Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
PRKCZ	5590	broad.mit.edu	37	1	2077537	2077537	+	Missense_Mutation	SNP	G	G	C	rs143367104		TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr1:2077537G>C	uc001aiq.2	+	7	785	c.624G>C	c.(622-624)GAG>GAC	p.E208D	PRKCZ_uc001air.2_Missense_Mutation_p.E25D|PRKCZ_uc010nyw.1_Missense_Mutation_p.E104D|PRKCZ_uc001ais.2_Missense_Mutation_p.E25D|PRKCZ_uc009vla.2_Missense_Mutation_p.E32D|PRKCZ_uc010nyx.1_RNA|PRKCZ_uc009vlb.2_Missense_Mutation_p.E21D	NM_002744	NP_002735	Q05513	KPCZ_HUMAN	protein kinase C, zeta isoform 1	208					anti-apoptosis|intracellular signal transduction|negative regulation of insulin receptor signaling pathway|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein complex assembly|peptidyl-serine phosphorylation|platelet activation	endosome	ATP binding|protein kinase C activity|zinc ion binding			central_nervous_system(4)|large_intestine(2)	6	all_cancers(77;0.000177)|all_epithelial(69;6.41e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;1.14e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.96e-37)|OV - Ovarian serous cystadenocarcinoma(86;3.3e-23)|GBM - Glioblastoma multiforme(42;2.85e-08)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00294)|BRCA - Breast invasive adenocarcinoma(365;0.00493)|STAD - Stomach adenocarcinoma(132;0.00669)|KIRC - Kidney renal clear cell carcinoma(229;0.0411)|Lung(427;0.213)		CTTCCGAGGAGACAGATGGAA	0.582		NaN											0	0	0	6.4e-05	0	3	51									
DFFA	1676	broad.mit.edu	37	1	10527261	10527261	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr1:10527261C>T	uc001arj.2	-	3	525	c.427G>A	c.(427-429)GAG>AAG	p.E143K	DFFA_uc001ark.2_Missense_Mutation_p.E143K	NM_004401	NP_004392	O00273	DFFA_HUMAN	DNA fragmentation factor, 45kDa, alpha	143					DNA fragmentation involved in apoptotic nuclear change|intracellular signal transduction|negative regulation of apoptosis	cytosol|mitochondrion|nucleoplasm|plasma membrane	deoxyribonuclease activity|identical protein binding				0	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.25e-07)|COAD - Colon adenocarcinoma(227;7.25e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000296)|Kidney(185;0.00074)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0487)		AGGTCCTCCTCTGATAGGAGG	0.532		NaN											0	0	0	0.000175454	0	19	114									
EPB41	2035	broad.mit.edu	37	1	29379626	29379626	+	Silent	SNP	C	C	A	rs145888614	byFrequency	TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr1:29379626C>A	uc001brm.1	+	11	1654	c.1647C>A	c.(1645-1647)GTC>GTA	p.V549V	EPB41_uc001brg.1_Silent_p.V340V|EPB41_uc001brh.1_Silent_p.V340V|EPB41_uc001bri.1_Silent_p.V514V|EPB41_uc001brj.1_Silent_p.V340V|EPB41_uc009vtk.1_Silent_p.V513V|EPB41_uc001brk.2_Silent_p.V549V|EPB41_uc001brl.1_Silent_p.V549V|EPB41_uc009vtl.1_Silent_p.V340V|EPB41_uc009vtm.1_Silent_p.V182V	NM_203342	NP_976217	P11171	41_HUMAN	erythrocyte membrane protein band 4.1	549	Hydrophilic.				blood circulation|cortical actin cytoskeleton organization|positive regulation of protein binding	extrinsic to membrane|Golgi apparatus|nucleus|plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	1-phosphatidylinositol binding|actin binding|spectrin binding|structural constituent of cytoskeleton			ovary(1)	1		Colorectal(325;3.46e-05)|Prostate(1639;0.000244)|Lung NSC(340;0.00328)|all_lung(284;0.00412)|Breast(348;0.00765)|all_neural(195;0.0199)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)|Medulloblastoma(700;0.123)		Colorectal(126;3.12e-07)|COAD - Colon adenocarcinoma(152;1.21e-05)|STAD - Stomach adenocarcinoma(196;0.00395)|KIRC - Kidney renal clear cell carcinoma(1967;0.0249)|BRCA - Breast invasive adenocarcinoma(304;0.0289)|READ - Rectum adenocarcinoma(331;0.0757)		CAGCAGCTGTCGATTCGGCAG	0.483		NaN											1	0	5.50884e-06	0.00010058	6.41337e-05	10	32									
S100PBP	64766	broad.mit.edu	37	1	33292110	33292110	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr1:33292110C>G	uc001bvz.2	+	3	687	c.410C>G	c.(409-411)TCT>TGT	p.S137C	S100PBP_uc001bwa.1_Missense_Mutation_p.S137C|S100PBP_uc001bwb.1_Missense_Mutation_p.S137C|S100PBP_uc001bwc.2_Missense_Mutation_p.S137C|S100PBP_uc001bwd.2_RNA	NM_022753	NP_073590	Q96BU1	S1PBP_HUMAN	S100P binding protein isoform a	137						nucleus	calcium-dependent protein binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				AACAGACGCTCTGTACTAGAA	0.418		NaN											0	0	0	8.12818e-05	0	5	31									
ERI3	79033	broad.mit.edu	37	1	44804820	44804820	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr1:44804820C>T	uc001clt.2	-	3	627	c.386G>A	c.(385-387)GGC>GAC	p.G129D	ERI3_uc010okv.1_Intron|ERI3_uc009vxg.2_Missense_Mutation_p.G129D|ERI3_uc010okw.1_Missense_Mutation_p.G51D|ERI3_uc001clu.2_Missense_Mutation_p.G51D	NM_024066	NP_076971	O43414	ERI3_HUMAN	prion protein interacting protein	129						intracellular	exonuclease activity|metal ion binding|nucleic acid binding			ovary(2)|large_intestine(1)	3						CATGGATGCGCCAAAGCCGTG	0.542		NaN											0	0	0	0.000308642	0	15	187									
GBP5	115362	broad.mit.edu	37	1	89729593	89729593	+	Silent	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr1:89729593C>T	uc001dnc.2	-	9	1725	c.1188G>A	c.(1186-1188)CGG>CGA	p.R396R	GBP5_uc001dnd.2_Silent_p.R396R|GBP5_uc001dne.1_Silent_p.R396R	NM_052942	NP_443174	Q96PP8	GBP5_HUMAN	guanylate-binding protein 5	396						plasma membrane	GTP binding|GTPase activity			ovary(1)	1				all cancers(265;0.00784)|Epithelial(280;0.0286)		CTTCCAGGTTCCGTTTACAAA	0.383		NaN											0	0	0	0.000308642	0	15	122									
S1PR1	1901	broad.mit.edu	37	1	101705363	101705363	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr1:101705363C>G	uc001dud.2	+	2	1337	c.823C>G	c.(823-825)CTG>GTG	p.L275V	S1PR1_uc009weg.2_Missense_Mutation_p.L275V	NM_001400	NP_001391	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	275	Helical; Name=6; (By similarity).				cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity			ovary(2)|lung(1)	3						GCTCTTCATCCTGCTCCTGCT	0.582		NaN											0	0	0	0.000319135	0	38	244									
CTTNBP2NL	55917	broad.mit.edu	37	1	112998771	112998771	+	Silent	SNP	A	A	G			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr1:112998771A>G	uc001ebx.2	+	6	885	c.657A>G	c.(655-657)GAA>GAG	p.E219E	CTTNBP2NL_uc001ebz.2_5'Flank	NM_018704	NP_061174	Q9P2B4	CT2NL_HUMAN	CTTNBP2 N-terminal like	219	Potential.					actin cytoskeleton	protein binding			central_nervous_system(2)|ovary(1)	3		all_cancers(81;0.00064)|all_epithelial(167;0.000415)|all_lung(203;0.00045)|Lung NSC(69;0.000705)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		AACTGGAAGAAGAGTTGGCAG	0.512		NaN											0	0	0	0.000442599	0	9	59									
PDE4DIP	9659	broad.mit.edu	37	1	144859924	144859924	+	Silent	SNP	G	G	A			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr1:144859924G>A	uc001elw.3	-	38	6451	c.6160C>T	c.(6160-6162)CTG>TTG	p.L2054L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Silent_p.L1948L|PDE4DIP_uc001elv.3_Silent_p.L1061L	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	2054	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TGCCCTCTCAGAGCTCGTACC	0.577		NaN	T	PDGFRB	MPD								0	0	0	0.000274275	0	9	100									
FLG	2312	broad.mit.edu	37	1	152284039	152284039	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr1:152284039C>T	uc001ezu.1	-	3	3359	c.3323G>A	c.(3322-3324)GGG>GAG	p.G1108E	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1108	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGACCTTCCCCCTGACCAGTC	0.582		NaN							Ichthyosis				0	0	0	0.000781405	0	57	258									
CRTC2	200186	broad.mit.edu	37	1	153921053	153921053	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr1:153921053C>G	uc010ped.1	-	13	1812	c.1742G>C	c.(1741-1743)GGG>GCG	p.G581A	DENND4B_uc001fdd.1_5'Flank|CRTC2_uc001fde.3_RNA|CRTC2_uc001fdf.3_Missense_Mutation_p.G117A	NM_181715	NP_859066	Q53ET0	CRTC2_HUMAN	CREB regulated transcription coactivator 2	581					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)	2	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			AAATCCAGGCCCTTCAGAAAA	0.567		NaN											0	0	0	0.000274275	0	8	109									
CRTC2	200186	broad.mit.edu	37	1	153921067	153921067	+	Silent	SNP	A	A	G			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr1:153921067A>G	uc010ped.1	-	13	1798	c.1728T>C	c.(1726-1728)CCT>CCC	p.P576P	DENND4B_uc001fdd.1_5'Flank|CRTC2_uc001fde.3_RNA|CRTC2_uc001fdf.3_Silent_p.P112P	NM_181715	NP_859066	Q53ET0	CRTC2_HUMAN	CREB regulated transcription coactivator 2	576					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)	2	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CAGAAAAGCCAGGGGGATCCA	0.542		NaN											0	0	0	0.000673444	0	10	108									
GON4L	54856	broad.mit.edu	37	1	155721969	155721969	+	Silent	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr1:155721969C>T	uc001flz.2	-	30	6352	c.6255G>A	c.(6253-6255)GTG>GTA	p.V2085V	GON4L_uc001flx.1_5'Flank|GON4L_uc009wrg.1_RNA|GON4L_uc001fly.1_Silent_p.V2084V|GON4L_uc009wrh.1_Silent_p.V2084V|GON4L_uc001fma.1_Silent_p.V2085V	NM_001037533	NP_001032622	Q3T8J9	GON4L_HUMAN	gon-4-like isoform a	2085					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(3)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					CTCTTGTCTTCACCCGAGCTC	0.527		NaN											0	0	0	0.000308642	0	16	141									
LAMB3	3914	broad.mit.edu	37	1	209799289	209799289	+	Silent	SNP	G	G	C			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr1:209799289G>C	uc001hhg.2	-	13	2070	c.1680C>G	c.(1678-1680)ACC>ACG	p.T560T	LAMB3_uc009xco.2_Silent_p.T560T|LAMB3_uc001hhh.2_Silent_p.T560T|LAMB3_uc010psl.1_Intron|hsa-mir-4260|MI0015859_5'Flank	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	560	Laminin EGF-like 6.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|skin(2)|large_intestine(1)|ovary(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		AGCGGGGCCCGGTCAAGCCAG	0.647		NaN											0	0	0	0.000602214	0	5	57									
SPATA17	128153	broad.mit.edu	37	1	217915425	217915425	+	Silent	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr1:217915425C>T	uc001hlh.1	+	6	530	c.504C>T	c.(502-504)CTC>CTT	p.L168L	SPATA17_uc009xdr.1_RNA|SPATA17_uc001hli.2_Silent_p.L168L	NM_138796	NP_620151	Q96L03	SPT17_HUMAN	spermatogenesis associated 17	168						cytoplasm	calmodulin binding			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0516)|all cancers(67;0.0891)|GBM - Glioblastoma multiforme(131;0.117)		TGCATTACCTCCTCAGCACAA	0.473		NaN											0	0	0	8.12818e-05	0	7	85									
CDC42BPA	8476	broad.mit.edu	37	1	227316871	227316871	+	Silent	SNP	G	G	A			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr1:227316871G>A	uc001hqr.2	-	11	2395	c.1452C>T	c.(1450-1452)AGC>AGT	p.S484S	CDC42BPA_uc001hqs.2_Silent_p.S484S|CDC42BPA_uc009xes.2_Silent_p.S484S|CDC42BPA_uc010pvs.1_Silent_p.S484S	NM_003607	NP_003598	Q5VT25	MRCKA_HUMAN	CDC42-binding protein kinase alpha isoform B	484	Potential.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(6)|breast(2)|stomach(1)|ovary(1)|pancreas(1)	11		all_cancers(173;0.156)|Prostate(94;0.0792)				CTAAATCTTTGCTTGCTGTTA	0.289		NaN											0	0	0	0.000157383	0	7	62									
PLD5	200150	broad.mit.edu	37	1	242253336	242253336	+	Silent	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr1:242253336C>T	uc001hzn.1	-	10	1558	c.1431G>A	c.(1429-1431)AGG>AGA	p.R477R	PLD5_uc001hzl.3_Silent_p.R415R|PLD5_uc001hzm.3_Silent_p.R267R|PLD5_uc001hzo.1_Silent_p.R385R			Q8N7P1	PLD5_HUMAN	RecName: Full=Inactive phospholipase D5;          Short=Inactive PLD 5; AltName: Full=Inactive choline phosphatase 5; AltName: Full=Inactive phosphatidylcholine-hydrolyzing phospholipase D5; AltName: Full=PLDc;	477						integral to membrane	catalytic activity			ovary(6)	6	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			TTCTGTTGTTCCTCACATCTG	0.423		NaN											0	0	0	8.12818e-05	0	6	98									
OR2M2	391194	broad.mit.edu	37	1	248344190	248344190	+	Silent	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr1:248344190C>T	uc010pzf.1	+	1	903	c.903C>T	c.(901-903)TTC>TTT	p.F301F		NM_001004688	NP_001004688	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M,	301	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CTAGAGCATTCATGAAGATCT	0.423		NaN											0	0	0	0.000175454	0	21	105									
FAM171A1	221061	broad.mit.edu	37	10	15255261	15255261	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr10:15255261C>T	uc001iob.2	-	8	2333	c.2326G>A	c.(2326-2328)GAG>AAG	p.E776K		NM_001010924	NP_001010924	Q5VUB5	F1711_HUMAN	hypothetical protein LOC221061 precursor	776	Cytoplasmic (Potential).					integral to membrane				ovary(2)|breast(1)|skin(1)	4						GCTCGAGGCTCTTTCTGCTGG	0.577		NaN											0	0	0	0.000308642	0	13	64									
C10orf140	387640	broad.mit.edu	37	10	21805233	21805233	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr10:21805233C>T	uc009xkd.2	-	4	3772	c.1519G>A	c.(1519-1521)GAC>AAC	p.D507N	uc001iqp.1_RNA	NM_207371	NP_997254	Q1XH10	DLN1_HUMAN	hypothetical protein LOC387640	426						nucleus	nucleotide binding			ovary(1)	1						CTCTTGAGGTCGGGAAGTCTG	0.652		NaN											0	0	0	0.000422831	0	17	93									
PIP4K2A	5305	broad.mit.edu	37	10	22828982	22828982	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr10:22828982T>A	uc001irl.3	-	9	1306	c.1058A>T	c.(1057-1059)TAC>TTC	p.Y353F	PIP4K2A_uc010qcu.1_Missense_Mutation_p.Y213F	NM_005028	NP_005019	P48426	PI42A_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	353	PIPK.						1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding			ovary(1)|skin(1)	2						TGCCATGAAGTACACCTCCTT	0.478		NaN											0	0	0	0.000191422	0	37	91									
CPEB3	22849	broad.mit.edu	37	10	93952323	93952323	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr10:93952323G>C	uc001khw.1	-	3	1249	c.1076C>G	c.(1075-1077)ACT>AGT	p.T359S	CPEB3_uc001khu.1_Missense_Mutation_p.T359S|CPEB3_uc001khv.1_Missense_Mutation_p.T359S|CPEB3_uc010qnn.1_Missense_Mutation_p.T359S	NM_014912	NP_055727	Q8NE35	CPEB3_HUMAN	cytoplasmic polyadenylation element binding	359							nucleotide binding|RNA binding				0		Colorectal(252;0.0869)				TTCATGATCAGTCCTTATCAT	0.403		NaN											0	0	0	3.59834e-05	0	6	19									
RAG2	5897	broad.mit.edu	37	11	36615460	36615460	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr11:36615460C>G	uc001mwv.3	-	2	447	c.259G>C	c.(259-261)GAA>CAA	p.E87Q	C11orf74_uc010rfd.1_5'Flank|C11orf74_uc001mww.1_5'Flank|C11orf74_uc001mwx.1_5'Flank|C11orf74_uc001mwy.1_5'Flank|C11orf74_uc001mwz.1_5'Flank|C11orf74_uc010rfe.1_5'Flank	NM_000536	NP_000527	P55895	RAG2_HUMAN	recombination activating gene 2	87					chromatin modification|pre-B cell allelic exclusion|somatic diversification of immunoglobulins|T cell differentiation in thymus|V(D)J recombination	nucleus	chromatin binding|DNA binding|endonuclease activity|methylated histone residue binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|zinc ion binding			skin(3)|ovary(1)|pancreas(1)	5	all_lung(20;0.226)	all_hematologic(20;0.00756)				TGATGCTTTTCAGACTCCAAG	0.418		NaN							Familial_Hemophagocytic_Lymphohistiocytosis				0	0	0	0.000175454	0	20	366									
EXT2	2132	broad.mit.edu	37	11	44135765	44135765	+	Silent	SNP	G	G	C			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr11:44135765G>C	uc001mxz.2	+	4	991	c.657G>C	c.(655-657)ACG>ACC	p.T219T	EXT2_uc010rfo.1_Silent_p.T247T|EXT2_uc001mxy.2_Silent_p.T232T|EXT2_uc009ykt.2_Silent_p.T219T|EXT2_uc001mya.2_Silent_p.T252T	NM_207122	NP_997005	Q93063	EXT2_HUMAN	exostosin 2 isoform 2	219	Lumenal (Potential).				glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction	Golgi membrane|integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity			lung(2)|breast(2)|skin(1)	5						GCTTTTCTACGTGGACTTACC	0.473		NaN	Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses				0	0	0	8.12818e-05	0	7	94									
OR4A47	403253	broad.mit.edu	37	11	48511224	48511224	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr11:48511224A>G	uc010rhx.1	+	1	880	c.880A>G	c.(880-882)AGT>GGT	p.S294G		NM_001005512	NP_001005512	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A,	294	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TGAGATGACAAGTGCTATGAA	0.418		NaN											0	0	0	6.4e-05	0	3	56									
OR8J1	219477	broad.mit.edu	37	11	56128191	56128191	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr11:56128191A>G	uc010rjh.1	+	1	469	c.469A>G	c.(469-471)ATT>GTT	p.I157V		NM_001005205	NP_001005205	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J,	157	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					TTCTACAGCTATTGTGGTTTC	0.423		NaN											0	0	0	0.00024832	0	4	36									
STX3	6809	broad.mit.edu	37	11	59554605	59554605	+	Missense_Mutation	SNP	G	G	C	rs140824363		TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr11:59554605G>C	uc001nog.2	+	3	400	c.210G>C	c.(208-210)GAG>GAC	p.E70D	STX3_uc010rkx.1_Missense_Mutation_p.E70D|STX3_uc010rky.1_Intron|STX3_uc009ymt.1_5'UTR	NM_004177	NP_004168	Q13277	STX3_HUMAN	syntaxin 3	70	Cytoplasmic (Potential).|Potential.				cellular response to oxidative stress|intracellular protein transport|neuron projection development|neurotransmitter transport	apical plasma membrane|azurophil granule|cell-cell junction|growth cone|integral to membrane|plasma membrane enriched fraction|SNARE complex|specific granule	arachidonic acid binding|SNAP receptor activity			ovary(2)	2						CGATTCCAGAGCCAAGTGAGT	0.448		NaN											0	0	0	8.12818e-05	0	6	43									
LTBP3	4054	broad.mit.edu	37	11	65308027	65308027	+	Silent	SNP	G	G	A			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr11:65308027G>A	uc001oej.2	-	22	3305	c.3036C>T	c.(3034-3036)AAC>AAT	p.N1012N	LTBP3_uc001oef.2_Silent_p.N15N|LTBP3_uc001oeg.2_Silent_p.N15N|LTBP3_uc001oeh.2_Silent_p.N442N|LTBP3_uc010roi.1_Silent_p.N895N|LTBP3_uc001oei.2_Silent_p.N1012N|LTBP3_uc010roj.1_Silent_p.N713N|LTBP3_uc010rok.1_Silent_p.N923N	NM_001130144	NP_001123616	Q9NS15	LTBP3_HUMAN	latent transforming growth factor beta binding	1012	EGF-like 10; calcium-binding (Potential).					extracellular region	calcium ion binding|growth factor binding			central_nervous_system(2)|lung(1)	3						CAGGCTGCGTGTTCACGCACT	0.642		NaN									OREG0021080	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000295444	0	22	131									
ARHGEF17	9828	broad.mit.edu	37	11	73073578	73073578	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr11:73073578C>T	uc001otu.2	+	14	4816	c.4795C>T	c.(4795-4797)CTC>TTC	p.L1599F		NM_014786	NP_055601	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1599					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity				0						AGCCGCGACGCTCGCGGAGCC	0.731		NaN											0	0	0	8.12818e-05	0	5	32									
HEPHL1	341208	broad.mit.edu	37	11	93796804	93796804	+	Silent	SNP	G	G	C			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr11:93796804G>C	uc001pep.2	+	3	703	c.546G>C	c.(544-546)CTG>CTC	p.L182L		NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1 precursor	182	Plastocyanin-like 1.|Extracellular (Potential).				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				CCAACTGCCTGACCTGGGTGT	0.532		NaN											0	0	0	0.000602214	0	5	47									
SESN3	143686	broad.mit.edu	37	11	94911061	94911061	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr11:94911061C>T	uc001pfk.1	-	8	1291	c.1069G>A	c.(1069-1071)GAA>AAA	p.E357K	SESN3_uc010rug.1_Missense_Mutation_p.E218K	NM_144665	NP_653266	P58005	SESN3_HUMAN	sestrin 3	357					cell cycle arrest	nucleus					0		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)		BRCA - Breast invasive adenocarcinoma(274;0.234)		CCATGATTTTCCCAGGTATAG	0.313		NaN											0	0	0	0.000602214	0	5	15									
DSCAML1	57453	broad.mit.edu	37	11	117667803	117667803	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr11:117667803G>C	uc001prh.1	-	1	174	c.172C>G	c.(172-174)CTT>GTT	p.L58V	DSCAML1_uc001pri.1_Intron	NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	Error:Variant_position_missing_in_Q8TD84_after_alignment					axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		ATGCCATAAAGAGGCCCTATT	0.542		NaN											0	0	0	6.4e-05	0	3	50									
NCAPD2	9918	broad.mit.edu	37	12	6638150	6638150	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr12:6638150C>T	uc001qoo.2	+	27	3563	c.3517C>T	c.(3517-3519)CGC>TGC	p.R1173C	NCAPD2_uc010sfd.1_Missense_Mutation_p.R1128C	NM_014865	NP_055680	Q15021	CND1_HUMAN	non-SMC condensin I complex, subunit D2	1173					cell division|mitotic chromosome condensation	condensin core heterodimer|cytoplasm	histone binding			ovary(2)|lung(1)|breast(1)|kidney(1)	5						TATCATCAGCCGCCTGTCAGA	0.517		NaN											0	0	0	0.000566183	0	15	81									
A2ML1	144568	broad.mit.edu	37	12	9020633	9020633	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr12:9020633C>T	uc001quz.3	+	30	4011	c.3913C>T	c.(3913-3915)CAG>TAG	p.Q1305*	A2ML1_uc001qva.1_Nonsense_Mutation_p.Q885*|A2ML1_uc010sgm.1_Nonsense_Mutation_p.Q805*|A2ML1_uc001qvb.1_RNA	NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	1149						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3						GGCCTCAGGCCAGGGCTGTGT	0.507		NaN											0	0	0	0.000274275	0	8	73									
ITPR2	3709	broad.mit.edu	37	12	26818878	26818878	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr12:26818878G>A	uc001rhg.2	-	14	1933	c.1516C>T	c.(1516-1518)CAA>TAA	p.Q506*		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	506	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					ATCAATTTTTGACGCTCTCGG	0.348		NaN											0	0	0	0.000442599	0	9	67									
UHRF1BP1L	23074	broad.mit.edu	37	12	100452896	100452896	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr12:100452896T>A	uc001tgq.2	-	14	2388	c.2159A>T	c.(2158-2160)GAC>GTC	p.D720V	UHRF1BP1L_uc001tgp.2_Missense_Mutation_p.D370V	NM_015054	NP_055869	A0JNW5	UH1BL_HUMAN	UHRF1 (ICBP90) binding protein 1-like isoform a	720										ovary(2)	2						AGGGAATGAGTCTACAAAACT	0.398		NaN											0	0	0	8.12818e-05	0	7	65									
TBX5	6910	broad.mit.edu	37	12	114793599	114793599	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr12:114793599G>A	uc001tvo.2	-	9	1790	c.1295C>T	c.(1294-1296)TCG>TTG	p.S432L	TBX5_uc001tvp.2_Missense_Mutation_p.S432L|TBX5_uc001tvq.2_Missense_Mutation_p.S382L	NM_181486	NP_852259	Q99593	TBX5_HUMAN	T-box 5 isoform 1	432				MDRLPYQHFSAHFTSGPLVPRLAGMANHGSPQLGEGMFQHQ TS -> WTGYPTSTSPLTSPRGPWSLGWLAWQPWLPTAGRG NVPSTRPP (in Ref. 1; CAA70592).	cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(6)|pancreas(1)|skin(1)	8	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		CAGGGGCCCCGAGGTGAAGTG	0.647		NaN											0	0	0	3.59834e-05	0	5	31									
GLT1D1	144423	broad.mit.edu	37	12	129432001	129432001	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr12:129432001G>A	uc010tbh.1	+	11	802	c.793G>A	c.(793-795)GAG>AAG	p.E265K	GLT1D1_uc001uhx.1_Missense_Mutation_p.E180K|GLT1D1_uc001uhy.1_RNA	NM_144669	NP_653270	Q96MS3	GL1D1_HUMAN	glycosyltransferase 1 domain containing 1	260					biosynthetic process	extracellular region	transferase activity, transferring glycosyl groups				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.97e-06)|Epithelial(86;3.97e-05)|all cancers(50;0.00019)		TGCAATTTTGGAGGTAATTAT	0.458		NaN											0	0	0	0.000151284	0	10	65									
EP400	57634	broad.mit.edu	37	12	132446281	132446281	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr12:132446281T>C	uc001ujn.2	+	1	1152	c.1117T>C	c.(1117-1119)TAC>CAC	p.Y373H	EP400_uc001ujl.2_Missense_Mutation_p.Y373H|EP400_uc001ujm.2_Missense_Mutation_p.Y373H|EP400_uc001ujj.1_Missense_Mutation_p.Y373H|EP400_uc001ujk.2_Missense_Mutation_p.Y373H	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	373					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		GGACTATCATTACCAGGAGAT	0.473		NaN											0	0	0	0.000157383	0	8	66									
RASL11A	387496	broad.mit.edu	37	13	27845086	27845086	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr13:27845086G>C	uc001urd.1	+	1	623	c.5G>C	c.(4-6)CGG>CCG	p.R2P		NM_206827	NP_996563	Q6T310	RSLBA_HUMAN	RAS-like, family 11, member A	2					positive regulation of transcription from RNA polymerase I promoter|small GTPase mediated signal transduction|transcription, DNA-dependent	membrane|nucleolus	GTP binding|GTPase activity			breast(1)	1		Lung SC(185;0.0161)	Colorectal(13;0.00042)|READ - Rectum adenocarcinoma(15;0.105)	all cancers(112;0.0173)|GBM - Glioblastoma multiforme(144;0.0557)|OV - Ovarian serous cystadenocarcinoma(117;0.152)|Epithelial(112;0.164)		CGCTCCATGCGGCCGCTCAGC	0.706		NaN											0	0	0	6.4e-05	0	2	1									
CYSLTR2	57105	broad.mit.edu	37	13	49281341	49281341	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr13:49281341A>G	uc010acx.1	+	6	1071	c.388A>G	c.(388-390)ACC>GCC	p.T130A	CYSLTR2_uc010acy.1_Missense_Mutation_p.T130A|CYSLTR2_uc010acz.1_Missense_Mutation_p.T130A|CYSLTR2_uc010ada.1_Missense_Mutation_p.T130A|CYSLTR2_uc010adb.1_Missense_Mutation_p.T130A|CYSLTR2_uc010adc.1_Missense_Mutation_p.T130A|CYSLTR2_uc010add.1_Missense_Mutation_p.T130A|CYSLTR2_uc010acw.1_Missense_Mutation_p.T130A|CYSLTR2_uc001vck.2_Missense_Mutation_p.T130A	NM_020377	NP_065110	Q9NS75	CLTR2_HUMAN	cysteinyl leukotriene receptor 2	130	Helical; Name=3; (Potential).				immune response	integral to membrane|plasma membrane				lung(2)	2		all_cancers(8;1.66e-53)|all_epithelial(8;1.96e-19)|all_lung(13;9.94e-09)|all_hematologic(8;7.13e-07)|Lung NSC(96;1.72e-06)|Breast(56;1.53e-05)|Acute lymphoblastic leukemia(8;6.86e-05)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0416)|Lung SC(185;0.0787)		GBM - Glioblastoma multiforme(99;1.19e-09)	Nedocromil(DB00716)	TTATTTCCTGACCGTGCTGAG	0.468		NaN											0	0	0	6.4e-05	0	3	79									
KLHL1	57626	broad.mit.edu	37	13	70681399	70681399	+	Silent	SNP	G	G	A			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr13:70681399G>A	uc001vip.2	-	1	1227	c.433C>T	c.(433-435)CTG>TTG	p.L145L	KLHL1_uc010thm.1_Silent_p.L145L|ATXN8OS_uc010aej.1_RNA	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	145					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		AGCTCTTGCAGAACCAGCCCT	0.557		NaN											0	0	0	0.000586117	0	23	122									
F10	2159	broad.mit.edu	37	13	113795343	113795343	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr13:113795343G>C	uc001vsx.2	+	5	538	c.481G>C	c.(481-483)GGC>CGC	p.G161R	F10_uc010agq.1_RNA|F10_uc001vsy.2_Missense_Mutation_p.G161R|F10_uc001vsz.2_Missense_Mutation_p.G161R	NM_000504	NP_000495	P00742	FA10_HUMAN	coagulation factor X preproprotein	161	EGF-like 2.				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of cell migration|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen	calcium ion binding|phospholipid binding|protein binding|serine-type endopeptidase activity			pancreas(1)	1	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.113)|all_lung(25;0.0364)|all_epithelial(44;0.0373)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0805)|Epithelial(84;0.231)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Enoxaparin(DB01225)|Heparin(DB01109)|Menadione(DB00170)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGCTGACAACGGCAAGGCCTG	0.682		NaN											0	0	0	0.000602214	0	4	46									
TEP1	7011	broad.mit.edu	37	14	20876196	20876196	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr14:20876196G>C	uc001vxe.2	-	2	443	c.403C>G	c.(403-405)CAC>GAC	p.H135D	TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Missense_Mutation_p.H135D	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	135					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		TGCGTCATGTGAGATATCTGT	0.527		NaN											0	0	0	0.000219431	0	15	168									
THTPA	79178	broad.mit.edu	37	14	24028017	24028017	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr14:24028017G>A	uc001wkh.3	+	3	1031	c.661G>A	c.(661-663)GAG>AAG	p.E221K	THTPA_uc001wkb.3_RNA|THTPA_uc001wkg.3_Missense_Mutation_p.E221K|THTPA_uc010akr.2_RNA|THTPA_uc001wki.3_3'UTR|uc001wko.1_5'Flank	NM_001126339	NP_001119811	Q9BU02	THTPA_HUMAN	thiamine triphosphatase	221					dephosphorylation|generation of precursor metabolites and energy|thiamine metabolic process	cytosol|nucleolus|soluble fraction	thiamin-triphosphatase activity				0	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00643)	Thiamine(DB00152)	GAGGCCACAGGAGACTGAAGA	0.572		NaN									OREG0022604	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000602214	0	5	46									
G2E3	55632	broad.mit.edu	37	14	31077178	31077178	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr14:31077178C>G	uc001wqk.2	+	12	1557	c.1403C>G	c.(1402-1404)TCT>TGT	p.S468C	G2E3_uc010tpe.1_3'UTR|G2E3_uc010tpf.1_Missense_Mutation_p.S422C	NM_017769	NP_060239	Q7L622	G2E3_HUMAN	G2/M-phase specific E3 ubiquitin ligase	468	HECT.				apoptosis|multicellular organismal development|protein modification process	Golgi apparatus|nucleolus	acid-amino acid ligase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						GGTTTCTTTTCTAAAACCTTG	0.378		NaN											0	0	0	0.000157383	0	8	39									
C14orf181	400223	broad.mit.edu	37	14	69262546	69262546	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr14:69262546G>C	uc001xkj.1	-	1	645	c.466C>G	c.(466-468)CTC>GTC	p.L156V	ZFP36L1_uc001xkh.1_5'Flank|ZFP36L1_uc001xki.1_5'Flank	NM_207442	NP_997325			hypothetical protein LOC400223												0				all cancers(60;0.002)|BRCA - Breast invasive adenocarcinoma(234;0.00204)|OV - Ovarian serous cystadenocarcinoma(108;0.0399)		AGGGAGCCGAGAGGAGGGAGC	0.602		NaN											0	0	0	6.40141e-05	0	12	107									
PDIA3	2923	broad.mit.edu	37	15	44061801	44061801	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr15:44061801A>G	uc001zsu.2	+	10	1371	c.1223A>G	c.(1222-1224)CAC>CGC	p.H408R	PDIA3_uc010bdp.2_Missense_Mutation_p.H388R|PDIA3_uc010ued.1_Missense_Mutation_p.H182R	NM_005313	NP_005304	P30101	PDIA3_HUMAN	protein disulfide-isomerase A3 precursor	408	Thioredoxin 2.	Contributes to redox potential value (By similarity).			cell redox homeostasis|glycerol ether metabolic process|post-translational protein modification|protein folding|protein import into nucleus|protein N-linked glycosylation via asparagine|protein retention in ER lumen|signal transduction	endoplasmic reticulum lumen|melanosome	cysteine-type endopeptidase activity|electron carrier activity|phospholipase C activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			ovary(1)|skin(1)	2		all_cancers(109;2.61e-15)|all_epithelial(112;1.12e-12)|Lung NSC(122;2.17e-08)|all_lung(180;2.45e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.48e-07)		TGGTGTGGTCACTGTAAGAAC	0.393		NaN											0	0	0	0.00010058	0	11	73									
MYEF2	50804	broad.mit.edu	37	15	48443319	48443319	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr15:48443319C>T	uc001zwi.3	-	14	1480	c.1356G>A	c.(1354-1356)ATG>ATA	p.M452I	MYEF2_uc001zwg.3_5'Flank|MYEF2_uc001zwh.3_Intron|MYEF2_uc001zwj.3_Intron	NM_016132	NP_057216	Q9P2K5	MYEF2_HUMAN	myelin expression factor 2	452	Gly-rich.				transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding|nucleotide binding|RNA binding			lung(2)|ovary(1)	3		all_lung(180;0.00217)		all cancers(107;3.73e-10)|GBM - Glioblastoma multiforme(94;7.81e-07)		CTACTGGACCCATGTTAGAAG	0.323		NaN											0	0	0	0.000602214	0	5	26									
UNC13C	440279	broad.mit.edu	37	15	54586192	54586192	+	Silent	SNP	T	T	C			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr15:54586192T>C	uc002ack.2	+	9	3918	c.3918T>C	c.(3916-3918)GAT>GAC	p.D1306D	UNC13C_uc002acl.2_Silent_p.D136D	NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1306	C2 1.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		AGGAGTCAGATGATTTTCTGG	0.368		NaN											0	0	0	0.000175454	0	19	80									
HAGH	3029	broad.mit.edu	37	16	1859330	1859330	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr16:1859330C>A	uc002cna.2	-	9	1288	c.881G>T	c.(880-882)CGG>CTG	p.R294L	HAGH_uc002cmz.2_Missense_Mutation_p.R246L|HAGH_uc010uvp.1_3'UTR|HAGH_uc002cnb.1_3'UTR	NM_005326	NP_005317	Q16775	GLO2_HUMAN	hydroxyacylglutathione hydrolase isoform 1	294					glutathione biosynthetic process	cytoplasm|mitochondrial matrix|mitochondrial matrix	hydroxyacylglutathione hydrolase activity|zinc ion binding			ovary(1)	1		Hepatocellular(780;0.00335)			Glutathione(DB00143)	GCGCACGGCCCGCATGGTGGT	0.662		NaN											1	0	0.000442599	0.000442599	0.00505904	9	175									
TMC7	79905	broad.mit.edu	37	16	19058553	19058553	+	Silent	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr16:19058553C>T	uc002dfq.2	+	12	1852	c.1722C>T	c.(1720-1722)ATC>ATT	p.I574I	TMC7_uc002dfp.2_Silent_p.I574I|TMC7_uc010vap.1_Silent_p.I464I	NM_024847	NP_079123	Q7Z402	TMC7_HUMAN	transmembrane channel-like 7 isoform a	574	Helical; (Potential).					integral to membrane				skin(2)|ovary(1)	3						AATTCATTATCATCTTCTATG	0.368		NaN											0	0	0	0.000319135	0	39	314									
EEF2K	29904	broad.mit.edu	37	16	22269882	22269882	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr16:22269882C>T	uc002dki.2	+	10	1582	c.1097C>T	c.(1096-1098)TCT>TTT	p.S366F	EEF2K_uc002dkh.2_RNA	NM_013302	NP_037434	O00418	EF2K_HUMAN	elongation factor-2 kinase	366					insulin receptor signaling pathway|translational elongation	cytosol	ATP binding|calcium ion binding|calmodulin binding|elongation factor-2 kinase activity|translation factor activity, nucleic acid binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(48;0.0223)		AGGACCCTCTCTGGGAGCCGG	0.547		NaN											0	0	0	0.000279167	0	30	68									
ALDOA	226	broad.mit.edu	37	16	30080666	30080666	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr16:30080666G>A	uc002dvw.2	+	9	1708	c.580G>A	c.(580-582)GAT>AAT	p.D194N	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|ALDOA_uc002dvx.2_Missense_Mutation_p.D194N|ALDOA_uc002dvy.2_Missense_Mutation_p.D194N|ALDOA_uc002dvz.2_Missense_Mutation_p.D194N|ALDOA_uc002dwa.3_Missense_Mutation_p.D194N|ALDOA_uc002dwb.1_Missense_Mutation_p.D194N|ALDOA_uc002dwc.2_Missense_Mutation_p.D194N|ALDOA_uc010veg.1_Missense_Mutation_p.D248N|ALDOA_uc002dwd.2_Missense_Mutation_p.D198N	NM_184043	NP_908932	P04075	ALDOA_HUMAN	fructose-bisphosphate aldolase A	194					actin filament organization|ATP biosynthetic process|fructose 1,6-bisphosphate metabolic process|gluconeogenesis|glycolysis|muscle cell homeostasis|platelet activation|platelet degranulation|protein homotetramerization|regulation of cell shape|striated muscle contraction	actin cytoskeleton|cytosol|extracellular vesicular exosome|I band|platelet alpha granule lumen	actin binding|fructose binding|fructose-bisphosphate aldolase activity|identical protein binding|tubulin binding			lung(1)	1						GATCCTCCCTGATGGGGACCA	0.602		NaN									OREG0023729	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000219431	0	12	88									
NETO2	81831	broad.mit.edu	37	16	47162452	47162452	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr16:47162452C>T	uc002eer.1	-	4	650	c.265G>A	c.(265-267)GAT>AAT	p.D89N	NETO2_uc010vgf.1_5'UTR|NETO2_uc002ees.1_Missense_Mutation_p.D89N	NM_018092	NP_060562	Q8NC67	NETO2_HUMAN	neuropilin- and tolloid-like protein 2	89	Extracellular (Potential).|CUB 1.					integral to membrane	receptor activity				0		all_cancers(37;0.00114)|all_lung(18;0.00432)|Lung NSC(13;0.0384)|Breast(268;0.174)				TAATGTTCATCAAAGGTCAAC	0.358		NaN								HNSCC(25;0.065)			0	0	0	0.000566183	0	14	125									
FHOD1	29109	broad.mit.edu	37	16	67263612	67263612	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr16:67263612G>A	uc002esl.2	-	22	3534	c.3422C>T	c.(3421-3423)ACG>ATG	p.T1141M	LRRC29_uc002ese.2_5'Flank|LRRC29_uc002esf.2_5'Flank|LRRC29_uc002esg.2_5'Flank|LRRC29_uc010vjg.1_5'Flank|FHOD1_uc002esk.2_Missense_Mutation_p.T200M|FHOD1_uc010ced.2_Missense_Mutation_p.T948M	NM_013241	NP_037373	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	1141					actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(2)|ovary(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		ACTCTTCAACGTCCTTCTCAC	0.582		NaN											0	0	0	0.000958276	0	18	108									
MBTPS1	8720	broad.mit.edu	37	16	84096944	84096944	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr16:84096944G>C	uc002fhi.2	-	19	3040	c.2538C>G	c.(2536-2538)GAC>GAG	p.D846E	MBTPS1_uc002fhh.2_Missense_Mutation_p.D350E	NM_003791	NP_003782	Q14703	MBTP1_HUMAN	membrane-bound transcription factor site-1	846	Lumenal (Potential).				cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			ovary(2)	2						AGCAATTGGAGTCCCCATACA	0.478		NaN									OREG0023981	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	3.59834e-05	0	5	140									
BANP	54971	broad.mit.edu	37	16	88039762	88039762	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr16:88039762C>G	uc002fkr.2	+	6	743	c.519C>G	c.(517-519)CAC>CAG	p.H173Q	BANP_uc002fkp.2_Missense_Mutation_p.H143Q|BANP_uc002fkq.2_Missense_Mutation_p.H143Q|BANP_uc010vow.1_Missense_Mutation_p.H181Q|BANP_uc002fks.3_Missense_Mutation_p.H142Q|BANP_uc002fko.1_Missense_Mutation_p.H79Q|BANP_uc010vov.1_Missense_Mutation_p.H148Q	NM_079837	NP_524576	Q8N9N5	BANP_HUMAN	BTG3 associated nuclear protein isoform b	174	Interaction with CUX1 and HDAC1 (By similarity).				cell cycle|chromatin modification|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0				BRCA - Breast invasive adenocarcinoma(80;0.00551)		ACAGCCACCACGAGGACGGGG	0.627		NaN											0	0	0	0.00074312	0	14	123									
TP53	7157	broad.mit.edu	37	17	7577539	7577539	+	Missense_Mutation	SNP	G	G	A	rs121912651		TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr17:7577539G>A	uc002gim.2	-	7	936	c.742C>T	c.(742-744)CGG>TGG	p.R248W	TP53_uc002gig.1_Missense_Mutation_p.R248W|TP53_uc002gih.2_Missense_Mutation_p.R248W|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116W|TP53_uc010cng.1_Missense_Mutation_p.R116W|TP53_uc002gii.1_Missense_Mutation_p.R116W|TP53_uc010cnh.1_Missense_Mutation_p.R248W|TP53_uc010cni.1_Missense_Mutation_p.R248W|TP53_uc002gij.2_Missense_Mutation_p.R248W|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155W|TP53_uc002gio.2_Missense_Mutation_p.R116W	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(516)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGGGCCTCCGGTTCATGCCG	0.577	R248W(CAS1_CENTRAL_NERVOUS_SYSTEM)|R248W(COLO680N_OESOPHAGUS)|R248W(SW837_LARGE_INTESTINE)|R248W(KO52_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248W(RD_SOFT_TISSUE)|R248W(VCAP_PROSTATE)|R248W(JIMT1_BREAST)|R248W(GCT_SOFT_TISSUE)|R248W(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248W(786O_KIDNEY)|R248W(COLO320_LARGE_INTESTINE)|R248W(LXF289_LUNG)|R248W(LUDLU1_LUNG)|R248W(MIAPACA2_PANCREAS)|R248W(HCC2157_BREAST)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.000878237	0	24	79									
KDM6B	23135	broad.mit.edu	37	17	7749991	7749991	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr17:7749991C>T	uc002giw.1	+	8	1020	c.644C>T	c.(643-645)TCA>TTA	p.S215L	KDM6B_uc002gix.2_5'Flank	NM_001080424	NP_001073893	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	215	Pro-rich.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|pancreas(1)	2						GCAGCACTCTCAGGCCCCTCA	0.637		NaN											0	0	0	0.000308642	0	15	86									
MYH13	8735	broad.mit.edu	37	17	10248880	10248880	+	Silent	SNP	C	C	A			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr17:10248880C>A	uc002gmk.1	-	14	1407	c.1317G>T	c.(1315-1317)CTG>CTT	p.L439L	MYH13_uc010vvf.1_Silent_p.L114L	NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	439	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						TGACCATCCACAGGAACATCT	0.517		NaN											1	0	1.12685e-05	0.000274275	0.000130383	6	137									
C17orf48	56985	broad.mit.edu	37	17	10614321	10614321	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr17:10614321G>A	uc002gmt.2	+	4	964	c.889G>A	c.(889-891)GAA>AAA	p.E297K	C17orf48_uc002gmu.2_RNA|C17orf48_uc002gmv.2_RNA	NM_020233	NP_064618	Q3LIE5	ADPRM_HUMAN	ADP-ribose/CDP-alcohol pyrophosphatase	297							ADP-ribose diphosphatase activity|CDP-glycerol diphosphatase activity|metal ion binding				0						CGTCAACCTAGAAGGAGTTAT	0.463		NaN											0	0	0	0.000274275	0	8	51									
NCOR1	9611	broad.mit.edu	37	17	15989705	15989705	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr17:15989705C>G	uc002gpo.2	-	23	3308	c.3068G>C	c.(3067-3069)CGG>CCG	p.R1023P	NCOR1_uc002gpn.2_Missense_Mutation_p.R1039P|NCOR1_uc002gpp.1_Missense_Mutation_p.R930P|NCOR1_uc002gpq.1_Missense_Mutation_p.R115P	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	1023	Interaction with ETO.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		TGTCGGAAGCCGAACGCCTTC	0.458		NaN											0	0	0	8.12818e-05	0	7	37									
THRA	7067	broad.mit.edu	37	17	38244572	38244572	+	Silent	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr17:38244572C>T	uc002htw.2	+	8	1284	c.801C>T	c.(799-801)TAC>TAT	p.Y267Y	THRA_uc010cwp.1_Silent_p.Y267Y|THRA_uc002htv.2_Silent_p.Y267Y|THRA_uc002htx.2_Silent_p.Y267Y	NM_003250	NP_003241	P10827	THA_HUMAN	thyroid hormone receptor, alpha isoform 2	267	Ligand-binding.				negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of transcription initiation, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription from RNA polymerase II promoter	cytosol|nucleoplasm	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|TBP-class protein binding|thyroid hormone binding|thyroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding				0	Colorectal(19;0.000442)	Myeloproliferative disorder(1115;0.0255)			Levothyroxine(DB00451)|Liothyronine(DB00279)	CTGTCCGCTACGACCCTGAGA	0.637		NaN											0	0	0	0.000219431	0	12	87									
NBR1	4077	broad.mit.edu	37	17	41331419	41331419	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr17:41331419C>G	uc010czd.2	+	4	314	c.174C>G	c.(172-174)ATC>ATG	p.I58M	NBR1_uc010diz.2_Missense_Mutation_p.I58M|NBR1_uc010whu.1_Missense_Mutation_p.I58M|NBR1_uc010whv.1_Missense_Mutation_p.I58M|NBR1_uc010whw.1_Missense_Mutation_p.I37M	NM_031862	NP_114068	Q14596	NBR1_HUMAN	neighbor of BRCA1 gene 1	58	OPR.				macroautophagy|protein oligomerization	autophagic vacuole|cytoplasmic vesicle|cytosol|late endosome|lysosome|sarcomere	ubiquitin binding|zinc ion binding			skin(1)	1		Breast(137;0.00086)		BRCA - Breast invasive adenocarcinoma(366;0.0934)		AGGTATCCATCAACAGTCAAG	0.378		NaN											0	0	0	0.000602214	0	4	47									
TEX2	55852	broad.mit.edu	37	17	62254697	62254697	+	Silent	SNP	G	G	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr17:62254697G>T	uc002jec.2	-	6	2732	c.2559C>A	c.(2557-2559)CTC>CTA	p.L853L	TEX2_uc002jed.2_Silent_p.L860L|TEX2_uc002jee.2_Silent_p.L853L	NM_018469	NP_060939	Q8IWB9	TEX2_HUMAN	testis expressed sequence 2	853					signal transduction|sphingolipid metabolic process	integral to membrane				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		TTATTTTGCTGAGTTTCATTT	0.378		NaN											1	0	2.12542e-12	0.000147802	2.55321e-11	29	168									
SDK2	54549	broad.mit.edu	37	17	71394562	71394562	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr17:71394562C>T	uc010dfm.2	-	23	3100	c.3100G>A	c.(3100-3102)GTG>ATG	p.V1034M	SDK2_uc002jjt.3_Missense_Mutation_p.V193M|SDK2_uc010dfn.2_Missense_Mutation_p.V713M	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	1034	Fibronectin type-III 5.|Extracellular (Potential).				cell adhesion	integral to membrane				ovary(2)	2						TCCCCAACCACGCCTACCTGG	0.627		NaN											0	0	0	0.000442599	0	10	110									
RNF213	57674	broad.mit.edu	37	17	78319411	78319411	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr17:78319411A>G	uc002jyh.1	+	4	1718	c.1495A>G	c.(1495-1497)AAA>GAA	p.K499E		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			TGGCTGTGGGAAAACCAGGCT	0.502		NaN											0	0	0	0.000586117	0	22	155									
GALR1	2587	broad.mit.edu	37	18	74963033	74963033	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr18:74963033T>C	uc002lms.3	+	1	1026	c.529T>C	c.(529-531)TTC>CTC	p.F177L		NM_001480	NP_001471	P47211	GALR1_HUMAN	galanin receptor 1	177	Extracellular (Potential).				digestion|negative regulation of adenylate cyclase activity	integral to membrane|plasma membrane	galanin receptor activity			lung(1)	1		Prostate(75;0.0865)|Esophageal squamous(42;0.129)|Melanoma(33;0.211)		OV - Ovarian serous cystadenocarcinoma(15;1.03e-06)|BRCA - Breast invasive adenocarcinoma(31;0.104)		CCAGGGCCTCTTCCACCCGCG	0.677		NaN											0	0	0	0.000132079	0	18	54									
CD79A	973	broad.mit.edu	37	19	42383361	42383361	+	Splice_Site	SNP	T	T	G			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr19:42383361T>G	uc002orv.2	+	2	564	c.379_splice	c.e2+2	p.Q127_splice	CD79A_uc002oru.2_Intron	NM_001783	NP_001774	P11912	CD79A_HUMAN	CD79A antigen isoform 1 precursor						B cell differentiation|B cell proliferation|B cell receptor signaling pathway	B cell receptor complex|external side of plasma membrane|integral to membrane|membrane raft|multivesicular body	transmembrane receptor activity			ovary(2)|pancreas(1)	3						GCGTGCGCCGTGAGTGGCCCA	0.592		NaN	O|S		DLBCL								0	0	0	0.00010058	0	10	15									
PEG3	5178	broad.mit.edu	37	19	57328456	57328456	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr19:57328456A>G	uc002qnu.2	-	7	1705	c.1354T>C	c.(1354-1356)TAT>CAT	p.Y452H	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.Y423H|PEG3_uc002qnv.2_Missense_Mutation_p.Y452H|PEG3_uc002qnw.2_Missense_Mutation_p.Y328H|PEG3_uc002qnx.2_Missense_Mutation_p.Y326H|PEG3_uc010etr.2_Missense_Mutation_p.Y452H	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	452	C2H2-type 1.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TCACATACATATGGCATTGCC	0.488		NaN											0	0	0	0.000157383	0	6	87									
ALK	238	broad.mit.edu	37	2	29917721	29917721	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr2:29917721G>C	uc002rmy.2	-	3	1854	c.947C>G	c.(946-948)CCC>CGC	p.P316R		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	316	MAM 1.|Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	CTTACCTCTGGGCATCTCCTT	0.587		NaN	T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				0	0	0	0.000227799	0	25	80									
MOGS	7841	broad.mit.edu	37	2	74688895	74688895	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr2:74688895C>T	uc010ffj.2	-	4	2184	c.2021G>A	c.(2020-2022)CGG>CAG	p.R674Q	MOGS_uc010ffh.2_Missense_Mutation_p.R399Q|MOGS_uc010yrt.1_Missense_Mutation_p.R555Q|MOGS_uc010ffi.2_Missense_Mutation_p.R568Q	NM_006302	NP_006293	Q13724	MOGS_HUMAN	mannosyl-oligosaccharide glucosidase isoform 1	674	Lumenal (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|membrane fraction	mannosyl-oligosaccharide glucosidase activity				0						ACCCACCACCCGAACGAGCCC	0.582		NaN											0	0	0	0.000442599	0	9	99									
SEMA4C	54910	broad.mit.edu	37	2	97530101	97530101	+	Silent	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr2:97530101C>T	uc002sxh.3	-	10	1141	c.981G>A	c.(979-981)TCG>TCA	p.S327S	SEMA4C_uc002sxf.3_5'Flank|SEMA4C_uc002sxe.2_5'Flank|SEMA4C_uc002sxg.3_Silent_p.S380S	NM_017789	NP_060259	Q9C0C4	SEM4C_HUMAN	semaphorin 4C precursor	327	Extracellular (Potential).|Dominant negative effect on myogenic differentiation (By similarity).|Sema.				muscle cell differentiation|nervous system development|positive regulation of stress-activated MAPK cascade	cell junction|integral to membrane|postsynaptic density|postsynaptic membrane|synaptic vesicle membrane	receptor activity			skin(2)	2						CACAGATGGCCGACAGGTACA	0.582		NaN											0	0	0	0.00074312	0	16	162									
DDX18	8886	broad.mit.edu	37	2	118575041	118575041	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr2:118575041C>T	uc002tlh.1	+	2	206	c.107C>T	c.(106-108)TCG>TTG	p.S36L		NM_006773	NP_006764	Q9NVP1	DDX18_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18	36							ATP binding|ATP-dependent RNA helicase activity|RNA binding			breast(2)|ovary(1)|lung(1)	4						CTGACCCTATCGGAAACTCAA	0.358		NaN											0	0	0	0.000157383	0	7	87									
COL5A2	1290	broad.mit.edu	37	2	189904075	189904075	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr2:189904075C>T	uc002uqk.2	-	51	4123	c.3848G>A	c.(3847-3849)CGC>CAC	p.R1283H	COL5A2_uc010frx.2_Missense_Mutation_p.R859H	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	1283	Fibrillar collagen NC1.				axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			ATCGGGGCTGCGCATGGTTTC	0.522		NaN											0	0	0	0.000157383	0	7	53									
DIS3L2	129563	broad.mit.edu	37	2	233198629	233198629	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr2:233198629C>T	uc010fxz.2	+	17	2366	c.2090C>T	c.(2089-2091)ACA>ATA	p.T697I	DIS3L2_uc002vsm.3_RNA|DIS3L2_uc002vso.2_RNA|DIS3L2_uc002vsp.1_5'Flank	NM_152383	NP_689596	Q8IYB7	DI3L2_HUMAN	DIS3 mitotic control homolog (S.	697							exonuclease activity|ribonuclease activity|RNA binding			ovary(1)|breast(1)|central_nervous_system(1)	3		all_hematologic(139;0.00809)|Renal(207;0.0113)|Acute lymphoblastic leukemia(138;0.0195)|all_lung(227;0.0465)|Lung NSC(271;0.136)		Epithelial(121;1.6e-13)|BRCA - Breast invasive adenocarcinoma(100;0.00104)|LUSC - Lung squamous cell carcinoma(224;0.0109)|Lung(119;0.0149)		CCCCTGTACACACACTTCACC	0.662		NaN											0	0	0	0.00074312	0	18	92									
C20orf26	26074	broad.mit.edu	37	20	20279020	20279020	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr20:20279020G>A	uc002wru.2	+	25	3488	c.3412G>A	c.(3412-3414)GAT>AAT	p.D1138N	C20orf26_uc002wrw.2_RNA	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	1138										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		CCTGATCACAGATCTCTATAG	0.468		NaN											0	0	0	0.000442599	0	8	57									
ATP9A	10079	broad.mit.edu	37	20	50224073	50224073	+	Silent	SNP	G	G	A			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr20:50224073G>A	uc002xwg.1	-	26	2796	c.2796C>T	c.(2794-2796)ATC>ATT	p.I932I	ATP9A_uc010gih.1_Silent_p.I796I|ATP9A_uc002xwf.1_Silent_p.I104I	NM_006045	NP_006036	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	932	Helical; (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(4)	4						TACCTTGATAGATGCTAATCA	0.488		NaN											0	0	0	0.000151284	0	12	39									
PTK6	5753	broad.mit.edu	37	20	62168507	62168507	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr20:62168507C>T	uc002yfg.2	-	1	201	c.161G>A	c.(160-162)GGT>GAT	p.G54D	PTK6_uc011aay.1_Translation_Start_Site|PTK6_uc011aba.1_Missense_Mutation_p.G54D	NM_005975	NP_005966	Q13882	PTK6_HUMAN	PTK6 protein tyrosine kinase 6	54	SH3.					cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			stomach(1)|kidney(1)	2	all_cancers(38;2.51e-11)		Epithelial(9;1.5e-08)|all cancers(9;8.67e-08)|BRCA - Breast invasive adenocarcinoma(10;6.43e-06)			CACGGCCCCACCCGCCTCGTC	0.692		NaN											0	0	0	0.000308642	0	14	18									
MX1	4599	broad.mit.edu	37	21	42823170	42823170	+	Silent	SNP	G	G	A			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr21:42823170G>A	uc002yzh.2	+	17	2456	c.1509G>A	c.(1507-1509)AAG>AAA	p.K503K	MX1_uc002yzi.2_Silent_p.K503K|MX1_uc010goq.2_Silent_p.K503K	NM_001144925	NP_001138397	P20591	MX1_HUMAN	myxovirus resistance protein 1	503					induction of apoptosis|response to virus|type I interferon-mediated signaling pathway	cytosol	GTP binding|GTPase activity|protein binding			ovary(1)	1		Prostate(19;3.18e-07)|all_epithelial(19;0.0277)				GAACCGCCAAGGTAAAACCAA	0.308		NaN											0	0	0	0.000781405	0	119	244									
ITGB2	3689	broad.mit.edu	37	21	46306710	46306710	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr21:46306710T>C	uc002zgd.2	-	14	2232	c.2188A>G	c.(2188-2190)AGC>GGC	p.S730G	ITGB2_uc002zge.2_Missense_Mutation_p.S730G|ITGB2_uc002zgf.3_Missense_Mutation_p.S730G|ITGB2_uc011afl.1_Missense_Mutation_p.S652G|ITGB2_uc010gpw.2_Missense_Mutation_p.S673G|ITGB2_uc002zgg.2_Missense_Mutation_p.S730G	NM_001127491	NP_001120963	P05107	ITB2_HUMAN	integrin, beta 2 precursor	730	Cytoplasmic (Potential).				apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			ovary(4)|central_nervous_system(3)|breast(2)	9				Colorectal(79;0.0669)	Simvastatin(DB00641)	CGGAGGTCGCTCAGGTGGATC	0.627		NaN											0	0	0	6.4e-05	0	3	63									
EIF4ENIF1	56478	broad.mit.edu	37	22	31839041	31839041	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr22:31839041T>C	uc003akz.1	-	16	2277	c.2113A>G	c.(2113-2115)ATG>GTG	p.M705V	EIF4ENIF1_uc003akx.1_Missense_Mutation_p.M360V|EIF4ENIF1_uc003aky.1_Missense_Mutation_p.M385V|EIF4ENIF1_uc003ala.1_Missense_Mutation_p.M705V|EIF4ENIF1_uc003alb.1_Missense_Mutation_p.M531V|EIF4ENIF1_uc003akw.1_Missense_Mutation_p.M195V	NM_019843	NP_062817	Q9NRA8	4ET_HUMAN	eukaryotic translation initiation factor 4E	705						nucleus	protein binding|protein transporter activity			ovary(1)	1						CTCTCGTACATCTTACGAATC	0.458		NaN											0	0	0	0.000422831	0	16	49									
TRANK1	9881	broad.mit.edu	37	3	36872485	36872485	+	Silent	SNP	T	T	C			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr3:36872485T>C	uc003cgj.2	-	12	7109	c.6807A>G	c.(6805-6807)GTA>GTG	p.V2269V		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	2819					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						TGTGGATCCATACACTTTGCT	0.532		NaN											0	0	0	0.000781405	0	43	143									
KLHDC8B	200942	broad.mit.edu	37	3	49213182	49213182	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr3:49213182C>T	uc003cwh.2	+	6	1198	c.1013C>T	c.(1012-1014)GCC>GTC	p.A338V	KLHDC8B_uc003cwi.1_3'UTR	NM_173546	NP_775817	Q8IXV7	KLD8B_HUMAN	kelch domain containing 8B	338	Kelch 8.					cytoplasm					0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00217)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		GGGGGTGTGGCCCAGGGCCCC	0.662		NaN											0	0	0	0.000673444	0	10	58									
TRAT1	50852	broad.mit.edu	37	3	108565976	108565976	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr3:108565976G>A	uc003dxi.1	+	4	358	c.214G>A	c.(214-216)GAA>AAA	p.E72K	TRAT1_uc010hpx.1_Missense_Mutation_p.E35K	NM_016388	NP_057472	Q6PIZ9	TRAT1_HUMAN	T-cell receptor interacting molecule	72	Cytoplasmic (Potential).				cellular defense response|negative regulation of receptor recycling|negative regulation of transport|positive regulation of calcium-mediated signaling|positive regulation of T cell receptor signaling pathway|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	phosphatidylinositol-4,5-bisphosphate 3-kinase activity|transmembrane receptor protein tyrosine kinase adaptor activity			skin(1)	1						TATGATTTCAGGTAAGTTTTC	0.274		NaN											0	0	0	0.000602214	0	5	30									
ZDHHC23	254887	broad.mit.edu	37	3	113675335	113675335	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr3:113675335G>A	uc003eau.2	+	4	1321	c.1022G>A	c.(1021-1023)GGA>GAA	p.G341E	ZDHHC23_uc003eav.2_Missense_Mutation_p.G335E|ZDHHC23_uc003eaw.1_5'Flank	NM_173570	NP_775841	Q8IYP9	ZDH23_HUMAN	zinc finger, DHHC domain containing 23	341						integral to membrane	acyltransferase activity|zinc ion binding			ovary(2)	2						TATTGTCCTGGAGTTTATGCA	0.463		NaN											0	0	0	3.59834e-05	0	6	72									
COL6A6	131873	broad.mit.edu	37	3	130311550	130311550	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr3:130311550G>T	uc010htl.2	+	14	4386	c.4355G>T	c.(4354-4356)GGA>GTA	p.G1452V	COL6A6_uc003eni.3_5'UTR	NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	1452	Triple-helical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						GGAAACAGAGGACTAAATGGA	0.313		NaN											1	0	4.34311e-12	0.00058488	5.18424e-11	28	124									
PPP2R3A	5523	broad.mit.edu	37	3	135721343	135721343	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr3:135721343G>A	uc003eqv.1	+	2	1568	c.1003G>A	c.(1003-1005)GAA>AAA	p.E335K	PPP2R3A_uc011blz.1_Intron	NM_002718	NP_002709	Q06190	P2R3A_HUMAN	protein phosphatase 2, regulatory subunit B'',	335					protein dephosphorylation	protein phosphatase type 2A complex	calcium ion binding|protein binding|protein phosphatase type 2A regulator activity			ovary(3)|pancreas(1)|lung(1)|breast(1)|skin(1)	7						CCCTAAATATGAAGATGTTGT	0.413		NaN											0	0	0	0.000442599	0	7	65									
PIK3CB	5291	broad.mit.edu	37	3	138478132	138478132	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr3:138478132C>T	uc011bmq.1	-	1	54	c.54G>A	c.(52-54)TGG>TGA	p.W18*		NM_006219	NP_006210	P42338	PK3CB_HUMAN	catalytic phosphatidylinositol 3-kinase beta	18					activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						AATCCACCGCCCAGATGTCAA	0.463		NaN											0	0	0	0.000602214	0	5	46									
SLC33A1	9197	broad.mit.edu	37	3	155571496	155571496	+	Silent	SNP	G	G	A			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr3:155571496G>A	uc003fan.3	-	1	672	c.291C>T	c.(289-291)CTC>CTT	p.L97L	SLC33A1_uc003fao.1_Silent_p.L97L	NM_004733	NP_004724	O00400	ACATN_HUMAN	acetyl-coenzyme A transporter	97	Extracellular (Potential).				cell death|transmembrane transport	endoplasmic reticulum membrane|Golgi membrane|integral to plasma membrane|membrane fraction	acetyl-CoA transporter activity			ovary(2)|large_intestine(1)|pancreas(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TTTGCAAAATGAGTGGGATGC	0.483		NaN											0	0	0	0.000157383	0	8	74									
GFM1	85476	broad.mit.edu	37	3	158408110	158408110	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr3:158408110G>A	uc003fce.2	+	16	2175	c.2068G>A	c.(2068-2070)GAT>AAT	p.D690N	GFM1_uc003fcf.2_RNA|GFM1_uc003fcg.2_Missense_Mutation_p.D621N	NM_024996	NP_079272	Q96RP9	EFGM_HUMAN	G elongation factor, mitochondrial 1 precursor	690					mitochondrial translational elongation	mitochondrion	GTP binding|GTPase activity|translation elongation factor activity			ovary(3)|central_nervous_system(1)	4			Lung(72;0.00309)|LUSC - Lung squamous cell carcinoma(72;0.0043)			ACTGTATGCAGATGTAAGTAG	0.408		NaN											0	0	0	0.000442599	0	9	80									
ACTL6A	86	broad.mit.edu	37	3	179301231	179301231	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr3:179301231C>T	uc003fjw.2	+	12	1290	c.1117C>T	c.(1117-1119)CCT>TCT	p.P373S	ACTL6A_uc003fjx.2_Missense_Mutation_p.P331S|ACTL6A_uc003fjy.2_Missense_Mutation_p.P331S	NM_004301	NP_004292	O96019	ACL6A_HUMAN	actin-like 6A isoform 1	373					chromatin remodeling|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|nervous system development|regulation of growth|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	Ino80 complex|npBAF complex|NuA4 histone acetyltransferase complex|plasma membrane|SWI/SNF complex	ATP binding|chromatin binding			ovary(1)	1	all_cancers(143;3.94e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.98e-26)|GBM - Glioblastoma multiforme(14;0.0169)			TCAGAAAACTCCTCCAGTAAG	0.368		NaN											0	0	0	0.000442599	0	9	82									
KIAA1530	57654	broad.mit.edu	37	4	1374711	1374711	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr4:1374711G>A	uc003gde.3	+	12	2243	c.1796G>A	c.(1795-1797)CGG>CAG	p.R599Q	KIAA1530_uc010ibv.2_Missense_Mutation_p.R150Q	NM_020894	NP_065945	Q2YD98	K1530_HUMAN	hypothetical protein LOC57654	599											0			OV - Ovarian serous cystadenocarcinoma(23;0.0138)			GACGAAGGACGGCCGCTCGAC	0.677		NaN											0	0	0	0.00074312	0	13	54									
FAM53A	152877	broad.mit.edu	37	4	1643302	1643302	+	Silent	SNP	G	G	A	rs151156399		TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr4:1643302G>A	uc011bve.1	-	5	1113	c.915C>T	c.(913-915)CTC>CTT	p.L305L	FAM53A_uc010ibw.2_Nonsense_Mutation_p.Q357*	NM_001013622	NP_001013644	Q6NSI3	FA53A_HUMAN	dorsal neural-tube nuclear protein	305						nucleus					0		all_epithelial(65;0.206)|Breast(71;0.212)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)			CTTCGTAATTGAGGGAGCAAA	0.502		NaN											0	0	0	0.000781405	0	43	319									
TACC3	10460	broad.mit.edu	37	4	1730206	1730206	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr4:1730206G>C	uc003gdo.2	+	4	1185	c.1077G>C	c.(1075-1077)GAG>GAC	p.E359D	TACC3_uc010ibz.2_Missense_Mutation_p.E359D|TACC3_uc003gdp.2_Intron|TACC3_uc010ica.2_5'Flank	NM_006342	NP_006333	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing	359						centrosome				ovary(1)|central_nervous_system(1)	2		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			GACTGGGAGAGAGGTCCGGCC	0.597		NaN											0	0	0	3.59834e-05	0	5	73									
HAUS3	79441	broad.mit.edu	37	4	2242103	2242103	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr4:2242103G>A	uc003ges.1	-	2	801	c.571C>T	c.(571-573)CCA>TCA	p.P191S	POLN_uc011bvi.1_Intron|HAUS3_uc011bvj.1_Missense_Mutation_p.P191S|HAUS3_uc003get.1_Missense_Mutation_p.P191S	NM_024511	NP_078787	Q68CZ6	HAUS3_HUMAN	HAUS augmin-like complex, subunit 3	191					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle				large_intestine(2)|breast(2)	4						aataccagtggatttgtccct	0.035		NaN											0	0	0	0.000602214	0	5	27									
SH3BP2	6452	broad.mit.edu	37	4	2831314	2831314	+	Silent	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr4:2831314C>T	uc003gfi.3	+	8	801	c.681C>T	c.(679-681)ACC>ACT	p.T227T	SH3BP2_uc011bvp.1_Silent_p.T255T|SH3BP2_uc003gfj.3_Silent_p.T284T|SH3BP2_uc003gfk.3_Silent_p.T227T|SH3BP2_uc003gfl.3_Silent_p.T160T|SH3BP2_uc003gfm.3_Silent_p.T202T	NM_001122681	NP_001116153	P78314	3BP2_HUMAN	SH3-domain binding protein 2 isoform a	227					signal transduction		SH3 domain binding|SH3/SH2 adaptor activity			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.164)		ACTCCTTTACCTCCAAGGGCC	0.677		NaN							Cherubism				0	0	0	0.000151284	0	13	101									
C1QTNF7	114905	broad.mit.edu	37	4	15444248	15444248	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr4:15444248C>T	uc011bxb.1	+	3	922	c.695C>T	c.(694-696)TCG>TTG	p.S232L	C1QTNF7_uc003gno.2_Missense_Mutation_p.S239L|C1QTNF7_uc003gnp.2_Missense_Mutation_p.S232L	NM_001135171	NP_001128643	Q9BXJ2	C1QT7_HUMAN	C1q and tumor necrosis factor related protein 7	232	C1q.					collagen					0						GATGTGGCTTCGGGGTCCACA	0.502		NaN											0	0	0	0.000781405	0	60	96									
GRID2	2895	broad.mit.edu	37	4	94006340	94006340	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr4:94006340C>G	uc011cdt.1	+	3	697	c.439C>G	c.(439-441)CGC>GGC	p.R147G	GRID2_uc010ikx.2_Missense_Mutation_p.R147G|GRID2_uc011cdu.1_Intron|GRID2_uc011cdv.1_RNA	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	147	Extracellular (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	TCTCTCAGTTCGCCCACCTGT	0.478		NaN											0	0	0	0.000602214	0	5	27									
FBXW7	55294	broad.mit.edu	37	4	153244124	153244124	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr4:153244124G>C	uc003ims.2	-	12	2182	c.2033C>G	c.(2032-2034)TCA>TGA	p.S678*	FBXW7_uc011cii.1_Nonsense_Mutation_p.S678*|FBXW7_uc003imt.2_Nonsense_Mutation_p.S678*|FBXW7_uc011cih.1_Nonsense_Mutation_p.S502*|FBXW7_uc003imq.2_Nonsense_Mutation_p.S598*|FBXW7_uc003imr.2_Nonsense_Mutation_p.S560*	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	678					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding			haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				CTTTGTGTTTGAGGCTCTGAT	0.493		NaN	Mis|N|D|F		colorectal|endometrial|T-ALL								0	0	0	0.000781405	0	47	52									
GALNTL6	442117	broad.mit.edu	37	4	173269794	173269794	+	Silent	SNP	G	G	A			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr4:173269794G>A	uc003isv.2	+	5	1243	c.507G>A	c.(505-507)GGG>GGA	p.G169G		NM_001034845	NP_001030017	Q49A17	GLTL6_HUMAN	N-acetylgalactosaminyltransferase-like 6	169	Catalytic subdomain A.|Lumenal (Potential).					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|ovary(1)|skin(1)	4						GAACCCCAGGGAGTCTGATAG	0.403		NaN											0	0	0	0.000219431	0	14	29									
RASA1	5921	broad.mit.edu	37	5	86645051	86645051	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr5:86645051C>G	uc003kiw.2	+	8	1241	c.1123C>G	c.(1123-1125)CTT>GTT	p.L375V	RASA1_uc010jav.2_RNA|RASA1_uc003kix.2_Missense_Mutation_p.L198V|RASA1_uc011ctv.1_Missense_Mutation_p.L208V|RASA1_uc011ctw.1_Missense_Mutation_p.L209V|RASA1_uc010jaw.2_Missense_Mutation_p.L197V	NM_002890	NP_002881	P20936	RASA1_HUMAN	RAS p21 protein activator 1 isoform 1	375	SH2 2.				cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		CTGCAGTTTTCTTGTGAGGCC	0.333		NaN											0	0	0	0.000157383	0	8	32									
FSTL4	23105	broad.mit.edu	37	5	132736544	132736544	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr5:132736544G>A	uc003kyn.1	-	4	513	c.295C>T	c.(295-297)CCT>TCT	p.P99S		NM_015082	NP_055897	Q6MZW2	FSTL4_HUMAN	follistatin-like 4 precursor	99	Kazal-like.					extracellular region	calcium ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CCGCACACAGGCACGTAGCTG	0.602		NaN											0	0	0	0.000175454	0	19	46									
KDM3B	51780	broad.mit.edu	37	5	137727502	137727502	+	Silent	SNP	G	G	A			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr5:137727502G>A	uc003lcy.1	+	8	2381	c.2181G>A	c.(2179-2181)TCG>TCA	p.S727S	KDM3B_uc010jew.1_Silent_p.S383S|KDM3B_uc011cys.1_Intron	NM_016604	NP_057688	Q7LBC6	KDM3B_HUMAN	jumonji domain containing 1B	727	Ser-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(3)|upper_aerodigestive_tract(2)|lung(2)|kidney(2)|central_nervous_system(1)|skin(1)	11						GCTCCAGCTCGCCCACCAGCA	0.607		NaN											0	0	0	0.000442599	0	10	77									
PCDHGA3	56112	broad.mit.edu	37	5	140725479	140725479	+	Missense_Mutation	SNP	C	C	T	rs62378406		TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr5:140725479C>T	uc003ljm.1	+	1	1879	c.1879C>T	c.(1879-1881)CGC>TGC	p.R627C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_Missense_Mutation_p.R387C|PCDHGA3_uc011dap.1_Missense_Mutation_p.R627C	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	627	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGCGAGGTGCGCACGGCGCG	0.697		NaN											0	0	0	0.000229342	0	15	61									
COL23A1	91522	broad.mit.edu	37	5	177673290	177673290	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr5:177673290C>T	uc003mje.2	-	24	1736	c.1378G>A	c.(1378-1380)GGC>AGC	p.G460S	COL23A1_uc010jkt.2_Missense_Mutation_p.G342S	NM_173465	NP_775736	Q86Y22	CONA1_HUMAN	collagen, type XXIII, alpha 1	460	Extracellular (Potential).|Collagen-like 4.|Gly-rich.					collagen|integral to membrane|plasma membrane	protein binding			central_nervous_system(1)|skin(1)	2	all_cancers(89;0.00188)|Renal(175;0.000159)|Lung NSC(126;0.00814)|all_lung(126;0.0129)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	OV - Ovarian serous cystadenocarcinoma(192;0.153)|all cancers(165;0.172)		CCAATAAGGCCCGGTGGGCCA	0.557		NaN											0	0	0	0.00024832	0	3	6									
PECI	10455	broad.mit.edu	37	6	4117578	4117578	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr6:4117578C>T	uc003mwf.2	-	9	1030	c.993G>A	c.(991-993)TGG>TGA	p.W331*	C6orf201_uc003mwa.3_Intron|C6orf201_uc003mvz.3_Intron|C6orf201_uc011dhw.1_Intron|C6orf201_uc003mwb.3_Intron|PECI_uc003mwc.2_Nonsense_Mutation_p.W164*|PECI_uc003mwd.2_Nonsense_Mutation_p.W301*|PECI_uc003mwe.2_Nonsense_Mutation_p.W178*|PECI_uc010jnr.1_RNA	NM_206836	NP_996667	O75521	ECI2_HUMAN	peroxisomal D3,D2-enoyl-CoA isomerase isoform 2	331					fatty acid metabolic process	mitochondrion|peroxisomal matrix	dodecenoyl-CoA delta-isomerase activity|fatty-acyl-CoA binding				0	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				TCAGCCTGGTCCAGACTTCTT	0.383		NaN											0	0	0	0.000191422	0	34	54									
HIST1H2BF	8343	broad.mit.edu	37	6	26200019	26200019	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr6:26200019C>G	uc003ngx.2	+	1	233	c.233C>G	c.(232-234)GCT>GGT	p.A78G	HIST1H3D_uc003ngv.2_5'Flank|HIST1H2AD_uc003ngw.2_5'Flank	NM_003522	NP_003513	P62807	H2B1C_HUMAN	histone cluster 1, H2bf	78					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding				0		all_hematologic(11;0.196)				GCTGGCGAGGCTTCCCGCCTG	0.622		NaN											0	0	0	0.00074312	0	17	142									
BRPF3	27154	broad.mit.edu	37	6	36168333	36168333	+	Silent	SNP	G	G	A			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr6:36168333G>A	uc003olv.3	+	2	458	c.234G>A	c.(232-234)AAG>AAA	p.K78K	BRPF3_uc010jwb.2_Silent_p.K78K|BRPF3_uc011dtj.1_RNA|BRPF3_uc010jwc.2_RNA|BRPF3_uc011dtk.1_Silent_p.K78K	NM_015695	NP_056510	Q9ULD4	BRPF3_HUMAN	bromodomain and PHD finger containing, 3	78					histone H3 acetylation|platelet activation|platelet degranulation	cytosol|extracellular region|MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			ovary(1)|skin(1)	2						ATAGTAACAAGGAAAACAGTG	0.463		NaN											0	0	0	0.000673444	0	11	75									
C6orf142	90523	broad.mit.edu	37	6	54095691	54095691	+	Silent	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr6:54095691C>T	uc003pcg.3	+	11	1406	c.1293C>T	c.(1291-1293)CTC>CTT	p.L431L	C6orf142_uc003pch.3_Intron|C6orf142_uc011dxa.1_Silent_p.L966L	NM_138569	NP_612636	Q5VWP3	MLIP_HUMAN	hypothetical protein LOC90523	431						nuclear envelope|PML body	protein binding				0	Lung NSC(77;0.0317)					CTCACACCCTCCTCAGTCACA	0.463		NaN											0	0	0	6.40141e-05	0	12	60									
ZNF451	26036	broad.mit.edu	37	6	57013396	57013396	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr6:57013396C>T	uc003pdm.1	+	10	2737	c.2513C>T	c.(2512-2514)TCA>TTA	p.S838L	ZNF451_uc003pdl.2_Missense_Mutation_p.S838L|ZNF451_uc003pdn.1_Missense_Mutation_p.S838L|uc003pdq.1_Intron|ZNF451_uc003pdk.1_Missense_Mutation_p.S838L	NM_001031623	NP_001026794	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451 isoform 1	838					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			GCTAGTGCCTCACATACAGAG	0.373		NaN											0	0	0	0.000274275	0	8	13									
ASCC3	10973	broad.mit.edu	37	6	101049784	101049784	+	Missense_Mutation	SNP	T	T	G			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr6:101049784T>G	uc003pqk.2	-	34	5534	c.5205A>C	c.(5203-5205)TTA>TTC	p.L1735F		NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit	1735	Helicase C-terminal 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		TCTCTGCATTTAAGTGGTCAG	0.368		NaN											0	0	0	6.4e-05	0	3	53									
ROS1	6098	broad.mit.edu	37	6	117714423	117714423	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr6:117714423C>A	uc003pxp.1	-	11	1425	c.1226G>T	c.(1225-1227)AGT>ATT	p.S409I	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	409	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		TTGAGGTGCACTAATAGAGGG	0.348		NaN	T	GOPC|ROS1	glioblastoma|NSCLC								1	0	7.93312e-07	0.000219431	9.29308e-06	13	239									
STX11	8676	broad.mit.edu	37	6	144508445	144508445	+	Silent	SNP	C	C	G	rs145774130	byFrequency	TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr6:144508445C>G	uc003qks.3	+	2	873	c.681C>G	c.(679-681)CTC>CTG	p.L227L		NM_003764	NP_003755	O75558	STX11_HUMAN	syntaxin 11	227	t-SNARE coiled-coil homology.				cellular membrane fusion|intracellular protein transport|vesicle-mediated transport	Golgi apparatus|membrane	SNAP receptor activity			ovary(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(155;2.17e-06)|GBM - Glioblastoma multiforme(68;0.0492)		TACACGAGCTCTTCTTGCAGA	0.652		NaN							Familial_Hemophagocytic_Lymphohistiocytosis				0	0	0	8.12818e-05	0	7	30									
FIGNL1	63979	broad.mit.edu	37	7	50513419	50513419	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr7:50513419C>T	uc003tpc.2	-	4	1944	c.1567G>A	c.(1567-1569)GAA>AAA	p.E523K	FIGNL1_uc003tpb.2_Missense_Mutation_p.E412K|FIGNL1_uc003tpd.2_Missense_Mutation_p.E523K|FIGNL1_uc003tpe.2_Missense_Mutation_p.E523K|FIGNL1_uc010kyy.2_Missense_Mutation_p.E523K	NM_001042762	NP_001036227	Q6PIW4	FIGL1_HUMAN	fidgetin-like 1	523					ATP metabolic process|negative regulation of apoptosis|osteoblast differentiation|osteoblast proliferation|regulation of cell cycle	cytoplasm|nucleus	ATP binding|magnesium ion binding|nucleoside-triphosphatase activity			ovary(3)	3	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;3.73e-08)|all_hematologic(4;7.51e-06)				ACTAAAAATTCTGTTTTTATC	0.413		NaN											0	0	0	0.000878237	0	29	111									
TBL2	26608	broad.mit.edu	37	7	72988323	72988323	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr7:72988323T>C	uc003tyh.2	-	3	525	c.391A>G	c.(391-393)AGA>GGA	p.R131G	TBL2_uc011kex.1_Missense_Mutation_p.R95G|TBL2_uc010lbg.2_Missense_Mutation_p.R36G|TBL2_uc003tyi.2_5'UTR|TBL2_uc011key.1_Missense_Mutation_p.R2G|TBL2_uc010lbh.2_Missense_Mutation_p.R36G	NM_012453	NP_036585	Q9Y4P3	TBL2_HUMAN	transducin (beta)-like 2	131											0		Lung NSC(55;0.0659)|all_lung(88;0.152)				ACGTTGGCTCTCATGCTGCGG	0.602		NaN											0	0	0	0.000157383	0	8	104									
SLC25A40	55972	broad.mit.edu	37	7	87473129	87473129	+	Silent	SNP	T	T	C			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr7:87473129T>C	uc003uje.2	-	9	1032	c.681A>G	c.(679-681)AAA>AAG	p.K227K		NM_018843	NP_061331	Q8TBP6	S2540_HUMAN	mitochondrial carrier family protein	227					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			haematopoietic_and_lymphoid_tissue(1)	1	Esophageal squamous(14;0.00202)					ATAAACCAGATTTCTCACATA	0.294		NaN											0	0	0	0.000151284	0	12	20									
PON2	5445	broad.mit.edu	37	7	95041045	95041045	+	Silent	SNP	A	A	G			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr7:95041045A>G	uc003unv.2	-	5	535	c.414T>C	c.(412-414)AAT>AAC	p.N138N	PON2_uc003unu.2_Silent_p.N126N|PON2_uc010lfk.2_RNA|PON2_uc003unw.2_Silent_p.N51N	NM_000305	NP_000296	Q15165	PON2_HUMAN	paraoxonase 2 isoform 1	138					aromatic compound catabolic process	extracellular region|plasma membrane	arylesterase activity|identical protein binding|metal ion binding				0	all_cancers(62;9.35e-11)|all_epithelial(64;3.37e-09)		STAD - Stomach adenocarcinoma(171;0.0151)			TTTCCACTGTATTCTTGAATT	0.348		NaN											0	0	0	3.59834e-05	0	6	32									
SMURF1	57154	broad.mit.edu	37	7	98639810	98639810	+	Silent	SNP	G	G	A			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr7:98639810G>A	uc003upu.1	-	13	1700	c.1380C>T	c.(1378-1380)TAC>TAT	p.Y460Y	SMURF1_uc003upv.1_Silent_p.Y434Y|SMURF1_uc003upt.2_Silent_p.Y434Y	NM_020429	NP_065162	Q9HCE7	SMUF1_HUMAN	Smad ubiquitination regulatory factor 1 isoform	460	HECT.				BMP signaling pathway|cell differentiation|ectoderm development|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein export from nucleus|protein localization at cell surface|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|plasma membrane	activin binding|I-SMAD binding|R-SMAD binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|lung(1)	4	all_cancers(62;1.05e-08)|all_epithelial(64;4.34e-09)|Lung NSC(181;0.00902)|all_lung(186;0.0145)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)|Lung(104;0.224)			GGAAGAGCCCGTAATAAGGAT	0.388		NaN											0	0	0	0.000219431	0	11	120									
RELN	5649	broad.mit.edu	37	7	103214705	103214705	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr7:103214705C>T	uc003vca.2	-	30	4505	c.4345G>A	c.(4345-4347)GAG>AAG	p.E1449K	RELN_uc010liz.2_Missense_Mutation_p.E1449K	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1449					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TCGAACATCTCATTGTGATTG	0.458		NaN											0	0	0	8.12818e-05	0	6	58									
RELN	5649	broad.mit.edu	37	7	103275933	103275933	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr7:103275933C>G	uc003vca.2	-	19	2564	c.2404G>C	c.(2404-2406)GAT>CAT	p.D802H	RELN_uc010liz.2_Missense_Mutation_p.D802H	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	802	BNR 2.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		ATCCCATTATCATAAGAATAA	0.438		NaN											0	0	0	0.00024832	0	4	69									
CPA1	1357	broad.mit.edu	37	7	130022031	130022031	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr7:130022031G>A	uc003vpx.2	+	4	536	c.464G>A	c.(463-465)CGT>CAT	p.R155H	CPA1_uc011kpf.1_Missense_Mutation_p.R67H|CPA1_uc003vpw.2_Intron	NM_001868	NP_001859	P15085	CBPA1_HUMAN	carboxypeptidase A1 precursor	155					proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					TATGAAGGGCGTCCCATTTAC	0.552		NaN											0	0	0	0.000442599	0	9	100									
SLC37A3	84255	broad.mit.edu	37	7	140058547	140058547	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr7:140058547G>C	uc003vvo.2	-	6	580	c.414C>G	c.(412-414)TTC>TTG	p.F138L	SLC37A3_uc003vvp.2_Missense_Mutation_p.F138L|SLC37A3_uc010lnh.2_Missense_Mutation_p.F138L|SLC37A3_uc011kqz.1_Intron|SLC37A3_uc011kra.1_Missense_Mutation_p.F138L|SLC37A3_uc011krb.1_Missense_Mutation_p.F110L	NM_207113	NP_996996	Q8NCC5	SPX3_HUMAN	solute carrier family 37 (glycerol-3-phosphate	138					carbohydrate transport|transmembrane transport	integral to membrane				ovary(3)	3	Melanoma(164;0.0142)					ATTTGTTGTAGAAACGCAGCC	0.507		NaN											0	0	0	0.000586117	0	23	228									
KRBA1	84626	broad.mit.edu	37	7	149422508	149422508	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr7:149422508C>T	uc003wfz.2	+	10	1628	c.1229C>T	c.(1228-1230)TCC>TTC	p.S410F	KRBA1_uc010lpj.2_RNA|KRBA1_uc003wga.2_RNA|KRBA1_uc003wgb.2_Missense_Mutation_p.S78F	NM_032534	NP_115923	A5PL33	KRBA1_HUMAN	KRAB A domain containing 1	410										ovary(1)|central_nervous_system(1)	2	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			ACTTCTTGTTCCCAGAACCCC	0.602		NaN											0	0	0	8.12818e-05	0	6	26									
XKR6	286046	broad.mit.edu	37	8	10755762	10755762	+	Silent	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr8:10755762C>T	uc003wtk.1	-	3	1653	c.1626G>A	c.(1624-1626)ACG>ACA	p.T542T		NM_173683	NP_775954	Q5GH73	XKR6_HUMAN	XK, Kell blood group complex subunit-related	542						integral to membrane				ovary(1)|skin(1)	2				Lung(29;0.0407)|COAD - Colon adenocarcinoma(149;0.0555)		CTCTGGTGGGCGTAACCTGGG	0.637		NaN											0	0	0	0.000274275	0	8	38									
DLC1	10395	broad.mit.edu	37	8	12947882	12947882	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr8:12947882G>A	uc003wwm.2	-	15	4397	c.3953C>T	c.(3952-3954)TCA>TTA	p.S1318L	DLC1_uc003wwk.1_Missense_Mutation_p.S881L|DLC1_uc003wwl.1_Missense_Mutation_p.S915L|DLC1_uc011kxx.1_Missense_Mutation_p.S807L	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	1318	START.				actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						GTAGTCAGCTGAGTCATCATT	0.512		NaN											0	0	0	0.000673444	0	11	71									
RIMS2	9699	broad.mit.edu	37	8	105160951	105160951	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr8:105160951C>T	uc003yls.2	+	23	3504	c.3263C>T	c.(3262-3264)TCT>TTT	p.S1088F	RIMS2_uc003ylp.2_Intron|RIMS2_uc003ylw.2_Missense_Mutation_p.S1077F|RIMS2_uc003ylq.2_Intron|RIMS2_uc003ylr.2_Intron	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	516					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GGCAGCCAGTCTGACACTGCA	0.517		NaN								HNSCC(12;0.0054)			0	0	0	0.00024832	0	4	16									
SYBU	55638	broad.mit.edu	37	8	110592172	110592172	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr8:110592172G>T	uc003ynj.3	-	5	753	c.590C>A	c.(589-591)TCA>TAA	p.S197*	SYBU_uc003yni.3_Nonsense_Mutation_p.S194*|SYBU_uc003ynk.3_Nonsense_Mutation_p.S78*|SYBU_uc010mco.2_Nonsense_Mutation_p.S196*|SYBU_uc003ynl.3_Nonsense_Mutation_p.S196*|SYBU_uc010mcp.2_Nonsense_Mutation_p.S197*|SYBU_uc010mcq.2_Nonsense_Mutation_p.S197*|SYBU_uc003yno.3_Nonsense_Mutation_p.S78*|SYBU_uc010mcr.2_Nonsense_Mutation_p.S197*|SYBU_uc003ynm.3_Nonsense_Mutation_p.S196*|SYBU_uc003ynn.3_Nonsense_Mutation_p.S196*|SYBU_uc010mcs.2_Nonsense_Mutation_p.S78*|SYBU_uc010mct.2_Nonsense_Mutation_p.S197*|SYBU_uc010mcu.2_Nonsense_Mutation_p.S196*|SYBU_uc003ynp.3_Nonsense_Mutation_p.S129*|SYBU_uc010mcv.2_Nonsense_Mutation_p.S197*|SYBU_uc003ynh.3_5'UTR|SYBU_uc011lhw.1_Nonsense_Mutation_p.S67*	NM_001099754	NP_001093224	Q9NX95	SYBU_HUMAN	Golgi-localized syntaphilin-related protein	197	Sufficient for interaction with KIF5B.|Ser-rich.					cytoplasmic membrane-bounded vesicle|cytoskeleton|Golgi membrane|integral to membrane				ovary(1)	1						CCGCGGGGATGATGGGCTGCT	0.517		NaN											1	0	6.44725e-10	0.000295444	7.6475e-09	18	131									
ENPP2	5168	broad.mit.edu	37	8	120577110	120577110	+	Silent	SNP	G	G	A			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr8:120577110G>A	uc003yot.1	-	23	2303	c.2217C>T	c.(2215-2217)TTC>TTT	p.F739F	ENPP2_uc011lic.1_Silent_p.F277F|ENPP2_uc003yor.1_Silent_p.F374F|ENPP2_uc003yos.1_Silent_p.F791F|ENPP2_uc010mdd.1_Silent_p.F764F	NM_001040092	NP_001035181	Q13822	ENPP2_HUMAN	autotaxin isoform 2 preproprotein	739					cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)|kidney(1)	7	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			AGTCATAGTCGAAGATTGGTC	0.378		NaN											0	0	0	3.59834e-05	0	6	41									
ATAD2	29028	broad.mit.edu	37	8	124382178	124382178	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr8:124382178C>G	uc003yqh.3	-	7	922	c.814G>C	c.(814-816)GAT>CAT	p.D272H	ATAD2_uc011lii.1_Missense_Mutation_p.D63H|ATAD2_uc003yqi.3_RNA|ATAD2_uc003yqj.2_Missense_Mutation_p.D272H	NM_014109	NP_054828	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	272	Asp-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			tcatcatcatcatcatcgtca	0.164		NaN											0	0	0	0.000602214	0	5	23									
CPSF1	29894	broad.mit.edu	37	8	145622615	145622615	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr8:145622615G>C	uc003zcj.2	-	23	2474	c.2399C>G	c.(2398-2400)CCC>CGC	p.P800R		NM_013291	NP_037423	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1,	800					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			skin(1)	1	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			CCGCCAGTCGGGAAGCTGGTA	0.647		NaN											0	0	0	6.4e-05	0	2	3									
TOR2A	27433	broad.mit.edu	37	9	130496823	130496823	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr9:130496823G>A	uc004brs.3	-	2	227	c.172C>T	c.(172-174)CAG>TAG	p.Q58*	TOR2A_uc004brt.3_Nonsense_Mutation_p.Q58*|TOR2A_uc004brw.3_Nonsense_Mutation_p.Q58*|TOR2A_uc011maj.1_Intron|TOR2A_uc004bru.3_Intron|TOR2A_uc004brv.3_Intron|TOR2A_uc004brx.1_5'UTR	NM_001085347	NP_001078816	Q5JU69	TOR2A_HUMAN	torsin family 2, member A isoform a	58					chaperone mediated protein folding requiring cofactor	endoplasmic reticulum|extracellular region	ATP binding|nucleoside-triphosphatase activity				0						GCCAGGTGCTGAGCCAGGTCA	0.632		NaN									OREG0019509	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000308642	0	14	26									
ASS1	445	broad.mit.edu	37	9	133364826	133364826	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr9:133364826G>C	uc004bzm.2	+	13	1301	c.945G>C	c.(943-945)TTG>TTC	p.L315F	ASS1_uc004bzn.2_Missense_Mutation_p.L315F|ASS1_uc010mza.2_Missense_Mutation_p.L391F|ASS1_uc004bzo.2_Missense_Mutation_p.L296F|ASS1_uc010mzb.2_Missense_Mutation_p.L353F|ASS1_uc004bzp.2_Missense_Mutation_p.L315F|ASS1_uc010mzc.2_Missense_Mutation_p.L315F	NM_000050	NP_000041	P00966	ASSY_HUMAN	argininosuccinate synthetase 1	315					arginine biosynthetic process|urea cycle	cytosol	argininosuccinate synthase activity|ATP binding|protein binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(145;0.000514)	Adenosine triphosphate(DB00171)|L-Arginine(DB00125)|L-Aspartic Acid(DB00128)|L-Citrulline(DB00155)	GCCTGGGCTTGAAATTTGCTG	0.542		NaN											0	0	0	0.000375601	0	21	221									
FRMPD4	9758	broad.mit.edu	37	X	12736510	12736510	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chrX:12736510C>A	uc004cuz.1	+	16	4071	c.3565C>A	c.(3565-3567)CGC>AGC	p.R1189S	FRMPD4_uc011mij.1_Missense_Mutation_p.R1181S	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	1189					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						GAGTGTGGCCCGCCTTTGTGA	0.552		NaN											1	0	6.36457e-07	0.000586117	7.50224e-06	24	131									
FAM47C	442444	broad.mit.edu	37	X	37027156	37027156	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chrX:37027156C>G	uc004ddl.1	+	1	687	c.673C>G	c.(673-675)CAG>GAG	p.Q225E		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	225										ovary(3)	3						TCTCCGCCCACAGCCTCCCAA	0.647		NaN											0	0	0	0.000602214	0	5	79									
KDM6A	7403	broad.mit.edu	37	X	44949018	44949018	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chrX:44949018G>A	uc004dge.3	+	25	3954	c.3579G>A	c.(3577-3579)TGG>TGA	p.W1193*	KDM6A_uc011mkz.1_Nonsense_Mutation_p.W1245*|KDM6A_uc011mla.1_Nonsense_Mutation_p.W1148*|KDM6A_uc011mlb.1_Nonsense_Mutation_p.W1200*|KDM6A_uc011mlc.1_Nonsense_Mutation_p.W897*|KDM6A_uc011mld.1_Nonsense_Mutation_p.W832*	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	1193	JmjC.				histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TGGGTTCTTGGTGGCCCAATC	0.353		NaN	D|N|F|S		renal|oesophageal SCC|MM								0	0	0	0.000157383	0	6	16									
IGSF1	3547	broad.mit.edu	37	X	130411013	130411013	+	Silent	SNP	G	G	T			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chrX:130411013G>T	uc004ewd.2	-	14	2746	c.2508C>A	c.(2506-2508)ATC>ATA	p.I836I	IGSF1_uc004ewe.3_Silent_p.I830I|IGSF1_uc004ewf.2_Silent_p.I816I	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	836	Extracellular (Potential).|Ig-like C2-type 8.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						CCACCGAAATGATTAGAAAGT	0.498		NaN											1	0	8.28887e-21	0.000781405	1.0021e-19	52	446									
FAM58A	92002	broad.mit.edu	37	X	152858023	152858023	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chrX:152858023G>C	uc010nug.2	-	3	515	c.412C>G	c.(412-414)CTG>GTG	p.L138V				Q8N1B3	FA58A_HUMAN	RecName: Full=Cyclin-related protein FAM58B;	200					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent		protein kinase binding				0	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TAGACCTGCAGGGCCAGGTAG	0.692		NaN											0	0	0	8.12818e-05	0	7	31									
EMD	2010	broad.mit.edu	37	X	153609241	153609241	+	Splice_Site	SNP	G	G	A			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chrX:153609241G>A	uc004fkl.2	+	6	698	c.450_splice	c.e6-1	p.R150_splice		NM_000117	NP_000108	P50402	EMD_HUMAN	emerin						cellular response to growth factor stimulus|muscle contraction|muscle organ development|negative regulation of catenin import into nucleus|negative regulation of fibroblast proliferation|positive regulation of protein export from nucleus|regulation of canonical Wnt receptor signaling pathway	endoplasmic reticulum|integral to membrane|microtubule|nuclear inner membrane|nuclear outer membrane	actin binding|beta-tubulin binding				0	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TTTTGCCTCAGGGAACGCCCC	0.622		NaN											0	0	0	0.000219431	0	13	86									
SMARCE1	6605	broad.mit.edu	37	17	38792242	38792247	+	In_Frame_Del	DEL	TGTCTC	TGTCTC	-			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr17:38792242_38792247delTGTCTC	uc002hux.2	-	7	601_606	c.477_482delGAGACA	c.(475-483)CAGAGACAA>CAA	p.159_161QRQ>Q	SMARCE1_uc010wff.1_In_Frame_Del_p.124_126QRQ>Q|SMARCE1_uc010wfg.1_In_Frame_Del_p.89_91QRQ>Q|SMARCE1_uc002huy.2_In_Frame_Del_p.124_126QRQ>Q|SMARCE1_uc010wfh.1_In_Frame_Del_p.89_91QRQ>Q|SMARCE1_uc010wfi.1_In_Frame_Del_p.141_143QRQ>Q|SMARCE1_uc002huz.1_In_Frame_Del_p.124_126QRQ>Q|SMARCE1_uc010wfj.1_In_Frame_Del_p.141_143QRQ>Q	NM_003079	NP_003070	Q969G3	SMCE1_HUMAN	SWI/SNF-related matrix-associated	159_161					chromatin modification|negative regulation of transcription, DNA-dependent|nervous system development|nucleosome disassembly|regulation of transcription from RNA polymerase II promoter	nBAF complex|npBAF complex|nuclear chromosome|SWI/SNF complex|transcriptional repressor complex	chromatin binding|DNA binding|N-acetyltransferase activity|protein binding|protein N-terminus binding|transcription coactivator activity				0		Breast(137;0.000812)				CATGCGAGATTGTCTCTGTCGACTTT	0.422		NaN											NaN	NaN	NaN	NaN	NaN	16	99	---	---							
ZNF180	7733	broad.mit.edu	37	19	44982133	44982134	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr19:44982133_44982134delCT	uc002ozf.3	-	5	846_847	c.564_565delAG	c.(562-567)AGAGTCfs	p.R188fs	ZNF180_uc002ozh.3_5'UTR|ZNF180_uc002ozi.3_Frame_Shift_Del_p.R161fs|ZNF180_uc002ozg.3_Frame_Shift_Del_p.R187fs|ZNF180_uc010ejm.2_Frame_Shift_Del_p.R163fs	NM_013256	NP_037388	Q9UJW8	ZN180_HUMAN	zinc finger protein 180	188_189					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Prostate(69;0.0435)				CTTTTGCAGACTCTCTCATGAA	0.391		NaN											NaN	NaN	NaN	NaN	NaN	7	83	---	---