037473	Q9NTK5	OLA1_HUMAN	Obg-like ATPase 1 isoform 1	168			E -> Q (in a breast cancer sample; somatic mutation).		ATP catabolic process	cytoplasm	ATP binding|GTP binding|hydrolase activity|protein binding	p.E168Q(1)		ovary(1)|breast(1)	2						GCCACCTTTTCTAGTTTATCT	0.328		NaN											0	0	0	0.010504	0	18	48									
CIR1	9541	broad.mit.edu	37	2	175213677	175213677	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr2:175213677C>T	uc002uim.2	-	10	994	c.901G>A	c.(901-903)GGG>AGG	p.G301R	CIR1_uc002uin.2_Missense_Mutation_p.G175R|CIR1_uc002uio.2_Missense_Mutation_p.G128R|CIR1_uc002uip.2_Missense_Mutation_p.G190R	NM_004882	NP_004873	Q86X95	CIR1_HUMAN	CBF1 interacting corepressor	301	Lys/Ser-rich.				mRNA processing|negative regulation of transcription, DNA-dependent|RNA splicing	nuclear speck	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			large_intestine(1)	1						TTGTTATGCCCTGAACACttg	0.313		NaN											0	0	0	0.010818	0	33	66									
TTN	7273	broad.mit.edu	37	2	179424596	179424596	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr2:179424596C>T	uc010zfg.1	-	275	78783	c.78559G>A	c.(78559-78561)GAT>AAT	p.D26187N	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D19882N|TTN_uc010zfi.1_Missense_Mutation_p.D19815N|TTN_uc010zfj.1_Missense_Mutation_p.D19690N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	27114							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGTCAATATCAAATAAAGGT	0.433		NaN											0	0	0	0.012213	0	32	63									
CERKL	375298	broad.mit.edu	37	2	182438553	182438553	+	Missense_Mutation	SNP	T	T	A	rs149505471		TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr2:182438553T>A	uc002unx.2	-	3	641	c.540A>T	c.(538-540)AAA>AAT	p.K180N	CERKL_uc002uny.2_Missense_Mutation_p.K180N|CERKL_uc010zfm.1_Intron|CERKL_uc002unz.2_Translation_Start_Site|CERKL_uc002uoa.2_Missense_Mutation_p.K180N|CERKL_uc002uob.2_Intron|CERKL_uc002uoc.2_Intron|CERKL_uc010frk.2_Intron|CERKL_uc002uod.1_Translation_Start_Site|CERKL_uc002uoe.2_Missense_Mutation_p.K180N	NM_001030311	NP_001025482	Q49MI3	CERKL_HUMAN	ceramide kinase-like isoform b	180	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis	endoplasmic reticulum|endoplasmic reticulum|Golgi apparatus|Golgi apparatus|nucleolus|nucleolus	diacylglycerol kinase activity			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.088)			GGGTAGCTTCTTTTTTGTGAC	0.333		NaN											0	0	0	0.012319	0	19	34									
STAT4	6775	broad.mit.edu	37	2	191897696	191897696	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr2:191897696G>C	uc002usm.1	-	21	2286	c.2032C>G	c.(2032-2034)CAG>GAG	p.Q678E	STAT4_uc002usn.1_Missense_Mutation_p.Q678E|STAT4_uc010zgk.1_Missense_Mutation_p.Q523E|STAT4_uc002uso.2_Missense_Mutation_p.Q678E	NM_003151	NP_003142	Q14765	STAT4_HUMAN	signal transducer and activator of transcription	678					JAK-STAT cascade	cytoplasm|nucleus	calcium ion binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(3)|skin(2)|lung(1)|ovary(1)|prostate(1)|pancreas(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.0864)|all cancers(119;0.204)			TCGCAAGGCTGAGAGCTGTAG	0.368		NaN											0	0	0	0.010729	0	11	37									
FZD7	8324	broad.mit.edu	37	2	202900750	202900750	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr2:202900750G>C	uc002uyw.1	+	1	1441	c.1380G>C	c.(1378-1380)AAG>AAC	p.K460N		NM_003507	NP_003498	O75084	FZD7_HUMAN	frizzled 7 precursor	460	Cytoplasmic (Potential).				axonogenesis|brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|mesenchymal to epithelial transition|negative regulation of cell-substrate adhesion|negative regulation of ectodermal cell fate specification|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of phosphorylation|positive regulation of transcription, DNA-dependent|regulation of catenin import into nucleus|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			skin(2)|ovary(1)|breast(1)	4						ACGGCACCAAGACCGAGAAGC	0.592		NaN									OREG0015146	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008871	0	16	35									
SPHKAP	80309	broad.mit.edu	37	2	228882308	228882308	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr2:228882308C>G	uc002vpq.2	-	7	3309	c.3262G>C	c.(3262-3264)GAG>CAG	p.E1088Q	SPHKAP_uc002vpp.2_Missense_Mutation_p.E1088Q|SPHKAP_uc010zlx.1_Missense_Mutation_p.E1088Q	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1088						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GAGTCTTCCTCAGGAATGCTT	0.632		NaN											0	0	0	0.013537	0	10	34									
FAM110A	83541	broad.mit.edu	37	20	825768	825768	+	Silent	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr20:825768C>T	uc002wef.1	+	2	657	c.321C>T	c.(319-321)CTC>CTT	p.L107L	FAM110A_uc002weg.1_Silent_p.L107L|FAM110A_uc002weh.1_Silent_p.L107L|FAM110A_uc010fzz.2_RNA	NM_001042353	NP_001035812	Q9BQ89	F110A_HUMAN	hypothetical protein LOC83541	107						microtubule organizing center|spindle pole	protein binding				0						TGGACATCCTCAGCAGCCTCA	0.721		NaN											0	0	0	0.010729	0	9	9									
SIRPB2	284759	broad.mit.edu	37	20	1456880	1456880	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr20:1456880C>T	uc002wfg.2	-	5	1189	c.961G>A	c.(961-963)GAA>AAA	p.E321K	SIRPB2_uc002wfh.3_Missense_Mutation_p.E223K	NM_001122962	NP_001116434	Q5JXA9	SIRB2_HUMAN	signal-regulatory protein beta 2 isoform 1	321	Cytoplasmic (Potential).					integral to membrane					0						TTGACATCTTCTTGCCCAGGG	0.597		NaN											0	0	0	0.01441	0	65	139									
NOP56	10528	broad.mit.edu	37	20	2635071	2635071	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr20:2635071G>C	uc002wgh.2	+	4	273	c.220G>C	c.(220-222)GAG>CAG	p.E74Q	NOP56_uc010zpy.1_RNA|NOP56_uc002wgi.2_5'UTR|SNORA51_uc002wgk.1_5'Flank|NOP56_uc002wgm.1_5'Flank|SNORD86_uc010gaq.1_5'Flank|SNORD56_uc010gar.2_5'Flank|SNORD57_uc002wgo.1_5'Flank	NM_006392	NP_006383	O00567	NOP56_HUMAN	nucleolar protein 5A	74					rRNA processing	box C/D snoRNP complex|pre-snoRNP complex	protein binding|snoRNA binding			ovary(1)|pancreas(1)	2						GGTTGTTCATGAGGACCTCCG	0.542		NaN											0	0	0	0.010818	0	31	53									
NOP56	10528	broad.mit.edu	37	20	2635517	2635517	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr20:2635517G>C	uc002wgh.2	+	5	546	c.493G>C	c.(493-495)GAC>CAC	p.D165H	NOP56_uc010zpy.1_RNA|NOP56_uc002wgi.2_5'UTR|SNORA51_uc002wgk.1_5'Flank|NOP56_uc002wgm.1_5'Flank|SNORD86_uc010gaq.1_5'Flank|SNORD56_uc010gar.2_5'Flank|SNORD57_uc002wgo.1_5'Flank	NM_006392	NP_006383	O00567	NOP56_HUMAN	nucleolar protein 5A	165					rRNA processing	box C/D snoRNP complex|pre-snoRNP complex	protein binding|snoRNA binding			ovary(1)|pancreas(1)	2						GAACCGGGTGGACAATATGAT	0.502		NaN											0	0	0	0.01441	0	132	120									
TMX4	56255	broad.mit.edu	37	20	7963265	7963265	+	Missense_Mutation	SNP	T	T	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr20:7963265T>A	uc002wmx.1	-	8	816	c.683A>T	c.(682-684)CAG>CTG	p.Q228L		NM_021156	NP_066979	Q9H1E5	TMX4_HUMAN	thioredoxin-related transmembrane protein 4	228	Glu-rich.				cell redox homeostasis|electron transport chain|transport	integral to membrane					0						TCTCCGATTCTGCTCTATGGA	0.308		NaN											0	0	0	0.00632	0	27	57									
FLRT3	23767	broad.mit.edu	37	20	14307164	14307164	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr20:14307164C>T	uc002wov.1	-	3	1456	c.989G>A	c.(988-990)CGT>CAT	p.R330H	MACROD2_uc002wot.2_Intron|MACROD2_uc002wou.2_Intron|FLRT3_uc002wow.1_Missense_Mutation_p.R330H	NM_198391	NP_938205	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	330	Extracellular (Potential).|LRRCT.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			kidney(1)	1		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		CATGAGCCCACGCACGTTGAC	0.473		NaN											0	0	0	0.007835	0	40	124									
CST9L	128821	broad.mit.edu	37	20	23549013	23549013	+	Silent	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr20:23549013C>T	uc002wtk.3	-	1	374	c.75G>A	c.(73-75)CTG>CTA	p.L25L		NM_080610	NP_542177	Q9H4G1	CST9L_HUMAN	cystatin 9-like precursor	25						extracellular region	cysteine-type endopeptidase inhibitor activity				0	Colorectal(13;0.0431)|Lung NSC(19;0.235)					AGGCATAGATCAGCAGGATCT	0.567		NaN											0	0	0	0.012213	0	33	21									
SNTA1	6640	broad.mit.edu	37	20	32000163	32000163	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr20:32000163G>C	uc002wzd.1	-	5	1251	c.979C>G	c.(979-981)CTC>GTC	p.L327V	SNTA1_uc010zuf.1_Intron	NM_003098	NP_003089	Q13424	SNTA1_HUMAN	acidic alpha 1 syntrophin	327	PH 2.				muscle contraction	cell junction|cytoplasm|cytoskeleton|sarcolemma	actin binding|calmodulin binding			skin(1)	1						GTCTCGGGGAGAGACAAGTAG	0.632		NaN											0	0	0	0.004007	0	13	35									
ITCH	83737	broad.mit.edu	37	20	33026353	33026353	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr20:33026353C>G	uc010geu.1	+	9	911	c.719C>G	c.(718-720)TCT>TGT	p.S240C	ITCH_uc002xak.2_Missense_Mutation_p.S199C|ITCH_uc010zuj.1_Missense_Mutation_p.S89C	NM_031483	NP_113671	Q96J02	ITCH_HUMAN	itchy homolog E3 ubiquitin protein ligase	240					apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity			breast(4)|lung(1)|central_nervous_system(1)	6						GGGAATAATTCTCCATCACTC	0.483		NaN											0	0	0	0.01441	0	72	56									
RPRD1B	58490	broad.mit.edu	37	20	36662412	36662412	+	Silent	SNP	G	G	A	rs17853182		TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr20:36662412G>A	uc002xho.3	+	1	465	c.63G>A	c.(61-63)CAG>CAA	p.Q21Q	KIAA0406_uc002xhl.2_5'Flank|KIAA0406_uc002xhm.2_5'Flank	NM_021215	NP_067038	Q9NQG5	RPR1B_HUMAN	Regulation of nuclear pre-mRNA domain containing	21	CID.			Q -> H (in Ref. 5; AAH33629).						pancreas(1)	1						ACTCTCAGCAGAGCGTGCAGA	0.642		NaN											0	0	0	0.01441	0	58	91									
ELMO2	63916	broad.mit.edu	37	20	45002118	45002118	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr20:45002118C>G	uc002xrt.1	-	16	1546	c.1336G>C	c.(1336-1338)GAA>CAA	p.E446Q	ELMO2_uc010zxq.1_Missense_Mutation_p.E178Q|ELMO2_uc002xrs.1_Missense_Mutation_p.E193Q|ELMO2_uc002xru.1_Missense_Mutation_p.E446Q|ELMO2_uc010zxr.1_Missense_Mutation_p.E458Q|ELMO2_uc010zxs.1_Missense_Mutation_p.E263Q|ELMO2_uc002xrv.1_Missense_Mutation_p.E165Q|ELMO2_uc002xrw.2_Missense_Mutation_p.E263Q	NM_133171	NP_573403	Q96JJ3	ELMO2_HUMAN	engulfment and cell motility 2	446	ELMO.				apoptosis|cell chemotaxis|phagocytosis	cytoskeleton|cytosol|membrane	lyase activity|receptor tyrosine kinase binding|SH3 domain binding			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				AAGAGCTCTTCAAAGGCTCGG	0.502		NaN											0	0	0	0.004289	0	39	51									
SULF2	55959	broad.mit.edu	37	20	46313304	46313304	+	Silent	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr20:46313304C>T	uc002xto.2	-	6	1089	c.759G>A	c.(757-759)GCG>GCA	p.A253A	SULF2_uc002xtr.2_Silent_p.A253A|SULF2_uc002xtq.2_Silent_p.A253A	NM_018837	NP_061325	Q8IWU5	SULF2_HUMAN	sulfatase 2 isoform a precursor	253					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						CCGGGTTGGGCGCGTAGTTGT	0.632		NaN											0	0	0	0.00308	0	8	46									
SNAI1	6615	broad.mit.edu	37	20	48604577	48604577	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr20:48604577C>T	uc002xuz.2	+	3	849	c.779C>T	c.(778-780)TCA>TTA	p.S260L		NM_005985	NP_005976	O95863	SNAI1_HUMAN	snail 1 homolog	260					epithelial to mesenchymal transition|mesoderm formation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	kinase binding|zinc ion binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(9;4.03e-06)			TCCGGCTGCTCAGGATGTCCC	0.617		NaN											0	0	0	0.005524	0	37	33									
ADAMTS5	11096	broad.mit.edu	37	21	28296403	28296403	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr21:28296403G>C	uc002ymg.2	-	8	3491	c.2762C>G	c.(2761-2763)GCG>GGG	p.A921G		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	921	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						TTGCTTAAACGCAGAAGGCCT	0.483		NaN											0	0	0	0.004007	0	15	51									
GNB1L	54584	broad.mit.edu	37	22	19794230	19794230	+	Silent	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr22:19794230C>T	uc002zqe.1	-	5	862	c.468G>A	c.(466-468)CCG>CCA	p.P156P	GNB1L_uc002zqd.1_Silent_p.P12P|GNB1L_uc002zqf.1_Silent_p.P156P	NM_053004	NP_443730	Q9BYB4	GNB1L_HUMAN	guanine nucleotide binding protein	156					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	internal side of plasma membrane|intracellular				breast(1)	1	Colorectal(54;0.0993)					CATCTGCCTTCGGCTTCAGGG	0.622		NaN											0	0	0	0.003755	0	29	35									
RTDR1	27156	broad.mit.edu	37	22	23404081	23404081	+	Silent	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr22:23404081G>A	uc002zwt.2	-	6	854	c.696C>T	c.(694-696)GTC>GTT	p.V232V		NM_014433	NP_055248	Q9UHP6	RTDR1_HUMAN	rhabdoid tumor deletion region protein 1	232							binding			ovary(1)	1	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.175)		GGATGGGGATGACGTCAAAAT	0.562		NaN											0	0	0	0.007835	0	40	29									
CABIN1	23523	broad.mit.edu	37	22	24472152	24472152	+	Silent	SNP	C	C	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr22:24472152C>A	uc002zzi.1	+	19	2794	c.2667C>A	c.(2665-2667)CTC>CTA	p.L889L	CABIN1_uc002zzj.1_Silent_p.L839L|CABIN1_uc002zzl.1_Silent_p.L889L	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	889					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						CATCCTCCCTCATGCTGCTGA	0.587		NaN											1	0	6.38683e-12	0.008361	6.80336e-12	26	96									
HSCB	150274	broad.mit.edu	37	22	29153094	29153094	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr22:29153094G>C	uc003aea.2	+	6	686	c.645G>C	c.(643-645)TTG>TTC	p.L215F		NM_172002	NP_741999	Q8IWL3	HSC20_HUMAN	J-type co-chaperone HSC20 precursor	215					iron-sulfur cluster assembly|protein folding	mitochondrion	chaperone binding|heat shock protein binding|metal ion binding			kidney(1)	1						AGGAAATTTTGACAAAGATGA	0.318		NaN											0	0	0	0.01441	0	44	98									
APOL5	80831	broad.mit.edu	37	22	36122831	36122831	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr22:36122831G>A	uc003aof.2	+	3	716	c.716G>A	c.(715-717)GGC>GAC	p.G239D		NM_030642	NP_085145	Q9BWW9	APOL5_HUMAN	apolipoprotein L5	239					lipid metabolic process|lipid transport|lipoprotein metabolic process	cytoplasm|extracellular region	high-density lipoprotein particle binding|lipid binding|protein binding				0						GCTATCCAGGGCATCAAGGAT	0.468		NaN											0	0	0	0.009096	0	4	178									
TTLL8	164714	broad.mit.edu	37	22	50471761	50471761	+	Missense_Mutation	SNP	T	T	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr22:50471761T>G	uc011ark.1	-	10	1153	c.1153A>C	c.(1153-1155)ATC>CTC	p.I385L		NM_001080447	NP_001073916			tubulin tyrosine ligase-like family, member 8											ovary(2)	2		all_cancers(38;3.44e-07)|all_epithelial(38;2.44e-06)|all_lung(38;0.00141)|Breast(42;0.00519)|Lung NSC(38;0.0199)|Ovarian(80;0.142)|Lung SC(80;0.162)		READ - Rectum adenocarcinoma(2;0.000882)|Colorectal(2;0.00311)|BRCA - Breast invasive adenocarcinoma(115;0.226)		GTGTCACAGATGAGCAGCGGC	0.562		NaN											0	0	0	0.004482	0	9	5									
HRH1	3269	broad.mit.edu	37	3	11301783	11301783	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr3:11301783G>A	uc010hdr.2	+	2	1402	c.1060G>A	c.(1060-1062)GAT>AAT	p.D354N	HRH1_uc010hds.2_Missense_Mutation_p.D354N|HRH1_uc010hdt.2_Missense_Mutation_p.D354N|HRH1_uc003bwb.3_Missense_Mutation_p.D354N	NM_001098213	NP_001091683	P35367	HRH1_HUMAN	histamine receptor H1	354	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|inflammatory response	cytoplasm|integral to plasma membrane|nucleus	histamine receptor activity			large_intestine(1)|ovary(1)	2					Aceprometazine(DB01615)|Astemizole(DB00637)|Azatadine(DB00719)|Azelastine(DB00972)|Benzquinamide(DB00767)|Bepotastine(DB04890)|Bromodiphenhydramine(DB01237)|Brompheniramine(DB00835)|Buclizine(DB00354)|Carbinoxamine(DB00748)|Cetirizine(DB00341)|Chlophedianol(DB04837)|Chlorpheniramine(DB01114)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clemastine(DB00283)|Clozapine(DB00363)|Cyclizine(DB01176)|Cyproheptadine(DB00434)|Desipramine(DB01151)|Desloratadine(DB00967)|Dexbrompheniramine(DB00405)|Dimenhydrinate(DB00985)|Diphenhydramine(DB01075)|Diphenylpyraline(DB01146)|Doxepin(DB01142)|Doxylamine(DB00366)|Emedastine(DB01084)|Epinastine(DB00751)|Fexofenadine(DB00950)|Flunarizine(DB04841)|Histamine Phosphate(DB00667)|Hydroxyzine(DB00557)|Ketotifen(DB00920)|Levocabastine(DB01106)|Loratadine(DB00455)|Maprotiline(DB00934)|Meclizine(DB00737)|Mequitazine(DB01071)|Methdilazine(DB00902)|Methotrimeprazine(DB01403)|Mianserin(DB06148)|Mirtazapine(DB00370)|Nedocromil(DB00716)|Olanzapine(DB00334)|Olopatadine(DB00768)|Orphenadrine(DB01173)|Pemirolast(DB00885)|Phenindamine(DB01619)|Pheniramine(DB01620)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Terfenadine(DB00342)|Thiethylperazine(DB00372)|Trazodone(DB00656)|Trimeprazine(DB01246)|Tripelennamine(DB00792)|Triprolidine(DB00427)|Ziprasidone(DB00246)	GATGTTAGGTGATAGCCAATC	0.527		NaN											0	0	0	0.013726	0	35	49									
FGD5	152273	broad.mit.edu	37	3	14922086	14922086	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr3:14922086G>A	uc003bzc.2	+	3	2776	c.2666G>A	c.(2665-2667)GGA>GAA	p.G889E	FGD5_uc011avk.1_Missense_Mutation_p.G889E|FGD5_uc003bzd.2_5'Flank	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	889					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						CAGGTGGAAGGACAGTCCAGA	0.527		NaN											0	0	0	0.003163	0	16	22									
FGD5	152273	broad.mit.edu	37	3	14964612	14964612	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr3:14964612G>A	uc003bzc.2	+	16	3977	c.3867G>A	c.(3865-3867)ATG>ATA	p.M1289I	FGD5_uc011avk.1_Missense_Mutation_p.M1289I|FGD5_uc003bzd.2_Missense_Mutation_p.M367I	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	1289	FYVE-type.			M -> T (in Ref. 5; CAE45896).	actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						AGGACAGGATGGCCAAGGTCT	0.607		NaN											0	0	0	0.009535	0	31	50									
SACM1L	22908	broad.mit.edu	37	3	45773624	45773624	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr3:45773624G>C	uc003cos.2	+	13	1285	c.1081G>C	c.(1081-1083)GAA>CAA	p.E361Q	SACM1L_uc011bag.1_Missense_Mutation_p.E258Q|SACM1L_uc011bah.1_Missense_Mutation_p.E295Q|SACM1L_uc003cot.2_5'Flank	NM_014016	NP_054735	Q9NTJ5	SAC1_HUMAN	suppressor of actin 1	361	SAC.					Golgi apparatus				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0102)|KIRC - Kidney renal clear cell carcinoma(197;0.0234)|Kidney(197;0.0277)		TCAGGTAGCAGAAATGCAAGA	0.333		NaN											0	0	0	0.00632	0	29	63									
TCTA	6988	broad.mit.edu	37	3	49452277	49452277	+	Silent	SNP	C	C	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr3:49452277C>G	uc003cwv.3	+	3	515	c.294C>G	c.(292-294)CTC>CTG	p.L98L	RHOA_uc010hku.2_5'Flank|RHOA_uc003cwu.2_5'Flank	NM_022171	NP_071503	P57738	TCTA_HUMAN	T-cell leukemia translocation altered	98	Extracellular (Potential).					integral to membrane					0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		ACGAACCTCTCAAAACCCACA	0.522		NaN											0	0	0	0.001984	0	5	23									
MST1	4485	broad.mit.edu	37	3	49722087	49722087	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr3:49722087G>T	uc003cxg.2	-	16	1844	c.1772C>A	c.(1771-1773)TCT>TAT	p.S591Y		NM_020998	NP_066278	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth	577	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CAGGGTCACAGATCTTTAGCA	0.602		NaN											1	0	2.32078e-09	0.003163	2.44556e-09	15	53									
CACNA2D2	9254	broad.mit.edu	37	3	50403560	50403560	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr3:50403560A>G	uc003daq.2	-	33	2803	c.2765T>C	c.(2764-2766)CTG>CCG	p.L922P	CACNA2D2_uc003dap.2_Missense_Mutation_p.L915P|CACNA2D2_uc003dao.2_5'Flank	NM_006030	NP_006021	Q9NY47	CA2D2_HUMAN	calcium channel, voltage-dependent, alpha	922	Extracellular (Potential).				energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000365)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)	Gabapentin(DB00996)	TGCCAGCATCAGGTTGGCATC	0.567		NaN											0	0	0	0.004672	0	3	92									
STAB1	23166	broad.mit.edu	37	3	52547747	52547747	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr3:52547747G>C	uc003dej.2	+	31	3359	c.3285G>C	c.(3283-3285)CAG>CAC	p.Q1095H		NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	1095	FAS1 3.|Extracellular (Potential).				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		TCTGGGTGCAGAATGCCAGCG	0.597		NaN											0	0	0	0.001168	0	6	17									
NT5DC2	64943	broad.mit.edu	37	3	52558714	52558714	+	Silent	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr3:52558714G>A	uc003deo.2	-	14	1759	c.1335C>T	c.(1333-1335)TTC>TTT	p.F445F	NT5DC2_uc003dem.2_Silent_p.F315F|NT5DC2_uc003den.2_Silent_p.F482F|NT5DC2_uc010hmi.2_Silent_p.F457F|NT5DC2_uc010hmj.2_Silent_p.F261F	NM_022908	NP_075059	Q9H857	NT5D2_HUMAN	5'-nucleotidase domain containing 2 isoform 2	445							hydrolase activity|metal ion binding				0				BRCA - Breast invasive adenocarcinoma(193;1.7e-05)|Kidney(197;0.00177)|KIRC - Kidney renal clear cell carcinoma(197;0.002)|OV - Ovarian serous cystadenocarcinoma(275;0.0476)		AGATGCTGCCGAACTGCGCAT	0.627		NaN											0	0	0	0.003163	0	15	38									
CGGBP1	8545	broad.mit.edu	37	3	88104763	88104763	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr3:88104763C>T	uc003dqs.2	-	4	876	c.364G>A	c.(364-366)GAT>AAT	p.D122N	CGGBP1_uc003dqt.2_Missense_Mutation_p.D122N|CGGBP1_uc003dqu.2_Missense_Mutation_p.D122N	NM_001008390	NP_001008391	Q9UFW8	CGBP1_HUMAN	CGG triplet repeat binding protein 1	122					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	double-stranded DNA binding				0		Lung NSC(201;0.0283)		LUSC - Lung squamous cell carcinoma(29;0.00359)|Lung(72;0.00677)		GCTGGGTGATCAGCCTTCTCA	0.488		NaN											0	0	0	0.010504	0	22	54									
KIAA1524	57650	broad.mit.edu	37	3	108271090	108271090	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr3:108271090C>G	uc003dxb.3	-	20	2807	c.2538G>C	c.(2536-2538)TTG>TTC	p.L846F		NM_020890	NP_065941	Q8TCG1	CIP2A_HUMAN	p90 autoantigen	846	Potential.					cytoplasm|integral to membrane	protein binding			ovary(2)|central_nervous_system(1)	3						CCTTAATGCTCAACTCTTTTC	0.313		NaN											0	0	0	0.013537	0	12	26									
BOC	91653	broad.mit.edu	37	3	112998700	112998700	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr3:112998700C>G	uc003dzx.2	+	13	2671	c.2050C>G	c.(2050-2052)CTG>GTG	p.L684V	BOC_uc003dzy.2_Missense_Mutation_p.L684V|BOC_uc003dzz.2_Missense_Mutation_p.L685V|BOC_uc003eab.2_Missense_Mutation_p.L385V|BOC_uc003eac.2_5'UTR	NM_033254	NP_150279	Q9BWV1	BOC_HUMAN	brother of CDO precursor	684	Fibronectin type-III 2.|Extracellular (Potential).				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|pancreas(1)	6			Epithelial(53;0.227)			AGTCCGGGCTCTGAACATGCT	0.612		NaN											0	0	0	0.01441	0	55	118									
PLXND1	23129	broad.mit.edu	37	3	129289674	129289674	+	Silent	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr3:129289674C>T	uc003emx.2	-	19	3805	c.3705G>A	c.(3703-3705)TCG>TCA	p.S1235S		NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	1235	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						ACTCGTTGACCGAGCAGTGGA	0.622		NaN											0	0	0	0.01441	0	115	159									
CEP70	80321	broad.mit.edu	37	3	138219388	138219388	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr3:138219388G>A	uc003esl.2	-	15	1588	c.1390C>T	c.(1390-1392)CAA>TAA	p.Q464*	CEP70_uc011bmk.1_Nonsense_Mutation_p.Q444*|CEP70_uc011bml.1_Nonsense_Mutation_p.Q446*|CEP70_uc011bmm.1_Nonsense_Mutation_p.Q312*|CEP70_uc003esm.2_Nonsense_Mutation_p.Q464*	NM_024491	NP_077817	Q8NHQ1	CEP70_HUMAN	centrosomal protein 70 kDa	464					G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			skin(1)	1						TGCAAAGTTTGAAAGTGTGGC	0.323		NaN											0	0	0	0.01441	0	116	255									
RBP1	5947	broad.mit.edu	37	3	139258320	139258320	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr3:139258320C>T	uc003eti.2	-	1	352	c.241G>A	c.(241-243)GAG>AAG	p.E81K	RBP1_uc011bmx.1_Missense_Mutation_p.E81K|RBP1_uc010huj.2_RNA|RBP1_uc011bmy.1_Missense_Mutation_p.E81K	NM_002899	NP_002890	P09455	RET1_HUMAN	retinol binding protein 1, cellular isoform a	19						cytoplasm	retinal binding|retinol binding|transporter activity				0					Vitamin A(DB00162)	CGCAGGTACTCCTCGAAATTC	0.677		NaN											0	0	0	0.013537	0	11	8									
TNIK	23043	broad.mit.edu	37	3	170945999	170945999	+	Silent	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr3:170945999G>C	uc003fhh.2	-	3	480	c.135C>G	c.(133-135)GTC>GTG	p.V45V	TNIK_uc003fhi.2_Silent_p.V45V|TNIK_uc003fhj.2_Silent_p.V45V|TNIK_uc003fhk.2_Silent_p.V45V|TNIK_uc003fhl.2_Silent_p.V45V|TNIK_uc003fhm.2_Silent_p.V45V|TNIK_uc003fhn.2_Silent_p.V45V|TNIK_uc003fho.2_Silent_p.V45V	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	45	Protein kinase.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			GGCCCGTTTTGACATGACGAC	0.338		NaN											0	0	0	0.01441	0	81	42									
MCF2L2	23101	broad.mit.edu	37	3	183014889	183014889	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr3:183014889G>C	uc003fli.1	-	12	1462	c.1372C>G	c.(1372-1374)CGA>GGA	p.R458G	MCF2L2_uc003flj.1_Missense_Mutation_p.R458G|MCF2L2_uc011bqr.1_Intron|uc003fln.1_RNA|uc003flo.2_5'Flank	NM_015078	NP_055893	Q86YR7	MF2L2_HUMAN	Rho family guanine-nucleotide exchange factor	458					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|large_intestine(2)|breast(1)	5	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			ACCCCTTCTCGAGACTGGCAC	0.517		NaN											0	0	0	0.006214	0	8	90									
EIF2B5	8893	broad.mit.edu	37	3	183858320	183858320	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr3:183858320C>T	uc003fmp.2	+	7	1322	c.958C>T	c.(958-960)CCT>TCT	p.P320S	EIF2B5_uc003fmq.2_Missense_Mutation_p.P41S|EIF2B5_uc003fmr.2_5'Flank	NM_003907	NP_003898	Q13144	EI2BE_HUMAN	eukaryotic translation initiation factor 2B,	320					astrocyte development|myelination|negative regulation of translational initiation in response to stress|oligodendrocyte development|ovarian follicle development|positive regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus|RNA metabolic process	cytosol|eukaryotic translation initiation factor 2B complex|nucleus	guanyl-nucleotide exchange factor activity|transferase activity|translation initiation factor activity|translation initiation factor binding			ovary(5)	5	all_cancers(143;7.59e-11)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			ATGGGTCTACCCTCTCACCCC	0.577		NaN											0	0	0	0.01441	0	93	129									
LSG1	55341	broad.mit.edu	37	3	194392818	194392818	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr3:194392818C>T	uc003fui.2	-	1	389	c.74G>A	c.(73-75)CGA>CAA	p.R25Q		NM_018385	NP_060855	Q9H089	LSG1_HUMAN	large subunit GTPase 1	25					nuclear export|protein transport	Cajal body|endoplasmic reticulum	GTP binding|hydrolase activity				0	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;7.55e-06)		ACGATGGCTTCGGCTCCGCTG	0.567		NaN											0	0	0	0.007291	0	27	47									
PACRGL	133015	broad.mit.edu	37	4	20715142	20715142	+	Silent	SNP	C	C	T	rs139070230	byFrequency	TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr4:20715142C>T	uc010iek.2	+	7	980	c.589C>T	c.(589-591)CTG>TTG	p.L197L	PACRGL_uc003gpu.2_RNA|PACRGL_uc010iei.1_Silent_p.L245L|PACRGL_uc003gpz.2_Silent_p.L197L|PACRGL_uc011bxm.1_Silent_p.L144L|PACRGL_uc003gqa.2_Silent_p.L99L|PACRGL_uc003gpx.3_RNA|PACRGL_uc003gpv.2_Silent_p.L197L|PACRGL_uc003gpw.2_RNA|PACRGL_uc010iej.1_RNA|PACRGL_uc011bxn.1_Silent_p.L99L|PACRGL_uc003gpy.2_Silent_p.L144L	NM_145048	NP_659485	Q8N7B6	PACRL_HUMAN	PARK2 co-regulated-like isoform 1	197							binding				0						AAACGACCATCTGAAGCATCT	0.388		NaN											0	0	0	0.008871	0	21	39									
SEPSECS	51091	broad.mit.edu	37	4	25160685	25160685	+	Silent	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr4:25160685G>C	uc003grg.2	-	2	372	c.159C>G	c.(157-159)CTC>CTG	p.L53L	uc003grj.2_5'Flank|PI4K2B_uc011bxs.1_5'Flank|SEPSECS_uc003gri.2_Silent_p.L52L|SEPSECS_uc003grh.2_Intron	NM_153825	NP_722547	Q9HD40	SPCS_HUMAN	Sep (O-phosphoserine) tRNA:Sec (selenocysteine)	53					selenocysteine incorporation	cytoplasm|nucleus	pyridoxal phosphate binding|transferase activity, transferring selenium-containing groups|tRNA binding				0		Breast(46;0.173)			Pyridoxal Phosphate(DB00114)	CATGTAAAAAGAGTTCAAGTG	0.383		NaN											0	0	0	0.007291	0	27	64									
FRAS1	80144	broad.mit.edu	37	4	79360104	79360104	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr4:79360104C>G	uc003hlb.2	+	40	5855	c.5415C>G	c.(5413-5415)TTC>TTG	p.F1805L	FRAS1_uc003hkw.2_Missense_Mutation_p.F1805L|FRAS1_uc010ijj.1_Missense_Mutation_p.F225L	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	1804	CSPG 6.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						CTGATAGCTTCTATTTCTCTG	0.388		NaN											0	0	0	0.00278	0	23	91									
PPP3CA	5530	broad.mit.edu	37	4	101984485	101984485	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr4:101984485T>C	uc011cen.1	-	9	1660	c.985A>G	c.(985-987)ATG>GTG	p.M329V	PPP3CA_uc003hvu.2_Missense_Mutation_p.M329V|PPP3CA_uc010ilj.2_Intron|PPP3CA_uc003hvt.2_Missense_Mutation_p.M316V|PPP3CA_uc003hvs.2_Missense_Mutation_p.M262V|PPP3CA_uc010ilk.2_Missense_Mutation_p.M97V	NM_000944	NP_000935	Q08209	PP2BA_HUMAN	protein phosphatase 3, catalytic subunit, alpha	329					protein dephosphorylation	calcineurin complex|cytosol|nucleus	calcium ion binding|calmodulin binding			ovary(1)|skin(1)	2				OV - Ovarian serous cystadenocarcinoma(123;6.79e-08)		CTGATATTCATAACATTGTTC	0.363		NaN											0	0	0	0.006214	0	10	10									
FAT4	79633	broad.mit.edu	37	4	126241535	126241535	+	Missense_Mutation	SNP	T	T	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr4:126241535T>A	uc003ifj.3	+	1	3969	c.3969T>A	c.(3967-3969)GAT>GAA	p.D1323E		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1323	Cadherin 13.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TCTTTGTTGATGTTTTGGAAA	0.368		NaN											0	0	0	0.007413	0	19	41									
PCDH10	57575	broad.mit.edu	37	4	134072451	134072451	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr4:134072451G>C	uc003iha.2	+	1	1982	c.1156G>C	c.(1156-1158)GAC>CAC	p.D386H	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.D386H	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	386	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		GACTGACCGCGACTCAGAGGA	0.587		NaN											0	0	0	0.00632	0	29	70									
MAML3	55534	broad.mit.edu	37	4	140651796	140651796	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr4:140651796C>T	uc003ihz.1	-	4	2845	c.2093G>A	c.(2092-2094)CGA>CAA	p.R698Q	MGST2_uc010ioi.1_Intron|MAML3_uc011chd.1_Missense_Mutation_p.R165Q	NM_018717	NP_061187	Q96JK9	MAML3_HUMAN	mastermind-like 3	698	Gln-rich.				Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity			ovary(1)	1	all_hematologic(180;0.162)					GCCTGTGGTTCGGGGAAGTCC	0.632		NaN											0	0	0	0.000602	0	4	12									
RAPGEF2	9693	broad.mit.edu	37	4	160244690	160244690	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr4:160244690G>A	uc003iqg.3	+	5	897	c.587G>A	c.(586-588)GGA>GAA	p.G196E		NM_014247	NP_055062	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor 2	196	cNMP.				cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			lung(2)|upper_aerodigestive_tract(1)|skin(1)	4	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		CTGTGCATGGGAAATAGTTTT	0.378		NaN											0	0	0	0.013537	0	12	30									
CCT5	22948	broad.mit.edu	37	5	10254942	10254942	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr5:10254942G>A	uc003jeq.2	+	3	494	c.323G>A	c.(322-324)GGA>GAA	p.G108E	CCT5_uc011cmq.1_Intron|CCT5_uc003jer.2_Missense_Mutation_p.G108E|CCT5_uc010its.2_Missense_Mutation_p.G108E|CCT5_uc011cmr.1_Intron|CCT5_uc011cms.1_Missense_Mutation_p.G70E|CCT5_uc011cmt.1_Intron	NM_012073	NP_036205	P48643	TCPE_HUMAN	chaperonin containing TCP1, subunit 5 (epsilon)	108					'de novo' posttranslational protein folding|response to virus	microtubule organizing center|nucleolus	ATP binding|unfolded protein binding			ovary(2)	2						GGAACCACAGGAGTGGTTGGT	0.418		NaN											0	0	0	0.010818	0	31	29									
TRIO	7204	broad.mit.edu	37	5	14497101	14497101	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr5:14497101G>A	uc003jff.2	+	50	8000	c.7994G>A	c.(7993-7995)GGA>GAA	p.G2665E	TRIO_uc003jfg.2_RNA	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	2665					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					TCACGGGAAGGACTCAGCAAC	0.493		NaN											0	0	0	0.008291	0	11	45									
CDH6	1004	broad.mit.edu	37	5	31317518	31317518	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr5:31317518C>G	uc003jhe.1	+	10	1875	c.1549C>G	c.(1549-1551)CCT>GCT	p.P517A	CDH6_uc003jhd.1_Missense_Mutation_p.P517A	NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	517	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						CAAGGATGACCCTTATAGTGG	0.398		NaN											0	0	0	0.009096	0	4	110									
RPL37	6167	broad.mit.edu	37	5	40834293	40834293	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr5:40834293G>A	uc003jme.1	-	3	314	c.214C>T	c.(214-216)CGC>TGC	p.R72C	SNORD72_uc003jmf.1_5'Flank	NM_000997	NP_000988	P61927	RL37_HUMAN	ribosomal protein L37	72					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	metal ion binding|protein binding|rRNA binding|structural constituent of ribosome				0		Breast(839;0.238)				CTGAATCTGCGGTATACAATT	0.398		NaN											0	0	0	0.013537	0	12	71									
HEATR7B2	133558	broad.mit.edu	37	5	41057463	41057463	+	Splice_Site	SNP	C	C	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr5:41057463C>G	uc003jmj.3	-	8	1247	c.757_splice	c.e8-1	p.S253_splice	HEATR7B2_uc003jmi.3_Intron	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2								binding			ovary(6)|central_nervous_system(2)	8						GTTTTAGGCTCTAAAGTGGAA	0.433		NaN											0	0	0	0.000602	0	5	1									
MAST4	375449	broad.mit.edu	37	5	66449324	66449324	+	Silent	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr5:66449324G>A	uc003jut.1	+	25	3065	c.2997G>A	c.(2995-2997)CTG>CTA	p.L999L	MAST4_uc003juw.2_Silent_p.L927L	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	1191	PDZ.					cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		AGGCAGGACTGAAGGCTGGAG	0.428		NaN											0	0	0	0.001168	0	5	8									
PIK3R1	5295	broad.mit.edu	37	5	67576548	67576548	+	Nonsense_Mutation	SNP	C	C	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr5:67576548C>G	uc003jva.2	+	6	1387	c.827C>G	c.(826-828)TCA>TGA	p.S276*	PIK3R1_uc003jvb.2_Nonsense_Mutation_p.S276*	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	276	Rho-GAP.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	TTCAGATTCTCAGCAGCCAGG	0.383		NaN	Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			0	0	0	0.008291	0	11	31									
GPR98	84059	broad.mit.edu	37	5	90074805	90074805	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr5:90074805G>C	uc003kju.2	+	64	13069	c.12973G>C	c.(12973-12975)GAA>CAA	p.E4325Q	GPR98_uc003kjt.2_Missense_Mutation_p.E2031Q|GPR98_uc003kjw.2_5'Flank	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	4325	Extracellular (Potential).|Calx-beta 29.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GCTCCTCTTTGAAGCAGGGGA	0.488		NaN											0	0	0	0.005443	0	28	61									
VDAC1	7416	broad.mit.edu	37	5	133326753	133326753	+	Silent	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr5:133326753C>T	uc003kyp.1	-	4	309	c.210G>A	c.(208-210)ACG>ACA	p.T70T	VDAC1_uc003kyq.1_Silent_p.T70T|VDAC1_uc003kyr.1_Silent_p.T70T	NM_003374	NP_003365	P21796	VDAC1_HUMAN	voltage-dependent anion channel 1	70	Beta stranded.				apoptosis|interspecies interaction between organisms	mitochondrial nucleoid|mitochondrial outer membrane|plasma membrane|pore complex	porin activity|protein binding|voltage-gated anion channel activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00806)|Kidney(363;0.02)		Dihydroxyaluminium(DB01375)	TCTCTGTAAACGTCAGGCCGT	0.458		NaN											0	0	0	0.010729	0	12	80									
CXCL14	9547	broad.mit.edu	37	5	134910273	134910273	+	Silent	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr5:134910273G>A	uc003lay.2	-	3	774	c.309C>T	c.(307-309)AAC>AAT	p.N103N		NM_004887	NP_004878	O95715	CXL14_HUMAN	small inducible cytokine B14 precursor	103					cell-cell signaling|chemotaxis|immune response|signal transduction	extracellular space|Golgi apparatus	chemokine activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TGCGCTTCTCGTTCCAGGCGT	0.493		NaN											0	0	0	0.006214	0	9	20									
PCDHGA2	56113	broad.mit.edu	37	5	140718701	140718701	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr5:140718701G>C	uc003ljk.1	+	1	348	c.163G>C	c.(163-165)GAG>CAG	p.E55Q	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Missense_Mutation_p.E55Q	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	55	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTTGGGTTTGGAGCCCCTGGC	0.617		NaN									OREG0016854	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010504	0	19	42									
PCDHGA8	9708	broad.mit.edu	37	5	140774463	140774463	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr5:140774463G>A	uc003lkd.1	+	1	2981	c.2083G>A	c.(2083-2085)GTG>ATG	p.V695M	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkb.3_Missense_Mutation_p.V695M	NM_032088	NP_114477	Q9Y5G5	PCDG8_HUMAN	protocadherin gamma subfamily A, 8 isoform 1	695	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTATCTCGTGGTGGCAGTGGC	0.607		NaN											0	0	0	0.006214	0	7	22									
PCDH12	51294	broad.mit.edu	37	5	141336156	141336156	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr5:141336156C>T	uc003llx.2	-	1	2472	c.1261G>A	c.(1261-1263)GAG>AAG	p.E421K		NM_016580	NP_057664	Q9NPG4	PCD12_HUMAN	protocadherin 12 precursor	421	Cadherin 4.|Extracellular (Potential).				neuron recognition	integral to plasma membrane	calcium ion binding			ovary(3)	3		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCCACTGCTCTCTGTCCAGT	0.498		NaN											0	0	0	0.005524	0	38	78									
TIMD4	91937	broad.mit.edu	37	5	156381553	156381553	+	Silent	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr5:156381553C>T	uc003lwh.2	-	2	330	c.273G>A	c.(271-273)CCG>CCA	p.P91P	TIMD4_uc010jii.2_Silent_p.P91P	NM_138379	NP_612388	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain	91	Ig-like V-type.|Extracellular (Potential).					integral to membrane				ovary(2)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CATCACCTCTCGGGATAGTCC	0.517		NaN											0	0	0	0.008871	0	20	39									
CYFIP2	26999	broad.mit.edu	37	5	156788517	156788517	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr5:156788517G>A	uc003lwq.2	+	28	3088	c.2950G>A	c.(2950-2952)GAG>AAG	p.E984K	CYFIP2_uc011ddn.1_Missense_Mutation_p.E958K|CYFIP2_uc011ddo.1_Missense_Mutation_p.E788K|CYFIP2_uc003lwr.2_Missense_Mutation_p.E984K|CYFIP2_uc003lws.2_Missense_Mutation_p.E984K|CYFIP2_uc003lwt.2_Missense_Mutation_p.E887K|CYFIP2_uc011ddp.1_Missense_Mutation_p.E718K	NM_001037333	NP_001032410	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	1009					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding				0	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GGACATCATTGAGTACGCAGA	0.542		NaN											0	0	0	0.013537	0	11	19									
EIF4E1B	253314	broad.mit.edu	37	5	176070159	176070159	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr5:176070159C>T	uc010jkf.1	+	4	676	c.92C>T	c.(91-93)ACA>ATA	p.T31I		NM_001099408	NP_001092878	A6NMX2	I4E1B_HUMAN	eukaryotic translation initiation factor 4E	31					regulation of translation	cytoplasm|mRNA cap binding complex	translation initiation factor activity				0	all_cancers(89;0.00185)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.00498)|all_neural(177;0.0212)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGGACGCCCACAGGAGAAAAG	0.498		NaN											0	0	0	0.008871	0	19	26									
CNOT6	57472	broad.mit.edu	37	5	180000991	180000991	+	Missense_Mutation	SNP	A	A	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr5:180000991A>C	uc003mlx.2	+	12	1814	c.1465A>C	c.(1465-1467)ATA>CTA	p.I489L	CNOT6_uc010jld.2_Missense_Mutation_p.I489L|CNOT6_uc010jle.2_Missense_Mutation_p.I484L	NM_015455	NP_056270	Q9ULM6	CNOT6_HUMAN	CCR4-NOT transcription complex, subunit 6	489					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	exonuclease activity|metal ion binding|protein binding|RNA binding				0	all_cancers(89;3.3e-05)|all_epithelial(37;7.38e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00543)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	OV - Ovarian serous cystadenocarcinoma(192;0.023)		TTTTCAGGGTATAATAGACTA	0.418		NaN											0	0	0	0.003163	0	15	33									
GMDS	2762	broad.mit.edu	37	6	1726704	1726704	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr6:1726704C>G	uc003mtq.2	-	9	1123	c.933G>C	c.(931-933)GAG>GAC	p.E311D		NM_001500	NP_001491	O60547	GMDS_HUMAN	GDP-mannose 4,6-dehydratase	311					'de novo' GDP-L-fucose biosynthetic process|GDP-mannose metabolic process|leukocyte cell-cell adhesion		coenzyme binding|GDP-mannose 4,6-dehydratase activity			central_nervous_system(1)	1	Ovarian(93;0.0733)	all_cancers(2;7.64e-19)|all_epithelial(2;3.05e-16)|Colorectal(2;0.00414)|all_hematologic(90;0.00997)|all_lung(73;0.0141)|Lung NSC(90;0.0802)		Epithelial(2;7.61e-06)|all cancers(2;0.000111)|STAD - Stomach adenocarcinoma(2;0.000231)|Colorectal(2;0.00445)|COAD - Colon adenocarcinoma(2;0.0125)|OV - Ovarian serous cystadenocarcinoma(45;0.0563)		CTTTGCCGGTCTCTTTACATC	0.493		NaN											0	0	0	0.014323	0	19	95									
GMDS	2762	broad.mit.edu	37	6	1726724	1726724	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr6:1726724C>T	uc003mtq.2	-	9	1103	c.913G>A	c.(913-915)GAA>AAA	p.E305K		NM_001500	NP_001491	O60547	GMDS_HUMAN	GDP-mannose 4,6-dehydratase	305					'de novo' GDP-L-fucose biosynthetic process|GDP-mannose metabolic process|leukocyte cell-cell adhesion		coenzyme binding|GDP-mannose 4,6-dehydratase activity			central_nervous_system(1)	1	Ovarian(93;0.0733)	all_cancers(2;7.64e-19)|all_epithelial(2;3.05e-16)|Colorectal(2;0.00414)|all_hematologic(90;0.00997)|all_lung(73;0.0141)|Lung NSC(90;0.0802)		Epithelial(2;7.61e-06)|all cancers(2;0.000111)|STAD - Stomach adenocarcinoma(2;0.000231)|Colorectal(2;0.00445)|COAD - Colon adenocarcinoma(2;0.0125)|OV - Ovarian serous cystadenocarcinoma(45;0.0563)		CTGCCCACTTCATTTTCATTC	0.493		NaN											0	0	0	0.006122	0	18	90									
DSP	1832	broad.mit.edu	37	6	7584100	7584100	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr6:7584100C>T	uc003mxp.1	+	24	6884	c.6605C>T	c.(6604-6606)TCA>TTA	p.S2202L	DSP_uc003mxq.1_Missense_Mutation_p.S1603L	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	2202	Plectin 6.|Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		CTCTTGCTTTCAGTACAGAAG	0.458		NaN											0	0	0	0.006999	0	38	52									
HIST1H3B	8358	broad.mit.edu	37	6	26031997	26031997	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr6:26031997C>T	uc003nfs.1	-	1	292	c.292G>A	c.(292-294)GAG>AAG	p.E98K		NM_003537	NP_003528	P68431	H31_HUMAN	histone cluster 1, H3b	98					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(2)	2						AAGTAGGCCTCACAAGCCTCC	0.567		NaN											0	0	0	0.008871	0	21	65									
HIST1H1C	3006	broad.mit.edu	37	6	26056393	26056393	+	Silent	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr6:26056393C>T	uc003nfw.2	-	1	307	c.264G>A	c.(262-264)GTG>GTA	p.V88V		NM_005319	NP_005310	P16403	H12_HUMAN	histone cluster 1, H1c	88	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(3)|skin(2)	5						TGCCCTTGCTCACCAGGCTCT	0.532		NaN											0	0	0	0.013726	0	34	129									
BTN1A1	696	broad.mit.edu	37	6	26501534	26501534	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr6:26501534C>G	uc003nif.3	+	1	40	c.20C>G	c.(19-21)TCC>TGC	p.S7C		NM_001732	NP_001723	Q13410	BT1A1_HUMAN	butyrophilin, subfamily 1, member A1 precursor	7						extracellular region|integral to plasma membrane	receptor activity			ovary(1)|skin(1)	2						TTCCCAAGCTCCGGTCTCCCC	0.522		NaN											0	0	0	0.010771	0	40	55									
HSPA1A	3303	broad.mit.edu	37	6	31783561	31783561	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr6:31783561G>A	uc003nxj.2	+	1	271	c.28G>A	c.(28-30)GAC>AAC	p.D10N	HSPA1L_uc003nxh.2_5'Flank|HSPA1L_uc010jte.2_5'Flank|HSPA1A_uc011doj.1_Missense_Mutation_p.D10N|HSPA1A_uc003nxi.1_Missense_Mutation_p.D10N|uc011dok.1_RNA	NM_005345	NP_005336	P08107	HSP71_HUMAN	heat shock 70kDa protein 1A	10					anti-apoptosis|mRNA catabolic process|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of inclusion body assembly|protein refolding|response to unfolded protein	cytosol|endoplasmic reticulum|inclusion body|mitochondrion|nuclear speck|perinuclear region of cytoplasm|ribonucleoprotein complex	ATP binding|protein binding involved in protein folding|protein N-terminus binding|receptor activity|ubiquitin protein ligase binding|unfolded protein binding			ovary(1)	1						GATCGGCATCGACCTGGGCAC	0.647		NaN											0	0	0	0.01441	0	40	34									
HLA-DQA1	3117	broad.mit.edu	37	6	32609935	32609935	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr6:32609935A>G	uc003obr.2	+	3	571	c.518A>G	c.(517-519)AAG>AGG	p.K173R	HLA-DQA1_uc003obs.2_RNA|HLA-DQA1_uc003obt.1_Missense_Mutation_p.K173R|HLA-DQA1_uc003obu.2_5'Flank	NM_002122	NP_002113	P01909	DQA1_HUMAN	major histocompatibility complex, class II, DQ	172	Ig-like C1-type.|Alpha-2.|Extracellular (Potential).				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to plasma membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity				0						TCCTTCTTCAAGATCAGTTAC	0.512		NaN											0	0	0	0.012319	0	18	67									
HLA-DQA2	3118	broad.mit.edu	37	6	32713754	32713754	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr6:32713754A>G	uc003obx.2	+	3	576	c.518A>G	c.(517-519)AAG>AGG	p.K173R		NM_020056	NP_064440	P01906	DQA2_HUMAN	major histocompatibility complex, class II, DQ	173	Alpha-2.|Extracellular (Potential).|Ig-like C1-type.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to plasma membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity				0					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TCCTTCTTCAAGATCAGTTAC	0.517		NaN											0	0	0	0.007291	0	26	182									
ZBTB9	221504	broad.mit.edu	37	6	33423781	33423781	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr6:33423781C>T	uc003oeq.2	+	2	1172	c.904C>T	c.(904-906)CAG>TAG	p.Q302*		NM_152735	NP_689948	Q96C00	ZBTB9_HUMAN	zinc finger and BTB domain containing 9	302	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AAGCGGAACTCAGCCTGGAGG	0.547		NaN											0	0	0	0.003954	0	26	61									
CCND3	896	broad.mit.edu	37	6	41908144	41908144	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr6:41908144G>C	uc003orn.2	-	2	543	c.378C>G	c.(376-378)ATC>ATG	p.I126M	CCND3_uc003orp.2_Missense_Mutation_p.I45M|CCND3_uc011duk.1_Intron|CCND3_uc011dum.1_Missense_Mutation_p.I45M|CCND3_uc003orm.2_Missense_Mutation_p.I76M|CCND3_uc003oro.2_Intron|CCND3_uc011dul.1_Intron	NM_001760	NP_001751	P30281	CCND3_HUMAN	cyclin D3 isoform 2	126	Cyclin N-terminal.				cell division|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation	cyclin-dependent protein kinase holoenzyme complex|cytoplasm|membrane|nucleus	protein kinase binding				0	Colorectal(47;0.121)		Epithelial(12;0.000178)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			GGTCGGTGTAGATGCACAGTT	0.617		NaN	T	IGH@	MM								0	0	0	0.00632	0	27	78									
BEND6	221336	broad.mit.edu	37	6	56880031	56880031	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr6:56880031G>A	uc010kab.2	+	4	985	c.399G>A	c.(397-399)TGG>TGA	p.W133*	BEND6_uc003pdi.3_Nonsense_Mutation_p.W35*	NM_152731	NP_689944	Q5SZJ8	BEND6_HUMAN	BEN domain containing 6	133											0						CCACCCTCTGGAGAGCAACAA	0.478		NaN											0	0	0	0.007291	0	31	49									
OGFRL1	79627	broad.mit.edu	37	6	72011597	72011597	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr6:72011597G>C	uc003pfx.1	+	7	1364	c.1201G>C	c.(1201-1203)GAG>CAG	p.E401Q		NM_024576	NP_078852	Q5TC84	OGRL1_HUMAN	opioid growth factor receptor-like 1	401						membrane	receptor activity				0						CAGTAATGCTGAGAACATGAA	0.458		NaN											0	0	0	0.007291	0	28	42									
HACE1	57531	broad.mit.edu	37	6	105198288	105198288	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr6:105198288G>C	uc003pqu.1	-	20	2548	c.2271C>G	c.(2269-2271)ATC>ATG	p.I757M	HACE1_uc010kcy.1_Missense_Mutation_p.I239M|HACE1_uc010kcz.1_Missense_Mutation_p.I542M|HACE1_uc010kcx.1_Missense_Mutation_p.I166M|HACE1_uc003pqt.1_Missense_Mutation_p.I410M	NM_020771	NP_065822	Q8IYU2	HACE1_HUMAN	HECT domain and ankyrin repeat containing, E3	757	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	endoplasmic reticulum	ubiquitin-protein ligase activity			ovary(5)|lung(2)	7		all_cancers(87;6.89e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0216)|Colorectal(196;0.202)		BRCA - Breast invasive adenocarcinoma(108;0.122)|Epithelial(106;0.204)		AAAAAGCATTGATCTGAGGCT	0.383		NaN											0	0	0	0.000602	0	4	18									
UTRN	7402	broad.mit.edu	37	6	144860468	144860468	+	Silent	SNP	C	C	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr6:144860468C>G	uc003qkt.2	+	44	6500	c.6408C>G	c.(6406-6408)CTC>CTG	p.L2136L		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	2136					muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		CTGAAAAACTCAAATGGCTGA	0.348		NaN											0	0	0	0.013537	0	13	32									
KATNA1	11104	broad.mit.edu	37	6	149959681	149959681	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr6:149959681C>G	uc003qmr.1	-	1	48	c.3G>C	c.(1-3)ATG>ATC	p.M1I	KATNA1_uc003qms.2_Missense_Mutation_p.M1I|KATNA1_uc003qmt.2_Missense_Mutation_p.M1I|KATNA1_uc011eed.1_Missense_Mutation_p.M1I	NM_007044	NP_008975	O75449	KTNA1_HUMAN	katanin p60 subunit A 1	1	Interaction with microtubule.|Interaction with KATNB1.				cell division|interphase of mitotic cell cycle|mitosis	microtubule|microtubule organizing center|spindle pole	ATP binding|microtubule binding|microtubule-severing ATPase activity|protein heterodimerization activity			skin(1)	1		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;2.95e-12)|GBM - Glioblastoma multiforme(68;0.173)		TAAGAAGACTCATGTTCAACT	0.333		NaN											0	0	0	0.005443	0	27	124									
NUP43	348995	broad.mit.edu	37	6	150048189	150048189	+	Silent	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr6:150048189C>T	uc003qmz.2	-	8	1116	c.1059G>A	c.(1057-1059)GTG>GTA	p.V353V	NUP43_uc003qmx.3_RNA|NUP43_uc011eee.1_RNA|NUP43_uc011eef.1_Silent_p.V257V	NM_198887	NP_942590	Q8NFH3	NUP43_HUMAN	nucleoporin 43kDa	353					carbohydrate metabolic process|cell division|chromosome segregation|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	protein binding			upper_aerodigestive_tract(1)	1		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;4.71e-13)|GBM - Glioblastoma multiforme(68;0.101)		CCAAAGTGTTCACAGACAGAG	0.398		NaN											0	0	0	0.00333	0	23	21									
C7orf28B	221960	broad.mit.edu	37	7	6840699	6840699	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr7:6840699C>T	uc003sqx.1	-	14	1306	c.1273G>A	c.(1273-1275)GAA>AAA	p.E425K	C7orf28B_uc011jxd.1_Missense_Mutation_p.E282K	NM_198097	NP_932765	P86791	CCZ1_HUMAN	hypothetical protein LOC221960	425						lysosomal membrane					0		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)		TCCTCATCTTCATCCACTCTG	0.438		NaN											0	0	0	0.004878	0	20	82									
RPA3	6119	broad.mit.edu	37	7	7678736	7678736	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr7:7678736C>T	uc003sri.2	-	6	1311	c.139G>A	c.(139-141)GAA>AAA	p.E47K	RPA3_uc003srh.2_Missense_Mutation_p.E8K	NM_002947	NP_002938	P35244	RFA3_HUMAN	replication protein A3, 14kDa	47					cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	cytoplasm|DNA replication factor A complex|nucleoplasm	protein binding|single-stranded DNA binding			large_intestine(1)	1		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.202)		TTTTTTCCTTCTCCATCTGAA	0.299		NaN						Direct_reversal_of_damage|NER					0	0	0	0.004482	0	7	39									
RPA3	6119	broad.mit.edu	37	7	7678739	7678739	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr7:7678739C>A	uc003sri.2	-	6	1308	c.136G>T	c.(136-138)GGA>TGA	p.G46*	RPA3_uc003srh.2_Nonsense_Mutation_p.G7*	NM_002947	NP_002938	P35244	RFA3_HUMAN	replication protein A3, 14kDa	46					cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	cytoplasm|DNA replication factor A complex|nucleoplasm	protein binding|single-stranded DNA binding			large_intestine(1)	1		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.202)		TTTCCTTCTCCATCTGAAAGA	0.299		NaN						Direct_reversal_of_damage|NER					1	0	1.06961e-07	0.00308	1.1241e-07	6	39									
C7orf30	115416	broad.mit.edu	37	7	23347497	23347497	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr7:23347497T>C	uc003swd.1	+	3	478	c.446T>C	c.(445-447)CTG>CCG	p.L149P	C7orf30_uc003swe.2_5'Flank	NM_138446	NP_612455	Q96EH3	CG030_HUMAN	hypothetical protein LOC115416	149						mitochondrion					0			GBM - Glioblastoma multiforme(13;0.154)			TACAAACACCTGAAATGTAAA	0.418		NaN											0	0	0	0.004672	0	3	79									
AVL9	23080	broad.mit.edu	37	7	32598734	32598734	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr7:32598734G>A	uc003tcv.1	+	10	1019	c.873G>A	c.(871-873)ATG>ATA	p.M291I	AVL9_uc011kai.1_Missense_Mutation_p.M291I|AVL9_uc010kwj.1_Missense_Mutation_p.M132I	NM_015060	NP_055875	Q8NBF6	AVL9_HUMAN	AVL9 homolog (S. cerevisiase)	291						integral to membrane					0						ATGCTGCCATGAAGACTGAGG	0.463		NaN											0	0	0	0.010729	0	10	18									
RP9	6100	broad.mit.edu	37	7	33136118	33136118	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr7:33136118C>G	uc003tdm.2	-	5	472	c.454G>C	c.(454-456)GAA>CAA	p.E152Q		NM_203288	NP_976033	Q8TA86	RP9_HUMAN	retinitis pigmentosa 9	152	PIM1-binding (By similarity).				RNA splicing	nucleus	nucleic acid binding|protein binding|zinc ion binding				0			GBM - Glioblastoma multiforme(11;0.0403)			ACGTCCTTTTCATGTCGTTTA	0.383		NaN											0	0	0	0.013537	0	11	41									
ABCA13	154664	broad.mit.edu	37	7	48318168	48318168	+	Silent	SNP	T	T	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr7:48318168T>C	uc003toq.2	+	18	7402	c.7377T>C	c.(7375-7377)TTT>TTC	p.F2459F	ABCA13_uc010kys.1_5'Flank	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	2459					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TGCTTTTCTTTATAAATAATT	0.343		NaN											0	0	0	0.01441	0	48	79									
POM121L12	285877	broad.mit.edu	37	7	53103750	53103750	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr7:53103750A>G	uc003tpz.2	+	1	402	c.386A>G	c.(385-387)AAC>AGC	p.N129S		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	129											0						CGTGCCTGGAACCCAGGACGG	0.642		NaN											0	0	0	0.00333	0	20	33									
ZNF479	90827	broad.mit.edu	37	7	57188660	57188660	+	Silent	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr7:57188660G>A	uc010kzo.2	-	5	733	c.462C>T	c.(460-462)AAC>AAT	p.N154N		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	154					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			GAAATATTTTGTTTTGGGTAG	0.289		NaN											0	0	0	0.003954	0	21	49									
WBSCR28	135886	broad.mit.edu	37	7	73275587	73275587	+	Silent	SNP	C	C	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr7:73275587C>G	uc003tzk.2	+	1	99	c.63C>G	c.(61-63)CTC>CTG	p.L21L	RFC2_uc011kfa.1_Intron|WBSCR28_uc003tzl.2_5'UTR	NM_182504	NP_872310	Q6UE05	WBS28_HUMAN	hypothetical protein LOC135886	21						integral to membrane				breast(1)	1		Lung NSC(55;0.159)				TTACGAGGCTCTCAGTGCTGG	0.642		NaN											0	0	0	0.010729	0	12	20									
HGF	3082	broad.mit.edu	37	7	81355231	81355231	+	Silent	SNP	T	T	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr7:81355231T>C	uc003uhl.2	-	9	1308	c.1143A>G	c.(1141-1143)CCA>CCG	p.P381P	HGF_uc003uhm.2_Silent_p.P376P	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	381	Kringle 3.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4						TATCACAGTTTGGAATTTGGG	0.448		NaN											0	0	0	0.00245	0	14	79									
CROT	54677	broad.mit.edu	37	7	86988563	86988563	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr7:86988563G>A	uc003uit.2	+	4	402	c.157G>A	c.(157-159)GAA>AAA	p.E53K	CROT_uc003uis.3_Missense_Mutation_p.E53K|CROT_uc003uiu.2_Missense_Mutation_p.E81K	NM_021151	NP_066974	Q9UKG9	OCTC_HUMAN	peroxisomal carnitine O-octanoyltransferase	53					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|transport	peroxisomal matrix	carnitine O-octanoyltransferase activity			ovary(2)|lung(1)	3	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)				L-Carnitine(DB00583)	GAAAACTGAAGAAATAGTTCA	0.308		NaN											0	0	0	0.00308	0	8	41									
AKAP9	10142	broad.mit.edu	37	7	91631551	91631551	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr7:91631551G>A	uc003ulg.2	+	8	2545	c.2320G>A	c.(2320-2322)GAA>AAA	p.E774K	AKAP9_uc003ule.2_Missense_Mutation_p.E786K|AKAP9_uc003ulf.2_Missense_Mutation_p.E774K|AKAP9_uc003uli.2_Missense_Mutation_p.E399K	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	786	Glu-rich.|Potential.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TGCACAACTTGAAGCAGAGAA	0.303		NaN	T	BRAF	papillary thyroid								0	0	0	0.013537	0	12	68									
CYP3A7	1551	broad.mit.edu	37	7	99312307	99312307	+	Splice_Site	SNP	T	T	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr7:99312307T>C	uc003uru.2	-	8	776	c.671_splice	c.e8-1	p.K224_splice	ZNF498_uc003urn.2_Intron|CYP3A5_uc003urs.2_Intron|CYP3A5_uc010lgg.2_Intron	NM_000765	NP_000756	P24462	CP3A7_HUMAN	cytochrome P450, family 3, subfamily A,						xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)	1	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)					GAAAGACTTCTGTAGAAAAAA	0.303		NaN											0	0	0	0.003954	0	25	54									
GIGYF1	64599	broad.mit.edu	37	7	100285422	100285422	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr7:100285422C>T	uc003uwg.1	-	3	1259	c.250G>A	c.(250-252)GAG>AAG	p.E84K		NM_022574	NP_072096	O75420	PERQ1_HUMAN	PERQ amino acid rich, with GYF domain 1	84										large_intestine(1)|central_nervous_system(1)	2	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					TGTTCCTCCTCAGTCAGCGGC	0.687		NaN											0	0	0	0.005443	0	23	62									
RELN	5649	broad.mit.edu	37	7	103194142	103194142	+	Missense_Mutation	SNP	G	G	C	rs141509094		TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr7:103194142G>C	uc003vca.2	-	39	6094	c.5934C>G	c.(5932-5934)ATC>ATG	p.I1978M	RELN_uc010liz.2_Missense_Mutation_p.I1978M	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1978					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AATAAAGACCGATGTTACCAC	0.363		NaN											0	0	0	0.003163	0	14	24									
PTN	5764	broad.mit.edu	37	7	136935980	136935980	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr7:136935980G>A	uc003vtq.2	-	4	811	c.448C>T	c.(448-450)CAA>TAA	p.Q150*	PTN_uc010lmx.2_Nonsense_Mutation_p.Q150*|PTN_uc003vtr.1_Nonsense_Mutation_p.Q150*	NM_002825	NP_002816	P21246	PTN_HUMAN	pleiotrophin	150					nervous system development|positive regulation of cell division|positive regulation of cell proliferation|transmembrane receptor protein tyrosine phosphatase signaling pathway	endoplasmic reticulum|extracellular space	growth factor activity|heparin binding|protein phosphatase inhibitor activity			upper_aerodigestive_tract(1)|pancreas(1)	2						GACTTACCTTGAGGTTTGGGC	0.458		NaN											0	0	0	0.01441	0	45	125									
DENND2A	27147	broad.mit.edu	37	7	140301532	140301532	+	Silent	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr7:140301532C>T	uc010lnj.2	-	1	811	c.666G>A	c.(664-666)CTG>CTA	p.L222L	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Silent_p.L222L|DENND2A_uc003vvw.2_Silent_p.L222L|DENND2A_uc003vvx.2_Silent_p.L222L	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	222										ovary(3)|breast(1)	4	Melanoma(164;0.00956)					CCCTGCCTTCCAGGTCCGAGG	0.637		NaN											0	0	0	0.01441	0	50	130									
SSPO	23145	broad.mit.edu	37	7	149476138	149476138	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr7:149476138G>C	uc010lpk.2	+	8	1016	c.1016G>C	c.(1015-1017)GGA>GCA	p.G339A	SSPO_uc010lpl.1_Intron	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	339	VWFD 1.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GAGCCAGGCGGAGGGCTGGCC	0.637		NaN											0	0	0	0.013537	0	12	23									
RP1L1	94137	broad.mit.edu	37	8	10466760	10466760	+	Silent	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr8:10466760G>A	uc003wtc.2	-	4	5077	c.4848C>T	c.(4846-4848)CTC>CTT	p.L1616L		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1616					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		AGAAGGCCGAGAGGTTTCGCA	0.706		NaN											0	0	0	0.001855	0	13	12									
PCM1	5108	broad.mit.edu	37	8	17813004	17813004	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr8:17813004G>C	uc003wyi.3	+	10	1736	c.1314G>C	c.(1312-1314)CAG>CAC	p.Q438H	PCM1_uc011kyh.1_Missense_Mutation_p.Q438H|PCM1_uc003wyj.3_Missense_Mutation_p.Q438H|PCM1_uc003wyh.2_Missense_Mutation_p.Q477H|PCM1_uc010lta.1_Missense_Mutation_p.Q477H	NM_006197	NP_006188	Q15154	PCM1_HUMAN	pericentriolar material 1	438					centrosome organization|cilium assembly|G2/M transition of mitotic cell cycle|interkinetic nuclear migration|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome	centriolar satellite|cytosol|nuclear membrane|pericentriolar material	identical protein binding		PCM1/JAK2(30)	haematopoietic_and_lymphoid_tissue(30)|breast(4)|ovary(2)	36				Colorectal(111;0.0789)		GTGTCGATCAGAGAAGTACTT	0.433		NaN	T	RET|JAK2	papillary thyroid|CML|MPD								0	0	0	0.001168	0	6	6									
TRPA1	8989	broad.mit.edu	37	8	72987642	72987642	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr8:72987642C>T	uc003xza.2	-	1	178	c.3G>A	c.(1-3)ATG>ATA	p.M1I		NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	1	Cytoplasmic (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	GGCTGCGCTTCATTGACCCCA	0.657		NaN											0	0	0	0.01441	0	49	54									
COL14A1	7373	broad.mit.edu	37	8	121170472	121170472	+	Silent	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr8:121170472G>A	uc003yox.2	+	3	457	c.192G>A	c.(190-192)GTG>GTA	p.V64V		NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	64	Fibronectin type-III 1.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			AACTTCTTGTGACTCCAACTT	0.368		NaN											0	0	0	0.004482	0	8	42									
FER1L6	654463	broad.mit.edu	37	8	125035748	125035748	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr8:125035748C>T	uc003yqw.2	+	18	2404	c.2198C>T	c.(2197-2199)GCC>GTC	p.A733V	uc003yqx.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	733	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GTGGCCTATGCCCGCATCGCC	0.527		NaN											0	0	0	0.001168	0	4	100									
TG	7038	broad.mit.edu	37	8	134145801	134145801	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr8:134145801G>C	uc003ytw.2	+	47	8126	c.8085G>C	c.(8083-8085)GAG>GAC	p.E2695D	TG_uc010mdw.2_Missense_Mutation_p.E1454D|TG_uc011ljb.1_Missense_Mutation_p.E1064D|TG_uc011ljc.1_Missense_Mutation_p.E828D	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	2695					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CTGGTGGAGAGAACTACAAGG	0.522		NaN											0	0	0	0.003755	0	37	54									
SLC45A4	57210	broad.mit.edu	37	8	142228412	142228412	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr8:142228412C>T	uc003ywd.1	-	4	1482	c.1174G>A	c.(1174-1176)GCC>ACC	p.A392T	SLC45A4_uc003ywc.1_Missense_Mutation_p.A392T|SLC45A4_uc010meq.1_Missense_Mutation_p.A390T	NM_001080431	NP_001073900	Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	443					transport	integral to membrane				ovary(2)	2	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			ACGGCGTTGGCGCGCCGGTAG	0.692		NaN											0	0	0	0.000602	0	5	68									
BAI1	575	broad.mit.edu	37	8	143603352	143603352	+	Silent	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr8:143603352C>T	uc003ywm.2	+	20	3234	c.3051C>T	c.(3049-3051)TTC>TTT	p.F1017F		NM_001702	NP_001693	O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	1017	Helical; Name=3; (Potential).				axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|pancreas(1)	8	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					TGGCCGCCTTCCTGCACTTCT	0.687		NaN											0	0	0	0.004672	0	3	14									
ZNF251	90987	broad.mit.edu	37	8	145947781	145947781	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr8:145947781C>T	uc003zdv.3	-	5	1520	c.1264G>A	c.(1264-1266)GAA>AAA	p.E422K		NM_138367	NP_612376	Q9BRH9	ZN251_HUMAN	zinc finger protein 251	422	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;7.54e-38)|all cancers(56;6.19e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.198)		CTTACGTGTTCAGTAAGATGA	0.448		NaN											0	0	0	0.01441	0	58	68									
DOCK8	81704	broad.mit.edu	37	9	463637	463637	+	Silent	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr9:463637G>A	uc003zgf.2	+	47	6301	c.6189G>A	c.(6187-6189)CGG>CGA	p.R2063R	DOCK8_uc010mgu.2_Silent_p.R1365R|DOCK8_uc010mgv.2_Silent_p.R1963R|DOCK8_uc003zgk.2_Silent_p.R1521R	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	2063					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		TGATCGAGCGGAAAATTCCAG	0.458		NaN											0	0	0	0.010729	0	5	61									
RANBP6	26953	broad.mit.edu	37	9	6015339	6015339	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr9:6015339G>C	uc003zjr.2	-	1	280	c.269C>G	c.(268-270)CCT>CGT	p.P90R	RANBP6_uc011lmf.1_Intron|RANBP6_uc003zjs.2_Intron	NM_012416	NP_036548	O60518	RNBP6_HUMAN	RAN binding protein 6	90					protein transport	cytoplasm|nucleus	binding			ovary(3)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)		AACATCAGCAGGCAGATTTGG	0.433		NaN											0	0	0	0.00874	0	41	97									
DENND4C	55667	broad.mit.edu	37	9	19324474	19324474	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr9:19324474G>A	uc003znq.2	+	9	1247	c.1214G>A	c.(1213-1215)GGA>GAA	p.G405E	DENND4C_uc011lnc.1_Intron	NM_017925	NP_060395	Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	405						integral to membrane				ovary(1)|skin(1)	2						AAAGATACTGGATTAGCATTT	0.303		NaN											0	0	0	0.01441	0	83	251									
FOXB2	442425	broad.mit.edu	37	9	79634833	79634833	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr9:79634833C>T	uc004ako.1	+	1	263	c.263C>T	c.(262-264)GCG>GTG	p.A88V		NM_001013735	NP_001013757	Q5VYV0	FOXB2_HUMAN	forkhead box B2	88	Fork-head.				brain development|embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						AGCTTCTGGGCGCTGCACCCC	0.642		NaN											0	0	0	0.01441	0	55	14									
PTCH1	5727	broad.mit.edu	37	9	98229643	98229643	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr9:98229643C>T	uc004avk.3	-	15	2503	c.2315G>A	c.(2314-2316)AGA>AAA	p.R772K	PTCH1_uc010mro.2_Missense_Mutation_p.R621K|PTCH1_uc010mrp.2_Missense_Mutation_p.R621K|PTCH1_uc010mrq.2_Missense_Mutation_p.R621K|PTCH1_uc004avl.3_Missense_Mutation_p.R621K|PTCH1_uc010mrr.2_Missense_Mutation_p.R706K|PTCH1_uc004avm.3_Missense_Mutation_p.R771K	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	772	Extracellular (Potential).				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				CAGCCCGTCTCTCACTCGGGT	0.478		NaN							Basal_Cell_Nevus_syndrome				0	0	0	0.011902	0	43	16									
RXRA	6256	broad.mit.edu	37	9	137293649	137293649	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08			T	C	T	T		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr9:137293649T>C	uc004cfb.2	+	2	362	c.200T>C	c.(199-201)GTC>GCC	p.V67A	RXRA_uc004cfa.1_Silent_p.G117G	NM_002957	NP_002948	P19793	RXRA_HUMAN	retinoid X receptor, alpha	67	Modulating (By similarity).				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	CCTTTCTCGGTCATCAGCTCC	0.642		NaN											0	0	0	0.004672	0	3	117									
STS	412	broad.mit.edu	37	X	7268123	7268123	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chrX:7268123G>A	uc004cry.3	+	10	1818	c.1573G>A	c.(1573-1575)GAA>AAA	p.E525K		NM_000351	NP_000342	P08842	STS_HUMAN	steryl-sulfatase precursor	525	Lumenal.				female pregnancy|steroid catabolic process	endoplasmic reticulum membrane|endosome|Golgi apparatus|integral to membrane|lysosome|microsome|plasma membrane	metal ion binding|steryl-sulfatase activity			central_nervous_system(1)	1		Colorectal(8;0.0136)|Medulloblastoma(8;0.184)			Estrone(DB00655)	CCGGTTTTATGAAATCCTCAA	0.498		NaN							Ichthyosis				0	0	0	0.003163	0	15	10									
TAB3	257397	broad.mit.edu	37	X	30873150	30873150	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chrX:30873150C>G	uc004dcj.2	-	6	1295	c.632G>C	c.(631-633)AGA>ACA	p.R211T	TAB3_uc004dck.2_Missense_Mutation_p.R211T|TAB3_uc010ngl.2_Missense_Mutation_p.R211T	NM_152787	NP_690000	Q8N5C8	TAB3_HUMAN	mitogen-activated protein kinase kinase kinase 7	211	Pro-rich.				activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein binding|zinc ion binding			ovary(1)	1						TTGTAAAGCTCTTGGTACAGT	0.423		NaN											0	0	0	0.006122	0	18	13									
ZMYM3	9203	broad.mit.edu	37	X	70472591	70472591	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chrX:70472591G>A	uc004dzh.1	-	2	602	c.515C>T	c.(514-516)TCC>TTC	p.S172F	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Missense_Mutation_p.S172F|ZMYM3_uc004dzj.1_Missense_Mutation_p.S172F|ZMYM3_uc011mpu.1_5'Flank|ZMYM3_uc004dzk.3_Missense_Mutation_p.S172F|ZMYM3_uc004dzl.3_Missense_Mutation_p.S172F|ZMYM3_uc004dzm.3_Missense_Mutation_p.S172F	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	172					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					CTGCCCAGGGGAGCCCCTTCT	0.577		NaN											0	0	0	0.00632	0	25	7									
NONO	4841	broad.mit.edu	37	X	70514379	70514379	+	Splice_Site	SNP	G	G	A			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chrX:70514379G>A	uc004dzo.2	+	6	1360	c.650_splice	c.e6+1	p.T217_splice	BCYRN1_uc011mpt.1_Intron|NONO_uc004dzn.2_Splice_Site_p.T217_splice|NONO_uc004dzp.2_Splice_Site_p.T217_splice|NONO_uc011mpv.1_Splice_Site_p.T128_splice|NONO_uc004dzq.2_Splice_Site_p.T86_splice	NM_001145408	NP_001138880	Q15233	NONO_HUMAN	non-POU domain containing, octamer-binding						DNA recombination|DNA repair|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nuclear matrix|paraspeckles	DNA binding|identical protein binding|nucleotide binding|RNA binding		NONO/TFE3(2)	ovary(2)|kidney(2)	4	Renal(35;0.156)					TGCTAACCACGTAAGTGAGGG	0.473		NaN	T	TFE3	papillary renal cancer								0	0	0	0.004482	0	9	1									
SYNC	81493	broad.mit.edu	37	1	33149943	33149943	+	Frame_Shift_Del	DEL	C	C	-			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:33149943delC	uc001bvt.2	-	3	1374	c.1274delG	c.(1273-1275)AGAfs	p.R425fs	SYNC_uc010ohl.1_Frame_Shift_Del_p.R425fs|RBBP4_uc001bvr.2_3'UTR|RBBP4_uc001bvs.2_3'UTR|RBBP4_uc010ohj.1_3'UTR|RBBP4_uc010ohk.1_3'UTR	NM_030786	NP_110413	Q9H7C4	SYNCI_HUMAN	syncoilin, intermediate filament 1 isoform 1	425	Coil 2.					intermediate filament|perinuclear region of cytoplasm	structural molecule activity			ovary(1)	1						CACCCCATTTCTTAACTGCCT	0.443		NaN											NaN	NaN	NaN	NaN	NaN	33	112	---	---							
MLL2	8085	broad.mit.edu	37	12	49445896	49445896	+	Frame_Shift_Del	DEL	C	C	-			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08			C	-	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:49445896delC	uc001rta.3	-	10	1570	c.1570delG	c.(1570-1572)GAAfs	p.E524fs		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	524	15 X 5 AA repeats of S/P-P-P-E/P-E/A.|Pro-rich.|6.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GGTGACTCTTCCGGTGGAGAC	0.597		NaN	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			NaN	NaN	NaN	NaN	NaN	17	55	---	---							
RBL2	5934	broad.mit.edu	37	16	53488655	53488655	+	Frame_Shift_Del	DEL	G	G	-			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr16:53488655delG	uc002ehi.3	+	8	1198	c.1080delG	c.(1078-1080)GAGfs	p.E360fs	RBL2_uc010vgv.1_Frame_Shift_Del_p.E286fs|RBL2_uc002ehj.2_Frame_Shift_Del_p.E70fs|RBL2_uc010vgw.1_Frame_Shift_Del_p.E144fs	NM_005611	NP_005602	Q08999	RBL2_HUMAN	retinoblastoma-like 2 (p130)	360					cell cycle|chromatin modification|regulation of cell cycle|regulation of lipid kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5						ATGCTGAGGAGGAAATTGGGA	0.428		NaN											NaN	NaN	NaN	NaN	NaN	29	31	---	---							
SMYD4	114826	broad.mit.edu	37	17	1704320	1704321	+	Splice_Site	INS	-	-	C			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:1704320_1704321insC	uc002ftm.3	-	5	538	c.370_splice	c.e5-1	p.T124_splice	SMYD4_uc002ftn.1_Splice_Site	NM_052928	NP_443160	Q8IYR2	SMYD4_HUMAN	SET and MYND domain containing 4								zinc ion binding			skin(3)|kidney(2)	5						AAGACACGTCTGAAAACAGAAA	0.381		NaN											NaN	NaN	NaN	NaN	NaN	36	67	---	---							
KRTAP4-1	85285	broad.mit.edu	37	17	39340475	39340477	+	Splice_Site	DEL	TGC	TGC	-	rs145519739		TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:39340475_39340477delTGC	uc002hwe.3	-	2	613	c.572_splice	c.e2+1			NM_033060	NP_149049	Q9BYQ7	KRA41_HUMAN	keratin associated protein 4-1							keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			GAGGTCTGAATGCTGCTGGGAAG	0.379		NaN											NaN	NaN	NaN	NaN	NaN	3	3	---	---							
NOP56	10528	broad.mit.edu	37	20	2635118	2635118	+	Frame_Shift_Del	DEL	G	G	-			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr20:2635118delG	uc002wgh.2	+	4	320	c.267delG	c.(265-267)AAGfs	p.K89fs	NOP56_uc010zpy.1_RNA|NOP56_uc002wgi.2_5'UTR|SNORA51_uc002wgk.1_5'Flank|NOP56_uc002wgm.1_5'Flank|SNORD86_uc010gaq.1_5'Flank|SNORD56_uc010gar.2_5'Flank|SNORD57_uc002wgo.1_5'Flank	NM_006392	NP_006383	O00567	NOP56_HUMAN	nucleolar protein 5A	89					rRNA processing	box C/D snoRNP complex|pre-snoRNP complex	protein binding|snoRNA binding			ovary(1)|pancreas(1)	2						CCAAAAAGAAGAAAGTACTCT	0.537		NaN											NaN	NaN	NaN	NaN	NaN	45	72	---	---							
HERC5	51191	broad.mit.edu	37	4	89415386	89415386	+	Frame_Shift_Del	DEL	T	T	-			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr4:89415386delT	uc003hrt.2	+	18	2501	c.2348delT	c.(2347-2349)GTTfs	p.V783fs	HERC5_uc011cdm.1_Frame_Shift_Del_p.V421fs	NM_016323	NP_057407	Q9UII4	HERC5_HUMAN	hect domain and RLD 5	783	HECT.				innate immune response|ISG15-protein conjugation|negative regulation of type I interferon production|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cyclin-dependent protein kinase activity|regulation of defense response to virus|response to virus	cytosol|perinuclear region of cytoplasm	ISG15 ligase activity|protein binding|ubiquitin-protein ligase activity			ovary(4)|lung(3)|skin(2)	9		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000209)		AATTGCAATGTTGCCAACCTT	0.368		NaN											NaN	NaN	NaN	NaN	NaN	12	37	---	---							
FOXQ1	94234	broad.mit.edu	37	6	1313255	1313256	+	Frame_Shift_Ins	INS	-	-	GC			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr6:1313255_1313256insGC	uc003mtl.3	+	1	581_582	c.316_317insGC	c.(316-318)GGCfs	p.G106fs		NM_033260	NP_150285	Q9C009	FOXQ1_HUMAN	forkhead box Q1	106					DNA fragmentation involved in apoptotic nuclear change|embryo development|hair follicle morphogenesis|pattern specification process|positive regulation of caspase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	caspase regulator activity|DNA bending activity|double-stranded DNA binding|estrogen receptor binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin conjugating enzyme binding				0	Ovarian(93;0.0733)	Breast(5;0.052)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.0954)|BRCA - Breast invasive adenocarcinoma(62;0.18)		cgcggggagcggcgagggtgCA	0.322		NaN											NaN	NaN	NaN	NaN	NaN	7	11	---	---							
HOXA3	3200	broad.mit.edu	37	7	27148001	27148005	+	Frame_Shift_Del	DEL	ACGGG	ACGGG	-			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr7:27148001_27148005delACGGG	uc011jzl.1	-	3	1061_1065	c.861_865delCCCGT	c.(859-867)GTCCCGTATfs	p.V287fs	HOXA3_uc011jzk.1_Frame_Shift_Del_p.V129fs|HOXA3_uc003syk.2_Frame_Shift_Del_p.V287fs	NM_030661	NP_109377	O43365	HXA3_HUMAN	homeobox A3 isoform a	287_289					angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)	2						TGGGGCTCATACGGGACGCTGTTGA	0.693		NaN											NaN	NaN	NaN	NaN	NaN	27	57	---	---							
SULF1	23213	broad.mit.edu	37	8	70536366	70536366	+	Frame_Shift_Del	DEL	G	G	-			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr8:70536366delG	uc010lza.1	+	15	2501	c.1784delG	c.(1783-1785)AGGfs	p.R595fs	SULF1_uc003xyd.2_Frame_Shift_Del_p.R595fs|SULF1_uc003xye.2_Frame_Shift_Del_p.R595fs|SULF1_uc003xyf.2_Frame_Shift_Del_p.R595fs|SULF1_uc003xyg.2_Frame_Shift_Del_p.R595fs|SULF1_uc003xyh.1_RNA	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	595					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			GGTGGCAACAGGGGCAGGATG	0.512		NaN											NaN	NaN	NaN	NaN	NaN	9	20	---	---