Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
C1orf86	199990	broad.mit.edu	37	1	2121153	2121153	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:2121153A>G	uc001aiy.2	-	4	564	c.538T>C	c.(538-540)TGG>CGG	p.W180R	C1orf86_uc001aiv.1_RNA|C1orf86_uc001aiw.1_RNA|C1orf86_uc001aix.1_Intron|uc001aiz.1_5'Flank	NM_182533	NP_872339	Q6NZ36	CA086_HUMAN	hypothetical protein LOC199990 isoform 2	180											0	all_cancers(77;0.000134)|all_epithelial(69;4.45e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;1.14e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.09e-37)|OV - Ovarian serous cystadenocarcinoma(86;1.5e-23)|GBM - Glioblastoma multiforme(42;1.61e-08)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00437)|STAD - Stomach adenocarcinoma(132;0.0134)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		GGCGCTCACCACGTCACGTCT	0.706		NaN											0	0	0	0.020292	0	12	40									
SYF2	25949	broad.mit.edu	37	1	25551554	25551554	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:25551554G>A	uc001bjt.1	-	6	560	c.505C>T	c.(505-507)CAT>TAT	p.H169Y	SYF2_uc001bju.1_Missense_Mutation_p.H127Y	NM_015484	NP_056299	O95926	SYF2_HUMAN	SYF2 homolog, RNA splicing factor isoform 1	169						catalytic step 2 spliceosome					0		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.5e-26)|Colorectal(126;2.54e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000455)|STAD - Stomach adenocarcinoma(196;0.000766)|KIRC - Kidney renal clear cell carcinoma(1967;0.00145)|GBM - Glioblastoma multiforme(114;0.00443)|READ - Rectum adenocarcinoma(331;0.0936)|Lung(427;0.201)		TGTGTTCCATGAAGAAGACTA	0.373		NaN											0	0	0	0.036044	0	33	79									
PIGV	55650	broad.mit.edu	37	1	27124128	27124128	+	Silent	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:27124128G>A	uc001bmz.2	+	4	1606	c.1275G>A	c.(1273-1275)GAG>GAA	p.E425E	PIGV_uc001bmy.2_Silent_p.E190E|PIGV_uc009vso.2_Missense_Mutation_p.A419T|PIGV_uc010ofg.1_Silent_p.E190E|PIGV_uc001bna.2_Silent_p.E425E	NM_017837	NP_060307	Q9NUD9	PIGV_HUMAN	phosphatidylinositol glycan class V	425	Lumenal (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	glycolipid mannosyltransferase activity			ovary(1)	1		all_cancers(24;3.93e-26)|all_epithelial(13;3.96e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.26e-54)|Epithelial(14;2.85e-53)|OV - Ovarian serous cystadenocarcinoma(117;1.91e-30)|Colorectal(126;1.31e-09)|COAD - Colon adenocarcinoma(152;3.45e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000504)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.0222)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.153)|LUSC - Lung squamous cell carcinoma(448;0.227)		AGGATCAAGAGCCGCTGTTGA	0.488		NaN											0	0	0	0.016522	0	23	60									
ZMYM4	9202	broad.mit.edu	37	1	35864515	35864515	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:35864515C>T	uc001byt.2	+	22	3384	c.3304C>T	c.(3304-3306)CCA>TCA	p.P1102S	ZMYM4_uc009vuu.2_Missense_Mutation_p.P1070S|ZMYM4_uc001byu.2_Missense_Mutation_p.P778S|ZMYM4_uc009vuv.2_Missense_Mutation_p.P841S	NM_005095	NP_005086	Q5VZL5	ZMYM4_HUMAN	zinc finger protein 262	1102					multicellular organismal development		DNA binding|zinc ion binding			large_intestine(2)|ovary(1)|kidney(1)|skin(1)	5		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AGTATCTACTCCACATAGCTG	0.398		NaN											0	0	0	0.008871	0	14	84									
LRRC41	10489	broad.mit.edu	37	1	46746098	46746098	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:46746098C>T	uc001cpn.2	-	6	1935	c.1891G>A	c.(1891-1893)GAT>AAT	p.D631N	LRRC41_uc010omb.1_Missense_Mutation_p.D631N	NM_006369	NP_006360	Q15345	LRC41_HUMAN	MUF1 protein	631	LRR 4.									ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(166;0.155)					AGCCCAAAATCCTGGGGAGAG	0.572		NaN											0	0	0	0.012319	0	19	103									
OSBPL9	114883	broad.mit.edu	37	1	52251500	52251500	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:52251500C>G	uc001cst.2	+	21	1869	c.1850C>G	c.(1849-1851)TCT>TGT	p.S617C	OSBPL9_uc001css.2_Missense_Mutation_p.S622C|OSBPL9_uc001csx.2_RNA|OSBPL9_uc009vza.2_Missense_Mutation_p.S618C|OSBPL9_uc001csu.2_Missense_Mutation_p.S627C|OSBPL9_uc001csv.2_Missense_Mutation_p.S452C|OSBPL9_uc001csw.2_Missense_Mutation_p.S604C|OSBPL9_uc001csy.2_Missense_Mutation_p.S439C|OSBPL9_uc001csz.2_Missense_Mutation_p.S439C|OSBPL9_uc001cta.2_Missense_Mutation_p.S507C|OSBPL9_uc001ctb.2_Missense_Mutation_p.S402C	NM_024586	NP_078862	Q96SU4	OSBL9_HUMAN	oxysterol binding protein-like 9 isoform e	617					lipid transport		lipid binding			central_nervous_system(1)	1						GACAAGAAGTCTTTTTGCTCA	0.383		NaN											0	0	0	0.037714	0	23	113									
ZCCHC11	23318	broad.mit.edu	37	1	52991393	52991393	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:52991393G>A	uc001ctx.2	-	2	794	c.560C>T	c.(559-561)TCC>TTC	p.S187F	ZCCHC11_uc001cty.2_Missense_Mutation_p.S187F|ZCCHC11_uc001ctz.2_Missense_Mutation_p.S187F|ZCCHC11_uc009vze.1_Missense_Mutation_p.S187F|ZCCHC11_uc009vzf.1_Intron|ZCCHC11_uc001cub.2_Missense_Mutation_p.S187F|ZCCHC11_uc001cuc.2_RNA|ZCCHC11_uc001cud.2_Missense_Mutation_p.S187F	NM_015269	NP_056084	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11 isoform	187					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)|skin(1)	3						AGAAGTAAAGGAGCTTGGAAT	0.413		NaN											0	0	0	0.012213	0	29	144									
DOCK7	85440	broad.mit.edu	37	1	62993831	62993831	+	Silent	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:62993831G>A	uc001daq.2	-	31	3961	c.3927C>T	c.(3925-3927)CTC>CTT	p.L1309L	DOCK7_uc001dan.2_Silent_p.L1170L|DOCK7_uc001dao.2_Silent_p.L1170L|DOCK7_uc001dap.2_Silent_p.L1278L|DOCK7_uc001dam.2_Silent_p.L489L|DOCK7_uc010oov.1_Intron	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	1309					activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						CCGTTGACGTGAGGAGGAAAC	0.413		NaN											0	0	0	0.013537	0	11	58									
DNAJB4	11080	broad.mit.edu	37	1	78479241	78479241	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:78479241C>A	uc001dij.2	+	2	877	c.718C>A	c.(718-720)CAT>AAT	p.H240N	DNAJB4_uc010orn.1_Missense_Mutation_p.H125N	NM_007034	NP_008965	Q9UDY4	DNJB4_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 4	240					protein folding|response to heat|response to unfolded protein	cytoplasm|plasma membrane	heat shock protein binding|unfolded protein binding				0						AGACAAAGATCATCCAAAATT	0.323		NaN											1	0	9.57634e-11	0.01892	1.06179e-10	20	92									
IFI44L	10964	broad.mit.edu	37	1	79102774	79102774	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:79102774C>G	uc010oro.1	+	6	1113	c.934C>G	c.(934-936)CTG>GTG	p.L312V	IFI44L_uc010orp.1_Missense_Mutation_p.L49V|IFI44L_uc010orq.1_Missense_Mutation_p.L49V	NM_006820	NP_006811	Q53G44	IF44L_HUMAN	interferon-induced protein 44-like	312						cytoplasm					0						CTCTCCATCTCTGAAGGACAG	0.368		NaN											0	0	0	0.030466	0	29	158									
CCBL2	56267	broad.mit.edu	37	1	89414843	89414843	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:89414843C>T	uc001dmp.2	-	11	1449	c.1072G>A	c.(1072-1074)GAA>AAA	p.E358K	CCBL2_uc001dmq.2_Missense_Mutation_p.E324K|CCBL2_uc001dmr.2_Missense_Mutation_p.E194K	NM_001008661	NP_001008661	Q6YP21	KAT3_HUMAN	kynurenine aminotransferase III isoform 1	358					biosynthetic process|kynurenine metabolic process|tryptophan catabolic process		cysteine-S-conjugate beta-lyase activity|kynurenine-glyoxylate transaminase activity|kynurenine-oxoglutarate transaminase activity|pyridoxal phosphate binding			ovary(1)	1		Lung NSC(277;0.123)		all cancers(265;0.0117)|Epithelial(280;0.0341)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	CCAACACTTTCAAGTAAACGT	0.373		NaN											0	0	0	0.012319	0	18	73									
ABCD3	5825	broad.mit.edu	37	1	94933515	94933515	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:94933515G>C	uc001dqn.3	+	4	389	c.287G>C	c.(286-288)CGA>CCA	p.R96P	ABCD3_uc001dqm.3_Missense_Mutation_p.R96P|ABCD3_uc010oto.1_Missense_Mutation_p.R120P|ABCD3_uc010otp.1_Missense_Mutation_p.R23P|ABCD3_uc009wdr.2_Missense_Mutation_p.R96P	NM_002858	NP_002849	P28288	ABCD3_HUMAN	ATP-binding cassette, sub-family D, member 3	96	ABC transmembrane type-1.|Targeting to peroxisomes.|Helical; (Potential).|Interaction with PEX19.				peroxisomal long-chain fatty acid import|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(1)	1		all_lung(203;0.000434)|Lung NSC(277;0.0019)		all cancers(265;0.0261)|Epithelial(280;0.165)		CTGGTGTCTCGAACATATTGT	0.313		NaN											0	0	0	0.008291	0	7	55									
COL11A1	1301	broad.mit.edu	37	1	103483426	103483426	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:103483426G>A	uc001dul.2	-	11	1681	c.1363C>T	c.(1363-1365)CCT>TCT	p.P455S	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Missense_Mutation_p.P467S|COL11A1_uc001dun.2_Missense_Mutation_p.P416S|COL11A1_uc009weh.2_Missense_Mutation_p.P339S	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	455	Triple-helical region (interrupted).				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		AGACCTGGAGGACCCATAATA	0.418		NaN											0	0	0	0.01441	0	44	94									
NTNG1	22854	broad.mit.edu	37	1	108023313	108023313	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:108023313G>T	uc001dvh.3	+	8	2189	c.1471G>T	c.(1471-1473)GCA>TCA	p.A491S	NTNG1_uc001dvf.3_Missense_Mutation_p.A432S|NTNG1_uc010out.1_Missense_Mutation_p.A457S|NTNG1_uc001dvc.3_Missense_Mutation_p.A390S|NTNG1_uc001dvi.2_Silent_p.P58P|NTNG1_uc001dve.2_RNA|NTNG1_uc009wek.2_RNA|NTNG1_uc001dvg.2_RNA|NTNG1_uc009wem.2_Missense_Mutation_p.R53L	NM_001113226	NP_001106697	Q9Y2I2	NTNG1_HUMAN	netrin G1 isoform 1	491					axonogenesis	anchored to plasma membrane	protein binding			large_intestine(2)|ovary(2)|skin(2)	6		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		GTGCCCGGCCGCATACACGGG	0.687		NaN											1	0	1.58986e-06	0.008291	1.67186e-06	7	50									
SYT6	148281	broad.mit.edu	37	1	114640500	114640500	+	Splice_Site	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:114640500C>G	uc001eev.2	-	6	1360	c.1110_splice	c.e6-1	p.R370_splice	SYT6_uc001eeu.2_Splice_Site_p.R15_splice	NM_205848	NP_995320	Q5T7P8	SYT6_HUMAN	synaptotagmin VI						acrosomal vesicle exocytosis	cell junction|cytosol|integral to membrane|perinuclear endoplasmic reticulum|peripheral to membrane of membrane fraction|synaptic vesicle membrane	clathrin binding|metal ion binding|protein homodimerization activity|syntaxin binding|transporter activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Lung SC(450;0.184)	all_cancers(81;4.41e-08)|all_epithelial(167;5.18e-08)|all_lung(203;1.58e-05)|Lung NSC(69;2.82e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTGGCCCACTCTGAGGGAGAA	0.577		NaN											0	0	0	0.010504	0	15	77									
WDR3	10885	broad.mit.edu	37	1	118496158	118496158	+	Silent	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:118496158G>A	uc010oxe.1	+	21	2328	c.2262G>A	c.(2260-2262)GTG>GTA	p.V754V	WDR3_uc001ehi.2_Intron	NM_006784	NP_006775	Q9UNX4	WDR3_HUMAN	WD repeat-containing protein 3	754						nuclear membrane|nucleolus				upper_aerodigestive_tract(1)	1	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)		TTGAAACAGTGAAAGCAGTAA	0.333		NaN											0	0	0	0.010504	0	17	40									
WDR3	10885	broad.mit.edu	37	1	118496687	118496687	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:118496687G>A	uc010oxe.1	+	22	2392	c.2326G>A	c.(2326-2328)GAA>AAA	p.E776K	WDR3_uc001ehi.2_Intron|SPAG17_uc001ehk.2_Intron	NM_006784	NP_006775	Q9UNX4	WDR3_HUMAN	WD repeat-containing protein 3	776						nuclear membrane|nucleolus				upper_aerodigestive_tract(1)	1	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)		AAAAATGAAGGAACACAAAGC	0.398		NaN											0	0	0	0.017118	0	25	56									
RUSC1	23623	broad.mit.edu	37	1	155291967	155291967	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:155291967C>T	uc001fkj.2	+	2	632	c.403C>T	c.(403-405)CAG>TAG	p.Q135*	RAG1AP1_uc010pey.1_Intron|C1orf104_uc001fkh.1_5'Flank|C1orf104_uc001fki.2_Intron|RUSC1_uc001fkk.2_Nonsense_Mutation_p.Q135*|RUSC1_uc009wqn.1_RNA|RUSC1_uc009wqo.1_5'Flank|RUSC1_uc001fkl.2_5'Flank|RUSC1_uc001fkp.2_5'Flank|RUSC1_uc001fkq.2_5'Flank|RUSC1_uc010pgb.1_5'Flank|RUSC1_uc009wqp.1_5'Flank|RUSC1_uc001fkn.2_5'Flank|RUSC1_uc001fko.2_5'Flank|RUSC1_uc001fkr.2_5'Flank	NM_001105203	NP_001098673	Q9BVN2	RUSC1_HUMAN	RUN and SH3 domain containing 1 isoform a	135						cytoplasm|nucleolus	SH3/SH2 adaptor activity			ovary(2)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;1.55e-10)|all cancers(21;4.15e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)			TGCCCACCCTCAGCCCAGTAT	0.622		NaN											0	0	0	0.016723	0	11	70									
GON4L	54856	broad.mit.edu	37	1	155791331	155791331	+	Silent	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:155791331G>A	uc001flz.2	-	5	994	c.897C>T	c.(895-897)ATC>ATT	p.I299I	GON4L_uc001fly.1_Silent_p.I299I|GON4L_uc009wrh.1_Silent_p.I299I|GON4L_uc001fma.1_Silent_p.I299I|GON4L_uc001fmc.2_Silent_p.I299I|GON4L_uc001fmd.3_Silent_p.I299I|GON4L_uc009wri.2_5'UTR|GON4L_uc001fme.2_Silent_p.I127I|GON4L_uc001fmf.2_5'UTR	NM_001037533	NP_001032622	Q3T8J9	GON4L_HUMAN	gon-4-like isoform a	299					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(3)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					GTTCATTTGTGATTACTTCCT	0.393		NaN											0	0	0	0.028581	0	16	72									
TMCO1	54499	broad.mit.edu	37	1	165737466	165737466	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:165737466C>G	uc001gdj.3	-	2	260	c.111G>C	c.(109-111)AAG>AAC	p.K37N	TMCO1_uc001gdl.3_5'UTR|TMCO1_uc001gdm.3_5'UTR|TMCO1_uc001gdk.3_Missense_Mutation_p.K25N|TMCO1_uc001gdn.3_RNA|uc001gdo.2_5'Flank	NM_019026	NP_061899	Q9UM00	TMCO1_HUMAN	transmembrane and coiled-coil domains 1	37	Potential.					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				central_nervous_system(1)	1	all_hematologic(923;0.048)|Acute lymphoblastic leukemia(8;0.155)					CCTTCAGTCTCTTGTACTTGT	0.363		NaN											0	0	0	0.00308	0	6	41									
F5	2153	broad.mit.edu	37	1	169551671	169551671	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:169551671G>A	uc001ggg.1	-	2	393	c.248C>T	c.(247-249)TCA>TTA	p.S83L	F5_uc010plr.1_Intron	NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	83	F5/8 type A 1.|Plastocyanin-like 1.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	AGGCTTACCTGAAATGGTAGA	0.264		NaN											0	0	0	0.00308	0	8	16									
PAPPA2	60676	broad.mit.edu	37	1	176564245	176564245	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:176564245C>T	uc001gkz.2	+	3	2669	c.1505C>T	c.(1504-1506)ACA>ATA	p.T502I	PAPPA2_uc001gky.1_Missense_Mutation_p.T502I|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	502	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						TGTGGGCAAACAGTCTGTGAC	0.522		NaN											0	0	0	0.014758	0	4	39									
UCHL5	51377	broad.mit.edu	37	1	193020927	193020927	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:193020927C>A	uc001gsm.2	-	2	228	c.97G>T	c.(97-99)GAA>TAA	p.E33*	UCHL5_uc001gsn.2_RNA|UCHL5_uc001gso.2_Nonsense_Mutation_p.E33*|UCHL5_uc010pov.1_RNA|UCHL5_uc001gsp.2_Nonsense_Mutation_p.E33*|UCHL5_uc001gsq.2_Nonsense_Mutation_p.E33*|UCHL5_uc010pow.1_5'UTR|UCHL5_uc010pox.1_5'UTR	NM_015984	NP_057068	Q9Y5K5	UCHL5_HUMAN	ubiquitin carboxyl-terminal hydrolase L5	33					DNA recombination|DNA repair|protein deubiquitination|regulation of proteasomal protein catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytosol|Ino80 complex|proteasome complex	endopeptidase inhibitor activity|omega peptidase activity|proteasome binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|ovary(1)	3						CATATTTCTTCTACTTGGGCT	0.249		NaN											1	0	3.90053e-15	0.012213	4.36431e-15	23	101									
CRB1	23418	broad.mit.edu	37	1	197297651	197297651	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:197297651C>T	uc001gtz.2	+	2	305	c.170C>T	c.(169-171)TCA>TTA	p.S57L	CRB1_uc010poz.1_5'UTR|CRB1_uc001gty.1_Missense_Mutation_p.S57L|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.S57L|CRB1_uc010ppb.1_Missense_Mutation_p.S57L	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	57	Extracellular (Potential).|EGF-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						TGTTCTTGTTCAGACACAGCC	0.403		NaN											0	0	0	0.004482	0	9	44									
ZNF281	23528	broad.mit.edu	37	1	200377122	200377122	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:200377122C>T	uc001gve.2	-	2	1819	c.1712G>A	c.(1711-1713)GGT>GAT	p.G571D	ZNF281_uc001gvf.1_Missense_Mutation_p.G571D|ZNF281_uc001gvg.1_Missense_Mutation_p.G535D	NM_012482	NP_036614	Q9Y2X9	ZN281_HUMAN	zinc finger protein 281	571					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|breast(1)	2						AACACTGACACCTGCAGACTG	0.413		NaN											0	0	0	0.02938	0	5	18									
MYOG	4656	broad.mit.edu	37	1	203054922	203054922	+	Silent	SNP	C	C	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:203054922C>A	uc001gzd.2	-	1	456	c.168G>T	c.(166-168)GGG>GGT	p.G56G		NM_002479	NP_002470	P15173	MYOG_HUMAN	myogenin	56					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter	transcription factor complex	E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity			skin(2)	2						GCTCGGGGGTCCCCAGCCCCT	0.697		NaN											1	0	1.28384e-07	0.012319	1.37769e-07	17	48									
OPTC	26254	broad.mit.edu	37	1	203465269	203465269	+	Silent	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:203465269C>T	uc001gzu.1	+	2	252	c.136C>T	c.(136-138)CTG>TTG	p.L46L		NM_014359	NP_055174	Q9UBM4	OPT_HUMAN	opticin precursor	46						proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding				0			BRCA - Breast invasive adenocarcinoma(75;0.109)			AGTTCTGCCTCTGCGGAATGA	0.542		NaN											0	0	0	0.007413	0	16	51									
NFASC	23114	broad.mit.edu	37	1	204985457	204985457	+	Silent	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:204985457G>A	uc001hbj.2	+	30	3841	c.3513G>A	c.(3511-3513)CTG>CTA	p.L1171L	NFASC_uc010pra.1_Silent_p.L1105L|NFASC_uc001hbi.2_Silent_p.L1100L|NFASC_uc010prb.1_Silent_p.L1120L|NFASC_uc010prc.1_Silent_p.L671L|NFASC_uc001hbl.1_Silent_p.L247L|NFASC_uc001hbm.1_Silent_p.L194L|NFASC_uc009xbh.1_Missense_Mutation_p.C26Y|NFASC_uc001hbo.1_Missense_Mutation_p.C47Y	NM_001005388	NP_001005388	O94856	NFASC_HUMAN	neurofascin isoform 1 precursor	1278	Cytoplasmic (Potential).				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			ACAAGCCCCTGCAGGGCAGTC	0.592		NaN											0	0	0	0.01441	0	54	156									
FAIM3	9214	broad.mit.edu	37	1	207087417	207087417	+	Silent	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:207087417G>A	uc001hey.2	-	2	239	c.60C>T	c.(58-60)CTC>CTT	p.L20L	FAIM3_uc010prz.1_Intron|FAIM3_uc010psa.1_5'UTR|FAIM3_uc010psb.1_Silent_p.L20L	NM_005449	NP_005440	O60667	FAIM3_HUMAN	Fas apoptotic inhibitory molecule 3 isoform a	20	Extracellular (Potential).				anti-apoptosis|cellular defense response	integral to membrane				central_nervous_system(1)	1	Breast(84;0.201)					TTACTTCTGGGAGGATCCTCA	0.418		NaN											0	0	0	0.008871	0	19	86									
CR2	1380	broad.mit.edu	37	1	207640030	207640030	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:207640030G>T	uc001hfw.2	+	2	312	c.218G>T	c.(217-219)GGA>GTA	p.G73V	CR2_uc001hfv.2_Missense_Mutation_p.G73V|CR2_uc009xch.2_Missense_Mutation_p.G73V	NM_001877	NP_001868	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus)	73	Sushi 1.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8						AAAGTGGATGGAACCTGGGAT	0.408		NaN											1	0	3.27435e-08	0.020292	3.5448e-08	14	60									
MARK1	4139	broad.mit.edu	37	1	220792050	220792050	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:220792050C>A	uc001hmn.3	+	9	1459	c.862C>A	c.(862-864)CTG>ATG	p.L288M	MARK1_uc009xdw.2_Missense_Mutation_p.L288M|MARK1_uc010pun.1_Missense_Mutation_p.L288M|MARK1_uc001hmm.3_Missense_Mutation_p.L266M	NM_018650	NP_061120	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	288	Protein kinase.				intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(4)|central_nervous_system(2)|skin(2)|stomach(1)|lung(1)	10				GBM - Glioblastoma multiforme(131;0.0407)		TGAAAATCTTCTGAAGAAATT	0.328		NaN											1	0	0.00010058	0.013537	0.000103688	10	52									
TTC13	79573	broad.mit.edu	37	1	231076227	231076227	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:231076227G>A	uc001huf.3	-	7	779	c.748C>T	c.(748-750)CGG>TGG	p.R250W	TTC13_uc009xfi.2_Missense_Mutation_p.R197W|TTC13_uc009xfj.2_RNA|TTC13_uc001hug.3_Missense_Mutation_p.R197W|TTC13_uc009xfk.1_Missense_Mutation_p.R140W	NM_024525	NP_078801	Q8NBP0	TTC13_HUMAN	tetratricopeptide repeat domain 13 isoform a	250	TPR 3.						binding			ovary(1)|skin(1)	2	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)		COAD - Colon adenocarcinoma(196;0.243)		CTGTACAGCCGTGCTGAGGGC	0.423		NaN											0	0	0	0.020292	0	12	52									
KCNK1	3775	broad.mit.edu	37	1	233807173	233807173	+	Missense_Mutation	SNP	C	C	T	rs149408317		TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:233807173C>T	uc010pxo.1	+	3	1076	c.908C>T	c.(907-909)TCG>TTG	p.S303L	KCNK1_uc001hvw.2_RNA|KCNK1_uc001hvx.2_RNA	NM_002245	NP_002236	O00180	KCNK1_HUMAN	potassium channel, subfamily K, member 1	303	Cytoplasmic (Potential).					voltage-gated potassium channel complex	inward rectifier potassium channel activity			central_nervous_system(1)	1		all_cancers(173;0.00217)|all_epithelial(177;0.121)|Prostate(94;0.122)|Acute lymphoblastic leukemia(190;0.175)			Ibutilide(DB00308)|Quinidine(DB00908)	TCCTTCTCCTCGATCACAGAC	0.493		NaN											0	0	0	0.024245	0	15	31									
CEP170	9859	broad.mit.edu	37	1	243349256	243349256	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:243349256G>A	uc001hzs.2	-	10	1799	c.1391C>T	c.(1390-1392)TCA>TTA	p.S464L	CEP170_uc001hzt.2_Intron|CEP170_uc001hzu.2_Intron	NM_014812	NP_055627	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa isoform alpha	464						centriole|microtubule|spindle				ovary(1)|haematopoietic_and_lymphoid_tissue(1)	2	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			AAGACTCCCTGAACTTCTTAA	0.418		NaN											0	0	0	0.009096	0	4	43									
KIF26B	55083	broad.mit.edu	37	1	245582962	245582962	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:245582962G>A	uc001ibf.1	+	4	1521	c.1081G>A	c.(1081-1083)GCC>ACC	p.A361T	KIF26B_uc010pyq.1_Missense_Mutation_p.A361T	NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	361					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			CAAGCCTTCCGCCTGCAGTGT	0.572		NaN											0	0	0	0.007413	0	15	56									
KIF26B	55083	broad.mit.edu	37	1	245865906	245865906	+	Nonstop_Mutation	SNP	T	T	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:245865906T>C	uc001ibf.1	+	15	6765	c.6325T>C	c.(6325-6327)TAG>CAG	p.*2109Q		NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	2109					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			CAGGCGCCGGTAGATGAGCCA	0.597		NaN											0	0	0	0.037714	0	19	55									
OR2W3	343171	broad.mit.edu	37	1	248059565	248059565	+	Nonsense_Mutation	SNP	T	T	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:248059565T>G	uc001idp.1	+	3	946	c.677T>G	c.(676-678)TTA>TGA	p.L226*	OR2W3_uc010pzb.1_Nonsense_Mutation_p.L226*	NM_001001957	NP_001001957	Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W,	226	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|pancreas(1)	3	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			AGGGCTGTGTTACAAATTCGG	0.532		NaN											0	0	0	0.011902	0	35	108									
ADARB2	105	broad.mit.edu	37	10	1405318	1405318	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr10:1405318G>A	uc009xhq.2	-	3	1356	c.982C>T	c.(982-984)CGG>TGG	p.R328W		NM_018702	NP_061172	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2	328	DRBM 2.				mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)		GCCTGACCCCGGGCCAGCTTC	0.726		NaN											0	0	0	0.00308	0	5	9									
SVIL	6840	broad.mit.edu	37	10	29840096	29840096	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr10:29840096G>A	uc001iut.1	-	6	1010	c.257C>T	c.(256-258)TCA>TTA	p.S86L	SVIL_uc001iuu.1_Missense_Mutation_p.S86L|SVIL_uc009xld.1_Missense_Mutation_p.S86L	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	86	Interaction with MYLK (By similarity).				cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				ACCATAGGGTGAGTCACCGTG	0.493		NaN											0	0	0	0.007413	0	16	95									
SVIL	6840	broad.mit.edu	37	10	29840154	29840154	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr10:29840154G>T	uc001iut.1	-	6	952	c.199C>A	c.(199-201)CTA>ATA	p.L67I	SVIL_uc001iuu.1_Missense_Mutation_p.L67I|SVIL_uc009xld.1_Missense_Mutation_p.L67I	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	67	Interaction with MYLK (By similarity).				cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				TGCTTTTCTAGAGAAGAATCA	0.463		NaN											1	0	4.7546e-09	0.028581	5.20878e-09	12	47									
LRRTM3	347731	broad.mit.edu	37	10	68687354	68687354	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr10:68687354G>C	uc001jmz.1	+	2	1230	c.680G>C	c.(679-681)AGG>ACG	p.R227T	CTNNA3_uc009xpn.1_Intron|CTNNA3_uc001jmw.2_Intron|CTNNA3_uc001jmx.3_Intron|CTNNA3_uc009xpo.1_Intron|LRRTM3_uc001jmy.2_Missense_Mutation_p.R227T	NM_178011	NP_821079	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	227	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						CTTTTTCCAAGGTTGGTCAGC	0.453		NaN											0	0	0	0.024334	0	20	107									
TSPAN15	23555	broad.mit.edu	37	10	71265936	71265936	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr10:71265936C>G	uc001jpo.1	+	7	800	c.675C>G	c.(673-675)ATC>ATG	p.I225M		NM_012339	NP_036471	O95858	TSN15_HUMAN	transmembrane 4 superfamily member 15	225	Extracellular (Potential).					integral to plasma membrane|membrane fraction					0						CCGTGATCATCTGGTTCATGG	0.597		NaN											0	0	0	0.01441	0	102	76									
COL13A1	1305	broad.mit.edu	37	10	71562459	71562459	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr10:71562459C>T	uc001jpr.1	+	1	816	c.280C>T	c.(280-282)CAA>TAA	p.Q94*	COL13A1_uc001jqj.1_Nonsense_Mutation_p.Q94*|COL13A1_uc001jps.1_Nonsense_Mutation_p.Q94*|COL13A1_uc001jpt.1_Nonsense_Mutation_p.Q94*|COL13A1_uc001jpu.1_Nonsense_Mutation_p.Q94*|COL13A1_uc001jpv.1_Nonsense_Mutation_p.Q94*|COL13A1_uc001jpx.1_Nonsense_Mutation_p.Q94*|COL13A1_uc001jpw.1_Nonsense_Mutation_p.Q94*|COL13A1_uc001jpy.1_Nonsense_Mutation_p.Q94*|COL13A1_uc001jpz.1_Nonsense_Mutation_p.Q94*|COL13A1_uc001jqa.1_Nonsense_Mutation_p.Q94*|COL13A1_uc001jqc.1_Nonsense_Mutation_p.Q94*|COL13A1_uc001jqb.1_Nonsense_Mutation_p.Q94*|COL13A1_uc001jql.2_Nonsense_Mutation_p.Q94*|COL13A1_uc001jqd.1_Nonsense_Mutation_p.Q94*|COL13A1_uc001jqe.1_Nonsense_Mutation_p.Q94*|COL13A1_uc001jqf.1_Nonsense_Mutation_p.Q94*|COL13A1_uc001jqg.1_Nonsense_Mutation_p.Q94*|COL13A1_uc001jqh.1_Nonsense_Mutation_p.Q94*|COL13A1_uc001jqi.1_Nonsense_Mutation_p.Q94*	NM_005203	NP_005194	Q5TAT6	CODA1_HUMAN	alpha 1 type XIII collagen isoform 1	94	Extracellular (Potential).|Nonhelical region 1 (NC1).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|endochondral ossification|morphogenesis of a branching structure	collagen type XIII|integral to membrane	extracellular matrix structural constituent|heparin binding|protein binding			ovary(1)	1					Atorvastatin(DB01076)|Simvastatin(DB00641)	ACGAGTCAATCAACTGCTGGA	0.662		NaN											0	0	0	0.015359	0	32	404									
KCNMA1	3778	broad.mit.edu	37	10	78729810	78729810	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr10:78729810G>A	uc001jxn.2	-	20	2459	c.2282C>T	c.(2281-2283)CCG>CTG	p.P761L	KCNMA1_uc001jxj.2_Missense_Mutation_p.P707L|KCNMA1_uc001jxk.1_Missense_Mutation_p.P379L|KCNMA1_uc009xrt.1_Missense_Mutation_p.P552L|KCNMA1_uc001jxl.1_Missense_Mutation_p.P386L|KCNMA1_uc001jxo.2_Missense_Mutation_p.P703L|KCNMA1_uc001jxm.2_Missense_Mutation_p.P703L|KCNMA1_uc001jxq.2_Missense_Mutation_p.P706L	NM_001161352	NP_001154824	Q12791	KCMA1_HUMAN	large conductance calcium-activated potassium	761	Cytoplasmic (Potential).				cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	TAGTGTTGACGGCTGCTCATC	0.483		NaN											0	0	0	0.014758	0	4	67									
BTAF1	9044	broad.mit.edu	37	10	93749199	93749199	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr10:93749199C>A	uc001khr.2	+	20	2814	c.2716C>A	c.(2716-2718)CAG>AAG	p.Q906K	BTAF1_uc001khs.1_Missense_Mutation_p.Q576K|BTAF1_uc001kht.1_Missense_Mutation_p.Q344K	NM_003972	NP_003963	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription	906	HEAT 6.				negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)				TAAACTCCTTCAGCAGTGCAC	0.378		NaN											1	0	1.58986e-06	0.008291	1.67186e-06	9	41									
C10orf76	79591	broad.mit.edu	37	10	103783474	103783474	+	Silent	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr10:103783474G>A	uc009xwy.1	-	7	642	c.540C>T	c.(538-540)CTC>CTT	p.L180L		NM_024541	NP_078817	Q5T2E6	CJ076_HUMAN	hypothetical protein LOC79591	180						integral to membrane					0		Colorectal(252;0.123)		Epithelial(162;2.41e-08)|all cancers(201;6.41e-07)		TTACATACTCGAGAATAGTGT	0.383		NaN											0	0	0	0.012213	0	26	149									
SORCS3	22986	broad.mit.edu	37	10	106737176	106737176	+	Silent	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr10:106737176C>T	uc001kyi.1	+	4	1106	c.879C>T	c.(877-879)CTC>CTT	p.L293L		NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	293	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		AGTATCGGCTCACCTTCTATA	0.443		NaN											0	0	0	0.007413	0	17	42									
NRIP3	56675	broad.mit.edu	37	11	9009806	9009807	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:9009806_9009807CC>AA	uc001mhg.2	-	2	311_312	c.197_198GG>TT	c.(196-198)AGG>ATT	p.R66I	NRIP3_uc010rbu.1_Missense_Mutation_p.R66I	NM_020645	NP_065696	Q9NQ35	NRIP3_HUMAN	nuclear receptor interacting protein 3	66					proteolysis		aspartic-type endopeptidase activity				0				Epithelial(150;4.77e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0241)		CCATGAGGCGCCTCTGCAGAAT	0.51		NaN											0	0	0	0.004672	0	17	56									
GTF2H1	2965	broad.mit.edu	37	11	18362845	18362845	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:18362845G>C	uc001moi.2	+	7	1339	c.645G>C	c.(643-645)ATG>ATC	p.M215I	GTF2H1_uc001moh.2_Missense_Mutation_p.M215I|GTF2H1_uc009yhm.2_Missense_Mutation_p.M99I	NM_001142307	NP_001135779	P32780	TF2H1_HUMAN	general transcription factor IIH, polypeptide 1,	215	BSD 2.				mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	protein binding				0						CCCACAACATGACAGAGAAGG	0.358		NaN						NER					0	0	0	0.01892	0	22	59									
NAV2	89797	broad.mit.edu	37	11	20089894	20089894	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:20089894G>A	uc010rdm.1	+	24	5462	c.5101G>A	c.(5101-5103)GAT>AAT	p.D1701N	NAV2_uc001mpp.2_Missense_Mutation_p.D1581N|NAV2_uc001mpr.3_Missense_Mutation_p.D1645N|NAV2_uc001mpt.2_Missense_Mutation_p.D694N|NAV2_uc009yhx.2_Missense_Mutation_p.D709N|NAV2_uc009yhy.1_Missense_Mutation_p.D607N|NAV2_uc009yhz.2_Missense_Mutation_p.D290N|NAV2_uc001mpu.2_Missense_Mutation_p.D83N	NM_145117	NP_660093	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 2	1701	Potential.					nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						GCGGGAACTGGATGCCTCCCA	0.502		NaN											0	0	0	0.01441	0	63	127									
EXT2	2132	broad.mit.edu	37	11	44097105	44097105	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:44097105C>G	uc010rfo.1	+	1	30	c.17C>G	c.(16-18)TCT>TGT	p.S6C	ACCS_uc010rfm.1_Silent_p.L100L|ACCS_uc009yks.1_Silent_p.L173L|ACCS_uc010rfn.1_Missense_Mutation_p.L150V|ACCS_uc001mxx.2_Silent_p.L173L	NM_207122	NP_997005	Q93063	EXT2_HUMAN	exostosin 2 isoform 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction	Golgi membrane|integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity			lung(2)|breast(2)|skin(1)	5						GTGCCTCGCTCTTCTCTGCTC	0.602		NaN	Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses				0	0	0	0.024245	0	12	74									
CKAP5	9793	broad.mit.edu	37	11	46783565	46783565	+	Silent	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:46783565G>A	uc001ndi.1	-	32	4316	c.4206C>T	c.(4204-4206)TTC>TTT	p.F1402F	CKAP5_uc009ylg.1_Silent_p.F1288F|CKAP5_uc001ndj.1_Silent_p.F1402F|CKAP5_uc001ndh.1_Silent_p.F331F	NM_001008938	NP_001008938	Q14008	CKAP5_HUMAN	colonic and hepatic tumor over-expressed protein	1402					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2						CAATCAGTTTGAACACCTGAT	0.443		NaN											0	0	0	0.034045	0	26	100									
OR4C13	283092	broad.mit.edu	37	11	49974700	49974700	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:49974700C>G	uc010rhz.1	+	1	726	c.726C>G	c.(724-726)ATC>ATG	p.I242M		NM_001001955	NP_001001955	Q8NGP0	OR4CD_HUMAN	olfactory receptor, family 4, subfamily C,	242	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(1)	4						TCTCCCACATCACAGTTGTCA	0.463		NaN											0	0	0	0.01892	0	21	122									
MARK2	2011	broad.mit.edu	37	11	63668461	63668461	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:63668461G>T	uc001nxw.2	+	11	1600	c.1021G>T	c.(1021-1023)GAG>TAG	p.E341*	MARK2_uc001nxx.2_Nonsense_Mutation_p.E341*|MARK2_uc001nxy.2_Nonsense_Mutation_p.E341*|MARK2_uc001nxv.3_Nonsense_Mutation_p.E341*|MARK2_uc001nxz.3_Nonsense_Mutation_p.E308*|MARK2_uc009yoy.2_Nonsense_Mutation_p.E308*	NM_001039469	NP_001034558	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	341	UBA.				cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3						TACACGGGAAGAGATCCAGGA	0.577		NaN											1	0	1.08611e-07	0.010729	1.16892e-07	10	96									
SUV420H1	51111	broad.mit.edu	37	11	67957497	67957497	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:67957497C>G	uc001onm.1	-	2	303	c.47G>C	c.(46-48)AGA>ACA	p.R16T	SUV420H1_uc009yse.1_5'UTR|SUV420H1_uc001onn.1_5'UTR|SUV420H1_uc009ysf.2_5'UTR|SUV420H1_uc001ono.1_Missense_Mutation_p.R16T|SUV420H1_uc001onp.2_Missense_Mutation_p.R16T|SUV420H1_uc010rqa.1_Missense_Mutation_p.R16T|SUV420H1_uc001onq.2_Missense_Mutation_p.R16T	NM_017635	NP_060105	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 isoform	16					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(2)|kidney(1)	3						GCCTCCATTTCTCCTGCCATT	0.478		NaN											0	0	0	0.01441	0	58	292									
ARAP1	116985	broad.mit.edu	37	11	72418281	72418281	+	Silent	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:72418281C>T	uc001osu.2	-	12	1851	c.1662G>A	c.(1660-1662)GGG>GGA	p.G554G	ARAP1_uc001osv.2_Silent_p.G554G|ARAP1_uc001osr.2_Silent_p.G314G|ARAP1_uc001oss.2_Silent_p.G309G|ARAP1_uc009yth.2_Silent_p.G309G|ARAP1_uc010rre.1_Silent_p.G309G	NM_001040118	NP_001035207	Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	554	C4-type.|Arf-GAP.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			skin(1)	1						GCTGAGGAGCCCCGCAGTCAG	0.647		NaN											0	0	0	0.00308	0	7	10									
THRSP	7069	broad.mit.edu	37	11	77775045	77775045	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:77775045G>A	uc001oyx.2	+	1	139	c.118G>A	c.(118-120)GTG>ATG	p.V40M		NM_003251	NP_003242	Q92748	THRSP_HUMAN	thyroid hormone-responsive protein	40					lipid biosynthetic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus				breast(1)	1	all_cancers(14;2.23e-19)|all_epithelial(13;7.49e-22)|Breast(9;6.38e-17)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;2.15e-25)			TCTGCGGGACGTGCAGCTGAG	0.617		NaN											0	0	0	0.014323	0	21	110									
PRCP	5547	broad.mit.edu	37	11	82560964	82560964	+	Nonsense_Mutation	SNP	G	G	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:82560964G>C	uc001ozs.2	-	5	856	c.743C>G	c.(742-744)TCA>TGA	p.S248*	PRCP_uc001ozr.2_Nonsense_Mutation_p.S269*	NM_005040	NP_005031	P42785	PCP_HUMAN	prolylcarboxypeptidase isoform 1 preproprotein	248	SKS domain.				blood coagulation, intrinsic pathway|proteolysis	lysosome|plasma membrane	protein binding|serine-type carboxypeptidase activity			skin(1)	1						ACCAGTATTTGAGAGTCGATT	0.338		NaN											0	0	0	0.016723	0	9	99									
CCDC81	60494	broad.mit.edu	37	11	86133623	86133623	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:86133623G>A	uc001pbx.1	+	15	2253	c.1825G>A	c.(1825-1827)GAC>AAC	p.D609N	CCDC81_uc001pbw.1_Missense_Mutation_p.D519N|CCDC81_uc010rtq.1_Missense_Mutation_p.D392N|CCDC81_uc001pby.1_Missense_Mutation_p.D344N	NM_001156474	NP_001149946	Q6ZN84	CCD81_HUMAN	coiled-coil domain containing 81 isoform 1	609										skin(1)	1		Acute lymphoblastic leukemia(157;5.51e-06)|all_hematologic(158;0.00535)				CAGGGCTTCAGACAAGCTGTT	0.562		NaN											0	0	0	0.013726	0	28	76									
FAT3	120114	broad.mit.edu	37	11	92616453	92616453	+	Silent	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:92616453G>A	uc001pdj.3	+	23	12848	c.12831G>A	c.(12829-12831)CGG>CGA	p.R4277R	FAT3_uc001pdi.3_Silent_p.R717R	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	4277	Cytoplasmic (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TGACAGCCCGGCGGGGCGTGG	0.662		NaN								TCGA Ovarian(4;0.039)			0	0	0	0.012213	0	28	96									
KIAA1377	57562	broad.mit.edu	37	11	101857622	101857622	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:101857622G>T	uc001pgm.2	+	9	3364	c.3094G>T	c.(3094-3096)GAG>TAG	p.E1032*	KIAA1377_uc001pgn.2_Nonsense_Mutation_p.E988*|KIAA1377_uc010run.1_Nonsense_Mutation_p.E833*	NM_020802	NP_065853	Q9P2H0	K1377_HUMAN	hypothetical protein LOC57562	1032							protein binding			breast(2)|ovary(1)|central_nervous_system(1)	4	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		ATCAGTGCCGGAGGATGAGAT	0.363		NaN											1	0	8.73484e-25	0.01441	9.95555e-25	54	144									
ALG9	79796	broad.mit.edu	37	11	111680410	111680410	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:111680410C>G	uc001pmb.2	-	15	1768	c.1669G>C	c.(1669-1671)GAA>CAA	p.E557Q	ALG9_uc001ply.2_Missense_Mutation_p.E386Q|ALG9_uc001plz.2_Missense_Mutation_p.E393Q|ALG9_uc010rwm.1_Missense_Mutation_p.E564Q|ALG9_uc010rwn.1_Missense_Mutation_p.E511Q|ALG9_uc010rwo.1_Missense_Mutation_p.E385Q	NM_001077690	NP_001071158	Q9H6U8	ALG9_HUMAN	asparagine-linked glycosylation 9 protein	557	Lumenal (Potential).				dolichol-linked oligosaccharide biosynthetic process|GPI anchor biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,2-mannosyltransferase activity			large_intestine(1)|ovary(1)	2		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;6.81e-07)|BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|all cancers(92;1.3e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0587)		CTGATCCATTCTTCTTTATTG	0.388		NaN											0	0	0	0.028581	0	14	70									
DSCAML1	57453	broad.mit.edu	37	11	117391942	117391942	+	Silent	SNP	G	G	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:117391942G>T	uc001prh.1	-	6	1298	c.1296C>A	c.(1294-1296)CTC>CTA	p.L432L	DSCAML1_uc001pri.1_Silent_p.L236L	NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	372	Extracellular (Potential).|Ig-like C2-type 4.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CCGAGGTGATGAGCAGCGTCT	0.637		NaN											1	0	2.27781e-18	0.01441	2.58011e-18	44	117									
ETS1	2113	broad.mit.edu	37	11	128354930	128354930	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:128354930G>A	uc010sbs.1	-	5	834	c.518C>T	c.(517-519)TCG>TTG	p.S173L	ETS1_uc001qej.2_Missense_Mutation_p.S217L|ETS1_uc009zch.2_Intron|ETS1_uc009zcg.2_Missense_Mutation_p.S173L	NM_005238	NP_005229	P14921	ETS1_HUMAN	v-ets erythroblastosis virus E26 oncogene	173					cell motility|immune response|induction of apoptosis|negative regulation of cell cycle|negative regulation of cell cycle|negative regulation of cell proliferation|PML body organization|positive regulation of cellular component movement|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|response to antibiotic|transcription from RNA polymerase II promoter	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			lung(4)|central_nervous_system(1)|pleura(1)	6	all_hematologic(175;0.0537)	Lung NSC(97;0.000542)|all_lung(97;0.000665)|Breast(109;0.00765)|all_neural(223;0.0351)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.47e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0174)|LUSC - Lung squamous cell carcinoma(976;0.0815)|Lung(307;0.0833)		TGAGAACTCCGATGGTGGAAC	0.483		NaN											0	0	0	0.023175	0	29	179									
ARHGAP32	9743	broad.mit.edu	37	11	128842725	128842725	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:128842725G>A	uc009zcp.2	-	21	3634	c.3634C>T	c.(3634-3636)CAG>TAG	p.Q1212*	ARHGAP32_uc009zcq.1_3'UTR|ARHGAP32_uc009zco.2_Nonsense_Mutation_p.Q171*|ARHGAP32_uc001qez.2_Nonsense_Mutation_p.Q863*	NM_001142685	NP_001136157	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 1	1212					cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5						GAAGGAGGCTGATCTCCACTG	0.453		NaN											0	0	0	0.0333	0	16	37									
IGSF9B	22997	broad.mit.edu	37	11	133814125	133814125	+	Silent	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:133814125G>A	uc001qgx.3	-	3	630	c.399C>T	c.(397-399)CTC>CTT	p.L133L	IGSF9B_uc001qgz.2_RNA	NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	133	Extracellular (Potential).					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		CGTTGATGGTGAGGTGGACCC	0.602		NaN											0	0	0	0.006214	0	7	25									
GLB1L3	112937	broad.mit.edu	37	11	134162074	134162074	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:134162074G>A	uc009zdf.2	+	8	1138	c.778G>A	c.(778-780)GAG>AAG	p.E260K	GLB1L3_uc010scs.1_Missense_Mutation_p.E260K|GLB1L3_uc010sct.1_Missense_Mutation_p.E112K|GLB1L3_uc010scu.1_5'UTR	NM_001080407	NP_001073876	Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1 like 3	260					carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			pancreas(1)	1	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		CTCTGATGGTGAGAAACATGT	0.473		NaN											0	0	0	0.008871	0	15	26									
CACNA1C	775	broad.mit.edu	37	12	2676892	2676892	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:2676892G>C	uc009zdu.1	+	13	2140	c.1827G>C	c.(1825-1827)AAG>AAC	p.K609N	CACNA1C_uc009zdv.1_Missense_Mutation_p.K606N|CACNA1C_uc001qkb.2_Missense_Mutation_p.K609N|CACNA1C_uc001qkc.2_Missense_Mutation_p.K609N|CACNA1C_uc001qke.2_Missense_Mutation_p.K609N|CACNA1C_uc001qkf.2_Missense_Mutation_p.K609N|CACNA1C_uc001qjz.2_Missense_Mutation_p.K609N|CACNA1C_uc001qkd.2_Missense_Mutation_p.K609N|CACNA1C_uc001qkg.2_Missense_Mutation_p.K609N|CACNA1C_uc009zdw.1_Missense_Mutation_p.K609N|CACNA1C_uc001qkh.2_Missense_Mutation_p.K609N|CACNA1C_uc001qkl.2_Missense_Mutation_p.K609N|CACNA1C_uc001qkn.2_Missense_Mutation_p.K609N|CACNA1C_uc001qko.2_Missense_Mutation_p.K609N|CACNA1C_uc001qkp.2_Missense_Mutation_p.K609N|CACNA1C_uc001qkr.2_Missense_Mutation_p.K609N|CACNA1C_uc001qku.2_Missense_Mutation_p.K609N|CACNA1C_uc001qkq.2_Missense_Mutation_p.K609N|CACNA1C_uc001qks.2_Missense_Mutation_p.K609N|CACNA1C_uc001qkt.2_Missense_Mutation_p.K609N|CACNA1C_uc001qka.1_Missense_Mutation_p.K144N|CACNA1C_uc001qki.1_Missense_Mutation_p.K345N|CACNA1C_uc001qkj.1_Missense_Mutation_p.K345N|CACNA1C_uc001qkk.1_Missense_Mutation_p.K345N|CACNA1C_uc001qkm.1_Missense_Mutation_p.K345N	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	609	II.|Extracellular (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	TGGAGACCAAGATCATGTCCC	0.587		NaN											0	0	0	0.009096	0	4	39									
GNB3	2784	broad.mit.edu	37	12	6952355	6952355	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:6952355C>T	uc001qrd.2	+	6	626	c.221C>T	c.(220-222)TCG>TTG	p.S74L	GNB3_uc001qrc.2_Missense_Mutation_p.S30L|GNB3_uc009zfe.2_Missense_Mutation_p.S74L	NM_002075	NP_002066	P16520	GBB3_HUMAN	guanine nucleotide-binding protein, beta-3	74	WD 1.				cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of blood pressure|synaptic transmission	plasma membrane	GTPase activity|GTPase binding|signal transducer activity				0						GTAAGTGCCTCGCAAGATGGG	0.612		NaN											0	0	0	0.023175	0	33	219									
SLC2A3	6515	broad.mit.edu	37	12	8078455	8078455	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:8078455G>C	uc001qtr.2	-	7	1213	c.951C>G	c.(949-951)ATC>ATG	p.I317M		NM_006931	NP_008862	P11169	GTR3_HUMAN	solute carrier family 2 (facilitated glucose	317	Helical; Name=8; (Potential).				carbohydrate metabolic process|water-soluble vitamin metabolic process	integral to membrane|plasma membrane	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			ovary(3)|pancreas(1)	4				Kidney(36;0.0866)		CTACAGTGAAGATAGTATTAA	0.433		NaN											0	0	0	0.008871	0	16	163									
ABCC9	10060	broad.mit.edu	37	12	22068679	22068679	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:22068679C>A	uc001rfi.1	-	5	759	c.739G>T	c.(739-741)GCA>TCA	p.A247S	ABCC9_uc001rfh.2_Missense_Mutation_p.A247S|ABCC9_uc001rfj.1_Missense_Mutation_p.A247S	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	247	Cytoplasmic (Potential).				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TTTCCAATTGCCTTCAGATCA	0.363		NaN											1	0	9.24413e-38	0.01441	1.07361e-37	92	72									
FGD4	121512	broad.mit.edu	37	12	32729320	32729320	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:32729320C>G	uc001rkz.2	+	3	506	c.29C>G	c.(28-30)TCT>TGT	p.S10C	FGD4_uc001rlc.2_Missense_Mutation_p.S95C|FGD4_uc001rky.2_5'UTR|FGD4_uc001rla.2_5'UTR|FGD4_uc010ske.1_Missense_Mutation_p.S122C|FGD4_uc001rkx.3_Missense_Mutation_p.S10C	NM_139241	NP_640334	Q96M96	FGD4_HUMAN	FYVE, RhoGEF and PH domain containing 4	10	Actin filament-binding (By similarity).				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|filopodium|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)					GCCTCTGCTTCTTGTGTCTCA	0.443		NaN											0	0	0	0.014323	0	18	68									
ADAMTS20	80070	broad.mit.edu	37	12	43750291	43750291	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:43750291G>A	uc010skx.1	-	38	5639	c.5639C>T	c.(5638-5640)TCA>TTA	p.S1880L		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	1880	GON.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		ACTTACCTCTGATCTTCGTAT	0.408		NaN											0	0	0	0.021553	0	5	9									
ADAMTS20	80070	broad.mit.edu	37	12	43822323	43822323	+	Silent	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:43822323G>A	uc010skx.1	-	26	3666	c.3666C>T	c.(3664-3666)TCC>TCT	p.S1222S	ADAMTS20_uc001rno.1_Silent_p.S340S|ADAMTS20_uc001rnp.1_Silent_p.S376S	NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	1222	TSP type-1 8.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CATGGCCACAGGAAGCTGAAC	0.308		NaN											0	0	0	0.00308	0	7	15									
SENP1	29843	broad.mit.edu	37	12	48482596	48482596	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:48482596C>T	uc001rqx.2	-	5	814	c.368G>A	c.(367-369)CGA>CAA	p.R123Q	SENP1_uc001rqw.2_Missense_Mutation_p.R123Q|SENP1_uc001rqy.2_5'UTR|SENP1_uc001rqz.2_5'UTR|SENP1_uc009zkx.2_Missense_Mutation_p.R123Q	NM_014554	NP_055369	Q9P0U3	SENP1_HUMAN	sentrin/SUMO-specific protease 1	123	Ser-rich.				activation of caspase activity|induction of apoptosis by extracellular signals|protein desumoylation|proteolysis	cytoplasm|nucleus	endopeptidase activity|SUMO-specific protease activity			pancreas(2)|lung(1)	3		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)				TGAGGTCTTTCGGGTTTCGAG	0.403		NaN											0	0	0	0.02938	0	5	6									
METTL7A	25840	broad.mit.edu	37	12	51319031	51319031	+	Silent	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:51319031G>A	uc001rxb.2	+	1	498	c.210G>A	c.(208-210)GGG>GGA	p.G70G	METTL7A_uc010smv.1_Silent_p.G70G	NM_014033	NP_054752	Q9H8H3	MET7A_HUMAN	methyltransferase like 7A precursor	70						endoplasmic reticulum|lipid particle|membrane	methyltransferase activity				0						GCCCCTCCGGGAAACTCTCCC	0.562		NaN											0	0	0	0.014758	0	4	24									
METTL7A	25840	broad.mit.edu	37	12	51319142	51319142	+	Silent	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:51319142G>A	uc001rxb.2	+	1	609	c.321G>A	c.(319-321)TTG>TTA	p.L107L	METTL7A_uc010smv.1_Intron	NM_014033	NP_054752	Q9H8H3	MET7A_HUMAN	methyltransferase like 7A precursor	107						endoplasmic reticulum|lipid particle|membrane	methyltransferase activity				0						AGAAGTTTTTGATCAAGAGCA	0.557		NaN											0	0	0	0.013537	0	11	44									
ZNF740	283337	broad.mit.edu	37	12	53579200	53579200	+	Silent	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:53579200G>A	uc001scb.3	+	4	583	c.189G>A	c.(187-189)CGG>CGA	p.R63R		NM_001004304	NP_001004304	Q8NDX6	ZN740_HUMAN	zinc finger protein 740	63					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|protein binding|zinc ion binding				0						ATAAGTCCCGGAGCCGCAAAG	0.453		NaN											0	0	0	0.013537	0	10	22									
ERBB3	2065	broad.mit.edu	37	12	56482341	56482341	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:56482341G>T	uc001sjh.2	+	8	1082	c.889G>T	c.(889-891)GAT>TAT	p.D297Y	ERBB3_uc009zoj.2_RNA|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Missense_Mutation_p.D238Y|ERBB3_uc001sji.2_5'UTR	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	297	Extracellular (Potential).				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			CTTTGTGGTGGATCAAACATC	0.512		NaN											1	0	4.0181e-32	0.01441	4.65187e-32	41	169									
CS	1431	broad.mit.edu	37	12	56667506	56667506	+	Silent	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:56667506C>T	uc001sks.1	-	10	1285	c.1095G>A	c.(1093-1095)CTG>CTA	p.L365L	CS_uc010sql.1_Silent_p.L352L|CS_uc001skr.1_Silent_p.L299L|CS_uc001skt.1_Silent_p.L320L|CS_uc010sqm.1_3'UTR	NM_004077	NP_004068	O75390	CISY_HUMAN	citrate synthase precursor	365					cellular carbohydrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	citrate (Si)-synthase activity				0		Myeloproliferative disorder(1001;0.000374)		BRCA - Breast invasive adenocarcinoma(357;6.17e-07)		GCAGGTGTTTCAGAGCAAACT	0.468		NaN											0	0	0	0.009535	0	25	86									
GLIPR1	11010	broad.mit.edu	37	12	75875733	75875733	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:75875733G>C	uc001sxs.2	+	2	442	c.294G>C	c.(292-294)GAG>GAC	p.E98D	GLIPR1_uc009zsb.1_Missense_Mutation_p.E98D	NM_006851	NP_006842	P48060	GLIP1_HUMAN	GLI pathogenesis-related 1 precursor	98					cellular lipid metabolic process	extracellular region|integral to membrane				large_intestine(1)|ovary(1)|skin(1)	3						CACTGGGAGAGAACATCTGGA	0.483		NaN											0	0	0	0.01892	0	19	78									
NAV3	89795	broad.mit.edu	37	12	78513485	78513485	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:78513485C>G	uc001syp.2	+	15	3682	c.3509C>G	c.(3508-3510)TCT>TGT	p.S1170C	NAV3_uc001syo.2_Missense_Mutation_p.S1170C|NAV3_uc010sub.1_Missense_Mutation_p.S670C|NAV3_uc009zsf.2_Missense_Mutation_p.S178C	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1170	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						AGCAGCAAGTCTGCTGGGGCC	0.537		NaN								HNSCC(70;0.22)			0	0	0	0.004482	0	8	41									
ACSS3	79611	broad.mit.edu	37	12	81503360	81503360	+	Silent	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:81503360C>T	uc001szl.1	+	2	424	c.333C>T	c.(331-333)AAC>AAT	p.N111N	ACSS3_uc001szm.1_Silent_p.N110N	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	111						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						GAATGCTTAACATTTGTTACA	0.313		NaN											0	0	0	0.006214	0	7	61									
TMTC3	160418	broad.mit.edu	37	12	88584258	88584258	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:88584258G>A	uc001tau.2	+	12	1785	c.1565G>A	c.(1564-1566)AGA>AAA	p.R522K		NM_181783	NP_861448	Q6ZXV5	TMTC3_HUMAN	transmembrane and tetratricopeptide repeat	522						integral to membrane	binding			skin(1)	1						TATGCAGCCAGAATTGCCCCT	0.373		NaN											0	0	0	0.028581	0	11	68									
MTERFD3	80298	broad.mit.edu	37	12	107372423	107372423	+	Missense_Mutation	SNP	G	G	C	rs139694986	byFrequency	TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:107372423G>C	uc001tme.1	-	2	1889	c.70C>G	c.(70-72)CCA>GCA	p.P24A	MTERFD3_uc001tmf.1_Missense_Mutation_p.P24A|MTERFD3_uc001tmg.1_Missense_Mutation_p.P24A|MTERFD3_uc001tmh.1_Missense_Mutation_p.P24A	NM_025198	NP_079474	Q49AM1	MTER3_HUMAN	transcription termination factor-like protein	24					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial nucleoid	transcription regulatory region DNA binding				0						CTGTATTTTGGAGGTGATCGC	0.433		NaN											0	0	0	0.021553	0	6	47									
ACACB	32	broad.mit.edu	37	12	109702924	109702924	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:109702924G>C	uc001tob.2	+	51	7071	c.6952G>C	c.(6952-6954)GAG>CAG	p.E2318Q	ACACB_uc001toc.2_Missense_Mutation_p.E2318Q|ACACB_uc001tod.2_RNA|ACACB_uc010sxm.1_Missense_Mutation_p.E984Q	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	2318					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	GGACATCCTGGAGTGGAAGAC	0.647		NaN											0	0	0	0.01441	0	51	131									
GCN1L1	10985	broad.mit.edu	37	12	120576588	120576588	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:120576588C>T	uc001txo.2	-	46	6080	c.6067G>A	c.(6067-6069)GAG>AAG	p.E2023K		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	2023	HEAT 17.				regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GCTGCCGCCTCTCTGACCTCC	0.547		NaN											0	0	0	0.01441	0	63	151									
RILPL1	353116	broad.mit.edu	37	12	123970241	123970241	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:123970241C>T	uc001ufe.2	-	5	1149	c.913G>A	c.(913-915)GAG>AAG	p.E305K	RILPL1_uc001ufd.2_Missense_Mutation_p.E154K|RILPL1_uc010tas.1_Missense_Mutation_p.E305K	NM_178314	NP_847884	Q5EBL4	RIPL1_HUMAN	Rab interacting lysosomal protein-like 1	305	RILP-like.				neuroprotection	cytosol					0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000224)|Epithelial(86;0.00067)|all cancers(50;0.00836)|BRCA - Breast invasive adenocarcinoma(302;0.197)		TCGTTCCTCTCGTGCAGCACG	0.622		NaN											0	0	0	0.004482	0	6	47									
TMEM132B	114795	broad.mit.edu	37	12	125834138	125834138	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:125834138A>G	uc001uhe.1	+	2	201	c.193A>G	c.(193-195)AGT>GGT	p.S65G		NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	65	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		AAGGAACTCCAGTCTGCAGGC	0.522		NaN											0	0	0	0.037714	0	22	137									
POLE	5426	broad.mit.edu	37	12	133252767	133252767	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:133252767C>G	uc001uks.1	-	10	977	c.933G>C	c.(931-933)GAG>GAC	p.E311D	POLE_uc010tbq.1_RNA|POLE_uc009zyu.1_Missense_Mutation_p.E284D	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	311					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		CTGAAACAATCTCCCTGTTGG	0.478		NaN						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.004482	0	7	68									
CHFR	55743	broad.mit.edu	37	12	133433181	133433181	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:133433181C>G	uc001ulf.2	-	10	1222	c.1138G>C	c.(1138-1140)GAT>CAT	p.D380H	CHFR_uc001ulc.1_RNA|CHFR_uc001ule.2_Missense_Mutation_p.D368H|CHFR_uc010tbs.1_Missense_Mutation_p.D380H|CHFR_uc001uld.2_Missense_Mutation_p.D339H|CHFR_uc010tbt.1_Missense_Mutation_p.D288H	NM_001161344	NP_001154816	Q96EP1	CHFR_HUMAN	checkpoint with forkhead and ring finger domains	380					cell division|mitosis|mitotic cell cycle checkpoint|modification-dependent protein catabolic process|protein polyubiquitination	PML body	nucleotide binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(1)	1	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.00552)|all_epithelial(31;0.226)		OV - Ovarian serous cystadenocarcinoma(86;2.59e-08)|Epithelial(86;6.38e-07)|all cancers(50;1.56e-05)		TTTCTGGCATCCATACTTTGC	0.493		NaN											0	0	0	0.01441	0	61	199									
IFT88	8100	broad.mit.edu	37	13	21212522	21212522	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr13:21212522G>C	uc001unh.2	+	19	1861	c.1465G>C	c.(1465-1467)GAT>CAT	p.D489H	IFT88_uc001uni.2_Missense_Mutation_p.D480H|IFT88_uc001unj.2_Missense_Mutation_p.D479H|IFT88_uc010tcq.1_Missense_Mutation_p.D460H|IFT88_uc001unk.2_Missense_Mutation_p.D235H	NM_175605	NP_783195	Q13099	IFT88_HUMAN	intraflagellar transport 88 homolog isoform 1	489	TPR 6.				cilium morphogenesis	centriole|intraflagellar transport particle B|microtubule basal body|microtubule-based flagellum	protein binding			ovary(1)	1		all_cancers(29;5.79e-25)|all_epithelial(30;2.57e-20)|all_lung(29;3.13e-16)|Lung SC(185;0.0262)|Ovarian(182;0.0825)|Hepatocellular(188;0.244)		all cancers(112;0.000667)|Epithelial(112;0.00119)|OV - Ovarian serous cystadenocarcinoma(117;0.0141)|Lung(94;0.0183)|LUSC - Lung squamous cell carcinoma(192;0.0528)		TGTGAACTCTGATAGATATAA	0.338		NaN											0	0	0	0.020292	0	10	108									
FRY	10129	broad.mit.edu	37	13	32841395	32841395	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr13:32841395G>A	uc001utx.2	+	55	8531	c.8035G>A	c.(8035-8037)GAT>AAT	p.D2679N	FRY_uc010tdw.1_RNA|FRY_uc001uty.2_Missense_Mutation_p.D234N|FRY_uc001utz.2_Missense_Mutation_p.D204N|FRY_uc010tdx.1_Missense_Mutation_p.D49N	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	2679					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		AGCCTGTGACGATGCCGAGGA	0.547		NaN											0	0	0	0.01892	0	25	118									
MED4	29079	broad.mit.edu	37	13	48660459	48660459	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr13:48660459G>A	uc001vby.1	-	3	348	c.322C>T	c.(322-324)CAG>TAG	p.Q108*	MED4_uc010tge.1_Nonsense_Mutation_p.Q108*|MED4_uc010tgf.1_Nonsense_Mutation_p.Q62*	NM_014166	NP_054885	Q9NPJ6	MED4_HUMAN	mediator complex subunit 4	108	Potential.				androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)	1		all_cancers(8;2.93e-25)|all_epithelial(8;4.38e-13)|all_lung(13;7.37e-06)|all_hematologic(8;8.61e-05)|Breast(56;0.000141)|Lung NSC(96;0.000518)|Prostate(109;0.00132)|Acute lymphoblastic leukemia(8;0.00559)|Myeloproliferative disorder(33;0.039)|Hepatocellular(98;0.0556)|Lung SC(185;0.102)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(144;5.18e-07)		TGTAGCTGCTGAATATCACTG	0.338		NaN											0	0	0	0.012319	0	18	99									
RB1	5925	broad.mit.edu	37	13	49027133	49027133	+	Missense_Mutation	SNP	C	C	T	rs137853292		TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr13:49027133C>T	uc001vcb.2	+	18	1866	c.1700C>T	c.(1699-1701)TCA>TTA	p.S567L		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	567	Domain A.|Pocket; binds T and E1A.		S -> L (in RB).		androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(6)|p.S567*(1)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ATATAGGATTCACCTTTATTT	0.333		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			0	0	0	0.0333	0	16	34									
RB1	5925	broad.mit.edu	37	13	49027219	49027219	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr13:49027219C>G	uc001vcb.2	+	18	1952	c.1786C>G	c.(1786-1788)CTC>GTC	p.L596V		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	596	Pocket; binds T and E1A.|Spacer.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(6)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TAATCTTCCTCTCCAGAATAA	0.338		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			0	0	0	0.010818	0	27	50									
OLFM4	10562	broad.mit.edu	37	13	53602986	53602986	+	Silent	SNP	C	C	T	rs149259735		TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr13:53602986C>T	uc001vhl.2	+	1	15	c.15C>T	c.(13-15)CTC>CTT	p.L5L	OLFM4_uc001vhk.1_Silent_p.L5L	NM_006418	NP_006409	Q6UX06	OLFM4_HUMAN	olfactomedin 4 precursor	5					cell adhesion	extracellular space				skin(1)	1		Breast(56;0.000776)|Lung NSC(96;0.000814)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.13e-08)		GGCCCGGCCTCTCATTTCTCC	0.592		NaN											0	0	0	0.01441	0	56	121									
MYCBP2	23077	broad.mit.edu	37	13	77786175	77786175	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr13:77786175G>T	uc001vkf.2	-	23	3155	c.3064C>A	c.(3064-3066)CAA>AAA	p.Q1022K	MYCBP2_uc010aev.2_Missense_Mutation_p.Q426K	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	1022	RCC1 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		AAAAAAGTTTGGTCCCCACTT	0.358		NaN											1	0	0.000602214	0.014758	0.000617354	5	57									
ADCY4	196883	broad.mit.edu	37	14	24801042	24801042	+	Silent	SNP	G	G	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr14:24801042G>T	uc001wov.2	-	4	627	c.621C>A	c.(619-621)CTC>CTA	p.L207L	ADCY4_uc001wow.2_Silent_p.L207L|ADCY4_uc010toh.1_5'UTR|ADCY4_uc001wox.2_Silent_p.L207L|ADCY4_uc001woy.2_Silent_p.L207L	NM_139247	NP_640340	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	207	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			ovary(1)|lung(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(265;0.0192)		GCAGGGAGCTGAGTGCCTCCC	0.567		NaN											1	0	5.9392e-07	0.021553	6.31793e-07	4	30									
NFKBIA	4792	broad.mit.edu	37	14	35873730	35873730	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr14:35873730C>T	uc001wtf.3	-	1	231	c.121G>A	c.(121-123)GAG>AAG	p.E41K	NFKBIA_uc001wte.3_5'Flank|NFKBIA_uc001wtg.3_Missense_Mutation_p.E41K|NFKBIA_uc010amo.2_RNA	NM_020529	NP_065390	P25963	IKBA_HUMAN	nuclear factor of kappa light polypeptide gene	41					anti-apoptosis|apoptosis|cellular response to cold|cytoplasmic sequestering of NF-kappaB|innate immune response|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of DNA binding|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|negative regulation of NF-kappaB transcription factor activity|nerve growth factor receptor signaling pathway|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|I-kappaB/NF-kappaB complex|nucleus|plasma membrane	identical protein binding|NF-kappaB binding|nuclear localization sequence binding|ubiquitin protein ligase binding			breast(2)	2	Breast(36;0.0484)|Hepatocellular(127;0.158)		Lung(238;9.25e-06)|LUAD - Lung adenocarcinoma(48;1.53e-05)|Epithelial(34;0.00314)|all cancers(34;0.00891)	GBM - Glioblastoma multiforme(112;0.0222)		TGCTCGTACTCCTCGTCTTTC	0.687		NaN											0	0	0	0.021553	0	6	16									
TXNDC16	57544	broad.mit.edu	37	14	52922155	52922155	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr14:52922155G>A	uc001wzs.2	-	18	2178	c.1729C>T	c.(1729-1731)CCA>TCA	p.P577S	TXNDC16_uc010tqu.1_Missense_Mutation_p.P572S|TXNDC16_uc010aoe.2_RNA	NM_020784	NP_065835	Q9P2K2	TXD16_HUMAN	thioredoxin domain containing 16 isoform 1	577					cell redox homeostasis	extracellular region					0	Breast(41;0.0716)					AGCAGGGCTGGAAGACTTGCA	0.418		NaN											0	0	0	0.01441	0	57	54									
DLGAP5	9787	broad.mit.edu	37	14	55618599	55618599	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr14:55618599G>C	uc001xbs.2	-	17	2399	c.2182C>G	c.(2182-2184)CTT>GTT	p.L728V	DLGAP5_uc001xbt.2_Missense_Mutation_p.L728V	NM_014750	NP_055565	Q15398	DLGP5_HUMAN	discs large homolog 7 isoform a	728					cell proliferation|cell-cell signaling|mitotic chromosome movement towards spindle pole|positive regulation of mitotic metaphase/anaphase transition	nucleus|spindle pole centrosome	phosphoprotein phosphatase activity|protein binding			ovary(1)|skin(1)	2						CCAGCAAGAAGAGGCAAACTC	0.328		NaN											0	0	0	0.011902	0	43	43									
DAAM1	23002	broad.mit.edu	37	14	59835468	59835468	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr14:59835468G>T	uc001xdz.1	+	26	3253	c.3128G>T	c.(3127-3129)GGA>GTA	p.G1043V	DAAM1_uc001xea.1_Missense_Mutation_p.G1033V|DAAM1_uc001xec.1_RNA	NM_014992	NP_055807	Q9Y4D1	DAAM1_HUMAN	dishevelled-associated activator of	1043	DAD.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.165)		TTACGCTCAGGAGAAGTGTTT	0.403		NaN											1	0	2.54651e-27	0.027894	2.92968e-27	38	27									
MTMR10	54893	broad.mit.edu	37	15	31233969	31233969	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr15:31233969G>A	uc001zfh.1	-	16	2136	c.2038C>T	c.(2038-2040)CAC>TAC	p.H680Y	MTMR15_uc001zff.2_3'UTR|MTMR15_uc001zfe.2_3'UTR|MTMR10_uc010ubk.1_Missense_Mutation_p.H94Y|MTMR10_uc001zfg.1_Missense_Mutation_p.H261Y|MTMR10_uc010azx.1_Missense_Mutation_p.H432Y|MTMR10_uc001zfi.1_3'UTR	NM_017762	NP_060232	Q9NXD2	MTMRA_HUMAN	myotubularin related protein 10	680							phosphatase activity			ovary(1)	1		all_lung(180;2.81e-11)		all cancers(64;7.26e-15)|Epithelial(43;7.2e-11)|GBM - Glioblastoma multiforme(186;0.000158)|BRCA - Breast invasive adenocarcinoma(123;0.00426)|Lung(196;0.174)		GAGAGCTTGTGAAAGGCTGTG	0.602		NaN											0	0	0	0.028581	0	14	19									
STRC	161497	broad.mit.edu	37	15	43910137	43910137	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr15:43910137C>T	uc001zsf.2	-	2	560	c.482G>A	c.(481-483)TGC>TAC	p.C161Y	STRC_uc010bdl.2_5'UTR|STRC_uc010udz.1_RNA|STRC_uc001zsg.1_Missense_Mutation_p.C87Y	NM_153700	NP_714544	Q7RTU9	STRC_HUMAN	stereocilin precursor	161					sensory perception of sound	cell surface					0		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		ATCACGGGTGCATGGGGGCCG	0.637		NaN											0	0	0	0.007413	0	13	122									
SEMA6D	80031	broad.mit.edu	37	15	48052505	48052505	+	Silent	SNP	A	A	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr15:48052505A>T	uc010bek.2	+	3	474	c.114A>T	c.(112-114)TCA>TCT	p.S38S	SEMA6D_uc001zvw.2_Silent_p.S38S|SEMA6D_uc001zvx.1_Silent_p.S38S|SEMA6D_uc001zvy.2_Silent_p.S38S|SEMA6D_uc001zvz.2_Silent_p.S38S|SEMA6D_uc001zwa.2_Silent_p.S38S|SEMA6D_uc001zwb.2_Silent_p.S38S|SEMA6D_uc001zwc.2_Silent_p.S38S	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	38	Sema.|Extracellular (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		TTGCAGATTCAAGGCAATATC	0.413		NaN											0	0	0	0.010729	0	11	54									
ITGA11	22801	broad.mit.edu	37	15	68649637	68649637	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr15:68649637C>A	uc002ari.2	-	7	688	c.601G>T	c.(601-603)GTT>TTT	p.V201F	ITGA11_uc010bib.2_Missense_Mutation_p.V201F	NM_001004439	NP_001004439	Q9UKX5	ITA11_HUMAN	integrin, alpha 11 precursor	201	VWFA.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			kidney(2)|pancreas(1)	3					Tirofiban(DB00775)	ACAACTCCAACCTGCAAGGGA	0.498		NaN											1	0	2.27525e-19	0.021523	2.5852e-19	17	76									
PTPN9	5780	broad.mit.edu	37	15	75819584	75819584	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr15:75819584C>T	uc002bal.2	-	2	590	c.82G>A	c.(82-84)GAA>AAA	p.E28K		NM_002833	NP_002824	P43378	PTN9_HUMAN	protein tyrosine phosphatase, non-receptor type	28						cytoplasmic part	non-membrane spanning protein tyrosine phosphatase activity|protein binding			lung(1)|skin(1)	2						TTAATCTCTTCGAGAAACTGC	0.398		NaN											0	0	0	0.02938	0	6	63									
SGK269	79834	broad.mit.edu	37	15	77472021	77472021	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr15:77472021C>T	uc002bcm.2	-	3	2556	c.2248G>A	c.(2248-2250)GAG>AAG	p.E750K	SGK269_uc002bcn.2_Missense_Mutation_p.E750K	NM_024776	NP_079052	Q9H792	PEAK1_HUMAN	NKF3 kinase family member	750					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding				0				STAD - Stomach adenocarcinoma(199;0.124)		ATCTGAGACTCCTGAGTGCCT	0.527		NaN											0	0	0	0.006214	0	8	77									
TM6SF1	53346	broad.mit.edu	37	15	83776476	83776476	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr15:83776476C>T	uc002bjp.2	+	1	153	c.44C>T	c.(43-45)TCG>TTG	p.S15L	TM6SF1_uc010bmq.2_Missense_Mutation_p.S15L|TM6SF1_uc002bjq.2_Missense_Mutation_p.S15L|TM6SF1_uc010bmr.2_RNA	NM_023003	NP_075379	Q9BZW5	TM6S1_HUMAN	transmembrane 6 superfamily member 1 isoform 1	15	Helical; (Potential).					integral to membrane				ovary(1)	1						CTGTCCCTCTCGGCCATCCCG	0.567		NaN											0	0	0	0.004672	0	3	15									
ITFG3	83986	broad.mit.edu	37	16	304468	304468	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr16:304468G>C	uc002cgf.2	+	3	251	c.56G>C	c.(55-57)AGA>ACA	p.R19T	ITFG3_uc010bqr.2_Intron|ITFG3_uc002cgg.2_Missense_Mutation_p.R19T|ITFG3_uc010uud.1_RNA|ITFG3_uc002cgh.2_Missense_Mutation_p.R19T	NM_032039	NP_114428	Q9H0X4	ITFG3_HUMAN	integrin alpha FG-GAP repeat containing 3	19	Cytoplasmic (Potential).					integral to membrane				central_nervous_system(1)	1		all_cancers(16;0.000129)|all_epithelial(16;0.000206)|Hepatocellular(16;0.00264)|Lung NSC(18;0.0626)|all_lung(18;0.13)				AATGAAGAAAGAAAATCGCAG	0.502		NaN									OREG0003695	type=REGULATORY REGION|Gene=C16orf9|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	0	0	0	0.01441	0	43	138									
ITFG3	83986	broad.mit.edu	37	16	304632	304632	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr16:304632G>A	uc002cgf.2	+	3	415	c.220G>A	c.(220-222)GAC>AAC	p.D74N	ITFG3_uc010bqr.2_Intron|ITFG3_uc002cgg.2_Missense_Mutation_p.D74N|ITFG3_uc010uud.1_RNA|ITFG3_uc002cgh.2_Missense_Mutation_p.D74N	NM_032039	NP_114428	Q9H0X4	ITFG3_HUMAN	integrin alpha FG-GAP repeat containing 3	74	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1		all_cancers(16;0.000129)|all_epithelial(16;0.000206)|Hepatocellular(16;0.00264)|Lung NSC(18;0.0626)|all_lung(18;0.13)				CCCGTGTCCAGACCGGCCGGC	0.607		NaN											0	0	0	0.01441	0	59	287									
GRIN2A	2903	broad.mit.edu	37	16	9862756	9862756	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr16:9862756G>T	uc002czo.3	-	12	3095	c.2547C>A	c.(2545-2547)TTC>TTA	p.F849L	GRIN2A_uc010uym.1_Missense_Mutation_p.F849L|GRIN2A_uc010uyn.1_Missense_Mutation_p.F692L|GRIN2A_uc002czr.3_Missense_Mutation_p.F849L	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	849	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	ACACGCCCGTGAAACAGAAGC	0.572		NaN											1	0	7.41877e-09	0.012319	8.0792e-09	20	57									
UQCRC2	7385	broad.mit.edu	37	16	21985248	21985248	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr16:21985248C>G	uc002djx.2	+	11	1134	c.998C>G	c.(997-999)TCT>TGT	p.S333C	UQCRC2_uc002djy.2_Missense_Mutation_p.S333C|UQCRC2_uc010bxa.2_Intron|UQCRC2_uc002djz.1_Missense_Mutation_p.S200C	NM_003366	NP_003357	P22695	QCR2_HUMAN	ubiquinol-cytochrome c reductase core protein II	333					aerobic respiration|oxidative phosphorylation|proteolysis|respiratory electron transport chain|transport		metalloendopeptidase activity|zinc ion binding			large_intestine(2)	2				GBM - Glioblastoma multiforme(48;0.0264)		TACTCAGATTCTGGACTCTTT	0.388		NaN											0	0	0	0.024245	0	14	57									
GTF3C1	2975	broad.mit.edu	37	16	27518439	27518439	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr16:27518439C>G	uc002dov.1	-	9	1321	c.1281G>C	c.(1279-1281)AAG>AAC	p.K427N	GTF3C1_uc002dou.2_Missense_Mutation_p.K427N	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	427						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						AGGAAATGTACTTGGTGGTTC	0.552		NaN											0	0	0	0.016522	0	18	80									
SNX20	124460	broad.mit.edu	37	16	50709713	50709713	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr16:50709713G>C	uc002egk.2	-	3	423	c.250C>G	c.(250-252)CGC>GGC	p.R84G	SNX20_uc010vgp.1_Missense_Mutation_p.R84G|SNX20_uc002egi.3_Missense_Mutation_p.R84G	NM_182854	NP_878274	Q7Z614	SNX20_HUMAN	sorting nexin 20 isoform 1	84	PX.				cell communication|protein transport	endosome membrane|nucleus|plasma membrane	phosphatidylinositol binding|protein binding			ovary(1)	1						TCCTCGATGCGAGCTGAAGCG	0.418		NaN											0	0	0	0.012319	0	17	115									
CHD9	80205	broad.mit.edu	37	16	53288443	53288443	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr16:53288443C>T	uc002ehb.2	+	17	4119	c.3955C>T	c.(3955-3957)CGA>TGA	p.R1319*	CHD9_uc002egy.2_Nonsense_Mutation_p.R1319*|CHD9_uc002ehc.2_Nonsense_Mutation_p.R1319*|CHD9_uc002ehf.2_Nonsense_Mutation_p.R433*|CHD9_uc002ehd.2_Nonsense_Mutation_p.R845*	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	1319	Helicase C-terminal.				cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				GATGTTTGACCGAGCCAGTTT	0.413		NaN											0	0	0	0.012213	0	31	176									
SETD6	79918	broad.mit.edu	37	16	58552747	58552747	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr16:58552747G>C	uc002ens.2	+	8	1295	c.1236G>C	c.(1234-1236)TGG>TGC	p.W412C	SETD6_uc002enr.2_Missense_Mutation_p.W388C|SETD6_uc010cdm.2_RNA	NM_001160305	NP_001153777	Q8TBK2	SETD6_HUMAN	SET domain containing 6 isoform a	412					negative regulation of NF-kappaB transcription factor activity|peptidyl-lysine monomethylation|regulation of inflammatory response	nucleus	NF-kappaB binding|protein-lysine N-methyltransferase activity			ovary(1)	1						AAGCATCGTGGAGACAGCTGC	0.453		NaN											0	0	0	0.016522	0	19	64									
EDC4	23644	broad.mit.edu	37	16	67912685	67912685	+	Silent	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr16:67912685C>G	uc002eur.2	+	11	1396	c.1230C>G	c.(1228-1230)CTC>CTG	p.L410L	EDC4_uc010cer.2_Silent_p.L29L|EDC4_uc010vkg.1_Silent_p.L342L|EDC4_uc010ces.1_Silent_p.L253L|EDC4_uc002eus.2_Silent_p.L140L	NM_014329	NP_055144	Q6P2E9	EDC4_HUMAN	autoantigen RCD8	410					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|central_nervous_system(2)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		CCCCTAGCCTCAAGGTTTGCT	0.517		NaN											0	0	0	0.01441	0	38	252									
EDC4	23644	broad.mit.edu	37	16	67912931	67912931	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr16:67912931C>A	uc002eur.2	+	12	1525	c.1359C>A	c.(1357-1359)TTC>TTA	p.F453L	EDC4_uc010cer.2_Missense_Mutation_p.F72L|EDC4_uc010vkg.1_Missense_Mutation_p.F385L|EDC4_uc010ces.1_Missense_Mutation_p.F296L|EDC4_uc002eus.2_Missense_Mutation_p.F183L	NM_014329	NP_055144	Q6P2E9	EDC4_HUMAN	autoantigen RCD8	453					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|central_nervous_system(2)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		TCTCGGAGTTCCTGCTCACCC	0.592		NaN											1	0	1.3612e-06	0.024245	1.43966e-06	14	53									
HYDIN	54768	broad.mit.edu	37	16	71004428	71004428	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr16:71004428C>T	uc002ezr.2	-	36	5739	c.5611G>A	c.(5611-5613)GAA>AAA	p.E1871K		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	1872										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				CTCACCTTTTCTTCTATGAGA	0.418		NaN											0	0	0	0.007413	0	13	40									
ANKRD11	29123	broad.mit.edu	37	16	89351727	89351727	+	Nonsense_Mutation	SNP	G	G	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr16:89351727G>C	uc002fmx.1	-	9	1684	c.1223C>G	c.(1222-1224)TCA>TGA	p.S408*	ANKRD11_uc002fmy.1_Nonsense_Mutation_p.S408*|ANKRD11_uc002fnc.1_Nonsense_Mutation_p.S408*|ANKRD11_uc002fnb.1_Nonsense_Mutation_p.S365*	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	408						nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		CGACGTGTCTGACAGGATACG	0.468		NaN											0	0	0	0.00308	0	7	62									
MYO1C	4641	broad.mit.edu	37	17	1386204	1386204	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:1386204C>T	uc002fsp.2	-	4	717	c.497G>A	c.(496-498)CGC>CAC	p.R166H	MYO1C_uc002fsn.2_Missense_Mutation_p.R147H|MYO1C_uc002fso.2_Missense_Mutation_p.R131H|MYO1C_uc010vqj.1_Missense_Mutation_p.R131H|MYO1C_uc010vqk.1_Missense_Mutation_p.R142H	NM_001080779	NP_001074248	O00159	MYO1C_HUMAN	myosin IC isoform a	166	Myosin head-like.				mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity				0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		GGCACCTCCGCGCTCGGGGGC	0.617		NaN											0	0	0	0.024245	0	14	29									
ATP2A3	489	broad.mit.edu	37	17	3831578	3831578	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:3831578C>G	uc002fxb.1	-	21	3175	c.3024G>C	c.(3022-3024)TGG>TGC	p.W1008C	ATP2A3_uc010ckn.1_Intron|ATP2A3_uc002fwx.1_Missense_Mutation_p.W1008C|ATP2A3_uc002fwy.1_Missense_Mutation_p.W1008C|ATP2A3_uc002fwz.1_Missense_Mutation_p.W1008C|ATP2A3_uc002fxa.1_Missense_Mutation_p.W1008C|ATP2A3_uc002fxc.1_Intron|ATP2A3_uc002fxd.1_Intron	NM_174955	NP_777615	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous isoform b	1008	Cytoplasmic (By similarity).				ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			ovary(3)|breast(1)|central_nervous_system(1)	5				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		GCTGCCTACTCCAGGCCTGCG	0.612		NaN											0	0	0	0.006122	0	14	57									
CYB5D2	124936	broad.mit.edu	37	17	4060176	4060176	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:4060176G>A	uc002fxm.3	+	4	1183	c.595G>A	c.(595-597)GAC>AAC	p.D199N	CYB5D2_uc010cko.2_Missense_Mutation_p.D87N|CYB5D2_uc002fxl.3_Missense_Mutation_p.D87N	NM_144611	NP_653212	Q8WUJ1	NEUFC_HUMAN	cytochrome b5 domain containing 2	199					nervous system development	extracellular region	heme binding			large_intestine(2)|ovary(1)	3						TGTGAGCAGAGACTGGATTGG	0.572		NaN									OREG0024097	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.028581	0	13	42									
CAMTA2	23125	broad.mit.edu	37	17	4873702	4873702	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:4873702C>G	uc002gah.1	-	17	3046	c.2938G>C	c.(2938-2940)GAG>CAG	p.E980Q	SPAG7_uc002gae.2_5'Flank|SPAG7_uc002gaf.2_5'Flank|CAMTA2_uc010cku.1_Missense_Mutation_p.E1003Q|CAMTA2_uc002gag.1_Missense_Mutation_p.E979Q|CAMTA2_uc002gai.1_Missense_Mutation_p.E982Q|CAMTA2_uc010ckv.1_Missense_Mutation_p.E627Q	NM_015099	NP_055914	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	980					cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			ovary(1)	1						GACATGGTCTCACTGAGCCCC	0.607		NaN											0	0	0	0.010504	0	20	132									
TP53	7157	broad.mit.edu	37	17	7577547	7577547	+	Missense_Mutation	SNP	C	C	A	rs121912656		TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:7577547C>A	uc002gim.2	-	7	928	c.734G>T	c.(733-735)GGC>GTC	p.G245V	TP53_uc002gig.1_Missense_Mutation_p.G245V|TP53_uc002gih.2_Missense_Mutation_p.G245V|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.G113V|TP53_uc010cng.1_Missense_Mutation_p.G113V|TP53_uc002gii.1_Missense_Mutation_p.G113V|TP53_uc010cnh.1_Missense_Mutation_p.G245V|TP53_uc010cni.1_Missense_Mutation_p.G245V|TP53_uc002gij.2_Missense_Mutation_p.G245V|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.G152V|TP53_uc002gio.2_Missense_Mutation_p.G113V	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	245	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		G -> N (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> A (in sporadic cancers; somatic mutation).|G -> V (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> R (in sporadic cancers; somatic mutation).|G -> E (in a sporadic cancer; somatic mutation).|G -> D (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|G -> L (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G245S(274)|p.G245D(93)|p.G245V(50)|p.G245C(47)|p.G245R(10)|p.G245A(8)|p.0?(7)|p.G245G(3)|p.G245fs*2(3)|p.G245N(2)|p.G245H(1)|p.G245L(1)|p.G244fs*17(1)|p.G245F(1)|p.G245E(1)|p.C242_M246>L(1)|p.C238_M246delCNSSCMGGM(1)|p.G245del(1)|p.C242fs*98(1)|p.G245fs*22(1)|p.M243fs*18(1)|p.S241_G245delSCMGG(1)|p.G245fs*14(1)|p.G245fs*17(1)|p.G245fs*16(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCGGTTCATGCCGCCCATGCA	0.582		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			1	0	1.66031e-10	0.021523	1.83534e-10	21	62									
DNAH2	146754	broad.mit.edu	37	17	7643863	7643863	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:7643863G>A	uc002giu.1	+	9	1516	c.1502G>A	c.(1501-1503)CGC>CAC	p.R501H	DNAH2_uc002git.2_Missense_Mutation_p.R583H|DNAH2_uc010vuk.1_Missense_Mutation_p.R501H	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	501	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CTTGCCTCCCGCGAGGTGCGG	0.672		NaN											0	0	0	0.007413	0	14	107									
DNAH2	146754	broad.mit.edu	37	17	7673955	7673955	+	Silent	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:7673955C>G	uc002giu.1	+	25	4193	c.4179C>G	c.(4177-4179)CTC>CTG	p.L1393L		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	1393	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				ATCATCGGCTCAGGTCAGGGG	0.542		NaN											0	0	0	0.006122	0	17	104									
WDR16	146845	broad.mit.edu	37	17	9489122	9489122	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:9489122G>A	uc002gly.2	+	2	172	c.103G>A	c.(103-105)GAC>AAC	p.D35N	WDR16_uc002glz.2_Intron|WDR16_uc010coc.2_Missense_Mutation_p.D45N	NM_145054	NP_659491	Q8N1V2	WDR16_HUMAN	WD40-repeat protein upregulated in HCC isoform	35						cytoplasm|intracellular membrane-bounded organelle	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4						ATGCCATCCTGACCAGGAGCA	0.433		NaN											0	0	0	0.013726	0	31	140									
NCOR1	9611	broad.mit.edu	37	17	16040727	16040727	+	Splice_Site	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:16040727C>G	uc002gpo.2	-	14	1648	c.1408_splice	c.e14-1	p.S470_splice	NCOR1_uc002gpn.2_Splice_Site_p.S470_splice|NCOR1_uc002gpp.1_Splice_Site_p.S361_splice|NCOR1_uc002gpr.2_Splice_Site_p.S361_splice|NCOR1_uc002gps.1_Splice_Site_p.S479_splice|NCOR1_uc010coz.1_Splice_Site_p.S286_splice|NCOR1_uc010cpb.1_Splice_Site_p.S479_splice|NCOR1_uc010cpa.1_Splice_Site_p.S470_splice	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1						cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		CAGGAACACTCTGTAAGAAAT	0.294		NaN											0	0	0	0.009096	0	4	18									
ZNF287	57336	broad.mit.edu	37	17	16470799	16470799	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:16470799G>A	uc002gqi.2	-	2	700	c.247C>T	c.(247-249)CAC>TAC	p.H83Y		NM_020653	NP_065704	Q9HBT7	ZN287_HUMAN	zinc finger protein 287	76	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0				UCEC - Uterine corpus endometrioid carcinoma (92;0.083)		TCCTTTGAGTGAATCTCAGGT	0.493		NaN											0	0	0	0.024245	0	14	115									
SUPT6H	6830	broad.mit.edu	37	17	27028139	27028139	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:27028139C>T	uc002hby.2	+	36	5077	c.4987C>T	c.(4987-4989)CAG>TAG	p.Q1663*	SUPT6H_uc010crt.2_Nonsense_Mutation_p.Q1663*	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	1663					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					ACGGCAGCAGCAGCCAAAGTA	0.627		NaN											0	0	0	0.004482	0	7	76									
KRTAP4-8	728224	broad.mit.edu	37	17	39253806	39253806	+	Silent	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:39253806G>A	uc010wfo.1	-	1	570	c.531C>T	c.(529-531)CCC>CCT	p.P177P		NM_031960	NP_114166	Q9BYQ9	KRA48_HUMAN	keratin associated protein 4.8	177						keratin filament					0						CGCAGCACACGGGGCGGGGGC	0.542		NaN											0	0	0	0.00308	0	5	4									
KCNH4	23415	broad.mit.edu	37	17	40315336	40315336	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:40315336C>A	uc002hzb.2	-	14	2827	c.2494G>T	c.(2494-2496)GAG>TAG	p.E832*		NM_012285	NP_036417	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H,	832	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			large_intestine(1)	1		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		CCAGAGTCCTCAATGCCATCC	0.632		NaN											1	0	3.59834e-05	0.021553	3.77311e-05	6	25									
KCNH4	23415	broad.mit.edu	37	17	40315715	40315715	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:40315715G>A	uc002hzb.2	-	13	2719	c.2386C>T	c.(2386-2388)CAC>TAC	p.H796Y		NM_012285	NP_036417	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H,	796	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			large_intestine(1)	1		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		GGGGGGCCGTGAGGGGAGGCA	0.672		NaN											0	0	0	0.006214	0	6	20									
KCNH4	23415	broad.mit.edu	37	17	40323897	40323897	+	Silent	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:40323897G>A	uc002hzb.2	-	7	1437	c.1104C>T	c.(1102-1104)GTC>GTT	p.V368V		NM_012285	NP_036417	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H,	368	Helical; Name=Segment S5; (Potential).				regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			large_intestine(1)	1		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		GGAGCGCAAAGACCGACATGA	0.507		NaN											0	0	0	0.00308	0	6	62									
ABCC3	8714	broad.mit.edu	37	17	48753883	48753883	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:48753883C>G	uc002isl.2	+	23	3392	c.3312C>G	c.(3310-3312)ATC>ATG	p.I1104M	ABCC3_uc002isn.2_5'Flank	NM_003786	NP_003777	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C, member 3	1104	ABC transmembrane type-1 2.|Helical; Name=14; (By similarity).				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			skin(3)|central_nervous_system(1)	4			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	TTGTGGTCATCATGGCCAGCA	0.567		NaN											0	0	0	0.009535	0	26	122									
TEX14	56155	broad.mit.edu	37	17	56665024	56665024	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:56665024C>G	uc010dcz.1	-	17	2842	c.2724G>C	c.(2722-2724)ATG>ATC	p.M908I	TEX14_uc002iwr.1_Missense_Mutation_p.M902I|TEX14_uc002iws.1_Missense_Mutation_p.M902I|TEX14_uc010dda.1_Missense_Mutation_p.M682I	NM_198393	NP_938207	Q8IWB6	TEX14_HUMAN	testis expressed sequence 14 isoform a	908						cytoplasm	ATP binding|protein kinase activity			stomach(4)|lung(3)|breast(3)|ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)|pancreas(1)	17	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GTTCCACACTCATCCTGAATT	0.438		NaN									OREG0024616	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.009535	0	22	39									
PRR11	55771	broad.mit.edu	37	17	57275120	57275120	+	Silent	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:57275120G>A	uc002ixf.1	+	9	1063	c.984G>A	c.(982-984)GTG>GTA	p.V328V	PRR11_uc002ixg.1_RNA	NM_018304	NP_060774	Q96HE9	PRR11_HUMAN	proline rich 11	328										ovary(2)	2	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					TGACTCCAGTGATGACGCAGG	0.358		NaN											0	0	0	0.016522	0	21	130									
ACOX1	51	broad.mit.edu	37	17	73974647	73974647	+	Silent	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:73974647G>A	uc002jqf.2	-	2	527	c.237C>T	c.(235-237)ATC>ATT	p.I79I	ACOX1_uc010wsq.1_Silent_p.I41I|ACOX1_uc002jqe.2_Silent_p.I79I|ACOX1_uc010wsr.1_5'UTR|C17orf106_uc010dgs.1_5'Flank|CDK3_uc002jqg.3_5'Flank	NM_007292	NP_009223	Q15067	ACOX1_HUMAN	acyl-Coenzyme A oxidase 1 isoform b	79					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|prostaglandin metabolic process|very long-chain fatty acid metabolic process	peroxisomal matrix	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity|flavin adenine dinucleotide binding|protein N-terminus binding			ovary(1)	1						CAGGGTCAGCGATGCCAAACT	0.473		NaN											0	0	0	0.009535	0	26	132									
NOTUM	147111	broad.mit.edu	37	17	79911122	79911122	+	Silent	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:79911122C>T	uc010wvg.1	-	11	1478	c.1206G>A	c.(1204-1206)GTG>GTA	p.V402V		NM_178493	NP_848588	Q6P988	NOTUM_HUMAN	notum pectinacetylesterase homolog precursor	402						extracellular region	hydrolase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			ACGTCCCCTTCACCTGGACAT	0.617		NaN											0	0	0	0.009096	0	4	17									
KIAA1632	57724	broad.mit.edu	37	18	43510647	43510647	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr18:43510647A>G	uc002lbm.2	-	12	2507	c.2407T>C	c.(2407-2409)TAT>CAT	p.Y803H	KIAA1632_uc002lbo.1_Missense_Mutation_p.Y803H	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	803					autophagy						0						CTAACCTCATATATCTCCAGA	0.358		NaN											0	0	0	0.034045	0	23	29									
MAPK4	5596	broad.mit.edu	37	18	48241459	48241459	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr18:48241459C>T	uc002lev.2	+	3	1557	c.557C>T	c.(556-558)TCA>TTA	p.S186L	MAPK4_uc010xdm.1_5'UTR|MAPK4_uc010doz.2_Missense_Mutation_p.S186L	NM_002747	NP_002738	P31152	MK04_HUMAN	mitogen-activated protein kinase 4	186	Protein kinase.				cell cycle		ATP binding|MAP kinase activity			lung(4)|skin(2)	6		Colorectal(6;0.0297)		Colorectal(21;0.156)		GGTTATCTGTCAGAAGGGTTG	0.512		NaN											0	0	0	0.024334	0	21	117									
SERPINB11	89778	broad.mit.edu	37	18	61377511	61377511	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr18:61377511C>G	uc002ljk.3	+	2	146	c.84C>G	c.(82-84)ATC>ATG	p.I28M	SERPINB11_uc010xes.1_Translation_Start_Site|SERPINB11_uc010dqd.2_Translation_Start_Site|SERPINB11_uc002ljj.3_Translation_Start_Site|SERPINB11_uc010dqe.2_Translation_Start_Site|SERPINB11_uc010dqf.2_Missense_Mutation_p.I28M	NM_080475	NP_536723	Q96P15	SPB11_HUMAN	serpin peptidase inhibitor, clade B, member 11	28					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			breast(1)	1		Esophageal squamous(42;0.129)				GAGATAACATCTTCTTTTCTT	0.448		NaN											0	0	0	0.016522	0	21	27									
CDH19	28513	broad.mit.edu	37	18	64212042	64212043	+	Missense_Mutation	DNP	CC	CC	TT			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr18:64212042_64212043CC>TT	uc002lkc.1	-	6	1011_1012	c.873_874GG>AA	c.(871-876)ATGGAT>ATAAAT	p.291_292MD>IN	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_Missense_Mutation_p.291_292MD>IN|CDH19_uc002lkd.2_Missense_Mutation_p.291_292MD>IN	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	291_292	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				ATGCTGTAATCCATTTCTGCAT	0.351		NaN											0	0	0	0.004672	0	33	30									
CYB5A	1528	broad.mit.edu	37	18	71920849	71920849	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr18:71920849C>G	uc002lli.2	-	5	486	c.375G>C	c.(373-375)TTG>TTC	p.L125F	CYB5A_uc002llh.2_3'UTR	NM_148923	NP_683725	P00167	CYB5_HUMAN	cytochrome b-5 isoform 1	125	Helical; (Potential).				electron transport chain|water-soluble vitamin metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane	aldo-keto reductase (NADP) activity|cytochrome-c oxidase activity|enzyme binding|heme binding				0		Esophageal squamous(42;0.0749)|Prostate(75;0.157)|Melanoma(33;0.211)			Methoxyflurane(DB01028)	GGCGATACATCAAGGCGACGG	0.512		NaN											0	0	0	0.004672	0	3	55									
MIER2	54531	broad.mit.edu	37	19	325674	325674	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:325674C>T	uc002lok.1	-	7	625	c.616G>A	c.(616-618)GAC>AAC	p.D206N		NM_017550	NP_060020	Q8N344	MIER2_HUMAN	mesoderm induction early response 1, family	206	ELM2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0		all_cancers(10;1.05e-30)|all_epithelial(18;3.04e-19)|Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;2.49e-05)|all_lung(49;4.36e-05)|Breast(49;0.000304)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTGCTGAGGTCAGCTTGGAAC	0.607		NaN											0	0	0	0.012319	0	15	73									
SAFB2	9667	broad.mit.edu	37	19	5613501	5613501	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:5613501G>T	uc002mcd.2	-	5	793	c.581C>A	c.(580-582)TCA>TAA	p.S194*	SAFB2_uc010xio.1_Nonsense_Mutation_p.S194*|SAFB2_uc010xip.1_RNA	NM_014649	NP_055464	Q14151	SAFB2_HUMAN	scaffold attachment factor B2	194					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding				0				UCEC - Uterine corpus endometrioid carcinoma (162;0.000228)		GTTCAACGATGAAGTTTCCAA	0.423		NaN											1	0	7.41877e-09	0.012319	8.0792e-09	17	59									
LRRC8E	80131	broad.mit.edu	37	19	7965381	7965381	+	Silent	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:7965381C>G	uc002mir.2	+	3	2075	c.1974C>G	c.(1972-1974)CTC>CTG	p.L658L		NM_025061	NP_079337	Q6NSJ5	LRC8E_HUMAN	leucine rich repeat containing 8 family, member	658	LRR 7.					integral to membrane				lung(1)|pancreas(1)	2						TGGAGCAGCTCTACCTCAGCT	0.632		NaN											0	0	0	0.02938	0	7	24									
MUC16	94025	broad.mit.edu	37	19	9086461	9086461	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:9086461G>T	uc002mkp.2	-	1	5558	c.5354C>A	c.(5353-5355)TCA>TAA	p.S1785*		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1785	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGTCCTTGCTGAAGACTTGGA	0.468		NaN											1	0	3.57192e-18	0.006122	4.03353e-18	15	55									
MUC16	94025	broad.mit.edu	37	19	9088659	9088659	+	Silent	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:9088659C>T	uc002mkp.2	-	1	3360	c.3156G>A	c.(3154-3156)TTG>TTA	p.L1052L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1052	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGCTTGTGTCCAATCTTCCTT	0.478		NaN											0	0	0	0.008871	0	19	65									
TNPO2	30000	broad.mit.edu	37	19	12829859	12829859	+	Silent	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:12829859G>A	uc002muo.2	-	4	494	c.309C>T	c.(307-309)CTC>CTT	p.L103L	TNPO2_uc002mup.2_Silent_p.L195L|TNPO2_uc002muq.2_Silent_p.L103L|TNPO2_uc002mur.2_Silent_p.L103L	NM_001136196	NP_001129668	O14787	TNPO2_HUMAN	transportin 2 (importin 3, karyopherin beta 2b)	103					intracellular protein transport	cytoplasm|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			ovary(1)	1						TGGCTCGGATGAGCGAGGAGG	0.463		NaN											0	0	0	0.021022	0	31	131									
RFX1	5989	broad.mit.edu	37	19	14079426	14079426	+	Silent	SNP	C	C	T	rs150138140		TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:14079426C>T	uc002mxv.2	-	12	1955	c.1683G>A	c.(1681-1683)ACG>ACA	p.T561T		NM_002918	NP_002909	P22670	RFX1_HUMAN	regulatory factor X1	561					immune response	nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			lung(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(19;6.67e-23)			CCGACAGCCCCGTGCTCGGCT	0.662		NaN											0	0	0	0.034045	0	21	64									
CYP4F12	66002	broad.mit.edu	37	19	15794528	15794528	+	Silent	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:15794528C>G	uc002nbl.2	+	7	934	c.873C>G	c.(871-873)GCC>GCG	p.A291A		NM_023944	NP_076433			cytochrome P450, family 4, subfamily F,											skin(3)|ovary(2)|central_nervous_system(2)	7	Acute lymphoblastic leukemia(2;0.0367)					AAGACAAAGCCAAGTCCAAGA	0.488		NaN											0	0	0	0.021523	0	21	85									
RAB3A	5864	broad.mit.edu	37	19	18311177	18311177	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:18311177C>A	uc002nie.2	-	3	476	c.307G>T	c.(307-309)GAC>TAC	p.D103Y		NM_002866	NP_002857	P20336	RAB3A_HUMAN	RAB3A, member RAS oncogene family	103					glutamate secretion|protein transport|small GTPase mediated signal transduction	clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|plasma membrane|synaptic vesicle	GTP binding|GTPase activity				0						TTGGTGATGTCATACATGAGG	0.443		NaN											1	0	3.5997e-14	0.014323	4.01547e-14	18	96									
ZNF100	163227	broad.mit.edu	37	19	21909652	21909652	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:21909652C>G	uc002nqi.2	-	5	1661	c.1462G>C	c.(1462-1464)GAG>CAG	p.E488Q	ZNF100_uc002nqh.2_Missense_Mutation_p.E424Q	NM_173531	NP_775802	Q8IYN0	ZN100_HUMAN	zinc finger protein 100	488	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CCACATTCCTCACATTTGTAG	0.398		NaN											0	0	0	0.028581	0	11	85									
WTIP	126374	broad.mit.edu	37	19	34983976	34983976	+	Silent	SNP	G	G	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:34983976G>C	uc002nvm.2	+	3	804	c.804G>C	c.(802-804)GTG>GTC	p.V268V		NM_001080436	NP_001073905			Wilms tumor 1 interacting protein												0	all_lung(56;5.94e-07)|Lung NSC(56;9.35e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)			TCTACAACGTGGGTGAGAAAG	0.627		NaN											0	0	0	0.027356	0	23	134									
ZNF382	84911	broad.mit.edu	37	19	37117266	37117266	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:37117266C>A	uc002oek.2	+	5	580	c.467C>A	c.(466-468)CCC>CAC	p.P156H	ZNF382_uc010efa.2_Missense_Mutation_p.P107H|ZNF382_uc010efb.2_Missense_Mutation_p.P155H|ZNF382_uc002oel.2_Missense_Mutation_p.P155H	NM_032825	NP_116214	Q96SR6	ZN382_HUMAN	zinc finger protein 382	156	Represses transcription (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			AATATAAGCCCCATAAAAGAG	0.343		NaN											1	0	3.62473e-10	0.012319	3.99482e-10	15	140									
SIPA1L3	23094	broad.mit.edu	37	19	38673330	38673330	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:38673330G>C	uc002ohk.2	+	16	4889	c.4380G>C	c.(4378-4380)AAG>AAC	p.K1460N		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	1460					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CAGGGTGGAAGAGAACGGAGG	0.642		NaN											0	0	0	0.010504	0	17	61									
PSG1	5669	broad.mit.edu	37	19	43382064	43382064	+	Splice_Site	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:43382064C>T	uc002ovb.2	-	2	568	c.430_splice	c.e2+1	p.L144_splice	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Splice_Site_p.L144_splice|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG1_uc002oun.2_Splice_Site|PSG1_uc002our.1_Splice_Site_p.L144_splice|PSG1_uc010eio.1_Splice_Site_p.L144_splice|PSG1_uc002oux.1_Intron|PSG1_uc002ouy.1_Splice_Site_p.L144_splice|PSG1_uc002ouz.1_Splice_Site_p.L144_splice|PSG1_uc002ova.1_Splice_Site_p.P144_splice|PSG1_uc002ovc.2_Splice_Site_p.P144_splice|PSG1_uc002ovd.1_Splice_Site_p.L144_splice	NM_006905	NP_008836	P11464	PSG1_HUMAN	pregnancy specific beta-1-glycoprotein 1						female pregnancy	extracellular region				ovary(2)	2		Prostate(69;0.00682)				GAATCACTTACGGTGTAAGGT	0.517		NaN											0	0	0	0.01441	0	127	204									
PSG2	5670	broad.mit.edu	37	19	43575870	43575870	+	Silent	SNP	A	A	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:43575870A>G	uc002ovr.2	-	4	1039	c.946T>C	c.(946-948)TTG>CTG	p.L316L	PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG2_uc002ovq.3_Silent_p.L316L|PSG2_uc010eiq.1_Silent_p.L316L|PSG2_uc002ovs.3_Silent_p.L316L|PSG2_uc002ovt.3_Silent_p.L316L	NM_031246	NP_112536	P11465	PSG2_HUMAN	pregnancy specific beta-1-glycoprotein 2	316	Ig-like C2-type 2.				cell migration|female pregnancy	extracellular region					0		Prostate(69;0.00682)				TTGACTGTCAACGATGTGGAG	0.458		NaN											0	0	0	0.036044	0	37	243									
XRCC1	7515	broad.mit.edu	37	19	44050093	44050093	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:44050093C>T	uc002owt.2	-	14	1618	c.1498G>A	c.(1498-1500)GAA>AAA	p.E500K	XRCC1_uc010xwp.1_Missense_Mutation_p.E469K	NM_006297	NP_006288	P18887	XRCC1_HUMAN	X-ray repair cross complementing protein 1	500					base-excision repair|single strand break repair	nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(2)|large_intestine(1)|prostate(1)|breast(1)	7		Prostate(69;0.0153)				AGTCTGTGTTCCTTCTGCTCT	0.627		NaN						Other_BER_factors					0	0	0	0.014758	0	4	35									
XRCC1	7515	broad.mit.edu	37	19	44050097	44050097	+	Silent	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:44050097C>T	uc002owt.2	-	14	1614	c.1494G>A	c.(1492-1494)CAG>CAA	p.Q498Q	XRCC1_uc010xwp.1_Silent_p.Q467Q	NM_006297	NP_006288	P18887	XRCC1_HUMAN	X-ray repair cross complementing protein 1	498					base-excision repair|single strand break repair	nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(2)|large_intestine(1)|prostate(1)|breast(1)	7		Prostate(69;0.0153)				TGTGTTCCTTCTGCTCTGCCA	0.632		NaN						Other_BER_factors					0	0	0	0.021553	0	5	34									
XRCC1	7515	broad.mit.edu	37	19	44051059	44051059	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:44051059C>T	uc002owt.2	-	11	1390	c.1270G>A	c.(1270-1272)GAA>AAA	p.E424K	XRCC1_uc010xwp.1_Missense_Mutation_p.E393K	NM_006297	NP_006288	P18887	XRCC1_HUMAN	X-ray repair cross complementing protein 1	424					base-excision repair|single strand break repair	nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(2)|large_intestine(1)|prostate(1)|breast(1)	7		Prostate(69;0.0153)				TTGGGGGCTTCATCTCCGCTG	0.607		NaN						Other_BER_factors					0	0	0	0.021523	0	22	97									
MYPOP	339344	broad.mit.edu	37	19	46393972	46393972	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:46393972G>A	uc002pdt.2	-	3	1196	c.1109C>T	c.(1108-1110)CCA>CTA	p.P370L		NM_001012643	NP_001012661	Q86VE0	MYPOP_HUMAN	Myb protein P42POP	370	Pro-rich.					nucleus	DNA binding				0						GAGCGGGGCTGGGGGGGGCCG	0.662		NaN											0	0	0	0.004672	0	3	9									
TRPM4	54795	broad.mit.edu	37	19	49674990	49674990	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:49674990C>G	uc002pmw.2	+	8	1086	c.1014C>G	c.(1012-1014)TTC>TTG	p.F338L	TRPM4_uc010emu.2_Missense_Mutation_p.F338L|TRPM4_uc010yak.1_5'UTR|TRPM4_uc002pmx.2_Missense_Mutation_p.F164L|TRPM4_uc010emv.2_Missense_Mutation_p.F223L|TRPM4_uc010yal.1_Missense_Mutation_p.F55L	NM_017636	NP_060106	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel,	338	Cytoplasmic (Potential).				dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			ovary(1)|central_nervous_system(1)	2		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		TCAGGCGTTTCTTTCCCAAAG	0.463		NaN											0	0	0	0.007413	0	17	24									
ETFB	2109	broad.mit.edu	37	19	51856530	51856530	+	Silent	SNP	G	G	A	rs147509776		TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:51856530G>A	uc002pwh.2	-	3	323	c.231C>T	c.(229-231)ACC>ACT	p.T77T	ETFB_uc002pwg.2_Silent_p.T168T	NM_001985	NP_001976	P38117	ETFB_HUMAN	electron-transfer-flavoprotein, beta polypeptide	77					respiratory electron transport chain|transport	mitochondrial matrix	electron carrier activity				0		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000226)|OV - Ovarian serous cystadenocarcinoma(262;0.00661)		TGGCCAGGGCGGTACGAATCG	0.512		NaN											0	0	0	0.016723	0	10	93									
NKG7	4818	broad.mit.edu	37	19	51875508	51875508	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:51875508C>T	uc002pwj.2	-	2	382	c.211G>A	c.(211-213)GTG>ATG	p.V71M	NKG7_uc002pwk.2_Intron	NM_005601	NP_005592	Q16617	NKG7_HUMAN	natural killer cell group 7 sequence	71	Helical; (Potential).					integral to plasma membrane				central_nervous_system(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000211)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		CTCACGGACACCAGGGCCCAC	0.617		NaN											0	0	0	0.01441	0	47	117									
ZNF845	91664	broad.mit.edu	37	19	53854452	53854452	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:53854452C>G	uc010ydv.1	+	4	641	c.524C>G	c.(523-525)TCA>TGA	p.S175*	ZNF845_uc010ydw.1_Nonsense_Mutation_p.S175*	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	175					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCGTTGGTTTCAACATCCCAA	0.388		NaN											0	0	0	0.0333	0	17	55									
ZIK1	284307	broad.mit.edu	37	19	58101751	58101751	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:58101751G>A	uc002qpg.2	+	4	669	c.572G>A	c.(571-573)GGC>GAC	p.G191D	ZNF547_uc002qpm.3_Intron|ZIK1_uc002qph.2_Missense_Mutation_p.G136D|ZIK1_uc002qpi.2_Missense_Mutation_p.G178D|ZIK1_uc002qpj.2_Missense_Mutation_p.G88D	NM_001010879	NP_001010879	Q3SY52	ZIK1_HUMAN	zinc finger protein interacting with K protein	191					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		TTTCCTGGAGGCAAGAAACCC	0.498		NaN											0	0	0	0.011902	0	39	57									
PDIA6	10130	broad.mit.edu	37	2	10952816	10952816	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr2:10952816G>A	uc002rau.2	-	1	145	c.7C>T	c.(7-9)CTC>TTC	p.L3F	PDIA6_uc010yjg.1_5'UTR|PDIA6_uc002rav.2_Intron|PDIA6_uc010yjh.1_Intron|PDIA6_uc002raw.2_Intron	NM_005742	NP_005733	Q15084	PDIA6_HUMAN	protein disulfide isomerase A6 precursor	3					cell redox homeostasis|glycerol ether metabolic process|protein folding	endoplasmic reticulum lumen|ER-Golgi intermediate compartment|melanosome|plasma membrane	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.149)|OV - Ovarian serous cystadenocarcinoma(76;0.15)		AGCACCAGGAGAGCCATGCCG	0.687		NaN											0	0	0	0.014758	0	3	11									
OTOF	9381	broad.mit.edu	37	2	26706500	26706500	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr2:26706500C>T	uc002rhk.2	-	13	1349	c.1222G>A	c.(1222-1224)GAG>AAG	p.E408K		NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	408	Cytoplasmic (Potential).|C2 2.				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGCACCCCCTCGGGGAGCAGC	0.602		NaN											0	0	0	0.004482	0	7	23									
VIT	5212	broad.mit.edu	37	2	36982074	36982074	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr2:36982074G>C	uc002rpl.2	+	5	507	c.286G>C	c.(286-288)GAT>CAT	p.D96H	VIT_uc002rpk.2_Missense_Mutation_p.D89H|VIT_uc010ynf.1_Missense_Mutation_p.D89H|VIT_uc002rpm.2_Missense_Mutation_p.D89H|VIT_uc010ezv.2_Missense_Mutation_p.D89H|VIT_uc010ezw.2_Missense_Mutation_p.D89H	NM_053276	NP_444506	Q6UXI7	VITRN_HUMAN	vitrin	96	LCCL.					proteinaceous extracellular matrix				ovary(1)|pancreas(1)	2		all_hematologic(82;0.248)				TGGTGTGCTTGATAATTCAGG	0.393		NaN											0	0	0	0.036044	0	34	40									
CALM2	805	broad.mit.edu	37	2	47389450	47389450	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr2:47389450C>G	uc002rvt.2	-	4	418	c.260G>C	c.(259-261)AGA>ACA	p.R87T	C2orf61_uc010fbd.2_Intron|CALM2_uc010fbe.2_Intron	NM_001743	NP_001734	P62158	CALM_HUMAN	calmodulin 2	87	EF-hand 3.				activation of phospholipase C activity|G-protein coupled receptor protein signaling pathway|glucose metabolic process|glycogen catabolic process|muscle contraction|negative regulation of ryanodine-sensitive calcium-release channel activity|nerve growth factor receptor signaling pathway|nitric oxide metabolic process|platelet activation|platelet degranulation|positive regulation of ryanodine-sensitive calcium-release channel activity|regulation of cytokinesis|regulation of nitric-oxide synthase activity|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to calcium ion|synaptic transmission	centrosome|cytosol|extracellular region|nucleoplasm|plasma membrane|spindle microtubule|spindle pole	calcium ion binding|N-terminal myristoylation domain binding|phospholipase binding|protein domain specific binding|thioesterase binding|titin binding	p.0?(2)			0		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)		Aprindine(DB01429)|Bepridil(DB01244)|Dibucaine(DB00527)|Felodipine(DB01023)|Flunarizine(DB04841)|Fluphenazine(DB00623)|Isoflurane(DB00753)|Loperamide(DB00836)|Miconazole(DB01110)|Perphenazine(DB00850)|Phenoxybenzamine(DB00925)|Pimozide(DB01100)|Promethazine(DB01069)	GAATGCTTCTCTAATTTCTTC	0.368		NaN											0	0	0	0.004482	0	6	43									
FAM176A	84141	broad.mit.edu	37	2	75720637	75720637	+	Missense_Mutation	SNP	C	C	G	rs150035696	byFrequency	TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr2:75720637C>G	uc002sni.2	-	4	662	c.184G>C	c.(184-186)GAC>CAC	p.D62H	FAM176A_uc002snj.1_Missense_Mutation_p.D49H|FAM176A_uc002snk.1_Missense_Mutation_p.D62H	NM_001135032	NP_001128504	Q9H8M9	F176A_HUMAN	family with sequence similarity 176, member A	62					apoptosis|autophagy	endoplasmic reticulum membrane|integral to membrane|lysosomal membrane|plasma membrane					0						CGCCTGCAGTCTGTGTGGCAA	0.587		NaN											0	0	0	0.010729	0	12	54									
SEMA4C	54910	broad.mit.edu	37	2	97531659	97531659	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr2:97531659C>A	uc002sxh.3	-	4	426	c.266G>T	c.(265-267)TGG>TTG	p.W89L	SEMA4C_uc002sxf.3_5'Flank|SEMA4C_uc002sxe.2_5'Flank|SEMA4C_uc002sxg.3_Missense_Mutation_p.W142L	NM_017789	NP_060259	Q9C0C4	SEM4C_HUMAN	semaphorin 4C precursor	89	Extracellular (Potential).|Dominant negative effect on myogenic differentiation (By similarity).|Sema.				muscle cell differentiation|nervous system development|positive regulation of stress-activated MAPK cascade	cell junction|integral to membrane|postsynaptic density|postsynaptic membrane|synaptic vesicle membrane	receptor activity			skin(2)	2						GGGGGCCTCCCAGGAGATCTG	0.597		NaN											1	0	7.93312e-07	0.020292	8.41461e-07	11	113									
TMEM87B	84910	broad.mit.edu	37	2	112838657	112838657	+	Missense_Mutation	SNP	C	C	T	rs151250123		TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr2:112838657C>T	uc002thm.2	+	7	985	c.616C>T	c.(616-618)CAT>TAT	p.H206Y	TMEM87B_uc010fkg.2_Missense_Mutation_p.H189Y|TMEM87B_uc010fkh.2_3'UTR	NM_032824	NP_116213	Q96K49	TM87B_HUMAN	transmembrane protein 87B precursor	206						integral to membrane					0						GATTGGGCCTCATGGATATAT	0.333		NaN											0	0	0	0.036044	0	25	46									
TMEM87B	84910	broad.mit.edu	37	2	112838676	112838676	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr2:112838676C>G	uc002thm.2	+	7	1004	c.635C>G	c.(634-636)TCA>TGA	p.S212*	TMEM87B_uc010fkg.2_Nonsense_Mutation_p.S195*|TMEM87B_uc010fkh.2_3'UTR	NM_032824	NP_116213	Q96K49	TM87B_HUMAN	transmembrane protein 87B precursor	212						integral to membrane					0						ATCTCTGCATCAGATTGGCCC	0.328		NaN											0	0	0	0.011902	0	27	44									
TMEM87B	84910	broad.mit.edu	37	2	112839041	112839041	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr2:112839041G>C	uc002thm.2	+	8	1153	c.784G>C	c.(784-786)GAA>CAA	p.E262Q	TMEM87B_uc010fkg.2_Missense_Mutation_p.E245Q|TMEM87B_uc010fkh.2_3'UTR	NM_032824	NP_116213	Q96K49	TM87B_HUMAN	transmembrane protein 87B precursor	262	Helical; (Potential).					integral to membrane					0						GGGAATGCTTGAAAAAGCAGT	0.358		NaN											0	0	0	0.01441	0	44	77									
SCTR	6344	broad.mit.edu	37	2	120231035	120231035	+	Missense_Mutation	SNP	C	C	G	rs142755533		TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr2:120231035C>G	uc002tma.2	-	4	625	c.399G>C	c.(397-399)GAG>GAC	p.E133D	SCTR_uc002tlz.2_5'UTR	NM_002980	NP_002971	P47872	SCTR_HUMAN	secretin receptor precursor	133	Extracellular (Potential).				digestion|excretion	integral to plasma membrane	secretin receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3					Secretin(DB00021)	TTACCCGCTTCTCGTTGGAAG	0.592		NaN											0	0	0	0.016723	0	12	28									
SMPD4	55627	broad.mit.edu	37	2	130911366	130911366	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr2:130911366G>C	uc002tqq.1	-	17	2439	c.1919C>G	c.(1918-1920)GCC>GGC	p.A640G	SMPD4_uc002tqo.1_Missense_Mutation_p.A172G|SMPD4_uc002tqp.1_Missense_Mutation_p.A379G|SMPD4_uc010yzy.1_Missense_Mutation_p.A389G|SMPD4_uc010yzz.1_Missense_Mutation_p.A304G|SMPD4_uc002tqr.1_Missense_Mutation_p.A611G|SMPD4_uc002tqs.1_Missense_Mutation_p.A508G|SMPD4_uc002tqt.1_Missense_Mutation_p.A489G|SMPD4_uc010zaa.1_Missense_Mutation_p.A498G|SMPD4_uc010zab.1_Missense_Mutation_p.A538G|SMPD4_uc010zac.1_Missense_Mutation_p.A381G|SMPD4_uc010zad.1_Missense_Mutation_p.A276G	NM_017951	NP_060421	Q9NXE4	NSMA3_HUMAN	sphingomyelin phosphodiesterase 4 isoform 2	601					sphingomyelin catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|trans-Golgi network	metal ion binding|protein binding|sphingomyelin phosphodiesterase activity|sphingomyelin phosphodiesterase D activity				0	Colorectal(110;0.1)				Phosphatidylserine(DB00144)	CAGGTCGTTGGCTGTGTAGGA	0.592		NaN											0	0	0	0.01441	0	196	129									
LCT	3938	broad.mit.edu	37	2	136566130	136566130	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr2:136566130C>T	uc002tuu.1	-	8	3798	c.3787G>A	c.(3787-3789)GAG>AAG	p.E1263K		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	1263	3.|Extracellular (Potential).|4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		TCACCATACTCTTCCTTGATC	0.537		NaN											0	0	0	0.01441	0	85	76									
PKP4	8502	broad.mit.edu	37	2	159481626	159481626	+	Silent	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr2:159481626C>T	uc002tzv.2	+	7	1100	c.840C>T	c.(838-840)GCC>GCT	p.A280A	PKP4_uc002tzt.1_Silent_p.A132A|PKP4_uc002tzu.2_Silent_p.A280A|PKP4_uc002tzw.2_Silent_p.A280A|PKP4_uc002tzx.2_5'UTR|PKP4_uc002tzy.1_5'UTR|PKP4_uc002tzz.1_Silent_p.A278A|PKP4_uc002uaa.2_Silent_p.A132A	NM_003628	NP_003619	Q99569	PKP4_HUMAN	plakophilin 4 isoform a	280					cell adhesion	desmosome	protein binding			ovary(5)|skin(2)	7						AGAGACCCGCCTCCCCAACAG	0.612		NaN								HNSCC(62;0.18)			0	0	0	0.008291	0	10	48									
HOXD3	3232	broad.mit.edu	37	2	177034235	177034235	+	Silent	SNP	C	C	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr2:177034235C>A	uc002ukt.1	+	2	569	c.393C>A	c.(391-393)CCC>CCA	p.P131P		NM_006898	NP_008829	P31249	HXD3_HUMAN	homeobox D3	131					anterior/posterior pattern formation|cartilage development|cell-matrix adhesion|embryonic skeletal system morphogenesis|Notch signaling pathway|positive regulation of gene expression|positive regulation of neuron differentiation|thyroid gland development		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.247)		catcttcacccACCAATCCTG	0.463		NaN											1	0	3.86212e-05	0.008291	4.0267e-05	10	61									
PDE11A	50940	broad.mit.edu	37	2	178936390	178936390	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr2:178936390C>G	uc002ulq.2	-	1	1093	c.775G>C	c.(775-777)GAT>CAT	p.D259H	PDE11A_uc002ulr.2_Intron|PDE11A_uc002ult.1_Intron	NM_016953	NP_058649	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A isoform 4	259	GAF 1.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(3)|large_intestine(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			GCATGCACATCAAAGAATTTG	0.532		NaN							Primary_Pigmented_Nodular_Adrenocortical_Disease_Familial				0	0	0	0.020292	0	14	32									
TTN	7273	broad.mit.edu	37	2	179587610	179587610	+	Missense_Mutation	SNP	G	G	A	rs72648966		TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr2:179587610G>A	uc010zfg.1	-	73	18508	c.18284C>T	c.(18283-18285)TCG>TTG	p.S6095L	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.S2756L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7022							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAAAGAAACCGAATCTCCAAC	0.438		NaN											0	0	0	0.02938	0	5	24									
TTN	7273	broad.mit.edu	37	2	179605206	179605206	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr2:179605206G>C	uc010zfh.1	-	46	12465	c.12241C>G	c.(12241-12243)CTT>GTT	p.L4081V	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Missense_Mutation_p.L4014V|TTN_uc010zfj.1_Missense_Mutation_p.L3889V|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCTTTTGAAGAGTCACTCTT	0.463		NaN											0	0	0	0.004482	0	7	37									
BARD1	580	broad.mit.edu	37	2	215609878	215609878	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr2:215609878G>C	uc002veu.2	-	9	1951	c.1816C>G	c.(1816-1818)CAT>GAT	p.H606D	BARD1_uc010zjm.1_Missense_Mutation_p.H462D	NM_000465	NP_000456	Q99728	BARD1_HUMAN	BRCA1 associated RING domain 1	606	BRCT 1.				cell cycle arrest|DNA repair|negative regulation of apoptosis|negative regulation of mRNA 3'-end processing|negative regulation of protein export from nucleus|positive regulation of apoptosis|positive regulation of protein catabolic process|protein K6-linked ubiquitination|regulation of phosphorylation|tissue homeostasis	BRCA1-A complex|BRCA1-BARD1 complex|cytoplasm	kinase binding|protein heterodimerization activity|protein homodimerization activity|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)	2		Renal(323;0.0243)		Epithelial(149;3.2e-06)|all cancers(144;0.000461)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		ACAACAACATGAGTTACTAAA	0.338		NaN							Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				0	0	0	0.020292	0	11	36									
TNS1	7145	broad.mit.edu	37	2	218683208	218683208	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr2:218683208G>C	uc002vgt.2	-	24	3933	c.3535C>G	c.(3535-3537)CAG>GAG	p.Q1179E	TNS1_uc002vgr.2_Missense_Mutation_p.Q1166E|TNS1_uc002vgs.2_Missense_Mutation_p.Q1158E|TNS1_uc010zjv.1_Missense_Mutation_p.Q1158E	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	1179						cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		TGGCGCGCCTGAGGGCTCCCA	0.637		NaN											0	0	0	0.016723	0	11	79									
PCSK2	5126	broad.mit.edu	37	20	17445975	17445975	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr20:17445975G>A	uc002wpm.2	+	11	1527	c.1207G>A	c.(1207-1209)GGT>AGT	p.G403S	PCSK2_uc002wpl.2_Missense_Mutation_p.G384S|PCSK2_uc010zrm.1_Missense_Mutation_p.G368S|PCSK2_uc002wpn.2_Missense_Mutation_p.G57S	NM_002594	NP_002585	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	403	Catalytic.				enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			ovary(3)|central_nervous_system(2)|large_intestine(1)|pancreas(1)	7					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ATCCAGCCTGGGTCTGACCTG	0.562		NaN											0	0	0	0.016522	0	21	42									
CST1	1469	broad.mit.edu	37	20	23731323	23731323	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr20:23731323C>G	uc002wtp.2	-	1	252	c.181G>C	c.(181-183)GAT>CAT	p.D61H		NM_001898	NP_001889	P01037	CYTN_HUMAN	cystatin SN precursor	61						extracellular region	cysteine-type endopeptidase inhibitor activity			ovary(1)	1	Lung NSC(19;0.0676)|all_lung(19;0.148)					TAGTAGTCATCTTTGGTGGCC	0.567		NaN											0	0	0	0.033182	0	35	65									
PTPRT	11122	broad.mit.edu	37	20	40748574	40748574	+	Splice_Site	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr20:40748574C>T	uc002xkg.2	-	20	3068	c.2884_splice	c.e20+1	p.G962_splice	PTPRT_uc010ggj.2_Splice_Site_p.G981_splice|PTPRT_uc010ggi.2_Splice_Site_p.G165_splice	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T						homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				AGGGCACTTACCTTGAGTCGC	0.512		NaN											0	0	0	0.01441	0	49	104									
SERINC3	10955	broad.mit.edu	37	20	43129871	43129871	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr20:43129871C>T	uc002xme.2	-	9	1260	c.1126G>A	c.(1126-1128)GAT>AAT	p.D376N	SERINC3_uc002xmf.1_Missense_Mutation_p.D376N|SERINC3_uc010ggs.1_Missense_Mutation_p.D369N|SERINC3_uc010zwp.1_Missense_Mutation_p.D321N	NM_198941	NP_945179	Q13530	SERC3_HUMAN	tumor differentially expressed protein 1	376	Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			skin(3)	3		Myeloproliferative disorder(115;0.0122)	Colorectal(3;0.000291)|COAD - Colon adenocarcinoma(18;0.00189)			GTAGTTGTATCACCAAGGATG	0.507		NaN											0	0	0	0.017118	0	25	158									
ACOT8	10005	broad.mit.edu	37	20	44477114	44477114	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr20:44477114C>G	uc002xqa.1	-	3	544	c.463G>C	c.(463-465)GAG>CAG	p.E155Q	ACOT8_uc010zxe.1_Missense_Mutation_p.E155Q|ACOT8_uc002xqc.1_Missense_Mutation_p.E102Q|ACOT8_uc010zxf.1_Intron	NM_005469	NP_005460	O14734	ACOT8_HUMAN	peroxisomal acyl-CoA thioesterase 1 isoform a	155					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase|interspecies interaction between organisms|peroxisome organization	peroxisomal matrix	acetyl-CoA hydrolase activity|acyl-CoA thioesterase activity|carboxylesterase activity|choloyl-CoA hydrolase activity|protein binding			skin(1)	1		Myeloproliferative disorder(115;0.0122)				ATGAGGGTCTCACAGTCAAGC	0.453		NaN											0	0	0	0.01441	0	48	312									
RAE1	8480	broad.mit.edu	37	20	55948726	55948726	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr20:55948726G>C	uc002xyg.2	+	10	1098	c.757G>C	c.(757-759)GAT>CAT	p.D253H	RAE1_uc010gis.1_Missense_Mutation_p.D206H|RAE1_uc010git.1_Missense_Mutation_p.D253H|RAE1_uc002xyh.2_Missense_Mutation_p.D253H|RAE1_uc002xyi.2_Missense_Mutation_p.D253H	NM_003610	NP_003601	P78406	RAE1L_HUMAN	RAE1 (RNA export 1, S.pombe) homolog	253					carbohydrate metabolic process|glucose transport|mRNA export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|cytoskeleton|nuclear outer membrane|nuclear pore	microtubule binding|RNA binding				0	Lung NSC(12;0.00263)|all_lung(29;0.00828)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;3.7e-14)|Epithelial(14;1.07e-09)|all cancers(14;1.11e-08)			CAGCGCCAAAGATAACTTCAC	0.418		NaN											0	0	0	0.01441	0	65	151									
DONSON	29980	broad.mit.edu	37	21	34951767	34951767	+	Silent	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr21:34951767C>T	uc002ysk.2	-	9	1519	c.1452G>A	c.(1450-1452)CTG>CTA	p.L484L	DONSON_uc002ysi.1_Silent_p.L244L|DONSON_uc002ysj.2_Silent_p.L117L|DONSON_uc002ysl.2_Silent_p.L117L|DONSON_uc010gme.2_Silent_p.L457L|DONSON_uc002ysm.2_Silent_p.L484L	NM_017613	NP_060083	Q9NYP3	DONS_HUMAN	downstream neighbor of SON	484					multicellular organismal development	nucleus				ovary(1)|central_nervous_system(1)	2						GCAGCATGGTCAGTGAATGCA	0.443		NaN											0	0	0	0.030593	0	23	134									
PRDM15	63977	broad.mit.edu	37	21	43222983	43222983	+	Silent	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr21:43222983C>G	uc002yzq.1	-	30	4041	c.3930G>C	c.(3928-3930)GCG>GCC	p.A1310A	PRDM15_uc002yzo.2_Silent_p.A981A|PRDM15_uc002yzp.2_Silent_p.A1001A|PRDM15_uc002yzr.1_Silent_p.A1001A	NM_022115	NP_071398	P57071	PRD15_HUMAN	PR domain containing 15 isoform 1	1310					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CCGGAGCACCCGCCTCCTCTT	0.577		NaN											0	0	0	0.01441	0	47	294									
UMODL1	89766	broad.mit.edu	37	21	43504216	43504216	+	Silent	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr21:43504216C>T	uc002zaf.1	+	3	342	c.342C>T	c.(340-342)TTC>TTT	p.F114F	UMODL1_uc002zad.1_Silent_p.F42F|UMODL1_uc002zae.1_Silent_p.F42F|UMODL1_uc002zag.1_Silent_p.F114F|UMODL1_uc010gow.1_5'Flank|UMODL1_uc002zai.1_5'Flank|UMODL1_uc010gox.1_5'Flank|UMODL1_uc010goy.1_5'Flank|UMODL1_uc002zaj.1_5'Flank|UMODL1_uc010goz.1_5'Flank	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	114	Extracellular (Potential).|WAP.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						CCGGGCAGTTCACGTCAAGAC	0.562		NaN											0	0	0	0.01441	0	75	200									
PKNOX1	5316	broad.mit.edu	37	21	44427655	44427655	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr21:44427655G>C	uc002zcq.1	+	3	294	c.106G>C	c.(106-108)GAT>CAT	p.D36H	PKNOX1_uc002zcp.1_Missense_Mutation_p.D36H|PKNOX1_uc011aex.1_5'UTR|PKNOX1_uc002zcr.2_Missense_Mutation_p.D36H	NM_004571	NP_004562	P55347	PKNX1_HUMAN	PBX/knotted 1 homeobox 1	36							sequence-specific DNA binding			large_intestine(2)	2						CTCTGAACCCGATGCAGAAGG	0.493		NaN											0	0	0	0.025465	0	35	190									
ENTHD1	150350	broad.mit.edu	37	22	40139982	40139982	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr22:40139982G>C	uc003ayg.2	-	7	1777	c.1526C>G	c.(1525-1527)TCT>TGT	p.S509C		NM_152512	NP_689725	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	509										ovary(2)|skin(1)	3	Melanoma(58;0.0749)					GTGACTACTAGAAATGTGACT	0.433		NaN											0	0	0	0.004482	0	9	35									
ENTHD1	150350	broad.mit.edu	37	22	40140187	40140187	+	Silent	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr22:40140187G>A	uc003ayg.2	-	7	1572	c.1321C>T	c.(1321-1323)CTG>TTG	p.L441L		NM_152512	NP_689725	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	441										ovary(2)|skin(1)	3	Melanoma(58;0.0749)					GGTCCGGCCAGAATTGGTGAT	0.458		NaN											0	0	0	0.013537	0	12	35									
ENTHD1	150350	broad.mit.edu	37	22	40140202	40140202	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr22:40140202G>C	uc003ayg.2	-	7	1557	c.1306C>G	c.(1306-1308)CTC>GTC	p.L436V		NM_152512	NP_689725	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	436										ovary(2)|skin(1)	3	Melanoma(58;0.0749)					GGTGATAAGAGATGAGCTGAC	0.438		NaN											0	0	0	0.006214	0	9	33									
GRAMD4	23151	broad.mit.edu	37	22	47073091	47073091	+	Silent	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr22:47073091C>T	uc003bhx.2	+	18	1719	c.1680C>T	c.(1678-1680)ACC>ACT	p.T560T	GRAMD4_uc010had.2_Silent_p.T476T|GRAMD4_uc003bhy.2_Silent_p.T83T	NM_015124	NP_055939	Q6IC98	GRAM4_HUMAN	death-inducing-protein	560					apoptosis	integral to membrane|mitochondrial membrane				ovary(1)	1		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|BRCA - Breast invasive adenocarcinoma(115;0.166)		CCTTCGAGACCATTCTCAGCC	0.552		NaN											0	0	0	0.014323	0	17	95									
HDAC10	83933	broad.mit.edu	37	22	50684743	50684743	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr22:50684743G>C	uc003bkg.2	-	17	2007	c.1634C>G	c.(1633-1635)TCC>TGC	p.S545C	TUBGCP6_uc003bkb.1_5'Flank|TUBGCP6_uc010har.1_5'Flank|TUBGCP6_uc010has.1_5'Flank|TUBGCP6_uc010hau.1_5'Flank|HDAC10_uc003bke.2_Missense_Mutation_p.S271C|HDAC10_uc003bkf.2_Missense_Mutation_p.S271C|HDAC10_uc010hav.2_Missense_Mutation_p.S525C|HDAC10_uc003bkh.2_Missense_Mutation_p.S338C|HDAC10_uc003bki.2_Missense_Mutation_p.S495C|HDAC10_uc003bkj.2_RNA	NM_032019	NP_114408	Q969S8	HDA10_HUMAN	histone deacetylase 10 isoform 1	545					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|nucleus	histone deacetylase activity|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CAGTGGCGTGGAGACATGGAA	0.582		NaN											0	0	0	0.010504	0	16	130									
C3orf32	51066	broad.mit.edu	37	3	8667307	8667307	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr3:8667307G>T	uc003bqu.2	-	10	974	c.728C>A	c.(727-729)TCT>TAT	p.S243Y	C3orf32_uc003bqz.2_Missense_Mutation_p.S243Y|C3orf32_uc003bqt.2_Missense_Mutation_p.S192Y|C3orf32_uc011atg.1_Missense_Mutation_p.S265Y|C3orf32_uc003bqv.2_Missense_Mutation_p.S192Y|C3orf32_uc003bqw.2_RNA|C3orf32_uc003bqx.2_RNA|C3orf32_uc003bqy.2_Missense_Mutation_p.S243Y	NM_015931	NP_057015	Q9Y2M2	CC032_HUMAN	hypothetical protein LOC51066	243										skin(1)	1						CCGGTGCTCAGACACAAACTC	0.398		NaN											1	0	1.99824e-07	0.0333	2.13805e-07	14	92									
FANCD2	2177	broad.mit.edu	37	3	10094121	10094121	+	Silent	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr3:10094121C>G	uc003buw.2	+	18	1674	c.1596C>G	c.(1594-1596)CTC>CTG	p.L532L	FANCD2_uc003bux.1_Silent_p.L532L|FANCD2_uc003buy.1_Silent_p.L532L|FANCD2_uc010hcw.1_RNA	NM_033084	NP_149075	Q9BXW9	FACD2_HUMAN	Fanconi anemia complementation group D2 isoform	532					DNA repair|response to gamma radiation	nucleoplasm	protein binding|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.148)		TACGAAAACTCTTCTATGTTC	0.388		NaN	D|Mis|N|F			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.0333	0	13	120									
NGLY1	55768	broad.mit.edu	37	3	25775404	25775404	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr3:25775404C>T	uc003cdl.2	-	8	1327	c.1219G>A	c.(1219-1221)GAA>AAA	p.E407K	NGLY1_uc010hfg.2_Missense_Mutation_p.E389K|NGLY1_uc003cdm.2_Missense_Mutation_p.E407K|NGLY1_uc011awo.1_Missense_Mutation_p.E365K|NGLY1_uc003cdk.2_RNA	NM_018297	NP_060767	Q96IV0	NGLY1_HUMAN	N-glycanase 1 isoform 1	407					glycoprotein catabolic process	cytoplasm	metal ion binding|peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding			breast(1)	1						AGTAATGCTTCTTTAACCTTA	0.343		NaN											0	0	0	0.016723	0	11	112									
MLH1	4292	broad.mit.edu	37	3	37056000	37056000	+	Nonsense_Mutation	SNP	C	C	G	rs121912956		TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr3:37056000C>G	uc003cgl.2	+	9	815	c.755C>G	c.(754-756)TCA>TGA	p.S252*	MLH1_uc011aye.1_Nonsense_Mutation_p.S11*|MLH1_uc011ayb.1_Nonsense_Mutation_p.S11*|MLH1_uc010hge.2_Nonsense_Mutation_p.S252*|MLH1_uc003cgn.3_Nonsense_Mutation_p.S11*|MLH1_uc011ayc.1_Nonsense_Mutation_p.S154*|MLH1_uc011ayd.1_Nonsense_Mutation_p.S11*|MLH1_uc003cgo.2_Nonsense_Mutation_p.S11*|MLH1_uc010hgg.1_5'UTR|MLH1_uc010hgh.1_Intron|MLH1_uc010hgi.1_5'UTR|MLH1_uc010hgj.1_Intron|MLH1_uc010hgk.2_5'UTR|MLH1_uc010hgl.1_5'UTR	NM_000249	NP_000240	P40692	MLH1_HUMAN	MutL protein homolog 1	252			Missing (in HNPCC2).		mismatch repair|somatic hypermutation of immunoglobulin genes	chiasma|MutLalpha complex|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|protein binding	p.S252*(2)|p.0?(1)		large_intestine(40)|haematopoietic_and_lymphoid_tissue(8)|ovary(6)|pancreas(5)|stomach(3)|central_nervous_system(3)|endometrium(3)|breast(3)|prostate(3)|skin(2)|NS(1)	77						GCAAACTACTCAGTGAAGAAG	0.378		1	D|Mis|N|F|S		colorectal|endometrial|ovarian|CNS	colorectal|endometrial|ovarian|CNS		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				0	0	0	0.00308	0	6	70									
ANO10	55129	broad.mit.edu	37	3	43640099	43640099	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr3:43640099C>G	uc003cmv.2	-	4	568	c.397G>C	c.(397-399)GAA>CAA	p.E133Q	ANO10_uc011azs.1_Missense_Mutation_p.E133Q|ANO10_uc003cmw.2_Missense_Mutation_p.E67Q|ANO10_uc010hil.2_Missense_Mutation_p.E133Q|ANO10_uc011azt.1_Intron	NM_018075	NP_060545	Q9NW15	ANO10_HUMAN	transmembrane protein 16K	133	Cytoplasmic (Potential).				cell death	chloride channel complex	chloride channel activity			ovary(2)	2						CTAAGATTTTCAAGTTCATGT	0.313		NaN											0	0	0	0.004672	0	3	42									
DALRD3	55152	broad.mit.edu	37	3	49055271	49055271	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr3:49055271C>T	uc003cvk.1	-	3	513	c.493G>A	c.(493-495)GAT>AAT	p.D165N	DALRD3_uc003cvl.1_Missense_Mutation_p.D165N|DALRD3_uc003cvm.1_5'UTR|DALRD3_uc010hko.1_5'UTR|DALRD3_uc011bca.1_Missense_Mutation_p.D165N|NDUFAF3_uc003cvn.2_5'Flank	NM_001009996	NP_001009996	Q5D0E6	DALD3_HUMAN	DALR anticodon binding domain containing 3	165					arginyl-tRNA aminoacylation	cytoplasm	arginine-tRNA ligase activity|ATP binding				0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		ATGTGCGGATCCCGCACAGCT	0.672		NaN											0	0	0	0.021553	0	5	20									
GNAT1	2779	broad.mit.edu	37	3	50231304	50231304	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr3:50231304C>T	uc003cym.2	+	5	684	c.568C>T	c.(568-570)CTC>TTC	p.L190F	GNAT1_uc003cyl.2_Missense_Mutation_p.L190F	NM_144499	NP_653082	P11488	GNAT1_HUMAN	rod-type transducin alpha subunit	190					detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|negative regulation of cyclic-nucleotide phosphodiesterase activity|rhodopsin mediated phototransduction|sensory perception of umami taste	heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment membrane	acyl binding|G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GDP binding|GTP binding|GTPase activity|protein kinase binding|signal transducer activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		CTTCAAGGATCTCAACTTCCG	0.657		NaN											0	0	0	0.025465	0	30	72									
ALAS1	211	broad.mit.edu	37	3	52233298	52233298	+	Missense_Mutation	SNP	T	T	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr3:52233298T>G	uc003dcy.1	+	3	378	c.41T>G	c.(40-42)GTC>GGC	p.V14G	ALAS1_uc003dcx.1_Missense_Mutation_p.V14G|ALAS1_uc003dcz.1_Missense_Mutation_p.V14G|ALAS1_uc011bec.1_Missense_Mutation_p.V31G	NM_000688	NP_000679	P13196	HEM1_HUMAN	5-aminolevulinate synthase 1 precursor	14					heme biosynthetic process	mitochondrial matrix	5-aminolevulinate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(2)|upper_aerodigestive_tract(1)	3				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.000583)|KIRC - Kidney renal clear cell carcinoma(197;0.000751)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	TTATCCCGAGTCCCCCAGGCC	0.527		NaN											0	0	0	0.008871	0	14	73									
ADAMTS9	56999	broad.mit.edu	37	3	64617494	64617494	+	Silent	SNP	T	T	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr3:64617494T>C	uc003dmg.2	-	15	2315	c.2283A>G	c.(2281-2283)ACA>ACG	p.T761T	ADAMTS9_uc011bfo.1_Silent_p.T733T|ADAMTS9_uc003dmh.1_Silent_p.T590T|ADAMTS9_uc003dmk.1_Silent_p.T761T	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	761	Spacer.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		CATAATGTACTGTATTAAATG	0.358		NaN											0	0	0	0.010504	0	18	86									
CBLB	868	broad.mit.edu	37	3	105377939	105377939	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr3:105377939C>G	uc003dwc.2	-	19	3146	c.2824G>C	c.(2824-2826)GAG>CAG	p.E942Q	CBLB_uc003dwa.2_Missense_Mutation_p.E157Q|CBLB_uc011bhi.1_Missense_Mutation_p.E920Q	NM_170662	NP_733762	Q13191	CBLB_HUMAN	Cas-Br-M (murine) ecotropic retroviral	942	UBA.				cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			lung(4)|ovary(3)|breast(1)|skin(1)	9						GCATAACCCTCTCCCATGAGT	0.512		NaN	Mis S		AML								0	0	0	0.028581	0	13	122									
C3orf1	51300	broad.mit.edu	37	3	119222468	119222468	+	Splice_Site	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr3:119222468G>A	uc003ecn.2	+	3	662	c.449_splice	c.e3+1	p.N150_splice	C3orf1_uc003eco.2_Splice_Site|C3orf1_uc003ecp.2_Splice_Site	NM_016589	NP_057673	Q9NPL8	TIDC1_HUMAN	hypothetical protein LOC51300							integral to membrane|mitochondrial inner membrane	protein transporter activity				0				GBM - Glioblastoma multiforme(114;0.186)		CTATATTCAAGTAAGTTCACT	0.418		NaN											0	0	0	0.004482	0	7	11									
PARP14	54625	broad.mit.edu	37	3	122437553	122437553	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr3:122437553C>T	uc003efq.3	+	14	4614	c.4555C>T	c.(4555-4557)CGA>TGA	p.R1519*	PARP14_uc010hrk.2_RNA|PARP14_uc003efr.2_Nonsense_Mutation_p.R1236*|PARP14_uc003efs.1_Nonsense_Mutation_p.R1236*	NM_017554	NP_060024	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	1519					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			ovary(2)|breast(2)|lung(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(114;0.0531)		CAAGAGAGTTCGATTGGCCAA	0.398		NaN											0	0	0	0.01441	0	49	263									
RASA2	5922	broad.mit.edu	37	3	141326559	141326559	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr3:141326559T>A	uc003etz.1	+	20	1973	c.1973T>A	c.(1972-1974)CTT>CAT	p.L658H	RASA2_uc010huq.1_Missense_Mutation_p.L662H|RASA2_uc003eua.1_Missense_Mutation_p.L659H	NM_006506	NP_006497	Q15283	RASA2_HUMAN	RAS p21 protein activator 2	658	PH.				intracellular signal transduction|negative regulation of Ras protein signal transduction	intracellular membrane-bounded organelle|intrinsic to internal side of plasma membrane|perinuclear region of cytoplasm	metal ion binding|Ras GTPase activator activity			ovary(2)|lung(2)|breast(1)|skin(1)	6						AAAAACATTCTTGCTGTGGAA	0.264		NaN											0	0	0	0.010729	0	8	46									
SERPINI2	5276	broad.mit.edu	37	3	167183420	167183420	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr3:167183420G>C	uc003fer.1	-	3	578	c.520C>G	c.(520-522)CTG>GTG	p.L174V	SERPINI2_uc003fes.1_Missense_Mutation_p.L184V|SERPINI2_uc003fet.1_Missense_Mutation_p.L174V	NM_006217	NP_006208	O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin),	174					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			skin(2)|urinary_tract(1)	3						AGCCGAGTCAGAGGGCCAAAT	0.383		NaN											0	0	0	0.007413	0	14	37									
LRRC31	79782	broad.mit.edu	37	3	169572606	169572606	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr3:169572606G>T	uc003fgc.1	-	6	1063	c.986C>A	c.(985-987)TCA>TAA	p.S329*	LRRC31_uc010hwp.1_Nonsense_Mutation_p.S273*	NM_024727	NP_079003	Q6UY01	LRC31_HUMAN	leucine rich repeat containing 31	329	LRR 4.									ovary(2)|skin(1)	3	all_cancers(22;2.76e-22)|all_epithelial(15;4.73e-27)|all_lung(20;9.24e-17)|Lung NSC(18;3.85e-16)|Ovarian(172;0.000223)|Breast(254;0.197)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00943)			CTTACTCAGTGACATCACGTC	0.398		NaN											1	0	4.15321e-07	0.009535	4.4309e-07	24	98									
PIK3CA	5290	broad.mit.edu	37	3	178936091	178936091	+	Missense_Mutation	SNP	G	G	C	rs104886003		TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr3:178936091G>C	uc003fjk.2	+	10	1790	c.1633G>C	c.(1633-1635)GAG>CAG	p.E545Q		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			0	0	0	0.010504	0	17	58									
EPHB3	2049	broad.mit.edu	37	3	184298213	184298213	+	Silent	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr3:184298213C>T	uc003foz.2	+	12	2633	c.2196C>T	c.(2194-2196)GTC>GTT	p.V732V		NM_004443	NP_004434	P54753	EPHB3_HUMAN	ephrin receptor EphB3 precursor	732	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(5)|breast(2)|upper_aerodigestive_tract(1)|stomach(1)|skin(1)|ovary(1)	11	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			AGTTCACGGTCATCCAGCTGG	0.612		NaN											0	0	0	0.030593	0	23	176									
FAM13A	10144	broad.mit.edu	37	4	89660243	89660243	+	Silent	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr4:89660243G>A	uc003hse.1	-	20	2708	c.2500C>T	c.(2500-2502)CTA>TTA	p.L834L	FAM13A_uc011cdp.1_5'Flank|FAM13A_uc003hsa.1_Silent_p.L305L|FAM13A_uc003hsb.1_Silent_p.L508L|FAM13A_uc003hsd.1_Silent_p.L508L|FAM13A_uc003hsc.1_Silent_p.L494L|FAM13A_uc011cdq.1_Silent_p.L480L|FAM13A_uc003hsf.1_Silent_p.L420L|FAM13A_uc003hsg.1_Silent_p.L305L	NM_014883	NP_055698	O94988	FA13A_HUMAN	family with sequence similarity 13, member A1	834					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)|liver(1)	2						CTGTCGTATAGTGGCTTCATC	0.498		NaN											0	0	0	0.012213	0	23	62									
TMSL3	7117	broad.mit.edu	37	4	91760120	91760120	+	Silent	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr4:91760120C>T	uc003hsy.2	-	1	150	c.69G>A	c.(67-69)ACG>ACA	p.T23T	FAM190A_uc003hsv.3_Intron|FAM190A_uc010ikv.2_Intron|FAM190A_uc003hsx.2_Intron	NM_183049	NP_898870			thymosin-like 3												0		all_cancers(2;6.48e-24)|all_epithelial(2;3.86e-25)|Colorectal(2;8.52e-12)|all_lung(2;3.73e-07)|Lung NSC(2;7.99e-07)|Renal(2;0.0243)|Hepatocellular(203;0.0411)		Epithelial(2;5.28e-11)|OV - Ovarian serous cystadenocarcinoma(123;8.9e-10)|all cancers(2;3.21e-09)|STAD - Stomach adenocarcinoma(1;0.0201)		TTTTCTCTTGCGTCTCTGTCT	0.507		NaN											0	0	0	0.006214	0	9	127									
C4orf21	55345	broad.mit.edu	37	4	113508784	113508784	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr4:113508784C>G	uc003iau.2	-	12	3640	c.3429G>C	c.(3427-3429)CAG>CAC	p.Q1143H	C4orf21_uc003iav.2_RNA	NM_018392	NP_060862	Q6ZU11	YD002_HUMAN	prematurely terminated mRNA decay factor-like	Error:Variant_position_missing_in_Q6ZU11_after_alignment						integral to membrane	zinc ion binding				0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		GCCACTTGCTCTGAGTAGATA	0.403		NaN											0	0	0	0.010729	0	12	41									
ANK2	287	broad.mit.edu	37	4	114275328	114275328	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr4:114275328G>T	uc003ibe.3	+	38	5654	c.5554G>T	c.(5554-5556)GAG>TAG	p.E1852*	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_5'Flank|ANK2_uc011cgb.1_Nonsense_Mutation_p.E1867*	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	1819	Repeat A.|Repeat-rich region.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AAGTAAAACTGAGAAACACTC	0.478		NaN											1	0	3.40343e-31	0.01441	3.92785e-31	46	137									
ANK2	287	broad.mit.edu	37	4	114275400	114275400	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr4:114275400G>A	uc003ibe.3	+	38	5726	c.5626G>A	c.(5626-5628)GAG>AAG	p.E1876K	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_5'Flank|ANK2_uc011cgb.1_Missense_Mutation_p.E1891K	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	1843	Repeat A.|Repeat-rich region.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GAGTAAAACTGAGAAACACTC	0.458		NaN											0	0	0	0.01441	0	43	128									
EXOSC9	5393	broad.mit.edu	37	4	122735121	122735121	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr4:122735121G>A	uc003iea.2	+	10	1183	c.1075G>A	c.(1075-1077)GAA>AAA	p.E359K	EXOSC9_uc003idz.2_Missense_Mutation_p.E359K|EXOSC9_uc003ieb.2_Missense_Mutation_p.E343K|EXOSC9_uc010inp.1_RNA	NM_005033	NP_005024	Q06265	EXOS9_HUMAN	exosome component 9 isoform 2	359					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|immune response|nuclear mRNA surveillance|nuclear polyadenylation-dependent rRNA catabolic process|positive regulation of cell growth|rRNA processing	cytosol|nuclear exosome (RNase complex)|nucleolus|nucleolus|nucleus	3'-5'-exoribonuclease activity|AU-rich element binding|protein binding				0						GGAAGATGATGAAGGCGGTGG	0.453		NaN											0	0	0	0.017118	0	32	87									
BBS7	55212	broad.mit.edu	37	4	122766713	122766713	+	Silent	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr4:122766713G>A	uc003ied.2	-	11	1350	c.1176C>T	c.(1174-1176)GCC>GCT	p.A392A	BBS7_uc003iee.1_Silent_p.A392A	NM_176824	NP_789794	Q8IWZ6	BBS7_HUMAN	Bardet-Biedl syndrome 7 protein isoform a	392					cilium morphogenesis|digestive tract morphogenesis|fat cell differentiation|heart looping|melanosome transport|pigment granule aggregation in cell center|response to stimulus|visual perception	BBSome|centrosome|cilium membrane	protein binding			ovary(1)	1						GGCTGTAACTGGCATCATCTT	0.313		NaN							Bardet-Biedl_syndrome				0	0	0	0.020292	0	12	44									
C4orf51	646603	broad.mit.edu	37	4	146653608	146653608	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr4:146653608C>T	uc003ikk.2	+	6	505	c.505C>T	c.(505-507)CAT>TAT	p.H169Y		NM_001080531	NP_001074000	C9J302	CD051_HUMAN	chromosome 4 open reading frame 51	169											0						TCTCCAGCTTCATGGACGGTG	0.473		NaN											0	0	0	0.02938	0	6	23									
DCLK2	166614	broad.mit.edu	37	4	151124998	151124998	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr4:151124998C>G	uc003ilm.3	+	5	1113	c.1013C>G	c.(1012-1014)TCC>TGC	p.S338C	DCLK2_uc003iln.3_Missense_Mutation_p.S338C|DCLK2_uc003ilo.3_Missense_Mutation_p.S355C|DCLK2_uc003ilp.3_RNA	NM_001040260	NP_001035350	Q8N568	DCLK2_HUMAN	doublecortin-like kinase 2 isoform a	338	Ser-rich.				intracellular signal transduction	cytoplasm|cytoskeleton	ATP binding|protein serine/threonine kinase activity			ovary(3)	3	all_hematologic(180;0.151)					ACGAAATCCTCCAGTTCCTCT	0.393		NaN											0	0	0	0.012319	0	18	109									
FHDC1	85462	broad.mit.edu	37	4	153893636	153893636	+	Silent	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr4:153893636G>A	uc003inf.2	+	10	1401	c.1326G>A	c.(1324-1326)CTG>CTA	p.L442L		NM_033393	NP_203751	Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	442	FH2.				actin cytoskeleton organization		actin binding			large_intestine(1)|ovary(1)	2	all_hematologic(180;0.093)					CCATGAAACTGGATGAATGCT	0.393		NaN											0	0	0	0.010504	0	19	81									
GUCY1A3	2982	broad.mit.edu	37	4	156638380	156638380	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr4:156638380C>T	uc003iov.2	+	9	2178	c.1642C>T	c.(1642-1644)CAG>TAG	p.Q548*	GUCY1A3_uc010iqc.2_Nonsense_Mutation_p.Q548*|GUCY1A3_uc003iow.2_Nonsense_Mutation_p.Q548*|GUCY1A3_uc010iqd.2_Nonsense_Mutation_p.Q547*|GUCY1A3_uc003iox.2_Nonsense_Mutation_p.Q548*|GUCY1A3_uc003ioz.2_Nonsense_Mutation_p.Q313*|GUCY1A3_uc003ioy.2_Nonsense_Mutation_p.Q548*|GUCY1A3_uc010iqe.2_Nonsense_Mutation_p.Q313*|GUCY1A3_uc003ipa.2_RNA|GUCY1A3_uc003ipb.2_Nonsense_Mutation_p.Q548*	NM_000856	NP_000847	Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3 isoform A	548	Guanylate cyclase.				blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		TCATGCTGTTCAGATAGCGCT	0.423		NaN											0	0	0	0.0333	0	14	54									
EXOC3	11336	broad.mit.edu	37	5	453801	453801	+	Silent	SNP	T	T	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr5:453801T>A	uc003jba.2	+	4	809	c.681T>A	c.(679-681)CTT>CTA	p.L227L		NM_007277	NP_009208	O60645	EXOC3_HUMAN	Sec6 protein	238					exocytosis|protein transport						0		Ovarian(839;0.0563)	Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			GGCGCATACTTGACCGGAAAA	0.507		NaN											0	0	0	0.01892	0	21	91									
ADCY2	108	broad.mit.edu	37	5	7773096	7773096	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr5:7773096C>T	uc003jdz.1	+	18	2333	c.2266C>T	c.(2266-2268)CGG>TGG	p.R756W	ADCY2_uc011cmo.1_Missense_Mutation_p.R576W	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	756					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						CGTGTTCCTGCGGGTAAACTA	0.502		NaN											0	0	0	0.037714	0	26	126									
SEMA5A	9037	broad.mit.edu	37	5	9197325	9197325	+	Silent	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr5:9197325C>T	uc003jek.2	-	10	1735	c.1023G>A	c.(1021-1023)TCG>TCA	p.S341S		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	341	Sema.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						AGGCCGAGCGCGAGTTTTCTT	0.592		NaN											0	0	0	0.007413	0	18	64									
TRIO	7204	broad.mit.edu	37	5	14387596	14387596	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr5:14387596G>C	uc003jff.2	+	22	3626	c.3620G>C	c.(3619-3621)TGT>TCT	p.C1207S	TRIO_uc003jfg.2_RNA|TRIO_uc011cna.1_Missense_Mutation_p.C1158S|TRIO_uc003jfh.1_Missense_Mutation_p.C856S	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	1207	Spectrin 4.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					GATGGCTTTTGTGAAAAAGGG	0.448		NaN											0	0	0	0.014323	0	19	73									
ITGA2	3673	broad.mit.edu	37	5	52377489	52377489	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr5:52377489C>T	uc003joy.2	+	26	3250	c.3107C>T	c.(3106-3108)TCT>TTT	p.S1036F	ITGA2_uc011cqa.1_RNA|ITGA2_uc011cqb.1_RNA|ITGA2_uc011cqc.1_Missense_Mutation_p.S960F|ITGA2_uc011cqd.1_RNA|ITGA2_uc011cqe.1_RNA	NM_002203	NP_002194	P17301	ITA2_HUMAN	integrin alpha 2 precursor	1036	Extracellular (Potential).				axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			lung(1)	1		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				TCTTCTGTATCTTTCAAAAGT	0.398		NaN											0	0	0	0.00308	0	6	20									
MAP1B	4131	broad.mit.edu	37	5	71490041	71490041	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr5:71490041G>A	uc003kbw.3	+	5	1100	c.859G>A	c.(859-861)GGA>AGA	p.G287R	MAP1B_uc010iyw.1_Missense_Mutation_p.G304R|MAP1B_uc010iyx.1_Missense_Mutation_p.G161R|MAP1B_uc010iyy.1_Missense_Mutation_p.G161R	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	287						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		CATCAATGGCGGATCAGAGAG	0.483		NaN											0	0	0	0.0333	0	17	95									
ANKRD34B	340120	broad.mit.edu	37	5	79854455	79854455	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr5:79854455C>A	uc010jam.2	-	4	1734	c.1384G>T	c.(1384-1386)GAT>TAT	p.D462Y	ANKRD34B_uc003kgw.2_Missense_Mutation_p.D462Y|ANKRD34B_uc010jan.2_Missense_Mutation_p.D462Y	NM_001004441	NP_001004441	A5PLL1	AN34B_HUMAN	ankyrin repeat domain 34B	462						cytoplasm|nucleus				pancreas(1)	1		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-46)|Epithelial(54;5.64e-41)|all cancers(79;3.24e-36)		ACATTGATATCTGAGATGGGA	0.413		NaN											1	0	6.97489e-18	0.021022	7.8521e-18	31	160									
YTHDC2	64848	broad.mit.edu	37	5	112915339	112915339	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr5:112915339A>G	uc003kqn.2	+	24	3484	c.3301A>G	c.(3301-3303)AAT>GAT	p.N1101D		NM_022828	NP_073739	Q9H6S0	YTDC2_HUMAN	YTH domain containing 2	1101							ATP binding|ATP-dependent helicase activity|nucleic acid binding			skin(2)|central_nervous_system(1)	3		all_cancers(142;7.69e-05)|all_epithelial(76;6.42e-07)|Colorectal(10;0.00278)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Lung NSC(810;0.143)|all_lung(232;0.163)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;7.2e-08)|Epithelial(69;8.83e-08)|all cancers(49;6.9e-06)|COAD - Colon adenocarcinoma(37;0.0458)|Colorectal(14;0.0594)		AACTACAGCTAATTTGGCAGC	0.373		NaN											0	0	0	0.01441	0	61	138									
PAIP2	51247	broad.mit.edu	37	5	138700267	138700267	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr5:138700267A>T	uc003led.2	+	3	330	c.153A>T	c.(151-153)TTA>TTT	p.L51F	PAIP2_uc003lee.2_Missense_Mutation_p.L51F|PAIP2_uc003lef.2_Missense_Mutation_p.L51F	NM_016480	NP_057564	Q9BPZ3	PAIP2_HUMAN	poly(A) binding protein interacting protein 2	51	Glu-rich.|PABPC1-interacting motif-1 (PAM1).				negative regulation of translational initiation	cytoplasm	protein binding|translation repressor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			AAGAGGAGTTATGGGAAGAAG	0.348		NaN											0	0	0	0.008291	0	7	49									
PCDHA8	56140	broad.mit.edu	37	5	140222772	140222772	+	Silent	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr5:140222772C>T	uc003lhs.2	+	1	1866	c.1866C>T	c.(1864-1866)TTC>TTT	p.F622F	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Silent_p.F622F	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	622	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCATCCCGTTCCGCGTGGGGC	0.647		NaN											0	0	0	0.01441	0	49	109									
PCDHB14	56122	broad.mit.edu	37	5	140603436	140603436	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr5:140603436A>G	uc003ljb.2	+	1	359	c.359A>G	c.(358-360)GAG>GGG	p.E120G	PCDHB14_uc011dal.1_Intron	NM_018934	NP_061757	Q9Y5E9	PCDBE_HUMAN	protocadherin beta 14 precursor	120	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTTCGGTTTGAGCTGTGTGTC	0.423		NaN											0	0	0	0.009535	0	24	85									
POU4F3	5459	broad.mit.edu	37	5	145719138	145719138	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr5:145719138G>C	uc003loa.2	+	2	237	c.148G>C	c.(148-150)GAT>CAT	p.D50H		NM_002700	NP_002691	Q15319	PO4F3_HUMAN	POU class 4 homeobox 3	50					sensory perception of sound|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGGAAGCTTTGATGAGAGCCT	0.537		NaN											0	0	0	0.017118	0	31	46									
KIF4B	285643	broad.mit.edu	37	5	154395261	154395261	+	Silent	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr5:154395261G>A	uc010jih.1	+	1	2002	c.1842G>A	c.(1840-1842)AAG>AAA	p.K614K		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	614	Potential.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			ATCTGAAGAAGAAACTGAATG	0.463		NaN											0	0	0	0.019004	0	29	54									
ITK	3702	broad.mit.edu	37	5	156679642	156679642	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr5:156679642C>T	uc003lwo.1	+	17	1899	c.1817C>T	c.(1816-1818)TCC>TTC	p.S606F		NM_005546	NP_005537	Q08881	ITK_HUMAN	IL2-inducible T-cell kinase	606	Protein kinase.				cellular defense response|intracellular signal transduction|T cell receptor signaling pathway	cytosol|plasma membrane	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(12)|ovary(8)|skin(4)|stomach(1)|central_nervous_system(1)	26	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.1)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CCAGCCTTCTCCAGACTGCTG	0.468		NaN	T	SYK	peripheral T-cell lymphoma								0	0	0	0.01441	0	37	67									
TFAP2A	7020	broad.mit.edu	37	6	10404842	10404842	+	Silent	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr6:10404842G>A	uc003myr.2	-	4	915	c.663C>T	c.(661-663)CTC>CTT	p.L221L	TFAP2A_uc003myq.2_Silent_p.L215L|TFAP2A_uc003mys.2_RNA|TFAP2A_uc011dih.1_Silent_p.L221L|TFAP2A_uc003myt.2_Silent_p.L217L|TFAP2A_uc003myu.1_Silent_p.L221L	NM_003220	NP_003211	P05549	AP2A_HUMAN	transcription factor AP-2 alpha isoform a	221					ectoderm development|positive regulation of bone mineralization|positive regulation of tooth mineralization|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	centrosome|Golgi apparatus|nucleus	chromatin binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			ovary(1)	1	Breast(50;0.0427)|Ovarian(93;0.0991)	all_hematologic(90;0.107)				AGGTGGAGCTGAGGAGCGAGA	0.622		NaN											0	0	0	0.0333	0	14	29									
HSPA1L	3305	broad.mit.edu	37	6	31777967	31777967	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr6:31777967C>T	uc003nxh.2	-	2	1966	c.1783G>A	c.(1783-1785)GAT>AAT	p.D595N	HSPA1L_uc010jte.2_Missense_Mutation_p.D595N	NM_005527	NP_005518	P34931	HS71L_HUMAN	heat shock 70kDa protein 1-like	595					response to unfolded protein		ATP binding			ovary(3)|pleura(1)|kidney(1)|skin(1)	6						CTCTTATGATCAAACTCATCT	0.448		NaN											0	0	0	0.030466	0	32	97									
GPSM3	63940	broad.mit.edu	37	6	32159216	32159216	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr6:32159216T>C	uc003oay.3	-	4	803	c.410A>G	c.(409-411)GAG>GGG	p.E137G	PBX2_uc003oav.1_5'Flank|PBX2_uc003oaw.2_5'Flank|GPSM3_uc003oax.3_Missense_Mutation_p.E114G|GPSM3_uc003oaz.2_Missense_Mutation_p.E137G	NM_022107	NP_071390	Q9Y4H4	GPSM3_HUMAN	G-protein signaling modulator 3 (AGS3-like, C.	137	GoLoco 3.				signal transduction	cytoplasm	GTPase activator activity|protein binding				0						CAGCAGCAACTCCAGGAGCTC	0.642		NaN											0	0	0	0.010818	0	31	51									
COL21A1	81578	broad.mit.edu	37	6	56006588	56006588	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr6:56006588C>G	uc003pcs.2	-	12	1769	c.1537G>C	c.(1537-1539)GAC>CAC	p.D513H	COL21A1_uc003pct.1_RNA|COL21A1_uc011dxi.1_Missense_Mutation_p.D513H|COL21A1_uc003pcu.1_Missense_Mutation_p.D510H	NM_030820	NP_110447	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1 precursor	513					cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(2)	2	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			TTTACCTTGTCACCATCTCGC	0.388		NaN											0	0	0	0.01892	0	19	59									
ZNF292	23036	broad.mit.edu	37	6	87971379	87971379	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr6:87971379A>G	uc003plm.3	+	8	8073	c.8032A>G	c.(8032-8034)ACT>GCT	p.T2678A		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	2678					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		TAAAGATTGCACTGAGCTTGT	0.348		NaN											0	0	0	0.02938	0	7	16									
AIM1	202	broad.mit.edu	37	6	106975304	106975304	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr6:106975304G>C	uc003prh.2	+	5	3800	c.3313G>C	c.(3313-3315)GAT>CAT	p.D1105H		NM_001624	NP_001615	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	1105	Beta/gamma crystallin 'Greek key' 2.						sugar binding			breast(4)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	9	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		AGCAGAGTCTGATAAGCCAGT	0.403		NaN											0	0	0	0.01441	0	52	258									
LAMA2	3908	broad.mit.edu	37	6	129573422	129573422	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr6:129573422G>A	uc003qbn.2	+	14	2183	c.2078G>A	c.(2077-2079)GGG>GAG	p.G693E	LAMA2_uc003qbo.2_Missense_Mutation_p.G693E	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	693	Laminin IV type A 1.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TACAGCTTTGGGATGGATGCC	0.448		NaN											0	0	0	0.00308	0	7	62									
EPB41L2	2037	broad.mit.edu	37	6	131190961	131190961	+	Silent	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr6:131190961C>T	uc003qch.2	-	15	2531	c.2349G>A	c.(2347-2349)CCG>CCA	p.P783P	EPB41L2_uc003qce.1_Silent_p.P161P|EPB41L2_uc003qcf.1_Intron|EPB41L2_uc003qcg.1_Intron|EPB41L2_uc011eby.1_Intron|EPB41L2_uc003qci.2_Silent_p.P713P|EPB41L2_uc010kfk.2_Intron|EPB41L2_uc010kfl.1_Silent_p.P713P|EPB41L2_uc003qcd.1_5'Flank|EPB41L2_uc003qcj.1_Silent_p.P180P	NM_001431	NP_001422	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	783					cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			central_nervous_system(1)|skin(1)	2	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		CCTTGGCTGCCGGGCGGGGTT	0.577		NaN											0	0	0	0.01441	0	47	220									
TAAR9	134860	broad.mit.edu	37	6	132860331	132860331	+	Nonsense_Mutation	SNP	T	T	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr6:132860331T>A	uc011eci.1	+	2	905	c.903T>A	c.(901-903)TAT>TAA	p.Y301*		NM_175057	NP_778227	Q96RI9	TAAR9_HUMAN	trace amine associated receptor 9	301	Helical; Name=7; (Potential).					plasma membrane	G-protein coupled receptor activity				0	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.0042)|GBM - Glioblastoma multiforme(226;0.00816)		GGTGTGTTTATTATAATTCAG	0.348		NaN											0	0	0	0.014758	0	4	12									
SHPRH	257218	broad.mit.edu	37	6	146256489	146256489	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr6:146256489C>G	uc003qlf.2	-	12	3057	c.2658G>C	c.(2656-2658)AAG>AAC	p.K886N	SHPRH_uc003qld.2_Missense_Mutation_p.K886N|SHPRH_uc003qle.2_Missense_Mutation_p.K886N|SHPRH_uc003qlg.1_Missense_Mutation_p.K442N|SHPRH_uc003qlj.1_Missense_Mutation_p.K775N|SHPRH_uc003qlh.2_5'Flank	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	886					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		GAGGATTCTTCTTGCAGTAAG	0.393		NaN											0	0	0	0.020292	0	14	47									
IPCEF1	26034	broad.mit.edu	37	6	154521101	154521101	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr6:154521101G>T	uc003qpx.2	-	10	764	c.608C>A	c.(607-609)ACA>AAA	p.T203K	OPRM1_uc003qpt.1_Intron|IPCEF1_uc003qpv.2_Missense_Mutation_p.T74K|IPCEF1_uc003qpw.2_Missense_Mutation_p.T204K|IPCEF1_uc010kjh.2_Missense_Mutation_p.T204K	NM_015553	NP_056368	Q8WWN9	ICEF1_HUMAN	phosphoinositide-binding protein PIP3-E isoform	203	Ser-rich.				response to oxidative stress	cytoplasm|plasma membrane	oxygen transporter activity|peroxidase activity				0						TGTCTTCACTGTATTTTCCAG	0.433		NaN											1	0	0.00621372	0.006214	0.00631699	8	91									
FNDC1	84624	broad.mit.edu	37	6	159653694	159653694	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr6:159653694C>G	uc010kjv.2	+	11	2350	c.2150C>G	c.(2149-2151)TCA>TGA	p.S717*	FNDC1_uc010kjw.1_Nonsense_Mutation_p.S602*	NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	717	Ser-rich.					extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		GCCCCACCCTCAAGACTTTCT	0.657		NaN											0	0	0	0.02938	0	7	16									
ZNF12	7559	broad.mit.edu	37	7	6730643	6730643	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:6730643G>A	uc003sqt.1	-	5	2484	c.1930C>T	c.(1930-1932)CGG>TGG	p.R644W	ZNF12_uc011jxa.1_Missense_Mutation_p.R482W|ZNF12_uc003sqs.1_Missense_Mutation_p.R606W	NM_016265	NP_057349	P17014	ZNF12_HUMAN	zinc finger protein 12 isoform a	644	C2H2-type 14.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0231)		TATGACATCCGAGAGAAGGCT	0.393		NaN											0	0	0	0.01441	0	46	95									
ZNF12	7559	broad.mit.edu	37	7	6730858	6730858	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:6730858G>A	uc003sqt.1	-	5	2269	c.1715C>T	c.(1714-1716)TCA>TTA	p.S572L	ZNF12_uc011jxa.1_Missense_Mutation_p.S410L|ZNF12_uc003sqs.1_Missense_Mutation_p.S534L	NM_016265	NP_057349	P17014	ZNF12_HUMAN	zinc finger protein 12 isoform a	572					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0231)		CTTCTCTCCTGAATGAATTCT	0.413		NaN											0	0	0	0.012319	0	16	65									
ZNF12	7559	broad.mit.edu	37	7	6730881	6730881	+	Silent	SNP	G	G	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:6730881G>C	uc003sqt.1	-	5	2246	c.1692C>G	c.(1690-1692)CTC>CTG	p.L564L	ZNF12_uc011jxa.1_Silent_p.L402L|ZNF12_uc003sqs.1_Silent_p.L526L	NM_016265	NP_057349	P17014	ZNF12_HUMAN	zinc finger protein 12 isoform a	564	C2H2-type 11.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0231)		GATGTATAGTGAGGTATGACA	0.408		NaN											0	0	0	0.008871	0	15	58									
DGKB	1607	broad.mit.edu	37	7	14724975	14724975	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:14724975C>T	uc003ssz.2	-	9	911	c.724G>A	c.(724-726)GAT>AAT	p.D242N	DGKB_uc011jxt.1_Missense_Mutation_p.D235N|DGKB_uc003sta.2_Missense_Mutation_p.D242N|DGKB_uc011jxu.1_Missense_Mutation_p.D242N|DGKB_uc011jxv.1_Missense_Mutation_p.D242N	NM_004080	NP_004071	Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta isoform 1	242					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			lung(5)|ovary(4)|breast(2)|skin(1)	12					Phosphatidylserine(DB00144)	TGCTGTCCATCATCCTTCACG	0.463		NaN											0	0	0	0.021523	0	19	72									
DNAH11	8701	broad.mit.edu	37	7	21723453	21723453	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:21723453G>T	uc003svc.2	+	33	5564	c.5533G>T	c.(5533-5535)GAG>TAG	p.E1845*		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1845	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TCACCGATGGGAGGATACCCA	0.458		NaN							Kartagener_syndrome				1	0	3.28156e-27	0.01441	3.76353e-27	50	279									
STK31	56164	broad.mit.edu	37	7	23802426	23802426	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:23802426G>A	uc003sws.3	+	11	1367	c.1300G>A	c.(1300-1302)GGG>AGG	p.G434R	STK31_uc003swt.3_Missense_Mutation_p.G411R|STK31_uc011jze.1_Missense_Mutation_p.G434R|STK31_uc010kuq.2_Missense_Mutation_p.G411R	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	434							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						CCAGAGTGAAGGGAATATTTT	0.333		NaN											0	0	0	0.027894	0	37	66									
ADCYAP1R1	117	broad.mit.edu	37	7	31132288	31132288	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:31132288G>T	uc003tca.1	+	13	1208	c.985G>T	c.(985-987)GTC>TTC	p.V329F	ADCYAP1R1_uc003tcb.1_Missense_Mutation_p.V308F|ADCYAP1R1_uc003tcc.1_Missense_Mutation_p.V329F|ADCYAP1R1_uc003tcd.1_Missense_Mutation_p.V329F|ADCYAP1R1_uc003tce.1_Missense_Mutation_p.V329F|ADCYAP1R1_uc003tcf.1_Missense_Mutation_p.V31F	NM_001118	NP_001109	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1	329	Helical; Name=5; (Potential).				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			ovary(1)	1						TGGCATTATCGTCATCCTTGT	0.428		NaN											1	0	4.7546e-09	0.028581	5.20878e-09	15	73									
OGDH	4967	broad.mit.edu	37	7	44734097	44734097	+	Silent	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:44734097C>T	uc003tln.2	+	12	1699	c.1590C>T	c.(1588-1590)ATC>ATT	p.I530I	OGDH_uc011kbx.1_Silent_p.I526I|OGDH_uc011kby.1_Silent_p.I380I|OGDH_uc003tlp.2_Silent_p.I541I|OGDH_uc011kbz.1_Silent_p.I325I|OGDH_uc003tlo.1_Silent_p.I363I	NM_002541	NP_002532	Q02218	ODO1_HUMAN	oxoglutarate dehydrogenase isoform 1 precursor	530					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			upper_aerodigestive_tract(1)|ovary(1)	2					NADH(DB00157)	ACAAGCAGATCCGCAAGCAGA	0.572		NaN											0	0	0	0.037714	0	25	61									
HUS1	3364	broad.mit.edu	37	7	48004979	48004979	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:48004979G>A	uc003tod.1	-	8	947	c.817C>T	c.(817-819)CAG>TAG	p.Q273*	HUS1_uc003toe.1_Nonsense_Mutation_p.Q273*|HUS1_uc011kce.1_RNA	NM_004507	NP_004498	O60921	HUS1_HUMAN	HUS1 checkpoint protein	273					DNA damage checkpoint|DNA replication	Golgi apparatus|nucleolus|nucleoplasm	protein binding			ovary(2)|lung(2)|kidney(1)	5		Breast(660;0.00139)				ATGAAATACTGAAGGGACACG	0.483		NaN						Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					0	0	0	0.025465	0	33	115									
CCT6A	908	broad.mit.edu	37	7	56126340	56126340	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:56126340C>G	uc003trl.1	+	8	1077	c.913C>G	c.(913-915)CTT>GTT	p.L305V	PSPH_uc003trj.2_Intron|CCT6A_uc003trm.1_Missense_Mutation_p.L260V|CCT6A_uc011kcu.1_Missense_Mutation_p.L274V|SNORA15_uc003trn.1_5'Flank	NM_001762	NP_001753	P40227	TCPZ_HUMAN	chaperonin containing TCP1, subunit 6A isoform	305					'de novo' posttranslational protein folding	cytosol	ATP binding|unfolded protein binding			upper_aerodigestive_tract(1)	1	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			CTTAGATGCTCTTTCAAAAGA	0.343		NaN											0	0	0	0.0333	0	14	45									
CROT	54677	broad.mit.edu	37	7	87020948	87020948	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:87020948C>T	uc003uit.2	+	14	1590	c.1345C>T	c.(1345-1347)CAT>TAT	p.H449Y	CROT_uc003uiu.2_Missense_Mutation_p.H477Y	NM_021151	NP_066974	Q9UKG9	OCTC_HUMAN	peroxisomal carnitine O-octanoyltransferase	449					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|transport	peroxisomal matrix	carnitine O-octanoyltransferase activity			ovary(2)|lung(1)	3	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)				L-Carnitine(DB00583)	ACATTTTTATCATGGCCGTAC	0.388		NaN											0	0	0	0.037714	0	23	46									
DBF4	10926	broad.mit.edu	37	7	87529553	87529553	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:87529553A>G	uc003ujf.1	+	9	1202	c.698A>G	c.(697-699)TAT>TGT	p.Y233C	DBF4_uc003ujh.1_Intron|DBF4_uc003ujg.1_Missense_Mutation_p.Y9C|DBF4_uc011khf.1_Intron	NM_006716	NP_006707	Q9UBU7	DBF4A_HUMAN	activator of S phase kinase	233					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	enzyme activator activity|nucleic acid binding|protein binding|zinc ion binding			lung(2)	2	Esophageal squamous(14;0.00202)	Breast(660;0.0334)				AGGCCATTTTATCTTCAGCTG	0.299		NaN											0	0	0	0.008291	0	9	66									
MTERF	7978	broad.mit.edu	37	7	91503486	91503486	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:91503486G>C	uc003ulb.1	-	2	666	c.622C>G	c.(622-624)CTT>GTT	p.L208V	MTERF_uc010let.1_Intron|MTERF_uc003ulc.1_Missense_Mutation_p.L208V|MTERF_uc011khm.1_Missense_Mutation_p.L188V|MTERF_uc010leu.1_Missense_Mutation_p.L188V	NM_006980	NP_008911	Q99551	MTERF_HUMAN	mitochondrial transcription termination factor	208					DNA geometric change|regulation of transcription, DNA-dependent|termination of mitochondrial transcription	mitochondrial nucleoid	double-stranded DNA binding				0	all_cancers(62;2.28e-09)|all_epithelial(64;1.07e-07)|Breast(17;0.00371)|all_hematologic(106;0.091)|all_lung(186;0.178)|Lung NSC(181;0.235)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.0993)|Kidney(17;0.118)|Epithelial(20;0.136)|LUSC - Lung squamous cell carcinoma(200;0.176)			TTCAGATCAAGACTATTGGAG	0.383		NaN											0	0	0	0.013537	0	12	66									
COL1A2	1278	broad.mit.edu	37	7	94053674	94053674	+	Silent	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:94053674G>A	uc003ung.1	+	41	3063	c.2592G>A	c.(2590-2592)CAG>CAA	p.Q864Q	COL1A2_uc011kib.1_Intron|COL1A2_uc010lfi.1_RNA	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	864					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	CAGGTCCTCAGGGTCTTCTTG	0.498		NaN								HNSCC(75;0.22)			0	0	0	0.020292	0	10	94									
TMEM130	222865	broad.mit.edu	37	7	98449087	98449087	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:98449087G>C	uc003upo.2	-	6	1152	c.963C>G	c.(961-963)ATC>ATG	p.I321M	TMEM130_uc011kiq.1_Missense_Mutation_p.I302M|TMEM130_uc011kir.1_Missense_Mutation_p.I321M|TMEM130_uc003upn.2_Missense_Mutation_p.I219M	NM_001134450	NP_001127922	Q8N3G9	TM130_HUMAN	transmembrane protein 130 isoform a	321	Extracellular (Potential).					Golgi membrane|integral to membrane				ovary(1)|central_nervous_system(1)	2	all_cancers(62;4.05e-09)|all_epithelial(64;2.62e-09)|Lung NSC(181;0.01)|all_lung(186;0.0115)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			GTGTCTTGCTGATGATATTCT	0.582		NaN											0	0	0	0.016723	0	11	106									
ZKSCAN5	23660	broad.mit.edu	37	7	99123756	99123756	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:99123756C>T	uc003uqv.2	+	6	1217	c.1093C>T	c.(1093-1095)CGG>TGG	p.R365W	ZKSCAN5_uc010lfx.2_Missense_Mutation_p.R365W|ZKSCAN5_uc003uqw.2_Missense_Mutation_p.R365W|ZKSCAN5_uc003uqx.2_Missense_Mutation_p.R292W|ZKSCAN5_uc003uqy.2_Missense_Mutation_p.R101W	NM_145102	NP_659570	Q9Y2L8	ZKSC5_HUMAN	zinc finger with KRAB and SCAN domains 5	365	C2H2-type 1.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					TATTCAGCATCGGCGCATCCA	0.537		NaN											0	0	0	0.020292	0	14	82									
VGF	7425	broad.mit.edu	37	7	100806828	100806828	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:100806828C>T	uc003uxx.3	-	2	1515	c.1297G>A	c.(1297-1299)GAG>AAG	p.E433K		NM_003378	NP_003369	O15240	VGF_HUMAN	VGF nerve growth factor inducible precursor	433	Asp/Glu-rich (acidic).				response to cAMP	extracellular space|transport vesicle	growth factor activity				0	Lung NSC(181;0.168)|all_lung(186;0.215)					tctgtcccctcggcctccttc	0.493		NaN											0	0	0	0.004482	0	9	9									
PTPRZ1	5803	broad.mit.edu	37	7	121650934	121650934	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:121650934G>A	uc003vjy.2	+	12	2229	c.1834G>A	c.(1834-1836)GAA>AAA	p.E612K	PTPRZ1_uc003vjz.2_Missense_Mutation_p.E612K|PTPRZ1_uc011knt.1_Missense_Mutation_p.E62K	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	612	Extracellular (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						ATTTTCCTCCGAAAACCCAGA	0.418		NaN											0	0	0	0.024245	0	12	33									
PLXNA4	91584	broad.mit.edu	37	7	131866328	131866328	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:131866328C>T	uc003vra.3	-	18	3533	c.3304G>A	c.(3304-3306)GCT>ACT	p.A1102T		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1102	Extracellular (Potential).|IPT/TIG 3.					integral to membrane|intracellular|plasma membrane				ovary(1)	1						GGACCCAGAGCGAGGGCGGGC	0.577		NaN											0	0	0	0.014323	0	21	36									
DGKI	9162	broad.mit.edu	37	7	137150661	137150661	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:137150661C>T	uc003vtt.2	-	27	2630	c.2629G>A	c.(2629-2631)GCC>ACC	p.A877T	DGKI_uc003vtu.2_Missense_Mutation_p.A587T	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	877					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						CACCCCGAGGCTTGTTCCACC	0.542		NaN											0	0	0	0.013537	0	10	59									
FAM115C	285966	broad.mit.edu	37	7	143417071	143417071	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:143417071C>G	uc003wdf.2	+	3	1002	c.919C>G	c.(919-921)CTA>GTA	p.L307V	FAM115C_uc003wdg.2_Missense_Mutation_p.L26V|FAM115C_uc011ktk.1_Missense_Mutation_p.L307V|FAM115C_uc003wdh.2_Missense_Mutation_p.L307V|FAM115C_uc011ktm.1_Missense_Mutation_p.L307V|uc011ktn.1_Intron|uc011kto.1_Intron|uc011ktp.1_Intron|LOC154761_uc011ktq.1_Intron|LOC154761_uc011ktr.1_Intron|LOC154761_uc011kts.1_Intron|FAM115C_uc011ktt.1_Missense_Mutation_p.L143V|FAM115C_uc003wdi.1_Missense_Mutation_p.L26V	NM_001130025	NP_001123497	A6NFQ2	F115C_HUMAN	hypothetical protein LOC285966 isoform A	307											0						GAACACAAATCTAAAAGATCT	0.572		NaN											0	0	0	0.014758	0	5	26									
ANK1	286	broad.mit.edu	37	8	41554068	41554068	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr8:41554068A>T	uc003xok.2	-	26	2857	c.2773T>A	c.(2773-2775)TCC>ACC	p.S925T	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Missense_Mutation_p.S241T|ANK1_uc003xoi.2_Missense_Mutation_p.S925T|ANK1_uc003xoj.2_Missense_Mutation_p.S925T|ANK1_uc003xol.2_Missense_Mutation_p.S925T|ANK1_uc003xom.2_Missense_Mutation_p.S966T	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	925	ZU5.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CCTCTCATGGAACCACCCCGG	0.637		NaN											0	0	0	0.020292	0	14	25									
KIAA0146	23514	broad.mit.edu	37	8	48309024	48309024	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr8:48309024C>T	uc003xqd.2	+	6	623	c.614C>T	c.(613-615)CCT>CTT	p.P205L	KIAA0146_uc011lcz.1_Intron|KIAA0146_uc011lda.1_Intron|KIAA0146_uc011ldb.1_Missense_Mutation_p.P205L|KIAA0146_uc010lxs.2_5'UTR|KIAA0146_uc011ldc.1_Missense_Mutation_p.P135L|KIAA0146_uc011ldd.1_Missense_Mutation_p.P145L|KIAA0146_uc003xqe.2_Intron|KIAA0146_uc003xqf.2_RNA|KIAA0146_uc011lde.1_Intron	NM_001080394	NP_001073863	Q14159	K0146_HUMAN	hypothetical protein LOC23514	205											0		Lung NSC(58;0.175)				TCAGAATCCCCTCACAAATAC	0.363		NaN											0	0	0	0.024245	0	14	87									
TRAM1	23471	broad.mit.edu	37	8	71520314	71520314	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr8:71520314C>G	uc003xyo.1	-	1	291	c.121G>C	c.(121-123)GAG>CAG	p.E41Q	TRAM1_uc011lfc.1_Missense_Mutation_p.E10Q	NM_014294	NP_055109	Q15629	TRAM1_HUMAN	translocation associated membrane protein 1	41	Helical; (Potential).				cotranslational protein targeting to membrane|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity			ovary(1)	1			Epithelial(68;0.00679)|all cancers(69;0.0324)|OV - Ovarian serous cystadenocarcinoma(28;0.0509)			GGGCTCACCTCAAACATGAGC	0.692		NaN											0	0	0	0.004672	0	3	33									
ZNF572	137209	broad.mit.edu	37	8	125987911	125987911	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr8:125987911C>T	uc003yrr.2	+	2	184	c.29C>T	c.(28-30)TCA>TTA	p.S10L		NM_152412	NP_689625	Q7Z3I7	ZN572_HUMAN	zinc finger protein 572	10					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			CTGTTGGTCTCAGATTCTAAC	0.378		NaN								HNSCC(60;0.17)			0	0	0	0.014323	0	16	117									
ZNF572	137209	broad.mit.edu	37	8	125988884	125988884	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr8:125988884C>T	uc003yrr.2	+	3	529	c.374C>T	c.(373-375)TCA>TTA	p.S125L		NM_152412	NP_689625	Q7Z3I7	ZN572_HUMAN	zinc finger protein 572	125					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			CAGCAGAATTCATCCTTTGTA	0.428		NaN								HNSCC(60;0.17)			0	0	0	0.020292	0	14	120									
ZNF572	137209	broad.mit.edu	37	8	125989705	125989705	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr8:125989705C>G	uc003yrr.2	+	3	1350	c.1195C>G	c.(1195-1197)CTC>GTC	p.L399V		NM_152412	NP_689625	Q7Z3I7	ZN572_HUMAN	zinc finger protein 572	399	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			TAGCTCCCATCTCATTAGACA	0.428		NaN								HNSCC(60;0.17)			0	0	0	0.008871	0	15	107									
EFR3A	23167	broad.mit.edu	37	8	132991207	132991207	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr8:132991207G>T	uc003yte.2	+	13	1641	c.1440G>T	c.(1438-1440)TTG>TTT	p.L480F		NM_015137	NP_055952	Q14156	EFR3A_HUMAN	EFR3 homolog A	480						plasma membrane	binding			ovary(3)|breast(1)|central_nervous_system(1)	5	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)|LUAD - Lung adenocarcinoma(14;0.102)			AGTTGGTCTTGGAAGTAATGC	0.418		NaN											1	0	3.65163e-15	0.030593	4.09831e-15	21	184									
PLEC	5339	broad.mit.edu	37	8	144991923	144991923	+	Silent	SNP	G	G	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr8:144991923G>T	uc003zaf.1	-	32	12647	c.12477C>A	c.(12475-12477)CTC>CTA	p.L4159L	PLEC_uc003zab.1_Silent_p.L4022L|PLEC_uc003zac.1_Silent_p.L4026L|PLEC_uc003zad.2_Silent_p.L4022L|PLEC_uc003zae.1_Silent_p.L3990L|PLEC_uc003zag.1_Silent_p.L4000L|PLEC_uc003zah.2_Silent_p.L4008L|PLEC_uc003zaj.2_Silent_p.L4049L	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	4159	Globular 2.|Plectin 24.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						AGAGGGAGATGAGCTTCCCAG	0.632		NaN											1	0	2.61681e-11	0.020292	2.91021e-11	12	54									
MFSD3	113655	broad.mit.edu	37	8	145736008	145736008	+	Silent	SNP	G	G	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr8:145736008G>T	uc003zdi.1	+	3	1023	c.858G>T	c.(856-858)GTG>GTT	p.V286V		NM_138431	NP_612440	Q96ES6	MFSD3_HUMAN	major facilitator superfamily domain containing	286	Leu-rich.				transmembrane transport	integral to membrane				central_nervous_system(2)	2	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			TGAGGTCGGTGCTGCGCTTCC	0.617		NaN											1	0	2.68985e-26	0.01441	3.07531e-26	36	190									
DMRT2	10655	broad.mit.edu	37	9	1057268	1057268	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr9:1057268C>T	uc003zha.2	+	4	1881	c.1681C>T	c.(1681-1683)CAG>TAG	p.Q561*	DMRT2_uc003zgx.3_Nonsense_Mutation_p.Q328*|DMRT2_uc010mgz.2_Nonsense_Mutation_p.Q328*|DMRT2_uc003zgy.3_Nonsense_Mutation_p.Q405*|DMRT2_uc003zhb.3_3'UTR|DMRT2_uc011llt.1_3'UTR|DMRT2_uc011llu.1_3'UTR|DMRT2_uc011llv.1_Nonsense_Mutation_p.Q561*	NM_181872	NP_870987	Q9Y5R5	DMRT2_HUMAN	doublesex and mab-3 related transcription factor	561					male gonad development|sex determination	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity				0		all_lung(10;1.49e-09)|Lung NSC(10;1.86e-09)		Lung(218;0.0195)|GBM - Glioblastoma multiforme(50;0.0388)		TCGTGTCTCTCAGTGAAAGGC	0.383		NaN											0	0	0	0.012319	0	18	112									
GLIS3	169792	broad.mit.edu	37	9	3898796	3898796	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr9:3898796C>G	uc003zhw.1	-	6	1752	c.1558G>C	c.(1558-1560)GAT>CAT	p.D520H	GLIS3_uc003zhx.1_Missense_Mutation_p.D675H|GLIS3_uc010mhf.1_Missense_Mutation_p.D69H|GLIS3_uc003zhv.1_RNA|GLIS3_uc003zhy.1_Missense_Mutation_p.D453H|GLIS3_uc003zhz.1_Missense_Mutation_p.D453H|C9orf70_uc003zia.2_RNA	NM_152629	NP_689842	Q8NEA6	GLIS3_HUMAN	GLIS family zinc finger 3 isoform b	520					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)		GTGAGGCAATCTGTGAGCAGG	0.587		NaN											0	0	0	0.010818	0	29	55									
KIAA1432	57589	broad.mit.edu	37	9	5746003	5746003	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr9:5746003G>A	uc003zji.2	+	10	1024	c.931G>A	c.(931-933)GAC>AAC	p.D311N	KIAA1432_uc003zjh.2_Missense_Mutation_p.D311N|KIAA1432_uc003zjl.3_Missense_Mutation_p.D311N|KIAA1432_uc003zjj.1_5'UTR	NM_020829	NP_065880	Q4ADV7	RIC1_HUMAN	connexin 43-interacting protein 150 isoform a	390						integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		AATTGAGTCTGACCTCAGGAG	0.408		NaN											0	0	0	0.024334	0	21	126									
IFNA16	3449	broad.mit.edu	37	9	21216778	21216778	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr9:21216778G>C	uc003zor.1	-	1	533	c.527C>G	c.(526-528)TCT>TGT	p.S176C	IFNA14_uc003zoo.1_Intron	NM_002173	NP_002164	P05015	IFN16_HUMAN	interferon, alpha 16 precursor	176					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			skin(1)	1				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		TGTTGAAAAAGAGAAGGATCT	0.373		NaN											0	0	0	0.01441	0	169	278									
LINGO2	158038	broad.mit.edu	37	9	27950351	27950351	+	Silent	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr9:27950351G>A	uc003zqu.1	-	2	513	c.319C>T	c.(319-321)CTG>TTG	p.L107L	LINGO2_uc010mjf.1_Silent_p.L107L|LINGO2_uc003zqv.1_Silent_p.L107L	NM_152570	NP_689783	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	107	LRR 3.|Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		AGGGAACGCAGGTTAAAGAGA	0.448		NaN											0	0	0	0.01441	0	78	121									
TAF1L	138474	broad.mit.edu	37	9	32632499	32632499	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr9:32632499G>A	uc003zrg.1	-	1	3169	c.3079C>T	c.(3079-3081)CGT>TGT	p.R1027C	uc003zrh.1_5'Flank	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	1027					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		CCAAATTTACGTAGAAGTTGC	0.473		NaN											0	0	0	0.01441	0	42	275									
TRPM6	140803	broad.mit.edu	37	9	77376712	77376712	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr9:77376712G>C	uc004ajl.1	-	27	4923	c.4685C>G	c.(4684-4686)TCT>TGT	p.S1562C	TRPM6_uc004ajk.1_Missense_Mutation_p.S1557C|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Intron|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajj.1_Missense_Mutation_p.S518C	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1562	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						TATTTCTGAAGAGCCTGAAAG	0.428		NaN											0	0	0	0.008871	0	15	43									
VPS13A	23230	broad.mit.edu	37	9	79898509	79898509	+	Silent	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr9:79898509C>T	uc004akr.2	+	31	3542	c.3282C>T	c.(3280-3282)AAC>AAT	p.N1094N	VPS13A_uc004akp.3_Silent_p.N1094N|VPS13A_uc004akq.3_Silent_p.N1094N|VPS13A_uc004aks.2_Silent_p.N1055N	NM_033305	NP_150648	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13A isoform A	1094					Golgi to endosome transport|protein transport	intracellular	protein binding			pancreas(3)|skin(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	10						CTGAAATAAACGCAAAGCTAA	0.284		NaN											0	0	0	0.014323	0	18	28									
TLE1	7088	broad.mit.edu	37	9	84230956	84230956	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr9:84230956G>C	uc004aly.2	-	11	1300	c.859C>G	c.(859-861)CCA>GCA	p.P287A	TLE1_uc004alz.2_Missense_Mutation_p.P297A|TLE1_uc011lsr.1_Missense_Mutation_p.P287A|TLE1_uc004ama.1_Missense_Mutation_p.P287A|TLE1_uc011lss.1_Missense_Mutation_p.P213A	NM_005077	NP_005068	Q04724	TLE1_HUMAN	transducin-like enhancer protein 1	287	Pro/Ser-rich.				negative regulation of Wnt receptor signaling pathway|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway		transcription factor binding			ovary(1)|skin(1)	2						GTGGAAGCTGGACTGCTAGAA	0.502		NaN											0	0	0	0.024245	0	15	75									
MRPL50	54534	broad.mit.edu	37	9	104153059	104153059	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr9:104153059G>C	uc004bbe.2	-	2	211	c.166C>G	c.(166-168)CGA>GGA	p.R56G	MRPL50_uc011lvj.1_Missense_Mutation_p.R56G	NM_019051	NP_061924	Q8N5N7	RM50_HUMAN	mitochondrial ribosomal protein L50	56						mitochondrion|ribosome					0		Acute lymphoblastic leukemia(62;0.0559)				GCTCGGCTTCGTAAAGGTGGA	0.408		NaN											0	0	0	0.021523	0	18	58									
OR13C5	138799	broad.mit.edu	37	9	107360932	107360932	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr9:107360932T>C	uc011lvp.1	-	1	763	c.763A>G	c.(763-765)ATC>GTC	p.I255V		NM_001004482	NP_001004482	Q8NGS8	O13C5_HUMAN	olfactory receptor, family 13, subfamily C,	255	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4						ATGAGGAAGATGGTCCCACAG	0.438		NaN											0	0	0	0.017118	0	30	49									
SRPX	8406	broad.mit.edu	37	X	38019289	38019289	+	Silent	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chrX:38019289G>A	uc004ddy.1	-	7	1022	c.936C>T	c.(934-936)GGC>GGT	p.G312G	SRPX_uc004ddz.1_Silent_p.G292G|SRPX_uc011mkh.1_Silent_p.G253G|SRPX_uc011mki.1_Silent_p.G312G	NM_006307	NP_006298	P78539	SRPX_HUMAN	sushi-repeat-containing protein, X-linked	312	Sushi 3.				cell adhesion	cell surface|membrane					0						TGGGCTCCGTGCCAGACCAAG	0.567		NaN											0	0	0	0.014758	0	4	7									
SMC1A	8243	broad.mit.edu	37	X	53438989	53438989	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chrX:53438989C>T	uc004dsg.2	-	6	1138	c.1069G>A	c.(1069-1071)GAG>AAG	p.E357K	SMC1A_uc011moe.1_Missense_Mutation_p.E335K|SMC1A_uc011mof.1_Intron	NM_006306	NP_006297	Q14683	SMC1A_HUMAN	structural maintenance of chromosomes 1A	357	Potential.				cell cycle checkpoint|cell division|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic sister chromatid cohesion|mitotic spindle organization|negative regulation of DNA endoreduplication|nuclear mRNA splicing, via spliceosome|response to radiation|signal transduction in response to DNA damage	cohesin core heterodimer|condensed chromosome kinetochore|condensed nuclear chromosome|cytoplasm|meiotic cohesin complex|nucleoplasm	ATP binding|chromatin binding|microtubule motor activity|protein heterodimerization activity			ovary(5)|central_nervous_system(1)	6						CTCTGACTCTCTTCTTCCATC	0.527		NaN											0	0	0	0.009096	0	4	6									
USP51	158880	broad.mit.edu	37	X	55514287	55514287	+	Silent	SNP	C	C	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chrX:55514287C>G	uc004dun.1	-	2	1165	c.1086G>C	c.(1084-1086)CTG>CTC	p.L362L	USP51_uc011moo.1_Silent_p.L66L	NM_201286	NP_958443	Q70EK9	UBP51_HUMAN	ubiquitin specific protease 51	362					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3						TTAGCCCTCTCAGGCCTACAG	0.403		NaN											0	0	0	0.014323	0	20	32									
PHKA1	5255	broad.mit.edu	37	X	71840611	71840611	+	Missense_Mutation	SNP	A	A	C			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chrX:71840611A>C	uc004eax.3	-	19	2402	c.2101T>G	c.(2101-2103)TCC>GCC	p.S701A	PHKA1_uc004eay.3_Missense_Mutation_p.S701A|PHKA1_uc011mqi.1_Intron	NM_002637	NP_002628	P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle) isoform	701					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(3)|skin(1)	4	Renal(35;0.156)					GTCACCAAGGACATTAAGTCG	0.552		NaN											0	0	0	0.021553	0	5	38									
L1CAM	3897	broad.mit.edu	37	X	153131202	153131202	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chrX:153131202G>A	uc004fjb.2	-	19	2612	c.2504C>T	c.(2503-2505)CCG>CTG	p.P835L	L1CAM_uc004fjc.2_Missense_Mutation_p.P835L|L1CAM_uc010nuo.2_Missense_Mutation_p.P830L	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	835	Extracellular (Potential).|Fibronectin type-III 3.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CAGGTCCACCGGCCGCCACTT	0.587		NaN											0	0	0	0.01441	0	35	98									
DNASE1L1	1774	broad.mit.edu	37	X	153631496	153631496	+	Silent	SNP	G	G	A			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chrX:153631496G>A	uc004fks.1	-	7	752	c.561C>T	c.(559-561)TGC>TGT	p.C187C	RPL10_uc004fkq.1_Intron|RPL10_uc004fkr.1_Intron|DNASE1L1_uc004fkt.1_Silent_p.C187C|DNASE1L1_uc004fku.1_Silent_p.C187C|DNASE1L1_uc004fkv.1_Silent_p.C187C|DNASE1L1_uc004fkw.1_Silent_p.C187C	NM_006730	NP_006721	P49184	DNSL1_HUMAN	deoxyribonuclease I-like 1 precursor	187					DNA catabolic process	endoplasmic reticulum	DNA binding|endodeoxyribonuclease activity, producing 5'-phosphomonoesters				0	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TCAGTGAAGCGCAGTCAGCAT	0.602		NaN											0	0	0	0.021553	0	5	84									
CCAR1	55749	broad.mit.edu	37	10	70509285	70509286	+	Frame_Shift_Del	DEL	GA	GA	-			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr10:70509285_70509286delGA	uc001joo.2	+	10	1080_1081	c.961_962delGA	c.(961-963)GAGfs	p.E321fs	CCAR1_uc001jol.1_RNA|CCAR1_uc001jom.1_Frame_Shift_Del_p.E126fs|CCAR1_uc009xpx.1_Frame_Shift_Del_p.E295fs|CCAR1_uc001jon.1_Frame_Shift_Del_p.E267fs|CCAR1_uc010qiz.1_Frame_Shift_Del_p.E306fs|CCAR1_uc010qja.1_Frame_Shift_Del_p.E306fs|CCAR1_uc010qjb.1_RNA	NM_018237	NP_060707	Q8IX12	CCAR1_HUMAN	cell-cycle and apoptosis regulatory protein 1	321	Arg-rich.				apoptosis|cell cycle|nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm|perinuclear region of cytoplasm	calcium ion binding|nucleic acid binding|protein binding			ovary(6)|large_intestine(1)	7						TTTCAGTCGTGAGAGAGAGAGA	0.391		NaN											NaN	NaN	NaN	NaN	NaN	8	65	---	---							
PLAU	5328	broad.mit.edu	37	10	75673458	75673459	+	Frame_Shift_Del	DEL	GT	GT	-			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr10:75673458_75673459delGT	uc001jwa.2	+	7	768_769	c.622_623delGT	c.(622-624)GTGfs	p.V208fs	C10orf55_uc001jvz.1_Intron|PLAU_uc010qkw.1_Frame_Shift_Del_p.V191fs|PLAU_uc010qkx.1_Frame_Shift_Del_p.V122fs|PLAU_uc001jwb.2_RNA|PLAU_uc001jwc.2_Frame_Shift_Del_p.V208fs|PLAU_uc009xrq.1_Frame_Shift_Del_p.V172fs	NM_002658	NP_002649	P00749	UROK_HUMAN	plasminogen activator, urokinase isoform 1	208	Peptidase S1.				blood coagulation|chemotaxis|fibrinolysis|proteolysis|regulation of cell adhesion mediated by integrin|regulation of receptor activity|regulation of smooth muscle cell migration|regulation of smooth muscle cell-matrix adhesion|signal transduction	cell surface|extracellular space|plasma membrane	serine-type endopeptidase activity			ovary(2)|kidney(1)	3	Prostate(51;0.0112)				Amiloride(DB00594)|Urokinase(DB00013)	TGTCACCTACGTGTGTGGAGGC	0.599		NaN											NaN	NaN	NaN	NaN	NaN	202	79	---	---							
TSKU	25987	broad.mit.edu	37	11	76506673	76506675	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:76506673_76506675delCTG	uc001oxt.2	+	2	185_187	c.13_15delCTG	c.(13-15)CTGdel	p.L9del		NM_015516	NP_056331	Q8WUA8	TSK_HUMAN	tsukushin precursor	9						extracellular region					0	Ovarian(111;0.112)					GCCGTGGCCCCTGCTGCTGCTGC	0.616		NaN											NaN	NaN	NaN	NaN	NaN	9	108	---	---							
MLL	4297	broad.mit.edu	37	11	118374297	118374298	+	Frame_Shift_Ins	INS	-	-	CCTC			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08			-	CCTC	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:118374297_118374298insCCTC	uc001pta.2	+	27	7704_7705	c.7681_7682insCCTC	c.(7681-7683)GCCfs	p.A2561fs	MLL_uc001ptb.2_Frame_Shift_Ins_p.A2564fs	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	2561					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		ACCAATTTCAGCCTCTGAAAAT	0.431		NaN	T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								NaN	NaN	NaN	NaN	NaN	20	60	---	---							
DNM1L	10059	broad.mit.edu	37	12	32861134	32861135	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:32861134_32861135delAG	uc001rld.2	+	4	506_507	c.345_346delAG	c.(343-348)ACAGAAfs	p.T115fs	DNM1L_uc010skf.1_RNA|DNM1L_uc010skg.1_RNA|DNM1L_uc001rle.2_Frame_Shift_Del_p.T115fs|DNM1L_uc001rlf.2_Frame_Shift_Del_p.T115fs|DNM1L_uc010skh.1_Frame_Shift_Del_p.T181fs|DNM1L_uc001rlg.2_Frame_Shift_Del_p.T181fs|DNM1L_uc001rlh.2_Frame_Shift_Del_p.T168fs|DNM1L_uc010ski.1_Intron	NM_012062	NP_036192	O00429	DNM1L_HUMAN	dynamin 1-like isoform 1	115_116	GTPase domain.				cellular component disassembly involved in apoptosis|mitochondrial fragmentation involved in apoptosis|mitochondrial membrane organization|positive regulation of mitochondrial fission	cis-Golgi network|cytosol|endomembrane system|endoplasmic reticulum|mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2	Lung NSC(5;2.15e-06)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					AAAATGAAACAGAAAGAATTTC	0.262		NaN											NaN	NaN	NaN	NaN	NaN	45	49	---	---							
ASCL1	429	broad.mit.edu	37	12	103352172	103352174	+	In_Frame_Del	DEL	GCA	GCA	-	rs72405287		TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:103352172_103352174delGCA	uc001tjr.3	+	1	721_723	c.150_152delGCA	c.(148-153)GCGCAG>GCG	p.Q62del		NM_004316	NP_004307	P50553	ASCL1_HUMAN	achaete-scute complex homolog 1	62	Poly-Gln.			Q -> QQQ (in Ref. 1).	cerebral cortex GABAergic interneuron differentiation|negative regulation of apoptosis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|noradrenergic neuron fate commitment|Notch signaling pathway|positive regulation of neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|response to retinoic acid|sympathetic nervous system development	nucleus	bHLH transcription factor binding|E-box binding|sequence-specific DNA binding transcription factor activity|transcription factor binding transcription factor activity				0						cgcagagcgcgcagcagcagcag	0.443		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---	---							
BEGAIN	57596	broad.mit.edu	37	14	101005271	101005273	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr14:101005271_101005273delCCT	uc010txa.1	-	6	961_963	c.815_817delAGG	c.(814-819)GAGGCC>GCC	p.E272del	BEGAIN_uc001yhp.2_In_Frame_Del_p.E208del|BEGAIN_uc001yhq.2_In_Frame_Del_p.E272del	NM_001159531	NP_001153003	Q9BUH8	BEGIN_HUMAN	brain-enriched guanylate kinase-associated	272						cytoplasm|membrane	protein binding				0		Melanoma(154;0.212)				GCCGCCTCGGCCTCCTCCTCCTC	0.724		NaN											NaN	NaN	NaN	NaN	NaN	7	18	---	---							
MMP28	79148	broad.mit.edu	37	17	34093889	34093889	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:34093889delC	uc002hjy.1	-	10	1452	c.1193delG	c.(1192-1194)GGCfs	p.G398fs	MMP28_uc002hjw.1_RNA|MMP28_uc002hjz.1_RNA	NM_024302	NP_077278	Q9H239	MMP28_HUMAN	matrix metalloproteinase 28 isoform 1	398	Hemopexin-like 2.				proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		TGGCTTGGGGCCCCGGAACCT	0.682		NaN									OREG0024329	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	NaN	NaN	NaN	NaN	NaN	2	4	---	---							
ZXDC	79364	broad.mit.edu	37	3	126178522	126178522	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr3:126178522delT	uc003eiv.2	-	7	2240	c.2186delA	c.(2185-2187)AAGfs	p.K729fs	ZXDC_uc010hsh.2_Intron|ZXDC_uc003eix.2_3'UTR	NM_025112	NP_079388	Q2QGD7	ZXDC_HUMAN	ZXD family zinc finger C isoform 1	729					positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|LRR domain binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.155)		TCCTCTCTGCTTTTTTTCCTT	0.522		NaN											NaN	NaN	NaN	NaN	NaN	10	890	---	---							
PCDHA11	56138	broad.mit.edu	37	5	140249748	140249748	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr5:140249748delT	uc003lia.2	+	1	1918	c.1060delT	c.(1060-1062)TTGfs	p.L354fs	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Frame_Shift_Del_p.L354fs	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	354	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTGACTTCCTTGTCCCTCCC	0.572		NaN											NaN	NaN	NaN	NaN	NaN	43	66	---	---							
PSPH	5723	broad.mit.edu	37	7	56087292	56087292	+	Splice_Site	DEL	C	C	-			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:56087292delC	uc003trg.2	-	4	638	c.275_splice	c.e4+1	p.R92_splice	PSPH_uc003trh.2_Splice_Site_p.R92_splice|PSPH_uc003tri.2_Splice_Site_p.R92_splice|PSPH_uc003trj.2_Splice_Site_p.R121_splice	NM_004577	NP_004568	P78330	SERB_HUMAN	phosphoserine phosphatase						L-serine biosynthetic process	cytoplasm	calcium ion binding|magnesium ion binding|phosphoserine phosphatase activity|protein homodimerization activity			ovary(1)|skin(1)	2	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			GTTCCTCTTACCTTATGCCGG	0.577		NaN											NaN	NaN	NaN	NaN	NaN	9	98	---	---							
ZNF777	27153	broad.mit.edu	37	7	149128965	149128966	+	Frame_Shift_Del	DEL	GC	GC	-			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:149128965_149128966delGC	uc003wfv.2	-	6	2560_2561	c.2397_2398delGC	c.(2395-2400)GCGCACfs	p.A799fs		NM_015694	NP_056509	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	Error:Variant_position_missing_in_Q9ULD5_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			TCGCCCGTGTGCGCGCGCTGGT	0.668		NaN											NaN	NaN	NaN	NaN	NaN	8	43	---	---							
ITIH5L	347365	broad.mit.edu	37	X	54824559	54824560	+	Frame_Shift_Ins	INS	-	-	G			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chrX:54824559_54824560insG	uc004dtj.2	-	1	114_115	c.84_85insC	c.(82-87)CCCGCTfs	p.P28fs		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	28_29	VIT.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						CTTGATGAAGCGGGGACAGGGG	0.48		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---	---